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Sample records for adverse prognosis factor

  1. Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines

    International Nuclear Information System (INIS)

    Glioblastoma multiforme (GBM) is the most aggressive and frequent brain tumor, albeit without cure. Although patient survival is limited to one year on average, significant variability in outcome is observed. The assessment of biomarkers is needed to gain better knowledge of this type of tumor, help prognosis, design and evaluate therapies. The neurodevelopmental polysialic acid neural cell adhesion molecule (PSA-NCAM) protein is overexpressed in various cancers. Here, we studied its expression in GBM and evaluated its prognosis value for overall survival (OS) and disease free survival (DFS). We set up a specific and sensitive enzyme linked immunosorbent assay (ELISA) test for PSA-NCAM quantification, which correlated well with PSA-NCAM semi quantitative analysis by immunohistochemistry, and thus provides an accurate quantitative measurement of PSA-NCAM content for the 56 GBM biopsies analyzed. For statistics, the Spearman correlation coefficient was used to evaluate the consistency between the immunohistochemistry and ELISA data. Patients' survival was estimated by using the Kaplan-Meier method, and curves were compared using the log-rank test. On multivariate analysis, the effect of potential risk factors on the DFS and OS were evaluated using the cox regression proportional hazard models. The threshold for statistical significance was p = 0.05. We showed that PSA-NCAM was expressed by approximately two thirds of the GBM at variable levels. On univariate analysis, PSA-NCAM content was an adverse prognosis factor for both OS (p = 0.04) and DFS (p = 0.0017). On multivariate analysis, PSA-NCAM expression was an independent negative predictor of OS (p = 0.046) and DFS (p = 0.007). Furthermore, in glioma cell lines, PSA-NCAM level expression was correlated to the one of olig2, a transcription factor required for gliomagenesis. PSA-NCAM represents a valuable biomarker for the prognosis of GBM patients

  2. Co-occurrence of diabetes and hopelessness predicts adverse prognosis following percutaneous coronary intervention

    DEFF Research Database (Denmark)

    Pedersen, Susanne S.; Denollet, Johan; Erdman, Ruud A M;

    2009-01-01

    We examined the impact of co-occurring diabetes and hopelessness on 3-year prognosis in percutaneous coronary intervention patients. Consecutive patients (n = 534) treated with the paclitaxel-eluting stent completed a set of questionnaires at baseline and were followed up for 3-year adverse...

  3. Factors influencing the prognosis in bladder cancer

    International Nuclear Information System (INIS)

    In the categories T1, T2 and T3NxM0 bladder cancer, with a diameter not exceeding 5 cm, the treatment in the Rotterdam Radio-Therapy Institute consists of interstitial irradiation with needles containing radioactive material. The results of treatment and the role of additional external irradiation are discussed. Category T3NxM0 tumors with a diameter exceeding 5 cm are treated by external irradiation followed by cystectomy; the results are presented here. Factors influencing prognosis appeared to be the degree of differentiation, number of transurethral resections (TURs) prior to definitive treatment, intravenous pyelography (IVP), vascular invasion, T category after preoperative irradiation, and postsurgical histopathologically-assessed T category (pT)

  4. Prognosis related clinical and molecular factors in malignant pleural mesothelioma

    Institute of Scientific and Technical Information of China (English)

    王玉艳

    2013-01-01

    Objective To identify potential prognosis related clinical and molecular factors in malignant pleural mesothelioma(MPM).Methods Seventy-nine patients with MPM treated in Beijing Cancer Hospital from June 1996

  5. Risk Factors Analysis on Traumatic Brain Injury Prognosis

    Institute of Scientific and Technical Information of China (English)

    Xiao-dong Qu; Resha Shrestha; Mao-de Wang

    2011-01-01

    To investigate the independent risk factors of traumatic brain injury (TBI) prognosis.Methods A retrospective analysis was performed in 885 hospitalized TEl patients from January 1,2003 to January 1, 2010 in the First Affiliated Hospital of Medical College of Xi' an Jiaotong University. Single-factor and logistic regression analysis were conducted to evaluate the association of different variables with TBI outcome.Results The single-factor analysis revealed significant association between several variables and TEl outcome, including age (P=0.044 for the age group 40-60, P<0.001 for the age group ≥60), complications (P<0.001), cerebrospinal fluid leakage (P<0.001), Glasgow Coma Scale (GCS) (P<0.001), pupillary light reflex (P<0.001), shock (P<0.001), associated extra-cranial lesions (P=0.01), subdural hematoma (P<0.001), cerebral contusion (P<0.001), diffuse axonal injury (P<0.001), and subarachnoid hemorrhage (P<0.001), suggesting the influence of those factors on the prognosis of TBI. Furthermore, logistic regression analysis identified age, GCS score, pupillary light reflex, subdural hematoma, and subarachnoid hemorrhage as independent risk factors of TEl prognosis.Conclusion Age, GCS score, papillary light reflex, subdural hematoma, and subarachnoid hemorrhage may be risk factors influencing the prognosis of TEl. Paying attention to those factors might improve the outcome of TBI in clinical treatment.

  6. CYTOKINE PROFILE IN VISCERAL OBESITY AND ADVERSE CARDIOVASCULAR PROGNOSIS OF MYOCARDIAL INFARCTION

    Directory of Open Access Journals (Sweden)

    O. V. Gruzdeva

    2015-06-01

    Full Text Available Presence of myocardial infarction in patients with obesity can lead to an uncontrolled increase in proinflammatory cytokines and unfavorable course of the pathological process. Objective: to study the relationship of key inflammatory factors and the development of complications at different terms after myocardial infarction in patients with visceral obesity. The study involved 94 men with myocardial infarction. Visceral obesity was diagnosed by multi-slice computed tomography (LightspeedVCT 64 ,General Electric,USA. On the 1st and 12th day of hospitalization, we determined serum concentrations of interleukins (TNFα, IL-1β, IL-6, IL-8 IL-10 and IL-12, and C-reactive protein. Adverse cardiovascular events were documented during the next year. The most informative indicators were identified by a stepwise logistic regression analysis. In patients with myocardial infarction an imbalance of cytokine profile revealed, i.e., an increase in proinflammatory markers (TNFα, IL-1β, IL-6, IL-8, IL-12, CRP, along with decrease in IL-10, being more pronounced in cases of visceral obesity. Among the studied markers, closest relationship was observed between visceral obesity and serum concentrations of IL-6 and CRP. Over the year, adverse cardiovascular events proved to be more frequent in patients with visceral obesity. Post-infarction complication risk was associated with higher concentrations of IL-6, IL-12 and IL-10 deficiency. Hence, development of adverse cardiovascular events within a year after myocardial infarction is more typical to the patients with visceral obesity, and is accompanied by activation of proinflammatory cytokines and IL-10 deficiency.

  7. [Prognosis factors of cholangiocarcinoma: contribution of recent molecular biology tools].

    Science.gov (United States)

    Malouf, G; Dreyer, C; Guedj, N; Paradis, V; Degos, F; Belghiti, J; Le Tourneau, C; Faivre, S; Raymond, E

    2009-04-01

    Cholangiocarcinoma represents the second most common primary hepatobiliary cancer. Although few patients are candidates for surgery, surgical resection represents the only potential curative option. The prognosis for patients remains poor, despite advances in the understanding of mechanisms involved in carcinogenesis. This review aims to assess clinicopathological factors and biological markers for the ability to predict prognosis. Clinicopathologic factors most often cited are tumor size, lymph node involvement, resecability and surgical margins involvement. Molecular biomarkers have been examined and a number of these, including mdm2, p27, matrix metalloproteinases and vitamin D receptor appear to have prognostic utility. The advent of 'omic'-based profiling offers the potential to assess many different biomarkers at the same time. This 'protein/gene signature' could open the way for developing valid and reproducible predictors of survival based on protein or gene profiles. PMID:19357015

  8. SULFs in human neoplasia: implication as progression and prognosis factors

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    Schved Jean-François

    2011-05-01

    Full Text Available Abstract Background The sulfation pattern of heparan sulfate chains influences signaling events mediated by heparan sulfate proteoglycans located on cell surface. SULF1 and SULF2 are two endosulfatases able to cleave specific 6-O sulfate groups within the heparan chains. Their action can modulate signaling processes, many of which with key relevance for cancer development and expansion. SULF1 has been associated with tumor suppressor effects in various models of cancer, whereas SULF2 dysregulation was in relation with protumorigenic actions. However, other observations argue for contradictory effects of these sulfatases in cancer, suggesting the complexity of their action in the tumor microenvironment. Methods We compared the expression of the genes encoding SULF1, SULF2 and heparan sulfate proteoglycans in a large panel of cancer samples to their normal tissue counterparts using publicly available gene expression data, including the data obtained from two cohorts of newly-diagnosed multiple myeloma patients, the Oncomine Cancer Microarray database, the Amazonia data base and the ITTACA database. We also analysed prognosis data in relation with these databases. Results We demonstrated that SULF2 expression in primary multiple myeloma cells was associated with a poor prognosis in two independent large cohorts of patients. It remained an independent predictor when considered together with conventional multiple myeloma prognosis factors. Besides, we observed an over-representation of SULF2 gene expression in skin cancer, colorectal carcinoma, testicular teratoma and liver cancer compared to their normal tissue counterpart. We found that SULF2 was significantly over-expressed in high grade uveal melanoma compared to low grade and in patients presenting colorectal carcinoma compared to benign colon adenoma. We observed that, in addition to previous observations, SULF1 gene expression was increased in T prolymphocytic leukemia, acute myeloid leukemia

  9. Prognosis and prognostic factors in inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    Thompson Nicholas

    1995-01-01

    Full Text Available The chance of normal survival for patients with inflammatory bowel disease is generally good. There may be a small excess mortality for those with Crohn′s disease; however recent studies do not confirm this trend. For those with ulcerative colitis, there may be an excess mortality in the first two years after diagnosis, especially in those who undergo surgery. The necessity for an operation varies, but at least 50% of patients with Crohn′s disease will be an operation in the first 10 years; whereas only about 20% of patients with ulcerative colitis will require a colectomy. Most patients with inflammatory bowel disease are able to lead a normal life and are not disabled by their disease. The prognosis in the elderly is usually good; however there is an increased mortality over younger patients, which is probably due to the presence of coexistent disease. Children also have a slightly higher mortality; this may be due to the relative frequency of a particularly extensive disease and the development of colorectal cancer. Growth retardation occurs in up to one-third of children with Crohn′s disease, but it may be resol" d if remission can be obtained. Pregnancy has not been shown to have an impact on inflammatory bowel disease, but its onset during pregnancy confers a significant risk for both mother and child. Extensive involvement is a poor prognosis factor in both diseases; conversely, isolated small bowel Crohn′s disease and ulcerative proctitis carry particularly good prognoses. A short clinical history, fistulae or abscesses at presentation probably represent an aggressive form of Crohn′s disease. Hypoalbuminemia, anemia and raised inflammatory markers are laboratory markers which suggest a worse prognosis in the short and possibly long-term.

  10. Subarachnoid hemorrhage of unknown origin: prognosis and prognostic factors.

    Science.gov (United States)

    Brismar, J; Sundbärg, G

    1985-09-01

    The cases of 127 consecutive patients with subarachnoid hemorrhage (SAH), in whom cerebral panangiography revealed no cause for the bleeding nor any sign of an intraparenchymatous hemorrhage, were reviewed in a study of the long-term prognosis and the possible prognostic factors in this condition. Data for all 127 patients in the study were obtained, with an average follow-up period of 5.4 years. After the 1st week post-SAH, only three rebleeds had occurred. In all, 80% of the patients had returned to full activity, 91% to at least part-time work; if the patients with hypertension were excluded, these figures rose to 86% and 95%, respectively. Decreased wakefulness on admission related to a slightly poorer prognosis, whereas age and red blood cell count in the cerebrospinal fluid had no prognostic significance. Of those patients who, at the end of the 2nd week following the SAH, were fully awake and had not developed any symptoms of delayed cerebral ischemia (87% of all patients admitted), 88% returned to full activity, 97% to at least part-time work. The survival rate for this group, as well as causes of death, seem to be within the range for normal individuals. It should thus be possible to inform these patients (at least the normotensive ones) of the benignity of their condition, directly after normal angiography. Even among the patients who were able to return to full activity, symptoms attributable to the SAH were common: 22% experienced problems such as frequent headaches, vertigo, irritability, and increased fatigability. PMID:4020460

  11. CYTOKINE PROFILE IN VISCERAL OBESITY AND ADVERSE CARDIOVASCULAR PROGNOSIS OF MYOCARDIAL INFARCTION

    OpenAIRE

    O V Gruzdeva; O. E. Akbasheva; Matveeva, V. G.; Yu. A. Dyleva; E. I. Palicheva; V. N. Karetnikova; D. A. Borodkina; A. N. Kokov; T. S. Fedorova; O. L. Barbarash

    2015-01-01

    Presence of myocardial infarction in patients with obesity can lead to an uncontrolled increase in proinflammatory cytokines and unfavorable course of the pathological process. Objective: to study the relationship of key inflammatory factors and the development of complications at different terms after myocardial infarction in patients with visceral obesity. The study involved 94 men with myocardial infarction. Visceral obesity was diagnosed by multi-slice computed tomography (LightspeedVCT 6...

  12. Risk Factors of Poor Prognosis after Whiplash Injury

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    Samy Suissa

    2003-01-01

    Full Text Available Whiplash, a common injury following motor vehicle crashes, is associated with high costs and a prognosis that is variable and difficult to predict. In this paper, we review findings from the Quebec cohort epidemiological study on predictive factors of recovery from whiplash injury after a motor vehicle crash. We formed a population-based incident cohort of all 4,759 individuals who sustained a whiplash injury resulting from a motor vehicle crash in the province of Québec, Canada, in 1987, and followed these patients for up to seven years. The data were obtained from the universal automobile insurance plan (SAAQ that covers all seven million residents of the Province for all vehicular-related injuries. From this cohort, we formed the cohort of 3,014 for whom a police report was completed. For this cohort, we obtained data on crash-related factors directly from the police report. We also formed the cohort of 2,627 subjects who had strictly a whiplash injury, without associated injuries. For this cohort, the data on signs and symptoms were obtained from the medical charts kept by the SAAQ. For both cohorts, data on the outcome, the recovery time from whiplash, was obtained from the SAAQ databases. The crash-related cohort study found that socio-demographic factors associated with a longer recovery from whiplash include older age, female sex, having dependents and not being employed full time and that each decreases the rate of recovery by 14 to 16 per cent. Factors related to the crash conditions indicate that being in a truck or bus, with a decrease of 52% in the rate of recovery, being a passenger in the vehicle (15%, colliding with a moving vehicle (16%, and a side or frontal collision (15% all decrease the rate of recovery. We introduce a combined risk score that predicts longer recovery. In the cohort of subjects with signs and symptoms, the median recovery time was 32 days and 12% of subjects had still not recovered after 6 months. The signs

  13. Adverse Pregnancy Outcomes and Cardiovascular Risk Factor Management

    OpenAIRE

    Mehta, Puja K.; Minissian, Margo; Merz, C. Noel Bairey

    2015-01-01

    Cardiovascular disease (CVD) is the leading health threat to American women. In addition to established risk factors for hypertension, hyperlipidemia, diabetes, smoking, and obesity, adverse pregnancy outcomes (APOs) including pre-eclampsia, eclampsia, and gestational diabetes are now recognized as factors that increase a woman’s risk for future CVD. CVD risk factor burden is disproportionately higher in those of low socioeconomic status and in ethnic/racial minority women. Since younger wome...

  14. Aquaporin 1 protein expression is associated with BRAF V600 mutation and adverse prognosis in cutaneous melanoma.

    Science.gov (United States)

    Imrédi, Eleonóra; Tóth, Béla; Doma, Viktória; Barbai, Tamás; Rásó, Erzsébet; Kenessey, István; Tímár, József

    2016-06-01

    Despite experimental findings suggesting the prognostic significance of Aquaporin 1 (AQP1) in human melanoma, no published clinical data are available. We studied the expression of AQP1 protein in cutaneous melanoma, correlated our findings with standard histological and genetic markers, and long-term clinical follow-up. Our study evaluated the AQP1 protein expression in 78 melanoma patients, representing two predefined risk cohorts using the immune labeling technique with commercially available anti-AQP1 antibodies on routinely formalin-fixed and paraffin-embedded tumor tissue samples. BRAF V600E mutation analyses were carried out successfully in 70 patients using PCR and restriction fragment length polymorphism analyses, followed by confirmatory analysis with the Sanger sequencing technique. AQP1-expressing melanoma cells were found in 52 cases (66.7%, median H-score=124.24). Significantly higher AQP1 H-scores (P=0.047) were found in the 'high-risk' patients. No correlations were found with the established histological markers, such as mitotic index (P=0.42), Clark level (P=0.95), and Breslow thickness (P=0.51). BRAF V600 mutation analyses were successful in 89%, and showed a two times higher mutation frequency in the 'high-risk' group. The BRAF V600 mutations were significantly associated with AQP1 expression (P=0.014). Long-term follow-up indicated a reduced progression-free survival (P=0.036) and overall survival (P=0.017) for the AQP1-positive cutaneous melanoma patients. AQP1 expression is likely to be associated with an adverse prognosis in cutaneous melanoma. PMID:26848795

  15. Antenatal psychosocial risk factors associated with adverse postpartum family outcomes.

    OpenAIRE

    Wilson, L. M.; Reid, A. J.; Midmer, D. K.; Biringer, A; Carroll, J C; Stewart, D.E.

    1996-01-01

    OBJECTIVE: To determine the strength of the association between antenatal psychosocial risk factors and adverse postpartum outcomes in the family, such as assault of women by their partner, child abuse, postpartum depression, marital dysfunction and physical illness. DATA SOURCES: MEDLINE, Cinahl, Famli, Psych Abstracts and the Oxford Database of Perinatal Trials were searched from relevant articles published from Jan. 1, 1980, to Dec. 31, 1993, with the use of MeSH terms "depression, involut...

  16. Prognosis of unprotected left main coronary artery stenting and the factors affecting the outcomes in Chinese

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Background The long term prognosis of unprotected left main coronary artery (LMCA) stenting is controversial This study was conducted to evaluate the immediate and long term outcomes of LMCA stenting in Chinese patients and to determine which factors affect the outcomes. Methods From May 1997 to March 2003,224 patients in 23 hospitals underwent elective unprotected LMCA stenting with bare metal stents. Their clinical records were analysed to ascertain immediate and long term outcomes of LMCA stenting as well as factors influencing the prognosis .Results Stents were implanted into LMCA successfully in 223 cases (99.6 %). One death (0.5%) and one case of non-Q wave nonfatal myocardial infarction (MI) occurred in hospital. The mean follow-up time was (15.6±12.3) months. Cardiac death developed in 10 cases (4.5%), noncardiac death in 2 cases (0.9%), nonfatal MI in 4 cases (1.8%), target lesion revascularization (TLR) of LMCA in 26 cases (11.7%) and TLR of nonLMCA in 37 cases (16.5%). Univariate analysis showed that cardiac death correlated with left ventricular ejection fraction (LVEF < 40%), female gender and LMCA combined with multivessel disease; that major adverse cardiac events (MACE) correlated with LVEF < 40%, bifurcation lesion and incomplete revascularization. Logistic regression analysis revealed that LVEF < 40% and female gender were independent predictors of cardiac death and MACE. Follow-up angiography was performed in 102 cases (45.7%). The restenosis rate was 31.4%. Conclusions Long-term outcomes of stenting for selected patients with unprotected LMCA stenosis is acceptable. It should be performed in inoperable or low risk patients with LVEF ≥ 40% and isolated LMCA disease or LMCA combined with multivessel diseases in whom complete revascularization can be obtained.

  17. FACTORS AFFECTING REMOVAL AND PROGNOSIS OF THYMIC TUMORS

    Institute of Scientific and Technical Information of China (English)

    张志庸; 戈烽; 李单青; 李泽坚; 孙成孚; 徐乐天; 张世农

    1995-01-01

    One hundred and ten cases of thymic tumors were intervened surgically, including 92 thymoma, 8 thymie earcinoid, and 10 thymic carcinoma. In this series, 50. 9 % of the cases were complicated with various syndromes, 44. 5 % with myasthenia gravis (MG). Resection rate was correlated with the size and invasion of the tumor. There was significant difference in resection rate among thymoma, thymic carcinoid and thymic carcinoma. The degree of invasiorl undoubtely influenced on resection. The 3-, 5- and 10- year suvival rate of the thymoma were 82. 7 %, 68. 1 % and 40. 0 %, respectively. The prognosis depended on the pathoioglcal classification and the severity of the neighbouring invasion, but MG had no sianificant effect on prognosis. Recurrence and metastasis of the tumor were the main cause of late death.

  18. Short-term prognosis and risk factors of ventricular septal rupture following acute myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    胡小莹

    2013-01-01

    Objective To analyze the short-term prognosis and risk factors of ventricular septal rupture(VSR)following acute myocardial infarction(AMI).Methods A total of 70 consecutive VSR patients following AMI hospitalized in

  19. Short-term prognosis and risk factors of ventricular septal rupture following acute myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    胡小莹

    2013-01-01

    Objective To analyze the short-term prognosis and risk factors of ventricular septal rupture(VSR)following acute myocardial infarction(AMI).Methods A total of 70 consecutive VSR patients following AMI

  20. RISK FACTOR PROFILES OF ADVERSE NEUROMOTOR OUTCOME IN INFANTS

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    Farin SOLEIMANI

    2011-02-01

    Full Text Available ObjectiveAssessment of risk predictors for adverse neurodevelopmental outcome at 1 year of age in term and near-term infants.Material & MethodsThis case-control study was a representative sample of infants from different health-care centers of north and east of Tehran. The association betweenrisk factors and delayed motor development (developmental quotient below 70 indicating a significant delay was analyzed using correlating risk factors;including the perinatal and neonatal data to the developmental status. The case group consisted of 143 infants whose DQ score was less than 70 and thecontrol group consisted of 140 infants who had a DQ score of more than 70.ResultsNeonatal seizures, Apgar score less than 3 after 5 minutes of birth (OR = 2.87 [95% CI; 1.68, 4.92], low birth weight (OR = 5.86 [95% CI; 3.07, 11.18], pretermdelivery (OR =6.17 [95% CI; 3.04, 12.52], Premature rupture of membranes (PROM>24 hours (OR = 6.18[95% CI; 2.07, 18.51] and hyperbilirubinemialeading to phototherapy or exchange transfusion (OR =3.75 [95% CI; 2.12, 6.65] were associated with an increased risk for neuromotor delay on developmentalexamination at 1 year.ConclusionThis study identified distinct risk factors for an adverse outcome in infants. In this environment, perinatal risk predictors are most important.Keywords: Neurodevelopmental outcome, perinatal period, infant, risk factor.

  1. RISK FACTOR PROFILES OF ADVERSE NEUROMOTOR OUTCOME IN INFANTS

    Directory of Open Access Journals (Sweden)

    Farin Soleimani MD

    2010-12-01

    Full Text Available ObjectiveAssessment of risk predictors for adverse neurodevelopmental outcome at 1 year of age in term and near-term infants.Material & MethodsThis case-control study was a representative sample of infants from different health-care centers of north and east of Tehran. The association betweenrisk factors and delayed motor development (developmental quotient below 70 indicating a significant delay was analyzed using correlating risk factors;including the perinatal and neonatal data to the developmental status. The case group consisted of 143 infants whose DQ score was less than 70 and thecontrol group consisted of 140 infants who had a DQ score of more than 70.ResultsNeonatal seizures, Apgar score less than 3 after 5 minutes of birth (OR = 2.87 [95% CI; 1.68, 4.92], low birth weight (OR = 5.86 [95% CI; 3.07, 11.18], pretermdelivery (OR =6.17 [95% CI; 3.04, 12.52], Premature rupture of membranes (PROM>24 hours (OR = 6.18[95% CI; 2.07, 18.51] and hyperbilirubinemialeading to phototherapy or exchange transfusion (OR =3.75 [95% CI; 2.12, 6.65] were associated with an increased risk for neuromotor delay on developmentalexamination at 1 year.ConclusionThis study identified distinct risk factors for an adverse outcome in infants. In this environment, perinatal risk predictors are most important.

  2. Analysis of Adverse Events in Identifying GPS Human Factors Issues

    Science.gov (United States)

    Adams, Catherine A.; Hwoschinsky, Peter V.; Adams, Richard J.

    2004-01-01

    The purpose of this study was to analyze GPS related adverse events such as accidents and incidents (A/I), Aviation Safety Reporting System (ASRS) reports and Pilots Deviations (PDs) to create a framework for developing a human factors risk awareness program. Although the occurrence of directly related GPS accidents is small the frequency of PDs and ASRS reports indicated there is a growing problem with situational awareness in terminal airspace related to different types of GPs operational issues. This paper addresses the findings of the preliminary research and a brief discussion of some of the literature on related GPS and automation issues.

  3. Ceratocone: fatores prognósticos Keratoconus: prognosis factors

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    Rosana Molina Saraiva Elias

    2005-08-01

    keratoconus disease carrier patients in an age range under the usual one and try to detect any factor which can influence in disease evolution and prognosis. METHODS: Patients under 15 years old with a keratoconus diagnosis where analyzed. All of them answered a questionnaire, and were submitted to ocular examination and also computerized ceratoscopy. These patients were divided into three groups and went through a contact lens test: 1 it was possible for this group to adapt to contact lenses; 2 a cornea transplant for this group was recommended; 3 for this group it was suggested that they use glasses. RESULTS: Patients who had 20/40 or greater visual acuity usually did not progress to transplant in the studied period. On the other hand, patients who had 20/60 or less acuity, progress to a deep transplant very quickly. Other cases, related to a lower age range (10-15 years old pregressed to a transplant. We can observe that the cornea apex has a very unsteady location, which explains the different difficulty levels regarding adaptation to contact lenses. In all patients who had a superior out of place apex and values greater than 66 D adaptation was successful. In the central apex eyes the adaptation was easier. In the inferior apex eyes it was not possible to set a standard to indicate the person for surgery. In the eyes which were adapted to the contact lenses and whose curvature was smaller than 51.10 D there were fewer chances of evolution to a cornea transplant, on comparison with patients who had a curvature of 57.60 or even greater. CONCLUSION: Patients who have curvatures greater than 57.40, acuity lower than 20/60 and are under 18 years old have more chances to evolve to a cornea transplant. When the ceratocone apex is central the contact lens adaptation becomes easier.

  4. Inflammation-based factors and prognosis in patients withcolorectal cancer

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Several parameters for predicting survival in patientswith colorectal cancer have been identified, includingthe performance status, age, gender and tumor-nodemetastasis(TNM) stage. Although the TNM stage isimportant and useful for predicting the prognosis anddetermining the appropriate treatment, it is well knownthat the survival time varies widely, even in patients withthe same stage of disease. Therefore, the identificationof new parameters capable of more precisely predictingpatient survival is needed to help select the optimaltreatment, especially in patients in the advanced stageof disease. Although the TNM stage reflects the tumorcharacteristics, cancer progression and survival are notdetermined solely based on the local characteristics ofthe tumor, but also the host systemic immune/inflammatoryresponse. Therefore, using a combination ofparameters that reflect both tumor characteristics andthe host systemic inflammatory status is thought to beimportant for accurately predicting patient survival.

  5. Expression of Myeloid Antigen in Neoplastic Plasma Cells Is Related to Adverse Prognosis in Patients with Multiple Myeloma

    OpenAIRE

    Hyoeun Shim; Joo Hee Ha; Hyewon Lee; Ji Yeon Sohn; Hyun Ju Kim; Hyeon-Seok Eom; Sun-Young Kong

    2014-01-01

    We evaluated the association between the expression of myeloid antigens on neoplastic plasma cells and patient prognosis. The expression status of CD13, CD19, CD20, CD33, CD38, CD56, and CD117 was analyzed on myeloma cells from 55 newly diagnosed patients, including 36 men (65%), of median age 61 years (range: 38–78). Analyzed clinical characteristics and laboratory parameters were as follows: serum β 2-microglobulin, lactate dehydrogenase, calcium, albumin, hemoglobin, serum creatinine conce...

  6. Prognosis and risk factors for intrauterine growth retardation

    DEFF Research Database (Denmark)

    Sehested, Line Thousig; Pedersen, Pernille

    2014-01-01

    focusing on risk factors, catch up and neonatal outcome. MATERIAL AND METHODS: This was a retrospective descriptive study of IUGR neonates with a birth weight below 70% of the expected whose mothers were admitted to the Neonatal Ward at Hvidovre Hospital during 2007-2009. Obstetrical and maternal risk...... factors and neonatal growth and outcome at six weeks, five months and 12 months of age were collected. RESULTS: A total of 73 neonates and their mothers were included. Caesarean delivery was given in 78% of the cases. Maternal risk factors included gestational hypertension (33%), smoking (24%) and...... placental infarction (17%). Hypoglycaemic episodes developed in 31% of the neonates. At 12 months, 90% had caught up growth and 7% had a neurologically poor outcome. No infants died. CONCLUSION: Maternal smoking and gestational hypertension are important risk factors for the development of IUGR. Special...

  7. Analysis of related factors affecting prognosis of shunt surgery in patients with secondary normal pressure hydrocephalus

    Institute of Scientific and Technical Information of China (English)

    WANG Cheng; DU Hang-gen; YIN Li-chun; HE Min; ZHANG Guo-jun; TIAN Yong; HAO Bi-lie

    2013-01-01

    Objective:The management of secondary normal pressure hydrocephalus (sNPH) is controversial.Many factors may affect the surgery effect.The purpose of this study was to identify the possible factors influencing prognosis and provide theoretical basis for clinical treatment of sNPH.Methods:A retrospective study was carried out to investigate the results of 31 patients with sNPH who underwent ventriculoperitoneal shunt surgery from January 2007 to December 2011.We processed the potential influencing factors by univariate analysis and the result further by multivariate logistic regression analysis.Results:Factors including age,disease duration and Glasgow coma scale (GCS) score before surgery significantly influenced the prognosis of sNPH (P<0.05).Further logistic regression analysis showed that all the three factors are independent influencing factors.Conclusion:Age,disease duration and GCS score before surgery have positive predictive value in estimating favorable response to surgical treatment for sNPH.

  8. Retinopathy of Prematurity; Risk Factors, Prognosis and Treatment

    Directory of Open Access Journals (Sweden)

    Sibel Kocabeyo¤lu

    2011-06-01

    Full Text Available Purpose: To evaluate the prevalence, related risk factors, treatment and follow-up results in cases of retinopathy of prematurity (ROP. Material and Method: Medical records of 405 premature infants who attended our clinic between August 1999 and September 2004 were retrospectively screened. Among these patients, 379 infants were followed up in our neonatology unit and 26 were referred to us from other clinics. Indirect diode laser photocoagulation and/or cryotherapy were performed when prethreshold or threshold ROP was detected. Surgery was performed in stage IV-V ROP. Results: ROP was detected in 88 out of 405 infants (21.72%. At the first examination, stage I ROP was detected in 18 eyes (10.4%, stage II - in 67 eyes (38.72%, stage III - in 82 eyes (47.39%, and stage IV-V – in 6 eyes (3.46%. Indirect diode laser photocoagulation was applied to 34 eyes with stage II and in 47 eyes with stage III ROP. Ten eyes with threshold ROP and 4 eyes which progressed to threshold ROP were treated with cryotherapy. Scleral buckling was performed in 3 eyes that progressed to stage IV ROP. At the first examination, 2 eyes with stage IV-V ROP were treated with pars plana vitrectomy (PPV. Discussion: In our series, the most important risk factors for development and progression of ROP were found to be low birth weight, low gestational age, mechanical ventilation and multiple pregnancy. Effective screening, follow-up and appropriate treatment are important for prevention of permanent damage and unfavorable outcome in ROP. (Turk J Ophthalmol 2011; 41: 128-32

  9. Analysis of the risk factors for the short-term prognosis of acute ischemic stroke

    OpenAIRE

    Liang, Jin; Liu, Wenbo; Sun, Jianping; Gu, Xinyi; MA, QIANG; Tong, Weijun

    2015-01-01

    This study investigated the risk factors for the short-term prognosis of acute ischemic stroke to provide a scientific evidence for improving prevention and treatment. A total of 2557 cases of acute ischemic stroke were included in the study. We collected the data on demographic characteristics, life style-related risk factors, clinical feature, and other clinical characteristics for all the participants. The outcomes were assessed using the modified Rankin scale (mRs) on day 14 or at dischar...

  10. Risk Factors and Prognosis of Lung Cancer Combined with Pulmonary Embolism

    OpenAIRE

    Wang, Jun; Zhou, Weihua; Xu, Lin; Yang, Min; Lijuan MENG; Weifei FAN; Pu, Xiaolin; Yang, Yuanhua

    2011-01-01

    Background and objective Malignant tumors often combined with venous thrombosis and pulmonary embolism, especially in lung cancer. It has been proven that, the mechanisms and risk factors for lung cancer patients contracting pulmonary embolism are unclear. The aim of this study is to summarize the clinical data on 54 patients with lung cancer and concomitant pulmonary embolism, and to analyze the risk factors and prognosis of lung cancer with pulmonary thromboembolism (PTE). Methods From Apri...

  11. Viral and host inflammation-related factors that can predict the prognosis of hepatocellular carcinoma.

    Science.gov (United States)

    Chen, Liping; Zhang, Qi; Chang, Wenjun; Du, Yan; Zhang, Hongwei; Cao, Guangwen

    2012-09-01

    Hepatocellular carcinoma (HCC), a malignancy caused mainly by chronic infection with hepatitis B virus (HBV) and/or hepatitis C virus (HCV), is a highly fatal disease. Apart from clinical parameters like venous invasion and multinodularity, viral and host inflammation-related factors are important predictors of HCC prognosis after surgical treatment. The factors of prognostic value can be detected in the specimens of HCC patients. In preoperative peripheral blood, high HBV DNA and the genotypes and mutations of HBV or HCV, high neutrophil-to-lymphocyte ratio and high concentrations of macrophage migration inhibitory factor and osteopontin predict poor prognosis. In tumours, high ratios of neutrophil-to-CD8(+) T cell and Treg-to-CD8(+) T cell, high expression of pro-angiogenic factors such as hypoxia-inducible factor-1α and cell growth/survival factors such as CD24 and activation of inflammatory signalling pathways such as Wnt/β-catenin, nuclear factor-kappa B and signal transducer and activator of transcription 3 predict early recurrence. In peritumoural hepatic tissues, high HBV DNA, HBV mutations, high densities of macrophages, activated stellates and mast cells, high expression of macrophage colony-stimulating factor/its receptor and placental growth factor, Th1/Th2-like cytokine shift, inflammation-related signature and activation of carcinogenesis-related pathways predict late recurrence. Further studies should be focused on the development of a robust strategy by integrating the viral factors, inflammatory factors and clinical factors of complementary prognostic value to ensure high validity of the assessment for postoperative HCC prognosis. PMID:22325840

  12. Adverse Reaction to Cetuximab, an Epidermal Growth Factor Receptor Inhibitor.

    Science.gov (United States)

    Štulhofer Buzina, Daška; Martinac, Ivana; Ledić Drvar, Daniela; Čeović, Romana; Bilić, Ivan; Marinović, Branka

    2016-04-01

    Dear Editor, Inhibition of the epidermal growth factor receptor (EGFR) is a new strategy in treatment of a variety of solid tumors, such as colorectal carcinoma, non-small cell lung cancer, squamous cell carcinoma of the head and neck, and pancreatic cancer (1). Cetuximab is a chimeric human-murine monoclonal antibody against EGFR. Cutaneous side effects are the most common adverse reactions occurring during epidermal growth factor receptor inhibitors (EGFRI) therapy. Papulopustular rash (acne like rash) develop with 80-86% patients receiving cetuximab, while xerosis, eczema, fissures, teleangiectasiae, hyperpigmentations, and nail and hair changes occur less frequently (2). The mechanism underlying these skin changes has not been established and understood. It seems EGFRI alter cell growth and differentiation, leading to impaired stratum corneum and cell apoptosis (3-5). An abdominoperineal resection of the rectal adenocarcinoma (Dukes C) was performed on a 43-year-old female patient. Following surgery, adjuvant chemo-radiotherapy was applied. After two years, the patient suffered a metastatic relapse. Abdominal lymphadenopathy was detected on multi-slice computer tomography (MSCT) images, with an increased value of the carcinoembryonic antigen (CEA) tumor marker (maximal value 57 ng/mL). Hematological and biochemical tests were within normal limits, so first-line chemotherapy with oxaliplatin and a 5-fluorouracil (FOLFOX4) protocol was introduced. A wild type of the KRAS gene was confirmed in tumor tissue (diagnostic prerequisite for the introduction of EGFRI) and cetuximab (250 mg per m2 of body surface) was added to the treatment protocol. The patient responded well to the treatment with confirmed partial regression of the tumor formations. Three months after the patient started using cetuximab, an anti-EGFR monoclonal antibody, the patient presented with a papulopustular eruption in the seborrhoeic areas (Figure 1) and eczematoid reactions on the extremities

  13. A Research on Factors Influencing the Clinical Prognosis of Acute Stroke Patie.patients

    Institute of Scientific and Technical Information of China (English)

    Luo Zuming; Li Manli

    2000-01-01

    Object: To search for the factors significantly influencing the clinical prognosis of acute stroke patients. Background: There are lack of prospective multivariate analysis research m acute stroke in the world. Method: We chose 17 factors possibly influencing the prognosis of acute patients, took Barthel′s Index at the end of 2 months after stroke onset and decreased percentage of neurological deficit scores (MESSS) between 72h after hospitalization and 2 months after onset as gold standard, to have a prospective, multivariate analysis research combined with univariate analysis. Results: Multivariate analysis of 106 acute stroke patients combined with univariate analysis showed the factors significantly influencing the clinical prognosis of acute stroke patients were: initial MESSS score、 age、 complication、 mass effect、 stroke location、 time of delay before emergency arrival (BDT). Time of delay after emergency arrival was not found to be a significant prognostic factor. Discussion: Barthel Index at the end of 1 month after stroke onset was strongly related to that at the end of 2 month after onset, as was the same with MESSS score. It showed there was no significant difference between 1 month and 2 months after stroke onset when we choose time interval in evaluating prognosis of acute stroke patients.Conclusion: BDT、 initial MESSS score、 age、 stroke location、 mass effect、 complication were important factors of acute stroke patients. Avoid the delay before emergency arrival after onset, prevent and treat complications after stroke, more carefully treat acute stroke patients with advanced age, advanced age, high initial MESSS scores and those with mass effect reported by CT, we can improve the outcome of stroke patients.

  14. Analysis of risk factors affecting the prognosis of pancreatic neuroendocrine tumors

    Institute of Scientific and Technical Information of China (English)

    Tao Ming; Yuan Chunhui; Xiu Dianrong; Shi Xueying; Tao Liyuan; Ma Zhaolai; Jiang Bin

    2014-01-01

    Background Pancreatic neuroendocrine tumors (pNETs) are a type of tumors with the characteristics of easy metastasis and recurrence.Till date,the risk factors affecting the prognosis are still in the debate.In this study,several risk factors will be discussed combined with our cases and experience.Methods Thirty-three patients diagnosed as pNETs were enrolled and the clinical features,blood tests,pathological features,surgical treatment,and follow-up data of these patients were collected and analyzed.Results In this study,operation time of G3 cases was longer than G1/G2 cases (P=0.017).The elevated level of tumor markers such as AFP,CEA,Ca125,and Ca19-9 may predict easier metastasis,earlier recurrence,and poor prognosis (P=0.007).The presence of cancer embolus and nerve invasion increases along with the TNM stage (P=0.037 and P=0.040),and the incidence of positive surgical margin increased (P=0.007).When the presence of nerve invasion occurs,the chance of cancer embolus and lymph node metastasis also increases (P=0.016 and P=0.026).Conclusions pNETs were tumors with the features of easy recurrence and metastasis and many risk factors could affect its prognosis such as the elevated levels of tumor markers and the presence of nerve invasion,except some recognized risk factors.If one or more of these factors existed,postoperative treatments may be needed to improve prognosis.

  15. Self-immolation and its adverse life-events risk factors: results from an Iranian population

    OpenAIRE

    Alireza Ahmadi; Schwebel, David C.; Shahrzad Bazargan-Hejazi

    2015-01-01

    Abstract: Background: Despite considerable loss of life by deliberate self-burning in low and middle-income countries, few scholars have examined psychiatric factors such as adverse life events that may be related to self-immolation. Methods: This case-control study investigated adverse life-events as risk factors for self-immolation patients admitted to a burn center serving the western region of Iran. Variables inves-tigated included the following adverse life-events: unplanned pregna...

  16. Long-Term Prognosis and Factors Affecting Biliary Atresia from Experience over A 25 Year Period

    OpenAIRE

    Hong-Shiee Lai; Wei-Jao Chen; Chiu-Ching Chen; Wen-Tsung Hung; Mei-Hwei Chang

    2006-01-01

    Background: The purpose of this study was to delineate the long-term prognosis and factorswe have noted in our 25 years of experience treating patients sufferingfrom biliary atresia (BA) who have undergone Kasai’s operation.Methods: We studied 141 patients (69 male and 72 female infants) who underwentKasai’s operation at the National Taiwan University Hospital between 1976and 2000. Factors analyzed included age at time of surgery, postoperativebile flow, frequency of cholangitis, prophylactic...

  17. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... called prognosis. It can be hard to understand what prognosis means and also hard to talk about, even for doctors. Many Factors Can Affect Your Prognosis Some of the factors that affect prognosis include: The type of cancer and where it is in your ...

  18. Brain-derived neurotrophic factor expression predicts adverse pathological & clinical outcomes in human breast cancer

    Directory of Open Access Journals (Sweden)

    Mokbel Kefah

    2011-07-01

    Full Text Available Abstract Introduction Brain-derived neurotrophic factor (BDNF has established physiological roles in the development and function of the vertebrate nervous system. BDNF has also been implicated in several human malignancies, including breast cancer (BC. However, the precise biological role of BDNF and its utility as a novel biomarker have yet to be determined. The objective of this study was to determine the mRNA and protein expression of BDNF in a cohort of women with BC. Expression levels were compared with normal background tissues and evaluated against established pathological parameters and clinical outcome over a 10 year follow-up period. Methods BC tissues (n = 127 and normal tissues (n = 33 underwent RNA extraction and reverse transcription, BDNF transcript levels were determined using real-time quantitative PCR. BDNF protein expression in mammary tissues was assessed with standard immuno-histochemical methodology. Expression levels were analyzed against tumour size, grade, nodal involvement, TNM stage, Nottingham Prognostic Index (NPI and clinical outcome over a 10 year follow-up period. Results Immuno-histochemical staining revealed substantially greater BDNF expression within neoplastic cells, compared to normal mammary epithelial cells. Significantly higher mRNA transcript levels were found in the BC specimens compared to background tissues (p = 0.007. The expression of BDNF mRNA was demonstrated to increase with increasing NPI; NPI-1 vs. NPI-2 (p = 0.009. Increased BDNF transcript levels were found to be significantly associated with nodal positivity (p = 0.047. Compared to patients who remained disease free, higher BDNF expression was significantly associated with local recurrence (LR (p = 0.0014, death from BC (p = 0.018 and poor prognosis overall (p = 0.013. After a median follow up of 10 years, higher BDNF expression levels were significantly associated with reduced overall survival (OS (106 vs. 136 months, p = 0.006. BDNF

  19. The prognosis and prognostic risk factors of patients with hepatic artery complications after liver transplantation treated with the interventional techniques

    International Nuclear Information System (INIS)

    Objective: To investigate the prognosis and prognostic risk factors of hepatic artery complications after orthotopic liver transplantation (OLT) treated with the interventional techniques. Methods: The clinical data of 21 patients with hepatic artery complication after liver transplantation receiving thrombolysis, PTA, and stent placement in our institute from November 2003 to April 2007 were retrospectively analyzed. Based on the prognosis of grafts, 21 patients were divided into poor-prognosis group and non-poor-prognosis group. Fifteen variables (including biliary complication, hepatic artery restenosis, early or late artery complication, and so on) were analyzed in both groups with binary logistic regression analysis to screen out the risk factors related to prognosis of pereutaneous interventional treatment for hepatic artery complications after OLT. Results: Twenty-one patients were followed for mean 436 days, median 464 days (3-1037 days). The poor-prognosis group included 11 patients (5 cases received retransplantation, and 6 died). The mean survival time of grafts in poor-prognosis group was 191 days, and median survival time was 73 days (3-616 days). The mean survival time of grafts in non-poor-prognosis group which included 10 patients was 706 days, and median survival time was 692 days (245-1037 days). Univariate analysis showed there were significant difference in biliary complication, total bilimbin and indirect bilirubin between the two groups. The binary, logistic regression analysis showed the risk factor related to prognosis was with biliary complication before the interventional management (P=0.027, OR=22.818). Conclusion: Biliary complication before interventional management is the risk factor related to poor prognosis of patients with hepatic artery stenosis or thrombosis receiving interventional treatment. (authors)

  20. Molecular mechanism of biophylaxis for adverse factor in working environment

    International Nuclear Information System (INIS)

    It has been known that there exist some specific proteins in the pathway by which adverse environmental components are transferred to genes mediating the biophylaxis mechanism. Therefore, it seemed that information exchange might be made through interaction between such proteins and unknown proteins, and this step would be the key step of biophylaxis. In this study, construction of a recombinant protein was attempted to develop a detection method for such protein-protein interaction using radioisotopes. First, vectors that can express ZRF protein with S-tag at the N-terminal end in E.coli were constructed (pZRF29, pZRF30) and E.coli transfected with the vector was cultured to collect the recombinant protein. Thus obtained recombinant ZRF protein was analyzed by polyacrylamide gel electrophoresis and detection was made by Coomassie staining. Using the two vectors, ZRF protein was produced. The protein could be obtained at much higher efficiency in the present system than the previous system. However, the expression level of β-galactosidase as the control was still higher than that of the ZRF protein. This would be due to the higher stability of β- galactosidase, suggesting that further improvement might be obtainable by stabilizing the ZRF protein at the time of expression. It was thought necessary to choose the optimum conditions of the system in respects of cell culture and induction of the recombinant protein as well as protein extraction. (M.N.)

  1. The study of risk factors affecting the prognosis of lung abscess

    Directory of Open Access Journals (Sweden)

    Aghajan Zadeh M

    2000-09-01

    Full Text Available In spite the emergence of potent and broad spectrum antibiotics and recent advances in bronchoscopy and pulmonary physiotherapy, still there is a high rate of morbidity and mortality because of lung abscess. The objective of this study is the indication of risk factors, which have undesirable effects on the prognosis of lung abscess. In a retrospective study, all cases of lung abscess who was confined to bed during 1994 to 1999 in Rasht were collected and analyzed. From 52 cases, 40 (77% were male and 12 (23% were female. The mean duration of stay was 20 day (15 to 35. The secondary cause for lung abscess was as follows: 10 cases (19% COPD, 10 cases (19% preumonia, 15 cases (29% bronchiectasia 2 cases lung cancer, 2 cases lung hydatid cyst and 3 cases atelectasia. Extrapulmonary causes of lung abscess were consist of: 10 case (10% aspiration, 10 case (19% esophageal diseases tending to reflux, 5 case (9% periodontal disease. The factors, which had underiable effects on prognosis of disease were lung cancer, anemia, hypoalbuminemia, age over 60, abscess with pseudomonas, abscess cavity greater thus 8 cm, lower lobe in right lung and TB. Because of high mortality and morbidity of lung abscess, due attention for internal drainage, bronchoscopy, physiotherapy and timed surgery are seriously indicated.

  2. Impact of reversionary and other etiological factors on prognosis and course of schizophrenia

    Directory of Open Access Journals (Sweden)

    Ifeta Ličanin

    2010-08-01

    Full Text Available Aim To identify the presence of schizophrenia among patients andtheir relatives, factors affecting duration and prognosis of the disease and other etiological factors related to schizophrenia.Methods This retrospective, descriptive, analytical and epidemiological research, which was conducted at the Psychiatric hospital of the Clinical Center of the University of Sarajevo during 2007, covered randomly selected 100 hospitalized patients with schizophrenia according to diagnostic criteria of the Diagnostic andStatistical Manual of Mental Disorders (DSM-IV. Diagnosis of schizophrenia among relatives was based on anamnesis- Structural Clinical Interview (SCID and it was applied to confirm DSM-IV diagnosis of schizophrenia. Results The presence of schizophrenia among patient relatives was the most important in etiology of schizophrenia (62%, and etiological factors were represented in 38 % of examinees (p=0,0001. Among relatives of examinees aged 20 – 30 years, schizophrenia was present in 37 (59.7% cases. Schizophrenia among relatives caused earlier appearance of the disease. Duration of hospitalization of over 60 days was in the group of examinees which have the relatives with schizophrenia, 18 (29.0%; multiple hospitalizations were noted in the group of relatives in 40 (64.5% cases; in one case (8.3% traumatic experience was noted, in three (42.8% acute stress, and in four 4 cases (28.6% non-adequate living conditions. Conclusions The results of this study show that reversionary factors are responsible for inducing schizophrenia, which leads towards chronic course of the disease and worsened prognosis.

  3. Correlation between vascular endothelial growth factor and long-term prognosis in patients with acute myocardial infarction

    Science.gov (United States)

    NIU, JIAMIN; HAN, XIA; QI, HUAXIN; YIN, JIE; ZHANG, ZHIQIANG; ZHANG, ZENGTANG

    2016-01-01

    The aim of the present study was to investigate the correlation between plasma the levels of vascular endothelial growth factor (VEGF) and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI). A total of 124 patients with AMI undergoing emergency percutaneous coronary intervention (PCI) were selected, and plasma VEGF levels were measured 7 days after the onset of AMI using an enzyme-linked immunosorbent assay. The patients were divided into the L (≤190 pg/ml VEGF) and H (>190 pg/ml VEGF) groups, and were followed up every 2 months for an average of 12 months. MACE were recorded during follow-up. On the basis of these results, the patients were further divided into the MACE and non-MACE (N-MACE) groups, and the serum VEGF concentration was compared between the two groups. At the 6-month follow-up, the incidence of MACE in the H group was found to be significantly reduced compared with the L group. The serum VEGF concentration in the N-MACE group was significantly higher compared with the MACE group. Multinomial logistic regression revealed that reduced VEGF levels (β=1.243; 95% CI, 1.018–1.326; P=0.026) were independent risk factors for MACE. In conclusion, high plasma VEGF levels at 7 days after AMI onset facilitate the long-term prognosis in the same infarct zone in patients with AMI, while low plasma VEGF levels are independent risk factors for MACE. PMID:27347081

  4. Intracerebral hemorrhage during treatment with oral anticoagulants. Risk factors, therapy and prognosis.

    Science.gov (United States)

    Ernestus, R I; Speder, B; Pakos, P; Hildebrandt, G; Klug, N

    1994-01-01

    Intracerebral hemorrhage (ICH) during oral anticoagulation is a serious complication, which is mostly fatal for the multimorbid patient. In the present retrospective study of 53 patients with ICH during treatment with a cumarin derivative (Phenoprocoumon, Marcumar), we investigated the relationship between therapy and preexisting parameters such as age, location, level of consciousness, additional bleeding risks, and the degree of anticoagulation, which were assumed to be of prognostic relevance. The therapeutic management of ICH during treatment with anticoagulants was determined predominantly by location of the hematoma, patient's age, and additional bleeding risks, but less by level of consciousness and initial thromboplastin time (Quick's test). As a consequence of the individual analysis of these 5 parameters, age over 60 years, location of hematoma in the midline or ventricles, coma, additional bleeding risks such as arterial hypertension and trauma, and Quick's test below 15% at the time of bleeding were supposed to be responsible for poor prognosis. Mortality increased with a rising number of poor prognostic factors, independently of surgical or conservative treatment. In consequence, prognosis of ICH during oral anticoagulation is predominantly influenced by the number of such disadvantageous indicators and only little by therapy. PMID:8053274

  5. Fibroblast growth factor receptor 4 promotes progression and correlates to poor prognosis in cholangiocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Yun-Fei [Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University (China); Yang, Xiao-Qing [Department of Pathology, Shandong University (China); Lu, Xiao-Fei [Department of Gastrointestinal Surgery, Jinan Central Hospital (China); Guo, Sen; Liu, Yi; Iqbal, Mohammad; Ning, Shang-Lei; Yang, Hui [Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University (China); Suo, Ning [Department of Anatomy, Shandong University (China); Chen, Yu-Xin, E-mail: yxu8@bidmc.harvard.edu [Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University (China)

    2014-03-28

    Highlights: • FGFR4 is significantly related with N stage in IHCC, with T stage and TNM stage in PHCC. • FGFR4 is an independent prognostic factor in IHCC and PHCC. • FGFR4 promotes proliferation, invasion and EMT in cholangiocarinoma cell lines. • Inhibitor AP24354 can decrease proliferation, invasion and induce apoptosis of CCA. - Abstract: Fibroblast growth factor receptor 4 (FGFR4) is related to poor prognosis of several cancers, but the correlation between FGFR4 expression and cholangiocarcinoma (CCA) has not been well elucidated. We investigated the expression of FGFR4 in 83 intrahepatic cholangiocarcinomas (IHCCs), 75 perihilar cholangiocarcinomas (PHCCs) and 41 distal cholangiocarcinomas (DCCs) by immunohistochemistry (IHC), and subsequently evaluated association of FGFR4 with clinicopathologic parameters and survival rate. The rate of FGFR4 higher expression was 61.4% (51/83) in IHCCs, 53.3% (40/75) in PHCCs and 56.1% (23/41) in DCCs. FGFR4 expression was significantly related to poor prognosis of IHCC (P = 0.002) and PHCC (P = 0.019) with univariate analysis, and also identified as an independent prognostic factor in IHCC (P = 0.045) and PHCC (P = 0.049) with multivariate analysis. Additionally, with functional assays in vitro, we found FGFR4 can induce proliferation, invasion and epithelial–mesenchymal transition (EMT) of CCA cell lines with FGF19 stimulation. Moreover, FGFR4 inhibitor AP24354 can suppress proliferation, invasion and induce apoptosis of CCA cells. In conclusion, FGFR4 expression can be identified as a significant independent prognostic biomarker of IHCC and PHCC. FGFR4 played a pivotal role in proliferation, invasion and EMT of CCA. FGFR4 inhibitor can suppress proliferation, invasion and induce apoptosis of CCA, indicating that FGFR4 may act as a potential therapeutic target.

  6. Fibroblast growth factor receptor 4 promotes progression and correlates to poor prognosis in cholangiocarcinoma

    International Nuclear Information System (INIS)

    Highlights: • FGFR4 is significantly related with N stage in IHCC, with T stage and TNM stage in PHCC. • FGFR4 is an independent prognostic factor in IHCC and PHCC. • FGFR4 promotes proliferation, invasion and EMT in cholangiocarinoma cell lines. • Inhibitor AP24354 can decrease proliferation, invasion and induce apoptosis of CCA. - Abstract: Fibroblast growth factor receptor 4 (FGFR4) is related to poor prognosis of several cancers, but the correlation between FGFR4 expression and cholangiocarcinoma (CCA) has not been well elucidated. We investigated the expression of FGFR4 in 83 intrahepatic cholangiocarcinomas (IHCCs), 75 perihilar cholangiocarcinomas (PHCCs) and 41 distal cholangiocarcinomas (DCCs) by immunohistochemistry (IHC), and subsequently evaluated association of FGFR4 with clinicopathologic parameters and survival rate. The rate of FGFR4 higher expression was 61.4% (51/83) in IHCCs, 53.3% (40/75) in PHCCs and 56.1% (23/41) in DCCs. FGFR4 expression was significantly related to poor prognosis of IHCC (P = 0.002) and PHCC (P = 0.019) with univariate analysis, and also identified as an independent prognostic factor in IHCC (P = 0.045) and PHCC (P = 0.049) with multivariate analysis. Additionally, with functional assays in vitro, we found FGFR4 can induce proliferation, invasion and epithelial–mesenchymal transition (EMT) of CCA cell lines with FGF19 stimulation. Moreover, FGFR4 inhibitor AP24354 can suppress proliferation, invasion and induce apoptosis of CCA cells. In conclusion, FGFR4 expression can be identified as a significant independent prognostic biomarker of IHCC and PHCC. FGFR4 played a pivotal role in proliferation, invasion and EMT of CCA. FGFR4 inhibitor can suppress proliferation, invasion and induce apoptosis of CCA, indicating that FGFR4 may act as a potential therapeutic target

  7. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... chances of survival. The estimate of how the disease will go for you is called prognosis. It can be hard to understand what prognosis means and also hard to talk about, even for doctors. Many Factors Can Affect Your Prognosis Some of the factors that affect ...

  8. Causal Factors Influencing Adversity Quotient of Twelfth Grade and Third-Year Vocational Students

    Directory of Open Access Journals (Sweden)

    Rachapoom Pangma

    2009-01-01

    Full Text Available Problem statement: The aim of this research was to study the causal factors influencing students’ adversity between twelfth grade and third-year vocational students in Sisaket province, Thailand. Six hundred and seventy two of twelfth grade and 376 third-year vocational students were selected by multi-stage random sampling techniques. Approach: The instruments used for collecting data were: A scale on self-esteem, a scale on dominance, a scale on self-confidence, a scale on sense of personal freedom, a scale on achievement motivation, a scale on ambition, a scale on enthusiasm, a scale on responsibility, a scale on future orientation, and an adversity quotient scale. The data were analyzed by validity test of the causal relationship model. Results: The results of the study were as follows: (1 variables influencing the adversity quotient of 12th grade and third-year vocational students were dominance, sense of personal freedom, self-esteem, enthusiasm, self-confidence, ambition and achievement motivation. (2 Variables are directly influencing the adversity quotient of twelfth grade students was self-confidence while the variables both directly and indirectly influencing the adversity quotient of students were dominance, sense of personal freedom, self-esteem, and enthusiasm. (3 Variable are directly influencing adversity quotient of third-year vocational students was achievement motivation, the variables are indirectly influencing the adversity quotient of these students was dominance while the variables both directly and indirectly influencing the adversity quotient of these students were sense of personal freedom, self-esteem, enthusiasm, self-confidence, and ambition. Conclusion: In conclusion, the results of this study could be used as beneficial information for parents, teachers and those involved in education for developing students to have adversity quotient as well as to be used as guidelines for providing education in the future.

  9. Prognosis and risk factors for deterioration in patients admitted to a medical emergency department

    DEFF Research Database (Denmark)

    Henriksen, Daniel Pilsgaard; Brabrand, Mikkel; Lassen, Annmarie Touborg

    2014-01-01

    OBJECTIVE: Patients that initially appear stable on arrival to the hospital often have less intensive monitoring of their vital signs, possibly leading to excess mortality. The aim was to describe risk factors for deterioration in vital signs and the related prognosis among patients with normal...... presentation, 1440/4292 (33.6%) had all normal vital signs and were included in study, 44.0% were male, median age 64 years (5th/95th percentile: 21-90 years) and 446/1440 (31.0%) deteriorated within 24 hours. Independent risk factors for deterioration included age 65-84 years odds ratio (OR): 1.79 (95.......2-3.0%) among the non-deteriorating, hazard ratio 4.11 (95% CI: 2.38-7.10). CONCLUSIONS: Among acutely admitted medical patients who arrive with normal vital signs, 31.0% showed signs of deterioration within 24 hours. Risk factors included old age, Do-not-attempt-to-resuscitate order, admission from the open...

  10. RISK FACTORS AND PROGNOSIS OF EPILEPSY IN CHILDREN WITH HEMIPARETIC CEREBRAL PALSY

    Directory of Open Access Journals (Sweden)

    Parvaneh KARIMZADEH

    2010-12-01

    Full Text Available ObjectiveEpilepsy is reported in 15-90% of the children with Cerebral Palsy (CP but its clinical course is not well defined.We conducted a retrospective study on children with hemiparetic CP who were referred to Pediatric Neurology Department of Mofid Hospital. The aim of our study was to evaluate the risk factors and prognosis of epilepsy in children with hemiparetic CP.Materials & MethodsWe evaluated 64 children with hemiparetic CP who were referred to Pediatric Neurology Department of Mofid Hospital between 2006 and 2008.According to our protocol, patients were divided into two groups: 34 children in the case group (hemiparetic patients with epilepsy and 30 children in the control group (hemiparetic patients without epilepsy.ResultsPrenatal, perinatal and postnatal events, maternal age at the time of delivery, socioeconomic status of the family, familial history of epilepsy, neuroimaging findings, side of the hemiparesia and age at diagnosis of hemiparesis were not considered as risk factors for epilepsy in hemiparetic children, but microcephaly, severity of hemiparetic CP and mental retardation were significantly associated with an increased risk of epilepsy in children with hemiparetic CP.ConclusionOur study showed that microcephaly, severity of hemiparesis and mental retardation were risk factors for developing epilepsy in children with hemiparetic CP; furthermore, they had negative effects on rehabilitation outcome in these patients.Keyword:Hemiparetic Cerebral Palsy, Epilepsy, Children, Microcephaly, Mental Retardation

  11. RISK FACTORS AND PROGNOSIS OF EPILEPSY IN CHILDREN WITH HEMIPARETIC CEREBRAL PALSY

    Directory of Open Access Journals (Sweden)

    Seyyed Hassan TONEKABONI

    2010-11-01

    Full Text Available AbstractObjectiveEpilepsy is reported in 15-90% of the children with Cerebral Palsy (CP but its clinical course is not well defined.We conducted a retrospective study on children with hemiparetic CP who were referred to Pediatric Neurology Department of Mofid Hospital. The aim of our study was to evaluate the risk factors and prognosis of epilepsy in children with hemiparetic CP.Materials & MethodsWe evaluated 64 children with hemiparetic CP who were referred to Pediatric Neurology Department of Mofid Hospital between 2006 and 2008.According to our protocol, patients were divided into two groups: 34 children in the case group (hemiparetic patients with epilepsy and 30 children in the control group (hemiparetic patients without epilepsy.ResultsPrenatal, perinatal and postnatal events, maternal age at the time of delivery, socioeconomic status of the family, familial history of epilepsy, neuroimaging findings, side of the hemiparesia and age at diagnosis of hemiparesis were not considered as risk factors for epilepsy in hemiparetic children, but microcephaly, severity of hemiparetic CP and mental retardation were significantly associated with an increased risk of epilepsy in children with hemiparetic CP.ConclusionOur study showed that microcephaly, severity of hemiparesis and mental retardation were risk factors for developing epilepsy in children with hemiparetic CP; furthermore, they had negative effects on rehabilitation outcome in these patients.

  12. Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Yi-Fang Han; Jun Zhao; Li-Ye Ma; Jian-Hua Yin; Wen-Jun Chang; Hong-Wei Zhang; Guang-Wen Cao

    2011-01-01

    Primary liver cancer is an important cause of cancer death,and hepatocellular carcinoma (HCC) accounts for 70%-85% of total liver cancer worldwide.Chronic hepatitis B virus (HBV) infection contributes to > 75% of HCC cases.High serum viral load is the most reliable indicator of viral replication in predicting development of HCC.HBV genotype C is closely associated with HCC in cirrhotic patients aged > 50 years,whereas genotype B is associated with development of HCC in non-cirrhotic young patients and postoperative relapse of HCC.Different HBV subgenotypes have distinct patterns of mutations,which are clearly associated with increased risk of HCC.Mutations accumulate during chronic HBV infection and predict occurrence of HCC.Chronic inflammation leads to increased frequency of viral mutation via cellular cytidine deaminase induction.Mutations are negatively selected by host immunity,whereas some immuno-escaped HBV mutants are active in hepatocarcinogenesis.Inflammatory pathways contribute to the inflammation-necrosis-regeneration process,ultimately HCC.Their hallmark molecules can predict malignancy in HBV-infected subjects.Continuing inflammation is involved in hepatocarcinogenesis and closely related to recurrence and metastasis.HBV load,genotype C,viral mutations and expression of inflammatory molecules in HBV-related HCC tissues are significantly associated with poor prognosis.Imbalance between intratumoral CD8+ T cells and regulatory T cells or Th1 and Th2 cytokines in peritumoral tissues can predict prognosis of HBV-related HCC.These factors are important for developing active prevention and surveillance of HBV-infected subjects who are more likely to develop HCC,or for tailoring suitable treatment to improve survival or postpone postoperative recurrence of HCC.

  13. Risk factors for adverse outcome in preterm infants with periventricular hemorrhagic infarction

    NARCIS (Netherlands)

    Roze, Elise; Kerstjens, Jorien M.; Maathuis, Carel G. B.; ter Horst, Hendrik J.; Bos, Arend F.

    2008-01-01

    OBJECTIVE. Our objective was to identify risk factors that were associated with mortality and adverse neurologic outcome at 18 months of age in preterm infants with periventricular hemorrhagic infarction. METHODS. This was a retrospective cohort study of all preterm infants who were <37 weeks' gesta

  14. A Health Care Worker with Ebola Virus Disease and Adverse Prognostic Factors Treated in Sierra Leone.

    Science.gov (United States)

    O'Shea, Matthew K; Clay, Katherine A; Craig, Darren G; Moore, Alastair J; Lewis, Stephen; Espina, Melanie; Praught, Jeff; Horne, Simon; Kao, Raymond; Johnston, Andrew M

    2016-04-01

    We describe the management of a Sierra Leonean health care worker with severe Ebola virus disease complicated by diarrhea, significant electrolyte disturbances, and falciparum malaria coinfection. With additional resources and staffing, high quality care can be provided to patients with Ebola infection and adverse prognostic factors in west Africa. PMID:26903609

  15. Causal Factors Influencing Adversity Quotient of Twelfth Grade and Third-Year Vocational Students

    Science.gov (United States)

    Pangma, Rachapoom; Tayraukham, Sombat; Nuangchalerm, Prasart

    2009-01-01

    Problem statement: The aim of this research was to study the causal factors influencing students' adversity between twelfth grade and third-year vocational students in Sisaket province, Thailand. Six hundred and seventy two of twelfth grade and 376 third-year vocational students were selected by multi-stage random sampling techniques. Approach:…

  16. A Clinical Investigation into the Factors Influencing the Prognosis of Patients with Primary Liver Cancer after Hepatectomy

    Institute of Scientific and Technical Information of China (English)

    Ji Xi-qing; Li Chao-long; Sheng Xing-hua

    2005-01-01

    Objective To explore the factors influencing the prognosis of patients with primary liver cancer(PLC) after hepatectomy on purpose to provide the preventive measures for improving the long-term effect.Methods All of the 189 patients who underwent hepatectomy with PLC from May,1994 to January,1998 were included by reviewing their clinical pathological characteristics and treatments. Totally, 22 factors contributed to the long-term survival rate(SR)and the disease-free SR were analysed . All patients were followed up at least 5 years. Results The 3- and 5-year cumulative SRs in the total group were 63% and 45% respectively. The 3- and 5-year SRs and disease-free SRs in the curative resection (CR) group (n=162) were 67%,47%,and 45% and 26% respectively. It was showed that the way by which a tumor was found, tumor size, portal thrombi, satellite nodule, cirrhosis type, TNM stage, tumor envelope, recurrence and treatment, vascular exclusion and transfusion, differentiation grade and CR were prognostic factors by individual variable analysis. A multivariable analysis showed that CR , tumor size and reoperation were significant factors associated with the prognosis. Conclusion The type of CR and tumor size are determinants influencing the prognosis. Early diagnosis of small carcinoma and CR as soon as possible is essential to improving the prognosis of PLC. Avoiding transfusion and controlling the progress of cirrhosis are expected to improve the disease-free SR.

  17. Epidermal Growth Factor Receptor Inhibitors: A Review of Cutaneous Adverse Events and Management

    OpenAIRE

    Chanprapaph, K.; Vachiramon, V.; Rattanakaemakorn, P.

    2014-01-01

    Epidermal growth factor inhibitors (EGFRI), the first targeted cancer therapy, are currently an essential treatment for many advance-stage epithelial cancers. These agents have the superior ability to target cancers cells and better safety profile compared to conventional chemotherapies. However, cutaneous adverse events are common due to the interference of epidermal growth factor receptor (EGFR) signaling in the skin. Cutaneous toxicities lead to poor compliance, drug cessation, and psychos...

  18. The role of ADHD in academic adversity: disentangling ADHD effects from other personal and contextual factors.

    Science.gov (United States)

    Martin, Andrew J

    2014-12-01

    Students with attention-deficit/hyperactivity disorder (ADHD) experience significant academic difficulties that can lead to numerous negative academic consequences. With a focus on adverse academic outcomes, this study seeks to disentangle variance attributable to ADHD from variance attributable to salient personal and contextual covariates. Responses from 136 students with ADHD and 3,779 non-ADHD peers from 9 high schools were analyzed using logistic regression. Dependent measures included academic failure, grade repetition, school refusal, changing classes and school, school exclusion, and schoolwork noncompletion. Covariates comprised personal (e.g., sociodemographics, personality, prior achievement, specific learning disabilities, motivation) and contextual (e.g., school size, school socioeconomic status, school average achievement) factors. Findings indicated that, after accounting for personal and contextual covariates, ADHD explained significant variance in numerous adversities (schoolwork noncompletion, school suspension, school expulsion, changing schools, grade repetition). Thus, beyond the effects of numerous personal and contextual covariates, ADHD has a distinct presence in students' academic adversity. Also interesting, after accounting for other personal and contextual factors, was academic adversity with which ADHD was not associated. Findings provide direction for educational intervention targeting ADHD and associated factors found to be significant in the study. PMID:24820011

  19. Prognosis factors and characteristics of tumor recurrences in adults treated for a medulloblastoma; Facteurs pronostiques et caracteristiques des rechutes tumorales chez des adultes traites pour un medulloblastome

    Energy Technology Data Exchange (ETDEWEB)

    Chargari, C.; Feuvret, L.; Levy, A.; Lamproglou, I.; Assouline, A.; Lopez, S.; Lang, P.; Simon, J.M.; Mazeron, J.J. [Hopital Pitie-Salpetriere, 75 - Paris (France); Vedrine, L. [Hopital Val-de-Grace, 75 - Paris (France)

    2009-10-15

    The quality of resection is a major prognosis factor. The systematic postoperative MRI allows a precise selection of patients with standard risk medulloblastomas for which the only radiotherapy allows an excellent local control. The radiotherapy stopping and the delay are prognosis factors of neurology recurrence. (N.C.)

  20. Self-immolation and its adverse life-events risk factors: results from an Iranian population

    Directory of Open Access Journals (Sweden)

    Alireza Ahmadi

    2015-01-01

    Full Text Available Abstract: Background: Despite considerable loss of life by deliberate self-burning in low and middle-income countries, few scholars have examined psychiatric factors such as adverse life events that may be related to self-immolation. Methods: This case-control study investigated adverse life-events as risk factors for self-immolation patients admitted to a burn center serving the western region of Iran. Variables inves-tigated included the following adverse life-events: unplanned pregnancy, infertility, homelessness, financial hardship, problems with friends, intimate relationship break-up , school or university failure, anxiety about school/university performance, problems at work, personal history of suicide attempts, family history of suicide attempts, individual history of mental disorders, and malignant disease. Results: Financial hardship (OR=3.35, 95% CI=1.19-9.90, intimate relationship break-up (OR=5.45, 95% CI=1.20-11.99, and personal history of suicide attempts (OR=7.00, 95% CI=1.38-35.48 were associated with increased risk of self-immolation. Conclusions: This study suggests that financial hardship, intimate relationship break-ups, and personal history of suicide attempts are risk factors for self-immolation. Other variables studied did not play a role as individually protective or risk factors for self-immolation. Further study is needed to substantiate findings of this study and direct research toward tailoring culturally sensitive, empirically-supported interventions for prevention of self-immolation.

  1. Circulating angiogenic factors and urinary prolactin as predictors of adverse outcomes in women with preeclampsia.

    Science.gov (United States)

    Leaños-Miranda, Alfredo; Campos-Galicia, Inova; Ramírez-Valenzuela, Karla Leticia; Chinolla-Arellano, Zarela Lizbeth; Isordia-Salas, Irma

    2013-05-01

    Preeclampsia is characterized by an imbalance in angiogenic factors. Urinary prolactin (PRL) levels and its antiangiogenic PRL fragments have been associated with disease severity. In this study, we assessed whether these biomarkers are associated with an increased risk of adverse maternal and perinatal outcomes in preeclamptic women. We studied 501 women with preeclampsia attended at a tertiary care hospital. Serum concentrations of soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and soluble endoglin (sEng), as well as urinary PRL levels, were measured by enzymed-linked immunosorbent assay. Antiangiogenic PRL fragments were determined by immunoblotting. The risk for any adverse maternal outcome and for having a small-for-gestational-age infant was higher among women with sFlt-1/PlGF ratios, sEng, and urinary PRL level values in the highest quartile (odds ratios ≥ 2.7), compared with the lowest quartile. Both urinary PRL levels and the presence of antiangiogenic PRL fragments were more closely associated with the risk of specific adverse maternal outcomes (placental abruption, hepatic hematoma or rupture, acute renal failure, pulmonary edema, maternal death, and need for endotracheal intubation, positive inotropic drug support, and hemodialysis; odds ratios ≥ 5.7 and ≥ 4.7, respectively) than either sFlt-1/PlGF ratio or sEng alone. We concluded that in preeclamptic women at the time of initial evaluation, sFlt-1/PlGF ratio and sEng are associated with increased risk of combined adverse maternal outcomes. However, urinary PRL concentrations and its antiangiogenic fragments appear to be better predictors of an adverse maternal outcome and may be useful for risk stratification in preeclampsia. PMID:23460287

  2. Analysis of Prognosis and Prognostic Factors of Cervical Adenocarcinoma and Adenosqumous Carcinoma of the Cervix

    Institute of Scientific and Technical Information of China (English)

    Guangwen Yuan; Lingying Wu; Xiaoguang Li; Manni Huang

    2009-01-01

    OBJECTIVE To analyze clinical characteristics and treatment methods of the patients with adenocarcinoma of the uterine cervix (AUC) and adenosquamous carcinoma of the cervix (ASCC). To compare the survival time of the patients in 2 groups and analyze the prognostic factors.METHODS Clinical data of both 123 patients with AUC and 32 patients with ASCC treated at the Cancer Hospital, Chinese Academy of Medical Science (CAMS) & Peking Union Medical College (PUMC), were retrospectively analyzed.RESULTS The median age of the AUC patients was 50 years, and that of the ASCC patients was 44, P = 0.019. Poorly-differentiated (grade 3) cases accounted for 59.5% of the total ASCC patients,while only 32.5% of the AUC patients were in grade 3, P = 0.002.In 123 AUC patients, relapse or failure of the treatment occurred in 63 of the patients (51.2%), and the median relapse time was 6 months (0-59 months). In 32 ASCC patients, relapse or failure of the treatment occurred in 8 of these patients (51.2%), with a median relapse time of 4.5 months (0-52 months). The overall 5-year survival rate of the AUC patients was 49.8%, which was significantly lower than that of the ASCC patients (74.1%), P =0.015. The 5-year survival rates of the ASCC patients in Stage Ⅰ-Ⅲ were higher than that of the AUC patients with the same stages.However, statistical significant difference could only be found among the patients in Stage Ⅱ, P = 0.006. The 5-year survival rates of the ASCC patients with various differential grade were higher than those of the AUC patients with the same differential grade,but statistical significant difference could only be found among the patients in the two groups with moderately differentiation,P = 0.039. It was found by Cox regression analysis that only clinical stage (P < 0.001) and histological type (P = 0.046) were the independent prognostic factors.CONCLUSION Clinical stage and histological type were the independent prognostic factors of the AUC and ASCC patients

  3. Coagulation factors and recurrence of ischemic and bleeding adverse events in patients with acute coronary syndromes.

    Science.gov (United States)

    Campo, Gianluca; Pavasini, Rita; Pollina, Alberto; Tebaldi, Matteo; Ferrari, Roberto

    2013-08-01

    In the last years, management and prognosis of patients with acute coronary syndromes (ACS) are significantly improved. Nowadays antithrombotic (antiplatelet plus anticoagulant drugs) therapy represents the main treatment of ACS patients. Anticoagulant drugs are particularly helpful in the acute phase of ACS, whereas in the chronic phase are maintained only in selected cases. Many studies demonstrate that exists a significant variability in the coagulation factor levels between patients affected by ACS. This variation on coagulation factors levels is due to environmental (smoking, inflammation, sex, oral contraceptive, triglycerides, diabetes mellitus) and genetic determinants. Particularly several gene polymorphisms have been selected and clearly associated with significant variations in the coagulation factors values. The heightened levels of tissue factor, factor VII and fibrinogen are related with a "hypercoagulable status" and with a higher occurrence of ischemic complications after ACS and/or PCI. On the contrary, less data are available regarding the relationship between coagulation factors levels (or their gene polymorphisms) and bleeding complications. Recently, new anticoagulant drugs have been developed. They show less side effects and a better tolerability and, probably, their selected use in patients with a "hypercoagulable status" may improve the clinical outcome after ACS. In this review we analyze the current available data and we discuss how this finding may be useful for planning future studies to optimize the treatment of ACS patients. PMID:23827698

  4. Transarterial Chemoembolization for Hepatocellular Carcinomas with Central Bile Duct Invasion: Safety, Prognosis, and Predictive Factors

    International Nuclear Information System (INIS)

    PurposeTo assess the safety and effectiveness of transarterial chemoembolization (TACE) of patients who have hepatocellular carcinomas (HCCs) with central bile duct invasion.Materials and MethodsThe institutional review board approved this retrospective study and waived informed consent. Fifty-three patients, initially treated with TACE for HCCs with central bile duct invasion from January 1999 to September 2012, were included. Clinical, laboratory, and survival data were reviewed. Complications and hospitalization length were evaluated using the χ2 test, Fisher’s exact test, and logistic regression analysis. Survival was analyzed using the Kaplan–Meier method with log-rank test and Cox proportional hazard model.ResultsSeven patients experienced TACE-related major complications (severe post-embolization syndrome in 3, non-fatal sepsis in 3, and secondary bacterial peritonitis in 1). The overall major complication rate was 13.2 %, but there were no permanent adverse sequelae or deaths within 30 days. Serum total bilirubin ≥3.0 mg/dL was the only significant risk factor for long hospitalization [hazard ratio (HR) = 4.341, p = .022]. The median survival was 12.2 months. Extrahepatic metastasis (HR = 6.145, p < .001), international normalized ratio (PT-INR) ≥1.20 (HR = 4.564, p < .001), vascular invasion (HR = 3.484, p = .001), and intermediate tumor enhancement (HR = 2.417, p = .019) were significantly associated with shorter survival.ConclusionTACE can be a safe and effective treatment for patients who have HCCs with central bile duct invasion. In particular, long-term survival can be expected if patients have strongly enhancing tumors without poor prognostic factors such as extrahepatic metastasis, PT-INR prolongation, and vascular invasion

  5. Transarterial Chemoembolization for Hepatocellular Carcinomas with Central Bile Duct Invasion: Safety, Prognosis, and Predictive Factors

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jin Woo; Chung, Jin Wook, E-mail: chungjw@snu.ac.kr [Seoul National University Hospital, Department of Radiology (Korea, Republic of); Cho, Yun Ku [VHS Medical Center, Department of Radiology (Korea, Republic of); Kim, Yoon Jun; Yoon, Jung-Hwan [Seoul National University Hospital, Department of Internal Medicine (Korea, Republic of); Kim, Hyo-Cheol; Jae, Hwan Jun [Seoul National University Hospital, Department of Radiology (Korea, Republic of)

    2015-08-15

    PurposeTo assess the safety and effectiveness of transarterial chemoembolization (TACE) of patients who have hepatocellular carcinomas (HCCs) with central bile duct invasion.Materials and MethodsThe institutional review board approved this retrospective study and waived informed consent. Fifty-three patients, initially treated with TACE for HCCs with central bile duct invasion from January 1999 to September 2012, were included. Clinical, laboratory, and survival data were reviewed. Complications and hospitalization length were evaluated using the χ{sup 2} test, Fisher’s exact test, and logistic regression analysis. Survival was analyzed using the Kaplan–Meier method with log-rank test and Cox proportional hazard model.ResultsSeven patients experienced TACE-related major complications (severe post-embolization syndrome in 3, non-fatal sepsis in 3, and secondary bacterial peritonitis in 1). The overall major complication rate was 13.2 %, but there were no permanent adverse sequelae or deaths within 30 days. Serum total bilirubin ≥3.0 mg/dL was the only significant risk factor for long hospitalization [hazard ratio (HR) = 4.341, p = .022]. The median survival was 12.2 months. Extrahepatic metastasis (HR = 6.145, p < .001), international normalized ratio (PT-INR) ≥1.20 (HR = 4.564, p < .001), vascular invasion (HR = 3.484, p = .001), and intermediate tumor enhancement (HR = 2.417, p = .019) were significantly associated with shorter survival.ConclusionTACE can be a safe and effective treatment for patients who have HCCs with central bile duct invasion. In particular, long-term survival can be expected if patients have strongly enhancing tumors without poor prognostic factors such as extrahepatic metastasis, PT-INR prolongation, and vascular invasion.

  6. Predisposing factors, diagnosis, treatment and prognosis of cerebral venous thrombosis during pregnancy and postpartum: a case-control study

    Institute of Scientific and Technical Information of China (English)

    GAO Hui; YANG Bao-jun; JIN Li-ping; JIA Xiao-fang

    2011-01-01

    Background Previous investigations have demonstrated a relatively low incidence of stroke among young women,though both pregnancy and delivery can substantially increase the risk.Cerebral venous thrombosis may manifest different characteristics during pregnancy and postpartum as a result of their specific physiological statuses.This study aimed to identify the clinical manifestations,diagnosis,treatment,and prognosis of cerebral venous thrombosis during pregnancy and postpartum.Methods We conducted a retrospective analysis of 22 patients with cerebral venous thrombosis who were assigned to either group A (during pregnancy) or group B (during postpartum).The relevant risk factors,initiation and development of the disease,clinical presentations,diagnosis,treatment,and prognosis were compared between the two stages.Results Cerebral venous thrombosis occurred during both pregnancy and postpartum,but was more common postpartum.Patients in group A had a longer hospitalization period than those in group B.Confirmed predisposing factors in 85.7% of patients of group A were dehydration,infection,and underlying cerebrovascular disorders.No obvious predisposing factors were identified in group B.The most frequent symptom was headache,with epileptic seizures,hemiparalysis and aphasia being less frequent symptoms.Focal neurological symptoms (P=0.022) and cerebral infarction (P=0.014) occurred more frequently in group A than in group B.Anticoagulation therapy proved to be safe for cerebral venous thrombosis patients during puerperium,regardless of parenchymal hemorrhage.However,more attention should be paid to spontaneous in-site placental hemorrhage in pregnant patients.Both groups had similar prognoses (P=1.000),with 36.3% patients suffering from consequential dysfunction or recurrent intracranial hypertension.Delayed diagnosis was associated with a poorer prognosis.Conclusions Cerebral venous thrombosis manifests different clinical characteristics during pregnancy and

  7. Liver dysfunction assessed by model for end-stage liver disease excluding INR (MELD-XI scoring system predicts adverse prognosis in heart failure.

    Directory of Open Access Journals (Sweden)

    Satoshi Abe

    Full Text Available AIMS: Liver dysfunction due to heart failure (HF is often referred to as cardiac or congestive hepatopathy. The composite Model for End-Stage Liver Disease excluding INR (MELD-XI is a robust scoring system of liver function, and a high score is associated with poor prognosis in advanced HF patients with a heart transplantation and/or ventricular assist device. However, the impact of MELD-XI on the prognosis of HF patients in general remains unclear. METHODS AND RESULTS: We retrospectively analyzed 562 patients who were admitted to our hospital for the treatment of decompensated HF. A MELD-XI score was graded, and patients were divided into two groups based on the median value of MELD-XI score: Group L (MELD-XI <10, n = 289 and Group H (MELD-XI ≥10, n = 273. We compared all-cause mortality and echocardiographic findings between the two groups. In the follow-up period (mean 471 days, 104 deaths (62 cardiac deaths and 42 non-cardiac deaths were observed. The event (cardiac death, non-cardiac death, all-cause death-free rate was significantly higher in group L than in group H (logrank P<0.05, respectively. In the Cox proportional hazard analysis, a high MELD-XI score was found to be an independent predictor of cardiac deaths and all-cause mortality in HF patients. Regarding echocardiographic parameters, right atrial and ventricular areas, inferior vena cava diameter, and systolic pulmonary artery pressure were higher in group H than in group L (P<0.05, respectively. CONCLUSIONS: The MELD-XI scoring system, a marker of liver function, can identify high-risk patients with right heart volume overload, higher pulmonary arterial pressure and multiple organ failure associated with HF.

  8. Causal Factors Influencing Adversity Quotient of Twelfth Grade and Third-Year Vocational Students

    OpenAIRE

    Rachapoom Pangma; Sombat Tayraukham; Prasart Nuangchalerm

    2009-01-01

    Problem statement: The aim of this research was to study the causal factors influencing students adversity between twelfth grade and third-year vocational students in Sisaket province, Thailand. Six hundred and seventy two of twelfth grade and 376 third-year vocational students were selected by multi-stage random sampling techniques. Approach: The instruments used for collecting data were: A scale on self-esteem, a scale on dominance, a scale on self-confidence, a scale on sense of personal f...

  9. Cytosolic phospholipase A2-alpha expression in breast cancer is associated with EGFR expression and correlates with an adverse prognosis in luminal tumours.

    LENUS (Irish Health Repository)

    Caiazza, F

    2012-02-01

    BACKGROUND: The eicosanoid signalling pathway promotes the progression of malignancies through the production of proliferative prostaglandins (PGs). Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) activity provides the substrate for cyclooxygenase-dependent PG release, and we have previously found that cPLA(2)alpha expression correlated with EGFR\\/HER2 over-expression in a small number of breast cancer cell lines. METHODS: The importance of differential cPLA(2)alpha activity in clinical breast cancer was established by relating the expression of cPLA(2)alpha in tissue samples from breast cancer patients, and two microarray-based gene expression datasets to different clinicopathological and therapeutic parameters. RESULTS: High cPLA(2)alpha mRNA expression correlated with clinical parameters of poor prognosis, which are characteristic of highly invasive tumours of the HER2-positive and basal-like subtype, including low oestrogen receptor expression and high EGFR expression. High cPLA(2)alpha expression decreased overall survival in patients with luminal cancers, and correlated with a reduced effect of tamoxifen treatment. The cPLA(2)alpha expression was an independent predictive parameter of poor response to endocrine therapy in the first 5 years of follow-up. CONCLUSION: This study shows a role of cPLA(2)alpha in luminal breast cancer progression, in which the enzyme could represent a novel therapeutic target and a predictive marker.

  10. Evaluation of Peritonitis Incidence, Etiology, Associated Factors and Prognosis of Continuous Ambulatory Peritoneal Dialysis Patients

    Directory of Open Access Journals (Sweden)

    Nefise ÖZBALCI

    2013-05-01

    Full Text Available OBJECTIVE: Peritonitis is the most important complication of peritoneal dialysis (PD. We evaluated the incidence of peritonitis, active microorganisms and their susceptibility profile and determine prognosis. MATERIAL and METHODS: One hundred fifty three PD patients were evaluated for aetiology, drug usage, accompanying disease, type, duration and personal preference for PD, care-giver, protein catabolic rate (PCR, residual urine volume, ultrafiltration volume, type of peritoneal membrane transport and baseline laboratory values. RESULTS: The incidence of peritonitis was 0,284 attack/patient/year. The most common organisms were coagulase negative staphylococci (18.3% followed by S. aureus (14.8% and gram-negative bacillus (13.1%. Peritonitis was more common in elderly, those with longer PD duration, low residual urine volume, patients with low PCR and hepatitis C. However, patients using erythropoietin and automated PD had low incidence of peritonitis compared to others. Mortality rate was higher in gram-negative and fungal peritonitis and prognosis was worse in gramnegative peritonitis CONCLUSION: Peritonitis incidence and aetiology were compatible with literature. One must be careful to protect residual renal function (RRF as peritonitis incidence was significantly reduced in patients with RRF. PCR values were significantly lower in peritonitis. Adequate protein intake and nutritional support may be important in this respect.

  11. Concurrent radiotherapy and intrathecal methotrexate for treating leptomeningeal metastasis from solid tumors with adverse prognostic factors: A prospective and single-arm study.

    Science.gov (United States)

    Pan, Zhenyu; Yang, Guozi; He, Hua; Zhao, Gang; Yuan, Tingting; Li, Yu; Shi, Weiyan; Gao, Pengxiang; Dong, Lihua; Li, Yunqian

    2016-10-15

    The prognosis of leptomeningeal metastasis (LM) from solid tumors is extremely poor, especially for patients with adverse prognostic factors. In this phase II clinical trial, we evaluated the efficacy and safety of intrathecal chemotherapy (IC) combined with concomitant involved-field radiotherapy (IF-RT) for treating LM from solid tumors with adverse prognostic factors. Fifty-nine patients with LM from various solid tumors were enrolled between May 2010 and December 2014. Concurrent therapy consisted of concomitant IC (methotrexate 12.5-15 mg and dexamethasone 5 mg, weekly) and IF-RT (whole brain and/or spinal canal RT, 40 Gy/20f). For patients with low Karnofsky performance status (KPS) score and radiotherapy intolerance, induction IC (1-3 times) was given before concurrent therapy. Thirty-eight patients (64.4%) received subsequent treatments. All patients were followed up at least 6 months after LM diagnosis or until death. Primary endpoint evaluated was clinical response rate. Secondary endpoints were overall survival (OS) and safety. The pathological types included lung cancer (n = 42), breast cancer (n = 11) and others (n = 6). Median KPS score was 40 (range 20-70). Fifty-one patients (86.4%) completed concurrent therapy. The overall response rate was 86.4% (51/59). OS ranged from 0.4 to 36.7 months (median 6.5 months), and 1-year-survival rate was 21.3%. Treatment-related adverse events mainly included acute meningitis, chronic-delayed encephalopathy, radiculitis, myelosuppression and mucositis. Twelve patients (20.3%) had grade III-V toxic reactions. We concluded that IC combined with concomitant IF-RT, with significant efficacy and acceptable toxicity, may be an optimal therapeutic option for treatment of LM from solid tumors with adverse prognostic factors. LM, in which cancer cells spread to membranes enveloping the brain and spinal cord, is a devastating complication of solid cancers. Existing LM therapies center on IC. In this prospective

  12. Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab

    Directory of Open Access Journals (Sweden)

    Emilio Besada

    2016-01-01

    Full Text Available Background. 29 GPA patients from the Northern Norway vasculitis disease registry received rituximab (RTX induction and maintenance. 24% and 31% had, respectively, severe and chronic infections while 45% had hypogammaglobulinemia and 28% discontinued RTX due to hypogammaglobulinemia. The aim of the study was to examine how known predictors and adverse events interacted with adverse events using structural statistical methods. Methods. Five predictors (age, cyclophosphamide, total Ig and CD4/CD8 ratio prior RTX, and type of RTX maintenance regimen and 4 adverse events (severe and chronic infections, hypogammaglobulinemia, and RTX discontinuation were modeled in principal component and redundancy analyses. Results. The 5 predictors explained 51% of the variance of the GPA cohort. Models including cyclophosphamide exposure and total Ig level predicted best adverse events. However total Ig level has low R squared. The 2 best combinations of adverse events explained 13% of the variance of the predictors and adverse events. Only chronic infections were associated with combination of all adverse events (P=0.014. Hypogammaglobulinemia did not seem associated with the other adverse events. Conclusions. Traditional risk factors for infections and hypogammaglobulinemia seemed to poorly predict adverse events in our GPA cohort.

  13. Vascular endothelial growth factor A and vascular endothelial growth factor receptor 2 expression in non-small cell lung cancer patients: relation to prognosis

    DEFF Research Database (Denmark)

    Bonnesen, Barbara; Pappot, Helle; Holmstav, Julie;

    2009-01-01

    elements in neoplastic cells and their microenvironment have recently been and are continuously developed including drugs inhibiting the angiogenic system. Angiogenic factor vascular endothelial growth factor (VEGF) and its receptor vascular endothelial growth factor receptor 2 (VEGFR2) seem to play key...... stained on whole tumour slides. Kaplan-Meier survival curves were generated to evaluate the significance of immunohistochemical VEGF-A and VEGFR2 expression for the prognosis. RESULTS: VEGF-A and VEGFR2 expression was observed in the majority of NSCLC patients. VEGF-A expression showed a correlation to...

  14. ACTUAL WAYS FOR OVERCOMING THE FACTORS ADVERSELY AFFECTING THE CHILDREN AND ADOLESCENTS’ HEALTH IN EDUCATIONAL INSTITUTIONS

    Directory of Open Access Journals (Sweden)

    N. N. Malyarchuk

    2014-01-01

    Full Text Available The paper analyzes a widely discussed problem of the negative health dynamics of the growing generation, and points out the necessity of complex consideration of all the factors adversely affecting children’s health. The special emphasis is on the fallowing harmful factors: intensification of training process; discrepancy between the applied training methods and techniques on the one side, and children’s age, sex and functional specifics and capabilities on the other side; shortcomings in organizing children’s physical activities; limitations of the expositive illustrative methods for developing the healthy lifestyle habits. The other group of factors is related to the teaching style and professional characteristics of the teachers. They include the common practice of «stress» tactics; incompetence in health saving technologies; personal indisposition and psychological drawbacks. The situation is exacerbated by the absence of psychologists and pediatricians in educational institutions. The multilevel approach to solving the problems of students’ health preservation and promotion involves the elicitation of objective, subjective, inschool and out-of-school health determining factors. The paper denotes the actual ways of children’s health preservation at the level of related ministries, departments, and educational institutions.

  15. Antiepileptic Drug-Related Adverse Reactions and Factors Influencing These Reactions

    Directory of Open Access Journals (Sweden)

    Parvaneh KARIMZADEH

    2013-08-01

    Full Text Available How to Cite This Article: Karimzadeh P, Bakrani V. Antiepileptic Drug-Related Adverse Reactions And Factors Influencing These Reactions. Iran J Child Neurol. 2013 Summer; 7(3:23-27. ObjectiveAccording to the basic role of drug side effects in selection ofan appropriate drug, patient compliance and the quality of life inepileptic patients, and forasmuch as new dugs with unknown side effect have been produced and introduced, necessity of this research and similar studies is explained. This study was conducted to evaluate the incidence and clinical characteristics of anti epileptic drug (AED related adverse reactions in children treated with AEDs.Material & MethodsIn this descriptive study, children less than 14 years old with AEDside effects referred to the Children’s Medical Center and MofidChilderen’s Hospital (Tehran, Iran were evaluated during 2010-2012.The informations were: sex, age, incriminating drug, type of drug side effect, incubation period, history of drug usage, and patient and family allergy history. Exclusive criterions were age more than 14 years old and reactions due to reasons other than AEDs (Food, bite, non-AEDs, etc..ResultsA total of 70 patients with AED reaction were enrolled in thisstudy. They included 26 (37% females and 44 (63 % males. The maximum rate of incidence was seen at age less than 5 years old. All the patients had cutaneous eruptions that the most common cutaneous drug eruption was maculopapular rash. The incidence of systemic and laboratory adverse events was less than similar studies. The most common culprit was phenobarbital (70% and the least common was lamotrigine (1.4%.ConclusionIn this study, we found higher rates of drug rash in patients treated with aromatic AEDs and lower rates with non-aromatic AEDs. Various endogenous and environmental factors may influence the propensity to develop these reactions. Refrences1. Blume WT, Lu¨ders HO, Mizrahi E, et al. Glossary of descriptive terminology for

  16. Correlations of hypoxia-inducible factor-1α/hypoxia-inducible factor -2α expression with angiogenesis factors expression and prognosis in non-small cell lung cancer

    Institute of Scientific and Technical Information of China (English)

    WU Xian-hua; QIAN Cheng; YUAN Kai

    2011-01-01

    Background Hypoxia-inducible factor (HIF) may play an important role in the process of tumorigenesis as well as tumor progression. The aim of this study was to compare the expression between HIF-1α and HIF-2α in tumor angiogenesis and the overall impact on patient prognosis in human non-small cell lung cancer (NSCLC).Methods In the current work we compared the immunohistochemical expression of HIF-1α and HIF-2α in surgical specimens of 140 patients with NSCLC in a tissue microarray study. Relationships between HIF-α expression and clinicopathological or angiogenic factors, including prognosis, were analyzed.Results High HIF-1α and HIF-2α expression was noted in 49/140 (35.0%) and in 64/140 (45.7%) of the cases,respectively. There was no direct correlation between HIF-1α and HIF-2α expression. Patients with advanced stage tumors had frequent high expression of HIF-2α (P=0.007), and we also found a significant correlation between HIF-2αand T or N stage (P=0.030 and 0.043, respectively). HIF-1α showed a marginal association with T stage (P=0.084),which showed a higher expression in early stage tumors. A significant correlation (P=0.045) was noticed between HIF-1αand vascular endothelial growth factor (VEGF) expression while the expression levels of thymidine phosphorylase (TP),cyclooxygenase (COX)-2 and microvessel density (MVD) were significantly higher in high HIF-2α tumors (P=0.020, 0.004,and 0.046, respectively). In addition, univariate analysis of overall survival demonstrated that HIF-2α expression, but not HIF-1α, was related to poor outcome (P=0.001) and it retained significant in multivariate analysis (P=0.036).Conclusions Taken together, we conclude that HIF-1α and HIF-2α may differentially regulate the major angiogenic factors in different stages of the tumor process in NSCLC. HIF-2α may play a dominant role in tumor angiogenesis and appears to be of obvious value as a significant prognostic factor in NSCLC.

  17. SOXs in human prostate cancer: implication as progression and prognosis factors

    International Nuclear Information System (INIS)

    SOX genes play an important role in a number of developmental processes. Potential roles of SOXs have been demonstrated in various neoplastic tissues as tumor suppressors or promoters depending on tumor status and types. The aim of this study was to investigate the involvement of SOXs in the progression and prognosis of human prostate cancer (PCa). The gene expression changes of SOXs in human PCa tissues compared with non-cancerous prostate tissues was detected using gene expression microarray, and confirmed by real-time quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) analysis and immunohositochemistry. The roles of these genes in castration resistance were investigated in LNCaP xenograft model of PCa. The microarray analysis identified three genes (SOX7, SOX9 and SOX10) of SOX family that were significantly dis-regulated in common among four PCa specimens. Consistent with the results of the microarray, differential mRNA and protein levels of three selected genes were found in PCa tissues by QRT-PCR analysis and immunohistochemistry. Additionally, we found that the immunohistochemical staining scores of SOX7 in PCa tissues with higher serum PSA level (P = 0.02) and metastasis (P = 0.03) were significantly lower than those with lower serum PSA level and without metastasis; the increased SOX9 protein expression was frequently found in PCa tissues with higher Gleason score (P = 0.02) and higher clinical stage (P < 0.0001); the down-regulation of SOX10 tend to be found in PCa tissues with higher serum PSA levels (P = 0.03) and advanced pathological stage (P = 0.01). Moreover, both univariate and multivariate analyses showed that the down-regulation of SOX7 and the up-regulation of SOX9 were independent predictors of shorter biochemical recurrence-free survival. Furthermore, we discovered that SOX7 was significantly down-regulated and SOX9 was significantly up-regulated during the progression to castration resistance. Our data offer the convince

  18. Factors Associated with Anti-Tuberculosis Medication Adverse Effects: A Case-Control Study in Lima, Peru

    OpenAIRE

    Kocfa Chung-Delgado; Alejandro Revilla-Montag; Sonia Guillen-Bravo; Eduardo VelezSegovia; Andrea Soria-Montoya; Alexandra Nun˜ ez-Garbin; Wilmer Silva-Caso; Antonio Bernabe-Ortiz

    2011-01-01

    Background: Long-term exposure to anti-tuberculosis medication increases risk of adverse drug reactions and toxicity. The objective of this investigation was to determine factors associated with anti-tuberculosis adverse drug reactions in Lima, Peru, with special emphasis on MDR-TB medication, HIV infection, diabetes, age and tobacco use. Methodology and Results: A case-control study was performed using information from Peruvian TB Programme. A case was defined as having reported an anti-TB a...

  19. Impact of Serum Vascular Endothelial Growth Factor on Prognosis in Patients with Unresectable Hepatocellular Carcinoma after Transarterial Chemoembolization

    Institute of Scientific and Technical Information of China (English)

    Jian-hai Guo; Xu Zhu; Xiao-ting Li; Ren-jie Yang

    2012-01-01

    Objective:To investigate the expression level of serum vascular endothelial growth factor (VEGF) in patients with unresectable hepatocellular carcinoma (HCC) and its relationship with the clinicopathological characteristics,and to assess the impact of serum VEGF as a predictive factor for HCC prognosis during transarterial chemoembolization (TACE) treatments.Methods:Serum VEGF levels were measured using enzyme-linked immunosorbent assay (ELISA) in 60 random patients who underwent TACE or transarterial infusion (TAI) for unresectable HCC between May and September 2008 and 12 healthy volunteers were also involved in this study to serve as control.All patients' clinicopathological features were retrospectively analyzed.Serum VEGF levels were correlated with clinicopathological features of the HCC patients.The patients' survival rates were analyzed with Kaplan-Meier survival curves and compared by the log-rank test.The prognostic significance of serum VEGF levels and factors related to survival rate were evaluated by univariate and multivariate analysis.Results:The median serum VEGF level in the HCC patients was 285 pg/ml (range 14-1,207 pg/ml),significantly higher than that of healthy controls (P=0.021).The serum VEGF levels were significantly correlated with platelet counts (r=0.396,P=0.002) but not other clinicopathological features.Patients with serum VEGF level >285 pg/ml had worse overall survival compared with those with serum VEGF level <285 pg/ml (P=0.002).By multivariate analysis,the serum VEGF level was a significant prognostic factor.Conclusion:High serum VEGF levels may predict poor prognosis of HCC after TACE.This study highlights the importance of tumor biomarker as a prognostic predictor in TACE therapy for HCC,which has an intrinsic problem of unavailability of histopathological prognostic features.

  20. Correlation of Clinical and Dosimetric Factors With Adverse Pulmonary Outcomes in Children After Lung Irradiation

    International Nuclear Information System (INIS)

    Purpose: To identify the incidence and the risk factors for pulmonary toxicity in children treated for cancer with contemporary lung irradiation. Methods and Materials: We analyzed clinical features, radiographic findings, pulmonary function tests, and dosimetric parameters of children receiving irradiation to the lung fields over a 10-year period. Results: We identified 109 patients (75 male patients). The median age at irradiation was 13.8 years (range, 0.04-20.9 years). The median follow-up period was 3.4 years. The median prescribed radiation dose was 21 Gy (range, 0.4-64.8 Gy). Pulmonary toxic chemotherapy included bleomycin in 58.7% of patients and cyclophosphamide in 83.5%. The following pulmonary outcomes were identified and the 5-year cumulative incidence after irradiation was determined: pneumonitis, 6%; chronic cough, 10%; pneumonia, 35%; dyspnea, 11%; supplemental oxygen requirement, 2%; radiographic interstitial lung disease, 40%; and chest wall deformity, 12%. One patient died of progressive respiratory failure. Post-irradiation pulmonary function tests available from 44 patients showed evidence of obstructive lung disease (25%), restrictive disease (11%), hyperinflation (32%), and abnormal diffusion capacity (12%). Thoracic surgery, bleomycin, age, mean lung irradiation dose (MLD), maximum lung dose, prescribed dose, and dosimetric parameters between V22 (volume of lung exposed to a radiation dose ≥22 Gy) and V30 (volume of lung exposed to a radiation dose ≥30 Gy) were significant for the development of adverse pulmonary outcomes on univariate analysis. MLD, maximum lung dose, and Vdose (percentage of volume of lung receiving the threshold dose or greater) were highly correlated. On multivariate analysis, MLD was the sole significant predictor of adverse pulmonary outcome (P=.01). Conclusions: Significant pulmonary dysfunction occurs in children receiving lung irradiation by contemporary techniques. MLD rather than prescribed dose should be used

  1. Correlation of Clinical and Dosimetric Factors With Adverse Pulmonary Outcomes in Children After Lung Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Venkatramani, Rajkumar, E-mail: rvenkatramani@chla.usc.edu [Division of Hematology/Oncology, Children' s Hospital Los Angeles, Los Angeles, California (United States); Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California (United States); Kamath, Sunil [Department of Pulmonology, Children' s Hospital Los Angeles, Los Angeles, California (United States); Wong, Kenneth [Division of Hematology/Oncology, Children' s Hospital Los Angeles, Los Angeles, California (United States); Olch, Arthur J. [Division of Hematology/Oncology, Children' s Hospital Los Angeles, Los Angeles, California (United States); Department of Radiation Oncology, University of Southern California, Los Angeles, California (United States); Malvar, Jemily [Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California (United States); Sposto, Richard [Division of Hematology/Oncology, Children' s Hospital Los Angeles, Los Angeles, California (United States); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California (United States); Goodarzian, Fariba [Department of Radiology, Children' s Hospital Los Angeles, Los Angeles, California (United States); Freyer, David R. [Division of Hematology/Oncology, Children' s Hospital Los Angeles, Los Angeles, California (United States); Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California (United States); Keens, Thomas G. [Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California (United States); Department of Pulmonology, Children' s Hospital Los Angeles, Los Angeles, California (United States); and others

    2013-08-01

    Purpose: To identify the incidence and the risk factors for pulmonary toxicity in children treated for cancer with contemporary lung irradiation. Methods and Materials: We analyzed clinical features, radiographic findings, pulmonary function tests, and dosimetric parameters of children receiving irradiation to the lung fields over a 10-year period. Results: We identified 109 patients (75 male patients). The median age at irradiation was 13.8 years (range, 0.04-20.9 years). The median follow-up period was 3.4 years. The median prescribed radiation dose was 21 Gy (range, 0.4-64.8 Gy). Pulmonary toxic chemotherapy included bleomycin in 58.7% of patients and cyclophosphamide in 83.5%. The following pulmonary outcomes were identified and the 5-year cumulative incidence after irradiation was determined: pneumonitis, 6%; chronic cough, 10%; pneumonia, 35%; dyspnea, 11%; supplemental oxygen requirement, 2%; radiographic interstitial lung disease, 40%; and chest wall deformity, 12%. One patient died of progressive respiratory failure. Post-irradiation pulmonary function tests available from 44 patients showed evidence of obstructive lung disease (25%), restrictive disease (11%), hyperinflation (32%), and abnormal diffusion capacity (12%). Thoracic surgery, bleomycin, age, mean lung irradiation dose (MLD), maximum lung dose, prescribed dose, and dosimetric parameters between V{sub 22} (volume of lung exposed to a radiation dose ≥22 Gy) and V{sub 30} (volume of lung exposed to a radiation dose ≥30 Gy) were significant for the development of adverse pulmonary outcomes on univariate analysis. MLD, maximum lung dose, and V{sub dose} (percentage of volume of lung receiving the threshold dose or greater) were highly correlated. On multivariate analysis, MLD was the sole significant predictor of adverse pulmonary outcome (P=.01). Conclusions: Significant pulmonary dysfunction occurs in children receiving lung irradiation by contemporary techniques. MLD rather than prescribed

  2. Oxygen desaturation in 6-min walk test is a risk factor for adverse outcomes in COPD.

    Science.gov (United States)

    Waatevik, Marie; Johannessen, Ane; Gomez Real, Francisco; Aanerud, Marianne; Hardie, Jon Andrew; Bakke, Per Sigvald; Lind Eagan, Tomas Mikal

    2016-07-01

    The 6-min walk test (6MWT) is an exercise test that measures functional status in chronic obstructive pulmonary disease (COPD) patients and provides information on oxygen desaturation. We investigated oxygen desaturation during 6MWT as a risk factor for important COPD outcomes: mortality, frequency of exacerbations, decline in lung function and decline in lean body mass.433 COPD patients were included in the Bergen COPD Cohort Study 2006-2009, and followed-up for 3 years. Patients were characterised using spirometry, bioelectrical impedance measurements, Charlson comorbidity score, exacerbation history, smoking and arterial blood gases. 370 patients completed the 6MWT at the baseline of the study. Information on all-cause mortality was collected in 2011.Patients who experienced oxygen desaturation during the 6MWT had an approximately twofold increased risk of death (hazard ratio 2.4, 95% CI 1.2-5.1), a 50% increased risk for experiencing later COPD exacerbations (incidence rate ratio 1.6, 95% CI 1.1-2.2), double the yearly rate of decline in both forced vital capacity and forced expiratory volume in 1 s (3.2% and 1.7% versus 1.7% and 0.9%, respectively) and manifold increased yearly rate of loss of lean body mass (0.18 kg·m(-2) versus 0.03 kg·m(-2) among those who did not desaturate).Desaturating COPD patients had a significantly worse prognosis than non-desaturating COPD patients, for multiple important disease outcomes. PMID:27076586

  3. Factors modifying stress from adverse effects of immunosuppressive medication in kidney transplant recipients

    NARCIS (Netherlands)

    Rosenberger, J.; Geckova, A.M.; van Dijk, J.P.; Roland, R.; Groothoff, J.W.

    2005-01-01

    Introduction: The adverse effects of immunosuppression appear in the majority of patients with a negative impact on morbidity, mortality and quality of life. The group of adverse symptoms manifested as changes in appearance, mood and energy are often more stressful than serious metabolic changes bec

  4. Bmi-1 expression predicts prognosis in salivary adenoid cystic carcinoma and correlates with epithelial-mesenchymal transition-related factors.

    Science.gov (United States)

    Yi, Chun; Li, Bin-Bin; Zhou, Chuan-Xiang

    2016-06-01

    Salivary adenoid cystic carcinoma (AdCC) is known for its high propensity to invade and metastasize. Bmi-1 acts as an oncogene by controlling cell cycle and self-renewal of adult stem cells, and its overexpression correlates with metastasis and poor prognosis in several cancers. Epithelial-mesenchymal transition (EMT) plays a central role in cancer metastasis. A key step in EMT is the down-regulation of E-cadherin that can be repressed by the transcriptional factors, such as Snail and Slug. In the present study, we investigated Bmi-1, Snail, Slug, and E-cadherin expression by immunohistochemistry in 102 patients with AdCC and analyzed statistically whether their expression correlated with clinicopathologic factors and prognosis. Reverse transcription-polymerase chain reaction was also performed in 22 tumor tissues and the adjacent noncancerous tissues to confirm Bmi-1 status in AdCCs. Our data demonstrated significant associations between the tumor metastasis and the expression of Bmi-1, Snail, Slug, and E-cadherin. Furthermore, a high level of Bmi-1 was not only correlated with the overexpression of Snail and Slug but also indicated an unfavorable metastasis-free survival and served as a high-risk marker for AdCC. In addition, Bmi-1 messenger RNA level was found much higher in AdCC tissues than in the adjacent noncancerous salivary gland tissues. Our results suggest that Bmi-1 may play a crucial role in AdCC progression by interaction with EMT-related markers and predict poor survival. PMID:27180058

  5. Expression of the Stem Cell Factor Nestin in Malignant Pleural Mesothelioma Is Associated with Poor Prognosis.

    Directory of Open Access Journals (Sweden)

    Svenja Thies

    Full Text Available The epithelioid and sarcomatoid histologic variants of malignant pleural mesothelioma (MPM can be considered as E- and M-parts of the epithelial-mesenchymal transition (EMT axis; the biphasic being an intermediate. EMT is associated with an increase of stem cell (SC traits. We correlated the neural crest SC marker nestin and the EMT marker periostin with histology, type of neo-adjuvant chemotherapy (CT and overall survival (OS of MPM patients.Tumor tissues of a historic cohort 1 (320 patients and an intended induction chemotherapy followed by extrapleural pneumonectomy (EPP cohort 2 (145 patients were immunohistochemically H-scored (intensity of immunoreactivity multiplied by frequency of stained cells. Paired chemo-naïve biopsies and -treated surgical specimens were available for 105/145 patients. CT included platinum/gemcitabine (Pla/Gem or platinum/pemetrexed (Pla/Pem.Expression of any cytosolic nestin progressively increased from epithelioid to biphasic to sarcomatoid MPM in cohort 1, whereas the diagnostic markers calretinin and podoplanin decreased. In cohort 2, Pla/Pem CT increased the expression level of nestin in comparison to Pla/Gem, whereas the opposite was found for periostin. In Pla/Pem treated patients, nestin was higher in biphasic MPM compared to epithelioid. In addition to non-epithelioid histology, any expression of nestin in chemo-naïve biopsies (median overall survival: 22 vs. 17 months and chemo-treated surgical specimens (18 vs. 12 months as well as high periostin in biopsies (23 vs. 15 months were associated with poor prognosis. In the multivariate survival analysis, any nestin expression in chemo-naïve biopsies proved to be an independent prognosticator against histology. In both pre- and post-CT situations, the combination of nestin or periostin expression with non-epithelioid histology was particularly/ dismal (all p-values <0.05.The SC marker nestin and the EMT marker periostin allow for further prognostic

  6. Causal Factors and Adverse Events of Aviation Accidents and Incidents Related to Integrated Vehicle Health Management

    Science.gov (United States)

    Reveley, Mary S.; Briggs, Jeffrey L.; Evans, Joni K.; Jones, Sharon M.; Kurtoglu, Tolga; Leone, Karen M.; Sandifer, Carl E.

    2011-01-01

    Causal factors in aviation accidents and incidents related to system/component failure/malfunction (SCFM) were examined for Federal Aviation Regulation Parts 121 and 135 operations to establish future requirements for the NASA Aviation Safety Program s Integrated Vehicle Health Management (IVHM) Project. Data analyzed includes National Transportation Safety Board (NSTB) accident data (1988 to 2003), Federal Aviation Administration (FAA) incident data (1988 to 2003), and Aviation Safety Reporting System (ASRS) incident data (1993 to 2008). Failure modes and effects analyses were examined to identify possible modes of SCFM. A table of potential adverse conditions was developed to help evaluate IVHM research technologies. Tables present details of specific SCFM for the incidents and accidents. Of the 370 NTSB accidents affected by SCFM, 48 percent involved the engine or fuel system, and 31 percent involved landing gear or hydraulic failure and malfunctions. A total of 35 percent of all SCFM accidents were caused by improper maintenance. Of the 7732 FAA database incidents affected by SCFM, 33 percent involved landing gear or hydraulics, and 33 percent involved the engine and fuel system. The most frequent SCFM found in ASRS were turbine engine, pressurization system, hydraulic main system, flight management system/flight management computer, and engine. Because the IVHM Project does not address maintenance issues, and landing gear and hydraulic systems accidents are usually not fatal, the focus of research should be those SCFMs that occur in the engine/fuel and flight control/structures systems as well as power systems.

  7. Identifying the Prognosis Factors in Death after Liver Transplantation via Adaptive LASSO in Iran

    Directory of Open Access Journals (Sweden)

    Hadi Raeisi Shahraki

    2016-01-01

    Full Text Available Despite the widespread use of liver transplantation as a routine therapy in liver diseases, the effective factors on its outcomes are still controversial. This study attempted to identify the most effective factors on death after liver transplantation. For this purpose, modified least absolute shrinkage and selection operator (LASSO, called Adaptive LASSO, was utilized. One of the best advantages of this method is considering high number of factors. Therefore, in a historical cohort study from 2008 to 2013, the clinical findings of 680 patients undergoing liver transplant surgery were considered. Ridge and Adaptive LASSO regression methods were then implemented to identify the most effective factors on death. To compare the performance of these two models, receiver operating characteristic (ROC curve was used. According to the results, 12 factors in Ridge regression and 9 ones in Adaptive LASSO regression were significant. The area under the ROC curve (AUC of Adaptive LASSO was equal to 89% (95% CI: 86%–91%, which was significantly greater than Ridge regression (64%, 95% CI: 61%–68% (p<0.001. As a conclusion, the significant factors and the performance criteria revealed the superiority of Adaptive LASSO method as a penalized model versus traditional regression model in the present study.

  8. Curative effects, prognostic factors, and adverse reactions of different treatment modalities of chemotherapy in patients with non-small cell lung cancer

    International Nuclear Information System (INIS)

    Objective: To explore the curative effects,prognostic factors,and adverse reactions of different treatment modalities of chemotherapy in patients with non-small cell lung cancer (NSCLC). Methods: 151 NSCLC patients were randomly assigned into 3 groups to undergo concurrent chemoradiotherapy (n=43), sequential chemo-radiotherapy (n=49), or pure chemotherapy (n=59). The clinical data were analyzed. Results: The short-term effective rates of the concurrent and sequential chemo-radiotherapy groups were 81.4% and 73.5% respectively with no significantly difference between them, but both significantly higher than that of the pure chemotherapy group (39.0%, both P<0.05). The mortality of the concurrent chemo-radiation group was 53.5%, significantly lower than those of the sequential chemo-radiotherapy and pure chemotherapy groups (67.3% and 67.8% respectively, both P<0.05). The median survival time of the concurrent chemo-radiotherapy group was 26 months,significantly longer than those of the sequential chemo-radiotherapy and pure chemotherapy groups (12 and 11 months respectively, both P<0.05). The l-year survival rates of the 3 groups were 80.2%, 47.1%, and 45.6%. The 2-year survival rates were 58.2%, 38.5%, and 24.4%, and the 3-year survival rates were 32.7%, 27.5%, and 0, respectively. The white blood cell decrease rates of the grades Ⅲ∼Ⅳ of the concurrent chemo-radiotherapy group were significantly higher than those of the other 2 groups (both P<0.05). There were no significant differences in the rates of radiation esophagitis and radiation pneumonitis between the concurrent and sequential chemo-radiotherapy groups. Age, performance status score, clinical staging, and treatment modality were the 4 influencing factors in the prognosis of NSCLC (all P<0.05). Conclusion: Relatively safe with tolerable adverse reactions, concurrent chemo-radiotherapy is superior to sequential chemo-radiotherapy, particularly to pure chemotherapy, in increase of median survival time

  9. Risk factors and prognosis of ischemic stroke in young patients in Uzbekistan

    Directory of Open Access Journals (Sweden)

    Khurshidakhon Rasulova

    2011-03-01

    Full Text Available Between 2004 and 2008, we studied reasons and risk factors of ischemic stroke in 150 young patients (aged between 17-44 years, compared with those in elderly patients (n=70. According to our data, heredity, arterial hypertension, cerebral vasculitis, thyroid diseases, chronic alcoholism, smoking and long-term use of oral contraceptives are main risk factors of ischemic stroke in the young in Uzbekistan. However, relative risk of stroke in this group of patients is less than in elder patients. In 16% cases, usage of standard diagnostic measures does not lead to identification of the disease cause.

  10. Potentially reversible factors during the very acute phase of stroke and their impact on the prognosis

    DEFF Research Database (Denmark)

    Jørgensen, H S; Reith, J; Nakayama, H;

    2001-01-01

    progression with an OR of 2.9. However, the combined effect of all three factors was more than additive with an OR of 10.0 (95% CI 1.5-56; p <0.01). We have shown that in human stroke a strong and more than additive association exists between potentially reversible parameters and outcome. Intervention trials...

  11. Transitional cell carcinoma of the bladder : histopathological and biological factors and prognosis

    NARCIS (Netherlands)

    R.F.M. Schapers

    1993-01-01

    textabstractThe main purpose of the studies reported in this thesis has been to determine the extent to which the behaviour of TCC can be predicted by histopathological and biological characteristics. The potential additional prognostic value of these factors was evaluated by combining them with oth

  12. Perioperative factors related to prognosis of regular hepatectomy in comparison with irregular hepatectomy

    Institute of Scientific and Technical Information of China (English)

    Feng Zhiqiang; Li Hongqi; Zhang Jinqian; Xu Lining; Xiao Mei; Huang Zhiqiang; Zhang Hongyi

    2014-01-01

    Background The aim of this research was to analyze the perioperative factors of regular hepatectomy and irregular hepatectomy.The superiority of the clinical application of the two methods was compared in the perioperative period.Methods From 1986 to 2011,1798 patients underwent consecutive liver resections with regular hepatectomy and irregular hepatectomy at the Air Force General Hospital of People's Liberation Army and the General Hospital of Chinese People's Liberation Army.Their medical documentation was investigated retrospectively.Results In patients on whom regular hepatectomy and irregular hepatectomy were performed,there was no significant difference in perioperative blood loss,complications,in-hospital mortality,hospital stay,and so on.But in regular hepatectomy,operating time was an independent risk factor (P <0.001,OR=1.004).Conclusions There was no significant difference between the perioperative risk of regular hepatectomy and that of irregular hepatectomy.

  13. Obesity and smoking are factors associated with poor prognosis in patients with bacteraemia

    OpenAIRE

    Vuento Risto; Lumio Jukka; Laine Janne; Huttunen Reetta; Syrjänen Jaana

    2007-01-01

    Abstract Background Bacteraemia is still a major cause of case fatality in all age groups. Our aim was to identify the major underlying conditions constituting risk factors for case fatality in bacteraemia patients. Methods The study involved 149 patients (79 male and 70 female) with bacteraemia caused by Staphylococcus aureus (S. aureus) (41 patients), Streptococcus pneumoniae (Str. pneumoniae) (42 patients), β-hemolytic streptococcae (β-hml str.) (23 patients) and Eschericia coli (E. coli) ...

  14. Statistical count models for prognosis the risk factors of hepatitis C

    OpenAIRE

    Pourhoseingholi, Asma; Baghban, Alireza Akbarzadeh; Zayeri, Farid; Alavian, Seyed Moayed; Vahedi, Mohsen

    2013-01-01

    Aim The aim of this study was to compare alternatives methods for analysis of zero inflated count data and compare them with simple count models that are used by researchers frequently for such zero inflated data. Background Analysis of viral load and risk factors could predict likelihood of achieving sustain virological response (SVR). This information is useful to protect a person from acquiring Hepatitis C virus (HCV) infection. The distribution of viral load contains a large proportion of...

  15. Hormone-related factors and breast cancer : studies of risk and prognosis

    OpenAIRE

    Rosenberg, Lena

    2006-01-01

    The main purpose of this thesis was to explore the influences of risk factors for breast cancer on breast cancer characteristics and survival. We evaluated the associations between number and timing of births and breast cancerspecific survival using data from the Swedish Cancer Register, the Swedish Cause of Death Register, and the MultiGeneration Register. We identified more than 27,000 women born in Sweden and diagnosed with breast cancer in 1958-1997. We found a successiv...

  16. Peripartum cardiomyopathy: risk factors, hospital course and prognosis; experiences at lady reading hospital Peshawar

    International Nuclear Information System (INIS)

    Objective: To study the so-called risk factors associated with peripartum cardiomyopathy (PPCM), its hospital course, short and long term mortality and outcome of subsequent pregnancies. Methodology: A total of 61 patients diagnosed with PPCM were enrolled in the study. Data regarding risk factors, presenting complaints, complications, pregnancy outcomes, therapeutics used and outcome at 3, 6 and 12 months were recorded. Results: The incidence was estimated to be 1 per 933 deliveries. Mean age +- SD was 30.94+-6.63 years. Majority of patients 33(54.1%) were obese. The mean parity was 3.66 +- 1.41. Other risk factors were chronic hypertension 19 (31.1%), pre-eclampsia 12 (19.7%) and multiple pregnancies 5(8.2%). Forty-three patients 43(70.5%) presented in post partum period while 18 (29.5%) in antepartum period. All patients presented with dyspnea. Main ECG findings were sinus tachycardia 39 (63.9%), LV hypertrophy 42 (68.9%) and T wave inversion 28(45.9%). Ejection fraction was universally reduced on echocardiography. There were 50(82%) live births and 11(18%) perinatal deaths. Main complications were pulmonary edema 7(11.5%), cardiogenic shock 8(13.1%) and thromboembolism 13(21.3%). At hospital discharge, 9 (14.8%) patients were dead and 52(85.2%) were discharged with stable heart failure. At 12 month follow up, a total of 20(32.8%) were dead while 32(52.5%) had recovered fully and 9(14.75%) were still suffering from heart failure. During follow up, only 8(19.5%) pregnancies were detected. Five (62.5%) patients had uneventful course while 3(37.5%) developed heart failure again. Conclusion: Peripartum cardiomyopathy is associated with multiple risk factors and carries high morbidity and mortality. (author)

  17. Freezing adversely affects measurement of vascular endothelial growth factor levels in human aqueous samples

    Directory of Open Access Journals (Sweden)

    Sankarathi Balaiya

    2011-01-01

    Full Text Available Sankarathi Balaiya Sandeep Grover Ravi K Murthy Kakarla V ChalamDepartment of Ophthalmology, University of Florida College of Medicine, Jacksonville, FL, USAPurpose: Aqueous levels of vascular endothelial growth factor (VEGF can be a surrogate marker of intraocular VEGF activity and a measure of efficacy of anti-VEGF treatment in a variety of vasoproliferative retinal disorders, including diabetic retinopathy, age-related macular degeneration, and central retinal vein occlusion. Measurement of the VEGF level may be adversely affected by premeasurement variables, such as freezing and delay, in sample analysis. We aim to evaluate the effect of storage and delayed measurement of human aqueous VEGF levels in these conditions.Methods: Aqueous samples collected from patients receiving intravitreal injection of bevacizumab for various retinal diseases were divided into two groups. In Group 1, the VEGF levels were analyzed on the same day; in Group 2, the VEGF levels were analyzed after 21 days of freezer storage (-80°C using immunobead assay. Statistical comparison using a paired t-test was performed between the two groups.Results: Thirty-one aqueous humor samples were collected, and the VEGF concentration for fresh samples was 7.8 ± 5.9 pg/mL (mean ± SD compared to 6.5 ± 6.0 pg/mL in frozen samples, resulting in a statistically significant difference (P = 0.03.Conclusions: Accurate measurement of the VEGF level is a vital component of clinical decision-making. Delayed analysis of VEGF levels in aqueous samples may result in significant sample degradation and lower levels of measured VEGF.Keywords: VEGF level, aqueous humor, immunobead assay, VEGF storage

  18. Obesity and smoking are factors associated with poor prognosis in patients with bacteraemia

    Directory of Open Access Journals (Sweden)

    Vuento Risto

    2007-03-01

    Full Text Available Abstract Background Bacteraemia is still a major cause of case fatality in all age groups. Our aim was to identify the major underlying conditions constituting risk factors for case fatality in bacteraemia patients. Methods The study involved 149 patients (79 male and 70 female with bacteraemia caused by Staphylococcus aureus (S. aureus (41 patients, Streptococcus pneumoniae (Str. pneumoniae (42 patients, β-hemolytic streptococcae (β-hml str. (23 patients and Eschericia coli (E. coli (43 patients. Underlying diseases, alcohol and tobacco consumption and body mass index (BMI were registered. Laboratory findings and clinical data were registered on admission and 6 consecutive days and on day 10–14. Case fatality was studied within 30 days after positive blood culture. Associations between underlying conditions and case fatality were studied in univariate analysis and in a multivariate model. Results Nineteen patients (12.8% died of bacteraemia. We found obesity (p = 0.002, RR 9.8; 95% CI 2.3 to 41.3, smoking (p Conclusion Our results indicate that obesity and smoking are prominent risk factors for case fatality in bacteraemic patients. Identification of risk factors underlying fatal outcome in bacteraemia may allow targeting of preventive efforts to individuals likely to derive greatest potential benefit.

  19. Incidence and risk factors of bleeding-related adverse events in patients with chronic lymphocytic leukemia treated with ibrutinib

    OpenAIRE

    Lipsky, Andrew H.; Farooqui, Mohammed Z.H.; Tian, Xin; Martyr, Sabrina; Cullinane, Ann M.; Nghiem, Khanh; Sun, Clare; Valdez, Janet; Niemann, Carsten U.; Herman, Sarah E. M.; Saba, Nakhle; Soto, Susan; Marti, Gerald; Uzel, Gulbu; Holland, Steve M.

    2015-01-01

    Ibrutinib is associated with bleeding-related adverse events of grade ≤2 in severity, and infrequently with grade ≥3 events. To investigate the mechanisms of bleeding and identify patients at risk, we prospectively assessed platelet function and coagulation factors in our investigator-initiated trial of single-agent ibrutinib for chronic lymphocytic leukemia. At a median follow-up of 24 months we recorded grade ≤2 bleeding-related adverse events in 55% of 85 patients. No grade ≥3 events occur...

  20. Radiation treatment of glottic squamous cell carcinoma, Stage I and II: analysis of factors affecting prognosis

    International Nuclear Information System (INIS)

    Purpose: At least in some European Countries, there is still considerable controversy regarding the choice between surgery and radiotherapy for the treatment of patients with early laryngeal-glottic carcinoma. Methods and Materials: Two hundred and forty-six patients with laryngeal-glottic neoplasms, Stage I-II, were treated with radical radiotherapy. Before radiotherapy the patients were evaluated to determine the surgical procedure of choice. Either 66-68.4 Gy (33-38 fractions) or 63-65 Gy (28-29 fractions) of radiation therapy (RT) were administered. The overall disease free survival was determined for each subgroup of patients. Univariate and multivariate analyses were performed to determine significant prognostic variables. Results: Five- and 10-year overall survival rates were 83 and 72%, respectively. At a median follow-up of 6 years 204 patients are alive and disease free. No patient developed distant metastases. One patient died of a large local recurrence, 38 patients died of causes unrelated to their tumor, and 3 patients were lost to follow-up. The multivariate analysis confirmed that performance status (PS), macroscopic presentation of the lesion, and persistence of dysphonia after radiotherapy are significant prognostic factors. Conclusions: According to the multivariate analysis, the patients with PS >80 and with exophytic lesions are eligible for radical RT. The surgical procedure proposed for each patient was not found to be an independent prognostic factor

  1. The efficiency of radiation therapy in the treatment of intracranial oligodendrogliomas: factors influencing the prognosis

    International Nuclear Information System (INIS)

    Oligodendrogliomas (ODG) are a rare, slow growing, tumor in the brain, which can be cured by complete surgical resection, but as yet it is not known if postoperative adjuvant radiation therapy (RT) is essential. We analyzed the treatment results of patients with irradiated ODG to investigate the efficacy of RT in terms of survival rates and other influencing prognostic factors. Between March 1983 and December 1997, 42 patients with ODG were treated with RT at our hospital. The RT was performed daily at a dose of 1.8 ∼ 2.0 Gy, at 5 fractions per week, to a total dose of between 39.6 Gy and 64.8 Gy (mean 53.3 Gy). The ages of the patients ranged between 5 and 62 years, with a median age of 39 years. The mean follow-up period was 63.4 months (8-152 months). The Kaplan-Meier method was used to assess the survival, and 5 year survival rates (5-YSR). Log rank tests and Cox regression analyses were used to define the significance of prognostic factors. The majority of ODG in this study were located in the cerebral hemisphere (83.3%). ODG are slightly more common in men than women, and commonly occurs in middle age, between the 3rd and 4th decades. It has been recommended that RT is commenced within 4 weeks following surgery (5-YSR; 86% vs. 49%; ρ 0.05). A local involved field irradiation with conventional fractionation, commencing within 4 weeks following surgical excision of the tumor, was beneficial for the 5-YSR, but a total radiation dose exceeding 60 Gy did not improve the 5-YSR

  2. 频发房性早搏与新发心房颤动及不良预后的关系%The relationship between frequent premature atrial complexes and new occurrence of atrial fibrillation and adverse prognosis

    Institute of Scientific and Technical Information of China (English)

    丽英

    2014-01-01

    Objectives To investigate the relation between baseline frequency of premature atrial complexes (PACs) and new-onset atrial fibrillation (NAF) and adverseprognosis. Methods Patients without AF or structural heart disease undergoing 24 h electrocardiography monitoring for palpitations,dizziness,or syncope were recruited. Baseline characteristics and 18-monthNAF and adverse events (ischemic stroke,heart failure,and death) were collected. Results 96 patients with number of PACs at the topquartile (>98 PACs/day) were defined to have frequent PACs. After 18 months follow-up, 28 patients (29%) with frequent PACs developed AF compared with 26 patients (9%) with PACs≤98/day (P<0.01).Cox regression analysis revealed that frequent PACs [hazard ratio (HR):3.22 (95% confidence interval (CI):1.93~5.41; P<0.05)] was independent predictors for new AF. Patients with frequent PACs were more at risk for adverse events than those without frequent PACs (34.4vs19.4%,P<0.05).Cox regression analysis showed that frequent PACs (HR:1.58;95%CI:1.13~2.51;P=0.03)was independent predictor for the adverse events. Conclusion Frequent PACs predict new AF and adverse prognosis.%目的:评估频发房性早搏(permature atrial complexes,PACs)与新发心房颤动(new-onset atrial fibrillation,NAF)及不良预后的关系。方法连续入选因心悸、眩晕或晕厥入院的患者,收集患者基线资料,记录18个月内的NAF及不良事件(缺血性卒中、充血性心力衰竭及死亡)。结果根据患者Holter检查记录的PACs次数将患者分为2组,频发PACs组患者年龄较高,左房较大,射血分数较低。18个月后,频发PACs组患者NAF(29.2%vs9.0%,P<0.05)及不良事件(34.4%vs19.4%,P<0.05)发生率高于无频发PACs组患者。Cox回归分析也显示,频发PACs是NAF及不良事件的独立危险因素(P<0.05)。结论频发PACs可预测患者的AF发生及不良预后。

  3. Nerve growth factor expression in astrocytoma and cerebrospinal fluid: a new biomarker for prognosis of astrocytoma

    Institute of Scientific and Technical Information of China (English)

    LI Qiao-yu; FENG Yun; XU Wen-lin; YANG Yong; ZHANG Yan; ZHANG Zhi-jian; GONG Ai-hua; YUAN Zhi-cheng; LU Pei-song; ZHAN Li-ping; WANG Peng

    2011-01-01

    Background Recent studies have discovered that nuclear translocation of nerve growth factor (NGF) and its receptor fragments function differently from the traditional model. This study aimed to uncover the nuclear expression of NGF in astrocytoma and its biological significance.Methods Ninety-four paraffin-embedded astrocytoma specimens were subjected to immunohistochemical (IHC) and hemotoxylin & eosin (HE) staining. Preoperative cerebrospinal fluid (CSF) specimens and intraoperative snap-frozen astrocytoma tissues were assayed for NGF expression by ELISA and Western blotting. The outcome of patients who contributed samples was tracked. Each ten tissue samples from patients with traumatic brain injury who had received decompression surgery and CSF samples from patients undergoing spinal anesthesia but with no history of nervous system disease were taken as control.Results NGF-positive immunoreactive products were distributed in both the cytoplasm and nucleus of astrocytoma, but were only located in the cytoplasm of traumatic brain injury (TBI) tissue. NGF nuclear-positive rate (NPR) of grades Ⅲ-Ⅳ astrocytomas (70.0%) was higher than that of grades Ⅰ-Ⅱ astrocytoma (28.6%, P<0.05). NGF-NP expression positively correlated with the NGF concentration in cerebrospinal fluid (CSF) (r=0.755, P<0.01). Kaplan-Meier survival analysis indicated that the median survival time was 25 months for NGF-NP astrocytoma grade Ⅰ-Ⅱ patients and 42 months in NGF nuclear negative (NGF-NN) astrocytoma grade Ⅰ-Ⅱ patients (P<0.05). In astrocytoma Ⅲ-Ⅳ patients, the median survival was 7 months for NGF-NP patients and 24 months for NGF-NN patients (P<0.01). Two types of NGF with molecular weights of 13 and 36 kDa were present in astrocytoma, but only the 36 kDa NGF was found in the CSF. NGF expression elevated as the malignancy increased.Conclusions NGF-NP expression and NGF level in CSF were significant prognostic factors in astrocytoma patients.Because of the easy

  4. Obesity might be a good prognosis factor for COPD patients using domiciliary noninvasive mechanical ventilation

    Science.gov (United States)

    Altinoz, Hilal; Adiguzel, Nalan; Salturk, Cuneyt; Gungor, Gokay; Mocin, Ozlem; Berk Takir, Huriye; Kargin, Feyza; Balci, Merih; Dikensoy, Oner; Karakurt, Zuhal

    2016-01-01

    Cachexia is known to be a deteriorating factor for survival of patients with chronic obstructive pulmonary disease (COPD), but data related to obesity are limited. We observed that obese patients with COPD prescribed long-term noninvasive mechanical ventilation (NIMV) had better survival rate compared to nonobese patients. Therefore, we conducted a retrospective observational cohort study. Archives of Thoracic Diseases Training Hospital were sought between 2008 and 2013. All the subjects were prescribed domiciliary NIMV for chronic respiratory failure secondary to COPD. Subjects were grouped according to their body mass index (BMI). The first group consisted of subjects with BMI between 20 and 30 kg/m2, and the second group consisted of subjects with BMI >30 kg/m2. Data obtained at the first month’s visit for the following parameters were recorded: age, sex, comorbid diseases, smoking history, pulmonary function test, 6-minute walk test (6-MWT), and arterial blood gas analysis. Hospital admissions were recorded before and after the domiciliary NIMV usage. Mortality rate was searched from the electronic database. Overall, 118 subjects were enrolled. Thirty-eight subjects had BMI between 20 and 30 kg/m2, while 80 subjects had BMI >30 kg/m2. The mean age was 65.8±9.4 years, and 81% were male. The median follow-up time was 26 months and mortality rates were 32% and 34% for obese and nonobese subjects (P=0.67). Improvement in 6-MWT was protective against mortality. In conclusion, survival of obese patients with COPD using domiciliary NIMV was found to be better than those of nonobese patients, and the improvement in 6-MWT in such patients was found to be related to a better survival.

  5. Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients

    Directory of Open Access Journals (Sweden)

    Nugnes Loredana

    2010-02-01

    Full Text Available Abstract Background Cutaneous melanoma (CM is the most lethal form of skin malignancy, which registers a constant increase in incidence worldwide. The identification of molecular alteration(s involved in its biological aggressiveness represents a major challenge for researchers, considering that existing therapies are ineffective to treat metastasizing cases. The epigenetic control of chromatin dynamics during DNA synthesis, replication, and repair is fundamental for the orderly progression of cell proliferation. The Chromatin Assembly Factor 1 (CAF-1 complex acts as a major regulator of this process; its intermediate (p60 subunit has been recently proposed as a novel proliferation and prognostic marker for several tumors. We aimed to establish if the evaluation of the expression of CAF-1/p60 in primary CM may help define the prevision of outcome of patients. Methods Immunohistochemistry with anti-CAF-1/p60 was performed on paraffin-embedded tissue sections of 130 cases of primary CM retrieved from the archive files of the Department of Biomorphological and Functional Sciences, Section of Pathology, University "Federico II" of Naples, Italy. Results were compared with histopathological and follow-up data of patients. Results CAF-1/p60 was expressed in all CM. A significant statistical association between the overexpression of the protein and the occurrence of skin, node and/or distant metastases (P Conclusions CAF-1/p60 looks promising as a new prognostic marker for CM and sheds new light on the molecular events associated with photocancerogenesis and melanoma biology. The screening for CAF-1/p60 might contribute to the molecular sub-classification of CM, with improved translational outcomes.

  6. Obesity might be a good prognosis factor for COPD patients using domiciliary noninvasive mechanical ventilation.

    Science.gov (United States)

    Altinoz, Hilal; Adiguzel, Nalan; Salturk, Cuneyt; Gungor, Gokay; Mocin, Ozlem; Berk Takir, Huriye; Kargin, Feyza; Balci, Merih; Dikensoy, Oner; Karakurt, Zuhal

    2016-01-01

    Cachexia is known to be a deteriorating factor for survival of patients with chronic obstructive pulmonary disease (COPD), but data related to obesity are limited. We observed that obese patients with COPD prescribed long-term noninvasive mechanical ventilation (NIMV) had better survival rate compared to nonobese patients. Therefore, we conducted a retrospective observational cohort study. Archives of Thoracic Diseases Training Hospital were sought between 2008 and 2013. All the subjects were prescribed domiciliary NIMV for chronic respiratory failure secondary to COPD. Subjects were grouped according to their body mass index (BMI). The first group consisted of subjects with BMI between 20 and 30 kg/m(2), and the second group consisted of subjects with BMI >30 kg/m(2). Data obtained at the first month's visit for the following parameters were recorded: age, sex, comorbid diseases, smoking history, pulmonary function test, 6-minute walk test (6-MWT), and arterial blood gas analysis. Hospital admissions were recorded before and after the domiciliary NIMV usage. Mortality rate was searched from the electronic database. Overall, 118 subjects were enrolled. Thirty-eight subjects had BMI between 20 and 30 kg/m(2), while 80 subjects had BMI >30 kg/m(2). The mean age was 65.8±9.4 years, and 81% were male. The median follow-up time was 26 months and mortality rates were 32% and 34% for obese and nonobese subjects (P=0.67). Improvement in 6-MWT was protective against mortality. In conclusion, survival of obese patients with COPD using domiciliary NIMV was found to be better than those of nonobese patients, and the improvement in 6-MWT in such patients was found to be related to a better survival. PMID:27578969

  7. Adverse reactions, psychological factors, and their effect on donor retention in men and women

    NARCIS (Netherlands)

    Veldhuizen, I.; Atsma, F.; Dongen, A. van; Kort, W. de

    2012-01-01

    BACKGROUND: This study investigates the effect of a vasovagal reaction (VVR) or needle reaction (NR) on the risk of stopping as a blood donor, taking into account variables from the Theory of Planned Behavior (TPB). Is stopping risk solely related to the adverse reaction itself, or do the TPB variab

  8. The Role of ADHD in Academic Adversity: Disentangling ADHD Effects from Other Personal and Contextual Factors

    Science.gov (United States)

    Martin, Andrew J.

    2014-01-01

    Students with attention-deficit/hyperactivity disorder (ADHD) experience significant academic difficulties that can lead to numerous negative academic consequences. With a focus on adverse academic outcomes, this study seeks to disentangle variance attributable to ADHD from variance attributable to salient personal and contextual covariates.…

  9. The Association between Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 Levels and Clinical Prognosis in Patients with Ischemic Stroke

    Directory of Open Access Journals (Sweden)

    Hasan Yaşar

    2015-04-01

    Full Text Available OBJECTIVE: Recent studies report that the insulin-like growth factor system may be involved in stroke pathogenesis, and is reported to increase myelination, maturation, cell proliferation and neuronal sprouting of the central nervous system. The aim of the present study is to demonstrate the role of insulin-like growth factor system in ischemic stroke pathogenesis and its association with the prognosis by investigating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels in patients diagnosed with acute ischemic stroke. METHODS: : Sixty-eight patients and 20 healthy individuals were included to this study. Clinical evaluation of the patients was performed according to National Institute of Health Stroke Scale and functional outcomes were graded according to Modified Rankin Scale. Bamford classification was used for the clinical classification of ischemic strokes, and the TOAST system for etiological classification. Each patient's levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 were measured on the first, fifth and thirtieth day of ischemic stroke. RESULTS: Only the levels of insulin-like growth factor binding protein-3 on the day of 5 were significantly decreased compared to the control group. The decrease in IGF-1 values was associated with an increased risk of death and was accompanied by clinical worsening and decreased functionality. CONCLUSION: It has been concluded that the levels of investigating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 may affect mortality risk, clinical condition and functionality outcomes in patients presenting with ischemic stroke, and further studies are needed for the investigation of different effects of insulin-like growth factor-1 in future.

  10. Impact of early psychosocial factors (childhood socioeconomic factors and adversities) on future risk of type 2 diabetes, metabolic disturbances and obesity: a systematic review

    OpenAIRE

    Tamayo Teresa; Christian Herder; Rathmann Wolfgang

    2010-01-01

    Abstract Background Psychological factors and socioeconomic status (SES) have a notable impact on health disparities, including type 2 diabetes risk. However, the link between childhood psychosocial factors, such as childhood adversities or parental SES, and metabolic disturbances is less well established. In addition, the lifetime perspective including adult socioeconomic factors remains of further interest. We carried out a systematic review with the main question if there is evidence in po...

  11. APCR, factor V gene known and novel SNPs and adverse pregnancy outcomes in an Irish cohort of pregnant women

    LENUS (Irish Health Repository)

    Sedano-Balbas, Sara

    2010-03-10

    Abstract Background Activated Protein C Resistance (APCR), a poor anticoagulant response of APC in haemostasis, is the commonest heritable thrombophilia. Adverse outcomes during pregnancy have been linked to APCR. This study determined the frequency of APCR, factor V gene known and novel SNPs and adverse outcomes in a group of pregnant women. Methods Blood samples collected from 907 pregnant women were tested using the Coatest® Classic and Modified functional haematological tests to establish the frequency of APCR. PCR-Restriction Enzyme Analysis (PCR-REA), PCR-DNA probe hybridisation analysis and DNA sequencing were used for molecular screening of known mutations in the factor V gene in subjects determined to have APCR based on the Coatest® Classic and\\/or Modified functional haematological tests. Glycosylase Mediated Polymorphism Detection (GMPD), a SNP screening technique and DNA sequencing, were used to identify SNPs in the factor V gene of 5 APCR subjects. Results Sixteen percent of the study group had an APCR phenotype. Factor V Leiden (FVL), FV Cambridge, and haplotype (H) R2 alleles were identified in this group. Thirty-three SNPs; 9 silent SNPs and 24 missense SNPs, of which 20 SNPs were novel, were identified in the 5 APCR subjects. Adverse pregnancy outcomes were found at a frequency of 35% in the group with APCR based on Classic Coatest® test only and at 45% in the group with APCR based on the Modified Coatest® test. Forty-eight percent of subjects with FVL had adverse outcomes while in the group of subjects with no FVL, adverse outcomes occurred at a frequency of 37%. Conclusions Known mutations and novel SNPs in the factor V gene were identified in the study cohort determined to have APCR in pregnancy. Further studies are required to investigate the contribution of these novel SNPs to the APCR phenotype. Adverse outcomes including early pregnancy loss (EPL), preeclampsia (PET) and intrauterine growth restriction (IGUR) were not significantly more

  12. Circulating angiogenic factors and risk of adverse maternal and perinatal outcomes in twin pregnancies with suspected preeclampsia.

    Science.gov (United States)

    Rana, Sarosh; Hacker, Michele R; Modest, Anna Merport; Salahuddin, Saira; Lim, Kee-Hak; Verlohren, Stefan; Perschel, Frank H; Karumanchi, S Ananth

    2012-08-01

    To evaluate whether angiogenic factor levels correlate with preeclampsia-related adverse maternal and perinatal outcomes in women with twin pregnancy, we studied 79 women with suspected preeclampsia in the 3rd trimester. Antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt-1) and proangiogenic placental growth factor (PlGF) were measured at presentation on an automated platform. An adverse outcome was defined as hemolysis, elevated liver enzymes, and low platelets syndrome; disseminated intravascular coagulation; abruption; pulmonary edema; cerebral hemorrhage; maternal, fetal, and neonatal death; eclampsia; acute renal failure; small for gestational age; and indicated delivery. All outcomes were ascertained 2 weeks after initial evaluation. Comparing the 52 women (65.8%) who experienced an adverse outcome with the 27 women (34.2%) without an adverse outcome, the median sFlt-1 was elevated (11461.5 pg/mL [8794.0-14847.5] versus 7495.0 pg/mL [3498.0-10482.0; P=0.0004]), PlGF was reduced (162.5 pg/mL [98.0-226.5] versus 224.0 pg/mL [156.0-449.0]; P=0.005), and sFlt-1/PlGF ratio was elevated (74.2 [43.5-110.5] versus 36.2 [7.1-71.3]; P=0.0005). Among those presenting preeclampsia, the sFlt-1/PlGF ratio at the time of initial evaluation is associated with subsequent adverse maternal and perinatal outcomes. These findings are similar to those in singleton pregnancies and may implicate common pathogenic pathways. PMID:22753210

  13. A retrospective study on the incidences of adverse drug events and analysis of the contributing trigger factors

    OpenAIRE

    Sam, Aaseer Thamby; Lian Jessica, Looi Li; Parasuraman, Subramani

    2015-01-01

    Objectives: To retrospectively determine the extent and types of adverse drug events (ADEs) from the patient cases sheets and identify the contributing factors of medication errors. To assess causality and severity using the World Health Organization (WHO) probability scale and Hartwig's scale, respectively. Methods: Hundred patient case sheets were randomly selected, modified version of the Institute for Healthcare Improvement (IHI) Global Trigger Tool was utilized to identify the ADEs; caus...

  14. Patient-reported health as a prognostic factor for adverse events following percutaneous coronary intervention

    Directory of Open Access Journals (Sweden)

    Biering K

    2014-01-01

    Full Text Available Karin Biering,1 Hans Erik Bøtker,2 Troels Niemann,3 Niels Henrik Hjollund4,51Department of Occupational Medicine, Regional Hospital West Jutland, Herning, 2Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, 3Department of Cardiology, Regional Hospital West Jutland, Herning, 4WestChronic, Regional Hospital West Jutland, Herning, 5Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, DenmarkObjective: A relation may exist between self-reported health and adverse events in coronary heart disease. Previous studies have been vulnerable to possible selection bias. In the study reported here, we examined the association between self-rated health and adverse events in terms of cardiac events, cardiac readmissions, and all-cause mortality in a complete cohort of patients treated with percutaneous coronary intervention (PCI.Study design and setting: A cohort of patients with coronary heart disease treated with PCI was followed up with questionnaires 4 weeks after PCI to measure self-rated health and in registers to identify adverse events. Of 1,752 eligible patients under 67 years, 26 died during the first 4 weeks. A total of 224 patients were excluded from the analysis because they were readmitted with a cardiac diagnosis before answering the first questionnaire. We received complete SF-12 Health Survey component summaries from 984 of the remaining 1,502 patients. We used multiple imputation to establish a complete cohort, including nonrespondents.Results: During follow-up, 83 patients died, 220 patients experienced a new cardiac event, and 526 patients experienced a hospital readmission related to coronary heart disease. Poor self-rated health was related to cardiac events, cardiac readmission, and all-cause mortality. The associations were stronger for all-cause mortality than for events and readmissions. Physical health was more important than mental health, but both revealed an exposure–response pattern

  15. Incidence and risk factors of bleeding-related adverse events in patients with chronic lymphocytic leukemia treated with ibrutinib

    DEFF Research Database (Denmark)

    Lipsky, Andrew H; Farooqui, Mohammed Z H; Tian, Xin;

    2015-01-01

    Ibrutinib is associated with bleeding-related adverse events of grade ≤2 in severity, and infrequently with grade ≥3 events. To investigate the mechanisms of bleeding and identify patients at risk, we prospectively assessed platelet function and coagulation factors in our investigator-initiated t......Ibrutinib is associated with bleeding-related adverse events of grade ≤2 in severity, and infrequently with grade ≥3 events. To investigate the mechanisms of bleeding and identify patients at risk, we prospectively assessed platelet function and coagulation factors in our investigator......-initiated trial of single-agent ibrutinib for chronic lymphocytic leukemia. At a median follow-up of 24 months we recorded grade ≤2 bleeding-related adverse events in 55% of 85 patients. No grade ≥3 events occurred. Median time to event was 49 days. The cumulative incidence of an event plateaued by 6 months...... 19 patients on ibrutinib (often transiently). Collagen and adenosine diphosphate induced platelet aggregation was tested using whole blood aggregometry. Compared to normal controls, response to both agonists was decreased in all patients with chronic lymphocytic leukemia, whether on ibrutinib or not...

  16. Methylation of CTNNA1 promoter: frequent but not an adverse prognostic factor in acute myeloid leukemia.

    Science.gov (United States)

    Chen, Xing-xing; Lin, Jiang; Qian, Jun; Qian, Wei; Yang, Jing; Ma, Ji-chun; Deng, Zhao-qun; An, Cui; Tang, Chun-yan; Qian, Zhen; Liu, Qing

    2014-05-01

    The reduced expression of CTNNA1 gene, a putative tumor suppressor gene, has been found in several cancers including acute myeloid leukemia (AML). CTNNA1 expression is regulated by methylation and histone deacetylation. However, the clinical significance of CTNNA1 methylation in AML is rarely known. The present study was aimed to investigate the methylation status of CTNNA1 promoter region using methylation-specific PCR (MSP) and its clinical relevance in Chinese AML patients. Patients with CTNNA1 hypermethylation had significantly lower level of CTNNA1 transcript than those without CTNNA1 hypermethylation (P=0.031). The relationship of CTNNA1 methylation with clinical parameters was evaluated. Aberrant hypermethylation of CTNNA1 gene was found in 23.9% (37/155) AML cases. The status of CTNNA1 methylation was not correlated with the mutations of seven genes (FLT3-ITD, NPM1, C-KIT, IDH1/IDH2, DNMT3A, N/K-RAS and C/EBPA). There was no significant difference in the rates of complete remission (CR) between patients with and without CTNNA1 methylation. Although the overall survival (OS) time of the CTNNA1-methylated AML was shorter than that of CTNNA1-unmethylated group (6 months vs 9 months), the difference was not statistically significant (P=0.681). Our data suggest that CTNNA1 methylation is a recurrent event but has no influence on prognosis in AML. PMID:24685333

  17. The outcome and prognosis factors of adolescent nasopharyngeal carcinoma treated in a single institute-analysis of 148 patients

    International Nuclear Information System (INIS)

    Objective: To evaluate the clinical characteristics, outcome and prognostic factors of adolescent nasopharyngeal carcinoma. Methods: Between Jan 1990 and Dec 2009, totally 148 pathological confirmed nasopharyngeal carcinoma (NPC) patients with age ≤20 years were treated in our hospital, including stage II 8, stage III 58, stage IV 81, and unknown 1 when restaged by TNM system (UICC 2002), ninety-four (63.5%) patients were treated with radiotherapy alone, 54 (36.5%)patients were treated with radiotherapy combined with cisplatin-based chemotherapy. Results: The median follow-up time for all patients was 44.5 months. The 5-year overall survival (OS), local-regional control (LRC) and distant metastasis-free survival (DMFS) rates were 82.9%, 85.1% and 78.6%. There were 42 patients (28.4%) failed with 16 regional recurrence and 29 distant metastasis, and 3 with both; bone metastasis was the most common site of distant metastasis(22/29). In univariate analysis,the adverse prognostic factors for OS were stage T4(χ2=5.61, P=0.018), radiation dose 2=5.30, P=0.021), for LRC was radiation dose 2=4.24, P=0.039). In multivariate analysis, radiation dose 4 were the independent prognostic factors for OS (χ2=5.73, 5.56, P=0.017, 0.018), for LRC was radiation dose 2=5.81, P=0.016). Conclusions: The outcome of the present series was excellent, total nasopharyngeal radiation dose less than 70 Gy is inappropriate. Reduce the distant metastasis and late toxicities were the future direction for the treatment of adolescent nasopharyngeal carcinoma. (authors)

  18. Serum levels of vascular endothelial growth factor and cancer antigen 125 are related to the prognosis of adenomyosis patients after interventional therapy

    OpenAIRE

    MU, YONGXU; Hu, Xiaoyan; He, Junfeng; Liu, Haiyan; Zhang, Lei; Liu, Heming; Hao, Zhiming

    2015-01-01

    Aims: This study is to investigate the expression levels of vascular endothelial growth factor (VEGF) and cancer antigen 125 (CA125) in serum of adenomyosis patients before and after interventional therapy. The role of serum levels of VEGF and CA125 for the prognosis of adenomyosis is further studied. Methods: A total of 80 adenomyosis patients treated with interventional therapy and 40 healthy individuals were enrolled in this study. Enzyme-linked immunosorbent assay was performed to detect ...

  19. TFIIB-Related Factor 2 Over Expression Is a Prognosis Marker for Early-Stage Non-Small Cell Lung Cancer Correlated with Tumor Angiogenesis

    OpenAIRE

    Ming Lu; Hui Tian; Weiming Yue; Lin Li; Shuhai Li; Lei Qi; Wensi Hu; Cun Gao; Libo Si

    2014-01-01

    BACKGROUND: The aim of this study was to examine BRF2 expression in patients with non-small cell lung cancer (NSCLC) and explore the relationship of BRF2 protein with clinicopathologic factors, tumor angiogenesis and prognosis. METHODS: Both BRF2 protein and intratumoral microvessels were examined by immunohistochemical staining in 107 non-small cell lung cancer patients. Intratumoral microvessel density (MVD) was measured by counting CD-34 positive immunostained endothelial cells. Western bl...

  20. Analysis on influential factors of prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

    Institute of Scientific and Technical Information of China (English)

    张宇晨

    2013-01-01

    Objective To explore the gender difference of prognosis in patients with ST-segment elevation myocardial infarction(STEMI) undergoing primary percutaneous coronary intervention(pPCI). Methods Between April 2003 and March 2009,743 patients undergoing pPCI in Beijing

  1. 突发性耳聋预后相关因素分析%Analysis of the related factors of sudden deafness prognosis

    Institute of Scientific and Technical Information of China (English)

    毕永华

    2014-01-01

    目的:探讨突发性耳聋预后的相关因素,为诊断及治疗该病提供有效的临床依据。方法:2011年1月-2013年12月收治突发性耳聋患者103例,对其临床资料进行回顾性分析。选取多项与突发性耳聋预后可能相关的因素进行统计分析,评价各相关因素对预后的影响。结果:性别、年龄、患侧耳与预后无明显相关性(P>0.05);发病后开始治疗时间、发病时听力下降程度、是否早期使用激素等与预后有明显相关性(P<0.05)。结论:发病后早期治疗及早期使用激素有助于患者听力恢复;患者听力的下降程度越大,预后就越差。%Objective:To explore the related factors of sudden deafness prognosis,and to provide effective clinical basis for the diagnosis and treatment of the disease.Methods:103 cases with sudden deafness were selected from January 2011 to December 2013.Their clinical data were retrospectively analyzed.Selecting many maybe related factors of sudden deafness prognosis were given statistical analysis.The effects of related factors on the prognosis were evaluated.Results:Gender,age,sick ear had no significant correlation with prognosis(P>0.05).The start treatment time after the onset,the hearing loss degree when the onset, whether early using hormones had significant correlation with prognosis(P<0.05).Conclusion:Early treatment and early using hormone after the onset help hearing restored of patients.The hearing decreased degree of patients with is bigger,and the prognosis is worse.

  2. Intellectual disability: definition, etiological factors, classification, diagnosis, treatment and prognosis Discapacidad intelectual: definición, factores etiológicos, clasificación, diagnóstico, tratamiento y prognosis

    Directory of Open Access Journals (Sweden)

    Gregorio Katz

    2008-01-01

    Full Text Available Etiology and classification: Causal factors related with cognitive disability are multiples and can be classified as follows: Genetic, acquired (congenital and developmental, environmental and sociocultural. Likewise, in relation to the classification, cognitive disability has as a common denominator a subnormal intellectual functioning level; nevertheless, the extent to which an individual is unable to face the demands established by society for the individual’s age group has brought about four degrees of severity: Mild, moderate, severe and profound. Diagnostic: The clinical history must put an emphasis on healthcare during the prenatal, perinatal and postnatal period and include the results of all previous studies, including a genealogical tree for at least three generations and an intentional search for family antecedents of mental delay, psychiatric illnesses and congenital abnormalities. The physical exam should focus on secondary abnormalities and congenital malformations, somatometric measurements and neurological and behavioral phenotype evaluations. If it is not feasible to establish a clinical diagnosis, it is necessary to conduct high-resolution cytogenetic studies in addition to metabolic clinical evaluations. In the next step, if no abnormal data are identified, submicroscopic chromosomal disorders are evaluated. Prognosis: Intellectual disability is not curable; and yet, the prognostic in general terms is good when using the emotional wellbeing of the individual as a parameter. Conclusions: Intellectual disability should be treated in a comprehensive manner. Nevertheless, currently, the fundamental task and perhaps the only one that applies is the detection of the limitation and abilities as a function of subjects’ age and expectations for the future, with the only goal being to provide the support necessary for each one of the dimensions or areas in which the person’s life is expressed and exposed.Etiología y clasificaci

  3. The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer.

    LENUS (Irish Health Repository)

    d'Adhemar, Charles J

    2014-01-01

    The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistance. This study aims to provide further evidence that MyD88 positive cancer cells are clinically significant, stem-like and reproducibly detectable for the purposes of prognostic stratification. Expression of TLR4 and MyD88 was assessed immunohistochemically in 198 paraffin-embedded ovarian tissues and in an embryonal carcinoma model of cancer stemness. In parallel, expression of TLR4 and MyD88 mRNA and regulatory microRNAs (miR-21 and miR-146a) was assessed, as well as in a series of chemosensitive and resistant cancer cells lines. Functional analysis of the pathway was assessed in chemoresistant SKOV-3 ovarian cancer cells. TLR4 and MyD88 expression can be reproducibly assessed via immunohistochemistry using a semi-quantitative scoring system. TLR4 expression was present in all ovarian epithelium (normal and neoplastic), whereas MyD88 was restricted to neoplastic cells, independent of tumour grade and associated with reduced progression-free and overall survival, in an immunohistological specific subset of serous carcinomas, p<0.05. MiR-21 and miR-146a expression was significantly increased in MyD88 negative cancers (p<0.05), indicating their participation in regulation. Significant alterations in MyD88 mRNA expression were observed between chemosensitive and chemoresistant cells and tissue. Knockdown of TLR4 in SKOV-3 ovarian cells recovered chemosensitivity. Knockdown of MyD88 alone did not. MyD88 expression was down-regulated in differentiated embryonal carcinoma (NTera2) cells, supporting the MyD88+ cancer stem cell hypothesis. Our findings demonstrate that expression of MyD88 is associated with significantly reduced patient survival and altered microRNA levels and suggest an intact\\/functioning TLR4\\/MyD88

  4. Impact of early psychosocial factors (childhood socioeconomic factors and adversities on future risk of type 2 diabetes, metabolic disturbances and obesity: a systematic review

    Directory of Open Access Journals (Sweden)

    Tamayo Teresa

    2010-09-01

    Full Text Available Abstract Background Psychological factors and socioeconomic status (SES have a notable impact on health disparities, including type 2 diabetes risk. However, the link between childhood psychosocial factors, such as childhood adversities or parental SES, and metabolic disturbances is less well established. In addition, the lifetime perspective including adult socioeconomic factors remains of further interest. We carried out a systematic review with the main question if there is evidence in population- or community-based studies that childhood adversities (like neglect, traumata and deprivation have considerable impact on type 2 diabetes incidence and other metabolic disturbances. Also, parental SES was included in the search as risk factor for both, diabetes and adverse childhood experiences. Finally, we assumed that obesity might be a mediator for the association of childhood adversities with diabetes incidence. Therefore, we carried out a second review on obesity, applying a similar search strategy. Methods Two systematic reviews were carried out. Longitudinal, population- or community-based studies were included if they contained data on psychosocial factors in childhood and either diabetes incidence or obesity risk. Results We included ten studies comprising a total of 200,381 individuals. Eight out of ten studies indicated that low parental status was associated with type 2 diabetes incidence or the development of metabolic abnormalities. Adjustment for adult SES and obesity tended to attenuate the childhood SES-attributable risk but the association remained. For obesity, eleven studies were included with a total sample size of 70,420 participants. Four out of eleven studies observed an independent association of low childhood SES on the risk for overweight and obesity later in life. Conclusions Taken together, there is evidence that childhood SES is associated with type 2 diabetes and obesity in later life. The database on the role of

  5. Profile of Patients with Acute Poisoning and Factors Effecting Prognosis: A Retrospective Analysis in the Intensive Care

    OpenAIRE

    Mehmet Toptaş; İbrahim Akkoç; Ramazan Kaya; Sinan Uzman; Yaşar Gökhan Gül; Yadigar Yılmaz; Hayrettin Daşkaya; Ferda Yılmaz İnal

    2014-01-01

    Aim: The aim of this study was to retrospectively analyse demographic and epidemiologic characteristics, clinical course, laboratory results and prognosis of patients who were admitted to Haseki Training and Research Hospital Intensive Care Unit due to intoxication between 24.11 2007 and 21.02.2013. Methods: We evaluated age, gender, types of intoxication (accident, suicide), etiology, length of stay, mortality rate, duration of mechanical ventilation, and blood pressure, heart rate and sy...

  6. Incidence and Risk Factors of Serious Adverse Events during Antituberculous Treatment in Rwanda: A Prospective Cohort Study

    Science.gov (United States)

    Lorent, Natalie; Sebatunzi, Osee; Mukeshimana, Gloria; Van den Ende, Jef; Clerinx, Joannes

    2011-01-01

    Background Tuberculosis (TB) and TB-human immunodeficiency virus infection (HIV) coinfection is a major public health concern in resource-limited settings. Although TB treatment is challenging in HIV-infected patients because of treatment interactions, immunopathological reactions, and concurrent infections, few prospective studies have addressed this in sub-Saharan Africa. In this study we aimed to determine incidence, causes of, and risk factors for serious adverse events among patients on first-line antituberculous treatment, as well as its impact on antituberculous treatment outcome. Methods and findings Prospective observational cohort study of adults treated for TB at the Internal Medicine department of the Kigali University Hospital from May 2008 through August 2009. Of 263 patients enrolled, 253 were retained for analysis: median age 35 (Interquartile range, IQR 28–40), 55% male, 66% HIV-positive with a median CD4 count 104 cells/mm3 (IQR 44–248 cells/mm3). Forty percent had pulmonary TB, 43% extrapulmonary TB and 17% a mixed form. Sixty-four (26%) developed a serious adverse event; 58/167 (35%) HIV-infected vs. 6/86 (7%) HIV-uninfected individuals. Commonest events were concurrent infection (n = 32), drug-induced hepatitis (n = 24) and paradoxical reactions/TB-IRIS (n = 23). HIV-infection (adjusted Hazard Ratio, aHR 3.4, 95% Confidence Interval, CI 1.4–8.7) and extrapulmonary TB (aHR 2, 95%CI 1.1–3.7) were associated with an increased risk of serious adverse events. For TB/HIV co-infected patients, extrapulmonary TB (aHR 2.0, 95%CI 1.1–3.9) and CD4 count <100 cells/mm3 at TB diagnosis (aHR 1.7, 95%CI 1.0–2.9) were independent predictors. Adverse events were associated with an almost two-fold higher risk of unsuccessful treatment outcome at 6 months (HR 1.89, 95%CI 1.3–3.0). Conclusion Adverse events frequently complicate the course of antituberculous treatment and worsen treatment outcome, particularly in patients with

  7. Incidence and risk factors of serious adverse events during antituberculous treatment in Rwanda: a prospective cohort study.

    Directory of Open Access Journals (Sweden)

    Natalie Lorent

    Full Text Available BACKGROUND: Tuberculosis (TB and TB-human immunodeficiency virus infection (HIV coinfection is a major public health concern in resource-limited settings. Although TB treatment is challenging in HIV-infected patients because of treatment interactions, immunopathological reactions, and concurrent infections, few prospective studies have addressed this in sub-Saharan Africa. In this study we aimed to determine incidence, causes of, and risk factors for serious adverse events among patients on first-line antituberculous treatment, as well as its impact on antituberculous treatment outcome. METHODS AND FINDINGS: Prospective observational cohort study of adults treated for TB at the Internal Medicine department of the Kigali University Hospital from May 2008 through August 2009. Of 263 patients enrolled, 253 were retained for analysis: median age 35 (Interquartile range, IQR 28-40, 55% male, 66% HIV-positive with a median CD4 count 104 cells/mm(3 (IQR 44-248 cells/mm(3. Forty percent had pulmonary TB, 43% extrapulmonary TB and 17% a mixed form. Sixty-four (26% developed a serious adverse event; 58/167 (35% HIV-infected vs. 6/86 (7% HIV-uninfected individuals. Commonest events were concurrent infection (n = 32, drug-induced hepatitis (n = 24 and paradoxical reactions/TB-IRIS (n = 23. HIV-infection (adjusted Hazard Ratio, aHR 3.4, 95% Confidence Interval, CI 1.4-8.7 and extrapulmonary TB (aHR 2, 95%CI 1.1-3.7 were associated with an increased risk of serious adverse events. For TB/HIV co-infected patients, extrapulmonary TB (aHR 2.0, 95%CI 1.1-3.9 and CD4 count <100 cells/mm3 at TB diagnosis (aHR 1.7, 95%CI 1.0-2.9 were independent predictors. Adverse events were associated with an almost two-fold higher risk of unsuccessful treatment outcome at 6 months (HR 1.89, 95%CI 1.3-3.0. CONCLUSION: Adverse events frequently complicate the course of antituberculous treatment and worsen treatment outcome, particularly in patients with extrapulmonary

  8. Factors associated with crashes involving taxi owners and non-owners: A case of moral hazard and adverse selection?

    Science.gov (United States)

    Tay, Richard; Choi, Jaisung

    2016-02-01

    Taxis experience a higher risk of a motor vehicle crash partly because of their much higher levels of exposure on the roads. Although several studies have been conducted to examine the factors associated with the frequency and severity of taxi collisions, little research has been conducted to examine the differences in the factors associated with owner taxis and non-owner taxis. This study finds that collisions involving non-owners are more likely to be associated with poor or risky driving behaviors than collisions involving taxi vehicle owners. This result is consistent with the economic principles of moral hazard and adverse selection. Hence, policy makers responsible for traffic safety, taxi regulation or taxi operations should consider measures to reduce these market inefficiencies and improve the safety of not only taxi drivers but all road users. PMID:26655521

  9. Adverse Factors in the Development of an Open University in Latin America.

    Science.gov (United States)

    Escotet, Miguel Angel

    1980-01-01

    Discusses variables such as financial resources, political determinants, resistance to innovation, learning styles, student population, organizational and institutional structures, human resources, and communication, as possible factors which detain adequate development of the open university in Latin America. Nineteen references are listed.…

  10. Xenobiotic sulphation and its variability during inflammation: a factor in adverse drug reactions?

    Science.gov (United States)

    Waring, R H; Harris, R M; Hunter, J O; Mitchell, S C

    2013-03-01

    The interactions between disease processes and the metabolism of therapeutic drugs have not been systematically investigated. Inflammation, with the presence of pro-inflammatory cytokines, affects Phase 1 metabolism, particularly the activity of the CYP isoforms. Inflammatory factors also alter the activity of some Phase 2 enzymes, particularly the sulphotransferases (SULT isoforms) responsible for drug sulphonation and the enzyme pathway involved in the supply of sulphate for this reaction. Being ill may, therefore, in itself make drug metabolism unpredictable. PMID:23176089

  11. Depression as a risk factor for adverse outcomes in coronary heart disease

    OpenAIRE

    Freedland, Kenneth E.; Carney, Robert M.

    2013-01-01

    Background Depression is firmly established as an independent predictor of mortality and cardiac morbidity in patients with coronary heart disease (CHD). However, it has been difficult to determine whether it is a causal risk factor, and whether treatment of depression can improve cardiac outcomes. In addition, research on biobehavioral mechanisms has not yet produced a definitive causal model of the relationship between depression and cardiac outcomes. Discussion Key challenges in this line ...

  12. Risk factors of adverse drug reaction from non-steroidal anti-inflammatory drugs in Shanghai patients with arthropathy

    Institute of Scientific and Technical Information of China (English)

    Wen SHI; Yong-ming WANG; Shao-li LI; Min YAN; Duan Li; Bin-yah CHEN; Neng-neng CHENG

    2004-01-01

    AIM: The study was to screen the possible risk factors of adverse drug reaction (ADR) induced by non-steroidal anti-inflammatory drugs (NSAIDs) in Shanghai patients with arthropathy. METHODS: The subjects were randomly selected from a database of outpatients with arthropathy from 9 main hospitals in Shanghai. A door to door retrospective epidemiological survey was used to collect demographic information about the patients, both individual and familial. This included data on their medical histories, lifestyle and dietary habits, history of smoking and alcohol consumption, history of drug therapy, quality of life (QOL) prior to NSAIDs intake, history of NSAIDs therapy and its ADR events, etc. Descriptive statistical methods and univariate analysis were also used to identify possible risk factors for ADRs induced by NSAIDs. RESULTS: Of the 1002 patients surveyed, the average length of NSAIDs intake was 2 years. ADR incidence from different NSAIDs was high, in a range from 46.7 %-66.2 %.In general, the candidate risk factors for ADRs were different for each NSAID. Each of the candidate risk factors were defined and studied in order to evaluate its role in the determination of ADRs from NSAIDs. "Family history of ADRs caused by NSAIDs" was found to be a significant risk factor for the four commonly used NSAIDs:meloxicam, diclofenac, nimesulide, and nabumetone. CONCLUSION: A retrospective epidemiological survey was useful in detecting the risk factors for ADRs caused by NSAIDs. The study found that different NSAIDs might have different risk factors and that there is no single risk factor universally applicable to all NSAIDs.

  13. Adolescence as risk factor for adverse pregnancy outcome in Central Africa--a cross-sectional study.

    Directory of Open Access Journals (Sweden)

    Florian Kurth

    Full Text Available BACKGROUND: Sub-Saharan Africa has the highest rates of maternal and neonatal mortality worldwide. Young maternal age at delivery has been proposed as risk factor for adverse pregnancy outcome, yet there is insufficient data from Sub-Saharan Africa. The present study aimed to investigate the influence of maternal adolescence on pregnancy outcomes in the Central African country Gabon. METHODOLOGY AND PRINCIPAL FINDINGS: Data on maternal age, parity, birth weight, gestational age, maternal Plasmodium falciparum infection, use of bednets, and intake of intermittent preventive treatment of malaria in pregnancy were collected in a cross-sectional survey in 775 women giving birth in three mother-child health centers in Gabon. Adolescent women (≤16 years of age had a significantly increased risk to deliver a baby with low birth weight in univariable analysis (22.8%, 13/57, vs. 9.3%, 67/718, OR: 2.9, 95% CI: 1.5-5.6 and young maternal age showed a statistically significant association with the risk for low birth weight in multivariable regression analysis after correction for established risk factors (OR: 2.7; 95% CI: 1.1-6.5. In further analysis adolescent women were shown to attend significantly less antenatal care visits than adult mothers (3.3±1.9 versus 4.4±1.9 mean visits, p<0.01, n = 356 and this difference accounted at least for part of the excess risk for low birth weight in adolescents. CONCLUSION: Our data demonstrate the importance of adolescent age as risk factor for adverse pregnancy outcome. Antenatal care programs specifically tailored for the needs of adolescents may be necessary to improve the frequency of antenatal care visits and pregnancy outcomes in this risk group in Central Africa.

  14. Early Life Adversity as a Risk Factor for Fibromyalgia in Later Life

    Directory of Open Access Journals (Sweden)

    Lucie A. Low

    2012-01-01

    Full Text Available The impact of early life events is increasingly becoming apparent, as studies investigate how early childhood can shape long-term physiology and behaviour. Fibromyalgia (FM, which is characterised by increased pain sensitivity and a number of affective co-morbidities, has an unclear etiology. This paper discusses risk factors from early life that may increase the occurrence or severity of FM in later life: pain experience during neonatal life causes long-lasting changes in nociceptive circuitry and increases pain sensitivity in the older organism; premature birth and related stressor exposure cause lasting changes in stress responsivity; maternal deprivation affects anxiety-like behaviours that may be partially mediated by epigenetic modulation of the genome—all these adult phenotypes are strikingly similar to symptoms displayed by FM sufferers. In addition, childhood trauma and exposure to substances of abuse may cause lasting changes in developing neurotransmitter and endocrine circuits that are linked to anxiety and stress responses.

  15. Relationship between serum carcinoembryonic antigen level and epidermal growth factor receptor mutations with the influence on the prognosis of non-small-cell lung cancer patients

    Directory of Open Access Journals (Sweden)

    Cai ZX

    2016-06-01

    Full Text Available Zuxun Cai Department of Thoracic Surgery, Henan Provincial Chest Hospital, Zhengzhou City, People’s Republic of China Objective: To investigate the relationship between serum carcinoembryonic antigen (CEA level and epidermal growth factor receptor (EGFR gene mutations in non-small-cell lung cancer (NSCLC patients and to analyze the influence of CEA level on postoperative survival time in lung cancer patients. Methods: A total of 296 patients who were treated in Thoracic Surgery Department of Henan Provincial Chest Hospital from September 2011 to September 2013 were recruited. The level of tumor markers, such as CEA, was determined before the surgery, and EGFR gene mutations were detected after surgery. Thereby, the relationship between tumor makers, including CEA, and EGFR mutation and its influence on prognosis could be investigated. Results: Among 296 patients, the positive rate of EGFR gene mutation was 37.84% (112/296; the mutation occurred more frequently in nonsmokers, adenocarcinoma patients, women, and patients aged <60 years (P<0.05. Both tumor markers and chemosensitivity indicators were related to the profile of EGFR mutations. Elevated squamous cell carcinoma and Cyfra21-1 as well as positively expressed ERCC1 were more common in patients with wild-type EGFR (P<0.05, whereas increased CEA level was observed more frequently in patients with EGFR gene mutation (P=0.012. The positive rate of EGFR gene mutations was higher as the serum CEA level increased, that is, the positive rate in patients with serum CEA level <5, 5–20, and >20 µg/L was 39.81%, 45.32%, and 65.47%, respectively (P=0.004. Logistic regression analysis showed that CEA level was an independent factor in predicting EGFR gene mutations, and serum CEA level was also an independent factor in affecting the prognosis of NSCLC patients, as the overall 2-year survival rate was 73.86% in elevated CEA group and 86.43% in normal group (P<0.01. Conclusion: The prognosis of

  16. Atopic diseases: Risk factor in developing adverse reaction to intravenous N-Acetylcysteine

    Directory of Open Access Journals (Sweden)

    F Gheshlaghi

    2006-05-01

    Full Text Available Background: N-acetylcysteine (NAC is the choice treatment for acetaminophen overdose. The main side effect of intravenous NAC therapy is anaphylaxis or anaphylactoid reactions. We investigated the prevalence of anaphylactoid or anaphylaxis reactions to IV-NAC therapy in acetaminophen poisoned patients with atopic disease. Methods: A case series antrograde and descriptive–analytic study was done on acetaminophen poisoned patients who treated with IV-NAC from September 2003 to September 2004 in Isfahan, Iran. Results: Of 173 infused IV-NAC patients, 77 patients (44.5% developed an anaphylactoid reaction. Its side effects was nausea and vomiting (n=49, 63.15%, flashing (n=23, 30.26%, bronchospasm (n=20, 26.31%, vertigo (n=18, 23.68%, skin rash (n=25, 32.36% and hypotension (n=12, 15.75%. Also, 71 patients (41% had history of atopic disease. Atopic diseases were asthma (n=12, 6.9%, atopic dermatitis (n=7, 4%, allergic rhinitis (n=5, 2.8% and allergic conjunctivitis (n=1, 0.5%. Among 71 atopic patients, 59 patients (83.13 % developed side effects to NAC. There was a relation between previous history of atopic disease and anaphylactoid reaction to NAC. Conclusions: We report substantially higher incidence of anaphylactoid reactions to IV-NAC than previous studies. Different atopic diseases must be considered as a risk factor in the development of side effects to IV-NAC-therapy. Keywords: Poisoning, Acetaminophen, Anaphylactoid reaction, N-acetylcysteine, Atopic disease

  17. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Prognosis Questions to Ask about Your Diagnosis Research Understanding Cancer Prognosis Oncologist Anthony L. Back, M.D., ... find our information on Coping With Cancer helpful. Understanding Statistics About Survival Doctors estimate prognosis by using ...

  18. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... disease will go for you is called prognosis. It can be hard to understand what prognosis means ... prognosis include: The type of cancer and where it is in your body The stage of the ...

  19. Amplification of chromosome 2:Lq22.3 harboring trefoil factor family genes in liver fluke related cholangiocarcinoma is associated with poor prognosis

    Institute of Scientific and Technical Information of China (English)

    Kanuengnuch Muenphon; Temduang Limpaiboon; Patcharee Jearanaikoon; Chawalit Pairojkul; Banchob Sripa; Vajarabhongsa Bhudhisawasdi

    2006-01-01

    AIM: To determine allelic imbalance on chromosomal region 21q22-qter including trefoil factor family genes (TFF) in cholangiocarcinoma (CCA) patients and analyze the correlation between allelic imbalances and clinicopathological parameters.METHODS: Quantitative PCR amplification was performed on four microsatellite markers and trefoil factor family genes (TFF1, TFF2, and TFF3) using a standard curve and SYBR Green Ⅰ dye method. The relative copy number was determined by DNA copy number of tested locus to reference locus. The relative copy number was interpreted as deletion or amplification by comparison with normal reference range. Associations between allelic imbalance and clinicopathological parameters of CCA patients were evaluated by x2-tests.Kaplan-Meier method was used to analyze survival.RESULTS: The frequencies of amplification at D21S1890,D21S1893, and TFF3 were 32.5%, 30.0%, and 28.7%,respectively. Patients who had amplification at regions covering D21S1893, D21S1890, and TFF showed poor prognosis, whereas patients who had deletion showed favorable prognosis (mean: 51.7 wk vs 124.82 wk,P = 0.012). Multivariate Cox regression analysis revealed that amplification of D21S1893, D21S1890 and TFF,blood vessel invasion, and staging were associated with poor prognosis.CONCLUSION: D21S1893-D21S1890 region may harbor candidate genes especially TFF and serine protease family, which might be involved in tumor invasion and metastasis contributing to poor survival. The amplification in this region may be used as a prognostic marker in the treatment of CCA patients.

  20. Expressions of CLDN1 and insulin-like growth factor 2 are associated with poor prognosis in stage N2 non-small cell lung cancer

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhen-fa; PEI Bao-xiang; WANG An-lei; ZHANG Lian-min; SUN Bing-sheng; JIANG Ri-cheng; WANG Chang-li

    2013-01-01

    Background Patients with single station mediastinal lymph node (N2) non-small call lung ccancer (NSCLC) have a better prognosis than those with multilevel N2.The molecular factors which are involved in disease progression remain largely unknown.The purpose of this study was to investigate gene expression differences between single station and multilevel N2 NSCLC and to identify the crucial molecular factors which are associated with progress and prognosis of stage N2 NSCLC.Methods Gene expression analysis was performed using Agilent 4x44K Whole Human Genome Oligo Microarray on 10 freshfrozen lymph node tissue samples from single station N2 and paired multilevel N2 NSCLC patients.Real-time reverse transcription (RT)-PCR was used to validate the differential expression of 14 genes selected by cDNA microarray of which four were confirmed.Immunohistochemical staining for these validated genes was performed on formalin-fixed,paraffinembedded tissue samples from 130 cases of stage N2 NSCLC arranged in a high-density tissue microarray.Results We identified a 14 gene expression signature by comparative analysis of gene expression.Expression of these genes strongly differed between single station and multilevel N2 NSCLC.Four genes (ADAM28,MUC4,CLDN1,and IGF2) correlated with the results of microarray and real-time RT-PCR analysis for the gene-expression data in samples from 56 NSCLC patients.Immunohistochemical staining for these genes in samples from 130 cases of stage N2 NSCLC demonstrated the expression of IGF2 and CLDN1 was negatively correlated with overall survival of stage N2 NSCLC.Conclusions Our results suggest that the expression of CLDN1 and IGF2 indicate a poor prognosis in stage N2 NSCLC.Further,CLDN1 and IGF2 may provide potential targeting opportunities in future therapies.

  1. Percutaneous transluminal angioplasty of malfunctioning Brescia-Cimino arteriovenous fistula: analysis of factors adversely affecting long-term patency

    Energy Technology Data Exchange (ETDEWEB)

    Sugimoto, Koji; Hirota, Shozo; Sugimura, Kazuro [Department of Radiology, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-Ku, 650-0017, Kobe (Japan); Higashino, Takanori; Kuwata, Yoichiro; Imanaka, Kazufumi [Department of Radiology, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, 651-2273, Kobe (Japan)

    2003-07-01

    Our objective was to identify the factors adversely affecting long-term patency after percutaneous transluminal angioplasty (PTA) for hemodialysis Brescia-Cimino arteriovenous fistulas. Between November 1995 and March 2000, 91 PTA procedures were performed on 50 patients with 57 Brescia-Cimino fistulas. A retrospective study based on the chart review was performed. The initial technical success rate for all procedures and the primary and secondary patency rates for all fistulas were calculated. Regarding fistulas successfully maintained by the primary PTA, the primary and secondary patency rates were compared using the Kaplan-Meier method between two patient groups. They were classified on the basis of several factors, including age (older, over 70 years, and younger group), age of the fistulas (older, over 6 months, and younger group), with or without diabetes mellitus (DM), solitary or multiple lesions, long or short segment lesion, stenosis or occlusion, and with or without arterial and/or anastomotic lesions. Initial technical success rates for all procedures and fistulas were 91.2 and 89.5%, respectively. Cumulative primary and secondary patency rates at 1 year were 47.3 and 67.3%, respectively. In the comparative study, the secondary patency rate for the older group was lower than that of the younger group with statistical significance (p =0.029). The higher age is the only factor that reduces the long-term patency rate after PTA. (orig.)

  2. Percutaneous transluminal angioplasty of malfunctioning Brescia-Cimino arteriovenous fistula: analysis of factors adversely affecting long-term patency

    International Nuclear Information System (INIS)

    Our objective was to identify the factors adversely affecting long-term patency after percutaneous transluminal angioplasty (PTA) for hemodialysis Brescia-Cimino arteriovenous fistulas. Between November 1995 and March 2000, 91 PTA procedures were performed on 50 patients with 57 Brescia-Cimino fistulas. A retrospective study based on the chart review was performed. The initial technical success rate for all procedures and the primary and secondary patency rates for all fistulas were calculated. Regarding fistulas successfully maintained by the primary PTA, the primary and secondary patency rates were compared using the Kaplan-Meier method between two patient groups. They were classified on the basis of several factors, including age (older, over 70 years, and younger group), age of the fistulas (older, over 6 months, and younger group), with or without diabetes mellitus (DM), solitary or multiple lesions, long or short segment lesion, stenosis or occlusion, and with or without arterial and/or anastomotic lesions. Initial technical success rates for all procedures and fistulas were 91.2 and 89.5%, respectively. Cumulative primary and secondary patency rates at 1 year were 47.3 and 67.3%, respectively. In the comparative study, the secondary patency rate for the older group was lower than that of the younger group with statistical significance (p =0.029). The higher age is the only factor that reduces the long-term patency rate after PTA. (orig.)

  3. Urinary Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) • Insulin-Like Growth Factor-Binding Protein 7 (IGFBP7) Predicts Adverse Outcome in Pediatric Acute Kidney Injury

    OpenAIRE

    Westhoff, Jens H.; Tönshoff, Burkhard; Waldherr, Sina; Pöschl, Johannes; Teufel, Ulrike; Westhoff, Timm H.; Fichtner, Alexander

    2015-01-01

    Background The G1 cell cycle inhibitors tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been identified as promising biomarkers for the prediction of adverse outcomes including renal replacement therapy (RRT) and mortality in critically ill adult patients who develop acute kidney injury (AKI). However, the prognostic value of urinary TIMP-2 and IGFBP7 in neonatal and pediatric AKI for adverse outcome has not been investigated yet...

  4. Role of DNA damage and repair as predeterminant factor in the development of radiotherapy induced acute adverse reactions

    International Nuclear Information System (INIS)

    Radiotherapy induced normal tissue toxicity is one of the major limitations for the compromised the therapeutic outcome and also worsens the quality of life of survivors. Further, the clinical experience demonstrated inter-individual variability with respect to their normal tissue toxicity. Therefore, the discovery of contributing key factors of variability or predicting the risk of developing acute reactions before the initiation of radiation therapy may serve as a powerful predictive biomarker for individualizing radiotherapy, anticipating increased therapeutic effect. DNA double-strand break (DSB) induction and its repair in lymphocytes of head-and-neck and breast cancer patients undergoing chemoradiation or radiation therapy alone were analyzed by performing γ-H2AX foci, neutral comet and a modified neutral filter elution assays. Treatment induced normal tissue adverse reactions (acute skin reaction, oral mucositis) were assessed by the criteria of Radiation Therapy Oncology Group. The residual damage (RD) at 6 hrs of post irradiation was used as parameters to measure cellular radiosensitivity and for its correlation with radiotherapy induced acute reactions in patients stratified as non-over responders (NOR) and over responders (OR). A large inter-individual variation in the radiosensitivity was observed in the cancer individuals with respect to their lymphocyte radiosensitivity and the severity of normal tissue adverse reactions. There was a significant difference in RD (p<0.05) between the NOR and OR in breast cancer radiotherapy. Further, the increased normal tissue toxicity such as oral mucositis and skin reactions was associated with the reduced DSB repair (p<0.05) in head-and-neck cancer patients. The percentile analysis was found to be useful in predicting the OR amongst the head-and-neck cancer patients. Our results suggest that γ-H2AX analysis may have its potential to be developed into a clinically useful predictive assay for identifying the

  5. Human factors issues for resolving adverse effects of human work underload and workload transitions in complex human-machine systems

    International Nuclear Information System (INIS)

    A workshop was conducted whose specific purpose was to build on earlier work of the United States National Research Council, United States Federal government agencies, and the larger human factors community to: (1) clarify human factors issues pertaining to degraded performance in advanced human-machine systems (e.g., nuclear production, transportation, aerospace) due to human work underload and workload transition, and (2) develop strategies for resolving these issues. Recent history demonstrates that: (1) humans often react adversely to their diminishing roles in advanced human-machine systems, and therefore (2) new allocation models and strategies are required if humans are to be willing and able to assume diminishing and shifting roles assigned to them in these systems, and are to accept new technologies making up these systems. Problems associated with theses diminishing and shifting human roles are characterized as work underload and workload transitions. The workshop affirmed that: (1) work underload and workload transition are issues that will have to be addressed by designers of advanced human-machine systems, especially those relying on automation, if cost, performance, safety, and operator acceptability are to be optimized, (2) human machine allocation models, standards, and guidelines which go beyond simple capability approaches will be needed to preclude or seriously diminish the work underload and workload transition problems, and (3) the 16 workload definition, measurement, situational awareness, and trust issues identified during the workshop, need resolution if these models, standards, and guidelines are to be achieved. (author)

  6. Intervillous macrophage migration inhibitory factor is associated with adverse birth outcomes in a study population in Central India.

    Directory of Open Access Journals (Sweden)

    Puspendra P Singh

    Full Text Available Macrophage migration inhibitory factor (MIF is a pluripotent factor produced by a variety of cells. It plays an important biological role in the regulation of pregnancy and has been shown to influence malaria pathogenesis. In this study, the levels of MIF in the peripheral, cord and placental intervillous blood (IVB plasma collected from women residing in a malaria endemic region of Central India was determined and its association with malaria in pregnancy and birth outcomes was investigated. MIF levels were significantly different in IVB, peripheral, and cord plasma, with IVB plasma having the highest MIF levels and peripheral plasma having the lowest. Placental malaria positive women had significantly higher IVB plasma MIF levels than placental malaria negative women, but this relationship was not seen in peripheral or cord plasma MIF levels. In addition, the odds of stillbirth and low birth weight deliveries for the uppermost placental MIF quartile (irrespective of placental malaria status was significantly higher than that of the lowest placental MIF quartile, supporting the hypothesis that elevated concentrations of placental MIF may be associated with an increased risk of adverse birth outcome.

  7. PRISMA-Compliant Article: Clinical Characteristics and Factors Influencing Prognosis of Patients With Hepatoid Adenocarcinoma of the Stomach in China.

    Science.gov (United States)

    Qu, Bao-Ge; Bi, Wei-Min; Qu, Bao-Teng; Qu, Tao; Han, Xing-Hai; Wang, Hui; Liu, Yuan-Xun; Jia, Yi-Guo

    2016-04-01

    Most previous studies have been single case reports, and studies with large samples are presently lacking. In addition, no studies have investigated the associations between the clinical characteristics and prognosis of hepatoid adenocarcinoma of the stomach (HAS).The aim of this study was to explore the associations of different clinical characteristics with the ages, serum alpha-fetoprotein (AFP) levels, and survival times of HAS patients.The present study was conducted using the CBM disc, HowNet, Wanfang and VIP data resource systems, and PubMed. According to the PRISMA Flow Diagram, certain case reports from the same center, those that did not provide patient age or sex, and those that did not report serum AFP levels or AFP immunohistochemistry results were excluded. A total of 131 relevant articles, including 124 case reports, 5 reviews, and 2 postgraduate Master's theses, were reported in the above-mentioned five databases. We applied inclusion criteria to case reports on the clinical characteristics and prognosis of HAS, which resulted in the ultimate inclusion of 180 patients from 62 case reports for statistical analyses.The main finding was that the age of the men was significantly higher than that of the women (P = 0.004). In addition, the serum AFP levels of the participants with antral disease were significantly higher than those with nonantral disease (P = 0.001). The median serum AFP levels and survival times significantly differed among the patients with the three lesion types (P = 0.001 and 0.019, respectively). The serum AFP levels of the participants with ulcerative-upheaval-type tumors and purely ulcerative tumors were significantly higher than those with upheaval-type tumors (P = 0.000 and 0.017, respectively). In addition, the serum AFP levels of the participants with ulcerative-upheaval-type tumors were significantly higher than those with ulcerative-type tumors (P = 0.019), and their survival time was also significantly

  8. Growth hormone and insulin-like growth factor-1 in prognosis coronary artery disease in patients with obesity

    Directory of Open Access Journals (Sweden)

    Olga Viktorovna Shpagina

    2014-10-01

    Full Text Available Introduction. In patients with obesity coronary atherosclerosis and chronic heart failure (CHF progress rapidly and have a worse long-term prognosis than those with normal weight.Objective: To investigate the prognostic significance of GH and IGF-1 in the evaluation of cardiovascular risk in patients with obesity.Materials and Methods. The study included 75 men (mean age 55.31±6.32 years, which are overweight or have mild obesity (body mass index (BMI 28.69±3.6 kg/m2. Group 1 included 45 patients (age 56.4±6.29 years, BMI 28.69±3.69 kg/m2, blood pressure 124±10.18/80±4.59 mm Hg who underwent coronary angiography. Group 2 included 30 patients (mean age 53.6 ± 6.1 years, BMI 28.68±3.52 kg/m2, blood pressure 128±9/83±6.81 mm Hg, CAD who are excluded by treadmill test. The coronary artery calcium score was assessed in group 2. All participants were evaluated impaired glucose tolerance (IGT, triglycerides (TG, IGF-1 and GH, LPHD, LPLD, geometry of the heart chambers was assessed by echocardiography.Results. Patients in both groups did not differ in age, BMI, blood pressure. IGF-1 levels were not significantly different among the study groups. High circulating IGF-1 levels were frequently observed in group 1 (р=0.018. A statistically significant association of high IGF-1 observed with obesity (p=0.033, smoking (p=0.049, hypertension (p=0.002, end-diastolic dimension (p=0.045. GH was lower in group 1 compared with group 2 (p=0.046. Serum levels of GH are positively associated with EF (p=0.023 and E/A (p=0.043 and negatively associated with left atrial wall thickness (p=0.025 and coronary artery calcium score (p=0.005.Conclusion: 1. IGF-1 may be a useful indicator to assess the prognosis of CAD and CHF in patients with obesity. 2. Relative GH deficiency was more often associated with severe CAD in patients with obesity.

  9. Profile of Patients with Acute Poisoning and Factors Effecting Prognosis: A Retrospective Analysis in the Intensive Care

    Directory of Open Access Journals (Sweden)

    Mehmet Toptaş

    2014-03-01

    Full Text Available Aim: The aim of this study was to retrospectively analyse demographic and epidemiologic characteristics, clinical course, laboratory results and prognosis of patients who were admitted to Haseki Training and Research Hospital Intensive Care Unit due to intoxication between 24.11 2007 and 21.02.2013. Methods: We evaluated age, gender, types of intoxication (accident, suicide, etiology, length of stay, mortality rate, duration of mechanical ventilation, and blood pressure, heart rate and symptoms at the time of admission. Patients who took multiple drugs were recorded. Liver and kidney function tests, blood glucose, complete blood count parameters, electrolytes and arterial blood gas values at the time of admission were evaluated. Results: A total of 59 cases of intoxication were studied. 59.7% of patients were male, 42.4% were female. The mean age was 32±13 years. 86.4% of cases occurred due to suicide attempts and 13.6%, accidentally. In our study, it was found that the most common intoxication agents were paracetamol and amitriptyline, and the most common cause of death was methyl alcohol intoxication. Conclusion: Our results showed that a significant portion of the intoxication cases admitted to the intensive care unit were young adults who attempted suicide by overdosing on drugs. (The Me­di­cal Bul­le­tin of Ha­se­ki 2014; 52: 29-33

  10. PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma

    LENUS (Irish Health Repository)

    Keld, R

    2011-06-28

    Background: Transcription factors often play important roles in tumourigenesis. Members of the PEA3 subfamily of ETS-domain transcription factors fulfil such a role and have been associated with tumour metastasis in several different cancers. Moreover, the activity of the PEA3 subfamily transcription factors is potentiated by Ras-ERK pathway signalling, which is itself often deregulated in tumour cells.\\r\

  11. 多发性抽动症预后的影响因素分析%Analysis of Prognosis Influencing Factor of Children with Tourette Syndrome

    Institute of Scientific and Technical Information of China (English)

    杨丽新; 陈秀梅; 谭雅婷; 曾维嘉

    2014-01-01

    Objective To explore the related factors influencing the prognosis of children with Tourette syndrome ( TS) . Methods We collected 420 outpatient cases of TS children in the department of pediatrics of Guangdong Provincial Hospital of Traditional Chinese Medicine from January of 2007 to October of 2010 as the research objects. Using the unified survey questionnaire, we observed the influencing factors of TS prognosis such as sex, onset age, mother’s pregnancy situation, the perinatal period, partiality for food intake, family relationship, the first symptom, the severity of disease, underlying diseases, comorbidities ( such as attention deficit hyperactivity disorder, anxiety disorder, and obsessive-compulsive disorder) , family history of psychiatric or neurological diseases, trace elements levels, electroencephalogram (EEG), antistreptolycin O (ASO), course of disease, and maintenance treatment. The related factors of prognosis was analyzed with single factor and multiple factors Logistic regression analysis. Results Among the 420 cases of TS children, 396 cases were included into the final analysis, 24 were lost and the follow-up lost rate was 5.7%. The remission rate of TS was 78.3%, and the uncured rate was 21.7%. The results of preliminary screening of the influencing factors by single factor Logistic analysis showed that the related influencing factors for TS prognosis were 12, and they were course of diseases, abnormal birth history, father’s education level, mother’s education level, upbringing methods, family history of psychiatric or neurological diseases, underlying disease history, comorbidities history, abnormal ASO, the severity of disease, the frequency of disease relapse, and the medication history of western medicine (P<0.05) . And then the obtained 12 factors were analyzed by the multiple fac tors Lo gistic regression analysis, the results showed that upbringing methods, comorbidities history, the severity of disease, and the frequency of

  12. Genetic, clinical and environmental factors with a probable role for development of early radiation adverse events in cervical and endometrial cancer patients after postoperative pelvic irradiation

    International Nuclear Information System (INIS)

    The aim of this study was to investigate the factors influencing the development of early radiation adverse events in cervical and endometrial cancer patients after postoperative radiotherapy. The study included 109 patients with cervical and endometrial carcinoma after radical surgery. External beam pelvic irradiation was performed on a Co-60 machine with 'Box' technique to 50 Gy total dose in 2 Gy daily fractions. Early radiation adverse events were assessed according to Common Terminology Criteria for Adverse Events, v.3.0, for first time applied in Bulgaria by own designed questionnaire. Information on smoking habits, previous abdominal surgery, sensitivity to sunlight, family history and concomitant diseases was generated. DNA isolated from venous blood was used for genotype analysis with Polymerise Chain Reaction Fragment Length Polymorphisms (PCR-REFP). Standard statistical package and logistic regression analysis was applied for statistical evaluation. Only 2% of the patients did not developed any early radiation adverse events Majority of patients suffer grade 1 and 2 adverse events. No grade 4 and 5 events were recorded. Smoking increases the grade of gastrointestinal events and the summarized clinical radiosensitivity Sensitivity to sunlight was associated with moderate and severe skin reactions. Genetic factors influence the severity of genitourinary (XRCC1 194 (C>T), XRCC1 280 (G>A)) and skin adverse events (XRCC1 194 (C>T), XRCC1 280 (G>A)) and also the summarized clinical radiosensitivity (XRCC1 194 (C>T)). The risk factors for development of early radiation adverse events found in the present study are smoking, sensitivity to sunlight and the following SNPs XRCC1 194 (C>T), XRCC1 280 (G>A) u XRCC1 194 (C>T), XRCC1 280 (G>A).

  13. 类风湿关节炎预后相关因素分析%Analysis of correlative factors on prognosis in rheumatoid arthritis

    Institute of Scientific and Technical Information of China (English)

    林玲; 肖征宇; 黄少弼; 许杰洲

    2003-01-01

    目的对 RA患者的影像学病情进展进行随访,探讨影响类风湿关节炎 (rheumatoid arthritis, RA)预后的相关因素 ,为治疗方案的合理选择提供依据.方法对 41例使用改善病情的抗风湿药物( DMARDs)治疗的 RA患者双手相 X线进展情况进行 2- 9年随访,采用多因素 logistic回归分析性别、发病年龄、病程、起病关节、关节外表现、类风湿因子、抗核抗体、抗核周抗体、抗鼠食管角质层抗体、抗 RA33抗体、 HLA-DRB1 04等位基因等因素与 RA预后的关系.结果根据 Steinbrocker分期有无进展将 41例 RA分为两组,有进展组及无进展组的平均随访时间分别为( 4.7± 2.8)年和( 3.8± 1.5)年 , 差异无显著性 (P=0.155, 95% CI: 0.375- 2.280 ).只有 DRB1 04对 RA影像学病情进展具有显著性意义 (P=0.035, 回归系数 R=0.220, 期望值 Exp=6.753).结论 HLA-DRB1等位基因可作为估计 RA病情及预后的指标.%Aim Early diagnosis and intervention may provide the greatest benefit for reducing the deformity and disability in rheumatoid arthritis (RA), and the initial steps in the management are to make a appropriate estimate of prognosis. Consequently a follow-up study was performed to investigate the correlative factors which may impact the prognosis in RA. Methods 41 cases of RA who had received disease modifying antirheumatic drugs (DMARDs) treatment were studied. All of them had taken X-ray photographs of hands and followed up for 2- 9 years. Use multivariate logistic regression analyses to analyze the factors which may impact the prognosis in RA such as sex, onset age, disease duration, onset joint, extraarticular involvements, rheumatoid factor (RF), antinuclear antibodies (ANA), antiperinuclear factor (APF), anti-keratin antibodies (AKA), anti-RA33 antibodies and HLA-DRB1 04 alleles. Results Multivariate logistic regression analyses showed that DRB1 04 alleles were associated with the radiographic damage of RA(P=0

  14. 结核性脑膜炎近期预后的影响因素研究%Influential Factors on Short-term Prognosis of Tuberculous Meningitis

    Institute of Scientific and Technical Information of China (English)

    陈劲松; 郑建明; 岳增昌; 黄天文; 李康增

    2011-01-01

    Objective To assess the short - term prognosis in patients with tuberculous meningitis ( TBM ) and its influential factors. Methods The outcomes of improvement on discharge, or deterioration/death were taken as the index to analyze general clinical data, the parameters of laboratory and nuero - imaging examinations of the 105 TBM patients. And univariate and binary multivariate Logistic regression analyses were taken to determine the influential factors to prognosis of the patients. Results The univariate analysis showed that there were statistically significant differences between the improved group and deteriorated/ death group in conscious level, blood white - cell count, and radiographic evidence of brain swelling ( P < 0. 05 ). The multivariate Logistic regression analysis showed that the decreased chloride levels of cerebrospinal fluid and decreased level of consciousness on admission were independently associated with the short - term poor outcome. Conclusion The patients with tuberculous meningitis who have decreased chloride levels of cerebrospinal fluid and decreased level of consciousness have poorer clinical prognosis.%目的 探讨结核性脑膜炎患者近期预后的影响因素.方法 以患者出院时好转或恶化/死亡为转归指标,对105例结核性脑膜炎患者的一般临床资料、实验室检查、神经影像学检查等因素进行分析.通过单因素分析和二分类多因素Logistic回归分析,确定患者预后的影响因素.结果 单因素分析显示,好转组与恶化/死亡组患者的意识障碍、血白细胞计数、脑肿胀间差异有统计学意义(P<0.05);多因素分析结果显示,入院时的意识障碍和脑脊液氯化物水平降低为影响预后的独立危险因素.结论 入院时即有意识障碍和脑脊液氯化物水平降低的结核性脑膜炎患者,临床预后较差.

  15. Advances on the factors affecting the prognosis of patients with tongue cancer%舌癌患者预后的影响因素研究现状

    Institute of Scientific and Technical Information of China (English)

    颜彦

    2012-01-01

    楔状缺损是非龋性疾病中的常见病,是牙齿唇、颊面牙颈部硬组织发生慢性消耗所致的缺损.其缺损由两个平面相交而成,边缘整齐,表面坚硬光滑,一般均为牙体硬组织本色,有时可有不同程度的着色好发生于前磨牙,尤其是第一前磨牙,随着年龄增长,楔状缺损有增加的趋势,年龄愈大,楔状缺损愈严重.近年来国内外学者对于楔状缺损的病因学研究更加深入、临床治疗进展的报道也越来越多,本文对楔状缺损的病因、流行情况及治疗进展进行综述.%Tongue in oral cancer with high incidence, prone to lymph node metastasis, prognosis is poor, therefore looking for effects of patients with tongue cancer prognostic factors and index is always the hot research of tongue cancer. The factors affecting the prognosis of tongue cancer more research are discussed, The aim of this article is to throw out a minnow to catch a whale and improve on tongue cancer awareness,and to promte the treatment result of tongue cancer.

  16. Correlation of human epidermal growth factor receptor 2 expression with clinicopathological characteristics and prognosis in gastric cancer

    OpenAIRE

    2013-01-01

    AIM: To investigate human epidermal growth factor receptor 2 (HER2) gene amplification and protein expression in Chinese patients with resectable gastric cancer and the association with clinicopathological characteristics and survival.

  17. Interaction Between Childhood Adversity, Brain-Derived Neurotrophic Factor val/met and Serotonin Transporter Promoter Polymorphism on Depression : The TRAILS Study

    NARCIS (Netherlands)

    Nederhof, E; Bouma, Esther; Oldehinkel, A.J.; Ormel, J.

    2010-01-01

    Background: The three-way interaction between the functional polymorphism in the serotonin transporter gene linked promoter region, the val66met polymorphism in the brain-derived neurotrophic factor gene, and childhood adversity in the prediction of depression in children, reported by Kaufman and co

  18. Intellectual disability: definition, etiological factors, classification, diagnosis, treatment and prognosis Discapacidad intelectual: definición, factores etiológicos, clasificación, diagnóstico, tratamiento y prognosis

    OpenAIRE

    Gregorio Katz; Eduardo Lazcano-Ponce

    2008-01-01

    Etiology and classification: Causal factors related with cognitive disability are multiples and can be classified as follows: Genetic, acquired (congenital and developmental), environmental and sociocultural. Likewise, in relation to the classification, cognitive disability has as a common denominator a subnormal intellectual functioning level; nevertheless, the extent to which an individual is unable to face the demands established by society for the individual’s age group has brought about ...

  19. Frequent Mental Distress, Chronic Conditions, and Adverse Health Behaviors in the Behavioral Risk Factor Surveillance Survey, Jordan, 2007

    Directory of Open Access Journals (Sweden)

    Mohannad Al-Nsour, MD, MSc

    2013-08-01

    Full Text Available Introduction Recent evidence indicates that chronic diseases and mental illness are associated. In the Middle Eastern country of Jordan, chronic diseases and frequent mental distress (FMD are increasing; however, the capacity for mental health care is limited. The objective of this study was to determine the association between FMD, chronic conditions, and adverse health behaviors in Jordan. Methods The third cycle of the Jordan Behavioral Risk Factor Surveillance Survey (2007 served as the data source for this study. The sample consisted of 3,612 noninstitutionalized Jordanian adults aged 18 years or older. Logistic regression was used to obtain odds ratios for the association between chronic conditions, health behaviors, and FMD adjusted for age, sex, marital status, education, income, and employment. Results In the adjusted models, people with hypertension (adjusted odds ratio [AOR], 2.0; 95% confidence interval [CI], 1.6–2.7, high cholesterol (AOR, 2.3; 95% CI, 1.6–3.2, diabetes (AOR, 1.6; 95% CI, 1.1–2.4, and asthma (AOR, 2.2; 95% CI, 1.5–3.1 and smokers (AOR, 1.5; 95% CI, 1.1–2.0 were more likely to have FMD than people without each of these conditions. Adults who reported vigorous physical activity were less likely to have FMD (AOR, 0.6; 95% CI, 0.4–0.9 than their less active counterparts. Conclusions In Jordan, FMD was associated with several chronic conditions. As a result, we suggest additional research to examine the complex relationship between FMD and chronic conditions. More doctors in the primary health care system should be trained in mental health.

  20. Analysis of adverse events and predisposing factors in voluntary and replacement whole blood donors: A study from north India

    Directory of Open Access Journals (Sweden)

    Naveen Agnihotri

    2012-01-01

    Full Text Available Background: Lack of awareness and community motivation, compounded with fragmented blood transfusion services in our country, Often leads to shortage of blood. Donor recruitment and retention are essential for ensuring adequate blood supply. However, adverse events (AEs in donors have a negative impact on donor return. Aims and Objectives: The present study was aimed to assess the frequency of AEs in whole blood donors and analyze the predisposing factors for AEs. Material and Methods: The study was conducted on allogeneic whole blood donors over a period of 14 months, i.e., from January 2002 to February 2003. A total of 37,896 donors were monitored for any AEs: 22587 (59.6% were voluntary donors (VD and 15,309 (40.4% were replacement donors (RD. Results: Overall reaction rate was 2.5% with vasovagal reactions constituting 63.5% and hematomas 35.0% of all reactions. Vasovagal reactions showed a significant association with young age, lower weight, first time donation status, female gender, and nature of blood donation camps. Amongst male donors, RDs had more reactions (P=0.03 than VDs. Majority of donors (85% with vasovagal reactions admitted to some fear or anxiety prior to donation. Hematoma formation occurred significantly more when less trained staff performed phlebotomy. Conclusion: Donor safety is an essential prerequisite to increase voluntary blood donation. AE analysis helps in identifying the blood donors at risk of donor reactions and adopting appropriate donor motivational strategies, pre-donation counseling, and care during and after donation.

  1. Research progress of environmental factors of adverse pregnancy outcomes%不良妊娠结局的环境因素研究进展

    Institute of Scientific and Technical Information of China (English)

    姜波玲; 卢媛

    2013-01-01

    妊娠不良结局的相关因素很多,这些危险因素影响着孕妇的健康,增加不良妊娠结局风险,包括早产、低出生体重、出生缺陷等。导致妊娠不良结局的原因目前主要分为母体、胎儿、环境三方面。研究环境因素与不良妊娠结局的关系,减少孕妇高危环境暴露,提前采取干预措施,可避免不良妊娠结局的发生。该文就不良妊娠结局的环境因素研究进展进行综述。%There are many related risk factors of adverse pregnancy outcomes , which affect the health of pregnant women and lead to the increase of adverse pregnancy outcomes , including preterm delivery, low birth weight, birth defects, etc.The causes of adverse pregnancy outcomes are mainly from the aspects of parent , fetus and environment .Studying on the relationship between environmental factors and adverse pregnancy outcomes of pregnant women , reducing environment exposure of pregnant women and taking preventive measures beforehand can avoid adverse pregnancy outcomes .This article gave an overview of research progress on environmental factors in adverse pregnancy outcome .

  2. Factors Affecting Postoperative Prognosis in the Solitary-nodule Type of Hepatocellular Carcinoma : Experience of 132 Cases in our Institute

    OpenAIRE

    Asahara, Toshimasa; Dohi, Kiyohiko; KATAYAMA, Koji; ITAMOTO, TOSHIYUKI; Okamoto, Yuzo; Nakahara, Hideki; Ono, Eiji; Sugino, Keizo; Marubayashi, Seiji; Yahata, Hiroshi; Kitamoto, Mikiya; Nakanishi, Toshio; Azuma, Kazuyoshi; Ito, Katsuhide; SHIMAMOTO, FUMIO

    1998-01-01

    A retrospective analysis of clinical and pathological factors was performed on 132 surgical cases with solitary-nodule type HCC in our hospital. The overall cancer-free survival rates after 1, 3 and 5 years were 82.2%, 42.3% and 26.5%, respectively. With univariate analysis, the significant prognostic factors for survival were tumor size, cancer cell infiltration of the fibrous capsule of the tumor (fc-inf), invasion into portal vein (vp), and intrahepatic metastasis (im), while significant p...

  3. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Overview Cancer Screening Overview–for health professionals Screening Tests Research Diagnosis and Staging Symptoms Diagnosis Staging Prognosis ... Cancer Prevention Overview Screening Cancer Screening Overview Screening Tests Diagnosis & Staging Symptoms Diagnosis Staging Prognosis Treatment Types ...

  4. Neutralization of IL-8 prevents the induction of dermatologic adverse events associated with the inhibition of epidermal growth factor receptor

    DEFF Research Database (Denmark)

    Bangsgaard, Nannie; Houtkamp, Mischa; Schuurhuis, Danita H;

    2012-01-01

    to treatment. Currently, the pathways involved in EGFR inhibitor-induced rash are poorly understood and few treatment options for this adverse event are available. Here, we developed a model for induction of papulopustular rash in healthy human volunteers by subcutaneous injection of the anti-EGFR monoclonal......, characterized by acute follicular neutrophil-rich hair follicle inflammation, and thus mimicked adverse events induced by systemic administration of EGFR inhibitors. In this model, we tested the hypothesis that neutrophils, attracted by IL-8, play a central role in the observed rash. Indeed, concomitant local...... repeat dose treatment with HuMab-10F8, a neutralizing human antibody against IL-8, reduced the rash. Inhibition of IL-8 can therefore ameliorate dermatological adverse events induced by treatment with EGFR inhibitors....

  5. Adverse life events as risk factors for behavioural and emotional problems in a 7-year follow-up of a population-based child cohort

    DEFF Research Database (Denmark)

    Rasmussen, Cathrine Skovmand; Nielsen, Louise Gramstrup; Petersen, Dorthe Janne;

    2014-01-01

    Background and aim: The aim of the study was to identify risk factors for significant changes in emotional and behavioural problem load in a community-based cohort of Danish children aged 9-16 years, the risk factors being seven parental and two child-related adverse life events. Methods: Data on...... emotional and behavioural problems was obtained from parents filling in the Child Behavior Checklist (CBCL) when the child was 8-9 and again when 15 years old. Data on risk factors was drawn from Danish registers. Analysis used was logistic regression for crude and adjusted change. Results: Parental divorce...... significantly raised the odds ratio of an increase in emotional and behavioural problems; furthermore, the risk of deterioration in problem behaviour rose significantly with increasing number of adverse life events. By dividing the children into four groups based on the pathway in problem load (increasers...

  6. Prognosis value of Hypoxia-inducible factor-1α expression in patients with bone and soft tissue sarcoma: a meta-analysis.

    Science.gov (United States)

    Li, Yongjiang; Zhang, Wenbiao; Li, Shuangjiang; Tu, Chongqi

    2016-01-01

    The prognostic significance of Hypoxia-inducible factor-1α (HIF-1α) in patients with bone and soft tissue sarcoma remains controversial. To investigate the impact of its expression on survival outcomes, we performed a meta-analysis. Comprehensive literature searches were conducted in PubMed, Web of Science, Embase and Cochrane Library. A total of 16 studies published from 2006 to 2015 were included. We found that expression of HIF-1α was significantly associated with higher rate of metastasis (RR 3.21, 95 % CI 2.12-4.84, P < 0.001), poorer overall survival (HR 2.05, 95 % CI 1.51-2.77, P < 0.001) and poorer disease-free survival (HR 2.05, 95 % CI 1.55-2.70, P < 0.001). In addition, when subgroup analysis was conducted according to histology type, the significant correlations to poor overall survival and disease-free survival were also observed in patients with osteosarcoma, chondrosarcoma and soft tissue sarcoma. Publication bias was not found and sensitivity analysis showed the results were stable. In conclusion, HIF-1α expression might be an effective predicative factor of poor prognosis for bone and soft tissue sarcoma. PMID:27606158

  7. Human leptospirosis: Management and prognosis

    OpenAIRE

    Kobayashi Y.

    2005-01-01

    As leptospirosis is a treatable disease, early diagnosis and prompt treatment are important for better prognosis. Early diagnosis depends on the knowledge of epidemiological factors, presenting features and use of appropriate laboratory tests. Early institution of appropriate antimicrobial therapy in combination with supportive therapy reduces the mortality from this disease. Leptospires are sensitive to a variety of antimicrobial agents, including penicillin, cephems, aminoglycosides, tetrac...

  8. Role of von Willebrand factor levels in the prognosis of stage Ⅳ colorectal cancer: Do we have enough evidence?

    Institute of Scientific and Technical Information of China (English)

    I. Gil-Bazo; J. A Díaz-González; J. Rodríguez; J. Cortés; E. Calvo; J. A. Páramo; J. García-Foncillas

    2005-01-01

    @@ TO THE EDITOR Cancer patients usually present a prothrombotic condition.Several clotting-related proteins, such as yon Willebrand factor (vWF), presenting higher plasma concentrations in these patients, may play a key role in this process. Moreover,some of those proteins are currently being characterized as response rate and overall survival markers in metastatic colorectal cancer (MCRC). In this comment article, we discuss the last piece of evidence that supports the use of vWF as a prognostic indicator in MCRC patients, provided by a paper recently published by Wang et al., in the World Journal of Gastroenterology. Summarizing, although vWF should be seriously considered as potential future prognostic and predictive indicator in colorectal cancer, more dynamic and better designed studies in longer series of patients should be conducted before standardizing its universal use among these patients.

  9. Incidence, risk factors, and prognosis of acute kidney injury following transarterial chemoembolization in patients with hepatocellular carcinoma: A prospective cohort study

    Directory of Open Access Journals (Sweden)

    J F Hao

    2014-01-01

    Full Text Available Background: Transcatheter arterial chemoembolization (TACE is an effective first-line therapy for intermediate stage hepatocellular carcinoma (HCC. Acute renal injury may be induced after transarterial chemoembolization because of iodinated radiocontrast medium, but its incidence, risk factors, and prognosis remain unclear. Patients and Methods: This prospective study enrolled 166 HCC patients with a total of 316 TACE treatments. The incidence, risk factors, and prognosis of acute kidney injury (AKI were examined. Results: The incidence of post-TACE AKI was 21.84% (69/316 according to Barrett and Parfrey criteria, whereas 7.59% (24/316 according to acute kidney injury network (AKIN criteria. Multivariate logistic regression analysis showed that serum total bilirubin (TB (>13.5 μmol/L; odds ratio [OR]: 1.871 95% confidence interval [CI]: 1.044-3.352; P = 0.035 and hemoglobin (HGB level (55 years; OR: 3.456, 95% CI: 1.107-10.790; P = 0.033, post-TACE AKI history (OR: 7.108, 95% CI: 1.387-36.434, P = 0.019, and serum aminotransferase level (>55 U/L; OR: 4.420, 95% CI: 1.792-10.906; P = 0.001 were associated with the development of AKI after TACE procedure in accordance to AKIN criteria. Total hospitalization cost was significantly higher (P = 0.034 in the patients with AKI after TACE procedure according to Barrett and Parfrey criteria. A post-TACE AKI diagnosis was associated with mortality in any definition used (P = 0.034 and P = 0.001 for Barrett and Parfrey and AKIN criteria, respectively. Conclusion: The present study showed that the incidence of post-TACE AKI was high in HCC patients (i.e., 7.59-21.84% depending on criteria used. HGB (13.5, and aminotransferase level (>55 U/L, age (>55 years and post-TACE AKI history may be predictors of post-TACE AKI in HCC patients. The development of post-TACE AKI was associated with the risk of renal replacement treatment, prolonged renal insufficiency, or mortality according to AKIN criteria.

  10. Effect of Factor XIII-A G185T Polymorphism on Visual Prognosis after Photodynamic Therapy for Neovascular Macular Degeneration

    Directory of Open Access Journals (Sweden)

    Francesco Parmeggiani

    2015-08-01

    Full Text Available Macular degenerations represent leading causes of central blindness or low vision in developed countries. Most of these severe visual disabilities are due to age-related macular degeneration (AMD and pathologic myopia (PM, both of which are frequently complicated by subfoveal choroidal neovascularization (CNV. Photodynamic therapy with verteporfin (PDT-V is still employed for CNV treatment in selected cases or in combined regimen. In Caucasian patients, the common polymorphism G185T of factor XIII-A gene (FXIII-A-G185T; rs5985 has been described as predictor of poor angiographic CNV responsiveness to PDT-V. Nevertheless, the prognostic implications of this pharmacogenetic determinant on long-term visual outcome after a PDT-V regimen have not been evaluated. We retrospectively selected Caucasian patients presenting with treatment-naive CNV and receiving standardized PDT-V protocol for two years. The study population included patients affected by subfoveal CNV secondary to AMD or PM. We assessed the correlations between the polymorphic allele T of FXIII-A-G185T and: (1 total number of photodynamic treatments; and (2 change in visual acuity from baseline to the end of the follow-up period. Considering a total study population of 412 patients with neovascular AMD or PM, the carriers of 185 T-allele of FXIII-A (GT or TT genotype received a higher number of photodynamic treatments than patients without it (GG wild-type genotype (p < 0.01; mean number of PDT-V: 5.51 vs. 3.76, respectively. Moreover, patients with 185 T-allele of FXIII-A had a more marked worsening of visual acuity at 24 months than those with the GG-185 wild genotype (p < 0.01; mean difference in logMAR visual acuity: 0.22 vs. 0.08, respectively. The present findings show that the G185T polymorphism of the FXIII-A gene is associated with significant differences in the long-term therapeutic outcomes of patients treated with standardized PDT-V protocol. The comprehensive appraisal of

  11. Hand eczema - prognosis and consequences

    DEFF Research Database (Denmark)

    Petersen, A. H.; Johansen, J D; Hald, M

    2014-01-01

    patients with hand eczema, the occupational consequences and to identify risk factors associated with a poor prognosis. MATERIALS AND METHODS: In all, 536 patients with hand eczema participated and were examined by a dermatologist. The clinical severity was assessed at baseline and 7 years later using a...... eczema in other body locations during the follow-up period were risk factors of a poor prognosis. The same factors, as well as being a woman, were associated with occupational consequences and low health-related quality of life. Of those with persistent hand eczema only 40% had visited a dermatologist......BACKGROUND: Hand eczema is recognized as a long-lasting disease with personal and societal repercussions. Long-term studies are required to generate information on factors contributing to a poor outcome. OBJECTIVES: The aims of this 7-year follow-up study were to evaluate the clinical course of...

  12. Are hand preference and sexual orientation possible predicting factors for finasteride adverse effects in male androgenic alopecia?

    Science.gov (United States)

    Motofei, Ion G; Rowland, David L; Georgescu, Simona R; Tampa, Mircea; Baleanu, Bogdan C; Paunica, Stana

    2016-07-01

    Sexual side effects of finasteride seem to be redoubtable, being encountered not only during therapy but also after treatment cessation. Consequently, any possible clinical/paraclinical elements that might predict these adverse effects would be useful in the selection of a therapeutic strategy for male androgenic alopecia. Previous published studies show that some compounds that interfere with sexual hormones can decrease sexual activation and response, according to hand preference (as reported for finasteride and tamoxifen) and according to sexual orientation (as noted for bicalutamide). Our preliminary published data and the arguments presented here suggest that these two individual parameters might be used by dermatologists in the therapeutic approach of male androgenic alopecia, so as to alert specific subsets of men, prior to treatment, of the potential increased risk for developing adverse effects to finasteride. PMID:26990657

  13. Extent of poly-pharmacy, occurrence and associated factors of drug-drug interaction and potential adverse drug reactions in Gondar Teaching Referral Hospital, North West Ethiopia

    OpenAIRE

    Endalkachew Admassie; Tesfahun Melese; Woldeselassie Mequanent; Wubshet Hailu; B Akshaya Srikanth

    2013-01-01

    The aim of this study was to assess the extent of poly-pharmacy, occurrence, and associated factors for the occurrence of drug–drug interaction (DDI) and potential adverse drug reaction (ADR) in Gondar University Teaching Referral Hospital. Institutional-based retrospective cross-sectional study. This study was conducted on prescriptions of both in and out-patients for a period of 3 months at Gondar University Hospital. Both bivariate analysis and multivariate logistic regression were used to...

  14. Codeine Ultra-rapid Metabolizers: Age Appears to be a Key Factor in Adverse Effects of Codeine.

    Science.gov (United States)

    Heintze, K; Fuchs, W

    2015-12-01

    Codeine is widely used as an analgesic drug. Taking into account the high consumption of codeine, only few fatal adverse events have been published. A number of reports, where neonates and children showed serious or fatal adverse reactions, led to a restriction of the use of codeine in this patient group. Therefore, we reviewed the safety of codeine in adults. PubMed was systematically searched for clinical studies and case reports, with a special focus on CYP2D6, the enzyme that converts codeine to morphine and exhibits genetic polymorphism.181 cases were identified in adults in conjunction with serious or lethal effects of codeine. In the vast majority of cases, codeine was used in combination with other drugs by drug-dependent individuals or with a suicidal intent. Only 2 cases were found where ultra-rapid metabolizers experienced severe non-lethal adverse events. This is far less than would be predicted from the number of cases reported in children. The discrepancy may be explained by developmental changes in the disposition of codeine.The strategy of regulatory authorities to restrict access to codeine for infants and young children, the apparent highest risk group, has a factual and pharmacological rationale. By the same standards, there is no need for restrictions for adult use of codeine. PMID:25585351

  15. Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models.

    Science.gov (United States)

    Sánchez, M M; Ladd, C O; Plotsky, P M

    2001-01-01

    Increasing evidence supports the view that the interaction of perinatal exposure to adversity with individual genetic liabilities may increase an individual's vulnerability to the expression of psycho- and physiopathology throughout life. The early environment appears to program some aspects of neurobiological development and, in turn, behavioral, emotional, cognitive, and physiological development. Several rodent and primate models of early adverse experience have been analyzed in this review, including those that "model" maternal separation or loss, abuse or neglect, and social deprivation. Accumulating evidence shows that these early traumatic experiences are associated with long-term alterations in coping style, emotional and behavioral regulation. neuroendocrine responsiveness to stress, social "fitness,' cognitive function, brain morphology, neurochemistry, and expression levels of central nervous system genes that have been related to anxiety and mood disorders. Studies are underway to identify important aspects of adverse early experience, such as (a) the existence of "sensitive periods" during development associated with alterations in particular output systems. (b) the presence of "windows of opportunity" during which targeted interventions (e.g., nurturant parenting or supportive-enriching environment) may prevent or reverse dysfunction, (c) the identity of gene polymorphisms contributing to the individual's variability in vulnerability, and (d) a means to translate the timing of these developmental "sensitive periods" across species. PMID:11523842

  16. The road to success. Long-term prognosis for persons living with HIV in Denmark - time trends and risk factors.

    Science.gov (United States)

    Lohse, Nicolai

    2016-02-01

    The work on this thesis began in 2003 when the global HIV epidemic was out of control. A minority of persons with HIV were benefitting fully from the recently introduced highly efficacious antiretroviral therapy (ART) combinations. Among the global challenges were lack of access to good healthcare, drug toxicity, and emergence of drug-resistant virus. It was unknown how long the drugs could maintain their efficacy in the individual even if administered as intended, and there was a fear that the increased drug pressure would increase the prevalence of drug resistance, subsequently leading to transmission of resistant virus from one individual to another, and thereby waning the treatment options available. Hence, we were far from the ideal conditions where an HIV-infected individual gets to know immediately that he/she is infected, has access to specialized medical and social support, receives a drug combination which effectively suppresses the virus and has no side effects, and is free of co-morbid conditions both before and after he/she gets infected. The nine papers on which this thesis is based each aimed to provide new knowledge to aspects of the above. Late diagnosis and late presentation to clinical care continue to be major barriers to improved HIV management. We used nation-wide hospital registries to explore the potential for an indicator disease-based HIV testing strategy. A range of conditions that were manifestations of the HIV infection itself were found to be associated with highly increased risk of HIV diagnosis during the coming year, but less so three to five years later. Other conditions were associated with an almost constant five-year long increased risk of being diagnosed with HIV because they share behavioural risk factors with HIV, making them indicators of not only current HIV but also of future HIV acquisition. Hence, indicator condition-based testing should be adapted to the local epidemic and could be a valuable addition to the existing

  17. MAGE-A3 expression is an adverse prognostic factor in diffuse large B-cell lymphoma.

    Science.gov (United States)

    Olarte, Irma; Martinez, Adolfo; Ramos-Peñafiel, Christian; Castellanos-Sinco, Humberto; Zamora, Jorge; Collazo-Jaloma, Juan; Gutiérrez, Mario; Gutiérrez-Kobeh, Laila; Chavez-Olmos, Pedro; Manzanilla, Hugo; Garrido-Guerrero, Efraín; Ordoñez-Razo, Rosa M; Miranda, Enrique I

    2011-11-01

    This study evaluates the prognostic value of MAGE-A3 expression in 28 diffuse large B-cell lymphoma (DLBCL) patients. A significant association was observed between MAGE-A3 expressions, assessed by quantitative real-time RT-polymerase chain reaction (PCR), with advanced stages of disease (P < 0.05). Elevated serum lactate dehydrogenase (LDH) levels and International Prognostic Index (IPI) score were significantly higher in MAGE-A3-positive patients (P = 0.025 and P = 0.004, respectively). Expression of MAGE-A3 was associated with poor response to treatment and a significantly shorter overall survival (P < 0.001). Our data address new information in the association of MAGE-A3 expression and poor prognosis in DLBCL patients. PMID:22183072

  18. Analysis of the tumor length and other prognosis factors in pT1-2 node-negative esophageal squamous cell carcinoma in a Chinese population

    Directory of Open Access Journals (Sweden)

    Song Zhengbo

    2012-12-01

    Full Text Available Abstract Background Tumor length is an important prognostic factor for many carcinomas, but its role in esophageal cancer remained undetermined. The aim of this study was to investigate the effect of tumor length on survival for patients with confined tumors (grade pT1-2 without lymph-node metastases in esophageal squamous cell carcinoma. Methods We enrolled 201 patients with esophageal squamous cell carcinoma (SCC who had undergone surgical resection and been confirmed as pT1-2N0M0. The relationship of tumor length with overall survival was assessed and compared with other factors detailed in the American Joint Committee on Cancer (AJCC tumor, node, metastasis (TNM staging system published in 2009. Results The overall survival (OS rates at 1, 3, and 5 years were 93.0%, 83.7%, and 69.2%, respectively. The tumor length adversely affected OS, with the 5-year rate being 93.5%, 82.0%, 68.6%, 67.9%, 55.3% and 41.1%, respectively for tumor lengths of less than 10 mm, 10 to 20 mm, 20 to 30 mm, 30 to 40 mm, 40 to 50 mm, and greater than 50 mm (PP = 0.04, as did the other current TNM factors. Conclusion Tumor length appears to affect the OS of patients with early-stage esophageal squamous cell carcinoma. It may provide additional prognostic information for the current TNM staging system.

  19. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... our information on Coping With Cancer helpful. Understanding Statistics About Survival Doctors estimate prognosis by using statistics that researchers have collected over many years about ...

  20. Neurofilament Heavy polypeptide CpG island methylation associates with prognosis of renal cell carcinoma and prediction of antivascular endothelial growth factor therapy response

    International Nuclear Information System (INIS)

    Neurofilament Heavy polypeptid (NEFH) belongs to the group of type IV intermediate filament proteins. DNA methylation of the NEFH promoter and loss of expression have previously been shown to activate the AKT/β-catenin pathway in tumor cells. When identifying hypermethylation of the NEFH CpG island (CGI) in renal cell cancer (RCC) we asked whether methylation could provide clinical or prognostic information for RCC and/or predict therapy response in patients with metastatic RCC (mRCC) undergoing antiangiogenic therapy. Relative methylation of the NEFH CGI was analyzed in 132 RCC samples and 83 paired normal tissues using quantitative methylation-specific PCR. Results were statistically compared with tumor histology, clinicopathological parameters, progression-free survival (PFS) as well as with overall survival (OS) in a subset of 18 mRCC patients following antiangiogenic therapy regimens. The NEFH CGI methylation demonstrated a tumor-specific increase (P < 0.001), association with advanced disease (P < 0.001), and distant metastasis (P = 0.005). Higher relative methylation was also significantly associated with a poor PFS (HR = 8.6, P < 0.001) independent from the covariates age, gender, diameter of tumors, state of advanced disease, and local and distant metastasis. Median OS following targeted therapy was 29.8 months for patients with low methylation versus 9.8 months for the group with high methylation (P = 0.028). We identified NEFH methylation as a candidate epigenetic marker for prognosis of RCC patients as well as prediction of anti-vascular endothelial growth factor-based therapy response

  1. Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma

    Directory of Open Access Journals (Sweden)

    Li Xin

    2010-04-01

    Full Text Available Abstract Background The aim of the present study was to analyze the expression of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1 in nasopharyngeal carcinoma (NPC and its correlation with clinicopathologic features, including patients' survival time. Methods Using real-time PCR, we detected the expression of EIF4G1 in normal nasopharyngeal tissues, immortalized nasopharyngeal epithelial cell lines NP69, NPC tissues and cell lines. EIF4G1 protein expression in NPC tissues was examined using immunohistochemistry. Survival analysis was performed using Kaplan-Meier method. The effect of EIF4G1 on cell invasion and tumorigenesis were investigated. Results The expression levels of EIF4G1 mRNA were significantly greater in NPC tissues and cell lines than those in the normal nasopharyngeal tissues and NP69 cells (P EIF4G1 protein was higher in NPC tissues than that in the nasopharyngeal tissues (P EIF4G1 protein in tumors were positively correlated with tumor T classification (P = 0.039, lymph node involvement (N classification, P = 0.008, and the clinical stages (P = 0.003 of NPC patients. Patients with higher EIF4G1 expression had shorter overall survival time (P = 0.019. Multivariate analysis showed that EIF4G1 expression was an independent prognostic indicator for the overall survival of NPC patients. Using shRNA to knock down the expression of EIF4G1 not only markedly inhibited cell cycle progression, proliferation, migration, invasion, and colony formation, but also dramatically suppressed in vivo xenograft tumor growth. Conclusion Our data suggest that EIF4G1 can serve as a biomarker for the prognosis of NPC patients.

  2. Factors affecting the development of adverse drug reactions to β-blockers in hospitalized cardiac patient population

    Directory of Open Access Journals (Sweden)

    Mugoša S

    2016-08-01

    Full Text Available Snežana Mugoša,1,2 Nataša Djordjević,3 Nina Djukanović,4 Dragana Protić,5 Zoran Bukumirić,6 Ivan Radosavljević,7 Aneta Bošković,8 Zoran Todorović5,9 1Department of Pharmacotherapy, Faculty of Pharmacy, University of Montenegro, 2Clinical Trial Department, Agency for Medicines and Medical Devices of Montenegro, Podgorica, Montenegro; 3Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 4High Medical School “Milutin Milanković”, Belgrade, 5Department of Pharmacology, Clinical Pharmacology and Toxicology, 6Institute for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, 7Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 8Clinic for Heart Diseases, Clinical Centre of Montenegro, Podgorica, Montenegro; 9Department of Clinical Immunology and Allergy, Medical Center “Bežanijska kosa”, Belgrade, Serbia Abstract: The aim of the present study was to undertake a study on the prevalence of cytochrome P450 2D6 (CYP2D6 poor metabolizer alleles (*3, *4, *5, and *6 on a Montenegrin population and its impact on developing adverse drug reactions (ADRs of β-blockers in a hospitalized cardiac patient population. A prospective study was conducted in the Cardiology Center of the Clinical Center of Montenegro and included 138 patients who had received any β-blocker in their therapy. ADRs were collected using a specially designed questionnaire, based on the symptom list and any signs that could point to eventual ADRs. Data from patients’ medical charts, laboratory tests, and other available parameters were observed and combined with the data from the questionnaire. ADRs to β-blockers were observed in 15 (10.9% patients. There was a statistically significant difference in the frequency of ADRs in relation to genetically determined enzymatic activity (P<0.001, with ADRs’ occurrence significantly

  3. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Questions to Ask about Your Diagnosis Research Understanding Cancer Prognosis Oncologist Anthony L. Back, M.D., a ... for provider care teams (PDF-210KB). Understanding Your Cancer Prognosis Video View this video on YouTube. Three ...

  4. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... suggest that your cancer is likely to respond well to treatment. Or, he may tell you that you have a poor prognosis if the cancer is harder to control. Whatever your doctor tells you, keep in mind that a prognosis is an educated guess. Your doctor cannot be certain how it will go for you. If ...

  5. Periodontal disease as a risk factor for adverse pregnancy outcomes: a systematic review and meta-analysis of case-control studies.

    Science.gov (United States)

    Corbella, Stefano; Taschieri, Silvio; Francetti, Luca; De Siena, Francesca; Del Fabbro, Massimo

    2012-07-01

    Periodontal disease is a highly prevalent group of illnesses of microbial etiology, whose consequence is a severe breakdown of tooth-supporting structures. A link between periodontal infection and several systemic conditions, among which adverse pregnancy outcomes, has been suggested in the recent years. The aim of this review based on case-control studies was to evaluate if periodontal disease could be considered as a risk factor for preterm birth, low birth-weight and preterm low birth-weight. An electronic search (via Pubmed) was performed for case-control studies investigating the relationship between periodontal disease and adverse pregnancy outcomes. From the initially retrieved 417 articles, 17 case-control studies, accounting for a total of 10,148 patients, were included in the review and in the meta-analysis. The estimated odds ratio was 1.78 (CI 95%: 1.58, 2.01) for preterm birth, 1.82 (CI 95%: 1.51, 1.20) for low birth-weight and 3.00 (CI 95%: 1.93, 4.68) for preterm low birth-weight. Despite the results of the analysis of pooled data suggested a link between periodontal diseases and adverse pregnancy outcomes, the presence of important confounders, whose effect could not be addressed, prevents a validation of the meta-analysis outcomes. Further more accurate investigations based on individual data analysis could give a better insight into the topic of the present review. PMID:21739194

  6. Stromal Cell-Derived Factor 1 Gene Polymorphism Is Associated with Susceptibility to Adverse Long-Term Allograft Outcomes in Non-Diabetic Kidney Transplant Recipients

    Directory of Open Access Journals (Sweden)

    Chung-Jieh Wang

    2014-07-01

    Full Text Available Although the genetic polymorphism of Stromal Cell-Derived Factor 1 (SDF-1 is associated with higher mortality of liver allograft recipients, the role of SDF-1 in the modulation of renal allograft outcomes is unclear. Between March 2000 and January 2008, we recruited 252 non-diabetic renal transplant recipients (RTRs. Baseline characteristics and blood chemistry were recorded. Genomic DNA extraction with polymerase chain reaction-restriction fragment length polymorphism was utilized to analyze the genetic polymorphisms of SDF-1 (rs1801157. The influence of SDF-1 on an adverse renal allograft outcome, defined as either a doubling of serum creatinine, graft failure, or patient death was evaluated. Sixteen patients with the SDF-1 AA/AG genotype and nine with the SDF-1 GG genotype reached an adverse outcome. According to Kaplan-Meier analysis, patients carrying the SDF-1 AA/AG genotype or A allele showed a significantly higher risk of reaching an adverse outcome than those carrying the SDF-1 GG genotype or G allele (p = 0.041; p = 0.0051, respectively; log rank test. Stepwise multivariate Cox proportional regression analysis revealed that patients carrying the SDF-1 AA/AG genotype and A allele had a 2.742-fold (95% CI. 1.106–6.799, p = 0.03 and 2.306-fold (95% CI. 1.254–4.24, p = 0.008 risk of experiencing an adverse outcome. The SDF-1 AA/AG genotype and A allele have a detrimental impact on the long-term outcome of RTRs.

  7. Negative Effects of Psychological Treatments: An Exploratory Factor Analysis of the Negative Effects Questionnaire for Monitoring and Reporting Adverse and Unwanted Events.

    Science.gov (United States)

    Rozental, Alexander; Kottorp, Anders; Boettcher, Johanna; Andersson, Gerhard; Carlbring, Per

    2016-01-01

    Research conducted during the last decades has provided increasing evidence for the use of psychological treatments for a number of psychiatric disorders and somatic complaints. However, by focusing only on the positive outcomes, less attention has been given to the potential of negative effects. Despite indications of deterioration and other adverse and unwanted events during treatment, little is known about their occurrence and characteristics. Hence, in order to facilitate research of negative effects, a new instrument for monitoring and reporting their incidence and impact was developed using a consensus among researchers, self-reports by patients, and a literature review: the Negative Effects Questionnaire. Participants were recruited via a smartphone-delivered self-help treatment for social anxiety disorder and through the media (N = 653). An exploratory factor analysis was performed, resulting in a six-factor solution with 32 items, accounting for 57.64% of the variance. The derived factors were: symptoms, quality, dependency, stigma, hopelessness, and failure. Items related to unpleasant memories, stress, and anxiety were experienced by more than one-third of the participants. Further, increased or novel symptoms, as well as lack of quality in the treatment and therapeutic relationship rendered the highest self-reported negative impact. In addition, the findings were discussed in relation to prior research and other similar instruments of adverse and unwanted events, giving credence to the items that are included. The instrument is presently available in eleven different languages and can be freely downloaded and used from www.neqscale.com. PMID:27331907

  8. Negative Effects of Psychological Treatments: An Exploratory Factor Analysis of the Negative Effects Questionnaire for Monitoring and Reporting Adverse and Unwanted Events

    Science.gov (United States)

    Kottorp, Anders; Boettcher, Johanna; Andersson, Gerhard; Carlbring, Per

    2016-01-01

    Research conducted during the last decades has provided increasing evidence for the use of psychological treatments for a number of psychiatric disorders and somatic complaints. However, by focusing only on the positive outcomes, less attention has been given to the potential of negative effects. Despite indications of deterioration and other adverse and unwanted events during treatment, little is known about their occurrence and characteristics. Hence, in order to facilitate research of negative effects, a new instrument for monitoring and reporting their incidence and impact was developed using a consensus among researchers, self-reports by patients, and a literature review: the Negative Effects Questionnaire. Participants were recruited via a smartphone-delivered self-help treatment for social anxiety disorder and through the media (N = 653). An exploratory factor analysis was performed, resulting in a six-factor solution with 32 items, accounting for 57.64% of the variance. The derived factors were: symptoms, quality, dependency, stigma, hopelessness, and failure. Items related to unpleasant memories, stress, and anxiety were experienced by more than one-third of the participants. Further, increased or novel symptoms, as well as lack of quality in the treatment and therapeutic relationship rendered the highest self-reported negative impact. In addition, the findings were discussed in relation to prior research and other similar instruments of adverse and unwanted events, giving credence to the items that are included. The instrument is presently available in eleven different languages and can be freely downloaded and used from www.neqscale.com. PMID:27331907

  9. Acute adverse reactions to radiographic iodinated and gadolinium-based contrast media: incidence, risk factors and premedication: from published evidence to a practical approach.

    Science.gov (United States)

    Tonolini, M; Bianco, R

    2011-01-01

    Although relatively uncommon especially in their severe manifestations, adverse reactions (ARs) to radiographic contrast media (CM) may represent a source of concern to both physicians and patients because of the large number of CT and MR imaging procedures daily performed. In this paper the current literature is reviewed regarding incidence and risk factors for acute ARs to both iodinated and gadolinium-based CM, and about the usefulness of pharmacological premedication to reduce risk. A practical approach for everyday clinical practice is proposed. PMID:22262334

  10. Relation of Serum Adiponectin Levels to Number of Traditional Atherosclerotic Risk Factors and All-Cause Mortality and Major Adverse Cardiovascular Events (from the Copenhagen City Heart Study)

    DEFF Research Database (Denmark)

    Lindberg, Soren; Mogelvang, Rasmus; Pedersen, Sune H;

    2013-01-01

    Adiponectin exerts anti-inflammatory and antiatherogenic effects and appears to protect against arteriosclerosis. Accordingly, an association between low concentrations of plasma adiponectin and cardiovascular (CV) disease has been demonstrated in several studies. In contrast, elevated plasma adi...... nonfatal myocardial infarction or ischemic stroke (n = 502). High adiponectin was inversely associated with an increasing number of traditional CV risk factors (p...... adiponectin has been associated with increased mortality and an increasing number of major adverse CV events (MACE). Because of these conflicting results, the true role of adiponectin remains to be elucidated. In the Copenhagen City Heart Study, we prospectively followed up 5,624 randomly selected men and...

  11. Prognostic risk factors and prognosis model for liver failure%肝衰竭预后危险因素及预后模型建立的研究

    Institute of Scientific and Technical Information of China (English)

    汤伟亮; 谢青; 赵钢德; 董志霞; 项晓刚; 王晖; 周惠娟; 桂红莲; 郭斯敏; 庄焱

    2011-01-01

    Objective To investigate the independent risk factors of the prognosis for liver failure and to establish a prognosis model. Methods The clinical data of 252 patients with liver failure treated in Ruijin hospital from Jun. 2006 to Dec. 2008 were retrospectively analyzed. Logistic regression analysis was used for selecting the independent risk factors for the prognosis of liver failure. Based on logistic regression analysis, the prognosis model for liver failure was established. Results Logistic regression analysis showed that age, hepatic eneephalopathy, upper gastrointestinal bleeding, infection, TBIL and PT were the independent risk factors for the prognosis of liver failure. Then the prognosis model was established. By calculating prognostic index and drawing receiver operating characteristic (ROC) curve, the area under the ROC curve was known to be 0.924 (95%CI 0.892, 0.957). Conclusions Age,hepatic encephalopathy, upper gastrointestinal bleeding, infection, TBIL and PT are the independent risk factors for the prognosis of liver failure. The prognosis model established in this study can predict short-term survival rate of patients with liver failure. It is of significant value in assessing the prognosis of liver failure.%目的 探讨影响肝衰竭预后的危险因素,并建立其预后模型.方法 回顾性调查2006年6月-2008年12月我科收治的252例肝衰竭患者的临床资料.采用多因素Logistic回归分析,得出相应的独立危险因素,并建立预后模型.结果 多因素Logistic回归分析显示,患者年龄、肝性脑病、上消化道出血、感染、TBIL、PT是影响肝衰竭患者预后的独立危险因素.对所得出的独立危险因素建立肝衰竭患者的预后判断模型,计算预后指数并绘制受试者工作特征曲线,其曲线下面积为0.924(95%CI0.892,0.957).结论 年龄、肝性脑病、上消化道出血、感染、TBIL、PT是影响肝衰竭患者预后的独立危险因素.本研究初步建立预

  12. Factors affecting the development of adverse drug reactions to β-blockers in hospitalized cardiac patient population

    Science.gov (United States)

    Mugoša, Snežana; Djordjević, Nataša; Djukanović, Nina; Protić, Dragana; Bukumirić, Zoran; Radosavljević, Ivan; Bošković, Aneta; Todorović, Zoran

    2016-01-01

    The aim of the present study was to undertake a study on the prevalence of cytochrome P450 2D6 (CYP2D6) poor metabolizer alleles (*3, *4, *5, and *6) on a Montenegrin population and its impact on developing adverse drug reactions (ADRs) of β-blockers in a hospitalized cardiac patient population. A prospective study was conducted in the Cardiology Center of the Clinical Center of Montenegro and included 138 patients who had received any β-blocker in their therapy. ADRs were collected using a specially designed questionnaire, based on the symptom list and any signs that could point to eventual ADRs. Data from patients’ medical charts, laboratory tests, and other available parameters were observed and combined with the data from the questionnaire. ADRs to β-blockers were observed in 15 (10.9%) patients. There was a statistically significant difference in the frequency of ADRs in relation to genetically determined enzymatic activity (Phospitalization, CYP2D6 poor metabolizer phenotype, and the concomitant use of other CYP2D6-metabolizing drugs. Therefore, in hospitalized patients with polypharmacy CYP2D6 genotyping might be useful in detecting those at risk of ADRs.

  13. Study on prognosis status and its influential factors in children with febrile convulsion%高热惊厥小儿预后现状和影响因素分析

    Institute of Scientific and Technical Information of China (English)

    蒋建军; 杨毅

    2012-01-01

    目的 探讨高热惊厥小儿预后现状和影响因素.方法 采用自编问卷收集2010年8月~2011年8月在湖南省永州市祁阳县人民医院儿科住院治疗的43例高热惊厥患儿临床资料.结果 在本研究入选的43例患儿中,35例患儿预后良好,预后良好率为81.40%,而预后不良率为18.60%,多因素Logistic回归分析发现初次发作年龄<1岁,高热惊厥持续时间≥15 min、高热惊厥次数≥2次和脑电图异常是高热惊厥患儿预后差危险因素.结论 高热惊厥患儿总体预后欠佳,预后影响因素较多,在对高热惊厥进行治疗的过程中,积极治疗高热惊厥,发作时尽可能在最短时间内止痉,改善患儿的预后.%Objective To investigate the prognosis status and its influential factors in children with febrile convulsion. Methods Clinical data of 43 children with febrile convulsion who were treated in the Department of Pediatric in the People's Hospital of Qiyang County in Yongzhou City, Hu'nan Province, from August 2010 to August 2011 were collected by self-made questionnaire. Results 43 children with febrile convulsion were favorable prognosis, the good prognosis rate was 81.40%, the bad prognosis rate was 18.60%, binary classification logistic regression analysis showed that first onset age <1 year old, febrile convulsion duration ≥15 min, febrile convulsion number ≥2 and electroencephalography abnormality were risk factors. Conclusion The prognosis status of children with febrile convulsion was bad. It is affected by various factors. We should give positive treatment and control attack as soon as possible to improve the prognosis of children with febrile convulsion.

  14. The colorectal carcinoma prognosis factors: Significance of diagnosis delay Factores pronósticos en carcinoma colorrectal: Importancia de la demora diagnóstica

    Directory of Open Access Journals (Sweden)

    E. Gómez-Domínguez

    2006-05-01

    Full Text Available Introduction: detection of early-stage colorectal carcinoma (CRC -( Dukes' A or B- provides better survival rates in these patients. Thus, the effectiveness of screening programs in asymptomatic patients or of early diagnosis in symptomatic individuals has been postulated. The aim of this study was to establish whether a delay in diagnosis or other factors are related to CRC stage. Patients and methods: a retrospective study was performed on 96 patients with CRC. Age at diagnosis, gender distribution, intestinal disorders, diagnosis delay, primary sign and -regarding CRC- localization, stage (Dukes' and grade of differentiation (well differentiated; non-well differentiated; poorly differentiated were recorded. Results: diagnosis delay was 185 ± 190 days. Patients delay in obtaining a diagnosis was 119 ± 158 days. In 40% of patients CRC was diagnosed at an early stage (Dukes' A or B, and in 13% CRC was poorly differentiated. The only factor with an independent effect on Dukes' stage was tumor differentiation (p: 0.0012. Distal location was associated with less advanced tumors without statistical significance (p: 0.156. Conclusion: based on the presented data, a greater effort regarding screening programs for healthy people seems warranted, as improved survival has been demonstrated when diagnosis delay is reduced, particularly in patients with the highest mean delay.Introducción: el diagnóstico precoz del cáncer colorrectal (estadios A y B de Dukes consigue mejorar las tasas de supervivencia de estos pacientes. Con este objetivo se ha propuesto como estrategia acelerar el diagnóstico de enfermos sintomáticos o realizar cribados en enfermos asintomáticos. El objetivo de este trabajo es identificar los factores que influyen en la extensión tumoral del carcinoma colorrectal, especialmente la demora en el diagnóstico. Material y métodos: estudio prospectivo de una serie de 99 pacientes diagnosticados de carcinoma colorrectal en los que se

  15. 老年急性脑卒中6个月预后及其影响因素%Six-month prognosis and the related influential factors in the elderly patients after acute cerebral stroke

    Institute of Scientific and Technical Information of China (English)

    陈金梅; 周维智; 刘晓红; 夏菁; 陈缪存; 戚幼文; 宋艳艳; 田发发

    2011-01-01

    目的:观察老年脑卒中患者急性期血压及相关因素,探讨其与6个月预后的关系.方法:老年脑卒中患者275例,连续记录入院后7 d的血压,在发病后6个月时评价预后(远期预后),对急性期血压及相关因素进行单因素和多因素Logistic回归分析.结果:Logistic回归分析显示年龄>76岁,入院NIHSS评分>7分,急性期平均收缩压≥200mm Hg,急性期平均舒张压≥100 mm Hg是老年脑卒中患者6个月预后的危险因素;坚持康复锻炼是老年脑卒中患者6个月预后的保护因素.结论:老年脑卒中急性期收缩压≥200 mm Hg、舒张压≥100 mm Hg、高龄以及NIHSS评分愈高提示预后不良,积极康复锻炼可改善远期(6个月)预后.%Objective To observe the blood pressure and the related influential factors in acute phase of the elderly patients with stroke in order to study the relationship with six-month prognosis.Methods The average blood pressure in the first seven days after admission was recorded. The longterm prognosis was assessed 6 months after stroke. The blood pressure and its related influential factors were analyzed with single factor analysis and multiple factors analysis methods. Results The logistic regression analysis showed the risk factors were as follows, the age over 76 years, the score of NIHSS over 7 at admission, the mean systolic blood pressure over 200 mm Hg and the mean diastolic blood pressure over 100 mm Hg in acute phase. Rehabilitation exercise was the protective factor for the six-month prognosis of the elderly stroke patients. Conclusion The elderly patient with the score of NIHSS over 7, the mean systolic blood pressure over 200 mm Hg, the mean diastolic blood pressure over 100 mm Hg and the age over 76 years will have a worse six-month prognosis. Active rehabilitation exercise can improve the six-month prognosis.

  16. Intervillous Macrophage Migration Inhibitory Factor Is Associated with Adverse Birth Outcomes in a Study Population in Central India

    OpenAIRE

    Singh, Puspendra P.; Lucchi, Naomi W.; Anna Blackstock; Venkatachalam Udhayakumar; Neeru Singh

    2012-01-01

    Macrophage migration inhibitory factor (MIF) is a pluripotent factor produced by a variety of cells. It plays an important biological role in the regulation of pregnancy and has been shown to influence malaria pathogenesis. In this study, the levels of MIF in the peripheral, cord and placental intervillous blood (IVB) plasma collected from women residing in a malaria endemic region of Central India was determined and its association with malaria in pregnancy and birth outcomes was investigate...

  17. Understanding Cancer Prognosis

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    Full Text Available ... How to best take care of yourself and manage treatment side effects How to deal with financial ... for patients (PDF-210KB) and for provider care teams (PDF-210KB). Understanding Your Cancer Prognosis Video View ...

  18. Understanding Cancer Prognosis

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    Full Text Available ... treatment Seeking Information About Your Prognosis Is a Personal Decision When you have cancer, you and your ... about it, and gain valuable insight from the personal ways each patient has approached questions about their ...

  19. Understanding Cancer Prognosis

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    Full Text Available ... were before cancer How you respond to treatment Seeking Information About Your Prognosis Is a Personal Decision ... artist, and her husband Roy discover how to support each other’s need for different kinds of information ...

  20. Understanding Cancer Prognosis

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    Full Text Available ... Back, M.D., coaches other oncologists about how to discuss prognosis with their patients. Good ... as the source. Please note that blog posts that are written by individuals from outside the ...

  1. Understanding Cancer Prognosis

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    Full Text Available ... Series This video series offers the perspectives of three cancer patients and their doctor. The videos explain ... Cancer Prognosis Video View this video on YouTube. Three cancer patients and their doctor, Anthony L. Back, ...

  2. Understanding Cancer Prognosis

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    Full Text Available ... your cancer and knowing what to expect can help you and your loved ones make decisions. Some ... what the statistics may mean. If you need help coping with your prognosis, you may find our ...

  3. Understanding Cancer Prognosis

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    Full Text Available ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ... Staging Prognosis Questions to Ask ... This statistic is another method used to estimate cancer-specific survival that does ...

  4. Understanding Cancer Prognosis

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    Full Text Available ... Research Diagnosis and Staging Symptoms Diagnosis Staging Prognosis Questions to Ask about Your Diagnosis Research Cancer Treatment Types of Treatment Side Effects Clinical Trials Information for Patients and Caregivers A ...

  5. Understanding Cancer Prognosis

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    Full Text Available ... survival. The estimate of how the disease will go for you is called prognosis. It can be ... Your doctor cannot be certain how it will go for you. If You Decide Not to Have ...

  6. Understanding Cancer Prognosis

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    Full Text Available ... Cancer Screening Overview–for health professionals Screening Tests Research Diagnosis and Staging Symptoms Diagnosis Staging Prognosis Questions to Ask about Your Diagnosis Research Cancer Treatment ...

  7. Understanding Cancer Prognosis

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    Full Text Available ... control. Whatever your doctor tells you, keep in mind that a prognosis is an educated guess. Your ... Still, some cancer cells can remain in your body for many years after treatment. These cells may ...

  8. Understanding Cancer Prognosis

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    Full Text Available ... treatment Seeking Information About Your Prognosis Is a Personal Decision When you have cancer, you and your ... think they are too impersonal to be of value to you. It is up to you to ...

  9. Understanding Cancer Prognosis

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    Full Text Available ... Cancer Common Cancer Types Bladder Cancer Breast Cancer Colorectal Cancer Kidney (Renal Cell) Cancer Leukemia Lung Cancer Lymphoma ... need for different kinds of information about her colorectal cancer prognosis. Diving Out of the Dark View this ...

  10. Understanding Cancer Prognosis

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    Full Text Available ... Research Cancer Treatment Types of Treatment Side Effects Clinical Trials Information for Patients and Caregivers A to ... Staging Prognosis Treatment Types of Treatment Side Effects Clinical Trials Cancer Drugs Complementary & Alternative Medicine Coping Feelings & ...

  11. Understanding Cancer Prognosis

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    Full Text Available ... Cancer Prevention Overview Screening Cancer Screening Overview Screening Tests Diagnosis & Staging Symptoms Diagnosis Staging Prognosis Treatment Types of Treatment Side Effects Clinical Trials Cancer Drugs Complementary & Alternative Medicine Coping ...

  12. Understanding Cancer Prognosis

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    Full Text Available ... Research Diagnosis and Staging Symptoms Diagnosis Staging Prognosis Questions to Ask about Your Diagnosis Research Cancer Treatment Types of Treatment Side Effects Clinical Trials Information for ...

  13. Understanding Cancer Prognosis

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    Full Text Available ... Seeking Information About Your Prognosis Is a Personal Decision When you have cancer, you and your loved ... can help you and your loved ones make decisions. Some of the decisions you may face include: ...

  14. Understanding Cancer Prognosis

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    Full Text Available ... with no treatment. So, it may not be easy for your doctor to give you an accurate ... communication share their perspectives on their cancer prognoses. Learn key points about prognosis and how to talk ...

  15. Understanding Cancer Prognosis

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    Full Text Available ... to treatment Seeking Information About Your Prognosis Is a Personal Decision When you have cancer, you and ... how long she has to live. For Doctors, a Patient-Centered Approach View this video on YouTube. ...

  16. Understanding Cancer Prognosis

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    Full Text Available ... side effects from the cancer treatments you received. Video Series This video series offers the perspectives of ... care teams (PDF-210KB). Understanding Your Cancer Prognosis Video View this video on YouTube. Three cancer patients ...

  17. Understanding Cancer Prognosis

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    Full Text Available ... Research Cancer Treatment Types of Treatment Side Effects Clinical Trials Information for Patients and Caregivers A to Z ... Staging Prognosis Treatment Types of Treatment Side Effects Clinical Trials Cancer Drugs Complementary & Alternative Medicine Coping Feelings & Cancer ...

  18. Ethno-Specific Risk Factors for Adverse Pregnancy Outcomes: Findings from the Born in Bradford Cohort Study.

    Science.gov (United States)

    Stacey, Tomasina; Prady, Stephanie; Haith-Cooper, Melanie; Downe, Soo; Simpson, Nigel; Pickett, Kate

    2016-07-01

    Objectives Preterm birth (PTB) and small for gestational age (SGA) are major causes of perinatal mortality and morbidity. Previous studies indicated a range of risk factors associated with these poor outcomes, including maternal psychosocial and economic wellbeing. This paper will explore a range of psycho-social and economic factors in an ethnically diverse population. Methods The UK's Born in Bradford cohort study recruited pregnant women attending a routine antenatal appointment at 26-28 weeks' gestation at the Bradford Royal Infirmary (2007-2010). This analysis includes 9680 women with singleton live births who completed the baseline questionnaire. Data regarding maternal socio-demographic and mental health were recorded. Outcome data were collected prospectively, and analysed using multivariate regression models. The primary outcomes measured were: PTB (order to develop appropriate targeted preventative strategies to improve perinatal outcome in disadvantaged groups, a greater understanding of ethno-specific risk factors is required. PMID:26983444

  19. Family-based risk factors for non-suicidal self-injury: Considering influences of maltreatment, adverse family-life experiences, and parent-child relational risk.

    Science.gov (United States)

    Martin, Jodi; Bureau, Jean-François; Yurkowski, Kim; Fournier, Tania Renaud; Lafontaine, Marie-France; Cloutier, Paula

    2016-06-01

    The current investigation addressed the potential for unique influences of perceived childhood maltreatment, adverse family-life events, and parent-child relational trauma on the lifetime occurrence and addictive features of non-suicidal self-injury (NSSI). Participants included 957 undergraduate students (747 females; M = 20.14 years, SD = 3.88) who completed online questionnaires regarding the key variables under study. Although self-injuring youth reported more experiences with each family-based risk factor, different patterns of association were found when lifetime engagement in NSSI or its addictive features were under study. Perceived parent-child relational trauma was uniquely linked with NSSI behavior after accounting for perceived childhood maltreatment; adverse family-life events had an additional unique association. In contrast, perceived paternal maltreatment was uniquely related with NSSI's addictive features. Findings underline the importance of studying inter-related family-based risk factors of NSSI simultaneously for a comprehensive understanding of familial correlates of NSSI behavior and its underlying features. PMID:27086083

  20. Factors Relevant to the Prognosis of Patients with Sudden Deafness after Hyperbaric Oxygen Therapy%高压氧综合治疗突发性耳聋预后相关因素分析

    Institute of Scientific and Technical Information of China (English)

    李琴; 吴嗣洪; 唐守英; 张惠华; 曹晓燕; 葛秀英

    2014-01-01

    Objective To establish a scoring model that predicts the prognosis of patients with sudden deafness after hyperbaric oxygen therapy based on clinical data and to evaluate the efficacy of the model. Methods 188 patients with sudden deafness(221 ears)who received hyperbaric oxygen therapy were divided into two groups: 168 patients(201 ears) in training group and 20 patients(20 ears)in testing group. With a self-controlled experimental design, the training group were divided into the effective group and ineffective group. Chi-square test was applied to choose statistically significant risk factors which were used to establish a scoring model. Receiver operator characteristic (ROC) curve was then used to analyze the scoring model. Results The factors that had adverse effects on the prognosis of patients with sudden deafness after hyperbaric oxygen therapy included sudden deafness with vertigo, descending/completely deaf audiogram, prehospital delay time≥15 d, hyperbaric oxygen therapy<2 courses, beginning time of treatment≥fifteen days after onset, average hearing loss at the first visit≥60 dB HL, sudden deafness with HBP(high blood pressure)/DM(diabetes mellitus)or both. The ROC curve analysis revealed that the area under the curve (AUC) for the scoring model was 0.967, which was significantly different from the AUC(0.5) under the completely random circumstances(P<0.05). The appraisal of prospective misjudge possibility was applied to the scoring model in testing samples and the results showed the misjudgement rate was about 10%. Conclusion This scoring model based on clinical data can be used to predict the prognosis of patients with sudden deafness after hyperbaric oxygen therapy.%目的:根据临床资料建立预测高压氧(hyperbaric oxygen,HBO)综合治疗突发性耳聋(sudden deafness,SD)预后的评分模型,并评价科学性。方法连续选择188例(221耳)接受高压氧综合治疗的SD患者,随

  1. 高压氧综合治疗突发性耳聋预后相关因素分析%Factors Relevant to the Prognosis of Patients with Sudden Deafness after Hyperbaric Oxygen Therapy

    Institute of Scientific and Technical Information of China (English)

    李琴; 吴嗣洪; 唐守英; 张惠华; 曹晓燕; 葛秀英

    2014-01-01

    . Receiver operator characteristic (ROC) curve was then used to analyze the scoring model. Results The factors that had adverse effects on the prognosis of patients with sudden deafness after hyperbaric oxygen therapy included sudden deafness with vertigo, descending/completely deaf audiogram, prehospital delay time≥15 d, hyperbaric oxygen therapy<2 courses, beginning time of treatment≥fifteen days after onset, average hearing loss at the first visit≥60 dB HL, sudden deafness with HBP(high blood pressure)/DM(diabetes mellitus)or both. The ROC curve analysis revealed that the area under the curve (AUC) for the scoring model was 0.967, which was significantly different from the AUC(0.5) under the completely random circumstances(P<0.05). The appraisal of prospective misjudge possibility was applied to the scoring model in testing samples and the results showed the misjudgement rate was about 10%. Conclusion This scoring model based on clinical data can be used to predict the prognosis of patients with sudden deafness after hyperbaric oxygen therapy.

  2. Prognosis and risk factors of neonatal cerebral infarction%新生儿脑梗死的预后及其危险因素

    Institute of Scientific and Technical Information of China (English)

    黄春玲; 汤泽中; 周丛乐; 侯新琳; 王红梅

    2014-01-01

    大者遗留神经系统后遗症的可能性较大.%Objective To determine the prognosis and risk factors of neonatal cerebral infarction.Methods From January 2002 to December 2010,44 newborn infants were diagnosed with cerebral infarction by imaging examinations at Peking University First Hospital.The neurodevelopmental outcomes of these newborn infants were followed up and evaluated by clinical manifestations,Gesell development scale,cranial imaging,electroencephalogram and auditory evoked potential.Factors related to prognosis were analyzed with single and multi-factor Logistic regression analysis.Results Thirty-eight (86%) cases were followed up,and of these cases,five children died and the results of three were inconclusive due to small age (less than 6 months old).Among the remaining 30 children,neurodevelopmental outcome was normal in 15 cases and abnormal in the remaining 15 cases,thus,the incidence of sequelae was 50% (15/30) and the mortality rate was 13% (5/38).Of the 15 abnormal cases,all had cerebral palsy and movement retardation,eight cases had cognitive impairment,eight cases had epilepsy and five had visual impairment.The incidence of large cerebral infarction (more than one lobe) was 14/15,worse cranial imaging outcome (one month after treatment,cerebral infarction lesion still present or had expanded)was 13/15,and severe complications was 8/15 in the newborns with sequelae,which were higher than in those without sequelae (4/15,5/15 and 1/15,respectively) (x2=13.889,8.889 and 7.778,all P<0.05).Logistic regression analysis showed that large cerebral infarction was a risk factor for sequelae (OR=38.500,95%C1:3.749-395.407,P=0.002),however,worse cranial imaging outcome (OR=8.563,95%CI:0.909-80.683,P=0.061) and severe complications (OR=18.024,95%CI:0.516-630.163,P=0.111) were not risk factors for sequelae.Cerebral infarction with middle cerebral artery injury had a high risk of movement retardation (OR=6.000,95%CI:1.172-3.725,P=0

  3. Metastatic lymph node ratio, 6th or 7th AJCC edition: witch is the best lymph node classification for esophageal cancer? Prognosis factor analysis in 487 patients

    OpenAIRE

    CORAL, Roberto V.; BIGOLIN, André V.; CORAL, Roberto P.; Hartmann, Antonio; DRANKA, Carolina; ROEHE, Adriana V.

    2015-01-01

    Background The esophageal cancer is one of the most common and aggressive worldwide. Recently, the AJCC changed the staging system, considering, among others, the important role of the lymph node metastasis on the prognosis. Aim To discuss the applicability of different forms of lymph node staging in a western surgical center. Methods Four hundred eighty seven patients with esophageal cancer were enrolled. Three staging systems were evaluated, the 6th and the 7th AJCC editions and the Lymph N...

  4. Analysis of Prognosis of Insomnia and Its Influence Factors%失眠的预后及影响因素分析

    Institute of Scientific and Technical Information of China (English)

    蒋尚融; 王传刘; 林子江; 敖文玲; 何金彩

    2012-01-01

    Objective To investigate the general conditions and prognosis factors for patients with insomnia. Methods The questionnaire self-made in accordance with the Consensus on definition and treatment in insomnia (draft) was used in the Sleep Center of First Affiliated Hospital of Wenzhou Medical College for the investgation on patients newly diagnosed with insomnia from Aug to Sept, 2007. All the patients were subjected to the individualized drug therapy which was supplemented with dormancy hygiene education, and then a telephone follow - up after 6 months. The process was targeted at observing the relationship of the disease outcome with drug compliance and dormancy hygiene education. Results A total of 123 patients completed the investigation. It was found that these insomnia patients mainly included female patients,chronic insomnia patients,patients aged 31 -40 years,mental workers,and patients with insomnia combined with mild or anxiety - free depression. Most had inducing factors that maily were stress events in the life. Patients adhering to dormancy hygiene advice and having good drug compliance produced a better outcome and the results were significant difference (P < 0.05 ). Conclusion Chronic insomnia patients,female patients,31 -40 years old patients,mental working patients and so on account for the majority, and the better outcome may be attributable to the dormancy health education and drug compliance improvement.%目的 调查失眠患者一般情况以及预后影响因素.方法 自制问卷,按照《中国失眠定义、诊断及药物治疗专家共识(草案)》,对2007年8~9月温州医学院附属第一医院睡眠中心初诊失眠患者进行调查,所有患者采用个体化药物治疗辅以睡眠卫生宣教,6个月后进行电话随访,观察患者病情转归与药物依从性以及睡眠卫生宣教的关系.结果 共有123例患者完成调查,发现其中以女性患者、慢性失眠、31~40岁患者、脑力劳动者、合并轻度

  5. Adverse effect of plasma exchange on anti-D production in rhesus immunisation owing to removal of inhibitory factors.

    OpenAIRE

    Barclay, G. R.; Greiss, M A; Urbaniak, S J

    1980-01-01

    Intensive plasma exchange was used to reduce the maternal anti-D concentration in case of severe rhesus haemolytic disease. Initially the concentration fell from 30 to 4 IU/ml, but after six exchanges it increased to 490 IU/ml despite continued exchanges, and intrauterine fetal death eventually ensued. The increase in the rate of maternal anti-D production coincided with, and may have resulted from, removal of plasma immuno-regulatory factors that inhibited in-vitro lymphocyte functions. Thes...

  6. Related risk factors of short-term prognosis in patients with viral encephalitis%影响病毒性脑炎近期预后的相关危险因素分析

    Institute of Scientific and Technical Information of China (English)

    蔡高梅

    2011-01-01

    Objective To investigate the risk factors of short-term prognosis in patients with viral encephalitis. Methods Clinical data of 124 patients with viral encephalitis were analyzed retrospectively. All patients were divided into good prognosis group and poor prognosis group according to the Glasgow outcome scale. Fourteen related risk factors were chosen and multifactor Logistic regression analysis was made. Results Univariate analysis showed, the duration of seizure, consciousness disorder, deficiency of cranial nerves, severe abnormal electroencephalogram and abnormal cranial MRI had significant correlation with short-term prognosis (P<0.05), but age, sex,behavior disorder, meningeal irritation sign, pressure of cerebrospinal fluid (CSF), leukocyte number of CSF, protein level of CSF, peripheral white blood cell, and abnormal cranial CT had no correlation with short-term prognosis (P >0.05). Multivariate analysis showed that the abnormal of cranial MRI and the duration of seizure were the independent risk factors of short-term prognosis. Conclusions The short-term prognosis of viral encephalitis relates with many factors. The abnormal cranial MRI and the duration of seizure are the important related risk factors.%目的 探讨影响病毒性脑炎近期预后的相关危险因素.方法 回顾性分析124例病毒性脑炎患者的临床资料,应用格拉斯哥预后量表(COS)分级将患者分为预后良好组(89例)和预后不良组(35例).并选取14个危险因素进行Logistic回归分析.结果 单因素分析表明,抽搐持续时间、意识障碍、局灶性神经功能缺损,头颅MRI异常、脑电图重度异常与病毒性脑炎近期预后有显著相关性(P<0.05);而年龄、性别、精神行为异常、脑膜刺激征、脑脊液(CSF)压力、CSF白细胞数、CSF蛋白、外周血白细胞计数、头颅CT异常与病毒性脑炎近期预后无显著相关性(P>0.05).多因素分析表明,抽搐持续时间(OR=2.877,P=0.005)

  7. Analysis of prognosis-related factors for severe acute pancreatitis%重症急性胰腺炎预后的早期相关因素分析

    Institute of Scientific and Technical Information of China (English)

    沈阳; 许春舫

    2011-01-01

    目的探讨重症急性胰腺炎(severe acute pancreatitis,SAP)患者入院24 h内与预后的相关因素.方法 对193例SAP患者临床资料作回顾性分析.按预后分为死亡组和存活组,先以单因素分析筛选有统计学意义的影响因素,再通过Logistic回归分析筛选与预后有关的影响因素.结果 SAP死亡组患者年龄、血钙、阴离子间隙、血浆总蛋白、血清白蛋白、肌酐、尿素氮与存活组患者比较差异有统计学意义(P0.05).Logistic回归分析显示早期血肌酐、血清总蛋白浓度与SAP预后存在相关性(P<0.05).结论 入院24h内的血肌酐、血清总蛋白浓度是影响SAP预后的早期因素.%Objective To investigate the prognosis - related factors for severe acute pancreatitis within 24 hours after admission. Methods A total of 193 consecutive patients of severe acute pancreatitis were studied retrospectively. According to the prognosis, they were divided into the death group and the survival group. Seek for the prognosis - related factors by means of univariate analysis, and then by logistic regression analysis. Results There were of significant differences in average age, anion gap, total plasma protein, serum albumin, creatinine, usea nitrogen of the two groups (P < 0. 05) , whereas there were not of significant differences in gender, etiology, hematocrit, white blood cell count, platelet count, oxygen partial pressure, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactate dehydrogenase of the two groups(P > 0. 05). Creatinine and total plasma protein were associated with the prognosis of severe acute pancreatitis by logistic regression analysis(P < 0. 05). Conclusion The concentration of reatinine and total plasma protein within 24 hours after admission were the prognosis - related factors for severe acute pancreatitis.

  8. Deregulation of COMMD1 Is Associated with Poor Prognosis in Diffuse Large B-cell Lymphoma

    DEFF Research Database (Denmark)

    Taskinen, M.; Louhimo, R.; Koivula, S.;

    2014-01-01

    Background: Despite improved survival for the patients with diffuse large B-cell lymphoma (DLBCL), the prognosis after relapse is poor. The aim was to identify molecular events that contribute to relapse and treatment resistance in DLBCL. Methods: We analysed 51 prospectively collected pretreatment...... associated with unfavourable survival. The 2p15 aberration harboured COMMD1 gene, whose expression had a significant adverse prognostic impact on survival. Immunohistochemical analysis of COMMD1 expression in two series confirmed the association of COMMD1 expression with poor prognosis. Conclusion: COMMD1 is...... a potential novel prognostic factor in DLBCLs. The results highlight the value of integrated comprehensive analysis to identify prognostic markers and genetic driver events not previously implicated in DLBCL....

  9. Reproductive prognosis in endometriosis

    DEFF Research Database (Denmark)

    Hjordt Hansen, Maj V; Dalsgaard, Torur; Hartwell, Dorthe;

    2014-01-01

    OBJECTIVE: To assess the reproductive long-term prognosis of women with and without endometriosis, to explore changes over time, and to quantify the contribution of artificial reproductive techniques. DESIGN: Cohort study. SETTING: Denmark 1977-2009. SAMPLE: Data retrieved from four national...... registries. Among 15-49-year-old women during the period 1977-82, 24 667 were diagnosed with endometriosis and 98 668 (1:4) women without endometriosis were age-matched. METHODS: To assess long-term reproductive prognosis, all pregnancy outcomes were identified among the women with and without endometriosis...

  10. Extent of poly-pharmacy, occurrence and associated factors of drug-drug interaction and potential adverse drug reactions in Gondar Teaching Referral Hospital, North West Ethiopia

    Directory of Open Access Journals (Sweden)

    Endalkachew Admassie

    2013-01-01

    Full Text Available The aim of this study was to assess the extent of poly-pharmacy, occurrence, and associated factors for the occurrence of drug-drug interaction (DDI and potential adverse drug reaction (ADR in Gondar University Teaching Referral Hospital. Institutional-based retrospective cross-sectional study. This study was conducted on prescriptions of both in and out-patients for a period of 3 months at Gondar University Hospital. Both bivariate analysis and multivariate logistic regression were used to identify risk factors for the occurrence of DDI and possible ADRs. All the statistical calculations were performed using SPSS; software. A total of 12,334 prescriptions were dispensed during the study period of which, 2,180 prescriptions were containing two or more drugs per prescription. A total of 21,210 drugs were prescribed and the average number of drugs per prescription was 1.72. Occurrences of DDI of all categories (Major, Moderate, and Minor were analyzed and DDI were detected in 711 (32.6% prescriptions. Sex was not found to be a risk factor for the occurrence of DDI and ADR, while age and number of medications per prescription were found to be significant risk factors for the occurrence of DDI and ADR. The mean number of drugs per prescription was 1.72 and hence with regard to the WHO limit of drugs per prescription, Gondar hospital was able to maintain the limit and prescriptions containing multiple drugs supposed to be taken systemically. Numbers of drugs per prescription as well as older age were found to be predisposing factors for the occurrence of DDI and potential ADRs while sex was not a risk factor.

  11. Fertility prognosis for infertile couples

    DEFF Research Database (Denmark)

    Bostofte, E; Bagger, P; Michael, A;

    1993-01-01

    OBJECTIVE: To develop a fertility prognosis model for infertile couples. DESIGN: Prospective follow-up study. PARTICIPANTS: In the period November 30, 1977 to June 1, 1985, 321 consecutive couples were investigated for infertility at Hvidovre University Hospital. Investigation of the female...... MEASURE: The Cox regression model was used to predict the time required to conceive based on informations provided by fertility investigations. RESULTS: Three of 16 prognostic variables (the period of infertility, the female infertility factor, and the P-test) possess significant prognostic information...

  12. Clinical study of different risk factors on prognosis among chronic heart failure patients of different genders%慢性心力衰竭患者性别差异对预后的影响因素研究

    Institute of Scientific and Technical Information of China (English)

    褚松筠; 彭芬; 赵静; 李葚煦; 崔晓静; 刘琳; 丁文惠

    2014-01-01

    Objective Serial follow-up study was conducted in chronic heart failure cohort of our center .Etiology ,comorbidity ,clinical characteristics of these patients and the incidence of adverse events were analyzed ,focusing on the influence of gender difference of risk factors .Methods Consecutive 228 patients diagnosed as chronic heart failure were enrolled .History ,physical exam-ination findings ,lab and ultrasonographicdata were collected .Average follow-up were 23 .6 ± 6.5 months .End points were defined as re-admission of heart failure ,death of cardiac origin ,and all-cause death .The risk factors of female and male patients were analyzed and compared .Results No significant difference of these prognostic events was detected between genders .However ,fe-male patients were older than males ,complicated with more hypertension ,atrial fibrillation ,chron-ic kidney disease ,and diastolic dysfunction (P<0 .01) .In females ,atrial fibrillation was an inde-pendent risk factor of recurrence of decompensated heart failure (OR=6 .874 ,95% CI:1 .932 -24.459 ,P=0 .003);low LVEF and high pulmonary artery pressure in acute phase independently predicted deaths of cardiac origin (OR=0 .917 ,95% CI:0 .851 -0 .989 ,P=0 .024 ;OR= 1 .107 , 95% CI:1 .021-1 .200 ,P=0 .013);NYHA functional class in chronic phase independently predic-ted all-cause deaths (OR=12 .484 ,95% CI:1 .117 -139 .495 ,P= 0 .040) .Conclusion Different risk factors of adverse prognosis were found between genders .Optimization of management on at-rial fibrillation and diastolic heart failure are more meaningful among females .%目的:对慢性心力衰竭(心衰)患者进行随访,评估其病因、合并疾病、临床特征与心衰预后指标的相关性,分析性别差异对患者预后影响的相关危险因素。方法连续纳入慢性心衰患者228例,每3个月门诊随访,收集临床资料、心脏超声参数等。记录患者心衰再入院、心源性死亡以及全因死亡终点

  13. A systematic review of the prevalence and risk factors for adverse drug reactions in the elderly in the acute care setting

    Directory of Open Access Journals (Sweden)

    Alhawassi TM

    2014-12-01

    Full Text Available Tariq M Alhawassi,1,2 Ines Krass,1 Beata Bajorek,3,4 Lisa G Pont5 1Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia; 2College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 3Graduate School of Health – Pharmacy, University of Technology Sydney, 4Pharmacy Department, Royal North Shore Hospital, 5Sydney Nursing School, University of Sydney, Sydney, NSW, Australia Abstract: Adverse drug reactions (ADRs are an important health issue. While prevalence and risk factors associated with ADRs in the general adult population have been well documented, much less is known about ADRs in the elderly population. The aim of this study was to review the published literature to estimate the prevalence of ADRs in the elderly in the acute care setting and identify factors associated with an increased risk of an ADR in the elderly. A systematic review of studies published between 2003 and 2013 was conducted in the Cochrane Database of Systematic Reviews, EMBASE, Google Scholar and MEDLINE. Key search terms included: “adverse drug reactions”, “adverse effects”, “elderly patients and hospital admission”, “drug therapy”, “drug adverse effects”, “drug related”, “aged”, “older patients”, “geriatric”, “hospitalization”, and “emergency admissions”. For inclusion in the review, studies had to focus on ADRs in the elderly and had to include an explicit definition of what was considered an ADR and/or an explicit assessment of causality, and a clear description of the method used for ADR identification, and had to describe factors associated with an increased risk of an ADR. Fourteen hospital-based observational studies exploring ADRs in the elderly in the acute care setting were eligible for inclusion in this review. The mean prevalence of ADRs in the elderly in the studies included in this review was 11.0% (95% confidence interval [CI]: 5.1%–16.8%. The median prevalence of ADRs leading to

  14. The relationship between nuclear factor (NF)-κB family gene expression and prognosis in triple-negative breast cancer (TNBC) patients receiving adjuvant doxorubicin treatment.

    Science.gov (United States)

    Kim, Ji-Yeon; Jung, Hae Hyun; Ahn, Soomin; Bae, SooYoun; Lee, Se Kyung; Kim, Seok Won; Lee, Jeong Eon; Nam, Seok Jin; Ahn, Jin Seok; Im, Young-Hyuck; Park, Yeon Hee

    2016-01-01

    We investigated gene expression profiles of the NF-κB pathway in patients with triple-negative breast cancer (TNBC) receiving adjuvant chemotherapy to determine the prognostic value of NF-κB pathway genes according to chemotherapeutic regimen. We used the nCounter expression assay to measure expression of 11 genes (NFKB1, NFKB2, RELA, RELB, REL, TP53, FOXC1, TBP, SP1, STAT3 and IRF1 genes) belonging to the NF-κB pathway using mRNA extracted from paraffin-embedded tumor tissues from 203 patients diagnosed with TNBC. Of the 203 patients, 116 were treated with a chemotherapeutic regimen containing doxorubicin. As revealed by the expression profiles of the 11 genes, increased expression of SP1 was associated with poor prognosis in TNBC patients treated with adjuvant doxorubicin chemotherapy (5-year distant recurrence-free survival [5Y DRFS], low vs. high expression [cut-off: median]: 92.3% vs. 71.6%, P = 0.001). In a multivariate Cox regression model, SP1 expression was a useful marker for predicting long-term prognosis in TNBC patients receiving doxorubicin treatment, and we thus suggest that SP1 expression could serve as a prognostic marker in these patients. PMID:27545642

  15. The relationship between nuclear factor (NF)-κB family gene expression and prognosis in triple-negative breast cancer (TNBC) patients receiving adjuvant doxorubicin treatment

    Science.gov (United States)

    Kim, Ji-Yeon; Jung, Hae Hyun; Ahn, Soomin; Bae, SooYoun; Lee, Se Kyung; Kim, Seok Won; Lee, Jeong Eon; Nam, Seok Jin; Ahn, Jin Seok; Im, Young-Hyuck; Park, Yeon Hee

    2016-01-01

    We investigated gene expression profiles of the NF-κB pathway in patients with triple-negative breast cancer (TNBC) receiving adjuvant chemotherapy to determine the prognostic value of NF-κB pathway genes according to chemotherapeutic regimen. We used the nCounter expression assay to measure expression of 11 genes (NFKB1, NFKB2, RELA, RELB, REL, TP53, FOXC1, TBP, SP1, STAT3 and IRF1 genes) belonging to the NF-κB pathway using mRNA extracted from paraffin-embedded tumor tissues from 203 patients diagnosed with TNBC. Of the 203 patients, 116 were treated with a chemotherapeutic regimen containing doxorubicin. As revealed by the expression profiles of the 11 genes, increased expression of SP1 was associated with poor prognosis in TNBC patients treated with adjuvant doxorubicin chemotherapy (5-year distant recurrence-free survival [5Y DRFS], low vs. high expression [cut-off: median]: 92.3% vs. 71.6%, P = 0.001). In a multivariate Cox regression model, SP1 expression was a useful marker for predicting long-term prognosis in TNBC patients receiving doxorubicin treatment, and we thus suggest that SP1 expression could serve as a prognostic marker in these patients. PMID:27545642

  16. Brief depression screening with the PHQ-2 associated with prognosis following percutaneous coronary intervention with paclitaxel-eluting stenting

    DEFF Research Database (Denmark)

    Pedersen, Susanne S.; Denollet, Johan; de Jonge, Peter; Simsek, Cihan; Serruys, Patrick W; van Domburg, Ron T

    2009-01-01

    Depression is associated with adverse prognosis in cardiac patients, warranting the availability of brief and valid instruments to identify depressed patients in clinical practice.......Depression is associated with adverse prognosis in cardiac patients, warranting the availability of brief and valid instruments to identify depressed patients in clinical practice....

  17. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Your Diagnosis Research Understanding Cancer Prognosis Oncologist Anthony L. Back, M.D., a national expert on doctor- ... YouTube. Three cancer patients and their doctor, Anthony L. Back, M.D. -- an oncologist who is also ...

  18. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Diagnosis Staging Prognosis Treatment Types of Treatment Side Effects Clinical Trials Cancer Drugs Complementary & Alternative Medicine Coping Feelings & Cancer Adjusting to Cancer Self Image & Sexuality Day to Day Life Survivorship For Family & Friends Questions to Ask About Cancer Advanced Cancer ...

  19. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... your loved ones make decisions. Some of the decisions you may face include: Which treatment is best for you If you want treatment How to best take care of yourself and manage treatment side effects How to deal with financial and legal matters Many people want to know their prognosis. ...

  20. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... tell her how long she has to live. For Doctors, a Patient-Centered Approach View this video on YouTube. Anthony L. Back, M.D., coaches other oncologists about how to discuss prognosis with their patients. Good communication, he says, is part of providing good care. ...

  1. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Your Cancer Prognosis Video View this video on YouTube. Three cancer patients and their doctor, Anthony L. ... One Couple's Creative Response View this video on YouTube. Vanessa, an artist, and her husband Roy discover ...

  2. Symposium summary and prognosis

    International Nuclear Information System (INIS)

    The summary of the symposium on high energy physics experiments includes phenomena at low energies, the foundations of physics (considered to be mainly gravitation and quantum electrodynamics), standards of reference used for interpretation of experimental data, the new physics, particle proliferation, theoretical development, and a prognosis for the future

  3. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... before cancer How you respond to treatment Seeking Information About Your Prognosis Is a Personal Decision When ... Twitter Instagram YouTube Google+ LinkedIn GovDelivery RSS CONTACT INFORMATION Contact Us LiveHelp Online Chat MORE INFORMATION About ...

  4. Post-marketing surveillance of the safety profile of iodixanol in the outpatient CT setting. A prospective, multicenter, observational study of patient risk factors, adverse reactions and preventive measures in 9953 patients

    International Nuclear Information System (INIS)

    Non-interventional study in outpatient, contrast-enhanced CT: 1. to determine the extent of preventive measures for risk reduction of adverse drug reactions after contrast-enhanced CT examinations. 2. to prospectively determine the incidence and severity of adverse drug reactions occurring after administration of the iso-osmolar contrast medium iodixanol. 3. to determine a possible influence of preventive measures on the incidence/severity of adverse drug reactions. Evaluable documentation was provided for 9953 patients from 66 radiology centers across Germany. Patient characteristics, aspects of iodixanol administration, and adverse events with an at least 'possible' relationship were documented on a standardized case report form (CRF) and were evaluated up to seven days after contrast medium administration. About 55.5% of patients showed one or more risk factors (e.g. impaired renal function 4.4%, diabetes mellitus 8.5%, hypertension 20.6%). One third of the sites did not implement any preventive measures. Patients with a known risk for an allergy-like reaction were more likely to receive pharmacologic preventive treatment (0.5-50.5%). Oral hydration was the main preventive measure in patients with renal risk factors (<8%) followed by intravenous hydration (1%). Adverse drug reactions, mainly hypersensitivity reactions, occurred in 77 patients (0.74%), but were classified as serious in only 3 patients (0.03%). No statistically significant correlation between risk factors, preventive measures, and adverse reactions could be found. The use of preventive measures for CT examinations in this outpatient setting was generally low with risk patients being pre-medicated more often, depending on their history. In the routine outpatient setting, iso-osmolar iodixanol was very well tolerated in almost 10 000 patients undergoing diagnostic CT. The rate of acute and delayed adverse reactions was low. No correlation could be found between risk factors, preventive measures and

  5. Post-marketing surveillance of the safety profile of iodixanol in the outpatient CT setting. A prospective, multicenter, observational study of patient risk factors, adverse reactions and preventive measures in 9953 patients

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Frank Hugo Heinz [Radiology and Nuclear Medicine Center, Ludwigshafen (Germany)

    2014-11-15

    Non-interventional study in outpatient, contrast-enhanced CT: 1. to determine the extent of preventive measures for risk reduction of adverse drug reactions after contrast-enhanced CT examinations. 2. to prospectively determine the incidence and severity of adverse drug reactions occurring after administration of the iso-osmolar contrast medium iodixanol. 3. to determine a possible influence of preventive measures on the incidence/severity of adverse drug reactions. Evaluable documentation was provided for 9953 patients from 66 radiology centers across Germany. Patient characteristics, aspects of iodixanol administration, and adverse events with an at least 'possible' relationship were documented on a standardized case report form (CRF) and were evaluated up to seven days after contrast medium administration. About 55.5% of patients showed one or more risk factors (e.g. impaired renal function 4.4%, diabetes mellitus 8.5%, hypertension 20.6%). One third of the sites did not implement any preventive measures. Patients with a known risk for an allergy-like reaction were more likely to receive pharmacologic preventive treatment (0.5-50.5%). Oral hydration was the main preventive measure in patients with renal risk factors (<8%) followed by intravenous hydration (1%). Adverse drug reactions, mainly hypersensitivity reactions, occurred in 77 patients (0.74%), but were classified as serious in only 3 patients (0.03%). No statistically significant correlation between risk factors, preventive measures, and adverse reactions could be found. The use of preventive measures for CT examinations in this outpatient setting was generally low with risk patients being pre-medicated more often, depending on their history. In the routine outpatient setting, iso-osmolar iodixanol was very well tolerated in almost 10 000 patients undergoing diagnostic CT. The rate of acute and delayed adverse reactions was low. No correlation could be found between risk factors, preventive

  6. Urinary Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) • Insulin-Like Growth Factor-Binding Protein 7 (IGFBP7) Predicts Adverse Outcome in Pediatric Acute Kidney Injury

    Science.gov (United States)

    Westhoff, Jens H.; Tönshoff, Burkhard; Waldherr, Sina; Pöschl, Johannes; Teufel, Ulrike; Westhoff, Timm H.; Fichtner, Alexander

    2015-01-01

    Background The G1 cell cycle inhibitors tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been identified as promising biomarkers for the prediction of adverse outcomes including renal replacement therapy (RRT) and mortality in critically ill adult patients who develop acute kidney injury (AKI). However, the prognostic value of urinary TIMP-2 and IGFBP7 in neonatal and pediatric AKI for adverse outcome has not been investigated yet. Methods The product of the urinary concentration of TIMP-2 and IGFBP7 ([TIMP-2]•[IGFBP7]) was assessed by a commercially available immunoassay (NephroCheck™) in a prospective cohort study in 133 subjects aged 0–18 years including 46 patients with established AKI according to pRIFLE criteria, 27 patients without AKI (non-AKI group I) and 60 apparently healthy neonates and children (non-AKI group II). AKI etiologies were: dehydration/hypovolemia (n = 7), hemodynamic instability (n = 7), perinatal asphyxia (n = 9), septic shock (n = 7), typical hemolytic-uremic syndrome (HUS; n = 5), interstitial nephritis (n = 5), vasculitis (n = 4), nephrotoxic injury (n = 1) and renal vein thrombosis (n = 1). Results When AKI patients were classified into pRIFLE criteria, 6/46 (13%) patients fulfilled the criteria for the category “Risk”, 13/46 (28%) for “Injury”, 26/46 (57%) for “Failure” and 1/46 (2%) for “Loss”. Patients in the “Failure” stage had a median 3.7-fold higher urinary [TIMP-2]•[IGFBP7] compared to non-AKI subjects (P<0.001). When analyzed for AKI etiology, highest [TIMP-2]•[IGFBP7] values were found in patients with septic shock (P<0.001 vs. non-AKI I+II). Receiver operating characteristic (ROC) curve analyses in the AKI group revealed good performance of [TIMP-2]•[IGFBP7] in predicting 30-day (area under the curve (AUC) 0.79; 95% CI, 0.61–0.97) and 3-month mortality (AUC 0.84; 95% CI, 0.67–0.99) and moderate performance in predicting RRT

  7. Analysis of related factors concerning prognosis in patients with delayed encephalopathy after carbon monoxide poisoning%一氧化碳中毒迟发性脑病患者预后相关因素分析

    Institute of Scientific and Technical Information of China (English)

    高宇; 高春锦; 王铁; 葛环; 杨晶; 宋振国

    2013-01-01

    目的 分析一氧化碳中毒迟发性脑病患者预后的相关因素,为临床更好地判断一氧化碳中毒迟发性脑病预后提供依据.方法 一氧化碳中毒迟发性脑病患者52例,详细记录预后可能的相关因素,包括性别、年龄、昏迷时间、假愈期、一氧化碳中毒后是否行高压氧治疗,有无高血压、糖尿病病史,并在迟发性脑病高峰期进行生活自理能力评分及脑葡萄糖代谢测定.结果 影响一氧化碳中毒迟发性脑病患者临床预后的3个独立因素分别为性别、年龄和迟发性脑病假愈期时间(P<0.05).结论 一氧化碳中毒迟发性脑病的预后与性别、年龄及假愈期时间有关,脑葡萄糖代谢值尚不能作为预测迟发性脑病预后的指标.%Objective To analyze related factors concerning prognosis in patients with delayed encephalopathy after carbon monoxide poisoning,and to provide clinical evidence for better assessment of prognosis of delayed encephalopathy after carbon monoxide poisoning.Methods Fifty-two cases of delayed encephalopathy after carbon monoxide poisoning were enrolled in our study.Such related factors as gender,age,duration of coma,false lucid interval time,HBO therapy,blood pressure and history of diabetes were all recorded in detail.Scores of activities of daily living (ADL) at the peak of delayed encephalopathy were recorded and cerebral glucose metabolism was monitored.Results The 3 independent factors affecting the clinical outcome of patients with delayed encephalopathy after carbon monoxide poisoning were gender,age and false lucid interval time (P < 0.05).Conclusions The prognosis of delayed encephalopathy was associated with gender,age,and false lucid interval time,the value of cerebral glucose metabolism could not be used as an index for predicting the prognosis of delayed encephalopathy.

  8. Adverse trends of cardiovascular risk factors among low risk populations (1983-1994 - a cohort study of workers and farmers in Guangzhou, China

    Directory of Open Access Journals (Sweden)

    Liu Xiaoqing

    2011-12-01

    Full Text Available Abstract Background The levels and trends of cardiovascular risk factors vary greatly throughout China. We examine 10-year trends of cardiovascular risk factors (1983-1994 and the factors related to these trends among low-risk cohorts of workers and farmers in Guangzhou, China. Methods This is a cohort study of 3,131 workers and 3,493 farmers aged 25-64 years at baseline with 10 years of follow-up. We performed a longitudinal analysis to account for the aging of the cohorts and the repeated measures of the same individual. Results At baseline the prevalence of overweight (including obese ranged from 1.0% to 11.8%, hypertension ranged from 3.8% to 10.5%, and mean serum total cholesterol (TC ranged from 155.4 mg/dl to 187.2 mg/dl. Although prevalence of smoking declined, blood pressure levels and body mass index (BMI increased significantly, and lipid profiles changed unfavorably during the 10-year follow-ups. The prevalence of hypertension increased from 5.0 percentage points (female farmers to 12.3 percentage points (male farmers. Mean TC increased significantly (e.g., +22.8 mg/dl and +17.0 mg/dl in male and female farmers, respectively. In the longitudinal data analyses, increase in BMI was associated with increase in blood pressure levels and TC. Significant adverse trends of risk factors persisted after adjustment for aging, education, BMI, smoking, and alcohol intake. Conclusion Urgent action is needed to prevent and reverse the unhealthy trends occurring among these low risk Chinese workers and farmers.

  9. Clinical severity and prognosis of hand eczema

    DEFF Research Database (Denmark)

    Hald, M; Agner, T; Blands, J;

    2009-01-01

    to identify factors associated with severe disease and a poor prognosis. METHODS: Study participants were 799 patients with HE from nine dermatological clinics in Denmark. Severity assessment of the HE was done at baseline and at the 6-month follow-up using the Hand Eczema Severity Index (HECSI) and......BACKGROUND: Hand eczema (HE) is a frequent, long-lasting disease with both personal and societal repercussions. Consequently, more information is needed on factors that maintain symptoms. OBJECTIVES: In this study, patients with HE were followed for 6 months from the first visit to a dermatologist...... unskilled worker was a predictor for a poor prognosis at follow-up (P = 0.04), and the presence of frequent symptoms during the previous 12 months was associated with severe initial disease (P = 0.02) and a poor prognosis (P = 0.04). CONCLUSIONS: Overall, the disease had improved 6 months after the...

  10. Understanding Your Cancer Prognosis Video

    Science.gov (United States)

    Understanding Your Cancer Prognosis is the main video in the NCI Prognosis Video Series, which offers the perspectives of three cancer patients and their doctor, an oncologist who is also a national expert in doctor-patient communication.

  11. 不良妊娠结局现状及其影响因素分析%Current status of adverse pregnancy outcomes and their influencing factors

    Institute of Scientific and Technical Information of China (English)

    李媛媛; 张海鲲; 李忠良; 张成元

    2014-01-01

    目的:了解不良妊娠结局的现状并探讨其主要影响因素。方法随机抽取山东省潍坊市2家医院2012年5月至2013年5月期间就诊的孕产妇共计698人,通过查阅产妇病例、新生儿出生记录、现场询问和随访获得产妇和新生儿父亲的一般情况、孕期及分娩情况等资料,应用多因素Logistic回归分析筛选妊娠结局的主要影响因素。结果不良妊娠结局的发生率为15.09%;产妇营养状况好为妊娠结局的保护性因素(OR=2.28,95%CI:1.47~3.54,P<0.05);而高龄产妇、有长期服药史、产妇异常孕产史、妊娠合并症、细菌或病毒性感染、有害因素接触史、羊水异常、胎盘异常等8个因素为妊娠结局的危险因素(均P<0.05)。结论鼓励育龄妇女在最佳生育年龄段生育;注意孕期营养均衡;减少农药等有害因素的接触;加强孕期及分娩时的健康监护工作,特别是注意预防感染和妊娠合并症,防止胎盘异常和羊水异常等。%Objective To investigate the current status of adverse pregnancy outcomes and their major influencing factors .Methods Totally 698 pregnant women visiting hospital were randomly selected from 2 hospitals in Shandong Weifang from May 2012 to May 2013.The general situation of newborns ’ mother and father , pregnancy and delivery data were obtained through maternal clinical records , birth records, on-the-spot inquiry and follow-up.Multiple logistic regression analysis was conducted to screen the major influencing factors of pregnancy outcomes .Results The incidence of adverse pregnancy outcomes was 15.09%.Good maternal nutritional status was protective factor of pregnancy outcomes (OR=2.28, 95%CI:1.47-3.54, P<0.05).Risk factors included advanced maternal age , long-term medication history , maternal history of abnormal pregnancy , pregnancy complications , bacterial or viral infection , history of exposure to harmful

  12. PROGNOSIS OF DEPRESSION

    OpenAIRE

    Sachdev, S.; Nandi, D. N.; Mukherjee, S. P.

    1983-01-01

    SUMMARY Relationship of different symptoms, personal history, some measures of Rorschach, neuroticism, ego strength score with prognosis of depression was studied. Out of 60 items studied in 60 cases, eleven were found to have statistically significant association with improvement. Multiple regression of percentage of improvement on 23 items (12 from personal and family history and 13 measurable items of Rorschach) was determined. To check the ability of this multiple regression to expl. in d...

  13. The Prognosis of Patients with Chronic Kidney Disease and Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Vladu Mihaela

    2014-09-01

    Full Text Available Background and Aims: Diabetes mellitus (DM is a chronic disease which can evolve towards devastating micro and macro-vascular complications. Chronic kidney disease (CKD is a worldwide public health problem, with adverse outcomes of kidney failure, cardiovascular disease (CVD and premature death. The aim of our study was to evaluate the prognosis in patients with DM and CKD, depending on estimated glomerular filtration rate (eGFR and albuminuria, according to the classification of Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (KDIGO from 2013 Materials and Methods: The study was epidemiological, transversal, non interventional type, with 600 subjects unselected patients divided into three subgroups: 200 patients with T1DM, 200 patients with T2DM and 200 age matched subjects without DM. The recorded data have been analyzed using the Statistic Package for Social Sciences (SPSS, the 17.00 software (IBM Corporation, Armonk, NY, United States of America. Results:. We found a statistically significant difference among the three study groups (p < 0.0001 regarding the prognosis of CKD. Conclusions: DM represents an important risk factor for the appearance of CKD but also a negative prognosis factor for the patients with CKD.

  14. 早产儿肺透明膜病发病及预后的高危因素分析%Analysis on the high risk factors of pathogenesis and prognosis with hyaline membrane disease in premature infant

    Institute of Scientific and Technical Information of China (English)

    朱良梅; 李晓春; 孔少云; 汪敏慧

    2014-01-01

    Objective: To discuss the high risk factors of pathogenesis and prognosis with hyaline membrane disease in premature infant, and to provide preventive measures for hyaline membrane disease in premature infant. Methods: 67 children who were confirmed hyaline membrane disease were chosen as the objects of the research, as the same time in the hospital,1194 premature infants were allocated into control groups, the high risk factors of pathogenesis and prognosis with HMD would be retrospective analysis. Results: Asphyxia in perinatal period, placenta previa, placental abruption, small gestational age, low-body weight was the high risk factors of the happening of HMD, but premature rupture of membranes and antenatal glucocorticoids were preventions for HMD. The smaller of the gestational age and the lower of the weight, the prognosis of HMD were the worse. In the early stage, using the pulmonary surfactants could improve the survival rates of HMD. Conclusion: Pregnant woman, especially high risk pregnant women should attach importance to prenatal examination, find problems in time and correctly dispose, eliminate the high risk factors of HMD, reduce the premature infants, treat actively, and reduce the morbidities and the case fatality rates of HMD.%目的:探讨早产儿肺透明膜病(HMD)发病及影响预后的高危因素,为新生儿肺透明膜病发病提供预防措施。方法:选择67例HMD患儿为研究对象,同期住院的1194例早产儿为对照组,回顾性分析与HMD发病及预后有关的危险因素。结果:围生期窒息、前置胎盘、胎盘早剥、小胎龄、低体重为早产儿HMD发生的高危因素,而胎膜早破及产前使用糖皮质激素对HMD有预防作用。而胎龄越小、体重越低HMD预后越差,早期使用肺表面活性物质明显提高HMD存活率。结论:对孕母特别是高危妊娠孕母重视产前检查,及时发现问题并予以正确处理,减少早产,积极消除HMD高危

  15. Prognosis of primary liver carcinoma treated with local resection

    Institute of Scientific and Technical Information of China (English)

    蔡建强; 胡敬群; 车旭; 赵建军; 毕新宇; 邵永孚

    2003-01-01

    Objective To discuss the prognosis of primary liver carcinoma treated with local resection and factors affecting prognosis.Methods The data of 130 patients who had been treated from October 1989 to October 1995 were analyzed retrospectively. We analyzed the concrete operating methods, the cause of postoperative complications and factors affecting prognosis.Results Curative local resection was performed in 130 patients. Operation-related mort ality was 0.8% and the incidence of complication was 16.1% (n=18). The overal l 1-, 3- and 5-year survival rates were 82.1%, 60.6% and 48.2%, respective ly. Involvement of blood vessels or liver capsules and the elevation of AST bef ore operation were the significant factors affecting prognosis (P<0.05).Conclusion Local resection is a safe method characterized by little damage, rapid, less blo od loss, low complication rate and good prognosis.

  16. Risk factors of prognosis for patients with HBV related liver failure and the prognosis model%乙型肝炎相关肝功能衰竭患者预后危险因素及预后模型建立

    Institute of Scientific and Technical Information of China (English)

    汤伟亮; 谢青; 赵钢德; 董志霞; 项晓刚; 王晖; 周惠娟; 桂红莲; 郭斯敏; 庄焱

    2011-01-01

    目的 探讨影响乙型肝炎相关肝衰竭患者预后的危险因素并建立其预后模型.方法 回顾性收集2006年6月至2008年12月在我科收治的178例乙型肝炎相关肝衰竭患者的临床资料.采用x 2和t检验和非参数检验进行单因素分析,Logistic回归进行多因素分析.结果 年龄、腹水、感染、消化道出血、肝性脑病、肝肾综合征、甲胎蛋白、PT、WBC、TBil、DBil、Cr、BUN、血清钠在生存组与死亡组之间差异均有统计学意义(P<0.05).Logistic多因素分析进一步显示,肝性脑病、感染、PT、TBil是影响乙型肝炎相关肝衰竭患者预后的独立危险因素.同时对所得出的独立危险因素建立该人群的预后判断模型,通过计算预后指数并绘制ROC曲线,计算其曲线下面积(AUC)为0.931(95%CI:0.893~0.970).其评估价值优于CTP分级(0.862)、MELD评分(0.807)及MELD-Na评分(0.774).结论 肝性脑病、感染、PT、TBil是影响乙型肝炎相关肝衰竭患者预后的独立危险因素.建立的预后模型能够较为准确地预测乙型肝炎相关肝衰竭患者的短期预后,是一个较为理想的乙型肝炎相关肝衰竭预后评估系统.%Objective To investigate the risk factors of the prognosis for HBV related liver failure and thus to establish a prognosis model. Methods Retrospective analysis of the clinical data of 178 patients with HBV related liver failure in Ruijin hospital from June 2006 to December 2008. Quantitative data were analyzed by using t test and rank test, and qualitative data were analyzed by using Chi-square test. Then Logistic regression analysis was used for selecting the independent risk factors of the prognosis for HBV related liver failure. Based on independent risk factors from Logistic regression analysis, prognostic model for the patients with HBV related liver failure was established. Results The differences of age, ascites, infection, upper gastrointestinal bleeding, hepatic

  17. Clinical characteristics and risk factors of prognosis in children with brain trauma in PICU%PICU儿童颅脑外伤的临床特点及预后相关危险因素分析

    Institute of Scientific and Technical Information of China (English)

    郭张妍; 裴亮; 刘春峰

    2015-01-01

    目的 探讨儿童颅脑外伤的临床特点及预后相关的危险因素.方法 对2009年1月至2014年12月中国医科大学附属盛京医院PICU收治的符合颅脑外伤患儿的临床资料进行回顾性分析,采用单因素和多因素Logistic回归分析方法,分析入院时Glasgow昏迷评分(GCS)评分,入院24h内的血糖、血乳酸、PT、INR、血钠、血钾、脉搏以及入院时间、年龄、性别、是否手术治疗,发生呼吸衰竭、休克及脑疝等因素与患儿生存预后的关系.结果 125例患儿中,存活84例,死亡41例,病死率为32.8%.相关危险因素单因素分析结果显示,入院时GCS评分、血糖、血乳酸、INR、呼吸衰竭、休克对儿童颅脑外伤预后有显著影响(P<0.05).多因素Logistic回归分析显示GCS评分、血糖、血乳酸、呼吸衰竭是影响儿童颅脑外伤预后的独立危险因素(OR分别为7.434、0.473、0.615、0.000,P<0.05).结论 儿童颅脑外伤具有病情凶险、预后差、致残致死率高的临床特点,入院时GCS评分,入院24h内的血糖、血乳酸水平及发生呼吸衰竭是影响儿童颅脑外伤预后的独立危险因素.%Objective To analyze the clinical characteristics and risk factors of prognosis in children with brain trauma.Methods We retrospectively analyzed the clinical data of 125 cases diagnosed as brain trauma in PICU of Shengjing Hospital affiliated to China Medical University from January 2009 to December 2014.The risk factors influencing prognosis were analyzed by using single factor analysis and multiple factors Logistic regression methods.The risk factors included Glasgow coma score (GCS) on admission,blood glucose,lactic acid,prothrombin time,international normalized ratio (INR),serum sodium,serum potassiumin,pulse within 24 hours after admission,gender,age,time for therapy,shock,respiratory failure,cerebral hermia and surgery.Results Eighty-four cases survived and 41 cases died.The fatality rate was 32.8

  18. 颈椎创伤合并脊髓损伤手术治疗的预后和影响因素%Prognosis and influencing factors of cervical spinal cord injury patients with trauma operation

    Institute of Scientific and Technical Information of China (English)

    何小勇

    2015-01-01

    Objective Observation and analysis of influencing factors of spinal cord injury, provides references for the clinical treatment. Methods 237 patients of in our hospital in last 10 years of with cervical trauma complicated with spinal cord injury were collected, multiple factor correlation analysis was used to analyze the prognosis through the age, sex, cause of injury, the time of referral, operation start time, the injury site (section), complications, spinal canal encroachment rate, hormone applicationuse of hormones within the 8h, prehospital cervical support, preoperative traction, and the operation mode of this injury prognosis. Results By single factor analysis of 12 factors influenced, the referral time, preoperative history of injury, operation start time, spinal canal encroachment rate and hormone application within 8h, pre hospital neck support, whether preoperative traction (P≤0.1), the other factors had poor correlation with the prognosis of the patients:age (P=0.203), gender (P=0.982), the damage stage (P=0.774), operation mode(P=0. 189). The influencing factors on screening of multiple factor Logistic regression analysis found that referral time, operation start time, spinal canal encroachment rate and hormone use application within 8h were cClosely related to the prognosis (P<0.05). Conclusion The main factors that influence the prognosis of patients with cervical spine trauma complicated with spinal cord injury were: the referral time, operation start time, spinal canal encroachment rate and hormone application within 8h. Fast and effective pre-hospital aid, the appropriate operation time, timely decompression of the spinal cord and the early application of hormone could effectively improve the prognosis of cervical vertebra trauma complicated with spinal cord injury.%目的 观察分析颈椎创伤合并脊髓损伤手术治疗的预后和影响因素,为临床治疗该类疾病提供参考. 方法 收集本院10年来颈椎创

  19. Adverse effects of fullerenes on endothelial cells: Fullerenol C60(OH24 induced tissue factor and ICAM-1 membrane expression and apoptosis in vitro

    Directory of Open Access Journals (Sweden)

    Monique P Gelderman

    2008-03-01

    Full Text Available Monique P Gelderman1, Olga Simakova2, Jeffrey D Clogston3, Anil K Patri3, Sheena F Siddiqui1, Alexander C Vostal1, Jan Simak11CBER, FDA, Rockville, MD, USA; 2School of Medicine, USUHS, Bethesda, MD, USA; 3Nanotechnology Characterization Lab, Advanced Technology Program, SAIC-Frederick, Frederick, Maryland, USAAbstract: We studied the effects of a C60 water suspension at 4 µg/mL (nC60 and the water soluble fullerenol C60(OH24 at final concentrations of 1—100 µg/mL on human umbilical vein endothelial cells (HUVECs in culture. We found that a 24 hr treatment of HUVECs with C60(OH24 at 100 µg/mL significantly increased cell surface expression of ICAM-1(CD54 (67 ± 4% CD54+ cells vs. 19 ± 2 % CD54+ cells in control; p < 0.001. In addition, this treatment induced the expression of tissue factor (CD142 on HUVECs (54 ± 20% CD142+ cells vs 4 ± 2% CD142+ cells in control; p = 0.008 and increased exposure of phosphatidylserine (PS (29 ± 2% PS+ cells vs. 12 ± 5% PS+ cells in control; p < 0.001. Analysis of cell cycle and DNA fragmentation (TUNEL showed that both nC60 and C60(OH24 caused G1 arrest of HUVECs and C60(OH24 induced significant apoptosis (21 ± 2% TUNEL+ cells at 100 µg/mL of C60(OH24 vs. 4 ± 2% TUNEL+ cells in control; p < 0.001. We also demonstrated that both nC60 and C60(OH24 induced a rapid concentration dependent elevation of intracellular calcium [Ca2+]i. This could be inhibited by EGTA, suggesting that the source of [Ca2+]i in fullerene stimulated calcium flux is predominantly from the extracellular environment. In conclusion, fullerenol C60OH24 had both pro-inflammatory and pro-apoptotic effects on HUVECs, indicating possible adverse effects of fullerenes on the endothelium.Keywords: endothelial cells, fullerenes, tissue factor, apoptosis, ICAM-1, flow cytometry

  20. Reacções cutâneas adversas aos inibidores do receptor do factor de crescimento epidérmico: estudo de 14 doentes Adverse cutaneous reactions to epidermal growth factor receptor inhibitors: a study of 14 patients

    Directory of Open Access Journals (Sweden)

    Felicidade Santiago

    2011-06-01

    Full Text Available FUNDAMENTOS: O cetuximab e o erlotinib, inibidores do receptor do factor de crescimento epidérmico, provocam frequentemente reacções cutâneas adversas peculiares. OBJETIVOS: Caracterizar do ponto de vista clínico-evolutivo as reacções cutâneas adversas e avaliar a sua abordagem terapêutica. METODOLOGIA: Entre março/2005 e setembro/2009 foram seguidos 14 doentes com idade média de 59,6 anos, em tratamento com cetuximab (7 ou erlotinib (7, por neoplasia pulmonar (10 ou colorrectal (4. Retrospectivamente foi avaliado o padrão clínico evolutivo de reacção cutânea, o intervalo entre a introdução do fármaco e o início dos sintomas e a resposta ao tratamento. RESULTADOS: Doze doentes apresentaram erupção papulopustulosa predominantemente na face, decote e dorso, em média 13,5 dias após o início do fármaco. Efectuaram tratamento oral com minociclina ou doxiciclina e tópico com metronidazol, peróxido de benzoílo e/ou corticoide. Ocorreu melhoria das lesões em todos os doentes. Cinco doentes, em média oito semanas após o início da terapia, apresentaram granulomas piogénicos periungueais, em quatro casos associados a paroníquia, melhorados com tratamento tópico (antibióticos, corticoides e antissépticos. Observou-se xerose em alguns doentes e, de forma isolada, outros efeitos adversos, como telangiectasias e angiomas, alterações dos cabelos e cílios e nevos melanocíticos eruptivos. Na maioria dos doentes, a terapêutica com o inibidor do receptor do factor de crescimento epidérmico foi mantida. CONCLUSÃO: Com o crescente uso destas terapêuticas-alvo, torna-se obrigatório reconhecer e tratar os seus efeitos cutâneos adversos, assegurando uma intervenção atempada de forma a permitir a manutenção desta terapêuticaBACKGROUND: Cetuximab and erlotinib, epidermal growth factor receptor inhibitors, often cause peculiar adverse cutaneous reactions. OBJECTIVES: Our aim was to evaluate adverse cutaneous reactions

  1. Absence of transforming growth factor-beta type II receptor is associated with poorer prognosis in HER2-negative breast tumours

    DEFF Research Database (Denmark)

    Paiva, C E; Drigo, S A; Rosa, F E;

    2010-01-01

    BACKGROUND: The clinical relevance of transforming growth factor-beta (TGF-beta)-signalling pathway in breast carcinomas (BCs) remained elusive. This study aimed to evaluate the prognostic value of TGF-beta1 and transforming growth factor-beta type II receptor (TGF-betaRII) expression levels in.......489, P = 0.003]. TGF-betaRII positivity was an independent prognostic factor for DFS (HR = 0.439, P = 0.001) and overall survival (OS) (HR = 0.409, P = 0.003) in human epidermal growth factor receptor-2 (HER2)-negative patients. Absence of TGF-beta1 and TGF-betaRII proteins in breast tumour cells was...

  2. Ability to cope with adversity and influencing factors in associate degree nursing students%护理大专生应对逆境的能力及其影响因素分析

    Institute of Scientific and Technical Information of China (English)

    田茜; 范秀珍; 孟珠; 吕菲

    2011-01-01

    目的 了解在校护理大专生应对逆境的能力,并探讨其影响因素,为护理教育者提高学生逆境应对能力提供依据.方法 采用逆境商量表(ARP)、一般自我效能量表(GSES)及自行设计的一般资料问卷,对285名在校护理大专生进行调查,并分析其影响因素.结果:本组学生逆境商总分为(128.62±15.78)分;自我效能、是否曾担任班干部及是否为独生于女,对学生逆境商有显著影响(P<0.01,P<0.05),它们能解释42.4%的逆境商变异量,其中以自我效能的预测力最大,其解释量为39.1%,结论,在校护理大专生应对逆境的能力有待进一步提高,护理教育者可针对其主要影响因素采取有效的个体化策略,以提高其逆境应对能力.%Objective To investigate the associate degree nursing students' ability to cope with adversity and analyze its influencing factors,so as to provide evidence for nursing educators to take specific measures to improve the students' ability to cope with adversity. Methods A total of 285 associate degree nursing students were investigated with Adversity Response Profile(ARP),General Self-Efficacy Scale(GSES) and self-designed general information questionnaire. Results The total score of adversity quotient in associate degree nursing students was 128.62±15.78. The students' self-efficacy,whether they had been class leaders and whether they were only children had significant influence on their adversity quotient,which could explain 42.4 percent of variations of the adversity quotient. Self-efficacy was the best predictive variable which could explain 39.1 percent of variations of the adversity quotient Conclusion Associate degree nursing students' abilities to cope with adversity need to be improved. Nursing educators should take effective and personalized strategies to improve their ability to cope with adversity according to the influencing factors.

  3. Adverse Effects of Bisphosphonates

    DEFF Research Database (Denmark)

    Abrahamsen, Bo

    2010-01-01

    tolerated by the majority of patients, but serious adverse events have been recorded in some cases. Only the most common of adverse effects are robustly observable in clinical trials. In general, studies were not powered to detect effects that were lower in incidence than fractures. This review of adverse...

  4. Adverse effects of bisphosphonates

    DEFF Research Database (Denmark)

    Abrahamsen, Bo

    2010-01-01

    tolerated by the majority of patients, but serious adverse events have been recorded in some cases. Only the most common of adverse effects are robustly observable in clinical trials. In general, studies were not powered to detect effects that were lower in incidence than fractures. This review of adverse...

  5. 小儿心肺复苏的临床特点及预后的影响因素%Clinical characteristics and the influence factors of prognosis of pediatric cardiopulmonary resuscitation

    Institute of Scientific and Technical Information of China (English)

    王昕

    2015-01-01

    Objective:To analyze the clinical characteristics and the influence factors of prognosis of pediatric cardiopulmonary resuscitation.Methods:46 patients with pediatric cardiopulmonary resuscitation treatment were selected from May 2010 to May 2014.18 cases used cardiopulmonary resuscitation because of cardiac arrest;28 cases used cardiopulmonary resuscitation because of respiratory arrest.The clinical characteristics and prognosis of pediatric cardiopulmonary resuscitation were detailedly analyzed. Results:The cardiopulmonary resuscitation rate 42.9% of respiratory arrest children was higher than the cardiopulmonary resuscitation rate 16.7% of cardiac arrest children,and the difference was statistically significant(P<0.05).The children common diseases caused pediatric cardiopulmonary resuscitation were accidental injuries,infectious diseases and cardiovascular diseases and so on.Conclusion:More attention should be paid to the causes and clinical characteristics of pediatric cardiopulmonary resuscitation.Popularization of pediatric first-aid knowledge and doing a good job in the publicity and education work can effectively improve the rescue success rate of pediatric cardiopulmonary resuscitation and improve prognosis.%目的:分析小儿心肺复苏的临床特点及预后的影响因素。方法:2010年5月-2014年5月收治小儿心肺复苏治疗患者46例,其中因心跳停止采用心肺复苏18例,因呼吸停止采用心肺复苏28例,详细分析小儿心肺复苏的临床特点和预后。结果:呼吸停止患儿的心肺复苏率42.9%高于心跳停止患儿的心肺复苏率16.7%,差异具有统计学意义(P<0.05);引起小儿心肺复苏的患儿常见疾病有意外伤害、感染性疾病以及心血管疾病等。结论:应更加重视引起小儿心肺复苏的原因和临床特点,普及儿科急救的相关知识,做好宣传教育工作,有效提高小儿心肺复苏抢救成功率,改善预后。

  6. Characterization and prognosis factors of cerebro-vascular disease in Cienfuegos province. Caracterización y factores pronósticos de la enfermedad cerebrovascular en la Provincia de Cienfuegos.

    Directory of Open Access Journals (Sweden)

    Roberto Suárez Suri

    Full Text Available Fundaments: Cerebrovascular disease constitutes the third cause of death and the first cause of severe discapacity in adults in those countries that have a developed health system like ours. Objective: To characterise the patients with cerebrovascular disease and to determine the variables that influence upon their prognosis once it is established. Method: Prospective, descriptive, longitudinal study of a series of cases developed at the University Hospital ¨Dr. Gustavo Aldereguía Lima¨. Questionnaires were applied to the patients that fitted the inclusion criteria (n 1318 Results: The mean age was 66,08 years with a predominance of white patients ( 75,26 %, mainly males ( 56,67%. The risk factor of highest frequency was hypertension ( 43,24 % The evolution for alive patients without discapacities was 14,71%, alive with discapacities ( 57,96% and death 27,31%. There was a predominance of ischemic cerebrovascular disease (46,13 % of aterothrombotic infarcts and 14,94 % cardioembolic disease. In regards to hemorrhagic disease 13,42 % were intracerebral hemorrhage and 4,55% subarachnoid hemorrhage. There was a prognostic correlation between the clinical variables: consciousness, sight, sensibility, language, tone, Babinski , osteotendious reflexes and muscular force. For the general variables cerebral edema, bacterial bronchopneumonia , displacement of the medial line, diagnosis is some values, CT scan diagnoses in some values for diabetes mellitus and convulsions.

    Fundamento: Las enfermedades cerebrovasculares constituyen la tercera causa de muerte y la primera de discapacidad grave del adulto en los países con sistemas de salud desarrollados similares al nuestro. Objetivo : Caracterizar a los pacientes con enfermedades cerebrovasculares y determinar las variables que influyen en su pron

  7. Factors on prognosis in patients of stage pT3N0M0 thoracic esophageal squamous cell carcinoma after two-field esophagectomy

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    Yuxiang Wang

    2015-01-01

    Conclusion: For patients of pT3N0M0 thoracic ESCC, the independent factors were the site of a lesion for OS and PFS, Hb levels, small LN in CT, and number of removed LN for OS. The value of postoperative adjuvant therapy need be further proved.

  8. An evaluation of factors predicting breast recurrence and prognosis after recurrence, on distinguishing intramammary and extramammary recurrence, in breast-conserving surgery

    International Nuclear Information System (INIS)

    Recurrence of cancer in the breast is an important problem in breast-conserving therapy. We evaluated risk factors for recurrence from the viewpoint of recurrence type and outcome after recurrence. Of 533 cases of breast cancer treated with breast-conserving surgery from April 1989 through July 2000, disease in 66 recurred (12.4%) and were classified as 23 cases of breast recurrence only, 16 cases of both breast recurrence and distant metastasis, and 27 cases of distant metastasis only. The clinical factors examined included age, lymphatic invasion, nodal status, extensive intraductal component (EIC), proliferative activity, and estrogen receptor (ER) status. Of the 39 cases of breast recurrence, 19 had intramammary tumors and 20 had extramammary tumors of the skin, subcutaneous tissue, or muscle, including 8 cases with inflammatory breast recurrence. Multivariate analysis showed that factors correlated with breast recurrence were age, ER status, proliferative activity, and surgical margin. EIC-comedo was related to intramammary recurrence, whereas lymphatic invasion and nodal status were related to extramammary recurrence. Postoperative irradiation was an effective treatment for tumors in young women and tumors with positive margins or a comedo component. Outcome after breast recurrence depended on nodal status at primary operation, and survival rates were worst in patients with inflammatory breast recurrence. In conclusion, age, EIC-comedo status, the surgical margin, and negative ER status were correlated with breast recurrence. Countermeasures against these factors should be investigated. (author)

  9. Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro.

    LENUS (Irish Health Repository)

    Lanigan, Fiona

    2010-01-01

    The homeobox-containing transcription factor muscle segment homeobox 2 (Msx2) plays an important role in mammary gland development. However, the clinical implications of Msx2 expression in breast cancer are unclear. The aims of this study were to investigate the potential clinical value of Msx2 as a breast cancer biomarker and to clarify its functional role in vitro.

  10. Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin-1 and induction of poor prognosis factors

    Czech Academy of Sciences Publication Activity Database

    Valach, J.; Fík, Z.; Strnad, Hynek; Chovanec, M.; Plzák, J.; Čada, Z.; Szabo, Pavol; Šáchová, Jana; Hroudová, Miluše; Urbanová, Markéta; Steffl, M.; Pačes, Jan; Mazánek, J.; Vlček, Čestmír; Betka, J.; Kaltner, H.; André, S.; Gabius, H. J.; Kodet, R.; Smetana, K.; Gál, P.; Kolář, Michal

    2012-01-01

    Roč. 131, č. 11 (2012), s. 2499-2508. ISSN 0020-7136 R&D Projects: GA MŠk 2B06106 Institutional research plan: CEZ:AV0Z50520514 Keywords : carcinoma * stroma * actin * lectin Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 6.198, year: 2012

  11. Acute histologic chorioamnionitis is a risk factor for adverse neonatal outcome in late preterm birth after preterm premature rupture of membranes.

    Directory of Open Access Journals (Sweden)

    Seung Mi Lee

    Full Text Available BACKGROUND: The objective of this study was to determine whether acute histologic chorioamnionitis is associated with adverse neonatal outcomes in late preterm infants who were born after preterm PROM. METHODOLOGY/PRINCIPAL FINDINGS: The relationship between the presence of acute histologic chorioamnionitis and adverse neonatal outcome was examined in patients with preterm PROM who delivered singleton preterm newborns between 34 weeks and 36 6/7 weeks of gestation. Nonparametric statistics were used for data analysis. The frequency of acute histologic chorioamnionitis was 24% in patients with preterm PROM who delivered preterm newborns between 34 weeks and 36 6/7 weeks of gestation. Newborns born to mothers with histologic chorioamnionitis had significantly higher rates of adverse neonatal outcome (74% vs 51%; p<0.005 than those without histologic chorioamnionitis. This relationship remained significant after adjustment for gestational age at preterm PROM, gestational age at delivery, and exposure to antenatal corticosteroids. CONCLUSIONS/SIGNIFICANCE: The presence of acute histologic chorioamnionitis is associated with adverse neonatal outcome in late preterm infants born to mothers with preterm PROM.

  12. TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition

    OpenAIRE

    Yu Tian; Ming Lu; Weiming Yue; Lin Li; Shuhai Li; Cun Gao; Libo Si; Lei Qi; Wensi Hu; Hui Tian

    2014-01-01

    In this study, we found that increased BRF2 protein expression was prevalent in NSCLC. Overexpression of BRF2 correlated with abnormal expression of E-cadherin, N-cadherin, and snail. Additionally, expression of BRF2 was found to be an independent prognostic factor in NSCLC patients. Furthermore, we showed that targeted knockdown of BRF2 expression could inhibit the migratory and invasive abilities of NSCLC cells and induced loss of the epithelial-mesenchymal transition of NSCLC cells. These ...

  13. Confirmation and types division of regional prognosis factors of uranium resources based on GIS-taking Shuangqiao-Xinlu area as an example

    International Nuclear Information System (INIS)

    Based on the analysis of uranium metallogenic settings of Shuangqiao-Xinyu area,the prognostic factors are classified into 3 classes of necessary, important and secondary according to its 'contribution' to the metallization in known deposits. This made the driving data needed for the potential evaluation based on GIS clear in role levels and will improve the efficiency and quality for the evaluation. (authors)

  14. High risk factors of occurrence and prognosis of infantile persistent diarrhea disease%婴幼儿迁延性腹泻病发病及预后的高危因素

    Institute of Scientific and Technical Information of China (English)

    石永生; 王永军; 蒋成鹏; 周丽

    2011-01-01

    Objective: To explore the high risk effect factors of occurrence and prognosis of infantile persistent diarrhea disease. Methods: 76 infants according with diagnostic criteria who were in the hospital from January 2007 to December 2009 were selected,60 infants with acute diarrhea at the same period were selected as control group; conditional lngistic regression analysis was used to screen the high risk effect factors of occurrence of infantile persistent diarrhea disease. Results: The high risk effect factors of occurrence of infantile persistent diarrhea disease included malnutrition ( OR = 6. 073 ), anemia ( OR = 2. 505 ), infants less than one year ( OR = 2. 125 ), antibiotic consumption ( OR = 1. 091 ), non - breast feeding ( OR =0. 329); the high risk effect factors of prognosis of infantile persistent diarrhea disease included malnutrition ( 0R = 7. 286), abnormal humoral immunity ( OR = 6. 873), extraintestinal infection ( OR = O. 276), course of the disease ( OR = 0. 062 ) . Conclusion: For the infants less than one year, preventing and correcting malnutrition, using antibiotics reasonably, advocating breast feeding actively may reduce the incidence of infantile persistent diarrhea disease; for the infants with acute diarrhea, enhancing nursing, preventing secondary infection during the course of the disease, correcting abnormal humoral immunity may improve the prognosis obviously.%目的:探讨影响婴幼儿迁延性腹泻病发病及预后的高危因素.方法:选取2007年1月~2009年12月收住儿内科符合诊断标准的病例76例,以同期急性腹泻病患儿60例作对照,经条件Logistic回归分析筛选影响其发病的危险因素.结果:影响其发病的危险因素有5个,即营养不良(OR=6.073)、贫血(OR=2.505)、1岁以下婴儿(OR=2.125)、使用抗生素(OR=1.091)、非母乳喂养(OR=0.329).影响其预后的危险因素有4个,即营养不良(OR=7.286)、体液免疫异常(OR=6.873)、肠外感染(OR=0.276)、病程(OR=0

  15. 56例老年弥漫大B淋巴瘤预后相关因素的研究%Research on relevant factors of prognosis of 56 elderly patients with DL-BCL

    Institute of Scientific and Technical Information of China (English)

    杨朋; 李艳; 蔡存伟; 邹志英

    2014-01-01

    目的:探讨老年弥漫大B细胞淋巴瘤(DLBCL)的预后相关因素。方法回顾性分析2007年8月~2012年7月沈阳市第四人民医院收治的56例老年DLBCL患者的年龄、Ann-Arbor分期、B症状、体能状态ECOG评分、骨髓浸润、最大肿块直径、乳酸脱氢酶(LDH)、β2-微球蛋白(β2-MG)、国际预后评分指数(IPI)、细胞来源、Ki-67指数、治疗方案等临床资料,研究上述指标与预后的相关性。结果56例患者中位生存时间为25.2个月,2年总生存(OS)率为49.7%,总完全缓解(CR)率为50.0%;CHOP方案组CR 13例(40.6%),利妥昔单抗(Rituximab)联合CHOP(R-CHOP)方案组CR 15例(62.5%),R-CHOP组的总有效率及CR率均优于CHOP组(均P<0.05)。单因素分析显示:年龄≥80岁、Ann Arbor分期、骨髓受累、ECOG评分、最大肿块直径≥10 cm、IPI、治疗前LDH值、免疫分型、治疗方案均与预后有关(P<0.05或P<0.01);COX回归多因素分析表明,IPI、骨髓浸润、免疫分型、化疗方案是影响老年DLBCL患者预后的独立危险因素(P<0.05或P<0.01)。结论老年DLBCL具有肿瘤分期晚、合并疾病多、疗效差、生存期短等特点;IPI、骨髓浸润、免疫分型、化疗方案是老年DLBCL预后的独立危险因素;R-CHOP方案能提高疗效及改善预后。%Objective To study the prognostic factors of elderly patients with diffuse large B-cell lymphoma (DLBCL). Methods Clinical data of 56 cases of DLBCL patients admitted by the Fourth People's Hospital of Shenyang City from August 2007 to July 2012 were retrospectively analyzed, including the age, Ann-Arbor staging, B symptoms, ECOG score of performance status, bone marrow invasion, the maximum diameter of tumor, LDH,β2-MG, IPI, cell source, Ki-67 index, therapeutic regimen. The correlation between these indexes and prognosis was analyzed. Results For the 56 patients, the median survival time was 25.2 months, and the overall survival (OS) rate was 49.7% in

  16. 卵巢未成熟畸胎瘤的治疗与预后因素的分析%Analysis of factor influencing prognosis for immature teratoma of ovary

    Institute of Scientific and Technical Information of China (English)

    张彦娜; 李孟达; 刘富元; 张惠忠

    2001-01-01

    transformation compared to those with immature teratomas (P<0.05). The occurrence of benign change in recurent tumors led to the patient having long remissions (P<0.05). Conclusions:The immediate postoperative chemotherapy (within 7 days) is the important factor influencing the prognosis of immature teratomas. The immature teratomas that have neural elements in the tumors have a better prognosis. Mature teratomas have the characteristics of malignant transformation and the recurrent immature teratomas have the those of benign change. So immediate chemotherapy must be emphasized for immature teratomas and everything should be done to maintain life in these patients to wait for the onset of benign transformation.

  17. Are the prostate cancers with intermediary risk treated by conformal irradiation or by permanent implants worth to be divided in function of the prognosis factors number fro a better adapted treatment?; Les cancers de la prostate de risque intermediaire traites par irradiation conformationnelle ou par implants permanents meritent-ils d'etre subdivises en fonction du nombre de facteurs pronostiques pour un traitement plus adapte?

    Energy Technology Data Exchange (ETDEWEB)

    Salema, N. [Institut Paoli Calmettes, 13 - Marseille (France)

    2009-10-15

    Purpose: the treatment of prostate cancers of intermediary risk stands on either an association of a conformal radiotherapy with short hormonotherapy or the complete prostatectomy. In some cases the brachytherapy was proposed. The number of present prognosis factors is not generally a factor directing the therapy decision. We were interested in this population of patients by analysing their prognosis factors and the influence of their number on the survival. Conclusion: the number of prognosis factors seems to have a prognosis valuer in our population. If these data are confirmed by other series, it will be perhaps necessary to adapt the management of prostate cancers of intermediary risk in the future prospective studies. (N.C.)

  18. Expression of connective tissue growth factor in tumor tissues is an independent predictor of poor prognosis in patients with gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Lu-Ying Liu; Yan-Chun Han; Shu-Hua Wu; Zeng-Hua Lv

    2008-01-01

    AIM: To examine the expression of connective tissue growth factor (CTGF), also known as CCN2, in gastric carcinoma (GC), and the correlation between the expression of CTGF, dinicopathologic features and clinical outcomes of patients with GC.METHODS: One hundred and twenty-two GC patients were included in the present study. All patients were followed up for at least 5 years. Proteins of CTGF were detected using the Powervision two-step immunostaining method.RESULTS: Of the specimens from 122 GC patients analyzed for CTGF expression, 58 (58/122, 47.5%) had a high CTGF expression in cytoplasm of gastric carcinoma cells and 64 (64/122, 52.5%) had a low CTGF expression. Patients with a high CTGF expression showed a higher incidence of lymph node metastasis than those with a low CTGF expression {P = 0.032). Patients with a high CTGF expression had significantly lower 5-year survival rate than those with a low CTGF expression (27.6% vs 46.9%, P = 0.0178), especially those staging I + H + m (35.7% vs 65.2%, P = 0.0027).CONCLUSION: GC patients with an elevated CTGF expression have more lymph node metastases and a shorter survival time. CTGF seems to be an independent prognostic factor for the successful differentiation of high-risk GC patients staging I + n + m. Over-expression of CTGF in human GC cells results in an increased aggressive ability.

  19. The predictability for the prognosis of breast cancer using the apparent diffusion coefficient value of diffusion weighted 3T MRI and the standardized uptake value of positron emission tomography/CT: Assessment of prognostic factor

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Seong Joo; Kim, Keum Won; Jang, Hye Young; Hwang, Cheol Mog; Kim, Dae Ho; Sohn, Jang Sihn; Kim, Jin Suk; Lee, Jin Yong [Konyang Univ. College of Medicine, Daejeon (Korea, Republic of)

    2012-09-15

    To correlate the apparent diffusion coefficient (ADC) value and peak standardized uptake value (pSUV) with histologic grade and clinical prognostic factors of breast ductal carcinoma. Fifty breast cancers of 49 patients (age range: 37-83 years, mean: 53 years) were studied retrospectively. The breast cancers included 4 ductal carcinoma in situ (DCIS) and 46 invasive ductal carcinomas (IDC). The relationships for both pSUV and ADC values with clinicopathological prognostic factors (age, tumor size, histologic grade, nodal metastasis, hormone receptor and HER-2 neu status) were statistically evaluated. The histologic type of ductal carcinoma include DCIS (n = 4) and IDC (n = 46, grade 1 = 10, grade 2 = 13, and grade 3 = 23). pSUV was associated with histologic grade and tumor size and the ADC value was associated with histologic grade (p < 0.05). As the histologic grade becomes higher, the ADC values decrease, while pSUV and pSUV/ADC increase (p < 0.05). The characterization accuracy of pSUV/ADC (90.2%) was higher than pSUV (86.7%) and ADC values (25.4%) alone for the diagnosis of breast cancer (p < 0.05). pSUV and ADC values correlated with histologic grade, and tumor size. The pSUV/ADC value had a high accuracy for the diagnosis of breast cancer. Therefore, pSUV and ADC values provided additional information for predicting histologic grade and prognosis of breast cancer.

  20. The predictability for the prognosis of breast cancer using the apparent diffusion coefficient value of diffusion weighted 3T MRI and the standardized uptake value of positron emission tomography/CT: Assessment of prognostic factor

    International Nuclear Information System (INIS)

    To correlate the apparent diffusion coefficient (ADC) value and peak standardized uptake value (pSUV) with histologic grade and clinical prognostic factors of breast ductal carcinoma. Fifty breast cancers of 49 patients (age range: 37-83 years, mean: 53 years) were studied retrospectively. The breast cancers included 4 ductal carcinoma in situ (DCIS) and 46 invasive ductal carcinomas (IDC). The relationships for both pSUV and ADC values with clinicopathological prognostic factors (age, tumor size, histologic grade, nodal metastasis, hormone receptor and HER-2 neu status) were statistically evaluated. The histologic type of ductal carcinoma include DCIS (n = 4) and IDC (n = 46, grade 1 = 10, grade 2 = 13, and grade 3 = 23). pSUV was associated with histologic grade and tumor size and the ADC value was associated with histologic grade (p < 0.05). As the histologic grade becomes higher, the ADC values decrease, while pSUV and pSUV/ADC increase (p < 0.05). The characterization accuracy of pSUV/ADC (90.2%) was higher than pSUV (86.7%) and ADC values (25.4%) alone for the diagnosis of breast cancer (p < 0.05). pSUV and ADC values correlated with histologic grade, and tumor size. The pSUV/ADC value had a high accuracy for the diagnosis of breast cancer. Therefore, pSUV and ADC values provided additional information for predicting histologic grade and prognosis of breast cancer

  1. Understanding Cancer Prognosis

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    Full Text Available ... Cancer? Cancer Statistics Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview–for health ... Is Cancer Cancer Statistics Causes & Prevention Risk Factors Genetics Cancer Prevention Overview Screening Cancer Screening Overview Screening ...

  2. Understanding Cancer Prognosis

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    Full Text Available ... What Is Cancer? Cancer Statistics Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview– ... Resources What Is Cancer Cancer Statistics Causes & Prevention Risk Factors Genetics Cancer Prevention Overview Screening Cancer Screening ...

  3. Understanding Cancer Prognosis

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    Full Text Available ... Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview ... Statistics Understanding Cancer What Is Cancer Cancer Statistics Causes & Prevention Risk Factors Genetics Cancer Prevention Overview Screening ...

  4. Understanding Cancer Prognosis

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    Full Text Available ... Contact Dictionary Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview–for ... Cancer What Is Cancer Cancer Statistics Causes & Prevention Risk Factors Genetics Cancer Prevention Overview Screening Cancer Screening Overview ...

  5. Understanding Cancer Prognosis

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    Full Text Available ... Contact Dictionary Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview– ... Is Cancer Cancer Statistics Cancer Disparities Causes & Prevention Risk Factors Genetics Cancer Prevention Overview Screening Cancer Screening ...

  6. Understanding Cancer Prognosis

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    Full Text Available ... Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview–for health ... Is Cancer Cancer Statistics Causes & Prevention Risk Factors Genetics Cancer Prevention Overview Screening Cancer Screening Overview Screening ...

  7. Understanding Cancer Prognosis

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    Full Text Available ... Search About Cancer What Is Cancer? Cancer Statistics Causes and Prevention Risk Factors Genetics Cancer Prevention Overview ... Using Trusted Resources What Is Cancer Cancer Statistics Causes & Prevention Risk Factors Genetics Cancer Prevention Overview Screening ...

  8. Epidemiology Characteristics and Prognosis Risk Factors Analysis Research on Acute Pesticide Intoxication in One District%急性农药中毒流行特征及预后影响因素研究

    Institute of Scientific and Technical Information of China (English)

    杜育刚; 李清雅; 陈建南

    2012-01-01

    OBJECTIVE To analyze the epidemiology characteristics of acute pesticide intoxication, then make clear the risk factors of acute pesticide intoxication prognosis, and explore its regularity of the poisoning and the feasibility of controlling measures. METHODS 306 cases of acute pesticide intoxication were collected from January 2007 to December 2011 with self-design questionnaire, and each data of them were collected. RESULTS In 306 cases, 173 cases (56.5%) were poisoned by orgnaophosphorus, 49 cases (16.0%) by pyrethroid and 81 cases (26.5%) by parquet. The risk factors affecting the prognosis of acute pesticide intoxication included sex (OR = 3.930), poisoning extent (OR = 10.166) , poisonous types (OR = 5.854) , oxygen inhale (OR =0.211), respiratory system abnormality (OR =6.180), fever (OR = 7.182), pulse (OR =4.063), renal functions (OR = 4.670) and electrocardiography (OR - 2.272). CONCLUSION We have made clear the epidemiology characteristics, and analyzed the risk factors of prognosis. We raise prevention and remedy strategies of acute pesticide intoxication.%目的 分析急性农药中毒病例的流行特征,摸清影响预后的危险因素,探讨其发病规律及可行的防治策略.方法 通过回顾性收集2007年1月~2011年12月期间的306例急性农药中毒病例;采用自行设计的调查表,收集各个病例的各种资料.结果 306例患者中,有机磷中毒173例(56.5%)、拟除虫菊酯中毒49例(16.0%)、百草枯中毒81例(26.5%)、其他中毒3例(1.0%);影响预后的因素包括性别(OR=3.930)、中毒程度(OR=10.166)、毒物种类(OR=5.854)、氧气吸入(OR=0.211)、呼吸系统异常(OR=6.180)、发热(OR=7.182)、脉搏(OR=4.063)、肾功能(OR=4.670)、心电图检查(OR=2.272)等指标.结论 摸清了急性农药中毒的流行特征,分析了影响预后的危险因素,并提出了急性农药中毒的预防和救治策略.

  9. Treatment of Serious Hypertensive Intracerebral Hemorrhage with CT-location Drill-crandum Smashing-draw and Analysis of Prognosis Factors

    Institute of Scientific and Technical Information of China (English)

    Huang Panbing

    2000-01-01

    Objective: To study curative effect of CT-location drill-cranium smashing-draw and affective pregniosis factors for serious hypertensive intracerebral hemorrhage (HIH). Methods :15 cases of serious HIH(group A)were treated with CT-location drill-cranium smashing-draw ,other 15 patients treated (group B)were treated with medicine only as controls. Results: The curative rate (20%) anis improvable rate (33.3%)in group A were higher than that of (6.7% and 26.7%)in group B (P<0. 001). The mortality rate (46.7%)in group A was lower than that of (66.6%)in group B significantly (P<0.001). Conclusions: The efffect of the therapy was satisfactory The higher or lower of the mortality rate was closely related to operative time 、 m-hemorrhage 、 location and range of the hemotoma

  10. Tumor-derived hepatocyte growth factor is associated with poor prognosis of patients with glioma and influences the chemosensitivity of glioma cell line to cisplatin in vitro

    Directory of Open Access Journals (Sweden)

    Guo You-feng

    2012-06-01

    Full Text Available Abstract Background We examined the association of tumor-derived hepatocyte growth factor (HGF with the clinicopathological features of gliomas and investigated the effect of HGF inhibition on the biological behavior of tumor cells in vitro in order to determine whether HGF is a valuable prognostic predictor for glioma patients. Methods Seventy-six cases of glioma were collected. The tumor-derived HGF expression, cell proliferation index (PI and intratumoral microvessels were evaluated by immunohistochemistry. Correlation between immunostaining and clinicopathological parameters, as well as the follow-up data of patients, was analyzed statistically. U87MG glioma cells were transfected with short interference (si-RNA for HGF, and the cell viability, migratory ability and chemosensitivity to cisplatin were evaluated in vitro. Results Both high HGF expression in tumor cells (59.2%, 45/76 and high PI were significantly associated with high-grade glioma and increased microvessels in tumors (P P = 0.004 and high-expression of HGF (P = 0.008 emerged as independent prognostic factors for the overall survival of glioma patients. The tumor-derived HGF mRNA and protein expressions were significantly decreased in vitro after transfection of HGF siRNA. HGF siRNA inhibited the cell growth and reduced cell migratory ability. Moreover, HGF siRNA transfection enhanced the chemosensitivity of U87MG glioma cells to cisplatin. Conclusion This study indicated that there was significant correlation among tumor cell-derived HGF, cell proliferation and microvessel proliferation in gliomas. HGF might influence tumor progression by modulating the cell growth, migration and chemoresistance to drugs. Increased expression of HGF may be a valuable predictor for prognostic evaluation of glioma patients.

  11. Analysis on the influential factors for prognosis of 81 patients with infective endocarditis%感染性心内膜炎81例预后影响因素分析

    Institute of Scientific and Technical Information of China (English)

    虞燕波; 邢云利; 梁金锐

    2016-01-01

    Objective To analyze the influential factors for prognosi of patients with infective endocarditis. Methods The clinical data of 81 patients with infective endocarditis in Beijing Friendship Hospital during January 1992 to October 2013 were retrospectively reviewed and ana-lyzed. Results Among these 81 patients with infective endocarditis,the male gender was predominated with a sex ratio of 2. 1:1,48 patients (59. 3% )had basic heart diseases,70 patients(87. 4% )had fever and 60. 5% patients had anemia. The bacterial cultures were positive in 38. 3% of patients,and 22. 2% patients accepted surgical treatment. Conclusion The data in this study showed that the clinical manifestations of infective endocarditis are complex with high mortality rate. Rheumatic heart disease is the basic disease for this infection and renal impairment is the risk factor for the poor prognosis of these patients.%目的:分析感染性心内膜炎(IE)的预后影响因素。方法调查1992年1月至2013年10月北京友谊医院确诊的81例 IE 患者病例资料,对其临床特点进行回顾性分析,并对可能的相关因素进行单因素统计学分析。结果81例患者中单因素分析显示,风湿性心脏病对于感染性心内膜炎患者的 OR =5.387(95% CI 1.626-8.425),肾脏损伤对于感染性心内膜炎患者的 OR =4.233(95% CI 1.607~10.494),外科治疗对于感染性心内膜炎患者的 OR =1.153(95% CI 1.121~1.440),具有统计学意义。结论 IE 临床表现复杂,是一种危害大、病死率较高的心脏疾病;风湿性心脏基础疾病以及肾脏损伤是患者预后不良的危险因素。

  12. Investigation of the status and influencing factors of adversity quotient of undergraduate nursing students%本科护生逆境商现状及其影响因素的调查分析

    Institute of Scientific and Technical Information of China (English)

    戴玉琴; 段功香; 申海艳; 陈银娟

    2012-01-01

    目的 了解本科护生逆境商的现状并探讨其影响因素.方法 采用逆境商量表及学习满意度量表对312名本科护生进行问卷调查.结果 护生逆境商和学习满意度总分分别为(127.54±15.01)分和(46.41±5.94)分,处于中等水平,且本科护生的逆境商与学习满意度呈正相关(P<0.01);教师素质与教学方法、教学过程、是否独生子女及是否担任班干部是影响本科护生逆境商的主要因素(P<0.01或P<0.05).结论 本科护生的逆境商水平有待提高,护理教育者可针对其主要影响因素采取有效的个性化措施,以提高本科护生应对逆境的能力.%Objective To investigate the status and influencing factors of adversity quotient of undergraduate nursing students. Methods A total of 312 nursing students were investigated with Adversity Response Profile and Learning Satisfaction Questionnaire. Results The total score of students' adversity quotient and Learning Satisfaction were( 127. 54 ± 15. 01 ) and (46.41 ±5. 94) respectively,and in a middle level. There was a positive statistically correlation between adversity quotient and learning satisfaction ( P < 0.01) . The influencing factors of adversity quotient were teachers'quality, teaching methods, teaching courses, from one -child family or not, class leaders or not (P <0.01 or P < 0.05). Conclusion The adversity quotient of undergraduate nursing students level need to be improved. Nursing educators should take targeted interventions and personalized measure to improve their ability to cope with adversity.

  13. From Hopeless to Good Prognosis: Journey of a Failing Tooth

    OpenAIRE

    Gupta, Saurabh; Deshmukh, Jeevanand; Khatri, Richa; Kulkarni, Vinaya Kumar; B Karthik

    2015-01-01

    Chronic periodontitis, along with associated clinical findings such as pathologic tooth migration, diastema, functional and aesthetic aberrations, poses an immense challenge to a dental professional. These findings convert clinical decision making into a daunting task and adversely affect the prognosis and the treatment plan for the presenting clinical problem. An interdisciplinary approach aimed at restoring functional and aesthetic needs of the affected individual within the limitations of ...

  14. Survey on Risk Factors for Adverse Pregnancy Outcomes in Patients with Gestational Diabetes Mellitus%妊娠糖尿病患者相关不良妊娠结局危险因素调查

    Institute of Scientific and Technical Information of China (English)

    王霞

    2015-01-01

    Objective To diagnoses the risk factors for adverse pregnancy outcomes in patients with gestational diabetes melitus.Methods 200 patients with gestational diabetes melitus in our hospital from May 2014 to May 2015 were selected , 100 cases were adverse pregnancy among them and another 100 cases were normal labor. Adverse pregnancy outcome risk factors were analysised. Results Adverse pregnancy risk factors including pregnant women over 35 years of age, low education, medication, unexpected pregnancy, etc. after analysis and discovery, among the factors, the greatest risk factor was the history of accidental pregnancy and the history of polution of the environment. Conclusion Influence factors of adverse pregnancy outcome of patients with gestational diabetes melitus were more, it should pay attention to the history of accidents and polution of the environment and the history of the contact population particularly,in order to ensure delivery safety.%目的 对妊娠糖尿病患者相关不良妊娠结局的危险因素进行调查分析.方法 选取我院在2014年5月~2015年5月接收的200例妊娠糖尿病患者,其中100例不良妊娠,另外100例正常分娩.对不良妊娠结局危险因素分析.结果 经过分析发现,不良妊娠危险因素包括:孕妇35岁以上、学历低、用药、意外妊娠等等,其中在多因素分析中,意外妊娠史和污染环境接触史为最大危险因素.结论 妊娠糖尿病患者不良妊娠结局影响因素比较多,尤其要注重意外妊娠史和有污染环境接触史的人群,确保分娩安全.

  15. Onset, prognosis and effect factors of postpartum depression%产后抑郁发生、转归及其影响因素

    Institute of Scientific and Technical Information of China (English)

    张小松; 赵更力; 陈丽君; 狄江丽

    2009-01-01

    目的:了解产后42天、6个月产后抑郁发生及42天产后抑郁在6个月时的恢复情况与其影响因素.方法:应用爱丁堡产后抑郁量表(EPDS)和产妇一般情况调查表在产后42天对551例无孕期并发症/合并症和精神疾患的产妇进行测评,并于产后6个月随访时再次测评,用SPSS 10.0统计软件对相关资料进行统计分析.结果:产后42天产后抑郁发病率为6.5%,6个月产后抑郁患病率为5.7%.42天产后抑郁患者有25.0%在6个月仍为产后抑郁,占6个月产后抑郁的25.9%;42天正常产妇有4.5%在6个月发生产后抑郁.家庭、工作及孩子因素是影响产后抑郁发生与恢复的重要因素.结论:产后较长时间内仍有可能发生产后抑郁,产后一定时期内产妇的精神状况仍应得到重视.%To explore the incidence of postpartum depression at 42 days and 6 months postpartum and the recovery process of postpartum depression, as well as effect factors. Methods: 551 healthy mothers without complications and mental diseases were investigated by EPDS and general status questionnaires respectively at 42 days and 6 months postpartum, the analysis was performed on SPSS 10. 0. Results: The incidences of postpartum depression at 42 days and 6 months were 6. 5% and 5.6%. About 25.0% women with post-partum depression at 42 days were still depressed at 6 months postpartum. Approximately 25. 9% women with postpartum depression at 6 months were depressed at 42 days. About 4. 5% healthy women at 42 days suffered postpartum depression at 6 months. The important effect factors of incidence and recovery of postpartum depression were family, employment and children. Conclusion: Postpartum depression maybe occur during longtime postpartum. Mental health status of childbirth women should be enhanced after delivery.

  16. Prognosis and Risk Factors for Congenital Airway Anomalies in Children with Congenital Heart Disease: A Nationwide Population-Based Study in Taiwan.

    Directory of Open Access Journals (Sweden)

    Yu-Sheng Lee

    Full Text Available The mortality risk associated with congenital airway anomalies (CAA in children with congenital heart disease (CHD is unclear. This study aimed to investigate the factors associated with CAA, and the associated mortality risk, among children with CHD.This nationwide, population-based study evaluated 39,652 children with CHD aged 0-5 years between 2000 and 2011, using the Taiwan National Health Insurance Research Database (NHIRD. We performed descriptive, logistic regression, Kaplan-Meier, and Cox regression analyses of the data.Among the children with CHD, 1,591 (4.0% had concomitant CAA. Children with CHD had an increased likelihood of CAA if they were boys (odds ratio [OR], 1.48; 95% confidence interval [CI], 1.33-1.64, infants (OR, 5.42; 95%CI, 4.06-7.24, or had a congenital musculoskeletal anomaly (OR, 3.19; 95%CI, 2.67-3.81, and were typically identified 0-3 years after CHD diagnosis (OR, 1.33; 95%CI 1.17-1.51. The mortality risk was increased in children with CHD and CAA (crude hazard ratio [HR], 2.05; 95%CI, 1.77-2.37, even after adjusting for confounders (adjusted HR, 1.76; 95%CI, 1.51-2.04. Mortality risk also changed by age and sex (adjusted HR and 95%CI are quoted: neonates, infants, and toddlers and preschool children, 1.67 (1.40-2.00, 1.93 (1.47-2.55, and 4.77 (1.39-16.44, respectively; and boys and girls, 1.62 (1.32-1.98 and 2.01 (1.61-2.50, respectively.The mortality risk is significantly increased among children with CHD and comorbid CAA. Clinicians should actively seek CAA during the follow-up of children with CHD.

  17. Hospital deaths and adverse events in Brazil

    Directory of Open Access Journals (Sweden)

    Pavão Ana Luiza B

    2011-09-01

    Full Text Available Abstract Background Adverse events are considered a major international problem related to the performance of health systems. Evaluating the occurrence of adverse events involves, as any other outcome measure, determining the extent to which the observed differences can be attributed to the patient's risk factors or to variations in the treatment process, and this in turn highlights the importance of measuring differences in the severity of the cases. The current study aims to evaluate the association between deaths and adverse events, adjusted according to patient risk factors. Methods The study is based on a random sample of 1103 patient charts from hospitalizations in the year 2003 in 3 teaching hospitals in the state of Rio de Janeiro, Brazil. The methodology involved a retrospective review of patient charts in two stages - screening phase and evaluation phase. Logistic regression was used to evaluate the relationship between hospital deaths and adverse events. Results The overall mortality rate was 8.5%, while the rate related to the occurrence of an adverse event was 2.9% (32/1103 and that related to preventable adverse events was 2.3% (25/1103. Among the 94 deaths analyzed, 34% were related to cases involving adverse events, and 26.6% of deaths occurred in cases whose adverse events were considered preventable. The models tested showed good discriminatory capacity. The unadjusted odds ratio (OR 11.43 and the odds ratio adjusted for patient risk factors (OR 8.23 between death and preventable adverse event were high. Conclusions Despite discussions in the literature regarding the limitations of evaluating preventable adverse events based on peer review, the results presented here emphasize that adverse events are not only prevalent, but are associated with serious harm and even death. These results also highlight the importance of risk adjustment and multivariate models in the study of adverse events.

  18. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview–for ...

  19. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Cancer What Is Cancer? Cancer Statistics Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview–for health professionals Research ...

  20. Occurrence of Septic Encephalopathy and Its Risk Factors Influencing Prognosis%脓毒性脑病发生及影响预后的危险因素分析

    Institute of Scientific and Technical Information of China (English)

    王露; 柴艳芬

    2011-01-01

    Objective To investigate the risk factors of septic encephalopathy ( SE ) and its influencing factors of prognosis. Methods Clinical data of 109 SE patients were collected to perform single and multivariate factor Logistic regression analysis. The risk factors influencing SE occurrence were calculated. Results SE incidence was 51. 38%. Elderly patients with a long smoking history, diabetes, coronary heart disease, coagulation disorders, electrolyte imbalance, APACHE Ⅱ ≥ 20 were prone to SE. Logistic regression analysis showed that diabetes, coagulation disorder and APACHE Ⅱ ≥20 were independent risk factors of SE occurrence. Coagulation disorder and APACHE Ⅱ ≥20 were independent risk factors of SE death. Conclusion SE has a high incidence. Patients with diabetes, coagulation disorder and APACHE Ⅱ ≥20 should be observed closely, and the mortality of patients with coagulation and APACHE Ⅱ ≥20 was high, which is of significance in clinical assessment of SE prognosis.%目的 探讨脓毒症患者并发脓毒性脑病的危险因素及影响预后的因素.方法 收集109例脓毒症患者的临床资料,采用单因素分析和多因素Logistic回归分析,统计影响脓毒性脑病发生和死亡的危险因素.结果 脓毒性脑病发病率为51.38%;高龄、长期吸烟史、糖尿病、冠心病、凝血功能障碍、电解质紊乱、入院时急性生理学与慢性健康状况Ⅱ(APACHEⅡ)评分≥20分的脓毒症患者易并发脓毒性脑病;Logistic回归分析结果显示脓毒症患者合并有糖尿病、凝血功能障碍及入院时APACHEⅡ评分≥20分是脓毒性脑病发生的独立危险因素.凝血功能障碍和APACHEⅡ评分≥20分是脓毒性脑病患者死亡的独立危险因素.结论 脓毒性脑病的发病率高,对有糖尿病、凝血功能障碍和APACHEⅡ评分≥20分脓毒症患者应密切观察,凝血功能障碍和APACHEⅡ评分≥20分的脓毒性脑病患者病死率高,对临床上评估脓

  1. Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer

    International Nuclear Information System (INIS)

    Stromal cell-derived factor (SDF)-1 (CXC chemokine ligand-12) is a member of the CXC subfamily of chemokines, which, through its cognate receptor (CXC chemokine receptor [CXCR]4), plays an important role in chemotaxis of cancer cells and in tumour metastasis. We conducted the present study to evaluate the effect of SDF-1 on the invasiveness and migration of breast cancer cells, and we analyzed the expression of SDF-1 and its relation to clinicopathological features and clinical outcomes in human breast cancer. Expression of SDF-1 mRNA in breast cancer, endothelial (HECV) and fibroblast (MRC5) cell lines and in human breast tissues were studied using RT-PCR. MDA-MB-231 cells were transfected with a SDF-1 expression vector, and their invasiveness and migration was tested in vitro. In addition, the expression of SDF-1 was investigated using immunohistochemistry and quantitative RT-PCR in samples of normal human mammary tissue (n = 32) and mammary tumour (n = 120). SDF-1 expression was identified in MRC5, MDA-MB-435s and MDA-MB-436 cell lines, but CXCR4 expression was detected in all cell lines and breast tissues. An autocrine loop was created following transfection of MDA-MB-231 (which was CXCR4 positive and SDF-1 negative) with a mammalian expression cassette encoding SDF-1 (MDA-MB-231SDF1+/+) or with control plasmid pcDNA4/GFP (MDA-MB-231+/-). MDA-MB-231SDF1+/+ cells exhibited significantly greater invasion and migration potential (in transfected cells versus in wild type and empty MDA-MB-231+/-; P < 0.01). In mammary tissues SDF-1 staining was primarily seen in stromal cells and weakly in mammary epithelial cells. Significantly higher levels of SDF-1 were seen in node-positive than in node-negative tumours (P = 0.05), in tumours that metastasized (P = 0.05), and tumours from patients who died (P = 0.03) than in tumours from patients who were disease free. It was most notable that levels of SDF-1 correlated significantly with overall survival (P = 0.001) and

  2. Prognosis of Cyclic Vomiting Syndrome

    Directory of Open Access Journals (Sweden)

    J. Gordon Millichap

    2016-03-01

    Full Text Available Investigators from Teikyo University School of Medicine, Tokyo, Japan, evaluated the clinical features, prognosis, and prophylaxis of cyclic vomiting syndrome and the relationship between the syndrome and levels of adrenocorticotropic/antidiuretic hormones (ACTH/ADH.

  3. The Prognosis of Child Abuse

    Science.gov (United States)

    Lynch, Margaret A.

    1978-01-01

    Reviews the prognosis for abused children in terms of death, re-injury, permanent physical damage, growth failure, intellectual retardation, and personality and behavior problems. Discusses problems of collecting data and inadequacies of intervention treatments. (JB)

  4. Study on the effect of different factors on the postoperative prognosis of patients with distal radius fracture%不同因素对桡骨远端骨折患者术后预后的影响研究

    Institute of Scientific and Technical Information of China (English)

    邓吉长

    2014-01-01

    Objective:To study the effect of different factors on the postoperative prognosis of patients with distal radius fracture. Methods:124 cases with distal radius fracture were selected from January 2009 to January 2013.73 cases were treated with locking compression plate fixation.2 cases were treated with kirschner wire and external fixation.48 cases were treated with T shaped steel plate.1 case was treated with kirschner wire.All cases were followed up for 6~48 months.The operation curative effect was evaluated by Cooney wrist score and imaging score mean.The different factors on the postoperative outcome were analyzed by univariate and multivariate Logistic regression analysis.Results:In the Cooney wrist score,100 cases were excellent;23 cases were good;1 case was ok;the excellent and good rate was 99.19%.In the imaging score,72 cases were excellent;44 cases were good;6 cases was ok;1 case was bad;the excellent and good rate was 93.55%.The Cooney wrist score was analyzed by univariate and Logistic analysis.and it considered that the fracture classification and fracture reduction were the significant effect factors(P<0.05).The Batra imaging score was analyzed by univariate and Logistic analysis,and it considered that age was an important factor(P<0.05).Conclusion:The fracture classification can affect the postoperative wrist function activities.The age is the influence factor of imaging score of postoperative prognosis.%目的:研究不同因素对桡骨远端骨折患者术后预后的影响。方法:2009年1月-2013年1月收治桡骨远端骨折患者124例,应用锁定加压钢板内固定术73例,克氏针加外固定架2例,T形钢板48例,克氏钉1例。所有患者随访6~48个月,应用Cooney腕关节评分及影像学评分手段评价手术疗效,并对影响术后预后的不同因素进行单因素和多因素 Logistic 分析。结果:Cooney 腕关节评分优100例,良23例,可1例,优良率99.19%;影像学评分中优72

  5. Research on related factors of post-stroke depression and their relationship with prognosis%脑卒中后抑郁相关因素与患者预后分析研究

    Institute of Scientific and Technical Information of China (English)

    张国利; 曾湘良; 刘芳; 朱勇

    2012-01-01

    目的 探讨脑卒中后抑郁的相关因素及患者预后分析.方法选择2008年2月~2011年2月本院住院治疗的280例脑卒中患者,采用抑郁自评量表、汉密尔顿抑郁量表对患者进行评估.280例患者中确诊为卒中后抑郁者62例,将32例接受早期干预治疗的卒中后抑郁者为观察组,30例未接受早期干预者为对照组.对可能引起脑中后抑郁的相关因素进行分析,并采用改良Barthel指数评估患者日常生活能力(ADL),采用FMA运动功能评定肢体运动功能.结果统计学分析显示文化程度、家庭关系、病变部位、偏瘫严重程度与患者脑卒中后抑郁显著相关(P 0.05);治疗后1、3及6个月进行评估,结果显示观察组MBI评分及FMA评分显著优于对照组(P 0.05); MBI scores and FMA scores in experience group were much better than that in control group on 1, 3 and 6 months of post-treatment (P < 0.05). Conclusion Culture degree, family relationship, lesion site, the hemiplegic degree are the risk factors for post-stroke depression. The patients who receive early treatment have better prognosis. Early treatment should be performed in order to promote the recovery and improve the prognosis of patients.

  6. Prognosis of ventricular fibrillation in hospital

    DEFF Research Database (Denmark)

    Jensen, G V; Torp-Pedersen, C; Køber, L

    1992-01-01

    (P = 0.01). Logistic regression analysis demonstrated that heart failure and cardiogenic shock were significant risk factors for in-hospital death among patients with IHD. Among discharged patients 1 and 5 years survival was 78% and 51% for patients with MI, 63% and 25% for patients with IHD, 67% and...... 54% for patients without IHD. A proportional hazard model demonstrated old age, heart failure and cardiogenic shock as risk factors for long-term prognosis, while MI was associated with a reduced relative risk ratio = 0.58 of long-term mortality among patients with IHD. In conclusion, patients with...

  7. 肝衰竭病原学分析及预后影响因素的Logistic回归分析%Liver failure:Etiology and Logistic regression analysis for the factors affecting its prognosis

    Institute of Scientific and Technical Information of China (English)

    汪佳月; 李家斌

    2016-01-01

    Objective:To understand the etiology for different liver failure and the factors affecting the prognosis .Methods:Retrospective Logistic regres-sion analysis was performed in 425 cases of liver failure pertaining to the etiology,gender,age,laboratory indexes and complications.Results:Univariate Lo-gistic regression analysis showed that the risks affecting the prognosis of different liver failure were involved in patient′s age,level of total bilirubin(TBIL) and direct bilirubin(DBIL),ratio of glutamic oxalacetic transaminase to glutamic-pyruvic transaminase(AST/ALT),content of albumin,blood ammonia and prealbumin,prothrombin(PT),prothrombin activity(PTA),count of white blood cell (WBC) and hemoglobin(HGB),level of creatinine,urea nitro-gen and serum sodium as well as concomitant hepatic encephalopathy,upper gastrointestinal hemorrhage,hepatorenal syndrome,spontaneous peritonitis and fluid and electrolyte imbalance.Conclusion:Man are susceptible to liver failure,particularly,it may progress as a result of chronic HBV infection.The prognosis of liver failure may be involved in various clinical indicators that can be used to estimate the patient′s conditions and outcomes.%目的:了解各型肝衰竭患者的病原学及影响肝衰竭患者预后的危险因素。方法:采用回顾性分析方法,对肝衰竭患者的病原学、性别、年龄、各项实验室指标及并发症情况等进行统计分析。结果:单因素Logistic回归分析结果显示,年龄、总胆红素( total bilirubin,TBIL)、直接胆红素( direct bilirubin,DBIL)、谷草转氨酶/谷丙转氨酶比值( the ratio of glutamic oxalacetic transaminase to glutamic-pyruvic transaminase,AST/ALT)、白蛋白、血氨、前白蛋白、凝血酶原时间( prothrombin time,PT)、凝血酶原活动度( prothrombin activityprothrombin time activity,PTA)、白细胞( white blood cell,WBC)计数、血红蛋白( hemoglobin,HGB)计数、肌

  8. A retrospective analysis of the factors influencing the prognosis of liver cirrhosis combined with spontaneous bacterial peritonitis%肝硬化合并自发性细菌性腹膜炎预后影响因素分析

    Institute of Scientific and Technical Information of China (English)

    李儒贵; 谭华炳; 占国清; 张薇薇; 胡波

    2011-01-01

    目的 探讨肝硬化合并自发性细菌性腹膜炎(SBP)预后的影响因素. 方法 回顾性分析135例肝硬化合并SBP患者的临床资料,根据其预后分为存活组(88例)与死亡组(47例),比较两组病例年龄、性别、既往SBP史、症状与体征、ChildPugh分值、外周血和腹水中白细胞数、并发症、重要生化指标等因素. 结果 两组病例在年龄、既往SBP史、腹部多数症状及其它(呃逆、黄疸加深、休克)、Child-Pugh评分、外周血中性粒细胞比例、腹水白细胞数及多核粒细胞(PMN)比例、多数并发症及发生并发症个数、重要生化指标间差异均有统计学意义(P<0.05,P<0.01). 结论 年龄、既往SBP史、多数症状与体征、Child-Pugh评分、外周血中性粒细胞比例、腹水白细胞数及多核粒细胞(PMN)比例、重要生化指标及并发症等因素均影响肝硬化并SBP患者转归,可作为评价此病预后的重要指标.%Objective To explore the factors influencing the prognosis of liver cirrhosis combined with spontaneous bacterial peritonitis(SBP). Methods Clinical data of 135 patients with cirrhosis combined with SBP were analyzed retrospectively. Cases were divided into alive group(n=88) and dead group(n=47) according to their prognosis. Age, sex, past history of SBP, symptoms and signs, Child-Pugh score, leucocyte in peripheral blood and ascites, complications and important biochemical indicators of the two groups were compared. Results There were significant statistical differences in age, past history of SBP, abdominal symptoms and others(hiccup, deepened jaundice and shock), Child-Pugh score, blood neutrophil proportion, leucocyte and polymorphonuclear(PMN) cells in ascites, complications, and important biochemical indicators(P<0.05, P<0.01) between the two groups. Conclusion Age, past history of SBP, most symptoms and signs, Child-Pugh score, blood neutrophil proportion, leucocyte and polymorphonuclear(PMN) cells in

  9. 本科护生应对逆境的能力及其影响因素分析%Ability to Cope with Adversity of Nursing Undergraduates and Its Influencing Factors

    Institute of Scientific and Technical Information of China (English)

    刘合乙

    2012-01-01

    目的 了解在校本科护生应对逆境的能力,探讨其影响因素,为护理教育者提高学生逆境应对能力提供依据.方法 采用逆境商量表及自行设计的一般资料问卷,对88 名在校本科护生进行调查并分析其影响因素.结果 经调查本科护生逆境商总分为(134.62±16.56)分,年级、是否曾担任班干部、是否为独生子女及是否参与护理见习实践对护生逆境商影响有统计学意义(P<0.05).结论 在校本科护生应对逆境的能力有待进一步提高,护理教育者可针对其主要影响因素有的放矢,以提高其逆境应对能力.%Objective To understand nursing undergraduates' ability to cope with adversity, to analyze its influencing factors and to provide evidence for taking specific measures to improve students ' ability to cope with adversity. Methods A total of 88 nursing undergraduates were surveyed with Adversity Response Profile (ARP) and a self-designed general information questionnaire. Results The total score of adversity quotient of nursing undergraduates was (134.62±16.56). Grade, class leaders or not and only child or not had significant influence on their adversity quotient (P<0.05). Conclusion Nursing undergraduates' ability to cope with adversity needs to be improved. Effective and personalized strategies should be taken to improve their ability to cope with adversity.

  10. 高压氧辅助治疗突发性耳聋预后的影响因素研究%The Influencing Factors for Prognosis of Sudden Deafness by Hyperbaric Oxygen Assist Therapy

    Institute of Scientific and Technical Information of China (English)

    李琴; 吴嗣洪; 唐守英; 张惠华; 曹晓燕; 葛秀英

    2015-01-01

    目的:探讨高压氧(HBO)辅助治疗突发性耳聋(SD)预后的影响因素,建立预估不良预后的评分系统。方法回顾性选择2008年6月—2013年5月在上海市奉贤区中心医院五官科住院治疗且病历资料完整的SD患者168例,收集患者年龄、合并高血压和/或糖尿病及SD发病、治疗情况。结果 Pearson相关性分析显示,年龄≥50岁、合并高血压和/或糖尿病、发病至就诊时间≥15 d、平均听力损失≥60 dB、听力曲线类型、伴眩晕、发病至开始HBO治疗时间≥15 d 和 HBO 治疗﹤2个疗程与 HBO 辅助治疗 SD 预后有关联( r =-0.247、-0.166、-0.170、-0.441、-0.171、-0.195、-0.234、-0.249,P﹤0.05)。Logistic回归分析显示,合并高血压和/或糖尿病〔OR=5.787,95%CI(1.456,23.001),P=0.013〕、平均听力损失≥60 dB〔OR=26.308,95%CI(7.262,95.302),P﹤0.001〕、听力曲线类型〔OR =21.067,95% CI(5.036,88.131),P ﹤0.001〕、伴眩晕〔OR =7.212,95% CI (1.701,30.573),P=0.007〕、发病至开始HBO治疗时间≥15 d〔OR=52.359,95%CI(11.152,245.831),P﹤0.001〕、HBO治疗﹤2个疗程〔OR=4.685,95%CI(1.364,16.095),P=0.014〕进入回归方程。Logistic回归方程预测患者预后的灵敏度为0.86,特异度为0.91,ROC曲线下面积为0.955(P﹤0.05)。结论合并高血压和/或糖尿病、平均听力损失≥60 dB、听力曲线呈下降/全聋型、SD伴眩晕、HBO开始治疗时间≥15 d、HBO治疗﹤2个疗程是影响HBO辅助治疗SD预后的危险因素,本研究建立的评分对预测患者预后和指导临床治疗有一定参考价值。%Objective To explore the influencing factors for the prognosis of sudden deafness ( SD ) treated by hyperbaric oxygen assist therapy and design a scoring system for predicting poor prognosis. Methods 168 patients with SD who were admitted in Facial Department of

  11. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Caregivers Questions to Ask about Advanced Cancer Research Managing Cancer Care Finding Health Care Services Advance Directives Using Trusted Resources What Is Cancer Cancer Statistics Causes & Prevention Risk Factors Genetics Cancer Prevention Overview Screening Cancer Screening ...

  12. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available Español 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview–for health professionals Research ...

  13. HER-2, p53, p21 and hormonal receptors proteins expression as predictive factors of response and prognosis in locally advanced breast cancer treated with neoadjuvant docetaxel plus epirubicin combination

    International Nuclear Information System (INIS)

    Neoadjuvant chemotherapy has been considered the standard care in locally advanced breast cancer. However, about 20% of the patients do not benefit from this clinical treatment and, predictive factors of response were not defined yet. This study was designed to evaluate the importance of biological markers to predict response and prognosis in stage II and III breast cancer patients treated with taxane and anthracycline combination as neoadjuvant setting. Sixty patients received preoperative docetaxel (75 mg/m2) in combination with epirubicin (50 mg/m2) in i.v. infusion in D1 every 3 weeks after incisional biopsy. They received adjuvant chemotherapy with CMF or FEC, attaining axillary status following definitive breast surgery. Clinical and pathologic response rates were measured after preoperative therapy. We evaluated the response rate to neoadjuvant chemotherapy and the prognostic significance of clinicopathological and immunohistochemical parameters (ER, PR, p51, p21 and HER-2 protein expression). The median patient age was 50.5 years with a median follow up time 48 months after the time of diagnosis. Preoperative treatment achieved clinical response in 76.6% of patients and complete pathologic response in 5%. The clinical, pathological and immunohistochemical parameters were not able to predict response to therapy and, only HER2 protein overexpression was associated with a decrease in disease free and overall survival (P = 0.0007 and P = 0.003) as shown by multivariate analysis. Immunohistochemical phenotypes were not able to predict response to neoadjuvant chemotherapy. Clinical response is inversely correlated with a risk of death in patients submitted to neoadjuvant chemotherapy and HER2 overexpression is the major prognostic factor in stage II and III breast cancer patients treated with a neoadjuvant docetaxel and epirubicin combination

  14. RACIAL RESIDENTIAL SEGREGATION AND ADVERSE BIRTH OUTCOMES

    Science.gov (United States)

    INTRODUCTION. The disparity between black and white women's adverse birth outcomes has been subject to much investigation, yet the factors underlying its persistence remain elusive, which has encouraged research on neighborhood-level influences, including racial residential segr...

  15. Understanding Cancer Prognosis

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    Full Text Available Español 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors ... History Committees of Interest Legislative Resources Recent Public Laws Contact Overview History of NCI Contributing to Cancer ...

  16. Understanding Cancer Prognosis

    Science.gov (United States)

    Español 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ...

  17. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available Español 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ...

  18. Learning from adverse incidents involving medical devices.

    Science.gov (United States)

    Amoore, John; Ingram, Paula

    While an adverse event involving a medical device is often ascribed to either user error or device failure, the causes are typically multifactorial. A number of incidents involving medical devices are explored using this approach to investigate the various causes of the incident and the protective barriers that minimised or prevented adverse consequences. User factors, including mistakes, omissions and lack of training, conspired with background factors--device controls and device design, storage conditions, hidden device damage and physical layout of equipment when in use--to cause the adverse events. Protective barriers that prevented or minimised the consequences included staff vigilance, operating procedures and alarms. PMID:12715578

  19. The influence factors of prognosis in patients with chronic heart failure%慢性心力衰竭患者预后影响因素的调查分析

    Institute of Scientific and Technical Information of China (English)

    陈燕; 吕蓉; 季诗明; 孙路路; 梁涛

    2012-01-01

    目的 探讨慢性心力衰竭(CHF)患者的生存状况及死亡相关危险因素.方法 2008年12月至2010年2月,收集北京阜外心血管病医院CHF监护病房住院的108例患者的基线资料,随访患者出院后6个月的生存状况,以生存状况为因变量进行Logistic回归分析.结果 CHF患者出院后6个月内的病死率为18.5%.多因素非条件Logistic回归分析结果显示,下肢水肿、BMI及明尼苏达生活质量得分与心力衰竭死亡相关,调整OR (95%CI)分别为18.566(1.299~265.408)、0.583(0.404~0.841)、1.075(1.017~1.135).结论 CHF患者的短期病死率较高,营养状况差,生活质量下降,预后较差;入院时水肿等症状明显的患者,短期死亡风险增加.%Objective To investigate the mortality rate and analyze the risk factors of death in patients with chronic heart failure. Methods One hundred and eight patients with heart failure who were discharged from Heart Failure Care Unit of Fuwai Cardiology Hospital were followed up for six months. The influence factors of survival were analyzed by Logistic regression analysis. Results The mortality rate of heart failure patients within six months after discharge was 18.5 percent. Logistic regression analysis indicated that lower limb edema(OR=18.566),BMI(OR=0.583) and quality of life (OR=1.075) were influence factors of death in heart failure patients. Conclusions The mortality rate of heart failure patients is relatively high within six months. The patients' nutritional status,quality of life and prognosis are poor. The clinical symptoms at admission such as lower limb edema are risk factors of death.

  20. Adverse reactions to cosmetics

    OpenAIRE

    Dogra A; Minocha Y; Kaur S

    2003-01-01

    Adverse reaction to cosmetics constitute a small but significant number of cases of contact dermatitis with varied appearances. These can present as contact allergic dermatitis, photodermatitis, contact irritant dermatitis, contact urticaria, hypopigmentation, hyperpigmentotion or depigmentation, hair and nail breakage. Fifty patients were included for the study to assess the role of commonly used cosmetics in causing adverse reactions. It was found that hair dyes, lipsticks and surprisingly ...

  1. Family skills for overcoming adversity

    Directory of Open Access Journals (Sweden)

    Mónica Patricia Ardila Hernández

    2013-12-01

    Full Text Available This section draws on research four families in displacement in Tunja Boyacá step of this research is to present the problem of displacement from another different look that has embargoed regarding this topic. Critical reflection was raised from resilient approach Parsons theory in order to understand families immersed in this conflict as change agents capable of adapting to a new system and overcome adversity. Within this scheme is used to obtain qualitative research of the following categories : adaptation to the new social context risk factors present in families and protective factors.

  2. Peritumoral vascular invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosis

    International Nuclear Information System (INIS)

    Traditional determinants proven to be of prognostic importance in breast cancer include the TNM staging, histological grade, proliferative activity, hormone receptor status and HER2 overexpression. One of the limitations of the histological grading scheme is that a high percentage of breast cancers are still classified as grade 2, a category with ambiguous clinical significance. The aim of this study was to best characterize tumors scored as grade 2. We investigated traditional prognostic factors and a panel of tumor markers not used in routine diagnosis, such as NHERF1, VEGFR1, HIF-1α and TWIST1, in 187 primary invasive breast cancers by immunohistochemistry, stratifying patients into good and poor prognostic groups by the Nottingham Prognostic Index. Grade 2 subgroup analysis showed that the PVI (p = 0.023) and the loss of membranous NHERF1 (p = 0.028) were adverse prognostic factors. Relevantly, 72% of grade 2 tumors were associated to PVI+/membranous NHERF1- expression phenotype, characterizing an adverse prognosis (p = 0.000). Multivariate logistic regression analysis in the whole series revealed poor prognosis correlated with PVI and MIB1 (p = 0.000 and p = 0.001, respectively). Furthermore, in the whole series of breast cancers we found cytoplasmic NHERF1 expression positively correlated to VEGFR1 (r = 0.382, p = 0.000), and in VEGFR1-overexpressing tumors the oncogenic receptor co-localized with NHERF1 at cytoplasmic level. The PVI+/membranous NHERF1- expression phenotype identifies a category of grade 2 tumors with the worst prognosis, including patient subgroup with a family history of breast cancer. These observations support the idea of the PVI+/membranous NHERF1- expression immunophenotype as a useful marker, which could improve the accuracy of predicting clinical outcome in grade 2 tumors

  3. Peritumoral vascular invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosis

    Directory of Open Access Journals (Sweden)

    Malfettone Andrea

    2012-03-01

    Full Text Available Abstract Background Traditional determinants proven to be of prognostic importance in breast cancer include the TNM staging, histological grade, proliferative activity, hormone receptor status and HER2 overexpression. One of the limitations of the histological grading scheme is that a high percentage of breast cancers are still classified as grade 2, a category with ambiguous clinical significance. The aim of this study was to best characterize tumors scored as grade 2. Methods We investigated traditional prognostic factors and a panel of tumor markers not used in routine diagnosis, such as NHERF1, VEGFR1, HIF-1α and TWIST1, in 187 primary invasive breast cancers by immunohistochemistry, stratifying patients into good and poor prognostic groups by the Nottingham Prognostic Index. Results Grade 2 subgroup analysis showed that the PVI (p = 0.023 and the loss of membranous NHERF1 (p = 0.028 were adverse prognostic factors. Relevantly, 72% of grade 2 tumors were associated to PVI+/membranous NHERF1- expression phenotype, characterizing an adverse prognosis (p = 0.000. Multivariate logistic regression analysis in the whole series revealed poor prognosis correlated with PVI and MIB1 (p = 0.000 and p = 0.001, respectively. Furthermore, in the whole series of breast cancers we found cytoplasmic NHERF1 expression positively correlated to VEGFR1 (r = 0.382, p = 0.000, and in VEGFR1-overexpressing tumors the oncogenic receptor co-localized with NHERF1 at cytoplasmic level. Conclusions The PVI+/membranous NHERF1- expression phenotype identifies a category of grade 2 tumors with the worst prognosis, including patient subgroup with a family history of breast cancer. These observations support the idea of the PVI+/membranous NHERF1- expression immunophenotype as a useful marker, which could improve the accuracy of predicting clinical outcome in grade 2 tumors.

  4. Peritonite bacteriana espontânea na cirrose hepática: prevalência, fatores preditivos e prognóstico Spontaneous bacterial peritonitis in hepatic cirrhosis: prevalence, predictive factors and prognosis

    Directory of Open Access Journals (Sweden)

    F.A.F. Figueiredo

    1999-04-01

    investigate prospectively prevalence, predictive factors and prognosis of the episode of SBP, we studied 143 in and outpatients with cirrhosis admitted to HUCFF and HUPE between January, 1995 and January, 1996. All patients were submitted to a questionaire, physical examination, blood analysis and abdominal paracentesis with ascitic fluid analysis. They were followed for a mean follow-up period of 4 months and survival was determined. RESULTS: The prevalence of SBP was 20%. Culture-positive SBP, Culture-negative Neutrocytic Ascites and Bacterascites were identified in 24%, 66% and 10%, respectively. After uni - and multivariate analysis, only anterior gastrointestinal hemorrhage, serum albumin and ascitic fluid C4 reached statistical significance (p=0.05 as predictive factors for the development of the SBP. The in-hospital and follow-up mortality rates were 33.3% and 53.8% for the SBP patients and 8.5% and 31.9% for the non-SBP patients, respectively (p=0.01 and p=0.04. The cumulative probability of survival in the SBP group was significantly lower than the probability of the non-SBP group (p=0.05. CONCLUSIONS: We conclude that SBP is a frequent complication, depends of the severity of liver failure and is a marker for poor prognosis in patients with liver cirrhosis.

  5. Prognosis and influencing factors of retinopathy of prematurity of 145 cases%早产儿视网膜病变145例转归情况及影响因素分析

    Institute of Scientific and Technical Information of China (English)

    王曦琅; 熊师; 罗俊; 吴九菊; 周立军; 王平

    2013-01-01

    AIM: To analyze the prognosis and influencing factors of retinopathy of prematurity (ROP).METHODS: The prognosis of 145 ROP cases treated in our hospital from September 2011 to September 2012 was recorded (110 males, 35 females). Gestational weeks, birth weight, time of oxygen, oxygen [ continuous positive airway pressure ( CPAP ) or mechanical ventilation ], pulmonary surfactant, septicemia were statistically analyzed between surgical group and non -surgical group.RESULTS: A total of 145 cases of retinopathy of premature were all in stage 1 to 3, no cases in 4 to 5 stage. Thirty-six cases (24.8%) had undergone the laser and/orcryocoagulation. ROP regressed completely or were stable before prethreshold lesions without surgery in 109 cases (75. 2%). Using the Chi - square test, multivariate logistic regression analysis, it showed that gestational age, time of oxygen, CPAP or mechanical ventilation and septicemia were associated with ROP outcome, with the statistically significant difference. Gestational age, oxygen, septicemia were progression factors of ROP, which was significant difference between groups.CONCLUSION: Most of ROP degenerated or were stable without surgery. Gestational age, mechanical ventilation or CPAP, oxygen for a long time, septicemia could aggravate ROP and increase the probability of surgery.%目的:分析早产儿视网膜病变(ROP)的转归情况,了解影响ROP转归的因素.方法:2011-09/2012-09我院新生儿监护病房住院诊断为ROP的患儿共145例,其中男110例,女35例,记录其转归情况,对手术组与非手术组的孕周、出生体质量、吸氧时间、吸氧方式(持续正压通气(CPAP)或机械通气)、肺表面活性物质应用、败血症进行统计学分析.结果:早产儿视网膜病变145例为1~3期患儿,无1例4~5期病变,36例(24.8%)行视网膜光凝或(和)冷凝,109例(75.2%)患儿完全自然退变或阈值前病变病情稳定未手术.采用卡方检验单因素分析及多因素Logistic回

  6. 髓母细胞瘤复发、播散性种植及预后的相关因素分析%Analysis on correlation factors of relapse,metastasis and prognosis of medulloblastoma

    Institute of Scientific and Technical Information of China (English)

    宋飞; 许百男; 张军

    2014-01-01

    目的:探讨影响髓母细胞瘤术后局部复发、播散性种植和预后的临床因素。方法回顾性分析我科收治并经病理确认的43例髓母细胞瘤患者,采用Log-Rank法分析肿瘤的T分期、切除程度、放疗方式对患者术后肿瘤复发、播散性种植及生存时间的影响。结果获得随访的41例患者中,3年、5年总体生存率分别为68.3%、50.1%,肿瘤的T分期、切除程度、放疗方式对患者术后复发时间、术后总生存时间的影响均存在统计学差异;肿瘤的T分期、放疗方式对患者播散性种植时间的影响存在统计学差异,而切除程度对其影响无明显统计学差异。结论处于T1、T2期的肿瘤、接受全脑-脊髓放疗的患者手术距离发生复发、播散性种植的时间和术后总生存时间较长,手术全切除能延缓术后复发和延长术后生存时间,但对发生播散性种植的时间无影响。%Objective To discuss the factors that influence the local relapse , implantative metastasis,post operational prognosis of patients suffering from medulloblastoma (MB).Methods The data of 43 patients with MB treated in our department were retrospectively analyzed with Log -Rank test to estimate effects of T stage , extent of resection and radiotherapy on local relapse , implantative metastasis, post operational prognosis .Results The overall three-year,five-year survival rates were 68.3%and 50.1% respectively .The factors that were significantly associated with post operational local recurrences and overall survival time were tumor T stage ,extent of resection and radiotherapy . The differences between tumor T stages ,radiotherapy were significant in implantative metastasis ,while the difference between extents of resection was not .Conclusions Patients with a tumor of T1 or T2 stage and those received post operational craniospinal irradiation have longer recurrence -free time, metastasis-free time and overall

  7. Baseline leukocyte count and acute coronary syndrome: predictor of adverse cardiac events, long and short term mortality and association with traditional risk factors, cardiac biomarkers and C-reactive protein

    International Nuclear Information System (INIS)

    The elevated WBC count has been accepted as part of healing response following myocardial infarction as well as a predictor of adverse cardiovascular events. The study was designed to find out correlation between WBC count and coronary risk factors, cardiac biomarkers, C-reactive protein (CRP), incidence of adverse cardiac events and mortality in patients of ACS in Pakistan. Methods: One hundred and thirty-three patients of ACS were stratified according to WBC categories, WBC1 (10,000/mm/sup 3/). The WBCs were counted on admission by Sysmex cell counter, CRP by immunoturbidimetric method, and CK-MB and Trop-I by enzyme immunoassay. Adverse cardiac events and mortality were recorded for 12 months of follow up period. Results: Long term mortality in patients with ACS was 6.4% in WBC1, 18.2% in WBC2 and 40.9% in WBC3 categories, while short term mortality was 2.6%, 3.0% and 18.2% in WBC1, WBC2, and WBC3 categories respectively. Relative to patients in lower 2 WBC categories, patients in the highest category were 7 times more likely to die during 30 days (HR 7.83, p=0.017) and more than 9 times during the total follow up period (HR 9.42, p<0.001). Cox regression analysis showed WBC3 a strong independent predictor of mortality (HR 6.36, p=0.016). WBC count showed a positive correlation with coronary risk factors, cardiac biomarkers and CRP. Conclusion: WBC count is a strong independent predictor of mortality in patients with ACS and has positive correlation with coronary risk factors, cardiac biomarkers and CRP. (author)

  8. Incidence and risk factors for new-onset diabetes in HIV-infected patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study

    DEFF Research Database (Denmark)

    De Wit, Stephane; Sabin, Caroline A; Weber, Rainer;

    2008-01-01

    OBJECTIVE: The aims of this study were to determine the incidence of diabetes among HIV-infected patients in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) cohort, to identify demographic, HIV-related, and combination antiretroviral therapy (cART)-related factors associated with...... the onset of diabetes, and to identify possible mechanisms for any relationships found. RESEARCH DESIGN AND METHODS: D:A:D is a prospective observational study of 33,389 HIV-infected patients; diabetes is a study end point. Poisson regression models were used to assess the relation between diabetes...

  9. Nuclear detection of Y-box protein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer

    International Nuclear Information System (INIS)

    Y-box binding protein-1 (YB-1) is the prototypic member of the cold shock protein family that fulfills numerous cellular functions. In the nucleus YB-1 protein orchestrates transcription of proliferation-related genes, whereas in the cytoplasm it associates with mRNA and directs translation. In human tumor entities, such as breast, lung and prostate cancer, cellular YB-1 expression indicates poor clinical outcome, suggesting that YB-1 is an attractive marker to predict patients' prognosis and, potentially, is suitable to individualize treatment protocols. Given these predictive qualities of YB-1 detection we sought to establish a highly specific monoclonal antibody (Mab) for diagnostic testing and its characterization towards outcome prediction (relapse-free and overall survival). Hybridoma cell generation was carried out with recombinant YB-1 protein as immunogen and Mab characterization was performed using immunoblotting and ELISA with recombinant and tagged YB-1 proteins, as well as immunohistochemistry of healthy and breast cancer specimens. Breast tumor tissue array staining results were analyzed for correlations with receptor expression and outcome parameters. YB-1-specific Mab F-E2G5 associates with conformational binding epitopes mapping to two domains within the N-terminal half of the protein and detects nuclear YB-1 protein by immunohistochemistry in paraffin-embedded breast cancer tissues. Prognostic evaluation of Mab F-E2G5 was performed by immunohistochemistry of a human breast cancer tissue microarray comprising 179 invasive breast cancers, 8 ductal carcinoma in situ and 37 normal breast tissue samples. Nuclear YB-1 detection in human breast cancer cells was associated with poor overall survival (p = 0.0046). We observed a close correlation between nuclear YB-1 detection and absence of progesterone receptor expression (p = 0.002), indicating that nuclear YB-1 detection marks a specific subgroup of breast cancer. Likely due to limitation of sample

  10. Analysis of influence factors of the common adverse reactions after high -dose methotrexate chemotherapy%甲氨蝶呤化疗常见不良反应的影响因素分析

    Institute of Scientific and Technical Information of China (English)

    王轶睿; 王捷; 安琳娜; 曹红; 武云

    2016-01-01

    Objective To evaluate the influence factors of common adverse reactions after high -dose methotrexate chemotherapy , and to provide basis for safe and rational clinical use of methotrexate.Methods Treatment protocols were referred to collaborative group of adults acute lymphoblastic leukemia ( CALLG2008 ) protocol, diagnosis and treatment of childhood acute lymphoblastic leukemia recommenda-tions, Hyper -CVAD protocol , improvement Bonn protocol , BFM90 protocol.Basic information , blood routine and biochemistry tests , metho-trexate plasma concentration , MTHFR C677 T gene polymorphism detec-tion results , and adverse reactions during the chemotherapy were collect-ed, and then analyzed the impact of fixed effect factors on adverse reac-tions by non -conditional Logistic regression.Results A total of 112 cases of patients with lymphatic cancer were recruited.Mucosal lesions , bone marrow suppression and anemia were mainly adverse reactions.Occurrence of oral mucositis was affected by patients ’ gender , weight and MTHFR gene type , while the incidence of anemia and bone marrow suppression after chemotherapy was affected by patients ’ weight and MTHFR gene type.Conclusion The impact factors of adverse reactions in chemotherapy of high -dose methotrexate were complicated , conducting relevant researches on influence factors of adverse reactions can provide foundation for individualized chemotherapy of high -dose methotrexate.%目的:观察大剂量甲氨蝶呤化疗后常见不良反应的影响因素,为临床安全合理使用甲氨蝶呤提供依据。方法大剂量甲氨蝶呤治疗方案参照急性淋巴细胞白血病治疗方案( CALLG2008)、儿童急性淋巴细胞白血病诊疗建议、Hyper-CVAD方案、改良Bonn方案及BFM90方案。收集患者大剂量甲氨蝶呤化疗期间基本资料、血液学和生化常规检查、甲氨蝶呤血药浓度、MTHFR C677T基因多态性检测结果及化疗后不良反应监测结果,非条

  11. Quality of life in patients with schizophrenia: the impact of socio-economic factors and adverse effects of atypical antipsychotics drugs.

    Science.gov (United States)

    de Araújo, Aurigena Antunes; de Araújo Dantas, Diego; do Nascimento, Gemma Galgani; Ribeiro, Susana Barbosa; Chaves, Katarina Melo; de Lima Silva, Vanessa; de Araújo, Raimundo Fernandes; de Souza, Dyego Leandro Bezerra; de Medeiros, Caroline Addison Carvalho Xavier

    2014-09-01

    This cross-sectional study compared the effects of treatment with atypical antipsychotic drugs on quality of life (QoL) and side effects in 218 patients with schizophrenia attending the ambulatory services of psychiatric in Rio Grande do Norte, Brazil. Socio-economic variables were compared. The five-dimension EuroQoL (EQ-5D) was used to evaluate QoL, and side effects were assessed using the Udvalg for Kliniske Undersøgelser (UKU) Side Effect Rating Scale and the Simpson-Angus Scale. Data were analysed using the χ (2) test and Student's t test, with a significance level of 5 %. Average monthly household incomes in the medication groups were 1.1-2.1 minimum wages ($339-$678). UKU Scale scores showed significant differences in side effects, mainly, clozapine, quetiapine and ziprasidone (p < 0.05). EQ-5D scores showed that all drugs except olanzapine significantly impacted mobility (p < 0.05), and proportions of individuals reporting problems in other dimensions were high: 63.6 % of clozapine users reported mobility problems, 63.7 and 56.3 % of clozapine and ziprasidone users, respectively, had difficulties with usual activities, 68.8 and 54.5 % of ziprasidone and clozapine users, respectively, experienced pain and/or discomfort, and 72.8 % of clozapine users reported anxiety and/or depression. Psychiatric, neurological, and autonomous adverse effects, as well as other side effects, were prevalent in users of atypical antipsychotic drugs, especially clozapine and ziprasidone. Olanzapine had the least side effects. QoL was impacted by side effects and economic conditions in all groups. Thus, the effects of these antipsychotic agents appear to have been masked by aggravating social and economic situations. PMID:24789610

  12. Allogeneic bone marrow transplantation for severe aplastic anemia patients with risk factors for poor prognosis: is fludarabine a requirement? Transplante alogênico de medula óssea em portadores de anemia aplásica severa com fatores de mau prognóstico: é necessário fludarabina?

    OpenAIRE

    Carlos R. de Medeiros; Elenaide Coutinho; Eliane R. Carmes; Marco A. Bitencourt; Jefferson Ruiz; Carmen S. Bonfim; Vaneusa M. Funke; Daniela C. Setubal; José Zanis-Neto; Ricardo Pasquini

    2008-01-01

    Hematopoietic progenitor cell transplantation from HLA-identical sibling donors cures 70-90% of Severe Aplastic Anemia (sAA) patients. Older age, heavy exposure to transfusions, immunosuppression treatment (IST) with a long interval from diagnosis to transplant and infection at procedure are associated with poor outcomes. We transplanted 18 patients with sAA and at least one risk factor (RF) for poor prognosis (age >35 years, >50 transfusions prior to transplant, unresponsiveness to previous ...

  13. 重症急性肾功能衰竭预后影响因素分析%Analysis of risk factors determining prognosis of 100 critically ill patients with severe acute renal failure

    Institute of Scientific and Technical Information of China (English)

    王涌; 向晶; 马志芳; 张冬; 孙雪峰; 陈香美

    2011-01-01

    目的 了解影响重症急性肾功能衰竭患者预后的主要危险因素.方法 总结2008年1月至2009年12月解放军总医院收治的进行肾脏替代治疗的100例重症急性肾功能衰竭患者的临床数据,采用APACHEⅡ评分评估患者病情严重程度,SOFA评分评估患者重要器官功能,采用单因素分析和多因素Logistic回归方法分析影响患者肾功能恢复的因素,应用Kaplan-Meier 生存分析和COX比例风险模型分析患者累积存活率和影响患者生存的主要因素.结果 伴有呼吸衰竭的患者存活率低于无呼吸衰竭患者(P=0.016);肝脏SOFA积分≥2的患者存活率低于肝脏SOFA积分<2患者(P=0.011);APACHE Ⅱ评分>25的患者存活率明显低于APACHⅡ评分≤25患者(P=0.001) APACHE Ⅱ评分是影响患者病死率的因素(P<0.01,95%CI:1.048~1.076).结论 APACHⅡ评分高低是影响重症急性肾功能衰竭惠者肾功能恢复和最终死亡的主要因素,避免呼吸衰竭、脓毒症的发生及肝功能的恶化,有利于降低患者病死率.%Objective To learn risk factors associated with prognosis of critically ill patients with severe acute renal failure (sARF). Methods Clinical records of 100 patients with acute renal failure performed renal replacement therapy (RRT) were collected and patients were prospectively followed up for 3 ~ 320 days. Severity of illness was assessed using the Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ score and Sepsisrelated Organ Failure Assessment (SOFA) score. Univariate analysis and multivariable Logistic regression model were developed to assess factors associated with recovery of renal function. Kaplan-Meier survival analysis and Cox proportional hazard model were developed to assess factors affecting survival rate of patients. Results Lower APACHE Ⅱ score and SOFA score of liver≥2 were independently associated with renal recovery in the multivariate analysis( P <0. 05). Survival rate of

  14. Clarifying Associations between Childhood Adversity, Social Support, Behavioral Factors, and Mental Health, Health, and Well-Being in Adulthood: A Population-Based Study

    Science.gov (United States)

    Sheikh, Mashhood A.; Abelsen, Birgit; Olsen, Jan A.

    2016-01-01

    Previous studies have shown that socio-demographic factors, childhood socioeconomic status (CSES), childhood traumatic experiences (CTEs), social support and behavioral factors are associated with health and well-being in adulthood. However, the relative importance of these factors for mental health, health, and well-being has not been studied. Moreover, the mechanisms by which CTEs affect mental health, health, and well-being in adulthood are not clear. Using data from a representative sample (n = 12,981) of the adult population in Tromsø, Norway, this study examines (i) the relative contribution of structural conditions (gender, age, CSES, psychological abuse, physical abuse, and substance abuse distress) to social support and behavioral factors in adulthood; (ii) the relative contribution of socio-demographic factors, CSES, CTEs, social support, and behavioral factors to three multi-item instruments of mental health (SCL-10), health (EQ-5D), and subjective well-being (SWLS) in adulthood; (iii) the impact of CTEs on mental health, health, and well-being in adulthood, and; (iv) the mediating role of adult social support and behavioral factors in these associations. Instrumental support (24.16%, p Psychological abuse was relatively more important for mental health (12.13%), health (7.01%), and well-being (9.09%), as compared to physical abuse, and substance abuse distress. The subjective assessment of childhood financial conditions was relatively more important for mental health (6.02%), health (10.60%), and well-being (20.60%), as compared to mother's and father's education. CTEs were relatively more important for mental health, while, CSES was relatively more important for health and well-being. Respondents exposed to all three types of CTEs had a more than two-fold increased risk of being mentally unhealthy (RRTotal Effect = 2.75, 95% CI: 2.19–3.10), an 89% increased risk of being unhealthy (RRTotal Effect = 1.89, 95% CI: 1.47–1.99), and a 42% increased

  15. 感染性心内膜炎患者临床特征与预后影响因素分析%Clinical characteristics and influencing factors of prognosis of infective endocarditis

    Institute of Scientific and Technical Information of China (English)

    张苑; 任鹏涛; 杨婧; 刘婷婷; 闫庆辉; 张国建

    2016-01-01

    OBJECTIVE To investigate the clinical characteristics and prognostic factors of infective endocarditis ,so as to provide basis for improving the prognosis of patients with endocarditis .METHODS A total of 900 patients with infective endocarditis in the hospital from Jan .2010 to Dec .2014 were selected ,and their clinical data were retrospectively analyzed .Clinical characteristics of the patients and their performance were analyzed .The prognos‐tic factors were analyzed by univariate and multivariate logistic regression analyses ,the results were statistically analyzed by using SPSS 20 .0 software .RESULTS Totally 869 patients had underlying heart diseases among the 900 patients with infective endocarditis ,accounting for 96 .56% .The univariate analysis showed artificial valve , fever ≥39 ℃ ,hypersensitive C‐reactive protein ≥60 mg/L ,hemoglobin <90 g/L ,serum albumin <30 g/L and surgical treatment were the related prognostic factors (P< 0 .05) .The multivariate logistic regression analysis showed that hemoglobin <90 g/L ,serum albumin <30g/L and surgical treatment were the independent prognos‐tic factors (P<0 .05) .CONCLUSION The results show that most patients with infective endocarditis have under‐lying heart diseases ,the majority of patients have normal ECG .Levels of hemoglobin and serum albumin as well as surgical treatment are prognostic risk factors in infective endocarditis .%目的:探讨感染性心内膜炎患者的临床特征及预后影响因素,为提高心内膜炎患者预后提供参考依据。方法回顾性分析2010年1月-2014年12月医院收治的900例感染性心内膜炎患者临床资料,分析患者的临床特征及表现,预后影响因素进行单因素及多因素logistic回归分析,结果采用SPSS 20.0软件进行统计分析。结果900例感染性心内膜炎患者中有基础心脏疾病患者869例占96.56%;单因素分析显示,人工瓣膜、发热≥39

  16. Scientists Trace Adversity's Toll

    Science.gov (United States)

    Sparks, Sarah D.

    2012-01-01

    The stress of a spelling bee or a challenging science project can enhance a student's focus and promote learning. But the stress of a dysfunctional or unstable home life can poison a child's cognitive ability for a lifetime, according to new research. Those studies show that stress forms the link between childhood adversity and poor academic…

  17. Adverse Effects of Electroconvulsive Therapy.

    Science.gov (United States)

    Andrade, Chittaranjan; Arumugham, Shyam Sundar; Thirthalli, Jagadisha

    2016-09-01

    Electroconvulsive therapy (ECT) is an effective treatment commonly used for depression and other major psychiatric disorders. We discuss potential adverse effects (AEs) associated with ECT and strategies for their prevention and management. Common acute AEs include headache, nausea, myalgia, and confusion; these are self-limiting and are managed symptomatically. Serious but uncommon AEs include cardiovascular, pulmonary, and cerebrovascular events; these may be minimized with screening for risk factors and by physiologic monitoring. Although most cognitive AEs of ECT are short-lasting, troublesome retrograde amnesia may rarely persist. Modifications of and improvements in treatment techniques minimize cognitive and other AEs. PMID:27514303

  18. Adverse Stress, Hippocampal Networks, and Alzheimer's Disease

    OpenAIRE

    Rothman, Sarah M.; Mattson, Mark P.

    2009-01-01

    Recent clinical data have implicated chronic adverse stress as a potential risk factor in the development of Alzheimer's disease (AD) and data also suggest that normal, physiological stress responses may be impaired in AD. It is possible that pathology associated with AD causes aberrant responses to chronic stress, due to potential alterations in the hypothalamic-pituitary-adrenal (HPA) axis. Recent work in rodent models of AD suggests that chronic adverse stress exacerbates the cognitive def...

  19. Reported health, lifestyles, and use of health care of first generation immigrants in The Netherlands: do socioeconomic factors explain their adverse position?

    OpenAIRE

    Reijneveld, S.A.

    1998-01-01

    OBJECTIVE: Differences in health, lifestyles, and use of health care between groups of varying ethnic origin can have important implications for preventive and curative health care. This paper studies whether socioeconomic factors explain ethnic differences in these outcomes. DESIGN: Data on health status, lifestyles, and use of health care were obtained from interviews with 3296 people aged 16-64 years (response: 60.6%), among whom were 848 first generation immigrants. Ethnic differenc...

  20. Early life adversities or high fat diet intake reduce cognitive function and alter BDNF signaling in adult rats: Interplay of these factors changes these effects.

    Science.gov (United States)

    Arcego, Danusa Mar; Krolow, Rachel; Lampert, Carine; Toniazzo, Ana Paula; Berlitz, Carolina; Lazzaretti, Camilla; Schmitz, Felipe; Rodrigues, André Felipe; Wyse, Angela T S; Dalmaz, Carla

    2016-05-01

    Environmental factors, like early exposure to stressors or high caloric diets, can alter the early programming of central nervous system, leading to long-term effects on cognitive function, increased vulnerability to cognitive decline and development of psychopathologies later in life. The interaction between these factors and their combined effects on brain structure and function are still not completely understood. In this study, we evaluated long-term effects of social isolation in the prepubertal period, with or without chronic high fat diet access, on memory and on neurochemical markers in the prefrontal cortex of rats. We observed that early social isolation led to impairment in short-term and working memory in adulthood, and to reductions of Na(+),K(+)-ATPase activity and the immunocontent of phospho-AKT, in prefrontal cortex. Chronic exposure to a high fat diet impaired short-term memory (object recognition), and decreased BDNF levels in that same brain area. Remarkably, the association of social isolation with chronic high fat diet rescued the memory impairment on the object recognition test, as well as the changes in BDNF levels, Na(+),K(+)-ATPase activity, MAPK, AKT and phospho-AKT to levels similar to the control-chow group. In summary, these findings showed that a brief social isolation period and access to a high fat diet during a sensitive developmental period might cause memory deficits in adulthood. On the other hand, the interplay between isolation and high fat diet access caused a different brain programming, preventing some of the effects observed when these factors are separately applied. PMID:26948152

  1. Analysis of the prognosis-related factors and therapy for elderly patients with diffuse large B-cell lymphoma%老年弥漫性大B细胞淋巴瘤预后因素及治疗分析

    Institute of Scientific and Technical Information of China (English)

    沈琳; 王振荣; 张洪娣; 沙颖豪; 谢彦晖

    2013-01-01

    Objective To discuss the prognosis-related factors for elderly patients with diffuse large B-cell lymphoma and survival analysis of different therapy. Methods We retrospectively analyzed the clinical data from 72 elderly patients with initial diffuse large B-cell lymphoma. The evaluable 64 cases were eligible. The parameters included gender, age, clinical stage, B symptom, ECOG performance status (ECOG-PS), extra lymphnodes invasion, serum level of lactate dehydrogenase (LDH), hemoglobin level, international prognostic index (IPI). The survival analysis and Cox proportional hazards regression model were conducted. To We also compared the survival of 34 patients who received 3-week CHOP chemotherapy and 30 patients 3-week R-CHOP chemotherapy. Results The median follow-up of the total study population was 40.3 months. The estimated 2-year overall survival (OS) of all patients was 67.43%, the estimated 3-year OS was 49.89%. In the multivariate analysis that include age, clinical stage, ECOG-PS, IPI were the independent factor predicting overall survival (P< 0.05). The estimated 2-year OS (53.3% vs 72.1%, P< 0.05) and 3-year OS (39.2%vs60.8%, P< 0.05) had significant difference between CHOP and R-CHOP group. Conclusion Age, clinical stage, ECOG-PS, IPI were independent predictive and prognostic factor in elderly patients with DLBCL. R-CHOP chemotherapy has more advantages than CHOP chemotherapy in survival.%目的 探讨老年弥漫性大B细胞淋巴瘤(DLBCL)预后因素,不同治疗方案对其生存的影响.方法 回顾性分析72例初发老年DLBCL的性别、年龄、临床分期、B症状、ECOG-PS评分、结外病灶、血清LDH水平、血红蛋白水平、IPI评分与预后的相关性,其中可评价的为64例.比较接受3周CHOP方案34例和接受3周R-CHOP方案30例的生存情况.结果 老年DLBCL患者中位生存期40.3个月,2年OS率67.43%,3年OS率49.89%.多因素分析显示年龄、ECOG-PS、临床分期、IPI评分是影响老

  2. Factores de pronóstico relacionados con la mortalidad por neumonía asociada a ventilación mecánica Prognosis factors related to mortality due to pneumonia associated to mechanical ventilation

    OpenAIRE

    Zadis Navarro Rodríguez; Jeisa Rosa Safonts Ferrer; Yanisleidis Guibert Usatorres; Mercedes del Rosario Porto Castellanos

    2013-01-01

    Se realizó un estudio observacional, analítico y retrospectivo de 45 pacientes con neumonía asociada a ventilación mecánica, atendidos en la Unidad de Cuidados Intensivos del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora Torres" de Santiago de Cuba, desde mayo de 2011 hasta igual mes de 2012, con vistas a identificar los factores de pronóstico relacionados con la mortalidad por esa causa. No hubo asociación estadística entre el número de muertes por neumonía y la presencia de ...

  3. 影响毛细血管渗漏综合征预后的因素分析%Influence factors on prognosis of the patients with capillary leak syndrome

    Institute of Scientific and Technical Information of China (English)

    苏俊; 王锦权; 陶晓根; 刘宝; 莫宝定; 张霖

    2012-01-01

    Objective To discuss influence factors on prognosis of the patients with capillary leak syndrome (CLS) in ICU.Methods The clinical data of 191 patients with CLS in ICU were reviewed,and the patients were divided into three groups according to prognosis:death group ( n =37),cured group ( n =132) and non-healed group (n =22).The clinical data of death group were compared with those of cured group at admission,during the course of CLS and before discharging from hospital.Results Compared with the cured group,the central venous pressure and serum albumin decreased ( P < 0.01 ) ; anion gap,triglycerides,pressure adjusted heart rate (PAHR) and oxygenation index were lower ( P < 0.01 or P < 0.05) ; serum glucose and SIRS score increased ( P < 0.01 ) in death group.There was higher rate of poor renal function at admission in death group than that in other groups ( P < 0.01 ).There were more many patients treated with intravenous administration of hydroxyethyl starch,ulinastatin and continuous blood filtration therapy in cured group than those in other groups ( P < 0.05).Conclusions The factors influencing the outcomes of the patients with CLS were hypovolemia,severe hypoproteinemia,interior milieu disorder,malnutrition,hypoxemia,renal injury and severe systemic inflammatory response.The outcomes of patients with CLS in ICU could be improved by using hydroxyethyl starch,ulinastatin and continuous blood filtration therapy.%目的 探讨影响毛细血管渗漏综合征(CLS)患者预后的相关因素.方法 对安徽省立医院重症医学科收治的191例出现CLS患者的临床资料进行回顾性分析,按疾病转归将患者分为3组:死亡组37例,治愈组132例,未愈组22例.将治愈组和死亡组患者在入院时、出现CLS时和出院前的各项临床资料进行比较,探寻影响患者预后的相关因素.结果 与治愈组比较,死亡组患者的中心静脉压、血清白蛋白明显降低(P<0.01),阴离子间隙、甘油三酯、压

  4. Social inhibition modulates the effect of negative emotions on cardiac prognosis following percutaneous coronary intervention in the drug-eluting stent era

    DEFF Research Database (Denmark)

    Denollet, Johan; Pedersen, Susanne S.; Ong, Andrew T L;

    2006-01-01

    Negative emotions have an adverse effect on cardiac prognosis. We investigated whether social inhibition (inhibited self-expression in social interaction) modulates the effect of negative emotions on clinical outcome following percutaneous coronary intervention (PCI)....

  5. Adverse reactions to cosmetics

    Directory of Open Access Journals (Sweden)

    Dogra A

    2003-03-01

    Full Text Available Adverse reaction to cosmetics constitute a small but significant number of cases of contact dermatitis with varied appearances. These can present as contact allergic dermatitis, photodermatitis, contact irritant dermatitis, contact urticaria, hypopigmentation, hyperpigmentotion or depigmentation, hair and nail breakage. Fifty patients were included for the study to assess the role of commonly used cosmetics in causing adverse reactions. It was found that hair dyes, lipsticks and surprisingly shaving creams caused more reaction as compared to other cosmetics. Overall incidence of contact allergic dermatitis seen was 3.3% with patients own cosmetics. Patch testing was also done with the basic ingredients and showed positive results in few cases where casual link could be established. It is recommended that labeling of the cosmetics should be done to help the dermatologists and the patients to identify the causative allergen in cosmetic preparation.

  6. Prognosis Among Healthy Individuals Discharged With a Primary Diagnosis of Syncope

    DEFF Research Database (Denmark)

    Ruwald, Martin Huth; Hansen, Morten Lock; Lamberts, Morten;

    2012-01-01

    OBJECTIVE: This study sought to examine the risk of major cardiac adverse events and death in a nationwide cohort of patients without previous comorbidity admitted for syncope. BACKGROUND: Syncope is a common clinical event, but knowledge of prognosis is not fully elucidated in healthy individual...

  7. Prognosis

    DEFF Research Database (Denmark)

    Myers, Jonathan; Brawner, Clinton A; Haykowsky, Mark J F;

    2015-01-01

    benefits of exercise and the mechanisms underlying these benefits. Studies on the outcome benefits of exercise training, including mortality and hospitalization, have been convincing. This article reviews the physiologic benefits of exercise training in HF, studies on exercise training in women, results......Patients with heart failure (HF) were once discouraged from participating in exercise programs because of concerns regarding safety and the potential for harm to an already damaged myocardium. However, studies over the last 3 decades have provided extensive insights into both the health outcome...

  8. Thesis on Adverse Possession

    OpenAIRE

    O'Dwyer, Kathleen

    2009-01-01

    Adverse possession has been described as a “debilitating” experience and acts as a “blunt instrument” of necessary legislation in modern society. It is a device that ends litigation. Legislation for abolition would lead to greater societal difficulties. Statistically land theft is rare and given that ownership of property carries a duty an owner should be vigilant. One sentence on the property folio could alert an owner of the danger of inadequate fencing. Although aspects of notification ...

  9. Adverse effects of benzodiazepines

    OpenAIRE

    Claire Gudex

    1990-01-01

    The growing realisation that the benzodiazepines have potential for causing serious harm has caused concern due to their wide and common use. This has stimulated interest in the costs and benefits of their use. This paper is a review of the adverse effects of benzodiazepines, and concentrates on four areas of particular concern: drug dependence which the consequent withdrawal symptoms; psychological effects while on the drugs; use by the elderly’ and tolerance to the drug effects. Although th...

  10. Fructose Containing Sugars at Normal Levels of Consumption Do Not Effect Adversely Components of the Metabolic Syndrome and Risk Factors for Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Theodore J. Angelopoulos

    2016-03-01

    Full Text Available The objective of the current study was to explore our hypothesis that average consumption of fructose and fructose containing sugars would not increase risk factors for cardiovascular disease (CVD and the metabolic syndrome (MetS. A randomized, double blind, parallel group study was conducted where 267 individuals with BMI between 23 and 35 kg/m2 consumed low fat sugar sweetened milk, daily for ten weeks as part of usual weight-maintenance diet. One group consumed 18% of calories from high fructose corn syrup (HFCS, another group consumed 18% of calories from sucrose, a third group consumed 9% of calories from fructose, and the fourth group consumed 9% of calories from glucose. There was a small change in waist circumference (80.9 ± 9.5 vs. 81.5 ± 9.5 cm in the entire cohort, as well as in total cholesterol (4.6 ± 1.0 vs. 4.7 ± 1.0 mmol/L, p < 0.01, triglycerides (TGs (11.5 ± 6.4 vs. 12.6 ± 8.9 mmol/L, p < 0.01, and systolic (109.2 ± 10.2 vs. 106.1 ± 10.4 mmHg, p < 0.01 and diastolic blood pressure (69.8 ± 8.7 vs. 68.1 ± 9.7 mmHg, p < 0.01. The effects of commonly consumed sugars on components of the MetS and CVD risk factors are minimal, mixed and not clinically significant.

  11. Fructose Containing Sugars at Normal Levels of Consumption Do Not Effect Adversely Components of the Metabolic Syndrome and Risk Factors for Cardiovascular Disease.

    Science.gov (United States)

    Angelopoulos, Theodore J; Lowndes, Joshua; Sinnett, Stephanie; Rippe, James M

    2016-01-01

    The objective of the current study was to explore our hypothesis that average consumption of fructose and fructose containing sugars would not increase risk factors for cardiovascular disease (CVD) and the metabolic syndrome (MetS). A randomized, double blind, parallel group study was conducted where 267 individuals with BMI between 23 and 35 kg/m² consumed low fat sugar sweetened milk, daily for ten weeks as part of usual weight-maintenance diet. One group consumed 18% of calories from high fructose corn syrup (HFCS), another group consumed 18% of calories from sucrose, a third group consumed 9% of calories from fructose, and the fourth group consumed 9% of calories from glucose. There was a small change in waist circumference (80.9 ± 9.5 vs. 81.5 ± 9.5 cm) in the entire cohort, as well as in total cholesterol (4.6 ± 1.0 vs. 4.7 ± 1.0 mmol/L, p < 0.01), triglycerides (TGs) (11.5 ± 6.4 vs. 12.6 ± 8.9 mmol/L, p < 0.01), and systolic (109.2 ± 10.2 vs. 106.1 ± 10.4 mmHg, p < 0.01) and diastolic blood pressure (69.8 ± 8.7 vs. 68.1 ± 9.7 mmHg, p < 0.01). The effects of commonly consumed sugars on components of the MetS and CVD risk factors are minimal, mixed and not clinically significant. PMID:27023594

  12. 父源因素对胎儿生长发育的不良影响研究进展%Advances of the Adverse Effects of Paternal Factors on Fetal Development

    Institute of Scientific and Technical Information of China (English)

    周梦林; 应俊; 陈丹青

    2015-01-01

    The fetal development is closely related with the adverse pregnancy outcomes such as miscarriage, dystocia, congenital malformation, premature baby, low weight baby and so on. It is also a potential predictor of the fetal origin of some adult diseases. Most of the researches on the risk factors affecting fetal development were focused on the mother origin in recent years. The risk factors of father origin can be classified into two groups: the heredity-related factors such as age, diseases, somatotype, lifestyle and environmental exposure which could disturb the integrity of genomics of father origin or the genomic expression; the social and environmental factors such as psychological state, occupation and income which could mainly affect maternal pregnancy environment and life quality. Two kinds of factors can result in abnormal fetal development in uterus, which is related to adverse outcomes of pregnancy. It is benefit for the fetal development and the infant and adult health to offer genetic counseling to those couples with high-risk factors.%胎儿在宫内的生长发育不仅与流产、难产、畸形、早产、低体质量儿等不良妊娠结局密切相关,而且能用于评估成年期罹患某些疾病的风险。近年国内外关于胎儿生长发育的研究大多关注的是母源因素,对父源因素的研究相对较少。父亲影响胎儿发育的主要因素可以分为两类,即包括年龄、疾病、体型、生活方式、暴露环境在内的遗传因素和以心理状态、职业、经济收入为代表的社会环境因素,前者直接影响父源基因的完整性和表达情况,而后者主要影响母体的生活环境和生活质量,这两类因素的不良发展均可能导致胎儿在宫内的生长发育发生异常,从而出现各种不良妊娠结局。

  13. 儿童期急性白血病合并水痘的特点及其高危预后因素的临床分析%Clinical features of chickenpox and high risk factors of prognosis in childhood cases with acute lymphocytic leukemia

    Institute of Scientific and Technical Information of China (English)

    曾慧慧; 程澄; 陈志海; 李兴旺

    2015-01-01

    目的:分析儿童期急性淋巴细胞白血病(ALL)合并水痘的临床特点,探讨与预后相关的高危临床因素。方法对2008年1月1日~2014年12月31日首都医科大学附属北京地坛医院感染中心收治的儿童期ALL合并水痘的患儿及同期随机普通水痘患儿的临床资料进行回顾性对照分析。结果仅5例(31.25%)儿童期ALL患儿合并水痘有明确水痘接触史。13例(81.25%)儿童期ALL患儿合并水痘临床表现为高热,较普通水痘患儿热程长,为(7.38±3.32)d(t =5.575,P <0.05);皮疹结痂时间较长,为(10.92±2.50)d(t=4.928,P<0.05)。100%患儿出现骨髓抑制,其中10例(62.50%)患儿出现粒细胞缺乏,7例(43.75%)出现血小板减少;8例(50.00%)患儿肝功能异常。儿童期ALL患儿合并水痘经抗病毒、对症支持等治疗,临床治愈11例,自动出院4例,死亡1例。儿童期ALL患儿合并水痘临床表现危重和最终死亡者,具有应用静脉药物化疗方案治疗、化疗中或完成静脉化疗1周内罹患水痘、所有病例均出现骨髓抑制粒细胞缺乏且持续较长时间[(10.08±2.77) d]等特点。结论儿童期ALL患儿合并水痘具有临床症状持续时间长、并发骨髓抑制粒细胞减少等特点,经积极抗病毒及对症支持治疗后预后良好。应用静脉药物化疗中或完成化疗1周内罹患水痘、持续性粒细胞缺乏是与儿童期ALL患儿并发水痘预后不良的临床相关因素。%Objective To investigate the clinical features of chickenpox and the high risk factors of the prognosis in childhood patients with acute lymphocytic leukemia (ALL). Methods The clinical characteristics of chickenpox in childhood ALL patients hospitalized in Beijing Ditan Hospital, Capital Medical University, from January 1st, 2008 to December 31st, 2014 were studied, retrospectively, and the features of random ordinary children onset chickenpox

  14. Cardiac adverse effects of naloxone-precipitated morphine withdrawal on right ventricle: Role of corticotropin-releasing factor (CRF) 1 receptor

    International Nuclear Information System (INIS)

    Opioid addiction is associated with cardiovascular disease. However, mechanisms linking opioid addiction and cardiovascular disease remain unclear. This study investigated the role of corticotropin-releasing factor (CRF) 1 receptor in mediating somatic signs and the behavioural states produced during withdrawal from morphine dependence. Furthermore, it studied the efficacy of CRF1 receptor antagonist, CP-154,526 to prevent the cardiac sympathetic activity induced by morphine withdrawal. In addition, tyrosine hydroxylase (TH) phosphorylation pathways were evaluated. Like stress, morphine withdrawal induced an increase in the hypothalamic–pituitary–adrenal (HPA) axis activity and an enhancement of noradrenaline (NA) turnover. Pre-treatment with CRF1 receptor antagonist significantly reduced morphine withdrawal-induced increases in plasma adrenocorticotropic hormone (ACTH) levels, NA turnover and TH phosphorylation at Ser31 in the right ventricle. In addition, CP-154,526 reduced the phosphorylation of extracellular signal-regulated kinase (ERK) after naloxone-precipitated morphine withdrawal. In addition, CP-154,526 attenuated the increases in body weight loss during morphine treatment and suppressed some of morphine withdrawal signs. Altogether, these results support the idea that cardiac sympathetic pathways are activated in response to naloxone-precipitated morphine withdrawal suggesting that treatment with a CRF1 receptor antagonist before morphine withdrawal would prevent the development of stress-induced behavioural and autonomic dysfunction in opioid addicts. - Highlights: • Morphine withdrawal caused an increase in myocardial sympathetic activity. • ERK regulates TH phosphorylation after naloxone-induced morphine withdrawal. • CRF1R is involved in cardiac adaptive changes during morphine dependence

  15. Cardiac adverse effects of naloxone-precipitated morphine withdrawal on right ventricle: Role of corticotropin-releasing factor (CRF) 1 receptor

    Energy Technology Data Exchange (ETDEWEB)

    Navarro-Zaragoza, J.; Martínez-Laorden, E.; Mora, L.; Hidalgo, J.; Milanés, M.V.; Laorden, M.L., E-mail: laorden@um.es

    2014-02-15

    Opioid addiction is associated with cardiovascular disease. However, mechanisms linking opioid addiction and cardiovascular disease remain unclear. This study investigated the role of corticotropin-releasing factor (CRF) 1 receptor in mediating somatic signs and the behavioural states produced during withdrawal from morphine dependence. Furthermore, it studied the efficacy of CRF1 receptor antagonist, CP-154,526 to prevent the cardiac sympathetic activity induced by morphine withdrawal. In addition, tyrosine hydroxylase (TH) phosphorylation pathways were evaluated. Like stress, morphine withdrawal induced an increase in the hypothalamic–pituitary–adrenal (HPA) axis activity and an enhancement of noradrenaline (NA) turnover. Pre-treatment with CRF1 receptor antagonist significantly reduced morphine withdrawal-induced increases in plasma adrenocorticotropic hormone (ACTH) levels, NA turnover and TH phosphorylation at Ser31 in the right ventricle. In addition, CP-154,526 reduced the phosphorylation of extracellular signal-regulated kinase (ERK) after naloxone-precipitated morphine withdrawal. In addition, CP-154,526 attenuated the increases in body weight loss during morphine treatment and suppressed some of morphine withdrawal signs. Altogether, these results support the idea that cardiac sympathetic pathways are activated in response to naloxone-precipitated morphine withdrawal suggesting that treatment with a CRF1 receptor antagonist before morphine withdrawal would prevent the development of stress-induced behavioural and autonomic dysfunction in opioid addicts. - Highlights: • Morphine withdrawal caused an increase in myocardial sympathetic activity. • ERK regulates TH phosphorylation after naloxone-induced morphine withdrawal. • CRF1R is involved in cardiac adaptive changes during morphine dependence.

  16. [Inflammatory Markers and Their RoIe in Assessing Prognosis of patients With Stable Coronary Artery Disease After Coronary Stenting].

    Science.gov (United States)

    Tomilova, D I; Byazrova, F F; Lopukhova, V V; Buza, V V; Karpov, Yu A

    2015-01-01

    In recent years, expanded data have demonstrated the association between increased inflammatory markers and risk of adverse cardiovascular events in patients undergoing percutaneous coronary intervention (PCI) with stent implantation. Particularly, several studies have demonstrated association between increased C-reactive protein (CRP) level and various risk factors of cardiovascular diseases and their complications. The role of CRP in predicting restenosis after implantation of bare metal stents has been proven, but its role in predicting drug-eluting stents restenosis is still unproved. Significant association between increased white blood cells count and risk of development and severity of coronary artery disease and as well as poor prognosis after PCI has also been demonstrated. But erythrocyte sedimentation rate has been studied insufficiently in this regard. According to some studies, including those conducted in our institute, one can suggest an association between eosinophilic inflammatory response, progression of coronary atherosclerosis, and drug-eluting stents restenosis. Identification of factors affecting prognosis of patients with coronary heart disease after PCI will allow determining further strategy of patient management. PMID:27125112

  17. [Adverse reaction of pseudoephedrine].

    Science.gov (United States)

    López Lois, G; Gómez Carrasco, J A; García de Frías, E

    2005-04-01

    We present a case of a 7 years old girl who developed an episode of myoclonic movements and tremors after being medicated with a not well quantified amount of a pseudoephedrine/antihistamine combination. We want to highlight the potential toxicity of pseudoephedrine, usually administered as part of cold-syrup preparations which are used for symptomatic treatment of upper respiratory tract cough and congestion associated with the common cold and allergic rhinitis. Although these products are generally considered to be safe either by physicians and parents, we can't underestimate the potential adverse events and toxic effects that can occur when administering these medications. PMID:15826569

  18. Ambulatory cardiac arrhythmias in relation to mild hypokalaemia and prognosis in community dwelling middle-aged and elderly subjects

    DEFF Research Database (Denmark)

    Mattsson, Nick; Sadjadieh, Golnaz; Kumarathurai, Preman;

    2016-01-01

    AIMS: Severe hypokalaemia can aggravate arrhythmia tendency and prognosis, but less is known about risk of mild hypokalaemia, which is a frequent finding. We examined the associations between mild hypokalaemia and ambulatory cardiac arrhythmias and their prognosis. METHODS AND RESULTS: Subjects f......: In middle-aged and elderly subjects with no manifest heart disease, mild hypokalaemia is associated with increased rate of ventricular but not supraventricular arrhythmias. Hypokalaemia interacts synergistically with increased ventricular ectopy to increase the risk of adverse events....

  19. Early decrease of PSA, a prognosis factor independent from biochemical control in case of remedial radiotherapy after prostatectomy; Baisse precoce du PSA, un facteur pronostique independant de controle biochimique en cas de radiotherapie de rattrapage apres prostatectomie

    Energy Technology Data Exchange (ETDEWEB)

    Blanchard, P.; Bakkour, M.; Chaurin, P.; Negretti, L.; Wibault, P.; Bossi, A. [Institut de cancerologie Gustave-Roussy, Villejuif (France); Crevoisier, R. de [Centre Eugene-Marquis, Rennes (France)

    2011-10-15

    The authors report the analysis of the predictive value of PSA (prostate specific antigen) decrease during a remedial external radiotherapy performed to increase the PSA after a radical prostatectomy. During four years, 136 patients have been treated by external irradiation to obtain a PSA increase after prostatectomy. Different parameters are noticed: initial pathological stage, initial Gleason score, mean time between prostatectomy and external radiotherapy, values of PSA before and after prostatectomy and after radiotherapy. The evolution of PSA could be used for an early identification of patients presenting a pejorative prognosis. Short communication

  20. Course prognosis of cervical osteochondrosis

    Directory of Open Access Journals (Sweden)

    Kolesov V.N.

    2012-06-01

    Full Text Available

    Today we can state that in spite of a considerable number of cervical osteochondrosis studies, there is a lack of research devoted to analysis of its course. There is no correlation between initial expert evaluations of cervical osteo-chondrosis cases and further course of pathological process. Goal of the research is to develop system of course prognosis of cervical osteochondrosis taking into account environmental infuence, heredity, living conditions, psychological profle of patient’s personality. Materials and methods. Dynamics of degenerative-dystrophic changes progressing of cervical vertebrae in 236 patients was analyzed. Results. Received data demonstrated that probability of stage I changing to stage II, III and IV depended on patients’ sex, age and type of labour activity, frequent supercooling and stress. Probability of fast progression of cervical osteochondrosis (5-year cycle of stage I changing to stage III and IV was to a great extent associated with heredity, urban living, presence of endocrine system diseases, syndrome of nonspecifc dysplasia of connective tissue and low indices of quality of life. Conclusion. Proposed system allows making prognosis of morphologic changes in spinal cord, and is based on radiation methods of verifcation without taking into consideration dynamics of neurological symptomatology.

  1. Correlation between related factors and prognosis of the patients with high falling injury%高处坠落伤患者相关因素与预后的关系

    Institute of Scientific and Technical Information of China (English)

    谭宗奎; 黄卫兵; 陈庄洪; 王庆; 蔡贤华; 黄继锋; 刘曦明

    2004-01-01

    than that of the children. The injuries on the hard ground like cement and stones were severer than those on the loose mud ground.CONCLUSION: The injury states, regularities and characteristics vary with different conditions. The falling height and landing position are the main factors to determine the injury pattern and degree. The age and body mass and the ground circumstance have important effects on the injury. The above factors have important significance for the diagnosis, treatment and prognosis of the high falling injury.

  2. Adverse effects of antioxidative vitamins.

    Science.gov (United States)

    Rutkowski, Maciej; Grzegorczyk, Krzysztof

    2012-06-01

    High doses of synthetic antioxidative vitamins: A, E, C and β-carotene are often used on long-term basis in numerous preventive and therapeutic medical applications. Instead of expected health effects, the use of those vitamins may however lead to cases of hypervitaminosis and even to intoxication. The article points out main principles of safety which are to be observed during supplementation with antioxidative vitamins. Toxic effects resulting from erroneous administration of high doses of those substances on organs and systems of the organism are also discussed. Attention is drawn to interactions of antioxidative vitamins with concomitantly used drugs, as well as intensification of adverse effects caused by various exogenous chemical factors. Moreover, the article presents the evaluation of supplementation with these vitamins, which was performed in large studies. PMID:22528540

  3. Adverse reactions to radiopharmaceuticals

    International Nuclear Information System (INIS)

    Full text. An adverse reaction can occur following administration of a radio pharmaceutical, but fortunately reactions are uncommon. They are usually mild and do not require intensive treatment. This is probably related to the fact that only small chemical quantities of material are administered to patients and that only one or a small number of doses are administered. Since symptoms are unrelated to any known pharmacology of the agents, they can be described as Type B reactions according to the classification of Rawlings and Thompson. Types of reaction that occur and possible mechanisms will be described. The reactions most commonly observed are skin rashes and vasomotor symptoms. It is important that, as far as possible, a cause - effect relationship can be established between the administration of the radio pharmaceutical and the symptoms caused. Some classification schemes therefore exclude vasomotor reactions such as hypotension and slow pulse, since such events can arise in a variety of clinical situations unrelated to radio pharmaceutical administration. It is important for nuclear medicine departments to be aware of the nature of reactions such that they can be recognized and appropriate re-assurance and/or prompt treatment can be given to their patients. Radio pharmaceuticals most frequently mentioned in reporting schemes are di phosphonates used for bone imaging. This probably reflect the fact that these agents are the most frequently used in current practice rather than that they cause more reactions. Problems in establishing the overall frequency of adverse reactions to radio pharmaceuticals include the fact that events may not be recognized if they occur after the patient has left the Nuclear Medicine Department and that reactions are never reported. Two recent studies have attempted to obtain more definitive information by performing prospective studies in a large number of departments. A study in the USA found that there was a rate of 2.3 events per

  4. Association between Perception of Prognosis and Spiritual Well-being among Cancer Patients

    Directory of Open Access Journals (Sweden)

    Alehe Seyedrasooly

    2014-02-01

    Full Text Available Introduction: Disclosure of cancer prognosis is one of the most difficult challenges in caring of cancer patients. An exact effect of prognosis disclosure on spiritual well-being of cancer patient was not completely investigated. Therefore, the present study aimed to investigate the relationship between perception of prognosis and spiritual well-being among cancer patients. Methods: In this descriptive-correlational study, which conducted in 2013, two hundred cancer patients referred to Shahid Ghazi Hospital and private offices of two oncologists in Tabriz participated with convenience sampling method. Perception of prognosis was investigated by Perception of Prognosis Inventory and spiritual well-being of cancer patients was investigated by Paloutzian and Ellison Inventory. Data were analyzed using descriptive statistics and Pearson correlation test. Results: Participants reported positive perception about the prognosis of their disease (score 11 from 15 and rated their spiritual well-being as high (score 99 from 120. There was a positive correlation between the perception of prognosis and spiritual health among cancer patients.Conclusion: Disclosure of cancer prognosis has negative effects on cancer patients. This result highlights the importance of considering cultural factors in disclosure of cancer prognosis. According to limitations of the present study approving these results need more studies.

  5. 经皮冠状动脉介入术后再发不良心血管事件的影响因素分析%Analysis of influential factors for recurrent adverse cardiovascular events after percutaneous coronary intervention

    Institute of Scientific and Technical Information of China (English)

    张爱玲; 刘瑶; 杨莉萍; 胡欣

    2014-01-01

    Objective To analyze the influential factors for recurrent adverse cardiovascular events within one year and 15 years after percutaneous coronary intervention( PCI)in patients with coronary atherosclerotic heart disease(CHD). Methods The patients with CHD,who underwent PCI or bypass operation of coronary artery meanwhile in Department of Cardiology,Beijing Hospital from january 1998 to March 2013,had complete medical records and received dual antiplatelet therapy with clopidogrel and aspirin for one year,were enrolled in the study. Patients' specimens of blood were collected and cytochrome P450 (CYP)2C19 genotype associated with metabolism of clopidogrel were detected. The patients were divided into the reference metabolizers group( *1 / *1),intermediate metabolizers group( *1 / *2 and *1 / *3)and slow metabolizers group( *2 / *2,*2 / *3 and *3 / *3)by the results of genotype detection. The situation of recurrent adverse cardiovascular events within one year and 15 years after the first PCI and the correlative factors were analyzed retrospectively. Results A total of 210 patients were enrolled in the study. They comprised of 148 males and 62 females with age 49-84(67 ± 10)years. There were 163 and 47 patients undergoing PCI for the first and second times,respectively. There were 185 and 25 patients undergoing PCI only and bypass operation of coronary artery meanwhile,respectively. There were 158,156,and 91 cases complicated with hypertension,hyperlipoidemia,and diabetes,respectively. The incidence of adverse cardiovascular events in the reference metabolizers group,the intermediate metabolizers group,and the slow metabolizers group within one year after PCI were 13. 3%(13 / 98),24. 7%(23 / 93),and 31. 6%(6 /19),respectively. The incidence of adverse cardiovascular events in the slow metabolizers group and the intermediate metabolizers group were 2. 37 and 1. 86 times of those in the reference metabolizers group, respectively. Carrying CYP2C19*2 or *3 genotype was

  6. Important issues of alcoholic liver disease prognosis

    Directory of Open Access Journals (Sweden)

    S.P. Sernov

    2010-03-01

    Full Text Available Alcoholic liver disease prognosis has not been thoroughly developed yet. The possibility of morphologic prognosis has been limited due to disadvantages of liver biopsy. Insignificant amount of studies is devoted to laboratory methods. prognosis value of serum markers of liver fibrosis at the last cirrhotic stages is widely considered in the medical literature. at the same time the results of treatment are determined by making a diagnosis

  7. Uncertainty Quantification in Fatigue Crack Growth Prognosis

    Directory of Open Access Journals (Sweden)

    Shankar Sankararaman

    2011-01-01

    Full Text Available This paper presents a methodology to quantify the uncertainty in fatigue crack growth prognosis, applied to structures with complicated geometry and subjected to variable amplitude multi-axial loading. Finite element analysis is used to address the complicated geometry and calculate the stress intensity factors. Multi-modal stress intensity factors due to multi-axial loading are combined to calculate an equivalent stress intensity factor using a characteristic plane approach. Crack growth under variable amplitude loading is modeled using a modified Paris law that includes retardation effects. During cycle-by-cycle integration of the crack growth law, a Gaussian process surrogate model is used to replace the expensive finite element analysis. The effect of different types of uncertainty – physical variability, data uncertainty and modeling errors – on crack growth prediction is investigated. The various sources of uncertainty include, but not limited to, variability in loading conditions, material parameters, experimental data, model uncertainty, etc. Three different types of modeling errors – crack growth model error, discretization error and surrogate model error – are included in analysis. The different types of uncertainty are incorporated into the crack growth prediction methodology to predict the probability distribution of crack size as a function of number of load cycles. The proposed method is illustrated using an application problem, surface cracking in a cylindrical structure.

  8. Peripheral Vascular Disease–Related Procedures in Dialysis Patients: Predictors and Prognosis

    OpenAIRE

    Plantinga, Laura C; Fink, Nancy E.; Coresh, Josef; Stephen M Sozio; Parekh, Rulan S.; Melamed, Michal L.; Powe, Neil R.; Jaar, Bernard G.

    2009-01-01

    Background and objectives: Peripheral vascular disease (PVD) is prevalent among dialysis patients, and many dialysis patients undergo PVD-related procedures. We aimed to examine the risk factors for and prognosis after such procedures in the dialysis setting.

  9. PROGNOSIS OF PRIMARY NON-HODGKIN’S LYMPHOMAS OF THE ORGAN OF VISION

    Directory of Open Access Journals (Sweden)

    Ye. Ye. Grishina

    2012-01-01

    Full Text Available Much attention has been recently given to the prognosis of extranodal non-Hodgkin’s lymphomas (NHL. All currently available prognostic scales fail to fully characterize the prognosis of primary NHL of the eye and its accessory apparatus.The purpose of this study was to identify prognostic factors for vision and life in patients with primary NHL of the organ of vision. Retrospective and prospective studies of the specific features of the disease in 94 patients with primary NHL of the organ of vision revealed some factors influencing its prognosis.

  10. Matrix-Gla protein promotes osteosarcoma lung metastasis and associates with poor prognosis.

    Science.gov (United States)

    Zandueta, Carolina; Ormazábal, Cristina; Perurena, Naiara; Martínez-Canarias, Susana; Zalacaín, Marta; Julián, Mikel San; Grigoriadis, Agamemnon E; Valencia, Karmele; Campos-Laborie, Francisco J; Rivas, Javier De Las; Vicent, Silvestre; Patiño-García, Ana; Lecanda, Fernando

    2016-08-01

    Osteosarcoma (OS) is the most prevalent osseous tumour in children and adolescents and, within this, lung metastases remain one of the factors associated with a dismal prognosis. At present, the genetic determinants driving pulmonary metastasis are poorly understood. We adopted a novel strategy using robust filtering analysis of transcriptomic profiling in tumour osteoblastic cell populations derived from human chemo-naive primary tumours displaying extreme phenotypes (indolent versus metastatic) to uncover predictors associated with metastasis and poor survival. We identified MGP, encoding matrix-Gla protein (MGP), a non-collagenous matrix protein previously associated with the inhibition of arterial calcification. Using different orthotopic models, we found that ectopic expression of Mgp in murine and human OS cells led to a marked increase in lung metastasis. This effect was independent of the carboxylation of glutamic acid residues required for its physiological role. Abrogation of Mgp prevented lung metastatic activity, an effect that was rescued by forced expression. Mgp levels dramatically altered endothelial adhesion, trans-endothelial migration in vitro and tumour cell extravasation ability in vivo. Furthermore, Mgp modulated metalloproteinase activities and TGFβ-induced Smad2/3 phosphorylation. In the clinical setting, OS patients who developed lung metastases had high serum levels of MGP at diagnosis. Thus, MGP represents a novel adverse prognostic factor and a potential therapeutic target in OS. Microarray datasets may be found at: http://bioinfow.dep.usal.es/osteosarcoma/ Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. PMID:27172275

  11. Predisposing factors for serum sodium disturbance in patients with severe traumatic brain injury (SBI)

    OpenAIRE

    Abrishamkar, Saeid; Safavi, Mohammadreza; TAVAKOLI, Pouria; MORADI, Daruosh; Honarmand, Azim

    2010-01-01

    Disturbances in the plasma sodium level in patients with severe brain injury (SBI) is not a rare phenomenon and may cause adverse effects on prognosis and treatment outcomes. The knowledge of the prevalence of risk factors helps in early detection and good management of the serum sodium level disturbance. Materials and methods: This is a prospective clinical trial double blind study. The target population included patients with SBI who had disturbances in their plasma sodium level and were a...

  12. 妊娠期糖尿病母儿不良妊娠结局的危险因素分析%ANALYSIS OF RISK FACTORS FOR ADVERSE MATERNAL AND FETAL OUTCOMES IN PREGNANT WOMEN WITH GESTATIONAL DIABETES MELLITUS

    Institute of Scientific and Technical Information of China (English)

    胡矩锋

    2015-01-01

    Objective To investigate the influencing factors for adverse maternal and neonatal outcomes in women with gestational diabetes mellitus (GDM) .Methods The pregnant women diagnosed with GDM and with complete clinical data were chosen for study from January ,2014 to December ,2014 .59 of them in the observation group received strict dietary and exercise management ,snd 52 cases who disregard the doctor's orders ,food control or exercise formed the contrast group .The maternal and neonatal outcomes of these 2 groups were compared .The effect of age ,BMI before pregnancy ,excessive weight gain during pregnancy ,the way to control blood sugar ,the history of abnormal gestation and birth ,the family history of diabetes , w hether or not taking insulin and gestational age on maternal and neonatal outcomes were also analyzed . Results T he usage of insulin in the ob‐servation group were lower than that in the control group ( P <0 .05) ,and the gestational weight gain in the observation group was less than that in the control group ( P<0 .05) .The occurrence of hypertensive disorder in the observation group were significantly lower than that in the control group ( P <0 .05) ,and the total occurrence of adverse maternal and neonatal outcomes in the observation group were significantly lower than that in the control group ( P <0 .05) .Excessive weight gain during pregnancy ,the history of abnormal gestation and birth ,high BMI before pregnancy and te use of insulin were risk factors for adverse neonatal outcomes ,while enough gestational age was the protective factor for both maternal and neonatal outcomes( P <0 .05) .Conclusion For patients with GDM ,there are risk factors influencing maternal and fetal adverse outcomes ,and it is useful to conduct health education and to standardize the clinical manage‐ment .%目的:探讨影响妊娠期糖尿病(GDM )患者母儿不良妊娠结局的相关因素。方法自2014年1月至2014年12月间在临沂市妇幼保健

  13. Radiologic assessment of resectability and prognosis in esophageal carcinoma

    International Nuclear Information System (INIS)

    Utilizing double-contrast technique it is possible to detect the earliest malignant lesions of the esophagus even when the carcinoma is confined to the mucosa. In patients with carcinoma, it is also important to attempt to grade and classify the lesion in order to predict its resectability and prognosis. The resectability of a lesion is determined by the depth of invasion and by the presence or absence of lymph node metastases. The significant factors are the length of the lesion, its gross morphology, the character of its margins, and the depth of ulceration. Unfortunately, the depth of invasion is not necessarily directly related to the prognosis. In some carcinomas confined to the submucosa, lymph node metastases are already present, and these patients have a poor prognosis. The presence of lymph node metastases in early carcinoma can be suggested by the gross morphology of the lesion, its length, irregularity of the surface, and the presence of a complex lesion. Careful analysis of the radiographic features of the carcinoma can be valuable for the assessment of resectability and prognosis. (orig.) 891 AJ/orig. 892 MKO

  14. Vital prognosis after hospitalization for COPD

    DEFF Research Database (Denmark)

    Vestbo, J; Prescott, E; Lange, P;

    1998-01-01

    associated with prognosis. Survival after admission due to COPD did not change significantly over time. CONCLUSION: Compared to previous studies of COPD patients, the present study indicates that prognosis after hospital admission remains virtually unchanged over the last decades. FEV1 is still the strongest...

  15. Prognosis for conservative therapy to vertebral compression fractures

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate the poor prognosis factor in patients with vertebral compression fractures. We radiologically investigated the degree of vertebral collapse and kyphotic curves in 43 patients. Patients complaining of back pain were found to have significantly lower vertebral height and progressive kyphotic deformity. Early MRI findings suggested that the existence of posterior vertebral damage was correlated with vertebral collapse, kyphotic deformity, and continuous back pain. (author)

  16. Diagnosis and prognosis of acute hamstring injuries in athletes

    OpenAIRE

    Kerkhoffs, Gino M. M. J.; van Es, Nick; Wieldraaijer, Thijs; Sierevelt, Inger N.; Ekstrand, Jan; van Dijk, C. Niek

    2012-01-01

    Purpose Identification of the most relevant diagnostic and prognostic factors of physical examination and imaging of hamstring injuries in (elite) athletes. Methods A literature search was conducted in MEDLINE and EMBASE for articles between 1950 and April 2011. A survey was distributed among the members of the European Society of Sports Traumatology, Knee Surgery and Arthroscopy, which focused on physical examination, prognosis, imaging and laboratory tests of hamstring injuries in (elite) a...

  17. Temporal trends in the incidence and prognosis of aortic stenosis

    DEFF Research Database (Denmark)

    Martinsson, Andreas; Li, Xinjun; Andersson, Charlotte;

    2015-01-01

    BACKGROUND: The aging of Western populations is expected to result in increasing occurrence of aortic stenosis (AS), but data are limited. Recent studies have reported declining incidence and mortality for other major heart diseases. We aimed to study temporal trends in the incidence and prognosis...... could suggest that improved risk factor control and cardiovascular therapy, combined with increased use of aortic valve replacement in the elderly and reduced perioperative mortality in aortic valve replacement, have translated into favorable effects for AS....

  18. 胰岛素样生长因子结合蛋白-1在急性心肌梗死预后中的研究进展%Advances in Insulin-like Growth Factor Binding Protein-1 in the Prognosis of Acute Myocardial Infarction

    Institute of Scientific and Technical Information of China (English)

    陆慧; 潘慧; 龚凤英

    2011-01-01

    胰岛素样生长因子(IGF)系统与心血管疾病存在密切关联,其中血清低水平IGF-I和高水平胰岛素样生长因子结合蛋白-1 (IGFBP-1)可以作为判断AMI患者远期心血管发病率和死亡率的预后指标.本文总结了IGFBP-1在AMI预后判断方面的研究进展.%Insulin-like growth factor (IGF) is closely associated with cardiovascular diseases. Low IGF-I level and high insulin-like growth factor binding protein-1 (IGFBP-1) level in serum can be used as a marker in predicting the long-term morbidity and mortality of acute myocardial infarction (AMI). The article reviews the recent advances in IGFBP-1 in the prognosis of AMI.

  19. Developmental dyscalculia: prevalence and prognosis.

    Science.gov (United States)

    Shalev, R S; Auerbach, J; Manor, O; Gross-Tsur, V

    2000-01-01

    The prevalence of developmental dyscalculia (DC) in the school population ranges from 3-6 %, a frequency similar to that of developmental dyslexia and ADHD. These studies fulfilled the criteria for an adequate prevalence study, i.e., were population based, using standardized measures to evaluate arithmetic function. Although the variation in prevalence is within a narrow range, the differences are probably due to which definition of dyscalculia was used, the age the diagnosis was made and the instrument chosen to test for DC. The relative predominance of girls with DC may reflect a greater vulnerability to environmental influences alone or in addition to a biological predisposition. DC is not only encountered as a specific learning disability but also in diverse neurological disorders, examples of which include ADHD, developmental language disorder, epilepsy, treated phenylketonuria and Fragile X syndrome. Although the long-term prognosis of DC is as yet unknown, current data indicate that DC is a stable learning disability persisting, at least for the short term, in about half of affected children. The long-term consequences of DC and its impact on education, employment and psychological well-being have yet to be determined. PMID:11138905

  20. Syncope: epidemiology, etiology and prognosis.

    Directory of Open Access Journals (Sweden)

    Rose M F Lisboa Da Silva

    2014-12-01

    Full Text Available Syncope is a common medical problem, with a frequency between 15% and 39%. In the general population, the annual number episodes are 18.1 to 39.7 per 1000 patients, with similar incidence between genders. The first report of the incidence of syncope is 6.2 per 1000 person-years. However, there is a significant increase in the incidence of syncope after 70 years of age with rate annual 19.5 per thousand individuals after 80 years. It presents a recurrence rate of 35% and 29% of physical injury. Among the causes of syncope, the mediated neural reflex, known as neurocardiogenic or vasovagal syncope, is the most frequent. The others are of cardiac origin, orthostatic hypotension, carotid sinus hypersensitivity, neurological and endocrinological causes and psychiatric disorders. The diagnosis of syncope can be made by clinical method associated with the electrocardiogram in up 50% of patients. Its prognosis is determined by the underlying etiology specifically the presence and severity of cardiac disease. The annual mortality can reach between 18 and 33% if cardiac cause, and between 0 and 12% if the noncardiac cause. Thus, it is imperative to identify its cause and risk stratification for positive impact in reducing morbidity and mortality.

  1. 血清表皮生长因子、肝细胞生长因子与急性胰腺炎严重程度及预后的相关性%The correlation between serum epidermal growth factor, hepatocyte growth factor, and severity or prognosis of acute pancreatitis

    Institute of Scientific and Technical Information of China (English)

    李志娟

    2014-01-01

    目的 探讨血清表皮生长因子、肝细胞生长因子与急性胰腺炎严重程度及预后的相关性,为临床诊治提供依据.方法 选择急性胰腺炎(AP)患者112例,按严重程度分为轻症急性胰腺炎(MAP)组(n=66)和重症急性胰腺炎(SAP)组(n=46),两组患者均采用常规治疗,观察两组患者血清表皮生长因子(EGF)、肝细胞生长因子(HGF)水平,并与急性生理和慢性健康状况评分表Ⅱ(APACHEⅡ)评分进行相关性分析,比较两组患者的并发症情况.结果 MAP组、SAP组血清EGF、HGF水平均明显高于对照组,SAP组明显高于MAP组(P <0.01). MAP组、SAP组APACHE Ⅱ评分分别为(5.4±1.6)分、(9.0±2.9)分,APACHE Ⅱ评分与血清EGF、HGF水平呈正相关(P=0.00).SAP组的(感染、脓肿、坏死)、急性肺损伤或ARDS发生率明显高于MAP组(P<0.01).结论 AP的严重程度及预后与患者血清HGF、EGF水平关系密切,在早期及时监测HGF、EGF的变化对评估病情及判断预后有一定的临床价值,由于HGF、EGF具有较强的组织修复与再生功能,这也可能为临床治疗提供一个新途径.%Objective To investigate the correlation between serum epidermal growth factor,hepatocyte growth factor and acute pancreatitis severity or prognosis,and to provide the basis for acute pancreatitis clinical diagnosis and treatment.Methods A total of 112 patients with acute pancreatitis (AP) were selected,and they were divided into mild acute pancreatitis (MAP) group (n =66) and severe acute pancreatitis (SAP) group (n =46) according to severity.The patients in two groups were treated with conventional therapy.The levels of serum epidermal growth factor (EGF) and hepatocyte growth factor (HGF) in two groups were observed.The correlation analysis was performed with acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) score.The complications of patients in two groups were compared.Results The levels of serum EGF and HGF in MAP group and SAP

  2. From hopeless to good prognosis: journey of a failing tooth.

    Science.gov (United States)

    Gupta, Saurabh; Deshmukh, Jeevanand; Khatri, Richa; Kulkarni, Vinaya Kumar; Karthik, B

    2015-02-01

    Chronic periodontitis, along with associated clinical findings such as pathologic tooth migration, diastema, functional and aesthetic aberrations, poses an immense challenge to a dental professional. These findings convert clinical decision making into a daunting task and adversely affect the prognosis and the treatment plan for the presenting clinical problem. An interdisciplinary approach aimed at restoring functional and aesthetic needs of the affected individual within the limitations of such a compromised clinical scenario may be a viable alternative to any radical treatment causing loss of natural tooth structure such as extraction. This article reports the usefulness of the interdisciplinary route for managing an otherwise hopeless clinical situation of chronic periodontitis complicated with extreme mobility and pathologic tooth migration, which resulted in compromised function and aesthetics. PMID:25859109

  3. A scoring model for predicting the prognosis of severe viral hepatitis

    Institute of Scientific and Technical Information of China (English)

    DING Hui-guo; XIANG Hai-ping; SHAN Jing; ZHOU Li; MA Bing; LIU Min; WANG Jun-tao

    2005-01-01

    @@ The prognosis of patients with severe viral hepatitis is concerned by clinicians, patients and their relatives. Many factors may influence on the prognosis of patients with this disease. Many studies on the prognosis of severe viral hepatitis by multiple logistic regression analysis have shown generally consistent results.1-4 Previouly we established a scoring model of severe viral hepatitis (SMSVH) by logistic regression analysis.1 The aim of this study was to estimate prospectively the 6-month survival rate of patients with severe viral hepatitis using SMSVH.

  4. Liver Cirrhosis: Evaluation, Nutritional Status, and Prognosis.

    Science.gov (United States)

    Nishikawa, Hiroki; Osaki, Yukio

    2015-01-01

    The liver is the major organ for the metabolism of three major nutrients: protein, fat, and carbohydrate. Chronic hepatitis C virus infection is the major cause of chronic liver disease. Liver cirrhosis (LC) results from different mechanisms of liver injury that lead to necroinflammation and fibrosis. LC has been seen to be not a single disease entity but one that can be graded into distinct clinical stages related to clinical outcome. Several noninvasive methods have been developed for assessing liver fibrosis and these methods have been used for predicting prognosis in patients with LC. On the other hand, subjects with LC often have protein-energy malnutrition (PEM) and poor physical activity. These conditions often result in sarcopenia, which is the loss of skeletal muscle volume and increased muscle weakness. Recent studies have demonstrated that PEM and sarcopenia are predictive factors for poorer survival in patients with LC. Based on these backgrounds, several methods for evaluating nutritional status in patients with chronic liver disease have been developed and they have been preferably used in the clinical field practice. In this review, we will summarize the current knowledge in the field of LC from the viewpoints of diagnostic method, nutritional status, and clinical outcomes. PMID:26494949

  5. A correlative study of serum levels of vascular endothelial growth factor and prognosis and platelet in patients with lung cancer%肺癌患者血清血管内皮生长因子水平与预后及血小板的相关性研究

    Institute of Scientific and Technical Information of China (English)

    黄谦; 姜正华; 朱慕云; 桑慧颖; 卞京文; 李昌喜

    2011-01-01

    目的 探讨肺癌患者血清血管内皮生长因子(VEGF)水平及与预后及血小板的相关性.方法 采用酶联免疫吸附法(ELISA)对60例肺癌患者及20例健康人的血清VEGF分别进行测定,同时检测患者全血血小板(PLT)含量.结果 肺癌患者血清VEGF水平显著高于健康对照组(P<0.01),肺癌患者血清VEGF水平与肺癌的病理类型、TNM分期之间无明显关系.肺癌患者血清VEGF水平与其生存期之间呈显著的负相关(r=-0.38.P<0.01),肺癌患者血清VEGF水平与血小板之间呈显著的正相关(r=0.26,P<0.05).结论 肺癌患者血清VEGF水平与患者的预后密切相关,血清VEGF是评估肺癌患者预后的重要指标.肺癌患者血清VEGF水平与PLT水平密切相关,血小板在肿瘤血管形成的过程中可能起重要的作用.%Objective To investigate the serum levels of vascular endothelial growth factor in patients with lung cancer and to explore the relationship between the serum levels of vascular endothelial growth factor on prognosis and platelet. Methods The serum levels of vascular endothelial growth factor were measured in sixty patients with lung cancer and twenty normal controls by enzyme -linked immunosorbent assay, the platelet counts were measured. Results The serum levels of vascular endothelial growth factor in patients with lung cancer were significantly higher than those in normal controis. The serum levels of vascular endothelial growth factor in patients with lung cancer were not related to histological classification, P- TNM. There was negative correlation between the serum levels of vascular endothelial growth factor in patients with lung cancer and survival( r = -0.38, P < 0.01 ),the serum levels of vascular endothelial growth factor positively correlated to platelet counts( r =0.26,P <0.05). Conclusion There was significantly correlation between the serum levels of vascular endothelial growth factor in patients with lung cancer and prognosis, the

  6. Cancer Patients, Doctors Often Disagree about Prognosis

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_159903.html Cancer Patients, Doctors Often Disagree About Prognosis Those with advanced disease are likely to be more optimistic than their doctor, study shows To use the sharing features on ...

  7. Comparative analysis on the influence factors of short-term and long-term prognosis in patients with HBV-related acute-on-chronic liver failure%乙型肝炎相关慢加急性肝衰竭早期及远期预后的影响因素比较分析

    Institute of Scientific and Technical Information of China (English)

    夏向群; 蒋素文; 胡爱荣; 胡耀仁; 胡婷; 金珊珊; 邓勤智

    2016-01-01

    目的 对比分析乙型肝炎相关慢加急性肝衰竭(ACLF)早期(6个月)及远期(10年)预后的影响因素,为指导临床治疗及随访管理提供参考价值.方法 选取2001年1月至2009年12月住院的524例ACLF患者的临床资料,随访终止时间为2013年12月;所有患者均给予内科综合治疗,并依据患者的知情选择给予或不给予核苷/核苷酸类药物(NAs)和人工肝治疗,对可能影响其预后的因素进行Cox回归分析.结果 ACLF患者近期预后的影响因素大小依次为终末期肝病模型评分、患者年龄、中性粒细胞比率、合并肝性脑病、NAs抗病毒治疗与否、HBV DNA水平、人工肝血浆置换治疗次数、胆碱酯酶和总胆红素(P<0.05);远期预后的影响因素大小依次为患者年龄、NAs应用与否、MELD评分、胆碱酯酶、伴随感染、白细胞计数、患者性别和肝性脑病(P<0.05),其中NAs抗病毒治疗是一个时间依赖性的独立预后因素.结论 ACLF早期及远期预后的影响因素有所差异,患者的早期治疗及远期随访管理均需要持续NAs抗病毒治疗、改善肝脏功能、防治感染和肝性脑病等并发症,早期治疗还需要积极给予人工肝治疗.%Objective To comparative analyze the influence factors of short-term (6 months) and long-term (10 years) prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF),and to provide some reference values on clinic therapy and follow-up management.Methods The data of 524 hospitalized patients with ACLF from January 2001 to December 2009 were analyzed retrospectively.The follow-up termination time was December 2013.Patients were all given internal medical therapy,and were given antiviral therapy with nucleoside and nucleotide analogs (NAs) (yes/no) and plasma exchange in artificial liver support system (yes/no) according to the patient's informed choice.The method of Cox regression analysis was used to analyze the short-term prognostic

  8. Aortic Arch Atherosclerosis in Ischaemic Stroke of Unknown Origin Affects Prognosis

    OpenAIRE

    Abe, Arata; Harada-Abe, Mina; Ueda, Masayuki; Katano, Takehiro; Nakajima, Masataka; Muraga, Kanako; Suda, Satoshi; Nishiyama, Yasuhiro; Okubo, Seiji; Mishina, Masahiro; Katsura, Ken-ichiro; Katayama, Yasuo

    2014-01-01

    Background Cerebral infarction of unknown origin at admission accounts for half of all cerebral infarction cases in some institutions. However, the factors associated with cerebral infarction prognosis have not been sufficiently examined. Here, we investigated whether aortic arch plaques (AAPs) on transoesophageal echocardiography (TOE) were associated with the prognosis of cerebral infarction of unknown origin at admission. Methods Of 571 patients who were hospitalised between June 2009 and ...

  9. Poorer Prognosis With Ethylenediaminetetraacetic Acid-dependent Pseudothrombocytopenia: A Single-center Case-control Study.

    OpenAIRE

    Ohashi-Fukuda, N; Inokuchi, R; Sato, H.; Nakamura, K.; Iwagami, M; Wada, T.; Jona, M; Hisasue, T; Nakajima, S.; Yahagi, N

    2015-01-01

    Abstract In ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP), automated platelet counts are lower than actual counts because of EDTA-induced aggregation. Factors contributing to the incidence of EDTA-PTCP are unknown, and no study has assessed the prognosis of EDTA-PTCP patients. This retrospective study assessed characteristics in EDTA-PTCP patients and matched controls to determine differences in prognosis. A retrospective case–control study was designed. From ...

  10. Long term prognosis of reactive salmonella arthritis

    OpenAIRE

    Leirisalo-Repo, M; Helenius, P; Hannu, T; Lehtinen, A; Kreula, J; Taavitsainen, M; Koskimies, S

    1997-01-01

    OBJECTIVES—Reactive joint complications triggered by salmonella gastroenteritis are increasingly reported, but the outcome and long term prognosis of the patients is incompletely known. This study looked at the prognosis of salmonella arthritis in patients hospitalised in 1970-1986.
METHODS—Hospital records from two hospitals in southern Finland were screened for patients with the discharge diagnosis of salmonellosis or reactive, postinfectious arthritis or Reiter's disease. For the patients ...

  11. Machinery prognostics and prognosis oriented maintenance management

    CERN Document Server

    Yan, Jihong

    2014-01-01

    This book gives a complete presentatin of the basic essentials of machinery prognostics and prognosis oriented maintenance management, and takes a look at the cutting-edge discipline of intelligent failure prognosis technologies for condition-based maintenance.  Latest research results and application methods are introduced for signal processing, reliability moelling, deterioration evaluation, residual life prediction and maintenance-optimization as well as applications of these methods.

  12. 急性重症胰腺炎患者血脂水平变化及预后不良的危险因素分析%Changes in Serum Lipid Levels and Risk Factors for Poor Prognosis in Patients with Severe Acute Pancreatitis

    Institute of Scientific and Technical Information of China (English)

    游红勇; 陈智敏; 白燕; 杜成友; 陈开全

    2014-01-01

    Objective To investigate the changes in serum lipid levels and the risk factors for poor prognosis in patients with severe acute pancreatitis .Methods A retrospective analysis was conducted in 100 patients with acute severe pancreatitis ( survival 87 cases and 13 cases died ) , the serum lipid level on the first day after admission was tested .The clinical data of survival group and death group were analyzed to explore the risk factors for poor prognosis in patients with acute severe pancreatitis .Results There was no significant difference in gender and CT score between two groups(P>0.05).The age,APACHEⅡ score,Ranson score and duration in the survival group were significantly smaller or less than those in the death group (P0.05).Unconditional logistic regression analysis showed that age ,high TG levels,high APACHEⅡscore were independent risk factors for severe acute pancreatitis patients with poor prognosis (P<0.05).Conclusion Age,high TG levels,high APACHE Ⅱ score are independent risk factor for severe acute pancreatitis patients with poor prognosis .%目的:探讨急性重症胰腺炎患者血脂水平变化及预后不良的危险因素。方法对100例急性重症胰腺炎患者(存活87例,死亡13例)的临床资料进行回顾性分析,测定患者入院后第1天血脂水平。对比分析存活组和死亡组的临床资料,探讨急性重症胰腺炎患者预后不良的危险因素。结果两组性别、CT评分比较,差异无统计学意义( P>0.05)。存活组年龄、APACHEⅡ评分、Ranson评分、病程均明显小于或低于死亡组( P<0.05)。存活组入院后次日TC、TG均明显低于死亡组( P<0.05),而HDL、LDL 差异无统计学意义( P>0.05)。非条件logistic回归分析结果显示,年龄大、TG水平高、APACHEⅡ评分高是急性重症胰腺炎患者预后不良的独立危险因素( P<0.05)。结论年龄大、TG水平高、APACHEⅡ评分高是急性重症

  13. Adverse Event Reporting System (AERS)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Adverse Event Reporting System (AERS) is a computerized information database designed to support the FDA's post-marketing safety surveillance program for all...

  14. Predictive value of equilibrium radionuclide ventriculography for long term prognosis of acute myocardial infarction

    International Nuclear Information System (INIS)

    The predictive value of equilibrium radionuclide ventriculography (ERNV) for the long term prognosis of acute myocardial infarction (AMI) was studied. 89 patients with AMI examined by ERNV 4∼6 weeks after onset of AMI were studied and followed up for 23(12∼42) months. According to patients' prognosis, two groups were divided. Group 1 was patients with sudden cardiac death (SCD) or heart failure (HF) (n = 20). Group 2, patients without any cardiac events (n = 69). These patients were paired with the age and sex (ratio: 1:2). 17 factors which may affect the long-term prognosis of AMI were analyzed. results showed: 1. The incidence of SCD was 2.2%. 2. Excluding the age and sex factor, the lateral wall ejection fraction of left ventricle (LAT-EF) and the level of serum CK-MB were two independent main effective risk factors of the long-term prognosis of AMI. 3. Prognosis index formula: Z = 2.467 (LAT-EF) + 0.760(CK-MB) was established. The larger the value of Z, the higher the incidence of SCD or HF. ERNV played an important role on predicting long term prognosis of patients with AMI

  15. Reverse Engineering Adverse Outcome Pathways

    Energy Technology Data Exchange (ETDEWEB)

    Perkins, Edward; Chipman, J.K.; Edwards, Stephen; Habib, Tanwir; Falciani, Francesco; Taylor, Ronald C.; Van Aggelen, Graham; Vulpe, Chris; Antczak, Philipp; Loguinov, Alexandre

    2011-01-30

    The toxicological effects of many stressors are mediated through unknown, or poorly characterized, mechanisms of action. We describe the application of reverse engineering complex interaction networks from high dimensional omics data (gene, protein, metabolic, signaling) to characterize adverse outcome pathways (AOPs) for chemicals that disrupt the hypothalamus-pituitary-gonadal endocrine axis in fathead minnows. Gene expression changes in fathead minnow ovaries in response to 7 different chemicals, over different times, doses, and in vivo versus in vitro conditions were captured in a large data set of 868 arrays. We examined potential AOPs of the antiandrogen flutamide using two mutual information theory methods, ARACNE and CLR to infer gene regulatory networks and potential adverse outcome pathways. Representative networks from these studies were used to predict a network path from stressor to adverse outcome as a candidate AOP. The relationship of individual chemicals to an adverse outcome can be determined by following perturbations through the network in response to chemical treatment leading to the nodes associated with the adverse outcome. Identification of candidate pathways allows for formation of testable hypotheses about key biologic processes, biomarkers or alternative endpoints, which could be used to monitor an adverse outcome pathway. Finally, we identify the unique challenges facing the application of this approach in ecotoxicology, and attempt to provide a road map for the utilization of these tools. Key Words: mechanism of action, toxicology, microarray, network inference

  16. Radiation Therapy Overcomes Adverse Prognostic Role of Cyclooxygenase-2 Expression on Reed-Sternberg Cells in Early Hodgkin Lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Mestre, Francisco [Service of Radiation Therapy, University Hospital Son Espases, Instituto de Investigación Sanitaria de Palma, Palma de Mallorca (Spain); Gutiérrez, Antonio, E-mail: antoniom.gutierrez@ssib.es [Service of Hematology, University Hospital Son Espases, Instituto de Investigación Sanitaria de Palma, Palma de Mallorca (Spain); Rodriguez, Jose [MD Anderson Cancer Center, Madrid (Spain); Ramos, Rafael [Service of Pathology, University Hospital Son Espases, Instituto de Investigación Sanitaria de Palma, Palma de Mallorca (Spain); Garcia, Juan Fernando [Spanish National Cancer Research Centre, Madrid (Spain); Martinez-Serra, Jordi [Service of Hematology, University Hospital Son Espases, Instituto de Investigación Sanitaria de Palma, Palma de Mallorca (Spain); Casasus, Marta; Nicolau, Cristina [Service of Radiation Therapy, Policlinica Miramar, Palma de Mallorca (Spain); Bento, Leyre; Herraez, Ines [Service of Hematology, University Hospital Son Espases, Instituto de Investigación Sanitaria de Palma, Palma de Mallorca (Spain); Lopez-Perezagua, Paloma [Service of Radiology, IDISPA, Palma de Mallorca (Spain); Daumal, Jaime [Service of Nuclear Medicine, IDISPA, Palma de Mallorca (Spain); Besalduch, Joan [Service of Hematology, University Hospital Son Espases, Instituto de Investigación Sanitaria de Palma, Palma de Mallorca (Spain)

    2015-05-01

    Purpose: To analyze the role of radiation therapy (RT) on the adverse prognostic influence of cyclooxygenase-2 (COX-2) expression on Reed-Sternberg (RS) cells, in the setting of early Hodgkin lymphoma (HL) treated with ABVD (adriamycin, vinblastine, bleomycin, dacarbazine). Methods and Materials: In the present study we retrospectively investigated the prognostic value of COX-2 expression in a large (n=143), uniformly treated early HL population from the Spanish Network of HL using tissue microarrays. Univariate and multivariate analyses were done, including the most recognized clinical variables and the potential role of administration of adjuvant RT. Results: Median age was 31 years; the expression of COX-2 defined a subgroup with significantly worse prognosis. Considering COX-2{sup +} patients, those who received RT had significantly better 5-year progression-free survival (PFS) (80% vs 54% if no RT; P=.008). In contrast, COX-2{sup −} patients only had a modest, nonsignificant benefit from RT in terms of 5-year PFS (90% vs 79%; P=.13). When we compared the outcome of patients receiving RT considering the expression of COX-2 on RS cells, we found a nonsignificant 10% difference in terms of PFS between COX-2{sup +} and COX-2{sup −} patients (P=.09), whereas the difference between the 2 groups was important (25%) in patients not receiving RT (P=.04). Conclusions: Cyclooxygenase-2 RS cell expression is an adverse independent prognostic factor in early HL. Radiation therapy overcomes the worse prognosis associated with COX-2 expression on RS cells, acting in a chemotherapy-independent way. Cyclooxygenase-2 RS cell expression may be useful for determining patient candidates with early HL to receive consolidation with RT.

  17. Radiation Therapy Overcomes Adverse Prognostic Role of Cyclooxygenase-2 Expression on Reed-Sternberg Cells in Early Hodgkin Lymphoma

    International Nuclear Information System (INIS)

    Purpose: To analyze the role of radiation therapy (RT) on the adverse prognostic influence of cyclooxygenase-2 (COX-2) expression on Reed-Sternberg (RS) cells, in the setting of early Hodgkin lymphoma (HL) treated with ABVD (adriamycin, vinblastine, bleomycin, dacarbazine). Methods and Materials: In the present study we retrospectively investigated the prognostic value of COX-2 expression in a large (n=143), uniformly treated early HL population from the Spanish Network of HL using tissue microarrays. Univariate and multivariate analyses were done, including the most recognized clinical variables and the potential role of administration of adjuvant RT. Results: Median age was 31 years; the expression of COX-2 defined a subgroup with significantly worse prognosis. Considering COX-2+ patients, those who received RT had significantly better 5-year progression-free survival (PFS) (80% vs 54% if no RT; P=.008). In contrast, COX-2− patients only had a modest, nonsignificant benefit from RT in terms of 5-year PFS (90% vs 79%; P=.13). When we compared the outcome of patients receiving RT considering the expression of COX-2 on RS cells, we found a nonsignificant 10% difference in terms of PFS between COX-2+ and COX-2− patients (P=.09), whereas the difference between the 2 groups was important (25%) in patients not receiving RT (P=.04). Conclusions: Cyclooxygenase-2 RS cell expression is an adverse independent prognostic factor in early HL. Radiation therapy overcomes the worse prognosis associated with COX-2 expression on RS cells, acting in a chemotherapy-independent way. Cyclooxygenase-2 RS cell expression may be useful for determining patient candidates with early HL to receive consolidation with RT

  18. Eventos adversos pós-vacina contra a difteria, coqueluche e tétano e fatores associados à sua gravidade Adverse events following diphtheria, pertussis and tetanus vaccinations and factors associated with severity

    Directory of Open Access Journals (Sweden)

    Fabiana Ramos Martin de Freitas

    2007-12-01

    Full Text Available OBJETIVO: Avaliar os eventos adversos pós-vacina contra a difteria, coqueluche e tétano (EAPV-DPT e os fatores associados à sua gravidade. MÉTODOS: Estudo transversal com componente descritivo e analítico, abrangendo os eventos adversos pós-vacina DPT notificados no Estado de São Paulo, de 1984 a 2001, entre crianças menores de sete anos de idade. A definição de caso foi a adotada pela vigilância de EAPV-DPT; os dados obtidos foram originados da vigilância passiva desses eventos. No cálculo das taxas, o numerador foram os EAPV e o denominador o número de doses aplicadas. A associação entre a gravidade dos EAPV-DPT e as exposições de interesse foi investigada pelas estimativas não ajustadas e ajustadas da odds ratio, com os respectivos intervalos de 95% de confiança, usando regressão logística não condicional. RESULTADOS: Identificaram-se 10.059 EAPV-DPT relativos a 6.266 crianças, apresentando um ou mais EAPV, 29,5% foram internadas e em 68,2% houve contra-indicação das doses subseqüentes de DPT. Cerca de 75% dos eventos ocorreram nas primeiras seis horas após a aplicação da vacina. Os eventos mais freqüentes foram: febreOBJECTIVE: To analyze adverse events following vaccinations against diphtheria, pertussis and tetanus (AEFV-DPT and to investigate factors associated with event severity. METHODS: A cross-sectional study was carried out with a descriptive and analytical component covering AEFV-DPT that were notified in the State of São Paulo, Brazil, between 1984 and 2001, among children less than seven years old. Cases were defined as used in AEFV-DPT surveillance; the data source was AEFV-DPT passive surveillance. In calculating the rates, the numerator was the number of AEFV-DPT and as denominator was the number of doses applied. The association between severity of AEFV-DPT and the exposures of interest was investigated by means of non-adjusted and adjusted estimates of odds ratios, with their respective 95

  19. Research on geological modeling and integrated prognosis technologies for uranium deposit

    International Nuclear Information System (INIS)

    Due to continuously rapid development of China's national economy, the demand on energy is increasing urgently, therefore, nuclear power become one of the necessary to the sustainable development of China's future energy. With more and more effort on uranium exploration, undiscovered uranium mineralization near surface and in subsurface is getting less, and it is more and more difficult to find U deposit directly by traditional surface survey. To meet the higher demand in the evaluation and prognosis of U resources, this paper introduces detailedly and systematically the uranium geological modeling and the prognosis technologies through integrated geological data. Guided by geodynamics, metallogenic dynamics and U metallogenetic theory, the geotectonic, geophysical, geochemical and remote sensing data of the known U deposits has been studied to summarize the prognosis factors and build geological models of U deposits. The model and prognosis factors are then transformed into evaluation and prognosis model in GIS. With GIS we can, estimate U resource amount in analogy districts in the outlined U metallogenetic prognosis zone. All the above study have resulted in an integrate set of operating method and technical flow for U resource potential evaluation. (author)

  20. Classification, staging and prognosis of lung cancer

    International Nuclear Information System (INIS)

    Lung cancer has increased in incidence throughout the twentieth century and is now the most common cancer in the Western World. It has a poor prognosis, only 10-15% of patients survive 5 years or longer. Outcome is dependent on clinical stage and cancer cell type. Lung cancer is broadly subclassified on the basis of histological features into squamous cell carcinoma, adenocarcinoma, large cell carcinoma and small cell carcinoma. The histopathological type of lung cancer correlates with tumour behaviour and prognosis. Staging based on prognosis is essential in clinical trials comparing different management strategies, and enables universal communication regarding the efficacy of different treatments in specific patient groups. The anatomic extent of disease determined either preoperatively using imaging supplemented by invasive procedures such as mediastinoscopy, and anterior mediastinotomy or following resection are described according to the T-primary tumour, N-regional lymph nodes, M-distant metastasis classification. The International System for Staging Lung Cancer attempts to group together patients with similar prognosis and treatment options. Various combinations of T, N, and M define different clinical or surgical-pathological stages (IA-IV) characterised by different survival characteristics. Refinements in staging based on imaging findings have enabled clinical staging to more accurately reflect the surgical-pathological stage and therefore more accurately predict prognosis. Recent advances including the use of positron emission tomography in combination with conventional staging promises to increase the accuracy of staging and therefore to reduce the number of invasive staging procedures and inappropriate thoracotomies

  1. The risk factors of prognosis in the children patients with acute gastrointestinal dysfunction and ;prevention measures%影响并发急性胃肠功能障碍患儿预后的危险因素及防治措施

    Institute of Scientific and Technical Information of China (English)

    蒋宏; 封东进; 朱峰; 曹军华; 杨秋丽

    2016-01-01

    目的:分析影响并发急性胃肠功能障碍患儿预后的危险因素,并探讨防治措施。方法回顾性分析125例并发急性胃肠功能障碍患儿的临床资料,采用多因素非条件Logistic回归分析对可能影响患儿预后的危险因素进行分析。结果125例并发急性胃肠功能障碍患儿中,死亡61例,病死率为48.8%。多因素非条件Logistic回归分析显示,循环不良/休克、肝衰竭、脑衰竭为影响并发急性胃肠功能障碍患儿预后的独立危险因素(OR=4.156、3.330、6.903,P<0.05或<0.01)。结论循环不良/休克、肝衰竭、脑衰竭是并发急性胃肠功能障碍患儿死亡的危险因素。%Objective To study the risk factors influencing the prognosis in the children patients with acute gastrointestinal dysfunction and to seek their therapeutic measures. Methods The clinical data of 125 cases patients with acute gastrointestinal dysfunction were retrospectively analyzed. The risk factors possibly influencing the prognosis were analyzed by multivariate statistical Logistic analysis. Results Among 125 children patients, 61 cases died, and the mortality rate was 48.8%. Logistic regression analysis indicated that poor circulation, cardiovascular system failure, hepatic failure, brain failure were significant risk factors of death associated with acute gastrointestinal dysfunction. (OR = 4.156, 3.330, 6.903, P<0.05 or<0.01). Conclusions Poor circulation, cardiovascular system failure, hepatic failure and brain failure are significant risk factors of death associated with acute gastrointestinal dysfunction.

  2. Fulda thyroid nodule prognosis program

    International Nuclear Information System (INIS)

    The 'Fulda'-program calculates for thyroid nodule patients the probability of management with respect to surgery, follow up, radioiodine therapy or fine needle aspiration biopsy by use of the weighted factors: pre-existing results, patient age, palpation, thyroid volume, marginal nodule perfusion, echo texture, thyroid volume increase and TSH level. As the following definite management is in good correlation to the precalculated management, the 'Fulda'-program could be useful for organisation and strategy of thyroid nodule patients. (orig.)

  3. Assessing risk factors for adverse birth outcomes and early childhood respiratory illness: an examination of supplement initiation and participation in Special Supplemental Nutrition Program for Women, Infants and Children during pregnancy

    OpenAIRE

    Alfonso, Vivian

    2015-01-01

    In the United States, rate of preterm birth peaked in 2006 and little progress has been made to date despite ambitious Healthy People 2020 goals. Infants born premature are at higher risk of death and disability, including psychological conditions, learning difficulties and medical disabilities, than term newborns. Additionally, adverse birth outcomes are associated with asthma, the leading cause of chronic childhood illness and disability. According to the ‘Barker hypothesis’, intrauterin...

  4. Tetany: Possible adverse effect of bevacizumab

    Directory of Open Access Journals (Sweden)

    S R Anwikar

    2011-01-01

    Full Text Available Background: Bevacizumab a recombinant humanized monoclonal antibody was approved in 2004 by US FDA for metastatic colorectal cancer. It is reported to cause potentially serious toxicities including severe hypertension, proteinuria, and congestive heart failure. Aim: To correlate adverse event tetany with the use of bevacizumab. Materials and Methods : World Health Organization′s Uppsala Monitoring Centre, Sweden, for reporting of adverse drug reactions from all over the world, identified 7 cases with tetany-related symptoms to bevacizumab from four different countries. These 7 patients reported to UMC database developed adverse events described as musculoskeletal stiffness (1, muscle spasm (1, muscle cramps (1, lock jaw or jaw stiffness (4, and hypertonia (1, with hypocalcaemia. Results: After detailed study of the possible mechanism of actions of bevacizumab and factors causing tetany, it is proposed that there is a possibility of tetany by bevacizumab, which may occur by interfering with calcium metabolism. Resorption of bone through osteoclasts by affecting VEGF may interfere with calcium metabolism. Another possibility of tetany may be due to associated hypomagnesaemia, hypokalemia, or hyponatremia. Conclusions: Tetany should be considered as a one of the signs. Patient on bevacizumab should carefully watch for tetany-related symptoms and calcium and magnesium levels for their safety.

  5. Effect of Early Intensive Insulin Therapy on Inflammatory Factors and Prognosis of Severe Acute Pancreatitis Patients%早期胰岛素强化治疗对急性重症胰腺炎患者炎症因子及预后的影响

    Institute of Scientific and Technical Information of China (English)

    黎辉

    2015-01-01

    Objective :To explore the effect of early intensive insulin therapy on inflammatory factors and prognosis of severe acute pancreatitis patients .Methods :Selected 68 cases of severe acute pancreatitis patients in our hospital from June 2012 to September 2014 for sampling ,were randomly divided into two groups ,the control group received routine treatment ,the experimental group implementation of early intensive insulin therapy ,compared serum levels of inflam‐matory mediators of two groups to improve the condition and prognosis .Results:(1) Compared to TNF‐α,CRP ,IL‐8 level :1d after treatment ,the levels of CRP and TNF‐αof experimental group were significantly lower than that of con‐trol group (P<0 .05);after treatment 3d and 7d ,the level of CRP ,IL‐8 and TNF‐αin experimental group were lower than control group (P< 0 .05);(2) prognosis :hospitalization time in experimental group was shorter than control group (P<0 .05) ,after 72h treatment APACCHE Ⅱ score was lower than control group (P<0 .05) .Conclusion:The clinical effect of early intensive insulin therapy on patients with severe acute pancreatitis is definite ,can regulate the body high inflammatory state in patients ,improve prognosis ,clinical attention should be paid .%目的:探究早期胰岛素强化治疗对急性重症胰腺炎患者炎症因子及预后的影响。方法:择取我院2012年6月-2014年9月收治的急性重症胰腺炎患者进行抽样,选取68例患者随机分成两组,对照组实施常规治疗,实验组实施早期胰岛素强化治疗,对比两组血清炎症介质水平改善情况及预后状况。结果:(1)TNF‐α、CRP、IL‐8水平比较:于治疗后1d ,实验组CRP、TNF‐α水平明显均低于对照组(P<0.05);于治疗后3、7d ,实验组CRP、IL‐8及 TNF‐α水平均低于对照组(P<0.05);(2)预后比较:实验组住院时间明显短于对照组(P<0.05),治疗72h后APACCHE

  6. 星形细胞瘤中P53、VEGF及PCNA表达的相关性及其与预后的关系%Expressions of P53, vascular endothelial growth factor and proliferating cell number antigen in astrocytomas and prognosis of these patients

    Institute of Scientific and Technical Information of China (English)

    廖志东; 朱文标; 谢寿城; 黄艳芳; 郑少秋

    2014-01-01

    目的 研究星形细胞瘤中P53、血管内皮因子(VEGF)及增殖细胞核抗原(PCNA)表达的相关性及其与预后的关系.方法 免疫组化染色SP法检测梅州市人民医院自2002年5月至2010年5月首次手术切除的126例不同级别原发性星形细胞瘤标本P53、VEGF及PCNA的表达,分析其相关性及其预后意义.结果 P53、VEGF及PCNA在不同级别的星形细胞瘤中表达不同,随着级别的提高而表达强度增加,差异有统计学意义(P<0.05);P53与PCNA、P53与VEGF之间表达呈正相关关系(r=0.608,P=0.000; r=0.432,P=0.001).相同级别星形细胞瘤中,P53阳性表达患者预后较差,生存率比较差异有统计学意义(P<0.05),VEGF及PCNA与预后无关.结论 星形细胞瘤级别提高,P53、VEGF及PCNA的表达强度增加;P53可作为判断肿瘤预后的指标之一.%Objective To study the expressions of P53,vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) in astrocytomas and their relationships with prognosis of these patients.Methods Immunohistochemical SP method was employed to detect the P53,VEGF and PCNA expression in 126 cases of human brain astrocytomas of different grades,collected in our hospital from May 2002 to May 2010; their correlations and their significance in the prognosis in these patients were analyzed.Results P53,VEGF,and PCNA expressed differently in astrocytomas of different grades,enjoying a positive relation with grades (P<0.05); positive correlations of between P53 expression and both VEGF and PCNA expressions (r=0.608,P=0.000; r=0.432,P=0.001).In patients with the same grade of astrocytoma,those having positive P53 expression enjoyed poorer prognosis and lower survival rate with significant difference (P<0.05); while VEGF and PCNA expressions had no correlation with the progonosis.Conclusion The expressions of PCNA,VEGF and P53 are closely associated with grade of the astrocytomas,and only P53 expression is an indicator of

  7. Study and evaluation of the various cutaneous adverse drug reactions in Kasturba hospital, Manipal

    Directory of Open Access Journals (Sweden)

    Ghosh S

    2006-01-01

    Full Text Available The present study emphasizes on implementation of the adverse drug reaction reporting and monitoring system, in the Dermatology department of Kasturba Hospital, Manipal, by a clinical pharmacist, using different promotional activities. Documented adverse drug reactions were assessed and analyzed for incidence, purpose of visit, types, drug classes, individual drug causing adverse drug reactions, type of cutaneous reaction, and various predisposing factors. Management and outcome of the adverse drug reactions were also studied. Adverse drug reactions were also assessed for causality, using Naranjo′s scale, severity, and preventability, using Hartwig et al. scale. Adverse drug reaction attributes to 77% of the hospital visit. Incidence of reported cutaneous adverse drug reactions, were 2.85%. Majority of the adverse drug reactions (96% were of type B. Antibiotics (30%, were the common class of drugs, causing a cutaneous adverse drug reactions. Maximum number of adverse drug reactions were due to Acetaminophen, Amoxicillin, antitubercular drugs, and Phenytoin. Most of the adverse drug reactions were managed by withdrawal of drug (81%, and 58% patients were recovered from the reaction. Naranjos scale classifies, 29 as probable, 21 as possible, and 3 as definite adverse drug reactions. Most of the adverse drug reactions were of moderate severity, however 13 adverse drug reactions were severe. All the adverse drug reactions were probably preventable on extreme caution.

  8. Pharmacogenetics of idiosyncratic adverse drug reactions.

    Science.gov (United States)

    Pirmohamed, Munir

    2010-01-01

    Idiosyncratic adverse drug reactions are unpredictable and thought to have an underlying genetic etiology. With the completion of the human genome and HapMap projects, together with the rapid advances in genotyping technologies, we have unprecedented capabilities in identifying genetic predisposing factors for these relatively rare, but serious, reactions. The main roadblock to this is the lack of sufficient numbers of well-characterized samples from patients with such reactions. This is now beginning to be solved through the formation of international consortia, including developing novel ways of identifying and recruiting patients affected by these reactions, both prospectively and retrospectively. This has been led by the research on abacavir hypersensitivity - its association with HLA-B*5701 forms the gold standard of how we need to identify associations and implement them in clinical practice. Strong genetic predisposing factors have also been identified for hypersensitivity reactions such as are associated with carbamazepine, allopurinol, flucloxacillin, and statin-induced myopathy. However, for most other idiosyncratic adverse drug reactions, the genetic effect sizes have been low to moderate, although this may partly be due to the fact that only small numbers have been investigated and limited genotyping strategies have been utilized. It may also indicate that genetic predisposition will be dependent on multiple genes, with complex interactions with environmental factors. Irrespective of the strength of the genetic associations identified with individual idiosyncratic adverse drug reactions, it is important to undertake functional investigations to provide insights into the mechanism(s) of how the drug interacts with the gene variant to lead to a phenotype, which can take a multitude of clinical forms with variable severity. Such investigations will be essential in preventing the burden caused by idiosyncratic reactions, both in healthcare and in industry

  9. Third generation cephalosporin resistant Enterobacteriaceae and multidrug resistant gram-negative bacteria causing bacteremia in febrile neutropenia adult cancer patients in Lebanon, broad spectrum antibiotics use as a major risk factor, and correlation with poor prognosis

    Directory of Open Access Journals (Sweden)

    Rima eMoghnieh

    2015-02-01

    Full Text Available Bacteremia remains a major cause of life-threatening complications in patients receiving anticancer chemotherapy. The spectrum and susceptibility profiles of causative microorganisms differ with time and place. Data from Lebanon are scarce. We aim at evaluating the epidemiology of bacteremia in cancer patients in a university hospital in Lebanon, emphasizing antibiotic resistance and risk factors of multi-drug resistant organism (MDRO-associated bacteremia.This is a retrospective study of 75 episodes of bacteremia occurring in febrile neutropenic patients admitted to the hematology-oncology unit at Makassed General Hospital, Lebanon, from October 2009-January 2012.It corresponds to epidemiological data on bacteremia episodes in febrile neutropenic cancer patients including antimicrobial resistance and identification of risk factors associated with third generation cephalosporin resistance (3GCR and MDRO-associated bacteremia. Out of 75 bacteremias, 42.7% were gram-positive (GP, and 57.3% were gram-negative (GN. GP bacteremias were mostly due to methicillin-resistant coagulase negative staphylococci (28% of total bacteremias and 66% of GP bacteremias. Among the GN bacteremias, Escherichia coli (22.7% of total, 39.5% of GN organisms and Klebsiellapneumoniae(13.3% of total, 23.3% of GN organisms were the most important causative agents. GN bacteremia due to 3GC sensitive (3GCS bacteria represented 28% of total bacteremias, while 29% were due to 3GCR bacteria and 9% were due to carbapenem-resistant organisms. There was a significant correlation between bacteremia with MDRO and subsequent intubation, sepsis and mortality. Among potential risk factors, only broad spectrum antibiotic intake >4 days before bacteremia was found to be statistically significant for acquisition of 3GCR bacteria. Using carbapenems or piperacillin/ tazobactam>4 days before bacteremia was significantly associated with the emergence of MDRO (p value<0.05.

  10. Value of dual time point F-18 FDG-PET/CT imaging for the evaluation of prognosis and risk factors for recurrence in patients with stage I non-small cell lung cancer treated with stereotactic body radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Satoh, Yoko, E-mail: pecampecam@yahoo.co.jp [PET Center, Kofu Neurosurgical Hospital, ZIP Code 400-0805, Sakaori 1-16-18, Kofu city, Yamanashi Prefecture (Japan); Nambu, Atsushi, E-mail: nambu-a@gray.plala.or.jp [Department of Radiology, University of Yamanashi, ZIP Code 409-3898, Yamanashi University Faculty of Medicine, Shimokato 1110, Chuo City, Yamanashi Prefecture (Japan); Onishi, Hiroshi, E-mail: honishi@yamanashi.ac.jp [Department of Radiology, University of Yamanashi, ZIP Code 409-3898, Yamanashi University Faculty of Medicine, Shimokato 1110, Chuo City, Yamanashi Prefecture (Japan); Sawada, Eiichi, E-mail: e_sawaday_61674@ybb.ne.jp [Department of Radiology, University of Yamanashi, ZIP Code 409-3898, Yamanashi University Faculty of Medicine, Shimokato 1110, Chuo City, Yamanashi Prefecture (Japan); Tominaga, Licht, E-mail: lichtt@gmail.com [Department of Radiology, University of Yamanashi, ZIP Code 409-3898, Yamanashi University Faculty of Medicine, Shimokato 1110, Chuo City, Yamanashi Prefecture (Japan); Kuriyama, Kengo, E-mail: kuriyama@yamanashi.ac.jp [Department of Radiology, University of Yamanashi, ZIP Code 409-3898, Yamanashi University Faculty of Medicine, Shimokato 1110, Chuo City, Yamanashi Prefecture (Japan); Komiyama, Takafumi, E-mail: takafumi-ymu@umin.ac.jp [Department of Radiology, Kofu Municipal Hospital, ZIP Code 400-0832, Masutsubo-cho 366, Kofu City, Yamanashi Prefecture (Japan); Marino, Kan, E-mail: marino-akrf@ych.pref.yamanashi.jp [Department of Radiology, Yamanashi Prefectural Hospital, ZIP Code 400-8506, Fujimi 1-1-1, Kofu City, Yamanashi Prefecture (Japan); Aoki, Shinichi, E-mail: aokis@yamanashi.ac.jp [Department of Radiology, University of Yamanashi, ZIP Code 409-3898, Yamanashi University Faculty of Medicine, Shimokato 1110, Chuo City, Yamanashi Prefecture (Japan); and others

    2012-11-15

    Purpose: To investigate prognostic and risk factors for recurrence after stereotactic body radiation therapy (SBRT) in patients with stage I non-small cell lung carcinoma (NSCLC), focusing on dual time point [18]F-fluorodeoxyglucose positron emission tomography (FDG PET). Materials and methods: We prospectively evaluated 57 patients with stage I NSCLC (45 T1N0M0 and 12 T2N0M0) who had undergone pretreatment FDG-PET/CT and were subsequently treated with SBRT. All patients received a whole-body PET/CT scan at 60 min and a whole-lung at 120 min after the injection. The maximum standardized uptake value (SUV) and retention index (RI) of the lesions were calculated. Local recurrence, regional lymph node metastasis, distant metastasis, and the recurrence pattern were evaluated. Cox proportional hazard regression analyses were performed to evaluate prognostic factors or risk factors of recurrence. Results: During the median follow-up period of 27 months, local recurrence, regional lymph node metastasis, and distant metastasis were seen in 17 (30%), 12 (21%), and 17 (30%) of the 57 patients, respectively. The 3-year overall survival rate was 63.4%. SUV{sub max} did not affect any recurrence, DFS, OS, or CSS. RI significantly predicted higher distant metastasis (HR 47.546, p = 0.026). In contrast, RI tended to predict lower local recurrence (HR 0.175, p = 0.246) and regional lymph node metastasis (HR 0.109, p = 0.115). Conclusions: SUV{sub max} at staging FDG-PET does not predict any recurrence, DFS, OS or CSS. In contrast, higher RI predicts higher distant metastasis and tended to predict lower local or regional lymph node metastasis.

  11. High expression of RelA/p65 is associated with activation of nuclear factor-κB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis

    OpenAIRE

    Weichert, W; Boehm, M.; Gekeler, V; Bahra, M.; Langrehr, J; Neuhaus, P; Denkert, C; Imre, G.; Weller, C; Hofmann, H-P; Niesporek, S; Jacob, J.; Dietel, M; Scheidereit, C.; Kristiansen, G

    2007-01-01

    Activation of nuclear factor-κB (NF-κB) signaling was observed in pancreatic adenocarcinoma cell lines and tumours. However, information on the expression of RelA/p65, the major transcription activating NF-κB subunit, in these carcinomas and possible correlations thereof with NF-κB activation and patient survival is not available. To provide this missing translational link, we analysed expression of RelA/p65 in 82 pancreatic adenocarcinomas by immunohistochemistry. Moreover, we measured activ...

  12. Adverse Childhood Experiences and Hallucinations

    Science.gov (United States)

    Whitfield, C.L.; Dube, S.R.; Felitti, V.J.; Anda, R.F.

    2005-01-01

    Objective:: Little information is available about the contribution of multiple adverse childhood experiences (ACEs) to the likelihood of reporting hallucinations. We used data from the ACE study to assess this relationship. Methods:: We conducted a survey about childhood abuse and household dysfunction while growing up, with questions about health…

  13. Childhood adversities as a predictor of disability retirement

    OpenAIRE

    Harkonmäki, K.; Korkeila, K.; Vahtera, J; Kivimäki, M; Suominen, S; Sillanmäki, L.; Koskenvuo, M

    2007-01-01

    BACKGROUND: There is a large body of research on adulthood risk factors for retirement due to disability, but studies on the effect of adverse childhood experiences are scarce. AIM: To examine whether adverse childhood experiences predict disability retirement. METHODS: Data were derived from the Health and Social Support Study. The information was gathered from postal surveys in 1998 (baseline) and in 2003 (follow-up questionnaire). The analysed data consisted of 8817 non-retired respondents...

  14. Factors influencing the short-term prognosis of interventional therapy for malignant obstructive jaundice:a multivariate analysis%恶性梗阻性黄疸介入治疗短期疗效影响因素的研究

    Institute of Scientific and Technical Information of China (English)

    刘洋; 孔亚林; 张洪义; 张宏义; 何晓军; 徐新保; 刘承利; 冯志强; 肖梅; 张辉

    2011-01-01

    Objective: To discuss the correlative factors affecting the short-term prognosis in treating malignant obstructive jaundice with percutaneous transhepatic biliary drainage (PTBD) and percutaneous transhepatic biliary stenting (PTBS). Methods: During the period of June 2004-June 2009, PTBD and PTBS were performed in 107 patients. The clinical date were reviewed and analyzed. According to the reduction degree of serum bilirubin and survival condition in 30 days.the patients were divided into effective Group and ineffective group. Single factor affecting the short-term prognosis was analyzed by using x2 test and multi-factors were analyzed by using non-conditional logistic regression mode. Results: Single variable analysis showed that age,sex,time of obstruction, way of drainage.preoperative biliary infection,Child-Pugh grade, TBIL, HGB and Cr level were of statistical significance.The logistic regression analysis showed that there were obvious correlation a-mong preoperative biliary infection, Child-grade 3=9 and Cr > 111 μ mol/L. Conclusion* The infection of the bile duct before operation,Child-grade 3=9 and Cr > 111 μ mol/L carry a close relationship with the short-term prognosis of PTBD and PTBS. Therefore, an overall preoperative evaluation for malignant obstructive jaundice is of great importance.%目的:探讨影响恶性梗阻性黄疸经皮肝穿胆道引流(PTBD)联合胆道支架置入术(PTBS)短期疗效的相关因素.方法:分析2004年6月-2009年6月经PTBD和PTBS治疗的恶性梗阻性黄疸患者107例,参照胆红素下降程度和术后30 d内生存情况分为短期治疗有效(91例)和无效(16例)2组,应用卡方检验进行单因素分析,非条件Logistic进行多因素分析.结果:单因素分析显示患者年龄、性别、梗阻时间、梗阴部位、术前胆道感染和肝功能Child-Pugh评分、TBIL,HGB,Cr 9个因素与恶性梗阻性黄疸介入治疗预后相关.多因素分析示术前胆道

  15. Prognosis of trochanteric pain in primary care

    NARCIS (Netherlands)

    B.W.V. Schouten (Boris); A.M. Bohnen (Arthur); B.W. Koes (Bart); J.A.N. Verhaar (Jan); S.M. Bierma-Zeinstra (Sita); A.M. Lievense (Annet)

    2005-01-01

    textabstractBACKGROUND: Trochanteric pain is the second most important diagnosis of hip problems presenting in primary care, but its incidence and prognosis in this context is largely unknown. AIM: To determine the 1- and 5-year prognoses of trochanteric pain and the predictive var

  16. Factors of poor prognosis of visceral leishmaniasis among children under 12 years of age. A retrospective monocentric study in Belo Horizonte, State of Minas Gerais, Brazil, 2001-2005

    Directory of Open Access Journals (Sweden)

    Alexandre Sérgio da Costa Braga

    2013-01-01

    Full Text Available INTRODUTION: A major concern with the visceral leishmaniasis (VL is its high lethality rate, even with proper treatment. Low age, prior malnutrition, disease duration prior to diagnosis, severe anemia, fever for more than 60 days, diarrhea and jaundice are known poor prognostic factors. The goals of this study are to describe the clinical and laboratory characteristics of VL among children under 12 years of age and to identify the factors associated with VL poor outcome. METHODS: Two hundred and fifty children under 12 years of age with confirmed VL admitted to Hospital João Paulo II (FHEMIG, Belo Horizonte, Brazil, between January 2001 and December 2005 were evaluated retrospectively. The primary outcome was the poor clinical evolution: sepsis, and/or pneumonia, and/or urinary tract infection, and/or of bleeding (expect epistaxis, and/or severe neutropenia (neutrophil < 500 cells/mm3. Odds ratio (crude and adjusted and its 95% confidence interval for each variable were calculated. Values less than 0.05 were considered significant. RESULTS: Average age was 3.3 years (3.6 months-11.6 years, 71.2% were younger than 5 years and 47.2% lived in Metropolitan Area of Belo Horizonte. The mean fatality rate was 3.6%. Sixty-six (26.4% patients presented poor evolution. After a multivariate analysis, age <18 months, abnormal respiratory physical examination on hospital admission, and platelets <85,000/mm3 remained associated with increased chance of poor evolution. CONCLUSIONS: The results suggest that patients aged between 12 and 18 months, with platelet counts bellow 85,000/mm3, and respiratory abnormalities at admission should be considered potentially severe.

  17. 转移性去势抵抗性前列腺癌化疗后预后的影响因素%Factors Influencing Prognosis of Metastatic Castration-resistant Prostate Cancer after Chemotherapy

    Institute of Scientific and Technical Information of China (English)

    庞华

    2014-01-01

    Objective To investigate prognostic factors of metastatic castration-resistant prostate cancer ( mCRPC ) trea-ted with docetaxel chemotherapy .Methods Age,Gleason score ,prostate-specific antigen ,blood baseline condition and hormone-sensitive time of 46 patients with mCRPC were recorded .Results Overall survival time of all patients was 3-45 months,the aver-age survival time was (21.34 ±2.13) months,median survival time was 19.36 months;cox regression analysis showed that Glea-son score,hemoglobin,hormone-sensitive time were related with the patient's survival time,RR values were 1.782,2.363 and 2.012,and P<0.05.Conclusion Gleason score,hemoglobin concentration ,and hormone-sensitive time before chemotherapy are prognostic factors of metastatic castration resistant prostate cancer .%目的:探讨采用多西紫杉醇化疗的转移性去势抵抗性前列腺癌( metastatic castration-resistant prostate canc-er,MCRPC)患者预后影响因素。方法以转移性去势抵抗性前列腺癌患者46例作为观察对象,记录患者化疗前年龄、Gleason评分、前列腺特异抗原(prostate-specific antigen,PSA)值、血常规等基线情况及激素敏感时间。结果患者总生存时间为3~45个月,平均生存期为(21.34±2.13)个月,中位生存时间为19.36个月;Cox回归结果提示,Gleason评分、血红蛋白水平、激素敏感时间与患者生存时间相关,RR值分别为1.782、2.363和2.012,且P<0.05。结论多西他赛化疗前Gleason评分、血红蛋白浓度及激素敏感时间,是转移性去势抵抗性前列腺癌患者的预后因素。

  18. 产褥期妇科急腹症相关因素及预后分析%Related factors and prognosis of gynecologic acute abdominal diseases in puerperium

    Institute of Scientific and Technical Information of China (English)

    王兴旺; 张莹

    2012-01-01

    目的 分析产褥期妇科急腹症发病的相关因素并提出预防办法.方法 回顾性总结2007-03~2012-03间因产褥期妇科急腹症入住我院的患者42例,就其发病相关因素及预后加以分析.结果 42例患者中有26例行手术治疗,16例行非手术治疗.最后诊断为卵巢囊肿蒂扭转22例(并化脓性阑尾炎1例),(单纯)产褥感染11例,晚期产后出血5例(并感染3例),卵巢囊肿及卵巢癌破裂各1例,浆膜下子宫肌瘤蒂扭转1例,盆腔结核1例.结论产褥期最常见的妇科急腹症是卵巢囊肿蒂扭转,其次是盆腔感染性疾病和晚期产后出血.%Objective To explore the related factors and preventive measures of gynecologic acute abdominal diseases factors in puerperium. Methods The clinical data of 42 patients with gynecologic acute abdominal diseases in puerperium in our hospital from March 2007 to March 2012 were retrospectively analyzed. Results Of 42 patients, 26 patients underwent surgery, and 16 patients were given non-surgical treatment. Finally,22 patients were diagnosed as torsion of the pedicle of ovarian cyst ( one case of suppurative appendicitis );11 patients with ( simple ) puerperal infection ;5 patients with late postpartum hemorrhage ( including 3 cases of infection );one patient with rupture of ovarian cyst and one patient with ovarian cancer; one patient with torsion of subserous hysteromyoma and one patient with pelvic tuberculosis. Conclusion Torsion of the pedicle of ovarian cyst is the most common gynecologic acute abdominal disease in puerperium, followed by pelvic inflammatory disease and late postpartum hemorrhage.

  19. Effects of tongxinluo on C-reactive protein and clinical prognosis in patients after coronary stenting

    International Nuclear Information System (INIS)

    Objective: To investigate the effects of Tongxinluo on C reactive protein(CRP)and clinical prognosis in patients after coronary stenting. Methods: From January 2003 to December 2004, 132 patients in our department diagnosed as coronary artery disease (including acute myocardial infarction, unstable angina pectoris and stable angina pectoris)were divided into two groups: Tongxinluo group and control group. The control group received routine treatment, while Tongxinluo group based on routine treatment was administrated with Tongxinluo capsule in combination for 6 months. Results: CRP level was much lower in Tongxinluo group together with apparent decrease of the major adverse cardiac event (MACE)rate in 6 months' follow-up than those of the control group, but showing no difference in coronary arterial restenosis between the two groups at 6 months after coronary stenting. Conclusion: Tongxinluo has favorable effects to decrease the CRP level and improve clinical efficiency together with prognosis for patients after coronary stenting. (authors)

  20. Adverse Effects of Plasma Transfusion

    OpenAIRE

    Pandey, Suchitra; Vyas, Girish N

    2012-01-01

    Plasma utilization has increased over the last two decades, and there is a growing concern that many plasma transfusions are inappropriate. Plasma transfusion is not without risk, and certain complications are more likely with plasma than other blood components. Clinical and laboratory investigations of the patients suffering reactions following infusion of fresh frozen plasma (FFP) define the etiology and pathogenesis of the panoply of adverse effects. We review here the pathogenesis, diagno...

  1. Optimal Contracting under Adverse Selection

    DEFF Research Database (Denmark)

    Lenells, Jonatan; Stea, Diego; Foss, Nicolai Juul

    2015-01-01

    We study a model of adverse selection, hard and soft information, and mentalizing ability--the human capacity to represent others' intentions, knowledge, and beliefs. By allowing for a continuous range of different information types, as well as for different means of acquiring information, we...... that information. This strategy affects the properties of the optimal contract, which grows closer to the first best. This research provides insights into the implications of mentalizing for agency theory....

  2. Cardiovascular adverse effects of phenytoin.

    Science.gov (United States)

    Guldiken, B; Rémi, J; Noachtar, Soheyl

    2016-05-01

    Phenytoin is an established drug in the treatment of acute repetitive seizures and status epilepticus. One of its main advantages over benzodiazepines is the less sedative effect. However, the possibility of cardiovascular adverse effects with the intravenous use of phenytoin cause a reluctance to its usage, and this has lead to a search for safer anticonvulsant drugs. In this study, we aimed to review the studies which evaluated the safety of phenytoin with respect to cardiovascular adverse effects. The original clinical trials and case reports listed in PUBMED in English language between the years of 1946-2014 were evaluated. As the key words, "phenytoin, diphenylhydantoin, epilepsy, seizure, cardiac toxicity, asystole, arrhythmia, respiratory arrest, hypotension, death" were used. Thirty-two clinical trials and ten case reports were identified. In the case reports, a rapid infusion rate (>50 mg/min) of phenytoin appeared as the major cause of increased mortality. In contrast, no serious cardiovascular adverse effects leading to death were met in the clinical trials which applied the recommended infusion rate and dosages. An infusion rate of 50 mg/min was reported to be safe for young patients. For old patients and patients with a cardiovascular co-morbidity, a slower infusion rate was recommended with a careful follow-up of heart rhythm and blood pressure. No cardiovascular adverse effect was reported in oral phenytoin overdoses except one case with a very high serum phenytoin level and hypoalbuminemia. Phenytoin is an effective and well tolerated drug in the treatment of epilepsy. Intravenous phenytoin is safe when given at recommended infusion rates and doses. PMID:26645393

  3. ADVERSE SELECTION AND MANAGERIAL INCENTIVES

    OpenAIRE

    Javier M. López Cuñat

    2000-01-01

    We analyze managerial contracts (i.e. incentive schemes based on a linear combination of profits and sales) under asymmetric information about costs. In the competitive setting with ex ante symmetric information, standard strategic effects appear. Under adverse selection in both, monopolistic and competitive settings, we show that, in order to decrease the manager's expected informational rents, the owner will optimally pay the manager to keep sales low or, on the contrary, keep them high. Mo...

  4. 比较青年与中老年发生急性脑出血的危险因素及其预后%Risk factors and prognosis of acute cerebral hemorrhage in young and middle aged and elderly patients

    Institute of Scientific and Technical Information of China (English)

    莎其尔; 乌达木

    2015-01-01

    Objective: To investigate the risk factors and prognosis of acute cerebral hemorrhage in young and middle aged and elderly patients.Methods: The clinical data of 393 patients with acute cerebral hemorrhage admitted to our hospital from January 2010 June to were retrospectively analyzed. The patients were divided into two groups: young group (aged 45 years old,n=155) and middle aged group (aged over 45 years,n=238). Risk factors and hospital mortality of the two groups were analyzed and compared. Results: Compared with the analysis, the risk factors of acute cerebral hemorrhage in the youth group had a large amount of alcohol consumption and smoking history. The risk factors of acute cerebral hemorrhage in the young group were hypertension, hyperlipidemia, and the difference was statistically significant (P<0.05). The mortality rate in the young group was 3.2%, significantly lower than that in the middle and old aged group 8.4%. The difference was statistically significant (P<0.05).Conclusion: Hypertension is a risk factor of cerebral hemorrhage in all ages, especially in the middle and old people. The risk factors of acute cerebral hemorrhage in young group were also a large number of drinking history, smoking history. The prognosis of patients with acute cerebral hemorrhage was significantly better than that in elderly patients.%目的:探讨分析青年与中老年发生急性脑出血的危险因素及其预后。方法对我院2010年1月—2015年6月期间收治的393例急性脑出血患者的临床资料予以回顾性分析,根据患者年龄分为两组:青年组(年龄不超过45岁,n=155)、中老年组(年龄超过45岁, n=238)。分析比较两组发病的危险因素及住院死亡率。结果经分析比较可知,青年组发生急性脑出血的危险因素有大量饮酒史、吸烟史,中老年组发生急性脑出血的危险因素是高血压、高脂血症,组间对比差异有统计学意义(P<0.05)。

  5. Long-term prognosis of acute back pain in patients seen in general practice

    DEFF Research Database (Denmark)

    Schiøttz-Christensen, Berit; Nielsen, Gunnar Lauge; Hansen, Vivian Kjær;

    1999-01-01

    OBJECTIVES: We aimed to examine the prognosis of acute low back pain (LBP) in patients in general practice and to identify prognostic factors associated with the long-term prognosis based on information immediately available to the GP. METHOD: We conducted a prospective cohort study in general......% remained on sick leave. At the 1-year follow-up, 45% of the patients continued to complain of LBP. Logistic regression analyses showed that the factors most significantly associated with poor long-term LBP outcome were (i) severity of LBP at inclusion, (ii) assessments by the GP of susceptibility to...... develop chronic LBP and (iii) a history of LBP having caused previous sick leave. CONCLUSIONS: LBP in general practice has a good prognosis with regard to sick leave, but a high proportion of patients continue to complain of LBP. We were not able to identify objective measures that strongly predict the...

  6. Long-term prognosis of acute low back pain in patients seen in general practice

    DEFF Research Database (Denmark)

    Schiøttz-Christensen, Berit; Nielsen, G L; Hansen, V K;

    1999-01-01

    OBJECTIVES: We aimed to examine the prognosis of acute low back pain (LBP) in patients in general practice and to identify prognostic factors associated with the long-term prognosis based on information immediately available to the GP. METHOD: We conducted a prospective cohort study in general......% remained on sick leave. At the 1-year follow-up, 45% of the patients continued to complain of LBP. Logistic regression analyses showed that the factors most significantly associated with poor long-term LBP outcome were (i) severity of LBP at inclusion, (ii) assessments by the GP of susceptibility to...... develop chronic LBP and (iii) a history of LBP having caused previous sick leave. CONCLUSIONS: LBP in general practice has a good prognosis with regard to sick leave, but a high proportion of patients continue to complain of LBP. We were not able to identify objective measures that strongly predict the...

  7. 热休克因子(HSF1)在乳腺癌中的表达及与预后的关系%Expression of heat shock factor 1 and its relation with prognosis in breast cancer patients

    Institute of Scientific and Technical Information of China (English)

    徐敏; 王树滨; 刘雅洁; 陈亦欣; 郑瑾; 白桦

    2007-01-01

    目的:探讨热休克因子(heat shock factor 1,HSF1)在乳腺癌中的表达,及其在乳腺癌预后中所起的作用.方法:采用免疫组织化学方法检测62例手术切除的乳腺癌组织中HSF1的表达,探讨其与临床病理特征的关系及对预后的影响.结果:HSF,在乳腺癌组织中的阳性表达率为29.0%(18/62).HSF1表达与月经状况存在相关(P=0.004),但与肿瘤大小、淋巴结转移个数以及组织学分级之间均不具相关性.HSF1阴性表达组无病生存期及总生存期均明显优于HSF1阳性表达组(P=0.0057及P=0.0251).Cox回归单因素分析显示淋巴结转移个数、组织学分级、肿瘤大小、HSF1阳性表达及TNM分期与无病生存期及总生存期均明显相关;Cox回归多因素分析表明腋淋巴结转移个数、组织学分级、肿瘤大小与无病生存期及总生存期明显相关,而HSF1阳性表达及TNM分期最终未进入Cox回归模型.结论:HSF1在乳腺癌中有一定程度的表达,且HSF1表达与乳腺癌患者无病生存期及总生存期的缩短有关,有可能成为判断乳腺癌患者预后的指标.

  8. Natural History of Cardiac and Respiratory Involvement, Prognosis and Predictive Factors for Long-Term Survival in Adult Patients with Limb Girdle Muscular Dystrophies Type 2C and 2D

    Science.gov (United States)

    Fayssoil, Abdallah; Ogna, Adam; Chaffaut, Cendrine; Chevret, Sylvie; Guimarães-Costa, Raquel; Leturcq, France; Wahbi, Karim; Prigent, Helene; Lofaso, Frederic; Nardi, Olivier; Clair, Bernard; Behin, Anthony; Stojkovic, Tanya; Laforet, Pascal; Orlikowski, David; Annane, Djillali

    2016-01-01

    Background Type 2C and 2D limb girdle muscular dystrophies (LGMD) are a group of autosomal recessive limb girdle muscular dystrophies manifested by proximal myopathy, impaired respiratory muscle function and cardiomyopathy. The correlation and the prognostic impact of respiratory and heart impairment are poorly described. We aimed to describe the long-term cardiac and respiratory follow-up of these patients and to determine predictive factors of cardio-respiratory events and mortality in LGMD 2C and 2D. Methods We reviewed the charts of 34 LGMD patients, followed from 2005 to 2015, to obtain echocardiographic, respiratory function and sleep recording data. We considered respiratory events (acute respiratory failure, pulmonary sepsis, atelectasis or pneumothorax), cardiac events (acute heart failure, significant cardiac arrhythmia or conduction block, ischemic stroke) and mortality as outcomes of interest for the present analysis. Results A total of 21 patients had type 2C LGMD and 13 patients had type 2D. Median age was 30 years [IQR 24–38]. At baseline, median pulmonary vital capacity (VC) was 31% of predicted value [20–40]. Median maximal inspiratory pressure (MIP) was 31 cmH2O [IQR 20.25–39.75]. Median maximal expiratory pressure (MEP) was 30 cm H2O [20–36]. Median left ventricular ejection fraction (LVEF) was 55% [45–64] with 38% of patients with LVEF <50%. Over a median follow-up of 6 years, we observed 38% respiratory events, 14% cardiac events and 20% mortality. Among baseline characteristics, LVEF and left ventricular end diastolic diameter (LVEDD) were associated with mortality, whilst respiratory parameters (VC, MIP, MEP) and the need for home mechanical ventilation (HMV) were associated with respiratory events. Conclusion In our cohort of severely respiratory impaired type 2C and 2D LGMD, respiratory morbidity was high. Cardiac dysfunction was frequent in particular in LGMD 2C and had an impact on long-term mortality. Trial Registration

  9. A prospective survey of delayed adverse reactions to iohexol in urography and computed tomography

    International Nuclear Information System (INIS)

    We investigated 7505 inpatients who underwent intravenous urography or contrast-enhanced computed tomography to assess risk factors for delayed adverse drug reactions to iohexol, a non-ionic iodinated contrast medium. Focusing on delayed adverse reactions, all adverse events were prospectively investigated for 7 days after injection of iohexol. To explore the relevant risk factors, the relationship between occurrence of adverse reactions to iohexol and 17 different variables was evaluated by logistic regression analysis. To assess the influence of seasonal factors, adverse reactions were separately evaluated during two periods: February to April (the pollinosis period in Japan) and July to September (the non-pollinosis period). The prevalence of delayed adverse events and delayed adverse reactions was 3.5 and 2.8%, respectively, whereas the prevalence of adverse events and adverse reactions was 5.7 and 5.0%, respectively. Multivariate analysis showed that six parameters had a significant influence on delayed adverse reactions to iohexol, including (a) a history of allergy, (b) season, (c) radiographic procedure, (d) age, (e) concomitant surgery or other invasive procedures, and (f) concomitant medication. The prevalence of delayed reactions was lower than in previous large-scale studies. Significant risk factors included a history of allergy and performance of radiography during the pollinosis period, suggesting that allergy was involved in delayed adverse reactions. The type of radiographic procedure also had an influence. (orig.)

  10. A prospective survey of delayed adverse reactions to iohexol in urography and computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Munechika, Hirotsugu [Department of Radiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawaku, Tokyo 142-8555 (Japan); Hiramatsu, Yoshihiro [Second Department of Radiology, Toho University School of Medicine, 5-21-16 Omorinishi, Otaku, Tokyo 143-8541 (Japan); Kudo, Sho [Department of Radiology, Saga Medical School, 5-1-1 Nabeshima, Saga City 849-8501 (Japan); Sugimura, Kazuro [Department of Radiology, Kobe University School of Medicine, 7-5-1 Kusunokicho, Chuoku, Kobe City 650-0017 (Japan); Hamada, Chikuma [Department of Pharmacoepidemiology, School of Public Health, Kyoto University, Sakyo-ku, Kyoto 606-8501 (Japan); Yamaguchi, Koichi [Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata City 990-9585 (Japan); Katayama, Hitoshi [Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyoku, Tokyo 113-8421 (Japan)

    2003-01-01

    We investigated 7505 inpatients who underwent intravenous urography or contrast-enhanced computed tomography to assess risk factors for delayed adverse drug reactions to iohexol, a non-ionic iodinated contrast medium. Focusing on delayed adverse reactions, all adverse events were prospectively investigated for 7 days after injection of iohexol. To explore the relevant risk factors, the relationship between occurrence of adverse reactions to iohexol and 17 different variables was evaluated by logistic regression analysis. To assess the influence of seasonal factors, adverse reactions were separately evaluated during two periods: February to April (the pollinosis period in Japan) and July to September (the non-pollinosis period). The prevalence of delayed adverse events and delayed adverse reactions was 3.5 and 2.8%, respectively, whereas the prevalence of adverse events and adverse reactions was 5.7 and 5.0%, respectively. Multivariate analysis showed that six parameters had a significant influence on delayed adverse reactions to iohexol, including (a) a history of allergy, (b) season, (c) radiographic procedure, (d) age, (e) concomitant surgery or other invasive procedures, and (f) concomitant medication. The prevalence of delayed reactions was lower than in previous large-scale studies. Significant risk factors included a history of allergy and performance of radiography during the pollinosis period, suggesting that allergy was involved in delayed adverse reactions. The type of radiographic procedure also had an influence. (orig.)

  11. Curva de sobrevida e fatores prognósticos no lúpus eritematoso sistêmico infanto-juvenil Survival curve and prognosis factors in the childhood systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Simone Appenzeller

    2005-08-01

    Full Text Available OBJETIVO: analisar as curvas de sobrevida em uma amostra de lúpus eritematoso sistêmico (LES infanto-juvenil, as variáveis clínicas e laboratoriais e o tipo de tratamento associado ao óbito. MÉTODOS: de uma coorte de 519 pacientes seguidos prospectivamente, 55 foram identificados como tendo LES infanto-juvenil. Análise univariada e regressão de Cox foram utilizadas para determinar as variáveis associadas com a sobrevida nesta coorte. RESULTADOS: o óbito foi identificado em 12 dos pacientes (21,8% com LES infanto-juvenil. A causa de óbito em freqüência decrescente foi septicemia em 6 (50%, acidente vascular cerebral (AVC em 4 (33.3% e insuficiência renal em 2 (16,7% pacientes. Na análise univariada o sexo masculino, a presença de infecções e o uso de ciclofosfamida oral estiveram associados ao óbito. Na regressão multivariada, somente o sexo masculino influenciou negativamente o tempo de sobrevida (odds ratio 5,8. CONCLUSÕES: em um período de 27 anos o óbito foi observado em 21,8% dos pacientes. Embora infecções tenham sido causa de morte em metade desses pacientes, a sobrevida não estava associada à presença de infecções ou à insuficiência renal, mas ao fato de o paciente ser do sexo masculino. Prestar maior atenção aos meninos com LES, com diagnóstico, tratamento e seguimento adequados pode influenciar o prognóstico nesses casos.OBJECTIVE: To analyze clinical, laboratory, serological and treatment factors associated with death in a childhood onset childhood systemic lupus erythematosus (SLE population. METHODS: 55 patients out of 519 prospectively followed-up cohorts were identified as having childhood onset SLE in the State University of Campinas. Univariate analysis and Cox regression model were used to determinate the variables associated with death in this cohort. RESULTS: Death occurred in 12 patients (21.8%, caused by sepsis in 6 (50%, stroke in 4 (33.3%, and renal insufficiency in two (16.7% cases. In

  12. Prognosis of acute low back pain: design of a prospective inception cohort study

    Directory of Open Access Journals (Sweden)

    York John

    2006-06-01

    Full Text Available Abstract Background Clinical guidelines generally portray acute low back pain as a benign and self-limiting condition. However, evidence about the clinical course of acute low back pain is contradictory and the risk of subsequently developing chronic low back pain remains uncertain. There are few high quality prognosis studies and none that have measured pain, disability and return to work over a 12 month period. This study aims to provide the first estimates of the one year prognosis of acute low back pain (pain of less than 2 weeks duration in patients consulting primary care practitioners. A secondary aim is to identify factors that are associated with the prognosis of low back pain. Methods/Design The study is a prospective inception cohort study. Consecutive patients consulting general medical practitioners, physiotherapists and chiropractors in the Sydney metropolitan region will complete a baseline questionnaire regarding their back pain. Subsequently these patients will be followed up by telephone 6 weeks, 3 months and 12 months after the initial consultation. Patients will be considered to have recovered from the episode of back pain if they have no pain and no limitation of activity, and have returned to pre-injury work status. Life tables will be generated to determine the one year prognosis of acute low back pain. Prognostic factors will be assessed using Cox regression. Discussion This study will provide the first estimates of the one year prognosis of acute low back pain in a representative sample of primary care patients.

  13. Ouabain protects against adverse developmental programming of the kidney.

    Science.gov (United States)

    Li, Juan; Khodus, Georgiy R; Kruusmägi, Markus; Kamali-Zare, Padideh; Liu, Xiao-Li; Eklöf, Ann-Christine; Zelenin, Sergey; Brismar, Hjalmar; Aperia, Anita

    2010-01-01

    The kidney is extraordinarily sensitive to adverse fetal programming. Malnutrition, the most common form of developmental challenge, retards the formation of functional units, the nephrons. The resulting low nephron endowment increases susceptibility to renal injury and disease. Using explanted rat embryonic kidneys, we found that ouabain, the Na,K-ATPase ligand, triggers a calcium-nuclear factor-κB signal, which protects kidney development from adverse effects of malnutrition. To mimic malnutrition, kidneys were serum deprived for 24 h. This resulted in severe retardation of nephron formation and a robust increase in apoptosis. In ouabain-exposed kidneys, no adverse effects of serum deprivation were observed. Proof of principle that ouabain rescues development of embryonic kidneys exposed to malnutrition was obtained from studies on pregnant rats given a low-protein diet and treated with ouabain or vehicle throughout pregnancy. Thus, we have identified a survival signal and a feasible therapeutic tool to prevent adverse programming of kidney development. PMID:20975704

  14. Tissue microarray analysis of expression of vascular endothelial growth factor and platelet-derived endothelial cell growth factor in a-fetoprotein-negative hepatocellular carcinoma and its relationship with prognosis after radical resection%血管内皮生长因子和血小板衍化内皮生长因子的表达在甲胎蛋白阴性肝细胞癌根治性切除术后预后预测中的作用

    Institute of Scientific and Technical Information of China (English)

    陆清; 徐泱; 周俭; 樊嘉; 纪元; 汤钊猷

    2008-01-01

    Objective To study the expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) and its relationship with the prognosis after radical resection for α-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC). Methods The expression of VEGF and PD-ECGF in 200 patients with AFP-negative HCC proven by surgery and pathology during Jan. 1997 to Dec. 2000 was analyzed retrospectively by high-throughput tissue microarray technology and immnnohistochemistry. Kaplan-Meier method, log-rank test and chi-square test were used to analyze the relationship between the expression of the two angiogenetie factors with the prognosis of AFP-negative HCC. Results Compared with VEGF-positive group and PD-ECGF-positive group,the patients' survivalrate and tumor-free survival rate rather than recurrence rate had no significant difference in the negative-expression group, respectively. The recurrence rate was also higher in the both positive groups than in the both negative groups. Moreover, the patients in both positive groups had a significantly low survival and tumor-free survival rate. Conclusion Positive expression of both VEGF and PD-ECGF indicated high risk of tumor recurrence and a poor prognosis after radical resection for AFP-negative HCC.%目的 探讨血管内皮生长因子(VEGF)和血小板衍化内皮生长因子(PD-ECGF)在甲胎蛋白(AFP)阴性肝细胞癌切除术后预后预测中的作用.方法 利用组织微阵列技术(tissue mi-croarray)和免疫组织化学方法回顾性研究200例AFP阴性肝癌患者肿瘤中VEGF及PD-ECGF的表达情况,分析其与肝细胞癌切除术后预后的关系.结果 V EGF及PD-ECGF表达阳性组与相应阴性组患者之间的生存率和无瘤生存率差异无统计学意义(P>0.05),而VEGF及PD-ECGF表达阳性组的术后复发率比相应阴性组显著增高(P<0.05).VEGF和PD.ECGF同时阳性表达组其复发率更显著高于同时阴性组(P<0.01),其生存

  15. 早期移植肾功能异常的相关因素及其预后%Correlation factors for early graft dysfunction and prognosis after cadaver renal transplantation

    Institute of Scientific and Technical Information of China (English)

    季曙明; 尹广; 殷立平; 陈劲松; 沙国柱; 黎磊石

    1999-01-01

    Objective To investigate the correlation factors for early graft dysfunction after kidney transplantation,and the effects on long-term graft survival.Methods 251 recipients of first cadaver renal graft were divided into 4 groups according to the history of acute rejection(AR)and the concentration of serum creatinine(SCr)in 6 months after transplantation:Groups A and B,having no history of AR with SCr levels at 6th month of<130μmol/L in the former and≥130 μmol/L in the latter,and groups C and D having the history of AR with SCr levels at 6 th month of<130 μmol/L in the former and≥130μmol/L in the latter.All groups had the sanle immunosuppressive protocol.Results SCr level at 10th day after operation in groups A and C maintained normal,while the SCr levels in groups B and D were obviously elevated,which was correlated with acute tubular necrosis(ATN),IgA nephritis,donors' age,postoperative hypotension,AR times and the dosage of cyclosporine A.The one-and three-year survival rate of renal graft in groups D was significantly lower than in groups A,B and C.Conclusion ATN was the commonest cause for early renal graft dysfunction after renal transplantation.The damage to the kidney in the process of renal removal,reperfusion and high dose of cyclospofine A at early stage might affect the recovery of the early renal function.The dysfunction of early renal dysfunction after operation would affect the renal graft long-term survival in the patients having AR in 6 months after operation.%目的 探讨早期移植肾功能异常的相关因素及其对移植肾长期存活的影响.方法 根据术后6个月内有无发生急性排斥反应和6个月时的血肌酐水平(SCr6月n),将251例肾移植患者分为4组:A、B组未发生急性排斥反应,前者SCr6月<130 ìmol/L,后者SCr6月≥130 ìmol/L;C、D组发生急性排斥反应,前者SCr6月<130 ìmol/L,后者SCr6月≥130 ìmol/L.术后各组的免疫抑制方案相同.结果 4个组在冷缺血及热缺

  16. Use of Granulocyte-Colony Stimulating Factor (G-CSF) in patients with cancer at high risk of febrile neutropenia on the basis of high age and complications, recommendations for patients receiving radiotherapy, and adverse events because of G-CSF

    International Nuclear Information System (INIS)

    Neutropenic complications are the primary dose-limiting toxic effects observed in patients treated with systemic cancer chemotherapy. Broad-spectrum antibiotic therapy should be promptly administered to patients with febrile neutropenia (FN). The risk assessment of FN includes the disease characteristics, chemotherapy regimen, individual patient risk factors, and treatment intent. After considering such risk factors of FN, clinicians should appropriately consider the use of granulocytecolony stimulating factor (G-CSF) as a prophylactic or therapeutic measure. Some types of lymphoma can be cured with chemotherapy. The incidence of FN in patients receiving the standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen is approximately 20%. Primary prophylactic use of G-CSF is recommended for patients aged ≥ 65 years having diffuse aggressive lymphoma and treated with curative chemotherapy in an effort to improve their quality of life (QOL). Primary prophylaxis is recommended for the prevention of FN in patients at high risk, on the basis of factors other than age. G-CSF should be avoided in patients receiving concomitant chemotherapy and radiation therapy, particularly in those with cancer involving the mediastinum. The adverse events of G-CSF are generally graded mild to moderate; however, rare life-threatening adverse effects have been published in the literature. A clinical practice guideline for the use of G-CSF was published by the Japan Society of Clinical Oncology in 2013. On the basis of this guideline, the above issues have been discussed in this paper. (author)

  17. Allogeneic bone marrow transplantation for severe aplastic anemia patients with risk factors for poor prognosis: is fludarabine a requirement? Transplante alogênico de medula óssea em portadores de anemia aplásica severa com fatores de mau prognóstico: é necessário fludarabina?

    Directory of Open Access Journals (Sweden)

    Carlos R. de Medeiros

    2008-08-01

    Full Text Available Hematopoietic progenitor cell transplantation from HLA-identical sibling donors cures 70-90% of Severe Aplastic Anemia (sAA patients. Older age, heavy exposure to transfusions, immunosuppression treatment (IST with a long interval from diagnosis to transplant and infection at procedure are associated with poor outcomes. We transplanted 18 patients with sAA and at least one risk factor (RF for poor prognosis (age >35 years, >50 transfusions prior to transplant, unresponsiveness to previous IST and bacterial or fungal infection at transplant from 2001 to 2005, using cyclophosphamide (CY - 5 patients or busulfan plus CY (13 patients. Sixteen patients engrafted, two died with no engraftment, three patients had evidence of graft failure at days +67, +524 and +638 (two died and one was rescued with IST. Grade III/IV mucositis occurred in 39% but neither aGVHD nor cGVHD were observed. The Kaplan-Meier probability of survival was 75% at 2.14 years, with a trend favoring survival by number of RF (1 versus =2 RF (P = 0.06. These results are comparable to recent data reported with fludarabine-based conditioning in patients with poor prognosis sAA. Due to the small sample size, prospective clinical trials with larger cohorts of patients are needed to confirm the real benefits of fludarabine-based conditioning, and also to define the best agent(s to be associated with Fludarabine as preparative regimen for sAA patients with poor prognosis.Transplante de medula óssea de doador irmão HLA-idêntico pode curar 70%-90% dos portadores de anemia aplásica severa (AAs. Pacientes mais idosos, muito transfundidos, longamente tratados com imunossupressão (IS e com infecções ao tempo do transplante têm pior evolução. Nós transplantamos 18 pacientes com AAs e pelo menos um dos fatores associados a pior prognóstico (idade >35 anos, >50 transfusões antes do transplante, falta de resposta à imunossupressão prévia e infecção bacteriana ou fúngica ao

  18. Prognosis of synchronous bilateral breast cancer

    DEFF Research Database (Denmark)

    Holm, Marianne; Tjønneland, Anne; Balslev, Eva;

    2014-01-01

    Currently, no consistent evidence-based guidelines for the management of synchronous bilateral breast cancer (SBBC) exist and it is uncertain how presenting with SBBC affects patients' prognosis. We conducted a review of studies analyzing the association between SBBC and prognosis. The studies that...... reported adjusted effect measures were included in meta-analyses of effect of bilaterality on breast cancer mortality. From 57 initially identified records 17 studies from 11 different countries including 8,050 SBBC patients were included. The quality of the studies varied but was generally low with small...... sample sizes, and lack of consistent, detailed histo-pathological information. When doing meta-analysis on the subgroup of studies that provided adjusted effect estimates on breast cancer mortality (nine studies including 3,631 SBBC cases), we found that bilaterality in itself had a negative impact on...

  19. Treatment and prognosis of pyogenic liver abscess

    OpenAIRE

    Su, Yu-Jang; Lai, Yen-Chun; Lin, Yu-Chia; Yeh, Yu-Hang

    2010-01-01

    Background There are many combinations of treatments for pyogenic liver abscess (PLA). Different treatments are indicated for different clinical courses of PLA. Aims To realize the current prevalence, clinical course, trend of treatment, and prognosis of pyogenic liver abscess (PLA) in Taiwan. Methods We retrospectively reviewed the medical records of 126 patients with PLA. We divided them into four groups: M, MD, MS, and MDS, represented as parenteral antibiotic only, parenteral antibiotic w...

  20. Diabetes, diabetes treatment and breast cancer prognosis

    OpenAIRE

    Luo, Juhua; Virnig, Beth; Hendryx, Michael; Wen, Sijin; Chelebowski, Rowan; Chen, Chu; Rohan, Tomas; Tinker, Lesley; Wactawski-Wende, Jean; Lessin, Lawrence; Margolis, Karen

    2014-01-01

    The objectives of this study are to assess the impact of pre-existing diabetes and diabetes treatment on breast cancer prognosis. 8,108 women with centrally confirmed invasive breast cancer in the Women’s Health Initiative diagnosed between 1998 and 2013 were followed through the date of death or September 20, 2013. Information on diabetes and diabetes therapy were obtained via self-report and face-to-face review of current medication containers, respectively. Cox proportional hazard regressi...

  1. Relationship of serum methotrexate concentration in high-dose methotrexate chemotherapy to prognosis and tolerability: A prospective cohort study in chinese adults with osteosarcoma

    OpenAIRE

    Lin, Feng; Juan, Yue; Zheng, Shui-er; Shen, Zan; Tang, Li-Na; Hui ZHAO; Yao, Yang

    2009-01-01

    Background: Cancer that originates in the bone, termed primary bone cancer, is rare. Osteosarcoma (OS) occurs primarily in growing bone tissue and is more prevalent in children and adolescents. OS in adults is rare, with 3 to 5 cases per million population per year worldwide. There are limited data on treatment-related prognosis and adverse reactions in adults reported in the literature.

  2. Adverse blood transfusion outcomes: establishing causation.

    Science.gov (United States)

    Isbister, James P; Shander, Aryeh; Spahn, Donat R; Erhard, Jochen; Farmer, Shannon L; Hofmann, Axel

    2011-04-01

    The transfusion of allogeneic red blood cells (RBCs) and other blood components is ingrained in modern medical practice. The rationale for administering transfusions is based on key assumptions that efficacy is established and risks are acceptable and minimized. Despite the cliché that, "the blood supply is safer than ever," data about risks and lack of efficacy of RBC transfusions in several clinical settings have steadily accumulated. Frequentist statisticians and clinicians demand evidence from randomized clinical trials (RCTs); however, causation for the recognized serious hazards of allogeneic transfusion has never been established in this manner. On the other hand, the preponderance of evidence implicating RBC transfusions in adverse clinical outcomes related to immunomodulation and the storage lesion comes from observational studies, and a broad and critical analysis to evaluate causation is overdue. It is suggested in several circumstances that this cannot wait for the design, execution, and conduct of rigorous RCTs. We begin by examining the nature and definition of causation with relevant examples from transfusion medicine. Deductive deterministic methods may be applied to most of the well-accepted and understood serious hazards of transfusion, with modified Koch's postulates being fulfilled in most circumstances. On the other hand, when several possible interacting risk factors exist and RBC transfusions are associated with adverse clinical outcomes, establishing causation requires inferential probabilistic methodology. In the latter circumstances, the case for RBC transfusions being causal for adverse clinical outcomes can be strengthened by applying modified Bradford Hill criteria to the plethora of existing observational studies. This being the case, a greater precautionary approach to RBC transfusion is necessary and equipoise that justifying RCTs may become problematic. PMID:21345639

  3. Acute Kidney Injury: Epidemiology, Diagnosis, Prognosis, and Future Directions

    Directory of Open Access Journals (Sweden)

    Joana Briosa Neves

    2015-07-01

    Full Text Available Acute kidney injury (AKI is a common problem highly associated with hospitalisation. AKI is the cause of harmful short-term consequences: longer hospital stays, greater disability after discharge, and greater risk of in-hospital mortality, as well as adverse long-term outcomes, such as progression to chronic kidney disease, development of cardiovascular disease, and increased risk of long-term mortality. The concept of AKI has changed since the introduction of the ‘Risk, Injury, Failure, Loss of kidney function, End-stage kidney disease’ (RIFLE classification. More recently, the ‘Kidney Disease Improving Global Outcomes’ (KDIGO classification appears to have provided increased diagnostic sensitivity and outcome-prediction capability. Novel biomarkers and further research on the role of the immune system in AKI may help improve the diagnosis, severity, outcome evaluation, and treatment of the condition. In this review we describe the epidemiology, diagnosis, and prognosis of AKI, as well as possible future directions for its clinical management.

  4. Are Early Relapses in Advanced-Stage Ovarian Cancer Doomed to a Poor Prognosis?

    Science.gov (United States)

    Vidal, Fabien; Guerby, Paul; Luyckx, Mathieu; Haddad, Pascale; Stoeckle, Eberhard; Morice, Philippe; Leblanc, Eric; Lecuru, Fabrice; Daraï, Emile; Classe, Jean Marc; Pomel, Christophe; Filleron, Thomas; Ferron, Gwenael; Querleu, Denis; Rafii, Arash

    2016-01-01

    Objective Early recurrence (ER) after completion of therapeutic regimen in advanced-stage ovarian cancer is a challenging clinical situation. Patients are perceived as invariably having a poor prognosis. We investigated the possibility of defining different prognostic subgroups and the parameters implicated in prognosis of ER patients. Study Design We analyzed a multi-centric database of 527 FIGO stage IIIC and IV ovarian cancer patients. We defined patients relapsing within 12 months as ER and investigated using Cox logistic regression the prognostic factors in ER group. We subsequently divided ER patients into good and poor prognosis groups according to a lower or higher overall survival (OS) at 12 months after relapse and determined parameters associated to poor prognosis. Results The median follow up was 49 months. One hundred and thirty eight patients recurred within 12 months. OS and Disease Free Survival (DFS) were 24.6 and 8.6 months, respectively, in this group of patients. Among the ER patients, 73 had a poor prognosis with an OS after relapse below 12 months (mean OS = 5.2 months) and 65 survived after one year (mean OS = 26.9 months). Residual disease (RD) after debulking surgery and mucinous histological subtype negatively impacted prognosis (HR = 1.758, p = 0.017 and HR = 8.641, p = 0.001 respectively). The relative risk of death within 12 months following relapse in ER patients was 1.61 according to RD status. However, RD did not affect DFS (HR = 0.889, p = 0.5). Conclusion ER in advanced-stage ovarian cancer does not inevitably portend a short-term poor prognosis. RD status after initial cytoreduction strongly modulates OS, that gives additional support to the concept of maximum surgical effort even in patients who will experience early recurrence. The heterogeneity in outcomes within the ER group suggests a role for tumor biology in addition to classical clinical parameters. PMID:26820579

  5. Course of depressive symptoms after myocardial infarction and cardiac prognosis : A latent class analysis

    NARCIS (Netherlands)

    Kaptein, Kirsten I.; de Jonge, Peter; van den Brink, Rob H. S.; Korf, Jakob

    2006-01-01

    Objective: The presence of depressive symptoms after myocardial infarction (MI) is a risk factor for new cardiovascular events. The importance of the course of post-MI depressive symptoms for cardiac prognosis is not clear. We therefore set out to investigate whether different courses of post-MI dep

  6. Hepatic portal venous gas: Physiopathology, etiology, prognosis and treatment

    Institute of Scientific and Technical Information of China (English)

    Bassam Abboud; Jad El Hachem; Thierry Yazbeck; Corinne Doumit

    2009-01-01

    Hepatic portal venous gas (HPVG), an ominous radiologic sign, is associated in some cases with a severe underlying abdominal disease requiring urgent operative intervention. HPVG has been reported with increasing frequency in medical literature and usually accompanies severe or lethal conditions. The diagnosis of HPVG is usually made by plain abdominal radiography, sonography, color Doppler flow imaging or computed tomography (CT) scan. Currently, the increased use of CT scan and ultrasound in the inpatient setting allows early and highly sensitive detection of such severe illnesses and also the recognition of an increasing number of benign and non-life threatening causes of HPVG. HPVG is not by itself a surgical indication and the treatment depends mainly on the underlying disease. The prognosis is related to the pathology itself and is not influenced by the presence of HPVG. Based on a review of the literature, we discuss in this paper the pathophysiology, risk factors, radiographic findings,management, and prognosis of pathologies associated with HPVG.

  7. The prognosis of pancreatic carcinoma in atomic bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Kawanishi, Masahiro; Munaka, Masaki (Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology); Okamoto, Sukeyoshi; Kajiyama, Goro

    1992-03-01

    Prognosis of pancreatic carcinoma in 28 Hiroshima A-bomb survivors was compared with that in background- and tumor size-matched non-exposed patients living in Hiroshima. A-bomb survivors consisted of 13 exposed within 2,000 m from the hypocenter, 12 who had entered the city within 3 days after A-bombing, and 3 not clarified in detail. Survival time was significantly prolonged when tumor resection or surgical internal fistula for obstructive jaundice was performed. The significant therapeutic factor was thus adjusted by using the Cox model to clarify the difference in cumulative survival rates between the exposed and non-exposed groups of pancreatic cancer patients. Median survival was 120 days in the exposed group and 186 days in the non-exposed group. The corresponding figures for 75% and 25% cumulative survival rates were 175 days and 75 days in the exposed group and 238 days and 120 days in the non-exposed group. Prognosis was worse in the exposed group than the non-exposed group. (N.K.).

  8. Ranking Adverse Drug Reactions With Crowdsourcing

    KAUST Repository

    Gottlieb, Assaf

    2015-03-23

    Background: There is no publicly available resource that provides the relative severity of adverse drug reactions (ADRs). Such a resource would be useful for several applications, including assessment of the risks and benefits of drugs and improvement of patient-centered care. It could also be used to triage predictions of drug adverse events. Objective: The intent of the study was to rank ADRs according to severity. Methods: We used Internet-based crowdsourcing to rank ADRs according to severity. We assigned 126,512 pairwise comparisons of ADRs to 2589 Amazon Mechanical Turk workers and used these comparisons to rank order 2929 ADRs. Results: There is good correlation (rho=.53) between the mortality rates associated with ADRs and their rank. Our ranking highlights severe drug-ADR predictions, such as cardiovascular ADRs for raloxifene and celecoxib. It also triages genes associated with severe ADRs such as epidermal growth-factor receptor (EGFR), associated with glioblastoma multiforme, and SCN1A, associated with epilepsy. Conclusions: ADR ranking lays a first stepping stone in personalized drug risk assessment. Ranking of ADRs using crowdsourcing may have useful clinical and financial implications, and should be further investigated in the context of health care decision making.

  9. Factors affecting functional prognosis of patients with hip fracture

    DEFF Research Database (Denmark)

    Kristensen, M T

    2011-01-01

    Having a hip fracture is considered one of the most fatal fractures for elderly people, resulting in impaired function, and increased morbidity and mortality. This challenges clinicians in identifying patients at risk of worse outcome, in order to optimise and intensify treatment in these patient...

  10. Prognosis and prognostic factors in inflammatory bowel disease

    OpenAIRE

    Thompson Nicholas; Wakefield Andrew; Pounder Roy

    1995-01-01

    The chance of normal survival for patients with inflammatory bowel disease is generally good. There may be a small excess mortality for those with Crohn′s disease; however recent studies do not confirm this trend. For those with ulcerative colitis, there may be an excess mortality in the first two years after diagnosis, especially in those who undergo surgery. The necessity for an operation varies, but at least 50% of patients with Crohn′s disease will be an operation in ...

  11. PROGNOSIS OF PRIMARY NON-HODGKIN’S LYMPHOMAS OF THE ORGAN OF VISION

    OpenAIRE

    Ye. Ye. Grishina; I. V. Poddubnaya; E. S. Guzenko; E. G. Gemdzhyan

    2012-01-01

    Much attention has been recently given to the prognosis of extranodal non-Hodgkin’s lymphomas (NHL). All currently available prognostic scales fail to fully characterize the prognosis of primary NHL of the eye and its accessory apparatus.The purpose of this study was to identify prognostic factors for vision and life in patients with primary NHL of the organ of vision. Retrospective and prospective studies of the specific features of the disease in 94 patients with primary NHL of the organ of...

  12. Systematic search and review procedures: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis

    DEFF Research Database (Denmark)

    Cancelliere, C.; Cassidy, J. D.; Li, A.;

    2014-01-01

    OBJECTIVES: To update the last best-evidence synthesis conducted by the World Health Organization Collaborating Centre for Neurotrauma, Prevention, Management and Rehabilitation in 2002; and to describe the course, identify prognostic factors, determine long-term sequelae, identify effects of....../exclusion criteria. Studies had to have at least 30 MTBI cases and assess outcomes relevant to prognosis after MTBI. DATA EXTRACTION: Eligible studies were critically appraised using modified Scottish Intercollegiate Guidelines Network (SIGN) criteria. Two reviewers independently reviewed each study and extracted...... organized into 10 articles in this supplement. These reviews present the best available evidence on MTBI prognosis, but more research is needed....

  13. Oncoprotein MDM2 Overexpression is Associated with Poor Prognosis in Distinct Non-Hodgkin's Lymphoma Entities

    DEFF Research Database (Denmark)

    Møller, Michael Boe; Nielsen, O; Pedersen, Niels Tinggaard

    1999-01-01

    altered p53. In univariate analysis MDM2 overexpression associated with short survival in follicle center lymphomas (P = .0256), extranodal marginal zone lymphomas (P < .0001), and mantle cell lymphomas (P = .0047). The relation to poor prognosis was maintained in a Cox regression analysis including known...... prognostic factors (relative risk 5.5, P = .0022). The results of the present study suggest that MDM2 may play a role in lymphomagenesis and lymphoma progression through p53-independent mechanisms, and that MDM2 overexpression identifies a small fraction of follicle center lymphomas, extranodal marginal zone...... lymphomas, and mantle cell lymphomas with poor prognosis....

  14. 热射病部队与地方患者临床特点比较及预后影响因素%Comparison on heat stroke’s clinical characteristics between military personnel and local patients and the factors on prognosis

    Institute of Scientific and Technical Information of China (English)

    安芳; 程晨; 王静

    2014-01-01

    Objective To analyze the clinica characteristics and laboratory data of the military and civilian heat stroke patients. Methods The clinical data of 68 hospitalized heat stroke patients, 21 soldiers and 47 local residents, were analyzed. In addition, multivariate logistic regression analyzis was adopted to identify the influential factors on their prognosis. Results Comparing with the local patients, the military patients carried the following characteristics, younger age, shorter time of disease, and higher serum sodium levels (respectively, t=6.15, 2.90, 3.39, all P<0.01). After co-variation adjustment with multivariable logistic regression analysis, D-dimer, serum sodium, creatinine and blood lactate were independent factors to the heat stroke’s in-hospital mortality. Conclusion D-dimer, serum sodium, creatinine and blood lactatee lever are the independent factors to indicate prognosis.%目的:回顾性分析热射病部队患者和地方患者发病临床特点、血液系统损害的不同,并分析其预后的影响因素。方法住院的68例热射病患者,按其来源不同,分为部队患者组21例,地方患者组47例。比较两组患者临床特点和血液学检查结果,并采用多变量Logistic回归分析其病死率的影响因素。结果与地方组比较,部队组患者年龄较轻,发病时间较短,血钠水平偏高,差异有统计学意义(t分别为6.15、2.90、3.39,均P<0.01)。对影响热射病患者住院病死率的危险因素作多变量Logistic回归分析后,发现入院时D二聚体、血钠、Cr及乳酸水平为影响预后的独立预测因素。结论血浆D二聚体、血Cr、乳酸及血钠水平可作为判断预后的指标,重视院外急救、早期监测血液学指标,并采取相应的治疗措施,可降低患者死亡率。

  15. CDC Wonder Vaccine Adverse Event Reporting System

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Vaccine Adverse Event Reporting System (VAERS) online database on CDC WONDER provides counts and percentages of adverse event case reports after vaccination,...

  16. [Treatments with immunoglobulin and thrombotic adverse events].

    Science.gov (United States)

    Darnige, L; Lillo-Le Louët, A

    2014-01-01

    Treatments with intravenous or subcutaneous immunoglobulin (Ig) are used in a broad variety of disorders. Tolerance of Ig is usually good but adverse events, including some serious ones, have been reported and may differ among different Ig preparations. Thrombotic complications occur in 0.6 to 13% of cases and can involve arterial or venous circulation, rarely both. Deep venous thrombosis with or without pulmonary embolism, stroke or myocardial infarction remained the most frequent thrombotic complications. Some risk factors have been identified, mainly old age, multiple cardiovascular risk factors, and past history of thrombo-embolic manifestations. Several mechanisms are suggested to explain this increased risk of thrombotic complications. Indeed, Ig treatments increase the plasma viscosity, increase and activate platelets, can trigger the coagulation cascade through the presence of activated factor XI in some Ig preparations, and release vasoactive molecules responsible for vasospasm. Patients have to be carefully monitored and risk factors to be identified as soon as possible. The role of antiplatelets or anticoagulation is not well determined but should probably be proposed to patients with high risk. PMID:24011913

  17. 祥云县已婚育龄夫妇不良妊娠结局相关因素病例对照研究%A case -control study of related factors of adverse pregnancy outcome among the married couples at childbearing age in Xiangyun county

    Institute of Scientific and Technical Information of China (English)

    宗琳芳; 周梅; 叶汉风; 袁彦玲; 龚晓洁; 李根瑞

    2012-01-01

    目的:探讨已婚育龄夫妇不良妊娠结局发生的危险因素,为制定干预措施、实现优生优育提供依据.方法:随机选取67例不良妊娠结局已婚育龄夫妇,按照1∶1配对的原则选取67例正常妊娠结局的已婚育龄夫妇作对照,调查可能对两组已婚育龄夫妇不良妊娠结局有影响的相关因素,采用SPSS软件对所有调查因素进行单因素与多因素Logistic回归分析.结果:经Logistic回归模型进行单因素分析,有统计学意义的危险因素有已婚育龄夫妇的年龄(女:OR值=0.585,男:OR值=0.536)、受教育年限(女:OR值=2.982,男:OR值=2.811)、已婚育龄妇女是否曾经怀孕过(包括曾经非意愿流产、早产、不良妊娠结局以及正常分娩等,OR值=2.210)、丈夫的体重指数(OR值=0.370)、丈夫是否吸烟(OR值=11.400)以及丈夫现在是否戒烟(OR值=0.098).经Logistic回归模型进行多因素分析,有统计学意义的危险因素有丈夫是否吸烟(OR值=8.313)、丈夫是否戒烟(OR值=0.082).结论:已婚育龄夫妇的年龄、受教育年限、已婚育龄妇女是否曾经怀孕过(包括曾经非意愿流产、早产、不良妊娠结局以及正常分娩等)、丈夫的体重指数等均为不良妊娠结局的危险因素,并且再次证实了吸烟对不良妊娠结局的影响.劝阻丈夫吸烟、减少育龄妇女被动吸烟、控制婚育年龄、避免高龄妊娠、合理饮食以避免过重和肥胖均能够减少不良妊娠结局的发生.%Objective: To explore the risk factors of adverse pregnancy outcome among the married couples at childbearing age, provide a basis for making interventional measures and realizing prepotency. Methods: Sixty - seven married cases at childbearing age with adverse pregnancy outcome were selected randomly, then 67 married cases at childbearing age with normal pregnancy outcome were selected as control group according to 1: 1 matched principle. The related effect factors of adverse

  18. Obesity and Prevalence of Cardiovascular Diseases and Prognosis-The Obesity Paradox Updated.

    Science.gov (United States)

    Lavie, Carl J; De Schutter, Alban; Parto, Parham; Jahangir, Eiman; Kokkinos, Peter; Ortega, Francisco B; Arena, Ross; Milani, Richard V

    2016-01-01

    The prevalence and severity of obesity have increased in the United States and most of the Westernized World over recent decades, reaching worldwide epidemics. Since obesity worsens most of the cardiovascular disease (CVD) risk factors, not surprisingly, most CVDs, including hypertension, coronary heart disease, heart failure, and atrial fibrillation, are all increased in the setting of obesity. However, many studies and meta-analyses have demonstrated an obesity paradox with regards to prognosis in CVD patients, with often the overweight and mildly obese having a better prognosis than do their leaner counterparts with the same CVD. The implication for fitness to markedly alter the relationship between adiposity and prognosis and the potential impact of weight loss, in light of the obesity paradox, are all reviewed. PMID:26826295

  19. Correlation of plasma catestatin level and the prognosis of patients with acute myocardial infarction.

    Directory of Open Access Journals (Sweden)

    Dan Zhu

    Full Text Available Catestatin is a peptide which is a potent inhibitor of catecholamine secretion and played essential functions in the cardiovascular system. Previous research found that dramatic changes of catestatin were associated with hemodynamics in acute myocardial infarction (AMI during the first week after the AMI symptoms onset, but whether catestatin is also involved in the pathophysiological progression after AMI and then a predictor for outcomes is not clear. The aim of this study is to determine the correlation of plasma catestatin levels at different time points and the prognosis of AMI. 100 participants recruited were all patients with AMI, all of who received successful primary percutaneous coronary intervention (PCI within 12h from the AMI symptom onset in our center; the concentrations of plasma catestatin were evaluated from blood samples of those 100 participants. Subsequent 65 months' follow-up was performed after discharging to evaluate cardiac adverse events and the association between catestatin levels and prognosis of AMI was examined. We confirmed the dramatic change of catestatin concentrations in the first week of AMI, and the levels of catestatin on D3 were much higher in adverse events group than those in non-adverse events group (p<0.0001, but the ratio of D7/D3 was significantly lower. In addition, the Kaplan-Meier analysis showed that the groups in which the levels on D3 were higher (p<0.0001 and the ratios of D7/D3 were lower (p<0.0001, patients trended to be more susceptive to adverse events after AMI. Furthermore, according to the analysis, we surmised catestatin level on D3 as an appropriate predictor for outcomes in patients with AMI with good specificity as well as sensitivity. All of the evidence confirmed that catestatin plays an important role in the progress of AMI, and may act as a promising target for prognostic prediction.

  20. Childhood adversities in relation to psychiatric disorders

    OpenAIRE

    Pietrek, Christian; Elbert, Thomas; Weierstall, Roland; Müller, Oliver; Rockstroh, Brigitte

    2013-01-01

    Substantial evidence has documented that adverse childhood experiences exert deleterious effects on mental health. It is less clear to what extent specific maltreatment during specific developmental periods may vary between disorders rather than increasing vulnerability for any particular disorder. The present comparison of characteristics of childhood adversity (type and frequency of adversity, developmental period) between major depressive disorder (MDD), borderline personality disorder (BP...

  1. Accident Diagnosis and Prognosis Aide (ADPA)

    International Nuclear Information System (INIS)

    This presentation provides a demonstration of a prototypical expert system developed by Technology Applications, Inc. (TAI) under a contract with the Department of Energy as a part of their Small Business Innovation Research Program. The Accident Diagnosis and Prognosis Aide (ADPA) Demonstration Prototype is a working scale model of a real-time expert system which: Diagnoses an accident situation (as well as a number of underlying failures, events, and conditions deduced along the way). Calculates the change in the likelihood of core damage as a function of the events and failures diagnosed. Dynamically generates a recovery procedure tailored to the specific plant state at hand

  2. Sleep impairment and prognosis of acute myocardial infarction

    DEFF Research Database (Denmark)

    Clark, Alice; Lange, Theis; Hallqvist, Johan;

    2014-01-01

    STUDY OBJECTIVES: Impaired sleep is an established risk factor for the development of cardiovascular disease, whereas less is known about how impaired sleep affects cardiovascular prognosis. The aim of this study is to determine how different aspects of impaired sleep affect the risk of case...... fatality and subsequent cardiovascular events following first-time acute myocardial infarction (AMI). DESIGN: Prospective cohort study. SETTING: The Stockholm Heart Epidemiology Program, Sweden. PARTICIPANTS: There were 2,246 first-time AMI cases. MEASUREMENTS AND RESULTS: SLEEP IMPAIRMENT WAS ASSESSED BY...... THE KAROLINA SLEEP QUESTIONNAIRE, WHICH COVERS VARIOUS INDICES OF IMPAIRED SLEEP: disturbed sleep, impaired awakening, daytime sleepiness, and nightmares. Case fatality, defined as death within 28 days of initial AMI, and new cardiovascular events within up to 10 y of follow-up were identified through...

  3. Prognosis of patients with whiplash-associated disorders consulting physiotherapy

    DEFF Research Database (Denmark)

    Bohman, Tony; Côté, Pierre; Boyle, Eleanor;

    2012-01-01

    BACKGROUND: Patients with whiplash-associated disorders (WAD) have a generally favourable prognosis, yet some develop longstanding pain and disability. Predicting who will recover from WAD shortly after a traffic collision is very challenging for health care providers such as physical therapists....... Therefore, we aimed to develop a prediction model for the recovery of WAD in a cohort of patients who consulted physical therapists within six weeks after the injury. METHODS: Our cohort included 680 adult patients with WAD who were injured in Saskatchewan, Canada, between 1997 and 1999. All patients had...... consulted a physical therapist as a result of the injury. Baseline prognostic factors were collected from an injury questionnaire administered by Saskatchewan Government Insurance. The outcome, global self-perceived recovery, was assessed by telephone interviews six weeks, three and six months later. Twenty...

  4. Adverse events in healthcare: learning from mistakes.

    Science.gov (United States)

    Rafter, N; Hickey, A; Condell, S; Conroy, R; O'Connor, P; Vaughan, D; Williams, D

    2015-04-01

    Large national reviews of patient charts estimate that approximately 10% of hospital admissions are associated with an adverse event (defined as an injury resulting in prolonged hospitalization, disability or death, caused by healthcare management). Apart from having a significant impact on patient morbidity and mortality, adverse events also result in increased healthcare costs due to longer hospital stays. Furthermore, a substantial proportion of adverse events are preventable. Through identifying the nature and rate of adverse events, initiatives to improve care can be developed. A variety of methods exist to gather adverse event data both retrospectively and prospectively but these do not necessarily capture the same events and there is variability in the definition of an adverse event. For example, hospital incident reporting collects only a very small fraction of the adverse events found in retrospective chart reviews. Until there are systematic methods to identify adverse events, progress in patient safety cannot be reliably measured. This review aims to discuss the need for a safety culture that can learn from adverse events, describe ways to measure adverse events, and comment on why current adverse event monitoring is unable to demonstrate trends in patient safety. PMID:25078411

  5. Early infection and prognosis after acute stroke

    DEFF Research Database (Denmark)

    Kammersgaard, L P; Jørgensen, H S; Reith, J;

    2001-01-01

    Infection is a frequent complication in the early course of acute stroke and may adversely affect stroke outcome. In the present study, we investigate early infection developing in patients within 3 days of admission to the hospital and its independent relation to recovery and stroke outcome. In...... addition, we identify predictors for early infections, infection subtypes, and their relation to initial stroke severity....

  6. Factoring

    OpenAIRE

    Lenstra, Arjen K.

    1994-01-01

    Factoring, finding a non-trivial factorization of a composite positive integer, is believed to be a hard problem. How hard we think it is, however, changes almost on a daily basis. Predicting how hard factoring will be in the future, an important issue for cryptographic applications of composite numbers, is therefore a challenging task. The author presents a brief survey of general purpose integer factoring algorithms and their implementations

  7. Clinicopathological characteristics and prognosis of early gastric cancer after gastrectomy

    Institute of Scientific and Technical Information of China (English)

    WANG Yong-xiang; SHAO Qin-shu; YANG Qiong; WANG Yuan-yu; YANG Jin; ZHAO Zhong-kuo; XU Ji; YE Zai-yuan

    2012-01-01

    Background Assessment of lymph node metastasis (LNM) is important in early gastric cancer (EGC) and affects treatment decisions.However,the relationship between clinicopathological characteristics and LNM in EGC remains unclear.This study therefore explored favorable predictors of LNM in EGC.Methods A total of 716 specimens from gastric cancer patients who underwent curative gastrectomy between 1996 and 2003 at Zhejiang Provincial People's Hospital were reviewed.Forty-five cases were EGC,and clinicopathological characteristics such as gender,age,tumor size,location,gross type,differentiation,invasion depth,and vessel involvement were assessed to identify predictive factors for LNM and survival time.Results The overall cumulative 5-year survival rate of EGC patients was 88.92%.Among these,22.4% developed LNM,which was associated with a poor 5-year survival rate of only 72.7%.Patients with tumors larger than 2 cm in diameters,with depth of tumor invasion to the submucosa,and with positive lymphatic or nerve involvement were also inclined to have poorer survival performances.EGC limited to the mucosa but poorly differentiated also had a high risk for LNM.Multivariate analysis identified lymphatic invasion and tumor size as independent prognosis factors related to survival in EGC patients.Conclusions Careful planning is required in EGC patients at high risk of lymph node metastases.Endoscopic mucosal resection or endoscopic submucosal dissection and laparoscopic partial gastrectomy should be cautiously used in EGC,and curative gastrectomy including lymphatic dissection and postoperative adjuvant therapy might be considered to improve the prognosis.

  8. Relationship between the prognosis of interstitial pneumonia and its comorbidities

    International Nuclear Information System (INIS)

    To investigate the relationship between the prognosis of chronic interstitial pneumonia (IP) and its comorbidities, we conducted a retrospective study for clinically and radiologically diagnosed IP. We assessed comorbidities by using the Charlson Comorbidity Index (CCI). We classified 224 patients given clinical diagnoses of chronic IP (excluding the patients who had clear causes such as collagen disease, infection, drugs or radiation) in our institution between April 2000 and June 2010, into 2 groups; those with clinical diagnoses of idiopathic pulmonary fibrosis (IPF: 108 cases) and those with other chronic IP but without honeycomb lung (116 cases); and analyzed their backgrounds and comorbidities. We also classified them into survival and non-survival groups to assess their prognostic factors. Although the smoking status of patients with clinically diagnosed IPF was higher, and SpO2 was lower than those with other chronic IP without honeycomb lung, the mean age, comorbidities and CCI did not differ between them. The 5-year overall survival of the clinically-diagnosed IPF group was lower than that of the other chronic IP without honeycomb lung group (50.8% vs. 76.3%, p<0.01). In cases of other chronic IP without honeycomb lung, the CCI of non-survival cases was higher than that of survival cases (4.05 vs. 2.47, p<0.01), although patient backgrounds did not differ between survival and non-survival cases in those with clinically diagnosed IPF (CCI: 2.32 vs. 2.98, p=0.70). Our analysis revealed the possibility that comorbidities and CCI were prognostic factors in other chronic IP cases without honeycomb lung, although the prognosis of IPF was not affected by their comorbidity. (author)

  9. Psychological problems affecting the prognosis of stroke patients

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND:It is believed that mental disorder influences the morbility and prognosis of cardio-cerebrovascular disease by biological factors.OBJECTIVE:To observe the characteristics of stroke patients complicated by psychological problems and the prognosis of such patients.DESIGN:Observational study.SETTING:Department of Neurology,Beijing Longfu Hospital.PARTICIPANTS:Totally 160 inpatients (46 males and 114 females) with stroke admitted to Department of Neurology,Beijing Longfu Hospital between June 2005 and June 2006 were recruited in this study.The involved patients all corresponded to the diagnosis criteria of cerebrovascular disease formulated in the 1995 National Conference of Cerebrovascular Disease and confirmed by skull CT or MRI examination.The age range was between 43 and 74 years.They all signed the informed consent for the detection and therapeutic regimen,and the application of this technique also gave the approval of the Ethics Committee of the hospital.METHODS:On admission,the patients were investigated on psychological problems using Hopkin symptom checklist.After admission,all the patients received oral administration of aspirin anti-platelet drugs and intravenous infusion of Fufang Danshen.Motor relearning program was used in the rehabilitation treatment for disability rehabilitation.Mental intervention was carried out in the end of observation period.On day 30 after admission,the recovery of two groups of patients was compared using activities of daily living scale,Scandinanvian Stroke Scale (SSS) and disability level.MAIN OUTCOME MEASURES:The activities of daily living were assessed with Barthel index.Higher scores of patients suggested better activities of daily living.For SSS,the higher points,the severer defect degree.The reduction of scores of neurologic impairment suggested that neurological function improved.Disability level was graded according to the method formulated in the Second National Cerebrovascular Conference.RESULTS:All the 160

  10. The Risk Factors for Criminal Behaviour in High-Functioning Autism Spectrum Disorders (HFASDs): A Comparison of Childhood Adversities between Individuals with HFASDs Who Exhibit Criminal Behaviour and Those with HFASD and No Criminal Histories

    Science.gov (United States)

    Kawakami, Chihiro; Ohnishi, Masafumi; Sugiyama, Toshiro; Someki, Fumio; Nakamura, Kazuhiko; Tsujii, Masatsugu

    2012-01-01

    Most reports of the criminal behaviour of individuals with high-functioning autism spectrum disorder (HFASD) have been case studies, and few have empirically examined the risk factors of criminal behaviour among these individuals. This study examined 175 individuals with HFASD, including 36 individuals who had a prior history of criminal…

  11. Mediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: a randomized controlled trial in a high-cardiovascular-risk population

    Science.gov (United States)

    Transcription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) on these associations are unknown. We investigated whether the TCF7L2-rs7903146 (C>T)...

  12. Serious adverse events associated with yellow fever vaccine

    OpenAIRE

    de Menezes Martins, Reinaldo; da Luz Fernandes Leal, Maria; Homma, Akira

    2015-01-01

    Yellow fever vaccine was considered one of the safest vaccines, but in recent years it was found that it could rarely cause invasive and disseminated disease in some otherwise healthy individuals, with high lethality. After extensive studies, although some risk factors have been identified, the real cause of causes of this serious adverse event are largely unknown, but findings point to individual host factors. Meningoencephalitis, once considered to happen only in children less than 6 months...

  13. Medical adverse events in elderly hospitalized patients: a prospective study

    Directory of Open Access Journals (Sweden)

    Claudia Szlejf

    2012-11-01

    Full Text Available OBJECTIVES: To determine the frequency of medical adverse events in elderly patients admitted to an acute care geriatric unit, the predictive factors of occurrence, and the correlation between adverse events and hospital mortality rates. METHODS: This prospective study included 171 admissions of patients aged 60 years and older in the acute care geriatric unit in a teaching hospital in Brazil between 2007 and 2008. The following variables were assessed at admission: the patient age, gender, number of prescription drugs, geriatric syndromes (e.g., immobility, postural instability, dementia, depression, delirium, and incontinence, comorbidities, functional status (evaluated with the Katz Index of Independence in Activities of Daily Living, and severity of illness (evaluated with the Simplified Acute Physiology Score Il. The incidence of delirium, infection, mortality, and the prescription of potentially inappropriate medications (based on the Beers criteria were assessed during hospitalization. An observer who was uninvolved in patient care reported the adverse events. RESULTS: The mean age of the sample was 78.12 years. A total of 187 medical adverse events occurred in 94 admissions (55%. The predictors of medical adverse events were undetermined. Compared with the patients with no adverse events, the patients with medical adverse events had a significantly longer hospital stay (21.41 ± 15.08 days versus 10.91 ± 7.21 days and a higher mortality rate (39 deaths [41.5%] versus 17 deaths [22.1%]. Mortality was significantly predicted by the Simplified Acute Physiology Score II score (odds ratio [OR] = 1.13, confidence interval [CI] 95%, 1.07 to 1.20, the Katz score (OR=1.47, CI 95%, 1.18 to 1.83, and medical adverse events (OR = 3.59, CI 95%, 1.55 to 8.30. CONCLUSION: Medical adverse events should be monitored in every elderly hospitalized patient because there is no risk profile for susceptible patients, and the consequences of adverse events are

  14. Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital

    OpenAIRE

    Fabiana Rossi Varallo; Helaine Carneiro Capucho; Cleópatra da Silva Planeta; Patrícia de Carvalho Mastroianni

    2014-01-01

    OBJECTIVES: Drug safety problems can lead to hospital admission. In Brazil, the prevalence of hospitalization due to adverse drug events is unknown. This study aims to estimate the prevalence of hospitalization due to adverse drug events and to identify the drugs, the adverse drug events, and the risk factors associated with hospital admissions. METHOD: A cross-sectional study was performed in the internal medicine ward of a teaching hospital in São Paulo State, Brazil, from August to Decemb...

  15. Study and evaluation of the various cutaneous adverse drug reactions in Kasturba hospital, Manipal

    OpenAIRE

    Ghosh S; Acharya Leelavathi; Rao Padma

    2006-01-01

    The present study emphasizes on implementation of the adverse drug reaction reporting and monitoring system, in the Dermatology department of Kasturba Hospital, Manipal, by a clinical pharmacist, using different promotional activities. Documented adverse drug reactions were assessed and analyzed for incidence, purpose of visit, types, drug classes, individual drug causing adverse drug reactions, type of cutaneous reaction, and various predisposing factors. Management and outcome of the advers...

  16. A large-scale survey of adverse events experienced in yoga classes

    OpenAIRE

    Matsushita, Tomoko; Oka, Takakazu

    2015-01-01

    Background Yoga is a representative mind-body therapy of complementary and alternative medicine. In Japan, yoga is practiced widely to promote health, but yoga-associated adverse events have also been reported. To date, the frequencies and characteristics of yoga-related adverse events have not been elucidated. This study was conducted to elucidate the frequencies and characteristics of adverse events of yoga performed in classes and the risk factors of such events. Methods The subjects were ...

  17. Adverse effects of IgG therapy.

    Science.gov (United States)

    Berger, Melvin

    2013-01-01

    IgG is widely used for patients with immune deficiencies and in a broad range of autoimmune and inflammatory disorders. Up to 40% of intravenous infusions of IgG may be associated with adverse effects (AEs), which are mostly uncomfortable or unpleasant but often are not serious. The most common infusion-related AE is headache. More serious reactions, including true anaphylaxis and anaphylactoid reactions, occur less frequently. Most reactions are related to the rate of infusion and can be prevented or treated just by slowing the infusion rate. Medications such as nonsteroidal anti-inflammatory drugs, antihistamines, or corticosteroids also may be helpful in preventing or treating these common AEs. IgA deficiency with the potential of IgG or IgE antibodies against IgA increases the risk of some AEs but should not be viewed as a contraindication if IgG therapy is needed. Potentially serious AEs include renal dysfunction and/or failure, thromboembolic events, and acute hemolysis. These events usually are multifactorial, related to combinations of constituents in the IgG product as well as risk factors for the recipient. Awareness of these factors should allow minimization of the risks and consequences of these AEs. Subcutaneous IgG is absorbed more slowly into the circulation and has a lower incidence of AEs, but awareness and diligence are necessary whenever IgG is administered. PMID:24565701

  18. Supplementation prevalence and adverse effects in physical exercise practitioners

    Directory of Open Access Journals (Sweden)

    Walkiria Valeriano da Silva

    2014-01-01

    Full Text Available Introduction: The use of nutritional supplements is prevalent among physical exercise practitioners and some adverse effects have been reported, however not sufficiently substantial, because they originate from isolated cases. Objectives: Investigate nutritional supplements consumption prevalence and adverse effects of the use of such products. Methods: An epidemiological, representative and transversal study, with 180 physical exercise practitioners in gyms, who answered questionnaires about sports supplementation, associated factors and self-perceived adverse effects. In a subsample of 86 individuals, blood pressure was measured and blood was collected for the evaluation of lipid profile markers, hepatic and renal function. Results: The supplementation prevalence level was 58.3%, whereas the physicians and nutritionists indicated only 21.9%. The reported adverse effects were observed only by supplement users (acne, insomnia, aggressiveness, headaches and tachycardia. Systolic blood pressure was higher in the supplemented group when compared to the control group (p = 0.04, as in the subgroup of thermogenic users (p < 0.0001 and among those who had consumed any type of supplementation for over 2 years (p = 0.005. Serum creatinine levels were higher only in the subgroup of carbohydrates when compared to the control group (p = 0.03. Diastolic blood pressure, lipid profile and hepatic function did not present differences between groups. Conclusions: The use of nutritional supplements without specialized orientation was elevated among physical exercise practitioners, being associated to adverse effects both by the users themselves and by clinical diagnosis.

  19. The epidemiology of disasters and adverse reproductive outcomes: lessons learned.

    Science.gov (United States)

    Cordero, J F

    1993-07-01

    A disaster has been defined as a disruption of human ecology that exceeds the capacity of the community to function normally. Little is known about the adverse effects of natural disasters on reproductive outcomes. Important lessons can be derived from several disasters caused by human factors, such as the Minamata Bay disaster. Adverse reproductive outcomes include infertility, early pregnancy loss, stillbirths, congenital malformations, and serious developmental disabilities such as cerebral palsy and mental retardation. Recent disasters like the Chernobyl and Bhopal explosions have provided important lessons on the need for accurate and sound information about the risk of prenatal exposures for adverse reproductive outcomes. To study questions of adverse reproductive outcomes and disasters requires a well-planned approach. It should include early development of surveillance for adverse reproductive outcomes, analytic studies on the risk of disasters from direct and indirect effects, sensitive methods to measure early pregnancy loss, and long-term follow-up programs to assess outcomes such as developmental disabilities. PMID:8243383

  20. Analysis of etiologic type,risk factors and prognosis of 162 young patients with cerebral in-farction%162例青年脑梗死患者病因分型、危险因素及预后分析

    Institute of Scientific and Technical Information of China (English)

    林文

    2015-01-01

    目的:探讨青年脑梗死的病因分型、危险因素及预后。方法回顾性分析162例急性青年脑梗死患者的临床资料,采用 Logistic 回归分析其主要危险因素。结果本组患者病因分型构成为大动脉粥样硬化型38例(占23.5%),心源性型20例(占12.3%),小动脉病变型28例(占17.3%),其他原因型12例(占7.4%),原因不明型64例(占39.5%)。可能的危险因素所占构成比为:高血压病51.2%(83/162)、吸烟34.6%(56/162),高脂血症28.4%(46/162),饮酒25.3%(41/162),心脏疾病13.6%(22/162),糖尿病11.1%(18/162)。 Logistic 回归分析提示高血压、吸烟、高脂血症、饮酒是青年脑梗死的危险因素。162例患者中81例完全恢复,56例遗留较轻的后遗症,22例遗留严重后遗症,3例急性期死亡。结论青年脑梗死的病因分型以原因不明型和大动脉粥样硬化性型所占比例较高。危险因素为高血压病、吸烟、高脂血症和饮酒。%Objective To analyze the etiology,risk factors and prognosis in young patients with cerebral infarction .Methods Clinical data of 162 young patients at the first attack of acute cerebral infarction were analyzed .Logistic regression analysis was used to analyze the major risk factors.Results According to TOAST typing,there were 38 cases with large artery atherosclerotic infarction (23.5%),28 with small artery cerebral infarction (17.3%),20 with cardiogenic cerebral embolism (12.3%),12 with cerebral infarc-tion of other causes (7.4%) and 64 with unknown origin (39.5%).The possible risk factors were hypertension (83 /162 cases, 51.2%),smoking (56 /162 cases,34.6%),blood lipid abnormality(46 /162 cases 28.4%) and alcohol consumption (41 /162 cases, 25.3%),heart disease (22 cases,13.6%) and diabetes mellitus (18 /162 cases,11.1%).Logistic regression analysis showed that hypertension

  1. Clinicopathologic and gene expression parameters predict liver cancer prognosis

    International Nuclear Information System (INIS)

    The prognosis of hepatocellular carcinoma (HCC) varies following surgical resection and the large variation remains largely unexplained. Studies have revealed the ability of clinicopathologic parameters and gene expression to predict HCC prognosis. However, there has been little systematic effort to compare the performance of these two types of predictors or combine them in a comprehensive model. Tumor and adjacent non-tumor liver tissues were collected from 272 ethnic Chinese HCC patients who received curative surgery. We combined clinicopathologic parameters and gene expression data (from both tissue types) in predicting HCC prognosis. Cross-validation and independent studies were employed to assess prediction. HCC prognosis was significantly associated with six clinicopathologic parameters, which can partition the patients into good- and poor-prognosis groups. Within each group, gene expression data further divide patients into distinct prognostic subgroups. Our predictive genes significantly overlap with previously published gene sets predictive of prognosis. Moreover, the predictive genes were enriched for genes that underwent normal-to-tumor gene network transformation. Previously documented liver eSNPs underlying the HCC predictive gene signatures were enriched for SNPs that associated with HCC prognosis, providing support that these genes are involved in key processes of tumorigenesis. When applied individually, clinicopathologic parameters and gene expression offered similar predictive power for HCC prognosis. In contrast, a combination of the two types of data dramatically improved the power to predict HCC prognosis. Our results also provided a framework for understanding the impact of gene expression on the processes of tumorigenesis and clinical outcome

  2. 乙酰肝素酶、碱性成纤维细胞生长因子的表达与子宫内膜癌浸润、转移及预后的关系%Relationship between expressions of heparanase and basic fibroblast growth factor and invasion, metastasis and prognosis of endometrial carcinoma

    Institute of Scientific and Technical Information of China (English)

    毕冬华

    2012-01-01

    目的:探讨乙酰肝素酶、碱性成纤维细胞生长因子的表达与子宫内膜癌浸润、转移及预后的关系.方法:选择2008年3月~2010年10月期间,在该院切除并存档的子宫内膜癌患者子宫内膜石蜡包埋组织标本48例作为研究组,另选同期该院妇产科收治的其他疾病患者,手术切除或刮宫的子宫内膜标本34例作为比较组,及正常子宫内膜21例作为对照组,分别比较分析Hpa和bFGF的染色强度及表达阳性率.结果:与FIGO Ⅰ期相比,Ⅱ期和Ⅲ期患者Hpa和bFGF的阳性率明显提高;与G1分化相比,G2分化患者Hpa和bFGF的阳性率明显提高;与无肌层浸润相比,肌层浸润浅部和深部患者Hpa和bFGF的阳性率明显提高,差异均具有统计学意义(P<0.05);与对照组患者相比,比较组患者和研究组患者的Hpa和bFGF阳性率均明显提高,差异均具有统计学意义(P<0.05),且研究组的阳性率高于比较组.结论:乙酰肝素酶和碱性成纤维细胞生长因子的表达与子宫内膜癌浸润、转移、预后密切相关,并且有望成为子宫内膜癌联合诊断和病情评估以及疗效观察和预后预测的重要检测指标,同时也可能为子宫内膜癌的治疗提供一种更为有效的解决方案.%Objective; To explore the relationship between expressions of heparanase (Hpa) and basic fibroblast growth factor ( bF-GF) and invasion, metastasis and prognosis of endometrial cancer. Methods: Four - eight paraffin - embeded endometrial samples from the patients with endometrial cancer who received surgery and were recorded in the hospital from March 2008 to October 2010 were selected as study group, while 34 paraffin -embeded endometrial samples from the patients with other endometrial diseases who received surgery and u-terine curettage in the hospital during the same period were selected as comparison group, 21 normal paraffin - embeded endometrial samples were selected as control group; the staining

  3. Pharmacogenomics and adverse drug reactions in children

    OpenAIRE

    Rieder, Michael J; Carleton, Bruce

    2014-01-01

    Adverse drug reactions are a common and important complication of drug therapy in children. Over the past decade it has become increasingly apparent that genetically controlled variations in drug disposition and response are important determinants of adverse events for many important adverse events associated with drug therapy in children. While this research has been difficult to conduct over the past decade technical and ethical evolution has greatly facilitated the ability of investigators...

  4. PENGARUH ADVERSITY QUOTIENT TERHADAP INTENSI BERWIRAUSAHA

    OpenAIRE

    Zahreni, Siti; Pane, Ratna Sari Dewi

    2012-01-01

    The objective of this study is to know the influence of Adversity Quotienton entrepreneurial intention og college students. This research involves 80 college students from faculty of psychology Universitas Sumatera Utara with sampling technique using convinience sampling. Data obtained processed using Simple linear regression analysis. the measuring instrument used is the scale of entrepreneurial intention and the scale of adversity quotient. Result showed that Adversity Quotient significantl...

  5. Analysis of Related Factors of Adverse Drug Reaction Occurred in the Methadone Maintenance Treatment%美沙酮药物维持治疗中药品不良反应事件发生的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    李群

    2014-01-01

    目的:分析美沙酮药物维持治疗中药品不良反应事件发生的相关因素。方法:回顾性分析我院2011年8月~2013年6月收治的100例接受美沙酮药物维持治疗的海洛因成瘾者的临床资料。结果:美沙酮维持治疗引入期和维持期出现的不良反应发生率最高的是便秘,分别占总数的60%和71%;不同既往海洛因用量的患者的便秘发生率相比具有显著的统计学差异(P0.05)。结论:美沙酮药物维持治疗中药品不良反应事件发生的相关因素有既往海洛因滥用量、美沙酮用药时间及维持剂量等,临床应给予这些因素以充分重视。%To analyze the related factors of adverse drug reaction occurred in the methadone maintenance treatment. Methods:A retrospective analysis of the clinical data of methadone maintenance treatment of drug addicts in our hospital in 2011 August to 2013 June were treated 100 cases.Results:The adverse reaction of methadone maintenance treatment is introduced and maintenance period is the highest rate of constipation,accounted for 60%and 71%respectively;the different amount of heroin patients the incidence of constipation compared with significant statistical difference (P0.05).Conclusion:Methadone maintenance treatment of drug related factors of adverse drug reaction occurred with the heroin abuse dosage,time of methadone administration and maintenance dose,clinical should give full attention to these factors.

  6. 微创玻璃体切割术治疗特发性黄斑前膜视力预后影响因素分析%Prognosis factors analysis of micro-invasive vitrectomy for idiopathic epiretinal macular membranes

    Institute of Scientific and Technical Information of China (English)

    李聪慧; 孙吉君; 刘文; 任增金; 宋宗明

    2013-01-01

    Objective To investigate the postoperative vision in idiopathic epiretinal macular membranes (IEM),and its influencing factors.Methods A retrospective interventional case series of 76 eyes in 68 patients with IEM.All patients underwent micro-invasive vitrectomy with peeling off of the epiretinal macular membrane.All the patients had underwent the examinations of best corrected visual acuity (BCVA),slit lamp microscope,direct ophthalmoscope,binocular indirect ophthalmoscope,optical coherence tomography (OCT) and underwent 3-port pars plana vitrectomy using 23-guage instrumentation and 25-gauge infusion.Follow-up duration varied from 6 to 36 months,with the mean of (6.9+4.3) months.The multiple factors related with age,course,preoperative best-corrected visual acuity (BCVA),preoperative mean central macular thickness (CMT),internal limit membrane peeling technique,triamcinolone-assisted internal limiting membrane peeling technique and the integrity of the IS/OS junction were analyzed.Logistic regression analysis was performed to predict the prognosis of visual acuity.Results The postoperative visual acuity was improved in 52 eyes (68.4%),decreased in 24 eyes (31.6%).No ocular complications such as fundus hemorrhage,low or high intraocular pressure,endophthalmitis were found.The course,preoperative BCVA (r =0.793,P =0.008),preoperative CMT (r =0.979,P =0.011) and the photoreceptor inner and outer segment (IS/OS) junction line continuity (r =1.358,P =0.010) were closely related to visual prognosis.Conclusions The effect of surgery on the treatment of IEM determined by several factors.The course,BCVA,preoperative CMT and photoreceptor defects,were present in patients with IEM.Estimation of those changes may be an important prognostic factor in cases of epiretinal membranes.And the integrity of the IS/OS junction reading is closely related to patients' visual acuity.%目的 探讨特发性黄斑前膜(IEM)患者微创玻璃体切割术后视

  7. Significance of the ratio of plasma vascular endothelial growth factor level to platelet count in the prognosis of patients with sepsis%血浆血管内皮生长因子浓度与血小板计数比值对脓毒症预后的预测作用

    Institute of Scientific and Technical Information of China (English)

    江稳强; 欧阳维富; 陈纯波; 朱高峰; 黄林强; 曾红科

    2014-01-01

    /PLT比值的最佳截断点为1.32时,敏感度为81.0%、特异度为48.8%.结论 VEGF/PLT比值可以预测脓毒症患者28 d的生存情况.%Objective To investigate the clinical value of the ratio of plasma vascular endothelial growth factor level to platelet count (VEGF/PLT) in predicting 28-day prognosis in patients with sepsis.Methods A prospective cohort study was conducted.From September 2009 to March 2013,164 sepsis patients in Intensive Care Unit (ICU) of Guangdong General Hospital were included for study.Patients with age younger than 18 years old,the illness already reaching final stage of chronic diseases,suffering from two or more organs dysfunction within 3 days,acute pancreatitis without infection,or less than 28 days of expected survival time were excluded.Finally,135 patients were included in the further analysis.Peripheral blood samples were collected at admission.Routine blood tests were done,and then VEGF levels in plasma were measured by enzyme linked immunosorbent assay (ELISA).Acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) scores were recorded every day for 7 days.Patients' prognosis was assessed during the following 28 days.The patients were divided into 28-day survival group and non-survival group.Comparison between two groups was done by single factor analysis.Spearman rank correlation was used to analyze the correlation between VEGF levels and PLT.Mutivariate logistic regression analysis was performed to identify the independent risk factor for 28-day prognosis.Receiver operating characteristic curve (ROC curve) was plotted,and the effect of related indexes on predicting 28-day survival was evaluated by area under ROC curve (AUC).Results There were no significant differences in VEGF (ng/L:471.73 ± 198.34 vs.383.49 ± 266.54,t=-1.918,P=0.057),PLT (× 109/L:220.40±127.60 vs.246.42± 100.72,t=1.275,P=0.204),leucocyte counts (× 109/L:12.48 ±4.62 vs.13.70 ±5.97,t=1.063,P=0.292),mean arterial pressure [mmHg (1 mmHg=0

  8. The mTOR Pathway and the Role of Energy Balance Throughout Life in Colorectal Cancer Etiology and Prognosis: Unravelling Mechanisms Through a Multidimensional Molecular Epidemiologic Approach

    OpenAIRE

    Weijenberg, Matty P.; Hughes, Laura A. E.; Bours, Martijn J. L.; Simons, Colinda C. J. M.; van Engeland, Manon; van den Brandt, Piet A.

    2013-01-01

    Timing of exposure to lifestyle factors that influence energy balance may differentially affect colorectal cancer (CRC) risk and prognosis. Caloric restriction in youth and short stature, as markers of early-life exposures, have shown to decrease CRC risk, whereas large body size and low physical activity levels in adulthood are established risk factors for CRC. Regarding prognosis, overweight, sarcopenia, and their co-occurrence (sarcopenic obesity) may negatively influence the health and qu...

  9. Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome?

    DEFF Research Database (Denmark)

    Pinborg, A; Wennerholm, U B; Romundstad, L B; Loft, A; Aittomaki, K; Söderström-Anttila, V; Nygren, K G; Hazekamp, J; Bergh, C

    2013-01-01

    Assisted reproduction technology (ART) is used worldwide, at increasing rates, and data show that some adverse outcomes occur more frequently than following spontaneous conception (SC). Possible explanatory factors for the well-known adverse perinatal outcome in ART singletons were evaluated....

  10. Effect of metabolic syndrome on prognosis and clinical characteristics of revascularization in patients with coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    HU Rong; JIA Chang-qi; LIU Xin-min; DONG Jian-zeng; LIU Xiao-hui; CHEN Fang; ZHOU Yu-jie; L(U) Shu-zheng; WU Xue-si; MA Chang-sheng; NIE Shao-ping; L(U) Qiang; KANG Jun-ping; DU Xin; ZHANG Yin; GAO Ying-chun; HE Li-qun

    2006-01-01

    Background People with metabolic syndrome are at higher risk for developing coronary artery disease (CAD).The effect of the metabolic syndrome on outcomes in patients with preexisting CAD has not been well studied.This study was conducted to assess the prevalence, characteristics, in hospital and long term prognosis of CAD with metabolic syndrome and to determine the factors influencing the prognosis of the disease.Methods The DESIRE registry contains data of 3696 patients with CAD between 2001 and 2004. Mean long term followup was (829±373) days. Diagnosis of metabolic syndrome was based on modified International Diabetes Federation (IDF) Worldwide Definition of the Metabolic Syndrome, using body mass index (BMI)instead of waist circumference.Results Of 2596 patients with complete records of height, weight, and so on, 1280 (49.3%) were identified with metabolic syndrome. The patients with metabolic syndrome had higher level of body mass index, systolic blood pressure, diastolic blood pressure, fasting glucose and disordered blood lipid (all P<0.0001), with higher creatinine [(10.5±4.3) mg/L vs (9.9±2.9) mg/L, P<0.0001] and the number of white blood cells [(7.49±2.86)× 109/L vs (7.19 ± 2.62) × 109/L, P=0.008) compared with those without metabolic syndrome. The patients with metabolic syndrome showed severer coronary angiographic alterations (left main artery and/or ≥2-vessel)(73.6% vs 69.6%, P=0.031). There were no significant differences of major adverse cardiac and cerebral events(MACCE) or mortality in hospital between the two groups. During followup, the ratio of MACCE in CAD with metabolic syndrome patients increased significantly (11.8% vs 10.0%, P=0.044). Fasting blood glucose (≥ 1000mg/L) and triglyceride (TG, ≥ 1500 mg/L) were responsible for most of the increased risk associated with the metabolic syndrome (adjusted OR 1.465, 95% CI 1.037-1.874, P=0.032; OR 1.378, 95% CI 1.014-1.768,P=0.044).Conclusions The prevalence of metabolic

  11. Adverse events associated with acupuncture: three multicentre randomized controlled trials of 1968 cases in China

    Directory of Open Access Journals (Sweden)

    Zheng Hui

    2011-03-01

    Full Text Available Abstract Background In order to evaluate the safety of acupuncture in China objectively, we investigated the adverse events associated with acupuncture based on three multicentre randomized controlled trials (RCTs to assess the safety of acupuncture, identifying the common types of acupuncture adverse events, and analysing the related risk factors for their occurrence. Methods This observational study included patients who received acupuncture from three multicentre RCTs respectively for migraine, functional dyspepsia and Bell's palsy. The 1968 patients and their acupuncturists documented adverse events associated with acupuncture after treatment. We collected data about adverse events due to acupuncture treatment from their case report forms. We analysed the incidence and details of the adverse effects, and studied the risk factors for acupuncture adverse events with non-conditional logistic regression analysis. Results Among the 1968 patients, 74 patients (3.76% suffered at least one adverse event throughout the treatment period. We did not observe the occurrence of serious adverse events. 73 patients with adverse events recovered within 2 weeks through effective treatment such as physiotherapy or self-treatment. A total of 3 patients withdrew because of adverse events. There were 9 types of adverse events related to acupuncture, including subcutaneous haematoma, bleeding, skin bruising and needle site pain. Subcutaneous haematoma and haemorrhage in the needling points were the most common adverse events. Age and gender were related to the occurrence of acupuncture adverse events. The older the patients were, the higher the risk of adverse events was. In addition, male patients had slightly higher risk of an adverse event than female patients. Conclusions Acupuncture is a safe therapy with low risk of adverse events in clinical practice. The risk factors for adverse events (AEs were related to the patients' gender and age and the local

  12. Current prognosis and quality of life following surgical treatment for head and neck squamous cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    Cristina Hernández-Vila

    2016-01-01

    Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in the world with a close relation with some risk factor like, tobacco, alcohol consumption and more recently, with human papilloma virus infection. A review of the literature about actual prognosis and quality of life in HNSCC has been done analysing the results of surgical treatment and their impact on the quality of life of patients. Despite the elevated incidence of HNSCC, the survival rate has increased considerably over the last years thanks to the development of new surgical techniques, such as, microvascular reconstruction or transoral robotic surgery and the most accurate adjuvant radiochemotherapy. Even in bad prognosis cases, there are many options to take into account not only with curative expectation, even, keeping in mind the preservation of the quality of life of patients. Due to the improvement of the prognosis, the interest of surgeons has been focused on preserve the aesthetics, functional and psychosocial aspect of patients without a worsening of the main objective which is the curative result. Although prognosis of HNSCC has improved, further studies are necessary to understand the behaviour in every case and determine how the impact on the quality of life can be a useful tool to individualize the therapies.

  13. Clinicopathological Characteristics and Prognosis of Colorectal Cancer in Chinese Adolescent Patients

    Institute of Scientific and Technical Information of China (English)

    Feng Du; Su-Sheng Shi; Yong-Kun Sun; Jin-Wan Wang; Yihebali Chi

    2015-01-01

    Background: Colorectal adenocarcinoma rarely occurred in adolescent.Clinical feature and prognosis of this population are not clear until now.In addition, DNA mismatch repair (MMR) status may relate to the early disease occurrence.The present study aimed to perform a retrospective analysis of adolescent patients with colorectal cancer, including clinicopathological characteristics and prognosis.Methods: The medical records of 11,503 patients diagnosed as colorectal cancer in Cancer Hospital, Chinese Academy of Medical Sciences from January 1999 to December 2009 were retrospectively reviewed.Finally, 19 patients who were between 10 and 20 years old were selected as the study group.We summarized the clinicopathological characteristics, analyzed the association with prognosis and assessed the expression of MMR protein by immunohistochemical method.Results: The most common primary site was the right colon in 7 patients.Ten patients had Stage Ⅲ colorectal cancer, 5 patients had Stage Ⅳ disease.Signet ring cell carcinoma was the most fiequent pathological type (7/19).Deficient MMR was identified in 2 patients.The 5-year survival rate and median survival time were 23.2% and 26 months.Distant metastasis was identified as an independent prognostic factor (P =0.02).Conclusions: Colorectal cancer in Chinese adolescents was very rare.The chinese adolecents with colorectal cancer were frequently diagnosed in the right colon, as Stage Ⅲ/Ⅳ disease with signet ring cell carcinoma.The prognosis was relatively poor.

  14. Childhood adversities and risk for problematic alcohol use.

    Science.gov (United States)

    Dragan, Małgorzata; Hardt, Jochen

    2016-08-01

    The findings from studies exploring the relationship between childhood adversities (CAs) and adolescent and adult drinking problems are inconclusive - some researchers have found strong effects, others virtually none. In this study, we sought to examine the associations between 23 types of retrospectively reported CAs and adult problematic alcohol use in two samples, one drawn from Germany, the other from Poland. A total sample of 1008 participants was recruited via the internet: 500 in Germany and 508 in Poland. They completed a set of questionnaires including questions regarding various types of CA, and also the CAGE tool for the identification of problem drinking. CAs were grouped into four categories: Negative Personal Experience, Family Adversities, Parental Disorders, Parent-Child Relationships; this last category included role reversal. Separate logistic regression analyses were performed, with age, gender and country as potential confounders. The probability of having an alcohol problem was higher in men, and higher in Poland than in Germany. Of the risk factors tested, three displayed a significant association with problematic alcohol use. The risk factors concerned were Regular Arguments Between the Parents, plus two types of adversities from the Parent-Child Relationships cluster: Maternal Control and Maternal Role Reversal. The results serve to underline the importance of examining links between childhood risk factors and problematic alcohol use, and also suggest that certain less visible symptoms of a disordered parent-child (particularly mother-child) relationship, such as parentification, may constitute important risk factors for the development of drinking problems in later life. PMID:27082746

  15. 双(多)胎儿发生脑瘫的相关因素调查分析及早期干预对预后的影响%Related factor analysis of cerebral palsy in twin or multiple pregnancies and the effect of early intervention on prognosis

    Institute of Scientific and Technical Information of China (English)

    刘振玲; 何爽; 陈芳; 覃京; 黄秀丽

    2013-01-01

    Objective To explore the related factors of cerebral palsy in twin or multiple pregnancies ,and the effect of early intervention on prognosis .Methods One hundred and fifty nine cases of twin or multiple pregnancy from 86 families in the perinatal period were investigated by retrospective investigation and analysis method , and as-sessed them by Gesell scale at the same time, the results were comprehensively analyzed .Results There were 106 cases of cerebral palsy in 159 cases twin or multiple pregnancies , the cerebral palsy rate was 66.7%(106/159). There were 94 cases of cerebral palsy among 143 babies of twin or multiple pregnancies , the cerebral palsy rate was 65.7%(94/143).After the rehabilitation treatment, the cerebral palsy rate was 14.5%(23/159), There were many high risk factors of cerebral palsy , which in turn was premature birth, low birth weight, hyperbilirubinemia, hypoxic ischemic encephalopathy, asphyxia, neonatal pneumonia, hypoglycemia, gestational diabetes, in-vitro fertilization and cesarean section.Conclusion Twin or multiple pregnancies are prong to premature birth; there were positive correlation between infantile cerebral palsy and their high risk factors .But early intervention could significantly re-duce the incidence of cerebral palsy , and the smaller age of rehabilitation therapy , the better results, and the optimal treatment time window was before 6 months age.%目的探讨双(多)胎儿发生脑瘫的相关因素及早期干预对预后的影响。方法采用回顾性调查分析的方法,对86个家庭的159例双胎或多胎患儿进行围产期调查,同时给予Gesell测评,并对结果进行综合分析。结果159例多(双)胎儿中诊断脑瘫106例,脑瘫发生率为66.7%,其中婴儿脑瘫94例(65.7%),康复治疗后治愈83例,最终脑瘫发生率为14.5%(23/159)。脑瘫的高危因素依次为早产、低出生体重、高胆红素血症、缺氧缺血性脑病、窒息、新生

  16. Reproductive prognosis in daughters of women with and without endometriosis

    DEFF Research Database (Denmark)

    Dalsgaard, T; Hansen, Maj Vadskjær Hjordt; Hartwell, D; Lidegaard, O

    2013-01-01

    Do daughters of women with endometriosis exhibit an increased risk of endometriosis and impaired long-term reproductive prognosis when compared with daughters of women without endometriosis?......Do daughters of women with endometriosis exhibit an increased risk of endometriosis and impaired long-term reproductive prognosis when compared with daughters of women without endometriosis?...

  17. The NAS Perchlorate Review: Adverse Effects?

    Energy Technology Data Exchange (ETDEWEB)

    Johnston, Richard B.; Corley, Richard; Cowan, Linda; Utiger, Robert D.

    2005-11-01

    ), a dose of 9.2 mg/kg per day for 4 weeks had no effect on thyroid function. In occupational studies, doses as high as 0.5 mg/kg per day were not associated with adverse effects on thyroid function in workers. In epidemiologic studies, there were no abnormalities in growth or thyroid function in children exposed life-long to 100 to 120 mg of perchlorate per liter of drinking water, or in pregnant women and newborn infants similarly exposed. Given the choice of a non-adverse effect (inhibition of iodide uptake by the thyroid) as the point of departure and the multiple studies in which doses of perchlorate much larger than 0.007 mg/kg per day had no effect on any aspect of thyroid function, the committee did not apply a database uncertainty factor. Finally, Ginsberg and Rice argue that inhibition of thyroid iodide uptake is adverse. That conclusion assumes that any acute inhibition would be sustained, so that thyroid hormone production would fall. That is not the case. There is remarkable compensation for even substantial reductions in thyroid iodide uptake – and thyroid hormone production. As noted above, subjects given 0.04 mg/kg per day for 6 months and 9.2 mg/kg per day for 4 weeks-doses that certainly would inhibit thyroid iodide uptake for a few weeks-had no fall in serum thyroid hormone or rise in serum thyrotropin concentrations (the hallmark of even minor systemic thyroid deficiency). Short-term inhibition of thyroid iodide uptake is not an adverse effect; it has no adverse consequences, because there is rapid compensation mediated by several independent processes. One is upregulation of the thyroid sodium-iodide transport system, as a result of intrathyroidal iodide deficiency. The second, should there be even a very small fall in thyroid hormone production, is an increase in thyrotropin secretion, resulting in overall stimulation of the thyroid gland.

  18. Learning in the Face of Adversity

    OpenAIRE

    Abdul-Hamid, Husein; Patrinos, Harry Anthony; Reyes, Joel; Kelcey, Jo; Diaz Varela, Andrea

    2014-01-01

    The goal of this study is to provide a better understanding of how a school system can operate efficiently under adversity. The results of this work will be useful in identifying relevant policies in the Middle East and North Africa region. Palestine refugees are achieving higher-than-average learning outcomes in spite of the adverse circumstances they live under. Their education system th...

  19. Immunophenotypes and Immune Markers Associated with Acute Promyelocytic Leukemia Prognosis

    Directory of Open Access Journals (Sweden)

    Fang Xu

    2014-01-01

    Full Text Available CD2+, CD34+, and CD56+ immunophenotypes are associated with poor prognoses of acute promyelocytic leukemia (APL. The present study aimed to explore the role of APL immunophenotypes and immune markers as prognostic predictors on clinical outcomes. A total of 132 patients with de novo APL were retrospectively analyzed. Immunophenotypes were determined by flow cytometry. Clinical features, complete remission (CR, relapse, and five-year overall survival (OS rate were assessed and subjected to multivariate analyses. The CD13+CD33+HLA-DR-CD34− immunophenotype was commonly observed in patients with APL. Positive rates for other APL immune markers including cMPO, CD117, CD64, and CD9 were 68.7%, 26%, 78.4%, and 96.6%, respectively. When compared with patients with CD2− APL, patients with CD2+ APL had a significantly higher incidence of early death (50% versus 15.7%; P=0.016, lower CR rate (50% versus 91.1%; P=0.042, and lower five-year OS rate (41.7% versus 74.2%; P=0.018. White blood cell (WBC count before treatment was found to be the only independent risk factor of early death, CR failure, and five-year mortality rate. Flow cytometric immunophenotype analysis can facilitate prompt APL diagnosis. Multivariate analysis has demonstrated that WBC count before treatment is the only known independent risk factor that predicts prognosis for APL in this study population.

  20. Hodgkin lymphoma post-transplant lymphoproliferative disorder: A comparative analysis of clinical characteristics, prognosis, and survival.

    Science.gov (United States)

    Rosenberg, Aaron S; Klein, Andreas K; Ruthazer, Robin; Evens, Andrew M

    2016-06-01

    Hodgkin lymphoma post-transplant lymphoproliferative disorder (HL-PTLD) is an uncommon PTLD with unclear prognosis and differences between HL-PTLD and immunocompetent HL are not well defined. Patient characteristics were compared among 192 patients with HL-PTLD from the Scientific Registry of Transplant Recipients and 13,847 HL patients in SEER (HL-SEER). Overall survival (OS) and disease-specific survival (DSS) were compared after exact matching. Additionally, multivariable analyses were used to identify prognostic markers of survival and associations between treatment and survival. Median time from transplant to HL-PTLD diagnosis was 88 months. When compared with HL-SEER, patients with HL-PTLD were older (median age, 52 vs. 36 years, P = 0.001), more likely male (73% vs. 54%, P < 0.001), Caucasian (81% vs. 70%, P = 0.02), and had extranodal disease (42% vs. 3%, P < 0.001). Five-year OS for patients with HL-PTLD was 57% versus 80% for HL-SEER (P < 0.001); DSS was also inferior (P < 0.001). For patients with HL-PTLD, the use of any chemotherapy was associated with decreased hazard of death (HR = 0.36, P < 0.001). Furthermore, patients who received no chemotherapy or nontraditional HL regimens had increased hazard of death (aHR = 2.94, P = 0.001 and 2.01, P = 0.04) versus HL-specific chemotherapy regimens. In multivariable analysis, advanced age and elevated creatinine were associated with inferior OS (aHR = 1.26/decade P < 0.001 and 1.64/0.1 mg/dL increase P = 0.02). A prognostic score based on the number of these adverse factors (0, 1, 2) was associated with 10-year OS rates of 79%, 53%, and 11%, respectively (P < 0.001). Altogether, HL-PTLD patients have inferior survival when compared with HL-SEER. Furthermore, treatment with HL-specific chemotherapy was associated with improved OS, whereas age and creatinine identified patients with markedly divergent survival. Am. J. Hematol. 91:560-565, 2016. © 2016