[OMICS AND BIG DATA, MAJOR ADVANCES TOWARDS PERSONALIZED MEDICINE OF THE FUTURE?].

Science.gov (United States)

Scheen, A J

2015-01-01

The increasing interest for personalized medicine evolves together with two major technological advances. First, the new-generation, rapid and less expensive, DNA sequencing method, combined with remarkable progresses in molecular biology leading to the post-genomic era (transcriptomics, proteomics, metabolomics). Second, the refinement of computing tools (IT), which allows the immediate analysis of a huge amount of data (especially, those resulting from the omics approaches) and, thus, creates a new universe for medical research, that of analyzed by computerized modelling. This article for scientific communication and popularization briefly describes the main advances in these two fields of interest. These technological progresses are combined with those occurring in communication, which makes possible the development of artificial intelligence. These major advances will most probably represent the grounds of the future personalized medicine.

Cognitive load privileges memory-based over data-driven processing, not group-level over person-level processing.

Science.gov (United States)

Skorich, Daniel P; Mavor, Kenneth I

2013-09-01

In the current paper, we argue that categorization and individuation, as traditionally discussed and as experimentally operationalized, are defined in terms of two confounded underlying dimensions: a person/group dimension and a memory-based/data-driven dimension. In a series of three experiments, we unconfound these dimensions and impose a cognitive load. Across the three experiments, two with laboratory-created targets and one with participants' friends as the target, we demonstrate that cognitive load privileges memory-based over data-driven processing, not group- over person-level processing. We discuss the results in terms of their implications for conceptualizations of the categorization/individuation distinction, for the equivalence of person and group processes, for the ultimate 'purpose' and meaningfulness of group-based perception and, fundamentally, for the process of categorization, broadly defined. © 2012 The British Psychological Society.

FFTF and Advanced Reactors Transition Program Resource Loaded Schedule

Energy Technology Data Exchange (ETDEWEB)

GANTT, D.A.

2000-10-31

This Resource Load Schedule (RLS) addresses two missions. The Advanced Reactors Transition (ART) mission, funded by DOE-EM, is to transition assigned, surplus facilities to a safe and compliant, low-cost, stable, deactivated condition (requiring minimal surveillance and maintenance) pending eventual reuse or D&D. Facilities to be transitioned include the 309 Building Plutonium Recycle Test Reactor (PRTR) and Nuclear Energy Legacy facilities. This mission is funded through the Environmental Management (EM) Project Baseline Summary (PBS) RL-TP11, ''Advanced Reactors Transition.'' The second mission, the Fast Flux Test Facility (FFTF) Project, is funded through budget requests submitted to the Office of Nuclear Energy, Science and Technology (DOE-NE). The FFTF Project mission is maintaining the FFTF, the Fuels and Materials Examination Facility (FMEF), and affiliated 400 Area buildings in a safe and compliant standby condition. This mission is to preserve the condition of the plant hardware, software, and personnel in a manner not to preclude a plant restart. This revision of the Resource Loaded Schedule (RLS) is based upon the technical scope in the latest revision of the following project and management plans: Fast Flux Test Facility Standby Plan (Reference 1); Hanford Site Sodium Management Plan (Reference 2); and 309 Building Transition Plan (Reference 4). The technical scope, cost, and schedule baseline is also in agreement with the concurrent revision to the ART Fiscal Year (FY) 2001 Multi-Year Work Plan (MYWP), which is available in an electronic version (only) on the Hanford Local Area Network, within the ''Hanford Data Integrator (HANDI)'' application.

Multicycle Optimization of Advanced Gas-Cooled Reactor Loading Patterns Using Genetic Algorithms

International Nuclear Information System (INIS)

Ziver, A. Kemal; Carter, Jonathan N.; Pain, Christopher C.; Oliveira, Cassiano R.E. de; Goddard, Antony J. H.; Overton, Richard S.

2003-01-01

A genetic algorithm (GA)-based optimizer (GAOPT) has been developed for in-core fuel management of advanced gas-cooled reactors (AGRs) at HINKLEY B and HARTLEPOOL, which employ on-load and off-load refueling, respectively. The optimizer has been linked to the reactor analysis code PANTHER for the automated evaluation of loading patterns in a two-dimensional geometry, which is collapsed from the three-dimensional reactor model. GAOPT uses a directed stochastic (Monte Carlo) algorithm to generate initial population members, within predetermined constraints, for use in GAs, which apply the standard genetic operators: selection by tournament, crossover, and mutation. The GAOPT is able to generate and optimize loading patterns for successive reactor cycles (multicycle) within acceptable CPU times even on single-processor systems. The algorithm allows radial shuffling of fuel assemblies in a multicycle refueling optimization, which is constructed to aid long-term core management planning decisions. This paper presents the application of the GA-based optimization to two AGR stations, which apply different in-core management operational rules. Results obtained from the testing of GAOPT are discussed

Advanced and flexible genetic algorithms for BWR fuel loading pattern optimization

International Nuclear Information System (INIS)

Martin-del-Campo, Cecilia; Palomera-Perez, Miguel-Angel; Francois, Juan-Luis

2009-01-01

This work proposes advances in the implementation of a flexible genetic algorithm (GA) for fuel loading pattern optimization for Boiling Water Reactors (BWRs). In order to avoid specific implementations of genetic operators and to obtain a more flexible treatment, a binary representation of the solution was implemented; this representation had to take into account that a little change in the genotype must correspond to a little change in the phenotype. An identifier number is assigned to each assembly by means of a Gray Code of 7 bits and the solution (the loading pattern) is represented by a binary chain of 777 bits of length. Another important contribution is the use of a Fitness Function which includes a Heuristic Function and an Objective Function. The Heuristic Function which is defined to give flexibility on the application of a set of positioning rules based on knowledge, and the Objective Function that contains all the parameters which qualify the neutronic and thermal hydraulic performances of each loading pattern. Experimental results illustrating the effectiveness and flexibility of this optimization algorithm are presented and discussed.

Effect of an End-of-Life Planning Intervention on the completion of advance directives in homeless persons: a randomized trial.

Science.gov (United States)

Song, John; Ratner, Edward R; Wall, Melanie M; Bartels, Dianne M; Ulvestad, Nancy; Petroskas, Dawn; West, Melissa; Weber-Main, Anne Marie; Grengs, Leah; Gelberg, Lillian

2010-07-20

Few interventions have focused on improving end-of-life care for underserved populations, such as homeless persons. To determine whether homeless persons will complete a counseling session on advance care planning and fill out a legal advance directive designed to assess care preferences and preserve the dignity of marginalized persons. Prospective, single-blind, randomized trial comparing self-guided completion of an advance directive with professionally assisted advance care planning. (ClinicalTrials.gov registration number: NCT00546884) 8 sites serving homeless persons in Minneapolis, Minnesota. 262 homeless persons recruited between November 2007 and August 2008. Minimal, self-guided intervention consisting of advance directive forms and written educational information versus a one-on-one advance planning intervention consisting of counseling and completing an advance directive with a social worker. Rate of advance directive completion, assessed by inspection of completed documents. The overall completion rate for advance directives was 26.7% (95% CI, 21.5% to 32.5%), with a higher rate in the counselor-guided group (37.9%) than in the self-guided group (12.8%) (CI of adjusted difference, 15.3 to 34.3 percentage points). This difference persisted across all sites and most subgroups. The advance directive's 4 clinical scenarios found a preference for surrogate decision making in 29% to 34% of written responses. Sampling was limited to a more stable subset of the homeless population in Minneapolis and may have been subject to selection bias. Modest compensation to complete the preintervention survey could have influenced participants to complete advance directives. Both a simple and complex intervention successfully engaged a diverse sample of homeless persons in advance care planning. One-on-one assistance significantly increased the completion rate. Homeless persons can respond to an intervention to plan for end-of-life care and can express specific preferences

Spatial electric load forecasting

CERN Document Server

Willis, H Lee

2002-01-01

Spatial Electric Load Forecasting Consumer Demand for Power and ReliabilityCoincidence and Load BehaviorLoad Curve and End-Use ModelingWeather and Electric LoadWeather Design Criteria and Forecast NormalizationSpatial Load Growth BehaviorSpatial Forecast Accuracy and Error MeasuresTrending MethodsSimulation Method: Basic ConceptsA Detailed Look at the Simulation MethodBasics of Computerized SimulationAnalytical Building Blocks for Spatial SimulationAdvanced Elements of Computerized SimulationHybrid Trending-Simulation MethodsAdvanced

Health-illness transition among persons using advanced medical technology at home.

Science.gov (United States)

Fex, Angelika; Flensner, Gullvi; Ek, Anna-Christina; Söderhamn, Olle

2011-06-01

This study aimed to elucidate meanings of health-illness transition experiences among adult persons using advanced medical technology at home. As an increasing number of persons perform self-care while using different sorts of advanced medical technology at home, knowledge about health-illness transition experiences in this situation may be useful to caregivers in supporting these patients. A qualitative design was used. Five women and five men, all of whom performed self-care at home, either using long-term oxygen therapy from a ventilator or oxygen cylinder, or performing peritoneal or haemodialysis, were interviewed. Ethics committee approval was obtained. Informed consent was received from all participants, and ethical issues concerning their rights in research were raised. The interviews were analysed using a phenomenological hermeneutical methodology, including both an inductive and a deductive structural analysis. This method offers possibilities to obtain an increased understanding by uncovering a deeper meaning of lived experiences through interviews transcribed as texts. The health-illness transition for adult persons in this context was found to mean a learning process of accepting, managing, adjusting and improving daily life with technology, facilitated by realizing the gain from technology at home. Further, the meaning of the health-illness transition experience was interpreted as contentment with being part of the active and conscious process towards transcending into a new state of living, in which the individual and the technology were in tune. The healthy transition experience was characterized by human growth and becoming. This study elucidates one meaning of health-illness transition experiences in relation to the use of advanced medical technology on a more generic level, independent of the specific type of technology used. A positive attitude towards technology at home facilitates the transition. © 2010 The Authors. Scandinavian Journal of

WPA ISSPD educational program: Module II. Advances in research and understanding of personality disorders

DEFF Research Database (Denmark)

Ronningstam, Elsa; Simonsen, Erik; Millon, Theodore

2009-01-01

of their heritability and aetiological origin, variability over time and between cultures, and change and remission. A curriculum suggesting different educational approaches to the programme, now available on the Internet, aims at promoting integrative learning and discussion among clinicians and educators in study......Recent advances in research, clinical observations and treatment have contributed to several major changes in the conceptualization of personality disorders. Featured in an educational programme on personality disorders prepared by the World Psychiatric Association (WPA) Section on Personality...

Reduction of repository heat load using advanced fuel cycles

International Nuclear Information System (INIS)

Preston, Jeff; Miller, L.F.

2008-01-01

With the geologic repository at Yucca Mountain already nearing capacity full before opening, advanced fuel cycles that introduce reprocessing, fast reactors, and temporary storage sites have the potential to allow the repository to support the current reactor fleet and future expansion. An uncertainty analysis methodology that combines Monte Carlo distribution sampling, reactor physics data simulation, and neural network interpolation methods enable investigation into the factor reduction of heat capacity by using the hybrid fuel cycle. Using a Super PRISM fast reactor with a conversion ratio of 0.75, burn ups reach up to 200 MWd/t that decrease the plutonium inventory by about 5 metric tons every 12 years. Using the long burn up allows the footprint of 1 single core loading of FR fuel to have an integral decay heat of about 2.5x10 5 MW*yr over a 1500 year period that replaces the footprint of about 6 full core loadings of LWR fuel for the number of years required to fuel the FR, which have an integral decay heat of about.3 MW*yr for the same time integral. This results in an increase of a factor of 4 in repository support capacity from implementing a single fast reactor in an equilibrium cycle. (authors)

Cognitive load measurement as a means to advance cognitive load theory

NARCIS (Netherlands)

Paas, F.; Tuovinen, J.E.; Tabbers, H.; van Gerven, P.W.M.

2003-01-01

This paper discusses cognitive load measurement techniques with regard to their contribution to cognitive load theory (CLT). CLT is concerned with the design of instructional methods that efficiently use people's limited cognitive processing capacity to apply acquired knowledge and skills to new

On the flexibility of grammatical advance planning during sentence production: Effects of cognitive load on multiple lexical access.

Science.gov (United States)

Wagner, Valentin; Jescheniak, Jörg D; Schriefers, Herbert

2010-03-01

Three picture-word interference experiments addressed the question of whether the scope of grammatical advance planning in sentence production corresponds to some fixed unit or rather is flexible. Subjects produced sentences of different formats under varying amounts of cognitive load. When speakers described 2-object displays with simple sentences of the form "the frog is next to the mug," the 2 nouns were found to be lexically-semantically activated to similar degrees at speech onset, as indexed by similarly sized interference effects from semantic distractors related to either the first or the second noun. When speakers used more complex sentences (including prenominal color adjectives; e.g., "the blue frog is next to the blue mug") much larger interference effects were observed for the first than the second noun, suggesting that the second noun was lexically-semantically activated before speech onset on only a subset of trials. With increased cognitive load, introduced by an additional conceptual decision task and variable utterance formats, the interference effect for the first noun was increased and the interference effect for second noun disappeared, suggesting that the scope of advance planning had been narrowed. By contrast, if cognitive load was induced by a secondary working memory task to be performed during speech planning, the interference effect for both nouns was increased, suggesting that the scope of advance planning had not been affected. In all, the data suggest that the scope of advance planning during grammatical encoding in sentence production is flexible, rather than structurally fixed.

Identifying relationships between the professional culture of pharmacy, pharmacists' personality traits, and the provision of advanced pharmacy services.

Science.gov (United States)

Rosenthal, Meagen; Tsao, Nicole W; Tsuyuki, Ross T; Marra, Carlo A

2016-01-01

Legislative changes are affording pharmacists the opportunity to provide more advanced pharmacy services. However, many pharmacists have not yet been able to provide these services sustainably. Research from implementation science suggests that before sustained change in pharmacy can be achieved an improved understanding of pharmacy context, through the professional culture of pharmacy and pharmacists' personality traits, is required. The primary objective of this study was to investigate possible relationships between cultural factors, and personality traits, and the uptake of advanced practice opportunities by pharmacists in British Columbia, Canada. The study design was a cross-sectional survey of registered, and practicing, pharmacists from one Canadian province. The survey gauged respondents' characteristics, practice setting, and the provision of advanced pharmacy services, and contained the Organizational Culture Profile (OCP), a measure of professional culture, as well as the Big Five Inventory (BFI), a measure of personality traits. A total of 945 completed survey instruments were returned. The majority of respondents were female (61%), the average age of respondents was 42 years (SD: 12), and the average number of years in practice was 19 (SD: 12). A significant positive relationship was identified for respondents perceiving greater value in the OCP factors competitiveness and innovation and providing a higher number of all advanced services. A positive relationship was observed for respondents scoring higher on the BFI traits extraversion and the immunizations provided, and agreeableness and openness and medication reviews completed. This is the first work to identify statistically significant relationships between the OCP and BFI, and the provision of advanced pharmacy services. As such, this work serves as a starting place from which to develop more detailed insight into how the professional culture of pharmacy and pharmacists personality traits may

NWTC Researchers Field-Test Advanced Control Turbine Systems to Increase Performance, Decrease Structural Loading of Wind Turbines and Plants

Energy Technology Data Exchange (ETDEWEB)

2015-08-01

Researchers at the National Renewable Energy Laboratory's (NREL's) National Wind Technology Center (NWTC) are studying component controls, including new advanced actuators and sensors, for both conventional turbines as well as wind plants. This research will help develop innovative control strategies that reduce aerodynamic structural loads and improve performance. Structural loads can cause damage that increase maintenance costs and shorten the life of a turbine or wind plant.

Understanding of advance care planning by family members of persons undergoing hemodialysis.

Science.gov (United States)

Calvin, Amy O; Engebretson, Joan C; Sardual, S Alexander

2014-11-01

The purpose of this qualitative descriptive study was to explore hemodialysis patients' family members' understanding of end-of-life decision-making processes. The project aimed to address (a) family members' constructions of advance care planning (ACP), including their roles and responsibilities, and (b) family members' perceptions of health care providers' roles and responsibilities in ACP. Eighteen family members of persons undergoing hemodialysis were recruited primarily from outpatient dialysis facilities and interviewed individually. Confirmed transcript data were analyzed, coded, and compared, and categories were established. Interpretations were validated throughout the interviews and peer debriefing sessions were used at a later stage in the analysis. The overarching construct identified was one of Protection. Family members protect patients by (a) Sharing Burdens, (b) Normalizing Life, and (c) Personalizing Care. Recommendations for future research include the need to explore ACP of persons undergoing hemodialysis who do not have a family support system. © The Author(s) 2013.

Chronically homeless persons' participation in an advance directive intervention: A cohort study.

Science.gov (United States)

Leung, Alexander K; Nayyar, Dhruv; Sachdeva, Manisha; Song, John; Hwang, Stephen W

2015-09-01

Chronically homeless individuals have high rates of hospitalization and death, and they may benefit from the completion of advance directives. To determine the rate of advance directive completion using a counselor-guided intervention, identify characteristics associated with advance directive completion, and describe end-of-life care preferences in a group of chronically homeless individuals. Participants completed a survey and were offered an opportunity to complete an advance directive with a trained counselor. A total of 205 residents of a shelter in Canada for homeless men (89.1% of those approached) participated from April to June 2013. Duration of homelessness was ⩾12 months in 72.8% of participants, and 103 participants (50.2%) chose to complete an advance directive. Socio-demographic characteristics, health status, and health care use were not associated with completion of an advance directive. Participants were more likely to complete an advance directive if they reported thinking about death on a daily basis, believed that thinking about their friends and family was important, or reported knowing their wishes for end-of-life care but not having told anyone about these wishes. Among individuals who completed an advance directive, 61.2% named a substitute decision maker, and 94.1% expressed a preference to receive cardiopulmonary resuscitation in the event of a cardiorespiratory arrest if there was a chance of returning to their current state of health. A counselor-guided intervention can achieve a high rate of advance directive completion among chronically homeless persons. Most participants expressed a preference to receive cardiopulmonary resuscitation in the event of a cardiorespiratory arrest. © The Author(s) 2015.

On the Flexibility of Grammatical Advance Planning During Sentence Production: Effects of Cognitive Load on Multiple Lexical Access

NARCIS (Netherlands)

Wagner, V.; Jescheniak, J.D.; Schriefers, H.J.

2010-01-01

Three picture-word interference experiments addressed the question of whether the scope of grammatical advance planning in sentence production corresponds to some fixed unit or rather is flexible. Subjects produced sentences of different formats under varying amounts of cognitive load. When speakers

Operational Strategy of CBPs for load balancing of Operators in Advanced Main Control Room

International Nuclear Information System (INIS)

Kim, Seunghwan; Kim, Yochan; Jung, Wondea

2014-01-01

With the using of a computer-based control room in an APR1400 (Advanced Pressurized Reactor-1400), the operators' behaviors in the main control room had changed. However, though the working environment of operators has been changed a great deal, digitalized interfaces can also change the cognitive tasks or activities of operators. First, a shift supervisor (SS) can confirm/check the conduction of the procedures and the execution of actions of board operators (BOs) while confirming directly the operation variables without relying on the BOs. Second, all operators added to their work the use of a new CBP and Soft Controls, increasing their procedural workload. New operational control strategies of CBPs are necessary for load balancing of operator's task load in APR1400. In this paper, we compared the workloads of operators in an APR1400 who work with two different usages of the CBP. They are SS oriented usage and SS-BO collaborative usage. In this research, we evaluated the workloads of operators in an advanced main control room by the COCOA method. Two types of CBP usages were defined and the effects of these usages on the workloads were investigated. The obtained results showed that the workloads between operators in a control room can be balanced according to the CBP usages by assigning control authority to the operators

Operational Strategy of CBPs for load balancing of Operators in Advanced Main Control Room

Energy Technology Data Exchange (ETDEWEB)

Kim, Seunghwan; Kim, Yochan; Jung, Wondea [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2014-05-15

With the using of a computer-based control room in an APR1400 (Advanced Pressurized Reactor-1400), the operators' behaviors in the main control room had changed. However, though the working environment of operators has been changed a great deal, digitalized interfaces can also change the cognitive tasks or activities of operators. First, a shift supervisor (SS) can confirm/check the conduction of the procedures and the execution of actions of board operators (BOs) while confirming directly the operation variables without relying on the BOs. Second, all operators added to their work the use of a new CBP and Soft Controls, increasing their procedural workload. New operational control strategies of CBPs are necessary for load balancing of operator's task load in APR1400. In this paper, we compared the workloads of operators in an APR1400 who work with two different usages of the CBP. They are SS oriented usage and SS-BO collaborative usage. In this research, we evaluated the workloads of operators in an advanced main control room by the COCOA method. Two types of CBP usages were defined and the effects of these usages on the workloads were investigated. The obtained results showed that the workloads between operators in a control room can be balanced according to the CBP usages by assigning control authority to the operators.

Load Variation Influences on Joint Work During Squat Exercise in Reduced Gravity

Science.gov (United States)

DeWitt, John K.; Fincke, Renita S.; Logan, Rachel L.; Guilliams, Mark E.; Ploutz-Snyder, Lori L.

2011-01-01

Resistance exercises that load the axial skeleton, such as the parallel squat, are incorporated as a critical component of a space exercise program designed to maximize the stimuli for bone remodeling and muscle loading. Astronauts on the International Space Station perform regular resistance exercise using the Advanced Resistive Exercise Device (ARED). Squat exercises on Earth entail moving a portion of the body weight plus the added bar load, whereas in microgravity the body weight is 0, so all load must be applied via the bar. Crewmembers exercising in microgravity currently add approx.70% of their body weight to the bar load as compensation for the absence of the body weight. This level of body weight replacement (BWR) was determined by crewmember feedback and personal experience without any quantitative data. The purpose of this evaluation was to utilize computational simulation to determine the appropriate level of BWR in microgravity necessary to replicate lower extremity joint work during squat exercise in normal gravity based on joint work. We hypothesized that joint work would be positively related to BWR load.

Advances in High Power Calorimetric Matched Loads for Short Pulses and CW Gyrotrons

International Nuclear Information System (INIS)

Bin, W.M.; Bruschi, A.; Cirant, S.; Gandini, F.; Granucci, G.; Mellera, V.; Muzzini, V.; Nardone, A.; Sozzi, C.; Spinicchia, N.

2006-01-01

The development of high power gyrotrons for plasma physics research needs proper matched and calorimetric loads able to absorb and measure the power, which nowadays is foreseen to be as high as 2 MW during CW operations. To this end IFP/CNR has developed a family of matched loads useful in the mm-wave frequency band for applications ranging from a few ms to CW in pulse length. The different loads in the family, made of an integrating sphere with a partially reflecting coating on the inner wall, are characterized by having the same absorbing geometry for the incoming beam and a different heat removal system for the specific application. Some important advances have been recently achieved from the point of view of the uniformity of power distribution on the absorbing wall and of the load construction. With high precision achieved in the coating thickness a better control of the heating power distribution is possible by proper shaping of the local reflectivity, in addition to the shaping of the mirror dispersing the input beam. A more sophisticated model describing the power distribution has been developed, taking into account a variable thickness of the absorbing coating, the proper shape of the spreading mirror, the frequency of the incoming radiation and the shape of the input beam. Lower coating thickness is shown to be preferable, at equal local reflectivity, from the point of view of a lower peak temperature and thermal stress. The paper describes a load with variable coating thickness along the meridian of the sphere, showing a uniform power deposition on the inner walls. The cooling pipe is completely electroformed on the spherical copper shell, ensuring the maintenance of the correct curvature of the inner surface and a fast heat conduction from the absorbing coating to the water through the thin copper body. For CW use all heated parts of the load must be cooled and this is achieved by 16 electroformed spiral channels. Both short pulse loads (0.1-1 s) and

On the Flexibility of Grammatical Advance Planning during Sentence Production: Effects of Cognitive Load on Multiple Lexical Access

Science.gov (United States)

Wagner, Valentin; Jescheniak, Jorg D.; Schriefers, Herbert

2010-01-01

Three picture-word interference experiments addressed the question of whether the scope of grammatical advance planning in sentence production corresponds to some fixed unit or rather is flexible. Subjects produced sentences of different formats under varying amounts of cognitive load. When speakers described 2-object displays with simple…

Music Therapy as a Way to Enhance Lucidity in Persons with Dementia in Advanced Stages

DEFF Research Database (Denmark)

Ridder, Hanne Mette Ochsner

2005-01-01

Instead of describing dementia as a permanent state of non-lucidity, where the person is not reasonable and reachable, dementia is described as a condition where periods of confusion and dimness might alternate with clear and lucid mental states. In these states, the person with dementia is prese...... in advanced stages. The text is illustrated with case material and is partly based on a PhD thesis (Ridder 2003). The thesis was supervised by David Aldridge and carried out in collaboration with Aalborg University and gerontopsychiatric unit II, nursing home Caritas....

Advancing innovations in social/personality psychology and health: opportunities and challenges.

Science.gov (United States)

Rothman, Alexander J; Klein, William M P; Cameron, Linda D

2013-05-01

Social, personality, and health psychologists have a long tradition of active and productive collaborations that have advanced the development of intervention strategies that promote health and well-being and the specification of the theoretical principles that underlie those strategies. This special issue is designed to continue this tradition of collaboration and to highlight areas of research and investigative strategies that offer opportunities for innovation. This concluding paper examines how investigators construe the interface between theory and practice and, with that lens, considers several themes that have emerged across the papers that comprise this special issue. As evidenced by the papers in this special issue, investigators are well-positioned to leverage advances in understanding of human health and well-being. However, to capitalize on this opportunity, investigators need to commit to cultivating a culture of scientific activity that prioritizes the engagement of theory and practice-the pursuit of both understanding and use. PsycINFO Database Record (c) 2013 APA, all rights reserved.

77 FR 53884 - Automatic Underfrequency Load Shedding and Load Shedding Plans Reliability Standards; Notice of...

Science.gov (United States)

2012-09-04

... Underfrequency Load Shedding and Load Shedding Plans Reliability Standards; Notice of Compliance Filing Take notice that on August 9, 2012, North American Electric Reliability Corporation submitted a compliance... Load Shedding Plans Reliability Standards, 139 FERC ] 61,098, (Order No. 763) (2012). Any person...

Effect of depression on the immune function and tumor load in patients with advanced gastric cancer

Directory of Open Access Journals (Sweden)

Hai-Bo Shi

2017-06-01

Full Text Available Objective: To study the correlation between depression and immune function as well as tumor load in patients with advanced gastric cancer. Methods: 98 patients diagnosed with advanced gastric cancer in our hospital between May 2013 and September 2016 were selected and divided into depression group (n=39 with HAMD scores >50 and non-depression group with HAMD scores≤50 (n=39, serum was collected to detect the levels of cytokines interleukin-2 (IL-2, IL-4, IL-10, IL-17, interferon-γ (IFN-γ and transforming growth factor β1 (TGF- β1 as well as tumor markers carcinoembryonic antigen (CEA, carbohydrate antigen 199 (CA199, CA724, TK-1 and sLAG-3, and gastric cancer tissues were collected to determine the expression of cell cycle-related proteins CyclinD1, CDK4 and E2F. Results: Serum IL-2, IFN-γ and IL-17 levels of depression group were significantly lower than those of non-depression group (P<0.05 while IL-4, IL-10, TGF-β1, CEA, CA199, CA724, TK-1 and sLAG-3 levels were significantly higher than those of non-depression group (P<0.05; CyclinD1, CDK4 and E2F protein expression in tumor tissues of depression group were significantly higher than those of non-depression group (P<0.05. Conclusions: Depression can inhibit the anti-tumor immune response in patients with advanced gastric cancer, and then promote cancer cell proliferation and increase tumor load.

Effect of depression on the immune function and tumor load in patients with advanced gastric cancer

Institute of Scientific and Technical Information of China (English)

Hai-Bo Shi

2017-01-01

Objective:To study the correlation between depression and immune function as well as tumor load in patients with advanced gastric cancer.Methods: 98 patients diagnosed with advanced gastric cancer in our hospital between May 2013 and September 2016 were selected and divided into depression group (n=39) with HAMD scores >50 and non-depression group with HAMD scores≤50 (n=39), serum was collected to detect the levels of cytokines interleukin-2 (IL-2), IL-4, IL-10, IL-17, interferon-γ (IFN-γ) and transforming growth factorβ1 (TGF-β1) as well as tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199), CA724, TK-1 and sLAG-3, and gastric cancer tissues were collected to determine the expression of cell cycle-related proteins CyclinD1, CDK4 and E2F.Results:Serum IL-2, IFN-γand IL-17 levels of depression group were significantly lower than those of non-depression group (P<0.05) while IL-4, IL-10, TGF-β1, CEA, CA199, CA724, TK-1 and sLAG-3 levels were significantly higher than those of non-depression group (P<0.05);CyclinD1, CDK4 and E2F protein expression in tumor tissues of depression group were significantly higher than those of non-depression group (P<0.05).Conclusions:Depression can inhibit the anti-tumor immune response in patients with advanced gastric cancer, and then promote cancer cell proliferation and increase tumor load.

An accurate filter loading correction is essential for assessing personal exposure to black carbon using an Aethalometer.

Science.gov (United States)

Good, Nicholas; Mölter, Anna; Peel, Jennifer L; Volckens, John

2017-07-01

The AE51 micro-Aethalometer (microAeth) is a popular and useful tool for assessing personal exposure to particulate black carbon (BC). However, few users of the AE51 are aware that its measurements are biased low (by up to 70%) due to the accumulation of BC on the filter substrate over time; previous studies of personal black carbon exposure are likely to have suffered from this bias. Although methods to correct for bias in micro-Aethalometer measurements of particulate black carbon have been proposed, these methods have not been verified in the context of personal exposure assessment. Here, five Aethalometer loading correction equations based on published methods were evaluated. Laboratory-generated aerosols of varying black carbon content (ammonium sulfate, Aquadag and NIST diesel particulate matter) were used to assess the performance of these methods. Filters from a personal exposure assessment study were also analyzed to determine how the correction methods performed for real-world samples. Standard correction equations produced correction factors with root mean square errors of 0.10 to 0.13 and mean bias within ±0.10. An optimized correction equation is also presented, along with sampling recommendations for minimizing bias when assessing personal exposure to BC using the AE51 micro-Aethalometer.

Advances in molecular-based personalized non-small-cell lung cancer therapy: targeting epidermal growth factor receptor and mechanisms of resistance

International Nuclear Information System (INIS)

Jotte, Robert M; Spigel, David R

2015-01-01

Molecularly targeted therapies, directed against the features of a given tumor, have allowed for a personalized approach to the treatment of advanced non-small-cell lung cancer (NSCLC). The reversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib had undergone turbulent clinical development until it was discovered that these agents have preferential activity in patients with NSCLC harboring activating EGFR mutations. Since then, a number of phase 3 clinical trials have collectively shown that EGFR-TKI monotherapy is more effective than combination chemotherapy as first-line therapy for EGFR mutation-positive advanced NSCLC. The next generation of EGFR-directed agents for EGFR mutation-positive advanced NSCLC is irreversible TKIs against EGFR and other ErbB family members, including afatinib, which was recently approved, and dacomitinib, which is currently being tested in phase 3 trials. As research efforts continue to explore the various proposed mechanisms of acquired resistance to EGFR-TKI therapy, agents that target signaling pathways downstream of EGFR are being studied in combination with EGFR TKIs in molecularly selected advanced NSCLC. Overall, the results of numerous ongoing phase 3 trials involving the EGFR TKIs will be instrumental in determining whether further gains in personalized therapy for advanced NSCLC are attainable with newer agents and combinations. This article reviews key clinical trial data for personalized NSCLC therapy with agents that target the EGFR and related pathways, specifically based on molecular characteristics of individual tumors, and mechanisms of resistance

Genetic algorithms and artificial neural networks for loading pattern optimisation of advanced gas-cooled reactors

Energy Technology Data Exchange (ETDEWEB)

Ziver, A.K. E-mail: a.k.ziver@imperial.ac.uk; Pain, C.C; Carter, J.N.; Oliveira, C.R.E. de; Goddard, A.J.H.; Overton, R.S

2004-03-01

A non-generational genetic algorithm (GA) has been developed for fuel management optimisation of Advanced Gas-Cooled Reactors, which are operated by British Energy and produce around 20% of the UK's electricity requirements. An evolutionary search is coded using the genetic operators; namely selection by tournament, two-point crossover, mutation and random assessment of population for multi-cycle loading pattern (LP) optimisation. A detailed description of the chromosomes in the genetic algorithm coded is presented. Artificial Neural Networks (ANNs) have been constructed and trained to accelerate the GA-based search during the optimisation process. The whole package, called GAOPT, is linked to the reactor analysis code PANTHER, which performs fresh fuel loading, burn-up and power shaping calculations for each reactor cycle by imposing station-specific safety and operational constraints. GAOPT has been verified by performing a number of tests, which are applied to the Hinkley Point B and Hartlepool reactors. The test results giving loading pattern (LP) scenarios obtained from single and multi-cycle optimisation calculations applied to realistic reactor states of the Hartlepool and Hinkley Point B reactors are discussed. The results have shown that the GA/ANN algorithms developed can help the fuel engineer to optimise loading patterns in an efficient and more profitable way than currently available for multi-cycle refuelling of AGRs. Research leading to parallel GAs applied to LP optimisation are outlined, which can be adapted to present day LWR fuel management problems.

Proceedings of the Workshop on Advanced Network and Technology Concepts for Mobile, Micro, and Personal Communications

Science.gov (United States)

Paul, Lori (Editor)

1991-01-01

The Workshop on Advanced Network and Technology Concepts for Mobile, Micro, and Personal Communications was held at NASA's JPL Laboratory on 30-31 May 1991. It provided a forum for reviewing the development of advanced network and technology concepts for turn-of-the-century telecommunications. The workshop was organized into three main categories: (1) Satellite-Based Networks (L-band, C-band, Ku-band, and Ka-band); (2) Terrestrial-Based Networks (cellular, CT2, PCN, GSM, and other networks); and (3) Hybrid Satellite/Terrestrial Networks. The proceedings contain presentation papers from each of the above categories.

Biomarkers for personalized oncology: recent advances and future challenges.

Science.gov (United States)

Kalia, Madhu

2015-03-01

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells and oncology is a branch of medicine that deals with tumors. The last decade has seen significant advances in the development of biomarkers in oncology that play a critical role in understanding molecular and cellular mechanisms which drive tumor initiation, maintenance and progression. Clinical molecular diagnostics and biomarker discoveries in oncology are advancing rapidly as we begin to understand the complex mechanisms that transform a normal cell into an abnormal one. These discoveries have fueled the development of novel drug targets and new treatment strategies. The standard of care for patients with advanced-stage cancers has shifted away from an empirical treatment strategy based on the clinical-pathological profile to one where a biomarker driven treatment algorithm based on the molecular profile of the tumor is used. Recent advances in multiplex genotyping technologies and high-throughput genomic profiling by next-generation sequencing make possible the rapid and comprehensive analysis of the cancer genome of individual patients even from very little tumor biopsy material. Predictive (diagnostic) biomarkers are helpful in matching targeted therapies with patients and in preventing toxicity of standard (systemic) therapies. Prognostic biomarkers identify somatic germ line mutations, changes in DNA methylation, elevated levels of microRNA (miRNA) and circulating tumor cells (CTC) in blood. Predictive biomarkers using molecular diagnostics are currently in use in clinical practice of personalized oncotherapy for the treatment of five diseases: chronic myeloid leukemia, colon, breast, lung cancer and melanoma and these biomarkers are being used successfully to evaluate benefits that can be achieved through targeted therapy. Examples of these molecularly targeted biomarker therapies are: tyrosine kinase inhibitors in chronic myeloid leukemia and

Personalized treatment for advanced colorectal cancer: KRAS and beyond

International Nuclear Information System (INIS)

Patel, Gargi Surendra; Karapetis, Christos S

2013-01-01

Targeted therapies have improved the survival of patients with advanced colorectal cancer (CRC). However, further improvements in patient outcomes may be gained by the development of predictive biomarkers in order to select individuals who are most likely to benefit from treatment, thus personalizing treatment. Using the epidermal growth-factor receptor (EGFR) pathway, we discuss the existing and potential predictive biomarkers in clinical development for use with EGFR-targeted agents in metastatic CRC. The data and technological issues surrounding such biomarkers as expression of EGFR or its family members or ligands, KRAS-, NRAS-, and BRAF-mutation status, PI3K/PTEN expression, and imaging and clinical biomarkers, such as rash and hypomagnesemia, are summarized. Although the discovery of KRAS mutations has improved patient selection for EGFR-targeted treatments, further biomarkers are required, especially for those patients who exhibit KRAS mutations rather than the wild-type gene

Advances in the Molecular Analysis of Breast Cancer: Pathway Toward Personalized Medicine.

Science.gov (United States)

Rosa, Marilin

2015-04-01

Breast cancer is a heterogeneous disease that encompasses a wide range of clinical behaviors and histological and molecular variants. It is the most common type of cancer affecting women worldwide and is the second leading cause of cancer death. A comprehensive literature search was performed to explore the advances in molecular medicine related to the diagnosis and treatment of breast cancer. During the last few decades, advances in molecular medicine have changed the landscape of cancer treatment as new molecular tests complement and, in many instances, exceed traditional methods for determining patient prognosis and response to treatment options. Personalized medicine is becoming the standard of care around the world. Developments in molecular profiling, genomic analysis, and the discovery of targeted drug therapies have significantly improved patient survival rates and quality of life. This review highlights what pathologists need to know about current molecular tests for classification and prognostic/ predictive assessment of breast carcinoma as well as their role as part of the medical team.

High heat load x-ray optics research and development at the Advanced Photon Source -- An overview

International Nuclear Information System (INIS)

Lee, Wah-Keat; Mills, D.M.

1993-09-01

Insertion devices at third generation synchrotron radiation sources such as the APS are capable of producing x-ray beams with total power in excess of 7 kilowatts or power densities of 150 watts/mm 2 at a typical location of the optical components. Optical elements subjected to these types of heat fluxes will suffer considerably unless carefully designed to withstand these unprecedented power loadings. At the Advanced Photon Source (APS), we have an aggressive R ampersand D program aimed at investigating possible methods to mitigate thermal distortions. The approaches being studied include, improved heat exchangers, use of liquid gallium and liquid nitrogen as coolants, novel crystal geometries, power filtering, and replacement of silicon with diamond for crystal monochromators. This paper will provide an overview of the high heat load x-ray optics program at the APS

Career Advancement, Career Enhancement, and Personal Growth of Pepperdine University's Educational Leadership Academy Graduate Program Alumni

Science.gov (United States)

Nichols, Ruth I.

2012-01-01

The purpose of this phenomenological study was two-fold: (a) to explore and describe the perceived impact of Pepperdine University's Educational Leadership Academy (ELA) on 2003-2006 ELA graduates' career advancement, career enhancement, and personal growth; and (b) to obtain ELA graduates' suggestions for ELA program improvement to better prepare…

Training Effectiveness Evaluation (TEE) of the Advanced Fire Fighting Training System. Focus on the Trained Person.

Science.gov (United States)

Cordell, Curtis C.; And Others

A training effectiveness evaluation of the Navy Advanced Fire Fighting Training System was conducted. This system incorporates simulated fires as well as curriculum materials and instruction. The fires are non-pollutant, computer controlled, and installed in a simulated shipboard environment. Two teams of 15 to 16 persons, with varying amounts of…

Dosimetric advancement of high-dose-rate after-loading 192Ir source

International Nuclear Information System (INIS)

Zhang Shuxu; Li Wenhua; Xu Hairong

2004-01-01

High-dose-rate (HDR) 192 Ir source is a nuclide commonly used in the brachytherapy system. The basic dosimetry data of the near source area is usually measured by pin ion chambers or TLD techniques, but these methods have a lower spatial resolution than Electron spin resonance (ESR) dosimetry which has a spatial resolution of 156 μm, and the Monte Carlo photon transport simulations are taken as the golden standard of those measures. The precision in two-dimensional dose distribution measured by GafChromic film is reported to be 1.0%. In vivo dosimetry using TLD during HDR intracavitary after-loading brachytherapy is a good predictor of late rectal complications. The accuracy of magnetic resonance imaging (MRI) Fricke-gel dosimetry for three-dimensional dose distribution is about 2.5% with a spatial resolution of 1.56 mm. The optical computed tomography polymer gel dosimetry has a unique advance than MRI gel dosimetry

Advances in electric power and energy systems load and price forecasting

CERN Document Server

2017-01-01

A comprehensive review of state-of-the-art approaches to power systems forecasting from the most respected names in the field, internationally. Advances in Electric Power and Energy Systems is the first book devoted exclusively to a subject of increasing urgency to power systems planning and operations. Written for practicing engineers, researchers, and post-grads concerned with power systems planning and forecasting, this book brings together contributions from many of the world’s foremost names in the field who address a range of critical issues, from forecasting power system load to power system pricing to post-storm service restoration times, river flow forecasting, and more. In a time of ever-increasing energy demands, mounting concerns over the environmental impacts of power generation, and the emergence of new, smart-grid technologies, electricity price forecasting has assumed a prominent role within both the academic and industrial ar nas. Short-run forecasting of electricity prices has become nece...

Combined-load stress-strain relationship for advanced fiber composites

Science.gov (United States)

Chamis, C. C.; Sullivan, T. L.

1975-01-01

It was demonstrated experimentally that only one test specimen is required to determine the combined-load stress-strain relationships of a given fiber composite system. These relationships were determined using a thin angle-plied laminate tube and subjecting it to a number of combined-loading conditions. The measured data obtained are compared with theoretical predictions. Some important considerations associated with such a test are identified, and the significance of combined-load stress-strain relationships in certain practical designs are discussed.

Assessment of capabilities in persons with advanced stage of dementia: Validation of The Montessori Assessment System (MAS).

Science.gov (United States)

Erkes, Jérôme; Camp, Cameron J; Raffard, Stéphane; Gély-Nargeot And, Marie-Christine; Bayard, Sophie

2017-01-01

This study evaluated the validity and reliability of the Montessori Assessment System. The Montessori Assessment System assesses preserved abilities in persons with moderate to severe dementia. In this respect, this instrument provides crucial information for the development of effective person-centered care plans. A total of 196 persons with a diagnosis of dementia in the moderate to severe stages of dementia were recruited in 10 long-term care facilities in France. All participants completed the Montessori Assessment System, the Clinical Dementia Rating Scale and/or the Mini Mental State Examination and the Severe Impairment Battery-short form. The internal consistency and temporal stability of the Montessori Assessment System were high. Additionally, good construct and divergent validity were demonstrated. Factor analysis showed a one-factor structure. The Montessori Assessment System demonstrated satisfactory psychometric properties while being a useful instrument to assess capabilities in persons with advanced stages of dementia and hence to develop person-centered plans of care.

Load theory behind the wheel; perceptual and cognitive load effects.

Science.gov (United States)

Murphy, Gillian; Greene, Ciara M

2017-09-01

Perceptual Load Theory has been proposed as a resolution to the longstanding early versus late selection debate in cognitive psychology. There is much evidence in support of Load Theory but very few applied studies, despite the potential for the model to shed light on everyday attention and distraction. Using a driving simulator, the effect of perceptual and cognitive load on drivers' visual search was assessed. The findings were largely in line with Load Theory, with reduced distractor processing under high perceptual load, but increased distractor processing under high cognitive load. The effect of load on driving behaviour was also analysed, with significant differences in driving behaviour under perceptual and cognitive load. In addition, the effect of perceptual load on drivers' levels of awareness was investigated. High perceptual load significantly increased inattentional blindness and deafness, for stimuli that were both relevant and irrelevant to driving. High perceptual load also increased RTs to hazards. The current study helps to advance Load Theory by illustrating its usefulness outside of traditional paradigms. There are also applied implications for driver safety and roadway design, as the current study suggests that perceptual and cognitive load are important factors in driver attention. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Balancing personalized medicine and personalized care.

Science.gov (United States)

Cornetta, Kenneth; Brown, Candy Gunther

2013-03-01

The current description of personalized medicine by the National Institutes of Health is "the science of individualized prevention and therapy." Although physicians are beginning to see the promise of genetic medicine coming to fruition, the rapid pace of sequencing technology, informatics, and computer science predict a revolution in the ability to care for patients in the near future. The enthusiasm expressed by researchers is well founded, but the expectations voiced by the public do not center on advancing technology. Rather, patients are asking for personalized care: a holistic approach that considers physical, mental, and spiritual well-being. This perspective considers psychological, religious, and ethical challenges that may arise as the precision of preventive medicine improves. Psychological studies already highlight the barriers to single gene testing and suggest significant barriers to the predictive testing envisioned by personalized medicine. Certain religious groups will likely mount opposition if they believe personalized medicine encourages embryo selection. If the technology prompts cost-containment discussions, those concerned about the sanctity of life may raise ethical objections. Consequently, the availability of new scientific developments does not guarantee advances in treatment because patients may prove unwilling to receive and act on personalized genetic information. This perspective highlights current efforts to incorporate personalized medicine and personalized care into the medical curriculum, genetic counseling, and other aspects of clinical practice. Because these efforts are generally independent, the authors offer recommendations for physicians and educators so that personalized medicine can be implemented in a manner that meets patient expectations for personalized care.

Cognitive Load Theory: New Conceptualizations, Specifications, and Integrated Research Perspectives

Science.gov (United States)

Paas, Fred; van Gog, Tamara; Sweller, John

2010-01-01

Over the last few years, cognitive load theory has progressed and advanced rapidly. The articles in this special issue, which document those advances, are based on contributions to the 3rd International Cognitive Load Theory Conference (2009), Heerlen, The Netherlands. The articles of this special issue on cognitive load theory discuss new…

PERSONAL COMPETENCIES, SOCIAL RESOURCES, AND PSYCHOSOCIAL ADJUSTMENT OF PRIMIPAROUS WOMEN OF ADVANCED MATERNAL AGE AND THEIR PARTNERS.

Science.gov (United States)

Guedes, Maryse; Canavarro, Maria Cristina

2015-01-01

The present study aimed to (a) characterize the personal competencies, the social resources, and the psychosocial adjustment (psychological distress, quality of life, and parenting self-perceptions) during the early postpartum period of primiparous women of advanced age (≥35 years at the time of delivery) and their partners (older parents) compared with that of younger first-time mothers (20-34 years) and their partners (younger parents); and (b) explore the role of personal competencies and social resources in couples' psychosocial adjustment, depending on the age group. Older (n = 74) and younger parents (n = 71) completed self-report measures to assess personal competencies and social resources (third trimester of pregnancy), psychological distress, and quality of life (third trimester of pregnancy and 1-month' postpartum) and parenting self-perceptions (1-month' postpartum). Older parents were more similar than different from younger parents regarding personal competencies, social resources, and psychosocial adjustment during the first postnatal month. Regardless of the age group, higher personal competencies and social resources predicted lower anxiety and more positive parenting self-perceptions in women. Beyond higher personal competencies, older maternal age also predicted higher quality of life. In men, higher personal competencies were protective against anxiety, but only at older maternal age. © 2015 Michigan Association for Infant Mental Health.

The meaning and validation of social support networks for close family of persons with advanced cancer.

Science.gov (United States)

Sjolander, Catarina; Ahlstrom, Gerd

2012-09-17

To strengthen the mental well-being of close family of persons newly diagnosed as having cancer, it is necessary to acquire a greater understanding of their experiences of social support networks, so as to better assess what resources are available to them from such networks and what professional measures are required. The main aim of the present study was to explore the meaning of these networks for close family of adult persons in the early stage of treatment for advanced lung or gastrointestinal cancer. An additional aim was to validate the study's empirical findings by means of the Finfgeld-Connett conceptual model for social support. The intention was to investigate whether these findings were in accordance with previous research in nursing. Seventeen family members with a relative who 8-14 weeks earlier had been diagnosed as having lung or gastrointestinal cancer were interviewed. The data were subjected to qualitative latent content analysis and validated by means of identifying antecedents and critical attributes. The meaning or main attribute of the social support network was expressed by the theme Confirmation through togetherness, based on six subthemes covering emotional and, to a lesser extent, instrumental support. Confirmation through togetherness derived principally from information, understanding, encouragement, involvement and spiritual community. Three subthemes were identified as the antecedents to social support: Need of support, Desire for a deeper relationship with relatives, Network to turn to. Social support involves reciprocal exchange of verbal and non-verbal information provided mainly by lay persons. The study provides knowledge of the antecedents and attributes of social support networks, particularly from the perspective of close family of adult persons with advanced lung or gastrointestinal cancer. There is a need for measurement instruments that could encourage nurses and other health-care professionals to focus on family members

Eldercare at Home: Advanced Directives

Science.gov (United States)

... permanently? Helping the person fill out a living will (advance directive) A living will states a person's wishes about medical care if ... never be in a situation where another person will have to make decisions ... it is to have an advance directive. However, don't assume that your loved ...

Racial and Ethnic Differences in Advance Directive Possession: Role of Demographic Factors, Religious Affiliation, and Personal Health Values in a National Survey of Older Adults.

Science.gov (United States)

Huang, Ivy A; Neuhaus, John M; Chiong, Winston

2016-02-01

Black and Hispanic older Americans are less likely than white older Americans to possess advance directives. Understanding the reasons for this racial and ethnic difference is necessary to identify targets for future interventions to improve advance care planning in these populations. The aim of the study was to evaluate whether racial and ethnic differences in advance directive possession are explained by other demographic factors, religious characteristics, and personal health values. A general population survey was conducted in a nationally representative sample using a web-enabled survey panel of American adults aged 50 and older (n = 2154). In a sample of older Americans, white participants are significantly more likely to possess advance directives (44.0%) than black older Americans (24.0%, p personal health values. These findings support targeted efforts to mitigate racial disparities in access to advance care planning.

Load Segmentation for Convergence of Distribution Automation and Advanced Metering Infrastructure Systems

Science.gov (United States)

Pamulaparthy, Balakrishna; KS, Swarup; Kommu, Rajagopal

2014-12-01

Distribution automation (DA) applications are limited to feeder level today and have zero visibility outside of the substation feeder and reaching down to the low-voltage distribution network level. This has become a major obstacle in realizing many automated functions and enhancing existing DA capabilities. Advanced metering infrastructure (AMI) systems are being widely deployed by utilities across the world creating system-wide communications access to every monitoring and service point, which collects data from smart meters and sensors in short time intervals, in response to utility needs. DA and AMI systems convergence provides unique opportunities and capabilities for distribution grid modernization with the DA system acting as a controller and AMI system acting as feedback to DA system, for which DA applications have to understand and use the AMI data selectively and effectively. In this paper, we propose a load segmentation method that helps the DA system to accurately understand and use the AMI data for various automation applications with a suitable case study on power restoration.

Effect of physical property of supporting media and variable hydraulic loading on hydraulic characteristics of advanced onsite wastewater treatment system.

Science.gov (United States)

Sharma, Meena Kumari; Kazmi, Absar Ahmad

2015-01-01

A laboratory-scale study was carried out to investigate the effects of physical properties of the supporting media and variable hydraulic shock loads on the hydraulic characteristics of an advanced onsite wastewater treatment system. The system consisted of two upflow anaerobic reactors (a septic tank and an anaerobic filter) accommodated within a single unit. The study was divided into three phases on the basis of three different supporting media (Aqwise carriers, corrugated ring and baked clay) used in the anaerobic filter. Hydraulic loadings were based on peak flow factor (PFF), varying from one to six, to simulate the actual conditions during onsite wastewater treatment. Hydraulic characteristics of the system were identified on the basis of residence time distribution analyses. The system showed a very good hydraulic efficiency, between 0.86 and 0.93, with the media of highest porosity at the hydraulic loading of PFF≤4. At the higher hydraulic loading of PFF 6 also, an appreciable hydraulic efficiency of 0.74 was observed. The system also showed good chemical oxygen demand and total suspended solids removal efficiency of 80.5% and 82.3%, respectively at the higher hydraulic loading of PFF 6. Plug-flow dispersion model was found to be the most appropriate one to describe the mixing pattern of the system, with different supporting media at variable loading, during the tracer study.

Statistical methods in personality assessment research.

Science.gov (United States)

Schinka, J A; LaLone, L; Broeckel, J A

1997-06-01

Emerging models of personality structure and advances in the measurement of personality and psychopathology suggest that research in personality and personality assessment has entered a stage of advanced development, in this article we examine whether researchers in these areas have taken advantage of new and evolving statistical procedures. We conducted a review of articles published in the Journal of Personality, Assessment during the past 5 years. Of the 449 articles that included some form of data analysis, 12.7% used only descriptive statistics, most employed only univariate statistics, and fewer than 10% used multivariate methods of data analysis. We discuss the cost of using limited statistical methods, the possible reasons for the apparent reluctance to employ advanced statistical procedures, and potential solutions to this technical shortcoming.

Load flow analysis using decoupled fuzzy load flow under critical ...

African Journals Online (AJOL)

user

3.1 Maximum range selection of input and output variables: ..... Wong K. P., Li A., and Law M.Y., “ Advanced Constrained Genetic Algorithm Load Flow Method”, IEE Proc. ... Dr. Parimal Acharjee passed B.E.E. from North Bengal University ...

Freeform electronics for advanced healthcare

KAUST Repository

Hussain, Muhammad Mustafa

2017-02-16

Freeform (physically flexible, stretchable and reconfigurable) electronics can be critical enabler for advanced personalized healthcare. With increased global population and extended average lifetime of mankind, it is more important than ever to integrate advanced electronics into our daily life for advanced personalized healthcare. In this paper, we discuss some critical criteria to design such electronics with enabling applications.

Freeform electronics for advanced healthcare

KAUST Repository

Hussain, Muhammad Mustafa; Hussain, Aftab M.; Nassar, Joanna M.; Kutbee, Arwa T.; Gumus, Abdurrahman; Hanna, Amir

2017-01-01

Freeform (physically flexible, stretchable and reconfigurable) electronics can be critical enabler for advanced personalized healthcare. With increased global population and extended average lifetime of mankind, it is more important than ever to integrate advanced electronics into our daily life for advanced personalized healthcare. In this paper, we discuss some critical criteria to design such electronics with enabling applications.

Controlling Buffeting Loads by Rudder and Piezo-Actuation

Science.gov (United States)

Moses, Robert W.; Pototzky, Anthony S.; Henderson, Douglas A.; Galea, Stephen C.; Manokaran, Donald S.; Zimcik, David G.; Wickramasinghe, Viresh; Pitt, Dale M.; Gamble, Michael A.

2005-01-01

High performance aircraft, especially those with twin vertical tails, encounter unsteady buffet loads when flying at high angles of attack. These stochastic loads result in significant stresses, which may cause fatigue damage leading to restricted capabilities and availability of the aircraft. An international collaborative research activity among Australia, Canada and the United States, conducted under the auspices of The Technical Cooperation Program (TTCP) contributed resources toward a program that coalesced a broad range of technical knowledge and expertise into a single investigation to demonstrate the enhanced performance and capability of the advanced active Buffet Load Alleviation ( ) control system in preparation for a flight test demonstration. The research team investigated the use of active structural control to alleviate the damaging structural response to these loads by applying advanced directional piezoelectric actuators, the aircraft rudder, switch mode amplifiers, and advanced control strategies on an F/A-18 aircraft empennage. Some results of the full-scale investigation are presented herein.

Cognitive load theory: New conceptualizations, specifications, and integrated research perspectives

NARCIS (Netherlands)

G.W.C. Paas (Fred); T.A.J.M. van Gog (Tamara); J. Sweller (John)

2010-01-01

textabstractOver the last few years, cognitive load theory has progressed and advanced rapidly. The articles in this special issue, which document those advances, are based on contributions to the 3rd International Cognitive Load Theory Conference (2009), Heerlen, The Netherlands. The articles of

46 CFR 109.525 - Cranes: Working loads.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Cranes: Working loads. 109.525 Section 109.525 Shipping... Cranes § 109.525 Cranes: Working loads. The master or person in charge shall ensure that tables... working the crane. ...

Hoists having load support in the event of hoist failure

International Nuclear Information System (INIS)

Webb, J.

1984-01-01

A hoist having lifting means for a very heavy load also has rotatable threaded rod load supporters depending from the hoist to which the load is coupled by nuts and arms. The supporters are rotated by a slipping drive so that the nuts try to move in advance of a rise or fall of the load. The advance drive applies a raising or lowering force to the supporters which are free to move axially within small tolerances. At the limit of the tolerances brakes are applied to the rotation of the supporters. In the event of the hoist releasing the load, the load becomes supported by the arms and nuts on the supporters with the supporters firmly braked. (author)

The cryogenic cooling program in high-heat-load optics at the Advanced Photon Source

International Nuclear Information System (INIS)

Rogers, C.S.

1993-07-01

This paper describes some of the aspects of the cryogenic optics program at the Advanced Photon Source (APS). A liquid-nitrogen-cooled, high-vacuum, double crystal monochromator is being fabricated at Argonne National Laboratory (ANL). A pumping system capable of delivering a variable flow rate of up to 10 gallons per minute of pressurized liquid nitrogen and removing 5 kilowatts of x-ray power is also being constructed. This specialized pumping system and monochromator will be used to test the viability of cryogenically cooled, high-heat-load synchrotron optics. It has been determined that heat transfer enhancement will be required for optics used with APS insertion devices. An analysis of a porous-matrix-enhanced monochromator crystal is presented. For the particular case investigated, a heat transfer enhancement factor of 5 to 6 was calculated

The meaning and validation of social support networks for close family of persons with advanced cancer

Directory of Open Access Journals (Sweden)

Sjolander Catarina

2012-09-01

Full Text Available Abstract Background To strengthen the mental well-being of close family of persons newly diagnosed as having cancer, it is necessary to acquire a greater understanding of their experiences of social support networks, so as to better assess what resources are available to them from such networks and what professional measures are required. The main aim of the present study was to explore the meaning of these networks for close family of adult persons in the early stage of treatment for advanced lung or gastrointestinal cancer. An additional aim was to validate the study’s empirical findings by means of the Finfgeld-Connett conceptual model for social support. The intention was to investigate whether these findings were in accordance with previous research in nursing. Methods Seventeen family members with a relative who 8–14 weeks earlier had been diagnosed as having lung or gastrointestinal cancer were interviewed. The data were subjected to qualitative latent content analysis and validated by means of identifying antecedents and critical attributes. Results The meaning or main attribute of the social support network was expressed by the theme Confirmation through togetherness, based on six subthemes covering emotional and, to a lesser extent, instrumental support. Confirmation through togetherness derived principally from information, understanding, encouragement, involvement and spiritual community. Three subthemes were identified as the antecedents to social support: Need of support, Desire for a deeper relationship with relatives, Network to turn to. Social support involves reciprocal exchange of verbal and non-verbal information provided mainly by lay persons. Conclusions The study provides knowledge of the antecedents and attributes of social support networks, particularly from the perspective of close family of adult persons with advanced lung or gastrointestinal cancer. There is a need for measurement instruments that could

Low cognitive load strengthens distractor interference while high load attenuates when cognitive load and distractor possess similar visual characteristics.

Science.gov (United States)

Minamoto, Takehiro; Shipstead, Zach; Osaka, Naoyuki; Engle, Randall W

2015-07-01

Studies on visual cognitive load have reported inconsistent effects of distractor interference when distractors have visual characteristic that are similar to the cognitive load. Some studies have shown that the cognitive load enhances distractor interference, while others reported an attenuating effect. We attribute these inconsistencies to the amount of cognitive load that a person is required to maintain. Lower amounts of cognitive load increase distractor interference by orienting attention toward visually similar distractors. Higher amounts of cognitive load attenuate distractor interference by depleting attentional resources needed to process distractors. In the present study, cognitive load consisted of faces (Experiments 1-3) or scenes (Experiment 2). Participants performed a selective attention task in which they ignored face distractors while judging a color of a target dot presented nearby, under differing amounts of load. Across these experiments distractor interference was greater in the low-load condition and smaller in the high-load condition when the content of the cognitive load had similar visual characteristic to the distractors. We also found that when a series of judgments needed to be made, the effect was apparent for the first trial but not for the second. We further tested an involvement of working memory capacity (WMC) in the load effect (Experiment 3). Interestingly, both high and low WMC groups received an equivalent effect of the cognitive load in the first distractor, suggesting these effects are fairly automatic.

Load Bearing Equipment for Bone and Muscle

Science.gov (United States)

Shackelford, Linda; Griffith, Bryan

2015-01-01

Resistance exercise on ISS has proven effective in maintaining bone mineral density and muscle mass. Exploration missions require exercise with similar high loads using equipment with less mass and volume and greater safety and reliability than resistance exercise equipment used on ISS (iRED, ARED, FWED). Load Bearing Equipment (LBE) uses each exercising person to create and control the load to the partner.

Pediatric Palliative Care: A Personal Story

Medline Plus

Full Text Available ... is starting stop Loading... Watch Queue Queue __count__/__total__ It’s YouTube. Uninterrupted. Loading... Want music and videos with zero ads? Get YouTube Red. Working... Not now Try it free Find out why Close Pediatric Palliative Care: A Personal Story NINRnews Loading... Unsubscribe from NINRnews? ...

Foot loading characteristics during three fencing-specific movements.

Science.gov (United States)

Trautmann, Caroline; Martinelli, Nicolo; Rosenbaum, Dieter

2011-12-01

Plantar pressure characteristics during fencing movements may provide more specific information about the influence of foot loading on overload injury patterns. Twenty-nine experienced fencers participated in the study. Three fencing-specific movements (lunge, advance, retreat) and normal running were performed with three different shoe models: Ballestra (Nike, USA), Adistar Fencing Lo (Adidas, Germany), and the fencers' own shoes. The Pedar system (Novel, Munich, Germany) was used to collect plantar pressures at 50 Hz. Peak pressures, force-time integrals and contact times for five foot regions were compared between four athletic tasks in the lunge leg and supporting leg. Plantar pressure analysis revealed characteristic pressure distribution patterns for the fencing movements. For the lunge leg, during the lunge and advance movements the heel is predominantly loaded; during retreat, it is the hallux. For the supporting leg, during the lunge and advance movements the forefoot is predominantly loaded; during retreat, it is the hallux. Fencing-specific movements load the plantar surface in a distinct way compared with running. An effective cushioning in the heel and hallux region would help to minimize foot loading during fencing-specific movements.

Effect of practice on perceptual load

OpenAIRE

Mejia-Ramirez, Manuel

2013-01-01

Within attention studies, Lavie's load theory (Lavie & Tsal, 1994; Lavie, Hirst, de Fockert, & Viding, 2004) presented an account that could settle the question whether attention selects stimuli to be processed at an early or late stage of cognitive processing. This theory relied on the concepts of "perceptual load" and "attentional capacity", proposing that attentional resources are automatically allocated to stimuli, but when the perceptual load of the stimuli exceeds person's capacity, tas...

Wound healing in immediately loaded implants.

Science.gov (United States)

Romanos, Georgios E

2015-06-01

The orthopedic field has accumulated ample evidence that bone formation is related to functional loading and in general to physical activity. However, despite evidence that immediately loaded implants can be predictably successful, many clinicians still use the classical (delayed loading) treatment protocol. This paper examines the effects of loading on dental implants and discusses the advantages of immediate loading. The role of loading on augmented alveolar ridges is also addressed and provides evidence that early bone resorption may be controlled when bone is functionally loaded. Similar data are emerging for advanced augmentation techniques in order to control crestal bone loss. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

30 CFR 75.1318 - Loading boreholes.

Science.gov (United States)

2010-07-01

... protect persons shall be done in the working place or other area where blasting is to be performed. (c) When loading boreholes drilled at an angle of 45 degrees or greater from the horizontal in solid rock... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Explosives and Blasting § 75.1318 Loading boreholes. (a...

The Genotype-Tissue Expression (GTEx Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine

Directory of Open Access Journals (Sweden)

Judy C. Keen

2015-02-01

Full Text Available Evaluation of how genetic mutations or variability can directly affect phenotypic outcomes, the development of disease, or determination of a tailored treatment protocol is fundamental to advancing personalized medicine. To understand how a genotype affects gene expression and specific phenotypic traits, as well as the correlative and causative associations between such, the Genotype-Tissue Expression (GTEx Project was initiated The GTEx collection of biospecimens and associated clinical data links extensive clinical data with genotype and gene expression data to provide a wealth of data and resources to study the underlying genetics of normal physiology. These data will help inform personalized medicine through the identification of normal variation that does not contribute to disease. Additionally, these data can lead to insights into how gene variation affects pharmacodynamics and individualized responses to therapy.

Long-term Survival of Personalized Surgical Treatment of Locally Advanced Non-small Cell Lung Cancer Based on Molecular Staging

Directory of Open Access Journals (Sweden)

Qinghua ZHOU

2011-02-01

Full Text Available Background and objective Approximately 35%-40% of patients with newly diagnosed non-small cell Lung cancer have locally advanced disease. The average survival time of these patients only have 6-8 months with chemotherapy. The aim of this study is to explore and summarize the probability of detection of micrometastasis in peripheral blood for molecular staging, and for selection of indication of surgical treatment, and beneficiary of neoadjuvant chemotherapy and postoperative adjuvant therapy in locally advanced lung cancer; to summarize the long-time survival result of personalized surgical treatment of 516 patients with locally advanced non-small cell lung cancer based on molecular staging methods. Methods CK19 mRNA expression of peripheral blood samples was detected in 516 lung cancer patients by RT-PCR before operation for molecular diagnosis of micrometastasis, personalized molecular staging, and for selection of indication of surgical treatment and the beneficiary of neoadjuvant chemotherapy and postoperative adjuvant therapy in patients with locally advanced nonsmall cell lung cancer invaded heart, great vessels or both. The long-term survival result of personalized surgical treatment was retrospectively analyzed in 516 patients with locally advanced non-small cell lung cancer based on molecular staging methods. Results There were 322 patients with squamous cell carcinoma and 194 cases with adenocarcinoma in the series of 516 patients with locally advanced lung cancer involved heart, great vessels or both. There were 112 patients with IIIA disease and 404 cases with IIIB disease according to P-TNM staging. There were 97 patients with M-IIIA disease, 278 cases with M-IIIB disease and 141 cases with III disease according to our personalized molecular staging. Of the 516 patients, bronchoplastic procedures and pulmonary artery reconstruction was carried out in 256 cases; lobectomy combined with resection and reconstruction of partial left

Pollution loads in urban runoff and sanitary wastewater.

Science.gov (United States)

Taebi, Amir; Droste, Ronald L

2004-07-05

While more attention has been paid in recent years to urban point source pollution control through the establishment of wastewater treatment plants in many developing countries, no considerable planning nor any serious measures have been taken to control urban non-point source pollution (urban stormwater runoff). The present study is a screening analysis to investigate the pollution loads in urban runoff compared to point source loads as a first prerequisite for planning and management of receiving water quality. To compare pollutant loads from point and non-point urban sources, the pollutant load is expressed as the weight of pollutant per hectare area per year (kg/ha.year). Unit loads were estimated in stormwater runoff, raw sanitary wastewater and secondary treatment effluents in Isfahan, Iran. Results indicate that the annual pollution load in urban runoff is lower than the annual pollution load in sanitary wastewater in areas with low precipitation but it is higher in areas with high precipitation. Two options, namely, advanced treatment (in lieu of secondary treatment) of sanitary wastewater and urban runoff quality control systems (such as detention ponds) were investigated as controlling systems for pollution discharges into receiving waters. The results revealed that for Isfahan, as a low precipitation urban area, advanced treatment is a more suitable option, but for high precipitation urban areas, urban surface runoff quality control installations were more effective for suspended solids and oxygen-demanding matter controls, and that advanced treatment is the more effective option for nutrient control.

Pollution loads in urban runoff and sanitary wastewater

International Nuclear Information System (INIS)

Taebi, Amir; Droste, Ronald L.

2004-01-01

While more attention has been paid in recent years to urban point source pollution control through the establishment of wastewater treatment plants in many developing countries, no considerable planning nor any serious measures have been taken to control urban non-point source pollution (urban stormwater runoff). The present study is a screening analysis to investigate the pollution loads in urban runoff compared to point source loads as a first prerequisite for planning and management of receiving water quality. To compare pollutant loads from point and non-point urban sources, the pollutant load is expressed as the weight of pollutant per hectare area per year (kg/ha·year). Unit loads were estimated in stormwater runoff, raw sanitary wastewater and secondary treatment effluents in Isfahan, Iran. Results indicate that the annual pollution load in urban runoff is lower than the annual pollution load in sanitary wastewater in areas with low precipitation but it is higher in areas with high precipitation. Two options, namely, advanced treatment (in lieu of secondary treatment) of sanitary wastewater and urban runoff quality control systems (such as detention ponds) were investigated as controlling systems for pollution discharges into receiving waters. The results revealed that for Isfahan, as a low precipitation urban area, advanced treatment is a more suitable option, but for high precipitation urban areas, urban surface runoff quality control installations were more effective for suspended solids and oxygen-demanding matter controls, and that advanced treatment is the more effective option for nutrient control

A Mobile-based Platform for Big Load Profiles Data Analytics in Non-Advanced Metering Infrastructures

Directory of Open Access Journals (Sweden)

Moussa Sherin

2016-01-01

Full Text Available With the rapidly increase of electricity demand around the world due to industrialization and urbanization, this turns the availability of precise knowledge about the consumption patterns of consumers to a valuable asset for electricity providers, given the current competitive electricity market. This would allow them to provide satisfactory services in time of load peaks and to control fraud and abuse cases. Despite of this crucial necessity, this is currently very hard to achieve in many developing countries since smart meters or advanced metering infrastructures (AMIs are not yet settled there to monitor and report energy usages. Whereas the communication and information technologies have widely emerged in such nations, allowing the enormous spread of smart devices among population. In this paper, we present mobile-based BLPDA, a novel platform for big data analytics of consumerss’ load profiles (LPs in the absence of AMIs’ establishment. The proposed platform utilizes mobile computing in order to collect the consumptions of consumers, build their LPs, and analyze the aggregated usages data. Thus, allowing electricity providers to have better vision for an enhanced decision making process. The experimental results emphasize the effectiveness of our platform as an adequate alternative for AMIs in developing countries with minimal cost.

Methods of Studying Persons.

Science.gov (United States)

Heinemann, Allen W.; Shontz, Franklin C.

Conventional research strategies typically emphasize behavior-determining tendencies so strongly that the person as a whole is ignored. Research strategies for studying whole persons focus on symbolic structures, formulate specific questions in advance, study persons one at a time, use individualized measures, and regard participants as expert…

The effects of using screencasting as a multimedia pre-training tool to manage the intrinsic cognitive load of chemical equilibrium instruction for advanced high school chemistry students

Science.gov (United States)

Musallam, Ramsey

Chemistry is a complex knowledge domain. Specifically, research notes that Chemical Equilibrium presents greater cognitive challenges than other topics in chemistry. Cognitive Load Theory describes the impact a subject, and the learning environment, have on working memory. Intrinsic load is the facet of Cognitive Load Theory that explains the complexity innate to complex subjects. The purpose of this study was to build on the limited research into intrinsic cognitive load, by examining the effects of using multimedia screencasts as a pre-training technique to manage the intrinsic cognitive load of chemical equilibrium instruction for advanced high school chemistry students. A convenience sample of 62 fourth-year high school students enrolled in an advanced chemistry course from a co-ed high school in urban San Francisco were given a chemical equilibrium concept pre-test. Upon conclusion of the pre-test, students were randomly assigned to two groups: pre-training and no pre-training. The pre-training group received a 10 minute and 52 second pre-training screencast that provided definitions, concepts and an overview of chemical equilibrium. After pre-training both group received the same 50-minute instructional lecture. After instruction, all students were given a chemical equilibrium concept post-test. Independent sample t-tests were conducted to examine differences in performance and intrinsic load. No significant differences in performance or intrinsic load, as measured by ratings of mental effort, were observed on the pre-test. Significant differences in performance, t(60)=3.70, p=.0005, and intrinsic load, t(60)=5.34, p=.0001, were observed on the post-test. A significant correlation between total performance scores and total mental effort ratings was also observed, r(60)=-0.44, p=.0003. Because no significant differences in prior knowledge were observed, it can be concluded that pre-training was successful at reducing intrinsic load. Moreover, a significant

Quality of care for frail older persons in a homecare setting: what is it and how can it be measured?

Science.gov (United States)

Cohen-Mansfield, Jiska; Sela, Adi Hannah; Iecovich, Esther; Golander, Hava

2017-11-02

As more older persons opt to age in place, there is a growing trend to hire migrant workers as live-in caregivers to care for them. This raises the need to examine the quality of care they receive within this unique care setting. The objective of this pilot study was to establish the components of quality of care as provided by migrant live-in caregivers. We interviewed a convenience sample of older persons cared for by migrant live-in caregivers and their relatives. When relatives reported that older persons could not be interviewed due to advanced dementia, only relatives were interviewed. Overall, 72 older persons and 117 relatives were interviewed. We used the Quality of Care Questionnaire (QuCQ) developed for this study to examine the main components of quality of care in this population. Factor analysis using older persons' data revealed two factors. In the first factor, "caretaking," items concerning provision of prompt care exhibited the highest loadings. Items measuring interpersonal aspects of the care dynamic had the highest loadings in the second factor, thus labeled "relationship." The factor analysis based on relatives' data yielded similarities and differences with the one based on older persons' data. Yet, there were significant correlations between relative and older persons' responses when using the older persons' factor structure. According to older persons and relatives, quality of care depends on the extent to which older persons' care-related needs, as well as social ones, are addressed. Appropriate evaluation of quality of care in the live-in setting is important for its improvement.

Advancing E-Commerce Personalization: Process Framework and Case Study

NARCIS (Netherlands)

Kaptein, M.C.; Parvinen, P.

2015-01-01

Personalization is widely used in e-commerce, and as computational power increases, personalization is now within reach for many online vendors. We describe a process framework to structure our knowledge of online personalization both from academia and from applied attempts. This framework is

State of gas exchange in recumbent and orthostatic positions and under physical load in healthy persons of varying age, sex and body build

Science.gov (United States)

Glezer, G. A.; Charyyev, M.; Zilbert, N. L.

1980-01-01

Age effect on gas exchange was studied in the recumbent and orthostatic positions and under physical load. In the case of the older age group and for normal as compared with hypersthenic persons, oxygen consumption during rest and during moderate physical overload diminishes. When the vertical position is assumed oxygen consumption in persons of various age groups is distinctly increased, particularly in the elderly group. There is a reduction in the amount of oxygen consumption, oxygen pulse, recovery coefficient, and work efficiency under moderate overload. In persons over 50, physical labor induces a large oxygen requirement and a sharp rise in the level of lactic acid and the blood's lactate/pyruvate ratio. No distinct difference was noted in the amount of oxygen consumed during rest and during physical overload in men and women of the same physical development and age.

Advancing e-commerce personalization : Process framework and case study

NARCIS (Netherlands)

Kaptein, Maurits; Parvinen, Petri

2015-01-01

Personalization is widely used in e-commerce, and as computational power increases, personalization is now within reach for many online vendors. We describe a process framework to structure our knowledge of online personalization —both from academia and from applied attempts. This framework is

Using personality neuroscience to study personality disorder.

Science.gov (United States)

Abram, Samantha V; DeYoung, Colin G

2017-01-01

Personality neuroscience integrates techniques from personality psychology and neuroscience to elucidate the neural basis of individual differences in cognition, emotion, motivation, and behavior. This endeavor is pertinent not only to our understanding of healthy personality variation, but also to the aberrant trait manifestations present in personality disorders and severe psychopathology. In the current review, we focus on the advances and limitations of neuroimaging methods with respect to personality neuroscience. We discuss the value of personality theory as a means to link specific neural mechanisms with various traits (e.g., the neural basis of the "Big Five"). Given the overlap between dimensional models of normal personality and psychopathology, we also describe how researchers can reconceptualize psychopathological disorders along key dimensions, and, in turn, formulate specific neural hypotheses, extended from personality theory. Examples from the borderline personality disorder literature are used to illustrate this approach. We provide recommendations for utilizing neuroimaging methods to capture the neural mechanisms that underlie continuous traits across the spectrum from healthy to maladaptive. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Multi-axial load application and DIC measurement of advanced composite beam deformation behavior

Directory of Open Access Journals (Sweden)

Berggreen C.

2010-06-01

Full Text Available For the validation of a new beam element formulation, a wide set of experimental data consisting of deformation patterns obtained for a number of specially designed composite beam elements, have been obtained. The composite materials applied in the beams consist of glass-fiber reinforced plastic with specially designed layup configurations promoting advanced coupling behavior. Furthermore, the beams are designed with different cross-section shapes. The data obtained from the experiments are also used in order to improve the general understanding related to practical implementation of mechanisms of elastic couplings due to anisotropic properties of composite materials. The knowledge gained from these experiments is therefore essential in order to facilitate an implementation of passive control in future large wind turbine blades. A test setup based on a four-column MTS servo-hydraulic testing machine with a maximum capacity of 100 kN was developed, see Figure 1. The setup allows installing and testing beams of different cross-sections applying load cases such as axial extension, shear force bending, pure bending in two principal directions as well as pure torsion, see Figure 2. In order to apply multi-axial loading, a load application system consisting of three hydraulic actuators were mounted in two planes using multi-axial servo-hydraulic control. The actuator setup consists of the main actuator on the servo-hydraulic test machine working in the vertical axis (depicted on Figure 1 placed at the testing machine crosshead and used for application of vertical forces to the specimens. Two extra actuators are placed in a horizontal plane on the T-slot table of the test machine in different positions in order to apply loading at the tip of the specimen in various configurations. In order to precisely characterize the global as well as surface deformations of the beam specimens tested, a combination of different measurement systems were used during

A metasynthesis study of family caregivers' transition experiences caring for community-dwelling persons with advanced cancer at the end of life.

Science.gov (United States)

Duggleby, Wendy; Tycholiz, Jamie; Holtslander, Lorraine; Hudson, Peter; Nekolaichuk, Cheryl; Mirhosseini, Mehrnoush; Parmar, Jasneet; Chambers, Thane; Alook, Angele; Swindle, Jennifer

2017-07-01

Family caregivers (broadly defined as family and friends) experience multiple concurrent transitions when caring for a person with advanced cancer. To (a) explore the transition experience of family caregivers caring for persons with advanced cancer living in the community, (b) describe potential triggers for transitions, (c) identify what influences this experience, and (d) develop a conceptual framework of their transition experience. Sandelowski and Barroso's methodology for synthesizing qualitative research included (a) a comprehensive search of empirical literature, (b) quality appraisal of qualitative studies, (c) classification of studies, and (d) synthesis of the findings. Literature was sourced from six electronic data bases. Inclusion criteria were as follows: (a) published qualitative studies (and mixed-method designs) of the caregiving experience of family caregivers of community-living persons with advanced cancer at the end of life, (b) participants (caregivers and care recipients) of 18 years of age and above, (c) studies published in English in any country, and (d) studies published between 2004 and 2014. A total of 72 studies were included in the metasynthesis. Family caregivers experience a "life transition" whereby their lives are permanently altered. The participants described the process of redefining normal which consisted of coming to terms with their situation and connecting with others. Outcomes of these processes were as follows: (a) maintaining a sense of personhood, (b) reframing hope, (c) maintaining self-efficacy, (d) finding meaning, and (e) preparing for the death of their care recipient. The findings provide a framework to guide the development of supportive programs and future research.

3D Numerical Analysis of the Effects of an Advancing Tunnel on an Existing Loaded Pile Group

Directory of Open Access Journals (Sweden)

M. A. Soomro

2018-02-01

Full Text Available Tunnels are often preferred for underground transportation in densely populated areas. In these areas, it is almost inevitable for tunnels to run close to some existing pile foundations. Since tunnelling activities induce stress relief and soil movement in the ground, existing piles may suffer from additional axial and lateral forces, bending moments, settlements and lateral deflections. Most of the previous researches on the responses of pile foundations due to tunnel construction were carried out under the plane strain condition. In this paper, a three-dimensional, elasto-plastic and coupled-consolidation finite element parametric study has been carried out to investigate the effects of a 6 m open-face advancing tunnel on a two by two pile group in saturated stiff clay. The influence of different cover-to-diameter (C/D tunnel ratios (namely 2.0, 2.5 & 3.0 was studied. The objectives of this study are to determine the changes in axial load distribution, changes in shaft resistance along the shaft of pile group and settlement of pile cap due to an advancing open-face tunnel.

Advance Directives of Will (Living Will: Ethical and Legal Implications Based on the Principle of Dignity of Human Person

Directory of Open Access Journals (Sweden)

Maria Aparecida Alkimim

2016-12-01

Full Text Available This paper, with methodology of philosophical, bibliographical and documentary research intends to apply the principle of dignity of human person to the vicissitudes around the advance directives of will, to the ethical aspects disciplined by the Code of Medical Ethics, as well as to what regards the legal aspects, involving the Federal Constitution, the Civil Code, the Code of Medical Ethics and the Resolution 1995/2012 (CFM. The principle of dignity of human person along with the consequent application in the principles of bioethics is considered in a personalistic perspective. This kind of approach is indicative of the interdisciplinarity of bioethics.

Molecular Analysis of Microbial Diversity in Advanced Caries

OpenAIRE

Chhour, Kim-Ly; Nadkarni, Mangala A.; Byun, Roy; Martin, F. Elizabeth; Jacques, Nicholas A.; Hunter, Neil

2005-01-01

Real-time PCR analysis of the total bacterial load in advanced carious lesions has shown that the total load exceeds the number of cultivable bacteria. This suggests that an unresolved complexity exists in bacteria associated with advanced caries. In this report, the profile of the microflora of carious dentine was explored by using DNA extracted from 10 lesions selected on the basis of comparable total microbial load and on the relative abundance of Prevotella spp. Using universal primers fo...

CFD-based design load analysis of 5MW offshore wind turbine

Science.gov (United States)

Tran, T. T.; Ryu, G. J.; Kim, Y. H.; Kim, D. H.

2012-11-01

The structure and aerodynamic loads acting on NREL 5MW reference wind turbine blade are calculated and analyzed based on advanced Computational Fluid Dynamics (CFD) and unsteady Blade Element Momentum (BEM). A detailed examination of the six force components has been carried out (three force components and three moment components). Structure load (gravity and inertia load) and aerodynamic load have been obtained by additional structural calculations (CFD or BEM, respectively,). In CFD method, the Reynolds Average Navier-Stokes approach was applied to solve the continuity equation of mass conservation and momentum balance so that the complex flow around wind turbines was modeled. Written in C programming language, a User Defined Function (UDF) code which defines transient velocity profile according to the Extreme Operating Gust condition was compiled into commercial FLUENT package. Furthermore, the unsteady BEM with 3D stall model has also adopted to investigate load components on wind turbine rotor. The present study introduces a comparison between advanced CFD and unsteady BEM for determining load on wind turbine rotor. Results indicate that there are good agreements between both present methods. It is importantly shown that six load components on wind turbine rotor is significant effect under Extreme Operating Gust (EOG) condition. Using advanced CFD and additional structural calculations, this study has succeeded to construct accuracy numerical methodology to estimate total load of wind turbine that compose of aerodynamic load and structure load.

The Dark Side of Personality: Anti-Sociality Increases Strategic Game Play

OpenAIRE

Engelmann, Jan; Schmid, Basil; Chumbley, Justin; Fehr, Ernst

2018-01-01

We assess the role of anti-social personality traits in explaining heterogeneity in commonly observed social preferences. We identified a personality profile that clearly reflects anti-social personality characteristics, with high positive loadings on Machiavellianism and high negative loadings on empathy, trustworthiness and agreeableness. Anti-sociality predicts decision strategies in a manner that is consistent with its name: significantly lower levels of trust and decreased trustworthines...

LabVIEW Serial Driver Software for an Electronic Load

Science.gov (United States)

Scullin, Vincent; Garcia, Christopher

2003-01-01

A LabVIEW-language computer program enables monitoring and control of a Transistor Devices, Inc., Dynaload WCL232 (or equivalent) electronic load via an RS-232 serial communication link between the electronic load and a remote personal computer. (The electronic load can operate at constant voltage, current, power consumption, or resistance.) The program generates a graphical user interface (GUI) at the computer that looks and acts like the front panel of the electronic load. Once the electronic load has been placed in remote-control mode, this program first queries the electronic load for the present values of all its operational and limit settings, and then drops into a cycle in which it reports the instantaneous voltage, current, and power values in displays that resemble those on the electronic load while monitoring the GUI images of pushbuttons for control actions by the user. By means of the pushbutton images and associated prompts, the user can perform such operations as changing limit values, the operating mode, or the set point. The benefit of this software is that it relieves the user of the need to learn one method for operating the electronic load locally and another method for operating it remotely via a personal computer.

Advanced Power Management of a Telehandler using Electronic Load Sensing

DEFF Research Database (Denmark)

Hansen, Rico Hjerm

2009-01-01

New possibilities within electronic control of mobile hydraulic systems are becoming available as hydraulic components are implemented with more electrical sensors and actuators. This paper presents how the traditional hydro-mechanical load sensing (HLS) control of a specific mobile hydraulic...... application, a telehandler, can be replaced with electronic control, i.e. Electronic Load Sensing (ELS). The motivation for ELS is the potentials of better dynamic performance and system utilization, along with reduced mechanical complexity by transferring features as pump pressure control, flow...

Extracellular vesicles for personalized therapy decision support in advanced metastatic cancers and its potential impact for prostate cancer.

Science.gov (United States)

Soekmadji, Carolina; Corcoran, Niall M; Oleinikova, Irina; Jovanovic, Lidija; Ramm, Grant A; Nelson, Colleen C; Jenster, Guido; Russell, Pamela J

2017-10-01

The use of circulating tumor cells (CTCs) and circulating extracellular vesicles (EVs), such as exosomes, as liquid biopsy-derived biomarkers for cancers have been investigated. CTC enumeration using the CellSearch based platform provides an accurate insight on overall survival where higher CTC counts indicate poor prognosis for patients with advanced metastatic cancer. EVs provide information based on their lipid, protein, and nucleic acid content and can be isolated from biofluids and analyzed from a relatively small volume, providing a routine and non-invasive modality to monitor disease progression. Our pilot experiment by assessing the level of two subpopulations of small EVs, the CD9 positive and CD63 positive EVs, showed that the CD9 positive EV level is higher in plasma from patients with advanced metastatic prostate cancer with detectable CTCs. These data show the potential utility of a particular EV subpopulation to serve as biomarkers for advanced metastatic prostate cancer. EVs can potentially be utilized as biomarkers to provide accurate genotypic and phenotypic information for advanced prostate cancer, where new strategies to design a more personalized therapy is currently the focus of considerable investigation. © 2017 Wiley Periodicals, Inc.

Optimal Control Allocation with Load Sensor Feedback for Active Load Suppression, Flight-Test Performance

Science.gov (United States)

Miller, Christopher J.; Goodrick, Dan

2017-01-01

The problem of control command and maneuver induced structural loads is an important aspect of any control system design. The aircraft structure and the control architecture must be designed to achieve desired piloted control responses while limiting the imparted structural loads. The classical approach is to utilize high structural margins, restrict control surface commands to a limited set of analyzed combinations, and train pilots to follow procedural maneuvering limitations. With recent advances in structural sensing and the continued desire to improve safety and vehicle fuel efficiency, it is both possible and desirable to develop control architectures that enable lighter vehicle weights while maintaining and improving protection against structural damage. An optimal control technique has been explored and shown to achieve desirable vehicle control performance while limiting sensed structural loads to specified values. This technique has been implemented and flown on the National Aeronautics and Space Administration Full-scale Advanced Systems Testbed aircraft. The flight tests illustrate that the approach achieves the desired performance and show promising potential benefits. The flights also uncovered some important issues that will need to be addressed for production application.

Effects of Moderate-Volume, High-Load Lower-Body Resistance Training on Strength and Function in Persons with Parkinson's Disease: A Pilot Study

Directory of Open Access Journals (Sweden)

Brian K. Schilling

2010-01-01

Full Text Available Background. Resistance training research has demonstrated positive effects for persons with Parkinson's disease (PD, but the number of acute training variables that can be manipulated makes it difficult to determine the optimal resistance training program. Objective. The purpose of this investigation was to examine the effects of an 8-week resistance training intervention on strength and function in persons with PD. Methods. Eighteen men and women were randomized to training or standard care for the 8-week intervention. The training group performed 3 sets of 5–8 repetitions of the leg press, leg curl, and calf press twice weekly. Tests included leg press strength relative to body mass, timed up-and-go, six-minute walk, and Activities-specific Balance Confidence questionnaire. Results. There was a significant group-by-time effect for maximum leg press strength relative to body mass, with the training group significantly increasing their maximum relative strength (P.05. Conclusions. Moderate volume, high-load weight training is effective for increasing lower-body strength in persons with PD.

Why doesn't a family member of a person with advanced dementia use a substituted judgment when making a decision for that person?

Science.gov (United States)

Hirschman, Karen B; Kapo, Jennifer M; Karlawish, Jason H T

2006-08-01

The objective of this study was to identify what standard of decision making a family member uses when making medical decisions for their relative with advanced dementia. Thirty family members of patients with advanced dementia from an Alzheimer disease center and a suburban long-term care facility were interviewed using a semistructured interview. All interviews were audiotaped, transcribed, and analyzed using qualitative data analysis techniques. Family members were split almost evenly in the standard they used when making medical decisions for their relative: substituted judgment (43%) or best interests (57%). However, few who used the substituted judgment standard viewed it as distinct from best interests. Instead, both standards were taken into consideration when making medical decisions. In addition to not having discussions about healthcare preferences, the reasons for not using a substituted judgment included: the need for family consensus, unrealistic expectations of the patient, the need to incorporate their relative's quality of life into the decision, and the influence of healthcare professionals. Family members who did not have discussions about healthcare preferences identified various barriers to the discussion, including waiting too long, avoiding the topic, and the patient's denial of dementia. These data suggest several reasons why surrogate decision-makers for persons with advanced dementia do not use the substituted judgment standard and the potential value of interventions that would allow patients with early-stage dementia and their family members to discuss healthcare preferences.

Managing the space-time-load continuum in TMDL planning: a case study for understanding groundwaer loads through advanced mapping techniques

Science.gov (United States)

Phillip Harte; Marcel Belaval; Andrea Traviglia

2016-01-01

The lag time between groundwater recharge and discharge in a watershed and the potential groundwater load to streams is an important factor in forecasting responses to future land use practices. We call this concept managing the “space-time-load continuum.” It’s understood that in any given watershed, the response function (the load at any given time) will differ for...

Nuclear fuel rod loading apparatus

International Nuclear Information System (INIS)

King, H.B.; Macivergan, R.; Mckenzie, G.W.

1980-01-01

An apparatus incorporating a microprocessor control is provided for automatically loading nuclear fuel pellets into fuel rods commonly used in nuclear reactor cores. The apparatus comprises a split ''v'' trough for assembling segments of fuel pellets in rows and a shuttle to receive the fuel pellets from the split ''v'' trough when the two sides of the split ''v'' trough are opened. The pellets are weighed while in the shuttle, and the shuttle then moves the pellets into alignment with a fuel rod. A guide bushing is provided to assist the transfer of the pellets into the fuel rod. A rod carousel which holds a plurality of fuel rods presents the proper rod to the guide bushing at the appropriate stage in the loading sequence. The bushing advances to engage the fuel rod, and the shuttle advances to engage the guide bushing. The pellets are then loaded into the fuel rod by a motor operated push rod. The guide bushing includes a photocell utilized in conjunction with the push rod to measure the length of the row of fuel pellets inserted in the fuel rod

Holomorphic Embedded Load Flow for Autonomous Spacecraft Power Systems, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — The proposed innovation advances the ability to apply the Holomorphic Embedding Load Flow Technology (HELM™) method to provide deterministic load flow modeling for...

Dynamic backcalculation with different load-time histories

DEFF Research Database (Denmark)

Madsen, Stine Skov; Levenberg, Eyal

2017-01-01

This paper focused attention to the falling weight deflectometer (FWD) load-time history. For a commonly used device, it studied the pulse generation mechanism and the influence of different load histories on backcalculation results. In this connection, a semi-analytic impact theory was first...... for an experimental dataset that resulted from operating an FWD with different loading configurations. It was found that backcalculated parameters are sensitive to the FWD pulse features. Consequently, it is recommended that, whenever advanced pavement characterisation is sought, experimental attention should...

Computer-based written emotional disclosure: the effects of advance or real-time guidance and moderation by Big 5 personality traits.

Science.gov (United States)

Beyer, Jonathan A; Lumley, Mark A; Latsch, Deborah V; Oberleitner, Lindsay M S; Carty, Jennifer N; Radcliffe, Alison M

2014-01-01

Standard written emotional disclosure (WED) about stress, which is private and unguided, yields small health benefits. The effect of providing individualized guidance to writers may enhance WED, but has not been tested. This trial of computer-based WED compared two novel therapist-guided forms of WED - advance guidance (before sessions) and real-time guidance (during sessions, through instant messaging) - to both standard WED and control writing; it also tested Big 5 personality traits as moderators of guided WED. Young adult participants (n = 163) with unresolved stressful experiences were randomized to conditions, had three, 30-min computer-based writing sessions, and were reassessed six weeks later. Contrary to hypotheses, real-time guidance WED had poorer outcomes than the other conditions on several measures, and advance guidance WED also showed some poorer outcomes. Moderator analyses revealed that participants with low baseline agreeableness, low extraversion, or high conscientiousness had relatively poor responses to guidance. We conclude that providing guidance for WED, especially in real-time, may interfere with emotional processing of unresolved stress, particularly for people whose personalities have poor fit with this interactive form of WED.

Grid faults' impact on wind turbine structural loads

DEFF Research Database (Denmark)

Hansen, Anca Daniela; Cutululis, Nicolaos Antonio; Iov, F.

2007-01-01

The objective of this work is to illustrate the impact of the grid faults on the wind turbine structural loads. Grid faults are typically simulated in detailed power system simulation tools, which by applying simplified mechanical models, are not able to provide a throughout insight...... on the structural loads caused by sudden disturbances on the grid. On the other hand, structural loads of the wind turbine are typically assessed in advanced aerolastic computer codes, which by applying simplified electrical models do not provide detailed electrical insight. This paper presents a simulation...... strategy, where the focus is on how to access a proper combination of two complimentary simulations tools, such as the advanced aeroelastic computer code HAWC2 and the detailed power system simulation tool DIgSILENT, in order to provide a whole overview of both the structural and the electrical behaviour...

Personalized medicine for non-small-cell lung cancer: implications of recent advances in tissue acquisition for molecular and histologic testing.

Science.gov (United States)

Moreira, Andre L; Thornton, Raymond H

2012-09-01

In light of recent advances in individualized therapy for non-small-cell lung cancer (NSCLC), molecular and histologic profiling is essential for guiding therapeutic decisions. Results of these analyses may have implications for both response (eg, molecular testing for EGFR [epidermal growth factor receptor] mutations) and safety (eg, contraindications for squamous histology) in NSCLC. Most patients with NSCLC present with unresectable advanced disease; therefore, greater emphasis is being placed on minimally invasive tissue acquisition techniques, such as small biopsy and cytology specimens. Due to the need for increasing histologic and molecular information and increasingly smaller tissue sample sizes, efforts must be focused on optimizing tissue acquisition and the development of more sensitive molecular assays. Recent advances in tissue acquisition techniques and specimen preservation may help to address this challenge and lead to enhanced personalized treatment in NSCLC. Copyright © 2012 Elsevier Inc. All rights reserved.

Advancing the Careers of Women with Children

Science.gov (United States)

Metz, Isabel

2005-01-01

Purpose: This study aims to assess whether differences exist in the barriers reported by, and in the person- and situation-centred factors related to the managerial advancement of, women with and without children. The study also seeks to examine whether having children influences womens advancement, by affecting person-situation factors such as…

Novel use of surveillance data to detect HIV-infected persons with sustained high viral load and durable virologic suppression in New York City.

Directory of Open Access Journals (Sweden)

Arpi S Terzian

Full Text Available Monitoring of the uptake and efficacy of ART in a population often relies on cross-sectional data, providing limited information that could be used to design specific targeted intervention programs. Using repeated measures of viral load (VL surveillance data, we aimed to estimate and characterize the proportion of persons living with HIV/AIDS (PLWHA in New York City (NYC with sustained high VL (SHVL and durably suppressed VL (DSVL.Retrospective cohort study of all persons reported to the NYC HIV Surveillance Registry who were alive and ≥12 years old by the end of 2005 and who had ≥2 VL tests in 2006 and 2007. SHVL and DSVL were defined as PLWHA with 2 consecutive VLs ≥100,000 copies/mL and PLWHA with all VLs ≤400 copies/mL, respectively. Logistic regression models using generalized estimating equations were used to model the association between SHVL and covariates. There were 56,836 PLWHA, of whom 7% had SHVL and 38% had DSVL. Compared to those without SHVL, persons with SHVL were more likely to be younger, black and have injection drug use (IDU risk. PLWHA with SHVL were more likely to die by 2007 and be younger by nearly ten years, on average.Nearly 60% of PLWHA in 2005 had multiple VLs, of whom almost 40% had DSVL, suggesting successful ART uptake. A small proportion had SHVL, representing groups known to have suboptimal engagement in care. This group should be targeted for additional outreach to reduce morbidity and secondary transmission. Measures based on longitudinal analyses of surveillance data in conjunction with cross-sectional measures such as community viral load represent more precise and powerful tools for monitoring ART effectiveness and potential impact on disease transmission than cross-sectional measures alone.

Operator dermal exposure and protection provided by personal protective equipment and working coveralls during mixing/loading, application and sprayer cleaning in vineyards.

Science.gov (United States)

Thouvenin, Isabelle; Bouneb, Françoise; Mercier, Thierry

2017-06-01

The efficiency of a working coverall combined with personal protective equipment to protect operators against dermal exposure to plant protection products under field conditions was studied. Operators wore a non-certified water-repellent finish polyester/cotton coverall plus a certified gown during the mixing/loading and the cleaning phases. Insecticide foliar application to a vineyard was selected as the exposure scenario. The overall dermal residue levels measured in this study were in the range of data recently collected in Europe. The water-repellent finish working coverall reduced body exposure by a factor of approximately 95%. Wearing a Category III Type 3 partial body gown during mixing/loading and cleaning of the application equipment led to a further protective effect of 98.7%. The combination of a water-repellent finish working coverall and partial body protection during specific tasks provided satisfactory levels of protection and can be considered as suitable protection for the conditions of use studied.

Social and Personality Development: An Advanced Textbook

Science.gov (United States)

Lamb, Michael E., Ed.; Bornstein, Marc H., Ed.

2011-01-01

This new text contains parts of Bornstein and Lamb's "Developmental Science, 6th edition", along with new introductory material, providing a cutting edge and comprehensive overview of social and personality development. Each of the world-renowned contributors masterfully introduces the history and systems, methodologies, and measurement and…

Personalizing Therapy in Advanced Non–Small Cell Lung Cancer

Science.gov (United States)

Villaruz, Liza C.; Burns, Timothy F.; Ramfidis, Vasilis S.; Socinski, Mark A.

2016-01-01

The recognition that non–small cell lung cancer (NSCLC) is not a single disease entity, but rather a collection of distinct molecularly driven neoplasms, has permanently shifted the therapeutic landscape of NSCLC to a personalized approach. This personalization of NSCLC therapy is typified by the dramatic response rates seen in EGFR mutant NSCLC when treated with targeted tyrosine kinase inhibitor therapy and in ALK translocation–driven NSCLC when treated with ALK inhibitors. Targeted therapeutic approaches in NSCLC necessitate consideration of more invasive biopsy techniques aimed at providing sufficient tissue for both histological determination and molecular profiling in all patients with stage IV disease both at the time of diagnosis and at the time of disease progression. Comprehensive genotyping efforts have identified oncogenic drivers in 62% lung adenocarcinomas and an increasing proportion of squamous cell carcinomas of the lung. The identification of these oncogenic drivers and the triage of patients to clinical trials evaluating novel targeted therapeutic approaches will increasingly mold a landscape of personalized lung cancer therapy where each genotype has an associated targeted therapy. This review outlines the state of personalized lung cancer therapy as it pertains to individual NSCLC genotypes. PMID:24258572

Blending technology in teaching advanced health assessment in a family nurse practitioner program: using personal digital assistants in a simulation laboratory.

Science.gov (United States)

Elliott, Lydia; DeCristofaro, Claire; Carpenter, Alesia

2012-09-01

This article describes the development and implementation of integrated use of personal handheld devices (personal digital assistants, PDAs) and high-fidelity simulation in an advanced health assessment course in a graduate family nurse practitioner (NP) program. A teaching tool was developed that can be utilized as a template for clinical case scenarios blending these separate technologies. Review of the evidence-based literature, including peer-reviewed articles and reviews. Blending the technologies of high-fidelity simulation and handheld devices (PDAs) provided a positive learning experience for graduate NP students in a teaching laboratory setting. Combining both technologies in clinical case scenarios offered a more real-world learning experience, with a focus on point-of-care service and integration of interview and physical assessment skills with existing standards of care and external clinical resources. Faculty modeling and advance training with PDA technology was crucial to success. Faculty developed a general template tool and systems-based clinical scenarios integrating PDA and high-fidelity simulation. Faculty observations, the general template tool, and one scenario example are included in this article. ©2012 The Author(s) Journal compilation ©2012 American Academy of Nurse Practitioners.

Two-Person Technique of Peroral Endoscopic Myotomy for Achalasia with an Advanced Endoscopist and a Thoracic Surgeon: Initial Experience

Directory of Open Access Journals (Sweden)

Madhusudhan R. Sanaka

2016-01-01

Full Text Available Background and Aims. We initiated peroral endoscopic myotomy (POEM utilizing a two-person technique with combination of an advanced endoscopist and a thoracic surgeon with complementary skills. Our aim was to determine the feasibility and outcomes in initial 20 patients. Methods. In this observational study, main outcomes measured were therapeutic success in relieving symptoms (Eckardt score < 3, decrease in lower esophageal sphincter (LES pressures, improvement in emptying on timed barium esophagogram (TBE, and complications. Results. POEM was successful in all 20 patients with a mean operative time of 140.1+32.9 minutes. Eckardt symptom scores decreased significantly at two-month follow-up (6.4+2.9 versus 0.25+0.45, p<0.001. Both basal and residual LES pressures decreased significantly (28.2+14.1 mmHg versus 12.8+6.3 and 22.4+11.3 versus 6.3+3.4 mmHg, p=0.025 and <0.001, resp.. Barium column height at 5 minutes on TBE reduced from 6.8+4.9 cm to 2.3+2.9 cm (p=0.05. Two patients (10% had mucosal perforations and one had delayed bleeding (5%. Conclusions. Two-person technique of POEM with combination of an advanced endoscopist and a thoracic surgeon is highly successful with low risk of complications.

Advanced LBB methodology and considerations

International Nuclear Information System (INIS)

Olson, R.; Rahman, S.; Scott, P.

1997-01-01

LBB applications have existed in many industries and more recently have been applied in the nuclear industry under limited circumstances. Research over the past 10 years has evolved the technology so that more advanced consideration of LBB can now be given. Some of the advanced considerations for nuclear plants subjected to seismic loading evaluations are summarized in this paper

Advanced LBB methodology and considerations

Energy Technology Data Exchange (ETDEWEB)

Olson, R.; Rahman, S.; Scott, P. [Battelle, Columbus, OH (United States)] [and others

1997-04-01

LBB applications have existed in many industries and more recently have been applied in the nuclear industry under limited circumstances. Research over the past 10 years has evolved the technology so that more advanced consideration of LBB can now be given. Some of the advanced considerations for nuclear plants subjected to seismic loading evaluations are summarized in this paper.

Borderline personality disorder traits and their relationship with dimensions of normative personality: a web-based cohort and twin study.

Science.gov (United States)

Kendler, K S; Myers, J; Reichborn-Kjennerud, T

2011-05-01

To describe the structure of genetic and environmental risk factors for four dimensions of borderline personality disorder (BPD) and to understand the source of resemblance of these dimensions and normal personality. A web-based sample (n = 44,112 including 542 twin pairs) completed items from 4 scales of the Dimensional Assessment of Personality Pathology Basic Questionnaire and the Big Five Inventory. A one-factor common pathway model best fits the 4 BPD scales producing a highly heritable latent liability (heritability = 60%) and strong loadings on all 4 dimensions. Affective instability had the lowest trait-specific genetic loading, suggesting that it was a core feature of BPD. A complex pattern of genetic and environmental associations was found between the big five personality traits and BPD dimensions. The strongest genetic correlations with the BPD traits were generally seen for neuroticism (positive), followed by conscientiousness and agreeableness, both negative. In the general population, these four BPD dimensions reflect one underlying highly heritable factor. The association between normative personality and dimensions of BPD is complex with high degrees of genetic correlation. © 2010 John Wiley & Sons A/S.

Advancing E-Commerce Personalization: Process Framework and Case Study

NARCIS (Netherlands)

Kaptein, M.C.; Parvinen, P.

2015-01-01

Personalization is widely used in e-commerce, and as computational power increases, personalization is now within reach for many online vendors. We describe a process framework to structure our knowledge of online personalization both from academia and from applied attempts. This framework is

Advancing e-commerce personalization : Process framework and case study

NARCIS (Netherlands)

Kaptein, Maurits; Parvinen, Petri

2015-01-01

Personalization is widely used in e-commerce, and as computational power increases, personalization is now within reach for many online vendors. We describe a process framework to structure our knowledge of online personalization —both from academia and from applied attempts. This framework is

Composite Materials and Meta Materials for a New Approach to ITER ICRH Loads

International Nuclear Information System (INIS)

Bottollier-Curtet, H.; Argouarch, A.; Vulliez, K.; Becoulet, A.; Litaudon, X.; Magne, R.; Champeaux, S.; Gouard, Ph.; Primout, M.; Le Gallou, J.-H.

2009-01-01

Preliminary laboratory testing of ICRH antennas is a very useful step before their commissioning. Traditionally, pure water, salt water or baking soda water loads are used. These 'water' loads are convenient but strongly limited in terms of performance testing. We have started two feasibility studies for advanced ICRH loads made of ferroelectric ceramics (passive loads) and meta materials (active loads). Preliminary results are very encouraging.

Composite Materials and Meta Materials for a New Approach to ITER ICRH Loads

Science.gov (United States)

Bottollier-Curtet, H.; Argouarch, A.; Champeaux, S.; Gouard, Ph.; Le Gallou, J.-H.; Primout, M.; Vulliez, K.; Bécoulet, A.; Litaudon, X.; Magne, R.

2009-11-01

Preliminary laboratory testing of ICRH antennas is a very useful step before their commissioning. Traditionally, pure water, salt water or baking soda water loads are used. These "water" loads are convenient but strongly limited in terms of performance testing. We have started two feasibility studies for advanced ICRH loads made of ferroelectric ceramics (passive loads) and meta materials (active loads) [1]. Preliminary results are very encouraging.

Long-Haul Truck Sleeper Heating Load Reduction Package for Rest Period Idling

Energy Technology Data Exchange (ETDEWEB)

Lustbader, Jason Aaron; Kekelia, Bidzina; Tomerlin, Jeff; Kreutzer, Cory J.; Yeakel, Skip; Adelman, Steven; Luo, Zhiming; Zehme, John

2016-04-05

Annual fuel use for sleeper cab truck rest period idling is estimated at 667 million gallons in the United States, or 6.8% of long-haul truck fuel use. Truck idling during a rest period represents zero freight efficiency and is largely done to supply accessory power for climate conditioning of the cab. The National Renewable Energy Laboratory's CoolCab project aims to reduce heating, ventilating, and air conditioning (HVAC) loads and resulting fuel use from rest period idling by working closely with industry to design efficient long-haul truck thermal management systems while maintaining occupant comfort. Enhancing the thermal performance of cab/sleepers will enable smaller, lighter, and more cost-effective idle reduction solutions. In addition, if the fuel savings provide a one- to three-year payback period, fleet owners will be economically motivated to incorporate them. For candidate idle reduction technologies to be implemented by original equipment manufacturers and fleets, their effectiveness must be quantified. To address this need, several promising candidate technologies were evaluated through experimentation and modeling to determine their effectiveness in reducing rest period HVAC loads. Load reduction strategies were grouped into the focus areas of solar envelope, occupant environment, conductive pathways, and efficient equipment. Technologies in each of these focus areas were investigated in collaboration with industry partners. The most promising of these technologies were then combined with the goal of exceeding a 30% reduction in HVAC loads. These technologies included 'ultra-white' paint, advanced insulation, and advanced curtain design. Previous testing showed more than a 35.7% reduction in air conditioning loads. This paper describes the overall heat transfer coefficient testing of this advanced load reduction technology package that showed more than a 43% reduction in heating load. Adding an additional layer of advanced insulation

Will and Narrative: Kierkegaard's Notion of the Person

DEFF Research Database (Denmark)

Dalsgaard, Matias Møl

2010-01-01

Within philosophy and psychology the view is today being advanced that the well-being of a person is essentially related to the person's capacity to construct and live out meaningful life narratives. Most notably, thinkers such as Alasdair MacIntyre, Paul Ricoeur and Charles Taylor represent this...... willing to be oneself. In discussing the notion of willing wholeheartedly the paper links Kierkegaard to Harry G. Frankfurt's philosophy of personhood.......Within philosophy and psychology the view is today being advanced that the well-being of a person is essentially related to the person's capacity to construct and live out meaningful life narratives. Most notably, thinkers such as Alasdair MacIntyre, Paul Ricoeur and Charles Taylor represent...

A summary risk score for the prediction of Alzheimer disease in elderly persons.

Science.gov (United States)

Reitz, Christiane; Tang, Ming-Xin; Schupf, Nicole; Manly, Jennifer J; Mayeux, Richard; Luchsinger, José A

2010-07-01

To develop a simple summary risk score for the prediction of Alzheimer disease in elderly persons based on their vascular risk profiles. A longitudinal, community-based study. New York, New York. Patients One thousand fifty-one Medicare recipients aged 65 years or older and residing in New York who were free of dementia or cognitive impairment at baseline. We separately explored the associations of several vascular risk factors with late-onset Alzheimer disease (LOAD) using Cox proportional hazards models to identify factors that would contribute to the risk score. Then we estimated the score values of each factor based on their beta coefficients and created the LOAD vascular risk score by summing these individual scores. Risk factors contributing to the risk score were age, sex, education, ethnicity, APOE epsilon4 genotype, history of diabetes, hypertension or smoking, high-density lipoprotein levels, and waist to hip ratio. The resulting risk score predicted dementia well. According to the vascular risk score quintiles, the risk to develop probable LOAD was 1.0 for persons with a score of 0 to 14 and increased 3.7-fold for persons with a score of 15 to 18, 3.6-fold for persons with a score of 19 to 22, 12.6-fold for persons with a score of 23 to 28, and 20.5-fold for persons with a score higher than 28. While additional studies in other populations are needed to validate and further develop the score, our study suggests that this vascular risk score could be a valuable tool to identify elderly individuals who might be at risk of LOAD. This risk score could be used to identify persons at risk of LOAD, but can also be used to adjust for confounders in epidemiologic studies.

LOW-POWER AC LOADS AND ELECTRICAL POWER QUALITY

Directory of Open Access Journals (Sweden)

EPURE S.

2016-12-01

Full Text Available This paper deals with experimental study and numerical simulation of single phase AC low power loads: artificial light sources, personal computers, refrigeration units, air conditioning units and TV receivers. These loads are in such large numbers that represents the main source of disturbances (harmonic current, reactive power and unbalanced three-phase network. The obtained simulation models, verified by comparison with experimental results may be used in larger simulation models for testing and sizing the optimum parameters of active power filters. Models can also be used to study the interactions between grid elements and various loads or situations.

Life cycle environmental impacts of advanced wastewater treatment techniques for removal of pharmaceuticals and personal care products (PPCPs).

Science.gov (United States)

Zepon Tarpani, Raphael Ricardo; Azapagic, Adisa

2018-06-01

Pharmaceutical and personal care products (PPCPs) are of increasing interest because of their ecotoxicological properties and environmental impacts. Wastewater treatment plants (WWTPs) are the main pathway for their release into freshwaters due to the inefficiency of conventional WWTPs in removing many of these contaminants from effluents. Therefore, different advanced effluent treatment techniques have been proposed for their treatment. However, it is not known at present how effective these treatment methods are and whether on a life cycle basis they cause other environmental impacts which may outweigh the benefits of the treatment. In an effort to provide an insight into this question, this paper considers life cycle environmental impacts of the following advanced treatment techniques aimed at reducing freshwater ecotoxicity potential of PPCPs: granular activated carbon (GAC), nanofiltration (NF), solar photo-Fenton (SPF) and ozonation. The results suggest that on average NF has the lowest impacts for 13 out of 18 categories considered. GAC is the best alternative for five impacts, including metals and water depletion, but it has the highest marine eutrophication. SPF and ozonation are the least sustainable for eight impacts, including ecotoxicity and climate change. GAC and NF are also more efficient in treating heavy metals while avoiding generation of harmful by-products during the treatment, thus being more suitable for potable reuse of wastewater. However, releasing the effluent without advanced treatment to agricultural land achieves a much higher reduction of freshwater ecotoxicity than treating it by any of the advanced treatments and releasing to the environment. Therefore, the use of advanced effluent treatment for agricultural purposes is not recommended. Copyright © 2018 Elsevier Ltd. All rights reserved.

Real-Time Unsteady Loads Measurements Using Hot-Film Sensors

Science.gov (United States)

Mangalam, Arun S.; Moes, Timothy R.

2004-01-01

Several flight-critical aerodynamic problems such as buffet, flutter, stall, and wing rock are strongly affected or caused by abrupt changes in unsteady aerodynamic loads and moments. Advanced sensing and flow diagnostic techniques have made possible simultaneous identification and tracking, in realtime, of the critical surface, viscosity-related aerodynamic phenomena under both steady and unsteady flight conditions. The wind tunnel study reported here correlates surface hot-film measurements of leading edge stagnation point and separation point, with unsteady aerodynamic loads on a NACA 0015 airfoil. Lift predicted from the correlation model matches lift obtained from pressure sensors for an airfoil undergoing harmonic pitchup and pitchdown motions. An analytical model was developed that demonstrates expected stall trends for pitchup and pitchdown motions. This report demonstrates an ability to obtain unsteady aerodynamic loads in real time, which could lead to advances in air vehicle safety, performance, ride-quality, control, and health management.

Advanced interlocking systems to improve heavy-load-bearing characteristics of flexible intramedullary nailing

Energy Technology Data Exchange (ETDEWEB)

Berger, Leopold, E-mail: leopold.berger@tuwien.ac.at [Institute of Building Construction and Technology, TU Wien, Karlsplatz 13/206-4, 1040 Vienna (Austria); Eichler, Johannes [Department of Orthopedics and Orthopedic Surgery, Medical University of Graz, Auenbruggerplatz 5/6, 8036 Graz (Austria); Ryll, E. Jonathan S. [Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, Westphalian-Wilhelms University, Muenster (Germany); Fischerauer, Stefan [Department of Traumatology, Medical University of Graz, Auenbruggerplatz 5/6, 8036 Graz (Austria); Raschke, Michael J. [Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, Westphalian-Wilhelms University, Muenster (Germany); Kolbitsch, Andreas [Institute of Building Construction and Technology, TU Wien, Karlsplatz 13/206-4, 1040 Vienna (Austria); Castellani, Christoph [Department of Pediatric and Adolescence Surgery, Medical University of Graz, Auenbruggerplatz 34, 8036 Graz (Austria); Weinberg, Annelie-Martina [Department of Orthopedics and Orthopedic Surgery, Medical University of Graz, Auenbruggerplatz 5/6, 8036 Graz (Austria)

2016-11-01

Flexible intramedullary nailing (FIN) is a minimally invasive and widespread standard method for osteosynthesis of pediatric long bone fractures. In the case of unstable fractures of the lower extremity, interlocking systems need to be used to prevent axial shortening and subsequent perforation of the nail at its insertion site. In the present study, four different screw-fixed interlocking systems for FINs (Hofer TwinPlug with two 3-mm titanium interlocking screws, Hofer FixPlug with 3-mm titanium interlocking screw, Hofer Plug with 3.5-mm titanium interlocking screw, and Hofer Plug with 3-mm titanium interlocking screw) in comparison with the commonly used Ender stainless steel nails (locked with 3.5-mm screw) were experimentally investigated in cadaveric lamb tibiae, regarding their load characteristics and failure modes in the case of heavy loading. The specimens were subjected to sequential axial cyclic loading of 5000cycles with stepwise increase of the load amplitude until failure. Migration of locking screws and internal damage of bone tissue was quantified by micro-computed tomography (CT) imaging. Ender nails failed on average at a peak load of 800 N, TwinPlugs at 1367 N, FixPlugs at 1222 N, Plugs 3.5mm at 1225 N and Plugs 3.0mm at 971 N. TwinPlugs, FixPlugs, and Plugs 3.5mm failed in a slow manner over several hundred loading cycles, whereas Ender nails and Plugs 3.0mm exhibited abrupt failure without any prior indication. Our results confirm that axial stability of FIN can be further improved by screw-fixed plugs by simultaneously avoiding shortcomings of an eye-locked system, which the Ender nails are. Considering biomechanical results, plug interlocking systems with 3.5-mm screws should be favored over conventional Ender nails and plugs with 3-mm screws. - Highlights: • Locked flexible intramedullary nails in lamb tibiae were cyclically loaded. • Strongly different failure modes of locking systems were detected. • Novel screw-fixed plugs are

Optimal Control Allocation with Load Sensor Feedback for Active Load Suppression, Experiment Development

Science.gov (United States)

Miller, Christopher J.; Goodrick, Dan

2017-01-01

The problem of control command and maneuver induced structural loads is an important aspect of any control system design. The aircraft structure and the control architecture must be designed to achieve desired piloted control responses while limiting the imparted structural loads. The classical approach is to utilize high structural margins, restrict control surface commands to a limited set of analyzed combinations, and train pilots to follow procedural maneuvering limitations. With recent advances in structural sensing and the continued desire to improve safety and vehicle fuel efficiency, it is both possible and desirable to develop control architectures that enable lighter vehicle weights while maintaining and improving protection against structural damage. An optimal control technique has been explored and shown to achieve desirable vehicle control performance while limiting sensed structural loads. The subject of this paper is the design of the optimal control architecture, and provides the reader with some techniques for tailoring the architecture, along with detailed simulation results.

Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Current and advanced act control system definition study

Science.gov (United States)

1982-01-01

The Current and Advanced Technology ACT control system definition tasks of the Integrated Application of Active Controls (IAAC) Technology project within the Energy Efficient Transport Program are summarized. The systems mechanize six active control functions: (1) pitch augmented stability; (2) angle of attack limiting; (3) lateral/directional augmented stability; (4) gust load alleviation; (5) maneuver load control; and (6) flutter mode control. The redundant digital control systems meet all function requirements with required reliability and declining weight and cost as advanced technology is introduced.

The use of collaboration in personal outcomes.

Science.gov (United States)

Callaghan, Leonard

2006-01-01

As part of its restructuring and commitment to collaboration and advances in healthcare, the author's organisation has recently adopted personal outcomes to ensure that services are aligned to meet patient needs more effectively. The purpose of this paper is to evaluate this advancement in healthcare in the light of recent research findings, changing policies and the author's own understanding. DESIGN/METHDODOLOGY/APPROACH: The paper introduces the concept of collaboration as a means of achieving personal outcomes. In addition, the paper puts forward suggestions as to how the nurse can foster interdisciplinary/multidisciplinary teamwork, utilising the core concepts of the advanced nurse practitioner, namely transformational leadership, in support of this. While success stories of personal outcomes abound much of it anecdotal based. Therefore, the need to initiate research in this area is of paramount importance as the latter would be helpful in examining meaningful quality outcomes. Reform in structure, finance and policy will also be necessary, as these are vital ingredients to the success of personal outcomes. Despite the overlapping conflict of Irish government policy, the extra finance announced in the 2005 Budget can only serve to assist organisations in achieving accreditation through initiatives like personal outcomes. Central to the success of personal outcomes, is to engage in collaborative practice by way of fostering interdisciplinary/multidisciplinary team working. Further study of the impact on patient outcomes of collaboration is warranted. The paper examines organisational, professional and interpersonal challenges.

Differential approach to planning of training loads in person with connective tissue dysplasia symptoms

Directory of Open Access Journals (Sweden)

Олег Борисович Неханевич

2015-05-01

Full Text Available Introduction. When dealing with issues of access and planning of training and competitive pressures special interest cause the person with signs of connective tissue dysplasia.Aim. Improvement of medical support of training process of athletes with signs of connective tissue dysplasia.Materials and methods. 188 athletes are examined, including 59 with signs of connective tissue dysplasia. There are made the basic group. Signs of systemic involvement of connective tissue are determined using anthropometry and somatoscopy. An echocardiographic examination is conducted for all athletes at rest and during bicycle ergometry in regenerative period conducted.Results. Underweight body, acromacria, hypermobility of joints and flat feet are often observed with signs of systemic involvement of connective tissue.During veloergometry it was established deterioration of myocardial relaxation during diastole core group of athletes while performing load average power, which led to a drop in ejection fraction at submaximal levels of exertion.Conclusions. Existence of connective tissue dysplasia in athletes with different prognosis states requires sports physicians an in-depth analysis and differential diagnosis of clinical forms in order to prevent complications during training and competitive pressures. Early signs of cardiac strain while performing physical activity in athletes with signs of connective tissue dysplasia were symptoms of myocardial relaxation on indicators of diastolic heart function. Ejection fraction at rest remained at normal levels

Long-Haul Truck Sleeper Heating Load Reduction Package for Rest Period Idling: Preprint

Energy Technology Data Exchange (ETDEWEB)

Lustbader, Jason; Kekelia, Bidzina; Tomerlin, Jeff; Kreutzer, Cory; Adelman, Steve; Yeakel, Skip; Luo, Zhiming; Zehme, John

2016-03-24

Annual fuel use for sleeper cab truck rest period idling is estimated at 667 million gallons in the United States, or 6.8% of long-haul truck fuel use. Truck idling during a rest period represents zero freight efficiency and is largely done to supply accessory power for climate conditioning of the cab. The National Renewable Energy Laboratory's CoolCab project aims to reduce heating, ventilating, and air conditioning (HVAC) loads and resulting fuel use from rest period idling by working closely with industry to design efficient long-haul truck thermal management systems while maintaining occupant comfort. Enhancing the thermal performance of cab/sleepers will enable smaller, lighter, and more cost-effective idle reduction solutions. In addition, if the fuel savings provide a one- to three-year payback period, fleet owners will be economically motivated to incorporate them. For candidate idle reduction technologies to be implemented by original equipment manufacturers and fleets, their effectiveness must be quantified. To address this need, several promising candidate technologies were evaluated through experimentation and modeling to determine their effectiveness in reducing rest period HVAC loads. Load reduction strategies were grouped into the focus areas of solar envelope, occupant environment, conductive pathways, and efficient equipment. Technologies in each of these focus areas were investigated in collaboration with industry partners. The most promising of these technologies were then combined with the goal of exceeding a 30% reduction in HVAC loads. These technologies included 'ultra-white' paint, advanced insulation, and advanced curtain design. Previous testing showed more than a 35.7% reduction in air conditioning loads. This paper describes the overall heat transfer coefficient testing of this advanced load reduction technology package that showed more than a 43% reduction in heating load. Adding an additional layer of advanced insulation

Engaging Students in Active Learning: The Case for Personalized Multimedia Messages.

Science.gov (United States)

Moreno, Roxana; Mayer, Richard E.

2000-01-01

Tests the hypothesis that personalized messages in a multimedia science lesson can promote deep learning by actively engaging students in the elaboration of the materials and reducing processing load. Instructional messages were presented in either a personalized style or a neutral style. Results reveal that personalized messages produced better…

Loads and loads and loads: The influence of prospective load, retrospective load, and ongoing task load in prospective memory

Directory of Open Access Journals (Sweden)

Beat eMeier

2015-06-01

Full Text Available In prospective memory tasks different kinds of load can occur. Adding a prospective memory task can impose a load on ongoing task performance. Adding ongoing task load can affect prospective memory performance. The existence of multiple target events increases prospective load and adding complexity to the to-be-remembered action increases retrospective load. In two experiments, we systematically examined the effects of these different types of load on prospective memory performance. Results showed an effect of prospective load on costs in the ongoing task for categorical targets (Experiment 2, but not for specific targets (Experiment 1. Retrospective load and ongoing task load both affected remembering the retrospective component of the prospective memory task. We suggest that prospective load can enhance costs in the ongoing task due to additional monitoring requirements. Retrospective load and ongoing task load seem to impact the division of resources between the ongoing task and retrieval of the retrospective component, which may affect disengagement from the ongoing task. In general, the results demonstrate that the different types of load affect prospective memory differentially.

IPIRG programs - advances in pipe fracture technology

International Nuclear Information System (INIS)

Wilkowski, G.; Olson, R.; Scott, P.

1997-01-01

This paper presents an overview of the advances made in fracture control technology as a result of the research performed in the International Piping Integrity Research Group (IPIRG) program. The findings from numerous experiments and supporting analyses conducted to investigate the behavior of circumferentially flawed piping and pipe systems subjected to high-rate loading typical of seismic events are summarized. Topics to be discussed include; (1) Seismic loading effects on material properties, (2) Piping system behavior under seismic loads, (3) Advances in elbow fracture evaluations, and (4) open-quotes Realclose quotes piping system response. The presentation for each topic will be illustrated with data and analytical results. In each case, the state-of-the-art in fracture mechanics prior to the first IPIRG program will be contrasted with the state-of-the-art at the completion of the IPIRG-2 program

IPIRG programs - advances in pipe fracture technology

Energy Technology Data Exchange (ETDEWEB)

Wilkowski, G.; Olson, R.; Scott, P. [Batelle, Columbus, OH (United States)

1997-04-01

This paper presents an overview of the advances made in fracture control technology as a result of the research performed in the International Piping Integrity Research Group (IPIRG) program. The findings from numerous experiments and supporting analyses conducted to investigate the behavior of circumferentially flawed piping and pipe systems subjected to high-rate loading typical of seismic events are summarized. Topics to be discussed include; (1) Seismic loading effects on material properties, (2) Piping system behavior under seismic loads, (3) Advances in elbow fracture evaluations, and (4) {open_quotes}Real{close_quotes} piping system response. The presentation for each topic will be illustrated with data and analytical results. In each case, the state-of-the-art in fracture mechanics prior to the first IPIRG program will be contrasted with the state-of-the-art at the completion of the IPIRG-2 program.

Pediatric Palliative Care: A Personal Story

Medline Plus

Full Text Available ... thanks 3-months free Find out why Close Pediatric Palliative Care: A Personal Story NINRnews Loading... Unsubscribe ... This vignette shares the story of Rachel—a pediatric neuroblastoma patient—and her family. The story demonstrates ...

Pediatric Palliative Care: A Personal Story

Medline Plus

Full Text Available ... it free Find out why Close Pediatric Palliative Care: A Personal Story NINRnews Loading... Unsubscribe from NINRnews? ... and her family. The story demonstrates how palliative care can positively influence a patient's and family's experience ...

Pediatric Palliative Care: A Personal Story

Medline Plus

Full Text Available ... Queue Queue __count__/__total__ Find out why Close Pediatric Palliative Care: A Personal Story NINRnews Loading... Unsubscribe ... This vignette shares the story of Rachel—a pediatric neuroblastoma patient—and her family. The story demonstrates ...

Is the relationship between BMI and mortality increasingly U-shaped with advancing age? A 10-year follow-up of persons aged 70-95 years

DEFF Research Database (Denmark)

Thinggaard, Mikael; Jacobsen, Rune; Jeune, Bernard

2010-01-01

BACKGROUND: In the call for papers (Alley DE, Ferrucci L, Barbagallo M, Studenski SA, Harris TB. A research agenda: the changing relationship between body weight and health in aging. J Gerontol A Biol Sci Med Sci. 2008;63(11):1257-1259.), it is assumed that the association between body mass index...... (BMI [kilogram per square meter]) and mortality becomes increasingly U-shaped with advancing age. The aim of this study is to examine the association between BMI and mortality and to test whether the association is changing with advancing age for persons aged 70-95 years in Denmark. METHODS: The study...

Essential elements of the relationship between the nurse and the person with advanced and terminal cancer: A meta-ethnography.

Science.gov (United States)

Errasti-Ibarrondo, Begoña; Pérez, Mercedes; Carrasco, José Miguel; Lama, Marcos; Zaragoza, Amparo; Arantzamendi, María

2015-01-01

The purpose of this study was to understand how the nurse-patient relationship is interpreted by nurses and patients with advanced and terminal cancer (ATC) and which aspects of this relationship are perceived to be the most valuable for patients. A literature search was conducted using the Cumulative Index to Nursing and Allied Health (CINAHL), PubMed, and PsycINFO databases and was supported by reviewing reference lists. Nine articles were selected, and the quality of them was assessed using the Critical Appraisal Skills Program. A synthesis was performed following the seven-stage meta-ethnography described by Noblit and Hare. Four primary themes were derived from the synthesis: (a) being with and being for the person with ATC, (b) time is required for establishing the relationship, (c) the influence of the primary actors in the relationship: the nurse and the person with ATC, and (d) the effects of the relationship on both the nurse and the person with ATC. Finally, an explanatory model of the relationship between the nurse and the patient with ATC was developed, which shows that the relationship is an interpersonal process with several key elements including familiarity with one another, reciprocity, respect, and confidence. The nurses and patients with ATC perceive that their relationship is important and beneficial. The patients demand a helping and caring relationship focused on them as persons, not only as patients. Patients with ATC and nurses consider their relationship to be important and beneficial. An approach to caring focused on patients as persons should be fostered among health care professionals and students. Copyright © 2015 Elsevier Inc. All rights reserved.

30 CFR 77.1602 - Use of aerial tramways to transport persons.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Use of aerial tramways to transport persons. 77.1602 Section 77.1602 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL... UNDERGROUND COAL MINES Loading and Haulage § 77.1602 Use of aerial tramways to transport persons. Persons...

Performance of a 2-megawatt high voltage test load

International Nuclear Information System (INIS)

Horan, D.; Kustom, R.; Ferguson, M.

1995-01-01

A high-power, water-cooled resistive load which simulates the electrical load characteristics of a high-power klystron, capable of 2 megawatts dissipation at 95 kV DC, was built and installed at the Advanced Photon Source for use in load-testing high voltage power supplies. During this testing, the test load has logged approximately 35 hours of operation at power levels in excess of one mezawatt. Slight variations in the resistance of the load during operation indicate that leakage currents in the cooling water may be a significant factor affecting the performance of the load. Sufficient performance data have been collected to indicate that leakage current through the deionized (DI) water coolant shunts roughly 15 percent of the full-load current around the load resistor elements. The leakage current could cause deterioration of internal components of the load. The load pressure vessel was disassembled and inspected internally for any signs of significant wear and distress. Results of this inspection and possible modifications for improved performance will be discussed

Conceptual framework for load controlling : with demand reduction bidding & consumer retention

NARCIS (Netherlands)

Babar, M.; Ahamed, I.; Al-Ammar, E.A.

2013-01-01

Advancement in demand side management strategies enables smart grid to cope with the increasing energy demand and provide economic benefit to all of its stakeholders. Moreover, emerging concept of smart pricing and advances in load control and communication generate new business opportunities as a

Load and Flexibility Models for Distribution Grid Management

DEFF Research Database (Denmark)

Kouzelis, Konstantinos

to advanced metering and control infrastructure investments. These investments will transform distribution networks into smarter" grids which will facilitate flexible load/generation control in return for financial and reliability benefits to electricity consumers. The theoretical idea of modernising the grid...... involve lack of generic load forecasts, need for flexible load/generation estimation techniques from smart meter measurements, deficiencies in online load distribution observability, and, finally, energy market compatible control algorithms which treat consumer flexibility in a fair manner. These modules...... congestions, is proposed. In the first step, a central controller manages flexibility proactively, whereas in the second step a decentralised control scheme deals with flexibility reactively. Both controllers are designed in such a way, that compatibility with contemporary markets is assured, while special...

Personalized Symptom Goals and Patient Global Impression on Clinical Changes in Advanced Cancer Patients.

Science.gov (United States)

Mercadante, Sebastiano; Adile, Claudio; Lanzetta, Gaetano; Mystakidou, Kyriaki; Maltoni, Marco; Soares, Luiz Guilherme; De Santis, Stefano; Ferrera, Patrizia; Valenti, Marco; Rosati, Marta; Rossi, Romina; Cortegiani, Andrea; Masedu, Francesco; Marinangeli, Franco; Aielli, Federica

2018-05-16

The aim of this study was to assess the patients' global impression (PGI) after symptom management, as well as the achievement of personalized symptom goals (PSG). The secondary outcome was to assess related factors. Subjects, Materials, and Methods . Advanced cancer patients admitted to palliative care units rated symptom intensity by using the Edmonton Symptom Assessment Score (ESAS) at admission and then after 1 week. For each symptom, patient-reported PGI and PSG, as well as the rate of PSG response, were evaluated. Eight hundred seventy-six patients were taken into consideration for this study. A mean of 1.71-2.16 points was necessary to perceive a bit better improvement of symptom intensity. Most patients had a PSG of ≤3. A statistically significant number of patients achieved their PSG after starting palliative care. Patients with high intensity of ESAS items at admission achieved a more favorable PGI response. In the multivariate analysis, symptom intensity and PSG were the most frequent factors independently associated to a best PGI, whereas high levels of Karnofsky had a lower odd ratio. PSG and PGI seem to be relevant for patients' assessment and decision-making process, translating in terms of therapeutic intervention. Some factors may be implicated in determining the individual target and clinical response. Personalized symptom goals and global impression of change are relevant for patients' assessment and decision-making process, translating in terms of therapeutic intervention. Some factors may be implicated in determining the individual target and clinical response. © AlphaMed Press 2018.

The paradoxes of application of the legislation on personal data

Directory of Open Access Journals (Sweden)

Natalia A. Bobrova

2018-01-01

Full Text Available The subject. The article is devoted to the analysis of legislation on personal data and it’s enforcement in the educational process in higher educational institutions.The purpose of the article is highlight controversies in legislation on personal data, generating mistakes in enforcement during the educational procedures.The description of methodology. The author uses methods of complex analysis, synthesis, as well as formal-logical and formal-legal methods.The main results and scope of their application. The practice of interpreting the concepts of “personal data”, “confidential personal data”, “official secret”, “publicly available personal data” is extremely contradictory.Currently, there are hundreds departmental regulatory legal acts about various aspects of the protection of official secrets. Analysis of these acts shows that the rules aimed at preserving the confidentiality of official information regulate the following aspects of the functioning of state and municipal bodies, institutions and organizations: (a ensuring access to official information; (b providing state and municipal services; (c document flow and record keeping; (d staffing; (e anti-corruption; (f use of information systems; (g interaction with the media; (h prevention of conflicts of interest.The study load cannot be attributed to the personal data, that requires the consent of the teacher to be processed. The study load is nothing more than publicly available information, arising from the principles of collegiality of educational process management, competitiveness of education, its openness and transparency, that are established in the legislation on education.Conclusions. Extended interpretation of confidential personal data and inclusion of the teaching load to it is unacceptable. This contributes to conflicts of interest, corrupt factors and devaluation of higher education.

Fuel loading and homogeneity analysis of HFIR design fuel plates loaded with uranium silicide fuel

International Nuclear Information System (INIS)

Blumenfeld, P.E.

1995-08-01

Twelve nuclear reactor fuel plates were analyzed for fuel loading and fuel loading homogeneity by measuring the attenuation of a collimated X-ray beam as it passed through the plates. The plates were identical to those used by the High Flux Isotope Reactor (HFIR) but were loaded with uranium silicide rather than with HFIR's uranium oxide fuel. Systematic deviations from nominal fuel loading were observed as higher loading near the center of the plates and underloading near the radial edges. These deviations were within those allowed by HFIR specifications. The report begins with a brief background on the thermal-hydraulic uncertainty analysis for the Advanced Neutron Source (ANS) Reactor that motivated a statistical description of fuel loading and homogeneity. The body of the report addresses the homogeneity measurement techniques employed, the numerical correction required to account for a difference in fuel types, and the statistical analysis of the resulting data. This statistical analysis pertains to local variation in fuel loading, as well as to ''hot segment'' analysis of narrow axial regions along the plate and ''hot streak'' analysis, the cumulative effect of hot segment loading variation. The data for all twelve plates were compiled and divided into 20 regions for analysis, with each region represented by a mean and a standard deviation to report percent deviation from nominal fuel loading. The central regions of the plates showed mean values of about +3% deviation, while the edge regions showed mean values of about -7% deviation. The data within these regions roughly approximated random samplings from normal distributions, although the chi-square (χ 2 ) test for goodness of fit to normal distributions was not satisfied

Robot vision for nuclear advanced robot

International Nuclear Information System (INIS)

Nakayama, Ryoichi; Okano, Hideharu; Kuno, Yoshinori; Miyazawa, Tatsuo; Shimada, Hideo; Okada, Satoshi; Kawamura, Astuo

1991-01-01

This paper describes Robot Vision and Operation System for Nuclear Advanced Robot. This Robot Vision consists of robot position detection, obstacle detection and object recognition. With these vision techniques, a mobile robot can make a path and move autonomously along the planned path. The authors implemented the above robot vision system on the 'Advanced Robot for Nuclear Power Plant' and tested in an environment mocked up as nuclear power plant facilities. Since the operation system for this robot consists of operator's console and a large stereo monitor, this system can be easily operated by one person. Experimental tests were made using the Advanced Robot (nuclear robot). Results indicate that the proposed operation system is very useful, and can be operate by only person. (author)

Development of advanced-RCCA in PWR (2). Design of advanced-RCCA and verification test

Energy Technology Data Exchange (ETDEWEB)

Kitagawa, T.; Naitou, T.; Suzuki, S.; Kawahara, H. [Mitsubishi Heavy Industries Ltd., Kobe (Japan); Tanaka, T. [Kansai Electric Power Co., Inc. (Japan); Kuriyama, H. [Hokkaido Electric Power Co., Inc., Sapporo (Japan); Fujii, S. [Shikoku Electric Power Co., Inc., Takamatsu (Japan); Murakami, S. [Kyusyu Electric Power Co., Inc. (Japan); Murota, M. [Japan Atomic Power Co., Tokyo (Japan)

2001-07-01

Advanced-RCCA enhances control rod worth by adopting boron carbide (B{sub 4}C) with enriched {sup 10}B (hybrid structure B{sub 4}C/Ag-In-Cd). In APWR, advanced-RCCA result in the reduction of the number of RCCA. In conventional PWR, large MOX or high burn-up fuel loading could be introduced without the additional RCCAs. The duplex cladding structure with Cr plating on each outside surface increases the reliability against the RCCA-wear and results in reduction of inspection cost (inspection-equipment, and inspection-interval). Design of advanced-RCCA and verification are also discussed. (author)

24 CFR 891.808 - Capital advance funds.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Capital advance funds. 891.808... Partnerships and Mixed-Finance Development for Supportive Housing for the Elderly or Persons with Disabilities § 891.808 Capital advance funds. (a) HUD is authorized to provide capital advance funds to expand the...

Measuring and Explaining Cognitive Load During Design Activities: A fine-grained approach

DEFF Research Database (Denmark)

Weber, Barbara; Neurauter, Manuel; Burattin, Andrea

2018-01-01

Recent advances in neuro–physiological measurements resulted in reliable and objective measures of Cognitive Load (CL), e.g., using pupillary responses. However, continuous measurement of CL in software design activities, e.g., conceptual modeling, has received little attention. In this paper, we...... present the progress of our work intended to close this gap by continuously measuring cognitive load during design activities. This work aims at advancing our understanding of WHEN and WHY designers face challenges. For this, we attempt to explore and explain the occurrence of CL using fine–granular units...

Personalized medicine in dentistry

Directory of Open Access Journals (Sweden)

Pushpa S Pudakalkatti

2017-01-01

Full Text Available Personalized medicine is a branch of medicine that proposes customization of healthcare in which decisions and treatment are tailored according to individual patient needs. The field of personalized medicine relies on genetic information, proteomic information and clinical patient characteristics to individualize treatment. With advances in genetics, proteomics, pharmacogenetics and knowledgeable patient population, the opportunity exists to deliver never before levels of personalized care. Although general dentists may consider personalized medicine a concept for the future, the reality is that its direct application to everyday dentistry is closer than one might think. Use of personalized medicine in dentistry, especially in periodontology is progressing rapidly, and dentist should consider this approach while treating patients. Google and PubMed search was done to select articles for present review. Total 17 articles were used to compile information.

Revisiting Respect for Persons in Genomic Research

Directory of Open Access Journals (Sweden)

Debra J. H. Mathews

2014-01-01

Full Text Available The risks and benefits of research using large databases of personal information are evolving in an era of ubiquitous, internet-based data exchange. In addition, information technology has facilitated a shift in the relationship between individuals and their personal data, enabling increased individual control over how (and how much personal data are used in research, and by whom. This shift in control has created new opportunities to engage members of the public as partners in the research enterprise on more equal and transparent terms. Here, we consider how some of the technological advances driving and paralleling developments in genomics can also be used to supplement the practice of informed consent with other strategies to ensure that the research process as a whole honors the notion of respect for persons upon which human research subjects protections are premised. Further, we suggest that technological advances can help the research enterprise achieve a more thoroughgoing respect for persons than was possible when current policies governing human subject research were developed. Questions remain about the best way to revise policy to accommodate these changes.

Advancement of a Job- and Personal- Characteristics Placement Model

National Research Council Canada - National Science Library

Frink, Dwight

2001-01-01

Research toward validation of a comprehensive model mapping personal characteristics onto differentiated job characteristics for effective placement, development, and retention of Navy personnel is described...

A Simplified Short Term Load Forecasting Method Based on Sequential Patterns

DEFF Research Database (Denmark)

Kouzelis, Konstantinos; Bak-Jensen, Birgitte; Mahat, Pukar

2014-01-01

Load forecasting is an essential part of a power system both for planning and daily operation purposes. As far as the latter is concerned, short term load forecasting has been broadly used at the transmission level. However, recent technological advancements and legislation have facilitated the i...... in comparison with an ARIMA model....

AdvanceVT Work/Life Policies : Summary Report

OpenAIRE

AdvanceVT

2010-01-01

AdvanceVT’s 2008 Faculty Work/Life Survey showed that 59% of tenured and tenure-track faculty members at Virginia Tech believe it is difficult to have a personal life and earn tenure and 48% feel that their family responsibilities have slowed their career advancement. Female faculty members indicated that they have considered leaving the university in order to obtain better career opportunities for their spouse or partner (43%), as well as to achieve a better personal/professional balance (50...

Personal continuous route pattern mining

Institute of Scientific and Technical Information of China (English)

Qian YE; Ling CHEN; Gen-cai CHEN

2009-01-01

In the daily life, people often repeat regular routes in certain periods. In this paper, a mining system is developed to find the continuous route patterns of personal past trips. In order to count the diversity of personal moving status, the mining system employs the adaptive GPS data recording and five data filters to guarantee the clean trips data. The mining system uses a client/server architecture to protect personal privacy and to reduce the computational load. The server conducts the main mining procedure but with insufficient information to recover real personal routes. In order to improve the scalability of sequential pattern mining, a novel pattern mining algorithm, continuous route pattern mining (CRPM), is proposed. This algorithm can tolerate the different disturbances in real routes and extract the frequent patterns. Experimental results based on nine persons' trips show that CRPM can extract more than two times longer route patterns than the traditional route pattern mining algorithms.

Multi-User Interactive TV: the Next Step in Personalization

NARCIS (Netherlands)

van Brandenburg, Ray; van Deventer, M. Oskar; Karagiannis, Georgios; Schenk, Mike

2010-01-01

In the past few years there has been an increasing trend towards personalization in the TV world. IMS-based IPTV is a good example of a highly personalized IPTV architecture, featuring an advanced identity management subsystem. This article studies a next step in the personalization of the

Advance statements in the new Victorian Mental Health Act.

Science.gov (United States)

Saraf, Sudeep

2015-06-01

There is growing recognition of the utility of advance statements in the area of mental health. The definition of advance statements and procedure for making and varying advance statements under the Victorian legislation is described. The implications for psychiatrists, mental health tribunals and the process should the psychiatrist vary their decision from that made in the advance statement are discussed. Advance statements being enshrined in legislation is another step in the direction of recovery-oriented service provision for persons with mental illness. The challenge for services will be to develop systems and processes that promote increased uptake of these instruments to empower persons with mental illness to participate in their treatment. © The Royal Australian and New Zealand College of Psychiatrists 2015.

Refinements and Tests of an Advanced Controller to Mitigate Fatigue Loads in the Controls Advanced Research Turbine

NARCIS (Netherlands)

Wright, A.D.; Fleming, P.; Van Wingerden, J.W.

2011-01-01

Wind turbines are complex, nonlinear, dynamic systems forced by aerodynamic, gravitational, centrifugal, and gyroscopic loads. The aerodynamics of wind turbines are nonlinear, unsteady, and complex. Turbine rotors are subjected to a complicated 3-D turbulent wind inflow field, with imbedded coherent

Planning sentences while doing other things at the same time: effects of concurrent verbal and visuospatial working memory load.

Science.gov (United States)

Klaus, Jana; Mädebach, Andreas; Oppermann, Frank; Jescheniak, Jörg D

2017-04-01

This study investigated to what extent advance planning during sentence production is affected by a concurrent cognitive load. In two picture-word interference experiments in which participants produced subject-verb-object sentences while ignoring auditory distractor words, we assessed advance planning at a phonological (lexeme) and at an abstract-lexical (lemma) level under visuospatial or verbal working memory (WM) load. At the phonological level, subject and object nouns were found to be activated before speech onset with concurrent visuospatial WM load, but only subject nouns were found to be activated with concurrent verbal WM load, indicating a reduced planning scope as a function of type of WM load (Experiment 1). By contrast, at the abstract-lexical level, subject and object nouns were found to be activated regardless of type of concurrent load (Experiment 2). In both experiments, sentence planning had a more detrimental effect on concurrent verbal WM task performance than on concurrent visuospatial WM task performance. Overall, our results suggest that advance planning at the phonological level is more affected by a concurrently performed verbal WM task than advance planning at the abstract-lexical level. Also, they indicate an overlap of resources allocated to phonological planning in speech production and verbal WM.

Grid faults' impact on wind turbine structural loads

Energy Technology Data Exchange (ETDEWEB)

Hansen, A.D.; Cutululis, N.A.; Soerensen, P.; Larsen, T.J. [Risoe National Lab., DTU, Wind Energy Dept. (Denmark); Iov, F.

2007-11-15

The objective of this work is to illustrate the impact of the grid faults on the wind turbine structural loads. Grid faults are typically in detailed power system simulation tools, which by applying simplified mechanical models, are not able to provide a throughout insight on the structural loads caused by sudden disturbances on the grid. On the other hand, structural loads of the wind turbine are typically assessed in advanced aeroelastic computer codes, which by applying simplified electrical models do not provide detailed electrical insight. This paper presents a simulation strategy, where the focus is on how to access a proper combination of two complementary simulation tools, such as the advanced aeroelastic computer code HAWC2 and the detailed power system simulation tool DIgSILENT, in order to provide a whole overview of both the structural and the electrical behaviour of the wind turbine during grid faults. The effect of a grid fault on the wind turbine flexible structure is assessed for a typical fixed speed wind turbine, equipped with an induction generator. (au)

Advanced testing and characterization of transportation soils and bituminous sands

CSIR Research Space (South Africa)

Anochie-Boateng, Joseph

2007-12-01

Full Text Available This research study was intended to develop laboratory test procedures for advance testing and characterization of fine-grained cohesive soils and oil sand materials. The test procedures are based on typical field loading conditions and the loading...

Personality Assessment: A Competency-Capability Perspective.

Science.gov (United States)

Kaslow, Nadine J; Finklea, J Tyler; Chan, Ginny

2018-01-01

This article begins by reviewing the proficiency of personality assessment in the context of the competencies movement, which has dominated health service psychology in recent years. It examines the value of including a capability framework for advancing this proficiency and enhancing the quality of personality assessments, including Therapeutic Assessment (Finn & Tonsager, 1997 ), that include a personality assessment component. This hybrid competency-capability framework is used to set the stage for the conduct of personality assessments in a variety of contexts and for the optimal training of personality assessment. Future directions are offered in terms of ways psychologists can strengthen their social contract with the public and offer a broader array of personality assessments in more diverse contexts and by individuals who are both competent and capable.

Advances in the Assessment of Wind Turbine Operating Extreme Loads via More Efficient Calculation Approaches

Energy Technology Data Exchange (ETDEWEB)

Graf, Peter; Damiani, Rick R.; Dykes, Katherine; Jonkman, Jason M.

2017-01-09

A new adaptive stratified importance sampling (ASIS) method is proposed as an alternative approach for the calculation of the 50 year extreme load under operational conditions, as in design load case 1.1 of the the International Electrotechnical Commission design standard. ASIS combines elements of the binning and extrapolation technique, currently described by the standard, and of the importance sampling (IS) method to estimate load probability of exceedances (POEs). Whereas a Monte Carlo (MC) approach would lead to the sought level of POE with a daunting number of simulations, IS-based techniques are promising as they target the sampling of the input parameters on the parts of the distributions that are most responsible for the extreme loads, thus reducing the number of runs required. We compared the various methods on select load channels as output from FAST, an aero-hydro-servo-elastic tool for the design and analysis of wind turbines developed by the National Renewable Energy Laboratory (NREL). Our newly devised method, although still in its infancy in terms of tuning of the subparameters, is comparable to the others in terms of load estimation and its variance versus computational cost, and offers great promise going forward due to the incorporation of adaptivity into the already powerful importance sampling concept.

Studies of Personality Disorders

DEFF Research Database (Denmark)

Ronningstam, Elsa; Simonsen, Erik; Oldham, John M

2014-01-01

The past 25 years have shown major advances in the studies of personality disorders. This collaborative article by the presidents, past and present, of ISSPD reflects on the progress within several significant areas of studies, i.e., assessment, neuroscience, treatment, prevention, advocacy...

Advanced secondary batteries: Their applications, technological status, market and opportunity

Science.gov (United States)

Yao, M.

1989-03-01

Program planning for advanced battery energy storage technology is supported within the NEMO Program. Specifically this study had focused on the review of advanced battery applications; the development and demonstration status of leading battery technologies; and potential marketing opportunity. Advanced secondary (or rechargeable) batteries have been under development for the past two decades in the U.S., Japan, and parts of Europe for potential applications in electric utilities and for electric vehicles. In the electric utility applications, the primary aim of a battery energy storage plant is to facilitate peak power load leveling and/or dynamic operations to minimize the overall power generation cost. In the application for peak power load leveling, the battery stores the off-peak base load energy and is discharged during the period of peak power demand. This allows a more efficient use of the base load generation capacity and reduces the need for conventional oil-fired or gas-fire peak power generation equipment. Batteries can facilitate dynamic operations because of their basic characteristics as an electrochemical device capable of instantaneous response to the changing load. Dynamic operating benefits results in cost savings of the overall power plant operation. Battery-powered electric vehicles facilitate conservation of petroleum fuel in the transportation sector, but more importantly, they reduce air pollution in the congested inner cities.

Low-Load Space Conditioning Needs Assessment

Energy Technology Data Exchange (ETDEWEB)

Puttagunta, Srikanth [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States)

2015-05-19

Heating, ventilating, and air-conditioning (HVAC) equipment must be right-sized to ensure energy performance and comfort. With limited low-load options in the HVAC market, many new-construction housing units are being fitted with oversized equipment that creates system efficiency, comfort, and cost penalties. To bridge the gap between currently available HVAC equipment that is oversized or inefficient and the rising demand for low-load HVAC equipment in the marketplace, HVAC equipment manufacturers need to be fully aware of the needs of the multifamily building and attached single-family (duplex and townhouse) home market. Over the past decade, Steven Winter Associates, Inc. (SWA) has provided certification and consulting services for hundreds of housing projects and has accrued a large pool of data that describe multifamily and attached single-family home characteristics. The U.S. Department of Energy’s Building America research team Consortium for Advanced Residential Buildings (CARB) compiled and analyzed these data to outline the characteristics of low-load dwellings such as the heating and cooling design loads.

Relationship between stress coping and personality in patients with major depressive disorder.

Science.gov (United States)

Uehara, T; Sakado, K; Sakado, M; Sato, T; Someya, T

1999-01-01

Stress coping is defined as a behavioral or cognitive response of an individual to uncomfortable or difficult situations. It has been suggested that coping, like personality, is related to the pathology and course of mental disorders. Accordingly, we here used a clinical sample to investigate the relationships between coping strategies and personality traits. Subjects were 60 outpatients who were in remission from major depressive disorder and who completed the Coping Inventory for Stressful Situations (CISS) and the Munich Personality Test (MPT). Task-oriented coping showed a positive correlation with extraversion and frustration tolerance. Emotion-oriented coping was closely associated with neuroticism, esoteric tendencies and isolation tendency. Avoidance-oriented coping was related to extraversion. Principal component analysis indicated three corresponding factors between coping and personality; one was related to psychopathology (loading from the neuroticism, esoteric tendencies and isolation tendency scales of the MPT, and from the emotion-oriented coping scale of the CISS), a second was a social-adaptive ability component (loading from the frustration tolerance and extraversion scales of the MPT, and from the task-oriented coping and avoidance-oriented coping scales of the CISS), and a third was a passive-avoidance coping component (loaded from the emotion-oriented coping and avoidance-oriented coping scales of the CISS only). Some personality traits such as extraversion and frustration tolerance are significantly related to task-oriented coping, and psychopathological personality traits such as neuroticism are associated with emotional-oriented coping in major depressive disorder.

Toward patient-centered, personalized and personal decision support and knowledge management: a survey.

Science.gov (United States)

Leong, T-Y

2012-01-01

This paper summarizes the recent trends and highlights the challenges and opportunities in decision support and knowledge management for patient-centered, personalized, and personal health care. The discussions are based on a broad survey of related references, focusing on the most recent publications. Major advances are examined in the areas of i) shared decision making paradigms, ii) continuity of care infrastructures and architectures, iii) human factors and system design approaches, iv) knowledge management innovations, and v) practical deployment and change considerations. Many important initiatives, projects, and plans with promising results have been identified. The common themes focus on supporting the individual patients who are playing an increasing central role in their own care decision processes. New collaborative decision making paradigms and information infrastructures are required to ensure effective continuity of care. Human factors and usability are crucial for the successful development and deployment of the relevant systems, tools, and aids. Advances in personalized medicine can be achieved through integrating genomic, phenotypic and other biological, individual, and population level information, and gaining useful insights from building and analyzing biological and other models at multiple levels of abstraction. Therefore, new Information and Communication Technologies and evaluation approaches are needed to effectively manage the scale and complexity of biomedical and health information, and adapt to the changing nature of clinical decision support. Recent research in decision support and knowledge management combines heterogeneous information and personal data to provide cost-effective, calibrated, personalized support in shared decision making at the point of care. Current and emerging efforts concentrate on developing or extending conventional paradigms, techniques, systems, and architectures for the new predictive, preemptive, and

Security-Oriented and Load-Balancing Wireless Data Routing Game in the Integration of Advanced Metering Infrastructure Network in Smart Grid

Energy Technology Data Exchange (ETDEWEB)

He, Fulin; Cao, Yang; Zhang, Jun Jason; Wei, Jiaolong; Zhang, Yingchen; Muljadi, Eduard; Gao, Wenzhong

2016-11-21

Ensuring flexible and reliable data routing is indispensable for the integration of Advanced Metering Infrastructure (AMI) networks, we propose a secure-oriented and load-balancing wireless data routing scheme. A novel utility function is designed based on security routing scheme. Then, we model the interactive security-oriented routing strategy among meter data concentrators or smart grid meters as a mixed-strategy network formation game. Finally, such problem results in a stable probabilistic routing scheme with proposed distributed learning algorithm. One contributions is that we studied that different types of applications affect the routing selection strategy and the strategy tendency. Another contributions is that the chosen strategy of our mixed routing can adaptively to converge to a new mixed strategy Nash equilibrium (MSNE) during the learning process in the smart grid.

Recent advances in numerical modeling of detonations

Energy Technology Data Exchange (ETDEWEB)

Mader, C.L.

1986-12-01

Three lectures were presented on recent advances in numerical modeling detonations entitled (1) Jet Initiation and Penetration of Explosives; (2) Explosive Desensitization by Preshocking; (3) Inert Metal-Loaded Explosives.

Intelligent Adaptation and Personalization Techniques in Computer-Supported Collaborative Learning

CERN Document Server

Demetriadis, Stavros; Xhafa, Fatos

2012-01-01

Adaptation and personalization have been extensively studied in CSCL research community aiming to design intelligent systems that adaptively support eLearning processes and collaboration. Yet, with the fast development in Internet technologies, especially with the emergence of new data technologies and the mobile technologies, new opportunities and perspectives are opened for advanced adaptive and personalized systems. Adaptation and personalization are posing new research and development challenges to nowadays CSCL systems. In particular, adaptation should be focused in a multi-dimensional way (cognitive, technological, context-aware and personal). Moreover, it should address the particularities of both individual learners and group collaboration. As a consequence, the aim of this book is twofold. On the one hand, it discusses the latest advances and findings in the area of intelligent adaptive and personalized learning systems. On the other hand it analyzes the new implementation perspectives for intelligen...

Load Composition Model Workflow (BPA TIP-371 Deliverable 1A)

Energy Technology Data Exchange (ETDEWEB)

Chassin, David P.; Cezar, Gustavo V.; /SLAC

2017-07-17

This project is funded under Bonneville Power Administration (BPA) Strategic Partnership Project (SPP) 17-005 between BPA and SLAC National Accelerator Laboratory. The project in a BPA Technology Improvement Project (TIP) that builds on and validates the Composite Load Model developed by the Western Electric Coordinating Council's (WECC) Load Modeling Task Force (LMTF). The composite load model is used by the WECC Modeling and Validation Work Group to study the stability and security of the western electricity interconnection. The work includes development of load composition data sets, collection of load disturbance data, and model development and validation. This work supports reliable and economic operation of the power system. This report was produced for Deliverable 1A of the BPA TIP-371 Project entitled \\TIP 371: Advancing the Load Composition Model". The deliverable documents the proposed work ow for the Composite Load Model, which provides the basis for the instrumentation, data acquisition, analysis and data dissemination activities addressed by later phases of the project.

Skills Required for Nursing Career Advancement: A Qualitative Study.

Science.gov (United States)

Sheikhi, Mohammad Reza; Fallahi-Khoshnab, Masoud; Mohammadi, Farahnaz; Oskouie, Fatemeh

2016-06-01

Nurses require certain skills for progression in their field. Identifying these skills can provide the context for nursing career advancement. This study aimed to identify the skills needed for nurses' career advancement. A qualitative approach using content analysis was adopted to study a purposive sample of eighteen nurses working in teaching hospitals affiliated with the Qazvin, Shahid Beheshti, and Iran Universities of Medical Sciences. The data were collected through semi-structured interviews, and analyzed using conventional content analysis. The three themes extracted from the data included interpersonal capabilities, competency for career success, and personal capacities. The results showed that acquiring a variety of skills is essential for career advancement. The findings showed that personal, interpersonal, and functional skills can facilitate nurses' career advancement. The effects of these skills on career advancement depend on a variety of conditions that require further studies.

Assessment of the transportation route of oversize and excessive loads in relation to the load-bearing capacity of existing bridges

Science.gov (United States)

Doležel, Jiří; Novák, Drahomír; Petrů, Jan

2017-09-01

Transportation routes of oversize and excessive loads are currently planned in relation to ensure the transit of a vehicle through critical points on the road. Critical points are level-intersection of roads, bridges etc. This article presents a comprehensive procedure to determine a reliability and a load-bearing capacity level of the existing bridges on highways and roads using the advanced methods of reliability analysis based on simulation techniques of Monte Carlo type in combination with nonlinear finite element method analysis. The safety index is considered as a main criterion of the reliability level of the existing construction structures and the index is described in current structural design standards, e.g. ISO and Eurocode. An example of a single-span slab bridge made of precast prestressed concrete girders of the 60 year current time and its load bearing capacity is set for the ultimate limit state and serviceability limit state. The structure’s design load capacity was estimated by the full probability nonlinear MKP analysis using a simulation technique Latin Hypercube Sampling (LHS). Load-bearing capacity values based on a fully probabilistic analysis are compared with the load-bearing capacity levels which were estimated by deterministic methods of a critical section of the most loaded girders.

Tapping the energy storage potential in electric loads to deliver load following and regulation, with application to wind energy

International Nuclear Information System (INIS)

Callaway, Duncan S.

2009-01-01

This paper develops new methods to model and control the aggregated power demand from a population of thermostatically controlled loads, with the goal of delivering services such as regulation and load following. Previous work on direct load control focuses primarily on peak load shaving by directly interrupting power to loads. In contrast, the emphasis of this paper is on controlling loads to produce relatively short time scale responses (hourly to sub-hourly), and the control signal is applied by manipulation of temperature set points, possibly via programmable communicating thermostats or advanced metering infrastructure. To this end, the methods developed here leverage the existence of system diversity and use physically-based load models to inform the development of a new theoretical model that accurately predicts - even when the system is not in equilibrium - changes in load resulting from changes in thermostat temperature set points. Insight into the transient dynamics that result from set point changes is developed by deriving a new exact solution to a well-known hybrid state aggregated load model. The eigenvalues of the solution, which depend only on the thermal time constant of the loads under control, are shown to have a strong effect on the accuracy of the model. The paper also shows that load heterogeneity - generally something that must be assumed away in direct load control models - actually has a positive effect on model accuracy. System identification techniques are brought to bear on the problem, and it is shown that identified models perform only marginally better than the theoretical model. The paper concludes by deriving a minimum variance control law, and demonstrates its effectiveness in simulations wherein a population of loads is made to follow the output of a wind plant with very small changes in the nominal thermostat temperature set points.

Body Focused Repetitive Behaviors (BFRBs) and Personality Features

DEFF Research Database (Denmark)

Chamberlain, Samuel; Odlaug, Brian Lawrence

2014-01-01

have they been incorporated into psychiatric nosological systems. The relationship between BFRBs and aspects of personality has been scarcely researched. Understanding how formal axis-II personality disorders, questionnaire-based measures of personality, or other putatively enduring traits...... such as cognitive impairment, relate to the BFRBs may advance our understanding of the core characteristics of the BFRBs and subsequently lead to greater understanding of their pathophysiology and treatment. This article reviews the existing literature surrounding BFRBs and aspects of personality, and highlights...

24 CFR 891.809 - Limitations on capital advance funds.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Limitations on capital advance...-Profit Limited Partnerships and Mixed-Finance Development for Supportive Housing for the Elderly or Persons with Disabilities § 891.809 Limitations on capital advance funds. Capital advances are not...

Neural Mechanism of Inferring Person's Inner Attitude towards Another Person through Observing the Facial Affect in an Emotional Context.

Science.gov (United States)

Kim, Ji-Woong; Kim, Jae-Jin; Jeong, Bumseok; Kim, Sung-Eun; Ki, Seon Wan

2010-03-01

The goal of the present study was to identify the brain mechanism involved in the attribution of person's attitude toward another person, using facial affective pictures and pictures displaying an affectively-loaded situation. Twenty four right-handed healthy subjects volunteered for our study. We used functional magnetic resonance imaging (MRI) to examine brain activation during attitude attribution task as compared to gender matching tasks. We identified activation in the left inferior frontal cortex, left superior temporal sulcus, and left inferior parietal lobule during the attitude attribution task, compared to the gender matching task. This study suggests that mirror neuron system and ventrolateral inferior frontal cortex play a critical role in the attribution of a person's inner attitude towards another person in an emotional situation.

Singing Dialogue : Music therapy with persons in advanced stages of dementia

DEFF Research Database (Denmark)

Ridder, Hanne Mette Ochsner

Persons suffering from primary degenerative dementia at later stages of the disease experience problems in perceiving environmental information and in expressing themselves in verbal language. This leads to difficulties in entering and maintaining dialogue. Failing possibilities of entering...... dialogue, psychosocial needs are not easily fulfilled, which leads to serious secondary symptoms of dementia. In this research the use of familiar songs in music therapy is suggested as a way of entering dialogue, where the communication is adjusted to the individual person. A flexible mixed...... for all six participants; 3) In 5 of 6 concrete cases music therapy shows an influence on aspects in residential daily life, defined in a statistical significant decrease in heart rate levels pre/post therapy, for persons with severe dementia showing agitated behaviour. The participants clearly profit...

Applying a Stiffened Stitched Concept to Shear-Loaded Structure

Science.gov (United States)

Jegley, Dawn C.

2014-01-01

NASA and The Boeing Company have worked to develop new low-cost, lightweight composite structures for aircraft. A stitched carbon-epoxy material system was developed to reduce the weight and cost of transport aircraft structure, first in the NASA Advanced Composites Technology (ACT) Program in the 1990's and now in the Environmentally Responsible Aviation (ERA) Project. By stitching through the thickness of a dry carbon fiber material prior to cure, the need for mechanical fasteners is almost eliminated. Stitching also provides the benefit of reducing or eliminating delaminations, including those between stiffener flanges and skin. The stitched panel concept used in the ACT program used simple blade-stiffeners as stringers, caps, and clips. Today, the Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) concept is being developed for application to advanced vehicle configurations. PRSEUS provides additional weight savings through the use of a stiffener with a thin web and a unidirectional carbon rod at the top of the web which provides structurally efficient stiffening. Comparisons between stitched and unstitched structure and between blade-stiffened and rod-stiffened structure are presented focusing on a panel loaded in shear. Shear loading is representative of spar loading in wing structures.

Advanced High-Level Waste Glass Research and Development Plan

Energy Technology Data Exchange (ETDEWEB)

Peeler, David K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Vienna, John D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Schweiger, Michael J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fox, Kevin M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2015-07-01

The U.S. Department of Energy Office of River Protection (ORP) has implemented an integrated program to increase the loading of Hanford tank wastes in glass while meeting melter lifetime expectancies and process, regulatory, and product quality requirements. The integrated ORP program is focused on providing a technical, science-based foundation from which key decisions can be made regarding the successful operation of the Hanford Tank Waste Treatment and Immobilization Plant (WTP) facilities. The fundamental data stemming from this program will support development of advanced glass formulations, key process control models, and tactical processing strategies to ensure safe and successful operations for both the low-activity waste (LAW) and high-level waste (HLW) vitrification facilities with an appreciation toward reducing overall mission life. The purpose of this advanced HLW glass research and development plan is to identify the near-, mid-, and longer-term research and development activities required to develop and validate advanced HLW glasses and their associated models to support facility operations at WTP, including both direct feed and full pretreatment flowsheets. This plan also integrates technical support of facility operations and waste qualification activities to show the interdependence of these activities with the advanced waste glass (AWG) program to support the full WTP mission. Figure ES-1 shows these key ORP programmatic activities and their interfaces with both WTP facility operations and qualification needs. The plan is a living document that will be updated to reflect key advancements and mission strategy changes. The research outlined here is motivated by the potential for substantial economic benefits (e.g., significant increases in waste throughput and reductions in glass volumes) that will be realized when advancements in glass formulation continue and models supporting facility operations are implemented. Developing and applying advanced

Workshop on high heat load x-ray optics

Energy Technology Data Exchange (ETDEWEB)

1990-01-01

A workshop on High Heat Load X-Ray Optics'' was held at Argonne National Laboratory on August 3--5, 1989. The object of this workshop was to discuss recent advances in the art of cooling x-ray optics subject to high heat loads from synchrotron beams. The cooling of the first optical element in the intense photon beams that will be produced in the next generation of synchrotron sources is recognized as one of the major challenges that must be faced before one will be able to use these very intense beams in future synchrotron experiments. Considerable advances have been made in this art during the last few years, but much work remains to be done before the heating problem can be said to be completely solved. Special emphasis was placed on recent cooling experiments and detailed finite element'' and finite difference'' calculations comparing experiment with theory and extending theory to optimize performance.

Workshop on high heat load x-ray optics

International Nuclear Information System (INIS)

1990-01-01

A workshop on ''High Heat Load X-Ray Optics'' was held at Argonne National Laboratory on August 3--5, 1989. The object of this workshop was to discuss recent advances in the art of cooling x-ray optics subject to high heat loads from synchrotron beams. The cooling of the first optical element in the intense photon beams that will be produced in the next generation of synchrotron sources is recognized as one of the major challenges that must be faced before one will be able to use these very intense beams in future synchrotron experiments. Considerable advances have been made in this art during the last few years, but much work remains to be done before the heating problem can be said to be completely solved. Special emphasis was placed on recent cooling experiments and detailed ''finite element'' and ''finite difference'' calculations comparing experiment with theory and extending theory to optimize performance

Loads and loads and loads: the influence of prospective load, retrospective load, and ongoing task load in prospective memory

Science.gov (United States)

Meier, Beat; Zimmermann, Thomas D.

2015-01-01

In prospective memory tasks different kinds of load can occur. Adding a prospective memory task can impose a load on ongoing task performance. Adding ongoing task load (OTL) can affect prospective memory performance. The existence of multiple target events increases prospective load (PL) and adding complexity to the to-be-remembered action increases retrospective load (RL). In two experiments, we systematically examined the effects of these different types of load on prospective memory performance. Results showed an effect of PL on costs in the ongoing task for categorical targets (Experiment 2), but not for specific targets (Experiment 1). RL and OTL both affected remembering the retrospective component of the prospective memory task. We suggest that PL can enhance costs in the ongoing task due to additional monitoring requirements. RL and OTL seem to impact the division of resources between the ongoing task and retrieval of the retrospective component, which may affect disengagement from the ongoing task. In general, the results demonstrate that the different types of load affect prospective memory differentially. PMID:26082709

Loads and loads and loads: the influence of prospective load, retrospective load, and ongoing task load in prospective memory.

Science.gov (United States)

Meier, Beat; Zimmermann, Thomas D

2015-01-01

In prospective memory tasks different kinds of load can occur. Adding a prospective memory task can impose a load on ongoing task performance. Adding ongoing task load (OTL) can affect prospective memory performance. The existence of multiple target events increases prospective load (PL) and adding complexity to the to-be-remembered action increases retrospective load (RL). In two experiments, we systematically examined the effects of these different types of load on prospective memory performance. Results showed an effect of PL on costs in the ongoing task for categorical targets (Experiment 2), but not for specific targets (Experiment 1). RL and OTL both affected remembering the retrospective component of the prospective memory task. We suggest that PL can enhance costs in the ongoing task due to additional monitoring requirements. RL and OTL seem to impact the division of resources between the ongoing task and retrieval of the retrospective component, which may affect disengagement from the ongoing task. In general, the results demonstrate that the different types of load affect prospective memory differentially.

Microbiological Study on Some Gamma Irradiated Personal Care Products

International Nuclear Information System (INIS)

Ahmed, M.A.Sh.A.

2014-01-01

Humans have a basic need to change their appearance. The vastness of today‟s cosmetics and toiletries industry clearly indicates this wide spread and basic need for personal care products. Perhaps this need arises because these products allow us to make ourselves unique for rituals or societal reasons. We apparently have a primal need for them for our well-being (Geis, 2006). This industry had achieved stupendous growth within a short span of time and is now a multi-billion dollar industry. It would continue to grow as long as people are ready to spend a fortune to look their best. The result of which is large number of brands and twice the number of hair and skin care products (Naz et al., 2012). The term ''personal care products''refers to a wide variety of items find in the health and beauty departments and the products commonly referred to as ''personal care products''are cosmetics (FDA, 2012 a and b). Makeup can do wonders for women, but it can be dangerous to their health, if not handled properly (Archer, 1998 and Persaud, 2008). Practically all cosmetics are subjected to contamination with microorganisms (Oliviera et al., 2013). Contamination leads to several types of infections that range in severity from mild to serious (Ashour et al., 1987). Microbial load of personal care product is affected by the level of contamination during manufacturing, after manufacturing and during consumer use (Razooki et al., 2010 and Muhammed, 2011). The quality of cosmetic products largely depends on the quality of starting materials. The guidelines of good manufacturing practice for cosmetic products (GMPC) have clearly depicted the necessity of the starting materials to comply with specifications (WHO, 1992). Cosmetic contamination awareness is even worse among the younger age. Many women even share makeup and applicators with friends and their family, increasing their chances of facial infection. Makeup can easily be contaminated by the repetitive use to the skin using

Advanced structural wind engineering

CERN Document Server

Kareem, Ahsan

2013-01-01

This book serves as a textbook for advanced courses as it introduces state-of-the-art information and the latest research results on diverse problems in the structural wind engineering field. The topics include wind climates, design wind speed estimation, bluff body aerodynamics and applications, wind-induced building responses, wind, gust factor approach, wind loads on components and cladding, debris impacts, wind loading codes and standards, computational tools and computational fluid dynamics techniques, habitability to building vibrations, damping in buildings, and suppression of wind-induced vibrations. Graduate students and expert engineers will find the book especially interesting and relevant to their research and work.

A modeling and control approach to advanced nuclear power plants with gas turbines

International Nuclear Information System (INIS)

Ablay, Günyaz

2013-01-01

Highlights: • Load frequency control strategies in nuclear plants are researched. • Nuclear reactor-centered control system may not be suitable for load control. • Local unit controllers improve stability and overall time constant. • Coolant loops in nuclear plants should be controlled locally. - Abstract: Advanced nuclear power plants are currently being proposed with a number of various designs. However, there is a lack of modeling and control strategies to deal with load following operations. This research investigates a possible modeling approach and load following control strategy for gas turbine nuclear power plants in order to provide an assessment way to the concept designs. A load frequency control strategy and average temperature control mechanism are studied to get load following nuclear power plants. The suitability of the control strategies and concept designs are assessed through linear stability analysis methods. Numerical results are presented on an advanced molten salt reactor concept as an example nuclear power plant system to demonstrate the validity and effectiveness of the proposed modeling and load following control strategies

Person and consumption profiles. Building integrated energy supply; Person- og forbrugsprofiler. Bygningsintegreret energiforsyning

Energy Technology Data Exchange (ETDEWEB)

Jensen, Rasmus L.; Noergaard, J.; Daniels, O.; Justesen, R.O.

2011-08-15

In the future, buildings will not only act as consumers of energy but as producers as well. For these ''prosumers'', energy production by use of solar panels, photovoltaics and heat pumps etc will be essential. The objective of this project was to find the most optimal combinations of building insulation and use of renewable energy sources in existing buildings in terms of economics and climate impacts. Five houses were analyzed based on different personal load, consumption profiles, solar orientation and proposed building envelope improvements and use of combinations of renewable energy systems. The present report describes how person and consumption profiles used in this project are developed, and which data that form the basis for these profiles. The increasing requirements for energy in the building sector mean that the primary energy consumption ends close to or below zero within the next years. Therefore, the consumption in buildings becomes a relatively larger and larger part of the total energy demand in dwellings. It is important to investigate whether there are seasonal distributions of power and water consumption, because it might give a more exact result and describe the reality better than by using yearly values. First, the personal load determined, and then humidity and consumption of both power and hot water is defined. Second, the hourly profiles are developed based on analyses of seasonal distributions. These profiles also include cold domestic water to see whether there is a correlation between this and hot domestic water. (ln)

Skills Required for Nursing Career Advancement: A Qualitative Study

Science.gov (United States)

Sheikhi, Mohammad Reza; Fallahi-Khoshnab, Masoud; Mohammadi, Farahnaz; Oskouie, Fatemeh

2016-01-01

Background Nurses require certain skills for progression in their field. Identifying these skills can provide the context for nursing career advancement. Objectives This study aimed to identify the skills needed for nurses’ career advancement. Materials and Methods A qualitative approach using content analysis was adopted to study a purposive sample of eighteen nurses working in teaching hospitals affiliated with the Qazvin, Shahid Beheshti, and Iran Universities of Medical Sciences. The data were collected through semi-structured interviews, and analyzed using conventional content analysis. Results The three themes extracted from the data included interpersonal capabilities, competency for career success, and personal capacities. The results showed that acquiring a variety of skills is essential for career advancement. Conclusions The findings showed that personal, interpersonal, and functional skills can facilitate nurses’ career advancement. The effects of these skills on career advancement depend on a variety of conditions that require further studies. PMID:27556054

Personal dosimetry service of VF, a.s. company

International Nuclear Information System (INIS)

Prasek, P.

2009-01-01

The VF, a.s. Company will extend its services in the area of personal dosimetry at the end of 2008, which is fully in compliance with the requirements of the Atomic Act, section 9 paragraph (1) letter r) and Decree on Radiation Protection, section 59 paragraph (1) letter a). Optically stimulated luminescence was selected in VF .a.s. as the most advantageous and the most advanced technology for the integral personal dosimetry. Optically stimulated luminescence (OSL) has been using in dosimetry for more than ten years. Although it is relatively new technology , its indisputable advantages predetermine that technology has significantly benefited in personal dosimetry services within a short time all over the advanced world. The VF, a.s. personal dosimetry service is based on the licensed products of LANDAUER, the US company, which is the world leader in OSL dosimetry. Crystalline Al 2 O 3 :C was selected as the detection material. All equipment of personal dosimetry service is installed in the VF Centre of Technology in Cerna Hora. The personal dosimetry service is incorporated in the International LANDAUER Dosimetry Service Network, and in the European Union, it is directly linked to the LANDAUER European Headquarters with its office in Paris. As a part of the OSL technology licence, the VF personal dosimetry service was included in the inter-laboratory comparison programme of the LANDAUER syndicate. (author)

Personal dosimetry service of VF, a.s. company

International Nuclear Information System (INIS)

Prasek, P.

2008-01-01

The VF, a.s. Company will extend its services in the area of personal dosimetry at the end of 2008, which is fully in compliance with the requirements of the Atomic Act, section 9 paragraph (1) letter r) and Decree on Radiation Protection, section 59 paragraph (1) letter a). Optically stimulated luminescence was selected in VF .a.s. as the most advantageous and the most advanced technology for the integral personal dosimetry . Optically stimulated luminescence (OSL) has been using in dosimetry for more than ten years. Although it is relatively new technology , its indisputable advantages predetermine that technology has significantly benefited in personal dosimetry services within a short time all over the advanced world. The VF, a.s. personal dosimetry service is based on the licensed products of LANDAUER, the US company, which is the world leader in OSL dosimetry. Crystalline Al 2 O 3 :C was selected as the detection material. All equipment of personal dosimetry service is installed in the VF Centre of Technology in Cerna Hora. The personal dosimetry service is incorporated in the International LANDAUER Dosimetry Service Network, and in the European Union, it is directly linked to the LANDAUER European Headquarters with its office in Paris. As a part of the OSL technology licence, the VF personal dosimetry service was included in the inter-laboratory comparison programme of the LANDAUER syndicate. (author)

Greywater characterization and loadings - Physicochemical treatment to promote onsite reuse.

Science.gov (United States)

Noutsopoulos, C; Andreadakis, A; Kouris, N; Charchousi, D; Mendrinou, P; Galani, A; Mantziaras, I; Koumaki, E

2018-06-15

Greywater is the wastewater produced in bathtubs, showers, hand basins, kitchen sinks, dishwashers and laundry machines. Segregation of greywater and blackwater and on site greywater treatment in order to promote its reuse for toilet flushing and/or garden irrigation is an interesting option especially in water deficient areas. The objective of this study was to characterize the different greywater sources in Greek households and to evaluate the performance of alternative physicochemical treatment systems to treat several types of greywater. Based on the results average daily greywater production was equal to 98 L per person per day and accounts for approximately 70-75% of the total household wastewater production (135 L per person per day). Among the different sources, laundry and kitchen sink are the main contributors to the total greywater load of organic carbon, suspended solids and surfactants, whereas dishwasher and bathroom greywater are the main sources of phosphorus and endocrine disrupting chemicals respectively. Depending on sources, greywater accounts for as low as 15% of the total wastewater load of organic carbon (in the case of light greywater sources), to as high as 74% of the total load organic load (in the case of the heavy greywater sources). On the other hand, the nutrients load of greywater is limited. The application of a physical treatment system consisting of coagulation, sedimentation, sand filtration, granular activated carbon filtration and disinfection can provide for a final effluent with high quality characteristics for onsite reuse, especially when treating light greywater. Copyright © 2017 Elsevier Ltd. All rights reserved.

Students' Scientific Epistemic Beliefs, Online Evaluative Standards, and Online Searching Strategies for Science Information: The Moderating Role of Cognitive Load Experience

Science.gov (United States)

Hsieh, Ya-Hui; Tsai, Chin-Chung

2014-06-01

The purpose of this study is to examine the moderating role of cognitive load experience between students' scientific epistemic beliefs and information commitments, which refer to online evaluative standards and online searching strategies. A total of 344 science-related major students participated in this study. Three questionnaires were used to ascertain the students' scientific epistemic beliefs, information commitments, and cognitive load experience. Structural equation modeling was then used to analyze the moderating effect of cognitive load, with the results revealing its significant moderating effect. The relationships between sophisticated scientific epistemic beliefs and the advanced evaluative standards used by the students were significantly stronger for low than for high cognitive load students. Moreover, considering the searching strategies that the students used, the relationships between sophisticated scientific epistemic beliefs and advanced searching strategies were also stronger for low than for high cognitive load students. However, for the high cognitive load students, only one of the sophisticated scientific epistemic belief dimensions was found to positively associate with advanced evaluative standard dimensions.

Advanced Internet Protocols, Services, and Applications

CERN Document Server

Oki, Eiji; Tatipamula, Mallikarjun; Vogt, Christian

2012-01-01

Today, the internet and computer networking are essential parts of business, learning, and personal communications and entertainment. Virtually all messages or transactions sent over the internet are carried using internet infrastructure- based on advanced internet protocols. Advanced internet protocols ensure that both public and private networks operate with maximum performance, security, and flexibility. This book is intended to provide a comprehensive technical overview and survey of advanced internet protocols, first providing a solid introduction and going on to discu

Surface loading of a viscoelastic earth-I. General theory

Science.gov (United States)

Tromp, Jeroen; Mitrovica, Jerry X.

1999-06-01

We present a new normal-mode formalism for computing the response of an aspherical, self-gravitating, linear viscoelastic earth model to an arbitrary surface load. The formalism makes use of recent advances in the theory of the Earth's free oscillations, and is based upon an eigenfunction expansion methodology, rather than the tradi-tional Love-number approach to surface-loading problems. We introduce a surface-load representation theorem analogous to Betti's reciprocity relation in seismology. Taking advantage of this theorem and the biorthogonality of the viscoelastic modes, we determine the complete response to a surface load in the form of a Green's function. We also demonstrate that each viscoelastic mode has its own unique energy partitioning, which can be used to characterize it. In subsequent papers, we apply the theory to spherically symmetric and aspherical earth models.

Personalized medicine and ethics.

Science.gov (United States)

Josko, Deborah

2014-01-01

An entire series could be dedicated to the topic of ethics in personalized medicine. Due to the advancements in NGS and genetic testing, personalized medicine is no longer something that will occur in the future, the reality is upon us now. Sequencing an individual's genome can have a substantial impact on the patient's treatment and overall quality of life. However, this can open "Pandora's box" especially if an individual does not want to know the information obtained. In addition, will insurance companies require genetic testing in order to pay for a targeted treatment? If the patient refuses to have the genetic testing, will they have to pay for their treatment out of pocket? In the human interest story presented, the researcher and his team discovered over activity of the FTL3 protein through RNA sequencing which resulted in rapid proliferation of his leukemic cells. He identified a drug marketed for advanced kidney cancer which was a FTL3 inhibitor. However, his insurance company refused to pay for the drug because it was not a known treatment for his condition of ALL. He incurred numerous out of pocket expenses in order to go into remission. Was it unethical for the insurance company to not pay for a treatment that ultimately worked but was not marketed or FDA cleared for his type of leukemia? There are so many questions and concerns when personalized medicine is implemented. Only time will tell the effects next generation sequencing and its role in personalized medicine will have in the future.

Car transfer and wheelchair loading techniques in independent drivers with paraplegia

Directory of Open Access Journals (Sweden)

Lisa Lighthall Haubert

2015-09-01

Full Text Available Car transfers and wheelchair (WC loading are crucial for independent community participation in persons with complete paraplegia from spinal cord injury, but are complex, physically demanding, and known to provoke shoulder pain. This study aimed to describe techniques and factors influencing car transfer and WC loading for individuals with paraplegia driving their own vehicles and using their personal WCs. Sedans were the most common vehicle driven (59%. Just over half (52% of drivers place their right leg only into the vehicle prior to transfer. Overall, the leading hand was most frequently placed on the driver’s seat (66% prior to transfer and the trailing hand was most often place on the WC seat (48%. Vehicle height influenced leading hand placement but not leg placement such that driver’s of higher profile vehicles were more likely to place their hand on the driver’s seat than those who drove sedans. Body lift time was negatively correlated with level of injury and age and positively correlated with vehicle height and shoulder abduction strength. Drivers who transferred with their leading hand on the steering wheel had significantly higher levels of shoulder pain than those who placed their hand on the driver’s seat or overhead. The majority of participants used both hands (62% to load their WC frame and, overall, most loaded their fame into the back (62% vs. the front seat. Sedan drivers were more likely to load their frame into the front seat than drivers of higher profile vehicles (53% vs. 17%. Average time to load the WC frame (10.7 seconds was 20% of the total WC loading time and was not related to shoulder strength, frame weight or demographic characteristics. Those who loaded their WC frame into the back seat had significantly weaker right shoulder internal rotators. Understanding car transfers and WC loading in independent drivers is crucial to prevent shoulder pain and injury and preserve community participation.

Technological advances in precision medicine and drug development.

Science.gov (United States)

Maggi, Elaine; Patterson, Nicole E; Montagna, Cristina

New technologies are rapidly becoming available to expand the arsenal of tools accessible for precision medicine and to support the development of new therapeutics. Advances in liquid biopsies, which analyze cells, DNA, RNA, proteins, or vesicles isolated from the blood, have gained particular interest for their uses in acquiring information reflecting the biology of tumors and metastatic tissues. Through advancements in DNA sequencing that have merged unprecedented accuracy with affordable cost, personalized treatments based on genetic variations are becoming a real possibility. Extraordinary progress has been achieved in the development of biological therapies aimed to even further advance personalized treatments. We provide a summary of current and future applications of blood based liquid biopsies and how new technologies are utilized for the development of biological therapeutic treatments. We discuss current and future sequencing methods with an emphasis on how technological advances will support the progress in the field of precision medicine.

Research on loading pattern optimization for VVER reactor

International Nuclear Information System (INIS)

Tran Viet Phu; Nguyen Thi Mai Huong; Nguyen Huu Tiep; Ta Duy Long; Tran Vinh Thanh; Tran Hoai Nam

2017-01-01

A study on fuel loading pattern optimization of a VVER reactor was performed. In this study, a core physics simulator was developed based on a multi-group diffusion theory for the use in the problem of fuel loading optimization of VVER reactors. The core simulator could handle the triangular meshes of the core and the computational speed is fast. Verification of the core simulator was confirmed against a benchmark problem of a VVER-1000 reactor. Several optimization methods such as DS, SA, TS and a combination of them were investigated and implemented in coupling with the core simulator. Calculations was performed for optimizing the fuel loading pattern of the core using these methods based on a benchmark core model in comparison with the reference core. Comparison among these methods have shown that a combination of SA+TS is the most effective for the problem of fuel loading pattern optimization. Advanced methods are being researched continuously. (author)

Contributions from personality- and psychodynamically oriented assessment to the development of the DSM-5 personality disorders.

Science.gov (United States)

Huprich, Steven K

2011-07-01

Advances in personality assessment over the past 20 years have notably influenced the proposed assessment and classification of personality disorders in the Diagnostic and Statistical Manual of Mental Disorders (5th ed. [DSM-5]). However, a considerable body of personality assessment and psychodynamically oriented assessment research has significant relevance to the way in which personality disorders are evaluated that appears to have gone unrecognized in the current proposals for DSM-5. In this article, I discuss the ways in which some of these 2 bodies of literature can and should inform the DSM-5 so that the diagnostic nomenclature can be more scientifically and comprehensively informed and consequently improve the clinical utility of a diagnostic system in need of considerable revision.

’Cause You’ve Got Personality

Directory of Open Access Journals (Sweden)

Aaron Weinschenk

2013-10-01

Full Text Available The integration of the Big Five personality traits into models of political participation represents an important advance in the political behavior literature. However, because national surveys that include political and personality measures are not widespread, such analyses have been limited in number. In addition, there have been inconsistencies within and across studies on personality and participation. The availability of more data make it possible to compare the performance of personality measurement batteries across recent political surveys, reexamine hypotheses about the link between personality and participation, test the explanatory power of personality across samples and in different contexts, and expand measures of political and civic engagement, all of which I do in this article. Personality traits do influence political participation, although the magnitude and direction of effects depend on the particular act. Extraversion has a consistent effect on participation, but the effects of Agreeableness, Openness, Conscientiousness, and Emotional Stability are much less consistent.

Development of advanced PWR steam generator

International Nuclear Information System (INIS)

Saito, Itaru; Nakamura, Tomomichi

1999-01-01

In response to the increased power of the advanced PWR, it is necessary to develop a steam generator (SG) which has a large capacity with high performance and high reliability as well as being economical to produce. In this paper, the development of the design of a new SG for the advanced PWRs is described and compared with the design of a conventional SG. Moreover, an outline of a seismic verification test for the U-bend tube bundle which includes advanced anti-vibration bars (AVB) which are very important is described. As a result, it was verified that the bundle has sufficient strength and a relatively high attenuation to seismic loads. These results will be reflected in the detailed design of advanced AVBs. (author)

System Level Analysis of LTE-Advanced

DEFF Research Database (Denmark)

Wang, Yuanye

This PhD thesis focuses on system level analysis of Multi-Component Carrier (CC) management for Long Term Evolution (LTE)-Advanced. Cases where multiple CCs are aggregated to form a larger bandwidth are studied. The analysis is performed for both local area and wide area networks. In local area...... reduction. Compared to the case of reuse-1, they achieve a gain of 50∼500% in cell edge user throughput, with small or no loss in average cell throughput. For the wide area network, effort is devoted to the downlink of LTE-Advanced. Such a system is assumed to be backwards compatible to LTE release 8, i...... scheme is recommended. It reduces the CQI by 94% at low load, and 79∼93% at medium to high load, with reasonable loss in downlink performance. To reduce the ACK/NACK feedback, multiple ACK/NACKs can be bundled, with slightly degraded downlink throughput....

Advanced infrared optically black baffle materials

International Nuclear Information System (INIS)

Seals, R.D.; Egert, C.M.; Allred, D.D.

1990-01-01

Infrared optically black baffle surfaces are an essential component of many advanced optical systems. All internal surfaces in advanced infrared optical sensors that require stray light management to achieve resolution are of primary concern in baffle design. Current industrial materials need improvements to meet advanced optical sensor systems requirements for optical, survivability, and endurability. Baffles are required to survive and operate in potentially severe environments. Robust diffuse-absorptive black surfaces, which are thermally and mechanically stable to threats of x-ray, launch, and in-flight maneuver conditions, with specific densities to allow an acceptable weight load, handleable during assembly, cleanable, and adaptive to affordable manufacturing, are required as optical baffle materials. In this paper an overview of recently developed advanced infrared optical baffle materials, requirements, manufacturing strategies, and the Optics MODIL (Manufacturing Operations Development and Integration Laboratory) Advanced Baffle Program are discussed

E-Personalization and Its Tactical and Beneficial Relationships to E-Tailing

OpenAIRE

Alan D. Smith

2012-01-01

The numerous advancements in electronic-personalization communication have generated both benefits and challenges as online retailers try to regain competitive advantages in the current global recession. Through appropriate multivariate analyses and data-reduction techniques, the basic elements e-personalization, namely online purchasing behaviors, personalized communications, information retrieval services, degree of personal web presence, quality assurance of customer service, and the promo...

Teaching Strategies for Personality Assessment at the Undergraduate Level.

Science.gov (United States)

Roche, Michael J; Jacobson, Nicholas C; Roche, Carley A

2017-01-01

Personality assessment is a crucial component of clinical practice, and the training and proficiency criteria to develop competence are complex and multifaceted. Like many advanced topics, the field of personality assessment would benefit from early exposure in undergraduate classroom settings. This research evaluates how an undergraduate personality course can be enhanced through 2 enrichment activities (self-assessments and a personality project). Students completed several self-assessments of their personality and wrote a comprehensive and integrative personality assessment about themselves. Results demonstrated that these activities increased interest in personality assessment, deepened understanding of course material, and promoted student growth and self-exploration. We discuss the benefits of these enrichment activities for the student, instructor, and field of personality science.

Personality profiles in patients with eating disorders.

Science.gov (United States)

Tomotake, Masahito; Ohmori, Tetsuro

2002-08-01

The present review focused on the personality profiles of patients with eating disorders. Studies using the Structured Clinical Interview for DSM-III-R Personality Disorder showed high rates of diagnostic co-occurrence between eating disorders and personality disorders. The most commonly observed were histrionic, obsessive-compulsive, avoidant, dependent and borderline personality disorders. Studies using the Cloninger's personality theory suggested that high Harm Avoidance might be relevant to the pathology of anorexia nervosa and high Novelty Seeking and Harm Avoidance to bulimia nervosa. Moreover, high Self-Directedness was suggested to be associated with favorable outcome in bulimia nervosa. The assessment of personality in a cross-sectional study, however, might be influenced by the various states of the illness. Therefore, a sophisticated longitudinal study will be required to advance this area of research.

A roadmap towards personalized immunology.

Science.gov (United States)

Delhalle, Sylvie; Bode, Sebastian F N; Balling, Rudi; Ollert, Markus; He, Feng Q

2018-01-01

Big data generation and computational processing will enable medicine to evolve from a "one-size-fits-all" approach to precise patient stratification and treatment. Significant achievements using "Omics" data have been made especially in personalized oncology. However, immune cells relative to tumor cells show a much higher degree of complexity in heterogeneity, dynamics, memory-capability, plasticity and "social" interactions. There is still a long way ahead on translating our capability to identify potentially targetable personalized biomarkers into effective personalized therapy in immune-centralized diseases. Here, we discuss the recent advances and successful applications in "Omics" data utilization and network analysis on patients' samples of clinical trials and studies, as well as the major challenges and strategies towards personalized stratification and treatment for infectious or non-communicable inflammatory diseases such as autoimmune diseases or allergies. We provide a roadmap and highlight experimental, clinical, computational analysis, data management, ethical and regulatory issues to accelerate the implementation of personalized immunology.

30 CFR 77.1604 - Transportation of persons; overcrowding.

Science.gov (United States)

2010-07-01

... UNDERGROUND COAL MINES Loading and Haulage § 77.1604 Transportation of persons; overcrowding. (a) No man-trip... other than small handtools shall not be transported with men in man-trip vehicles unless such vehicles are specifically designed to make such transportation safe. ...

Translating Personality Psychology to Help Personalize Preventive Medicine for Young-Adult Patients

Science.gov (United States)

Israel, Salomon; Moffitt, Terrie E.; Belsky, Daniel W.; Hancox, Robert J.; Poulton, Richie; Roberts, Brent; Thomson, W. Murray; Caspi, Avshalom

2014-01-01

The rising number of newly insured young adults brought on by healthcare reform will soon increase demands on primary-care physicians. Physicians will face more young-adult patients which presents an opportunity for more prevention-oriented care. In the current study, we evaluated whether brief observer reports of young adults’ personality traits could predict which individuals would be at greater risk for poor health as they entered midlife. Following the Dunedin Study cohort of 1,000 individuals, we show that very brief measures of young adults’ personalities predicted their midlife physical health across multiple domains (metabolic abnormalities, cardiorespiratory fitness, pulmonary function, periodontal disease, and systemic inflammation). Individuals scoring low on the traits of Conscientiousness and Openness-to-Experience went on to develop poorer health even after accounting for preexisting differences in education, socioeconomic status, smoking, obesity, self-reported health, medical conditions, and family medical history. Moreover, personality ratings from peer informants who knew participants well, and from a nurse and receptionist who had just met participants for the first time, predicted health decline from young adulthood to midlife despite striking differences in level of acquaintance. Personality effect sizes were on par with other well-established health-risk factors such as socioeconomic status, smoking, and self-reported health. We discuss the potential utility of personality measurement to function as an inexpensive and accessible tool for healthcare professionals to personalize preventive medicine. Adding personality information to existing healthcare electronic infrastructures could also advance personality theory by generating opportunities to examine how personality processes influence doctor-patient communication, health service use, and patient outcomes. PMID:24588093

Activity Recognition for Personal Time Management

Science.gov (United States)

Prekopcsák, Zoltán; Soha, Sugárka; Henk, Tamás; Gáspár-Papanek, Csaba

We describe an accelerometer based activity recognition system for mobile phones with a special focus on personal time management. We compare several data mining algorithms for the automatic recognition task in the case of single user and multiuser scenario, and improve accuracy with heuristics and advanced data mining methods. The results show that daily activities can be recognized with high accuracy and the integration with the RescueTime software can give good insights for personal time management.

Advanced Intelligent System Application to Load Forecasting and Control for Hybrid Electric Bus

Science.gov (United States)

Momoh, James; Chattopadhyay, Deb; Elfayoumy, Mahmoud

1996-01-01

The primary motivation for this research emanates from providing a decision support system to the electric bus operators in the municipal and urban localities which will guide the operators to maintain an optimal compromise among the noise level, pollution level, fuel usage etc. This study is backed up by our previous studies on study of battery characteristics, permanent magnet DC motor studies and electric traction motor size studies completed in the first year. The operator of the Hybrid Electric Car must determine optimal power management schedule to meet a given load demand for different weather and road conditions. The decision support system for the bus operator comprises three sub-tasks viz. forecast of the electrical load for the route to be traversed divided into specified time periods (few minutes); deriving an optimal 'plan' or 'preschedule' based on the load forecast for the entire time-horizon (i.e., for all time periods) ahead of time; and finally employing corrective control action to monitor and modify the optimal plan in real-time. A fully connected artificial neural network (ANN) model is developed for forecasting the kW requirement for hybrid electric bus based on inputs like climatic conditions, passenger load, road inclination, etc. The ANN model is trained using back-propagation algorithm employing improved optimization techniques like projected Lagrangian technique. The pre-scheduler is based on a Goal-Programming (GP) optimization model with noise, pollution and fuel usage as the three objectives. GP has the capability of analyzing the trade-off among the conflicting objectives and arriving at the optimal activity levels, e.g., throttle settings. The corrective control action or the third sub-task is formulated as an optimal control model with inputs from the real-time data base as well as the GP model to minimize the error (or deviation) from the optimal plan. These three activities linked with the ANN forecaster proving the output to the

Artificial intelligence in medicine and cardiac imaging: harnessing big data and advanced computing to provide personalized medical diagnosis and treatment.

Science.gov (United States)

Dilsizian, Steven E; Siegel, Eliot L

2014-01-01

Although advances in information technology in the past decade have come in quantum leaps in nearly every aspect of our lives, they seem to be coming at a slower pace in the field of medicine. However, the implementation of electronic health records (EHR) in hospitals is increasing rapidly, accelerated by the meaningful use initiatives associated with the Center for Medicare & Medicaid Services EHR Incentive Programs. The transition to electronic medical records and availability of patient data has been associated with increases in the volume and complexity of patient information, as well as an increase in medical alerts, with resulting "alert fatigue" and increased expectations for rapid and accurate diagnosis and treatment. Unfortunately, these increased demands on health care providers create greater risk for diagnostic and therapeutic errors. In the near future, artificial intelligence (AI)/machine learning will likely assist physicians with differential diagnosis of disease, treatment options suggestions, and recommendations, and, in the case of medical imaging, with cues in image interpretation. Mining and advanced analysis of "big data" in health care provide the potential not only to perform "in silico" research but also to provide "real time" diagnostic and (potentially) therapeutic recommendations based on empirical data. "On demand" access to high-performance computing and large health care databases will support and sustain our ability to achieve personalized medicine. The IBM Jeopardy! Challenge, which pitted the best all-time human players against the Watson computer, captured the imagination of millions of people across the world and demonstrated the potential to apply AI approaches to a wide variety of subject matter, including medicine. The combination of AI, big data, and massively parallel computing offers the potential to create a revolutionary way of practicing evidence-based, personalized medicine.

Coherent Lidar Turbulence Measurement for Gust Load Alleviation

Science.gov (United States)

Bogue, Rodney K.; Ehernberger, L. J.; Soreide, David; Bagley, Hal

1996-01-01

Atmospheric turbulence adversely affects operation of commercial and military aircraft and is a design constraint. The airplane structure must be designed to survive the loads imposed by turbulence. Reducing these loads allows the airplane structure to be lighter, a substantial advantage for a commercial airplane. Gust alleviation systems based on accelerometers mounted in the airplane can reduce the maximum gust loads by a small fraction. These systems still represent an economic advantage. The ability to reduce the gust load increases tremendously if the turbulent gust can be measured before the airplane encounters it. A lidar system can make measurements of turbulent gusts ahead of the airplane, and the NASA Airborne Coherent Lidar for Advanced In-Flight Measurements (ACLAIM) program is developing such a lidar. The ACLAIM program is intended to develop a prototype lidar system for use in feasibility testing of gust load alleviation systems and other airborne lidar applications, to define applications of lidar with the potential for improving airplane performance, and to determine the feasibility and benefits of these applications. This paper gives an overview of the ACLAIM program, describes the lidar architecture for a gust alleviation system, and describes the prototype ACLAIM lidar system.

Personality measures in the National Social Life, Health, and Aging Project.

Science.gov (United States)

Iveniuk, James; Laumann, Edward O; Waite, Linda J; McClintock, Martha K; Tiedt, Andrew

2014-11-01

Provide recommendations for researchers on the use of the Big Five personality battery in the National Social Life, Health, and Aging Project (NSHAP), and ensure that the battery does proxy the Big Five. Also, describe the levels of Big Five traits across gender and age. We used an Exploratory Structural Equation Model (ESEM) to analyze NHSAP's personality battery, comparing NSHAP with the National Longitudinal Study of Midlife in the United States (MIDUS) and the Health and Retirement Study (HRS). ESEM revealed a 5-factor structure in the NSHAP battery, but with considerable cross-loadings. When these cross-loadings were not included in the model, model fit notably worsened. Reliabilities of Big Five scales were comparable to the HRS and MIDUS, even though NSHAP's battery is shorter. Women were considerably more Agreeable than men, although this gender gap closed among the oldest in the sample (80 years or older). Researchers will be able to make use of NSHAP's personality battery to examine a range of social, biological, and psychological factors at older ages, in light of individuals' general traits. We recommend models which allow for cross-loadings. Published by Oxford University Press on behalf of the Gerontological Society of America 2014.

Novel Applications of Metabolomics in Personalized Medicine: A Mini-Review.

Science.gov (United States)

Li, Bingbing; He, Xuyun; Jia, Wei; Li, Houkai

2017-07-13

Interindividual variability in drug responses and disease susceptibility is common in the clinic. Currently, personalized medicine is highly valued, the idea being to prescribe the right medicine to the right patient. Metabolomics has been increasingly applied in evaluating the therapeutic outcomes of clinical drugs by correlating the baseline metabolic profiles of patients with their responses, i.e., pharmacometabonomics, as well as prediction of disease susceptibility among population in advance, i.e., patient stratification. The accelerated advance in metabolomics technology pinpoints the huge potential of its application in personalized medicine. In current review, we discussed the novel applications of metabolomics with typical examples in evaluating drug therapy and patient stratification, and underlined the potential of metabolomics in personalized medicine in the future.

Personality and Values as Predictors of Medical Specialty Choice

Science.gov (United States)

Taber, Brian J.; Hartung, Paul J.; Borges, Nicole J.

2011-01-01

Research rarely considers the combined influence of personality traits and values in predicting behavioral outcomes. We aimed to advance a germinal line of inquiry that addresses this gap by separately and simultaneously examining personality traits and physician work values to predict medical specialty choice. First-year medical students (125…

The Determination of Load Profiles and Power Consumptions of Home Appliances

Directory of Open Access Journals (Sweden)

Fatih Issi

2018-03-01

Full Text Available In recent years, the increment of distributed electricity generation based on renewable energy sources and improvement of communication technologies have caused the development of next-generation power grids known as smart grids. The structures of smart grids have bidirectional communication capability and enable the connection of energy generated from distributed sources to any point on the grid. They also support consumers in energy efficiency by creating opportunities for management of power consumption. The information on power consumption and load profiles of home appliances is essential to perform load management in the dwelling accurately. In this study, the power consumption data for all the basic home appliances, utilized in a two-person family in Çankırı, Turkey, was obtained with high resolution in one-second intervals. The detailed power consumption analysis and load profile were executed for each home appliance. The obtained data is not only the average power consumption of each appliance but also characterizes different operating modes or their cycles. In addition, the impact of these devices on home energy management studies and their standby power consumptions were also discussed. The acquired data is an important source to determine the load profile of individual home appliances precisely in home energy management studies. Although the results of this study do not completely reflect the energy consumption behavior of the people who live in this region, they can reveal the trends in load demands based on a real sample and customer consumption behavior of a typical two-person family.

Epstein-Barr virus load in transplant patients: Early detection of post-transplant lymphoproliferative disorders.

Science.gov (United States)

Fellner, María Dolores; Durand, Karina A; Solernou, Veronica; Bosaleh, Andrea; Balbarrey, Ziomara; García de Dávila, María T; Rodríguez, Marcelo; Irazu, Lucía; Alonio, Lidia V; Picconi, María A

2016-01-01

High levels of circulating EBV load are used as a marker of post-transplant lymphoproliferative disorders (PTLD). There is no consensus regarding the threshold level indicative of an increase in peripheral EBV DNA. The aim of the study was to clinically validate a developed EBV quantification assay for early PTLD detection. Transversal study: paired peripheral blood mononuclear cells (PBMC), plasma and oropharyngeal lymphoid tissue (OLT) from children undergoing a solid organ transplant with (n=58) and without (n=47) PTLD. Retrospective follow-up: 71 paired PBMC and plasma from recipients with (n=6) and without (n=6) PTLD history. EBV load was determined by real-time PCR. The diagnostic ability to detect all PTLD (categories 1-4), advanced PTLD (categories 2-4) or neoplastic PTLD (categories 3 and 4) was estimated by analyzing the test performance at different cut-off values or with a load variation greater than 0.5log units. The higher diagnostic performance for identifying all, advanced or neoplastic PTLD, was achieved with cut-off values of 1.08; 1.60 and 2.47log EBVgEq/10(5) PBMC or 2.30; 2.60; 4.47loggEq/10(5) OLT cells, respectively. EBV DNA detection in plasma showed high specificity but low (all categories) or high (advanced/neoplastic categories) sensitivity for PTLD identification. Diagnostic performance was greater when: (1) a load variation in PBMC or plasma was identified; (2) combining the measure of EBV load in PBMC and plasma. The best diagnostic ability to identify early PTLD stages was achieved by monitoring EBV load in PBMC and plasma simultaneously; an algorithm was proposed. Copyright © 2016 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.

Load Assembly Design of the FAST Machine

International Nuclear Information System (INIS)

Cucchiaro, A.; Albanese, R.; Ambrosino, G.; Brolatti, G.; Calabro, G.; Cocilovo, V.; Coletti, A.; Coletti, R.; Costa, P.; Frosi, P.; Crescenzi, F.; Crisanti, F.; Granucci, G.; Maddaluno, G.; Pericoli Ridolfini, V.; Pizzuto, A.; Rita, C.; Ramogida, G.

2008-01-01

The FAST [1][2] (Fusion Advanced Studies Torus) load assembly, which includes the Vacuum Vessel (VV) and its internal components, the magnet system and the poloidal field coils, is presented in this paper. FAST operates at a wide range [3][4] of parameters from high performance H-Mode (B T up to 8.5 T; I P up to 8 MA) as well as Advance Tokamak operation (I P =3 MA), and full non inductive current scenario (I P =2 MA). Helium gas at 30K is used for cooling the resistive copper magnets. That allows for a pulse duration up to 170 s (∼ 40 times τres) at 3MA/ 3.5T. To limit the TF magnet ripple ferromagnetic within acceptable values insert have been introduced inside the outboard area of the VV. The VV, segmented by 20 degree modules, is capable to accommodate 40 MW RF power systems. The machine has been designed to house10 MW Negative Neutral Beam injection (NNBI) systems. Tungsten (W) and Liquid Lithium (L-Li) have been chosen as the divertor plates material, and Argon and Neon as the injected impurities to mitigate the thermal loads

Advancement of the state system of accounting for mainframe to personal computer (PC) technology

International Nuclear Information System (INIS)

Proco, G.; Nardi, J.

1999-01-01

The advancement of the U.S. government's state system of accounting from a mainframe computer to a personal computer (PC) had been successfully completed. The accounting system, from 1965 until 1995 a mainframe application, was replaced in September 1995 by an accounting system employing local area network (LAN) capabilities and other state-of-the-art characteristics. The system is called the Nuclear Materials Management and Safeguards System (NMMSS), tracking nuclear material activities and providing accounting reports for a variety of government and private users. The uses of the system include not only the tracking of nuclear materials for international and domestic safeguards purposes but also serving to facilitate the government's resource management purposes as well. The system was converted to PC hardware and fourth generation software to improve upon the mainframe system. The change was motivated by the desire to have a system amenable to frequent modifications, to improve upon services to users and to reduce increasing operating costs. Based on two years of operating the new system, it is clear that these objectives were met. Future changes to the system are inevitable and the national system of accounting for nuclear materials has the technology base to meet the challenges with proven capability. (author)

Neuroimaging in Antisocial Personality Disorder

Directory of Open Access Journals (Sweden)

Abdullah Yildirim

2015-03-01

Full Text Available Neuroimaging has been used in antisocial personality disorder since the invention of computed tomography and new modalities are introduced as technology advances. Magnetic resonance imaging, diffusion tensor imaging, functional magnetic resonance imaging and radionuclide imaging are such techniques that are currently used in neuroimaging. Although neuroimaging is an indispensible tool for psychiatric reseach, its clinical utility is questionable until new modalities become more accessible and regularly used in clinical practice. The aim of this paper is to provide clinicians with an introductory knowledge on neuroimaging in antisocial personality disorder including basic physics principles, current contributions to general understanding of pathophysiology in antisocial personality disorder and possible future applications of neuroimaging. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2015; 7(1: 98-108

Person or system - What leads to surgical advances?

Science.gov (United States)

Hughes, Sean Pf

2017-01-01

To understand the relationship between standardisation and originality in surgery, the contributions of three surgeons in the 20th century are analysed. The individual Arbuthnot Lane, the collectivist Robert Jones and the scientist Alexis Carrel changed the practice of orthopaedic surgery. It is argued that the factors influencing innovation are not binary but multifactorial and that advances in surgery occur when individual freedom is permitted within a system. It is concluded that innovation and standardisation in orthopaedic surgery need not conflict with each other.

Greywater pollution variability and loadings

DEFF Research Database (Denmark)

Eriksson, Eva; Andersen, Henrik Rasmus; Madsen, Toke S.

2009-01-01

Small on-site greywater treatment and reuse plants are susceptible to high short-term variation in flow and pollutant concentrations. As demonstrated in this study of a bathroom greywater plant in Copenhagen, Denmark, the flow ranges from no-flow periods to high-flow periods reaching 34 l min−1...... per day, whereas the paraben loadings were below 1 mg per person per day. These data are highly relevant for comparing decentralised treatment options with existing end-of-pipe treatments, for feeding into risk assessments and for design purposes....

Tumor Slice Culture: A New Avatar in Personalized Oncology

Science.gov (United States)

2017-09-01

AWARD NUMBER: W81XWH-16-1-0149 TITLE: Tumor Slice Culture: A New Avatar in Personalized Oncology PRINCIPAL INVESTIGATOR: Raymond Yeung...CONTRACT NUMBER Tumor Slice Culture: A New Avatar in Personalized Oncology 5b. GRANT NUMBER W81XWH-16-1-0149 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...10 Annual Report 2017: Tumor Slice Culture: A new avatar for personalized oncology 1. INTRODUCTION: The goal of this research is to advance our

Noninvasive Brain Stimulation and Personal Identity: Ethical Considerations.

Science.gov (United States)

Iwry, Jonathan; Yaden, David B; Newberg, Andrew B

2017-01-01

As noninvasive brain stimulation (NIBS) technology advances, these methods may become increasingly capable of influencing complex networks of mental functioning. We suggest that these might include cognitive and affective processes underlying personality and belief systems, which would raise important questions concerning personal identity and autonomy. We give particular attention to the relationship between personal identity and belief, emphasizing the importance of respecting users' personal values. We posit that research participants and patients should be encouraged to take an active approach to considering the personal implications of altering their own cognition, particularly in cases of neurocognitive "enhancement." We suggest that efforts to encourage careful consideration through the informed consent process would contribute usefully to studies and treatments that use NIBS.

Cooperative advanced Driver assistance Systems - Technological measures for data privacy compliance

OpenAIRE

Jäger, Hubert; Schnieder, Lars

2016-01-01

Cooperative advanced driver assistance systems (ADAS) will contribute to road traffic safety: Critical situations will be detected, the driver alerted and control of the vehicle interfered with automatically. However, the introduction of such driver assistance systems presupposes that data privacy issues have already been solved in advance. A necessary condition for the driver to accept and trust new Driver assistance systems is that his/her personal and personally identifiable data will be t...

Using gasoline in an advanced compression ignition engine

Energy Technology Data Exchange (ETDEWEB)

Cracknell, R.F.; Ariztegui, J.; Dubois, T.; Hamje, H.D.C.; Pellegrini, L.; Rickeard, D.J.; Rose, K.D. [CONCAWE, Brussels (Belgium); Heuser, B. [RWTH Aachen Univ. (Germany). Inst. for Combustion Engines; Schnorbus, T.; Kolbeck, A.F. [FEV GmbH, Aachen (Germany)

2013-06-01

Future vehicles will be required to improve their efficiency, reduce both regulated and CO{sub 2} emissions, and maintain acceptable driveability, safety, and noise. To achieve this overall performance, they will be configured with more advanced hardware, sensors, and control technologies that will also enable their operation on a broader range of fuel properties. Fuel flexibility has already been demonstrated in previous studies on a compression ignition bench engine and a demonstration vehicle equipped with an advanced engine management system, closed-loop combustion control, and air-path control strategies. An unresolved question is whether engines of this sort can also operate on market gasoline while achieving diesel-like efficiency and acceptable emissions and noise levels. In this study, a compression ignition bench engine having a higher compression ratio, optimised valve timing, advanced engine management system, and flexible fuel injection could be operated on a European gasoline over full to medium part loads. The combustion was sensitive to EGR rates, however, and optimising all emissions and combustion noise was a considerable challenge at lower loads. (orig.)

Advancing the Assessment of Personality Pathology With the Cognitive-Affective Processing System.

Science.gov (United States)

Huprich, Steven K; Nelson, Sharon M

2015-01-01

The Cognitive-Affective Processing System (CAPS) is a dynamic and expansive model of personality proposed by Mischel and Shoda (1995) that incorporates dispositional and processing frameworks by considering the interaction of the individual and the situation, and the patterns of variation that result. These patterns of cognition, affect, and behavior are generally defined through the use of if … then statements, and provide a rich understanding of the individual across varying levels of assessment. In this article, we describe the CAPS model and articulate ways in which it can be applied to conceptualizing and assessing personality pathology. We suggest that the CAPS model is an ideal framework that integrates a number of current theories of personality pathology, and simultaneously overcomes a number of limits that have been empirically identified in the past.

Pressure ulcer prevention in patients with advanced illness.

Science.gov (United States)

White-Chu, E Foy; Reddy, Madhuri

2013-03-01

Pressure ulcers can be challenging to prevent, particularly in patients with advanced illnesses. This review summarizes the relevant literature since 2011. Through a MEDLINE and CINAHL database search from January 1, 2011 to June 1, 2012, a total of 14 abstracts were found addressing the prevention of pressure ulcers in persons with advanced illness. Search terms included pressure ulcer, prevention, and control. Advanced illness was defined as patients transitioning from curative to supportive and palliative care. Ten original studies and four review articles specifically addressed pressure ulcer prevention. There were four articles that specifically addressed patients with advanced illness. The studies varied in quality. One systematic review, one randomized controlled trial, three prospective trials, two retrospective trials, one cost-effectiveness analysis, one quality improvement project, one comparative descriptive design, and four review articles were found. The interventions for pressure ulcer prevention were risk assessment, repositioning, surface selection, nutritional support and maintenance of skin integrity with or without incontinence. The quality of pressure ulcer prevention studies in persons with advanced illness is poor. Increased number and higher quality studies are needed to further investigate this important topic for these fragile patients.

New perspectives for advanced automobile diesel engines

Science.gov (United States)

Tozzi, L.; Sekar, R.; Kamo, R.; Wood, J. C.

1983-01-01

Computer simulation results are presented for advanced automobile diesel engine performance. Four critical factors for performance enhancement were identified: (1) part load preheating and exhaust gas energy recovery, (2) fast heat release combustion process, (3) reduction in friction, and (4) air handling system efficiency. Four different technology levels were considered in the analysis. Simulation results are compared in terms of brake specific fuel consumption and vehicle fuel economy in km/liter (miles per gallon). Major critical performance sensitivity areas are: (1) combustion process, (2) expander and compressor efficiency, and (3) part load preheating and compound system. When compared to the state of the art direct injection, cooled, automobile diesel engine, the advanced adiabatic compound engine concept showed the unique potential of doubling the fuel economy. Other important performance criteria such as acceleration, emissions, reliability, durability and multifuel capability are comparable to or better than current passenger car diesel engines.

Performance of a cognitive load inventory during simulated handoffs: Evidence for validity.

Science.gov (United States)

Young, John Q; Boscardin, Christy K; van Dijk, Savannah M; Abdullah, Ruqayyah; Irby, David M; Sewell, Justin L; Ten Cate, Olle; O'Sullivan, Patricia S

2016-01-01

Advancing patient safety during handoffs remains a public health priority. The application of cognitive load theory offers promise, but is currently limited by the inability to measure cognitive load types. To develop and collect validity evidence for a revised self-report inventory that measures cognitive load types during a handoff. Based on prior published work, input from experts in cognitive load theory and handoffs, and a think-aloud exercise with residents, a revised Cognitive Load Inventory for Handoffs was developed. The Cognitive Load Inventory for Handoffs has items for intrinsic, extraneous, and germane load. Students who were second- and sixth-year students recruited from a Dutch medical school participated in four simulated handoffs (two simple and two complex cases). At the end of each handoff, study participants completed the Cognitive Load Inventory for Handoffs, Paas' Cognitive Load Scale, and one global rating item for intrinsic load, extraneous load, and germane load, respectively. Factor and correlational analyses were performed to collect evidence for validity. Confirmatory factor analysis yielded a single factor that combined intrinsic and germane loads. The extraneous load items performed poorly and were removed from the model. The score from the combined intrinsic and germane load items associated, as predicted by cognitive load theory, with a commonly used measure of overall cognitive load (Pearson's r = 0.83, p load during handoffs may be measured via a self-report measure. Additional work is required to develop an adequate measure of extraneous load.

Verification tests for CANDU advanced fuel -Development of the advanced CANDU technology-

International Nuclear Information System (INIS)

Chung, Jang Hwan; Suk, Ho Cheon; Jeong, Moon Ki; Park, Joo Hwan; Jeong, Heung Joon; Jeon, Ji Soo; Kim, Bok Deuk

1994-07-01

This project is underway in cooperation with AECL to develop the CANDU advanced fuel bundle (so-called, CANFLEX) which can enhance reactor safety and fuel economy in comparison with the current CANDU fuel and which can be used with natural uranium, slightly enriched uranium and other advanced fuel cycle. As the final schedule, the advanced fuel will be verified by carrying out a large scale demonstration of the bundle irradiation in a commercial CANDU reactor, and consequently will be used in the existing and future CANDU reactors in Korea. The research activities during this year Out-of-pile hydraulic tests for the prototype of CANFLEX bundle was conducted in the CANDU-hot test loop at KAERI. Thermalhydraulic analysis with the assumption of CANFLEX-NU fuel loaded in Wolsong-1 was performed by using thermalhydraulic code, and the thermal margin and T/H compatibility of CANFLEX bundle with existing fuel for CANDU-6 reactor have been evaluated. (Author)

Personal branding through leadership

Directory of Open Access Journals (Sweden)

Milovanović Svetislav

2015-01-01

Full Text Available The main idea of this study is to demonstrate that leadership is increasingly becoming an important and current global phenomenon known as personal branding. Leadership is of utmost importance for each human activity, and even for the entire progress of humanity which has always moved forward thanks to people and, naturally, great endeavors of great people. Leadership is what makes the world go round. Although a personal branding investigated in terms of defining, describing various practices and the growing importance of the use of these techniques, there is still a gap in the scientific literature regarding how technology advancement in the business to take advantage of the positioning of the individual in the global market. Therefore, the primary objective of this paper provide new insights into the personal branding that will be useful for the academic community and provide conclusions for its practical application in entrepreneurship.

Design and Modelling of Thermostatically Controlled Loads as Frequency Controlled Reserve

DEFF Research Database (Denmark)

Xu, Zhao; Østergaard, Jacob; Togeby, Mikael

2007-01-01

Using demand as frequency controlled reserve (DFR) is beneficial to power systems in many aspects. To study the impacts of this technology on power system operation, control logics and simulation models of relevant loads should be carefully developed. Two advanced control logics for using demand...... frequency, is developed. The developed simulation model is able to represent a variety of aggregated thermostatically controlled loads, such as heaters or refrigerators. Uncertainties including customer behaviours and ambient temperature variation are also modelled. Preliminary simulation results...

Personalized telehealth in the future

DEFF Research Database (Denmark)

Dinesen, B.; Nonnecke, B.; Lindeman, David

2016-01-01

of telehealth services and benefits, presents fundamental principles that must be addressed to advance the status quo, and provides a framework for current and future research initiatives within telehealth for personalized care, treatment, and prevention. A broad, multinational research agenda can provide...... research agenda for future telehealth applications within chronic disease management....

Emotion Unchained: Facial Expression Modulates Gaze Cueing under Cognitive Load.

Science.gov (United States)

Pecchinenda, Anna; Petrucci, Manuel

2016-01-01

Direction of eye gaze cues spatial attention, and typically this cueing effect is not modulated by the expression of a face unless top-down processes are explicitly or implicitly involved. To investigate the role of cognitive control on gaze cueing by emotional faces, participants performed a gaze cueing task with happy, angry, or neutral faces under high (i.e., counting backward by 7) or low cognitive load (i.e., counting forward by 2). Results show that high cognitive load enhances gaze cueing effects for angry facial expressions. In addition, cognitive load reduces gaze cueing for neutral faces, whereas happy facial expressions and gaze affected object preferences regardless of load. This evidence clearly indicates a differential role of cognitive control in processing gaze direction and facial expression, suggesting that under typical conditions, when we shift attention based on social cues from another person, cognitive control processes are used to reduce interference from emotional information.

Noninvasive Brain Stimulation and Personal Identity: Ethical Considerations

Directory of Open Access Journals (Sweden)

Jonathan Iwry

2017-06-01

Full Text Available As noninvasive brain stimulation (NIBS technology advances, these methods may become increasingly capable of influencing complex networks of mental functioning. We suggest that these might include cognitive and affective processes underlying personality and belief systems, which would raise important questions concerning personal identity and autonomy. We give particular attention to the relationship between personal identity and belief, emphasizing the importance of respecting users' personal values. We posit that research participants and patients should be encouraged to take an active approach to considering the personal implications of altering their own cognition, particularly in cases of neurocognitive “enhancement.” We suggest that efforts to encourage careful consideration through the informed consent process would contribute usefully to studies and treatments that use NIBS.

Advanced airflow distribution methods for reduction of personal exposure to indoor pollutants

DEFF Research Database (Denmark)

Cao, Guangyu; Kosonen, Risto; Melikov, Arsen

2016-01-01

The main objective of this study is to recognize possible airflow distribution methods to protect the occupants from exposure to various indoor pollutants. The fact of the increasing exposure of occupants to various indoor pollutants shows that there is an urgent need to develop advanced airflow ...... distribution methods to reduce indoor exposure to various indoor pollutants. This article presents some of the latest development of advanced airflow distribution methods to reduce indoor exposure in various types of buildings.......The main objective of this study is to recognize possible airflow distribution methods to protect the occupants from exposure to various indoor pollutants. The fact of the increasing exposure of occupants to various indoor pollutants shows that there is an urgent need to develop advanced airflow...

Personality factors versus expectations and self-reported symptoms among patients awaiting advanced prosthodontic treatment.

Science.gov (United States)

Hakestam, U; Söderfeldt, B; Rydén, O; Glantz, P O

1997-09-01

To assess simple questions for identifying patient personality traits among a normal Swedish population and to assess possible relationships between personality and symptoms, attitudes, dental problems, and received dental care, a questionnaire was sent to 489 subjects awaiting prosthodontic treatment (response rate 84.2%). Three personality traits could be identified: "Fearful-depressed" subjects consumed more tranquillisers, were worried and had many symptoms, whilst "Open-minded" were optimistic about treatment, had high expectations and few symptoms. "Control-minded" did not reveal worries and guarded their autonomy. It was concluded that personality indicators were related to clinically relevant factors: salience of teeth, perceptions of problems, dental attendance pattern, expectations and perceptions of symptoms.

Load responsive multilayer insulation performance testing

Energy Technology Data Exchange (ETDEWEB)

Dye, S.; Kopelove, A. [Quest Thermal Group, 6452 Fig Street Suite A, Arvada, CO 80004 (United States); Mills, G. L. [Ball Aerospace and Technologies Corp, 1600 Commerce Street, Boulder, CO 80301 (United States)

2014-01-29

Cryogenic insulation designed to operate at various pressures from one atmosphere to vacuum, with high thermal performance and light weight, is needed for cryogenically fueled space launch vehicles and aircraft. Multilayer insulation (MLI) performs well in a high vacuum, but the required vacuum shell for use in the atmosphere is heavy. Spray-on foam insulation (SOFI) is often used in these systems because of its light weight, but can have a higher heat flux than desired. We report on the continued development of Load Responsive Multilayer Insulation (LRMLI), an advanced thermal insulation system that uses dynamic beam discrete spacers that provide high thermal performance both in atmosphere and vacuum. LRMLI consists of layers of thermal radiation barriers separated and supported by micromolded polymer spacers. The spacers have low thermal conductance, and self-support a thin, lightweight vacuum shell that provides internal high vacuum in the insulation. The dynamic load responsive spacers compress to support the external load of a vacuum shell in one atmosphere, and decompress under reduced atmospheric pressure for lower heat leak. Structural load testing was performed on the spacers with various configurations. LRMLI was installed on a 400 liter tank and boil off testing with liquid nitrogen performed at various chamber pressures from one atmosphere to high vacuum. Testing was also performed with an MLI blanket on the outside of the LRMLI.

Load responsive multilayer insulation performance testing

International Nuclear Information System (INIS)

Dye, S.; Kopelove, A.; Mills, G. L.

2014-01-01

Cryogenic insulation designed to operate at various pressures from one atmosphere to vacuum, with high thermal performance and light weight, is needed for cryogenically fueled space launch vehicles and aircraft. Multilayer insulation (MLI) performs well in a high vacuum, but the required vacuum shell for use in the atmosphere is heavy. Spray-on foam insulation (SOFI) is often used in these systems because of its light weight, but can have a higher heat flux than desired. We report on the continued development of Load Responsive Multilayer Insulation (LRMLI), an advanced thermal insulation system that uses dynamic beam discrete spacers that provide high thermal performance both in atmosphere and vacuum. LRMLI consists of layers of thermal radiation barriers separated and supported by micromolded polymer spacers. The spacers have low thermal conductance, and self-support a thin, lightweight vacuum shell that provides internal high vacuum in the insulation. The dynamic load responsive spacers compress to support the external load of a vacuum shell in one atmosphere, and decompress under reduced atmospheric pressure for lower heat leak. Structural load testing was performed on the spacers with various configurations. LRMLI was installed on a 400 liter tank and boil off testing with liquid nitrogen performed at various chamber pressures from one atmosphere to high vacuum. Testing was also performed with an MLI blanket on the outside of the LRMLI

Estimated Muscle Loads During Squat Exercise in Microgravity Conditions

Science.gov (United States)

Fregly, Christopher D.; Kim, Brandon T.; Li, Zhao; DeWitt, John K.; Fregly, Benjamin J.

2012-01-01

Loss of muscle mass in microgravity is one of the primary factors limiting long-term space flight. NASA researchers have developed a number of exercise devices to address this problem. The most recent is the Advanced Resistive Exercise Device (ARED), which is currently used by astronauts on the International Space Station (ISS) to emulate typical free-weight exercises in microgravity. ARED exercise on the ISS is intended to reproduce Earth-level muscle loads, but the actual muscle loads produced remain unknown as they cannot currently be measured directly. In this study we estimated muscle loads experienced during squat exercise on ARED in microgravity conditions representative of Mars, the moon, and the ISS. The estimates were generated using a subject-specific musculoskeletal computer model and ARED exercise data collected on Earth. The results provide insight into the capabilities and limitations of the ARED machine.

Note: A novel method for in situ loading of gases via x-ray induced chemistry

Energy Technology Data Exchange (ETDEWEB)

Pravica, Michael; Bai, Ligang; Park, Changyong; Liu, Yu; Galley, Martin; Robinson, John; Bhattacharya, Neelanjan (UNLV); (CIW)

2011-12-14

We have developed and demonstrated a novel method to load oxygen in a sealed diamond anvil cell via the x-ray induced decomposition of potassium chlorate. By irradiating a pressurized sample of an oxidizer (KClO{sub 3}) with either monochromatic or white beam x-rays from the Advanced Photon Source at ambient temperature and variable pressure, we succeeded in creating a localized region of molecular oxygen surrounded by unreacted sample which was confirmed via Raman spectroscopy. We anticipate that this technique will be useful in loading even more challenging, difficult-to-load gases such as hydrogen and also to load multiple gases.

Note: A novel method for in situ loading of gases via x-ray induced chemistry

Science.gov (United States)

Pravica, Michael; Bai, Ligang; Park, Changyong; Liu, Yu; Galley, Martin; Robinson, John; Bhattacharya, Neelanjan

2011-10-01

We have developed and demonstrated a novel method to load oxygen in a sealed diamond anvil cell via the x-ray induced decomposition of potassium chlorate. By irradiating a pressurized sample of an oxidizer (KClO3) with either monochromatic or white beam x-rays from the Advanced Photon Source at ambient temperature and variable pressure, we succeeded in creating a localized region of molecular oxygen surrounded by unreacted sample which was confirmed via Raman spectroscopy. We anticipate that this technique will be useful in loading even more challenging, difficult-to-load gases such as hydrogen and also to load multiple gases.

Results of Laboratory Testing of Advanced Power Strips

Energy Technology Data Exchange (ETDEWEB)

Earle, L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sparn, B. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2012-08-01

Presented at the ACEEE Summer Study on Energy Efficiency in Buildings on August 12-17, 2012, this presentation reports on laboratory tests of 20 currently available advanced power strip products, which reduce wasteful electricity use of miscellaneous electric loads in buildings.

7 CFR 1427.15 - Special procedure where funds are advanced.

Science.gov (United States)

2010-01-01

... financial institution which made the marketing assistance loan or loan deficiency payment advances to the... for each county office by the person, firm, or financial institution which made the marketing... person, firm, or financial institution in the marketing assistance loans or loan deficiency payments. (3...

30 CFR 75.388 - Boreholes in advance of mining.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Boreholes in advance of mining. 75.388 Section... of mining. (a) Boreholes shall be drilled in each advancing working place when the working place... cannot be examined, and before mining continues, a certified person shall, if possible, determine— (1...

Advanced personalized nomogram for myopic laser surgery: First 100 eyes

NARCIS (Netherlands)

Lapid-Gortzak, Ruth; van der Linden, Jan Willem; van der Meulen, Ivanka J. E.; Nieuwendaal, Carla P.

2008-01-01

PURPOSE: To report the results in the first 100 eyes treated for myopia using a new advanced nomogram. SETTING: Private refractive surgery clinic. METHODS: This prospective interventional case series comprised 58 patients (100 eyes) consecutively treated for myopia with laser in situ keratomileusis

Consideration of higher seismic loads at existing plants

Energy Technology Data Exchange (ETDEWEB)

Liebig, J.; Pellissetti, M.

2015-07-01

Because of advancement of methods in probabilistic seismic hazard analysis, plenty of existing plants face higher seismic loads as an obligation from the national authorities. In case of such obligations safety related structures and equipment have to be reevaluated or requalified for the increased seismic loads. The paper provides solutions for different kinds of structures and equipment inside the plant, avoiding cost intensive hardware exchange. Due to higher seismic loads different kinds of structures and equipment inside a plant have to be reevaluated. For civil structures, primary components, mechanical components, distribution lines and electrical and I&C equipment different innovative concepts will be applied to keep structures and equipment qualified for the higher seismic loads. Detailed analysis, including the modeling of non-linear phenomena, or minor structural upgrades are cost competitive, compared to cost intensive hardware exchanges. Several case studies regarding the re-evaluation and requalification of structures and equipment due to higher seismic loads are presented. It is shown how the creation of coupled finite element models and the consistent propagation of acceleration time histories through the soil, building and primary circuit lead to a significant load reduction Electrical and I&C equipment is reinforced by smart upgrades which increase the natural equipment frequencies. Therefore for all devices inside the cabinets the local acceleration will not increase and the seismic qualification will be maintained. The case studies cover both classical deterministic and probabilistic re-evaluations (fragility analysis). Furthermore, the substantial benefits of non-linear limit load evaluation, such as push-over analysis of buildings and limit load analysis of fuel assemblies, are demonstrated. (Author)

Advection and dispersion of bed load tracers

Science.gov (United States)

Lajeunesse, Eric; Devauchelle, Olivier; James, François

2018-05-01

We use the erosion-deposition model introduced by Charru et al. (2004) to numerically simulate the evolution of a plume of bed load tracers entrained by a steady flow. In this model, the propagation of the plume results from the stochastic exchange of particles between the bed and the bed load layer. We find a transition between two asymptotic regimes. The tracers, initially at rest, are gradually set into motion by the flow. During this entrainment regime, the plume is strongly skewed in the direction of propagation and continuously accelerates while spreading nonlinearly. With time, the skewness of the plume eventually reaches a maximum value before decreasing. This marks the transition to an advection-diffusion regime in which the plume becomes increasingly symmetrical, spreads linearly, and advances at constant velocity. We analytically derive the expressions of the position, the variance, and the skewness of the plume and investigate their asymptotic regimes. Our model assumes steady state. In the field, however, bed load transport is intermittent. We show that the asymptotic regimes become insensitive to this intermittency when expressed in terms of the distance traveled by the plume. If this finding applies to the field, it might provide an estimate for the average bed load transport rate.

Provider Tools for Advance Care Planning and Goals of Care Discussions: A Systematic Review.

Science.gov (United States)

Myers, Jeff; Cosby, Roxanne; Gzik, Danusia; Harle, Ingrid; Harrold, Deb; Incardona, Nadia; Walton, Tara

2018-01-01

Advance care planning and goals of care discussions involve the exploration of what is most important to a person, including their values and beliefs in preparation for health-care decision-making. Advance care planning conversations focus on planning for future health care, ensuring that an incapable person's wishes are known and can guide the person's substitute decision maker for future decision-making. Goals of care discussions focus on preparing for current decision-making by ensuring the person's goals guide this process. To provide evidence regarding tools and/or practices available for use by health-care providers to effectively facilitate advance care planning conversations and/or goals of care discussions. A systematic review was conducted focusing on guidelines, randomized trials, comparative studies, and noncomparative studies. Databases searched included MEDLINE, EMBASE, and the proceedings of the International Advance Care Planning Conference and the American Society of Clinical Oncology Palliative Care Symposium. Although several studies report positive findings, there is a lack of consistent patient outcome evidence to support any one clinical tool for use in advance care planning or goals of care discussions. Effective advance care planning conversations at both the population and the individual level require provider education and communication skill development, standardized and accessible documentation, quality improvement initiatives, and system-wide coordination to impact the population level. There is a need for research focused on goals of care discussions, to clarify the purpose and expected outcomes of these discussions, and to clearly differentiate goals of care from advance care planning.

Personalized health care: from theory to practice.

Science.gov (United States)

Snyderman, Ralph

2012-08-01

The practice of medicine stands at the threshold of a transformation from its current focus on the treatment of disease events to an emphasis on enhancing health, preventing disease and personalizing care to meet each individual's specific health needs. Personalized health care is a new and strategic approach that is driven by personalized health planning empowered by personalized medicine tools, which are facilitated by advances in science and technology. These tools improve the capability to predict health risks, to determine and quantify the dynamics of disease development, and to target therapeutic approaches to the needs of the individual. Personalized health care can be implemented today using currently available technologies and know-how and thereby provide a market for the rational introduction of new personalized medicine tools. The need for early adoption of personalized health care stems from the necessity to reduce the egregious and wasteful burden of preventable chronic diseases, which is not effectively addressed by our current approach to care. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Technology advancement of the electrochemical CO2 concentrating process

Science.gov (United States)

Schubert, F. H.; Heppner, D. B.; Hallick, T. M.; Woods, R. R.

1979-01-01

Two multicell, liquid-cooled, advanced electrochemical depolarized carbon dioxide concentrator modules were fabricated. The cells utilized advanced, lightweight, plated anode current collectors, internal liquid cooling and lightweight cell frames. Both were designed to meet the carbon dioxide removal requirements of one-person, i.e., 1.0 kg/d (2.2 lb/d).

Religion, culture, and discrimination against persons with disabilities in Nigeria

Directory of Open Access Journals (Sweden)

Edwin Etieyibo

2016-10-01

Conclusion: Given the unfairness and wrongness of these practices they ought to be deplored. Moreover, the Nigerian government needs to push through legislation that targets cultural and religious practices which are discriminatory against persons with disabilities as well as undertake effective and appropriate measures aimed at protecting and advancing the interests of persons with disabilities.

On Advanced Control Methods toward Power Capture and Load Mitigation in Wind Turbines

Institute of Scientific and Technical Information of China (English)

Yuan Yuan; Jiong Tang

2017-01-01

This article provides a survey of recently emerged methods for wind turbine control.Multivariate control approaches to the optimization of power capture and the reduction of loads in components under time-varying turbulent wind fields have been under extensive investigation in recent years.We divide the related research activities into three categories:modeling and dynamics of wind turbines,active control of wind turbines,and passive control of wind turbines.Regarding turbine dynamics,we discuss the physical fundamentals and present the aeroelastic analysis tools.Regarding active control,we review pitch control,torque control,and yaw control strategies encompassing mathematical formulations as well as their applications toward different objectives.Our survey mostly focuses on blade pitch control,which is considered one of the key elements in facilitating load reduction while maintaining power capture performance.Regarding passive control,we review techniques such as tuned mass dampers,smart rotors,and microtabs.Possible future directions are suggested.

A method for calculation of finite fatigue life under multiaxial loading in high-cycle domain

Directory of Open Access Journals (Sweden)

M. Malnati

2014-04-01

Full Text Available A method for fatigue life assessment in high-cycle domain under multiaxial loading is presented in this paper. This approach allows fatigue assessment under any kind of load history, without limitations. The methodology lies on the construction - at a macroscopic level - of an “indicator” in the form of a set of cycles, representing plasticity that can arise at mesoscopic level throughout fatigue process. During the advancement of the loading history new cycles are created and a continuous evaluation of the damage is made.

Advances in the simulation of personal protective equipment for the mitigation of exposure to radioactive particulates

International Nuclear Information System (INIS)

Roeterink, M.J.; Kelly, D.G.; Dickson, E.F.G; Corcoran, E.C.

2014-01-01

Airborne radioactive particulates represent a significant potential hazard to first responders in nuclear related incidents. Personal protective equipment (PPE), in particular radio-opaque fabrics, can be used to reduce wearer exposure to the emitted radiation, but do not offer complete protection. The objective of this project is to create a realistic dosimetric model of the human arm, protected by a sleeve, which can eventually be developed into a tool to assess the full-body dose imparted to the wearer in the event of radiological particulate exposure. A two-fold approach will be employed whereby: (1) a particulate transport model will be used to determine the regional radioactive particulate concentrations; and (2) these concentration data will then be incorporated into a dosimetric model that will use the Monte Carlo N-Particle (MCNP) transport code to determine the dose imparted to the tissue. Benchmarking experiments will be carried out to validate the results generated by the computer models. Such experimentation will be conducted for both the particulate transport and dosimetric models. Model advancement aims to consider whole body dose and will be invaluable in the development of future radiation exposure policies and procedures. (author)

Traveling wave accelerating structures with a large phase advance

International Nuclear Information System (INIS)

Paramonov, V.V.

2012-01-01

The cells RF parameters for the well known Disk Loaded Waveguide (DLW) are considered in higher pass bands of TM01 wave, providing operating phase advance between 180 o - 1230 o per cell. With an appropriate shape optimization and some additional elements proposed traveling wave structures with such large phase advance overlap the classical first band DLW in RF efficiency. Examples of proposed structures together with RF and dispersion properties are presented.

Artificial heart pumps: bridging the gap between science, technology and personalized medicine by relational medicine.

Science.gov (United States)

Raia, Federica; Deng, Mario C

2017-01-01

In the US population of 300 million, 3 million have heart failure with reduced ejection fraction and 300,000 have advanced heart failure. Long-term mechanical circulatory support will, within the next decade, be recommended to 30,000 patients annually in the USA, 3000 undergo heart transplantation annually. What do these advances mean for persons suffering from advanced heart failure and their loved ones/caregivers? In this perspective article, we discuss - by exemplifying a case report of a 27-year-old man receiving a Total Artificial Heart - a practice concept of modern medicine that fully incorporates the patient's personhood perspective which we have termed Relational Medicine™. From this case study, it becomes apparent that the successful practice of modern cardiovascular medicine requires the person-person encounter as a core practice element.

The advanced microgrid. Integration and interoperability

Energy Technology Data Exchange (ETDEWEB)

Bower, Ward Isaac [Ward Bower Innovations, LLC, Albuquerque, NM (United Staes); Ton, Dan T. [U.S. Dept. of Energy, Washington, DC (United States); Guttromson, Ross [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Glover, Steven F [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Stamp, Jason Edwin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bhatnagar, Dhruv [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Reilly, Jim [Reily Associates, Pittston, PA (United States)

2014-02-01

This white paper focuses on "advanced microgrids," but sections do, out of necessity, reference today's commercially available systems and installations in order to clearly distinguish the differences and advances. Advanced microgrids have been identified as being a necessary part of the modern electrical grid through a two DOE microgrid workshops, the National Institute of Standards and Technology, Smart Grid Interoperability Panel and other related sources. With their grid-interconnectivity advantages, advanced microgrids will improve system energy efficiency and reliability and provide enabling technologies for grid-independence to end-user sites. One popular definition that has been evolved and is used in multiple references is that a microgrid is a group of interconnected loads and distributed-energy resources within clearly defined electrical boundaries that acts as a single controllable entity with respect to the grid. A microgrid can connect and disconnect from the grid to enable it to operate in both grid-connected or island-mode. Further, an advanced microgrid can then be loosely defined as a dynamic microgrid.

Advanced composites for windmills

Science.gov (United States)

Bourquardez, G.

A development status assessment is conducted for advanced composite construction techniques for windmill blade structures which, as in the case of composite helicopter rotors, promise greater reliability, longer service life, superior performance, and lower costs. Composites in wind turbine applications must bear aerodynamic, inertial and gravitational loads in complex interaction cycles. Attention is given to large Darrieus-type vertical axis windmills, to which composite construction methods may offer highly effective pitch-control mechanisms, especially in the 'umbrella' configuration.

Computational methods for structural load and resistance modeling

Science.gov (United States)

Thacker, B. H.; Millwater, H. R.; Harren, S. V.

1991-01-01

An automated capability for computing structural reliability considering uncertainties in both load and resistance variables is presented. The computations are carried out using an automated Advanced Mean Value iteration algorithm (AMV +) with performance functions involving load and resistance variables obtained by both explicit and implicit methods. A complete description of the procedures used is given as well as several illustrative examples, verified by Monte Carlo Analysis. In particular, the computational methods described in the paper are shown to be quite accurate and efficient for a material nonlinear structure considering material damage as a function of several primitive random variables. The results show clearly the effectiveness of the algorithms for computing the reliability of large-scale structural systems with a maximum number of resolutions.

Design and performance of a 2-megawatt high voltage dc test load

International Nuclear Information System (INIS)

Horan, D.; Kustom, R.; Ferguson, M.

1994-01-01

A high-power water-cooled resistive load which simulates the electrical load characteristics of a high-power klystron, capable of a 2 MW dissipation at 95 kV DC, is designed and installed. The load utilizes wirewound resistor elements suspended inside G-11 insulated tubing contained within a single-wall 316 stainless steel pressure vessel with flanged elliptical heads. The vessel supplies a continuous flow of deionized water. Baffles fabricated from G-10 sheets support the tubing and promote water turbulence to maximize heat removal. A companion oil tank houses resistive filament and mod-anode power supply test loads, plus an electrical interlock system which provides protection from inadequate water flow, excessive oil temperature, and arcing in either the pressure vessel or oil tank. A secondary safety system consists of both hydrostatic and steam pressure relief valves on the pressure vessel. Power supply tests indicate the load simulates the electrical load characteristics of a high-power klystron to a degree sufficient to accurately performance-test the rf high voltage power supplies used at the Advanced Photon Source

The relationship between locus of control and career advancement

OpenAIRE

2014-01-01

M.Com. (Industrial Psychology) The objective which career of this study advancement is was to investigate the extent to contingent on the personality construct locus of control. In order to achieve this, empirical research was conducted in a South African organisation. A survey questionnaire measuring career advancement and locus of control was completed by 152 subjects. The hypothesis which was formulated was that people with higher rates of career advancement would be more internal and t...

Towards Personal Exposures: How Technology Is Changing Air Pollution and Health Research.

Science.gov (United States)

Larkin, A; Hystad, P

2017-12-01

We present a review of emerging technologies and how these can transform personal air pollution exposure assessment and subsequent health research. Estimating personal air pollution exposures is currently split broadly into methods for modeling exposures for large populations versus measuring exposures for small populations. Air pollution sensors, smartphones, and air pollution models capitalizing on big/new data sources offer tremendous opportunity for unifying these approaches and improving long-term personal exposure prediction at scales needed for population-based research. A multi-disciplinary approach is needed to combine these technologies to not only estimate personal exposures for epidemiological research but also determine drivers of these exposures and new prevention opportunities. While available technologies can revolutionize air pollution exposure research, ethical, privacy, logistical, and data science challenges must be met before widespread implementations occur. Available technologies and related advances in data science can improve long-term personal air pollution exposure estimates at scales needed for population-based research. This will advance our ability to evaluate the impacts of air pollution on human health and develop effective prevention strategies.

An Integrative Dimensional Classification of Personality Disorder

Science.gov (United States)

Widiger, Thomas A.; Livesley, W. John; Clark, Lee Anna

2009-01-01

Psychological assessment research concerns how to describe psychological dysfunction in ways that are both valid and useful. Recent advances in assessment research hold the promise of facilitating significant improvements in description and diagnosis. One such contribution is in the classification of personality disorder symptomatology. The…

Where have we gone wrong? Perceptual load does not affect selective attention.

Science.gov (United States)

Benoni, Hanna; Tsal, Yehoshua

2010-06-18

The theory of perceptual load (Lavie & Tsal, 1994) proposes that with low load in relevant processing left over resources spill over to process irrelevant distractors. Interference could only be prevented under High-Load Conditions where relevant processing exhausts attentional resources. The theory is based primarily on the finding that distractor interference obtained in low load displays, when the target appears alone, is eliminated in high load displays when it is embedded among neutral letters. However, a possible alternative interpretation of this effect is that the distractor is similarly processed in both displays, yet its interference in the large displays is diluted by the presence of the neutral letters. We separated the possible effects of load and dilution by adding dilution displays that were high in dilution and low in perceptual load. In the first experiment these displays contained as many letters as the high load displays, but their neutral letters were clearly distinguished from the target, thereby allowing for a low load processing mode. In the second experiment we presented identical multicolor displays in the Dilution and High-Load Conditions. However, in the former the target color was known in advance (thereby preserving a low load processing mode) whereas in the latter it was not. In both experiments distractor interference was completely eliminated under the Dilution Condition. Thus, it is dilution not perceptual load affecting distractor processing. 2010 Elsevier Ltd. All rights reserved.

Leaders' Personal Wisdom and Leader-Member Exchange Quality : The Role of Individualized Consideration

NARCIS (Netherlands)

Zacher, Hannes; Pearce, Liane K.; Rooney, David; McKenna, Bernard

Business scholars have recently proposed that the virtue of personal wisdom may predict leadership behaviors and the quality of leader-follower relationships. This study investigated relationships among leaders' personal wisdom-defined as the integration of advanced cognitive, reflective, and

Load-cell based characterization system for a "Violin-Mode" shadow-sensor in advanced LIGO suspensions

Science.gov (United States)

Lockerbie, N. A.; Tokmakov, K. V.

2016-07-01

The background to this work was a prototype shadow sensor, which was designed for retro-fitting to an advanced LIGO (Laser Interferometer Gravitational wave Observatory) test-mass/mirror suspension, in which 40 kg test-mass/mirrors are each suspended by four approximately 600 mm long by 0.4 mm diameter fused-silica suspension fibres. The shadow sensor comprised a LED source of Near InfraRed (NIR) radiation and a rectangular silicon photodiode detector, which, together, were to bracket the fibre under test. The aim was to detect transverse Violin-Mode resonances in the suspension fibres. Part of the testing procedure involved tensioning a silica fibre sample and translating it transversely through the illuminating NIR beam, so as to measure the DC responsivity of the detection system to fibre displacement. However, an equally important part of the procedure, reported here, was to keep the fibre under test stationary within the beam, whilst trying to detect low-level AC Violin-Mode resonances excited on the fibre, in order to confirm the primary function of the sensor. Therefore, a tensioning system, incorporating a load-cell readout, was built into the test fibre's holder. The fibre then was excited by a signal generator, audio power amplifier, and distant loudspeaker, and clear resonances were detected. A theory for the expected fundamental resonant frequency as a function of fibre tension was developed and is reported here, and this theory was found to match closely with the detected resonant frequencies as they varied with tension. Consequently, the resonances seen were identified as being proper Violin-Mode fundamental resonances of the fibre, and the operation of the Violin-Mode detection system was validated.

DeRisk - Accurate prediction of ULS wave loads. Outlook and first results

DEFF Research Database (Denmark)

Bredmose, Henrik; Dixen, Martin; Ghadirian, Amin

2016-01-01

Loads from extreme waves can be dimensioning for the substructures of offshore wind turbines. The DeRisk project (2015-2019) aims at an improved load evaluation procedure for extreme waves through application of advanced wave models, laboratory tests of load effects, development of hydrodynamic...... load models, aero-elastic response calculations and statistical analysis. This first paper from the project outlines the content and philosophy behind DeRisk. Next, the first results from laboratory tests with irregular waves are presented, including results for 2D and 3D focused wave groups....... The results of focused wave group tests and a 6-hour (full scale duration) test are reproduced numerically by re-application of the wave paddle signal in a fully nonlinear potential flow wave model. A good match for the free surface elevation and associated exceedance probability curve is obtained. Finally...

Simulation of pore pressure accumulation under cyclic loading using Finite Volume Method

DEFF Research Database (Denmark)

Tang, Tian; Hededal, Ole

2014-01-01

This paper presents a finite volume implementation of a porous, nonlinear soil model capable of simulating pore pressure accumulation under cyclic loading. The mathematical formulations are based on modified Biot’s coupled theory by substituting the original elastic constitutive model...... with an advanced elastoplastic model suitable for describing monotonic as well as cyclic loading conditions. The finite volume method is applied to discretize these formulations. The resulting set of coupled nonlinear algebraic equations are then solved by a ’segregated’ solution procedure. An efficient return...

Molecular analysis of microbial diversity in advanced caries.

Science.gov (United States)

Chhour, Kim-Ly; Nadkarni, Mangala A; Byun, Roy; Martin, F Elizabeth; Jacques, Nicholas A; Hunter, Neil

2005-02-01

Real-time PCR analysis of the total bacterial load in advanced carious lesions has shown that the total load exceeds the number of cultivable bacteria. This suggests that an unresolved complexity exists in bacteria associated with advanced caries. In this report, the profile of the microflora of carious dentine was explored by using DNA extracted from 10 lesions selected on the basis of comparable total microbial load and on the relative abundance of Prevotella spp. Using universal primers for the 16S rRNA gene, PCR amplicons were cloned, and approximately 100 transformants were processed for each lesion. Phylogenetic analysis of 942 edited sequences demonstrated the presence of 75 species or phylotypes in the 10 carious lesions. Up to 31 taxa were represented in each sample. A diverse array of lactobacilli were found to comprise 50% of the species, with prevotellae also abundant, comprising 15% of the species. Other taxa present in a number of lesions or occurring with high abundance included Selenomonas spp., Dialister spp., Fusobacterium nucleatum, Eubacterium spp., members of the Lachnospiraceae family, Olsenella spp., Bifidobacterium spp., Propionibacterium sp., and Pseudoramibacter alactolyticus. The mechanisms by which such diverse patterns of bacteria extend carious lesions, including the aspect of infection of the vital dental pulp, remain unclear.

Advanced airflow distribution methods for reducing exposure of indoor pollution

DEFF Research Database (Denmark)

Cao, Guangyu; Nielsen, Peter Vilhelm; Melikov, Arsen

2017-01-01

The adverse effect of various indoor pollutants on occupants’ health have been recognized. In public spaces flu viruses may spread from person to person by airflow generated by various traditional ventilation methods, like natural ventilation and mixing ventilation (MV Personalized ventilation (PV......) supplies clean air close to the occupant and directly into the breathing zone. Studies show that it improves the inhaled air quality and reduces the risk of airborne cross-infection in comparison with total volume (TV) ventilation. However, it is still challenging for PV and other advanced air distribution...... methods to reduce the exposure to gaseous and particulate pollutants under disturbed conditions and to ensure thermal comfort at the same time. The objective of this study is to analyse the performance of different advanced airflow distribution methods for protection of occupants from exposure to indoor...

Advanced airflow distribution methods for reducing exposure of indoor pollution

DEFF Research Database (Denmark)

Cao, Guangyu; Nielsen, Peter Vilhelm; Melikov, Arsen Krikor

methods to reduce the exposure to gaseous and particulate pollutants under disturbed conditions and to ensure thermal comfort at the same time. The objective of this study is to analyse the performance of different advanced airflow distribution methods for protection of occupants from exposure to indoor......The adverse effect of various indoor pollutants on occupants’ health have been recognized. In public spaces flu viruses may spread from person to person by airflow generated by various traditional ventilation methods, like natural ventilation and mixing ventilation (MV Personalized ventilation (PV......) supplies clean air close to the occupant and directly into the breathing zone. Studies show that it improves the inhaled air quality and reduces the risk of airborne cross-infection in comparison with total volume (TV) ventilation. However, it is still challenging for PV and other advanced air distribution...

Load research manual. Volume 1. Load research procedures

Energy Technology Data Exchange (ETDEWEB)

Brandenburg, L.; Clarkson, G.; Grund, Jr., C.; Leo, J.; Asbury, J.; Brandon-Brown, F.; Derderian, H.; Mueller, R.; Swaroop, R.

1980-11-01

This three-volume manual presents technical guidelines for electric utility load research. Special attention is given to issues raised by the load data reporting requirements of the Public Utility Regulatory Policies Act of 1978 and to problems faced by smaller utilities that are initiating load research programs. In Volumes 1 and 2, procedures are suggested for determining data requirements for load research, establishing the size and customer composition of a load survey sample, selecting and using equipment to record customer electricity usage, processing data tapes from the recording equipment, and analyzing the data. Statistical techniques used in customer sampling are discussed in detail. The costs of load research also are estimated, and ongoing load research programs at three utilities are described. The manual includes guides to load research literature and glossaries of load research and statistical terms.

Development and Implementation of an Advanced Power Management Algorithm for Electronic Load Sensing on a Telehandler

DEFF Research Database (Denmark)

Hansen, Rico Hjerm; Andersen, Torben Ole; Pedersen, Henrik C.

2010-01-01

The relevance of electronic control of mobile hydraulic systems is increasing as hydraulic components are implemented with more electrical sensors and actuators. This paper presents how the traditional Hydro-mechanical Load Sensing (HLS) control of a specific mobile hydraulic application......, a telehandler, can be replaced with electronic control, i.e. Electronic Load Sensing (ELS). The motivation is the potential of improved dynamic performance and power utilization, along with reducing the mechanical complexity by moving traditional hydro-mechanical implemented features such as pressure control...

A strategy for load balancing in distributed storage systems

CERN Multimedia

CERN. Geneva

2012-01-01

Distributed storage systems are critical to the operation of the WLCG. These systems are not limited to fulfilling the long term storage requirements. They also serve data for computational analysis and other computational jobs. Distributed storage systems provide the ability to aggregate the storage and IO capacity of disks and tapes, but at the end of the day IO rate is still bound by the capabilities of the hardware, in particular the hard drives. Throughput of hard drives has increased dramatically over the decades, however for computational analysis IOPS is typically the limiting factor. To maximize return of investment, balancing IO load over available hardware is crucial. The task is made complicated by the common use of heterogeneous hardware and software environments that results from combining new and old hardware into a single storage system. This paper describes recent advances made in load balancing in the dCache distributed storage system. We describe a set of common requirements for load balan...

Load power device, system and method of load control and management employing load identification

Science.gov (United States)

Yang, Yi; Luebke, Charles John; Schoepf, Thomas J.

2018-01-09

A load power device includes a power input, at least one power output for at least one load, a plurality of sensors structured to sense voltage and current at the at least one power output, and a processor. The processor provides: (a) load identification based upon the sensed voltage and current, and (b) load control and management based upon the load identification.

The behavioural genetics of personality development in adulthood-classic, contemporary, and future trends

NARCIS (Netherlands)

Bleidorn, Wiebke; Kandler, Christian; Caspi, Avshalom

2014-01-01

Behavioural genetic research has led to important advances in the field of personality psychology. When carried out on longitudinal data, behavioural genetic studies also offer promising ways to examine the genetic and environmental origins of personality stability and change. Here, we review the

Status and challenges of residential and industrial non-intrusive load monitoring

DEFF Research Database (Denmark)

Adabi, Ali; Mantey, Patrick; Holmegaard, Emil

2015-01-01

in recent years due to improvement in algorithms and methodologies. Currently, the important challenges facing residential NILM are inaccessibility of electricity meter high sampling data, and lack of reliable high resolution datasets. For industrial NILM the identification is more challenging due......Non-Intrusive Load Monitoring (NILM) is the process of identification of loads from an aggregate power interface using disaggregation algorithms. This paper identifies the current status, methodologies and challenges of NILM in residential and industrial settings. NILM has advanced substantially...... to increased number of loads and the variability of equipment type, temporal patterns and industrial secrecy. From our examination of data and its use in NILM, we observe that the number of devices that can be recognized and the training period required to achiever recognition is not only a function...

Loads for use in the design of ships and offshore structures

DEFF Research Database (Denmark)

Hirdaris, S.E.; Bai, W.; Dessi, Daniele

2014-01-01

The evaluation of structural responses is key element in the design of ships and offshore structures. Fundamental to this is the determination of the design loads to support the Rule requirements and for application in direct calculations. To date, the current design philosophy for the prediction...... of motions and wave-induced loads has been driven by empirical or first-principles calculation procedures based on well-proven applications such as ship motion prediction programs. In recent years, the software, engineering and computer technology available to predict the design loads imposed on ships...... and offshore structures has improved dramatically. Notwithstanding, with the stepwise increase in the size and structural complexity of ships and floating offshore installations and the advances in the framework of Rules and Standards it has become necessary to utilise the latest technologies to assess...

“Personal mission statement”: An analysis of medical students’ and general practitioners’ reflections on personal beliefs, values and goals in life

Directory of Open Access Journals (Sweden)

Chew Boon How

2014-08-01

Full Text Available Personal mission in life can determine motivation, happiness, future career advancement and fulfilment in life of the medical students (MSs along with improvement in professional/ clinical performance of the family physicians.1–5 These personal internal qualities are largely represented by the professional functional knowledge base, which can be influenced by personal awareness (pre-propositional impressions that trigger experiential learning and moral principles.6 Physicians often deal with patients with complex medical and social problems.7 Therefore, a physician’s self-understanding, insight into the nature, limitations of the knowledge and capacity of applying it are crucial in professional practice.8

Influence of the control system on wind turbine loads during power production in extreme turbulence: Structural reliability

DEFF Research Database (Denmark)

Abdallah, Imad; Natarajan, Anand; Sørensen, John Dalsgaard

2016-01-01

structural reliability are assessed when the extreme turbulence model is uncertain. The structural reliability is assessed for the wind turbine when three configurations of an industrial grade load alleviation control system of increasing complexity and performance are used. The load alleviation features......The wind energy industry is continuously researching better computational models of wind inflow and turbulence to predict extreme loading (the nature of randomness) and their corresponding probability of occurrence. Sophisticated load alleviation control systems are increasingly being designed...... and deployed to specifically reduce the adverse effects of extreme load events resulting in lighter structures. The main objective herein is to show that despite large uncertainty in the extreme turbulence models, advanced load alleviation control systems yield both a reduction in magnitude and scatter...

Personality Changes after Deep Brain Stimulation in Parkinson’s Disease

Directory of Open Access Journals (Sweden)

Uyen Pham

2015-01-01

Full Text Available Objectives. Deep brain stimulation of the subthalamic nucleus (STN-DBS is a recognized therapy that improves motor symptoms in advanced Parkinson’s disease (PD. However, little is known about its impact on personality. To address this topic, we have assessed personality traits before and after STN-DBS in PD patients. Methods. Forty patients with advanced PD were assessed with the Temperament and Character Inventory (TCI: the Urgency, Premeditation, Perseverance, Sensation Seeking impulsive behaviour scale (UPPS, and the Neuroticism and Lie subscales of the Eysenck Personality Questionnaire (EPQ-N, EPQ-L before surgery and after three months of STN-DBS. Collateral information obtained from the UPPS was also reported. Results. Despite improvement in motor function and reduction in dopaminergic dosage patients reported lower score on the TCI Persistence and Self-Transcendence scales, after three months of STN-DBS, compared to baseline (P=0.006; P=0.024. Relatives reported significantly increased scores on the UPPS Lack of Premeditation scale at follow-up (P=0.027. Conclusion. STN-DBS in PD patients is associated with personality changes in the direction of increased impulsivity.

A national survey of genetic counselors' personal values.

Science.gov (United States)

Pirzadeh, Sara M; McCarthy Veach, Patricia; Bartels, Dianne M; Kao, Juihsien; Leroy, Bonnie S

2007-12-01

Personal values are motivational sources for an individual's actions [Hitlin and Piliavin (Annual Review of Sociology 30:359-393, 2004)]. Genetic counselors' values may influence their behaviors in clinical practice, but a profile of their personal values has not been identified empirically. In this study, 292 genetic counselors completed the Schwartz Universal Values Questionnaire (SUVQ; Schwartz, S. H. (1992). Universals in the content and structure of values: Theoretical advances and empirical tests in 20 countries. In M. Zanna (Ed.), Advances in experimental social psychology (pp. 1-65). Boston, MA: Academic.), a widely used measure of value types, and provided information about their demographic characteristics. Results indicate that respondents highly valued benevolence, self-direction, achievement, and universalism indicating a strong pattern of concern for the welfare of others. They placed considerably less value on stimulation, tradition, and power, which reflect personal interests. Respondents who reported practicing a religion scored significantly lower on stimulation and hedonism and higher on tradition and spirituality than those not practicing; married respondents and parents scored significantly lower on stimulation and achievement; and males scored higher on power than females. The value types are described, and training and research recommendations are provided.

Personal strategic planning mobile application: preliminary study ...

African Journals Online (AJOL)

With the recent advances in the capabilities of smartphones and their growing penetration rate among the individuals, it is possible to take advantage of these devices to design a mobile application to promote personal strategic planning. The paper reviews relevant literature and designs an instrument to investigate the ...

77 FR 19937 - Inflatable Personal Flotation Devices

Science.gov (United States)

2012-04-03

... Advancement Act OMB Office of Management and Budget PFD Personal flotation device STP Standards Technical... using existing inflatable PFDs, and would enable marketing of existing inflatable PFDs to youth. The... approved, and thus does not affect the availability, use, or marketing of existing PFDs to or by the youth...

Active tuberculosis among homeless persons, Toronto, Ontario, Canada, 1998-2007.

Science.gov (United States)

Khan, Kamran; Rea, Elizabeth; McDermaid, Cameron; Stuart, Rebecca; Chambers, Catharine; Wang, Jun; Chan, Angie; Gardam, Michael; Jamieson, Frances; Yang, Jae; Hwang, Stephen W

2011-03-01

While tuberculosis (TB) in Canadian cities is increasingly affecting foreign-born persons, homeless persons remain at high risk. To assess trends in TB, we studied all homeless persons in Toronto who had a diagnosis of active TB during 1998-2007. We compared Canada-born and foreign-born homeless persons and assessed changes over time. We identified 91 homeless persons with active TB; they typically had highly contagious, advanced disease, and 19% died within 12 months of diagnosis. The proportion of homeless persons who were foreign-born increased from 24% in 1998-2002 to 39% in 2003-2007. Among foreign-born homeless persons with TB, 56% of infections were caused by strains not known to circulate among homeless persons in Toronto. Only 2% of infections were resistant to first-line TB medications. The rise in foreign-born homeless persons with TB strains likely acquired overseas suggests that the risk for drug-resistant strains entering the homeless shelter system may be escalating.

Investigation of the in-vitro loading on an artificial spinal disk prosthesis

Energy Technology Data Exchange (ETDEWEB)

Kyriacou, P A; Pancholi, M P [School of Engineering and Mathematical Sciences, City University London (United Kingdom); Yeh, J, E-mail: P.Kyriacou@city.ac.u [Department of Neurosurgery, Royal London Hospital, Barts and the London NHS Trust, London (United Kingdom)

2009-07-01

Spinal diseases imposes considerable burden to both patients and society. In recent years, much surgical efforts have been made in advancing the treatment of neck and back pain. Of particular prominence is the increasing clinical acceptance and use of intervertebral artificial disk prosthesis for the treatment of discogenic back pain. Despite this increased use of such disks, their in-vivo monitoring remains rudimentary. In an effort to develop an intelligent artificial spinal disk where the in-vivo loading of the spine can by studied for the first time an experimental set up has been created in order to initially study the in-vitro loading on an artificial disc prosthesis. Eight strain gauges and two piezoresistive sensors were used and placed suitably in the artificial disk prosthesis. The results from the in-vitro loading showed linear relationship between loading and the outputs from the sensors with good repeatability and less hysteresis.

Investigation of the in-vitro loading on an artificial spinal disk prosthesis

International Nuclear Information System (INIS)

Kyriacou, P A; Pancholi, M P; Yeh, J

2009-01-01

Spinal diseases imposes considerable burden to both patients and society. In recent years, much surgical efforts have been made in advancing the treatment of neck and back pain. Of particular prominence is the increasing clinical acceptance and use of intervertebral artificial disk prosthesis for the treatment of discogenic back pain. Despite this increased use of such disks, their in-vivo monitoring remains rudimentary. In an effort to develop an intelligent artificial spinal disk where the in-vivo loading of the spine can by studied for the first time an experimental set up has been created in order to initially study the in-vitro loading on an artificial disc prosthesis. Eight strain gauges and two piezoresistive sensors were used and placed suitably in the artificial disk prosthesis. The results from the in-vitro loading showed linear relationship between loading and the outputs from the sensors with good repeatability and less hysteresis.

Personalized medicine: from genotypes, molecular phenotypes and the quantified self, towards improved medicine.

Science.gov (United States)

Dudley, Joel T; Listgarten, Jennifer; Stegle, Oliver; Brenner, Steven E; Parts, Leopold

2015-01-01

Advances in molecular profiling and sensor technologies are expanding the scope of personalized medicine beyond genotypes, providing new opportunities for developing richer and more dynamic multi-scale models of individual health. Recent studies demonstrate the value of scoring high-dimensional microbiome, immune, and metabolic traits from individuals to inform personalized medicine. Efforts to integrate multiple dimensions of clinical and molecular data towards predictive multi-scale models of individual health and wellness are already underway. Improved methods for mining and discovery of clinical phenotypes from electronic medical records and technological developments in wearable sensor technologies present new opportunities for mapping and exploring the critical yet poorly characterized "phenome" and "envirome" dimensions of personalized medicine. There are ambitious new projects underway to collect multi-scale molecular, sensor, clinical, behavioral, and environmental data streams from large population cohorts longitudinally to enable more comprehensive and dynamic models of individual biology and personalized health. Personalized medicine stands to benefit from inclusion of rich new sources and dimensions of data. However, realizing these improvements in care relies upon novel informatics methodologies, tools, and systems to make full use of these data to advance both the science and translational applications of personalized medicine.

[The gitaigo personality scale for description of self and others].

Science.gov (United States)

Komatsu, Koji; Sakai, Keiko; Nishioka, Miwa; Mukoyama, Yasuyo

2012-06-01

Gitaigo is a subtype of mimetic words (onomatopoeia) in the Japanese language, which can be regarded as words that imitate actions or states. This study develops a personality scale, with six subscales, using 60 gitaigo words as items for rating the personality of the self and others. We asked 1 054 participants to rate their own personality and 905 participants to rate a close friend's personality, using 158 gitaigo words as items to describe personality. We found that a six-factor model, found in our previous study, was also applicable to the present study of ratings of participants' own personality. We also found six groups of words in the ratings of close friends' personality, although the factor structure is slightly different from the self-rating factors. We selected ten words that exhibited high loadings for each of the six factors to develop a personality scale with six subscales showing high reliability. We named those factors: cowardliness, slowness, preciseness, irritableness, candidness, and frivolousness. The average scores for self-ratings were significantly lower for two subscales (preciseness and candidness) and higher for other four subscales compared to the rating of others.

Tomotherapy archive structure and new software tool for loading and advanced analysis of data contained in it

International Nuclear Information System (INIS)

Ryczkowski, A.; Piotrowski, T.

2011-01-01

Aim: The main objective of the study was to analyze the structure of data contained in the archives exported from a tomotherapy treatment planning system. An additional aim was to create an application equipped with a user-friendly interface to enable automatic reading of files and data analysis, also using external algorithms. Analyses had to include image registration, dose deformation and summation. Materials and methods: Files from the archive exported from the tomotherapy treatment planning system (TPS) were analyzed. Two programs were used to analyze the information contained in the archive files: XML Viewer by Mind Fusion Limited and H x D hex editor by Mael Hora. To create an application enabling loading and analyzing the data, Matlab by MathWorks, version R2009b, was used. Results: Archive exported from the TPS is a directory with several files. It contains three types of data: .xml, .img and .sin. Tools available in Matlab offer great opportunities for analysis and transformation of loaded information. Proposed application automates the loading of necessary information and simplifies data handling. Furthermore, the application is equipped with a graphical user interface (GUI). The main application window contains buttons for opening the archives and analyzing the loaded data. Conclusion: The analysis of data contained in the archive exported from the tomotherapy treatment planning system allowed to determine the way and place of saving information of our interest, such as tomography images, structure sets and dose distributions. This enabled us to develop and optimize methods of loading and analyzing this information. (authors)

Technical Potential for Peak Load Management Programs in New Jersey

Energy Technology Data Exchange (ETDEWEB)

Kirby, B.J.

2002-12-13

Restructuring is attempting to bring the economic efficiency of competitive markets to the electric power industry. To at least some extent it is succeeding. New generation is being built in most areas of the country reversing the decades-long trend of declining reserve margins. Competition among generators is typically robust, holding down wholesale energy prices. Generators have shown that they are very responsive to price signals in both the short and long term. But a market that is responsive only on the supply side is only half a market. Demand response (elasticity) is necessary to gain the full economic advantages that restructuring can offer. Electricity is a form of energy that is difficult to store economically in large quantities. However, loads often have some ability to (1) conveniently store thermal energy and (2) defer electricity consumption. These inherent storage and control capabilities can be exploited to help reduce peak electric system consumption. In some cases they can also be used to provide system reliability reserves. Fortunately too, technology is helping. Advances in communications and control technologies are making it possible for loads ranging from residential through commercial and industrial to respond to economic signals. When we buy bananas, we don't simply take a dozen and wait a month to find out what the price was. We always ask about the price before we decide how many bananas we want. Technology is beginning to allow at least some customers to think about their electricity consumption the same way they think about most of their other purchases. And power system operators and regulators are beginning to understand that customers need to remain in control of their own destinies. Many customers (residential through industrial) are willing to respond to price signals. Most customers are not able to commit to specific responses months or years in advance. Electricity is a fluid market commodity with a volatile value to both

New advances in cystic fibrosis - implications for developing countries

African Journals Online (AJOL)

New advances in cystic fibrosis - implications for developing countries. Heather J Zar, Eric Bateman, Michelle Ramsay. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM.

The Relationship between Iranian EFL Advanced Learners' Personality Types, Motivation and Language Learning Success

Directory of Open Access Journals (Sweden)

Marzieh Ebrahimi

2016-05-01

Full Text Available Affective factors are the most important factors in SLA and EFL studies. These factors include motivation, self-confidence, anxiety, etc. Researches on learners’ characteristics have been investigated for over a century. In the same vein, the present research, strived at exploring Iranian’s EFL learners personality types and motivation. In the article, the personality types and motivation of students were examined using Myers-Briggs Type Indicator (MBTI and motivation questionnaire of Laine. For this purpose, 60 EFL students from one of the language institutions Mashhad (located in Iran were chosen as  the participants of this study. Through two instruments and considering the participants’ previous semester scores, the data were gathered and analyzed by means of SPSS software. The correctional analyses revealed a significant relationship among motivation, personality and students’ success. Multiple regression analysis was also conducted to examine the strength of the relationship among the variables. Among the affective factors, personality type was found to be the best predictor of students’ success. The study provides some pedagogical implications and suggestions for future research.

Design and Optimization of a Composite Canard Control Surface of an Advanced Fighter Aircraft under Static Loading

Directory of Open Access Journals (Sweden)

Shrivastava Sachin

2015-01-01

Full Text Available The minimization of weight and maximization of payload is an ever challenging design procedure for air vehicles. The present study has been carried out with an objective to redesign control surface of an advanced all-metallic fighter aircraft. In this study, the structure made up of high strength aluminum, titanium and ferrous alloys has been attempted to replace by carbon fiber composite (CFC skin, ribs and stiffeners. This study presents an approach towards development of a methodology for optimization of first-ply failure index (FI in unidirectional fibrous laminates using Genetic-Algorithms (GA under quasi-static loading. The GAs, by the application of its operators like reproduction, cross-over, mutation and elitist strategy, optimize the ply-orientations in laminates so as to have minimum FI of Tsai-Wu first-ply failure criterion. The GA optimization procedure has been implemented in MATLAB and interfaced with commercial software ABAQUS using python scripting. FI calculations have been carried out in ABAQUS with user material subroutine (UMAT. The GA's application gave reasonably well-optimized ply-orientations combination at a faster convergence rate. However, the final optimized sequence of ply-orientations is obtained by tweaking the sequences given by GA's based on industrial practices and experience, whenever needed. The present study of conversion of an all metallic structure to partial CFC structure has led to 12% of weight reduction. Therefore, the approach proposed here motivates designer to use CFC with a confidence.

What Works in the Treatment of Borderline Personality Disorder

OpenAIRE

Choi-Kain, Lois W.; Finch, Ellen F.; Masland, Sara R.; Jenkins, James A.; Unruh, Brandon T.

2017-01-01

Purpose of the Review This review summarizes advances in treatments for adults with borderline personality disorder (BPD) in the last 5?years. Recent Findings Evidence-based advances in the treatment of BPD include a delineation of generalist models of care in contrast to specialist treatments, identification of essential effective elements of dialectical behavioral therapy (DBT), and the adaptation of DBT treatment to manage post-traumatic stress disorder (PTSD) and BPD. Studies on pharmacol...

Assessing Person-Centered Outcomes in Practice Research: A Latent Transition Profile Framework

Science.gov (United States)

Thompson, Aaron M.; Macy, Rebecca J.; Fraser, Mark W.

2011-01-01

Advances in statistics provide new methods for analyzing practice data. These advances include person-centered methods (PCMs) that identify subgroups of research participants with similar characteristics. PCMs derive from a frame of reference that is similar to the risk factor perspective in practice. In practice, the delivery of services is often…

Load Sharing Behavior of Star Gearing Reducer for Geared Turbofan Engine

Science.gov (United States)

Mo, Shuai; Zhang, Yidu; Wu, Qiong; Wang, Feiming; Matsumura, Shigeki; Houjoh, Haruo

2017-07-01

Load sharing behavior is very important for power-split gearing system, star gearing reducer as a new type and special transmission system can be used in many industry fields. However, there is few literature regarding the key multiple-split load sharing issue in main gearbox used in new type geared turbofan engine. Further mechanism analysis are made on load sharing behavior among star gears of star gearing reducer for geared turbofan engine. Comprehensive meshing error analysis are conducted on eccentricity error, gear thickness error, base pitch error, assembly error, and bearing error of star gearing reducer respectively. Floating meshing error resulting from meshing clearance variation caused by the simultaneous floating of sun gear and annular gear are taken into account. A refined mathematical model for load sharing coefficient calculation is established in consideration of different meshing stiffness and supporting stiffness for components. The regular curves of load sharing coefficient under the influence of interactions, single action and single variation of various component errors are obtained. The accurate sensitivity of load sharing coefficient toward different errors is mastered. The load sharing coefficient of star gearing reducer is 1.033 and the maximum meshing force in gear tooth is about 3010 N. This paper provides scientific theory evidences for optimal parameter design and proper tolerance distribution in advanced development and manufacturing process, so as to achieve optimal effects in economy and technology.

The presence of advanced lesions and associating risk factors for advanced cervical carcinoma in patients with atypical sguamous cells of undetermined significance.

Science.gov (United States)

Sun, L L; Chen, W; Fan, Y Y; Wang, M L; Wang, L N

2015-01-01

To characterize histopathological status, high-risk human papillomavirus (hr-HPV) infection status, and associated risk factors in patients with atypical squamous cells of undetermined significance (ASCUS). Cervical biopsies obtained from 130 ASCUS patients were subjected to histopathological examination and hr-HPV testing. Associations between advanced lesions and hr-HPV load or age were analyzed, and the confounding factors for high-grade cervical lesions were identified. Cervical biopsies from ASCUS patients had a wide range of pathological states, ranging from normal to invasive cervical carcinoma. High-risk HPV infection was significantly associated with advanced cervical lesions in ASCUS patients; hr-HPV infection and the number of gestations were risk factors for developing advanced cervical disease. A significant portion of ASCUS patients harbor advanced cervical lesions. The number of gestations and hr-HPV infection can increase the risk of developing advanced cervical lesions in ASCUS patients.

Performance of Railway Sleepers with Holes under Impact Loading

Science.gov (United States)

Lim, Chie Hong; Kaewunruen, Sakdirat; Mlilo, Nhlanganiso

2017-12-01

Prestressed concrete sleepers are essential structural components of railway track structures, with the purpose of redistributing wheel loads from the rails to the ground. To facilitate cables and signalling equipment, holes are often generated in these prestressed concrete sleepers. However, the performance of these sleepers under impact loading may be a concern with the addition of these holes. Numerical modelling using finite element analysis (FEA) is an ideal tool that enables static and dynamic simulation and can perform analyses of basic/advanced linear and nonlinear problems, without incurring a huge cost in resources like standard experimental test methods would. This paper will utilize the three-dimensional FE modelling software ABAQUS to investigate the behaviour of the prestressed concrete sleepers with holes of varying sizes upon impact loading. To obtain the results that resemble real-life behaviour of the sleepers under impact loading, the material properties, element types, mesh sizes, contact and interactions and boundary conditions will be defined as accurately as possible. Both Concrete Damaged Plasticity (CDP) and Brittle Cracking models will be used in this study. With a better understanding of how the introduction of holes will influence the performance of prestressed sleepers under impact loading, track and railway engineers will be able to generate them in prestressed concrete sleepers without compromising the sleepers’ performance during operation

Accurate green water loads calculation using naval hydro pack

Science.gov (United States)

Jasak, H.; Gatin, I.; Vukčević, V.

2017-12-01

An extensive verification and validation of Finite Volume based CFD software Naval Hydro based on foam-extend is presented in this paper for green water loads. Two-phase numerical model with advanced methods for treating the free surface is employed. Pressure loads on horizontal deck of Floating Production Storage and Offloading vessel (FPSO) model are compared to experimental results from [1] for three incident regular waves. Pressure peaks and integrals of pressure in time are measured on ten different locations on deck for each case. Pressure peaks and integrals are evaluated as average values among the measured incident wave periods, where periodic uncertainty is assessed for both numerical and experimental results. Spatial and temporal discretization refinement study is performed providing numerical discretization uncertainties.

From old concerns to new advances and personalized medicine in lupus: The end of the tunnel is approaching.

Science.gov (United States)

Doria, Andrea; Gershwin, M Eric; Selmi, Carlo

2016-11-01

The significant decrease in mortality rates worldwide, the increased proportion of patients achieving a durable remission, and the recent approval of a new drug after several decades are encouraging advances in the tangled history of systemic lupus erythematosus (SLE). However, when data are observed more closely, the research findings on disease pathogenesis and targeted treatments have been quite misleading, as illustrated by the central role of B cells but the missed endpoints in rituximab clinical trials which are burdened by the wide variability of SLE manifestations or the ethnic determinants of disease severity. Other biologic therapies, on the other hand, inhibit B cell stimulating factor BAFF but are proving to be short of revolutionary, not yet overcoming high-dose long-term glucocorticoids still largely used without an agreement on what clinical targets are to be sought in the proposed treat-to-target approach. The large amount of data from genome-wide association studies, the detailed reports on T cell epigenetics, or the numerous established and novel animal models have also proven insufficient to change our understanding of the human disease. Nonetheless, we have now tools for a better and earlier SLE diagnosis, thanks to reliable biomarkers, improved care of kidney involvement, better pregnancy outcomes, while the neuropsychiatric manifestations remain challenging. These advances are well mirrored by some proposed synthetic drugs, such as tacrolimus, or biologics, including IFNα inhibitors and other drugs capable to modulate the immune system. Ultimately, we may foresee that genetic and epigenetic data, along with the variable clinical manifestations represent the bases for SLE to become an ideal candidate for the introduction of truly personalized medicine. Copyright © 2016 Elsevier Ltd. All rights reserved.

International Conference on Computers and Advanced Technology in Education

CERN Document Server

Advanced Information Technology in Education

2012-01-01

The volume includes a set of selected papers extended and revised from the 2011 International Conference on Computers and Advanced Technology in Education. With the development of computers and advanced technology, the human social activities are changing basically. Education, especially the education reforms in different countries, has been experiencing the great help from the computers and advanced technology. Generally speaking, education is a field which needs more information, while the computers, advanced technology and internet are a good information provider. Also, with the aid of the computer and advanced technology, persons can make the education an effective combination. Therefore, computers and advanced technology should be regarded as an important media in the modern education. Volume Advanced Information Technology in Education is to provide a forum for researchers, educators, engineers, and government officials involved in the general areas of computers and advanced technology in education to d...

Personal Rotorcraft Design and Performance with Electric Hybridization

Science.gov (United States)

Snyder, Christopher A.

2017-01-01

Recent and projected improvements for more or all-electric aviation propulsion systems can enable greater personal mobility, while also reducing environmental impact (noise and emissions). However, all-electric energy storage capability is significantly less than present, hydrocarbon-fueled systems. A system study was performed exploring design and performance assuming hybrid propulsion ranging from traditional hydrocarbon-fueled cycles (gasoline Otto and diesel) to all-electric systems using electric motors generators, with batteries for energy storage and load leveling. Study vehicles were a conventional, single-main rotor (SMR) helicopter and an advanced vertical takeoff and landing (VTOL) aircraft. Vehicle capability was limited to two or three people (including pilot or crew); the design range for the VTOL aircraft was set to 150 miles (about one hour total flight). Search and rescue (SAR), loiter, and cruise-dominated missions were chosen to illustrate each vehicle and degree of hybrid propulsion strengths and weaknesses. The traditional, SMR helicopter is a hover-optimized design; electric hybridization was performed assuming a parallel hybrid approach by varying degree of hybridization. Many of the helicopter hybrid propulsion combinations have some mission capabilities that might be effective for short range or on-demand mobility missions. However, even for 30 year technology electrical components, all hybrid propulsion systems studied result in less available fuel, lower maximum range, and reduced hover and loiter duration than the baseline vehicle. Results for the VTOL aircraft were more encouraging. Series hybrid combinations reflective of near-term systems could improve range and loiter duration by 30. Advanced, higher performing series hybrid combinations could double or almost triple the VTOL aircrafts range and loiter duration. Additional details on the study assumptions and work performed are given, as well as suggestions for future study effort.

eConsent management and enforcement in personal telehealth

NARCIS (Netherlands)

Asim, M.; Koster, R.P.; Petkovic, M.; Rosner, M.; Reimer, H.; Pohlmann, N.; Schneider, W.

2013-01-01

Advances in information and communication technologies are expected to bring large benefits in the healthcare domain. Personal telehealth is one such example that has the potential to address some of the important challenges currently faced by healthcare such as improvement in the quality of

Challenges, Solutions, and Quality Metrics of Personal Genome Assembly in Advancing Precision Medicine

Directory of Open Access Journals (Sweden)

Wenming Xiao

2016-04-01

Full Text Available Even though each of us shares more than 99% of the DNA sequences in our genome, there are millions of sequence codes or structure in small regions that differ between individuals, giving us different characteristics of appearance or responsiveness to medical treatments. Currently, genetic variants in diseased tissues, such as tumors, are uncovered by exploring the differences between the reference genome and the sequences detected in the diseased tissue. However, the public reference genome was derived with the DNA from multiple individuals. As a result of this, the reference genome is incomplete and may misrepresent the sequence variants of the general population. The more reliable solution is to compare sequences of diseased tissue with its own genome sequence derived from tissue in a normal state. As the price to sequence the human genome has dropped dramatically to around $1000, it shows a promising future of documenting the personal genome for every individual. However, de novo assembly of individual genomes at an affordable cost is still challenging. Thus, till now, only a few human genomes have been fully assembled. In this review, we introduce the history of human genome sequencing and the evolution of sequencing platforms, from Sanger sequencing to emerging “third generation sequencing” technologies. We present the currently available de novo assembly and post-assembly software packages for human genome assembly and their requirements for computational infrastructures. We recommend that a combined hybrid assembly with long and short reads would be a promising way to generate good quality human genome assemblies and specify parameters for the quality assessment of assembly outcomes. We provide a perspective view of the benefit of using personal genomes as references and suggestions for obtaining a quality personal genome. Finally, we discuss the usage of the personal genome in aiding vaccine design and development, monitoring host

IMPROVEMENT OF PERFORMANCE OF DUAL FUEL ENGINE OPERATED AT PART LOAD

Directory of Open Access Journals (Sweden)

N. Kapilan

2010-12-01

Full Text Available Rising petroleum prices, an increasing threat to the environment from exhaust emissions, global warming and the threat of supply instabilities has led to the choice of inedible Mahua oil (MO as one of the main alternative fuels to diesel oil in India. In the present work, MO was converted into biodiesel by transesterification using methanol and sodium hydroxide. The cost of Mahua oil biodiesel (MOB is higher than diesel. Hence liquefied petroleum gas (LPG, which is one of the cheapest gaseous fuels available in India, was fumigated along with the air to reduce the operating cost and to reduce emissions. The dual fuel engine resulted in lower efficiency and higher emissions at part load. Hence in the present work, the injection time was varied and the performance of the dual fuel engine was studied. From the engine tests, it is observed that an advanced injection time results in higher efficiency and lower emissions. Hence, advancing the injection timing is one of the ways of increasing the efficiency of LPG+MOB dual fuel engine operated at part load.

Personality traits beyond the big five: are they within the HEXACO space?

Science.gov (United States)

Lee, Kibeom; Ogunfowora, Babatunde; Ashton, Michael C

2005-10-01

Paunonen (2002) recently developed the Supernumerary Personality Inventory (SPI), a measure of 10 traits that have low loadings within the space of the Big Five personality factors. If the SPI personality traits are representative of the domain of non-Big Five personality traits, then the major source of the variance in the SPI traits would be expected to correlate strongly with the sixth factor of personality, Honesty-Humility. We tested this hypothesis using self-report measures (N = 200) of the SPI traits, of the Big Five, and of the new six-dimensional ("HEXACO") structure. Results indicated that the first unrotated factor underlying the 10 SPI traits was heavily saturated with variance from Honesty-Humility (r = .65). Nevertheless, the 10 SPI traits contained substantial amounts of unique variance not accounted for by the HEXACO or the Big Five variables, highlighting the importance of the facet-level assessment of personality traits.

Cognitive Load Theory: implications for medical education: AMEE Guide No. 86.

Science.gov (United States)

Young, John Q; Van Merrienboer, Jeroen; Durning, Steve; Ten Cate, Olle

2014-05-01

Cognitive Load Theory (CLT) builds upon established models of human memory that include the subsystems of sensory, working and long-term memory. Working memory (WM) can only process a limited number of information elements at any given time. This constraint creates a "bottleneck" for learning. CLT identifies three types of cognitive load that impact WM: intrinsic load (associated with performing essential aspects of the task), extraneous load (associated with non-essential aspects of the task) and germane load (associated with the deliberate use of cognitive strategies that facilitate learning). When the cognitive load associated with a task exceeds the learner's WM capacity, performance and learning is impaired. To facilitate learning, CLT researchers have developed instructional techniques that decrease extraneous load (e.g. worked examples), titrate intrinsic load to the developmental stage of the learner (e.g. simplify task without decontextualizing) and ensure that unused WM capacity is dedicated to germane load, i.e. cognitive learning strategies. A number of instructional techniques have been empirically tested. As learners' progress, curricula must also attend to the expertise-reversal effect. Instructional techniques that facilitate learning among early learners may not help and may even interfere with learning among more advanced learners. CLT has particular relevance to medical education because many of the professional activities to be learned require the simultaneous integration of multiple and varied sets of knowledge, skills and behaviors at a specific time and place. These activities possess high "element interactivity" and therefore impose a cognitive load that may surpass the WM capacity of the learner. Applications to various medical education settings (classroom, workplace and self-directed learning) are explored.

Man-machine interface requirements - advanced technology

Science.gov (United States)

Remington, R. W.; Wiener, E. L.

1984-01-01

Research issues and areas are identified where increased understanding of the human operator and the interaction between the operator and the avionics could lead to improvements in the performance of current and proposed helicopters. Both current and advanced helicopter systems and avionics are considered. Areas critical to man-machine interface requirements include: (1) artificial intelligence; (2) visual displays; (3) voice technology; (4) cockpit integration; and (5) pilot work loads and performance.

Biomarker Testing for Personalized Therapy in Lung Cancer in Low- and Middle-Income Countries.

Science.gov (United States)

Hirsch, Fred R; Zaric, Bojan; Rabea, Ahmed; Thongprasert, Sumitra; Lertprasertsuke, Nirush; Dalurzo, Mercedes Liliana; Varella-Garcia, Marileila

2017-01-01

There have been many important advances in personalized therapy for patients with lung cancer, particularly for those with advanced disease. Molecular testing is crucial for implementation of personalized therapy. Although the United States and many Western countries have come far in the implementation of personalized therapy for lung cancer, there are substantial challenges for low- and middle-income countries (LMICs). Globally, the LMICs display great heterogeneity in the pattern of implementation of molecular testing and targeted therapy. The current review presents an attempt to identify the challenges and obstacles for the implementation of molecular testing and the use of targeted therapies in these areas. Lack of infrastructure, lack of technical expertise, economic factors, and lack of access to new drugs are among the substantial barriers.

The internet of things for personalized health.

Science.gov (United States)

Schreier, Günter

2014-01-01

Advances in information and communications technologies (ICT) enable new personalized health care concepts which are often characterized by four "P" terms, i.e. personalized, predictive, preventive and participatory. However, real world implementations of the complete 4P spectrum hardly exist today. The Internet of Things (IoT) has been defined as an extension to the current Internet that enables pervasive communication between the physical and the virtual world. Smart devices and enabling elements like Near Field Communication (NFC) and Radio Frequency Identification (RFID) technology already exist and increasingly will be a mainstream element of our lives. This future vision paper attempts to assess if and how the Internet of Things for personalized health (IoT4pH) can help to facilitate the 4P healthcare paradigm and discusses related challenges and opportunities.

Advance statements for borderline personality disorder: a qualitative study of future crisis treatment preferences.

Science.gov (United States)

Borschmann, Rohan; Trevillion, Kylee; Henderson, R Claire; Rose, Diana; Szmukler, George; Moran, Paul

2014-06-01

Little is known about the crisis treatment preferences of people with borderline personality disorder. Clinicians may also question service users' ability to make considered decisions about their treatment when in crisis. Therefore, this qualitative study aimed to investigate crisis treatment preferences of a sample of community-dwelling adults with borderline personality disorder. Participants were 41 adults with borderline personality disorder who had created joint crisis plans during a randomized controlled trial. Data from all 41 joint crisis plans were analyzed iteratively via a thematic analysis framework. Participants gave clear statements in their crisis plans relating to the desire to recover from the crisis and to improve their social functioning. Key themes included the desire to be treated with dignity and respect and to receive emotional and practical support from clinicians. Many participants spoke of the importance of connecting with others during periods of crisis, but several reported a clear desire to be left alone during a future crisis. Other themes concerned preferences for specific treatment refusals during crises, including particular types of psychotropic medication and involuntary treatment. The variation of participants' preferences underscores the importance of developing individually tailored crisis plans for people with borderline personality disorder. The need to be treated with dignity and respect and to be given autonomy in decision making--also identified in global surveys of people with severe mental illness--is important to people with borderline personality disorder. Key messages for clinicians, service users, and policy makers, in addition to staff training issues, are discussed.

The Use of Personal Data Assistants in Early Childhood Assessment

Science.gov (United States)

Ledoux, Michael W.; Yoder, Noreen N.; Hanes, Barbara

2010-01-01

Four early childhood education teachers, two veteran and two newer teachers, were asked to pilot the use of handheld Personal Data Assistants loaded with Childchart assessment software. The participants were observed in their use of the electronic devices for monitoring student performance and interviewed regarding the use of the devices and their…

Coordinating plug-in electric vehicle charging with electric grid: Valley filling and target load following

Science.gov (United States)

Zhang, Li; Jabbari, Faryar; Brown, Tim; Samuelsen, Scott

2014-12-01

Plug-in electric vehicles (PEVs) shift energy consumption from petroleum to electricity for the personal transportation sector. This work proposes a decentralized charging protocol for PEVs with grid operators updating the cost signal. Each PEV calculates its own optimal charging profile only once based on the cost signal, after it is plugged in, and sends the result back to the grid operators. Grid operators only need to aggregate charging profiles and update the load and cost. The existing PEV characteristics, national household travel survey (NHTS), California Independent System Operator (CAISO) demand, and estimates for future renewable generation in California are used to simulate PEV operation, PEV charging profiles, grid demand, and grid net load (demand minus renewable). Results show the proposed protocol has good performance for overnight net load valley filling if the costs to be minimized are proportional to the net load. Annual results are shown in terms of overnight load variation and comparisons are made with grid level valley filling results. Further, a target load can be approached in the same manner by using the gap between current load and the target load as the cost. The communication effort involved is quite modest.

Distribution load forecast with interactive correction of horizon loads

International Nuclear Information System (INIS)

Glamochanin, V.; Andonov, D.; Gagovski, I.

1994-01-01

This paper presents the interactive distribution load forecast application that performs the distribution load forecast with interactive correction of horizon loads. It consists of two major parts implemented in Fortran and Visual Basic. The Fortran part is used for the forecasts computations. It consists of two methods: Load Transfer Coupling Curve Fitting (LTCCF) and load Forecast Using Curve Shape Clustering (FUCSC). LTCCF is used to 'correct' the contaminated data because of load transfer among neighboring distribution areas. FUCSC uses curve shape clustering to forecast the distribution loads of small areas. The forecast for each small area is achieved by using the shape of corresponding cluster curve. The comparison of forecasted loads of the area with historical data will be used as a tool for the correction of the estimated horizon load. The Visual Basic part is used to provide flexible interactive user-friendly environment. (author). 5 refs., 3 figs

Load-cell based characterization system for a “Violin-Mode” shadow-sensor in advanced LIGO suspensions

Energy Technology Data Exchange (ETDEWEB)

Lockerbie, N. A.; Tokmakov, K. V. [SUPA (Scottish Universities Physics Alliance) Department of Physics, University of Strathclyde, 107 Rottenrow, Glasgow G4 0NG (United Kingdom)

2016-07-15

The background to this work was a prototype shadow sensor, which was designed for retro-fitting to an advanced LIGO (Laser Interferometer Gravitational wave Observatory) test-mass/mirror suspension, in which 40 kg test-mass/mirrors are each suspended by four approximately 600 mm long by 0.4 mm diameter fused-silica suspension fibres. The shadow sensor comprised a LED source of Near InfraRed (NIR) radiation and a rectangular silicon photodiode detector, which, together, were to bracket the fibre under test. The aim was to detect transverse Violin-Mode resonances in the suspension fibres. Part of the testing procedure involved tensioning a silica fibre sample and translating it transversely through the illuminating NIR beam, so as to measure the DC responsivity of the detection system to fibre displacement. However, an equally important part of the procedure, reported here, was to keep the fibre under test stationary within the beam, whilst trying to detect low-level AC Violin-Mode resonances excited on the fibre, in order to confirm the primary function of the sensor. Therefore, a tensioning system, incorporating a load-cell readout, was built into the test fibre’s holder. The fibre then was excited by a signal generator, audio power amplifier, and distant loudspeaker, and clear resonances were detected. A theory for the expected fundamental resonant frequency as a function of fibre tension was developed and is reported here, and this theory was found to match closely with the detected resonant frequencies as they varied with tension. Consequently, the resonances seen were identified as being proper Violin-Mode fundamental resonances of the fibre, and the operation of the Violin-Mode detection system was validated.

Load-cell based characterization system for a “Violin-Mode” shadow-sensor in advanced LIGO suspensions

International Nuclear Information System (INIS)

Lockerbie, N. A.; Tokmakov, K. V.

2016-01-01

The background to this work was a prototype shadow sensor, which was designed for retro-fitting to an advanced LIGO (Laser Interferometer Gravitational wave Observatory) test-mass/mirror suspension, in which 40 kg test-mass/mirrors are each suspended by four approximately 600 mm long by 0.4 mm diameter fused-silica suspension fibres. The shadow sensor comprised a LED source of Near InfraRed (NIR) radiation and a rectangular silicon photodiode detector, which, together, were to bracket the fibre under test. The aim was to detect transverse Violin-Mode resonances in the suspension fibres. Part of the testing procedure involved tensioning a silica fibre sample and translating it transversely through the illuminating NIR beam, so as to measure the DC responsivity of the detection system to fibre displacement. However, an equally important part of the procedure, reported here, was to keep the fibre under test stationary within the beam, whilst trying to detect low-level AC Violin-Mode resonances excited on the fibre, in order to confirm the primary function of the sensor. Therefore, a tensioning system, incorporating a load-cell readout, was built into the test fibre’s holder. The fibre then was excited by a signal generator, audio power amplifier, and distant loudspeaker, and clear resonances were detected. A theory for the expected fundamental resonant frequency as a function of fibre tension was developed and is reported here, and this theory was found to match closely with the detected resonant frequencies as they varied with tension. Consequently, the resonances seen were identified as being proper Violin-Mode fundamental resonances of the fibre, and the operation of the Violin-Mode detection system was validated.

Calculation and mapping of critical loads in Europe: Status report 1993

International Nuclear Information System (INIS)

Downing, R.J.; Hettelingh, J.P.; De Smet, P.A.M.

1993-01-01

The work of the RIVM Coordination Center for Effects (CCE) and National Focal Centers (NFCs) for Mapping over the past two years is summarized. The primary task of the critical loads mapping program during this period was to compute and map critical loads of sulphur in Europe. Efforts were undertaken to enhance the scientific foundations and policy relevance of the critical load program, and to foster consensus among producers and users of this information by means of three workshops. The applied calculation methods are described, as well as the resulting critical loads maps, based upon the outcomes of the workshops. Chapter 2 contains the most recent maps (May 1993) of the critical load of acidity as well as the critical load of sulphur and critical sulphur deposition, which are derived from the critical load of acidity. The chapter also contains maps of the sulphur deposition in Europe in 1980 and 1990, and the resulting exceedances. In chapter 3 the methods and equations used to derive the maps of critical loads and exceedances of acidity and sulphur are described with emphasis on the advances in the calculation methods used since the first European critical loads maps were produced in 1991. In chapter 4 the methods to be used to compute and map critical loads in the future are presented. In chapter 5 an overview of the data inputs is given, and the methods of data handling performed by the CCE to produce the current European maps of critical loads. In chapter 6 the results of an uncertainty analysis is described, which was performed on the critical loads computation methodology to assess the reliability of the computation results and the importance of the various input variables. Chapter 7 provides some conclusions and recommendations resulting from the critical load mapping activities. In Appendix 1 the reports of the can be found, with additional maps of critical loads and background variables in Appendix 2. 15 figs., 11 tabs., 156 refs

Advanced electrical power system technology for the all electric aircraft

Science.gov (United States)

Finke, R. C.; Sundberg, G. R.

1983-01-01

The application of advanced electric power system technology to an all electric airplane results in an estimated reduction of the total takeoff gross weight of over 23,000 pounds for a large airplane. This will result in a 5 to 10 percent reduction in direct operating costs (DOC). Critical to this savings is the basic electrical power system component technology. These advanced electrical power components will provide a solid foundation for the materials, devices, circuits, and subsystems needed to satisfy the unique requirements of advanced all electric aircraft power systems. The program for the development of advanced electrical power component technology is described. The program is divided into five generic areas: semiconductor devices (transistors, thyristors, and diodes); conductors (materials and transmission lines); dielectrics; magnetic devices; and load management devices. Examples of progress in each of the five areas are discussed. Bipolar power transistors up to 1000 V at 100 A with a gain of 10 and a 0.5 microsec rise and fall time are presented. A class of semiconductor devices with a possibility of switching up to 100 kV is described. Solid state power controllers for load management at 120 to 1000 V and power levels to 25 kW were developed along with a 25 kW, 20 kHz transformer weighing only 3.2 kg. Previously announced in STAR as N83-24764

Advanced electrical power system technology for the all electric aircraft

Science.gov (United States)

Finke, R. C.; Sundberg, G. R.

1983-01-01

The application of advanced electric power system technology to an all electric airplane results in an estimated reduction of the total takeoff gross weight of over 23,000 pounds for a large airplane. This will result in a 5 to 10 percent reduction in direct operating costs (DOC). Critical to this savings is the basic electrical power system component technology. These advanced electrical power components will provide a solid foundation for the materials, devices, circuits, and subsystems needed to satisfy the unique requirements of advanced all electric aircraft power systems. The program for the development of advanced electrical power component technology is described. The program is divided into five generic areas: semiconductor devices (transistors, thyristors, and diodes); conductors (materials and transmission lines); dielectrics; magnetic devices; and load management devices. Examples of progress in each of the five areas are discussed. Bipolar power transistors up to 1000 V at 100 A with a gain of 10 and a 0.5 microsec rise and fall time are presented. A class of semiconductor devices with a possibility of switching up to 100 kV is described. Solid state power controllers for load management at 120 to 1000 V and power levels to 25 kW were developed along with a 25 kW, 20 kHz transformer weighing only 3.2 kg.

Optimal Residential Load Scheduling Under Utility and Rooftop Photovoltaic Units

Directory of Open Access Journals (Sweden)

Ghulam Hafeez

2018-03-01

Full Text Available With the rapid advancement in technology, electrical energy consumption is increasing rapidly. Especially, in the residential sector, more than 80% of electrical energy is being consumed because of consumer negligence. This brings the challenging task of maintaining the balance between the demand and supply of electric power. In this paper, we focus on the problem of load balancing via load scheduling under utility and rooftop photovoltaic (PV units to reduce electricity cost and peak to average ratio (PAR in demand-side management. For this purpose, we adopted genetic algorithm (GA, binary particle swarm optimization (BPSO, wind-driven optimization (WDO, and our proposed genetic WDO (GWDO algorithm, which is a hybrid of GA and WDO, to schedule the household load. For energy cost estimation, combined real-time pricing (RTP and inclined block rate (IBR were used. The proposed algorithm shifts load from peak consumption hours to off-peak hours based on combined pricing scheme and generation from rooftop PV units. Simulation results validate our proposed GWDO algorithm in terms of electricity cost and PAR reduction while considering all three scenarios which we have considered in this work: (1 load scheduling without renewable energy sources (RESs and energy storage system (ESS, (2 load scheduling with RESs, and (3 load scheduling with RESs and ESS. Furthermore, our proposed scheme reduced electricity cost and PAR by 22.5% and 29.1% in scenario 1, 47.7% and 30% in scenario 2, and 49.2% and 35.4% in scenario 3, respectively, as compared to unscheduled electricity consumption.

Modeling and Analysis of Commercial Building Electrical Loads for Demand Side Management

Science.gov (United States)

Berardino, Jonathan

In recent years there has been a push in the electric power industry for more customer involvement in the electricity markets. Traditionally the end user has played a passive role in the planning and operation of the power grid. However, many energy markets have begun opening up opportunities to consumers who wish to commit a certain amount of their electrical load under various demand side management programs. The potential benefits of more demand participation include reduced operating costs and new revenue opportunities for the consumer, as well as more reliable and secure operations for the utilities. The management of these load resources creates challenges and opportunities to the end user that were not present in previous market structures. This work examines the behavior of commercial-type building electrical loads and their capacity for supporting demand side management actions. This work is motivated by the need for accurate and dynamic tools to aid in the advancement of demand side operations. A dynamic load model is proposed for capturing the response of controllable building loads. Building-specific load forecasting techniques are developed, with particular focus paid to the integration of building management system (BMS) information. These approaches are tested using Drexel University building data. The application of building-specific load forecasts and dynamic load modeling to the optimal scheduling of multi-building systems in the energy market is proposed. Sources of potential load uncertainty are introduced in the proposed energy management problem formulation in order to investigate the impact on the resulting load schedule.

FY 1999 report on the results of the experimental verification on the establishment of a centralized load control system. Study of an advanced centralized load control system, etc.; 1999 nendo fuka shuchu seigyo system kakuritsu jissho shikehn kodo fuka shuchu seigyo system nado no kenkyu. Fuka shuchu seigyo system kakuritsu jissho shiken

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

The paper described the FY 1999 results of the experimental verification on a centralized load control system for the residential electric power demand. The air conditioning control is effective for load leveling, and for it, it is important to infiltrate the consciousness of energy saving into people. Users are not very interested in the information on power rates, would rather tend to seek comfortableness, and are less conscious of energy saving on days of unusual summer heat. Further, the power control in peal time zone was made by indicating users the actual state of power use by a combination of the two-way communication and the automatic meter reading system. However, at present, it cannot be denied that the power rate is higher even in indirect load control equipment with necessary/minimum conditions than the existing power source. It is a must to reduce the cost. The liberalization of electric power is progressing fast, and incentives for DSM are decreasing, but each of advanced countries is getting sensitive to the obedience to COP3. In addition to DSM such as the rebate program and financing program by the existing surcharge system, they are making efforts for development/promotion of new energy by creating the green electric power market. The load control technology is expected which does not disturb comfortableness and amenity of users. (NEDO)

Object-oriented user interfaces for personalized mobile learning

CERN Document Server

Alepis, Efthimios

2014-01-01

This book presents recent research in mobile learning and advanced user interfaces. It is shown how the combination of this fields can result in personalized educational software that meets the requirements of state-of-the-art mobile learning software. This book provides a framework that is capable of incorporating the software technologies, exploiting a wide range of their current advances and additionally investigating ways to go even further by providing potential solutions to future challenges. The presented approach uses the well-known Object-Oriented method in order to address these challenges. Throughout this book, a general model is constructed using Object-Oriented Architecture. Each chapter focuses on the construction of a specific part of this model, while in the conclusion these parts are unified. This book will help software engineers build more sophisticated personalized software that targets in mobile education, while at the same time retaining a high level of adaptivity and user-friendliness w...

Systems Biology of Metabolism: A Driver for Developing Personalized and Precision Medicine

DEFF Research Database (Denmark)

Nielsen, Jens

2017-01-01

for advancing the development of personalized and precision medicine to treat metabolic diseases like insulin resistance, obesity, NAFLD, NASH, and cancer. It will be illustrated how the concept of genome-scale metabolic models can be used for integrative analysis of big data with the objective of identifying...... novel biomarkers that are foundational for personalized and precision medicine....

Personal power systems

Energy Technology Data Exchange (ETDEWEB)

Dunn-Rankin, Derek; Leal, Elisangela Martins; Walther, David C. [Mechanical and Aerospace Engineering Department, University of California, Irvine, CA 92697 (United States)

2005-07-01

The lack of compact, efficient, human compatible, lightweight power sources impedes the realization of machine-enhanced human endeavor. Electronic and communication devices, as well as mobile robotic devices, need new power sources that will allow them to operate autonomously for periods of hours. In this work, a personal power system implies an application of interest to an individual person. The human-compatible gravimetric energy density spans the range from 500 to 5000Wh/kg, with gravimetric power density requirements from 10 to 1000W/kg. These requirements are the primary goals for the systems presented here. The review examines the interesting and promising concepts in electrochemical, thermochemical, and biochemical approaches to small-scale power, as well as their technological and physical challenges and limitations. Often it is the limitations that dominate, so that while the technology to create personal autonomy for communications, information processing and mobility has accelerated, similar breakthroughs for the systems powering these devices have not yet occurred. Fuel cells, model airplane engines, and hummingbird metabolism, are three promising examples, respectively, of electrochemical, thermochemical, and biochemical power production strategies that are close to achieving personal power systems' power demands. Fuel cells show great promise as an energy source when relatively low power density is demanded, but they cannot yet deliver high peak powers nor respond quickly to variable loads. Current small-scale engines, while achieving extraordinary power densities, are too inefficient to achieve the energy density needed for long-duration autonomous operation. Metabolic processes of flying insects and hummingbirds are remarkable biological energy converters, but duplicating, accelerating, and harnessing such power for mobility applications is virtually unexplored. These challenges are significant, and they provide a fertile environment for

Alarm personal dosemeter

International Nuclear Information System (INIS)

Nunomiya, Tomoya; Yamauchi, Hideshi; Shibata, Tetsuo

2007-01-01

Fuji Electric advanced the development of the conventional alarm personal dosemeter (APD) by adopting JIS Z 4312 (2002), which reflects IEC61526 (1998), and by improving the radiation performance characteristics, electromagnetic performance characteristics and mechanical performance characteristics of the APD (acquiring a CE marking). This new dosemeter will target overseas market in the future. The APD is a suitable dosemeter for detecting and monitoring radiation exposure to personnel working in the controlled areas of nuclear facilities, such as nuclear power stations. The APD product line includes 'gamma ray', 'gamma ray + beta ray' and 'gamma ray + neutron' models. (author)

Lumbopelvic muscle activation patterns in three stances under graded loading conditions: Proposing a tensegrity model for load transfer through the sacroiliac joints.

Science.gov (United States)

Pardehshenas, Hamed; Maroufi, Nader; Sanjari, Mohammad Ali; Parnianpour, Mohamad; Levin, Stephen M

2014-10-01

According to the conventional arch model of the pelvis, stability of the sacroiliac joints may require a predominance of form and force closure mechanisms: the greater the vertical shear force at the sacroiliac joints, the greater the reliance on self-bracing by horizontally or obliquely oriented muscles (such as the internal oblique). But what happens to the arch model when a person stands on one leg? In such cases, the pelvis no longer has imposts, leaving both the arch, and the arch model theory, without support. Do lumbopelvic muscle activation patterns in one-legged stances under load suggest compatibility with a different model? This study compares lumbopelvic muscle activation patterns in two-legged and one-legged stances in response to four levels of graded trunk loading in order to further our understanding the stabilization of the sacroiliac joints. Thirty male subjects experienced four levels of trunk loading (0%, 5%, 10% and 15% of body weight) by holding a bucket at one side, at three conditions: 1) two-legged standing with the bucket in the dominant hand, 2) ipsilateral loading: one-legged standing with the bucket in the dominant hand while using the same-side leg, and 3) contralateral loading: one-legged standing using the same leg used in condition 2, but with the bucket in the non-dominant hand. During these tasks, EMG signals from eight lumbopelvic muscles were collected. ANOVA with repeated design was performed on normalized EMG's to test the main effect of load and condition, and interaction effects of load by condition. Latissimus dorsi and erector spinae muscles showed an antagonistic pattern of activity toward the direction of load which may suggest these muscles as lateral trunk stabilizers. Internal oblique muscles showed a co-activation pattern with increasing task demand, which may function to increase lumbopelvic stability (P sacroiliac joint dysfunctions must be taken into consideration. Our hypothetical model may initiate thinking and

Performance of an optimally contact-cooled high-heat-load mirror at the APS

International Nuclear Information System (INIS)

Cai, Z.; Khounsary, A.; Lai, B.; McNulty, I.; Yun, W.

1998-01-01

X-ray undulator beamlines at third-generation synchrotrons facilities use either a monochromator or a mirror as the first optical element. In this paper, the thermal and optical performance of an optimally designed contact-cooled high-heat-load x-ray mirror used as the first optical element on the 2ID undulator beamline at the Advanced Photon Source (APS) is reported. It is shown that this simple and economical mirror design can comfortably handle the high heat load of undulator beamlines and provide good performance with long-term reliability and ease of operation. Availability and advantages of such mirrors can make the mirror-first approach to high-heat-load beamline design an attractive alternative to monochromator-first beamlines in many circumstances

Quantitative Analysis of Diverse Lactobacillus Species Present in Advanced Dental Caries

OpenAIRE

Byun, Roy; Nadkarni, Mangala A.; Chhour, Kim-Ly; Martin, F. Elizabeth; Jacques, Nicholas A.; Hunter, Neil

2004-01-01

Our previous analysis of 65 advanced dental caries lesions by traditional culture techniques indicated that lactobacilli were numerous in the advancing front of the progressive lesion. Production of organic acids by lactobacilli is considered to be important in causing decalcification of the dentinal matrix. The present study was undertaken to define more precisely the diversity of lactobacilli found in this environment and to quantify the major species and phylotypes relative to total load o...

Non-intrusive appliance load monitoring system based on a modern kWh-meter

Energy Technology Data Exchange (ETDEWEB)

Pihala, H. [VTT Energy, Espoo (Finland). Energy Systems

1998-12-01

Non-intrusive appliance load monitoring (NIALM) is a fairly new method to estimate load profiles of individual electric appliances in a small building, like a household, by monitoring the whole load at a single point with one recording device without sub-meters. Appliances have special electrical characteristics, the positive and negative active and reactive power changes during the time they are switched on or off. These changes are called events and are detected with a monitoring device called an event recorder. Different NIALM-concepts developed in Europe and in the United States are generally discussed. The NIALM-concept developed in this study is based on a 3-phase, power quality monitoring kWh-meter and unique load identification algorithms. This modern kWh-meter with a serial data bus to a laptop personal computer is used as die event recorder. The NIALM-concept of this presentation shows for the first time how a kWh-meter can be used at the same time for billing, power quality and appliance end-use monitoring. An essential part of the developed NIALM-system prototype is the software of load identification algorithms which runs in an off-line personal computer. These algorithms are able to identify, with a certain accuracy, both two-state and multi-state appliances. This prototype requires manual-setup in which the naming of appliances is performed. The results of the prototype NIALMS were verified in a large, single family detached house and they were compared to the results of other prototypes in France and the United States, although this comparison is difficult because of different supply systems, appliance stock and number of tested sites. Different applications of NIALM are discussed. Gathering of load research data, verification of DSM-programs, home automation, failure analysis of appliances and security surveillance of buildings are interesting areas of NIALM. Both utilities and customers can benefit from these applications. It is possible to

ALARA Principle Application for Loading Spent Nuclear Fuel Assemblies from Nuclear Research Reactor WR-S Mergal-Bucharest Romania into Transportation Casks

International Nuclear Information System (INIS)

Dragusin, M.

2009-01-01

Safety implementation of Spent Nuclear Fuels Assemblies (SNFA) handling procedures at the WR-S reactor site is ensured by technical perfection and reliability of equipment, monitoring of its condition, qualification and discipline of personnel as well as organization and execution of work complied with requirements of regulatory documents, process procedures, guidance and manuals. The personnel training for execution loading of SNF FAs is other important aspect for radiation protection and safely activities. Estimations carried out using Micro Shield software show that maximal dose rate upon working site when loading four FAs into basket of cask will not exceed 1.7 and 956;Sv/h, excluding natural radiation. Radiation Safety Analyses estimates for loading 70 SNFA in 18 transportation casks are: maximal individual dose: 4274.7 and 956;Sv, maximal expected collective dose persons: 17 031.2 man and 956;Sv. By application ALARA principle with technical and administrative measures the loading process developed in the following conditions: maximal individual dose: 68 and 956;Sv, the collective dose persons: 732 man and 956;Sv. The work will presented the technical measures and procedures applied in loading process.

Automatic fatigue monitoring based on real loads. Live demonstration

International Nuclear Information System (INIS)

Bergholz, Steffen; Rudolph, Juergen; Bruckmueller, Florian; Heinz, Benedikt; Jouan, Benoit

2012-01-01

The fatigue assessment of power plant components based on local fatigue monitoring approaches is an essential part of the integrity concept and modern lifetime management. An integral approach like the AREVA Fatigue Concept (AFC) basically consists of two essential modules: realistic determination of occurring operational thermal loads by means of a high end fatigue monitoring system and related highly qualified fatigue assessment methods and tools. The fatigue monitoring system delivers continuously realistic load data at the fatigue relevant locations. Consequently, realistic operational load sequences are available as input data for all ensuing fatigue analyses. This way, realistic load data are available and qualified fatigue usage factors can be determined. The mode of operation of the fatigue monitoring system will be explained in the framework of a live demonstration by means of the FAMOSi (i = integrated) demonstration wall. The workflow starts with the continuous online measurement of outer wall temperatures transients on a pipe. Visualization is implemented within the FAMOSi viewer software. In a second step, inner wall temperatures are directly calculated. In a third step, the resulting linearly elastic stress history will be calculated as the basis for subsequent code conforming fatigue assessment. Subsequently, the related advanced fatigue assessment methods of the three staged AFC-approach are addressed.

Porous media fracturing dynamics: stepwise crack advancement and fluid pressure oscillations

Science.gov (United States)

Cao, Toan D.; Hussain, Fazle; Schrefler, Bernhard A.

2018-02-01

We present new results explaining why fracturing in saturated porous media is not smooth and continuous but is a distinct stepwise process concomitant with fluid pressure oscillations. All exact solutions and almost all numerical models yield smooth fracture advancement and fluid pressure evolution, while recent experimental results, mainly from the oil industry, observation from geophysics and a very few numerical results for the quasi-static case indeed reveal the stepwise phenomenon. We summarize first these new experiments and these few numerical solutions for the quasi-static case. Both mechanical loading and pressure driven fractures are considered because their behaviours differ in the direction of the pressure jumps. Then we explore stepwise crack tip advancement and pressure fluctuations in dynamic fracturing with a hydro-mechanical model of porous media based on the Hybrid Mixture Theory. Full dynamic analyses of examples dealing with both hydraulic fracturing and mechanical loading are presented. The stepwise fracture advancement is confirmed in the dynamic setting as well as in the pressure fluctuations, but there are substantial differences in the frequency contents of the pressure waves in the two loading cases. Comparison between the quasi-static and fully dynamic solutions reveals that the dynamic response gives much more information such as the type of pressure oscillations and related frequencies and should be applied whenever there is a doubt about inertia forces playing a role - the case in most fracturing events. In the absence of direct relevant dynamic tests on saturated media some experimental results on dynamic fracture in dry materials, a fast hydraulic fracturing test and observations from geophysics confirm qualitatively the obtained results such as the type of pressure oscillations and the substantial difference in the behaviour under the two loading cases.

Advanced procedure for the assessments of the lifetime of solar absorber coatings

OpenAIRE

Köhl, M.; Heck, M.; Brunold, S.; Frei, U.; Carlsson, B.; Möller, K.

2003-01-01

New solar absorber coatings are developed and used in advanced collector designs with improved efficiency. The operation temperature as well as the stagnation temperature as the main durability load for the absorbers were increasing during the past due to these innovations. Especially the highly selective new coatings have to suffer by these stronger loads. The service life estimation procedure developed in the framework of research activities of the IEA Solar Heating and Cooling Programme (T...

Do Open Source LMSs Support Personalization? A Comparative Evaluation

Science.gov (United States)

Kerkiri, Tania; Paleologou, Angela-Maria

A number of parameters that support the LMSs capabilities towards content personalization are presented and substantiated. These parameters constitute critical criteria for an exhaustive investigation of the personalization capabilities of the most popular open source LMSs. Results are comparatively shown and commented upon, thus highlighting a course of conduct for the implementation of new personalization methodologies for these LMSs, aligned at their existing infrastructure, to maintain support of the numerous educational institutions entrusting major part of their curricula to them. Meanwhile, new capabilities arise as drawn from a more efficient description of the existing resources -especially when organized into widely available repositories- that lead to qualitatively advanced learner-oriented courses which would ideally meet the challenge of combining personification of demand and personalization of thematic content at once.

Advances in the analysis and design of concrete structures, metal containments and liner plate for extreme loads

International Nuclear Information System (INIS)

Stevenson, J.D.; Eibl, J.; Curbach, M.; Johnson, T.E.; Daye, M.A.; Riera, J.D.; Nemet, J.; Iyengar, K.T.S.

1992-01-01

The material presented in this paper summarizes the progress that has been made in the analysis, design, and testing of concrete structures. The material is summarized in the following documents: Part I: Containment Design Criteria and Loading Combinations; Part II: Reinforced and Prestressed Concrete Behavior; Part III: Concrete Containment Analysis, Design and Related Testing; Part IV: Impact and Impulse Loading and Response Prediction; Part V: Metal Containments and Liner Plate Systems; Part VI: Prestressed Reactor Vessel Design, Testing and Analysis. (orig.)

A person-centred approach in medicine to reduce the psychosocial and existential burden of chronic and life-threatening medical illness.

Science.gov (United States)

Grassi, Luigi; Mezzich, Juan E; Nanni, Maria Giulia; Riba, Michelle B; Sabato, Silvana; Caruso, Rosangela

2017-10-01

The psychiatric, psychosocial, and existential/spiritual pain determined by chronic medical disorders, especially if in advanced stages, have been repeatedly underlined. The right to approach patients as persons, rather than symptoms of organs to be repaired, has also been reported, from Paul Tournier to Karl Jaspers, in opposition and contrast with the technically-enhanced evidence-based domain of sciences that have reduced the patients to 'objects' and weakened the physician's identity deprived of its ethical value of meeting, listening, and treating subjects. The paper will discuss the main psychosocial and existential burden related to chronic and advanced medical illnesses, and the diagnostic and therapeutic implications for a dignity preserving care within a person-centred approach in medicine, examined in terms of care of the person (of the person's whole health), for the person (for the fulfilment of the person's health aspirations), by the person (with physicians extending themselves as total human beings), and with the person (working respectfully with the medically ill person).

Stress load during childhood affects psychopathology in psychiatric patients

Directory of Open Access Journals (Sweden)

Popov Tzvetan

2008-07-01

Full Text Available Abstract Background Childhood stress and trauma have been related to adult psychopathology in different psychiatric disorders. The present study aimed at verifying this relationship for stressful experiences during developmental periods by screening stress load across life in adult psychiatric inpatients with different diagnoses compared to healthy subjects. In addition, a relationship between the amount of adverse experiences and the severity of pathology, which has been described as a 'building block' effect in posttraumatic stress disorder (PTSD, was explored for non-traumatic events in psychiatric disorders other than PTSD. Methods 96 patients with diagnoses of Major Depressive Disorder (MDD, schizophrenia, drug addiction, or personality disorders (PD and 31 subjects without psychiatric diagnosis were screened for adverse experiences in childhood (before the age of six years, before onset of puberty, and in adulthood using the Early Trauma Inventory and the Posttraumatic Stress Diagnostic Scale. Effects of stress load on psychopathology were examined for affective symptoms, PTSD, and severity of illness by regression analyses and comparison of subgroups with high and low stress load. Results High stress load in childhood and before puberty, but not in adulthood, was related to negative affect in all participants. In patients, high stress load was related to depressive and posttraumatic symptoms, severity of disorder, and the diagnoses of MDD and PD. Conclusion Results support the hypothesis of stress-sensitive periods during development, which may interact with genetic and other vulnerability factors in their influence on the progress of psychiatric disorders. A 'dose' effect of stress load on the severity of psychopathology is not restricted to the relationship between traumata and PTSD.

Using remotely sensed imagery to estimate potential annual pollutant loads in river basins.

Science.gov (United States)

He, Bin; Oki, Kazuo; Wang, Yi; Oki, Taikan

2009-01-01

Land cover changes around river basins have caused serious environmental degradation in global surface water areas, in which the direct monitoring and numerical modeling is inherently difficult. Prediction of pollutant loads is therefore crucial to river environmental management under the impact of climate change and intensified human activities. This research analyzed the relationship between land cover types estimated from NOAA Advanced Very High Resolution Radiometer (AVHRR) imagery and the potential annual pollutant loads of river basins in Japan. Then an empirical approach, which estimates annual pollutant loads directly from satellite imagery and hydrological data, was investigated. Six water quality indicators were examined, including total nitrogen (TN), total phosphorus (TP), suspended sediment (SS), Biochemical Oxygen Demand (BOD), Chemical Oxygen Demand (COD), and Dissolved Oxygen (DO). The pollutant loads of TN, TP, SS, BOD, COD, and DO were then estimated for 30 river basins in Japan. Results show that the proposed simulation technique can be used to predict the pollutant loads of river basins in Japan. These results may be useful in establishing total maximum annual pollutant loads and developing best management strategies for surface water pollution at river basin scale.

Characteristics of personal health information management groups: findings from an online survey using Amazon's mTurk.

Science.gov (United States)

Kim, Sujin; Huber, Jeffrey T

2017-10-01

The study characterized three groups with different levels of familiarity with personal health information management (PHIM) in terms of their demographics, health knowledge, technological competency, and information sources and barriers. In addition, the authors examined differences among PHIM groups in subjective self-ratings and objective test scores for health literacy. A total of 202 survey participants were recruited using Amazon's Mechanical Turk (mTurk) service, a crowdsourcing Internet service. Using K-means clustering, three groups with differing levels of familiarity with PHIM were formed: Advanced, Intermediate, and Basic. The Advanced group was the youngest, and the Basic group contained the highest proportion of males, whereas the Intermediate group was the oldest and contained the fewest males. The Advanced group was significantly more likely to engage in provider- or hospital-initiated PHIM activities such as emailing with providers, viewing test results online, and receiving summaries of hospital visits via email or websites than the other groups. The Basic group had significantly lower information management skills and Internet use than the other groups. Advanced and Basic groups reported significant differences in several information barriers. While the Advanced group self-reported the highest general literacy, they scored lowest on an objective health literacy test. For effective personal health records management, it is critical to understand individual differences in PHIM using a comprehensive measure designed to assess personal health records-specific activities. Because they are trained to perform an array of information management activities, medical librarians or patient educators are well positioned to promote the effective use of personal health records by health consumers.

Sitting Posture Monitoring System Based on a Low-Cost Load Cell Using Machine Learning

Directory of Open Access Journals (Sweden)

Jongryun Roh

2018-01-01

Full Text Available Sitting posture monitoring systems (SPMSs help assess the posture of a seated person in real-time and improve sitting posture. To date, SPMS studies reported have required many sensors mounted on the backrest plate and seat plate of a chair. The present study, therefore, developed a system that measures a total of six sitting postures including the posture that applied a load to the backrest plate, with four load cells mounted only on the seat plate. Various machine learning algorithms were applied to the body weight ratio measured by the developed SPMS to identify the method that most accurately classified the actual sitting posture of the seated person. After classifying the sitting postures using several classifiers, average and maximum classification rates of 97.20% and 97.94%, respectively, were obtained from nine subjects with a support vector machine using the radial basis function kernel; the results obtained by this classifier showed a statistically significant difference from the results of multiple classifications using other classifiers. The proposed SPMS was able to classify six sitting postures including the posture with loading on the backrest and showed the possibility of classifying the sitting posture even though the number of sensors is reduced.

Advanced parallel processing with supercomputer architectures

International Nuclear Information System (INIS)

Hwang, K.

1987-01-01

This paper investigates advanced parallel processing techniques and innovative hardware/software architectures that can be applied to boost the performance of supercomputers. Critical issues on architectural choices, parallel languages, compiling techniques, resource management, concurrency control, programming environment, parallel algorithms, and performance enhancement methods are examined and the best answers are presented. The authors cover advanced processing techniques suitable for supercomputers, high-end mainframes, minisupers, and array processors. The coverage emphasizes vectorization, multitasking, multiprocessing, and distributed computing. In order to achieve these operation modes, parallel languages, smart compilers, synchronization mechanisms, load balancing methods, mapping parallel algorithms, operating system functions, application library, and multidiscipline interactions are investigated to ensure high performance. At the end, they assess the potentials of optical and neural technologies for developing future supercomputers

Students Perspectives toward Key Personal Finance Variables

Science.gov (United States)

Miller, Donald; Hite, Nancy Groneman; Slocombe, Tom; Railsback, Barbara

2010-01-01

Purpose: In the current economic climate, young people's attitudes and habits related to money management seem to be of great interest. The primary purpose of this study is to advance the knowledge base in the area of personal finance education. Methodology: This survey was administered by English teachers to a convenience sample population of 326…

HDAC inhibitor-loaded bone cement for advanced local treatment of osteosarcoma and chondrosarcoma.

Science.gov (United States)

Tonak, Marcus; Becker, Marc; Graf, Claudine; Eckhard, Lukas; Theobald, Matthias; Rommens, Pol-Maria; Wehler, Thomas C; Proschek, Dirk

2014-11-01

The treatment of osteosarcoma, especially wide resection, is challenging. An additional local drug therapy after resection using anti-neoplastic bone cement (Polymethylmethacrylate (PMMA)) could help improve the outcome of therapy. In this study, we evaluated the effects of PMMA loaded with valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA) on the cell activity of a SaOs-2 cell culture, as well as the elution rate of the drugs out of the bone cement. In our experiments, we used the SaOs-2 osteosarcoma and the SW1353 chondrosarcoma cell line. Bone cement clots (5 g) were prepared and loaded with different drug concentrations of VPA (25 mg and 50 mg) and SAHA (1 mg, 2.5 mg and 5 mg). Two control groups were established, one with a native cement clot, the other with human mesenchymal stem cells, in order to evaluate toxicity on non tumor-cells. Cell activity was measured using an Alamar Blue assay on days 1, 2, 3, 4 and 7. The cement clots were additionally examined in a material testing unit for biomechanical and structural changes. Tumor cells showed a significant and complete reduction of activity under therapy with VPA and SAHA. Drug release of VPA was extensive between days 0 and 3 and decreased progressively to day 7. Cumulative drug concentration in the medium continuously increased. Biomechanical testing of the cement clots showed no differences in stability and architecture compared to the control group. SaOs-2 and SW1353 cells with medium from native cement clots without drug therapy presented a cell activity of 100% in all groups and during all measurements. Human mesenchymal stem cells were not significantly affected during therapy with VPA and low concentrations of SAHA. In contrast, cell activity of human mesenchymal stem cells was significantly reduced under therapy with higher concentrations of SAHA, with an approximately linear decrease between days 0-3 and a rapidly decreasing activity between days 4-7. A local cytotoxic therapy in the

Combustion modeling in advanced gas turbine systems

Energy Technology Data Exchange (ETDEWEB)

Smoot, L.D.; Hedman, P.O.; Fletcher, T.H. [Brigham Young Univ., Provo, UT (United States)] [and others

1995-10-01

The goal of the U.S. Department of Energy`s Advanced Turbine Systems (ATS) program is to help develop and commercialize ultra-high efficiency, environmentally superior, and cost competitive gas turbine systems for base-load applications in the utility, independent power producer, and industrial markets. Combustion modeling, including emission characteristics, has been identified as a needed, high-priority technology by key professionals in the gas turbine industry.

Development of an advanced mobile base for personal mobility and manipulation appliance generation II robotic wheelchair.

Science.gov (United States)

Wang, Hongwu; Candiotti, Jorge; Shino, Motoki; Chung, Cheng-Shiu; Grindle, Garrett G; Ding, Dan; Cooper, Rory A

2013-07-01

This paper describes the development of a mobile base for the Personal Mobility and Manipulation Appliance Generation II (PerMMA Gen II robotic wheelchair), an obstacle-climbing wheelchair able to move in structured and unstructured environments, and to climb over curbs as high as 8 inches. The mechanical, electrical, and software systems of the mobile base are presented in detail, and similar devices such as the iBOT mobility system, TopChair, and 6X6 Explorer are described. The mobile base of PerMMA Gen II has two operating modes: "advanced driving mode" on flat and uneven terrain, and "automatic climbing mode" during stair climbing. The different operating modes are triggered either by local and dynamic conditions or by external commands from users. A step-climbing sequence, up to 0.2 m, is under development and to be evaluated via simulation. The mathematical model of the mobile base is introduced. A feedback and a feed-forward controller have been developed to maintain the posture of the passenger when driving over uneven surfaces or slopes. The effectiveness of the controller has been evaluated by simulation using the open dynamics engine tool. Future work for PerMMA Gen II mobile base is implementation of the simulation and control on a real system and evaluation of the system via further experimental tests.

Plastic limit loads for cylindrical shell intersections under combined loading

International Nuclear Information System (INIS)

Skopinsky, V.N.; Berkov, N.A.; Vogov, R.A.

2015-01-01

In this research, applied methods of nonlinear analysis and results of determining the plastic limit loads for shell intersection configurations under combined internal pressure, in-plane moment and out-plane moment loadings are presented. The numerical analysis of shell intersections is performed using the finite element method, geometrically nonlinear shell theory in quadratic approximation and plasticity theory. For determining the load parameter of proportional combined loading, the developed maximum criterion of rate of change of relative plastic work is employed. The graphical results for model of cylindrical shell intersection under different two-parameter combined loadings (as generalized plastic limit load curves) and three-parameter combined loading (as generalized plastic limit load surface) are presented on the assumption that the internal pressure, in-plane moment and out-plane moment loads were applied in a proportional manner. - Highlights: • This paper presents nonlinear two-dimensional FE analysis for shell intersections. • Determining the plastic limit loads under combined loading is considered. • Developed maximum criterion of rate of change of relative plastic work is employed. • Plastic deformation mechanism in shell intersections is discussed. • Results for generalized plastic limit load curves of branch intersection are presented

Energy management of a university campus utilizing short-term load forecasting with an artificial neural network

Science.gov (United States)

Palchak, David

Electrical load forecasting is a tool that has been utilized by distribution designers and operators as a means for resource planning and generation dispatch. The techniques employed in these predictions are proving useful in the growing market of consumer, or end-user, participation in electrical energy consumption. These predictions are based on exogenous variables, such as weather, and time variables, such as day of week and time of day as well as prior energy consumption patterns. The participation of the end-user is a cornerstone of the Smart Grid initiative presented in the Energy Independence and Security Act of 2007, and is being made possible by the emergence of enabling technologies such as advanced metering infrastructure. The optimal application of the data provided by an advanced metering infrastructure is the primary motivation for the work done in this thesis. The methodology for using this data in an energy management scheme that utilizes a short-term load forecast is presented. The objective of this research is to quantify opportunities for a range of energy management and operation cost savings of a university campus through the use of a forecasted daily electrical load profile. The proposed algorithm for short-term load forecasting is optimized for Colorado State University's main campus, and utilizes an artificial neural network that accepts weather and time variables as inputs. The performance of the predicted daily electrical load is evaluated using a number of error measurements that seek to quantify the best application of the forecast. The energy management presented utilizes historical electrical load data from the local service provider to optimize the time of day that electrical loads are being managed. Finally, the utilization of forecasts in the presented energy management scenario is evaluated based on cost and energy savings.

Engineering for high heat loads on ALS [Advanced Light Source] beamlines

International Nuclear Information System (INIS)

DiGennaro, R.; Swain, T.

1989-08-01

This paper discussed general thermal engineering problems and specific categories of thermal design issues for high photon flux beam lines at the LBL Advanced Light Source: thermal distortion of optical surfaces and elevated temperatures of thermal absorbers receiving synchrotron radiation. A generic design for water-cooled heat absorbers is described for use with ALS photon shutters, beam defining apertures, and heat absorbing masks. Also, results of in- situ measurements of thermal distortion of a water-cooled mirror in a synchrotron radiation beam line are compared with calculated performance estimates. 17 refs., 2 figs

Loads as a Resource: Frequency Responsive Demand

Energy Technology Data Exchange (ETDEWEB)

Kalsi, Karanjit [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hansen, Jacob [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fuller, Jason C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Marinovici, Laurentiu D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Elizondo, Marcelo A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Williams, Tess L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lian, Jianming [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sun, Yannan [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2015-12-01

Current power grid operation predominantly relies on scheduling and regulating generation resources to supply loads and balance load changes. Due to the inherent intermittency of renewable energy, more flexible and fast ramping capacity is required to compensate for the uncertainty and variability introduced by renewable energy resources. With the advancement of information technologies, power system end-use loads are becoming more agile and can participate in provision of balancing energy and other grid services. The use of demand response can greatly reduce the required generation reserve in a clean and environmentally friendly way. In this report, a new frequency responsive load (FRL) controller was proposed based on the GFA controller, which can respond to both over and under-frequency events. A supervisory control was introduced to coordinate the autonomous response from FRLs in order to overcome the issues of excessive system response due to high penetration of FRLs. The effectiveness of the proposed FRL controller was demonstrated by large-scale simulation studies on the WECC system. Specifically, the FRLs were deployed in the WECC system at different penetration levels to analyze the performance of the proposed strategy both with and without supervisory level control. While both methods have their own advantages, the case without supervisory control could lead to system-wide instability depending on the size of the contingency and the number of FRLs deployed in the system. In addition, the voltage impacts of this controller on distribution system were also carefully investigated. Finally, a preliminary measurement and verification approach was also developed.

[Psychopathy and associated personality disorders: searching for a particular effect of the borderline personality disorder?].

Science.gov (United States)

Nioche, A; Pham, T H; Ducro, C; de Beaurepaire, C; Chudzik, L; Courtois, R; Réveillère, C

2010-06-01

Recent clinical and empirical works are based on Cleckley's clinical observations in which psychopathy is viewed as a personality disorder, characterised by a lack of emotions, callousness, unreliability and superficiality. Hare operationalised Cleckley's concept of psychopathy by developing the Psychopathy Checklist-Revised composed of 20 items that load on two factors in majority: factor 1 (personality aspects of psychopathy) and factor 2 (behavioural manifestations), close to the antisocial personality disorder (DSM-IV criteria). Comorbidity is strong with antisocial personality disorder but also with histrionic, narcissistic and borderline disorders. As results of categorical studies relative to comorbidity suggest a strong comorbidity between psychopathy and other personality disorders, and particularly cluster B disorders (axis II, DSM-IV), this study assesses the relationships between psychopathy (dimensional approach) and personality disorders (categorical approach) and particularly with the borderline personality disorder. The aim of this study is also to underline the complementarity of categorical (SCID-II) and dimensional approaches (PCL-R), and the utility of the standardised clinical examination. We hypothesised positive associations between psychopathy and other personality disorders, mainly with the cluster B axis II (narcissistic, antisocial, histrionic, and borderline). Among those disorders, a particular link exists with the borderline personality disorder, considering that their association may attenuate the pathological level of the psychopathy. The sample included 80 male inmates from French prisons (age: M=31.48; SD=11.06). Each participant was evaluated with the PCL-R to assess the level of psychopathy and the SCID-II to assess the possible presence of personality disorders. The MINI and the WAIS-III were used to exclude respectively those who presented an axis I comorbidity (mood disorders and psychotic disorders established at the moment

Block models and personalized PageRank.

Science.gov (United States)

Kloumann, Isabel M; Ugander, Johan; Kleinberg, Jon

2017-01-03

Methods for ranking the importance of nodes in a network have a rich history in machine learning and across domains that analyze structured data. Recent work has evaluated these methods through the "seed set expansion problem": given a subset [Formula: see text] of nodes from a community of interest in an underlying graph, can we reliably identify the rest of the community? We start from the observation that the most widely used techniques for this problem, personalized PageRank and heat kernel methods, operate in the space of "landing probabilities" of a random walk rooted at the seed set, ranking nodes according to weighted sums of landing probabilities of different length walks. Both schemes, however, lack an a priori relationship to the seed set objective. In this work, we develop a principled framework for evaluating ranking methods by studying seed set expansion applied to the stochastic block model. We derive the optimal gradient for separating the landing probabilities of two classes in a stochastic block model and find, surprisingly, that under reasonable assumptions the gradient is asymptotically equivalent to personalized PageRank for a specific choice of the PageRank parameter [Formula: see text] that depends on the block model parameters. This connection provides a formal motivation for the success of personalized PageRank in seed set expansion and node ranking generally. We use this connection to propose more advanced techniques incorporating higher moments of landing probabilities; our advanced methods exhibit greatly improved performance, despite being simple linear classification rules, and are even competitive with belief propagation.

Mechanical effects associated with surface loading of dry rock due to glaciation

International Nuclear Information System (INIS)

Wahi, K.K.; Hunter, R.L.

1985-01-01

Many scenarios of interest for a repository in the Pasco Basin begin with glaciation. Loading and unloading of joints and fractures due to the weight of ice sheets could affect the hydrologic properties of the host rock and surrounding units. Scoping calculations performed using two-dimensional numerical models with simplifying assumptions predict stress changes and uplift or subsidence caused by an advancing glacier. The magnitudes of surface uplift and subsidence predicted by the study agree well with previous independent predictions. Peak stress unloading near the repository horizon is a small fraction of the ambient stress. Any resultant aperture increase is likewise small. Based on the results of this study, mechanical loading caused by a glacier is expected to have a minimal effect on rock permeability, assuming that the excess compressive loads do not crush the rock. 13 refs., 3 figs., 1 tab

Scoping Report: Advanced Technologies for Multi-Load Washers in Hospitality and Healthcare

Energy Technology Data Exchange (ETDEWEB)

Parker, Graham B.; Boyd, Brian K.; Petersen, Joseph M.; Goetzler, W.; Foley, K. J.; Sutherland, T. A.

2013-03-27

The purpose of this demonstration project is to quantify the energy savings and water efficiency potential of commercial laundry wastewater recycling systems and low-temperature detergent supply systems to help promote the adoption of these technologies in the commercial sector. This project will create a set of technical specifications for efficient multi-load laundry systems (both new and retrofit) tailored for specific applications and/or sectors (e.g., hospitality, health care). The specifications will be vetted with the appropriate Better Buildings Alliance (BBA) members (e.g., Commercial Real Estate Energy Alliance, Hospital Energy Alliance), finalized, published, and disseminated to enable widespread technology transfer in the industry and specifically among BBA partners.

Opposite effects of capacity load and resolution load on distractor processing.

Science.gov (United States)

Zhang, Weiwei; Luck, Steven J

2015-02-01

According to the load theory of attention, an increased perceptual load reduces distractor processing whereas an increased working memory load facilitates distractor processing. Here we raise the possibility that the critical distinction may instead be between an emphasis on resolution and an emphasis on capacity. That is, perceptual load manipulations typically emphasize resolution (fine-grained discriminations), whereas working memory load manipulations typically emphasize capacity (simultaneous processing of multiple relevant stimuli). To test the plausibility of this hypothesis, we used a visual working memory task that emphasized either the number of items to be stored (capacity load, retaining 2 vs. 4 colors) or the precision of the representations (resolution load, detecting small vs. large color changes). We found that an increased capacity load led to increased flanker interference (a measure of distractor processing), whereas an increased resolution load led to reduced flanker interference. These opposite effects of capacity load and resolution load on distractor processing mirror the previously described opposite effects of perceptual load and working memory load.

In Respect to the Cognitive Load Theory: Adjusting Instructional Guidance with Student Expertise.

Science.gov (United States)

Schilling, Jim

2017-01-01

The amount of guidance supplied by educators to students in allied health programs is a factor in student learning. According to the cognitive load theory of learning, without adequate instructional support, novice learners will be overwhelmed and unable to store information, while unnecessary guidance supplied to advanced students will cause extraneous cognitive load on the working memory system. Adjusting instructional guidance for students according to their level of expertise to minimize extraneous cognitive load and optimize working memory storage capacity will enhance learning effectiveness. Novice students presented with complex subject matter require significant guidance during the initial stages, using strategies such as worked examples. As students comprehend information, instructional guidance needs to gradually fade to avoid elevated extraneous cognitive load from the expertise reversal effect. An instructional strategy that utilizes a systemic (fixed) or adjustable (adaptive) tapering of guidance to students in allied health programs depending on their expertise will optimize learning capability.

Thermal load forecasting in district heating networks using deep learning and advanced feature selection methods

NARCIS (Netherlands)

Suryanarayana, Gowri; Lago Garcia, J.; Geysen, Davy; Aleksiejuk, Piotr; Johansson, Christian

2018-01-01

Recent research has seen several forecasting methods being applied for heat load forecasting of district heating networks. This paper presents two methods that gain significant improvements compared to the previous works. First, an automated way of handling non-linear dependencies in linear

Exploratory structural equation modeling of personality data.

Science.gov (United States)

Booth, Tom; Hughes, David J

2014-06-01

The current article compares the use of exploratory structural equation modeling (ESEM) as an alternative to confirmatory factor analytic (CFA) models in personality research. We compare model fit, factor distinctiveness, and criterion associations of factors derived from ESEM and CFA models. In Sample 1 (n = 336) participants completed the NEO-FFI, the Trait Emotional Intelligence Questionnaire-Short Form, and the Creative Domains Questionnaire. In Sample 2 (n = 425) participants completed the Big Five Inventory and the depression and anxiety scales of the General Health Questionnaire. ESEM models provided better fit than CFA models, but ESEM solutions did not uniformly meet cutoff criteria for model fit. Factor scores derived from ESEM and CFA models correlated highly (.91 to .99), suggesting the additional factor loadings within the ESEM model add little in defining latent factor content. Lastly, criterion associations of each personality factor in CFA and ESEM models were near identical in both inventories. We provide an example of how ESEM and CFA might be used together in improving personality assessment. © The Author(s) 2014.

Effect of advanced injection timing on the performance of rapeseed oil in diesel engines

International Nuclear Information System (INIS)

Nwafor, O.M.I.; Rice, G.; Ogbonna, A.I.

2000-01-01

Combustion studies on both diesel fuel and vegetable oil fuels, with the standard and advanced injection timing, were carried out using the same engine and test procedures so that comparative assessments may be made. The diesel engine principle demands self-ignition of the fuel as it is injected at some degrees before top dead centre (BTDC) into the hot compressed cylinder gas. Longer delays between injection and ignition lead to unacceptable rates of pressure rise with the result of diesel knock because too much fuel is ready to take part in premixed combustion. Alternative fuels have been noted to exhibit longer delay periods and slower burning rate especially at low load operating conditions hence resulting in late combustion in the expansion stroke. Advanced injection timing is expected to compensate these effects. The engine has standard injection timing of 30degC BTDC. The injection was first advanced by 5.5degC given injection timing of 35.5degC BTDC. The engine performance was very erratic on this timing. The injection was then advanced by 3.5degC and the effects are presented in this paper. The engine performance was smooth especially at low load levels. The ignition delay was reduced through advanced injection but tended to incur a slight increase in fuel consumption. Moderate advanced injection timing is recommended for low speed operations. (Author)

Load testing circuit

DEFF Research Database (Denmark)

2009-01-01

A load testing circuit a circuit tests the load impedance of a load connected to an amplifier. The load impedance includes a first terminal and a second terminal, the load testing circuit comprising a signal generator providing a test signal of a defined bandwidth to the first terminal of the load...

Transient beam loading in the ALS harmonic RF system

International Nuclear Information System (INIS)

Byrd, J.; De Santis, S.; Georgsson, M.; Stover, G.; Fox, J.; Prabhakar, S.; Teytelman, D.

2000-01-01

We report on the commissioning of a higher harmonic radiofrequency system at the Advanced Light Source, designed to improve the beam lifetime. We have achieved an increase above a factor of two in our best results up to now. Transient beam loading of the harmonic cavities, due to the unequal fill patterns, creates the greatest limitation on lifetime improvement. We also describe several interesting effects on the operation of the longitudinal and transverse multibunch feedback system

Innovation in the personal care industry.

Science.gov (United States)

Knaggs, Helen

2010-09-01

When considering opportunities to develop novel, eye-catching and consumer-relevant personal care (PC) products, it is important to understand and reflect on how science has changed over the last two decades and how this has generated a new body of data from which to draw ideas and technologies. This article outlines some advances in scientific technologies and new ways of thinking in science, which lead to new insights into skin biology. How these innovations may impact and be leveraged into the development of new products in PC is also discussed. For example, fundamental discoveries in skin biology and the advancement of scientific methodologies are enabling step changes in technology in PC. Two examples of areas where we have seen much advancement are discussed. This article is based on and summarizes a presentation given at the HBA in Sep 2009 as part of a session entitled "Emerging Technologies and New Opportunities in Antiaging in PC." © 2010 Wiley Periodicals, Inc.

[Voting by cognitively impaired persons: legal and ethical issues].

Science.gov (United States)

Bosquet, Antoine; Medjkane, Amar; Vinceneux, Philippe; Mahé, Isabelle

2010-03-01

In democratic countries, cognitively impaired persons are a substantial and growing group of citizens. Most of them are citizens with dementia. In dementia, cognitive impairment induces a loss of some capacities, resulting in vulnerability and increased need for assistance. Voting by cognitively impaired persons raises any questions about the integrity of the electoral process, the risk of fraud and the respect of their citizenship. In France, the law is not definite about the voting of cognitively impaired persons. An objective assessment for voting capacity may be useful both for professionals in charge of voting organisation and for guardianship judge in order to help him in his decision to remove or keep the voting right of persons placed under guardianship. Assessing the reality of voting by cognitively impaired citizens is necessary to advance respect for their right to vote.

46 CFR 154.1730 - Ethylene oxide: Loading and off loading.

Science.gov (United States)

2010-10-01

... 46 Shipping 5 2010-10-01 2010-10-01 false Ethylene oxide: Loading and off loading. 154.1730... Operating Requirements § 154.1730 Ethylene oxide: Loading and off loading. (a) The master shall ensure that before ethylene oxide is loaded into a cargo tank: (1) The tank is thoroughly clean, dry, and free of...

Additional helmet and pack loading reduce situational awareness during the establishment of marksmanship posture.

Science.gov (United States)

Lim, Jongil; Palmer, Christopher J; Busa, Michael A; Amado, Avelino; Rosado, Luis D; Ducharme, Scott W; Simon, Darnell; Van Emmerik, Richard E A

2017-06-01

The pickup of visual information is critical for controlling movement and maintaining situational awareness in dangerous situations. Altered coordination while wearing protective equipment may impact the likelihood of injury or death. This investigation examined the consequences of load magnitude and distribution on situational awareness, segmental coordination and head gaze in several protective equipment ensembles. Twelve soldiers stepped down onto force plates and were instructed to quickly and accurately identify visual information while establishing marksmanship posture in protective equipment. Time to discriminate visual information was extended when additional pack and helmet loads were added, with the small increase in helmet load having the largest effect. Greater head-leading and in-phase trunk-head coordination were found with lighter pack loads, while trunk-leading coordination increased and head gaze dynamics were more disrupted in heavier pack loads. Additional armour load in the vest had no consequences for Time to discriminate, coordination or head dynamics. This suggests that the addition of head borne load be carefully considered when integrating new technology and that up-armouring does not necessarily have negative consequences for marksmanship performance. Practitioner Summary: Understanding the trade-space between protection and reductions in task performance continue to challenge those developing personal protective equipment. These methods provide an approach that can help optimise equipment design and loading techniques by quantifying changes in task performance and the emergent coordination dynamics that underlie that performance.

Structural Loads Analysis for Wave Energy Converters: Preprint

Energy Technology Data Exchange (ETDEWEB)

van Rij, Jennifer A [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Yu, Yi-Hsiang [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Guo, Yi [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

2017-08-09

This study explores and verifies the generalized body-modes method for evaluating the structural loads on a wave energy converter (WEC). Historically, WEC design methodologies have focused primarily on accurately evaluating hydrodynamic loads, while methodologies for evaluating structural loads have yet to be fully considered and incorporated into the WEC design process. As wave energy technologies continue to advance, however, it has become increasingly evident that an accurate evaluation of the structural loads will enable an optimized structural design, as well as the potential utilization of composites and flexible materials, and hence reduce WEC costs. Although there are many computational fluid dynamics, structural analyses and fluid-structure-interaction (FSI) codes available, the application of these codes is typically too computationally intensive to be practical in the early stages of the WEC design process. The generalized body-modes method, however, is a reduced order, linearized, frequency-domain FSI approach, performed in conjunction with the linear hydrodynamic analysis, with computation times that could realistically be incorporated into the WEC design process. The objective of this study is to verify the generalized body-modes approach in comparison to high-fidelity FSI simulations to accurately predict structural deflections and stress loads in a WEC. Two verification cases are considered, a free-floating barge and a fixed-bottom column. Details for both the generalized body-modes models and FSI models are first provided. Results for each of the models are then compared and discussed. Finally, based on the verification results obtained, future plans for incorporating the generalized body-modes method into the WEC simulation tool, WEC-Sim, and the overall WEC design process are discussed.

Augmented reality for personalized nanomedicines.

Science.gov (United States)

Lee, Yugyung; Lee, Chi H

As our understanding of onset and progress of diseases at the genetic and molecular level rapidly progresses, the potential of advanced technologies, such as 3D-printing, Socially-Assistive Robots (SARs) or augmented reality (AR), that are applied to personalized nanomedicines (PNMs) to alleviate pathological conditions, has become more prominent. Among advanced technologies, AR in particular has the greatest potential to address those challenges and facilitate the translation of PNMs into formidable clinical application of personalized therapy. As AR is about to adapt additional new methods, such as speech, voice recognition, eye tracing and motion tracking, to enable interaction with host response or biological systems in 3-D space, a combination of multiple approaches to accommodate varying environmental conditions, such as public noise and atmosphere brightness, will be explored to improve its therapeutic outcomes in clinical applications. For instance, AR glasses still being developed by Facebook or Microsoft will serve as new platform that can provide people with the health information they are interested in or various measures through which they can interact with medical services. This review has addressed the current progress and impact of AR on PNMs and its application to the biomedical field. Special emphasis is placed on the application of AR based PNMs to the treatment strategies against senior care, drug addiction and medication adherence. Published by Elsevier Inc.

Investigation on the Performance of UPQC-Q for Voltage Sag Mitigation and PQ Improvement at a Critical Load Point

OpenAIRE

Basu, Malabika; Das, S. P.; Dubey, Gopal

2008-01-01

The unified power quality conditioner (UPQC) is one of the major custom power solutions, which is capable of mitigating the effect of supply voltage sag at the load end or at the point of common coupling (PCC) in a distributed network. It also prevents the propagation of the load current harmonics to the utility and improves the input power factor of the load. The control of series compensator (SERC) of the UPQC is such that it injects voltage in quadrature advance to the supply current. Thus...

11 CFR 100.52 - Gift, subscription, loan, advance or deposit of money.

Science.gov (United States)

2010-01-01

... money. 100.52 Section 100.52 Federal Elections FEDERAL ELECTION COMMISSION GENERAL SCOPE AND DEFINITIONS..., advance or deposit of money. (a) A gift, subscription, loan (except for a loan made in accordance with 11 CFR 100.72 and 100.73), advance, or deposit of money or anything of value made by any person for the...

Peak load-impulse characterization of critical pulse loads in structural dynamics

International Nuclear Information System (INIS)

Abrahamson, G.R.; Lindberg, H.E.

1975-01-01

In presenting the characterization scheme, some general features are described first. A detailed analysis is given for the rigid-plastic system of one degree of freedom to illustrate the calculation of critical load curves in terms of peak load and impulse. This is followed by the presentation of critical load curves for uniformly loaded rigid-plastic beams and plates and for dynamic buckling of cylindrical shells under uniform lateral loads. The peak load-impulse characterization of critical pulse loads is compared with the dynamic load factor characterization, and some aspects of the history of the peak load-pulse scheme are presented. (orig./HP) [de

Advances in fingerprint analysis.

Science.gov (United States)

Hazarika, Pompi; Russell, David A

2012-04-10

Fingerprints have been used in forensic investigations for the identification of individuals since the late 19th century. However, it is now clear that fingerprints can provide significantly more information about an individual. Here, we highlight the considerable advances in fingerprinting technology that can simultaneously provide chemical information regarding the drugs ingested and the explosives and drugs handled by a person as well as the identity of that individual. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Level best : drilling seasonal load leveling business case : final report

International Nuclear Information System (INIS)

2005-10-01

Drilling and seismic costs in Western Canada are as much as 35 per cent higher during winter months. Favourable commodity pricing has prompted aggressive expansion of drilling programs in the Western Canada Sedimentary Basin (WCSB), and capacity is becoming a significant issue. Many operators are turning to load leveling in order to secure rigs and crew availability. However, many operators still adhere to the traditional view that drilling of oil and gas wells is best accomplished during the winter. The purpose of the project discussed in this paper was to develop and present a business case for greater seasonal load leveling in the WCSB and spreading it more evenly throughout the year. Using calendar year quarters, publicly available data for a 5 year period from 2000-2004 for drilling activity, safety, weather, and environmental restrictions were examined. A list of candidate fields with high levels of activity and a good representation of well depths was selected. Well cost and rig data from 14 different companies was used. A variety of industry participants, drilling contractors, load leveling technology suppliers and provincial agencies were consulted to supplement well cost analyses. The financial impacts of load leveling were examined. Benefits included lower well costs; advanced production; avoided rig construction; reduced incident rates; and reduced turnover. While the focus of the business case for load leveling was based on hard cost data, many indirect benefits were identified, including First Nations sustainability and greater job security and comfort for workers. Various policies and incentives that encouraged load leveling in British Columbia and Alberta were reviewed. 57 figs

Information security risk measures for cloud-based personal health records

CSIR Research Space (South Africa)

Mxoli, A

2014-11-01

Full Text Available Personal Health Records (PHRs) provide a convenient way for individuals to better manage their health. With the advancement in technology, they can be stored via Cloud Computing. These are pay-per-use applications offered as a service over...

Advances in geochemistry during the last four decades: A personal perspective

International Nuclear Information System (INIS)

Galimov, Eric M.

2009-01-01

This is the author's speech at the meeting in Cologne (2007) to celebrate the 40th anniversary of the International Association of Geochemistry and Cosmochemistry, which the author served as the President in 2000 to 2004. The paper narrates the author's personal involvement in important scientific programs during the last 4 decades, including implementation of isotope techniques, oil-and-gas research, diamond research, deep-sea drilling, space research, molecular biology and the origin of life.

Singing in individual music therapy with elderly persons suffering from dementia

DEFF Research Database (Denmark)

Ridder, Hanne Mette Ochsner

2001-01-01

The focus of this research in progress is my clinical work with persons suffering from dementia, where we sing long familiar songs in the music therapy. In an exploratory case study approach I have made systematic observations of 6 individual residents living in a gerontopsychological unit. My...... hypotheses are …  … that singing has an influence on persons with dementia, and that this influence can be defined upon communicative characteristics.  … that persons with dementia in an advanced stage communicate musically, and that this musical communication can be recognised by a system of communicative...

Advanced transport systems analysis, modeling, and evaluation of performances

CERN Document Server

Janić, Milan

2014-01-01

This book provides a systematic analysis, modeling and evaluation of the performance of advanced transport systems. It offers an innovative approach by presenting a multidimensional examination of the performance of advanced transport systems and transport modes, useful for both theoretical and practical purposes. Advanced transport systems for the twenty-first century are characterized by the superiority of one or several of their infrastructural, technical/technological, operational, economic, environmental, social, and policy performances as compared to their conventional counterparts. The advanced transport systems considered include: Bus Rapid Transit (BRT) and Personal Rapid Transit (PRT) systems in urban area(s), electric and fuel cell passenger cars, high speed tilting trains, High Speed Rail (HSR), Trans Rapid Maglev (TRM), Evacuated Tube Transport system (ETT), advanced commercial subsonic and Supersonic Transport Aircraft (STA), conventionally- and Liquid Hydrogen (LH2)-fuelled commercial air trans...

Evaluation of ADVANCE: A Nontraditional Adult Diploma Program.

Science.gov (United States)

Deegan, James

An evaluation of Project ADVANCE (Adult Diploma Validating and Accrediting Necessary Competence and Experiences), an adult competency-based high school completion program, was conducted to determine program effectiveness, as viewed subjectively by recent graduates and present students. Personal interviews and/or questionnaires were given to 31 of…

In-situ investigations of structural changes during cyclic loading by high resolution reciprocal space mapping

DEFF Research Database (Denmark)

Diederichs, Annika M.; Thiel, Felix; Lienert, Ulrich

2017-01-01

dislocation structures can be identified using advanced electron microscopy and synchrotron techniques. A detailed characterization of the microstructure during cyclic loading by in-situ monitoring the internal structure within individual grains with high energy x-rays can help to understand and predict...... the materials behavior during cyclic deformation and to improve the material design. While monitoring macroscopic stress and strain during cyclic loading, reciprocal space maps of diffraction peaks from single grains are obtained with high resolution. High Resolution Reciprocal Space Mapping was applied...

System and method employing a minimum distance and a load feature database to identify electric load types of different electric loads

Science.gov (United States)

Lu, Bin; Yang, Yi; Sharma, Santosh K; Zambare, Prachi; Madane, Mayura A

2014-12-23

A method identifies electric load types of a plurality of different electric loads. The method includes providing a load feature database of a plurality of different electric load types, each of the different electric load types including a first load feature vector having at least four different load features; sensing a voltage signal and a current signal for each of the different electric loads; determining a second load feature vector comprising at least four different load features from the sensed voltage signal and the sensed current signal for a corresponding one of the different electric loads; and identifying by a processor one of the different electric load types by determining a minimum distance of the second load feature vector to the first load feature vector of the different electric load types of the load feature database.

A novel monochromator for high heat-load synchrotron x-ray radiation

International Nuclear Information System (INIS)

Khounsary, A.M.

1992-01-01

The high heat load associated with the powerful and concentrated x-ray beams generated by the insertion devices at a number of present and many of the future (planned or under construction) synchrotron radiation facilities pose a formidable engineering challenge in the designer of the monochromators and other optical devices. For example, the Undulator A source on the Advanced Photon Source (APS) ring (being constructed at the Argonne National Laboratory) will generate as much as 10 kW of heat deposited on a small area (about 1 cm 2 ) of the first optics located some 24 m from the source. The peak normal incident heat flux can be as high as 500 W/mm 2 . Successful utilization of the intense x-ray beams from insertion devices critically depends on the development, design, and availability of optical elements that provide acceptable performance under high heat load. Present monochromators can handle, at best, heat load levels that are an order of magnitude lower than those generated by such sources. The monochromator described here and referred to as the open-quote inclinedclose quotes monochromator can provide a solution to high heat-load problems

The Personal Development Plan Practice Questionnaire: The Development and Validation of an Instrument to Assess the Employee's Perception of Personal Development Plan Practice

Science.gov (United States)

Beausaert, Simon; Segers, Mien; Gijselaers, Wim

2011-01-01

Confronted with the speed of technological advancements and increasing global competition, organizations have come to realize that their employees' continuous learning drives business success. A popular tool to support and enhance continuous learning is the personal development plan (PDP). Despite its popularity, empirical evidence of the…

Development of Personalized Cancer Therapy for Men with Advanced Prostate Cancer

Science.gov (United States)

2017-10-01

of this study is to develop a strategy to identify molecular markers of response of advanced prostate cancer to specific therapies using clinically...combination treatment strategies are urgently needed. The purpose of this study is to develop a strategy for identifying molecular markers of response of...PENDING) Level of Funding: $125,978 annual direct Project Goals: To develop a strategy for identifying molecular therapeutic response markers of

System and method employing a self-organizing map load feature database to identify electric load types of different electric loads

Science.gov (United States)

Lu, Bin; Harley, Ronald G.; Du, Liang; Yang, Yi; Sharma, Santosh K.; Zambare, Prachi; Madane, Mayura A.

2014-06-17

A method identifies electric load types of a plurality of different electric loads. The method includes providing a self-organizing map load feature database of a plurality of different electric load types and a plurality of neurons, each of the load types corresponding to a number of the neurons; employing a weight vector for each of the neurons; sensing a voltage signal and a current signal for each of the loads; determining a load feature vector including at least four different load features from the sensed voltage signal and the sensed current signal for a corresponding one of the loads; and identifying by a processor one of the load types by relating the load feature vector to the neurons of the database by identifying the weight vector of one of the neurons corresponding to the one of the load types that is a minimal distance to the load feature vector.

Drift scale thermomechanical analysis for thermal loading and retrievability studies

International Nuclear Information System (INIS)

Tsai, F.C.

1995-01-01

The repository portion of the Mined Geologic Disposal System for the disposal of spent nuclear fuel and high-level radioactive waste is currently in the advanced conceptual design stage. In support of systems studies, a numerical method was used to estimate the stability of emplacement drifts. Thermomechanical analyses, using the Discontinuous Deformation Analysis code, were performed using input data from Yucca Mountain documents. The analysis found that the stresses produced in the rock at thermal loads of 27.4 kilograms uranium per m2 (KgU/m2) would exceed stability criteria and could result in tunnel instability. At thermal loads between 20.5 KgU/m2, the drift is predicted to be stable and its structural integrity remains after thermal loading. In this case, the smaller diameter drift emplacement appears to have better stability. However, local rock spalling may occur. According to the numerical prediction, more rock fall may occur during the retrieval period due to the stress relaxation caused by the rapid cooling in the immediate drift area

Advances in research of targeting delivery and controlled release of drug-loaded nanoparticles

International Nuclear Information System (INIS)

Tan Zhonghua

2003-01-01

Biochemistry drug, at present, is still the main tool that human struggle to defeat the diseases. So, developing safe and efficacious technique of drug targeting delivery and controlled release is key to enhance curative effect, decrease drug dosage, and lessen its side effect. Drug-loaded nanoparticles, which is formed by conjugate between nanotechnology and modern pharmaceutics, is a new fashioned pharmic delivery carrier. Because of advantages in pharmic targeting transport and controlled or slow release and improving bioavailability, it has been one of developing trend of modern pharmaceutical dosage forms

Climate Control Load Reduction Strategies for Electric Drive Vehicles in Warm Weather

Energy Technology Data Exchange (ETDEWEB)

Jeffers, M. A.; Chaney, L.; Rugh, J. P.

2015-04-30

Passenger compartment climate control is one of the largest auxiliary loads on a vehicle. Like conventional vehicles, electric vehicles (EVs) require climate control to maintain occupant comfort and safety, but cabin heating and air conditioning have a negative impact on driving range for all electric vehicles. Range reduction caused by climate control and other factors is a barrier to widespread adoption of EVs. Reducing the thermal loads on the climate control system will extend driving range, thereby reducing consumer range anxiety and increasing the market penetration of EVs. Researchers at the National Renewable Energy Laboratory have investigated strategies for vehicle climate control load reduction, with special attention toward EVs. Outdoor vehicle thermal testing was conducted on two 2012 Ford Focus Electric vehicles to evaluate thermal management strategies for warm weather, including solar load reduction and cabin pre-ventilation. An advanced thermal test manikin was used to assess a zonal approach to climate control. In addition, vehicle thermal analysis was used to support testing by exploring thermal load reduction strategies, evaluating occupant thermal comfort, and calculating EV range impacts. Through stationary cooling tests and vehicle simulations, a zonal cooling configuration demonstrated range improvement of 6%-15%, depending on the drive cycle. A combined cooling configuration that incorporated thermal load reduction and zonal cooling strategies showed up to 33% improvement in EV range.

Advance directives as autonomy enhancers: reality or myth?

OpenAIRE

Navarro Michel, Mónica

2015-01-01

In the last few decades there has been a wealth of literature and legislation on advance directives. As you all know, it is an instrument by which a person can express their wishes as regards what treatment they should be given or, more to the point, not to be given, when he is in a situation when he can not do so himself. Regulations in the western world seem to promote advance directives as a way to enhance patient¿s autonomy in the context of human rights, and the media has presen...

Demand Response Load Following of Source and Load Systems

DEFF Research Database (Denmark)

Hu, Jianqiang; Cao, Jinde; Yong, Taiyou

2017-01-01

This paper presents a demand response load following strategy for an interconnected source and load system, in which we utilize traditional units and population of cooling thermostatically controlled loads (TCLs) to follow the mismatched power caused by the load activities and the renewable power...... injection in real time. In the demand side of power systems, these TCLs are often affiliated to a bus load agent and can be aggregated to multiple TCL aggregators. Firstly, aggregate evaluation of the TCL aggregator is carried out based on a bilinear aggregate model so as to derive the available regulation...

Cognitive Load Theory: How Many Types of Load Does It Really Need?

Science.gov (United States)

Kalyuga, Slava

2011-01-01

Cognitive load theory has been traditionally described as involving three separate and additive types of load. Germane load is considered as a learning-relevant load complementing extraneous and intrinsic load. This article argues that, in its traditional treatment, germane load is essentially indistinguishable from intrinsic load, and therefore…

End user programming with personally meaningful objects

CSIR Research Space (South Africa)

Smith, Andrew C

2016-09-01

Full Text Available (Kimchi et al., 2003). Perceptual organisation is a neuro-cognitive process that dictates how we perceive objects in physical space and how we interpret some objects as being distinct from others and yet other objects as part of a whole (Helm, 2014... called the designer-cum-user. Using this approach, the user creates a personally meaningful artefact that represents the target product. Although not confirmed, we anticipate that this approach reduces the initial cognitive load on the user when he uses...

Dimensions of personality structure among patients with substance use disorders and co-occurring personality disorders: a comparison with psychiatric outpatients and healthy controls.

Science.gov (United States)

Di Pierro, Rossella; Preti, Emanuele; Vurro, Nicoletta; Madeddu, Fabio

2014-08-01

Although dual diagnosis has been a topic of great scientific interest for a long time, few studies have investigated the personality traits that characterize patients suffering from substance use disorders and co-occurring personality disorders through a dimensional approach. The present study aimed to evaluate structural personality profiles among dual-diagnosis inpatients to identify specific personality impairments associated with dual diagnosis. The present study involved 97 participants divided into three groups: 37 dual-diagnosis inpatients, 30 psychiatric outpatients and 30 nonclinical controls. Dimensions of personality functioning were assessed and differences between groups were tested using Kernberg's dimensional model of personality. Results showed that dual diagnosis was associated with the presence of difficulties in three main dimensions of personality functioning. Dual-diagnosis inpatients reported a poorly integrated identity with difficulties in the capacity to invest, poorly integrated moral values, and high levels of self-direct and other-direct aggression. The present study highlighted that a dimensional approach to the study of dual diagnosis may clarify the personality functioning of patients suffering from this pathological condition. The use of the dimensional approach could help to advance research on dual diagnosis, and it could have important implications on clinical treatment programs for dual-diagnosis inpatients. Copyright © 2014 Elsevier Inc. All rights reserved.

Analyzing Design Heating Loads in Superinsulated Buildings

Energy Technology Data Exchange (ETDEWEB)

Arena, Lois [Consortium for Advanced Residential Buildings, Norwalk, CT (United States)

2015-06-16

The U.S. Department of Energy’s Building America research team Consortium for Advanced Residential Buildings (CARB) worked with the EcoVillage cohousing community in Ithaca, New York, on the Third Residential EcoVillage Experience neighborhood. This communityscale project consists of 40 housing units—15 apartments and 25 single-family residences. Units range in size from 450 ft2 to 1,664 ft2 and cost from $80,000 for a studio apartment to $235,000 for a three- or four-bedroom single-family home. For the research component of this project, CARB analyzed current heating system sizing methods for superinsulated homes in cold climates to determine if changes in building load calculation methodology should be recommended. Actual heating energy use was monitored and compared to results from the Air Conditioning Contractors of America’s Manual J8 (MJ8) and the Passive House Planning Package software. Results from that research indicate that MJ8 significantly oversizes heating systems for superinsulated homes and that thermal inertia and internal gains should be considered for more accurate load calculations.

On early starters and late bloomers: the development of sexual behavior in adolescence across personality types.

Science.gov (United States)

Baams, Laura; Overbeek, Geertjan; Dubas, Judith Semon; van Aken, Marcel A G

2014-01-01

Little is known about the relationship between personality and sexual development among mid-adolescents. In the current study, we used a person-centered approach to investigate the relation between personality types and the development of sexual behavior. We hypothesized that undercontrolling adolescents would engage in more advanced, casual, and risky sexual behavior compared to their resilient and overcontrolling peers. Data were used from 407 mid-adolescents (Mage = 14.5) followed across four measurement waves spanning 18 months. Results from latent class analyses (LCA) identified the three classical personality types: resilients, undercontrollers, and overcontrollers. Controlling for perceived pubertal timing and biological sex, latent growth curve analyses in Mplus showed that, at baseline, undercontrollers were more sexually experienced and engaged in more casual and risky sexual behavior than resilients and overcontrollers. Although initial levels of sexual behavior differed by personality types, over time increases in sexual behavior occurred at a similar rate across the types. Overall, the current study showed that undercontrolling adolescents are early sexual developers who engage in more advanced, casual, and risky sexual behavior than other adolescents. The implications of these findings for longer-term differences in sexual behavior between personality types in later adolescence are discussed.

Advanced Thermo-Adsorptive Battery: Advanced Thermo-Adsorptive Battery Climate Control System

Energy Technology Data Exchange (ETDEWEB)

None

2011-12-31

HEATS Project: MIT is developing a low-cost, compact, high-capacity, advanced thermoadsorptive battery (ATB) for effective climate control of EVs. The ATB provides both heating and cooling by taking advantage of the materials’ ability to adsorb a significant amount of water. This efficient battery system design could offer up as much as a 30% increase in driving range compared to current EV climate control technology. The ATB provides high-capacity thermal storage with little-to-no electrical power consumption. The ATB is also looking to explore the possibility of shifting peak electricity loads for cooling and heating in a variety of other applications, including commercial and residential buildings, data centers, and telecom facilities.

Integrating personality structure, personality process, and personality development

NARCIS (Netherlands)

Baumert, Anna; Schmitt, Manfred; Perugini, Marco; Johnson, Wendy; Blum, Gabriela; Borkenau, Peter; Costantini, Giulio; Denissen, J.J.A.; Fleeson, William; Grafton, Ben; Jayawickreme, Eranda; Kurzius, Elena; MacLeod, Colin; Miller, Lynn C.; Read, Stephen J.; Robinson, Michael D.; Wood, Dustin; Wrzus, Cornelia

2017-01-01

In this target article, we argue that personality processes, personality structure, and personality development have to be understood and investigated in integrated ways in order to provide comprehensive responses to the key questions of personality psychology. The psychological processes and

Evaluation of Advanced Nonlinear Static Procedure

Directory of Open Access Journals (Sweden)

Mohsen Ali Shayanfar

2015-03-01

Full Text Available Having very simplicity, nonlinear static procedures (NSPs are the most popular tools for estimation of structural capacity. These approaches construct a graphic display of the overall structural response via a pushover curve. The overall response of the system provides a direct simulation of the building as single degree of freedom (SDOF system that simplifies the design and evaluation of the structure. In this research, the first step in any nonlinear static analysis or in other words perform a pushover analysis has been studied. Applied lateral load to the structural model not only affects the overall responses of the structure through structural capacity curve, but also directly affects the local responses of the structure. In order to evaluate these lateral loads, steel buckling restrained braced frame structures are examined by advanced modal pushovers. Next, the results of these pushover analyses will be compared with nonlinear time history analysis as the most accurate method. Finally, the most efficient method in this particular structure is introduced. The analysis conducted in these structures shows that the lateral load pattern based on story shears offers a good prediction of the maximum response of the concentrically buckling restrained braced frame buildings.

Assessment of demand-response-driven load pattern elasticity using a combined approach for smart households

NARCIS (Netherlands)

Paterakis, N.G.; Tascikaraoglu, A.; Erdinç, O.; Bakirtzis, A.G.; Catalaõ, J.P.S.

2016-01-01

The recent interest in the smart grid vision and the technological advancement in the communication and control infrastructure enable several smart applications at different levels of the power grid structure, while specific importance is given to the demand side. As a result, changes in load

Advanced Pediatric Brain Imaging Research Program

Science.gov (United States)

2016-10-01

pediatric magnetic resonance imaging ( MRI ) techniques are revolutionizing our understanding of brain injury, its potential for recovery, and...training program, advanced MRI , brain injury. 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE...is located at www.MilitaryMedED.com. The site can be accessed from any device web browser (personal computer, tablet or phone) and operating system

Predictors of advanced chronic kidney disease and end-stage renal disease in HIV-positive persons

DEFF Research Database (Denmark)

Nielsen, Lene Ryom; Mocroft, Amanda; Kirk, Ole

2014-01-01

Whilst several antiretroviral drugs have been associated with moderate chronic kidney disease (CKD), their contribution to advanced CKD and end-stage renal disease (ESRD) remain unknown.......Whilst several antiretroviral drugs have been associated with moderate chronic kidney disease (CKD), their contribution to advanced CKD and end-stage renal disease (ESRD) remain unknown....

Dynamical load factor of impact loaded shell structures

International Nuclear Information System (INIS)

Hammel, J.

1977-01-01

Dynamical loaded structures can be analysed by spectral representations, which usually lead to an enormous computational effort. If it is possible to find a fitting dynamical load factor, the dynamical problem can be reduced to a statical one. The computation of this statical problem is much simpler. The disadvantage is that the dynamical load factor usually leads to a very rough approximation. In this paper it will be shown, that by combination of these two methods, the approximation of the dynamical load factor can be improved and the consumption of computation time can be enormously reduced. (Auth.)

Fatigue analysis of CANFLEX-NU fuel elements subjected to power-cyclic loads

International Nuclear Information System (INIS)

Sim, Ki Seob; Suk, Ho Chun.

1997-08-01

This report describes the fatigue analysis of the CANDU advanced fuel, so-called CANFLEX-NU, subjected to power-cyclic loads more than 1,000. The CANFLEX-NU bundle is composed of 43 elements with natural uranium fuel. As a result, the CANFLEX-NU fuel elements will maintain good integrity under the condition of 1,500 power-cycles. (author). 4 refs., 19 figs

Sleeper Cab Climate Control Load Reduction for Long-Haul Truck Rest Period Idling

Energy Technology Data Exchange (ETDEWEB)

Lustbader, J. A.; Kreutzer, C.; Adelman, S.; Yeakel, S.; Zehme, J.

2015-04-29

Annual fuel use for long-haul truck rest period idling is estimated at 667 million gallons in the United States. The U.S. Department of Energy’s National Renewable Energy Laboratory’s CoolCab project aims to reduce heating, ventilating, and air conditioning (HVAC) loads and resulting fuel use from rest period idling by working closely with industry to design efficient long-haul truck climate control systems while maintaining occupant comfort. Enhancing the thermal performance of cab/sleepers will enable smaller, lighter, and more cost-effective idle reduction solutions. In order for candidate idle reduction technologies to be implemented at the original equipment manufacturer and fleet level, their effectiveness must be quantified. To address this need, a number of promising candidate technologies were evaluated through experimentation and modeling to determine their effectiveness in reducing rest period HVAC loads. For this study, load reduction strategies were grouped into the focus areas of solar envelope, occupant environment, and conductive pathways. The technologies selected for a complete-cab package of technologies were “ultra-white” paint, advanced insulation, and advanced curtains. To measure the impact of these technologies, a nationally-averaged solar-weighted reflectivity long-haul truck paint color was determined and applied to the baseline test vehicle. Using the complete-cab package of technologies, electrical energy consumption for long-haul truck daytime rest period air conditioning was reduced by at least 35% for summer weather conditions in Colorado. The National Renewable Energy Laboratory's CoolCalc model was then used to extrapolate the performance of the thermal load reduction technologies nationally for 161 major U.S. cities using typical weather conditions for each location over an entire year.

Research of Impact Load in Large Electrohydraulic Load Simulator

Directory of Open Access Journals (Sweden)

Yongguang Liu

2014-01-01

Full Text Available The stronger impact load will appear in the initial phase when the large electric cylinder is tested in the hardware-in-loop simulation. In this paper, the mathematical model is built based on AMESim, and then the reason of the impact load is investigated through analyzing the changing tendency of parameters in the simulation results. The inhibition methods of impact load are presented according to the structural invariability principle and applied to the actual system. The final experimental result indicates that the impact load is inhibited, which provides a good experimental condition for the electric cylinder and promotes the study of large load simulator.

A novel approach for UI charge reduction using AMI based load prioritization in smart grid

Directory of Open Access Journals (Sweden)

Avani Pujara

2017-09-01

Full Text Available System frequency is vital part for power system balance. As per India Electricity Grid code frequency should be in the range of 49.5 Hz–50.5 Hz. Deviation from above mentioned range is charged as Unscheduled Interchange (UI charge. This paper proposes a new method for load and frequency control based on control of third parameter of three-part Availability Based Tariff (ABT i.e. Unscheduled Interchange charges. New circuit is designed considering prioritization of load and using Advanced Metering Infrastructure (AMI under Smart Grid environment.

The Hopper: A Wearable Robotic Device Testbed for Micro-Gravity Bone-Loading Proof-of-Concept

Science.gov (United States)

Beck, C. E.; Rovekamp, R. N.; Neuhaus, P. D.

2015-01-01

Wearable robotic systems are showing increased potential for addressing crew countermeasures needs. Wearable robots offer a compactness, programmability, and eccentric loading capability not present in more conventional exercise equipment. Correspondingly, advancements in the man to machine interface has progressed, allowing for higher loads to be applied directly to the person in new and novel ways. Recently, the X1 exoskeleton, a lower extremity wearable robot originally designed for mobility assistance and rehabilitation, underwent human subject testing to assess its potential as a knee dynamometer. This was of interest to NASA physiologists because currently strength is not assessed in flight due to hardware limitations, and thus there is a poor understanding of the time course of in-flight changes to muscle strength. The study concluded that the X1 compared well with the Biodex, the "gold standard" in terrestrial dynamometry, with coefficients of variation less than 6.0%. In a following study, the X1 powered ankle was evaluated for its efficacy in exercising calf muscles. Current on-orbit countermeasures equipment does not adequately protect the calf from atrophy. The results of this study were also positive (targeted muscle activity demonstrated via comparing pre- and post-exercise magnetic resonance imaging T2 measurements), again showing the efficacy of wearable robotic devices for addressing the countermeasure needs of our astronauts. Based on these successes and lessons learned, the Grasshopper was co-developed between IHMC (Florida Institute for Human and Machine Cognition) and NASA. The Grasshopper, or the Hopper for short, is a wearable robotic device designed to address muscle and bone density loss for astronauts spending extended periods of time in micro-gravity. The Grasshopper connects to the user's torso like a hiking backpack, over the shoulders and around the waist. At the feet are footplates that strap to the user. There are two actuators, one

Piping benchmark problems for the General Electric Advanced Boiling Water Reactor

International Nuclear Information System (INIS)

Bezler, P.; DeGrassi, G.; Braverman, J.; Wang, Y.K.

1993-08-01

To satisfy the need for verification of the computer programs and modeling techniques that will be used to perform the final piping analyses for an advanced boiling water reactor standard design, three benchmark problems were developed. The problems are representative piping systems subjected to representative dynamic loads with solutions developed using the methods being proposed for analysis for the advanced reactor standard design. It will be required that the combined license holders demonstrate that their solutions to these problems are in agreement with the benchmark problem set

Evaluation of a Person-Centered, Theory-Based Intervention to Promote Health Behaviors.

Science.gov (United States)

Worawong, Chiraporn; Borden, Mary Jo; Cooper, Karen M; Pérez, Oscar A; Lauver, Diane

Effective promotion of health behaviors requires strong interventions. Applying person-centered approaches and concepts synthesized from two motivational theories could strengthen the effects of such interventions. The aim of the study was to report the effect sizes, fidelity, and acceptability of a person-centered, health behavior intervention based on self-regulation and self-determination theories. Using a pre- and postintervention design, with a 4-week follow-up, advanced practice registered nurses made six weekly contacts with 52 volunteer participants. Most participants were educated White women. Advanced practice registered nurses elicited participant motives and particular goals for either healthy diet or physical activity behaviors. Minutes and type of activity and servings of fat and fruit/vegetables were assessed. Effect sizes for engaging in moderate aerobic activity and in fruit/vegetable and fat intake were 0.53, 0.82, and -0.57, respectively. The fidelity of delivery was 80-97% across contacts, and fidelity of participants' receipt of intervention components was supported. Participant acceptance of the intervention was supported by positive ratings on aspects of relevance and usefulness. To advance the science of health behavior change and improve client health status, person-centered approaches and concepts synthesized from motivational theories can be applied and tested with a randomized, controlled design and diverse samples to replicate and extend this promising behavioral intervention.

Load research manual. Volume 2. Fundamentals of implementing load research procedures

Energy Technology Data Exchange (ETDEWEB)

Brandenburg, L.; Clarkson, G.; Grund, Jr., C.; Leo, J.; Asbury, J.; Brandon-Brown, F.; Derderian, H.; Mueller, R.; Swaroop, R.

1980-11-01

This three-volume manual presents technical guidelines for electric utility load research. Special attention is given to issues raised by the load data reporting requirements of the Public Utility Regulatory Policies Act of 1978 and to problems faced by smaller utilities that are initiating load research programs. In Volumes 1 and 2, procedures are suggested for determining data requirements for load research, establishing the size and customer composition of a load survey sample, selecting and using equipment to record customer electricity usage, processing data tapes from the recording equipment, and analyzing the data. Statistical techniques used in customer sampling are discussed in detail. The costs of load research also are estimated, and ongoing load research programs at three utilities are described. The manual includes guides to load research literature and glossaries of load research and statistical terms.

Motivation for aggressive religious radicalization: goal regulation theory and a personality × threat × affordance hypothesis

OpenAIRE

McGregor, Ian; Hayes, Joseph; Prentice, Mike

2015-01-01

A new set of hypotheses is presented regarding the cause of aggressive religious radicalization (ARR). It is grounded in classic and contemporary theory of human motivation and goal regulation, together with recent empirical advances in personality, social, and neurophysiological psychology. We specify personality traits, threats, and group affordances that combine to divert normal motivational processes toward ARR. Conducive personality traits are oppositional, anxiety-prone, and identity-we...

Motivation for Aggressive Religious Radicalization: Goal Regulation Theory and a Personality × Threat × Affordance Hypothesis

OpenAIRE

Ian eMcGregor; Joseph eHayes; Mike ePrentice; Mike ePrentice

2015-01-01

A new set of hypotheses is presented regarding the cause of aggressive religious radicalization. It is grounded in classic and contemporary theory of human motivation and goal regulation, together with recent empirical advances in personality, social, and neurophysiological psychology. We specify personality traits, threats, and group affordances that combine to divert normal motivational processes toward aggressive religious radicalization. Conducive personality traits are oppositional, anxi...

The role of statistics in operations research: Some personal re ections

African Journals Online (AJOL)

The role of statistics in operations research: Some personal re ections. ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search · USING AJOL ... Statistics has a very important role to play in Operations Research (OR), yet many ...

32 CFR 700.809 - Persons found under incriminating circumstances.

Science.gov (United States)

2010-07-01

... offense, he shall be released at the earliest opportunity, except: (1) If not a citizen of the United... immigration authorities shall be notified as to the time and place of release sufficiently in advance to..., at the first opportunity, deliver such person, together with a statement of the circumstances, to the...

Effect of ripple loads on sustained-load cracking in titanium alloys

International Nuclear Information System (INIS)

Pao, P.S.; Meyn, D.A.; Bayles, R.A.; Feng, C.R.; Yoder, G.R.

1995-01-01

In the present paper, the authors have extended their study on the effect of the ripple loads on the sustained-load cracking (SLC) behavior of two titanium alloys, Ti-6Al-4V (an α-β alloy) and Ti-15V-3Cr-3Al-3Sn (a β-α alloy), in an ambient air environment. The methodology which has been used successfully to treat ripple effects on stress-corrosion cracking (SCC) is employed again to address the influence of ripple loads on sustained-load cracking. Ripple loads can significantly reduce the apparent sustained load cracking resistance of titanium alloys in a relatively benign environment such as ambient air. For a ripple-load amplitude equal to 5% of the sustained load, the ripple-load cracking thresholds (K IRLC ) of beta-annealed Ti-6Al-4V and Ti-15V-3Cr-3al-3Sn are less than half of the respective sustained-load cracking thresholds (K ISLC ). The extent of ripple-load degradation for these alloys in ambient air -- relative to K ISLC , were found comparable to those observed in a much more aggressive 3.5% NaCl aqueous solution

Chlorobenzylidenemalonitrile Gas Exposure from A Novelty Personal-Protection Gun

Directory of Open Access Journals (Sweden)

Dong, Christopher

2007-05-01

Full Text Available We present an unusual case of chlorobenzylidenemalonitrile (CS tear-gas exposure from the unwitting discharge of a personal-protection handgun loaded with CS gas. The gun was in a bag of toys purchased from a local thrift store and was discharged by a child. The responding paramedic presumptively identified the substance as CS based solely on personal experience. This recognition led to suboptimal field management of the incident with the paramedic failing to follow the standard operating procedures for an unknown chemical exposure. As this was a benign agent, there were no serious consequences. This case highlights the pre-hospital and emergency department challenges associated with the management of an unknown chemical exposure and the potential consequences if the chemical is a toxic substance. A methodical approach following established protocols can reduce the potential for negative outcomes. Review of the literature found no other report of CS gas exposure from such a personal-protection weapon.

Sands subjected to repetitive vertical loading under zero lateral strain: accumulation models, terminal densities, and settlement

KAUST Repository

Chong, Song Hun

2016-08-09

Geosystems often experience numerous loading cycles. Plastic strain accumulation during repetitive mechanical loads can lead to shear shakedown or continued shear ratcheting; in all cases, volumetric strains diminish as the specimen evolves towards terminal density. Previously suggested models and new functions are identified to fit plastic strain accumulation data. All accumulation models are formulated to capture terminal density (volumetric strain) and either shakedown or ratcheting (shear strain). Repetitive vertical loading tests under zero lateral strain conditions are conducted using three different sands packed at initially low and high densities. Test results show that plastic strain accumulation for all sands and density conditions can be captured in the same dimensionless plot defined in terms of the initial relative density, terminal density, and ratio between the amplitude of the repetitive load and the initial static load. This observation allows us to advance a simple but robust procedure to estimate the maximum one-dimensional settlement that a foundation could experience if subjected to repetitive loads. © 2016, Canadian Science Publishing. All rights reserved.

A pilot study to evaluate the magnitude of association of the use of electronic personal health records with patient activation and empowerment in HIV-infected veterans

Directory of Open Access Journals (Sweden)

Pierre-Cédric B. Crouch

2015-03-01

Full Text Available The HITECH Act signed into law in 2009 requires hospitals to provide patients with electronic access to their health information through an electronic personal health record (ePHR in order to receive Medicare/Medicaid incentive payments. Little is known about who uses these systems or the impact these systems will have on patient outcomes in HIV care. The health care empowerment model provides rationale for the hypothesis that knowledge from an electronic personal health record can lead to greater patient empowerment resulting in improved outcomes. The objective was to determine the patient characteristics and patient activation, empowerment, satisfaction, knowledge of their CD4, Viral Loads, and antiretroviral medication, and medication adherence outcomes associated with electronic personal health record use in Veterans living with HIV at the San Francisco VA Medical Center. The participants included HIV-Infected Veterans receiving care in a low volume HIV-clinic at the San Francisco VA Medical Center, divided into two groups of users and non-users of electronic personal health records. The research was conducted using in-person surveys either online or on paper and data abstraction from medical records for current anti-retroviral therapy (ART, CD4 count, and plasma HIV-1 viral load. The measures included the Patient Activation Measure, Health Care Empowerment Inventory, ART adherence, provider satisfaction, current CD4 count, current plasma viral load, knowledge of current ART, knowledge of CD4 counts, and knowledge of viral load. In all, 40 participants were recruited. The use of electronic personal health records was associated with significantly higher levels of patient activation and levels of patient satisfaction for getting timely appointments, care, and information. ePHR was also associated with greater proportions of undetectable plasma HIV-1 viral loads, of knowledge of current CD4 count, and of knowledge of current viral load. The

21 CFR 1313.24 - Waiver of 15-day advance notice for chemical exporters.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Waiver of 15-day advance notice for chemical... IMPORTATION AND EXPORTATION OF LIST I AND LIST II CHEMICALS Exportation of Listed Chemicals § 1313.24 Waiver of 15-day advance notice for chemical exporters. (a) Each regulated person shall provide to the...

Open Access Integrated Therapeutic and Diagnostic Platforms for Personalized Cardiovascular Medicine

Directory of Open Access Journals (Sweden)

Todd T. Schlegel

2013-08-01

Full Text Available It is undeniable that the increasing costs in healthcare are a concern. Although technological advancements have been made in healthcare systems, the return on investment made by governments and payers has been poor. The current model of care is unsustainable and is due for an upgrade. In developed nations, a law of diminishing returns has been noted in population health standards, whilst in the developing world, westernized chronic illnesses, such as diabetes and cardiovascular disease have become emerging problems. The reasons for these trends are complex, multifactorial and not easily reversed. Personalized medicine has the potential to have a significant impact on these issues, but for it to be truly successful, interdisciplinary mass collaboration is required. We propose here a vision for open-access advanced analytics for personalized cardiac diagnostics using imaging, electrocardiography and genomics.

Limitations of power conversion systems under transient loads and impact on the pulsed tokamak power reactor

International Nuclear Information System (INIS)

Sager, G.T.; Wong, C.P.C.; Kapich, D.D.; McDonald, C.F.; Schleicher, R.W.

1993-11-01

The impact of cyclic loading of the power conversion system of a helium-cooled, pulsed tokamak power plant is assessed. Design limits of key components of heat transport systems employing Rankie and Brayton thermodynamic cycles are quantified based on experience in gas-cooled fission reactor design and operation. Cyclic loads due to pulsed tokamak operation are estimated. Expected performance of the steam generator is shown to be incompatible with pulsed tokamak operation without load leveling thermal energy storage. The close cycle gas turbine is evaluated qualitatively based on performance of existing industrial and aeroderivative gas turbines. Advances in key technologies which significantly improve prospects for operation with tokamak fusion plants are reviewed

Efficient Resources Provisioning Based on Load Forecasting in Cloud

Directory of Open Access Journals (Sweden)

Rongdong Hu

2014-01-01

Full Text Available Cloud providers should ensure QoS while maximizing resources utilization. One optimal strategy is to timely allocate resources in a fine-grained mode according to application’s actual resources demand. The necessary precondition of this strategy is obtaining future load information in advance. We propose a multi-step-ahead load forecasting method, KSwSVR, based on statistical learning theory which is suitable for the complex and dynamic characteristics of the cloud computing environment. It integrates an improved support vector regression algorithm and Kalman smoother. Public trace data taken from multitypes of resources were used to verify its prediction accuracy, stability, and adaptability, comparing with AR, BPNN, and standard SVR. Subsequently, based on the predicted results, a simple and efficient strategy is proposed for resource provisioning. CPU allocation experiment indicated it can effectively reduce resources consumption while meeting service level agreements requirements.

Switzerland advances payments to CERN

CERN Multimedia

2002-01-01

In the picture, Charles Kleiber (third from left) visits the TI8 tunnel with (left to right) Jean-Luc Baldy, Head of the LHC civil engineering group, Luciano Maiani, CERN Director-General, Jean-Pierre Ruder, Swiss Delegate to CERN Council, Guy Hentsch, Personal adviser to the Director-General, Michel Buchs and Frédéric Chavan, representatives of the firm Prader Losinger. The State Secretary for Science and Research in Switzerland, Charles Kleiber, signed an agreement with CERN last week for an advancement of contributions from his country. The Confédération Helvétique will make an advanced payment of 90 million CHF. There will be no interest involved in this payment and the amount of money will be deducted from Switzerland's ordinary contributions to CERN in later years.

Effects of wearing different personal equipment on force distribution at the plantar surface of the foot.

Science.gov (United States)

Schulze, Christoph; Lindner, Tobias; Woitge, Sandra; Finze, Susanne; Mittelmeier, Wolfram; Bader, Rainer

2013-01-01

The wearing of personal equipment can cause specific changes in muscle activity and posture. In the present study, we investigated the influence of differences in equipment related weight loading and load distribution on plantar pressure. In addition, we studied functional effects of wearing different equipment with a particular focus on relevant changes in foot shape. Static and dynamic pedobarography were performed on 31 male soldiers carrying increasing weights consisting of different items of equipment. The pressure acting on the plantar surface of the foot increased with higher loading, both under static and dynamic conditions (p feet deformities which seem to flatten at an earlier load condition with a greater amount compared to subjects with normal arches. Improving load distribution should be a main goal in the development of military equipment in order to prevent injuries or functional disorders of the lower extremity.

Comparative Effectiveness Research, Genomics-Enabled Personalized Medicine, and Rapid Learning Health Care: A Common Bond

Science.gov (United States)

Ginsburg, Geoffrey S.; Kuderer, Nicole M.

2012-01-01

Despite stunning advances in our understanding of the genetics and the molecular basis for cancer, many patients with cancer are not yet receiving therapy tailored specifically to their tumor biology. The translation of these advances into clinical practice has been hindered, in part, by the lack of evidence for biomarkers supporting the personalized medicine approach. Most stakeholders agree that the translation of biomarkers into clinical care requires evidence of clinical utility. The highest level of evidence comes from randomized controlled clinical trials (RCTs). However, in many instances, there may be no RCTs that are feasible for assessing the clinical utility of potentially valuable genomic biomarkers. In the absence of RCTs, evidence generation will require well-designed cohort studies for comparative effectiveness research (CER) that link detailed clinical information to tumor biology and genomic data. CER also uses systematic reviews, evidence-quality appraisal, and health outcomes research to provide a methodologic framework for assessing biologic patient subgroups. Rapid learning health care (RLHC) is a model in which diverse data are made available, ideally in a robust and real-time fashion, potentially facilitating CER and personalized medicine. Nonetheless, to realize the full potential of personalized care using RLHC requires advances in CER and biostatistics methodology and the development of interoperable informatics systems, which has been recognized by the National Cancer Institute's program for CER and personalized medicine. The integration of CER methodology and genomics linked to RLHC should enhance, expedite, and expand the evidence generation required for fully realizing personalized cancer care. PMID:23071236

Personality Traits and Second Language Acquisition: The Influence of the Enneagram on Adult ESOL Students

Science.gov (United States)

Coker, Crystal; Mihai, Florin

2017-01-01

In this qualitative study, researchers focused on providing explicit knowledge of personality traits via the Enneagram profile to a group of 10 adult advanced students of English for speakers of other languages. Through the Enneagram and two surveys, researchers gained insight into how students perceived the influence of their personality type on…

Personality goes a long a way: an interhemispheric connectivity study

Directory of Open Access Journals (Sweden)

Sylco S. Hoppenbrouwers

2010-11-01

Full Text Available Throughout the development of psychology the delineation of personality has played a central role. Together with the NEO-PI-R, a questionnaire derived from the Five Factor Model of Personality, and recent advances in research technology it is now possible to investigate the relationship between personality features and neurophysiological brain processes. The NEO-FFI, the short version of the NEO-PI-R, reliably measures five main personality traits: Neuroticism, Extraversion, Openness to experience, Agreeableness and Conscientiousness. As behaviour and some psychiatric disorders have been related to interhemispheric connectivity, the present study used the combination of transcranial magnetic stimulation (TMS and electroencephalography (EEG to measure frontal interhemispheric connectivity and its association with personality as indexed by the NEO-FFI. Results demonstrated that prefrontal interhemispheric connectivity between the left and right dorsolateral prefrontal cortex (DLPFC correlates with Agreeableness in healthy subjects. This is the first study to relate personality features to interhemispheric connectivity through TMS-EEG and suggests that Agreeableness relates to the effectiveness of prefrontal communication between hemispheres.

End-Of-Life Care for Persons with Advanced Chronic Obstructive Pulmonary Disease: Report of a National Interdisciplinary Consensus Meeting

Directory of Open Access Journals (Sweden)

DM Goodridge

2009-01-01

Full Text Available While systemic shortcomings in meeting the needs of individuals with progressive chronic illnesses at the end of life have been well documented, there is growing interest in improving both care and quality of life for persons with advanced chronic obstructive pulmonary disease (COPD. For instance, the American Thoracic Society has issued an official statement on palliative care for patients with respiratory diseases, affirming that the prevention, relief, reduction and soothing of symptoms “without affecting a cure” must become an integral component of standard care. A recent Medline search located 1015 articles related to palliative or end-of-life care for people with COPD published between 2001 and 2008, compared with only 336 articles published before 2001. To address the needs of Canadian patients, an interdisciplinary consensus meeting, funded by the Canadian Institutes of Health Research and supported by the Canadian Thoracic Society, the Canadian Respiratory Health Professionals and the Canadian Lung Association was convened in Toronto, Ontario, on November 22, 2008, to begin examining the quality of end-of-life care for individuals with COPD in Canada. The present report summarizes the background to and outcomes of this consensus meeting.

The effects of working memory load and attention refocusing on delay discounting rates in alcohol use disorder with comorbid antisocial personality disorder.

Science.gov (United States)

Gunn, Rachel L; Gerst, Kyle R; Lake, Allison J; Finn, Peter R

2018-02-01

Executive working memory capacity (eWMC) is central to adaptive decision-making. Research has revealed reduced eWMC and higher rates of impulsive decision making in individuals with alcohol use disorders (AUDs: DSM-IV Alcohol Dependence of Alcohol Abuse) and antisocial psychopathology (AP). Recent work has shown that placing a load on working memory (WM) further increases impulsive decision making on the delay discounting (DD) task in those with AUDs and AP. The current study examined the effects of an attention refocusing manipulation to offset the effects of this WM-load on DD rates in control subjects, those with AUDs without AP, and AUDs with AP (AUD-AP). Results revealed that 1) the AUD-AP group had higher DD rates (i.e., more impulsive decision-making) than the AUD group, followed by controls, and 2) attention refocusing after a load is placed on WM was associated with lower DD rates compared to the load without refocusing in both AUD groups, but not controls. Results suggest that refocusing attention after a cognitive load may be an effective cognitive strategy for reducing the impulsivity-enhancing effects of cognitive load on decision making in individuals with AUDs and AP. Copyright © 2017 Elsevier Inc. All rights reserved.

Major breakthrough in personal dust protection

Energy Technology Data Exchange (ETDEWEB)

Chadwick, J.

2004-09-15

With new studies highlighting one in every 20 miners developing 'black lung', USA labour, industry and government have joined forces to develop a solution. The rapid advance in Personal Dust Monitor (PDM) technology is a perfect example. The article reports a PDM, which is developed by the US National Institute for Occupational Safety and Health, working in the partnership with the United Mine Workers of America, the Bituminous Coal Operators Association and the National Mining Association.

Problems of dentistrical prophylactic medical examination of persons dealing with ionizing radiation sources

International Nuclear Information System (INIS)

Kalinin, V.I.; Ramzaeva, L.V.; Zamanova, L.V.

1988-01-01

A comparative study of data of individual dosimetric control of radiological personnel and additional radiation contribution of annual fluoroscopy of chest into radiation load was carried out. It is stated that chest fluoroscopy adds 13 % of collective dose to the occupational irradiation. Efficiency of preventive chest fluoroscopic examination was simultaneously analyzed in 1388 persons engaged in occupational radiology. Investigation results permit to state a question on advisability of transition to differential chest fluoroscopic examination in persons of A category, being guided by clinical indications and potential risk of carcinogenesis and tuberculosis. 5 refs

Ductless personalized ventilation with local air cleaning

DEFF Research Database (Denmark)

Dalewski, Mariusz; Vesely, Michal; Melikov, Arsen Krikor

2012-01-01

An experiment with 28 human subjects was performed to examine effects of using a local air cleaning device combined with ductless personalized ventilation (DPV) on perceived air quality. Experiments were performed in a test room with displacement ventilation. The DPV at one of two desks was equip......An experiment with 28 human subjects was performed to examine effects of using a local air cleaning device combined with ductless personalized ventilation (DPV) on perceived air quality. Experiments were performed in a test room with displacement ventilation. The DPV at one of two desks...... was equipped with an activated carbon filter installed at the air intake, while the DPV at the second desk was without such a filter. The air temperature in the occupied zone (1.1 m above the floor) was 29 °C. The pollution load in the room was simulated by PVC floor covering. The subjects assessed...

Using Airborne LIDAR Data for Assessment of Forest Fire Fuel Load Potential