Sample records for advanced diagnostic methodology

  1. Methodological advances

    Lebreton, J.-D.


    Full Text Available The study of population dynamics has long depended on methodological progress. Among many striking examples, continuous time models for populations structured in age (Sharpe & Lotka, 1911 were made possible by progress in the mathematics of integral equations. Therefore the relationship between population ecology and mathematical and statistical modelling in the broad sense raises a challenge in interdisciplinary research. After the impetus given in particular by Seber (1982, the regular biennial EURING conferences became a major vehicle to achieve this goal. It is thus not surprising that EURING 2003 included a session entitled “Methodological advances”. Even if at risk of heterogeneity in the topics covered and of overlap with other sessions, such a session was a logical way of ensuring that recent and exciting new developments were made available for discussion, further development by biometricians and use by population biologists. The topics covered included several to which full sessions were devoted at EURING 2000 (Anderson, 2001 such as: individual covariates, Bayesian methods, and multi–state models. Some other topics (heterogeneity models, exploited populations and integrated modelling had been addressed by contributed talks or posters. Their presence among “methodological advances”, as well as in other sessions of EURING 2003, was intended as a response to their rapid development and potential relevance to biological questions. We briefly review all talks here, including those not published in the proceedings. In the plenary talk, Pradel et al. (in prep. developed GOF tests for multi–state models. Until recently, the only goodness–of–fit procedures for multistate models were ad hoc, and non optimal, involving use of standard tests for single state models (Lebreton & Pradel, 2002. Pradel et al. (2003 proposed a general approach based in particular on mixtures of multinomial distributions. Pradel et al. (in prep. showed

  2. Methodological Advances in Dea

    L. Cherchye (Laurens); G.T. Post (Thierry)


    textabstractWe survey the methodological advances in DEA over the last 25 years and discuss the necessary conditions for a sound empirical application. We hope this survey will contribute to the further dissemination of DEA, the knowledge of its relative strengths and weaknesses, and the tools

  3. 76 FR 23825 - Study Methodologies for Diagnostics in the Postmarket Setting; Public Workshop


    ... HUMAN SERVICES Food and Drug Administration Study Methodologies for Diagnostics in the Postmarket... Diagnostics in the Postmarket Setting.'' The purpose of the public workshop is to provide a forum for... epidemiology, statistics, diagnostics, and biomedical research to advance the methodologies for diagnostics...

  4. Scoping studies: advancing the methodology

    O'Brien Kelly K


    Full Text Available Abstract Background Scoping studies are an increasingly popular approach to reviewing health research evidence. In 2005, Arksey and O'Malley published the first methodological framework for conducting scoping studies. While this framework provides an excellent foundation for scoping study methodology, further clarifying and enhancing this framework will help support the consistency with which authors undertake and report scoping studies and may encourage researchers and clinicians to engage in this process. Discussion We build upon our experiences conducting three scoping studies using the Arksey and O'Malley methodology to propose recommendations that clarify and enhance each stage of the framework. Recommendations include: clarifying and linking the purpose and research question (stage one; balancing feasibility with breadth and comprehensiveness of the scoping process (stage two; using an iterative team approach to selecting studies (stage three and extracting data (stage four; incorporating a numerical summary and qualitative thematic analysis, reporting results, and considering the implications of study findings to policy, practice, or research (stage five; and incorporating consultation with stakeholders as a required knowledge translation component of scoping study methodology (stage six. Lastly, we propose additional considerations for scoping study methodology in order to support the advancement, application and relevance of scoping studies in health research. Summary Specific recommendations to clarify and enhance this methodology are outlined for each stage of the Arksey and O'Malley framework. Continued debate and development about scoping study methodology will help to maximize the usefulness and rigor of scoping study findings within healthcare research and practice.

  5. Methodology, models and algorithms in thermographic diagnostics

    Živčák, Jozef; Madarász, Ladislav; Rudas, Imre J


    This book presents  the methodology and techniques of  thermographic applications with focus primarily on medical thermography implemented for parametrizing the diagnostics of the human body. The first part of the book describes the basics of infrared thermography, the possibilities of thermographic diagnostics and the physical nature of thermography. The second half includes tools of intelligent engineering applied for the solving of selected applications and projects. Thermographic diagnostics was applied to problematics of paraplegia and tetraplegia and carpal tunnel syndrome (CTS). The results of the research activities were created with the cooperation of the four projects within the Ministry of Education, Science, Research and Sport of the Slovak Republic entitled Digital control of complex systems with two degrees of freedom, Progressive methods of education in the area of control and modeling of complex object oriented systems on aircraft turbocompressor engines, Center for research of control of te...

  6. Advances in medical diagnostic technology

    Lai, Khin Wee; Mohamad Salim, Maheza Irna; Ong, Sang-Bing; Utama, Nugraha Priya; Myint, Yin Mon; Mohd Noor, Norliza; Supriyanto, Eko


    This book provides the most recent findings and knowledge in advanced diagnostics technology, covering a wide spectrum including brain activity analysis, breast and lung cancer detection, echocardiography, computer aided skeletal assessment to mitochondrial biology imaging at the cellular level. The authors explored magneto acoustic approaches and tissue elasticity imaging for the purpose of breast cancer detection. Perspectives in fetal echocardiography from an image processing angle are included. Diagnostic imaging in the field of mitochondrial diseases as well as the use of Computer-Aided System (CAD) are also discussed in the book. This book will be useful for students, lecturers or professional researchers in the field of biomedical sciences and image processing.

  7. [Vasculitis - diagnostic and therapeutic advances].

    De Albuquerque, R; Machado, Filipa


    Vasculitis is characterized by inflammation and necrosis of blood vessels walls. It represents a heterogeneous group of conditions, whose etiopathogenic mechanisms remain unclear. Although uncommon, with an annual incidence of 40-54 cases per 1.000.000 persons, this is an important cause of multiorganic dysfunction and premature mortality. Depending on the affected vessels, it can cause diverse clinical presentations, which makes difficult its recognition. It is therefore a challenge for any clinician. This paper reviews the diagnostic and therapeutic advances of the most common forms of vasculitis, in order to optimize the approach and management of this clinical entity. We have conducted a search in Medline database on articles written in English, published for the last 10 years using the keywords: vasculitis, epidemiology, classification, diagnosis and treatment. To minimize the impact of vasculitis it is essential an early diagnosis, allowing a timely institution of the appropriate treatment. The diagnosis depends on the integration of clinical, laboratory, imaging and histopathologic data. According to the clinical condition, it may be indicated the removal of the offending antigen, the treatment of the underlying disease or specific treatment of the primary vasculitis. The introduction of immunosuppressive therapy with glucocorticoids and cyclophosphamide has revolutionized the prognosis of these patients but, despite its efficacy, it is associated with frequent relapses and significant toxicity. The study of the pathogenesis has been providing more effective and safer diagnostic and therapeutic options, for example B-cell depleting agents, but additional studies are needed to confirm the potential of these alternatives.

  8. Advanced LBB methodology and considerations

    Olson, R.; Rahman, S.; Scott, P. [Battelle, Columbus, OH (United States)] [and others


    LBB applications have existed in many industries and more recently have been applied in the nuclear industry under limited circumstances. Research over the past 10 years has evolved the technology so that more advanced consideration of LBB can now be given. Some of the advanced considerations for nuclear plants subjected to seismic loading evaluations are summarized in this paper.

  9. Recent Advancements in Microwave Imaging Plasma Diagnostics

    H. Park; C.C. Chang; B.H. Deng; C.W. Domier; A.J.H. Donni; K. Kawahata; C. Liang; X.P. Liang; H.J. Lu; N.C. Luhmann, Jr.; A. Mase; H. Matsuura; E. Mazzucato; A. Miura; K. Mizuno; T. Munsat; K. and Y. Nagayama; M.J. van de Pol; J. Wang; Z.G. Xia; W-K. Zhang


    Significant advances in microwave and millimeter wave technology over the past decade have enabled the development of a new generation of imaging diagnostics for current and envisioned magnetic fusion devices. Prominent among these are revolutionary microwave electron cyclotron emission imaging (ECEI), microwave phase imaging interferometers, imaging microwave scattering and microwave imaging reflectometer (MIR) systems for imaging electron temperature and electron density fluctuations (both turbulent and coherent) and profiles (including transport barriers) on toroidal devices such as tokamaks, spherical tori, and stellarators. The diagnostic technology is reviewed, and typical diagnostic systems are analyzed. Representative experimental results obtained with these novel diagnostic systems are also presented.

  10. Methodology of diagnostic tests in hepatology

    Christensen, Erik


    The performance of diagnostic tests can be assessed by a number of methods. These include sensitivity, specificity,positive and negative predictive values, likelihood ratios and receiver operating characteristic (ROC) curves. This paper describes the methods and explains which information they pr...

  11. A diagnostic methodology for refrigerating systems; Methodologie de diagnostic des installations frigorifiques

    Vrinat, G. [Association Francaise du Froid (AFF), 75 - Paris (France)


    A diagnostic methodology for refrigerating machines, equipment and plants has been defined and evaluated for EDF, the French national power utility and ADEME, the French Agency for Energy Conservation, in the framework of energy conservation objectives: the diagnostic method should enable to identify malfunctions, assess the cost efficiency of the equipment, identify limiting factors, and consider corrective measures

  12. Advances in diagnostic testing for Alzheimer disease.

    Schindler, Suzanne E; McConathy, Jonathan; Ances, Beau M; Diamond, Marc I


    The diagnosis of Alzheimer disease (AD) dementia is based primarily on the clinical history and examination, but advances in understanding the pathophysiology of AD have led to new diagnostic methods. When used appropriately, the tests can provide strong positive or negative evidence AD dementia. This article described which patients may benefit from additional testing using Cerebrospinal Fluid (CSF) biomarkers, amyloid imaging, quantitative structural magnetic resonance imaging (MRI), and fluoro-deoxyglucose positron emission tomography (FDG-PET).

  13. Advanced planning methodologies in food supply chains

    Farahani, Poorya

    The food industry is an important sector both because of its direct impacts on the daily lives of people and its large share of GDP compared with other economic sectors. This thesis discusses and develops advanced planning methodologies to optimize operations in food supply chains. From a supply...... chain perspective, this thesis mainly focuses on the part of the chain which starts from the food processing industry: the food processing industry, the distribution industry, and final consumers. In the second chapter of this thesis, a thorough review is presented classifying the related contributions...... in strategic, tactical, and operational studies, aiming to explain how several key food distribution planning challenges have been dealt with in the Operations Management literature. The next two chapters discuss specific production and distribution planning problems from the foodservice sector. Generic...

  14. Diagnostic Tests for Alzheimer's Disease: Rationale, Methodology, and Challenges

    S. E. Mason


    Full Text Available There has been a large increase in the amount of research seeking to define or diagnose Alzheimer's disease before patients develop dementia. If successful, this would principally have clinical benefits both in terms of treatment as well as risk modification. Moreover, a better method for diagnosing predementia disease would assist research which seeks to develop such treatments and risk modification strategies. The evidence-based definition of a diagnostic test's accuracy is fundamental to achieve the above goals and to address this, the Cochrane Collaboration has established a Diagnostic Test Accuracy group dedicated to examining the utility and accuracy of proposed tests in dementia and cognitive impairment. We present here the assumptions and observations underpinning the chosen methodology as well as the initial methodological approach decided upon.

  15. Advanced Power Plant Development and Analysis Methodologies

    A.D. Rao; G.S. Samuelsen; F.L. Robson; B. Washom; S.G. Berenyi


    Under the sponsorship of the U.S. Department of Energy/National Energy Technology Laboratory, a multi-disciplinary team led by the Advanced Power and Energy Program of the University of California at Irvine is defining the system engineering issues associated with the integration of key components and subsystems into advanced power plant systems with goals of achieving high efficiency and minimized environmental impact while using fossil fuels. These power plant concepts include 'Zero Emission' power plants and the 'FutureGen' H2 co-production facilities. The study is broken down into three phases. Phase 1 of this study consisted of utilizing advanced technologies that are expected to be available in the 'Vision 21' time frame such as mega scale fuel cell based hybrids. Phase 2 includes current state-of-the-art technologies and those expected to be deployed in the nearer term such as advanced gas turbines and high temperature membranes for separating gas species and advanced gasifier concepts. Phase 3 includes identification of gas turbine based cycles and engine configurations suitable to coal-based gasification applications and the conceptualization of the balance of plant technology, heat integration, and the bottoming cycle for analysis in a future study. Also included in Phase 3 is the task of acquiring/providing turbo-machinery in order to gather turbo-charger performance data that may be used to verify simulation models as well as establishing system design constraints. The results of these various investigations will serve as a guide for the U. S. Department of Energy in identifying the research areas and technologies that warrant further support.

  16. Advanced Power Plant Development and Analyses Methodologies

    G.S. Samuelsen; A.D. Rao


    Under the sponsorship of the U.S. Department of Energy/National Energy Technology Laboratory, a multi-disciplinary team led by the Advanced Power and Energy Program of the University of California at Irvine is defining the system engineering issues associated with the integration of key components and subsystems into advanced power plant systems with goals of achieving high efficiency and minimized environmental impact while using fossil fuels. These power plant concepts include ''Zero Emission'' power plants and the ''FutureGen'' H{sub 2} co-production facilities. The study is broken down into three phases. Phase 1 of this study consisted of utilizing advanced technologies that are expected to be available in the ''Vision 21'' time frame such as mega scale fuel cell based hybrids. Phase 2 includes current state-of-the-art technologies and those expected to be deployed in the nearer term such as advanced gas turbines and high temperature membranes for separating gas species and advanced gasifier concepts. Phase 3 includes identification of gas turbine based cycles and engine configurations suitable to coal-based gasification applications and the conceptualization of the balance of plant technology, heat integration, and the bottoming cycle for analysis in a future study. Also included in Phase 3 is the task of acquiring/providing turbo-machinery in order to gather turbo-charger performance data that may be used to verify simulation models as well as establishing system design constraints. The results of these various investigations will serve as a guide for the U. S. Department of Energy in identifying the research areas and technologies that warrant further support.

  17. Mixed-signal methodology guide advanced methodology for AMS IP and SOC design, verification and implementation

    Chen, Jess; Mar, Monte F; Nizic, Mladen; Bailey, Brian


    This Book, The Mixed-Signal Methodology Guide: Advanced Methodology For Ams Ip And Soc Design, Verification, And Implementation Provides A Broad Overview Of The Design, Verification And Implementation Methodologies Required For Today's Mixed-Signal Designs. The Book Covers Mixed-Signal Design Trends And Challenges, Abstraction Of Analog Using Behavioral Models, Assertion-Based Metric-Driven Verification Methodology Applied On Analog And Mixed-Signal And Verification Of Low Power Intent In Mixed-Signal Design. It Also Describes Methodology For Physical Implementation In Context Of Concurrent Mixed-Signal Design And For Handling Advanced Node Physical Effects. The Book Contains Many Practical Examples Of Models And Techniques. The Authors Believe It Should Serve As A Reference To Many Analog, Digital And Mixed-Signal Designers, Verification, Physical Implementation Engineers And Managers In Their Pursuit Of Information For A Better Methodology Required To Address The Challenges Of Modern Mixed-Signal Design.

  18. Advanced plasma diagnostics for plasma processing

    Malyshev, Mikhail Victorovich


    A new, non-intrusive, non-perturbing diagnostic method was developed that can be broadly applied to low pressure, weakly ionized plasmas and glow discharges-trace rare gases optical emission spectroscopy (TRG-OES). The method is based on a comparison of intensities of atomic emission from trace amounts of inert gases (He, Ne, Ar, Kr, and Xe) that are added to the discharge to intensities calculated from the theoretical model. The model assumes a Maxwellian electron energy distribution function (EEDF), computes the population of emitting levels both from the ground state and the metastable states of rare gases, and from the best fit between theory and experiment determines electron temperature (Te). Subject to conditions, TRG-OES can also yield electron density or its upper or lower limit. From the comparison of the emission from levels excited predominantly by high energy electrons to that excited by low energy electrons, information about the EEDF can be obtained. The use of TRG-OES also allows a traditionally qualitative actinometry technique (determination of concentration of radical species in plasma through optical emission) to become a precise quantitative method by including Te and rare gases metastables effects. A combination of TRG-OES, advanced actinometry, and Langmuir probe measurements was applied to several different plasma reactors and regimes of operation. Te measurements and experiments to correct excitation cross section were conducted in a laboratory helical resonator. Two chamber configuration of a commercial (Lam Research) metal etcher were studied to determine the effects of plasma parameters on plasma-induced damage. Two different methods (RF inductive coupling and ultra-high frequency coupling) for generating a plasma in a prototype reactor were also studied. Pulsed plasmas, a potential candidate to eliminate the plasma-induced damage to microelectronics devices that occurs in manufacturing due to differential charging of the wafer, have

  19. Advancements of microwave diagnostics in magnetically confined plasmas

    Mase, A.; Kogi, Y.; Ito, N.; Yokota, Y.; Akaki, K.; Kawahata, K.; Nagayama, Y.; Tokuzawa, T.; Yamaguchi, S.; Hojo, H.; Oyama, N.; N C Luhmann Jr.,; Park, H. K.; Donne, A. J. H.


    Microwave to millimeter-wave diagnostic techniques such as interferometry, reflectometry, scattering and radiometry have been powerful tools for diagnosing magnetically confined plasmas. Recent advances in electronic devices and components together with computer technology have enabled the developme

  20. EMBASE search strategies for identifying methodologically sound diagnostic studies for use by clinicians and researchers

    Haynes R Brian


    Full Text Available Abstract Background Accurate diagnosis by clinicians is the cornerstone of decision making for recommending clinical interventions. The current best evidence from research concerning diagnostic tests changes unpredictably as science advances. Both clinicians and researchers need dependable access to published evidence concerning diagnostic accuracy. Bibliographic databases such as EMBASE provide the most widely available entrée to this literature. The objective of this study was to develop search strategies that optimize the retrieval of methodologically sound diagnostic studies from EMBASE for use by clinicians. Methods An analytic survey was conducted, comparing hand searches of 55 journals with retrievals from EMBASE for 4,843 candidate search terms and 6,574 combinations. All articles were rated using purpose and quality indicators, and clinically relevant diagnostic accuracy articles were categorized as 'pass' or 'fail' according to explicit criteria for scientific merit. Candidate search strategies were run in EMBASE, the retrievals being compared with the hand search data. The proposed search strategies were treated as "diagnostic tests" for sound studies and the manual review of the literature was treated as the "gold standard." The sensitivity, specificity, precision and accuracy of the search strategies were calculated. Results Of the 433 articles about diagnostic tests, 97 (22.4% met basic criteria for scientific merit. Combinations of search terms reached peak sensitivities of 100% with specificity at 70.4%. Compared with best single terms, best multiple terms increased sensitivity for sound studies by 8.2% (absolute increase, but decreased specificity (absolute decrease 6% when sensitivity was maximized. When terms were combined to maximize specificity, the single term "" (specificity of 98.2% outperformed combinations of terms. Conclusion Empirically derived search strategies combining indexing terms and textwords

  1. Diagnostics of nonlocal plasmas: advanced techniques

    Mustafaev, Alexander; Grabovskiy, Artiom; Strakhova, Anastasiya; Soukhomlinov, Vladimir


    This talk generalizes our recent results, obtained in different directions of plasma diagnostics. First-method of flat single-sided probe, based on expansion of the electron velocity distribution function (EVDF) in series of Legendre polynomials. It will be demonstrated, that flat probe, oriented under different angles with respect to the discharge axis, allow to determine full EVDF in nonlocal plasmas. It is also shown, that cylindrical probe is unable to determine full EVDF. We propose the solution of this problem by combined using the kinetic Boltzmann equation and experimental probe data. Second-magnetic diagnostics. This method is implemented in knudsen diode with surface ionization of atoms (KDSI) and based on measurements of the magnetic characteristics of the KDSI in presence of transverse magnetic field. Using magnetic diagnostics we can investigate the wide range of plasma processes: from scattering cross-sections of electrons to plasma-surface interactions. Third-noncontact diagnostics method for direct measurements of EVDF in remote plasma objects by combination of the flat single-sided probe technique and magnetic polarization Hanley method.

  2. Methodology and Supporting Toolset Advancing Embedded Systems Quality

    Berger, Michael Stübert; Soler, José; Brewka, Lukasz Jerzy


    Software quality is of primary importance in the development of embedded systems that are often used in safety-critical applications. Moreover, as the life cycle of embedded products becomes increasingly tighter, productivity and quality are simultaneously required and closely interrelated towards...... delivering competitive products. In this context, the MODUS (Methodology and supporting toolset advancing embedded systems quality) project aims to provide a pragmatic and viable solution that will allow SMEs to substantially improve their positioning in the embedded-systems development market. This paper...... will describe the MODUS project with focus on the technical methodologies that will be developed advancing embedded system quality....

  3. Methodology and Supporting Toolset Advancing Embedded Systems Quality

    Berger, Michael Stübert; Soler, José; Brewka, Lukasz Jerzy;


    Software quality is of primary importance in the development of embedded systems that are often used in safety-critical applications. Moreover, as the life cycle of embedded products becomes increasingly tighter, productivity and quality are simultaneously required and closely interrelated towards...... delivering competitive products. In this context, the MODUS (Methodology and supporting toolset advancing embedded systems quality) project aims to provide a pragmatic and viable solution that will allow SMEs to substantially improve their positioning in the embedded-systems development market. This paper...... will describe the MODUS project with focus on the technical methodologies that will be developed advancing embedded system quality....

  4. [Advances in the diagnostics of Alzheimer's disease].

    Fiedler, U; Wiltfang, J; Peters, N; Benninghoff, J


    Due to the demographic developments, diagnosis and treatment, dementia constitutes an increasing medical challenge and is likely to have an increasing socioeconomic impact. Dementia does not reflect a single disease but encompasses a variety of underlying conditions, heterogeneous clinical courses and therapeutic approaches, among which Alzheimer's disease represents the most common cause. Therefore, a thorough differential diagnosis of dementia is of major importance. To date the current diagnosis of dementia according to ICD-10/DMS-IV is based on clinical criteria. In addition, the concept of mild cognitive impairment comprises early cognitive dysfunction without clinically apparent dementia. Alzheimer's disease is more and more conceptualized as a disease continuum with mild cognitive impairment as an early and manifest dementia as the later stage of the disease. This review gives an overview on the current diagnostic approaches and the proposed revisions of diagnostic and research criteria for Alzheimer's disease.

  5. Advanced Diagnostics for High Pressure Spray Combustion.

    Skeen, Scott A.; Manin, Julien Luc; Pickett, Lyle M.


    The development of accurate predictive engine simulations requires experimental data to both inform and validate the models, but very limited information is presently available about the chemical structure of high pressure spray flames under engine- relevant conditions. Probing such flames for chemical information using non- intrusive optical methods or intrusive sampling techniques, however, is challenging because of the physical and optical harshness of the environment. This work details two new diagnostics that have been developed and deployed to obtain quantitative species concentrations and soot volume fractions from a high-pressure combusting spray. A high-speed, high-pressure sampling system was developed to extract gaseous species (including soot precursor species) from within the flame for offline analysis by time-of-flight mass spectrometry. A high-speed multi-wavelength optical extinction diagnostic was also developed to quantify transient and quasi-steady soot processes. High-pressure sampling and offline characterization of gas-phase species formed following the pre-burn event was accomplished as well as characterization of gas-phase species present in the lift-off region of a high-pressure n-dodecane spray flame. For the initial samples discussed in this work several species were identified, including polycyclic aromatic hydrocarbons (PAH); however, quantitative mole fractions were not determined. Nevertheless, the diagnostic developed here does have this capability. Quantitative, time-resolved measurements of soot extinction were also accomplished and the novel use of multiple incident wavelengths proved valuable toward characterizing changes in soot optical properties within different regions of the spray flame.

  6. Surface Diagnostics in Tribology Technology and Advanced Coatings Development

    Miyoshi, Kazuhisa


    This paper discusses the methodologies used for surface property measurement of thin films and coatings, lubricants, and materials in the field of tribology. Surface diagnostic techniques include scanning electron microscopy, transmission electron microscopy, atomic force microscopy, stylus profilometry, x-ray diffraction, electron diffraction, Raman spectroscopy, Rutherford backscattering, elastic recoil spectroscopy, and tribology examination. Each diagnostic technique provides specific measurement results in its own unique way. In due course it should be possible to coordinate the different pieces of information provided by these diagnostic techniques into a coherent self-consistent description of the surface properties. Examples are given on the nature and character of thin diamond films.

  7. Advancements in Research Synthesis Methods: From a Methodologically Inclusive Perspective

    Suri, Harsh; Clarke, David


    The dominant literature on research synthesis methods has positivist and neo-positivist origins. In recent years, the landscape of research synthesis methods has changed rapidly to become inclusive. This article highlights methodologically inclusive advancements in research synthesis methods. Attention is drawn to insights from interpretive,…

  8. Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges.

    Jeanes, Yvonne M; Reeves, Sue


    Women with polycystic ovary syndrome (PCOS) have a considerable risk of metabolic dysfunction. This review aims to present contemporary knowledge on obesity, insulin resistance and PCOS with emphasis on the diagnostic and methodological challenges encountered in research and clinical practice. Variable diagnostic criteria for PCOS and associated phenotypes are frequently published. Targeted searches were conducted to identify all available data concerning the association of obesity and insulin resistance with PCOS up to September 2016. Articles were considered if they were peer reviewed, in English and included women with PCOS. Obesity is more prevalent in women with PCOS, but studies rarely reported accurate assessments of adiposity, nor split the study population by PCOS phenotypes. Many women with PCOS have insulin resistance, though there is considerable variation reported in part due to not distinguishing subgroups known to have an impact on insulin resistance as well as limited methodology to measure insulin resistance. Inflammatory markers are positively correlated with androgen levels, but detailed interactions need to be identified. Weight management is the primary therapy; specific advice to reduce the glycaemic load of the diet and reduce the intake of pro-inflammatory SFA and advanced glycation endproducts have provided promising results. It is important that women with PCOS are educated about their increased risk of metabolic complications in order to make timely and appropriate lifestyle modifications. Furthermore, well-designed robust studies are needed to evaluate the mechanisms behind the improvements observed with dietary interventions.

  9. Current advances in diagnostic methods of Acanthamoeba keratitis

    Wang Yuehua; Feng Xianmin; Jiang Linzhe


    Objective The objective of this article was to review the current advances in diagnostic methods for Acanthamoeba keratitis (AK).Data sources Data used in this review were retrieved from PubMed (1970-2013).The terms "Acanthamoeba keratitis" and "diagnosis" were used for the literature search.Study selection Data from published articles regarding AK and diagnosis in clinical trials were identified and reviewed.Results The diagnostic methods for the eight species implicated in AK were reviewed.Among all diagnostic procedures,corneal scraping and smear examination was an essential diagnostic method.Polymerase chain reaction was the most sensitive and accurate detection method.Culturing of Acanthamoeba was a reliable method for final diagnosis of AK.Confocal microscopy to detect Acanthamoeba was also effective,without any invasive procedure,and was helpful in the early diagnosis of AK.Conclusion Clinically,conjunction of various diagnostic methods to diagnose AK was necessary.

  10. Diagnostic and therapeutic advancements for aerobic vaginitis.

    Han, Cha; Wu, Wenjuan; Fan, Aiping; Wang, Yingmei; Zhang, Huiying; Chu, Zanjun; Wang, Chen; Xue, Fengxia


    Aerobic vaginitis (AV) is a newly defined clinical entity that is distinct from candidiasis, trichomoniasis and bacterial vaginosis (BV). Because of the poor recognition of AV, this condition can lead to treatment failures and is associated with severe complications, such as pelvic inflammatory disease, infertility, preterm birth and foetal infections. This review describes the diagnosis and treatment of AV and the relationship between AV and pregnancy. The characteristics of AV include severely depressed levels of lactobacilli, increased levels of aerobic bacteria and an inflamed vagina. The diagnosis is made by microscopy on wet mounts of fresh vaginal fluid, and some distinct clinical features are recognized. Vaginal suppositories that contain kanamycin or clindamycin have shown curative effects in nonpregnant women. Additionally, the application of topical probiotics can restore the vaginal flora and reduce the recurrence of AV. Clindamycin vaginal suppositories and probiotics may be a better choice for gravida with AV than metronidazole. AV requires prompt attention, and the early diagnosis and treatment of AV during pregnancy significantly improves perinatal outcomes. Further research is needed to define the pathogenesis, diagnostic criteria and standard treatment guidelines for AV.

  11. A Hierarchical Statistic Methodology for Advanced Memory System Evaluation

    Sun, X.-J.; He, D.; Cameron, K.W.; Luo, Y.


    Advances in technology have resulted in a widening of the gap between computing speed and memory access time. Data access time has become increasingly important for computer system design. Various hierarchical memory architectures have been developed. The performance of these advanced memory systems, however, varies with applications and problem sizes. How to reach an optimal cost/performance design eludes researchers still. In this study, the authors introduce an evaluation methodology for advanced memory systems. This methodology is based on statistical factorial analysis and performance scalability analysis. It is two fold: it first determines the impact of memory systems and application programs toward overall performance; it also identifies the bottleneck in a memory hierarchy and provides cost/performance comparisons via scalability analysis. Different memory systems can be compared in terms of mean performance or scalability over a range of codes and problem sizes. Experimental testing has been performed extensively on the Department of Energy's Accelerated Strategic Computing Initiative (ASCI) machines and benchmarks available at the Los Alamos National Laboratory to validate this newly proposed methodology. Experimental and analytical results show this methodology is simple and effective. It is a practical tool for memory system evaluation and design. Its extension to general architectural evaluation and parallel computer systems are possible and should be further explored.

  12. Advances in paper-based point-of-care diagnostics.

    Hu, Jie; Wang, ShuQi; Wang, Lin; Li, Fei; Pingguan-Murphy, Belinda; Lu, Tian Jian; Xu, Feng


    Advanced diagnostic technologies, such as polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA), have been widely used in well-equipped laboratories. However, they are not affordable or accessible in resource-limited settings due to the lack of basic infrastructure and/or trained operators. Paper-based diagnostic technologies are affordable, user-friendly, rapid, robust, and scalable for manufacturing, thus holding great potential to deliver point-of-care (POC) diagnostics to resource-limited settings. In this review, we present the working principles and reaction mechanism of paper-based diagnostics, including dipstick assays, lateral flow assays (LFAs), and microfluidic paper-based analytical devices (μPADs), as well as the selection of substrates and fabrication methods. Further, we report the advances in improving detection sensitivity, quantification readout, procedure simplification and multi-functionalization of paper-based diagnostics, and discuss the disadvantages of paper-based diagnostics. We envision that miniaturized and integrated paper-based diagnostic devices with the sample-in-answer-out capability will meet the diverse requirements for diagnosis and treatment monitoring at the POC.

  13. Ehrlichia: Advances in vaccines, diagnostics and pathobiology

    Jere W McBride


    Full Text Available Ehrlichia spp. is responsible emerging human zoonoses and diseases of veterinary importance in the Americas. Ehrlichia chaffeensis emerged in North America in 1986 and new Ehrlichia spp. associated with human disease continue to emerge with the recent identification of an E. muris-like agent in Minnesota and Wisconsin in 2011. E. canis is prevalent throughout the Americas in dogs and has been associated with human disease in South America. The human ehrlichioses caused by all these erlichias together with E. ewingii, is an important public health problem. In the last years have been important advanced in vaccine development, immunodiagnostic and pathobiology of these diseases. However, is necessary the understanding of disease mechanisms of these emerging tick-transmitted pathogens in human and veterinary medicine.

  14. A Methodology for Anatomic Ultrasound Image Diagnostic Quality Assessment

    Hemmsen, Martin Christian; Lange, Theis; Brandt, Andreas Hjelm


    is valuable in the continuing process of method optimization and guided development of new imaging methods. It includes a three phased study plan covering from initial prototype development to clinical assessment. Recommendations to the clinical assessment protocol, software, and statistical analysis......This paper discusses methods for assessment of ultrasound image quality based on our experiences with evaluating new methods for anatomic imaging. It presents a methodology to ensure a fair assessment between competing imaging methods using clinically relevant evaluations. The methodology...... to properly reveal the clinical value. The paper exemplifies the methodology using recent studies of Synthetic Aperture Sequential Beamforming tissue harmonic imaging....

  15. Diagnostics for advanced laser acceleration experiments

    Misuri, Alessio [Univ. of Pisa (Italy)


    The first proposal for plasma based accelerators was suggested by 1979 by Tajima and Dawson. Since then there has been a tremendous progress both theoretically and experimentally. The theoretical progress is particularly due to the growing interest in the subject and to the development of more accurate numerical codes for the plasma simulations (especially particle-in-cell codes). The experimental progress follows from the development of multi-terawatt laser systems based on the chirped-pulse amplification technique. These efforts have produced results in several experiments world-wide, with the detection of accelerated electrons of tens of MeV. The peculiarity of these advanced accelerators is their ability to sustain extremely large acceleration gradients. In the conventional radio frequency linear accelerators (RF linacs) the acceleration gradients are limited roughly to 100 MV/m; this is partially due to breakdown which occurs on the walls of the structure. The electrical breakdown is originated by the emission of the electrons from the walls of the cavity. The electrons cause an avalanche breakdown when they reach other metal parts of the RF linacs structure.

  16. Diagnostics for advanced laser acceleration experiments

    Misuri, Alessio


    The first proposal for plasma based accelerators was suggested by 1979 by Tajima and Dawson. Since then there has been a tremendous progress both theoretically and experimentally. The theoretical progress is particularly due to the growing interest in the subject and to the development of more accurate numerical codes for the plasma simulations (especially particle-in-cell codes). The experimental progress follows from the development of multi-terawatt laser systems based on the chirped-pulse amplification technique. These efforts have produced results in several experiments world-wide, with the detection of accelerated electrons of tens of MeV. The peculiarity of these advanced accelerators is their ability to sustain extremely large acceleration gradients. In the conventional radio frequency linear accelerators (RF linacs) the acceleration gradients are limited roughly to 100 MV/m; this is partially due to breakdown which occurs on the walls of the structure. The electrical breakdown is originated by the emission of the electrons from the walls of the cavity. The electrons cause an avalanche breakdown when they reach other metal parts of the RF linacs structure.

  17. A Methodology for Anatomic Ultrasound Image Diagnostic Quality Assessment.

    Hemmsen, Martin Christian; Lange, Theis; Brandt, Andreas Hjelm; Nielsen, Michael Bachmann; Jensen, Jorgen Arendt


    This paper discusses the methods for the assessment of ultrasound image quality based on our experiences with evaluating new methods for anatomic imaging. It presents a methodology to ensure a fair assessment between competing imaging methods using clinically relevant evaluations. The methodology is valuable in the continuing process of method optimization and guided development of new imaging methods. It includes a three phased study plan covering from initial prototype development to clinical assessment. Recommendations to the clinical assessment protocol, software, and statistical analysis are presented. Earlier uses of the methodology has shown that it ensures validity of the assessment, as it separates the influences between developer, investigator, and assessor once a research protocol has been established. This separation reduces confounding influences on the result from the developer to properly reveal the clinical value. This paper exemplifies the methodology using recent studies of synthetic aperture sequential beamforming tissue harmonic imaging.

  18. Methodology for design of adaptive interfaces for diagnostic workstations with integrated images and reports

    Harreld, Michael R.; Valentino, Daniel J.; Liu, Brent J.; El-Saden, Suzie; Duckwiler, Gary R.


    Diagnostic workstations have generally lacked acceptance due to awkward interfaces, poor usability and lack of clinical data integration. We developed a new methodology for the design and implementation of diagnostic workstations and applied the methodology in diagnostic neuroradiology. The methodology facilitated the objective design and evaluation of optimal diagnostic features, including the integration of images and reports, and the implementation of intelligent and adaptive graphical user interfaces. As a test of this new methodology, we developed and evaluated a neuroradiological diagnostic workstation. The general goals of diagnostic neuroradiologists were modeled and directly used in the design of the UCLA Digital ViewBox, an object-oriented toolkit for medical imaging workstations. For case-specific goals, an object-oriented protocol toolkit was developed for rapid development and integration of new protocols, modes, and tools. Each protocol defines a way to arrange and process data in order to accomplish diagnostic goals that are specific to anatomy (e.g., a spine protocol), or to a suspected pathology (e.g., a tumor protocol). Each protocol was divided into modes that represent diagnostic reading tasks. Each mode was further broken down into functions supporting that task. Via a data mediator engine, the workstation communicated with clinical data repositories, including the UCLA HIS, Clinical RIS/PACS and individual DICOM compatible scanners. The data mediator served to transparently integrate, retrieve, and cache image and report data. Task-oriented Reading protocols automatically present the appropriate diagnostic information and diagnostic tools to the radiologist. We describe a protocol toolkit that enables the rapid design and implementation of customized reading protocols. We also present an intelligent layer that enables the automatic presentation of the appropriate information. This new methodology for diagnostic workstation design led to an

  19. Pedagogical diagnostics in preschool organization: regulatory and methodological support for the implementation

    Liliya Sannikova


    Full Text Available The materials of the article presents an analysis of the provisions of the normative and methodological documents regulating the use of pedagogical diagnostics in preschool educational institution

  20. Have Cognitive Diagnostic Models Delivered Their Goods? Some Substantial and Methodological Concerns

    Wilhelm, Oliver; Robitzsch, Alexander


    The paper by Rupp and Templin (2008) is an excellent work on the characteristics and features of cognitive diagnostic models (CDM). In this article, the authors comment on some substantial and methodological aspects of this focus paper. They organize their comments by going through issues associated with the terms "cognitive," "diagnostic" and…

  1. BOOK REVIEW: Advanced Diagnostics for Magnetic and Inertial Confinement Fusion

    Stott, PE; Wootton, A.; Gorini, G.; Sindoni, E.; Batani, D.


    This book is a collection of papers, written by specialists in the field, on advanced topics of nuclear fusion diagnostics. The 78 contributions were originally presented at the International Conference on Advanced Diagnostics for Magnetic and Inertial Fusion held at Villa Monastero, Italy in September 2001. Both magnetically confined and inertial fusion programmes are quite extensively covered, with more emphasis given to the former scheme. In the case of magnetic confinement, since the present international programme is strongly focused on next-step devices, particular attention is devoted to techniques and technologies viable in an environment with strong neutron fluxes. Indeed, in the first section, the various methods are considered in the perspective of performing the measurements of the relevant parameters in conditions approaching a burning plasma, mainly in the Tokamak configuration. The most demanding requirements, like the implications of the use of tritium and radiation resistance, are reviewed and the most challenging open issues, which require further research and development, are also clearly mentioned. The following three sections are devoted to some of the most recent developments in plasma diagnostics, which are grouped according to the following classification: `Neutron and particle diagnostics', `Optical and x-ray diagnostics' and `Interferometry, Polarimetry and Thomson Scattering'. In these chapters, several of the most recent results are given, covering measurements taken on the most advanced experiments around the world. Here the developments described deal more with the requirements imposed by the physical issues to be studied. They are therefore more focused on the approaches adopted to increase the spatial and time resolution of the diagnostics, on some methods to improve the characterisation of the turbulence and on fast particles. Good coverage is given to neutron diagnostics, which are assuming increasing relevance as the plasma

  2. Application of Six Sigma methodology to a diagnostic imaging process.

    Taner, Mehmet Tolga; Sezen, Bulent; Atwat, Kamal M


    This paper aims to apply the Six Sigma methodology to improve workflow by eliminating the causes of failure in the medical imaging department of a private Turkish hospital. Implementation of the design, measure, analyse, improve and control (DMAIC) improvement cycle, workflow chart, fishbone diagrams and Pareto charts were employed, together with rigorous data collection in the department. The identification of root causes of repeat sessions and delays was followed by failure, mode and effect analysis, hazard analysis and decision tree analysis. The most frequent causes of failure were malfunction of the RIS/PACS system and improper positioning of patients. Subsequent to extensive training of professionals, the sigma level was increased from 3.5 to 4.2. The data were collected over only four months. Six Sigma's data measurement and process improvement methodology is the impetus for health care organisations to rethink their workflow and reduce malpractice. It involves measuring, recording and reporting data on a regular basis. This enables the administration to monitor workflow continuously. The improvements in the workflow under study, made by determining the failures and potential risks associated with radiologic care, will have a positive impact on society in terms of patient safety. Having eliminated repeat examinations, the risk of being exposed to more radiation was also minimised. This paper supports the need to apply Six Sigma and present an evaluation of the process in an imaging department.

  3. Synergistic advances in diagnostic and therapeutic medical ultrasound

    Lizzi, Frederic L.


    Significant advances are more fully exploiting ultrasound's potential for noninvasive diagnosis and treatment. Therapeutic systems employ intense focused beams to thermally kill cancer cells in, e.g., prostate; to stop bleeding; and to treat specific diseases (e.g., glaucoma). Diagnostic ultrasound techniques can quantitatively image an increasingly broad spectrum of physical tissue attributes. An exciting aspect of this progress is the emerging synergy between these modalities. Advanced diagnostic techniques may contribute at several stages in therapy. For example, treatment planning for small ocular tumors uses 50-MHz, 3-D ultrasonic images with 0.05-mm resolution. Thermal simulations employ these images to evaluate desired and undesired effects using exposure stategies with specially designed treatment beams. Therapy beam positioning can use diagnostic elastography to sense tissue motion induced by radiation pressure from high-intensity treatment beams. Therapy monitoring can sense lesion formation using elastography motion sensing (to detect the increased stiffness in lesions); harmonic imaging (to sense altered nonlinear properties); and spectrum analysis images (depicting changes in the sizes, concentration, and configuration of sub-resolution structures.) Experience from these applications will greatly expand the knowledge of acoustic phenomena in living tissues and should lead to further advances in medical ultrasound.

  4. Measurement of backscatter factor for diagnostic radiology: methodology and uncertainties

    Rosado, P.H.G.; Nogueira, M.D.S.; Squair, P.L.; Da Silva, T.A. [Centro de Desenvolvimento da Tecnoogia Nuclear (CDTN/CNEN) 30123-970, Minas Gerais (Brazil)]. e-mail:


    Full text: Backscatter factors were experimentally determined for the diagnostic X-ray qualities recommended by the International Electrotechnical Commission (IEC) for primary beams (RQR). Harshaw LiF-1 100H thermoluminescent dosemeters used for determining the backscatter were calibrated against an ionization chamber traceable to the National Metrology Laboratory. A 300mm x 300mm x 150mm PMMA slab phantom was used for deep-doses measurements. To perform the in-phantom measurements, the dosemeters were placed in the central axis of the x-ray beam at five different depths d in the phantom (5, 10, 15, 25 and 35 mm) upstream the beam direction. The typical combined standard uncertainty of the backscatter factor value was 6%. The main sources of uncertainties were the calibration procedure, the TLD dosimetry and the use of deep-dose curves. (Author)

  5. Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities.

    McNerney, Ruth; Maeurer, Markus; Abubakar, Ibrahim; Marais, Ben; McHugh, Timothy D; Ford, Nathan; Weyer, Karin; Lawn, Steve; Grobusch, Martin P; Memish, Ziad; Squire, S Bertel; Pantaleo, Giuseppe; Chakaya, Jeremiah; Casenghi, Martina; Migliori, Giovanni-Batista; Mwaba, Peter; Zijenah, Lynn; Hoelscher, Michael; Cox, Helen; Swaminathan, Soumya; Kim, Peter S; Schito, Marco; Harari, Alexandre; Bates, Matthew; Schwank, Samana; O'Grady, Justin; Pletschette, Michel; Ditui, Lucica; Atun, Rifat; Zumla, Alimuddin


    Tuberculosis is unique among the major infectious diseases in that it lacks accurate rapid point-of-care diagnostic tests. Failure to control the spread of tuberculosis is largely due to our inability to detect and treat all infectious cases of pulmonary tuberculosis in a timely fashion, allowing continued Mycobacterium tuberculosis transmission within communities. Currently recommended gold-standard diagnostic tests for tuberculosis are laboratory based, and multiple investigations may be necessary over a period of weeks or months before a diagnosis is made. Several new diagnostic tests have recently become available for detecting active tuberculosis disease, screening for latent M. tuberculosis infection, and identifying drug-resistant strains of M. tuberculosis. However, progress toward a robust point-of-care test has been limited, and novel biomarker discovery remains challenging. In the absence of effective prevention strategies, high rates of early case detection and subsequent cure are required for global tuberculosis control. Early case detection is dependent on test accuracy, accessibility, cost, and complexity, but also depends on the political will and funder investment to deliver optimal, sustainable care to those worst affected by the tuberculosis and human immunodeficiency virus epidemics. This review highlights unanswered questions, challenges, recent advances, unresolved operational and technical issues, needs, and opportunities related to tuberculosis diagnostics.

  6. Undulator A diagnostics at the Advanced Photon Source

    Ilinski, P.


    Diagnostics of Undulator A{number_sign}2 (UA2) radiation was performed during the October 1997 mn at the Advanced Photon Source (APS). The UA2 undulator is a standard 3.3-cm-period APS Undulator A, which was positioned downstream from the center of the straight section at Sector 8. The diagnostics included the angular-spectral measurements of the undulator radiation to determine the undulator radiation absolute spectral flux and the particle beam divergence. The results of the absolute spectral flux measurements are compared to the undulator spectrum calculated from measured undulator magnetic field. The particle`s energy spread was determined from spectra comparison. Previously, the authors reported the first measurements made on Undulator A at the APS. The purpose of the present report is to summarize the results of the diagnostics performed on the Sector 8 undulator at the request of the IMM-CAT staff, and to present a more general discussion of undulator radiation sources at the APS and details of their diagnostics.

  7. Advanced monitoring, fault diagnostics, and maintenance of cryogenic systems

    Girone, Mario; Pezzetti, Marco

    In this Thesis, advanced methods and techniques of monitoring, fault diagnostics, and predictive maintenance for cryogenic processes and systems are described. In particular, in Chapter 1, mainstreams in research on measurement systems for cryogenic processes are reviewed with the aim of dening key current trends and possible future evolutions. Then, in Chapter 2, several innovative methods are proposed. A transducer based on a virtual ow meter is presented for monitoring helium distribution and consumption in cryogenic systems for particle accelerators [1]. Furthermore, a comprehensive metrological analysis of the proposed transducer for verifying the metrological performance and pointing out most critical uncertainty sources is described [2]. A model-based method for fault detection and early-stage isolation, able to work with few records of Frequency Response Function (FRF) on an unfaulty compressor, is then proposed [3]. To enrich the proposal, a distributed diagnostic procedure, based on a micro-genetic...

  8. Halo current diagnostic system of experimental advanced superconducting tokamak

    Chen, D. L.; Shen, B.; Sun, Y.; Qian, J. P., E-mail:; Wang, Y.; Xiao, B. J. [Institute of Plasma Physics, Chinese Academy of Sciences, P.O. Box 1126, Hefei 230031 (China); Granetz, R. S. [MIT Plasma Science and Fusion Center, Cambridge, Massachusetts 02139 (United States)


    The design, calibration, and installation of disruption halo current sensors for the Experimental Advanced Superconducting Tokamak are described in this article. All the sensors are Rogowski coils that surround conducting structures, and all the signals are analog integrated. Coils with two different cross-section sizes have been fabricated, and their mutual inductances are calibrated. Sensors have been installed to measure halo currents in several different parts of both the upper divertor (tungsten) and lower divertor (graphite) at several toroidal locations. Initial measurements from disruptions show that the halo current diagnostics are working well.

  9. Halo current diagnostic system of experimental advanced superconducting tokamak

    Chen, D. L.; Shen, B.; Granetz, R. S.; Sun, Y.; Qian, J. P.; Wang, Y.; Xiao, B. J.


    The design, calibration, and installation of disruption halo current sensors for the Experimental Advanced Superconducting Tokamak are described in this article. All the sensors are Rogowski coils that surround conducting structures, and all the signals are analog integrated. Coils with two different cross-section sizes have been fabricated, and their mutual inductances are calibrated. Sensors have been installed to measure halo currents in several different parts of both the upper divertor (tungsten) and lower divertor (graphite) at several toroidal locations. Initial measurements from disruptions show that the halo current diagnostics are working well.

  10. Methodological advances in drug discovery for Chagas disease

    Bustamante, Juan M.; Tarleton, Rick L.


    Introduction Chagas disease is the highest impact human infectious disease in Latin America, and the leading worldwide cause of myocarditis. Despite the availability of several compounds that have demonstrated efficacy in limiting the effects of T. cruzi, these compounds are rarely used due to their variable efficacy, substantial side effects and the lack of methodologies for confirming their effectiveness. Furthermore, the development of more efficacious compounds is challenged by limitations of systems for assessing drug efficacy in vitro and in vivo. Areas covered Herein, the authors review the development of Chagas disease drug discovery methodology, focusing on recent developments in high throughput screening, in vivo testing methods and assessments of efficacy in humans. Particularly, this review documents the significant progress that has taken place over the last 5 years that have paved the way for both target-focused and high-throughput screens of compound libraries. Expert opinion The tools for in vitro and in vivo screening of anti-T. cruzi compounds have improved dramatically in the last few years and there are now a number of excellent in vivo testing models available; this somewhat alleviates the bottleneck issue of quickly and definitively demonstrating in vivo efficacy in a relevant host animal system. These advances emphasize the potential for additional progress resulting in new treatments for Chagas disease in the coming years. That being said, national and international agencies must improve the coordination of research and development efforts in addition to cultivating the funding sources for the development of these new treatments. PMID:21712965

  11. Advanced Fuel Cycle Economic Tools, Algorithms, and Methodologies

    David E. Shropshire


    The Advanced Fuel Cycle Initiative (AFCI) Systems Analysis supports engineering economic analyses and trade-studies, and requires a requisite reference cost basis to support adequate analysis rigor. In this regard, the AFCI program has created a reference set of economic documentation. The documentation consists of the “Advanced Fuel Cycle (AFC) Cost Basis” report (Shropshire, et al. 2007), “AFCI Economic Analysis” report, and the “AFCI Economic Tools, Algorithms, and Methodologies Report.” Together, these documents provide the reference cost basis, cost modeling basis, and methodologies needed to support AFCI economic analysis. The application of the reference cost data in the cost and econometric systems analysis models will be supported by this report. These methodologies include: the energy/environment/economic evaluation of nuclear technology penetration in the energy market—domestic and internationally—and impacts on AFCI facility deployment, uranium resource modeling to inform the front-end fuel cycle costs, facility first-of-a-kind to nth-of-a-kind learning with application to deployment of AFCI facilities, cost tradeoffs to meet nuclear non-proliferation requirements, and international nuclear facility supply/demand analysis. The economic analysis will be performed using two cost models. VISION.ECON will be used to evaluate and compare costs under dynamic conditions, consistent with the cases and analysis performed by the AFCI Systems Analysis team. Generation IV Excel Calculations of Nuclear Systems (G4-ECONS) will provide static (snapshot-in-time) cost analysis and will provide a check on the dynamic results. In future analysis, additional AFCI measures may be developed to show the value of AFCI in closing the fuel cycle. Comparisons can show AFCI in terms of reduced global proliferation (e.g., reduction in enrichment), greater sustainability through preservation of a natural resource (e.g., reduction in uranium ore depletion), value from

  12. Diagnostic imaging advances in murine models of colitis.

    Brückner, Markus; Lenz, Philipp; Mücke, Marcus M; Gohar, Faekah; Willeke, Peter; Domagk, Dirk; Bettenworth, Dominik


    Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis are chronic-remittent inflammatory disorders of the gastrointestinal tract still evoking challenging clinical diagnostic and therapeutic situations. Murine models of experimental colitis are a vital component of research into human IBD concerning questions of its complex pathogenesis or the evaluation of potential new drugs. To monitor the course of colitis, to the present day, classical parameters like histological tissue alterations or analysis of mucosal cytokine/chemokine expression often require euthanasia of animals. Recent advances mean revolutionary non-invasive imaging techniques for in vivo murine colitis diagnostics are increasingly available. These novel and emerging imaging techniques not only allow direct visualization of intestinal inflammation, but also enable molecular imaging and targeting of specific alterations of the inflamed murine mucosa. For the first time, in vivo imaging techniques allow for longitudinal examinations and evaluation of intra-individual therapeutic response. This review discusses the latest developments in the different fields of ultrasound, molecularly targeted contrast agent ultrasound, fluorescence endoscopy, confocal laser endomicroscopy as well as tomographic imaging with magnetic resonance imaging, computed tomography and fluorescence-mediated tomography, discussing their individual limitations and potential future diagnostic applications in the management of human patients with IBD.

  13. Advanced studies on Simulation Methodologies for very Complicated Fracture Phenomena

    Nishioka, Toshihisa


    Although nowadays, computational techniques are well developed, for Extremely Complicated Fracture Phenomena, they are still very difficult to simulate, for general engineers, researchers. To overcome many difficulties in those simulations, we have developed not only Simulation Methodologies but also theoretical basis and concepts. We sometimes observe extremely complicated fracture patterns, especially in dynamic fracture phenomena such as dynamic crack branching, kinking, curving, etc. For examples, although the humankind, from primitive men to modern scientists such as Albert Einstein had watched the post-mortem patterns of dynamic crack branching, the governing condition for the onset of the phenomena had been unsolved until our experimental study. From in these studies, we found the governing condition of dynamic crack bifurcation, as follows. When the total energy flux per unit time into a propagating crack tip reaches the material crack resistance, the crack braches into two cracks [total energy flux criterion]. The crack branches many times whenever the criterion is satisfied. Furthermore, the complexities also arise due to their time-dependence and/or their-deformation dependence. In order to make it possible to simulate such extremely complicated fracture phenomena, we developed many original advanced computational methods and technologies. These are (i)moving finite element method based on Delaunay automatic triangulation (MFEMBOAT), path independent,(ii) equivalent domain integral expression of the dynamic J integral associated with a continuous auxiliary function,(iii) Mixed phase path-prediction mode simulation, (iv) implicit path prediction criterion. In this paper, these advanced computational methods are thoroughly explained together with successful comparison with the experimental results. Since multiple dynamic crack branching phenomena may be most complicated fracture due to complicated fracture paths, and its time dependence (transient), this

  14. Advanced methodology for generation expansion planning including interconnected systems

    Zhao, M.; Yokoyama, R.; Yasuda, K. [Tokyo Metropolitan Univ. (Japan); Sasaki, H. [Hiroshima Univ. (Japan); Ogimoto, K. [Electric Power Development Co. Ltd., Tokyo (Japan)


    This paper reviews advanced methodology for generation expansion planning including interconnected systems developed in Japan, putting focus on flexibility and efficiency in a practical application. First, criteria for evaluating flexibility of generation planning considering uncertainties are introduced. Secondly, the flexible generation mix problem is formulated as a multi-objective optimization with more than two objective functions. The multi-objective optimization problem is then transformed into a single objective problem by using the weighting method, to obtain the Pareto optimal solution, and solved by a dynamics programming technique. Thirdly, a new approach for electric generation expansion planning of interconnected systems is presented, based on the Benders Decomposition technique. That is, large scale generation problem constituted by the general economic load dispatch problem, and several sub problems which are composed of smaller scale isolated system generation expansion plans. Finally, the generation expansion plan solved by an artificial neural network is presented. In conclusion, the advantages and disadvantages of this method from the viewpoint of flexibility and applicability to practical generation expansion planning are presented. (author) 29 refs., 10 figs., 4 tabs.

  15. CARDIOGRAMA: a stochastic, semi-empirical methodology for power-reactor surveillance and diagnostics

    March-Leuba, J.A.; deSaussure, G.; Perez, R.B.


    The utilization of stochastic methods (reactor noise) for power reactor diagnostics and surveillance applications is by now a relatively well-established technique. In this technique, the power spectral density (PSD) of the fluctuations of a specified state variable is often used to define the reactor's signature at a given configuration. The purpose of the present work is to address the problem of handling efficiently the substantial amount of information involved in the application of reactor surveillance and diagnostics methods. Specifically, a methodology is described for: (a) representing the PSDs parametrically, and (b) detecting changes from the reactor's baseline PSD (normal signature).

  16. Advanced quantitative measurement methodology in physics education research

    Wang, Jing

    reasoning ability structures for U.S. and Chinese students at different educational levels are given by the analysis. A final discussion on the advanced quantitative assessment methodology and the pure mathematical methodology is presented at the end.

  17. Human toxocariasis: current advances in diagnostics, treatment, and interventions.

    Moreira, Gustavo Marçal Schmidt Garcia; Telmo, Paula de Lima; Mendonça, Marcelo; Moreira, Angela Nunes; McBride, Alan John Alexander; Scaini, Carlos James; Conceição, Fabricio Rochedo


    Toxocariasis is a neglected zoonosis caused by the nematodes Toxocara canis and Toxocara cati. This disease is widespread in many countries, reaching high prevalence independently of the economic conditions. However, the true number of cases of toxocariasis is likely to be underestimated owing to the lack of adequate surveillance programs. Although some diagnostic tests are available, their sensitivity and specificity need to be improved. In addition, treatment options for toxocariasis are limited and are non-specific. Toxocariasis is listed as one of the five most important neglected diseases by the CDC. This review presents recent advances related to the control of toxocariasis, including new immunodiagnostics, therapies, and drug formulations, as well as novel interventions using DNA vaccines, immunomodulators, and probiotics.

  18. Advanced targets, diagnostics and applications of laser-generated plasmas

    Torrisi, L.


    High-intensity sub-nanosecond-pulsed lasers irradiating thin targets in vacuum permit generation of electrons and ion acceleration and high photon yield emission in non-equilibrium plasmas. At intensities higher than 1015 W/cm2 thin foils can be irradiated in the target-normal sheath acceleration regime driving ion acceleration in the forward direction above 1 MeV per charge state. The distributions of emitted ions in terms of energy, charge state and angular emission are controlled by laser parameters, irradiation conditions, target geometry and composition. Advanced targets can be employed to increase the laser absorption in thin foils and to enhance the energy and the yield of the ion acceleration process. Semiconductor detectors, Thomson parabola spectrometer and streak camera can be employed as online plasma diagnostics to monitor the plasma parameters, shot by shot. Some applications in the field of the multiple ion implantation, hadrontherapy and nuclear physics are reported.

  19. Charged-particle beam diagnostics for the advanced photon source

    Lumpkin, A. H.; Decker, G.; Kahana, E.; Patterson, D.; Sellyey, W.; Wang, X.; Chung, Y.


    Plans, prototypes, and initial test results for the charged-particle beam (e -, e +) diagnostic systems on the injector rings, their transport lines, and the storage ring for the Advanced Photon Source (APS) are presented. The APS will be a synchrotron radiation user facility with one of the world's brightest X-ray sources in the 10-keV regime. Its 200-MeV electron linac, 450-MeV positron linac, positron accumulator ring, 7-GeV injector synchrotron (IS), 7-GeV storage ring (SR), and undulator test lines will also demand the development and demonstration of key particle-beam characterization techniques over a wide range of parameter space. Some of these parameter values overlap or approach those projected for fourth generation light sources (linac-driven FELs and high brightness storage rings) as described at a recent workshop. Initial results from the diagnostics prototypes on the linac test stand operating at 45-MeV include current monitor data, beam loss monitor data, and video digitization using VME architecture.

  20. Advanced tomographic flow diagnostics for opaque multiphase fluids

    Torczynski, J.R.; O`Hern, T.J.; Adkins, D.R.; Jackson, N.B.; Shollenberger, K.A.


    This report documents the work performed for the ``Advanced Tomographic Flow Diagnostics for Opaque Multiphase Fluids`` LDRD (Laboratory-Directed Research and Development) project and is presented as the fulfillment of the LDRD reporting requirement. Dispersed multiphase flows, particularly gas-liquid flows, are industrially important to the chemical and applied-energy industries, where bubble-column reactors are employed for chemical synthesis and waste treatment. Due to the large range of length scales (10{sup {minus}6}-10{sup 1}m) inherent in real systems, direct numerical simulation is not possible at present, so computational simulations are forced to use models of subgrid-scale processes, the accuracy of which strongly impacts simulation fidelity. The development and validation of such subgrid-scale models requires data sets at representative conditions. The ideal measurement techniques would provide spatially and temporally resolved full-field measurements of the distributions of all phases, their velocity fields, and additional associated quantities such as pressure and temperature. No technique or set of techniques is known that satisfies this requirement. In this study, efforts are focused on characterizing the spatial distribution of the phases in two-phase gas-liquid flow and in three-phase gas-liquid-solid flow. Due to its industrial importance, the bubble-column geometry is selected for diagnostics development and assessment. Two bubble-column testbeds are utilized: one at laboratory scale and one close to industrial scale. Several techniques for measuring the phase distributions at conditions of industrial interest are examined: level-rise measurements, differential-pressure measurements, bulk electrical impedance measurements, electrical bubble probes, x-ray tomography, gamma-densitometry tomography, and electrical impedance tomography.

  1. Animal Models of Virus-Induced Neurobehavioral Sequelae: Recent Advances, Methodological Issues, and Future Prospects

    Marco Bortolato


    Full Text Available Converging lines of clinical and epidemiological evidence suggest that viral infections in early developmental stages may be a causal factor in neuropsychiatric disorders such as schizophrenia, bipolar disorder, and autism-spectrum disorders. This etiological link, however, remains controversial in view of the lack of consistent and reproducible associations between viruses and mental illness. Animal models of virus-induced neurobehavioral disturbances afford powerful tools to test etiological hypotheses and explore pathophysiological mechanisms. Prenatal or neonatal inoculations of neurotropic agents (such as herpes-, influenza-, and retroviruses in rodents result in a broad spectrum of long-term alterations reminiscent of psychiatric abnormalities. Nevertheless, the complexity of these sequelae often poses methodological and interpretational challenges and thwarts their characterization. The recent conceptual advancements in psychiatric nosology and behavioral science may help determine new heuristic criteria to enhance the translational value of these models. A particularly critical issue is the identification of intermediate phenotypes, defined as quantifiable factors representing single neurochemical, neuropsychological, or neuroanatomical aspects of a diagnostic category. In this paper, we examine how the employment of these novel concepts may lead to new methodological refinements in the study of virus-induced neurobehavioral sequelae through animal models.

  2. 39{sup th} Annual meeting of the European Society of Neuroradiology. Diagnostic and interventional. 23{sup rd} Advanced course in diagnostic neuroradiology and 8{sup th} advanced course in interventional neuroradiology. ESNR 2016



    The volume includes contributions to the 39{sup th} annual meeting of the European Society of Neuroradiology, the 23{sup rd} advanced course in diagnostic neuroradiology and the 8{sup th} advanced course in interventional neuroradiology. The following issues are covered: advanced diagnostic course tumor imaging, advanced course on stroke management; diagnostic brain, interventional, head and neck, spine.

  3. Development of advanced strain diagnostic techniques for reactor environments.

    Fleming, Darryn D.; Holschuh, Thomas Vernon,; Miller, Timothy J.; Hall, Aaron Christopher; Urrea, David Anthony,; Parma, Edward J.,


    The following research is operated as a Laboratory Directed Research and Development (LDRD) initiative at Sandia National Laboratories. The long-term goals of the program include sophisticated diagnostics of advanced fuels testing for nuclear reactors for the Department of Energy (DOE) Gen IV program, with the future capability to provide real-time measurement of strain in fuel rod cladding during operation in situ at any research or power reactor in the United States. By quantifying the stress and strain in fuel rods, it is possible to significantly improve fuel rod design, and consequently, to improve the performance and lifetime of the cladding. During the past year of this program, two sets of experiments were performed: small-scale tests to ensure reliability of the gages, and reactor pulse experiments involving the most viable samples in the Annulated Core Research Reactor (ACRR), located onsite at Sandia. Strain measurement techniques that can provide useful data in the extreme environment of a nuclear reactor core are needed to characterize nuclear fuel rods. This report documents the progression of solutions to this issue that were explored for feasibility in FY12 at Sandia National Laboratories, Albuquerque, NM.

  4. A Diagnostic Model for Dementia in Clinical Practice-Case Methodology Assisting Dementia Diagnosis.

    Londos, Elisabet


    Dementia diagnosis is important for many different reasons. Firstly, to separate dementia, or major neurocognitive disorder, from MCI (mild cognitive impairment), mild neurocognitive disorder. Secondly, to define the specific underlying brain disorder to aid treatment, prognosis and decisions regarding care needs and assistance. The diagnostic method of dementias is a puzzle of different data pieces to be fitted together in the best possible way to reach a clinical diagnosis. Using a modified case methodology concept, risk factors affecting cognitive reserve and symptoms constituting the basis of the brain damage hypothesis, can be visualized, balanced and reflected against test results as well as structural and biochemical markers. The model's origin is the case method initially described in Harvard business school, here modified to serve dementia diagnostics.

  5. Uptake of newer methodological developments and the deployment of meta-analysis in diagnostic test research: a systematic review

    Quigley Muireann; Willis Brian H


    Abstract Background The last decade has seen a number of methodological developments in meta-analysis of diagnostic test studies. However, it is unclear whether such developments have permeated the wider research community and on which applications they are being deployed. The objective was to assess the uptake and deployment of the main methodological developments in the meta-analysis of diagnostic tests, and identify the tests and target disorders most commonly evaluated by meta-analysis. M...

  6. Advanced chemistry of monolayers at interfaces trends in methodology and technology

    Imae, Toyoko


    Advanced Chemistry of Monolayers at Interfaces describes the advanced chemistry of monolayers at interfaces. Focusing on the recent trends of methodology and technology, which are indispensable in monolayer science. They are applied to monolayers of surfactants, amphiphiles, polymers, dendrimers, enzymes, and proteins, which serve many uses.Introduces the methodologies of scanning probe microscopy, surface force instrumentation, surface spectroscopy, surface plasmon optics, reflectometry, and near-field scanning optical microscopy. Modern interface reaction method, lithographic tech

  7. Advanced diagnostics in oxy-fuel combustion processes

    Brix, J.; Clausen, Soennik; Degn Jensen, A. (Technical Univ. of Denmark. CHEC Research Centre, Kgs. Lyngby (Denmark)); Boeg Toftegaard, M. (DONG Energy Power, Hvidovre (Denmark))


    This report sums up the findings in PSO-project 010069, ''Advanced Diagnostics in Oxy-Fuel Combustion Processes''. Three areas of optic diagnostics are covered in this work: - FTIR measurements in a 30 kW swirl burner. - IR measurements in a 30 kW swirl burner. - IR measurements in a laboratory scale fixed bed reactor. The results obtained in the swirl burner have proved the FTIR method as a valuable technique for gas phase temperature measurements. When its efficacy is evaluated against traditional thermocouple measurements, two cases, with and without probe beam stop, must however be treated separately. When the FTIR probe is operated with the purpose of gas phase concentration measurements the probe needs to operate with a beam stop mounted in front of it. With this beam stop in place it was shown that the measured gas phase temperature was affected by cooling, induced by the cooled beam stop. Hence, for a more accurate determination of gas phase temperatures the probe needed to operate without the beam stop. When this was the case, the FTIR probe showed superior to traditional temperature measurements using a thermocouple as it could measure the fast temperature fluctuations. With the beam stop in place the efficacy of the FTIR probe for gas temperature determination was comparable to the use of a traditional thermocouple. The evaluation of the FTIR technique regarding estimation of gas phase concentrations of H{sub 2}O, CO{sub 2} and CO showed that the method is reliable though it cannot be stated as particularly accurate. The accuracy of the method is dependent on the similarity of the reference emission spectra of the gases with those obtained in the experiments, as the transmittance intensity is not a linear function of concentration. The length of the optical path also affects the steadiness of the measurements. The length of the optical path is difficult to adjust on the small scales that are the focus of this work. However

  8. Develop and demonstrate a methodology using Janus(A) to analyze advanced technologies.

    Wright, Jerry Vernon


    Approved for public release; Distribution is unlimited This thesis presents a study of a methodology for analyzing advanced technologies using the Janus(A) High Resolution Combat Model. The goal of this research was to verify that the methodology using Janus(A) gave expected or realistic results. The methodology used a case where the results were known: the addition of a long range direct fire weapon into a force on force battle. Both the weapon characteristics and force mixes were used as...

  9. Weather Typing Statistical Downscaling with dsclim: Diagnostic methodology and configuration sensitivity

    Page, C.; Albertus, G.


    The 8-km output of the statistical downscaling methodology dsclim has been used since a few years to perform impacts and adaptation studies in France. The dsclim method is resampling the Météo-France SAFRAN observation mesoscale analysis. Since then, the SAFRAN observation period has been extended from 1981-2005 to 1958-2012. At the same time, there are strong needs of cross-national impact studies, hence the required use of an European observation dataset in the methodology. In this context, a diagnostic package has been developed to properly evaluate the downscaling methodology and its performance: it enables to evaluate the sensitivity and the impacts of the changes in its configuration, taking also properly into account stochastic aspects. In this study we evaluated the impacts on the results with respect to the extension of the learning period from 1981-2005 to 1958-2012, as well as the comparison on the use of the EOBS dataset instead of SAFRAN, having the objective of running dsclim over a larger region within the EU FP7 SPECS project and the EU COST Action VALUE downscaling methods intercomparison. This study was funded by the EU project SPECS funded by the European Commission's Seventh Framework Research Programme under the grant agreement 243964.

  10. Safety evaluation methodology for advanced coal extraction systems

    Zimmerman, W. F.


    Qualitative and quantitative evaluation methods for coal extraction systems were developed. The analysis examines the soundness of the design, whether or not the major hazards have been eliminated or reduced, and how the reduction would be accomplished. The quantitative methodology establishes the approximate impact of hazards on injury levels. The results are weighted by peculiar geological elements, specialized safety training, peculiar mine environmental aspects, and reductions in labor force. The outcome is compared with injury level requirements based on similar, safer industries to get a measure of the new system's success in reducing injuries. This approach provides a more detailed and comprehensive analysis of hazards and their effects than existing safety analyses.

  11. Electric and plug-in hybrid vehicles advanced simulation methodologies

    Varga, Bogdan Ovidiu; Moldovanu, Dan; Iclodean, Calin


    This book is designed as an interdisciplinary platform for specialists working in electric and plug-in hybrid electric vehicles powertrain design and development, and for scientists who want to get access to information related to electric and hybrid vehicle energy management, efficiency and control. The book presents the methodology of simulation that allows the specialist to evaluate electric and hybrid vehicle powertrain energy flow, efficiency, range and consumption. The mathematics behind each electric and hybrid vehicle component is explained and for each specific vehicle the powertrain

  12. Advanced Laser and RF Plasma Sources and Diagnostics


    jacks, fibers, collimators, and breadboards $19,832.71 Interferometry Gunn diode and I-Q mixer $6,775.00 RF Components and Automation High...temperature diagnostics for both our laser window and radiofrequency air plasmas. We have also acquired a tunable 668 nm diode laser, optical filters...diagnostics for both our laser window and radiofrequency air plasmas. We have also acquired a tunable 668 nm diode laser, optical filters, splitters

  13. Molecular diagnostics for Chagas disease: up to date and novel methodologies.

    Alonso-Padilla, Julio; Gallego, Montserrat; Schijman, Alejandro G; Gascon, Joaquim


    Chagas disease is caused by the parasite Trypanosoma cruzi. It affects 7 million people, mainly in Latin America. Diagnosis is usually made serologically, but at some clinical scenarios serology cannot be used. Then, molecular detection is required for early detection of congenital transmission, treatment response follow up, and diagnosis of immune-suppression reactivation. However, present tests are technically demanding and require well-equipped laboratories which make them unfeasible in low-resources endemic regions. Areas covered: Available molecular tools for detection of T. cruzi DNA, paying particular attention to quantitative PCR protocols, and to the latest developments of user-friendly molecular diagnostic methodologies. Expert commentary: In the absence of appropriate biomarkers, molecular diagnosis is the only option for the assessment of treatment response. Besides, it is very useful for the early detection of acute infections, like congenital cases. Since current Chagas disease molecular tests are restricted to referential labs, research efforts must focus in the implementation of easy-to-use diagnostic tools in order to overcome the access to diagnosis gap.

  14. Fuzzy portfolio optimization advances in hybrid multi-criteria methodologies

    Gupta, Pankaj; Inuiguchi, Masahiro; Chandra, Suresh


    This monograph presents a comprehensive study of portfolio optimization, an important area of quantitative finance. Considering that the information available in financial markets is incomplete and that the markets are affected by vagueness and ambiguity, the monograph deals with fuzzy portfolio optimization models. At first, the book makes the reader familiar with basic concepts, including the classical mean–variance portfolio analysis. Then, it introduces advanced optimization techniques and applies them for the development of various multi-criteria portfolio optimization models in an uncertain environment. The models are developed considering both the financial and non-financial criteria of investment decision making, and the inputs from the investment experts. The utility of these models in practice is then demonstrated using numerical illustrations based on real-world data, which were collected from one of the premier stock exchanges in India. The book addresses both academics and professionals pursuin...

  15. Advances in Artificial Neural Networks – Methodological Development and Application

    Yanbo Huang


    Full Text Available Artificial neural networks as a major soft-computing technology have been extensively studied and applied during the last three decades. Research on backpropagation training algorithms for multilayer perceptron networks has spurred development of other neural network training algorithms for other networks such as radial basis function, recurrent network, feedback network, and unsupervised Kohonen self-organizing network. These networks, especially the multilayer perceptron network with a backpropagation training algorithm, have gained recognition in research and applications in various scientific and engineering areas. In order to accelerate the training process and overcome data over-fitting, research has been conducted to improve the backpropagation algorithm. Further, artificial neural networks have been integrated with other advanced methods such as fuzzy logic and wavelet analysis, to enhance the ability of data interpretation and modeling and to avoid subjectivity in the operation of the training algorithm. In recent years, support vector machines have emerged as a set of high-performance supervised generalized linear classifiers in parallel with artificial neural networks. A review on development history of artificial neural networks is presented and the standard architectures and algorithms of artificial neural networks are described. Furthermore, advanced artificial neural networks will be introduced with support vector machines, and limitations of ANNs will be identified. The future of artificial neural network development in tandem with support vector machines will be discussed in conjunction with further applications to food science and engineering, soil and water relationship for crop management, and decision support for precision agriculture. Along with the network structures and training algorithms, the applications of artificial neural networks will be reviewed as well, especially in the fields of agricultural and biological

  16. A double-fuzzy diagnostic methodology dedicated to online fault diagnosis of proton exchange membrane fuel cell stacks

    Zheng, Zhixue; Péra, Marie-Cécile; Hissel, Daniel; Becherif, Mohamed; Agbli, Kréhi-Serge; Li, Yongdong


    To improve the performance and lifetime of the low temperature polymer electrolyte membrane fuel cell (PEMFC) stack, water management is an important issue. This paper aims at developing an online diagnostic methodology with the capability of discriminating different degrees of flooding/drying inside the fuel cell stack. Electrochemical impedance spectroscopy (EIS) is utilized as a basis tool and a double-fuzzy method consisting of fuzzy clustering and fuzzy logic is developed to mine diagnostic rules from the experimental data automatically. Through online experimental verification, a high interpretability and computational efficiency of the proposed methodology can be achieved.

  17. Advanced radiation measurement techniques in diagnostic radiology and molecular imaging.

    Del Guerra, Alberto; Belcari, Nicola; Llacer, Gabriela Llosa; Marcatili, Sara; Moehrs, Sascha; Panetta, Daniele


    This paper reports some technological advances recently achieved in the fields of micro-CT and small animal PET instrumentation. It highlights a balance between image-quality improvement and dose reduction. Most of the recent accomplishments in these fields are due to the use of novel imaging sensors such as CMOS-based X-ray detectors and silicon photomultipliers (SiPM). Some of the research projects carried out at the University of Pisa for the development of such advanced radiation imaging technology are also described.

  18. Combustion and Heat Transfer Studies Utilizing Advanced Diagnostics: Combustion Studies


    Appendices D, E, and F). The two main modeling approaches that enabled the calculation of stability from thermochemistry considera- tions are those of...Parallel TEACH -1Te Code Using an Approximately Implicit Algorithm." Proc. Tie prime authors of this report (G. Sturgess, D. Ballal S"ym Recem Advances and

  19. Advances in nucleic acid-based diagnostics of bacterial infections

    Barken, Kim Bundvig; Haagensen, Janus Anders Juul; Tolker-Nielsen, Tim


    and slow growing microorgansims. The widespread use of antibiotics has resulted in an increased number of cases with resistant microorganisms such as methicillin-resistant Staphylococcus aureus, vancomycin resistant enterococci, and multidrug-resistant Mycobacterium tuberculosis. Rapid detection...... of multiparameter assays where several pathogens and antibiotic resistance genes can be detected simultaneously.......Methods for rapid detection of infectious bacteria and antimicrobial-resistant pathogens have evolved significantly over the last decade. Many of the new procedures are nucleic acid-based and replace conventional diagnostic methods like culturing which is time consuming especially with fastidious...

  20. Epidemiology of intestinal parasitosis in Italy between 2005 and 2008: diagnostic techniques and methodologies

    Daniele Crotti


    Full Text Available Aim of the study was to keep a real and actual photo relating to 2005-2008 regarding to diagnostic techniques and methodologies for intestinal parasites; so it would be possible to know specific epidemiology and suggest more rational and efficacious guide-lines. All members of AMCLI were involved in the proposal of a retrospective study regarding bowel parasites, helminths and protozoa.To engaged laboratories we asked how O&P was performed, if a specifical research for E. vermicularis and S. stercoralis was performed, if for the identification of D. fragilis, Entamoeba histolytica/dispar and Cryptosporidum spp were performed recommended specific permanent stains. 23 laboratories gave assent; but for an inferior number was possible to use the data for analysis and evaluation. Relating O&P only some laboratories performed permanent stains: Giemsa for D. fragilis, antigen and/or Trichrome stain for E. histolytica/dispar, antigen and/or acid fast stain for Cryptosporidium spp.Not all laboratories research specifically S. stercoralis. So the epidemiology is differentiated and related more to adequate or not adequate techniques than cohorts of examined populations. The overall positivity for parasites ranged from 0% to18.7%,for protozoa (pathogens or not were from 0% to 14.7%; for nematodes from 0% to 3.7%; for cestodes from 0% to 1.0%; for trematodes from 0% to 1.0%.Among helminths, E. vermicularis, followed by S. stercoralis, also in O&P, is the most frequent.The specific research of S. stercoralis gave a positivity from 0% to 33.3%; the cellophane tape test was positive for E. vermicularis from 0% fo 21.9% of cases.Among pathogen protozoa, D. fragilis, when permanent stain were applied, prevailed from 0% to 16.6%; G. duodenalis from 0.8% to 4.3%; E. histolytica/dispar, using a permanent stain or research of antigen, was identified from 0% to 20.6%. Coccidia were very rare, with Cryptosporidium spp observed from 0% to 5.2%. These are our conclusions

  1. A new methodology for the diagnostics of architectural elements in historical buildings

    Casula, Giuseppe; Fais, Silvana; Cuccuru, Francesco; Ligas, Paola; Giovanna Bianchi, Maria


    A new methodology is presented consisting of a multi-step procedure based on the integrated application of different diagnostic techniques aimed at recognizing altered and unaltered parts of architectural elements of ancient buildings and at identifying zones where structural damage has occurred on their surface. The methodology was tested on a historical building of the monumental compound in Piazza Palazzo in the historical center of the town of Cagliari (Italy). Three types of carbonate building materials have been used historically to construct ancient monuments in the historical center of Cagliari, which in order of increasing hardness are: Pietra Cantone, Tramezzario and Pietra Forte. Our methodology begins with an accurate microscopic examination of petrographic thin sections and scanning electron microscope (SEM) analysis of the above carbonate materials in order to identify their textural characteristics and especially the nature and distribution of their porosity. Other rock properties such as wet and dry bulk density were calculated from saturated and dry mass and volume respectively. In a second step we used a Leica HDS-6200 terrestrial laser scanner (TLS) to 3D model some building of the studied monumental compound (Piazza Palazzo). Surface geometrical anomalies have been modeled for the most interesting architectural elements, such as a Pietra Cantone portal in Late Gothic style inside the Antico Palazzo di Città, a historical building that hosts the civic museum bearing the same name. Since TLS technology is characterized by high productivity but is unable to investigate the inner parts of the studied materials, a third step of our procedure was complemented by several ultrasonic in situ and laboratory tests in the 54kHz - 82kHz range. The ultrasonic parameters, especially longitudinal and transversal velocities, can be measured very accurately and correlated with various material properties with reasonable confidence. This task has two objectives

  2. Test methodology for elemental sulfur resistant advanced materials for oil and gas field equipment

    Steinbeck, G. [Verein Deutscher Eisenhuettenleute, Duesseldorf (Germany); Bruckhoff, W. [BEB Erdgas und Erdoel GmbH, Hannover (Germany); Koehler, M. [Krupp-VDM AG, Werdohl (Germany); Schlerkmann, H. [Mannesmann Forschungsinstitut, Duisburg (Germany); Schmitt, G. [Iserlohn Polytechnic (Germany). Lab. for Corrosion Protection


    The great variety of methodologies for testing the performance of advanced materials for resistance to elemental sulfur in oil and gas industry prompted the Technical Committee for Corrosion of the German Iron and Steel Institute (VDEh) to define recommended test procedures. These procedures have already found wide acceptance in the German materials and oil and gas industry.

  3. Prejudice and Racism, Year 2008--Still Going Strong: Research on Reducing Prejudice with Recommended Methodological Advances

    Utsey, Shawn O.; Ponterotto, Joseph G.; Porter, Jerlym S.


    This article addresses the origins, mechanisms, and expressions of prejudice. A selective review of research finds strong support for the validity of G. W. Allport's (1954) contact hypothesis conditions in reducing prejudice. Methodological advances in the study of prejudice are reviewed, and implications of research findings for counselors are…

  4. Point of care diagnostics for sexually transmitted infections: perspectives and advances.

    Gaydos, Charlotte; Hardick, Justin


    Accurate and inexpensive point-of-care (POC) tests are urgently needed to control sexually transmitted infection epidemics, so that patients can receive immediate diagnoses and treatment. Current POC assays for Chlamydia trachomatis and Neisseria gonorrhoeae perform inadequately and require better assays. Diagnostics for Trichomonas vaginalis rely on wet preparation, with some notable advances. Serological POC assays for syphilis can impact resource-poor settings, with many assays available, but only one available in the U.S. HIV POC diagnostics demonstrate the best performance, with excellent assays available. There is a rapid assay for HSV lesion detection; but no POC serological assays are available. Despite the inadequacy of POC assays for treatable bacterial infections, application of technological advances offers the promise of advancing POC diagnostics for all sexually transmitted infections.

  5. Advanced Diagnostics and Instrumentation for Chemically Reactive Flow Systems.


    AO-Aill 912 STANFORD UNIV CA DEPT OF MECHANICAL ENINEERING F/S 20/5 ADVANCED IAGNOSTICS AN ZNSYR%0TATON FOR CHMICALLY R9[ACT!VY-fTCU) SP 1 R K HANSON...fused silica fiber optics. 2. development of hardware and software to modulate the dye laser wave- length, transfer detector signals to a dedicated...color display monitor, the high speed Versatec graphics printer and the CAMAC 4 M~z A/D system. We have installed the com- puter software system and

  6. Evidence of advanced stage colorectal cancer with longer diagnostic intervals

    Tørring, Marie Louise; Murchie, P; Hamilton, Willie


    population-based studies in Scotland, England, Canada, Denmark and Spain during 1997-2010 with a total of 11 720 newly diagnosed CRC patients, who had initially presented with symptoms to a primary care physician. Data were extracted from patient records, registries, audits and questionnaires, respectively...... of the primary care interval appears to have negative impact from day one.British Journal of Cancer advance online publication 8 August 2017; doi:10.1038/bjc.2017.236

  7. UV-VUV diagnostics for the Advanced Photon Source SASE FEL

    Hartog, P D; Benson, C; Erdmann, M; Lumpkin, Alex H; Makarov, O; Petra, M; Tieman, B; Trakhtenberg, E; Wiemerslage, G


    The Advanced Photon Source self-amplified spontaneous emission (SASE) free-electron laser (FEL) uses diagnostics between undulator sections to characterize the light and the electron beam. These diagnostics enable z-dependent measurements of the exponential growth of the radiation and of the microbunching. The original diagnostics were designed for visible light. To enable measurements down to 265 nm, UV-enhanced cameras and fused-silica lenses have been installed. We have now designed a diagnostics suite that will enable us to continue measurements down to 50 nm using reflective optics and back-illuminated CCD cameras operating in vacuum. We describe the enhancements to the diagnostics for operation in the UV and VUV.

  8. Advances and prospects for molecular diagnostics of fungal infections.

    Bretagne, Stéphane


    The polymerase chain reaction (PCR) methods published for the diagnosis of invasive fungal infections are still not included in the revised European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group definitions of IA. This could be achieved with consensual PCR procedures. A checklist of items has been proposed to improve the reliability of the results and clinicians' confidence in them, with emphasis on limiting false-positive results from contamination with either previously amplified products or environmental commensals. Internal amplification controls are mandatory to expose false-negative results. However, our ignorance of the origin and the kinetics of fungal DNA during an infection hamper the choice of the best specimen and DNA extraction protocol. Evidence is increasing that serum could be a good compromise between sensitivity and ease of DNA extraction. Once a technical consensus is achieved, clinical studies should be initiated to integrate quantitative PCR in the diagnostic armamentarium.

  9. Nondestructive Measurements for Diagnostics of Advanced Reactor Passive Components

    Prowant, Matthew S.; Dib, Gerges; Roy, Surajit; Luzi, Lorenzo; Ramuhalli, Pradeep


    Information on advanced reactor (AdvRx) component condition and failure probability is necessary to maintaining adequate safety margins and avoiding unplanned shutdowns, both of which have regulatory and economic consequences. Prognostic health management (PHM) technologies provide one approach to addressing these needs by providing the technical means for lifetime management of significant passive components and reactor internals. However, such systems require measurement data that are sensitive to degradation of the component. This paper describes results to date of ongoing research on nondestructive measurements of component condition for degradation mechanisms of relevance to AdvRx concepts. The focus of this paper is on in-situ ultrasonic measurements during high-temperature creep degradation. The data were analyzed to assess the sensitivity of the measurements to creep degradation, with the specific objective of assessing the suitability of the resulting correlations for remaining life prediction. The details of the measurements, results of data analysis, and ongoing research in this area are discussed.

  10. Study of an experimental methodology for thermal properties diagnostic of building envelop

    Yang, Yingying; Sempy, Alain; Vogt Wu, Tingting; Sommier, Alain; Dumoulin, Jean; Batsale, Jean Christophe


    The building envelope plays a critical role in determining levels of comfort and building efficiency. Its real thermal properties characterization is of major interest to be able to diagnose energy efficiency performance of buildings (new construction and retrofitted existing old building). Research and development on a possible methodology for energy diagnostic of the building envelop is a hot topic and necessary trend. Many kinds of sensors and instruments are used for the studies. The application of infrared (IR) thermography in non-destructive evaluation has been widely employed for qualitative evaluations for building diagnostics; meanwhile, the IR thermography technology also has a large potentiality for the evaluation of the thermal characteristics of the building envelope. Some promising recent research studies have been carried out with such contactless measurement technique. Nevertheless, research efforts are still required for in situ measurements under natural environmental conditions. In order to develop new solutions for non-intrusive evaluation of local thermal performance, enabling quantitative assessment of thermal properties of buildings and materials, experiments were carried out on a multi-layer pratical scale wall fixed on a caisson placed in a climatic chamber. Six halogen lamps (1.5 kW for each lamp) placed in front of objective wall were used to emulate sunny conditions. The radiative heat flux emitted was monitored and modulated with time according to typical weather data set encountered in France. Both steady state and transient regime heat transfer were studied during these experiments. Contact sensors (thermocouples, heat flux meters, Peltier sensors) and non-contact sensors (thermal IR camera, pyranometer) were used to measure the temperatures and heat flux density evolution. It has to be noticed that the Peltier sensors have been tuned and used with a specific processing to set them compliant for heat flux density measurements. The

  11. How to Use the DX SYSTEM of Diagnostic Testing. Methodology Project.

    McArthur, David; Cabello, Beverly

    The DX SYSTEM of Diagnostic Testing is an easy-to-use computerized system for developing and administering diagnostic tests. A diagnostic test measures a student's mastery of a specific domain (skill or content area). It examines the necessary subskills hierarchically from the most to the least complex. The DX SYSTEM features tailored testing with…

  12. Pott's Spine: Diagnostic Imaging Modalities and Technology Advancements

    Ansari, Sajid; Amanullah, Md. Farid; Ahmad, Kaleem; Rauniyar, Raj Kumar


    Spinal tuberculosis (TB) or Pott's spine is the commonest extrapulmonary manifestation of TB. It spreads through hematogenous route. Clinically, it presents with constitutional symptoms, back pain, tenderness, paraplegia or paraparesis, and kyphotic or scoliotic deformities. Pott's spine accounts for 2% of all cases of TB, 15% of extrapulmonary, and 50% of skeletal TB. The paradiscal, central, anterior subligamentous, and neural arch are the common vertebral lesions. Thoracic vertebrae are commonly affected followed by lumbar and cervical vertebrae. Plain radiographs are usually the initial investigation in spinal TB. For a radiolucent lesion to be apparent on a plain radiograph there should be 30% of bone mineral loss. Computed tomographic scanning provides much better bony detail of irregular lytic lesions, sclerosis, disc collapse, and disruption of bone circumference than plain radiograph. Magnetic resonance imaging (MRI) is the best diagnostic modality for Pott's spine and is more sensitive than other modalities. MRI frequently demonstrates disc collapse/destruction, cold abscess, vertebral wedging/collapse, marrow edema, and spinal deformities. Ultrasound and computed tomographic guided needle aspiration or biopsy is the technique for early histopathological diagnosis. Recently, the coexistence of human immunodeficiency virus infections and TB has been increased globally. In recent years, diffusion-weighted MRI (DW-MRI) and apparent diffusion coefficient values in combination with MRI are used to some extent in the diagnosis of spinal TB. We have reviewed related literature through internet. The terms searched on Google scholar and PubMed are TB, extrapulmonary TB, skeletal TB, spinal TB, Pott's spine, Pott's paraplegia, MRI, and computed tomography (CT). PMID:24020048

  13. Methodological Grounds of Formation of the Scorecard of Diagnostics of the Innovation Component of Technological Processes of Industrial Enterprises

    Zhezhuha Volodymyr Yo.


    Full Text Available The goal of the article is development of scientific provisions with respect of methodological specific features of formation of the scorecard of diagnostics of the innovation component of technological processes of industrial enterprises. The article proves fragmentariness of views of theoreticians and practitioners on this problem. It justifies a necessity of formation of these indicators from the point of view of a system approach, consequently, accounting of all interconnections and interdependencies between them, and also coverage of main factors that identify the diagnosed innovation component. Pursuant to result of the study the article specifies system properties of the scorecard of diagnostics of the innovation component of technological processes of industrial enterprises. It reveals a possibility of application of two alternative approaches to formation of this scorecard, and also establishes their advantages and shortcomings. It gives a number of requirements, which have to be met when selecting, developing and forming the scorecard of diagnostics of the innovation component of technological processes of industrial enterprises. It reflects key issues that should form the basis of the methodological approach to formation of this system. It shows typology of indicators of diagnostics of the innovation component of technological processes of industrial enterprises, which gives subjects of diagnostics a possibility to select relevant indicators depending on the set criteria and restrictions. Prospects of further studies in this direction should lie in development of the system of a specific scorecard of diagnostics of each innovation component of technological processes of industrial enterprises with consideration of methodological specific features of its formation described in the article.

  14. Advanced Ground Systems Maintenance Physics Models For Diagnostics Project

    Perotti, Jose M.


    The project will use high-fidelity physics models and simulations to simulate real-time operations of cryogenic and systems and calculate the status/health of the systems. The project enables the delivery of system health advisories to ground system operators. The capability will also be used to conduct planning and analysis of cryogenic system operations. This project will develop and implement high-fidelity physics-based modeling techniques tosimulate the real-time operation of cryogenics and other fluids systems and, when compared to thereal-time operation of the actual systems, provide assessment of their state. Physics-modelcalculated measurements (called “pseudo-sensors”) will be compared to the system real-timedata. Comparison results will be utilized to provide systems operators with enhanced monitoring ofsystems' health and status, identify off-nominal trends and diagnose system/component failures.This capability can also be used to conduct planning and analysis of cryogenics and other fluidsystems designs. This capability will be interfaced with the ground operations command andcontrol system as a part of the Advanced Ground Systems Maintenance (AGSM) project to helpassure system availability and mission success. The initial capability will be developed for theLiquid Oxygen (LO2) ground loading systems.

  15. Advancement in contemporary diagnostic and therapeutic approaches for rheumatoid arthritis.

    Kumar, L Dinesh; Karthik, R; Gayathri, N; Sivasudha, T


    This review is intended to provide a summary of the pathogenesis, diagnosis and therapies for rheumatoid arthritis. Rheumatoid arthritis (RA) is a common form of inflammatory autoimmune disease with unknown aetiology. Bone degradation, cartilage and synovial destruction are three major pathways of RA pathology. Sentinel cells includes dendritic cells, macrophages and mast cells bound with the auto antigens and initiate the inflammation of the joints. Those cells further activates the immune cells on synovial membrane by releasing inflammatory cytokines Interleukin 1, 6, 17, etc., Diagnosis of this disease is a combinational approach comprises radiological imaging, blood and serology markers assessment. The treatment of RA still remain inadequate due to the lack of knowledge in disease development. Non-steroidal anti-inflammatory drugs, disease modifying anti rheumatic drugs and corticosteroid are the commercial drugs to reduce pain, swelling and suppressing several disease factors. Arthroscopy will be an useful method while severe degradation of joint tissues. Gene therapy is a major advancement in RA. Suppressor gene locus of inflammatory mediators and matrix degrading enzymes were inserted into the affected area to reduce the disease progression. To overcome the issues aroused from those therapies like side effects and expenses, phytocompounds have been investigated and certain compounds are proved for their anti-arthritic potential. Furthermore certain complementary alternative therapies like yoga, acupuncture, massage therapy and tai chi have also been proved for their capability in RA treatment.

  16. Advanced biosensing methodologies developed for evaluating performance quality and safety of emerging biophotonics technologies and medical devices (Conference Presentation)

    Ilev, Ilko K.; Walker, Bennett; Calhoun, William; Hassan, Moinuddin


    Biophotonics is an emerging field in modern biomedical technology that has opened up new horizons for transfer of state-of-the-art techniques from the areas of lasers, fiber optics and biomedical optics to the life sciences and medicine. This field continues to vastly expand with advanced developments across the entire spectrum of biomedical applications ranging from fundamental "bench" laboratory studies to clinical patient "bedside" diagnostics and therapeutics. However, in order to translate these technologies to clinical device applications, the scientific and industrial community, and FDA are facing the requirement for a thorough evaluation and review of laser radiation safety and efficacy concerns. In many cases, however, the review process is complicated due the lack of effective means and standard test methods to precisely analyze safety and effectiveness of some of the newly developed biophotonics techniques and devices. There is, therefore, an immediate public health need for new test protocols, guidance documents and standard test methods to precisely evaluate fundamental characteristics, performance quality and safety of these technologies and devices. Here, we will overview our recent developments of novel test methodologies for safety and efficacy evaluation of some emerging biophotonics technologies and medical devices. These methodologies are based on integrating the advanced features of state-of-the-art optical sensor technologies and approaches such as high-resolution fiber-optic sensing, confocal and optical coherence tomography imaging, and infrared spectroscopy. The presentation will also illustrate some methodologies developed and implemented for testing intraocular lens implants, biochemical contaminations of medical devices, ultrahigh-resolution nanoscopy, and femtosecond laser therapeutics.

  17. Advancing Nursing Research in the Visual Era: Reenvisioning the Photovoice Process Across Phenomenological, Grounded Theory, and Critical Theory Methodologies.

    Evans-Agnew, Robin A; Boutain, Doris M; Rosemberg, Marie-Anne S

    Photovoice is a powerful research method that employs participant photography for advancing voice, knowledge, and transformative change among groups historically or currently marginalized. Paradoxically, this research method risks exploitation of participant voice because of weak methodology to method congruence. The purposes of this retrospective article are to revisit current interdisciplinary research using photovoice and to suggest how to advance photovoice by improving methodology-method congruence. Novel templates are provided for improving the photovoice process across phenomenological, grounded theory, and critical theory methodologies.

  18. Application of infinite model predictive control methodology to other advanced controllers.

    Abu-Ayyad, M; Dubay, R; Hernandez, J M


    This paper presents an application of most recent developed predictive control algorithm an infinite model predictive control (IMPC) to other advanced control schemes. The IMPC strategy was derived for systems with different degrees of nonlinearity on the process gain and time constant. Also, it was shown that IMPC structure uses nonlinear open-loop modeling which is conducted while closed-loop control is executed every sampling instant. The main objective of this work is to demonstrate that the methodology of IMPC can be applied to other advanced control strategies making the methodology generic. The IMPC strategy was implemented on several advanced controllers such as PI controller using Smith-Predictor, Dahlin controller, simplified predictive control (SPC), dynamic matrix control (DMC), and shifted dynamic matrix (m-DMC). Experimental work using these approaches combined with IMPC was conducted on both single-input-single-output (SISO) and multi-input-multi-output (MIMO) systems and compared with the original forms of these advanced controllers. Computer simulations were performed on nonlinear plants demonstrating that the IMPC strategy can be readily implemented on other advanced control schemes providing improved control performance. Practical work included real-time control applications on a DC motor, plastic injection molding machine and a MIMO three zone thermal system.

  19. A Methodology for the Development of a Reliability Database for an Advanced Reactor Probabilistic Risk Assessment

    Grabaskas, Dave; Brunett, Acacia J.; Bucknor, Matthew


    GE Hitachi Nuclear Energy (GEH) and Argonne National Laboratory are currently engaged in a joint effort to modernize and develop probabilistic risk assessment (PRA) techniques for advanced non-light water reactors. At a high level the primary outcome of this project will be the development of next-generation PRA methodologies that will enable risk-informed prioritization of safety- and reliability-focused research and development, while also identifying gaps that may be resolved through additional research. A subset of this effort is the development of a reliability database (RDB) methodology to determine applicable reliability data for inclusion in the quantification of the PRA. The RDB method developed during this project seeks to satisfy the requirements of the Data Analysis element of the ASME/ANS Non-LWR PRA standard. The RDB methodology utilizes a relevancy test to examine reliability data and determine whether it is appropriate to include as part of the reliability database for the PRA. The relevancy test compares three component properties to establish the level of similarity to components examined as part of the PRA. These properties include the component function, the component failure modes, and the environment/boundary conditions of the component. The relevancy test is used to gauge the quality of data found in a variety of sources, such as advanced reactor-specific databases, non-advanced reactor nuclear databases, and non-nuclear databases. The RDB also establishes the integration of expert judgment or separate reliability analysis with past reliability data. This paper provides details on the RDB methodology, and includes an example application of the RDB methodology for determining the reliability of the intermediate heat exchanger of a sodium fast reactor. The example explores a variety of reliability data sources, and assesses their applicability for the PRA of interest through the use of the relevancy test.

  20. Does the use of diagnostic PET/CT cause stage migration in patients with primary advanced ovarian cancer?

    Risum, S; Høgdall, C; Loft, Annika


    To investigate if the use of diagnostic FDG-PET/CT leads to stage migration in patients with advanced ovarian cancer and to evaluate the prognostic significance of FDG-PET/CT.......To investigate if the use of diagnostic FDG-PET/CT leads to stage migration in patients with advanced ovarian cancer and to evaluate the prognostic significance of FDG-PET/CT....

  1. Review of advanced control rooms: Methodological considerations for the use of HFE guidelines

    O`Hara, J.M.


    Control rooms for advanced nuclear power plants use advanced human-system interface (HSI) technologies that may have significant implications for plant safety in that they will affect the operator`s overall role in the system and the ways in which operators interact with the system. The US Nuclear Regulatory Commission (NRC) reviews HSIs to ensure that they are designed to accepted human factors engineering (HFE) principles. The principal review guidance, however, is more than ten-years old (US NRC, 1981). Accordingly, an Advanced HSI Design Review Guideline (DRG) was developed to provide criteria for these reviews. The DRG contains seven major sections: Information Display, User-System Interaction, Process Control and Input Devices, Alarms, Analysis and Decision Aids, Inter-Personnel Communication, and Workplace Design (see O`Hara & Brown, 1993). The purpose of this paper is to describe the methodology for DRG use.

  2. Methodological deficits in diagnostic research using '-omics' technologies: evaluation of the QUADOMICS tool and quality of recently published studies.

    Lucy A Parker

    Full Text Available BACKGROUND: QUADOMICS is an adaptation of QUADAS (a quality assessment tool for use in systematic reviews of diagnostic accuracy studies, which takes into account the particular challenges presented by '-omics' based technologies. Our primary objective was to evaluate the applicability and consistency of QUADOMICS. Subsequently we evaluated and describe the methodological quality of a sample of recently published studies using the tool. METHODOLOGY/PRINCIPAL FINDINGS: 45'-omics'-based diagnostic studies were identified by systematic search of Pubmed using suitable MeSH terms ("Genomics", "Sensitivity and specificity", "Diagnosis". Three investigators independently assessed the quality of the articles using QUADOMICS and met to compare observations and generate a consensus. Consistency and applicability was assessed by comparing each reviewer's original rating with the consensus. Methodological quality was described using the consensus rating. Agreement was above 80% for all three reviewers. Four items presented difficulties with application, mostly due to the lack of a clearly defined gold standard. Methodological quality of our sample was poor; studies met roughly half of the applied criteria (mean +/- sd, 54.7+/-18.4%. Few studies were carried out in a population that mirrored the clinical situation in which the test would be used in practice, (6, 13.3%; none described patient recruitment sufficiently; and less than half described clinical and physiological factors that might influence the biomarker profile (20, 44.4%. CONCLUSIONS: The QUADOMICS tool can consistently be applied to diagnostic '-omics' studies presently published in biomedical journals. A substantial proportion of reports in this research field fail to address design issues that are fundamental to make inferences relevant for patient care.

  3. Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application.

    Gong, Max M; Sinton, David


    Infectious diseases are a major global health issue. Diagnosis is a critical first step in effectively managing their spread. Paper-based microfluidic diagnostics first emerged in 2007 as a low-cost alternative to conventional laboratory testing, with the goal of improving accessibility to medical diagnostics in developing countries. In this review, we examine the advances in paper-based microfluidic diagnostics for medical diagnosis in the context of global health from 2007 to 2016. The theory of fluid transport in paper is first presented. The next section examines the strategies that have been employed to control fluid and analyte transport in paper-based assays. Tasks such as mixing, timing, and sequential fluid delivery have been achieved in paper and have enabled analytical capabilities comparable to those of conventional laboratory methods. The following section examines paper-based sample processing and analysis. The most impactful advancement here has been the translation of nucleic acid analysis to a paper-based format. Smartphone-based analysis is another exciting development with potential for wide dissemination. The last core section of the review highlights emerging health applications, such as male fertility testing and wearable diagnostics. We conclude the review with the future outlook, remaining challenges, and emerging opportunities.

  4. Comparison of novel clinically applicable methodology for sensitive diagnostics of cartilage degeneration

    P Kiviranta


    Full Text Available In order efficiently to target therapies intending to stop or reverse degenerative processes of articular cartilage, it would be crucial to diagnose osteoarthritis (OA earlier and more sensitively than is possible with the existing clinical methods. Unfortunately, current clinical methods for OA diagnostics are insensitive for detecting the early degenerative changes, e.g., arising from collagen network damage or proteoglycan depletion. We have recently investigated several novel quantitative biophysical methods, including ultrasound indentation, quantitative ultrasound techniques and magnetic resonance imaging, for diagnosing the degenerative changes of articular cartilage, typical for OA. In this study, the combined results of these novel diagnostic methods were compared with histological (Mankin score, MS, compositional (proteoglycan, collagen and water content and mechanical (dynamic and equilibrium moduli reference measurements of the same bovine cartilage samples. Receiver operating characteristics (ROC analysis was conducted to judge the diagnostic performance of each technique. Indentation and ultrasound techniques provided the most sensitive measures to differentiate samples of intact appearance (MS=0 from early (13 degeneration. Furthermore, these techniques were good predictors of tissue composition and mechanical properties. The specificity and sensitivity analyses revealed that the mechano-acoustic methods, when further developed for in vivo use, may provide more sensitive probes for OA diagnostics than the prevailing qualitative X-ray and arthroscopic techniques. Noninvasive quantitative MRI measurements showed slightly lower diagnostic performance than mechano-acoustic techniques. The compared methods could possibly also be used for the quantitative monitoring of success of cartilage repair.

  5. Immunoassay Methods and their Applications in Pharmaceutical Analysis: Basic Methodology and Recent Advances.

    Darwish, Ibrahim A


    Immunoassays are bioanalytical methods in which the quantitation of the analyte depends on the reaction of an antigen (analyte) and an antibody. Immunoassays have been widely used in many important areas of pharmaceutical analysis such as diagnosis of diseases, therapeutic drug monitoring, clinical pharmacokinetic and bioequivalence studies in drug discovery and pharmaceutical industries. The importance and widespread of immunoassay methods in pharmaceutical analysis are attributed to their inherent specificity, high-throughput, and high sensitivity for the analysis of wide range of analytes in biological samples. Recently, marked improvements were achieved in the field of immunoassay development for the purposes of pharmaceutical analysis. These improvements involved the preparation of the unique immunoanalytical reagents, analysis of new categories of compounds, methodology, and instrumentation. The basic methodologies and recent advances in immunoassay methods applied in different fields of pharmaceutical analysis have been reviewed.

  6. Diagnostic methodology is critical for accurately determining the prevalence of ichthyophonus infections in wild fish populations

    Kocan, R.; Dolan, H.; Hershberger, P.


    Several different techniques have been employed to detect and identify Ichthyophonus spp. in infected fish hosts; these include macroscopic observation, microscopic examination of tissue squashes, histological evaluation, in vitro culture, and molecular techniques. Examination of the peer-reviewed literature revealed that when more than 1 diagnostic method is used, they often result in significantly different results; for example, when in vitro culture was used to identify infected trout in an experimentally exposed population, 98.7% of infected trout were detected, but when standard histology was used to confirm known infected tissues from wild salmon, it detected ~50% of low-intensity infections and ~85% of high-intensity infections. Other studies on different species reported similar differences. When we examined a possible mechanism to explain the disparity between different diagnostic techniques, we observed non-random distribution of the parasite in 3-dimensionally visualized tissue sections from infected hosts, thus providing a possible explanation for the different sensitivities of commonly used diagnostic techniques. Based on experimental evidence and a review of the peer-reviewed literature, we have concluded that in vitro culture is currently the most accurate diagnostic technique for determining infection prevalence of Ichthyophonus, particularly when the exposure history of the population is not known.

  7. Sustainability of evidence-based healthcare: research agenda, methodological advances, and infrastructure support.

    Proctor, Enola; Luke, Douglas; Calhoun, Annaliese; McMillen, Curtis; Brownson, Ross; McCrary, Stacey; Padek, Margaret


    Little is known about how well or under what conditions health innovations are sustained and their gains maintained once they are put into practice. Implementation science typically focuses on uptake by early adopters of one healthcare innovation at a time. The later-stage challenges of scaling up and sustaining evidence-supported interventions receive too little attention. This project identifies the challenges associated with sustainability research and generates recommendations for accelerating and strengthening this work. A multi-method, multi-stage approach, was used: (1) identifying and recruiting experts in sustainability as participants, (2) conducting research on sustainability using concept mapping, (3) action planning during an intensive working conference of sustainability experts to expand the concept mapping quantitative results, and (4) consolidating results into a set of recommendations for research, methodological advances, and infrastructure building to advance understanding of sustainability. Participants comprised researchers, funders, and leaders in health, mental health, and public health with shared interest in the sustainability of evidence-based health care. Prompted to identify important issues for sustainability research, participants generated 91 distinct statements, for which a concept mapping process produced 11 conceptually distinct clusters. During the conference, participants built upon the concept mapping clusters to generate recommendations for sustainability research. The recommendations fell into three domains: (1) pursue high priority research questions as a unified agenda on sustainability; (2) advance methods for sustainability research; (3) advance infrastructure to support sustainability research. Implementation science needs to pursue later-stage translation research questions required for population impact. Priorities include conceptual consistency and operational clarity for measuring sustainability, developing evidence

  8. Improved best estimate plus uncertainty methodology including advanced validation concepts to license evolving nuclear reactors

    Unal, Cetin [Los Alamos National Laboratory; Williams, Brian [Los Alamos National Laboratory; Mc Clure, Patrick [Los Alamos National Laboratory; Nelson, Ralph A [IDAHO NATIONAL LAB


    Many evolving nuclear energy programs plan to use advanced predictive multi-scale multi-physics simulation and modeling capabilities to reduce cost and time from design through licensing. Historically, the role of experiments was primary tool for design and understanding of nuclear system behavior while modeling and simulation played the subordinate role of supporting experiments. In the new era of multi-scale multi-physics computational based technology development, the experiments will still be needed but they will be performed at different scales to calibrate and validate models leading predictive simulations. Cost saving goals of programs will require us to minimize the required number of validation experiments. Utilization of more multi-scale multi-physics models introduces complexities in the validation of predictive tools. Traditional methodologies will have to be modified to address these arising issues. This paper lays out the basic aspects of a methodology that can be potentially used to address these new challenges in design and licensing of evolving nuclear technology programs. The main components of the proposed methodology are verification, validation, calibration, and uncertainty quantification. An enhanced calibration concept is introduced and is accomplished through data assimilation. The goal is to enable best-estimate prediction of system behaviors in both normal and safety related environments. To achieve this goal requires the additional steps of estimating the domain of validation and quantification of uncertainties that allow for extension of results to areas of the validation domain that are not directly tested with experiments, which might include extension of the modeling and simulation (M&S) capabilities for application to full-scale systems. The new methodology suggests a formalism to quantify an adequate level of validation (predictive maturity) with respect to required selective data so that required testing can be minimized for cost

  9. Probabilistic Analysis of Passive Safety System Reliability in Advanced Small Modular Reactors: Methodologies and Lessons Learned

    Grabaskas, David; Bucknor, Matthew; Brunett, Acacia; Grelle, Austin


    Many advanced small modular reactor designs rely on passive systems to fulfill safety functions during accident sequences. These systems depend heavily on boundary conditions to induce a motive force, meaning the system can fail to operate as intended due to deviations in boundary conditions, rather than as the result of physical failures. Furthermore, passive systems may operate in intermediate or degraded modes. These factors make passive system operation difficult to characterize with a traditional probabilistic framework that only recognizes discrete operating modes and does not allow for the explicit consideration of time-dependent boundary conditions. Argonne National Laboratory has been examining various methodologies for assessing passive system reliability within a probabilistic risk assessment for a station blackout event at an advanced small modular reactor. This paper describes the most promising options: mechanistic techniques, which share qualities with conventional probabilistic methods, and simulation-based techniques, which explicitly account for time-dependent processes. The primary intention of this paper is to describe the strengths and weaknesses of each methodology and highlight the lessons learned while applying the two techniques while providing high-level results. This includes the global benefits and deficiencies of the methods and practical problems encountered during the implementation of each technique.

  10. Non-allergic rhinitis in children: Epidemiological aspects, pathological features, diagnostic methodology and clinical management.

    Poddighe, Dimitri; Gelardi, Matteo; Licari, Amelia; Del Giudice, Michele Miraglia; Marseglia, Gian Luigi


    Chronic rhinitis is a very common disease, as the prevalence in the general population resulted to be 40%. Allergic rhinitis has been considered to be the most frequent form of chronic rhinitis, as non-allergic rhinitis has been estimated to account for 25%. However, several evidences suggested that non-allergic rhinitis have been underrated, especially in children. In pediatrics, the diagnostic definition of non-allergic rhinitis has been often limited to the exclusion of an allergic sensitization. Actually, local allergic rhinitis has been often misdiagnosed as well as mixed rhinitis has not been recognized in most cases. Nasal cytology is a diagnostic procedure being suitable for routine clinical practice with children and could be a very useful tool to characterize and diagnose non-allergic rhinitis, providing important clues for epidemiological analysis and clinical management.

  11. Nanomaterials—Tools, Technology and Methodology of Nanotechnology Based Biomedical Systems for Diagnostics and Therapy

    Christian Schmidt


    Full Text Available Nanomedicine helps to fight diseases at the cellular and molecular level by utilizing unique properties of quasi-atomic particles at a size scale ranging from 1 to 100 nm. Nanoparticles are used in therapeutic and diagnostic approaches, referred to as theranostics. The aim of this review is to illustrate the application of general principles of nanotechnology to select examples of life sciences, molecular medicine and bio-assays. Critical aspects relating to those examples are discussed.

  12. Noninvasive Fetal Trisomy (NIFTY test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies

    Jiang Fuman


    Full Text Available Abstract Background Conventional prenatal screening tests, such as maternal serum tests and ultrasound scan, have limited resolution and accuracy. Methods We developed an advanced noninvasive prenatal diagnosis method based on massively parallel sequencing. The Noninvasive Fetal Trisomy (NIFTY test, combines an optimized Student’s t-test with a locally weighted polynomial regression and binary hypotheses. We applied the NIFTY test to 903 pregnancies and compared the diagnostic results with those of full karyotyping. Results 16 of 16 trisomy 21, 12 of 12 trisomy 18, two of two trisomy 13, three of four 45, X, one of one XYY and two of two XXY abnormalities were correctly identified. But one false positive case of trisomy 18 and one false negative case of 45, X were observed. The test performed with 100% sensitivity and 99.9% specificity for autosomal aneuploidies and 85.7% sensitivity and 99.9% specificity for sex chromosomal aneuploidies. Compared with three previously reported z-score approaches with/without GC-bias removal and with internal control, the NIFTY test was more accurate and robust for the detection of both autosomal and sex chromosomal aneuploidies in fetuses. Conclusion Our study demonstrates a powerful and reliable methodology for noninvasive prenatal diagnosis.

  13. Improving the diagnostic criteria for alcohol use disorders through survey methodology and cognitive interviewing.

    Mewton, Louise; Slade, Tim; Teesson, Maree; Memedovic, Sonja; Krueger, Robert F


    This study aims to identify problems in the structure and wording of questions designed to operationalize four DSM-IV diagnostic criteria for alcohol use disorders (AUDs): (1) use of alcohol in hazardous situations (hazard); (2) tolerance; (3) use of alcohol in larger amounts/longer periods than intended (larger/longer); (4) unsuccessful attempts to cut down or control alcohol use (quit/cut down). Ten experts appraised the questions related to these criteria in the WMH-CIDI according to a standardized checklist. These experts identified three main problems: (1) the double-barrelled nature of some of the questions; (2) definitional issues; and (3) unclear thresholds for criterion endorsement. Cognitive interviews of 100 young adult drinkers aged 18-24 were then conducted. The double-barrelled nature of the DSM-IV criteria led to their subsequent over- or under-endorsement. Key terms in the questions under investigation were defined inconsistently. There was also a large amount of variability in the thresholds at which larger/longer and quit/cut down were endorsed. Many of these problems could be linked back to the DSM-IV text. The findings raise questions as to the validity of AUD diagnoses when established via structured diagnostic interview. Further research should focus on testing alternative structure and wording of key AUD criteria to ensure accurate operationalizations of these criteria in structured diagnostic interviews.

  14. Piloting an advanced methodology to analyse health care policy networks: The example of Belgrade, Serbia

    Helmut Wenzel


    Full Text Available Aim: Political decisions usually emerge from the competing interests of politicians, voters, and special interest groups. We investigated the applicability of an advanced methodological concept to determine whether certain institutional positions in a cooperating network have influence on the decision-making procedures. To that end, we made use of the institutional network of relevant health care and health governance institutions, concentrated in Belgrade, Serbia. Methods: We used a Principal Component Analysis (PCA based on a combination of measures for centrality in order to evaluate the positions of 25 players in Belgrade‟s institutional network. Their directed links were determined by a simulated position approach employing the authors‟ long-term involvement. Software packages used consisted of Visone 2.9, UCINET 6, and KeyPlayer 1.44. Results: In our analysis, the network density score in Belgrade was 71%. The PCA revealed two dimensions: control and attractiveness. The Ministry of Health exerted the highest level of control but displayed a low attractiveness in terms of receiving links from important players. The National Health Insurance Fund had less control capacity but a high attractiveness. The National Institute of Public Health‟s position was characterized by a low control capacity and high attractiveness, whereas the National Drug Agency, the National Health Council, and Non-Governmental Organisations were no prominent players. Conclusions: The advanced methodologies used here to analyse the health care policy network in Belgrade provided consistent results indicating that the intended decentralization of the health care network in Belgrade may be incomplete, still with low participation of civil society representatives. With the present study we set the stage for a broad-range survey based data collection applying the methodology piloted in Belgrade.

  15. Quality Control Methodologies for Advanced EMI Sensor Data Acquisition and Anomaly Classification - Former Southwestern Proving Ground, Arkansas


    DEMONSTRATION REPORT Quality Control Methodologies for Advanced EMI Sensor Data Acquisition and Anomaly Classification – Former Southwestern...concentrations. A total of 11.23 acres of dynamic surveys were conducted using MetalMapper advanced electromagnetic induction ( EMI ) sensor. A total of...Order Navigation Points ................................................................................13 5.2.3 Initial EMI Survey

  16. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria.

    Dubois, Bruno; Feldman, Howard H; Jacova, Claudia; Hampel, Harald; Molinuevo, José Luis; Blennow, Kaj; DeKosky, Steven T; Gauthier, Serge; Selkoe, Dennis; Bateman, Randall; Cappa, Stefano; Crutch, Sebastian; Engelborghs, Sebastiaan; Frisoni, Giovanni B; Fox, Nick C; Galasko, Douglas; Habert, Marie-Odile; Jicha, Gregory A; Nordberg, Agneta; Pasquier, Florence; Rabinovici, Gil; Robert, Philippe; Rowe, Christopher; Salloway, Stephen; Sarazin, Marie; Epelbaum, Stéphane; de Souza, Leonardo C; Vellas, Bruno; Visser, Pieter J; Schneider, Lon; Stern, Yaakov; Scheltens, Philip; Cummings, Jeffrey L


    In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging-Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances to improve the diagnostic framework. On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent with the presence of Alzheimer's pathology. We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the preclinical states of AD. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. Distributed computing methodology for training neural networks in an image-guided diagnostic application.

    Plagianakos, V P; Magoulas, G D; Vrahatis, M N


    Distributed computing is a process through which a set of computers connected by a network is used collectively to solve a single problem. In this paper, we propose a distributed computing methodology for training neural networks for the detection of lesions in colonoscopy. Our approach is based on partitioning the training set across multiple processors using a parallel virtual machine. In this way, interconnected computers of varied architectures can be used for the distributed evaluation of the error function and gradient values, and, thus, training neural networks utilizing various learning methods. The proposed methodology has large granularity and low synchronization, and has been implemented and tested. Our results indicate that the parallel virtual machine implementation of the training algorithms developed leads to considerable speedup, especially when large network architectures and training sets are used.

  18. Recent biologic and genetic advances in neuroblastoma: Implications for diagnostic, risk stratification, and treatment strategies.

    Newman, Erika A; Nuchtern, Jed G


    Neuroblastoma is an embryonic cancer of neural crest cell lineage, accounting for up to 10% of all pediatric cancer. The clinical course is heterogeneous ranging from spontaneous regression in neonates to life-threatening metastatic disease in older children. Much of this clinical variance is thought to result from distinct pathologic characteristics that predict patient outcomes. Consequently, many research efforts have been focused on identifying the underlying biologic and genetic features of neuroblastoma tumors in order to more clearly define prognostic subgroups for treatment stratification. Recent technological advances have placed emphasis on the integration of genetic alterations and predictive biologic variables into targeted treatment approaches to improve patient survival outcomes. This review will focus on these recent advances and the implications they have on the diagnostic, staging, and treatment approaches in modern neuroblastoma clinical management. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Gender responsiveness diagnostic of national monitoring and evaluation systems – methodological reflections

    Madri S. Jansen van Rensburg


    Full Text Available Background: This article reflects on the implementation of a diagnostic study carried out to understand the gender responsiveness of the national monitoring and evaluation (M&E systems of Benin, South Africa and Uganda. Carrying out the study found that the potential for integrating the cross-cutting systems of gender and monitoring and evaluation (M&E are strong. At the same time, it highlighted a range of challenges intersecting these two areas of work. This article explores these issues, which range from logistical to conceptual.Objectives: This article aims to share reflections from the gender diagnostic study to enable more appropriate capacity building in the field of gender responsiveness in national M&E systems. Developing more sophisticated tools to measure gender responsiveness in complex contexts is critical. A better understanding of how gender and national M&E systems intersect is important to understanding firstly how we can more accurately measure the gender responsiveness of existing systems and secondly how better to engender capacity development initiatives.Method: As part of the Twende Mbele programme, Centre for Learning on Evaluation and Results (CLEAR commissioned Africa Gender and Development Evaluator’s Network (AGDEN to coordinate teams of researchers in Benin, Uganda, and South Africa to collaboratively develop the diagnostic tool, and then implement it by conducting a review of key documentation and to interview officials within the government wide monitoring and evaluation systems as well as the national gender machinery in each country.Results: The study found that the gender responsiveness of M&E systems across all three systems was unequal, but more importantly, it is important to do more work on how M&E and gender are conceptualised, to ensure this can be studied in a more meaningful way. To strengthen national monitoring and evaluation systems, gender responsiveness and equity must serve as a foundation for

  20. Work Domain Analysis Methodology for Development of Operational Concepts for Advanced Reactors

    Hugo, Jacques [Idaho National Lab. (INL), Idaho Falls, ID (United States)


    This report describes a methodology to conduct a Work Domain Analysis in preparation for the development of operational concepts for new plants. This method has been adapted from the classical method described in the literature in order to better deal with the uncertainty and incomplete information typical of first-of-a-kind designs. The report outlines the strategy for undertaking a Work Domain Analysis of a new nuclear power plant and the methods to be used in the development of the various phases of the analysis. Basic principles are described to the extent necessary to explain why and how the classical method was adapted to make it suitable as a tool for the preparation of operational concepts for a new nuclear power plant. Practical examples are provided of the systematic application of the method and the various presentation formats in the operational analysis of advanced reactors.

  1. Recent advances in chelator design and labelling methodology for (68) Ga radiopharmaceuticals.

    Burke, Benjamin P; Clemente, Gonçalo S; Archibald, Stephen J


    Gallium-68 has the potential to become the technetium-99m of positron emission tomography with ideal decay characteristics and a long-lived parent isotope for generator production. The work in the area of (68) Ga is focused on two key areas: (1) synthesis of a library of bifunctional chelators, which can be quickly radiolabelled to form kinetically inert complexes under mild conditions compatible with biomolecules and (2) development of radiosynthetic methodologies for clinical use and to facilitate radiolabelling of a wide range of chelators under mild conditions. Recent advances in these areas, with particular focus on the past 3 years, are covered herein. Copyright © 2014 John Wiley & Sons, Ltd.

  2. Current updates on diagnostic methodologies for tick-borne hemoparasitic diseases in equids: A review

    Lawan Adamu


    Full Text Available Tick-borne diseases (TBDs or otherwise called equine piroplasmosis (EP are the foremost economic limitations to equids production. Thus, reducing the breeding capability and athletic performance of equids globally. Identification of these haemoparasites is crucial in understanding their distribution in the population and it is imperative to discern between species and subspecies that are responsible for the occurrence of the disease conditions. Conventional procedures such as microscopic and serological evaluations do not usually meet these prerequisites. Diagnostic contrivances, such as the complement fixation test (CFT, the indirect fluorescent antibody test (IFAT and the enzyme linked immunosorbent assay (ELISA have been efficaciously used for many years. Furthermore, DNA-based investigations for identification, differentiation and classification of different haemoparasites have also been established. Molecular diagnostic procedures, such as DNA hybridization, polymerase chain reaction (PCR, transcriptomics, proteomics, metagenomics and metabolomics, permit the uncovering of parasites in blood, tissues or ticks with optimal sensitivity, specificity and consistency. In addition, these procedures can be exploited to detect definite species and subspecies. The prerequisite of these investigations must include proper premeditation and validation, these investigations provide an effective device for molecular studies, with greater benefits of flexibility to standardization. The application of these procedures for studying TBDs or EP globally will be irreplaceable for a long period from now. Therefore, the aim of this review is to draw up the specifics of the procedures in more convenient form for practitioners and researchers. KEY WORDS: Diagnosis, equids, molecular, transcriptomics, proteomics, metagenomics, metabolomics, haemoparasites, tick-borne diseases [J Adv Vet Anim Res 2016; 3(2.000: 84-91

  3. A methodology for Living Probabilistic Safety Assessment (LPSA) based on Advanced Control Room Operator Support System (ACROSS)

    Zubair, Muhammad, E-mail: [College of Nuclear Science and Technology, Harbin Engineering University, 145 Nantong Street, Nangang District, Harbin, Heilongjiang 150001 (China); Zhang Zhijian, E-mail: [College of Nuclear Science and Technology, Harbin Engineering University, 145 Nantong Street, Nangang District, Harbin, Heilongjiang 150001 (China); Khan, Salah Ud-din, E-mail: [College of Nuclear Science and Technology, Harbin Engineering University, 145 Nantong Street, Nangang District, Harbin, Heilongjiang 150001 (China)


    Highlights: > In this study we have introduced a methodology for Living Probabilistic Safety Assessment (LPSA). > Now the paper is focus on LPSA methodology for this purpose we introduced Advanced Control Room Operator Support System (ACROSS). > The ACROSS concept is new technique in LPSA and it's a part of our research project. > Detail is present in Section of paper. > We have also added to provide more detail about methodology. > We have remove Risk monitor portion from our paper and give more attention to LPSA methodology. - Abstract: In Probabilistic Safety Assessment (PSA) all attention is paid to analyze a system which is a time consuming effort so there is a need to develop a system network to support the analyst and to reduce manpower. To handle the physical, operational and organizational changes and to utilize the PSA information effectively the development of living Probabilistic Safety Assessment (LPSA) is essential. This paper presents a detailed methodology for LPSA. One part of this methodology is Advanced Control Room Operator Support System (ACROSS) which is helpful for updating the LPSA model. This methodology also provides help to make the control rooms in Nuclear Power Plants (NPPs) more advanced and user friendly. The study also makes recommendations for further use and development of this technique in the present and future NPPs.

  4. The Clinical Utility and Diagnostic Performance of MRI for Identification of Early and Advanced Knee Osteoarthritis: A Systematic Review

    Quatman, Carmen E.; Hettrich, Carolyn M.; Schmitt, Laura C.; Spindler, Kurt P.


    Background Current diagnostic strategies for detection of structural articular cartilage abnormalities, the earliest structural signs of osteoarthritis, often do not capture the condition until it is too far advanced for the most potential benefit of non-invasive interventions. Purpose Systematically review the literature relative to the following questions: (1) Is MRI a valid, sensitive, specific, accurate and reliable instrument to identify knee articular cartilage abnormalities compared to arthroscopy? (2) Is MRI a sensitive tool that can be utilized to identify early cartilage degeneration? Study Design Systematic Review Methods A systematic search was performed in November 2010 using PubMed MEDLINE (from 1966), CINAHL (from 1982), SPORTDiscus (from 1985), and SCOPUS (from 1996) databases. Results Fourteen level I and 13 level II studies were identified that met inclusion criteria and provided information related to diagnostic performance of MRI compared to arthroscopic evaluation. The diagnostic performance of MRI demonstrated a large range of sensitivities, specificities, and accuracies. The sensitivity for identifying articular cartilage abnormalities in the knee joint was reported between 26–96%. Specificity and accuracy was reported between 50–100% and 49–94%, respectively. The sensitivity, specificity, and accuracy for identifying early osteoarthritis were reported between 0–86%, 48–95%, and 5–94%, respectively. As a result of inconsistencies between imaging techniques and methodological shortcomings of many of the studies, a meta-analysis was not performed and it was difficult to fully synthesize the information to state firm conclusions about the diagnostic performance of MRI. Conclusions There is evidence in some MRI protocols that MRI is a relatively valid, sensitive, specific, accurate, and reliable clinical tool for identifying articular cartilage degeneration. Due to heterogeneity of MRI sequences it is not possible to make definitive

  5. Recent Advances in Characterization of Lignin Polymer by Solution-State Nuclear Magnetic Resonance (NMR Methodology

    Run-Cang Sun


    Full Text Available The demand for efficient utilization of biomass induces a detailed analysis of the fundamental chemical structures of biomass, especially the complex structures of lignin polymers, which have long been recognized for their negative impact on biorefinery. Traditionally, it has been attempted to reveal the complicated and heterogeneous structure of lignin by a series of chemical analyses, such as thioacidolysis (TA, nitrobenzene oxidation (NBO, and derivatization followed by reductive cleavage (DFRC. Recent advances in nuclear magnetic resonance (NMR technology undoubtedly have made solution-state NMR become the most widely used technique in structural characterization of lignin due to its versatility in illustrating structural features and structural transformations of lignin polymers. As one of the most promising diagnostic tools, NMR provides unambiguous evidence for specific structures as well as quantitative structural information. The recent advances in two-dimensional solution-state NMR techniques for structural analysis of lignin in isolated and whole cell wall states (in situ, as well as their applications are reviewed.




    Full Text Available An Advanced Standard Encryption Algorithm (AES is widely used in modern consumer electronicproducts for security. The IEEE 802.15.4 Low-Rate wireless sensor networks also use AES algorithm wherelow power consumption is the priority. To reduce the time taken for encryption of huge data, the algorithm hasto be implemented in hardware. To meet the requirement for low area the algorithm has to be implemented insoftware. Hence, a balance has to be achieved between hardware and software implementations in terms of areaand speed, so as to improve the overall performance of the system. Also with the co-design methodology totalthermal power dissipation is reduced. In this paper, 128 bit AES algorithm is implemented with hardware incombination with software using Altera NIOS II Processor platform. Altera’s Quartus II environment is used fordesign of the system. Cyclone II FPGA is used as a development platform. Software program is written in C language. NIOS II ntegrated Development Environment (IDE is used to integrate hardware and software together. By adopting hardware / software co-design methodology for implementation of AES, results show that a onsiderable improvement in speed can be achieved as compared to software only approach. Further, the significant reduction in area is achieved as compared to hardware only approach. By the approach of co-design an optimized design in terms of speed and area is achieved and also the thermal power dissipation is reduced

  7. Diagnostic Systems Plan for the Advanced Light Source Top-OffUpgrade

    Barry, Walter; Chin, Mike; Robin, David; Sannibale, Fernando; Scarvie, Tom; Steier, Christoph


    The Advanced Light Source (ALS) will soon be upgraded to enable top-off operations [1], in which electrons are quasi-continuously injected to produce constant stored beam current. The upgrade is structured in two phases. First, we will upgrade our injector from 1.5 GeV to 1.9 GeV to allow full energy injection and will start top-off operations. In the second phase, we will upgrade the Booster Ring (BR) with a bunch cleaning system to allow high bunch purity top-off injection. A diagnostics upgrade will be crucial for success in both phases of the top-off project, and our plan for it is described in this paper. New booster ring diagnostics will include updated beam position monitor (BPM) electronics, a tune monitoring system, and a new scraper. Two new synchrotron light monitors and a beam stop will be added to the booster-to-storage ring transfer line (BTS), and all the existing beam current monitors along the accelerator chain will be integrated into a single injection efficiency monitoring application. A dedicated bunch purity monitor will be installed in the storage ring (SR). Together, these diagnostic upgrades will enable smooth commissioning of the full energy injector and a quick transition to high quality top-off operation at the ALS.

  8. A methodology for laser diagnostics in large-bore marine two-stroke diesel engines

    Hult, J.; Mayer, S.


    Large two-stroke diesel engines for marine propulsion offer several challenges to successful implementation of the laser diagnostic techniques applied extensively in smaller automotive engines. For this purpose a fully operational large-bore engine has been modified to allow flexible optical access, through 24 optical ports with clear diameters of 40 mm. By mounting the entire optical set-up directly to the engine, effects of the vigorous vibrations and thermal drifts on alignment can be minimized. Wide-angle observation and illumination, as well as relatively large aperture detection, is made possible through mounting of optical modules and relays inside optical ports. This allows positioning of the last optical element within 10 mm from the cylinder wall. Finally, the implementation on a multi-cylinder engine allows for flexible and independent operation of the optically accessible cylinder for testing purposes. The performance of the integrated optical engine and imaging system developed is demonstrated through laser Mie scattering imaging of fuel jet structures, from which information on liquid penetration and spray angles can be deduced. Double pulse laser-sheet imaging of native in-cylinder structures is also demonstrated, for the purpose of velocimetry.

  9. Point-of-care diagnostics: an advancing sector with nontechnical issues.

    Huckle, David


    The particular reasons for the relative lack in development of point-of-care (PoC) diagnostics in a business context were discussed in our sister journal, Expert Review of Medical Devices, over 2 years ago. At that time, it could be seen that the concept of PoC testing was being revisited for at least the fifth time in the last 20 years. There had been important advances in technology but, with changes in global healthcare structures and funding, the overall in vitro diagnostics sector has had sluggish growth. Only molecular diagnostics and PoC testing are growing strongly. PoC testing is now a quarter of the total global in vitro diagnostics market, but largely due to use in diabetes monitoring. An increased focus on areas other than glucose self-testing has created a disturbance in the market. An implementation issue from this disturbance is that of control between central laboratories and the proposed sites for PoC testing. Evidence is presented to show that the first step is likely to be increased use in clinics and outpatient facilities closely linked with the laboratory. The aim will be to control the quality of the test, maintenance of equipment and provide support for the clinician in interpretation. The major problem for effective PoC implementation will be the significant changes to patient pathways that are required. The changes will benefit the patient and clinical outcomes but will require healthcare professionals to change their work patterns. This will be an uphill task!

  10. Methodological aspects of magnetic resonance tomographic diagnostics of metastatic compressive fractures of the spine

    Александр Павлович Мягков


    Full Text Available Aim of the study – to define an information value of the different pulse patterns for a qualitative estimation of MR-signals in the body of compressed vertebras.Methods: 50 patients with metastatic compressive fractures (MCF were examined using MRT. 30 (60% mans and 20 (40% woman, average age 60,8 +/- 12,5 years. Fractures in the different parts of spine were considered: cervical – 6 (12,0; thoracic – 25 (50,0 %; lumbar – 19 (38 %. Metastasis in the spine are more frequent at a cancer of mammary gland (20,0 %, kidneys (17,5 % and prostate gland (15,0 %, less frequent at a cancer of lungs, thyroid gland and sarcomas (7,5 %.MRT was done for all patients using apparatus with magnetic force 0,2, 1,5 and 0,36Т (AIRIS Mate, ECHELON of "HitachimedicalCorp.", Japan, “I-Open 0, 36” Chinein 3 projections receiving Т1-, Т2- weighted (Т1WI, Т2WI and diffusion-weighted images (DWIand also images with suppression of signals from an adipose tissue (STIR, Fat/sat.Results: the more obvious pulse patterns (PP at MCF of spine are – STIR (97,8 %, Т1WI и DWI (80 %. DWI can be used as a screening and addition for above-listed PP. The more objective criterion for a judgment about MCF is abnormal uptake of CM (60 % on diffuse type.Conclusions: for MRT visualization of MCF the most optimal are the next PP – STIR, Т1WI and DWI, with a sensitivity, respectively – 97,8 %, 80 %, and 80 %. DWI must supplement but not substitute all existing PP. On the post-contrast T1WI an objective criterion for MRT diagnostics of MCF is an abnormal uptake of CM on diffuse type. An alteration of signal characteristics in the body of compressed vertebras is an evidence of an alteration of structure, but for more precise definition of its character it is necessary to study its morphological alterations


    T. N. Mikulik


    Full Text Available The paper investigates vibro-protection conditions for “operator-chair” system of a transport facility (“Belarus-tractorfamily. Experimental  research for the system vibroloading with due account of elastic shock-absorbing characteristics, operator’s comfortability. The paper has made it possible to determine a range of the system vibration frequency which is badlysustained by the operator because the last is located in the zone of natural frequency of human visceral organs vibrationsInfluence of physiological operator’s factors – heartbeat rate, variational height, mode amplitude, stress index has been investigated on the basis of a factor experiment and correlation dependences have been obtained in the paper. The developed methodology for investigation of algorithmic provision pertaining to better active vibroprotection of the “operator-chair” system presupposes an availability of mathematical model used for synthesis of control laws and selection of algorithms for formation of signals on physiological operator’s state. Structural algorithm scheme for vibroprotection of “driver – seat – road” system has been drawn in the paper. Harmonic sinusoidal and poly-harmonic disturbances from the side of a power unit and discrete algorithms based on filtration of white noise with a linear filter and  prescribed correlation function have been accepted as a mathematical model for external environment disturbances. In case of harmonic excitation of “operator – chair” system  a force transferred to the system by a shock-absorber and also shock-absorber efficiency evaluation in the form of force transmission coefficient and vibration insulation value are estimated at decibels. Fourier’s series describes motion of the system in case of vibration forces initiated by the operation of the power unit. Piecewise-linear function describes a reaction on impact excitation of the system when final change in speed and motion

  12. The magnetic and diagnostics systems for the Advanced Photon Source self-amplified spontaneously emitting FEL

    Gluskin, E; Dejus, Roger J; Hartog, P K D; Deriy, B N; Makarov, O A; Milton, S V; Moog, E R; Ogurtsov, V I; Trakhtenberg, E; Robinson, K E; Vasserman, I B; Vinokurov, N A; Xu, S


    A self-amplified spontaneously emitting (SASE) free-electron laser (FEL) for the visible-to-ultraviolet spectral range is under construction at the Advanced Photon Source at Argonne National Laboratory. The amplifier part of the FEL consists of twelve identical 2.7-m-long sections. Each section includes a 2.4-m-long, 33-mm-period hybrid undulator, a quadrupole lens, and a set of electron beam and radiation diagnostics equipment. The undulators will operate at a fixed magnetic gap (approx. 9.3 mm) with K=3.1. The electron beam position will be monitored using capacitive beam position monitors, YAG scintillators with imaging optics, and secondary emission detectors. The spatial distribution of the photon beam will be monitored by position sensitive detectors equipped with narrow-band filters. A high-resolution spectrograph will be used to observe the spectral distribution of the FEL radiation.

  13. Summary of the British Thoracic Society guidelines for advanced diagnostic and therapeutic flexible bronchoscopy in adults.

    Du Rand, I A; Barber, P V; Goldring, J; Lewis, R A; Mandal, S; Munavvar, M; Rintoul, R C; Shah, P L; Singh, S; Slade, M G; Woolley, A


    This new guideline covers the rapidly advancing field of interventional bronchoscopy using flexible bronchoscopy. It includes the use of more complex diagnostic procedures such as endobronchial ultrasound, interventions for the relief of central airway obstruction due to malignancy and the recent development of endobronchial therapies for chronic obstructive pulmonary disease and asthma. The guideline aims to help all those who undertake flexible bronchoscopy to understand more about this important area. It also aims to inform respiratory physicians and other specialists dealing with lung cancer of the procedures possible in the management and palliation of central airway obstruction. The guideline covers transbronchial needle aspiration and endobronchial ultrasound-guided transbronchial needle aspiration, electrocautery/diathermy, argon plasma coagulation and thermal laser, cryotherapy, cryoextraction, photodynamic therapy, brachytherapy, tracheobronchial stenting, electromagnetic navigation bronchoscopy, endobronchial valves for emphysema and bronchial thermoplasty for asthma.

  14. Advanced Neuropsychological Diagnostics Infrastructure (ANDI: A Normative Database Created from Control Datasets.

    Nathalie R. de Vent


    Full Text Available In the Advanced Neuropsychological Diagnostics Infrastructure (ANDI, datasets of several research groups are combined into a single database, containing scores on neuropsychological tests from healthy participants. For most popular neuropsychological tests the quantity and range of these data surpasses that of traditional normative data, thereby enabling more accurate neuropsychological assessment. Because of the unique structure of the database, it facilitates normative comparison methods that were not feasible before, in particular those in which entire profiles of scores are evaluated. In this article, we describe the steps that were necessary to combine the separate datasets into a single database. These steps involve matching variables from multiple datasets, removing outlying values, determining the influence of demographic variables, and finding appropriate transformations to normality. Also, a brief description of the current contents of the ANDI database is given.

  15. Overview of charged-particle beam diagnostics for the advanced photon source (APS)

    Lumpkin, A. H.; Decker, G.; Kahana, E.; Patterson, D.; Sellyey, W.; Votaw, A.; Wang, X.; Chung, Y.


    Plans, prototypes, and initial test results for the charged-particle beam (e-,e+) diagnostic systems on the injector rings, their transport lines, and the storage ring for the Advanced Photon Source (APS) are presented. The APS will be a synchrotron radiation user facility with one of the world's brightest x-ray sources in the 10-keV to 100-keV regime. Its 200-MeV electron linac, 450-MeV positron linac, positron accumulator ring, 7-GeV booster synchrotron, 7-GeV storage ring, and undulator test lines will also demand the development and demonstration of key particle-beam characterization techniques over a wide range of parameter space. Some of these parameter values overlap or approach those projected for fourth generation light sources (linac-driven FELs and high brightness storage rings) as described at a recent workshop. Initial results from the diagnostics prototypes on the linac test stand operating at 45-MeV include current monitor data, beam loss monitor data, and video digitization using VME architecture.

  16. Charged-particle beam diagnostics for the Advanced Photon Source (APS)

    Lumpkin, A. H.; Decker, G.; Kahana, E.; Patterson, D.; Sellyey, W.; Wang, X.; Chung, Y.


    Plans, prototypes, and initial test results for the charged-particle beam (e-), e(+) diagnostic systems on the injector rings, their transport lines, and the storage ring for the Advanced Photon Source (APS) are presented. The APS will be a synchrotron radiation user facility with one of the world's brightest x-ray sources in the 10-keV to 100-keV regime. Its 200-MeV electron linac, 450-MeV positron linac, positron accumulator ring, 7-GeV booster synchrotron, 7-GeV storage ring, and undulator test lines will also demand the development and demonstration of key particle-beam characterization techniques over a wide range of parameter space. Some of these parameter values overlap or approach those projected for fourth generation light sources (linac-driven FELs and high brightness storage rings) as described at a recent workshop. Initial results from the diagnostics prototypes on the linac test stand operating at 45-MeV include current monitor data, beam loss monitor data, and video digitization using VME architecture.

  17. Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma

    Jakobsen, Kristine Raaby; Paulsen, Birgitte Sandfeld; Bæk, Rikke


    Background: Lung cancer is one of the leading causes of cancer-related death. At the time of diagnosis, more than half of the patients will have disseminated disease and, yet, diagnosing can be challenging. New methods are desired to improve the diagnostic work-up. Exosomes are cell-derived vesic......Background: Lung cancer is one of the leading causes of cancer-related death. At the time of diagnosis, more than half of the patients will have disseminated disease and, yet, diagnosing can be challenging. New methods are desired to improve the diagnostic work-up. Exosomes are cell...... control subjects based on the differential display of exosomal protein markers. Methods: Plasma was isolated from 109 NSCLC patients with advanced stage (IIIa–IV) disease and 110 matched control subjects initially suspected of having cancer, but diagnosed to be cancer free. The Extracellular Vesicle Array...... (EV Array) was used to phenotype exosomes directly from the plasma samples. The array contained 37 antibodies targeting lung cancer-related proteins and was used to capture exosomes, which were visualised with a cocktail of biotin-conjugated CD9, CD63 and CD81 antibodies. Results: The EV Array...

  18. Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma

    Jakobsen, Kristine R; Paulsen, Birgitte S; Bæk, Rikke


    BACKGROUND: Lung cancer is one of the leading causes of cancer-related death. At the time of diagnosis, more than half of the patients will have disseminated disease and, yet, diagnosing can be challenging. New methods are desired to improve the diagnostic work-up. Exosomes are cell-derived vesic......BACKGROUND: Lung cancer is one of the leading causes of cancer-related death. At the time of diagnosis, more than half of the patients will have disseminated disease and, yet, diagnosing can be challenging. New methods are desired to improve the diagnostic work-up. Exosomes are cell...... control subjects based on the differential display of exosomal protein markers. METHODS: Plasma was isolated from 109 NSCLC patients with advanced stage (IIIa-IV) disease and 110 matched control subjects initially suspected of having cancer, but diagnosed to be cancer free. The Extracellular Vesicle Array...... (EV Array) was used to phenotype exosomes directly from the plasma samples. The array contained 37 antibodies targeting lung cancer-related proteins and was used to capture exosomes, which were visualised with a cocktail of biotin-conjugated CD9, CD63 and CD81 antibodies. RESULTS: The EV Array...

  19. Geared rotor dynamic methodologies for advancing prognostic modeling capabilities in rotary-wing transmission systems

    Stringer, David Blake

    The overarching objective in this research is the development of a robust, rotor dynamic, physics based model of a helicopter drive train as a foundation for the prognostic modeling for rotary-wing transmissions. Rotorcrafts rely on the integrity of their drive trains for their airworthiness. Drive trains rely on gear technology for their integrity and function. Gears alter the vibration characteristics of a mechanical system and significantly contribute to noise, component fatigue, and personal discomfort prevalent in rotorcraft. This research effort develops methodologies for generating a rotor dynamic model of a rotary-wing transmission based on first principles, through (i) development of a three-dimensional gear-mesh stiffness model for helical and spur gears and integration of this model in a finite element rotor dynamic model, (ii) linear and nonlinear analyses of a geared system for comparison and validation of the gear-mesh model, (iii) development of a modal synthesis technique for potentially providing model reduction and faster analysis capabilities for geared systems, and (iv) extension of the gear-mesh model to bevel and epicyclic configurations. In addition to model construction and validation, faults indigenous to geared systems are presented and discussed. Two faults are selected for analysis and seeded into the transmission model. Diagnostic vibration parameters are presented and used as damage indicators in the analysis. The fault models produce results consistent with damage experienced during experimental testing. The results of this research demonstrate the robustness of the physics-based approach in simulating multiple normal and abnormal conditions. The advantages of this physics-based approach, when combined with contemporary probabilistic and time-series techniques, provide a useful method for improving health monitoring technologies in mechanical systems.

  20. Affinity-based methodologies and ligands for antibody purification: advances and perspectives.

    Roque, Ana C A; Silva, Cláudia S O; Taipa, M Angela


    Many successful, recent therapies for life-threatening diseases such as cancer and rheumatoid arthritis are based on the recognition between native or genetically engineered antibodies and cell-surface receptors. Although naturally produced by the immune system, the need for antibodies with unique specificities and designed for single application, has encouraged the search for novel antibody purification strategies. The availability of these products to the end-consumer is strictly related to manufacture costs, particularly those attributed to downstream processing. Over the last decades, academia and industry have developed different types of interactions and separation techniques for antibody purification, affinity-based strategies being the most common and efficient methodologies. The affinity ligands utilized range from biological to synthetic designed molecules with enhanced resistance and stability. Despite the successes achieved, the purification "paradigm" still moves interests and efforts in the continuous demand for improved separation performances. This review will focus on recent advances and perspectives in antibody purification by affinity interactions using different techniques, with particular emphasis on affinity chromatography.

  1. Advanced Raman Spectroscopy of Methylammonium Lead Iodide: Development of a Non-destructive Characterisation Methodology

    Pistor, Paul; Ruiz, Alejandro; Cabot, Andreu; Izquierdo-Roca, Victor


    In recent years, there has been an impressively fast technological progress in the development of highly efficient lead halide perovskite solar cells. However, the stability of perovskite films and respective solar cells is still an open point of concern and calls for advanced characterization methods. In this work, we identify appropriate measurement conditions for a meaningful analysis of spin-coated absorber-grade perovskite thin films based on methylammonium (MA) lead iodide (MAPbI3) by Raman spectroscopy. The material under investigation and its derivates is the most commonly used for high efficiency devices in the literatures and has yielded working solar cell devices with efficiencies around 10% in our laboratory. We report highly detailed Raman spectra obtained with excitation at 532 nm and 633 nm and their deconvolution taking advantage of the simultaneous fitting of spectra obtained with varying excitation wavelengths. Finally, we propose a fast and contactless methodology based on Raman to probe composition variations and/or degradation of these perovskite thin films and discuss the potential of the presented technique as quality control and degradation monitoring tool in other organic-inorganic perovskite materials and complete solar cell devices.

  2. Body image in Brazil: recent advances in the state of knowledge and methodological issues

    Laus, Maria Fernanda; Kakeshita, Idalina Shiraishi; Costa, Telma Maria Braga; Ferreira, Maria Elisa Caputo; Fortes, Leonardo de Sousa; Almeida, Sebastião Sousa


    OBJECTIVE To analyze Brazilian literature on body image and the theoretical and methodological advances that have been made. METHODS A detailed review was undertaken of the Brazilian literature on body image, selecting published articles, dissertations and theses from the SciELO, SCOPUS, LILACS and PubMed databases and the CAPES thesis database. Google Scholar was also used. There was no start date for the search, which used the following search terms: “body image” AND “Brazil” AND “scale(s)”; “body image” AND “Brazil” AND “questionnaire(s)”; “body image” AND “Brazil” AND “instrument(s)”; “body image” limited to Brazil and “body image”. RESULTS The majority of measures available were intended to be used in college students, with half of them evaluating satisfaction/dissatisfaction with the body. Females and adolescents of both sexes were the most studied population. There has been a significant increase in the number of available instruments. Nevertheless, numerous published studies have used non-validated instruments, with much confusion in the use of the appropriate terms (e.g., perception, dissatisfaction, distortion). CONCLUSIONS Much more is needed to understand body image within the Brazilian population, especially in terms of evaluating different age groups and diversifying the components/dimensions assessed. However, interest in this theme is increasing, and important steps have been taken in a short space of time. PMID:24897056

  3. A Methodology for Loading the Advanced Test Reactor Driver Core for Experiment Analysis

    Cowherd, Wilson M.; Nielsen, Joseph W.; Choe, Dong O.


    In support of experiments in the ATR, a new methodology was devised for loading the ATR Driver Core. This methodology will replace the existing methodology used by the INL Neutronic Analysis group to analyze experiments. Studied in this paper was the as-run analysis for ATR Cycle 152B, specifically comparing measured lobe powers and eigenvalue calculations.

  4. Advanced radiochromic film methodologies for quantitative dosimetry of small and nonstandard fields

    Rosen, Benjamin S.

    Radiotherapy treatments with small and nonstandard fields are increasing in use as collimation and targeting become more advanced, which spare normal tissues while increasing tumor dose. However, dosimetry of small and nonstandard fields is more difficult than that of conventional fields due to loss of lateral charged-particle equilibrium, tight measurement setup requirements, source occlusion, and the volume-averaging effect of conventional dosimeters. This work aims to create new small and nonstandard field dosimetry protocols using radiochromic film (RCF) in conjunction with novel readout and analysis methodologies. It also is the intent of this work to develop an improved understanding of RCF structure and mechanics for its quantitative use in general applications. Conventional digitization techniques employ white-light, flatbed document scanners or scanning-laser densitometers which are not optimized for RCF dosimetry. A point-by-point precision laser densitometry system (LDS) was developed for this work to overcome the film-scanning artifacts associated with the use of conventional digitizers, such as positional scan dependence, off-axis light scatter, glass bed interference, and low signal-to-noise ratios. The LDS was shown to be optically traceable to national standards and to provide highly reproducible density measurements. Use of the LDS resulted in increased agreement between RCF dose measurements and the single-hit detector model of film response, facilitating traceable RCF calibrations based on calibrated physical quantities. GafchromicRTM EBT3 energy response to a variety of reference x-ray and gamma-ray beam qualities was also investigated. Conventional Monte Carlo methods are not capable of predicting film intrinsic energy response to arbitrary particle spectra. Therefore, a microdosimetric model was developed to simulate the underlying physics of the radiochromic mechanism and was shown to correctly predict the intrinsic response relative to a

  5. Integrated methodological frameworks for modelling agent-based advanced supply chain planning systems: A systematic literature review

    Luis Antonio Santa-Eulalia


    Full Text Available Purpose: The objective of this paper is to provide a systematic literature review of recent developments in methodological frameworks for the modelling and simulation of agent-based advanced supply chain planning systems.Design/methodology/approach: A systematic literature review is provided to identify, select and make an analysis and a critical summary of all suitable studies in the area. It is organized into two blocks: the first one covers agent-based supply chain planning systems in general terms, while the second one specializes the previous search to identify those works explicitly containing methodological aspects.Findings: Among sixty suitable manuscripts identified in the primary literature search, only seven explicitly considered the methodological aspects. In addition, we noted that, in general, the notion of advanced supply chain planning is not considered unambiguously, that the social and individual aspects of the agent society are not taken into account in a clear manner in several studies and that a significant part of the works are of a theoretical nature, with few real-scale industrial applications. An integrated framework covering all phases of the modelling and simulation process is still lacking in the literature visited.Research limitations/implications: The main research limitations are related to the period covered (last four years, the selected scientific databases, the selected language (i.e. English and the use of only one assessment framework for the descriptive evaluation part.Practical implications: The identification of recent works in the domain and discussion concerning their limitations can help pave the way for new and innovative researches towards a complete methodological framework for agent-based advanced supply chain planning systems.Originality/value: As there are no recent state-of-the-art reviews in the domain of methodological frameworks for agent-based supply chain planning, this paper contributes to

  6. Structured syncope care pathways based on lean six sigma methodology optimises resource use with shorter time to diagnosis and increased diagnostic yield.

    Martens, Leon; Goode, Grahame; Wold, Johan F H; Beck, Lionel; Martin, Georgina; Perings, Christian; Stolt, Pelle; Baggerman, Lucas


    To conduct a pilot study on the potential to optimise care pathways in syncope/Transient Loss of Consciousness management by using Lean Six Sigma methodology while maintaining compliance with ESC and/or NICE guidelines. Five hospitals in four European countries took part. The Lean Six Sigma methodology consisted of 3 phases: 1) Assessment phase, in which baseline performance was mapped in each centre, processes were evaluated and a new operational model was developed with an improvement plan that included best practices and change management; 2) Improvement phase, in which optimisation pathways and standardised best practice tools and forms were developed and implemented. Staff were trained on new processes and change-management support provided; 3) Sustaining phase, which included support, refinement of tools and metrics. The impact of the implementation of new pathways was evaluated on number of tests performed, diagnostic yield, time to diagnosis and compliance with guidelines. One hospital with focus on geriatric populations was analysed separately from the other four. With the new pathways, there was a 59% reduction in the average time to diagnosis (p = 0.048) and a 75% increase in diagnostic yield (p = 0.007). There was a marked reduction in repetitions of diagnostic tests and improved prioritisation of indicated tests. Applying a structured Lean Six Sigma based methodology to pathways for syncope management has the potential to improve time to diagnosis and diagnostic yield.

  7. Structured syncope care pathways based on lean six sigma methodology optimises resource use with shorter time to diagnosis and increased diagnostic yield.

    Leon Martens

    Full Text Available To conduct a pilot study on the potential to optimise care pathways in syncope/Transient Loss of Consciousness management by using Lean Six Sigma methodology while maintaining compliance with ESC and/or NICE guidelines.Five hospitals in four European countries took part. The Lean Six Sigma methodology consisted of 3 phases: 1 Assessment phase, in which baseline performance was mapped in each centre, processes were evaluated and a new operational model was developed with an improvement plan that included best practices and change management; 2 Improvement phase, in which optimisation pathways and standardised best practice tools and forms were developed and implemented. Staff were trained on new processes and change-management support provided; 3 Sustaining phase, which included support, refinement of tools and metrics. The impact of the implementation of new pathways was evaluated on number of tests performed, diagnostic yield, time to diagnosis and compliance with guidelines. One hospital with focus on geriatric populations was analysed separately from the other four.With the new pathways, there was a 59% reduction in the average time to diagnosis (p = 0.048 and a 75% increase in diagnostic yield (p = 0.007. There was a marked reduction in repetitions of diagnostic tests and improved prioritisation of indicated tests.Applying a structured Lean Six Sigma based methodology to pathways for syncope management has the potential to improve time to diagnosis and diagnostic yield.

  8. Edge multi-energy soft x-ray diagnostic in Experimental Advanced Superconducting Tokamak

    Li, Y. L.; Xu, G. S.; Tritz, K.; Zhu, Y. B.; Wan, B. N.; Lan, H.; Liu, Y. L.; Wei, J.; Zhang, W.; Hu, G. H.; Wang, H. Q.; Duan, Y. M.; Zhao, J. L.; Wang, L.; Liu, S. C.; Ye, Y.; Li, J.; Lin, X.; Li, X. L.


    A multi-energy soft x-ray (ME-SXR) diagnostic has been built for electron temperature profile in the edge plasma region in Experimental Advanced Superconducting Tokamak (EAST) after two rounds of campaigns. Originally, five preamplifiers were mounted inside the EAST vacuum vessel chamber attached to five vertically stacked compact diode arrays. A custom mechanical structure was designed to protect the detectors and electronics under constraints of the tangential field of view for plasma edge and the allocation of space. In the next experiment, the mechanical structure was redesigned with a barrel structure to absolutely isolate it from the vacuum vessel. Multiple shielding structures were mounted at the pinhole head to protect the metal foils from lithium coating. The pre-amplifiers were moved to the outside of the vacuum chamber to avoid introducing interference. Twisted copper cooling tube was embedded into the back-shell near the diode to limit the temperature of the preamplifiers and diode arrays during vacuum vessel baking when the temperature reached 150 °C. Electron temperature profiles were reconstructed from ME-SXR measurements using neural networks.

  9. Edge multi-energy soft x-ray diagnostic in Experimental Advanced Superconducting Tokamak

    Li, Y. L.; Xu, G. S.; Wan, B. N.; Lan, H.; Liu, Y. L.; Wei, J.; Zhang, W.; Hu, G. H.; Wang, H. Q.; Duan, Y. M.; Zhao, J. L.; Wang, L.; Liu, S. C.; Ye, Y.; Li, J.; Lin, X.; Li, X. L. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Tritz, K. [Department of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218 (United States); Zhu, Y. B. [Department of Physics and Astronomy, University of California, Irvine, California 92697-4575 (United States)


    A multi-energy soft x-ray (ME-SXR) diagnostic has been built for electron temperature profile in the edge plasma region in Experimental Advanced Superconducting Tokamak (EAST) after two rounds of campaigns. Originally, five preamplifiers were mounted inside the EAST vacuum vessel chamber attached to five vertically stacked compact diode arrays. A custom mechanical structure was designed to protect the detectors and electronics under constraints of the tangential field of view for plasma edge and the allocation of space. In the next experiment, the mechanical structure was redesigned with a barrel structure to absolutely isolate it from the vacuum vessel. Multiple shielding structures were mounted at the pinhole head to protect the metal foils from lithium coating. The pre-amplifiers were moved to the outside of the vacuum chamber to avoid introducing interference. Twisted copper cooling tube was embedded into the back-shell near the diode to limit the temperature of the preamplifiers and diode arrays during vacuum vessel baking when the temperature reached 150 °C. Electron temperature profiles were reconstructed from ME-SXR measurements using neural networks.

  10. Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma

    Kristine R. Jakobsen


    Full Text Available Background: Lung cancer is one of the leading causes of cancer-related death. At the time of diagnosis, more than half of the patients will have disseminated disease and, yet, diagnosing can be challenging. New methods are desired to improve the diagnostic work-up. Exosomes are cell-derived vesicles displaying various proteins on their membrane surfaces. In addition, they are readily available in blood samples where they constitute potential biomarkers of human diseases, such as cancer. Here, we examine the potential of distinguishing non-small cell lung carcinoma (NSCLC patients from control subjects based on the differential display of exosomal protein markers. Methods: Plasma was isolated from 109 NSCLC patients with advanced stage (IIIa–IV disease and 110 matched control subjects initially suspected of having cancer, but diagnosed to be cancer free. The Extracellular Vesicle Array (EV Array was used to phenotype exosomes directly from the plasma samples. The array contained 37 antibodies targeting lung cancer-related proteins and was used to capture exosomes, which were visualised with a cocktail of biotin-conjugated CD9, CD63 and CD81 antibodies. Results: The EV Array analysis was capable of detecting and phenotyping exosomes in all samples from only 10 µL of unpurified plasma. Multivariate analysis using the Random Forests method produced a combined 30-marker model separating the two patient groups with an area under the curve of 0.83, CI: 0.77–0.90. The 30-marker model has a sensitivity of 0.75 and a specificity of 0.76, and it classifies patients with 75.3% accuracy. Conclusion: The EV Array technique is a simple, minimal-invasive tool with potential to identify lung cancer patients.

  11. Diagnostic suite of the C-2U advanced beam-driven field-reversed configuration plasma experiment

    Thompson, M. C.; Gota, H.; Putvinski, S.; Tuszewski, M.; Binderbauer, M.


    The C-2U experiment at Tri Alpha Energy studies the evolution of field-reversed configuration (FRC) plasmas sustained by neutral beam injection. Data on the FRC plasma performance are provided by a comprehensive suite of diagnostics that includes magnetic sensors, interferometry, Thomson scattering, spectroscopy, bolometry, reflectometry, neutral particle analyzers, and fusion product detectors. While many of these diagnostic systems were inherited from the preceding experiment C-2, C-2U has a variety of new and upgraded diagnostic systems: multi-chord far-infrared polarimetry, multiple fast imaging cameras with selectable atomic line filters, proton detector arrays, and 100 channel bolometer units capable of observing multiple regions of the spectrum simultaneously. In addition, extensive ongoing work focuses on advanced methods of measuring separatrix shape and plasma current profile that will facilitate equilibrium reconstruction and active control of the FRC plasma.

  12. Diagnostic suite of the C-2U advanced beam-driven field-reversed configuration plasma experiment

    Thompson, M. C., E-mail:; Gota, H.; Putvinski, S.; Tuszewski, M.; Binderbauer, M. [Tri Alpha Energy, Inc., Rancho Santa Margarita, California 92688 (United States)


    The C-2U experiment at Tri Alpha Energy studies the evolution of field-reversed configuration (FRC) plasmas sustained by neutral beam injection. Data on the FRC plasma performance are provided by a comprehensive suite of diagnostics that includes magnetic sensors, interferometry, Thomson scattering, spectroscopy, bolometry, reflectometry, neutral particle analyzers, and fusion product detectors. While many of these diagnostic systems were inherited from the preceding experiment C-2, C-2U has a variety of new and upgraded diagnostic systems: multi-chord far-infrared polarimetry, multiple fast imaging cameras with selectable atomic line filters, proton detector arrays, and 100 channel bolometer units capable of observing multiple regions of the spectrum simultaneously. In addition, extensive ongoing work focuses on advanced methods of measuring separatrix shape and plasma current profile that will facilitate equilibrium reconstruction and active control of the FRC plasma.

  13. Acute myeloid leukemia in the era of precision medicine:recent advances in diagnostic classification and risk stratification

    Rina Kansal


    Acute myeloid leukemia (AML) is a genetically heterogeneous myeloid malignancy that occurs more commonly in adults, and has an increasing incidence, most likely due to increasing age. Precise diagnostic classification of AML requires clinical and pathologic information, the latter including morphologic, immunophenotypic, cytogenetic and molecular genetic analysis. Risk stratification in AML requires cytogenetics evaluation as the most important predictor, with genetic mutations providing additional necessary information. AML with normal cytogenetics comprises about 40%-50% of all AML, and has been intensively investigated. The currently used 2008 World Health Organization classification of hematopoietic neoplasms has been proposed to be updated in 2016, also to include an update on the classification of AML, due to the continuously increasing application of genomic techniques that have led to major advances in our knowledge of the pathogenesis of AML. The purpose of this review is to describe some of these recent major advances in the diagnostic classification and risk stratification of AML.

  14. X-ray Diffraction and Multi-Frame Phase Contrast Imaging Diagnostics for IMPULSE at the Advanced Photon Source

    Iverson, Adam [National Security Technologies, LLC; Carlson, Carl [National Security Technologies, LLC; Young, Jason [National Security Technologies, LLC; Curtis, Alden [National Security Technologies, LLC; Jensen, Brian [Los Alamos National Laboratory; Ramos, Kyle [Los Alamos National Laboratory; Yeager, John [Los Alamos National Laboratory; Montgomery, David [Los Alamos National Laboratory; Fezza, Kamel [Argonne National Laboratory


    The diagnostic needs of any dynamic loading platform present unique technical challenges that must be addressed in order to accurately measure in situ material properties in an extreme environment. The IMPULSE platform (IMPact system for Ultrafast Synchrotron Experiments) at the Advanced Photon Source (APS) is no exception and, in fact, may be more challenging, as the imaging diagnostics must be synchronized to both the experiment and the 60 ps wide x-ray bunches produced at APS. The technical challenges of time-resolved x-ray diffraction imaging and high-resolution multi-frame phase contrast imaging (PCI) are described in this paper. Example data from recent IMPULSE experiments are shown to illustrate the advances and evolution of these diagnostics with a focus on comparing the performance of two intensified CCD cameras and their suitability for multi-frame PCI. The continued development of these diagnostics is fundamentally important to IMPULSE and many other loading platforms and will benefit future facilities such as the Dynamic Compression Sector at APS and MaRIE at Los Alamos National Laboratory.

  15. 75 FR 15443 - Advancing the Development of Diagnostic Tests and Biomarkers for Tuberculosis; Public Workshop...


    ...-resistant TB (MDR TB) and extensively drug-resistant TB (XDR TB). Both plans addressed domestic and global... of Diagnostic Tests and Biomarkers for Tuberculosis (TB).'' The purpose of the workshop is to provide... and procedural gaps in the current development of TB diagnostic tests, and in exploring models...

  16. Methodology Development and Physical Organic Chemistry: A Powerful Combination for the Advancement of Glycochemistry

    Crich, David


    This perspective article outlines work in the Crich group on the diastereoselective synthesis of the so-called difficult classes of glycosidic bond; the 2-deoxy-β-glycopyranosides, the β-mannopyranosides, the α-sialosides, the α-glucopyranosides and the β-arabinofuranosides with an emphasis on the critical interplay between mechanism and methodology development. PMID:21919522

  17. Building wind design methodology for Italian climatic areas (second report). Advancement

    Ciolfi, A. [UTS Engineering, Roma (Italy)


    The present work, carried out through information of the Meteorological Service of the Italian Military Aeronautic, is the first step to carry out a bioclimatic design methodology based on monitored statistical dates of wind characteristics in Italian climatic areas. The first dates obtained are relative to climatic areas of littoral latium and middle interland and they are: Pratica di Mare, Fiumicino, Ciampino, Guidonia. (orig.)

  18. Advanced software development workstation: Object-oriented methodologies and applications for flight planning and mission operations

    Izygon, Michel


    The work accomplished during the past nine months in order to help three different organizations involved in Flight Planning and in Mission Operations systems, to transition to Object-Oriented Technology, by adopting one of the currently most widely used Object-Oriented analysis and Design Methodology is summarized.

  19. A fault diagnosis methodology for rolling element bearings based on advanced signal pretreatment and autoregressive modelling

    Al-Bugharbee, Hussein; Trendafilova, Irina


    This study proposes a methodology for rolling element bearings fault diagnosis which gives a complete and highly accurate identification of the faults present. It has two main stages: signals pretreatment, which is based on several signal analysis procedures, and diagnosis, which uses a pattern-recognition process. The first stage is principally based on linear time invariant autoregressive modelling. One of the main contributions of this investigation is the development of a pretreatment signal analysis procedure which subjects the signal to noise cleaning by singular spectrum analysis and then stationarisation by differencing. So the signal is transformed to bring it close to a stationary one, rather than complicating the model to bring it closer to the signal. This type of pretreatment allows the use of a linear time invariant autoregressive model and improves its performance when the original signals are non-stationary. This contribution is at the heart of the proposed method, and the high accuracy of the diagnosis is a result of this procedure. The methodology emphasises the importance of preliminary noise cleaning and stationarisation. And it demonstrates that the information needed for fault identification is contained in the stationary part of the measured signal. The methodology is further validated using three different experimental setups, demonstrating very high accuracy for all of the applications. It is able to correctly classify nearly 100 percent of the faults with regard to their type and size. This high accuracy is the other important contribution of this methodology. Thus, this research suggests a highly accurate methodology for rolling element bearing fault diagnosis which is based on relatively simple procedures. This is also an advantage, as the simplicity of the individual processes ensures easy application and the possibility for automation of the entire process.

  20. Recent advance in target diagnostics on the Laser MégaJoule (LMJ)

    Caillaud, T.; Alozy, E.; Briat, M.; Cornet, P.; Darbon, S.; Dizière, A.; Duval, A.; Drouet, V.; Fariaut, J.; Gontier, D.; Landoas, O.; Marchet, B.; Masclet-Gobain, I.; Oudot, G.; Soullié, G.; Stemmler, P.; Reverdin, C.; Rosch, R.; Rousseau, A.; Rossé, B.; Rubbelynck, C.; Troussel, P.; Villette, B.; Aubard, F.; Huelvan, S.; Maroni, R.; Llavador, P.; Allouche, V.; Burillo, M.; Chollet, C.; D'Hose, C.; Prat, B.; Trosseille, C.; Raimbourg, J.; Zuber, C.; Lebreton, J. P.; Perez, S.; Ulmer, J. L.; Jalinaud, T.; Jadaud, J. P.; Bourgade, J. L.; Wrobel, R.; Rogue, X.; Miquel, J. L.


    Since the first experimental campaign conducted in 2014 with mid field Gated X-ray Imager (GXI) and two quadruplets (20 kJ at 351 nm) focused on target, the Laser MégaJoule (LMJ) operational capability is still growing up. New plasma diagnostics have been implemented: a large field 2D GXI, two broadband x-ray spectrometers (called DMX and miniDMX), a specific soft x-ray spectrometer and a Laser Entrance Hole (LEH) imaging diagnostic. A series of experiments have been performed leading to more than 60 shots on target. We will present the plasma diagnostics development status conducted at CEA for experimental purpose. Several diagnostics are now under manufacturing or development which include a Streaked Soft X-ray Imager (SSXI), an Equation Of State (EOS) diagnostic suite ("EOS pack"), a Full Aperture BackScattering (FABS) diagnostic, a Near Backscattered Imager (NBI), a high resolution 2D GXI, a high resolution x-ray spectrometer, a specific set of two polar hard x-ray imagers for LEH characterization and a set of Neutron Time of Flight (NTOF) detectors. We describe here the diagnostics design and performances in terms of spatial, temporal and spectral resolutions. Their designs have taken into account the harsh environment (neutron yields, gamma rays, electromagnetic perturbations, debris and shrapnel) and the safety requirements.

  1. A Design Heritage-Based Forecasting Methodology for Risk Informed Management of Advanced Systems

    Maggio, Gaspare; Fragola, Joseph R.


    The development of next generation systems often carries with it the promise of improved performance, greater reliability, and reduced operational costs. These expectations arise from the use of novel designs, new materials, advanced integration and production technologies intended for functionality replacing the previous generation. However, the novelty of these nascent technologies is accompanied by lack of operational experience and, in many cases, no actual testing as well. Therefore some of the enthusiasm surrounding most new technologies may be due to inflated aspirations from lack of knowledge rather than actual future expectations. This paper proposes a design heritage approach for improved reliability forecasting of advanced system components. The basis of the design heritage approach is to relate advanced system components to similar designs currently in operation. The demonstrated performance of these components could then be used to forecast the expected performance and reliability of comparable advanced technology components. In this approach the greater the divergence of the advanced component designs from the current systems the higher the uncertainty that accompanies the associated failure estimates. Designers of advanced systems are faced with many difficult decisions. One of the most common and more difficult types of these decisions are those related to the choice between design alternatives. In the past decision-makers have found these decisions to be extremely difficult to make because they often involve the trade-off between a known performing fielded design and a promising paper design. When it comes to expected reliability performance the paper design always looks better because it is on paper and it addresses all the know failure modes of the fielded design. On the other hand there is a long, and sometimes very difficult road, between the promise of a paper design and its fulfillment; with the possibility that sometimes the reliability

  2. Recent advances in combination of capillary electrophoresis with mass spectrometry: methodology and theory.

    Klepárník, Karel


    This review focuses on the latest development of microseparation electromigration methods in capillaries and microfluidic devices with MS detection and identification. A wide selection of 183 relevant articles covers the literature published from June 2012 till May 2014 as a continuation of the review article on the same topic by Kleparnik [Electrophoresis 2013, 34, 70-86]. Special attention is paid to the new improvements in the theory of instrumentation and methodology of MS interfacing with capillary versions of zone electrophoresis, ITP, and IEF. Ionization methods in MS include ESI, MALDI, and ICP. Although the main attention is paid to the development of instrumentation and methodology, representative examples illustrate also applications in the proteomics, glycomics, metabolomics, biomarker research, forensics, pharmacology, food analysis, and single-cell analysis. The combinations of MS with capillary versions of electrochromatography and micellar electrokinetic chromatography are not included.

  3. Transformation of theoretical-methodological approaches and methodical tools of the individual and territory welfare diagnostics. Part 1. From spreading to the alternative diagnostics approaches (background

    Aleksandr Anatolyevich Kuklin


    Full Text Available This article presents an evolution of theoretical and methodological approaches to the welfare study. Existing theories of wellbeing are grouped according to accounted method of goods and resources distribution among society members. As a welfare future as a category we highlight objective (measured and subjective (estimated components. Based on the analysis of scientific literature we determine the ratio of individual and social welfare. The main differences between the categories of “ welfare” and “wealth” are given. The main difference consists in multidirectional changes of welfare and wealth for an increase (decrease in income of the individual (country. In this article we present an analysis of modern approaches to the definition of welfare: state, institutional and expendable approach. The welfare level estimation is complicated due to the need to consider the subjective component. The article provides an analysis of existing approaches to quantitative welfare evaluation ranging from the most common techniques (HDI, GDP to alternative techniques (Happy Planet Index.Methodological devices are structured by levels of welfare assessment objects (world, country, region, people. Based on the analysis of the advantages and disadvantages of methods we can conclude that the most reliable method is a comprehensive approach, which includes economic, environmental, social, vital and infrastructure indicators. The author’s approach to the formation of a complex methodological tool for individual and territory welfare estimation is presented in this article.

  4. Life prediction methodology for ceramic components of advanced vehicular heat engines: Volume 1. Final report

    Khandelwal, P.K.; Provenzano, N.J.; Schneider, W.E. [Allison Engine Co., Indianapolis, IN (United States)


    One of the major challenges involved in the use of ceramic materials is ensuring adequate strength and durability. This activity has developed methodology which can be used during the design phase to predict the structural behavior of ceramic components. The effort involved the characterization of injection molded and hot isostatic pressed (HIPed) PY-6 silicon nitride, the development of nondestructive evaluation (NDE) technology, and the development of analytical life prediction methodology. Four failure modes are addressed: fast fracture, slow crack growth, creep, and oxidation. The techniques deal with failures initiating at the surface as well as internal to the component. The life prediction methodology for fast fracture and slow crack growth have been verified using a variety of confirmatory tests. The verification tests were conducted at room and elevated temperatures up to a maximum of 1371 {degrees}C. The tests involved (1) flat circular disks subjected to bending stresses and (2) high speed rotating spin disks. Reasonable correlation was achieved for a variety of test conditions and failure mechanisms. The predictions associated with surface failures proved to be optimistic, requiring re-evaluation of the components` initial fast fracture strengths. Correlation was achieved for the spin disks which failed in fast fracture from internal flaws. Time dependent elevated temperature slow crack growth spin disk failures were also successfully predicted.

  5. A Methodology for the Integration of a Mechanistic Source Term Analysis in a Probabilistic Framework for Advanced Reactors

    Grabaskas, Dave; Brunett, Acacia J.; Bucknor, Matthew


    GE Hitachi Nuclear Energy (GEH) and Argonne National Laboratory are currently engaged in a joint effort to modernize and develop probabilistic risk assessment (PRA) techniques for advanced non-light water reactors. At a high level, the primary outcome of this project will be the development of next-generation PRA methodologies that will enable risk-informed prioritization of safety- and reliability-focused research and development, while also identifying gaps that may be resolved through additional research. A subset of this effort is the development of PRA methodologies to conduct a mechanistic source term (MST) analysis for event sequences that could result in the release of radionuclides. The MST analysis seeks to realistically model and assess the transport, retention, and release of radionuclides from the reactor to the environment. The MST methods developed during this project seek to satisfy the requirements of the Mechanistic Source Term element of the ASME/ANS Non-LWR PRA standard. The MST methodology consists of separate analysis approaches for risk-significant and non-risk significant event sequences that may result in the release of radionuclides from the reactor. For risk-significant event sequences, the methodology focuses on a detailed assessment, using mechanistic models, of radionuclide release from the fuel, transport through and release from the primary system, transport in the containment, and finally release to the environment. The analysis approach for non-risk significant event sequences examines the possibility of large radionuclide releases due to events such as re-criticality or the complete loss of radionuclide barriers. This paper provides details on the MST methodology, including the interface between the MST analysis and other elements of the PRA, and provides a simplified example MST calculation for a sodium fast reactor.

  6. Methodological advances in unit cost calculation of psychiatric residential care in Spain.

    Moreno, Karen; Sanchez, Eduardo; Salvador-Carulla, Luis


    The care of the severe mentally ill who need intensive support for their daily living (dependent persons), accounts for an increasingly large proportion of public expenditure in many European countries. The main aim of this study was the design and implementation of solid methodology to calculate unit costs of different types of care. To date, methodologies used in Spain have produced inaccurate figures, suggesting few variations in patient consumption of the same service. An adaptation of the Activity-Based-Costing methodology was applied in Navarre, a region in the North of Spain, as a pilot project for the public mental health services. A unit cost per care process was obtained for all levels of care considered in each service during 2005. The European Service Mapping Schedule (ESMS) codes were used to classify the services for later comparisons. Finally, in order to avoid problems of asymmetric cost distribution, a simple Bayesian model was used. As an illustration, we report the results obtained for long-term residential care and note that there are important variations between unit costs when considering different levels of care. Considering three levels of care (Level 1-low, Level 2-medium and Level 3-intensive), the cost per bed in Level 3 was 10% higher than that of Level 2. The results obtained using the cost methodology described provide more useful information than those using conventional methods, although its implementation requires much time to compile the necessary information during the initial stages and the collaboration of staff and managers working in the services. However, in some services, if no important variations exist in patient care, another method would be advisable, although our system provides very useful information about patterns of care from a clinical point of view. Detailed work is required at the beginning of the implementation in order to avoid the calculation of distorted figures and to improve the levels of decision making

  7. Recent advances in salivary cancer diagnostics enabled by biosensors and bioelectronics.

    Mishra, Saswat; Saadat, Darius; Kwon, Ohjin; Lee, Yongkuk; Choi, Woon-Seop; Kim, Jong-Hoon; Yeo, Woon-Hong


    There is a high demand for a non-invasive, rapid, and highly accurate tool for disease diagnostics. Recently, saliva based diagnostics for the detection of specific biomarkers has drawn significant attention since the sample extraction is simple, cost-effective, and precise. Compared to blood, saliva contains a similar variety of DNA, RNA, proteins, metabolites, and microbiota that can be compiled into a multiplex of cancer detection markers. The salivary diagnostic method holds great potential for early-stage cancer diagnostics without any complicated and expensive procedures. Here, we review various cancer biomarkers in saliva and compare the biomarkers efficacy with traditional diagnostics and state-of-the-art bioelectronics. We summarize biomarkers in four major groups: genomics, transcriptomics, proteomics, and metabolomics/microbiota. Representative bioelectronic systems for each group are summarized based on various stages of a cancer. Systematic study of oxidative stress establishes the relationship between macromolecules and cancer biomarkers in saliva. We also introduce the most recent examples of salivary diagnostic electronics based on nanotechnologies that can offer rapid, yet highly accurate detection of biomarkers. A concluding section highlights areas of opportunity in the further development and applications of these technologies.

  8. Advancing Sexuality Studies: A Short Course on Sexuality Theory and Research Methodologies

    Fletcher, Gillian; Dowsett, Gary W.; Duncan, Duane; Slavin, Sean; Corboz, Julienne


    Critical Sexuality Studies is an emerging field of academic enquiry linked to an international network of advocacy agencies, activists, and political issues. This paper reports on the development of an advanced short course in sexuality theory and research, drawing on Critical Sexuality Studies and aiming directly at academics in developing…

  9. Advancing Sexuality Studies: A Short Course on Sexuality Theory and Research Methodologies

    Fletcher, Gillian; Dowsett, Gary W.; Duncan, Duane; Slavin, Sean; Corboz, Julienne


    Critical Sexuality Studies is an emerging field of academic enquiry linked to an international network of advocacy agencies, activists, and political issues. This paper reports on the development of an advanced short course in sexuality theory and research, drawing on Critical Sexuality Studies and aiming directly at academics in developing…

  10. New methods, new methodology: Advanced CFD in the Snecma turbomachinery design process

    Vuillez, Christophe; Petot, Bertrand


    CFD tools represent a significant source of improvements in the design process of turbomachinery components, leading to higher performances, cost and cycle savings as well as lower associated risks. Such methods are the backbone of compressor and turbine design methodologies at Snecma. In the 80's, the use of 3D Euler solvers was a key factor in designing fan blades with very high performance level. Counter rotating high speed propellers designed with this methodology reached measured performances very close to their ambitious objective from the first test series. In the late 80's and the beginning of the 90's, new, more powerful methods were rapidly developed and are now commonly used in the design process: a quasi-3D, compressible, transonic inverse method; quasi-3D and 3D Navier-Stokes solvers; 3D unsteady Euler solvers. As an example, several hundred 3D Navier-Stokes computations are run yearly for the design of low and high pressure compressor and turbine blades. In addition to their modelling capabilities, the efficient use of such methods in the design process comes from their close integration in the global methodology and from an adequate exploitation environment. Their validation, their calibration, and the correlations between different levels of modelling are of critical importance to an actual improvement in design know-how. The integration of different methods in the design process is described. Several examples of application illustrate their practical utilization. Comparisons between computational results and test results show their capabilities as well as their present limitations. The prospects linked to new developments currently under way are discussed.

  11. An advanced electric propulsion diagnostic (AEPD) platform for in-situ characterization of electric propulsion thrusters and ion beam sources

    Bundesmann, Carsten; Eichhorn, Christoph; Scholze, Frank; Spemann, Daniel; Neumann, Horst; Pagano, Damiano; Scaranzin, Simone; Scortecci, Fabrizio; Leiter, Hans J.; Gauter, Sven; Wiese, Ruben; Kersten, Holger; Holste, Kristof; Köhler, Peter; Klar, Peter J.; Mazouffre, Stéphane; Blott, Richard; Bulit, Alexandra; Dannenmayer, Käthe


    Experimental characterization is an essential task in development, qualification and optimization process of electric propulsion thrusters or ion beam sources for material processing, because it can verify that the thruster or ion beam source fulfills the requested mission or application requirements, and it can provide parameters for thruster and plasma modeling. Moreover, there is a need for standardizing electric propulsion thruster diagnostics in order to make characterization results of different thrusters and also from measurements performed in different vacuum facilities reliable and comparable. Therefore, we have developed an advanced electric propulsion diagnostic (AEPD) platform, which allows a comprehensive in-situ characterization of electric propulsion thrusters (or ion beam sources) and could serve as a standard on-ground tool in the future. The AEPD platform uses a five-axis positioning system and provides the option to use diagnostic tools for beam characterization (Faraday probe, retarding potential analyzer, ExB probe, active thermal probe), for optical inspection (telemicroscope, triangular laser head), and for thermal characterization (pyrometer, thermocamera). Here we describe the capabilities of the diagnostic platform and provide first experimental results of the characterization of a gridded ion thruster RIT- μX.

  12. Advances in ranking and selection, multiple comparisons, and reliability methodology and applications

    Balakrishnan, N; Nagaraja, HN


    S. Panchapakesan has made significant contributions to ranking and selection and has published in many other areas of statistics, including order statistics, reliability theory, stochastic inequalities, and inference. Written in his honor, the twenty invited articles in this volume reflect recent advances in these areas and form a tribute to Panchapakesan's influence and impact on these areas. Thematically organized, the chapters cover a broad range of topics from: Inference; Ranking and Selection; Multiple Comparisons and Tests; Agreement Assessment; Reliability; and Biostatistics. Featuring

  13. Advancements in electron cyclotron emission imaging demonstrated by the TEXTOR ECEI diagnostic upgrade

    Tobias, B.; Kong, X.; Liang, T.; Spear, A.; Domier, C. W.; Luhmann, N. C. Jr. [University of California at Davis, Davis, California 95616 (United States); Classen, I. G. J.; Boom, J. E.; Pol, M. J. van de; Jaspers, R.; Donne, A. J. H. [Association EURATOM-FOM, FOM Institute for Plasma Physics Rijnhuizen, Trilateral Euregio Cluster, 3430 BE Nieuwegein (Netherlands); Park, H. K. [Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784 (Korea, Republic of); Munsat, T. [University of Colorado at Boulder, Boulder, Colorado 80309 (United States)


    A new TEXTOR electron cyclotron emission imaging system has been developed and employed, providing a diagnostic with new features and enhanced capabilities when compared to the legacy system it replaces. Optical coupling to the plasma has been completely redesigned, making use of new minilens arrays for reduced optical aberration and providing the new feature of vertical zoom, whereby the vertical coverage is now remotely adjustable on a shot-by-shot basis from 20-35 cm. Other innovations, such as the implementation of stacked quasioptical planar notch filters, allow for the diagnostic to be operated without interruption or degradation in performance during electron cyclotron resonance heating. Successful commissioning of the new diagnostic and a demonstration of the improved capabilities are presented in this paper, along with a discussion of the new technologies employed.

  14. Quality assessment of diagnostic before-after studies: development of methodology in the context of a systematic review

    Davenport Clare F


    Full Text Available Abstract Background Quality assessment tools for primary studies of test accuracy are relatively well developed, although only one is validated (QUADAS, but very little work has been done to develop tools to quality-assess studies evaluating the impact of diagnostic testing on management of patients (diagnostic or therapeutic yield. The recent draft NICE Guide to the Methods of Technology Appraisal (2007 suggests QUADAS "as a useful starting point for appraising studies that evaluate the sensitivity and specificity of a test" but does not mention how to quality assess diagnostic or therapeutic yield studies, in particular diagnostic before-after studies. In the context of undertaking a rapid systematic review of structural neuroimaging in psychosis for NICE, we describe the modifications that we made to QUADAS, our experience of this in practice and in relation to published theory on diagnostic or therapeutic yield studies. Methods The QUADAS tool was assessed for use in the review by two systematic reviewers with in-depth knowledge of the clinical area being reviewed and the types of studies being found in the searches that could answer the clinical question. Modifications were made following discussion as considered appropriate. Results Two QUADAS questions were removed altogether and. four additional questions were developed to capture additional quality issues not addressed by QUADAS. However, the developed checklist only partially helped to discern implications of the study designs on the results given. Conclusion The division between topic-specific and more generic quality items of relevance to diagnostic before-after studies is important. With more time, further work could have been done to create a better quality assessment tool, for example by incorporating some of the issues mentioned in previous work in this area. This paper is a discussion around quality assessment and is intended to offer insights into the types of issues that

  15. Recent Advances in Durability and Damage Tolerance Methodology at NASA Langley Research Center

    Ransom, J. B.; Glaessgen, E. H.; Raju, I. S.; Harris, C. E.


    Durability and damage tolerance (D&DT) issues are critical to the development of lighter, safer and more efficient aerospace vehicles. Durability is largely an economic life-cycle design consideration whereas damage tolerance directly addresses the structural airworthiness (safety) of the vehicle. Both D&DT methodologies must address the deleterious effects of changes in material properties and the initiation and growth of damage that may occur during the vehicle s service lifetime. The result of unanticipated D&DT response is often manifested in the form of catastrophic and potentially fatal accidents. As such, durability and damage tolerance requirements must be rigorously addressed for commercial transport aircraft and NASA spacecraft systems. This paper presents an overview of the recent and planned future research in durability and damage tolerance analytical and experimental methods for both metallic and composite aerospace structures at NASA Langley Research Center (LaRC).

  16. Advances in cheminformatics methodologies and infrastructure to support the data mining of large, heterogeneous chemical datasets.

    Guha, Rajarshi; Gilbert, Kevin; Fox, Geoffrey; Pierce, Marlon; Wild, David; Yuan, Huapeng


    In recent years, there has been an explosion in the availability of publicly accessible chemical information, including chemical structures of small molecules, structure-derived properties and associated biological activities in a variety of assays. These data sources present us with a significant opportunity to develop and apply computational tools to extract and understand the underlying structure-activity relationships. Furthermore, by integrating chemical data sources with biological information (protein structure, gene expression and so on), we can attempt to build up a holistic view of the effects of small molecules in biological systems. Equally important is the ability for non-experts to access and utilize state of the art cheminformatics method and models. In this review we present recent developments in cheminformatics methodologies and infrastructure that provide a robust, distributed approach to mining large and complex chemical datasets. In the area of methodology development, we highlight recent work on characterizing structure-activity landscapes, Quantitative Structure Activity Relationship (QSAR) model domain applicability and the use of chemical similarity in text mining. In the area of infrastructure, we discuss a distributed web services framework that allows easy deployment and uniform access to computational (statistics, cheminformatics and computational chemistry) methods, data and models. We also discuss the development of PubChem derived databases and highlight techniques that allow us to scale the infrastructure to extremely large compound collections, by use of distributed processing on Grids. Given that the above work is applicable to arbitrary types of cheminformatics problems, we also present some case studies related to virtual screening for anti-malarials and predictions of anti-cancer activity.

  17. Conventional and Advanced Separations in Mass Spectrometry-Based Metabolomics: Methodologies and Applications

    Heyman, Heino M.; Zhang, Xing; Tang, Keqi; Baker, Erin Shammel; Metz, Thomas O.


    Metabolomics is the quantitative analysis of all metabolites in a given sample. Due to the chemical complexity of the metabolome, optimal separations are required for comprehensive identification and quantification of sample constituents. This chapter provides an overview of both conventional and advanced separations methods in practice for reducing the complexity of metabolite extracts delivered to the mass spectrometer detector, and covers gas chromatography (GC), liquid chromatography (LC), capillary electrophoresis (CE), supercritical fluid chromatography (SFC) and ion mobility spectrometry (IMS) separation techniques coupled with mass spectrometry (MS) as both uni-dimensional and as multi-dimensional approaches.

  18. Advanced Laser-Based Techniques for Gas-Phase Diagnostics in Combustion and Aerospace Engineering.

    Ehn, Andreas; Zhu, Jiajian; Li, Xuesong; Kiefer, Johannes


    Gaining information of species, temperature, and velocity distributions in turbulent combustion and high-speed reactive flows is challenging, particularly for conducting measurements without influencing the experimental object itself. The use of optical and spectroscopic techniques, and in particular laser-based diagnostics, has shown outstanding abilities for performing non-intrusive in situ diagnostics. The development of instrumentation, such as robust lasers with high pulse energy, ultra-short pulse duration, and high repetition rate along with digitized cameras exhibiting high sensitivity, large dynamic range, and frame rates on the order of MHz, has opened up for temporally and spatially resolved volumetric measurements of extreme dynamics and complexities. The aim of this article is to present selected important laser-based techniques for gas-phase diagnostics focusing on their applications in combustion and aerospace engineering. Applicable laser-based techniques for investigations of turbulent flows and combustion such as planar laser-induced fluorescence, Raman and Rayleigh scattering, coherent anti-Stokes Raman scattering, laser-induced grating scattering, particle image velocimetry, laser Doppler anemometry, and tomographic imaging are reviewed and described with some background physics. In addition, demands on instrumentation are further discussed to give insight in the possibilities that are offered by laser flow diagnostics.

  19. Application aspects of advanced antenna diagnostics with the 3D reconstruction algorithm

    Cappellin, Cecilia; Pivnenko, Sergey


    This paper focuses on two important applications of the 3D reconstruction algorithm of the commercial software DIATOOL for antenna diagnostics. The first one is the accurate and detailed identification of array malfunctioning, thanks to the available enhanced spatial resolution of the reconstructed...

  20. Advanced signal processing theory and implementation for sonar, radar, and non-invasive medical diagnostic systems

    Stergiopoulos, Stergios


    Integrates topics of signal processing from sonar, radar, and medical system technologies by identifying their concept similarities. This book covers non-invasive medical diagnostic system applications, including intracranial ultrasound, a technology that attempts to address non-invasive detection on brain injuries and stroke.

  1. Displacement analysis of diagnostic ultrasound backscatter: A methodology for characterizing, modeling, and monitoring high intensity focused ultrasound therapy


    Accurate monitoring of high intensity focused ultrasound (HIFU) therapy is critical for widespread clinical use. Pulse-echo diagnostic ultrasound (DU) is known to exhibit temperature sensitivity through relative changes in time-of-flight between two sets of radio frequency (RF) backscatter measurements, one acquired before and one after therapy. These relative displacements, combined with knowledge of the exposure protocol, material properties, heat transfer, and measurement noise statistics,...

  2. Advances in Methodology in Geriatric Mental Health: Application to Studies of Alzheimer Disease and Related Disorders.

    Bruce, Martha L


    Looking back to 1993, the articles published in the American Journal of Geriatric Psychiatry's inaugural issue focused on central questions in geriatric psychiatry-from how age-related changes in brain structure and function affect illness etiology, expression, course, and outcomes(1) to how best to identify and address the unmet mental health needs in different populations of older adult.(2) Today's journal reflects both an enduring commitment to these questions and the growth of the field itself, both in terms of scientific advancement and the breadth of research that is relevant. Thus, questions with pressing clinical and public health significance continue to be addressed but with increasing sophistication in specificity to the questions and the availability of tools to investigate them. Copyright © 2016 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

  3. Programming methodology and performance issues for advanced computer architectures. [Linear algebra

    Dongarra, J.J.; Sorensen, D.C.; Connolly, K.; Patterson, J.


    This paper will describe some recent attempts to construct transportable numerical software for high performance computers. Restructuring algorithms in terms of simple linear algebra modules is reviewed. This technique has proved very successful in obtaining a high level of transportability without severe loss of performance on a wide variety of both vector and parallel computers. The use of modules to encapsulate parallelism and reduce the ratio of data movement to floating point operations has been demonstrably effective for regular problems such as those found in dense linear algebra. In other situations it may be necessary to express explicitly parallel algorithms. We also present a programming methodology that is useful for constructing new parallel algorithms which require sophisticated synchronization at a large grain level. We describe the SCHEDULE package which provides an environment for developing and analyzing explicitly parallel programs in Fortran which aare portable. This package now includes a preprocessor to achieve complete portability of user level code and also a graphics post processor for performance analysis and debugging. We discuss details of porting both the SCHEDULE package and user code. Examples from linear algebra, and partial differential equations are used to illustrate the utility of this approach.

  4. The advanced eccentricity and broken cage diagnostic method for medium voltage induction motors

    Janda Žarko; Janković Marko; Milošević Mladen; Jovanović Blagota


    In the paper the comparative diagnostics of medium voltage induction motors has been presented. The methods employed are the motor current signature analysis (MCSA) and the axial leakage flux spectral analysis. All presented test procedures have been conducted on partially loaded motors, one without fault and the other with fault. Rated parameters of case study motors are 6 kV and 3.15 MW, and both motors are installed in one combined steam power plant. The reliable broken rotor bars detectio...

  5. Recent advances and results from the solid radiochemistry nuclear diagnostic at the National Ignition Facility

    Gharibyan, N.; Shaughnessy, D. A.; Moody, K. J.; Grant, P. M.; Despotopulos, J. D.; Faye, S. A.; Jedlovec, D. R.; Yeamans, C. B.


    The solid debris collection capability at the National Ignition Facility has been expanded to include a third line-of-sight assembly. The solid radiochemistry nuclear diagnostic measurement of the ratio of gold isotopes is dependent on the efficient collection of neutron-activated hohlraum debris by passive metal disks. The collection of target debris at this new location is more reliable in comparison to the historic locations, and it appears to be independent of collector surface ablation.

  6. Comparison of advanced optical imaging techniques with current otolaryngology diagnostics for improved middle ear assessment (Conference Presentation)

    Nolan, Ryan M.; Shelton, Ryan L.; Monroy, Guillermo L.; Spillman, Darold R.; Novak, Michael A.; Boppart, Stephen A.


    Otolaryngologists utilize a variety of diagnostic techniques to assess middle ear health. Tympanometry, audiometry, and otoacoustic emissions examine the mobility of the tympanic membrane (eardrum) and ossicles using ear canal pressure and auditory tone delivery and detection. Laser Doppler vibrometry provides non-contact vibrational measurement, and acoustic reflectometry is used to assess middle ear effusion using sonar. These technologies and techniques have advanced the field beyond the use of the standard otoscope, a simple tissue magnifier, yet the need for direct visualization of middle ear disease for superior detection, assessment, and management remains. In this study, we evaluated the use of portable optical coherence tomography (OCT) and pneumatic low-coherence interferometry (LCI) systems with handheld probe delivery to standard tympanometry, audiometry, otoacoustic emissions, laser Doppler vibrometry, and acoustic reflectometry. Comparison of these advanced optical imaging techniques and current diagnostics was conducted with a case study subject with a history of unilateral eardrum trauma. OCT and pneumatic LCI provide novel dynamic spatiotemporal structural data of the middle ear, such as the thickness of the eardrum and quantitative detection of underlying disease pathology, which could allow for more accurate diagnosis and more appropriate management than currently possible.

  7. Current companion diagnostics in advanced colorectal cancer; getting a bigger and better piece of the pie.

    Loree, Jonathan M; Kopetz, Scott; Raghav, Kanwal P S


    While the treatment of colorectal cancer continues to rely heavily on conventional cytotoxic therapy, an increasing number of targeted agents are under development. Many of these treatments require companion diagnostic tests in order to define an appropriate population that will derive benefit. In addition, a growing number of biomarkers provide prognostic information about a patient's malignancy. As we learn more about these biomarkers and their assays, selecting the appropriate companion diagnostic becomes increasingly important. In the case of many biomarkers, there are numerous assays which could provide the same information to a treating physician, however each assay has strengths and weaknesses. Institutions must balance cost, assay sensitivity, turn-around time, and labor resources when selecting which assay to offer. In this review we will discuss the current state of companion diagnostics available in metastatic colorectal cancer and explore emerging biomarkers and their assays. We will focus on KRAS, BRAF, HER2, and PIK3CA testing, as well as microsatellite stability assessment and multigene panels.

  8. A methodology for the environmental assessment of advanced coal extraction systems

    Sullivan, P. J.; Hutchinson, C. F.; Makihara, J.; Evensizer, J.


    Procedures developed to identify and assess potential environment impacts of advanced mining technology as it moves from a generic concept to a more systems definition are described. Two levels of assessment are defined in terms of the design stage of the technology being evaluated. The first level of analysis is appropriate to a conceptual design. At this level it is assumed that each mining process has known and potential environmental impacts that are generic to each mining activity. By using this assumption, potential environmental impacts can be identified for new mining systems. When two or more systems have been assessed, they can be evaluated comparing potential environmental impacts. At the preliminary stage of design, a systems performance can be assessed again with more precision. At this level of systems definition, potential environmental impacts can be analyzed and their significane determined in a manner to facilitate comparisons between systems. At each level of analysis, suggestions calculated to help the designer mitigate potentially harmful impacts are provided.

  9. An intersectionality-based policy analysis framework: critical reflections on a methodology for advancing equity.

    Hankivsky, Olena; Grace, Daniel; Hunting, Gemma; Giesbrecht, Melissa; Fridkin, Alycia; Rudrum, Sarah; Ferlatte, Olivier; Clark, Natalie


    In the field of health, numerous frameworks have emerged that advance understandings of the differential impacts of health policies to produce inclusive and socially just health outcomes. In this paper, we present the development of an important contribution to these efforts - an Intersectionality-Based Policy Analysis (IBPA) Framework. Developed over the course of two years in consultation with key stakeholders and drawing on best and promising practices of other equity-informed approaches, this participatory and iterative IBPA Framework provides guidance and direction for researchers, civil society, public health professionals and policy actors seeking to address the challenges of health inequities across diverse populations. Importantly, we present the application of the IBPA Framework in seven priority health-related policy case studies. The analysis of each case study is focused on explaining how IBPA: 1) provides an innovative structure for critical policy analysis; 2) captures the different dimensions of policy contexts including history, politics, everyday lived experiences, diverse knowledges and intersecting social locations; and 3) generates transformative insights, knowledge, policy solutions and actions that cannot be gleaned from other equity-focused policy frameworks. The aim of this paper is to inspire a range of policy actors to recognize the potential of IBPA to foreground the complex contexts of health and social problems, and ultimately to transform how policy analysis is undertaken.

  10. Methodological study and application of advanced receptor modeling to airborne particulate sources

    Chueinta, Wanna

    Two aspects of air quality management, aerosol mass measurement and pollution source identification, were studied. A beta gauge was developed to determine particulate mass collected on filter. Two advanced receptor models were applied to resolve possible sources of pollutants on local and regional scales by use of positive matrix factorization (PMF) and multilinear engine (ME), respectively. A simple, low cost beta gauge was designed, constructed, and tested to determine if it provided the necessary performance and reliability in collected aerosol mass measurements. The beta gauge was calibrated and evaluated by experiments with different sized particles. The results showed that the unit provided a satisfactory accuracy and precision with respect to the gravimetric method. (PMF) is a least-square approach to factor analysis. In this study, PMF was applied to investigate the possible sources of airborne particulate matter (APM) collected at an urban residential area of Bangkok from June 1995 to May 1996 and at a suburban residential area in Pathumthani from September 1993 to August 1994. The data consisting of the fine and coarse fractions were analyzed separately. The analysis used the robust analysis mode and rotations to produce six source factors for both the fine and coarse fractions at the urban site and five factors for the fine and coarse fractions at the suburban site. Examination of the influence of wind direction showed the correspondence of some specific factors such as sea salt and vehicle sources with known area sources. ME is a new algorithm for solving a broad range of multilinear problems. A model was developed for the analysis of spatial patterns and possible sources affecting haze and its visual effects in the southwestern United States. The data from the project Measurement of Haze and Visual Effects (MOHAVE) collected during the late winter and mid-summer of 1992 at the monitoring sites in four states, i.e., California, Arizona, Nevada and Utah

  11. Advances in diagnostic and treatment options in patients with fibromyalgia syndrome

    Ali Gur


    Full Text Available Ali Gur1, Pelin Oktayoglu21Department of Physical Medicine and Rehabilitation, Medical Faculty, Gaziantep University, Gaziantep, Turkey; 2Department of Physical Medicine and Rehabilitation, Batman State Hospital, Batman, TurkeyAbstract: Fibromyalgia (FM is characterized as a chronic, painful, noninflammatory syndrome affecting the musculoskeletal system. In addition to pain, common co-morbid symptoms associated with FM include sleep disturbances, fatigue, morning stiffness, affective disorders, chronic daily headache, dyscognition, irritable bowel syndrome, and irritable bladder. Fibromyalgia is usually classified by application of the American College of Rheumatology (ACR criteria. Although these criteria are accepted among investigators who agree with the concept of fibromyalgia, they do so with some reservations. Tender points and widespread pain alone does not describe the esence of fibromyalgia. New diagnostic tools including either clinical or radiological components are studied to diminish these problems. Although various pharmacological solutions have been studied for treating fibromyalgia, no single drug or groups of drugs have proved to be useful in treating fibromyalgia patients. Recently, three drugs, pregabalin, duloxetine and milnacipran, were approved for the treatment of FM by the US Food and Drug Administration (FDA. Novel therapeutic approaches to the management of FM include cannabinoids, sodium channel blockade and new generation antiepileptics. This review evaluates both new diagnostic tools, including clinical or radiological regimes, and tries to highlight the efficacy of medicinal and nonmedicinal treatments with new therapeutic approaches in the management of FM with a wide perspective.Keywords: diagnosis, fibromyalgia, rehabilitation, treatment

  12. An Epidemiological Survey of Cachexia in Advanced Cancer Patients and Analysis on Its Diagnostic and Treatment Status.

    Sun, Lei; Quan, Xiao-Qing; Yu, Shiying


    Recently, an international consensus diagnostic criterion for cancer cachexia was proposed. The aim of the study is to assess the prevalence of cachexia in patients with advanced cancer and to assess the current status of the diagnosis and management of cancer cachexia. A total of 390 patients with advanced cancer were included. There were 140 patients with cachexia and the prevalence was 35.9%. The prevalence was highest in pancreatic cancer (88.9%), followed by gastric cancer (76.5%) and esophageal cancer (52.9%). Sixty-three patients with cancer cachexia have CT scans available for muscle mass evaluation and 98.4% were sarcopenic. Cachectic patients have a significantly lower overall quality of life and a higher symptom burden. According to oncology physicians, only 33 patients were considered to have cancer cachexia. The false negative rate amounted to 76.4%. The positive rate was related to the body mass index and Eastern Cooperative Oncology Group performance status of the patients. There were few types of pharmacological approaches for cancer cachexia and more than half of cachectic patients did not receive any anticachexia treatment. These results indicate that the prevalence of cachexia in advanced cancer patients was high. However, cancer cachexia was rarely recognized and clinical management for cancer cachexia was very inadequate.

  13. Skin imprinting in silica plates: a potential diagnostic methodology for leprosy using high-resolution mass spectrometry.

    Lima, Estela de Oliveira; de Macedo, Cristiana Santos; Esteves, Cibele Zanardi; de Oliveira, Diogo Noin; Pessolani, Maria Cristina Vidal; Nery, José Augusto da Costa; Sarno, Euzenir Nunes; Catharino, Rodrigo Ramos


    Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which primarily infects macrophages and Schwann cells, affecting skin and peripheral nerves. Clinically, the most common form of identification is through the observation of anesthetic lesions on skin; however, up to 30% of infected patients may not present this clinical manifestation. Currently, the gold standard diagnostic test for leprosy is based on skin lesion biopsy, which is invasive and presents low sensibility for suspect cases. Therefore, the development of a fast, sensible and noninvasive method that identifies infected patients would be helpful for assertive diagnosis. The aim of this work was to identify lipid markers in leprosy patients directly from skin imprints, using a mass spectrometric analytical strategy. For skin imprint samples, a 1 cm(2) silica plate was gently pressed against the skin of patients or healthy volunteers. Imprinted silica lipids were extracted and submitted to direct-infusion electrospray ionization high-resolution mass spectrometry (ESI-HRMS). All samples were differentiated using a lipidomics-based data workup employing multivariate data analysis, which helped electing different lipid markers, for example, mycobacterial mycolic acids, inflammatory and apoptotic molecules were identified as leprosy patients' markers. Otherwise, phospholipids and gangliosides were pointed as healthy volunteers' skin lipid markers, according to normal skin composition. Results indicate that silica plate skin imprinting associated with ESI-HRMS is a promising fast and sensible leprosy diagnostic method. With a prompt leprosy diagnosis, an early and effective treatment could be feasible and thus the chain of leprosy transmission could be abbreviated.

  14. Advanced polymer membrane development in pervaporation dehydration and lateral flow diagnostics

    Flynn, Eoin Joseph


    The work in this thesis concerns the advanced development of polymeric membranes of two types; pervaporation and lateral-flow. The former produced from a solution casting method and the latter from a phase separation. All membranes were produced from casting lacquers. Early research centred on the development of viable membranes. This led to a supported polymer blend pervaporation membrane. Selective layer: plasticized 4:1 mass ratio sodium-alginate: poly(vinyl-alcohol) polymer blend. Using t...

  15. Capillary electrophoretic methods in the development of metal-based therapeutics and diagnostics: new methodology and applications.

    Bytzek, Anna K; Hartinger, Christian G


    In recent years, capillary electrophoresis (CE) has matured to a standard method in medicinal inorganic chemistry. More and more steps of the drug discovery process are followed by CE. However, not only the number of applications has steadily increased but also the variety of used methodology has significantly broadened and, as compared to a few years ago, a wider scope of separation modes and hyphenated systems has been used. Herein, a summary of the newly utilized CE methods and their applications in metallodrug research in the timeframe 2006-2011 is presented, following related reviews from 2003 and 2007 (Electrophoresis, 2003, 24, 2023-2037; Electrophoresis 2007, 28, 3436-3446). Areas covered include impurity profiling, quality control of pharmaceutical formulations, lipophilicity estimation, interactions between metallodrugs and proteins or nucleotides, and characterization and also quantification of metabolites in biological matrices and real-world samples.

  16. Advanced microscopic and histochemical techniques: diagnostic tools in the molecular era of myology

    G Meola


    Full Text Available Over the past two centuries, myology (i.e. the basic and clinical science of muscle and muscle disease has passed through 3 stages of development: the classical period, the modern stage and the molecular era. The classical period spans the last part of nineteenth century and the earlier part of the twentieth century. During this time, several major muscle disease were clinically and pathologically characterized, including Duchenne muscular dystrophy (DMD, myotonic dystrophy (DM and facioscapulohumeral dystrophy (FSHD. The modern stage in the second half of the twentieth century is characterized by the adaptation of histo and cytochemical techniques to the study of muscle biopsies. These tools improved the diagnostic accuracy and made possible the identification of new changes and structures (Engel and Cunningham, 1963; Scarlato, 1975.

  17. The advanced eccentricity and broken cage diagnostic method for medium voltage induction motors

    Janda Žarko


    Full Text Available In the paper the comparative diagnostics of medium voltage induction motors has been presented. The methods employed are the motor current signature analysis (MCSA and the axial leakage flux spectral analysis. All presented test procedures have been conducted on partially loaded motors, one without fault and the other with fault. Rated parameters of case study motors are 6 kV and 3.15 MW, and both motors are installed in one combined steam power plant. The reliable broken rotor bars detection and existence of static eccentricity have been demonstrated. The new method for combined fault detection has also been announced. The combined fault under scope is the simultaneous existence of broken rotor bars and static eccentricity. The proposed combined fault detection method is based upon axial leakage flux spectral analysis, especially in the vicinity of the double fundamental frequency. The existence of three broken rotor bars has been confirmed after physical rotor cage examination.

  18. Current Advances on Virus Discovery and Diagnostic Role of Viral Metagenomics in Aquatic Organisms

    Munang'andu, Hetron M.; Mugimba, Kizito K.; Byarugaba, Denis K.; Mutoloki, Stephen; Evensen, Øystein


    The global expansion of the aquaculture industry has brought with it a corresponding increase of novel viruses infecting different aquatic organisms. These emerging viral pathogens have proved to be a challenge to the use of traditional cell-cultures and immunoassays for identification of new viruses especially in situations where the novel viruses are unculturable and no antibodies exist for their identification. Viral metagenomics has the potential to identify novel viruses without prior knowledge of their genomic sequence data and may provide a solution for the study of unculturable viruses. This review provides a synopsis on the contribution of viral metagenomics to the discovery of viruses infecting different aquatic organisms as well as its potential role in viral diagnostics. High throughput Next Generation sequencing (NGS) and library construction used in metagenomic projects have simplified the task of generating complete viral genomes unlike the challenge faced in traditional methods that use multiple primers targeted at different segments and VPs to generate the entire genome of a novel virus. In terms of diagnostics, studies carried out this far show that viral metagenomics has the potential to serve as a multifaceted tool able to study and identify etiological agents of single infections, co-infections, tissue tropism, profiling viral infections of different aquatic organisms, epidemiological monitoring of disease prevalence, evolutionary phylogenetic analyses, and the study of genomic diversity in quasispecies viruses. With sequencing technologies and bioinformatics analytical tools becoming cheaper and easier, we anticipate that metagenomics will soon become a routine tool for the discovery, study, and identification of novel pathogens including viruses to enable timely disease control for emerging diseases in aquaculture.

  19. Proceedings of the advanced research and technology development direct utilization, instrumentation and diagnostics contractors' review meeting

    Geiling, D.W. (USDOE Morgantown Energy Technology Center, WV (USA)); Goldberg, P.M. (eds.) (USDOE Pittsburgh Energy Technology Center, PA (USA))


    The 1990 Advanced Research and Technology Development (AR TD) Direct Utilization, and Instrumentation and Diagnostics Contractors Review Meeting was held September 16--18, 1990, at the Hyatt at Chatham Center in Pittsburgh, PA. The meeting was sponsored by the US Department of Energy (DOE), Office of Fossil Energy, and the Pittsburgh and Morgantown Energy Technology Centers. Each year the meeting provides a forum for the exchange of information among the DOE AR TD contractors and interested parties. This year's meeting was hosted by the Pittsburgh Energy Technology Center and was attended by 120 individuals from industry, academia, national laboratories, and other governmental agencies. Papers were presented on research addressing coal surface, science, devolatilization and combustion, ash behavior, emission controls for gases particulates, fluid bed combustion and utilization in diesels and turbines. Individual reports are processed separately for the data bases.

  20. High sensitivity far infrared laser diagnostics for the C-2U advanced beam-driven field-reversed configuration plasmas

    Deng, B. H., E-mail:; Beall, M.; Schroeder, J.; Settles, G.; Feng, P.; Kinley, J. S.; Gota, H.; Thompson, M. C. [Tri Alpha Energy, Inc., P.O. Box 7010, Rancho Santa Margarita, California 92688 (United States)


    A high sensitivity multi-channel far infrared laser diagnostics with switchable interferometry and polarimetry operation modes for the advanced neutral beam-driven C-2U field-reversed configuration (FRC) plasmas is described. The interferometer achieved superior resolution of 1 × 10{sup 16} m{sup −2} at >1.5 MHz bandwidth, illustrated by measurement of small amplitude high frequency fluctuations. The polarimetry achieved 0.04° instrument resolution and 0.1° actual resolution in the challenging high density gradient environment with >0.5 MHz bandwidth, making it suitable for weak internal magnetic field measurements in the C-2U plasmas, where the maximum Faraday rotation angle is less than 1°. The polarimetry resolution data is analyzed, and high resolution Faraday rotation data in C-2U is presented together with direct evidences of field reversal in FRC magnetic structure obtained for the first time by a non-perturbative method.

  1. High sensitivity far infrared laser diagnostics for the C-2U advanced beam-driven field-reversed configuration plasmas

    Deng, B. H.; Beall, M.; Schroeder, J.; Settles, G.; Feng, P.; Kinley, J. S.; Gota, H.; Thompson, M. C.


    A high sensitivity multi-channel far infrared laser diagnostics with switchable interferometry and polarimetry operation modes for the advanced neutral beam-driven C-2U field-reversed configuration (FRC) plasmas is described. The interferometer achieved superior resolution of 1 × 1016 m-2 at >1.5 MHz bandwidth, illustrated by measurement of small amplitude high frequency fluctuations. The polarimetry achieved 0.04° instrument resolution and 0.1° actual resolution in the challenging high density gradient environment with >0.5 MHz bandwidth, making it suitable for weak internal magnetic field measurements in the C-2U plasmas, where the maximum Faraday rotation angle is less than 1°. The polarimetry resolution data is analyzed, and high resolution Faraday rotation data in C-2U is presented together with direct evidences of field reversal in FRC magnetic structure obtained for the first time by a non-perturbative method.

  2. T-R Cycle Characterization and Imaging: Advanced Diagnostic Methodology for Petroleum Reservoir and Trap Detection and Delineation

    Ernest A. Mancini; William C. Parcell; Bruce S. Hart


    The principal research effort for Year 2 of the project is on stratigraphic model assessment and development. The research focus for the first six (6) months of Year 2 is on T-R cycle model development. The emphasis for the remainder of the year is on assessing the depositional model and developing and testing a sequence stratigraphy model. The development and testing of the sequence stratigraphy model has been accomplished through integrated outcrop, well log and seismic studies of Mesozoic strata in the Gulf of Mexico, North Atlantic and Rocky Mountain areas.

  3. T-R Cycle Characterization and Imaging: Advanced Diagnostic Methodology for Petroleum Reservoir and Trap Detection and Delineation

    Ernest A. Mancini


    Characterization of stratigraphic sequences (T-R cycles or sequences) included outcrop studies, well log analysis and seismic reflection interpretation. These studies were performed by researchers at the University of Alabama, Wichita State University and McGill University. The outcrop, well log and seismic characterization studies were used to develop a depositional sequence model, a T-R cycle (sequence) model, and a sequence stratigraphy predictive model. The sequence stratigraphy predictive model developed in this study is based primarily on the modified T-R cycle (sequence) model. The T-R cycle (sequence) model using transgressive and regressive systems tracts and aggrading, backstepping, and infilling intervals or sections was found to be the most appropriate sequence stratigraphy model for the strata in the onshore interior salt basins of the Gulf of Mexico to improve petroleum stratigraphic trap and specific reservoir facies imaging, detection and delineation. The known petroleum reservoirs of the Mississippi Interior and North Louisiana Salt Basins were classified using T-R cycle (sequence) terminology. The transgressive backstepping reservoirs have been the most productive of oil, and the transgressive backstepping and regressive infilling reservoirs have been the most productive of gas. Exploration strategies were formulated using the sequence stratigraphy predictive model and the classification of the known petroleum reservoirs utilizing T-R cycle (sequence) terminology. The well log signatures and seismic reflector patterns were determined to be distinctive for the aggrading, backstepping and infilling sections of the T-R cycle (sequence) and as such, well log and seismic data are useful for recognizing and defining potential reservoir facies. The use of the sequence stratigraphy predictive model, in combination with the knowledge of how the distinctive characteristics of the T-R system tracts and their subdivisions are expressed in well log patterns and seismic reflection configurations and terminations, improves the ability to identify and define the limits of potential stratigraphic traps and the stratigraphic component of combination stratigraphic and structural traps and the associated continental, coastal plain and marine potential reservoir facies. The assessment of the underdeveloped and undiscovered reservoirs and resources in the Mississippi Interior and North Louisiana Salt Basins resulted in the confirmation of the Monroe Uplift as a feature characterized by a major regional unconformity, which serves as a combination stratigraphic and structural trap with a significant stratigraphic component, and the characterization of a developing play in southwest Alabama, which involves a stratigraphic trap, located updip near the pinchout of the potential reservoir facies. Potential undiscovered and underdeveloped reservoirs in the onshore interior salt basins are identified as Jurassic and Cretaceous aggrading continental and coastal, backstepping nearshore marine and marine shelf, and infilling fluvial, deltaic, coastal plain and marine shelf.


    Ernest A. Mancini


    The principal research effort for Year 1 of the project has been T-R cycle characterization and modeling. The research focus for the first nine (9) months of Year 1 was on outcrop study, well log analysis, seismic interpretation and data integration and for the remainder of the year the emphasis has been on T-R cycle model development. Information regarding the characteristics of T-R cycles has been assembled from the study of outcrops, from well log analyses, and from seismic reflection interpretation. From these studies, stratal boundaries separating T-R cycles have been found to be useful for the recognition and delineation of these cycles. The key stratal surfaces include subaerial unconformities, shoreface ravinement surfaces, transgressive surfaces, surfaces of maximum regression, and surfaces of maximum transgression. These surfaces can be identified and mapped in surface exposures and can be recognized in well log signatures and seismic reflection profiles as discontinuities. The findings from the study of outcrop, well log, and seismic reflection data are being integrated into a database for use in constructing a model for T-R cycle development.

  5. Displacement analysis of diagnostic ultrasound backscatter: a methodology for characterizing, modeling, and monitoring high intensity focused ultrasound therapy.

    Speyer, Gavriel; Kaczkowski, Peter J; Brayman, Andrew A; Crum, Lawrence A


    Accurate monitoring of high intensity focused ultrasound (HIFU) therapy is critical for widespread clinical use. Pulse-echo diagnostic ultrasound (DU) is known to exhibit temperature sensitivity through relative changes in time-of-flight between two sets of radio frequency (RF) backscatter measurements, one acquired before and one after therapy. These relative displacements, combined with knowledge of the exposure protocol, material properties, heat transfer, and measurement noise statistics, provide a natural framework for estimating the administered heating, and thereby therapy. The proposed method, termed displacement analysis, identifies the relative displacements using linearly independent displacement patterns, or modes, each induced by a particular time-varying heating applied during the exposure interval. These heating modes are themselves linearly independent. This relationship implies that a linear combination of displacement modes aligning the DU measurements is the response to an identical linear combination of heating modes, providing the heating estimate. Furthermore, the accuracy of coefficient estimates in this approximation is determined a priori, characterizing heating, thermal dose, and temperature estimates for any given protocol. Predicted performance is validated using simulations and experiments in alginate gel phantoms. Evidence for a spatially distributed interaction between temperature and time-of-flight changes is presented.

  6. Differences in Regional Diagnostic Strategies and in Intended Versus Actual First-Line Treatment of Patients With Advanced Ovarian Cancer in Denmark

    Fagö-Olsen, Carsten Lindberg; Ottesen, Bent; Kehlet, Henrik


    BACKGROUND: Triage of patients with ovarian cancer to primary debulking surgery (PDS) or neoadjuvant chemotherapy (NACT) is challenging. In Denmark, the use of NACT has increased, but substantial differences in the use of NACT or PDS exist among centers. We aimed to characterize the differences b......-line treatments as well as in the diagnostic process and use of NACT, calling for further discussion on diagnostic strategy and therapeutically approach for patients with advanced ovarian cancer....

  7. Potential of advanced photoplethysmography sensing for noninvasive vascular diagnostics and early screening

    Spigulis, Janis; Kukulis, Indulis; Fridenberga, Eva; Venckus, Girts


    Advanced sensor device for shape analysis of the tissue- reflected mean single period photoplethysmography (SPPPG) signals has been designed and clinically tested. The SPPPG signal shape reveals individual features of the patient's cardio-vascular state. Clinical studies of several patient groups (e.g. diabetes mellitus, atherosclerosis obliterans, Raynaud's syndrome) made possible to specify components of the SPPPG signal that are sensitive to the corresponding organic or functional pathologies. Comparison of the right and left arm finger SPPPG signal shapes, for instance, appears to be efficient tool for early screening of unilateral atherosclerosis obliterans.

  8. Advances in circulating microRNAs as diagnostic and prognostic markers for ovarian cancer

    Hong Zheng; Jia-Yu Liu; Feng-Ju Song; Ke-Xin Chen


    Ovarian cancer is one of the most lethal malignant gynecological tumors. More than 70%of patients with ovarian cancer are diagnosed at advanced stage. The 5-year survival in patients with advanced ovarian cancer is less than 30%because of the lack of effective biomarkers for diagnosis, prognosis, and personalized treatment. MicroRNA (miR) is a class of small noncoding RNAs that negatively regulate gene expression primarily through post-transcriptional repression. Many studies on tissue miR in ovarian cancer have been carried out and show great potential in clinical practice. However, tissue samples are not easily available because sampling causes injury. Researchers have started to focus on plasma/serum miR, assuming that blood samples may replace tissue samples in miR research in the future. Plasma/serum miR research is still in its early stages. Studies on its function in the early diagnosis of ovarian cancer have achieved some progress, but plasma/serum miR profiling for prognosis and personalized treatment of ovarian cancer remains unknown. A thorough understanding of the function of plasma/serum miR in ovarian cancer will facilitate early diagnosis and improve treatment for ovarian cancer.

  9. Serum Advanced Oxidation Protein Products in Oral Squamous Cell Carcinoma: Possible Markers of Diagnostic Significance

    Abhishek Singh Nayyar


    Full Text Available Background: The aim of this study was to measure the concentrations (levels ofserum total proteins and advanced oxidation protein products as markers of oxidantmediated protein damage in the sera of patients with oral cancers.Methods: The study consisted of the sera analyses of serum total protein andadvanced oxidation protein products’ levels in 30 age and sex matched controls, 60patients with reported pre-cancerous lesions and/or conditions and 60 patients withhistologically proven oral squamous cell carcinoma. One way analyses of variance wereused to test the difference between groups. To determine which of the two groups’ meanswere significantly different, the post-hoc test of Bonferroni was used. The results wereaveraged as mean ± standard deviation. In the above test, P values less than 0.05 weretaken to be statistically significant. The normality of data was checked before thestatistical analysis was performed.Results: The study revealed statistically significant variations in serum levels ofadvanced oxidation protein products (P<0.001. Serum levels of total protein showedextensive variations; therefore the results were largely inconclusive and statisticallyinsignificant.Conclusion: The results emphasize the need for more studies with larger samplesizes to be conducted before a conclusive role can be determined for sera levels of totalprotein and advanced oxidation protein products as markers both for diagnosticsignificance and the transition from the various oral pre-cancerous lesions and conditionsinto frank oral cancers.

  10. [Tick-borne rickettsioses in the Americas: clinical and epidemiological advances, and diagnostic challenges].

    Hidalgo, Marylin; Faccini-Martínez, Álvaro A; Valbuena, Gustavo


    Rickettsioses are a group of zoonotic diseases caused by strict intracellular bacteria of the genus Rickettsia and Orientia which belong to the Rickettsiaceae family. Their ecology is influenced by environmental factors and the presence of specific vectors that determine the establishment and epidemiology in different world regions. In America, during the 20 th century, only three of these diseases were recognized: Rocky Mountain spotted fever, epidemic typhus and endemic typhus. However, since 2000, more than 10 different species that had previously been unknown in this continent have been described, both in arthropods and in clinical cases, fact that classifies them as emerging and re-emerging diseases. Given the clinical manifestations of the diseases caused by rickettsias, being the majority unspecific and, therefore, shared with other infectious diseases, especially viral and bacterial, they have been framed within the differential diagnoses of acute febrile syndrome in urban and tropical areas. Nowadays, there are direct and indirect diagnostic methods, which are useful in the definition of the infectious agent, in this case, the cause of rickettsioses.

  11. Recent Advances on Pathophysiology, Diagnostic and Therapeutic Insights in Cardiac Dysfunction Induced by Antineoplastic Drugs

    Marilisa Molinaro


    Full Text Available Along with the improvement of survival after cancer, cardiotoxicity due to antineoplastic treatments has emerged as a clinically relevant problem. Potential cardiovascular toxicities due to anticancer agents include QT prolongation and arrhythmias, myocardial ischemia and infarction, hypertension and/or thromboembolism, left ventricular (LV dysfunction, and heart failure (HF. The latter is variable in severity, may be reversible or irreversible, and can occur soon after or as a delayed consequence of anticancer treatments. In the last decade recent advances have emerged in clinical and pathophysiological aspects of LV dysfunction induced by the most widely used anticancer drugs. In particular, early, sensitive markers of cardiac dysfunction that can predict this form of cardiomyopathy before ejection fraction (EF is reduced are becoming increasingly important, along with novel therapeutic and cardioprotective strategies, in the attempt of protecting cardiooncologic patients from the development of congestive heart failure.

  12. Recent Advances on Pathophysiology, Diagnostic and Therapeutic Insights in Cardiac Dysfunction Induced by Antineoplastic Drugs

    Molinaro, Marilisa; Marone, Giancarlo; Abete, Pasquale; Di Lisa, Fabio; De Placido, Sabino; Bonaduce, Domenico; Tocchetti, Carlo G.


    Along with the improvement of survival after cancer, cardiotoxicity due to antineoplastic treatments has emerged as a clinically relevant problem. Potential cardiovascular toxicities due to anticancer agents include QT prolongation and arrhythmias, myocardial ischemia and infarction, hypertension and/or thromboembolism, left ventricular (LV) dysfunction, and heart failure (HF). The latter is variable in severity, may be reversible or irreversible, and can occur soon after or as a delayed consequence of anticancer treatments. In the last decade recent advances have emerged in clinical and pathophysiological aspects of LV dysfunction induced by the most widely used anticancer drugs. In particular, early, sensitive markers of cardiac dysfunction that can predict this form of cardiomyopathy before ejection fraction (EF) is reduced are becoming increasingly important, along with novel therapeutic and cardioprotective strategies, in the attempt of protecting cardiooncologic patients from the development of congestive heart failure. PMID:26583088


    M.H. Al-Dahhan; L.S. Fan; M.P. Dudukovic


    This report summarizes the accomplishment made during the third year of this cooperative research effort between Washington University, Ohio State University and Air Products and Chemicals. Data processing of the performed Computer Automated Radioactive Particle Tracking (CARPT) experiments in 6 inch column using air-water-glass beads (150 {micro}m) system has been completed. Experimental investigation of time averaged three phases distribution in air-Therminol LT-glass beads (150 {micro}m) system in 6 inch column has been executed. Data processing and analysis of all the performed Computed Tomography (CT) experiments have been completed, using the newly proposed CT/Overall gas holdup methodology. The hydrodynamics of air-Norpar 15-glass beads (150 {micro}m) have been investigated in 2 inch slurry bubble column using Dynamic Gas Disengagement (DGD), Pressure Drop fluctuations, and Fiber Optic Probe. To improve the design and scale-up of bubble column reactors, a correlation for overall gas holdup has been proposed based on Artificial Neural Network and Dimensional Analysis.

  14. Advanced beam dynamics and diagnostics concepts for laser-plasma accelerators

    Dornmair, Irene


    Laser-Plasma Accelerators (LPAs) combine a multitude of unique features, which makes them very attractive as drivers for next generation brilliant light sources including compact X-ray free-electron lasers. They provide high accelerating gradients, thereby drastically shrinking the accelerator size, while at the same time the produced electron bunches are intrinsically as short as a few femtoseconds and carry high peak currents. LPA are subject of very active research, yet, the field currently faces the challenge of improving the beam quality, and achieving stable and well-controlled injection and acceleration. This thesis tackles this issue from three different sides. A novellongitudinal phase space diagnostics is proposed that employs the strong fields present in plasma wakefields to streak ultrashort electron bunches. This allows for a temporal resolution down to the attosecond range, enabling direct determination to the current profile and the slice energy spread, both crucial quantities for the performance of free-electron lasers. Furthermore, adiabatic matching sections at the plasma-vacuum boundary are investigated. These can drastically reduce the beam divergence and thereby relax the constraints on the subsequent beam optics. For externally injected beams, the matching sections could even provide the key technology that permits emittance conservation by increasing the matched beam size to a level achievable with currently available magnetic optics. Finally, a new method is studied that allows to modify the wakefield shape. To this end, the plasma density is periodically modulated. One possible application can be to remove the linearly correlated energy spread, or chirp, from the accelerated bunch, which is suspected of being responsible for the main part of the often large energy spread of plasma accelerated beams.

  15. Technological advances in diagnostic testing for von Willebrand disease: new approaches and challenges.

    Hayward, C P M; Moffat, K A; Graf, L


    Diagnostic tests for von Willebrand disease (VWD) are important for the assessment of VWD, which is a commonly encountered bleeding disorder worldwide. Technical innovations have been applied to improve the precision and lower limit of detection of von Willebrand factor (VWF) assays, including the ristocetin cofactor activity assay (VWF:RCo) that uses the antibiotic ristocetin to induce plasma VWF binding to glycoprotein (GP) IbIXV on target platelets. VWF-collagen-binding assays, depending on the type of collagen used, can improve the detection of forms of VWD with high molecular weight VWF multimer loss, although the best method is debatable. A number of innovations have been applied to VWF:RCo (which is commonly performed on an aggregometer), including replacing the target platelets with immobilized GPIbα, and quantification by an enzyme-linked immunosorbent assay (ELISA), immunoturbidimetric, or chemiluminescent end-point. Some common polymorphisms in the VWF gene that do not cause bleeding are associated with falsely low VWF activity by ristocetin-dependent methods. To overcome the need for ristocetin, some new VWF activity assays use gain-of-function GPIbα mutants that bind VWF without the need for ristocetin, with an improved precision and lower limit of detection than measuring VWF:RCo by aggregometry. ELISA of VWF binding to mutated GPIbα shows promise as a method to identify gain-of-function defects from type 2B VWD. The performance characteristics of many new VWF activity assays suggest that the detection of VWD, and monitoring of VWD therapy, by clinical laboratories could be improved through adopting newer generation VWF assays.

  16. Enhanced ultrasound for advanced diagnostics, ultrasound tomography for volume limb imaging and prosthetic fitting

    Anthony, Brian W.


    Ultrasound imaging methods hold the potential to deliver low-cost, high-resolution, operator-independent and nonionizing imaging systems - such systems couple appropriate algorithms with imaging devices and techniques. The increasing demands on general practitioners motivate us to develop more usable and productive diagnostic imaging equipment. Ultrasound, specifically freehand ultrasound, is a low cost and safe medical imaging technique. It doesn't expose a patient to ionizing radiation. Its safety and versatility make it very well suited for the increasing demands on general practitioners, or for providing improved medical care in rural regions or the developing world. However it typically suffers from sonographer variability; we will discuss techniques to address user variability. We also discuss our work to combine cylindrical scanning systems with state of the art inversion algorithms to deliver ultrasound systems for imaging and quantifying limbs in 3-D in vivo. Such systems have the potential to track the progression of limb health at a low cost and without radiation exposure, as well as, improve prosthetic socket fitting. Current methods of prosthetic socket fabrication remain subjective and ineffective at creating an interface to the human body that is both comfortable and functional. Though there has been recent success using methods like magnetic resonance imaging and biomechanical modeling, a low-cost, streamlined, and quantitative process for prosthetic cup design and fabrication has not been fully demonstrated. Medical ultrasonography may inform the design process of prosthetic sockets in a more objective manner. This keynote talk presents the results of progress in this area.

  17. Diagnostic dilemma; report of a bizarre case of advanced scalp and face angiosarcoma and literature review

    Emejulu JKC


    Full Text Available Jude-Kennedy C Emejulu1, Igwebuike V Onyiaorah2, Cornelius O Ukah2, Titus OG Chukwuanukwu3, Nneka JF Osuigwe1, Effiong E Akang4, Adefolarin O Malomo51Neurosurgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria; 2Department of Pathology, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria; 3Plastic Surgery Unit, Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, PMB 5025 Nnewi, Anambra State, Nigeria; 4Department of Pathology, University College Hospital, Ibadan, Oyo State, Nigeria; 5Department of Neurological Surgery, Institute of Neurological Sciences, University College Hospital, Ibadan, Oyo State, NigeriaAbstract: A 36-year-old male painter presented to our service in 2007 with an ulcerated solitary scalp swelling of 8 months’ duration. The mass was a dormant, painless, pea-sized growth, which he had had since childhood and which he bruised in a passenger motorcycle road traffic accident 8 months prior to presentation. The accident caused it to flare up and progressively increase in size, with associated pain, contact bleeding, and ulceration. A work-up for excision biopsy was proposed, but the patient defaulted and presented 2 years later with an increased number of lesions all around the scalp and face and in an obviously deteriorating clinical status with regional lymph node involvement at this stage. An incisional biopsy was then carried out and the histological reports came out with three different diagnoses of glioblastoma multiforme, poorly differentiated angiosarcoma, and squamous cell carcinoma, constituting a major diagnostic dilemma for our service.Keywords: angiosarcoma, glioblastoma multiforme, head, neck, squamous cell carcinoma

  18. Advanced and extended scope practice of diagnostic radiographers in Scotland: Exploring strategic imaging service imperatives.

    Henderson, I; Mathers, S A; McConnell, J


    The development of diagnostic imaging services manifests features specific to the Scottish environment, in particular development of the radiographic workforce through implementing skills mix and role developments to enhance outcomes for patients. A component of a College of Radiographers Industry Partnership Scheme (CoRIPS) supported study, this research investigates perspectives of strategic service managers with Health Board responsibility for service delivery. A questionnaire survey was administered to strategic service managers across Scotland (N = 14), followed up with telephone interviews. There was a return rate of 57% (n = 8) for the questionnaires and n = 4 agreed to be interviewed. Data collected related to radiographer roles across their Board area; awareness and understanding of service development issues and features as well as perspective on opportunities and barriers in the context of Scottish Government policy, workforce logistics, attitudes and inter-professional relationships. The results indicate evidence of financial, logistical and political barriers to service evolution, offset by a sense of optimism that scope for beneficial change may be approaching. There are a range of significant initiatives in place and an appetite exists to pursue the development of radiographer roles and skill mix for the benefit of service users more generally. The difficulties in achieving change are well understood and there are basic issues related to finance and industrial relations. There are also however, cultural elements to contend with in the form of attitudes demonstrated by some radiographers and significantly, the radiological community whose influence on the practice of independently regulated radiographers seems incongruent. Copyright © 2017 The College of Radiographers. Published by Elsevier Ltd. All rights reserved.

  19. Studies of the physical aspects of intumescence using advance diagnostics methods

    Saeed, Hussain; Huang, Hua Wei; Zhang, Yang


    The use of intumescent paints as an active fire protection method has gained immense interest in recent years. A significant aspect of research has focused on studying the chemical aspects of the system to improve performance. The dynamics and physical aspects of intumescence in real time fire conditions are still unclear. The present research uses an experimental approach where diagnostics techniques such as thermal imaging camera was used to study intumescent characteristics that have been not been reported in great detail. T-panels are a substitute to the most commonly used part in construction, the I-beam. Studies were conducted using a cone calorimeter that provided a uniform heat flux through radiation on steel T-panel samples. The complex nature of char movement was recorded and a novel algorithm was used to track the growing char laye07r. The samples are designed to cater to different fire conditions. Therefore, the degree of intumescence was observed to be very different in the samples. The samples designed for low temperature cellulosic fires focus on high degree of intumesce. Whereas, mechanical strength is the focus for samples used in high temperature turbulent hydrocarbon fire conditions. The variation in the internal structure of the sample is presented. Furthermore, the phenomenon is phase shift is discussed. The phase shift is an essential part of the process of intumescence when the majority of intumescence occurs. It was observed to be different in all the samples. The movement of the samples is a property of great interest. This is because if any part of the substrate is exposed then the formulation does not meet strict commercialisation criterion. The movement was diagonal in nature as compared to flat panels where it is perpendicular. This is due tot the heating pattern of the plate that results in the web part of the panel to influence the growth of char on the flange part of the panel. A special case of char cracking is also highlighted and

  20. Smartphone-Based Endoscope System for Advanced Point-of-Care Diagnostics: Feasibility Study

    Bae, Jung Kweon; Vavilin, Andrey; You, Joon S; Kim, Hyeongeun; Ryu, Seon Young; Jang, Jeong Hun


    Background Endoscopic technique is often applied for the diagnosis of diseases affecting internal organs and image-guidance of surgical procedures. Although the endoscope has become an indispensable tool in the clinic, its utility has been limited to medical offices or operating rooms because of the large size of its ancillary devices. In addition, the basic design and imaging capability of the system have remained relatively unchanged for decades. Objective The objective of this study was to develop a smartphone-based endoscope system capable of advanced endoscopic functionalities in a compact size and at an affordable cost and to demonstrate its feasibility of point-of-care through human subject imaging. Methods We developed and designed to set up a smartphone-based endoscope system, incorporating a portable light source, relay-lens, custom adapter, and homebuilt Android app. We attached three different types of existing rigid or flexible endoscopic probes to our system and captured the endoscopic images using the homebuilt app. Both smartphone-based endoscope system and commercialized clinical endoscope system were utilized to compare the imaging quality and performance. Connecting the head-mounted display (HMD) wirelessly, the smartphone-based endoscope system could superimpose an endoscopic image to real-world view. Results A total of 15 volunteers who were accepted into our study were captured using our smartphone-based endoscope system, as well as the commercialized clinical endoscope system. It was found that the imaging performance of our device had acceptable quality compared with that of the conventional endoscope system in the clinical setting. In addition, images captured from the HMD used in the smartphone-based endoscope system improved eye-hand coordination between the manipulating site and the smartphone screen, which in turn reduced spatial disorientation. Conclusions The performance of our endoscope system was evaluated against a commercial

  1. Smartphone-Based Endoscope System for Advanced Point-of-Care Diagnostics: Feasibility Study.

    Bae, Jung Kweon; Vavilin, Andrey; You, Joon S; Kim, Hyeongeun; Ryu, Seon Young; Jang, Jeong Hun; Jung, Woonggyu


    Endoscopic technique is often applied for the diagnosis of diseases affecting internal organs and image-guidance of surgical procedures. Although the endoscope has become an indispensable tool in the clinic, its utility has been limited to medical offices or operating rooms because of the large size of its ancillary devices. In addition, the basic design and imaging capability of the system have remained relatively unchanged for decades. The objective of this study was to develop a smartphone-based endoscope system capable of advanced endoscopic functionalities in a compact size and at an affordable cost and to demonstrate its feasibility of point-of-care through human subject imaging. We developed and designed to set up a smartphone-based endoscope system, incorporating a portable light source, relay-lens, custom adapter, and homebuilt Android app. We attached three different types of existing rigid or flexible endoscopic probes to our system and captured the endoscopic images using the homebuilt app. Both smartphone-based endoscope system and commercialized clinical endoscope system were utilized to compare the imaging quality and performance. Connecting the head-mounted display (HMD) wirelessly, the smartphone-based endoscope system could superimpose an endoscopic image to real-world view. A total of 15 volunteers who were accepted into our study were captured using our smartphone-based endoscope system, as well as the commercialized clinical endoscope system. It was found that the imaging performance of our device had acceptable quality compared with that of the conventional endoscope system in the clinical setting. In addition, images captured from the HMD used in the smartphone-based endoscope system improved eye-hand coordination between the manipulating site and the smartphone screen, which in turn reduced spatial disorientation. The performance of our endoscope system was evaluated against a commercial system in routine otolaryngology examinations. We also

  2. Searching for the elusive typhoid diagnostic

    Baker Stephen


    Full Text Available Abstract Typhoid (enteric fever is still a common disease in many developing countries but current diagnostic tests are inadequate. Studies on pathogenesis and genomics have provided new insight into the organisms that cause enteric fever. Better understanding of the microorganisms explains, in part, why our current typhoid methodologies are limited in their diagnostic information and why developing new strategies may be a considerable challenge. Here we discuss the current position of typhoid diagnostics, highlight the need for technological improvements and suggest potential ways of advancing this area.

  3. the Diagnostic Value of Brain Magnetic Resonance imaging in Detecting CNS Diseases Among Advanced AiDS Patients


    Objective To investigate the diagnostic value of brain magnetic resonance imaging in detecting central nervous system diseases among AIDS patients of different levels of T cells. Methods Total of 164 AIDS patients who did not receive antiviral treatment were divided into 2 groups according to their baseline CD4+T cell counts. Group A had CD4+T cell below or equal to 50 cells/μl (n=81) and group B had CD4+T cells over 50 cells/μl (n=83). All patients underwent brain MRI scan. Imaging analysis and the prevalence of the central nervous system disorders were compared between two groups. Results Among them 48 cases were found of abnormal brain MRI, group A was higher than group B (35.8%vs. 22.9%) although without statistical significance (P = 0.065). Altogether 48 cases were diagnosed as AIDS related central nervous system disorders based on clinical symptoms, signs and laboratory findings. The prevalence of CNS disorders was higher in group A than in group B (41.9%vs. 16.8%) with statistical significance (P<0.01). Conclusions The patients with CD4+T cell count less than or equal to 50 cells/μl had high prevalence of CNS diseases. Brain MRI plays an important role in the diagnosis and differentiation of CNS diseases in advanced AIDS patients. This study suggests patients with low CD4+T cell count (≤ 50/μl) should routinely undergo MRI examination.

  4. Proceedings of the 3rd Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2015: advancing efficient methodologies through community partnerships and team science

    Kerns, Suzanne; Puspitasari, Ajeng; Hendricks, Karin; Pierson, Andria; Fizur, Phil; Comtois, Katherine A.; Green, Amy E; Trott, Elise M.; Willging, Cathleen E.; Fernandez, Maria E.; Woolf, Nicholas H.; Liang, Shuting Lily; Heredia, Natalia I.; Kegler, Michelle; Risendal, Betsy


    Table of contents Introduction to the 3rd Biennial Conference of the Society for Implementation Research Collaboration: advancing efficient methodologies through team science and community partnerships Cara Lewis, Doyanne Darnell, Suzanne Kerns, Maria Monroe-DeVita, Sara J. Landes, Aaron R. Lyon, Cameo Stanick, Shannon Dorsey, Jill Locke, Brigid Marriott, Ajeng Puspitasari, Caitlin Dorsey, Karin Hendricks, Andria Pierson, Phil Fizur, Katherine A. Comtois A1: A behavioral economic perspective ...

  5. Proceedings of the 3rd Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2015: advancing efficient methodologies through community partnerships and team science

    Kerns, Suzanne; Puspitasari, Ajeng; Hendricks, Karin; Pierson, Andria; Fizur, Phil; Comtois, Katherine A.; Green, Amy E.; Trott, Elise M.; Willging, Cathleen E.; Fernandez, Maria E.; Woolf, Nicholas H.; Liang, Shuting Lily; Heredia, Natalia I.; Kegler, Michelle; Risendal, Betsy


    Table of contents Introduction to the 3rd Biennial Conference of the Society for Implementation Research Collaboration: advancing efficient methodologies through team science and community partnerships Cara Lewis, Doyanne Darnell, Suzanne Kerns, Maria Monroe-DeVita, Sara J. Landes, Aaron R. Lyon, Cameo Stanick, Shannon Dorsey, Jill Locke, Brigid Marriott, Ajeng Puspitasari, Caitlin Dorsey, Karin Hendricks, Andria Pierson, Phil Fizur, Katherine A. Comtois A1: A behavioral economic perspective ...

  6. Development and applications of methodologies for the neutronic design of the Pebble Bed Advanced High Temperature Reactor (PB-AHTR)

    Fratoni, Massimiliano

    This study investigated the neutronic characteristics of the Pebble Bed Advanced High Temperature Reactor (PB-AHTR), a novel nuclear reactor concept that combines liquid salt (7LiF-BeF2---flibe) cooling and TRISO coated-particle fuel technology. The use of flibe enables operation at high power density and atmospheric pressure and improves passive decay-heat removal capabilities, but flibe, unlike conventional helium coolant, is not transparent to neutrons. The flibe occupies 40% of the PB-AHTR core volume and absorbs ˜8% of the neutrons, but also acts as an effective neutron moderator. Two novel methodologies were developed for calculating the time dependent and equilibrium core composition: (1) a simplified single pebble model that is relatively fast; (2) a full 3D core model that is accurate and flexible but computationally intensive. A parametric analysis was performed spanning a wide range of fuel kernel diameters and graphite-to-heavy metal atom ratios to determine the attainable burnup and reactivity coefficients. Using 10% enriched uranium ˜130 GWd/tHM burnup was found to be attainable, when the graphite-to-heavy metal atom ratio (C/HM) is in the range of 300 to 400. At this or smaller C/HM ratio all reactivity coefficients examined---coolant temperature, coolant small and full void, fuel temperature, and moderator temperature, were found to be negative. The PB-AHTR performance was compared to that of alternative options for HTRs, including the helium-cooled pebble-bed reactor and prismatic fuel reactors, both gas-cooled and flibe-cooled. The attainable burnup of all designs was found to be similar. The PB-AHTR generates at least 30% more energy per pebble than the He-cooled pebble-bed reactor. Compared to LWRs the PB-AHTR requires 30% less natural uranium and 20% less separative work per unit of electricity generated. For deep burn TRU fuel made from recycled LWR spent fuel, it was found that in a single pass through the core ˜66% of the TRU can be

  7. Ultrasound-guided diagnostic breast biopsy methodology: retrospective comparison of the 8-gauge vacuum-assisted biopsy approach versus the spring-loaded 14-gauge core biopsy approach

    Jimenez Rafael E; Povoski Stephen P; Wang Wenle P


    Abstract Background Ultrasound-guided diagnostic breast biopsy technology represents the current standard of care for the evaluation of indeterminate and suspicious lesions seen on diagnostic breast ultrasound. Yet, there remains much debate as to which particular method of ultrasound-guided diagnostic breast biopsy provides the most accurate and optimal diagnostic information. The aim of the current study was to compare and contrast the 8-gauge vacuum-assisted biopsy approach and the spring-...

  8. A preface on advances in diagnostics for infectious and parasitic diseases: detecting parasites of medical and veterinary importance.

    Stothard, J Russell; Adams, Emily


    There are many reasons why detection of parasites of medical and veterinary importance is vital and where novel diagnostic and surveillance tools are required. From a medical perspective alone, these originate from a desire for better clinical management and rational use of medications. Diagnosis can be at the individual-level, at close to patient settings in testing a clinical suspicion or at the community-level, perhaps in front of a computer screen, in classification of endemic areas and devising appropriate control interventions. Thus diagnostics for parasitic diseases has a broad remit as parasites are not only tied with their definitive hosts but also in some cases with their vectors/intermediate hosts. Application of current diagnostic tools and decision algorithms in sustaining control programmes, or in elimination settings, can be problematic and even ill-fitting. For example in resource-limited settings, are current diagnostic tools sufficiently robust for operational use at scale or are they confounded by on-the-ground realities; are the diagnostic algorithms underlying public health interventions always understood and well-received within communities which are targeted for control? Within this Special Issue (SI) covering a variety of diseases and diagnostic settings some answers are forthcoming. An important theme, however, throughout the SI is to acknowledge that cross-talk and continuous feedback between development and application of diagnostic tests is crucial if they are to be used effectively and appropriately.

  9. Comparison of Established Diagnostic Methodologies and a Novel Bacterial smpB Real-Time PCR Assay for Specific Detection of Haemophilus influenzae Isolates Associated with Respiratory Tract Infections.

    Reddington, Kate; Schwenk, Stefan; Tuite, Nina; Platt, Gareth; Davar, Danesh; Coughlan, Helena; Personne, Yoann; Gant, Vanya; Enne, Virve I; Zumla, Alimuddin; Barry, Thomas


    Haemophilus influenzae is a significant causative agent of respiratory tract infections (RTI) worldwide. The development of a rapid H. influenzae diagnostic assay that would allow for the implementation of infection control measures and also improve antimicrobial stewardship for patients is required. A number of nucleic acid diagnostics approaches that detect H. influenzae in RTIs have been described in the literature; however, there are reported specificity and sensitivity limitations for these assays. In this study, a novel real-time PCR diagnostic assay targeting the smpB gene was designed to detect all serogroups of H. influenzae. The assay was validated using a panel of well-characterized Haemophilus spp. Subsequently, 44 Haemophilus clinical isolates were collected, and 36 isolates were identified as H. influenzae using a gold standard methodology that combined the results of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and a fucK diagnostic assay. Using the novel smpB diagnostic assay, 100% concordance was observed with the gold standard, demonstrating a sensitivity of 100% (95% confidence interval [CI], 90.26% to 100.00%) and a specificity of 100% (95% CI, 63.06% to 100.00%) when used on clinical isolates. To demonstrate the clinical utility of the diagnostic assay presented, a panel of lower RTI samples (n = 98) were blindly tested with the gold standard and smpB diagnostic assays. The results generated were concordant for 94/98 samples tested, demonstrating a sensitivity of 90.91% (95% CI, 78.33% to 97.47%) and a specificity of 100% (95% CI, 93.40% to 100.00%) for the novel smpB assay when used directly on respiratory specimens.

  10. Advancing absolute sustainability assessments of products with a new Planetary Boundaries based life-cycle impact assessment methodology

    Ryberg, Morten; Owsianiak, Mikolaj; Richardson, Katherine

    an operational life-cycle impact assessment (LCIA) methodology where the definition of the impact categories is based on the control variables as defined in the PB-framework by Steffen et al (2015). This included the development and calculation of characterization factors for the Earth System processes......The Planetary Boundaries (PB)-framework introduced quantitative boundaries for a set of biophysical Earth System processes. The PBs delimit a ‘safe operating space' for humanity to act within to keep Earth in a Holocene-like state (Rockström et al 2009). The concept has gained strong interest from...

  11. Ultrasound-guided diagnostic breast biopsy methodology: retrospective comparison of the 8-gauge vacuum-assisted biopsy approach versus the spring-loaded 14-gauge core biopsy approach


    Background Ultrasound-guided diagnostic breast biopsy technology represents the current standard of care for the evaluation of indeterminate and suspicious lesions seen on diagnostic breast ultrasound. Yet, there remains much debate as to which particular method of ultrasound-guided diagnostic breast biopsy provides the most accurate and optimal diagnostic information. The aim of the current study was to compare and contrast the 8-gauge vacuum-assisted biopsy approach and the spring-loaded 14-gauge core biopsy approach. Methods A retrospective analysis was done of all ultrasound-guided diagnostic breast biopsy procedures performed by either the 8-gauge vacuum-assisted biopsy approach or the spring-loaded 14-gauge core biopsy approach by a single surgeon from July 2001 through June 2009. Results Among 1443 ultrasound-guided diagnostic breast biopsy procedures performed, 724 (50.2%) were by the 8-gauge vacuum-assisted biopsy technique and 719 (49.8%) were by the spring-loaded 14-gauge core biopsy technique. The total number of false negative cases (i.e., benign findings instead of invasive breast carcinoma) was significantly greater (P = 0.008) in the spring-loaded 14-gauge core biopsy group (8/681, 1.2%) as compared to in the 8-gauge vacuum-assisted biopsy group (0/652, 0%), with an overall false negative rate of 2.1% (8/386) for the spring-loaded 14-gauge core biopsy group as compared to 0% (0/148) for the 8-gauge vacuum-assisted biopsy group. Significantly more (P biopsy group (81/719, 11.3%) than in the 8-gauge vacuum-assisted biopsy group (18/724, 2.5%) were recommended for further diagnostic surgical removal of additional tissue from the same anatomical site of the affected breast in an immediate fashion for indeterminate/inconclusive findings seen on the original ultrasound-guided diagnostic breast biopsy procedure. Significantly more (P biopsy group (54/719, 7.5%) than in the 8-gauge vacuum-assisted biopsy group (9/724, 1.2%) personally requested further

  12. Encouraging the pursuit of advanced degrees in science and engineering: Top-down and bottom-up methodologies

    Maddox, Anthony B.; Smith-Maddox, Renee P.; Penick, Benson E.


    The MassPEP/NASA Graduate Research Development Program (GRDP) whose objective is to encourage Black Americans, Mexican Americans, American Indians, Puerto Ricans, and Pacific Islanders to pursue graduate degrees in science and engineering is described. The GRDP employs a top-down or goal driven methodology through five modules which focus on research, graduate school climate, technical writing, standardized examinations, and electronic networking. These modules are designed to develop and reinforce some of the skills necessary to seriously consider the goal of completing a graduate education. The GRDP is a community-based program which seeks to recruit twenty participants from a pool of Boston-area undergraduates enrolled in engineering and science curriculums and recent graduates with engineering and science degrees. The program emphasizes that with sufficient information, its participants can overcome most of the barriers perceived as preventing them from obtaining graduate science and engineering degrees. Experience has shown that the top-down modules may be complemented by a more bottom-up or event-driven methodology. This approach considers events in the academic and professional experiences of participants in order to develop the personal and leadership skills necessary for graduate school and similar endeavors.

  13. Advancing the Use of Evidence-Based Decision-Making in Local Health Departments With Systems Science Methodologies

    Li, Yan; Kong, Nan; Lawley, Mark; Weiss, Linda


    Objectives. We assessed how systems science methodologies might be used to bridge resource gaps at local health departments (LHDs) so that they might better implement evidence-based decision-making (EBDM) to address population health challenges. Methods. We used the New York Academy of Medicine Cardiovascular Health Simulation Model to evaluate the results of a hypothetical program that would reduce the proportion of people smoking, eating fewer than 5 fruits and vegetables per day, being physically active less than 150 minutes per week, and who had a body mass index (BMI) of 25 kg/m2 or greater. We used survey data from the Behavioral Risk Factor Surveillance System to evaluate health outcomes and validate simulation results. Results. Smoking rates and the proportion of the population with a BMI of 25 kg/m2 or greater would have decreased significantly with implementation of the hypothetical program (P < .001). Two areas would have experienced a statistically significant reduction in the local population with diabetes between 2007 and 2027 (P < .05). Conclusions. The use of systems science methodologies might be a novel and efficient way to systematically address a number of EBDM adoption barriers at LHDs. PMID:25689181

  14. Equipment concept design and development plans for microgravity science and applications research on space station: Combustion tunnel, laser diagnostic system, advanced modular furnace, integrated electronics laboratory

    Uhran, M. L.; Youngblood, W. W.; Georgekutty, T.; Fiske, M. R.; Wear, W. O.


    Taking advantage of the microgravity environment of space NASA has initiated the preliminary design of a permanently manned space station that will support technological advances in process science and stimulate the development of new and improved materials having applications across the commercial spectrum. Previous studies have been performed to define from the researcher's perspective, the requirements for laboratory equipment to accommodate microgravity experiments on the space station. Functional requirements for the identified experimental apparatus and support equipment were determined. From these hardware requirements, several items were selected for concept designs and subsequent formulation of development plans. This report documents the concept designs and development plans for two items of experiment apparatus - the Combustion Tunnel and the Advanced Modular Furnace, and two items of support equipment the Laser Diagnostic System and the Integrated Electronics Laboratory. For each concept design, key technology developments were identified that are required to enable or enhance the development of the respective hardware.

  15. Screening for colorectal cancer and advanced colorectal neoplasia in kidney transplant recipients: cross sectional prevalence and diagnostic accuracy study of faecal immunochemical testing for haemoglobin and colonoscopy.

    Collins, Michael G; Teo, Edward; Cole, Stephen R; Chan, Choy-Yoke; McDonald, Stephen P; Russ, Graeme R; Young, Graeme P; Bampton, Peter A; Coates, P Toby


    To investigate whether screening kidney transplant recipients aged over 50 years for colorectal cancer with a faecal immunochemical test for haemoglobin might be justified, by determining the prevalence of advanced colorectal neoplasia and evaluating the diagnostic accuracy of faecal haemoglobin testing compared with colonoscopy in a population of kidney transplant recipients at otherwise average risk. Cross sectional prevalence and diagnostic accuracy study with index test of faecal haemoglobin and reference standard of colonoscopy. Outpatient clinics in metropolitan and regional hospitals in South Australia. 229 kidney transplant recipients aged 50 years and over, who were at least 6 months (mean 9.0 (SD 8.4) years) post-transplant and otherwise at average risk of colorectal cancer, completed the study between June 2008 and October 2011. Faecal immunochemical testing (Enterix Insure) for human haemoglobin, followed by colonoscopy with histological evaluation of retrieved samples. Prevalence of advanced colorectal neoplasia, defined as an adenoma at least 10 mm in diameter, villous features, high grade dysplasia, or colorectal cancer; sensitivity, specificity, and predictive values of faecal haemoglobin testing for advanced neoplasia compared with colonoscopy. Advanced colorectal neoplasia was found in 29 (13%, 95% confidence interval 9% to 18%) participants, including 2% (n=4) with high grade dysplasia and 2% (n=5) with colorectal cancer. Faecal testing for haemoglobin was positive in 12% (n=28); sensitivity, specificity, and positive and negative predictive values for advanced neoplasia were 31.0% (15.3% to 50.8%), 90.5% (85.6% to 94.2%), 32.1% (15.9% to 52.4%), and 90.1% (85.1% to 93.8%). Colonoscopy was well tolerated, with no significant adverse outcomes. To identify one case of advanced neoplasia, 8 (6 to 12) colonoscopies were needed. Kidney transplant recipients aged over 50 years have a high prevalence of advanced colorectal neoplasia. Faecal haemoglobin

  16. Advances in diagnostic techniques of toxoplasmosis%弓形虫病诊断方法研究进展

    冯嘉轩; 赵永坤; 孟繁平; 吴泽民; 刘智; 李娜; 刘全


    Toxoplasmosis is a severe parasitic zoonosis caused byToxoplasma gondii, which poses a threat to human health. In this paper, the diagnostic techniques of toxoplasmosis and detection methods ofT. gondii were reviewed, including non-DNA-based diagnostic methods, serological assays, and molecular methods based on detection of parasite nucleic acid in hope of providing an insight into the development of novel diagnostic technologies and methods of toxoplasmosis.%弓形虫病是由弓形虫感染引起的一种严重的人兽共患寄生虫病,对人类健康造成极大威胁。本文对弓形虫病诊断技术,包括不依赖DNA检测诊断方法、血清学检测以及基于寄生虫核酸的分子生物学方法进行综述,为弓形虫病诊断技术和方法的发展提供新的思路。

  17. Advanced self-healing asphalt composites in the pavement performance field: mechanisms at the nano level and new repairing methodologies.

    Agzenai, Yahya; Pozuelo, Javier; Sanz, Javier; Perez, Ignacio; Baselga, Juan


    In an effort to give a global view of this field of research, in this mini-review we highlight the most recent publications and patents focusing on modified asphalt pavements that contain certain reinforcing nanoparticles which impart desirable thermal, electrical and mechanical properties. In response to the increasing cost of asphalt binder and road maintenance, there is a need to look for alternative technologies and new asphalt composites, able to self-repair, for preserving and renewing the existing pavements. First, we will focus on the self-healing property of asphalt, the evidences that support that healing takes place immediately after the contact between the faces of a crack, and how the amount of healing can be measured in both the laboratory and the field. Next we review the hypothetical mechanisms of healing to understand the material behaviour and establish models to quantify the damage-healing process. Thereafter, we outline different technologies, nanotechnologies and methodologies used for self-healing paying particular attention to embedded micro-capsules, new nano-materials like carbon nanotubes and nano-fibres, ionomers, and microwave and induction heating processes.

  18. Advanced design methodology for single and dual voltage wound core power transformers based on a particular finite element model

    Tsili, Marina A.; Kladas, Antonios G. [Faculty of Electrical & amp; Computer Engineering, National Technical University of Athens, GR-15780, Athens (Greece); Georgilakis, Pavlos S. [Department of Production Engineering and Management, Technical University of Crete, GR-73100, Chania (Greece); Souflaris, Athanasios T.; Paparigas, Dimitris G. [Schneider Electric AE, Elvim Plant, GR-32011, Inofyta, Viotia (Greece)


    The paper presents an accurate and cost effective three-dimensional finite element model for the analysis and design of wound core, shell type, power transformers, focusing on the short-circuit impedance evaluation. The model efficiency lies on the detailed representation of the transformer geometry along with the adoption of a particular reduced scalar potential formulation enabling three-dimensional magnetostatic problem solution without prior source field calculation. Its accuracy is validated through local field measurements and through comparison of the calculated short-circuit impedance value with the measured one for several commercial wound core, shell type transformers. In such transformers, involving extensive winding parts out of the core window, the detailed representation of the transformer geometry, including the winding cooling ducts, provides accurate results for low densities of the three-dimensional finite element mesh, resulting to reduction of the required calculation time. The model is used in the development of a computational tool, which enables the automated and accurate transformer characteristics prediction, adopted to the manufacturing process. This tool has also been applied in the impedance calculation for different winding connections of dual voltage transformers, thus providing the information needed for the achievement of an accurate design and the enhancement of the manufacturer's ability to reduce design margins. The methodology presented in this paper has been incorporated in the design process of a transformer manufacturing industry. (author)

  19. Simple Response Surface Methodology: Investigation on Advance Photocatalytic Oxidation of 4-Chlorophenoxyacetic Acid Using UV-Active ZnO Photocatalyst

    Kian Mun Lee


    Full Text Available The performance of advance photocatalytic degradation of 4-chlorophenoxyacetic acid (4-CPA strongly depends on photocatalyst dosage, initial concentration and initial pH. In the present study, a simple response surface methodology (RSM was applied to investigate the interaction between these three independent factors. Thus, the photocatalytic degradation of 4-CPA in aqueous medium assisted by ultraviolet-active ZnO photocatalyst was systematically investigated. This study aims to determine the optimum processing parameters to maximize 4-CPA degradation. Based on the results obtained, it was found that a maximum of 91% of 4-CPA was successfully degraded under optimal conditions (0.02 g ZnO dosage, 20.00 mg/L of 4-CPA and pH 7.71. All the experimental data showed good agreement with the predicted results obtained from statistical analysis.

  20. Advancing the Potential of Citizen Science for Urban Water Quality Monitoring: Exploring Research Design and Methodology in New York City

    Hsueh, D.; Farnham, D. J.; Gibson, R.; McGillis, W. R.; Culligan, P. J.; Cooper, C.; Larson, L.; Mailloux, B. J.; Buchanan, R.; Borus, N.; Zain, N.; Eddowes, D.; Butkiewicz, L.; Loiselle, S. A.


    Citizen Science is a fast-growing ecological research tool with proven potential to rapidly produce large datasets. While the fields of astronomy and ornithology demonstrate particularly successful histories of enlisting the public in conducting scientific work, citizen science applications to the field of hydrology have been relatively underutilized. We demonstrate the potential of citizen science for monitoring water quality, particularly in the impervious, urban environment of New York City (NYC) where pollution via stormwater runoff is a leading source of waterway contamination. Through partnerships with HSBC, Earthwatch, and the NYC Water Trail Association, we have trained two citizen science communities to monitor the quality of NYC waterways, testing for a suite of water quality parameters including pH, turbidity, phosphate, nitrate, and Enterococci (an indicator bacteria for the presence of harmful pathogens associated with fecal pollution). We continue to enhance these citizen science programs with two additions to our methodology. First, we designed and produced at-home incubation ovens for Enterococci analysis, and second, we are developing automated photo-imaging for nitrate and phosphate concentrations. These improvements make our work more publicly accessible while maintaining scientific accuracy. We also initiated a volunteer survey assessing the motivations for participation among our citizen scientists. These three endeavors will inform future applications of citizen science for urban hydrological research. Ultimately, the spatiotemporally-rich dataset of waterway quality produced from our citizen science efforts will help advise NYC policy makers about the impacts of green infrastructure and other types of government-led efforts to clean up NYC waterways.

  1. Advanced methodology for measuring the extensive elastic compliance and mechanical loss directly in k31 mode piezoelectric ceramic plates

    Majzoubi, Maryam; Shekhani, Husain N.; Bansal, Anushka; Hennig, Eberhard; Scholehwar, Timo; Uchino, Kenji


    Dielectric, elastic, and piezoelectric constants, and their corresponding losses are defined under constant conditions of two categories; namely, intensive (i.e., E, electric field or T, stress), and extensive (i.e., D, dielectric displacement or x, strain) ones. So far, only the intensive parameters and losses could be measured directly in a k31 mode sample. Their corresponding extensive parameters could be calculated indirectly using the coupling factor and "K" matrix. However, the extensive loss parameters, calculated through this indirect method, could have large uncertainty, due to the error propagation in calculation. In order to overcome this issue, extensive losses should be measured separately from the measurable intensive ones in lead-zirconate-titanate (PZT) k31 mode rectangular plate ceramics. We propose a new mechanical-excitation methodology, using a non-destructive testing approach by means of a partial electrode configuration, instead of the conventional full electrode configuration. For this purpose, a non-electrode sample was prepared, where the electrode covered only 10% of the top and bottom surfaces at the center to actuate the whole sample, and also monitor the responding vibration. The admittance spectrum of this sample, corresponds to PZT properties under dielectric displacement D constant condition. Furthermore, ceramics with partial-electrodes were also prepared to create short and open circuit boundary conditions, attributing to resonance and anti-resonance modes. In the proposed way, we were able to measure both intensive and extensive elastic compliances and mechanical losses directly for the first time. The accuracy of this new method is compared with the conventional measurements by use of indirect calculations. The preliminary results (by neglecting the 10% actuator part difference at this point) were obtained, which were in good agreements (less than 3% difference) with the previous indirect method.

  2. Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors

    Mobarec, Juan Carlos


    Background Despite the large amount of experimental data accumulated in the past decade on G-protein coupled receptor (GPCR) structure and function, understanding of the molecular mechanisms underlying GPCR signaling is still far from being complete, thus impairing the design of effective and selective pharmaceuticals. Objective Understanding of GPCR function has been challenged even further by more recent experimental evidence that several of these receptors are organized in the cell membrane as homo- or hetero-oligomers, and that they may exhibit unique pharmacological properties. Given the complexity of these new signaling systems, researcher’s efforts are turning increasingly to molecular modeling, bioinformatics and computational simulations for mechanistic insights of GPCR functional plasticity. Methods We review here current advances in the development and application of computational approaches to improve prediction of GPCR structure and dynamics, thus enhancing current understanding of GPCR signaling. Results/Conclusions Models resulting from use of these computational approaches further supported by experiments are expected to help elucidate the complex allosterism that propagates through GPCR complexes, ultimately aiming at successful structure-based rational drug design. PMID:19672320

  3. Advances in analytical methodology for bioinorganic speciation analysis: metallomics, metalloproteomics and heteroatom-tagged proteomics and metabolomics.

    Szpunar, Joanna


    The recent developments in analytical techniques capable of providing information on the identity and quantity of heteroatom-containing biomolecules are critically discussed. Particular attention is paid to the emerging areas of bioinorganic analysis including: (i) a comprehensive analysis of the entirety of metal and metalloid species within a cell or tissue type (metallomics), (ii) the study of the part of the metallome involving the protein ligands (metalloproteomics), and (iii) the use of a heteroelement, naturally present in a protein or introduced in a tag added by means of derivatisation, for the spotting and quantification of proteins (heteroatom-tagged proteomics). Inductively coupled plasma mass spectrometry (ICP MS), used as detector in chromatography and electrophoresis, and supported by electrospray and MALDI MS, appears as the linchpin analytical technique for these emerging areas. This review focuses on the recent advances in ICP MS in biological speciation analysis including sensitive detection of non-metals, especially of sulfur and phosphorus, couplings to capillary and nanoflow HPLC and capillary electrophoresis, laser ablation ICP MS detection of proteins in gel electrophoresis, and isotope dilution quantification of biomolecules. The paper can be considered as a followup of a previous review by the author on a similar topic (J. Szpunar, Analyst, 2000, 125, 963).

  4. Heating, Ventilating, and Air-Conditioning: Recent Advances in Diagnostics and Controls to Improve Air-Handling System Performance

    Wray, Craig; Wray, Craig P.; Sherman, Max H.; Walker, I.S.; Dickerhoff, D.J.; Federspiel, C.C.


    The performance of air-handling systems in buildings needs to be improved. Many of the deficiencies result from myths and lore and a lack of understanding about the non-linear physical principles embedded in the associated technologies. By incorporating these principles, a few important efforts related to diagnostics and controls have already begun to solve some of the problems. This paper illustrates three novel solutions: one rapidly assesses duct leakage, the second configures ad hoc duct-static-pressure reset strategies, and the third identifies useful intermittent ventilation strategies. By highlighting these efforts, this paper seeks to stimulate new research and technology developments that could further improve air-handling systems.

  5. Development of Serum Marker Models to Increase Diagnostic Accuracy of Advanced Fibrosis in Nonalcoholic Fatty Liver Disease: The New LINKI Algorithm Compared with Established Algorithms

    Lykiardopoulos, Byron; Hagström, Hannes; Fredrikson, Mats; Ignatova, Simone; Stål, Per; Hultcrantz, Rolf; Ekstedt, Mattias


    Background and Aim Detection of advanced fibrosis (F3-F4) in nonalcoholic fatty liver disease (NAFLD) is important for ascertaining prognosis. Serum markers have been proposed as alternatives to biopsy. We attempted to develop a novel algorithm for detection of advanced fibrosis based on a more efficient combination of serological markers and to compare this with established algorithms. Methods We included 158 patients with biopsy-proven NAFLD. Of these, 38 had advanced fibrosis. The following fibrosis algorithms were calculated: NAFLD fibrosis score, BARD, NIKEI, NASH-CRN regression score, APRI, FIB-4, King´s score, GUCI, Lok index, Forns score, and ELF. Study population was randomly divided in a training and a validation group. A multiple logistic regression analysis using bootstrapping methods was applied to the training group. Among many variables analyzed age, fasting glucose, hyaluronic acid and AST were included, and a model (LINKI-1) for predicting advanced fibrosis was created. Moreover, these variables were combined with platelet count in a mathematical way exaggerating the opposing effects, and alternative models (LINKI-2) were also created. Models were compared using area under the receiver operator characteristic curves (AUROC). Results Of established algorithms FIB-4 and King´s score had the best diagnostic accuracy with AUROCs 0.84 and 0.83, respectively. Higher accuracy was achieved with the novel LINKI algorithms. AUROCs in the total cohort for LINKI-1 was 0.91 and for LINKI-2 models 0.89. Conclusion The LINKI algorithms for detection of advanced fibrosis in NAFLD showed better accuracy than established algorithms and should be validated in further studies including larger cohorts. PMID:27936091

  6. A three-dimensional methodology for the assessment of neutron damage and nuclear energy deposition in graphite components of advanced gas-cooled reactors

    Morgan, D.O.; Robinson, A.T.; Allen, D.A.; Picton, D.J.; Thornton, D.A. [TCS, Serco, Rutherford House, Olympus Park, Quedgeley, Gloucester, Gloucestershire GL2 4NF (United Kingdom); Shaw, S.E. [EDF Energy, Barnet Way, Barnwood, Gloucester GL4 3RS (United Kingdom)


    This paper describes the development of a three-dimensional methodology for the assessment of neutron damage and nuclear energy deposition (or nuclear heating) throughout the graphite cores of the UK's Advanced Gas-cooled Reactors. Advances in the development of the Monte Carlo radiation transport code MCBEND have enabled the efficient production of detailed fully three-dimensional models that utilise three-dimensional source distributions obtained from Core Follow data supplied by the reactor physics code PANTHER. The calculational approach can be simplified to reduce both the requisite number of intensive radiation transport calculations, as well as the quantity of data output. These simplifications have been qualified by comparison with explicit calculations and they have been shown not to introduce significant systematic uncertainties. Simple calculational approaches are described that allow users of the data to address the effects on neutron damage and nuclear energy deposition predictions of the feedback resulting from the mutual dependencies of graphite weight loss and nuclear energy deposition. (authors)

  7. Evaluation of an advanced-practice physical therapist in a specialty shoulder clinic: diagnostic agreement and effect on wait times.

    Razmjou, Helen; Robarts, Susan; Kennedy, Deborah; McKnight, Cheryl; Macleod, Anne Marie; Holtby, Richard


    Objectif : Examiner le rôle du physiothérapeute en pratique avancée en ce qui a trait (1) aux accords avec un chirurgien orthopédique sur le diagnostic et la gestion de patients aux prises avec des problèmes à l'épaule; (2) au temps d'attente; (3) à la satisfaction par rapport aux soins. Méthode : Cette étude prospective a fait appel à des patients avec des douleurs à l'épaule qui ont été dirigés vers des spécialistes de l'épaule dans un centre de soins tertiaires. Les accords ont été examinés pour sept catégories de diagnostics, en fonction de la nécessité d'examens plus poussés ou de chirurgie et du type d'intervention chirurgicale projeté. On a comparé les temps d'attente pour le physiothérapeute en pratique avancée et les cliniques dirigées par un chirurgien à partir de la date où le patient a été redirigé à la consultation initiale, jusqu'à la date de diagnostic définitif, jusqu'à la date de diagnostic confirmé et jusqu'au traitement planifié. Une version modifiée et validée de l'instrument d'évaluation de la satisfaction à la suite d'une consultation (Visit-Specific Satisfaction Instrument) a permis de mesurer la satisfaction dans sept domaines. Les coefficients kappa (κ) et les valeurs kappa ajustées pour la prévalence et le biais (PABAK) ont été calculés et les accords ont été catégorisés selon leur force. Les données sur les temps d'attente et la satisfaction ont été examinées à l'aide de statistiques non paramétriques. Résultats : Le degré d'accord sur les diagnostics importants variait de 0,68 (bon) à 0,96 (excellent). Les accords en ce qui concerne le recours à la chirurgie étaient de κ=0,75, p<0,001, I.C. 95%, 0,62–0,88 (bon). Les temps d'attente pour une évaluation par un physiothérapeute en pratique avancée étaient considérablement plus courts que ceux pour une consultation auprès d'un chirurgien à toutes les étapes (p<0,001); les temps d'attente pour un chirurgien

  8. On the extension of modern best-estimate plus uncertainy methodologies to future fast reactor and advanced fuel licensing - initial evaluation of issues

    Unal, Cetin [Los Alamos National Laboratory; Mcclure, Patrick R [Los Alamos National Laboratory


    and has precedence in the NRC. The method is generically referred to as a 'Best Estimate plus Uncertainty' approach (BE+U), since the goal of the methodology is to compare the model value (best estimate) plus any uncertainty to a figure of merit like cladding temperature. The challenges for extending the BE+U (1) method for fuel qualification for an Advanced Reactor Fuel are driven by: schedule, the need for data, the data sufficiency, the identification of important phenomenon, the process of validation (with focus on the multi-scale model), and the need to produce and extended best estimate plus uncertainty methodology. This paper examines these issues an offers up a proposed set of methods that extend the current BE+U methodology address most if not all of these challenges.

  9. An Applied Study of Implementation of the Advanced Decommissioning Costing Methodology for Intermediate Storage Facility for Spent Fuel in Studsvik, Sweden with special emphasis to the application of the Omega code

    Kristofova, Kristina; Vasko, Marek; Daniska, Vladimir; Ondra, Frantisek; Bezak, Peter [DECOM Slovakia, spol. s.r.o., J. Bottu 2, SK-917 01 Trnava (Slovakia); Lindskog, Staffan [Swedish Nuclear Power Inspectorate, Stockholm (Sweden)


    The presented study is focused on an analysis of decommissioning costs for the Intermediate Storage Facility for Spent Fuel (FA) facility in Studsvik prepared by SVAFO and a proposal of the advanced decommissioning costing methodology application. Therefore, this applied study concentrates particularly in the following areas: 1. Analysis of FA facility cost estimates prepared by SVAFO including description of FA facility in Studsvik, summarised input data, applied cost estimates methodology and summarised results from SVAFO study. 2. Discussion of results of the SVAFO analysis, proposals for enhanced cost estimating methodology and upgraded structure of inputs/outputs for decommissioning study for FA facility. 3. Review of costing methodologies with the special emphasis on the advanced costing methodology and cost calculation code OMEGA. 4. Discussion on implementation of the advanced costing methodology for FA facility in Studsvik together with: - identification of areas of implementation; - analyses of local decommissioning infrastructure; - adaptation of the data for the calculation database; - inventory database; and - implementation of the style of work with the computer code OMEGA.

  10. Upgrade of Langmuir probe diagnostic in ITER-like tungsten mono-block divertor on experimental advanced superconducting tokamak

    Xu, J. C.; Wang, L.; Xu, G. S.; Luo, G. N.; Yao, D. M.; Li, Q.; Cao, L.; Chen, L.; Zhang, W.; Liu, S. C.; Wang, H. Q.; Jia, M. N.; Feng, W.; Deng, G. Z.; Hu, L. Q.; Wan, B. N.; Li, J.; Sun, Y. W.; Guo, H. Y.


    In order to withstand rapid increase in particle and power impact onto the divertor and demonstrate the feasibility of the ITER design under long pulse operation, the upper divertor of the EAST tokamak has been upgraded to actively water-cooled, ITER-like tungsten mono-block structure since the 2014 campaign, which is the first attempt for ITER on the tokamak devices. Therefore, a new divertor Langmuir probe diagnostic system (DivLP) was designed and successfully upgraded on the tungsten divertor to obtain the plasma parameters in the divertor region such as electron temperature, electron density, particle and heat fluxes. More specifically, two identical triple probe arrays have been installed at two ports of different toroidal positions (112.5-deg separated toroidally), which can provide fundamental data to study the toroidal asymmetry of divertor power deposition and related 3-dimension (3D) physics, as induced by resonant magnetic perturbations, lower hybrid wave, and so on. The shape of graphite tip and fixed structure of the probe are designed according to the structure of the upper tungsten divertor. The ceramic support, small graphite tip, and proper connector installed make it possible to be successfully installed in the very narrow interval between the cassette body and tungsten mono-block, i.e., 13.5 mm. It was demonstrated during the 2014 and 2015 commissioning campaigns that the newly upgraded divertor Langmuir probe diagnostic system is successful. Representative experimental data are given and discussed for the DivLP measurements, then proving its availability and reliability.

  11. Development of methodology for alternative testing strategies for the assessment of the toxicological profile of nanoparticles used in medical diagnostics. NanoTEST - EC FP7 project

    Dusinska, Maria; Fjellsbo, Lise Maria; Heimstad, Eldbjorg; Harju, Mikael; Bartonova, Alena [Norwegian Institute for Air Research (Norway)], E-mail:; Tran, Lang [Institute of Occupational Medicine (United Kingdom); Juillerat-Jeanneret, Lucienne; Halamoda, Blanka [Centre Hospitalier Universitaire Vaudois (Switzerland); Marano, Francelyne; Boland, Sonja [University Paris Diderot Paris7 (France); Saunders, Margaret; Cartwright, Laura; Carreira, Sara; Thawley, Susan [University Hospitals Bristol NHS Foundation Trust (United Kingdom); Whelan, Maurice; Klein, Christoph [EC - Directorate General Joint Research Centre (Italy); Housiadas, Christos [National Centre for Scientific Research Demokritos (Greece); Volkovova, Katarina; Tulinska, Jana; Beno, Milan [Slovak Medical University (Slovakia)] (and others)


    Nanoparticles (NPs) have unique, potentially beneficial properties, but their possible impact on human health is still not known. The area of nanomedicine brings humans into direct contact with NPs and it is essential for both public confidence and the nanotech companies that appropriate risk assessments are undertaken in relation to health and safety. There is a pressing need to understand how engineered NPs can interact with the human body following exposure. The FP7 project NanoTEST ( addresses these requirements in relation to the toxicological profile of NPs used in medical diagnostics.

  12. Complex ultrasound diagnostic assessment of the results of neoadjuvant chemotherapy for locally advanced cervical cancer (Stages IIB–IIIB

    L. A. Ashrafyan


    Full Text Available Background. Current complex ultrasound diagnosis using novel imaging techniques can assess, to a high accuracy, different tumor parameters during neoadjuvant chemotherapy (NCT for locally advanced cervical cancer (CC (Stages IIB–IIB. This assessment is very important and necessary to define further treatment policy.Materials and methods. A total of 199 patients diagnosed with Stages IIB–IIIB CC, including 60 patients with Stage IIB (T2bN0M0, 4 with Stage IIIА (T3aN0M0, and 135 with Stage IIIВ (T2bN1M0, T3aN1M0, T3bN0–1M0 (according to the International Federationof Gynecology and Obstetrics (FIGO classification, who received NCT at Stage 1 of treatment, were examined. Complex ultrasound study was conducted before treatment initiation and after each NCT cycle. The therapeutic pathomorphism of a tumor was evaluated in surgically treated patients.Results. The criteria have been determined for evaluating the efficiency of NCT for locally advanced CC, which are based on current ultrasonographic techniques including B-mode, Doppler ultrasound (power, spectral, three-dimensional ones, as well as on the results of therapeutic pathomorphism.Conclusion. The criteria for evaluating the efficiency of NCT for CC should be based on current complex ultrasonographic techniques.

  13. Fast imaging diagnostics on the C-2U advanced beam-driven field-reversed configuration device

    Granstedt, E. M.; Petrov, P.; Knapp, K.; Cordero, M.; Patel, V.


    The C-2U device employed neutral beam injection, end-biasing, and various particle fueling techniques to sustain a Field-Reversed Configuration (FRC) plasma. As part of the diagnostic suite, two fast imaging instruments with radial and nearly axial plasma views were developed using a common camera platform. To achieve the necessary viewing geometry, imaging lenses were mounted behind re-entrant viewports attached to welded bellows. During gettering, the vacuum optics were retracted and isolated behind a gate valve permitting their removal if cleaning was necessary. The axial view incorporated a stainless-steel mirror in a protective cap assembly attached to the vacuum-side of the viewport. For each system, a custom lens-based, high-throughput optical periscope was designed to relay the plasma image about half a meter to a high-speed camera. Each instrument also contained a remote-controlled filter wheel, set between shots to isolate a particular hydrogen or impurity emission line. The design of the camera platform, imaging performance, and sample data for each view is presented.

  14. Fast imaging diagnostics on the C-2U advanced beam-driven field-reversed configuration device

    Granstedt, E. M., E-mail:; Petrov, P.; Knapp, K.; Cordero, M.; Patel, V. [Tri Alpha Energy, P.O. Box 7010, Rancho Santa Margarita, California 92688 (United States)


    The C-2U device employed neutral beam injection, end-biasing, and various particle fueling techniques to sustain a Field-Reversed Configuration (FRC) plasma. As part of the diagnostic suite, two fast imaging instruments with radial and nearly axial plasma views were developed using a common camera platform. To achieve the necessary viewing geometry, imaging lenses were mounted behind re-entrant viewports attached to welded bellows. During gettering, the vacuum optics were retracted and isolated behind a gate valve permitting their removal if cleaning was necessary. The axial view incorporated a stainless-steel mirror in a protective cap assembly attached to the vacuum-side of the viewport. For each system, a custom lens-based, high-throughput optical periscope was designed to relay the plasma image about half a meter to a high-speed camera. Each instrument also contained a remote-controlled filter wheel, set between shots to isolate a particular hydrogen or impurity emission line. The design of the camera platform, imaging performance, and sample data for each view is presented.

  15. A methodological framework to distinguish spectrum effects from spectrum biases and to assess diagnostic and screening test accuracy for patient populations: Application to the Papanicolaou cervical cancer smear test

    Coste Joël


    Full Text Available Abstract Background A spectrum effect was defined as differences in the sensitivity or specificity of a diagnostic test according to the patient's characteristics or disease features. A spectrum effect can lead to a spectrum bias when subgroup variations in sensitivity or specificity also affect the likelihood ratios and thus post-test probabilities. We propose and illustrate a methodological framework to distinguish spectrum effects from spectrum biases. Methods Data were collected for 1781 women having had a cervical smear test and colposcopy followed by biopsy if abnormalities were detected (the reference standard. Logistic models were constructed to evaluate both the sensitivity and specificity, and the likelihood ratios, of the test and to identify factors independently affecting the test's characteristics. Results For both tests, human papillomavirus test, study setting and age affected sensitivity or specificity of the smear test (spectrum effect, but only human papillomavirus test and study setting modified the likelihood ratios (spectrum bias for clinical reading, whereas only human papillomavirus test and age modified the likelihood ratios (spectrum bias for "optimized" interpretation. Conclusion Fitting sensitivity, specificity and likelihood ratios simultaneously allows the identification of covariates that independently affect diagnostic or screening test results and distinguishes spectrum effect from spectrum bias. We recommend this approach for the development of new tests, and for reporting test accuracy for different patient populations.

  16. A mathematical theory of shape and neuro-fuzzy methodology-based diagnostic analysis: a comparative study on early detection and treatment planning of brain cancer.

    Kar, Subrata; Majumder, D Dutta


    Investigation of brain cancer can detect the abnormal growth of tissue in the brain using computed tomography (CT) scans and magnetic resonance (MR) images of patients. The proposed method classifies brain cancer on shape-based feature extraction as either benign or malignant. The authors used input variables such as shape distance (SD) and shape similarity measure (SSM) in fuzzy tools, and used fuzzy rules to evaluate the risk status as an output variable. We presented a classifier neural network system (NNS), namely Levenberg-Marquardt (LM), which is a feed-forward back-propagation learning algorithm used to train the NN for the status of brain cancer, if any, and which achieved satisfactory performance with 100% accuracy. The proposed methodology is divided into three phases. First, we find the region of interest (ROI) in the brain to detect the tumors using CT and MR images. Second, we extract the shape-based features, like SD and SSM, and grade the brain tumors as benign or malignant with the concept of SD function and SSM as shape-based parameters. Third, we classify the brain cancers using neuro-fuzzy tools. In this experiment, we used a 16-sample database with SSM (μ) values and classified the benignancy or malignancy of the brain tumor lesions using the neuro-fuzzy system (NFS). We have developed a fuzzy expert system (FES) and NFS for early detection of brain cancer from CT and MR images. In this experiment, shape-based features, such as SD and SSM, were extracted from the ROI of brain tumor lesions. These shape-based features were considered as input variables and, using fuzzy rules, we were able to evaluate brain cancer risk values for each case. We used an NNS with LM, a feed-forward back-propagation learning algorithm, as a classifier for the diagnosis of brain cancer and achieved satisfactory performance with 100% accuracy. The proposed network was trained with MR image datasets of 16 cases. The 16 cases were fed to the ANN with 2 input neurons, one

  17. Energy storage capacitors: Aging and diagnostic approaches for life validation

    Sarjeant, W.J. [State Univ. of New York, Buffalo, NY (United States); Larson, D.W. [Lawrence Livermore National Lab., CA (United States); MacDougall, F.W. [Aerovox, Inc., New Bedford, MA (United States); Kohlberg, I. [I. Kohlberg Associates, Inc., Alexandria, VA (United States)


    Over the last decade, significant increases in capacitor reliability have been achieved through a combination of advanced manufacturing techniques, new materials, and diagnostic methodologies to provide requisite life-cycle reliability for high energy pulse applications. Recent innovations in analysis of aging, including dimensional analysis, are introduced for predicting component performance and fault tolerance. In addition, voltage scaling issues that may drive bank fault-tolerance performance are described.

  18. Advances in diagnostic tests for bacterial STDs Avances en las pruebas diagnósticas de ETS bacterianas

    Stephen A Morse


    Full Text Available Because of their asymptomatic nature and nonspecific symptoms, laboratory tests are often required to diagnose a sexually transmitted infection. Over the past few years, there have been advances in technology, such as the development of nucleic acid amplification assays, which have improved our ability to diagnose infections caused by Chlamydia trachomatis. The finding that nucleic acid amplification tests can detect more infected individuals and are useful in screening low prevalence populations, has led to the development of strategies designed to reduce the cost of these assays without significantly impacting their sensitivity. The development of new tests for the diagnosis of syphilis has gained momentum from the report of a synthetic VDRL antigen, which will result in better nontreponemal antibody tests for syphilis. In spite of the completion of the genome sequence of Treponema pallidum and its annotation, we are still unable to cultivate this microorganism in vitro. However, the molecular revolution has resulted in the development of PCR assays for detecting Treponema pallidum in various types of clinical specimens, and to the production of recombinant antigens for use in tests that detect treponemal-specific antibodies. Further research will improve the availability of low cost, sensitive tests for the diagnosis of sexually transmitted infections.Las pruebas de laboratorio son necesarias a menudo para el diagnóstico de las infecciones transmitidas sexualmente, debido a la naturaleza asintomática o a la presencia de síntomas inespecíficos de esas infecciones. En este sentido, durante los años relativamente recientes se han registrado importantes avances tecnológicos, como por ejemplo los ensayos de amplificación de ácidos nucleicos que han permitido una mejora en la posibilidad de diagnosticar las infecciones causadas por Chlamydia trachomatis. El descubrimiento de que las pruebas de amplificación de ácidos nucleicos permiten

  19. Recent advances in the use of laser-induced breakdown spectroscopy (LIBS) as a rapid point-of-care pathogen diagnostic

    Rehse, Steven J.; Miziolek, Andrzej W.


    Laser-induced breakdown spectroscopy (LIBS) has made tremendous progress in becoming a viable technology for rapid bacterial pathogen detection and identification. The significant advantages of LIBS include speed (sensitivity and specificity. Bacterial identifications are completely unaffected by environment, nutrition media, or state of growth and accurate diagnoses can be made on autoclaved or UV-irradiated specimens. Efficient discrimination of bacteria at the strain level has been demonstrated. A rapid urinary tract infection diagnosis has been simulated with no sample preparation and a one second diagnosis of a pathogen surrogate has been demonstrated using advanced chemometric analysis with a simple "stop-light" user interface. Stand-off bacterial identification at a 20-m distance has been demonstrated on a field-portable instrument. This technology could be implemented in doctors' offices, clinics, or hospital laboratories for point-of-care medical specimen analysis; mounted on military medical robotic platforms for in-the- field diagnostics; or used in stand-off configuration for remote sensing and detection.

  20. Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging

    Tomas Kazda


    Full Text Available The accurate identification of glioblastoma progression remains an unmet clinical need. The aim of this prospective single-institutional study is to determine and validate thresholds for the main metabolite concentrations obtained by MR spectroscopy (MRS and the values of the apparent diffusion coefficient (ADC to enable distinguishing tumor recurrence from pseudoprogression. Thirty-nine patients after the standard treatment of a glioblastoma underwent advanced imaging by MRS and ADC at the time of suspected recurrence — median time to progression was 6.7 months. The highest significant sensitivity and specificity to call the glioblastoma recurrence was observed for the total choline (tCho to total N-acetylaspartate (tNAA concentration ratio with the threshold ≥1.3 (sensitivity 100.0% and specificity 94.7%. The ADCmean value higher than 1313 × 10−6 mm2/s was associated with the pseudoprogression (sensitivity 98.3%, specificity 100.0%. The combination of MRS focused on the tCho/tNAA concentration ratio and the ADCmean value represents imaging methods applicable to early non-invasive differentiation between a glioblastoma recurrence and a pseudoprogression. However, the institutional definition and validation of thresholds for differential diagnostics is needed for the elimination of setup errors before implementation of these multimodal imaging techniques into clinical practice, as well as into clinical trials.

  1. Advanced diagnostic system for piston slap faults in IC engines, based on the non-stationary characteristics of the vibration signals

    Chen, Jian; Randall, Robert Bond; Peeters, Bart


    Artificial Neural Networks (ANNs) have the potential to solve the problem of automated diagnostics of piston slap faults, but the critical issue for the successful application of ANN is the training of the network by a large amount of data in various engine conditions (different speed/load conditions in normal condition, and with different locations/levels of faults). On the other hand, the latest simulation technology provides a useful alternative in that the effect of clearance changes may readily be explored without recourse to cutting metal, in order to create enough training data for the ANNs. In this paper, based on some existing simplified models of piston slap, an advanced multi-body dynamic simulation software was used to simulate piston slap faults with different speeds/loads and clearance conditions. Meanwhile, the simulation models were validated and updated by a series of experiments. Three-stage network systems are proposed to diagnose piston faults: fault detection, fault localisation and fault severity identification. Multi Layer Perceptron (MLP) networks were used in the detection stage and severity/prognosis stage and a Probabilistic Neural Network (PNN) was used to identify which cylinder has faults. Finally, it was demonstrated that the networks trained purely on simulated data can efficiently detect piston slap faults in real tests and identify the location and severity of the faults as well.

  2. Prevalence of rheumatic regional pain syndromes in Latin-American indigenous groups: a census study based on COPCORD methodology and syndrome-specific diagnostic criteria.

    Alvarez-Nemegyei, José; Peláez-Ballestas, Ingris; Goñi, Mario; Julián-Santiago, Flor; García-García, Conrado; Quintana, Rosana; Silvestre, Adriana M R; García-Olivera, Imelda; Mathern, Nora A; Loyola-Sanchez, Adalberto; Conti, Silvana; Sanabria, Alvaro J; Pons-Estel, Bernardo A


    This study assessed the overall and specific prevalence of the main rheumatic regional pain syndromes (RRPS) in four Latin-American indigenous groups. A Community Oriented Program for Control of Rheumatic Diseases (COPCORD) methodology-based census study was performed in 4240 adults (participation rate: 78.88 %) in four indigenous groups: Chontal (Oaxaca, Mexico, n = 124), Mixteco (Oaxaca, Mexico; n = 937), Maya-Yucateco (Yucatán, Mexico; n = 1523), and Qom (Rosario, Argentina; n = 1656). Subjects with musculoskeletal pain were identified using a cross-cultural, validated COPCORD questionnaire administered by bilingual personnel, and reviewed by general practitioners or rheumatologists using standardized case definitions for the 12 most frequent RRPS. The overall prevalence of RRPS was confirmed in 239 cases (5.64 %, 95 % CI: 4.98-6.37). The prevalence in each group was Chontal n = 19 (15.32 %, 95 % CI: 10.03-22.69); Maya-Yucateco n = 165 (10.83 %, 95 % CI: 9.37-12.49); Qom n = 48 (2.90 %, 95 % CI: 2.19-3.82); and Mixteco n = 7 (0.75 %, 95 % CI: 0.36-1.53). In the whole sample, the syndrome-specific prevalence was rotator cuff tendinopathy: 1.98 % (95 % CI: 1.60-2.45); lateral epicondylalgia: 0.83 % (95 % CI: 0.59-1.15); medial epicondylalgia: 0.73 % (95 % CI: 0.52-1.04); biceps tendinopathy: 0.71 % (95 % CI: 0.50-1.01); anserine syndrome: 0.64 % (95 % CI: 0.44-0.92); inferior heel pain: 0.61 % (95 % CI: 0.42-0.90); trochanteric syndrome: 0.49 % (95 % CI: 0.25-0.64); de Quervain's tendinopathy: 0.45 % (95 % CI: 0.29-0.70); trigger finger: 0.42 % (95 % CI: 0.27-0.67); carpal tunnel syndrome: 0.28 % (95 % CI: 0.16-0.49); Achilles tendinopathy (insertional): 0.12 % (95 % CI: 0.05-0.28); and Achilles tendinopathy (non-insertional): 0.07 % (95 % CI: 0.02-0.21). Leaving aside the comparison between Maya-Yucateco and Chontal groups (p = 0.18), we found significant differences (p < 0.001) in

  3. Thyroid diagnostics

    Scriba, P.C.; Boerner, W.; Emrich, S.; Gutekunst, R.; Herrmann, J.; Horn, K.; Klett, M.; Krueskemper, H.L.; Pfannenstiel, P.; Pickardt, C.R.


    None of the in-vitro and in-vivo methods listed permits on unambiguous diagnosis when applied alone, owing to the fact that similar or even identical findings are obtained for various individual parameters in different thyroid diseases. Further, especially the in-vitro tests are also subject to extrathyroidal effects which may mask the typical findings. The limited and varying specificity and sensitivity of the tests applied, as well as the falsification of results caused by the patients' idiosyncracies and the methodology, make it necessary to interpret and evaluate the in-vivo and in-vitro findings only if the clinical situation (anamnesis and physical examination) is known. For maximum diagnostic quality of the tests, the initial probability of the assumed type of thyroid disease must be increased (formulation of the clinical problem). The concepts of exclusion diagnosis and identification must be distinguished as well as the diagnosis of functional disturbances on the one hand and of thyroid diseases on the other. Both of this requires a qualified, specific and detailed anamnesis and examination procedure, and the clinical examination remains the obligatory basis of clinical diagnostics. In case of inexplicable discrepancies between the clinical manifestations and the findings obtained with specific methods, or between the findings obtained with a specific method, the patient should be referred to an expert institution, or the expert institution should be consulted.

  4. 高龄孕妇产前筛查与诊断分析%Prenatal diagnostic testing among women referred for advanced maternal age

    李东明; 黄海锋; 陶春凤


    Objective:To investigate the incidence of aneuploidies of chromosomal in pregnant women with advanced maternal age (AMA) as indicator for invasive diagnostic testing.Methods:The results of prenatal diagnosis and clinical data were collected retrospectively,according to the indicator for invasive diagnostic testing.Results:Among the 8771 cases,188 cases (2.14%) of a fetal with aneuploidies of chromosomal were diagnosed,which are trisomy 21 (111 cases),trisomy 18 (27 cases),47,XXY (15 cases),45,X (13 cases),47,XXX (11 cases),trisomy 13 (10 cases),47,XYY (1 case).The detective rate of fetal with aneuploidies of chromosomal was higher in noninvasive prenatal testing (91.677%),followed by Abnormal serum screening and ultrasound findings group (7.01%),abnormal ultrasonic findings group (6.57%),Abnormal serum screening group (1.60%).Conclusion:The incidence of aneuploidies of chromosomal in pregnant women with AMA was high.The incidence was higher in pregnancy with multiple abnormal screening indexes.%目的 了解不同产前诊断指征高龄孕妇的胎儿染色体非整倍体检出情况.方法 回顾分析高龄孕妇产前诊断结果及其临床资料,分析不同指征孕妇胎儿非整倍体发生率.结果 8771例子高龄孕妇中,检出胎儿染色体非整倍体188例(2.14%),其中21三体最多为111例,依次为18三体27例,47,XXY 15例,45,X 13例,47,XXX 11例,13三体10例,47,XYY 1例.无创产前筛查阳性检出率最高为91.67%,其次为血清学筛查高风险+超声异常发现(7.10%)、超声异常发现(6.57%)和血清学筛查高风险(1.60%).结论 高龄妊娠胎儿染色体非整倍体发生率高于一般人群,妊娠合并多项筛查指标异常时,胎儿染色体非整倍体发生的风险增加.

  5. Advanced Diagnostics for Reacting Flows


    Ingeniera Mecanica , 17-19 Dec. 1990, Zaragosa, Spain; published in Congress Proceedings. 19. D. F. Davidson, A. Y. Chang, M. D. DiRosa and R. K. Hanson... Mecanica , 17-19 Dec. 1990, Zaragosa, Spain; published in Congress Proceedings. 14. D. F. Davidson, A. Y. Chang, M. D. DiRosa and R. K. Hanson

  6. BRAF Mutation Testing in Cell-Free DNA from the Plasma of Patients with Advanced Cancers Using a Rapid, Automated Molecular Diagnostics System.

    Janku, Filip; Huang, Helen J; Claes, Bart; Falchook, Gerald S; Fu, Siqing; Hong, David; Ramzanali, Nishma M; Nitti, Giovanni; Cabrilo, Goran; Tsimberidou, Apostolia M; Naing, Aung; Piha-Paul, Sarina A; Wheler, Jennifer J; Karp, Daniel D; Holley, Veronica R; Zinner, Ralph G; Subbiah, Vivek; Luthra, Rajyalakshmi; Kopetz, Scott; Overman, Michael J; Kee, Bryan K; Patel, Sapna; Devogelaere, Benoit; Sablon, Erwin; Maertens, Geert; Mills, Gordon B; Kurzrock, Razelle; Meric-Bernstam, Funda


    Cell-free (cf) DNA from plasma offers an easily obtainable material for BRAF mutation analysis for diagnostics and response monitoring. In this study, plasma-derived cfDNA samples from patients with progressing advanced cancers or malignant histiocytosis with known BRAF(V600) status from formalin-fixed paraffin-embedded (FFPE) tumors were tested using a prototype version of the Idylla BRAF Mutation Test, a fully integrated real-time PCR-based test with turnaround time about 90 minutes. Of 160 patients, BRAF(V600) mutations were detected in 62 (39%) archival FFPE tumor samples and 47 (29%) plasma cfDNA samples. The two methods had overall agreement in 141 patients [88%; κ, 0.74; SE, 0.06; 95% confidence interval (CI), 0.63-0.85]. Idylla had a sensitivity of 73% (95% CI, 0.60-0.83) and specificity of 98% (95% CI, 0.93-1.00). A higher percentage, but not concentration, of BRAF(V600) cfDNA in the wild-type background (>2% vs. ≤ 2%) was associated with shorter overall survival (OS; P = 0.005) and in patients with BRAF mutations in the tissue, who were receiving BRAF/MEK inhibitors, shorter time to treatment failure (TTF; P = 0.001). Longitudinal monitoring demonstrated that decreasing levels of BRAF(V600) cfDNA were associated with longer TTF (P = 0.045). In conclusion, testing for BRAF(V600) mutations in plasma cfDNA using the Idylla BRAF Mutation Test has acceptable concordance with standard testing of tumor tissue. A higher percentage of mutant BRAF(V600) in cfDNA corresponded with shorter OS and in patients receiving BRAF/MEK inhibitors also with shorter TTF. Mol Cancer Ther; 15(6); 1397-404. ©2016 AACR.

  7. 真菌毒素快速检测技术研究进展%Methodological advances for rapid detection of mycotoxins

    刘娜; 武爱波


    -time, low-cost and large-scale analyses. In this article, state-of-the-art methodo-logical advances for rapid detection of mycotoxins as target analytes in recent 3 years have been summarized, supporting as valuable reference for highly efficient monitoring of mycotoxin contamination in the whole framework of food safety issues.


    César San Martín


    Full Text Available In this work, an effective methodology to detect early stage faults in rotating machinery is proposed. The methodology is based on the analysis of cyclostationarity, which is inherent to the vibration signals generated by rotating machines. Of a particularly interest are the second and higher orders cyclostationary components since they contain valuable information, which can be used for the early detection of faults in rolling bearings and gear systems. The first step of the methodology consists in the separation of the first-order periodicity components from the raw signal, in order to focus the analysis in the residual part of the signal, which contains the second and higher order periodicities. Then, the residual signal is filtered and demodulated, using the frequency range of highest importance. Finally, the demodulated residual signal is auto-correlated, obtaining an enhanced signal that may contain clear spectral components related to the presence of a prospective localized fault. The methodology is validated analyzing experimental vibration data for two different cases. The first case is related to the detection of a crack in one of the teeth of a gearbox system and the second case is related to the detection of a pitfall in the inner race of a rolling bearing. The results show that the proposed method for the condition monitoring of rotating machines is a useful tool for the tasks of fault diagnosis, which can complement the analysis made using traditional diagnostic techniques.En este trabajo se presenta una metodología para detectar fallas incipientes en máquinas rotatorias. La metodología está basada en el análisis de cicloestacionariedad, la cual está presente en las señales de vibración generadas por máquinas rotatorias. De particular interés son las componentes cicloestacionarias de segundo orden y de órdenes superiores, puesto que contienen información relevante, que puede ser usada para detección temprana de fallas

  9. The project ENABLE II randomized controlled trial to improve palliative care for rural patients with advanced cancer: baseline findings, methodological challenges, and solutions.

    Bakitas, Marie; Lyons, Kathleen Doyle; Hegel, Mark T; Balan, Stefan; Barnett, Kathleen N; Brokaw, Frances C; Byock, Ira R; Hull, Jay G; Li, Zhongze; McKinstry, Elizabeth; Seville, Janette L; Ahles, Tim A


    There is a paucity of randomized controlled trials (RCTs) to evaluate models of palliative care. Although interventions vary, all have faced a variety of methodological challenges including adequate recruitment, missing data, and contamination of the control group. We describe the ENABLE II intervention, methods, and sample baseline characteristics to increase intervention and methodological transparency, and to describe our solutions to selected methodological issues. Half of the participants recruited from our rural U.S. comprehensive cancer center and affiliated clinics were randomly assigned to a phone-based, nurse-led educational, care coordination palliative care intervention model. Intervention services were provided to half of the participants weekly for the first month and then monthly until death, including bereavement follow-up call to the caregiver. The other half of the participants were assigned to care as usual. Symptoms, quality of life, mood, and functional status were assessed every 3 months until death. Baseline data of 279 participants were similar to normative samples. Solutions to methodological challenges of recruitment, missing data, and "usual care" control group contamination are described. It is feasible to overcome many of the methodological challenges to conducting a rigorous palliative care RCT.

  10. Flexible intelligence remote diagnostic decision system using fuzzy technology. Advancement of diagnostic decision for computers; Fuzzy gijutsu wo oyoshita remote kosho shindan system. Computer kosho shindan no koseinoka ni tsuite

    Yokota, A.


    AV/Alert system of U.S. Data General Co. (DGC) is a system which performs the remote trouble response to UNIX servers of DGC. As the diagnostic decision has provided low accuracy, highly skilled field engineers have been required. Accordingly, the enhancement of accuracy in the diagnostic decision has been strongly required. For the purpose of drastic improvement in accuracy of the diagnostic decision without experts utilizing fuzzy technology, a flexible intelligence diagnostic decision system (FI-DDS) of AV/Alert has been developed. The FI-remote-DDS is composed of AV/Alert, FI-DDS, and an automatic accumulation software for accident examples. The FI-DDS has made the diagnostic decision engine of AV/Alert highly accurate. The automatic accumulation software for accident examples provides accident examples and statistic data of accident examples required by FI-DDS, automatically. The system was found to be extremely useful from the analytic results of error code and factors using about 400 actual accident example data in the past. 4 figs.

  11. Cognitive Diagnostic Assessment via Bayesian Evaluation of Informative Diagnostic Hypotheses

    Hoitink, Herbert; Beland, Sebastien; Vermeulen, Jorine A.


    There exist diverse approaches that can be used for cognitive diagnostic assessment, such as mastery testing, constrained latent class analysis, rule space methodology, diagnostic cognitive modeling, and person-fit analysis. Each of these approaches can be used within 1 of the 4 psychometric perspec

  12. Cognitive diagnostic assessment via Bayesian evaluation of informative diagnostic hypotheses.

    Hoijtink, Herbert; Béland, Sébastien; Vermeulen, Jorine A.


    There exist diverse approaches that can be used for cognitive diagnostic assessment, such as mastery testing, constrained latent class analysis, rule space methodology, diagnostic cognitive modeling, and person-fit analysis. Each of these approaches can be used within 1 of the 4 psychometric perspec

  13. AMOVA ["Accumulative Manifold Validation Analysis"]: An Advanced Statistical Methodology Designed to Measure and Test the Validity, Reliability, and Overall Efficacy of Inquiry-Based Psychometric Instruments

    Osler, James Edward, II


    This monograph provides an epistemological rational for the Accumulative Manifold Validation Analysis [also referred by the acronym "AMOVA"] statistical methodology designed to test psychometric instruments. This form of inquiry is a form of mathematical optimization in the discipline of linear stochastic modelling. AMOVA is an in-depth…

  14. Rotorcraft Diagnostics

    Haste, Deepak; Azam, Mohammad; Ghoshal, Sudipto; Monte, James


    Health management (HM) in any engineering systems requires adequate understanding about the system s functioning; a sufficient amount of monitored data; the capability to extract, analyze, and collate information; and the capability to combine understanding and information for HM-related estimation and decision-making. Rotorcraft systems are, in general, highly complex. Obtaining adequate understanding about functioning of such systems is quite difficult, because of the proprietary (restricted access) nature of their designs and dynamic models. Development of an EIM (exact inverse map) solution for rotorcraft requires a process that can overcome the abovementioned difficulties and maximally utilize monitored information for HM facilitation via employing advanced analytic techniques. The goal was to develop a versatile HM solution for rotorcraft for facilitation of the Condition Based Maintenance Plus (CBM+) capabilities. The effort was geared towards developing analytic and reasoning techniques, and proving the ability to embed the required capabilities on a rotorcraft platform, paving the way for implementing the solution on an aircraft-level system for consolidation and reporting. The solution for rotorcraft can he used offboard or embedded directly onto a rotorcraft system. The envisioned solution utilizes available monitored and archived data for real-time fault detection and identification, failure precursor identification, and offline fault detection and diagnostics, health condition forecasting, optimal guided troubleshooting, and maintenance decision support. A variant of the onboard version is a self-contained hardware and software (HW+SW) package that can be embedded on rotorcraft systems. The HM solution comprises components that gather/ingest data and information, perform information/feature extraction, analyze information in conjunction with the dependency/diagnostic model of the target system, facilitate optimal guided troubleshooting, and offer

  15. Definition of an object oriented library for the dynamic simulation of advanced energy systems: methodologies, tools and application to combined ICE-ORC power plants

    Vaja, Iacopo


    The present Thesis covers part of the work that has been carried out during the three year Ph.D. course in Industrial Engineering at the University of Parma. Scope of the work is developing theoretical methodologies and a full library of dynamic models that can represent the components that usually appear in energy conversion systems. The proposed library should endorse the possibility to create any desire arrangement of the studied systems, to overcome the lack of testing facilities in or...

  16. Advance of the National Program of Radiological Protection and Safety for medical diagnostic with X-rays; Avance del Programa Nacional de Proteccion y Seguridad Radiologica para diagnostico medico con rayos X

    Verdejo S, M. [Direccion de Riesgos Radiologicos, Direccion General de Salud Ambiental (Mexico)


    The National Program of Radiological Protection and Safety for medical diagnostic with X-ray (Programa Nacional de Proteccion y Seguridad Radiologica para diagnostico medico con rayos X) was initiated in the General Direction of Environmental Health (Direccion General de Salud Ambiental) in 1995. Task coordinated with different dependences of the Public Sector in collaboration between the Secretary of Health (Secretaria de Salud), the National Commission of Nuclear Safety and Safeguards (Comision Nacional de Seguridad Nuclear y Salvaguardias) and, the National Institute of Nuclear Research (Instituto Nacional de Investigaciones Nucleares). The surveillance to the fulfilment of the standardization in matter of Radiological Protection and Safety in the medical diagnostic with X-rays has been obtained for an important advance in the Public sector and it has been arousing interest in the Private sector. (Author)

  17. Acute pulmonary embolism: impact of selection bias in prospective diagnostic studies. ANTELOPE Study Group. Advances in New Technologies Evaluating the Localization of Pulmonary Embolism.

    Hartmann, I J; Prins, M H; Büller, H R; Banga, J D


    We evaluated selection bias in a prospective study of 1,162 consecutive patients with suspected pulmonary embolism. Of these, 983 were eligible, and 627 could actually be included. During two months extensive data were collected on all non-included patients. Finally, our patient characteristics were compared with those of the PIOPED study (1990) and the study of Hull et al. (1994). Compared with included patients, the non-included patients had more often non-diagnostic V/Q scans (50% vs. 36%, p PIOPED study. In the PIOPED study patients who had contra-indications for pulmonary angiography were excluded, while in the study of Hull et al. those with inadequate cardiorespiratory reserve were excluded. In studies on new diagnostic technologies, patient selection bias does occur. The potential for such a selection bias should be taken into account when diagnostic strategies are devised to improve their generalizability and acceptability.

  18. Advancing the education in molecular diagnostics: the IFCC-Initiative "Clinical Molecular Biology Curriculum" (C-CMBC); a ten-year experience.

    Lianidou, Evi; Ahmad-Nejad, Parviz; Ferreira-Gonzalez, Andrea; Izuhara, Kenji; Cremonesi, Laura; Schroeder, Maria-Eugenia; Richter, Karin; Ferrari, Maurizio; Neumaier, Michael


    Molecular techniques are becoming commonplace in the diagnostic laboratory. Their applications influence all major phases of laboratory medicine including predisposition/genetic risk, primary diagnosis, therapy stratification and prognosis. Readily available laboratory hardware and wetware (i.e. consumables and reagents) foster rapid dissemination to countries that are just establishing molecular testing programs. Appropriate skill levels extending beyond the technical procedure are required for analytical and diagnostic proficiency that is mandatory in molecular genetic testing. An international committee (C-CMBC) of the International Federation for Clinical Chemistry (IFCC) was established to disseminate skills in molecular genetic testing in member countries embarking on the respective techniques. We report the ten-year experience with different teaching and workshop formats for beginners in molecular diagnostics.

  19. Tourism Methodologies

    This volume offers methodological discussions within the multidisciplinary field of tourism and shows how tourism researchers develop and apply new tourism methodologies. The book is presented as an anthology, giving voice to many diverse researchers who reflect on tourism methodology in different...... in interview and field work situations, and how do we engage with the performative aspects of tourism as a field of study? The book acknowledges that research is also performance and that it constitutes an aspect of intervention in the situations and contexts it is trying to explore. This is an issue dealt...

  20. Recent advances in the development of capillary electrophoresis methodologies for optimizing, controlling, and characterizing the synthesis, functionalization, and physicochemical, properties of nanoparticles.

    Trapiella-Alfonso, Laura; d'Orlyé, Fanny; Varenne, Anne


    This paper gives a critical overview of capillary electrophoresis (CE) methodologies recently developed for controlling and optimizing the synthesis of nanoparticles as well as characterizing their functionalization in terms of physicochemical properties. Thanks to their electrophoretic mobility, various parameters can be determined, such as NP size and charge distribution, ζ-potential, surface functionality, colloidal stability, grafting rates, and dissociation constants, allowing not only the complete characterization of new nanoprobes but also helping in their design and in the selection of chemical conditions for their storage and further manipulation. New strategies for the improvement of CE detection sensitivity are also described.

  1. Advanced power analysis methodology targeted to the optimization of a digital pixel readout chip design and its critical serial powering system

    Marconi, S.; Orfanelli, S.; Karagounis, M.; Hemperek, T.; Christiansen, J.; Placidi, P.


    A dedicated power analysis methodology, based on modern digital design tools and integrated with the VEPIX53 simulation framework developed within RD53 collaboration, is being used to guide vital choices for the design and optimization of the next generation ATLAS and CMS pixel chips and their critical serial powering circuit (shunt-LDO). Power consumption is studied at different stages of the design flow under different operating conditions. Significant effort is put into extensive investigations of dynamic power variations in relation with the decoupling seen by the powering network. Shunt-LDO simulations are also reported to prove the reliability at the system level.

  2. A modified eco-efficiency framework and methodology for advancing the state of practice of sustainability analysis as applied to green infrastructure.

    Ghimire, Santosh R; Johnston, John M


    We propose a modified eco-efficiency (EE) framework and novel sustainability analysis methodology for green infrastructure (GI) practices used in water resource management. Green infrastructure practices such as rainwater harvesting (RWH), rain gardens, porous pavements, and green roofs are emerging as viable strategies for climate change adaptation. The modified framework includes 4 economic, 11 environmental, and 3 social indicators. Using 6 indicators from the framework, at least 1 from each dimension of sustainability, we demonstrate the methodology to analyze RWH designs. We use life cycle assessment and life cycle cost assessment to calculate the sustainability indicators of 20 design configurations as Decision Management Objectives (DMOs). Five DMOs emerged as relatively more sustainable along the EE analysis Tradeoff Line, and we used Data Envelopment Analysis (DEA), a widely applied statistical approach, to quantify the modified EE measures as DMO sustainability scores. We also addressed the subjectivity and sensitivity analysis requirements of sustainability analysis, and we evaluated the performance of 10 weighting schemes that included classical DEA, equal weights, National Institute of Standards and Technology's stakeholder panel, Eco-Indicator 99, Sustainable Society Foundation's Sustainable Society Index, and 5 derived schemes. We improved upon classical DEA by applying the weighting schemes to identify sustainability scores that ranged from 0.18 to 1.0, avoiding the nonuniqueness problem and revealing the least to most sustainable DMOs. Our methodology provides a more comprehensive view of water resource management and is generally applicable to GI and industrial, environmental, and engineered systems to explore the sustainability space of alternative design configurations. Integr Environ Assess Manag 2017;13:821-831. Published 2017. This article is a US Government work and is in the public domain in the USA. Integrated Environmental Assessment and

  3. Avanços metodológicos na produção in vitro de embriões Methodological advances on in vitro embryo production

    Rodolfo Rumpf


    Full Text Available O desenvolvimento da metodologia de produção in vitro de embriões (PIV para maximizar o ganho genético e a produção animal a um custo baixo é um desafio de pesquisa científica há vários anos. A possibilidade de produzir, em escala comercial, embriões a partir de oócitos puncionados dos folículos ovarianos pode aumentar os benefícios do uso da inseminação artificial devido ao seu decisivo papel no aumento do progresso genético entre gerações de acordo com as necessidades de cada programa de melhoramento genético ou produção animal. Diferentes rotas tecnológicas foram desenvolvidas a partir da PIV em espécies de interesse zootécnico ou espécies ameaçadas de extinção.The development of in vitro embryo production (IVP methodology to maximize genetic gain and animal production at lower cost is a challenge of the research and it has been studied for many years. The possibility to produce, in commercial scale, embryos from ovum pick up methodology may increase the benefits of the use of artificial insemination (AI for its decisive role to maximize the genetic progress between generations, according to the requirements of each genetic improvement program and livestock capacity. Different technological routes are associated to IVP, both for zootechnical interest species and for endangered species.

  4. Novel biosensing methodologies for ultrasensitive detection of viruses.

    Cheng, Ming Soon; Toh, Chee-Seng


    Various infectious diseases caused by the spread of viruses create adverse implications on global biosecurity. Increasing demands for virus surveillance and effective control of the spread of diseases reveal the need for rapid and sensitive virus diagnostic devices. Due to the remarkable sensitivity and specificity of biosensors, they appear as a potential and promising tool for accurate and quantitative detection of viruses. Furthermore, recent advancements in transduction systems, nanotechnology and genetic engineering offer various strategies to improve the detection performance of biosensors. This review presents an overview of the current states of novel biosensing methodologies for the ultrasensitive detection of viruses with highly promising applications for future disease diagnosis. Additionally, a brief summary of the recent state-of-the-art virus diagnostic molecular technologies is included.

  5. 诊断试验偏倚来源的研究进展%Advances in Research on Bias Sources in Diagnostic Test



    诊断是医疗过程中非常重要的一环,诊断试验研究可为临床决策提供重要依据,但诊断试验研究的方案设计、实施和报告中容易出现各种偏倚,充分认识各种偏倚的来源有助于诊断试验的合理实施和评价,以期给临床实践提供科学证据.%Diagnosis is the critical component of health care and the studies of diagnostic test can provide important evidence for clinical decisions.Studies of diagnostic test are subject to different sources of bias in design, performance and reporting of studies.Therefore, researchers who understand various sources of bias can reasonably perform the diagnostic test and evaluate its quality, and will provide scientific evidences for clinical practice.

  6. Methodological issues of postoperative cognitive dysfunction research

    Funder, Kamilia S; Steinmetz, Jacob; Rasmussen, Lars S


    to reveal postoperative cognitive decline, and questionnaires are not useful for this purpose. There is a profound lack of consensus regarding the research methodology for detection of cognitive deterioration, especially the diagnostic criteria. Issues, such as baseline performance, learning effects...

  7. On methodology

    Cheesman, Robin; Faraone, Roque


    This is an English version of the methodology chapter in the authors' book "El caso Berríos: Estudio sobre información errónea, desinformación y manipulación de la opinión pública".......This is an English version of the methodology chapter in the authors' book "El caso Berríos: Estudio sobre información errónea, desinformación y manipulación de la opinión pública"....

  8. Advancing the Direction of Health Information Management in Greek Public Hospitals: Theoretical Directions and Methodological Implications for Sharing Information in order to Obtain Decision-Making

    Evagelia Lappa


    Full Text Available Although consultants have long placed the use of research information at the centre of their activity, the extent that physicians use this information tends to vary widely. Despite this study and its recommendations, there is still a gap between the functions of a manager and the use of the associated information, while the decision-making procedures vary according to the organization in which they work. The cost of IT remains the largest barrier, while some current IT solutions are not user friendly and out-of-date, particularly for public hospitals in Greece. The knowledge management is concerned not only with the facts and figures of production, but also with the know-how of staff. The information needs protocol should not be referred only to those who comply with formal computer-based information systems, but also to those who take into account other informal information and its flow within the organization. In a field such as medicine, where out-of-date information may be positively dangerous, doctors make heavy use of journals and several texts from the web. The decision-making process is a complex approach, particularly in human diagnostic and therapeutic applications. Therefore, it is very important to set priorities in the sector of health information management and promote education and training on information and communication technology (ICT.

  9. The help of Advanced Satellite Interferometry in assessing the effect of human-induced surface deformation in naturally subsiding areas. Methodological approach and applications

    Tamburini, Andrea; Giannico, Chiara; Del Conte, Sara; Teatini, Pietro


    Underground water extraction, natural gas storage either in depleted hydrocarbon reservoirs or in aquifers, and excavations for civil works (e.g. underground passageways, car parks, etc.) in flat areas are responsible for surface deformation that can damage pre-existing structures and modify drainage pathways. Deformation patterns associated to different underground show in many cases typical patterns. Their recognition can help in disentangling different processes when occurring in areas already affected by natural subsidence, such as coastal areas and inner sedimentary plains. Moreover, assessing the extent of human-induced deformation can help in identifying causes, modelling phenomena, predicting their evolution and adopting proper remedial measures. Advanced Satellite Interferometry provides a synoptic view of surface displacements over large areas and long time-spans and has become a standard in several Italian regions where underground fluid injection and withdrawal is going on. The integration of interferometric measurements with ground (leveling, GPS) and underground (borehole extensometers, piezometers, micro-seismic) monitoring networks can provide an exhaustive framework of the effect induced at surface level by underground human activities at local and regional scale. Documented case studies demonstrating the effectiveness of the above approach will be presented.

  10. Summary Describing Integration of ERM Methodology into Supervisory Control Framework with Software Package Documentation; Advanced Reactor Technology Milestone: M4AT-16PN2301052

    Ramuhalli, Pradeep [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hirt, Evelyn H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dib, Gerges [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Veeramany, Arun [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bonebrake, Christopher A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Roy, Surajit [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)


    This project involved the development of enhanced risk monitors (ERMs) for active components in Advanced Reactor (AdvRx) designs by integrating real-time information about equipment condition with risk monitors. Health monitoring techniques in combination with predictive estimates of component failure based on condition and risk monitors can serve to indicate the risk posed by continued operation in the presence of detected degradation. This combination of predictive health monitoring based on equipment condition assessment and risk monitors can also enable optimization of maintenance scheduling with respect to the economics of plant operation. This report summarizes PNNL’s multi-year project on the development and evaluation of an ERM concept for active components while highlighting FY2016 accomplishments. Specifically, this report provides a status summary of the integration and demonstration of the prototypic ERM framework with the plant supervisory control algorithms being developed at Oak Ridge National Laboratory (ORNL), and describes additional case studies conducted to assess sensitivity of the technology to different quantities. Supporting documentation on the software package to be provided to ONRL is incorporated in this report.

  11. Molecular diagnostics of myeloproliferative neoplasms

    Langabeer, S. E.; Andrikovics, H.; Asp, J.;


    identified. These discoveries have been rapidly incorporated into evolving molecular diagnostic algorithms. Whilst many of these mutations appear to have prognostic implications, establishing MPN diagnosis is of immediate clinical importance with selection, implementation and the continual evaluation...... of the appropriate laboratory methodology to achieve this diagnosis similarly vital. The advantages and limitations of these approaches in identifying and quantitating the common MPN-associated mutations are considered herein with particular regard to their clinical utility. The evolution of molecular diagnostic...

  12. Methodological guidelines

    Halsnaes, K.; Callaway, J.M.; Meyer, H.J.


    The guideline document establishes a general overview of the main components of climate change mitigation assessment. This includes an outline of key economic concepts, scenario structure, common assumptions, modelling tools and country study assumptions. The guidelines are supported by Handbook Reports that contain more detailed specifications of calculation standards, input assumptions and available tools. The major objectives of the project have been provided a methodology, an implementing framework and a reporting system which countries can follow in meeting their future reporting obligations under the FCCC and for GEF enabling activities. The project builds upon the methodology development and application in the UNEP National Abatement Coasting Studies (UNEP, 1994a). The various elements provide countries with a road map for conducting climate change mitigation studies and submitting national reports as required by the FCCC. (au) 121 refs.

  13. Development of Methodologies for Technology Deployment for Advanced Outage Control Centers that Improve Outage Coordination, Problem Resolution and Outage Risk Management

    Shawn St. Germain; Ronald Farris; Heather Medeman


    schedule depends upon the performance of the outage management organization. During an outage, the outage control center (OCC) is the temporary command center for outage managers and provides several critical functions for the successful execution of the outage schedule. Essentially, the OCC functions to facilitate information inflow, assist outage management in processing information and to facilitate the dissemination of information to stakeholders. Currently, outage management activities primarily rely on telephone communication, face to face reports of status and periodic briefings in the OCC. Much of the information displayed in OCCs is static and out of date requiring an evaluation to determine if it is still valid. Several advanced communication and collaboration technologies have shown promise for facilitating the information flow into, across and out of the OCC. Additionally, advances in the areas of mobile worker technologies, computer based procedures and electronic work packages can be leveraged to improve the availability of real time status to outage managers.

  14. Avanços metodológicos da microscopia na avaliação de alimentos Methodological advances of microscopy in food-stuff evaluation

    Beatriz Lempp


    , as well as the development of samples preparation techniques, provided excellent tools in the several science areas. The evaluations at the microscope, electron or optical, of edible products utilized for ruminants, has helped in the cause/effect relationship understanding in animal performance. Of paramount importance are the advances obtained in the action mode of rumen microorganisms in the substrates knowledge, mainly of the particle-associated bacteria. Advances were also achieved in the knowledge of factors that affect the forage dry matter degradability, especially of the C3 species, but these advances also contribute to the knowledge of the C4. These studies results allowed the establishment of several research lines, creating the possibility of discrimination in the early stages of grasses and legumes selection, those which present the greatest qualitative potential. There is especial merit also in the studies to increase the corn and alfalfa stalk degradability, as well as those to identify how the agricultural byproducts treatment can increase its quality, and to verify the effect of inoculants, such as exogenous enzymes, in the dry matter degradability rate. Besides the verification of the tannin effect, especially in legumes, into the digestibility, which may in the future to foster the utilization of additives that can minimize or prevent their harmful effects on forage consumption. With relation to cereal grains, it may be verified the genotype influence on degradability. The results achieved up to now, give the base for the genetic manipulation of feed stuff utilized by ruminants, which probably will be object of research in the next decades.

  15. Advance in Methodology Development for Detecting Vibrio parahaemolyticus%副溶血弧菌检测方法研究进展

    温灿; 顾小松; 王荣智


    Vibrio parahaemolyticus (Vp) is a halophilic gram‐negative bacterium .It widely exists in warm water fishes ,shrimps and shellfishes .The seafood carriers ,when ingested ,can cause the typical gastroenteritis symptoms including diarrhea ,intestinal cramps ,nausea and vomiting .When a patient is seriously infected ,septicemia and kidney failure may result .The rate of the food poisoning incidents caused by V p has increased drastically in recent years ,reaching the top of the list among all foodborne illnesses .With the wide‐spread nature and seriousness of the diseases in humans ,the need for a rapid ,sensitive ,low‐cost and effective detection method has become apparent . Methodologies based on the virulence factors that apply the molecular biology techniques including PCR ,Loop‐mediated isothermal amplification ,nucleic acid probe and gene chip ,as well as the immunology tools ,such as ELISA and the immune colloidal gold ,are being explored .This article evaluates the relevant methods to provide a comprehensive reference for the related studies .%副溶血弧菌是一种嗜盐的革兰氏阴性菌,它广泛分布于温暖海域的海产品中,如鱼、虾、贝类等,食用被其感染的海鲜可导致食用者出现腹泻、肠痉挛、恶心、呕吐等典型胃肠炎症状,严重时可引起败血症,肾功能衰竭等临床反应。近年来,由副溶血弧菌引发的食物中毒事件的发生比例呈猛烈的上升趋势,并且领先于其他食源性致病菌,居于首位。鉴于其污染范围广,致病力强,对副溶血弧菌实现快速、灵敏、经济、有效的检测是减少其污染海洋产品,保障人体健康的关键,也是当代研究的热门。目前,基于其毒力致病机理的检测方法得到了很大的发展,主要包括分子生物学范畴的PCR法、环介导等温扩增技术、核酸探针技术、基因芯片技术等与免疫学范畴的ELISA ,胶体金技术等。本文综述了

  16. Development and Application of a Novel Rasch-Based Methodology for Evaluating Multi-Tiered Assessment Instruments: Validation and Utilization of an Undergraduate Diagnostic Test of the Water Cycle

    Romine, William L.; Schaffer, Dane L.; Barrow, Lloyd


    We describe the development and validation of a three-tiered diagnostic test of the water cycle (DTWC) and use it to evaluate the impact of prior learning experiences on undergraduates' misconceptions. While most approaches to instrument validation take a positivist perspective using singular criteria such as reliability and fit with a measurement…

  17. Diagnostic Testing and the Development of CAL Remedial Sequences.

    Ferraris, M.; And Others


    Presents methodology for designing and delivering computer-assisted diagnostic tests and discusses two natural applications of this methodology: for testing purposes, and for implementing adaptive computer-assisted learning sequences based on test results. (MBR)

  18. Multifractal methodology

    Salat, Hadrien; Arcaute, Elsa


    Various methods have been developed independently to study the multifractality of measures in many different contexts. Although they all convey the same intuitive idea of giving a "dimension" to sets where a quantity scales similarly within a space, they are not necessarily equivalent on a more rigorous level. This review article aims at unifying the multifractal methodology by presenting the multifractal theoretical framework and principal practical methods, namely the moment method, the histogram method, multifractal detrended fluctuation analysis (MDFA) and modulus maxima wavelet transform (MMWT), with a comparative and interpretative eye.

  19. Recent advances of diagnostic approaches in primary ciliary dyskinesia%原发性纤毛不动综合征诊断方法研究进展

    刘娇(综述); 刘恩梅; 邓昱(审校)


    Primary ciliary dyskinesia (PCD) is an autosomal recessive or x-linked disorder of cilia structure and (or) function, with a morbidity of 1:10 000–1:50 000 from foreign reports, while epidemic data of PCD in China is not available yet. PCD is due to cilia biallelic gene mutations leading to impaired tissue structure and organ function. Clinical phenotypes include chronic infections of the respiratory tract, fertility problems, disorders of organ laterality, etc, and the percent age of Kartagener syndrome is about 50%. The frequently used diagnostic methods are nasal NO examination, high-speed video microscopy, electron microscopy, genetic tests, chest high-resolution computed tomography and spirometry at present. Each method has its highlights and disadvantages, meanwhile, effective diagnostic algorithm and therapeutic protocols are needed for further research.%原发性纤毛不动综合征是一种常染色体隐性遗传或X染色体相关的遗传疾病,国外发病率为1∶50000~1∶10000,国内尚无相关流行病学资料。该病发生机制为纤毛的双等位基因突变,导致组织器官的结构和/或功能改变,从而引起一系列相关临床表现,其中约50%为Kartagener综合征。目前常用的检查方法有鼻呼出气一氧化氮检测、透射电镜法、免疫荧光分析法、高频数字视频成像和基因诊断,但每种检查方法均有其优点及弊端。同时,统一的诊断思路及确切有效的治疗方案也处于探索研究阶段。

  20. Pitfalls in diagnostic radiology

    Peh, Wilfred C.G. (ed.) [Khoo Teck Puat Hospital (Singapore). Dept. of Diagnostic Radiology


    Only textbook to focus primarily on the topic of pitfalls in diagnostic radiology. Highlights the pitfalls in a comprehensive and systematic manner. Written by experts in different imaging modalities and subspecialties from reputable centers across the world. The practice of diagnostic radiology has become increasingly complex, with the use of numerous imaging modalities and division into many subspecialty areas. It is becoming ever more difficult for subspecialist radiologists, general radiologists, and residents to keep up with the advances that are occurring year on year, and this is particularly true for less familiar topics. Failure to appreciate imaging pitfalls often leads to diagnostic error and misinterpretation, and potential medicolegal problems. Diagnostic errors may be due to various factors such as inadequate imaging technique, imaging artifacts, failure to recognize normal structures or variants, lack of correlation with clinical and other imaging findings, and poor training or inexperience. Many, if not most, of these factors are potentially recognizable, preventable, or correctable. This textbook, written by experts from reputable centers across the world, systematically and comprehensively highlights the pitfalls that may occur in diagnostic radiology. Both pitfalls specific to different modalities and techniques and those specific to particular organ systems are described with the help of numerous high-quality illustrations. Recognition of these pitfalls is crucial in helping the practicing radiologist to achieve a more accurate diagnosis.

  1. Advances in the processing of policromat images as diagnostic method to determine white spot syndrome virus in white shrimp (Litopenaeus vannamei)

    Chavez-Sanchez, Cristina M.; Alvarez-Borrego, Josue; Montoya-Rodriguez, L.; Garcia-Gasca, A.; Fajer Avila, Emma J.; Pacheco-Marges, R.


    White spot syndrome (WSSV) is a viral disease which affects many crustacean species including commercial shrimps. Adequate, precise and quick methods to diagnose on time the presence of the disease in order to apply different strategies to avoid the dispersion and to reduce mortalities is necessary. Histopathology is an important diagnostic method. However, histopathology has the problem that requires time to prepare the histological slides and time to arrive to some diagnosis because this depend on the nature of the tissues, the pathogen(s) to find, the number of organisms, number of slides to analyze and the skill of the technician. This paper try to demonstrate the sensibility of one digital system of processing and recognition of images using color correlation with phase filters, to identify inclusion bodies of WSSV. Infected tissues were processed to obtain histological slides and to verify that the inclusion bodies observed were of WSV, in situ hybridization were carried out. The sensibility results of the recognition of the inclusion bodies of WSSV with the color correlation program was 86.1%. The highest percentage of recognition was in nervous system and tegument glands with 100%. The values in the stomach epithelium and heart tissue was 78.45% of recognition. Tissues with the lowest recognition values were lymphoid organ and hematopoietic tissue. It is necessary further studies to increase the sensibility and to obtain the specificity.

  2. 78 FR 28864 - Prospective Grant of Start-Up Exclusive Evaluation Option License Agreement: In Vitro Diagnostics...


    ... License Agreement: In Vitro Diagnostics for Prediction of Therapeutic Efficacy in Cancer and Other... Exclusive Evaluation Option License Agreement to Advanced Personalized Diagnostics, LLC, a company having a... Option License Agreement, Advanced Personalized Diagnostics, LLC will have ] the exclusive right...

  3. Acoustic emission methodology and application

    Nazarchuk, Zinoviy; Serhiyenko, Oleh


    This monograph analyses in detail the physical aspects of the elastic waves radiation during deformation or fracture of materials. I presents the  methodological bases for the practical use of acoustic emission device, and describes the results of theoretical and experimental researches of evaluation of the crack growth resistance of materials, selection of the useful AE signals. The efficiency of this methodology is shown through the diagnostics of various-purpose industrial objects. The authors obtain results of experimental researches with the help of the new methods and facilities.

  4. Bayesian wavelet PCA methodology for turbomachinery damage diagnosis under uncertainty

    Xu, Shengli; Jiang, Xiaomo; Huang, Jinzhi; Yang, Shuhua; Wang, Xiaofang


    Centrifugal compressor often suffers various defects such as impeller cracking, resulting in forced outage of the total plant. Damage diagnostics and condition monitoring of such a turbomachinery system has become an increasingly important and powerful tool to prevent potential failure in components and reduce unplanned forced outage and further maintenance costs, while improving reliability, availability and maintainability of a turbomachinery system. This paper presents a probabilistic signal processing methodology for damage diagnostics using multiple time history data collected from different locations of a turbomachine, considering data uncertainty and multivariate correlation. The proposed methodology is based on the integration of three advanced state-of-the-art data mining techniques: discrete wavelet packet transform, Bayesian hypothesis testing, and probabilistic principal component analysis. The multiresolution wavelet analysis approach is employed to decompose a time series signal into different levels of wavelet coefficients. These coefficients represent multiple time-frequency resolutions of a signal. Bayesian hypothesis testing is then applied to each level of wavelet coefficient to remove possible imperfections. The ratio of posterior odds Bayesian approach provides a direct means to assess whether there is imperfection in the decomposed coefficients, thus avoiding over-denoising. Power spectral density estimated by the Welch method is utilized to evaluate the effectiveness of Bayesian wavelet cleansing method. Furthermore, the probabilistic principal component analysis approach is developed to reduce dimensionality of multiple time series and to address multivariate correlation and data uncertainty for damage diagnostics. The proposed methodology and generalized framework is demonstrated with a set of sensor data collected from a real-world centrifugal compressor with impeller cracks, through both time series and contour analyses of vibration

  5. Comparison of automated and manual determination of HER2 status in breast cancer for diagnostic use: a comparative methodological study using the Ventana BenchMark automated staining system and manual tests.

    Bánkfalvi, Agnes; Boecker, Werner; Reiner, Angelika


    This study was performed to test the validity of manual and automated HER2 tests in one hundred routinely formalin-fixed and paraffin-embedded diagnostic breast carcinoma tissues. Immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) assays for HER2 were separately carried out in two institutes of pathology specialised in diagnostics of breast diseases. Manual immunostaining was performed by the Dako-HercepTest. Automated IHC and FISH were carried out in the Ventana BenchMark platform by using the Pathway-CB11 antibody and the INFORM(R) HER2 probe, respectively. Positivity rates varied between HercepTest (26%), automated CB11 IHC (23%) and automated FISH (22%). Overall concordance between positive (2+, 3+) and negative (0; 1+) results of manual and automated IHC was 97%, between automated FISH and IHC 92%, and between automated FISH and HercepTest 89%. The frequency of 2+ IHC scores was 13% using the BenchMark and 14% with the HercepTest; 6/12 and 8/14 of the respective cases were not amplified by FISH. Automated FISH was not interpretable in 11 of 100 specimens. In the 89 informative cases, automated IHC resulted in increased specificity (92% vs. 88%), increased positive predictive value (73% vs. 64%) and increased efficiency (92% vs. 89%). We conclude that automation improves the accuracy of HER2 detection in diagnostic breast carcinoma tissues and provides a new approach for the global standardization of clinical HER2 tests.

  6. Research Methodology

    Rajasekar, S; Philomination, P


    In this manuscript various components of research are listed and briefly discussed. The topics considered in this write-up cover a part of the research methodology paper of Master of Philosophy (M.Phil.) course and Doctor of Philosophy (Ph.D.) course. The manuscript is intended for students and research scholars of science subjects such as mathematics, physics, chemistry, statistics, biology and computer science. Various stages of research are discussed in detail. Special care has been taken to motivate the young researchers to take up challenging problems. Ten assignment works are given. For the benefit of young researchers a short interview with three eminent scientists is included at the end of the manuscript.

  7. Quantitative DCE-MRI for prediction of pathological complete response following neoadjuvant treatment for locally advanced breast cancer: the impact of breast cancer subtypes on the diagnostic accuracy

    Drisis, Stylianos; Stathopoulos, Konstantinos; Chao, Shih-Li; Lemort, Marc [Institute Jules Bordet, Radiology Department, Brussels (Belgium); Metens, Thierry [Erasme University Hospital, Radiology Department, Brussels (Belgium); Ignatiadis, Michael [Institute Jules Bordet, Oncology Department, Brussels (Belgium)


    To assess whether DCE-MRI pharmacokinetic (PK) parameters obtained before and during chemotherapy can predict pathological complete response (pCR) differently for different breast cancer groups. Eighty-four patients who received neoadjuvant chemotherapy for locally advanced breast cancer were retrospectively included. All patients underwent two DCE-MRI examinations, one before (EX1) and one during treatment (EX2). Tumours were classified into different breast cancer groups, namely triple negative (TNBC), HER2+ and ER+/HER2-, and compared with the whole population (WP). PK parameters Ktrans and Ve were extracted using a two-compartment Tofts model. At EX1, Ktrans predicted pCR for WP and TNBC. At EX2, maximum diameter (Dmax) predicted pCR for WP and ER+/HER2-. Both PK parameters predicted pCR in WP and TNBC and only Ktrans for the HER2+. pCR was predicted from relative difference (EX1 - EX2)/EX1 of Dmax and both PK parameters in the WP group and only for Ve in the TNBC group. No PK parameter could predict response for ER+/HER-. ROC comparison between WP and breast cancer groups showed higher but not statistically significant values for TNBC for the prediction of pCR Quantitative DCE-MRI can better predict pCR after neoadjuvant treatment for TNBC but not for the ER+/HER2- group. (orig.)

  8. Diagnostics development plan for ZR.

    Hanson, David Lester


    The Z Refurbishment (ZR) Project is a program to upgrade the Z machine at SNL with modern durable pulsed power technology, providing additional shot capacity and improved reliability as well as advanced capabilities for both pulsed x-ray production and high pressure generation. The development of enhanced diagnostic capabilities is an essential requirement for ZR to meet critical mission needs. This report presents a comprehensive plan for diagnostic instrument and infrastructure development for the first few years of ZR operation. The focus of the plan is on: (1) developing diagnostic instruments with high spatial and temporal resolution, capable of low noise operation and survival in the severe EMP, bremsstrahlung, and blast environments of ZR; and (2) providing diagnostic infrastructure improvements, including reduced diagnostic trigger signal jitter, more and flexible diagnostic line-of-sight access, and the capability for efficient exchange of diagnostics with other laboratories. This diagnostic plan is the first step in an extended process to provide enhanced diagnostic capabilities for ZR to meet the diverse programmatic needs of a broad range of defense, energy, and general science programs of an international user community into the next decade.

  9. Astrovirus Diagnostics

    Pérot, Philippe; Lecuit, Marc; Eloit, Marc


    Various methods exist to detect an astrovirus infection. Current methods include electron microscopy (EM), cell culture, immunoassays, polymerase chain reaction (PCR) and various other molecular approaches that can be applied in the context of diagnostic or in surveillance studies. With the advent of metagenomics, novel human astrovirus (HAstV) strains have been found in immunocompromised individuals in association with central nervous system (CNS) infections. This work reviews the past and current methods for astrovirus detection and their uses in both research laboratories and for medical diagnostic purposes. PMID:28085120

  10. Methodological Advances in Bibliometric Mapping of Science

    N.J.P. van Eck (Nees Jan)


    textabstractBibliometric mapping of science is concerned with quantitative methods for visually representing scientific literature based on bibliographic data. Since the first pioneering efforts in the 1970s, a large number of methods and techniques for bibliometric mapping have been proposed and te

  11. Advanced optical diagnostics applied to a multi-cylinder engine with gasoline direct injection; Weiterentwicklung der Visualisierungsmethodik am Beispiel eines Mehrzylindermotors mit Benzindirekteinspritzung

    Alt, M.; Eberle, F.; Schaffner, P.; Quarg, J. [Opel Powertrain GmbH, Ruesselsheim (Germany)


    The development of modern combustion processes requires a more intensive use of simulation and optical measuring methods. When the combustion method of an engine concept has been determined and subsequently applied to one or more engines, the following development steps usually do not include the optical access. But in this phase of multicylinder engine development, too, an optical evaluation of the combustion processes provides important information. Especially regarding problems of time, the optical data can help to adopt the right solution and check it for its effect more easily. In this way the videoscopy offers a significant tool to optimize today's engines. The techniques of visualizing the Otto engine related combustion are continuously advanced. The resolution of quickacting CCD cameras has been improved considerably while at the same time reducing the exposure time. Both the injection and the mixture preparation can be investigated in detail under realistic conditions. Variations in the mixture preparation from cycle to cycle can also be represented. Today's state-of-the-art cameras with amplifier can visualize the optimum sootfree combustion without the necessity of an additional light. High-speed photomultiplier cameras can record single combustion cycles with a high resolution and thus enable the analysis. The endoscopic consideration of the combustion processes is no longer restricted to the visible range of the wavelength, but constitutes a visualization of the combustion in the ultraviolet range. The example of a four-cylinder engine with gasoline direct injection demonstrates the good applicability of the videoscopy. This technique can be employed quite easily to improve the understanding of the engine processes during the development phase. (orig.)

  12. Gear noise, vibration, and diagnostic studies at NASA Lewis Research Center

    Zakrajsek, J. J.; Oswald, F. B.; Townsend, D. P.; Coy, J. J.


    The NASA Lewis Research Center and the U.S. Army Aviation Systems Command are involved in a joint research program to advance the technology of rotorcraft transmissions. This program consists of analytical as well as experimental efforts to achieve the overall goals of reducing weight, noise, and vibration, while increasing life and reliability. Recent analytical activities are highlighted in the areas of gear noise, vibration, and diagnostics performed in-house and through NASA and U.S. Army sponsored grants and contracts. These activities include studies of gear tooth profiles to reduce transmission error and vibration as well as gear housing and rotordynamic modeling to reduce structural vibration and transmission and noise radiation, and basic research into current gear failure diagnostic methodologies. Results of these activities are presented along with an overview of near-term research plans in the gear noise, vibration, and diagnostics area.

  13. MeDITA - A methodology for the characterisation of air handling units - The method and its results; MeDITA - Methode de diagnostic des installations de traitement d'air - La methode et ses resultats

    Roulet, C.-A.; Pibiri, M.-C. [Swiss Federal Institute of Technology (EPFL), LESO-PB, Lausanne (Switzerland); Foradini, F. [E4Tech, Lausanne (Switzerland)


    A methodology, procedures and instruments were developed to measure as easily as possible the characteristics of air handling units. This method allows assessment of the following characteristics: main air flow rates, recirculation rate, leakage rate, shortcuts, mean age of the air in the ventilated zone and ventilation efficiency, fan power efficiency, and heat recovery efficiency. The measurement of air flow rates is based on the tracer gas dilution method, the tracer gas being injected either at constant rate or in a pulse. A computer program helps in planning and interpreting the measurements. (author)

  14. Technological advances in bovine mastitis diagnosis: an overview.

    Duarte, Carla M; Freitas, Paulo P; Bexiga, Ricardo


    Bovine mastitis is an economic burden for dairy farmers and preventive control measures are crucial for the sustainability of any dairy business. The identification of etiological agents is necessary in controlling the disease, reducing risk of chronic infections and targeting antimicrobial therapy. The suitability of a detection method for routine diagnosis depends on several factors, including specificity, sensitivity, cost, time in producing results, and suitability for large-scale sampling of milk. This article focuses on current methodologies for identification of mastitis pathogens and for detection of inflammation, as well as the advantages and disadvantages of different methods. Emerging technologies, such as transcriptome and proteome analyses and nano- and microfabrication of portable devices, offer promising, sensitive methods for advanced detection of mastitis pathogens and biomarkers of inflammation. The demand for alternative, fast, and reliable diagnostic procedures is rising as farms become bigger. Several examples of technological and scientific advances are summarized which have given rise to more sensitive, reliable and faster diagnostic results.

  15. [Diagnostic approach to infectious endocarditis].

    Parize, Perrine; Mainardi, Jean-Luc


    Major advances in imaging and microbiological procedures have changed the diagnostic approach of infective endocarditis. New imaging tools have improved the search of local complications, systemic embolism and diagnosis of infection of cardiac devices. Moreover, microbiological diagnosis has been transformed by molecular techniques as long as these procedures have highlighted microorganisms thus far neglected by classical techniques. Despite these advances, endocarditis remained a clinical diagnosis which still depends on a high index of clinical suspicion.

  16. Nanobiosensors in diagnostics

    Alejandro Chamorro-Garcia


    Full Text Available Medical diagnosis has been greatly improved thanks to the development of new techniques capable of performing very sensitive detection and quantifying certain parameters. These parameters can be correlated with the presence of specific molecules and their quantity. Unfortunately, these techniques are demanding, expensive, and often complicated. On the other side, progress in other fields of science and technology has contributed to the rapid growth of nanotechnology. Although being an emerging discipline, nanotechnology has raised huge interest and expectations. Most of the enthusiasm comes from new possibilities and properties of nanomaterials. Biosensors (simple, robust, sensitive, cost-effective combined with nanomaterials, also called nanobiosensors, are serving as bridge between advanced detection/diagnostics and daily/routine tests. Here we review some of the latest applications of nanobiosensors in diagnostics field.

  17. Influência da metodologia de avaliação da camada semi-redutora em radiologia diagnóstica The methodology for evaluating half-value layer and its influence on the diagnostic radiology

    Marco Aurélio de Sousa Lacerda


    Full Text Available OBJETIVO: A análise crítica da metodologia de medida da camada semi-redutora em feixes de raios X teve como base o regulamento técnico para proteção radiológica e controle de qualidade em radiodiagnóstico médico e odontológico. MATERIAIS E MÉTODOS: Na medida da camada semi-redutora, a técnica radiográfica, o arranjo experimental, os meios espalhadores, a instrumentação, o tamanho de campo de radiação e a metodologia de análise dos dados foram considerados. RESULTADOS: A camada semi-redutora obtida em condições de boa geometria, para a técnica escolhida, foi de 2,44 ± 0,02 mmAl. Em relação a este valor, observaram-se desvios máximos na camada semi-redutora de 4,1% na variação da geometria, de 98,8% na variação da câmara de ionização e do meio espalhador, e de até 29,5% com outro tipo de detector. CONCLUSÃO: Os resultados mostraram que não ocorre variação significante na camada semi-redutora para diferentes tamanhos de campo de radiação, mas foram evidentes a influência do espalhamento na superestimação da camada semi-redutora e a redução desta na presença de blocos de chumbo como meio espalhador. O procedimento prático adotado mostrou-se bastante confiável e evidenciou a grande discrepância decorrente da adoção de metodologias impróprias, enfatizando a necessidade de estabelecer um procedimento padrão para a medida da camada semi-redutora.OBJECTIVE: The critical analysis of the methodology for evaluating the x-ray beam half-value layer was based on technical standards for radiological protection and quality control in medical and dental diagnoses. MATERIALS AND METHODS: Exposure parameters, experimental set-up, scattering materials, instrumentation, size of radiation field and methodology of data analysis have been taken into consideration for measurements of half-value layer. RESULTS: The half-value layer, in good geometry, measured 2.44 ± 0.02 mmAl. A maximum deviation of 4.1% was found under

  18. Molecular diagnostics of neurodegenerative disorders

    Megha eAgrawal


    Full Text Available Molecular diagnostics provide a powerful method to detect and diagnose various neurological diseases such as Alzheimer’s and Parkinson’s disease. The confirmation of such diagnosis allows early detection and subsequent medical counseling that help specific patients to undergo clinically important drug trials. This provides a medical pathway to have better insight of neurogenesis and eventual cure of the neurodegenerative diseases. In this short review, we present recent advances in molecular diagnostics especially biomarkers and imaging spectroscopy for neurological diseases. We describe advances made in Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis and Huntington’s disease, and finally present a perspective on the future directions to provide a framework for further developments and refinements of molecular diagnostics to combat neurodegenerative disorders.

  19. A Methodology to Assess Diagnostic Competence in Anatomical Pathology Examinations for Pathology Residents Metodología para evaluar la competencia diagnóstico de exámenes anatomopatológicos en residentes de Anatomía Patológica

    Caridad Socorro Castro


    Full Text Available Background: For years, the tools for learning assessment of physicians in specialization programs have had an empirical character, leading to problems in the quality of the process. Very often, these tools do not measure the fulfilment of proposed educational objectives and grades awarded to students do not reflect their practical achievements and professional skills. Objective: To develop a methodology to assess diagnostic competence in anatomical pathology examinations for Pathology residents. Method: Development research conducted in the University Hospital of Cienfuegos between 2008 and 2010. In addition to theoretical and empirical methods, experts’ criteria were applied to validate the proposal. Results: A logical, stages-based design of a general methodology was created. A tool including indicators and standards was conformed to assess skills and knowledge while interns performe key activities of their specialty. The methodology was validated through experts’ criteria. Conclusions: Teachers and tutors of this specialty are now provided with an unprecedented methodological tool. Its usefulness lies in a more objective assessment of knowledge and skills for diagnostic biopsies, cytology and autopsies. This procedures support diagnostic competence in pathological examinations, which is ultimately pathologists’ key role. The present methodological design can be adapted and applied in the evaluation of interns from other specialties.Fundamento: Durante años los instrumentos para la evaluación del aprendizaje de médicos en especialización han tenido un carácter empírico, lo cual ha conllevado a problemas en la calidad del proceso, pues con relativa frecuencia dichos instrumentos no miden el cumplimiento de los objetivos educacionales propuestos y las calificaciones otorgadas no expresan de forma objetiva el aprovechamiento de los

  20. Sensitive Diagnostics for Chemically Reacting Flows

    Farooq, Aamir


    This talk will feature latest diagnostic developments for sensitive detection of gas temperature and important combustion species. Advanced optical strategies, such as intrapulse chirping, wavelength modulation, and cavity ringdown are employed.

  1. New methodologies for patients rehabilitation.

    Fardoun, H M; Mashat, A S; Lange, B


    The present editorial is part of the focus theme of Methods of Information in Medicine titled "New Methodologies for Patients Rehabilitation", with a specific focus on technologies and human factors related to the use of Information and Communication Technologies (ICT) for improving patient rehabilitation. The focus theme explores different dimensions of empowerment methodologies for disabled people in terms of rehabilitation and health care, and to explores the extent to which ICT is a useful tool in this process. The focus theme lists a set of research papers that present different ways of using ICT to develop advanced systems that help disabled people in their rehabilitation process.

  2. The impact of new trends in POCTs for companion diagnostics, non-invasive testing and molecular diagnostics.

    Huckle, David


    Point-of-care diagnostics have been slowly developing over several decades and have taken on a new importance in current healthcare delivery for both diagnostics and development of new drugs. Molecular diagnostics have become a key driver of technology change and opened up new areas in companion diagnostics for use alongside pharmaceuticals and in new clinical approaches such as non-invasive testing. Future areas involving smartphone and other information technology advances, together with new developments in molecular biology, microfluidics and surface chemistry are adding to advances in the market. The focus for point-of-care tests with molecular diagnostic technologies is focused on advancing effective applications.

  3. Development and Application of a Novel Rasch-based Methodology for Evaluating Multi-Tiered Assessment Instruments: Validation and utilization of an undergraduate diagnostic test of the water cycle

    Romine, William L.; Schaffer, Dane L.; Barrow, Lloyd


    We describe the development and validation of a three-tiered diagnostic test of the water cycle (DTWC) and use it to evaluate the impact of prior learning experiences on undergraduates' misconceptions. While most approaches to instrument validation take a positivist perspective using singular criteria such as reliability and fit with a measurement model, we extend this to a multi-tiered approach which supports multiple interpretations. Using a sample of 130 undergraduate students from two colleges, we utilize the Rasch model to place students and items along traditional one-, two-, and three-tiered scales as well as a misconceptions scale. In the three-tiered and misconceptions scales, high confidence was indicative of mastery. In the latter scale, a 'misconception' was defined as mastery of an incorrect concept. We found that integrating confidence into mastery did little to change item functioning; however, three-tiered usage resulted in higher reliability and lower student ability estimates than two-tiered usage. The misconceptions scale showed high efficacy in predicting items on which particular students were likely to express misconceptions, and revealed several tenacious misconceptions that all students were likely to express regardless of ability. Previous coursework on the water cycle did little to change the prevalence of undergraduates' misconceptions.

  4. Research Methodology in Recurrent Pregnancy Loss

    Christiansen, Ole B


    The aim of this article is to highlight pitfalls in research methodology that may explain why studies in recurrent pregnancy loss (RPL) often provide very divergent results. It is hoped that insight into this issue may help clinicians decide which published studies are the most valid. It may help...... researchers to eliminate methodological flaws in future studies, which may hopefully come to some kind of agreement about the usefulness of diagnostic tests and treatments in RPL....

  5. Fractal and Euclidean geometric diagnostic methodology of uterine cervix cells = Metodología diagnóstica geométrica fractal y euclidiana de células del cuello uterino

    Rodríguez Velásquez, Javier Oswaldo


    Full Text Available Background: Pathological interpretation of cellular form in cervical cytology is very important for preven- tion of cervical cancer. The methods most frequently used for assessment of this test have reproducibility and inter-observer variability problems. Objective: To make fractal and Euclidean measure- ments to mathematically diagnose normal and pre- malignant cells of cervical squamous epithelium. Methodology: 21 cells with normal, ASCUS or LSIL diagnosis according to the Bethesda system were assessed. Fractal and Euclidean geometric measures of three mathematical objects were calculated: cyto- plasm, nucleus and whole cell. Mathematical propor- tions between these measurements were calculated in order to compare them with conventional classification methods. Results: It was found that the nuclear border measures calculated with the 2-pixel grill and the surface measures could mathematically and objectively differentiate normal cells from the pre-malignant ones (ASCUS and LSIL. Conclusions: An objective and reproducible diagnos- tic method was developed; it allows to identify the evolution towards malignant cellular states based on simultaneous fractal and Euclidean measures, estab- lishing the severity level of ASCUS and LSIL cells.

  6. Advanced Plasma Diagnostic Analysis using Neural Networks

    Tritz, Kevin; Reinke, Matt


    Machine learning techniques, specifically neural networks (NN), are used with sufficient internal complexity to develop an empirically weighted relationship between a set of filtered X-ray emission measurements and the electron temperature (Te) profile for a specific class of discharges on NSTX. The NN response matrix is used to calculate the Te profile directly from the filtered X-ray diode measurements which extends the electron temperature time response from the 60Hz Thomson Scattering profile measurements to fast timescales (>10kHz) and greatly expands the applicability of Te profile information to fast plasma phenomena, such as ELM dynamics. This process can be improved by providing additional information which helps the neural network refine the relationship between Te and the corresponding X-ray emission. NN supplement limited measurements of a particular quantity using related measurements with higher time or spatial resolution. For example, the radiated power (Prad) determined using resistive foil bolometers is related to similar measurements using AXUV diode arrays through a complex and slowly time-evolving quantum efficiency curve in the VUV spectral region. Results from a NN trained using Alcator C-Mod resistive foil bolometry and AXUV diodes are presented, working towards hybrid Prad measurements with the quantitative accuracy of resistive foil bolometers and with the enhanced temporal and spatial resolution of the unfiltered AXUV diode arrays. Work supported by Department of Energy Grant #: DE-FG02-09ER55012.

  7. Advances in the diagnostic imaging of pheochromocytomas

    Forssell-Aronsson E


    Full Text Available Eva Forssell-Aronsson1, Emil Schüler1, Håkan Ahlman21Department of Radiation Physics, 2Department of Surgery, Lundberg Laboratory of Cancer Research, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, SwedenAbstract: Pheochromocytomas (PCs and paragangliomas (PGLs are routinely localized by computed tomography (CT, magnetic resonance imaging (MRI, and metaiodobenzylguanidine (MIBG scintigraphy. CT can identify tumors with high sensitivity but rather low specificity. MRI has higher sensitivity and specificity than CT and is superior to detect extra-adrenal disease. Radioiodinated MIBG scintigraphy has been used for more than 30 years and is based on MIBG uptake via the norepinephrine transporter on the cell membrane. The technique is very useful for whole-body studies in case of multiple primary tumors or metastases. Tumors with sole production of dopamine usually cannot be visualized with MIBG and may require positron emission tomographic (PET studies with 18F-labeled radiotracers. Somatostatin receptor scintigraphy (SRS using the radiolabeled somatostatin analog octreotide (based on the expression of the somatostatin receptors 2 and 5 by the tumor can demonstrate PGL or metastases not visualized by MIBG. In this article, we review the use of MIBG scintigraphy to diagnose PC/PGL and compare the sensitivity and specificity with that of CT and MRI. We also describe the recent SRS and PET techniques and review the latest results of clinical studies by comparing these imaging modalities. Future perspectives of functional imaging modalities for PC/PGL are finally presented.Keywords: MIBG, scintigraphy, pheochromocytoma, paraganglioma, PET

  8. Determination of battery stability with advanced diagnostics.

    Lamb, Joshua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Torres-Castro, Loraine [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Orendorff, Christopher [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Dufek, Eric [Idaho National Lab. (INL), Idaho Falls, ID (United States); Walker, Lee [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ho, Chinh [Idaho National Lab. (INL), Idaho Falls, ID (United States)


    Lithium ion batteries for use in battery electric vehicles (BEVs) has seen considerable expansion over the last several years. It is expected that market share and the total number of BEVs will continue to increase over coming years and that there will be changes in the environmental and use conditions for BEV batteries. Specifically aging of the batteries and exposure to an increased number of crash conditions presents a distinct possibility that batteries may be in an unknown state posing danger to the operator, emergency response personnel and other support personnel. The present work expands on earlier efforts to explore the ability to rapidly monitor using impedance spectroscopy techniques and characterize the state of different battery systems during both typical operations and under abusive conditions. The work has found that it is possible to detect key changes in performance for strings of up to four cells in both series and parallel configurations for both typical and abusive response. As a method the sensitivity for detecting change is enhanced for series configurations. For parallel configurations distinct changes are more difficult to ascertain, but under abusive conditions and for key frequencies it is feasible to use current rapid impedance techniques to identify change. The work has also found it feasible to use rapid impedance as an evaluation method for underload conditions, especially for series strings of cells.

  9. Advanced laser diagnostics for diamond deposition research

    Kruger, C.H.; Owano, T.G.; Wahl, E.H. [Stanford Univ., CA (United States)


    Chemical Vapor Deposition (CVD) using thermal plasmas is attractive for diamond synthesis applications due to the inherently high reactant densities and throughput, but the associated high gas-phase collision rates in the boundary layer above the substrate produce steep thermal and species gradients which can drive the complex plasma chemistry away from optimal conditions. To understand and control these environments, accurate measurements of temperature and species concentrations within the reacting boundary layer are needed. This is challenging in atmospheric pressure reactors due to the highly luminous environment, steep thermal and species gradients, and small spatial scales. The applicability of degenerate four-wave mixing (DFWM) as a spectroscopic probe of atmospheric pressure reacting plasmas has been investigated. This powerful, nonlinear technique has been applied to the measurement of temperature and radical species concentrations in the boundary layer of a diamond growth substrate immersed in a flowing atmospheric pressure plasma. In-situ measurements of CH and C{sub 2} radicals have been performed to determine spatially resolved profiles of vibrational temperature, rotational temperature, and species concentration. Results of these measurements are compared with the predictions of a detailed numerical simulation.

  10. Molecular diagnostics and parasitic disease.

    Vasoo, Shawn; Pritt, Bobbi S


    Molecular parasitology represents an emerging field in microbiology diagnostics. Although most assays use nonstandardized, laboratory-developed methods, a few commercial systems have recently become available and are slowly being introduced into larger laboratories. In addition, a few methodologies show promise for use in field settings in which parasitic infections are endemic. This article reviews the available techniques and their applications to major parasitic diseases such as malaria, leishmaniasis, and trichomoniasis.

  11. The diagnostic utility of 3D-ESI rotating and moving dipole methodology in the pre-surgical evaluation of MRI-negative childhood epilepsy due to focal cortical dysplasia.

    Russo, Angelo; Lallas, Matt; Jayakar, Prasanna; Miller, Ian; Hyslop, Ann; Dunoyer, Catalina; Resnick, Trevor; Duchowny, Michael


    This study investigates whether a combined rotating dipole (RD) and moving dipole (MD) solution enhances three-dimensional electroencephalography (EEG) source imaging (3D-ESI) localization in magnetic resonance imaging (MRI)-negative pediatric patients with focal cortical dysplasia (FCD). We retrospectively selected 14 MRI-negative patients with FCD from a cohort of 60 pediatric patients previously used to evaluate the diagnostic utility of 3D-ESI in epilepsy surgery. Patients were younger than 18 years at time of surgery and had at least 1 year of outcome data. RD and MD models were constructed for each interictal spike or sharp wave, and it was determined whether each inverse algorithm localized within the surgical resection cavity (SRC). We also compared the 3D-ESI findings and surgical outcome with positron emission tomography (PET) and ictal single photon emission computed tomography (iSPECT). RD analyses revealed a high concordance with the SRC (78.6%), particularly for temporal lobe resection (100.0%), and showed superior localization compared to PET and iSPECT, with the highest correlation in FCD type I and temporal lobe resection. Furthermore, the RD method was superior to iSPECT in FCD type II cases and to PET in extratemporal resections. RD and MD results were comparable, but in 18.2% of patients with FCD type I with localizing RDs, the MD solution was only partially within the SRC; in all of these patients 3D-ESI also correlated with superior surgical outcome compared to PET and iSPECT, especially when RD and MD solutions were analyzed together. 3D-ESI in MRI-negative cases showed superior localization compared to iSPECT or PET, especially in FCD type I and temporal lobe epilepsy, and correlated with superior surgical outcome compared to iSPECT and PET at 1 year and 2 years postoperatively, especially when RD and MD solutions were analyzed together. These findings suggest that 3D-ESI based on a combined RD-MD solution improves surgical accuracy in

  12. Advanced Primary Epithelial Ovarian and Peritoneal Carcinoma-Does Diagnostic Accuracy of Preoperative CT Scan for Detection of Peritoneal Metastatic Sites Reflect into Prediction of Suboptimal Debulking? A Prospective Study.

    Bagul, Kiran; Vijaykumar, D K; Rajanbabu, Anupama; Antony, Mitchelle Aline; Ranganathan, Venkatesan


    Ovarian cancer is the seventh most common cancer in females worldwide. Optimal debulking is the standard treatment but possible only in 30-85% of advanced stages. Knowing exactly the disease extent preoperatively may predict suboptimal debulking. We analyzed diagnostic accuracy of preoperative CT scan in disease mapping and prediction of suboptimal debulking in a prospective observational study from March 2013 to May 2015 in a tertiary hospital. Adults below the age of 75 years with ECOG PS-0, 1, 2, clinically/radiologically newly diagnosed stage IIIc epithelial ovarian (EOC), and primary peritoneal carcinoma (PPC) were included. Neoadjuvant chemotherapy recipients were excluded. Preoperative multidetector CT (MDCT) scan showing deposits at 19 predetermined abdominopelvic sites were compared with the same sites seen at laparotomy and corresponding accuracies of CT scan calculated. Primary debulking surgery was done to achieve debulking to nil or less than 1-cm residual disease. Stepwise logistic regression models were used to determine the frequent suboptimal debulking sites and the predictive performance of the clinical and CT scan findings. A total of 36 patients were enrolled. The optimal debulking rate was 50%. The CT scan could detect the disease-bearing sites with overall sensitivity of 68.29%, specificity of 89%, accuracy of 78.07%, and positive and negative predictive values of 99 and 50.1%, respectively. Upon multivariate analysis, bowel mesentery (p 0.011) and omental extension (p 0.025) were associated with suboptimal debulking. CT scan accuracy at these sites (predictive performance) was 86.1%. We identified small bowel mesentery and omental extension (to spleen/stomach/colon) as sites associated with suboptimal debulking. MDCT accurately depicts peritoneal metastases, although sensitivity is reduced in certain areas of significance for optimal debulking. Further validation with more number of patients is warranted.


    Tetyana KOVALCHUK


    Full Text Available The article deals with the investigation of theoretical and methodological principles of situational analysis. The necessity of situational analysis is proved in modern conditions. The notion “situational analysis” is determined. We have concluded that situational analysis is a continuous system study which purpose is to identify dangerous situation signs, to evaluate comprehensively such signs influenced by a system of objective and subjective factors, to search for motivated targeted actions used to eliminate adverse effects of the exposure of the system to the situation now and in the future and to develop the managerial actions needed to bring the system back to norm. It is developed a methodological approach to the situational analysis, its goal is substantiated, proved the expediency of diagnostic, evaluative and searching functions in the process of situational analysis. The basic methodological elements of the situational analysis are grounded. The substantiation of the principal methodological elements of system analysis will enable the analyst to develop adaptive methods able to take into account the peculiar features of a unique object which is a situation that has emerged in a complex system, to diagnose such situation and subject it to system and in-depth analysis, to identify risks opportunities, to make timely management decisions as required by a particular period.

  14. Systematic reviews of diagnostic test accuracy.

    Leeflang, Mariska M G; Deeks, Jonathan J; Gatsonis, Constantine; Bossuyt, Patrick M M


    More and more systematic reviews of diagnostic test accuracy studies are being published, but they can be methodologically challenging. In this paper, the authors present some of the recent developments in the methodology for conducting systematic reviews of diagnostic test accuracy studies. Restrictive electronic search filters are discouraged, as is the use of summary quality scores. Methods for meta-analysis should take into account the paired nature of the estimates and their dependence on threshold. Authors of these reviews are advised to use the hierarchical summary receiver-operating characteristic or the bivariate model for the data analysis. Challenges that remain are the poor reporting of original diagnostic test accuracy studies and difficulties with the interpretation of the results of diagnostic test accuracy research.

  15. Diagnostic thoracoscopy

    Plavec Goran


    Full Text Available Diagnostic thoracoscopy in patients with pleural effusion of unclear origin mostly provides the correct diagnosis. Results from published reports of previous researches are not uniform. In 47 male and 20 female patients with pleural effusion of unknown etiology, after receiving negative results obtained from cytological finding of pleural effusion and percutaneous needle biopsy, thoracoscopy with biopsy of one or both pleurae was performed. Procedure was done in local anesthesia using Stortz rigid thoracoscope. In 37 patients with malignant disease (primary or metastatic diagnosis was confirmed histopathologically in 31 patient (81.12%. In 27 patients with inflammatory pleural disease diagnosis was confirmed histopathologically in 22 patients (81.4%. Among 11 patients with specific pleural effusions, tuberculosis was confirmed in 10 (90.91%. Normal finding in cases of spontaneous pneumothorax and pulmonary embolism was taken as a positive result. Total number of positive findings was 55 (82.10%. In one patient, the third spontaneous pneumothorax was the indication for thoracoscopy, and after numerous bullae were seen during the procedure, talcum powder pleurodesis was done. In four patients low intensity subcutaneous emphysema occurred one day after thoracoscopy. It can be concluded that thoracoscopy in local anesthesia out of the operating room is good and practical method for solving the unclear pleural effusions, with neglectable rate of complications.

  16. Systematic reviews of diagnostic test accuracy

    Leeflang, Mariska M G; Deeks, Jonathan J; Gatsonis, Constantine


    More and more systematic reviews of diagnostic test accuracy studies are being published, but they can be methodologically challenging. In this paper, the authors present some of the recent developments in the methodology for conducting systematic reviews of diagnostic test accuracy studies....... Restrictive electronic search filters are discouraged, as is the use of summary quality scores. Methods for meta-analysis should take into account the paired nature of the estimates and their dependence on threshold. Authors of these reviews are advised to use the hierarchical summary receiver...

  17. Treatment of locally advanced rectal cancer

    Klaassen, RA; Nieuwenhuijzen, GAP; Martijn, H; Rutten, HJT; Hospers, GAP; Wiggers, T


    Historically, locally advanced rectal cancer is known for its dismal prognosis. The treatment of locally advanced rectal cancer is subject to continuous change due to development of new and better diagnostic tools, radiotherapeutic techniques, chemotherapeutic agents and understanding of the

  18. Diagnostics and Microelectronics

    Balch, J.W.


    This report discusses activities of the Diagnostics and Microelectronics thrust area which conducts activities in semiconductor devices and semiconductor fabrication technology for programs at Lawrence Livermore National Laboratory. Our multidisciplinary engineering and scientific staff use modern computational tools and semi-conductor microfabrication equipment to develop high-performance devices. Our work concentrates on three broad technologies of semiconductor microdevices: (1) silicon on III-V semiconductor microeletronics, (2) lithium niobate-based and III-V semiconductor-based photonics, and (3) silicon-based micromaching for application to microstructures and microinstruments. In FY-92, we worked on projects in seven areas, described in this report: novel photonic detectors; a wideband phase modulator; an optoelectronic terahertz beam system; the fabrication of microelectrode electrochemical sensors; diamond heatsinks; advanced micromachining technologies; and electrophoresis using silicon microchannels.

  19. Imaging Techniques for Microwave Diagnostics

    Donne, T. [FOM-Institute for Plasma Physics Rijnhuizen, Trilateral Euregio Cluster, PO Box 1207, 3430 BE Nieuwegein (Netherlands); Luhmann Jr, N.C. [University of California, Davis, CA 95616 (United States); Park, H.K. [POSTECH, Pohang, Gyeongbuk 790-784 (Korea, Republic of); Tobias, B.


    Advances in microwave technology have made it possible to develop a new generation of microwave imaging diagnostics for measuring the parameters of magnetic fusion devices. The most prominent of these diagnostics is electron cyclotron emission imaging (ECE-I). After the first generation of ECE-I diagnostics utilized at the TEXT-U, RTP and TEXTOR tokamaks and the LHD stellarator, new systems have recently come into operation on ASDEX-UG and DIII-D, soon to be followed by a system on KSTAR. The DIII-D and KSTAR systems feature dual imaging arrays that observe different parts of the plasma. The ECE-I diagnostic yields two-dimensional movies of the electron temperature in the plasma and has given already new insights into the physics of sawtooth oscillations, tearing modes and edge localized modes. Microwave Imaging Reflectometry (MIR) is used on LHD to measure electron density fluctuations. A pilot MIR system has been tested at TEXTOR and, based on the promising results, a new system is now under design for KSTAR. The system at TEXTOR was used to measure the plasma rotation velocity. The system at KSTAR and also the one on LHD will be/are used for measuring the profile of the electron density fluctuations in the plasma. Other microwave imaging diagnostics are phase imaging interferometry, and imaging microwave scattering. The emphasis in this paper will be largely focused on ECE-I. First an overview of the advances in microwave technology are discussed, followed by a description of a typical ECE-I system along with some typical experimental results. Also the utilization of imaging techniques in other types of microwave diagnostics will be briefly reviewed. This document is composed of the slides of the presentation. (authors)

  20. A review of solutions for diagnostic accuracy studies with an imperfect or missing reference standard

    J.B. Reitsma; A.W.S. Rutjes; K.S. Khan; A. Coomarasamy; P.M. Bossuyt


    Objective: In diagnostic accuracy studies, the reference standard may be imperfect or not available in all patients. We systematically reviewed the proposed solutions for these situations and generated methodological guidance. Study Design and Setting: Review of methodological articles. Results: We

  1. The necessity of the establishment of standardized diagnostic methodology and treatment pattern of retinoblastoma in China%关于在我国建立视网膜母细胞瘤规范化诊疗模式必要性的思考



    通过介绍视网膜母细胞瘤新的国际诊断分期标准及常规治疗方法,比较国内、国外治疗的现状和差距,总结提出了我国视网膜母细胞瘤诊疗过程中亟待解决的问题,建议在我国建立并推广规范化的视网膜母细胞瘤诊疗模式,并强调了眼科病理诊断在视网膜母细胞瘤高危因素评估以及后续治疗中的重要指导作用.%This article describes the new international classification and routine treatment methods of retinoblastoma,compares the status and gaps between domestic and foreign treatments,summarizes and presents problems to be solved in the treatment process of retinoblastoma domestically,presents suggestions in establishing and promoting a standardized diagnostic methodology and treatment pattern in China,and emphasizes the important guiding role of pathological diagnosis in ophthalmology for retinoblastoma risk factor assessment and subsequent treatment.

  2. Cancer cytogenetics: methodology revisited.

    Wan, Thomas S K


    The Philadelphia chromosome was the first genetic abnormality discovered in cancer (in 1960), and it was found to be consistently associated with CML. The description of the Philadelphia chromosome ushered in a new era in the field of cancer cytogenetics. Accumulating genetic data have been shown to be intimately associated with the diagnosis and prognosis of neoplasms; thus, karyotyping is now considered a mandatory investigation for all newly diagnosed leukemias. The development of FISH in the 1980s overcame many of the drawbacks of assessing the genetic alterations in cancer cells by karyotyping. Karyotyping of cancer cells remains the gold standard since it provides a global analysis of the abnormalities in the entire genome of a single cell. However, subsequent methodological advances in molecular cytogenetics based on the principle of FISH that were initiated in the early 1990s have greatly enhanced the efficiency and accuracy of karyotype analysis by marrying conventional cytogenetics with molecular technologies. In this review, the development, current utilization, and technical pitfalls of both the conventional and molecular cytogenetics approaches used for cancer diagnosis over the past five decades will be discussed.

  3. Far infrared fusion plasma diagnostics

    Luhmann, N.C. Jr.; Peebles, W.A.


    Over the last several years, reflectometry has grown in importance as a diagnostic for both steady-state density Profiles as well as for the investigation of density fluctuations and turbulence. As a diagnostic for density profile measurement, it is generally believed to be well understood in the tokamak environment. However, its use as a fluctuation diagnostic is hampered by a lack of quantitative experimental understanding of its wavenumber sensitivity and spatial resolution. Several researchers, have theoretically investigated these questions. However, prior to the UCLA laboratory investigation, no group has experimentally investigated these questions. Because of the reflectometer's importance to the world effort in understanding plasma turbulence and transport, UCLA has, over the last year, made its primary Task IIIA effort the resolution of these questions. UCLA has taken the lead in a quantitative experimental understanding of reflectometer data as applied to the measurement of density fluctuations. In addition to this, work has proceeded on the design, construction, and installation of a reflectometer system on UCLA's CCT tokamak. This effort will allow a comparison between the improved confinement regimes (H-mode) observed on both the DIII-D and CCT machines with the goal of achieving a physics understanding of the phenomena. Preliminary investigation of a new diagnostic technique to measure density profiles as a function of time has been initiated at UCLA. The technique promises to be a valuable addition to the range of available plasma diagnostics. Work on advanced holographic reflectometry technique as applied to fluctuation diagnostics has awaited a better understanding of the reflectometer signal itself as discussed above. Efforts to ensure the transfer of the diagnostic developments have continued with particular attention devoted to the preliminary design of a multichannel FIR interferometer for MST.

  4. Evaluation of costs and benefits of advances in cytologic technology. International Academy of Cytology Task Force summary. Diagnostic Cytology Towards the 21st Century: An International Expert Conference and Tutorial.

    Melamed, M R; Hutchinson, M L; Kaufman, E A; Schechter, C B; Garner, D; Kobler, T P; Krieger, P A; Reith, A; Schenck, U


    Uterine cervical cytology smears are among the most cost-effective cancer prevention interventions available, but they are not infallible, and new or modified technologies have been and will be proposed to improve diagnostic accuracy. Before these new technologies are accepted, their performance attributes will be carefully studied and defined. Equally important in this era of fiscal constraints are cost/benefit analyses, for which we review certain guidelines. In an effort to control rising costs in the health care sector, there has been a strong incentive to move toward a market system, and a variety of forces are acting to drive down expenditures. These same pressures will continue to be brought to bear on the providers of cervical cytology services. It must be emphasized that the technical knowledge required to define cost-effective medical practice lies within the medical profession itself, which must recognize the following: (a) Resources are finite; (b) Elimination of fraud, abuse and waste is not enough to bring health care expenditures down to levels considered acceptable to government and business; (c) The medical profession must take the responsibility to identify the health and economic consequences of the services it provides and make wise recommendations for allocation of resources to optimize health consequences. The analysis of costs and benefits must be viewed from a societal perspective and presented in terms of the marginal impact on current practice. This does not mean that new technologies must reduce cost; on the contrary, improvements in health can be expected to come at a price, but at a price commensurate with value gained in lives saved or in added quality adjusted life years. To be of value, a new technology for cervical cytology must be more effective in preventing cervical carcinoma. Dysplasia is considered a precursor of carcinoma, and detection of dysplasia has been a surrogate for prevention of cervical carcinoma, but dysplasia does

  5. TRAGG best estimate methodology applications

    Hoang, H.


    The TRACG model simulates a multi-dimensional vessel and contains a flexible modular structure with control system capability. TRACG has undergone benchmarking qualifications with extensive testing and actual plant data. This best estimate methodology has been used widely in BWR safety analyses as well as in the qualification of the GEH advanced BWR designs. The application of TRACG methodology for loss of coolant accident (LOCA) analyses will provide realistic fuel bundle thermal responses. By taking advantage of these additional margins, the utility owner can justify the optimization of plant-specific emergency core cooling system performance requirements and justify certain equipment declared inoperable. The resulting benefits are improved plant capacity and reliability and improved equipment reliability and lifetime. (Author)


    Charul Deewan


    Full Text Available The technologies are numerous and Software is the one whichis most widely used. Some companies have their owncustomized methodology for developing their software but themajority speaks about two kinds of methodologies: Traditionaland Agile methodologies. In this paper, we will discuss someof the aspects of what Agile methodology is, how it can beused to get the best result from a project, how do we get it towork in an organization.

  7. Language Policy and Methodology

    Liddicoat, Antony J.


    The implementation of a language policy is crucially associated with questions of methodology. This paper explores approaches to language policy, approaches to methodology and the impact that these have on language teaching practice. Language policies can influence decisions about teaching methodologies either directly, by making explicit…

  8. Decision analysis to complete diagnostic research by closing the gap between test characteristics and cost-effectiveness

    Schaafsma, Joanna D.; van der Graaf, Yolanda; Rinkel, Gabriel J. E.; Buskens, Erik


    Objective: The lack of a standard methodology in diagnostic research impedes adequate evaluation before implementation of constantly developing diagnostic techniques. We discuss the methodology of diagnostic research and underscore the relevance of decision analysis in the process of evaluation of d

  9. Observations and diagnostics in high brightness beams

    Cianchi, A., E-mail: [University of Rome Tor Vergata and INFN-Roma Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome (Italy); Anania, M.P.; Bisesto, F.; Castellano, M.; Chiadroni, E.; Pompili, R.; Shpakov, V. [INFN-LNF, Via Enrico Fermi 40, 00044 Frascati (Italy)


    The brightness is a figure of merit largely used in the light sources, like FEL (Free Electron Lasers), but it is also fundamental in several other applications, as for instance Compton backscattering sources, beam driven plasma accelerators and THz sources. Advanced diagnostics are essential tools in the development of high brightness beams. 6D electron beam diagnostics will be reviewed with emphasis on emittance measurement.

  10. Advanced healthcare materials

    Tiwari, Ashutosh


    Advanced materials are attracting strong interest in the fundamental as well as applied sciences and are being extensively explored for their potential usage in a range of healthcare technological and biological applications. Advanced Healthcare Nanomaterials summarises the current status of knowledge in the fields of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, up and coming bio-engineering devices. The book highlights the key features which enable engineers to design stimuli-responsive smart nanoparticles, novel biomaterials, nan

  11. Welcome to Diagnostics: a New Open Access Journal for the Fast-Growing Field of Medical Diagnostics

    Andreas Kjaer


    Full Text Available Diagnostic methods in medicine are currently rapidly evolving and constantly improving. This is true for areas such as molecular diagnostics, biomarkers, as well as medical imaging. As one example, positron emission tomography (PET has been called the fastest growing medical technology ever. Also, molecular diagnostics, at both the gene and protein levels, are developing rapidly due to advances in technology and, thereby, creating new possibilities. Early and valid diagnosis is crucial for proper treatment of patients. Moreover, advanced diagnostic methods are crucial for the upcoming era of tailored therapy. From an economic viewpoint, the cost of advanced treatments are increasingly indicating the need for better stratification and therapy monitoring of treatment, in order that these advanced treatments are limited to patients able to respond favorably. Collectively, the exciting area of medical diagnostics seems never to have been more important for patients and society. [...

  12. Gas turbine gas path diagnostics: A review

    Fentaye Amare Desalegn


    Full Text Available In this competitive business world one way to increase profitability of a power production unit is to reduce the operation and maintenance expenses. This is possible if the gas turbine availability and reliability is improved using the appropriate maintenance action at the right time. In that case, fault diagnostics is very critical and effective and advanced methods are essential. Gas turbine diagnostics has been studied for the past six decades and several methods are introduced. This paper aims to review and summarise the published literature on gas path diagnostics, giving more emphasis to the recent developments, and identify advantages and limitations of the methods so that beginners in diagnostics can easily be introduced. Towards this end, this paper, identifies various diagnostic methods and point out their pros and cons. Finally, the paper concludes the review along with some recommended future works.

  13. Electrochemical Biosensors for Early Stage Zika Diagnostics.

    Kaushik, Ajeet; Tiwari, Sneham; Jayant, Rahul D; Vashist, Arti; Nikkhah-Moshaie, Roozbeh; El-Hage, Nazira; Nair, Madhavan


    Health agencies have declared the recent Zika virus (ZIKV) infection an epidemic and a public health emergency of global concern due to its association with microcephaly and serious neurological disorders. The unavailability of effective drugs, vaccines, and diagnostic tools increases the demand for efficient analytical devices to detect ZIKV infection. However, high costs, longer diagnostic times, and stringent expertise requirements limit the utility of reverse transcriptase-PCR methods for rapid diagnostics. Therefore, developing portable, sensitive, selective, and cost-effective sensing systems to detect ZIKV at picomolar concentrations in biofluids would be a breakthrough in diagnostics and therapeutics. This paper highlights the advancements in developing smart sensing strategies to monitor ZIKV progression, with rapid point-of-care diagnostics as the ultimate aim.

  14. International Workshop on Diagnostics for ITER

    Gorini, Giuseppe; Sindoni, Elio


    This book of proceedings collects the papers presented at the Workshop on Diagnostics for ITER, held at Villa Monastero, Varenna (Italy), from August 28 to September 1, 1995. The Workshop was organised by the International School of Plasma Physics "Piero Caldirola. " Established in 1971, the ISPP has organised over fifty advanced courses and workshops on topics mainly related to plasma physics. In particular, courses and workshops on plasma diagnostics (previously held in 1975, 1978, 1982, 1986, and 1991) can be considered milestones in the history of this institution. Looking back at the proceedings of the previous meetings in Varenna, one can appreciate the rapid progress in the field of plasma diagnostics over the past 20 years. The 1995 workshop was co-organised by the Istituto di Fisica del Plasma of the National Research Council (CNR). In contrast to previous Varenna meetings on diagnostics, which have covered diagnostics in present-day tokamaks and which have had a substantial tutorial component, the 1...

  15. Optical diagnostics of osteoblast cells and osteogenic drug screening

    Kolanti, Elayaraja; Veerla, Sarath C.; Khajuria, Deepak K.; Roy Mahapatra, D.


    Microfluidic device based diagnostics involving optical fibre path, in situ imaging and spectroscopy are gaining importance due to recent advances in diagnostics instrumentation and methods, besides other factors such as low amount of reagent required for analysis, short investigation times, and potential possibilities to replace animal model based study in near future. It is possible to grow and monitor tissues in vitro in microfluidic lab-on-chip. It may become a transformative way of studying how cells interact with drugs, pathogens and biomaterials in physiologically relevant microenvironments. To a large extent, progress in developing clinically viable solutions has been constrained because of (i) contradiction between in vitro and in vivo results and (ii) animal model based and clinical studies which is very expensive. Our study here aims to evaluate the usefulness of microfluidic device based 3D tissue growth and monitoring approach to better emulate physiologically and clinically relevant microenvironments in comparison to conventional in vitro 2D culture. Moreover, the microfluidic methodology permits precise high-throughput investigations through real-time imaging while using very small amounts of reagents and cells. In the present study, we report on the details of an osteoblast cell based 3D microfluidic platform which we employ for osteogenic drug screening. The drug formulation is functionalized with fluorescence and other biomarkers for imaging and spectroscopy, respectively. Optical fibre coupled paths are used to obtain insight regarding the role of stress/flow pressure fluctuation and nanoparticle-drug concentration on the osteoblast growth and osteogenic properties of bone.

  16. Methodological issues of postoperative cognitive dysfunction research

    Funder, Kamilia S; Steinmetz, Jacob; Rasmussen, Lars S


    Postoperative cognitive dysfunction (POCD) is a subtle impairment of memory, concentration, and speed of information processing. It is a frequent complication following surgery and can have a debilitating effect on patients' recovery and future prognosis. Neuropsychological testing is needed...... to reveal postoperative cognitive decline, and questionnaires are not useful for this purpose. There is a profound lack of consensus regarding the research methodology for detection of cognitive deterioration, especially the diagnostic criteria. Issues, such as baseline performance, learning effects...

  17. DNA Microarray-Based Diagnostics.

    Marzancola, Mahsa Gharibi; Sedighi, Abootaleb; Li, Paul C H


    The DNA microarray technology is currently a useful biomedical tool which has been developed for a variety of diagnostic applications. However, the development pathway has not been smooth and the technology has faced some challenges. The reliability of the microarray data and also the clinical utility of the results in the early days were criticized. These criticisms added to the severe competition from other techniques, such as next-generation sequencing (NGS), impacting the growth of microarray-based tests in the molecular diagnostic market.Thanks to the advances in the underlying technologies as well as the tremendous effort offered by the research community and commercial vendors, these challenges have mostly been addressed. Nowadays, the microarray platform has achieved sufficient standardization and method validation as well as efficient probe printing, liquid handling and signal visualization. Integration of various steps of the microarray assay into a harmonized and miniaturized handheld lab-on-a-chip (LOC) device has been a goal for the microarray community. In this respect, notable progress has been achieved in coupling the DNA microarray with the liquid manipulation microsystem as well as the supporting subsystem that will generate the stand-alone LOC device.In this chapter, we discuss the major challenges that microarray technology has faced in its almost two decades of development and also describe the solutions to overcome the challenges. In addition, we review the advancements of the technology, especially the progress toward developing the LOC devices for DNA diagnostic applications.

  18. Optical Diagnostics in Medicine

    Iftimia, Nicusor


    Light has a unique potential for non-invasive tissue diagnosis. The relatively short wavelength of light allows imaging of tissue at the resolution of histopathology. While strong multiple scattering of light in tissue makes attainment of this resolution difficult for thick tissues, most pathology emanates from epithelial surfaces. Therefore, high-resolution diagnosis of many important diseases may be achieved by transmitting light to the surface of interest. The recent fiber-optic implementation of technologies that reject multiple scattering, such as confocal microscopy and optical low coherence interferometry, have brought us one step closer to realizing non-invasive imaging of architectural and cellular features of tissue. Optical coherence tomography (OCT) can produce high-resolution cross-sectional images of biological structures. Clinical OCT studies conducted in the gastrointestinal tract and cardiovascular system have shown that OCT is capable of providing images of the architectural (> 20 µm) microanatomy of a variety of epithelial tissues, including the layered structure of squamous epithelium and arterial vessels. Fine Needle Aspiration- Low Coherence Interferometry (FNA-LCI) is another optical diagnostics technique, which is a suitable solution to increase the effectiveness of the FNA procedures. LCI is capable of measuring depth resolved (axial, z) tissue structure, birefringence, flow (Doppler shift), and spectra at a resolution of several microns. Since LCI systems are fiber-optic based, LCI probes may easily fit within the bore of a fine gauge needle, allowing diagnostic information to be obtained directly from the FNA biopsy site. Fiber optic spectrally encoded confocal microscopy (SECM) is a new confocal microscopy method, which eliminates the need for rapid beam scanning within the optical probe. This advance enables confocal microscopy to be performed through small diameter probes and will allow assessment of internal human tissues in vivo at

  19. Discovery and validation of plasma-protein biomarker panels for the detection of colorectal cancer and advanced adenoma in a Danish collection of samples from patients referred for diagnostic colonoscopy

    Blume, John E.; Wilhelmsen, Michael; Benz, Ryan W.


    and utilization of such a resource is an important step in the development of blood-based biomarker tests for colorectal cancer.Methods: We have created a subject data and biological sample resource, Endoscopy II, which is based on 4698 individuals referred for diagnostic colonoscopy in Denmark between May 2010...

  20. Reliability Centered Maintenance - Methodologies

    Kammerer, Catherine C.


    Journal article about Reliability Centered Maintenance (RCM) methodologies used by United Space Alliance, LLC (USA) in support of the Space Shuttle Program at Kennedy Space Center. The USA Reliability Centered Maintenance program differs from traditional RCM programs because various methodologies are utilized to take advantage of their respective strengths for each application. Based on operational experience, USA has customized the traditional RCM methodology into a streamlined lean logic path and has implemented the use of statistical tools to drive the process. USA RCM has integrated many of the L6S tools into both RCM methodologies. The tools utilized in the Measure, Analyze, and Improve phases of a Lean Six Sigma project lend themselves to application in the RCM process. All USA RCM methodologies meet the requirements defined in SAE JA 1011, Evaluation Criteria for Reliability-Centered Maintenance (RCM) Processes. The proposed article explores these methodologies.

  1. Scenario development methodologies

    Eng, T. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Hudson, J. [Rock Engineering Consultants, Welwyn Garden City, Herts (United Kingdom); Stephansson, O. [Royal Inst. of Tech., Stockholm (Sweden). Div. of Engineering Geology; Skagius, K.; Wiborgh, M. [Kemakta, Stockholm (Sweden)


    In the period 1981-1994, SKB has studied several methodologies to systematize and visualize all the features, events and processes (FEPs) that can influence a repository for radioactive waste in the future. All the work performed is based on the terminology and basic findings in the joint SKI/SKB work on scenario development presented in the SKB Technical Report 89-35. The methodologies studied are (a) Event tree analysis, (b) Influence diagrams and (c) Rock Engineering Systems (RES) matrices. Each one of the methodologies is explained in this report as well as examples of applications. One chapter is devoted to a comparison between the two most promising methodologies, namely: Influence diagrams and the RES methodology. In conclusion a combination of parts of the Influence diagram and the RES methodology is likely to be a promising approach. 26 refs.


    Antony J. Liddicoat


    Full Text Available The implementation of a language policy is crucially associated with questions of methodology. This paper explores approaches to language policy, approaches to methodology and the impact that these have on language teaching practice. Language policies can influence decisions about teaching methodologies either directly, by making explicit recommendations about the methods to be used in classroom practice, or indirectly, through the conceptualisation of language leaming which underlies the policy. It can be argued that all language policies have the potential to influence teaching methodologies indirectly and that those policies which have explicit recommendations about methodology are actually functioning of two levels. This allows for the possibility of conflict between the direct and indirect dimensions of the policy which results from an inconsistency between the explicitly recommended methodology and the underlying conceptualisation of language teaching and learning which informs the policy.

  3. Open verification methodology cookbook

    Glasser, Mark


    Functional verification is an art as much as a science. It requires not only creativity and cunning, but also a clear methodology to approach the problem. The Open Verification Methodology (OVM) is a leading-edge methodology for verifying designs at multiple levels of abstraction. It brings together ideas from electrical, systems, and software engineering to provide a complete methodology for verifying large scale System-on-Chip (SoC) designs. OVM defines an approach for developing testbench architectures so they are modular, configurable, and reusable. This book is designed to help both novic


    Pezelj-Ribarić Sonja


    Full Text Available Saliva is a readily available oral fluid with many functions, from digestion, maintenance of oral tissues' integrity, to caries prevention. Changes regarding its secretion may be divided into qualitative and quantitative: both of them are a consequence of certain conditions/diseases (e.g. internal factors or nutrients/drugs ingested (e.g. external factors. During the last 15 years, technological advances gave a significant momentum to utilization of saliva as a diagnostic tool. Analysis of saliva, just like the blood analysis, has two main objectives: to identify the subjects suffering from a certain disorder, and to follow the development and progress of therapy. This paper provides an overview of possibilities for the use of saliva for diagnostic purposes and gives specific examples of some clinical investigations, with the final aim to stimulate the use of this noninvasive means for the health care promotion.

  5. The methodological defense of realism scrutinized.

    Wray, K Brad


    I revisit an older defense of scientific realism, the methodological defense, a defense developed by both Popper and Feyerabend. The methodological defense of realism concerns the attitude of scientists, not philosophers of science. The methodological defense is as follows: a commitment to realism leads scientists to pursue the truth, which in turn is apt to put them in a better position to get at the truth. In contrast, anti-realists lack the tenacity required to develop a theory to its fullest. As a consequence, they are less likely to get at the truth. My aim is to show that the methodological defense is flawed. I argue that a commitment to realism does not always benefit science, and that there is reason to believe that a research community with both realists and anti-realists in it may be better suited to advancing science. A case study of the Copernican Revolution in astronomy supports this claim.

  6. An advance triage system.

    Cheung, W W H; Heeney, L; Pound, J L


    This paper describes the redesign of the triage process in an Emergency Department with the purpose of improving the patient flow and thus increasing patient satisfaction through the reduction of the overall length of stay. The process, Advance Triage, allows the triage nurse to initiate diagnostic protocols for frequently occurring medical problems based on physician-approved algorithms. With staff and physician involvement and medical specialist approval, nine Advance Triage algorithms were developed-abdominal pain, eye trauma, chest pain, gynaecological symptoms, substance abuse, orthopaedic trauma, minor trauma, paediatric fever and paediatric emergent. A comprehensive educational program was provided to the triage nurses and Advance Triage was initiated. A process was established at one year to evaluate the effectiveness of the Advance Triage System. The average length of stay was found to be 46 min less for all patients who were advance triaged with the greatest time-saving of 76 min for patients in the 'Urgent' category. The most significant saving was realized in the patient's length of stay (LOS) after the Emergency Physician assessed them because diagnostic results, available during the initial patient assessment, allowed treatment decisions to be made at that time. Advance Triage utilizes patient waiting time efficiently and increases the nurses' and physicians' job satisfaction.

  7. Tuberculosis diagnostics: innovating to make an impact.

    Ghanashyam, Bharathi


    The 'International Symposium on TB Diagnostics: Innovating to Make an Impact' was organized by the International Centre for Genetic Engineering & Biotechnology, New Delhi, India, on December 16-17, 2010, with sponsorship support from the Bill & Melinda Gates Foundation, Foundation for Innovative New Diagnostics and AERAS Global TB Vaccine Foundation. This highly successful symposium attracted more than 300 participants from India and several other countries and covered several aspects of TB diagnostics, including recent scientific advances in TB diagnostics, progress made in expanding the TB diagnostics pipeline including a portfolio of WHO-endorsed, validated new tools and improved technologies, the successful development of newer molecular assays that have the potential to be used at the point of treatment and the growing contributions of emerging economies such as India. In addition to highlighting the positive aspects of TB diagnostics, the symposium speakers also highlighted the need to focus on worrisome aspects of TB diagnosis, including widespread abuse of inappropriate tests that can prevent the use of good diagnostics, lack of quality assurance in laboratories, lack of adequate regulation of diagnostics and how these can pose a major challenge for roll-out and implementation of new tools. The symposium ended with a very stimulating discussion on how India can become a global leader in TB innovations.

  8. Thioaptamer Diagnostic System Project

    National Aeronautics and Space Administration — AM Biotechnologies (AM) will develop a diagnostic system in response to SBIR Topic X10.01 Reusable Diagnostic Lab Technology that will simultaneously detect and...

  9. Diagnostic Algorithm Benchmarking

    Poll, Scott


    A poster for the NASA Aviation Safety Program Annual Technical Meeting. It describes empirical benchmarking on diagnostic algorithms using data from the ADAPT Electrical Power System testbed and a diagnostic software framework.

  10. Data Centric Development Methodology

    Khoury, Fadi E.


    Data centric applications, an important effort of software development in large organizations, have been mostly adopting a software methodology, such as a waterfall or Rational Unified Process, as the framework for its development. These methodologies could work on structural, procedural, or object oriented based applications, but fails to capture…

  11. Creativity in phenomenological methodology

    Dreyer, Pia; Martinsen, Bente; Norlyk, Annelise


    on the methodologies of van Manen, Dahlberg, Lindseth & Norberg, the aim of this paper is to argue that the increased focus on creativity and arts in research methodology is valuable to gain a deeper insight into lived experiences. We illustrate this point through examples from empirical nursing studies, and discuss...

  12. The Methodology of Magpies

    Carter, Susan


    Arts/Humanities researchers frequently do not explain methodology overtly; instead, they "perform" it through their use of language, textual and historic cross-reference, and theory. Here, methodologies from literary studies are shown to add to Higher Education (HE) an exegetical and critically pluralist approach. This includes…

  13. Menopause and Methodological Doubt

    Spence, Sheila


    Menopause and methodological doubt begins by making a tongue-in-cheek comparison between Descartes' methodological doubt and the self-doubt that can arise around menopause. A hermeneutic approach is taken in which Cartesian dualism and its implications for the way women are viewed in society are examined, both through the experiences of women…

  14. The Methodology of Magpies

    Carter, Susan


    Arts/Humanities researchers frequently do not explain methodology overtly; instead, they "perform" it through their use of language, textual and historic cross-reference, and theory. Here, methodologies from literary studies are shown to add to Higher Education (HE) an exegetical and critically pluralist approach. This includes…

  15. VEM: Virtual Enterprise Methodology

    Tølle, Martin; Vesterager, Johan


    This chapter presents a virtual enterprise methodology (VEM) that outlines activities to consider when setting up and managing virtual enterprises (VEs). As a methodology the VEM helps companies to ask the right questions when preparing for and setting up an enterprise network, which works...

  16. VEM: Virtual Enterprise Methodology

    Tølle, Martin; Vesterager, Johan


    This chapter presents a virtual enterprise methodology (VEM) that outlines activities to consider when setting up and managing virtual enterprises (VEs). As a methodology the VEM helps companies to ask the right questions when preparing for and setting up an enterprise network, which works as a b...

  17. Menopause and Methodological Doubt

    Spence, Sheila


    Menopause and methodological doubt begins by making a tongue-in-cheek comparison between Descartes' methodological doubt and the self-doubt that can arise around menopause. A hermeneutic approach is taken in which Cartesian dualism and its implications for the way women are viewed in society are examined, both through the experiences of women…

  18. Rapid Dialogue Prototyping Methodology

    Bui Huu Trung, B.H.T.; Sojka, P.; Rajman, M.; Kopecek, I.; Melichar, M.; Pala, K.


    This paper is about the automated production of dialogue models. The goal is to propose and validate a methodology that allows the production of finalized dialogue models (i.e. dialogue models specific for given applications) in a few hours. The solution we propose for such a methodology, called the

  19. Climate Model Diagnostic Analyzer Web Service System

    Lee, S.; Pan, L.; Zhai, C.; Tang, B.; Kubar, T. L.; Li, J.; Zhang, J.; Wang, W.


    Both the National Research Council Decadal Survey and the latest Intergovernmental Panel on Climate Change Assessment Report stressed the need for the comprehensive and innovative evaluation of climate models with the synergistic use of global satellite observations in order to improve our weather and climate simulation and prediction capabilities. The abundance of satellite observations for fundamental climate parameters and the availability of coordinated model outputs from CMIP5 for the same parameters offer a great opportunity to understand and diagnose model biases in climate models. In addition, the Obs4MIPs efforts have created several key global observational datasets that are readily usable for model evaluations. However, a model diagnostic evaluation process requires physics-based multi-variable comparisons that typically involve large-volume and heterogeneous datasets, making them both computationally- and data-intensive. In response, we have developed a novel methodology to diagnose model biases in contemporary climate models and implementing the methodology as a web-service based, cloud-enabled, provenance-supported climate-model evaluation system. The evaluation system is named Climate Model Diagnostic Analyzer (CMDA), which is the product of the research and technology development investments of several current and past NASA ROSES programs. The current technologies and infrastructure of CMDA are designed and selected to address several technical challenges that the Earth science modeling and model analysis community faces in evaluating and diagnosing climate models. In particular, we have three key technology components: (1) diagnostic analysis methodology; (2) web-service based, cloud-enabled technology; (3) provenance-supported technology. The diagnostic analysis methodology includes random forest feature importance ranking, conditional probability distribution function, conditional sampling, and time-lagged correlation map. We have implemented the

  20. Preliminary safety analysis methodology for the SMART

    Bae, Kyoo Hwan; Chung, Y. J.; Kim, H. C.; Sim, S. K.; Lee, W. J.; Chung, B. D.; Song, J. H. [Korea Atomic Energy Research Institute, Taejeon (Korea)


    This technical report was prepared for a preliminary safety analysis methodology of the 330MWt SMART (System-integrated Modular Advanced ReacTor) which has been developed by Korea Atomic Energy Research Institute (KAERI) and funded by the Ministry of Science and Technology (MOST) since July 1996. This preliminary safety analysis methodology has been used to identify an envelope for the safety of the SMART conceptual design. As the SMART design evolves, further validated final safety analysis methodology will be developed. Current licensing safety analysis methodology of the Westinghouse and KSNPP PWRs operating and under development in Korea as well as the Russian licensing safety analysis methodology for the integral reactors have been reviewed and compared to develop the preliminary SMART safety analysis methodology. SMART design characteristics and safety systems have been reviewed against licensing practices of the PWRs operating or KNGR (Korean Next Generation Reactor) under construction in Korea. Detailed safety analysis methodology has been developed for the potential SMART limiting events of main steam line break, main feedwater pipe break, loss of reactor coolant flow, CEA withdrawal, primary to secondary pipe break and the small break loss of coolant accident. SMART preliminary safety analysis methodology will be further developed and validated in parallel with the safety analysis codes as the SMART design further evolves. Validated safety analysis methodology will be submitted to MOST as a Topical Report for a review of the SMART licensing safety analysis methodology. Thus, it is recommended for the nuclear regulatory authority to establish regulatory guides and criteria for the integral reactor. 22 refs., 18 figs., 16 tabs. (Author)

  1. Long distance transmission of diagnostic cardiovascular information.

    Caldwell, M A; Miles, R; Barrington, W


    Availability of advanced cardiac diagnostic procedures has proven to decrease the morbidity and mortality associated with common cardiovascular diseases. It was requested that the University of Nebraska Medical Center (UNMC) provide a rural hospital with advanced cardiology services. The services included monitoring of inpatients and rapid interpretation of cardiac diagnostic tests. UNMC proposed to solve this problem by building a computer-based system to transmit diagnostic cardiac information from a rural hospital to UNMC for interpretation by a cardiologist. The information transmitted to UNMC was grouped into two categories: 1) cardiovascular ultrasound, 2) ambulatory and 12-lead electrocardiograms. The information consisted of digital and analog waveform information, static images, and 30 fps video. The system provided rapid data transmission to UNMC over a T-1 line. The system utilized a compression technology which did not degrade the interpretation quality of the data. This system has increased the availability of advanced cardiac diagnostic services to general medical practitioners in a rural hospital. In addition, the system has significantly reduced the time and cost to transmit vital cardiac diagnostic information, thus improving the quality of care received by rural patients.


    Little, Todd D; Wang, Eugene W; Gorrall, Britt K


    This chapter selectively reviews the evolution of quantitative practices in the field of developmental methodology. The chapter begins with an overview of the past in developmental methodology, discussing the implementation and dissemination of latent variable modeling and, in particular, longitudinal structural equation modeling. It then turns to the present state of developmental methodology, highlighting current methodological advances in the field. Additionally, this section summarizes ample quantitative resources, ranging from key quantitative methods journal articles to the various quantitative methods training programs and institutes. The chapter concludes with the future of developmental methodology and puts forth seven future innovations in the field. The innovations discussed span the topics of measurement, modeling, temporal design, and planned missing data designs. Lastly, the chapter closes with a brief overview of advanced modeling techniques such as continuous time models, state space models, and the application of Bayesian estimation in the field of developmental methodology. © 2017 The Society for Research in Child Development, Inc.

  3. Advances in the prevention of Alzheimer's disease and dementia.

    Solomon, A; Mangialasche, F; Richard, E; Andrieu, S; Bennett, D A; Breteler, M; Fratiglioni, L; Hooshmand, B; Khachaturian, A S; Schneider, L S; Skoog, I; Kivipelto, M


    Definitions and diagnostic criteria for all medical conditions are regularly subjected to reviews and revisions as knowledge advances. In the field of Alzheimer's disease (AD) research, it has taken almost three decades for diagnostic nomenclature to undergo major re-examination. The shift towards presymptomatic and pre-dementia stages of AD has brought prevention and treatment trials much closer to each other than before. Here we discuss: (i) the impact of diagnostic reliability on the possibilities for developing preventive strategies for AD; (ii) the scientific evidence to support moving from observation to action; (iii) ongoing intervention studies; and (iv) the methodological issues and prospects for balancing strategies for high-risk individuals with those for broad population-based prevention. The associations between neuropathology and cognition are still not entirely clear. In addition, the risk factors for AD dementia and the neuropathological hallmarks of AD may not necessarily be the same. Cognitive impairment has a clearer clinical significance and should therefore remain the main focus of prevention. Risk/protective factors for dementia/AD need to be studied from a life-course perspective. New approaches in prevention trials include enrichment strategies based on genetic risk factors or beta-amyloid biomarkers (at least four ongoing pharmacological trials), and multidomain interventions simultaneously targeting various vascular and lifestyle-related risk factors (at least three ongoing trials). Experience from prevention programmes in other chronic diseases can provide additional methodological improvements. Building infrastructures for international collaborations is necessary for managing the worldwide public health problem of AD and dementia. The International Database on Aging and Dementia (IDAD) and the European Dementia Prevention Initiative (EDPI) are examples of ongoing international efforts aiming to improve the methodology of preventive

  4. Canine Hip Dysplasia: Diagnostic Imaging.

    Butler, J Ryan; Gambino, Jennifer


    Diagnostic imaging is the principal method used to screen for and diagnose hip dysplasia in the canine patient. Multiple techniques are available, each having advantages, disadvantages, and limitations. Hip-extended radiography is the most used method and is best used as a screening tool and for assessment for osteoarthritis. Distraction radiographic methods such as the PennHip method allow for improved detection of laxity and improved ability to predict future osteoarthritis development. More advanced techniques such as MRI, although expensive and not widely available, may improve patient screening and allow for improved assessment of cartilage health. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. RTDP方法在大型先进压水堆热工设计中的应用初步研究%Preliminary Research on RTDP Methodology for Advanced LPP Thermal-hydraulic Design

    杨萍; 贾红轶; 王喆


    Departure from nucleate boiling (DNB) design basis is one of the most important basis for reactor core thermal-hydraulic design.In order to evaluate whether the DNB design basis meets the demand of thermal-hydraulic design,the departure from nucleate boiling ratio (DNBR) design limit should be determined first.The RTDP methodology was described detailedly,in which the uncertainties of operating parameters and nuclear design parameters were statistically combined.Then the RTDP methodology and a reactor subchannel code were applied to calculate the DNBR design limit and quality limit for LPP.The conclusions were presented to provide the key acceptable criterion for DNBR design basis.%偏离泡核沸腾(DNB)设计基准是反应堆热工水力设计中的重要基准之一,为评价该设计基准是否满足热工水力设计要求,首先需确定堆芯偏离泡核沸腾比(DNBR)设计限值.本工作详细论述了使用统计学方法确定运行参数及核设计参数等不确定性的RTDP原理,并应用该方法和堆芯子通道分析程序对大型先进压水堆DNBR设计限值及含汽率限值进行计算并给出结论,为DNBR设计基准的验证提供了关键判据.

  6. Nanotechnology based diagnostics for neurological disorders

    Kurek, Nicholas S.; Chandra, Sathees B., E-mail: [Department of Biological, Chemical and Physical Sciences, Roosevelt University, Chicago, IL (United States)


    Nanotechnology involves probing and manipulating matter at the molecular level. Nanotechnology based molecular diagnostics have the potential to alleviate the suffering caused by many diseases, including neurological disorders, due to the unique properties of nanomaterials. Most neurological illnesses are multifactorial conditions and many of these are also classified as neurobehavioral disorders. Alzheimer's disease, Parkinson's disease, Huntington disease, cerebral ischemia, epilepsy, schizophrenia and autism spectrum disorders like Rett syndrome are some examples of neurological disorders that could be better treated, diagnosed, prevented and possibly cured using nanotechnology. In order to improve the quality of life for disease afflicted people, a wide range of nanomaterials that include gold and silica nanoparticles, quantum dots and DNA along with countless other forms of nanotechnology have been investigated regarding their usefulness in advancing molecular diagnostics. Other small scaled materials like viruses and proteins also have potential for use as molecular diagnostic tools. Information obtained from nanotechnology based diagnostics can be stored and manipulated using bioinformatics software. More advanced nanotechnology based diagnostic procedures for the acquisition of even greater proteomic and genomic knowledge can then be developed along with better ways to fight various diseases. Nanotechnology also has numerous applications besides those related to biotechnology and medicine. In this article, we will discuss and analyze many novel nanotechnology based diagnostic techniques at our disposal today. (author)

  7. T-4G Methodology: Undergraduate Pilot Training T-37 Phase.

    Woodruff, Robert R.; And Others

    The report's brief introduction describes the application of T-4G methodology to the T-37 instrument phase of undergraduate pilot training. The methodology is characterized by instruction in trainers, proficiency advancement, a highly structured syllabus, the training manager concept, early exposure to instrument training, and hands-on training.…

  8. Modeling, methodologies and tools for molecular and nano-scale communications modeling, methodologies and tools

    Nakano, Tadashi; Moore, Michael


    (Preliminary) The book presents the state of art in the emerging field of molecular and nanoscale communication. It gives special attention to fundamental models, and advanced methodologies and tools used in the field. It covers a wide range of applications, e.g. nanomedicine, nanorobot communication, bioremediation and environmental managements. It addresses advanced graduate students, academics and professionals working at the forefront in their fields and at the interfaces between different areas of research, such as engineering, computer science, biology and nanotechnology.

  9. Validation Tools and Methods for Diagnostic Systems Project

    National Aeronautics and Space Administration — The potential benefits of advanced algorithms for diagnostics and prognostics, inner-loop control, and other flight critical systems have been demonstrated in a...

  10. A Verification and Validation Tool for Diagnostic Systems Project

    National Aeronautics and Space Administration — Advanced diagnostic systems have the potential to improve safety, increase availability, and reduce maintenance costs in aerospace vehicle and a variety of other...

  11. [Advanced imaging methods as a basis for more reliable classification and better treatment for patients with depressive symptoms--an example for conceptual change in the psychiatric diagnostic method].

    Vishne, Tali


    The current editorial study focuses on the idea of using advanced imaging methods in order to better classify and treat patients with depression and other psychiatric illnesses. The editorial is based on the review of Heymann and Bonne, published in this issue of the journal, showing differences between bi-polar and uni-polar depression using functional neuroimaging methods. This example, although not applicable yet in clinical practice, is the basis for future advances in psychiatric classification, together with clinical subtyping, and more biological markers, including genetic profiling.

  12. Enterprise services and object-oriented methodologies

    Milan Mišovič


    Full Text Available In this paper we study the possibility of modifying the conventional, advanced object-oriented methodology for software development of enterprise information systems on an enterprise services platform. The presented solution is preceded with the draft of the formal description of the business process logic and its service solutions. In the design for the introduction of business services there is used the so-called native solution that is very close to the thinking of corporate management. Adjustment of the classic, advanced object-oriented methodology is oriented on its cardinal development phases INSEPTION and ELABORATION. In these two phases important descriptions of relevant information modeling results are formed for the following CONSTRUCTION phase and TRANSITION phase. Editing, however, is methodological, and meta-documented with an example of a transparent graphical description of business services and a logical architecture of the target software.In other words, it means that this contribution provides small software companies with valuable knowledge for the creation of their own development methodologies on a platform of enterprise services. The purpose of this paper is to contribute to the formation of implementing development methodologies, which absorb current knowledge disciplines of Software and Information Engineering.

  13. Advanced urology nursing practice.

    Crowe, Helen


    Urology nursing has developed as a specialty over the past few decades in response to several factors, workload demands being a prime reason. Nurses are taking on additional roles and activities including procedures such as cystoscopy and prostate biopsy, and running nurse-led clinics for a variety of urological conditions. Audits of advanced urological nursing practice have shown this care to be of a high standard and investigative procedures performed by these nurses match the diagnostic quality of existing services. Professional urological nursing organizations support the professional needs of these nurses, but the provision of education and training for advanced practice activities remains an unaddressed need. A range of confusing advanced urology nursing titles exists, and uncertainty regarding the roles and scope of practice for these nurses remains a concern. Acceptance and support from medical colleagues is required for the success of advanced urological nursing practice, but opinions on these roles remain divided.

  14. Changes in clinical trials methodology over time: a systematic review of six decades of research in psychopharmacology.

    André R Brunoni

    Full Text Available BACKGROUND: There have been many changes in clinical trials methodology since the introduction of lithium and the beginning of the modern era of psychopharmacology in 1949. The nature and importance of these changes have not been fully addressed to date. As methodological flaws in trials can lead to false-negative or false-positive results, the objective of our study was to evaluate the impact of methodological changes in psychopharmacology clinical research over the past 60 years. METHODOLOGY/PRINCIPAL FINDINGS: We performed a systematic review from 1949 to 2009 on MEDLINE and Web of Science electronic databases, and a hand search of high impact journals on studies of seven major drugs (chlorpromazine, clozapine, risperidone, lithium, fluoxetine and lamotrigine. All controlled studies published 100 months after the first trial were included. Ninety-one studies met our inclusion criteria. We analyzed the major changes in abstract reporting, study design, participants' assessment and enrollment, methodology and statistical analysis. Our results showed that the methodology of psychiatric clinical trials changed substantially, with quality gains in abstract reporting, results reporting, and statistical methodology. Recent trials use more informed consent, periods of washout, intention-to-treat approach and parametric tests. Placebo use remains high and unchanged over time. CONCLUSIONS/SIGNIFICANCE: Clinical trial quality of psychopharmacological studies has changed significantly in most of the aspects we analyzed. There was significant improvement in quality reporting and internal validity. These changes have increased study efficiency; however, there is room for improvement in some aspects such as rating scales, diagnostic criteria and better trial reporting. Therefore, despite the advancements observed, there are still several areas that can be improved in psychopharmacology clinical trials.

  15. Innovative diagnostics and treatment nanorobotics and stem cells

    Jadczyk, Tomasz; Mishra, Sachin; Jędrzejek, Marek; Bołoz, Marta; Padmanabhan, Parasuraman; Wojakowski, Wojciech; Stárek, Zdeněk; Martel, Sylvain; Gulyás, Balázs


    This book focuses on nanorobotic agents and stem cells for biomedical applications.It is intended for researchers and clinicians interested in innovative diagnostic and therapeutic strategies based on nanorobots and stem cells.It presents current advances in the field of molecular machines, which could be applied to generate novel therapeutic-diagnostic systems.

  16. Active and Passive Diagnostic Signatures of Special Nuclear Materials

    Myers, William L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Karpius, Peter Joseph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Myers, Steven Charles [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    An overview will be given discussing signatures associated with special nuclear materials acquired using both active and passive diagnostic techniques. Examples of how technology advancements have helped improve diagnostic capabilities to meet the challenges of today’s applications will be discussed.

  17. Health Economic Assessment: A Methodological Primer

    Steven Simoens


    Full Text Available This review article aims to provide an introduction to the methodology of health economic assessment of a health technology. Attention is paid to defining the fundamental concepts and terms that are relevant to health economic assessments. The article describes the methodology underlying a cost study (identification, measurement and valuation of resource use, calculation of costs, an economic evaluation (type of economic evaluation, the cost-effectiveness plane, trial- and model-based economic evaluation, discounting, sensitivity analysis, incremental analysis, and a budget impact analysis. Key references are provided for those readers who wish a more advanced understanding of health economic assessments.

  18. Advances in hematology analyzers.

    DeNicola, Dennis B


    The complete blood count is one of the basic building blocks of the minimum database in veterinary medicine. Over the past 20 years, there has been a tremendous advancement in the technology of hematology analyzers and their availability to the general practitioner. There are 4 basic methodologies that can be used to generate data for a complete blood count: manual methods, quantitative buffy coat analysis, automated impedance analysis, and flow cytometric analysis. This article will review the principles of these methodologies, discuss some of their advantages and disadvantages, and describe some of the hematology analyzers that are available for the in-house veterinary laboratory.

  19. Design Methodology - Design Synthesis

    Andreasen, Mogens Myrup


    ABSTRACT Design Methodology shall be seen as our understanding of how to design; it is an early (emerging late 60ies) and original articulation of teachable and learnable methodics. The insight is based upon two sources: the nature of the designed artefacts and the nature of human designing. Today...... Design Methodology is part of our practice and our knowledge about designing, and it has been strongly supported by the establishing and work of a design research community. The aim of this article is to broaden the reader¿s view of designing and Design Methodology. This is done by sketching...... the development of Design Methodology through time and sketching some important approaches and methods. The development is mainly forced by changing industrial condition, by the growth of IT support for designing, but also by the growth of insight into designing created by design researchers....

  20. Challenges in diagnostic accuracy studies in primary care : the fecal calprotectin example

    Holtman, Gea A.; Lisman-van Leeuwen, Yvonne; Kollen, Boudewijn J.; Escher, Johanna C.; Kindermann, Angelika; van Rheenen, Patrick F.; Berger, Marjolein Y.


    Background: Low disease prevalence and lack of uniform reference standards in primary care induce methodological challenges for investigating the diagnostic accuracy of a test. We present a study design that copes with these methodological challenges and discuss the methodological implications of ou

  1. Challenges in diagnostic accuracy studies in primary care: The fecal calprotectin example

    G.A. Holtman (Gea A); Y. van Leeuwen (Yvonne); B.J. Kollen (Boudewijn ); J.C. Escher (Johanna); A. Kindermann; P.F.V. Rheenen (Patrick F Van); M.Y. Berger (Marjolein)


    textabstractAbstract. Background: Low disease prevalence and lack of uniform reference standards in primary care induce methodological challenges for investigating the diagnostic accuracy of a test. We present a study design that copes with these methodological challenges and discuss the methodologi

  2. Nanoplasmonics advanced device applications

    Chon, James W M


    Focusing on control and manipulation of plasmons at nanometer dimensions, nanoplasmonics combines the strength of electronics and photonics, and is predicted to replace existing integrated circuits and photonic devices. It is one of the fastest growing fields of science, with applications in telecommunication, consumer electronics, data storage, medical diagnostics, and energy.Nanoplasmonics: Advanced Device Applications provides a scientific and technological background of a particular nanoplasmonic application and outlines the progress and challenges of the application. It reviews the latest

  3. Transparent Guideline Methodology Needed

    Lidal, Ingeborg; Norén, Camilla; Mäkelä, Marjukka


    Group.2 Similar criteria for guideline quality have been suggested elsewhere.3 Our conclusion was that this much needed guideline is currently unclear about several aspects of the methodology used in developing the recommendations. This means potential users cannot be certain that the recommendations...... are based on best currently available evidence. Our concerns are in two main categories: the rigor of development, including methodology of searching, evaluating, and combining the evidence; and editorial independence, including funding and possible conflicts of interest....

  4. Diagnostics for PLX-alpha

    Gilmore, Mark; Hsu, Scott


    The goal of the Plasma Liner eXperiment PLX-alpha at Los Alamos National Laboratory is to establish the viability of creating a spherically imploding plasma liner for MIF and HED applications, using a spherical array of supersonic plasma jets launched by innovative contoured-gap coaxial plasma guns. PLX- α experiments will focus in particular on establishing the ram pressure and uniformity scalings of partial and fully spherical plasma liners. In order to characterize these parameters experimentally, a suite of diagnostics is planned, including multi-camera fast imaging, a 16-channel visible interferometer (upgraded from 8 channels) with reconfigurable, fiber-coupled front end, and visible and VUV high-resolution and survey spectroscopy. Tomographic reconstruction and data fusion techniques will be used in conjunction with interferometry, imaging, and synthetic diagnostics from modeling to characterize liner uniformity in 3D. Diagnostic and data analysis design, implementation, and status will be presented. Supported by the Advanced Research Projects Agency - Energy - U.S. Department of Energy.


    Łukasz KONIECZNY


    Full Text Available The article presents the methodology of Common Rail injector diagnostic, regeneration and regulation with use of professional test stands. The EPS 815 machine can be used to test and repair all BOSCH injectors fully satisfying the producer requirements and standards. The article describes an example injector diagnosis with use of such test stand and additionally presents appropriate injector regeneration and encoding techniques

  6. Diagnostics of the Enterprise Export Potential

    Skrynkovskyy Ruslan M.; Klyuvak Oksana V.; Protsevyat Oksana S.


    The aim of the article is to form and develop theoretical and methodological foundations for diagnostics of the enterprise export potential, which should be understood as a process of identification, analysis and assessment of the level of potential possibility and readiness of the enterprise to implement export activities taking into account the impact of interrelated internal variables (goals, technology, structure, tasks, educational and professional potential of the staf...

  7. Mapping 'Chinese media studies': A diagnostic survey

    Hong, Jeesoon


    This article views Chinese media as a complex web of diverse academic disciplines and political perspectives, and provides a diagnostic survey of the various disciplines that deal with Chinese media. By clarifying and comparing the methodological characteristics of these academic disciplines, it attempts to prepare for interdisciplinary dialogue. It will pose questions such as what kinds of disciplines have become involved in the studies of Chinese media; what are the main focuses and the met...

  8. Re-thinking diagnostic classification of the dysarthrias: a developmental perspective.

    Morgan, A T; Liégeois, F


    Acquired childhood dysarthria (ACD) receives little attention in the research literature in contrast with the adult correlate of the disorder. Speech language pathologists working in this field find diagnosis and management challenging, arguably because there is no child-based dysarthria diagnostic classification. Clinicians are either dependent upon developmental speech models that are not specific to dysarthria and that ignore the neural basis of the disorder, or on adult-based neurobehavioural classification systems. Here we consider the necessary elements for developing a clinically useful and empirically driven diagnostic classification system for ACD. The paper is divided into 2 parts. First, we question whether an adult diagnostic model can be validly applied to children. Second, we propose a methodological approach to develop a classification system for ACD. Specifically, we propose that advancing knowledge in neurobehavioural correlations of ACD is contingent upon large-scale studies, likely requiring international collaboration, which pool brain and speech outcome data. Ideally, researchers across centres would apply standard protocols to: (1) characterize speech behaviour, and (2) brain structure, function and connectivity. When enough data is available to achieve statistical power, analysis could determine subgroups of dysarthria defined by speech behaviour. The commonalities of neural profiles of subgroups could then be examined to create an empirically driven theory of brain-behaviour relationships in ACD to underpin the classification system. Clinical diagnosis for children with ACD will remain limited until such data become available.

  9. Diagnostic Development on NSTX

    A.L. Roquemore; D. Johnson; R. Kaita; et al


    Diagnostics are described which are currently installed or under active development for the newly commissioned NSTX device. The low aspect ratio (R/a less than or equal to 1.3) and low toroidal field (0.1-0.3T) used in this device dictate adaptations in many standard diagnostic techniques. Technical summaries of each diagnostic are given, and adaptations, where significant, are highlighted.


    R. A. Barto


    Full Text Available Background: Endometriosis is one of the major problems in current gynecology due to steady increase of its incidence, involvement of young females, high frequency of infertility and difficulties with diagnostics and treatment. Confirmation of diagnosis of advanced endometriosis is still within the competence of research centers and big federal treatment establishments.Aim: To improve ultrasound diagnostics and to develop an algorithm of assessment in retrocervical endometriosis.Materials and methods: Seventy two females were assessed laparoscopically due to a gynecology disorder or infertility. Based on intraoperational data and results of pathomorphological assessments, two groups were formed: group 1 (control group, n = 26 comprised patients in reproductive age who had been admitted for elective surgery due to a gynecological disorder. Group 2 (main group, n = 46 included patients with various types of endometriosis. Patients from group 2 were divided into 3 subgroups: 2а (n = 17 – with superficial forms of external genital endometriosis; 2b (n = 18 – with endometrioid cysts; 2c (n = 11 – with deep infiltrative types of endometriosis.Results: Patients with superficial external genital endometriosis were characterized by positive symptom of “folding” (“freezing” of posterior uterine surface and of the walls of adjacent intestine. In endometriosis of posterior surface of cervix uteri, the diagnosis made by an ultrasound assessmentin 100% matched the diagnosis set during surgery, whereas if sacrouterine ligaments were involved, the diagnostic match was only 3%. In the group of patients with endometrioid cysts, in most of cases the cysts had specific ultrasound signs; coincidence of an ultrasound and a morphological diagnosis was seen in 98% of cases. Most cases of deep infiltrative endometriosis showed involvement of sacrouterine ligaments (72% and of parametrium (81%. There was a positive folding sign and a “Indian headdress

  11. Advances in Methodologies for Detection and Identiifcation of theS-nitrosylat-ed Proteins%蛋白质亚硝基化检测和鉴定方法的研究进展

    汪达丽; 张双双; 刘建


    Similar to phosphorylation,S-nitrosylation is a newly identiifed protein modiifcation in which nitric oxide (NO) moiety covalently attached to thiol group.S-nitrosylation is a reversible process and it can result in the alteration of protein functions in guanosine 3′, 5′-cyclic phosphate (cGMP) independent manner. It has been shown thatS-nitrosylation plays important regulatory roles in various physiological and pathological processes from growth and development to biotic and abiotic stress responses. The research publications in this ifeld have grown exponentially since its discovery. Up to date, numerous review articles have been published on howS-ni-trosylation exerts its inlfuences on protein functions. However, review articles that summarize the detection of S-nitrosylated proteins and the identiifcation of the sites of this modiifcation are rare. Thus, we reviewed the de-velopment, evolution and current status of the methodologies for proteinS-nitrosylation studies.%蛋白的亚硝基化是近期发现的一种类似于磷酸化、可逆的、不依赖于环磷酸鸟苷(cGMP)的一氧化氮修饰和调节蛋白功能的新途径。一经发现,有关亚硝基化的研究呈指数级递增。亚硝基化参与从生长发育到抗病、抗逆等多个生理和病理过程。已有大量综述对亚硝基化调控蛋白功能从而影响某一生理生化及病理过程进行了总结。但迄今为止,对检测蛋白亚硝基化的手段和鉴定亚硝基化位点的方法进行总结的文献综述仍屈指可数。据此,我们对蛋白亚硝基化检测手段的发明、改进提高、亚硝基化位点的结构特点以及亚硝基化位点预测软件的开发等进行综述,旨在为该领域内科研工作者提供方便。


    Bari R. A.; Whitlock, J.; Therios, I.U.; Peterson, P.F.


    We summarize the technical progress and accomplishments on the evaluation methodology for proliferation resistance and physical protection (PR and PP) of Generation IV nuclear energy systems. We intend the results of the evaluations performed with the methodology for three types of users: system designers, program policy makers, and external stakeholders. The PR and PP Working Group developed the methodology through a series of demonstration and case studies. Over the past few years various national and international groups have applied the methodology to nuclear energy system designs as well as to developing approaches to advanced safeguards.

  13. Regional Shelter Analysis Methodology

    Dillon, Michael B. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dennison, Deborah [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kane, Jave [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Walker, Hoyt [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Miller, Paul [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)


    The fallout from a nuclear explosion has the potential to injure or kill 100,000 or more people through exposure to external gamma (fallout) radiation. Existing buildings can reduce radiation exposure by placing material between fallout particles and exposed people. Lawrence Livermore National Laboratory was tasked with developing an operationally feasible methodology that could improve fallout casualty estimates. The methodology, called a Regional Shelter Analysis, combines the fallout protection that existing buildings provide civilian populations with the distribution of people in various locations. The Regional Shelter Analysis method allows the consideration of (a) multiple building types and locations within buildings, (b) country specific estimates, (c) population posture (e.g., unwarned vs. minimally warned), and (d) the time of day (e.g., night vs. day). The protection estimates can be combined with fallout predictions (or measurements) to (a) provide a more accurate assessment of exposure and injury and (b) evaluate the effectiveness of various casualty mitigation strategies. This report describes the Regional Shelter Analysis methodology, highlights key operational aspects (including demonstrating that the methodology is compatible with current tools), illustrates how to implement the methodology, and provides suggestions for future work.

  14. Methodology and algorithms for railway crew management

    Goncalves, R.; Gomide, F. [State Univ. of Campinas, SP (Brazil). Faculty of Electrical and Computer Engineering; Lagrimante, R. [MRS Logistica S.A, Juiz de Fora, MG (Brazil)


    Crew management problems are highly important for many transportation systems such as airlines, railways and public bus transportation. Despite recent advances, scheduling methodologies and decision support systems still need improvement, especially their computational efficiency, practical feasibility and use. This paper briefly overview classic crew management approaches. It discusses various practical issues concerning classic methods and suggests a new approach and algorithms. Computational results and experience with actual data and real world situations are also reported. (orig.)

  15. A Functional HAZOP Methodology

    Liin, Netta; Lind, Morten; Jensen, Niels


    A HAZOP methodology is presented where a functional plant model assists in a goal oriented decomposition of the plant purpose into the means of achieving the purpose. This approach leads to nodes with simple functions from which the selection of process and deviation variables follow directly....... The functional HAZOP methodology lends itself directly for implementation into a computer aided reasoning tool to perform root cause and consequence analysis. Such a tool can facilitate finding causes and/or consequences far away from the site of the deviation. A functional HAZOP assistant is proposed...... and investigated in a HAZOP study of an industrial scale Indirect Vapor Recompression Distillation pilot Plant (IVaRDiP) at DTU-Chemical and Biochemical Engineering. The study shows that the functional HAZOP methodology provides a very efficient paradigm for facilitating HAZOP studies and for enabling reasoning...

  16. Advanced practice physiotherapy in patients with musculoskeletal disorders: a systematic review.

    Desmeules, François; Roy, Jean-Sébastien; MacDermid, Joy C; Champagne, François; Hinse, Odette; Woodhouse, Linda June


    The convergence of rising health care costs and physician shortages have made health care transformation a priority in many countries resulting in the emergence of new models of care that often involve the extension of the scope of practice for allied health professionals. Physiotherapists in advanced practice/extended scope roles have emerged as key providers in such new models, especially in settings providing services to patients with musculoskeletal disorders. However, evidence of the systematic evaluation of advance physiotherapy practice (APP) models of care is scarce. A systematic review was done to update the evaluation of physiotherapists in APP roles in the management of patients with musculoskeletal disorders. Structured literature search was conducted in 3 databases (Medline, Cinahl and Embase) for articles published between 1980 and 2011. Included studies needed to present original quantitative data that addressed the impact or the effect of APP care. A total of 16 studies met all inclusion criteria and were included. Pairs of raters used four structured quality appraisal methodological tools depending on design of studies to analyse included studies. Included studies varied in designs and objectives and could be categorized in four areas: diagnostic agreement or accuracy compared to medical providers, treatment effectiveness, economic efficiency or patient satisfaction. There was a wide range in the quality of studies (from 25% to 93%), with only 43% of papers reaching or exceeding a score of 70% on the methodological quality rating scales. Their findings are however consistent and suggest that APP care may be as (or more) beneficial than usual care by physicians for patients with musculoskeletal disorders, in terms of diagnostic accuracy, treatment effectiveness, use of healthcare resources, economic costs and patient satisfaction. The emerging evidence suggests that physiotherapists in APP roles provide equal or better usual care in comparison to

  17. Emerging horizons of salivary diagnostics for periodontal disease.

    Fuentes, L; Yakob, M; Wong, D T W


    The field of salivary diagnostics to allow risk determination for periodontal diseases is advancing. New technologies in proteomics, genomics and nanotechnologies have continued the discovery of discriminatory periodontal disease biomarkers. This review briefly overviews biomarker studies that have been completed in saliva for the detection of periodontal disease since 2010. Disease specific biomarkers could be used in risk determination, treatment planning and disease progression. Currently, diagnostic tests are commercially available, and the development of point-of-care tests is expanding. Even though challenges remain, salivary diagnostics for periodontal disease is promising and could facilitate the diagnostics and treatment in a clinical practice by dental practitioners.

  18. Computer-assisted Diagnostic Checklist in Clinical Neurology.

    Finelli, Pasquale F; McCabe, Andrew L


    Considering computers are more efficient at processing large amounts of information than the human brain, speaks to the need to explore more intelligent computer-assisted diagnostic approaches. Two diagnostic checklist programs, one for single key term entry (NeurologyINDEX), and another, with more advanced algorithms to process multiple key terms and perform additional functions (NeurologicDx) are discussed. Both programs are internet based, access the same database, and are designed to generate diagnostic checklists and disease profiles accessible with hand-held or other computer device. The development of systems that use "smart algorithms" to generate valid diagnostic checklists is the goal.

  19. Advances and Applications on Methodology of 16S rRNA Sequencing in Gut Microbiota Analysis%16S rRNA测序技术在肠道微生物中的应用研究进展

    李东萍; 郭明璋; 许文涛


    16S rRNA sequencing is one of the high-throughput-sequencing-based methods used in gut microbiota analysis. Almost all the bacterial species in gut microbiota can be quantified through 16S rRNA sequencing, which has made this method into the mainstream. Two issues are very important in the application of 16S rRNA sequencing:sequencing strategy and bioinformatic analysis. In this review, three aspects of the sequencing strategy, including sequencing platform, sequencing region, and data size were discussed. While on bioinformatic analysis, the advance in sequences cluster and annotation, microbiota structure analysis, key taxa screening and functional analysis were reviewed here.%16S rRNA测序是高通量测序依赖的肠道微生物研究方法之一,该方法可以对肠道微生物中的所有菌种进行精确定量,因此正逐渐成为研究肠道微生物菌种丰度变化的主流。肠道微生物16S rRNA测序的应用过程中有两个问题至关重要,一是如何根据需要选择测序方案;二是面对高通量测序得到的海量数据,如何进行生物信息学分析,以得到具有生物学意义的结果。从测序平台、测序片段、测序数据量的选择3个方面讨论了如何选择测序方案,并从序列聚类与注释、群落结构分析、关键分类单位的筛选与功能分析等方面对目前常用的生物信息学分析手段进行综述。

  20. Changing methodologies in TESOL

    Spiro, Jane


    Covering core topics from vocabulary and grammar to teaching, writing speaking and listening, this textbook shows you how to link research to practice in TESOL methodology. It emphasises how current understandings have impacted on the language classroom worldwide and investigates the meaning of 'methods' and 'methodology' and the importance of these for the teacher: as well as the underlying assumptions and beliefs teachers bring to bear in their practice. By introducing you to language teaching approaches, you will explore the way these are influenced by developments in our understanding of l

  1. Methodology for research I.

    Garg, Rakesh


    The conduct of research requires a systematic approach involving diligent planning and its execution as planned. It comprises various essential predefined components such as aims, population, conduct/technique, outcome and statistical considerations. These need to be objective, reliable and in a repeatable format. Hence, the understanding of the basic aspects of methodology is essential for any researcher. This is a narrative review and focuses on various aspects of the methodology for conduct of a clinical research. The relevant keywords were used for literature search from various databases and from bibliographies of the articles.

  2. Methodology and tools of enterprise innovativeness evaluation

    L.O. Ligonenko


    Full Text Available The aim of the article. The aim of the article is to analyse critically the existing approaches to enterprise innovativeness evaluation, these approaches additions and organizing in order to justify the research methodology and develop tools for integral indicator evaluation (diagnosis. The results of the analysis. Innovativeness of the enterprise is an important social and economic characteristics, foundation and intention of the enterprise theory and a contemporary paradigm of management. It is a system multifaceted complex concept, which describes an enterprise ability to provide innovative development as a result of from management efforts, and to transform innovative potential after innovative measures. Innovativeness of an enterprise can and should be the object of management. Making evaluation (diagnostics and establishing monitoring of enterprise innovativeness o are important practical tasks. They are the basis for adequate decision-making and a necessary precondition for successful innovation and technological development. Innovation as an indicator of evaluation relates to complex of enterprise integrated characteristics such as competitiveness, investment attractiveness, viability, creditworthiness and so on. The level of innovation is an integral valuation indicator, which characterizes the stage (extent of enterprise innovativeness. A critical review of available scientific proposals for innovative parameters evaluation proved the need for the formation of the system of enterprise innovativeness analytical indicators. There are two levels of indicators: 1 indicators of public (express and 2 indicators of internal (fundamental innovativeness evaluation. Calculation of indicators of the first group is based on operating statistical reporting forms of Ukraine and enterprises specialized monitoring. These indicators are intended for an innovativeness public indicator evaluation. Indicators of the second group serve as an information

  3. Diagnostics for FIRE: A status report

    Young, Kenneth M.


    The mission for the proposed fusion ignition research experiment (FIRE) device is to "attain, explore, understand and optimize fusion-dominated plasmas." Operation at Q⩾5, for 20 s with a fusion power output of ˜150 MW is the major goal. Attaining this mission sets demands for plasma measurement which are at least as comprehensive as on present tokamaks, with the additional capabilities needed for control of the plasma and for understanding the effects of the alpha-particles. Because of the planned operation in advanced tokamak scenarios, with steep transport barriers, the diagnostic instrumentation must be able to provide fine spatial and temporal resolution. It must also be able to withstand the impact of the intense neutron and gamma irradiation. There are practical engineering issues of minimizing radiation streaming while providing essential diagnostic access to the plasma. Many components will operate close to the first wall, e.g., ceramics and mineral insulated cable for magnetic diagnostics and mirrors for optical diagnostics; these components must be selected and mounted so that they will operate and survive in fluxes which require special material selection. The measurement requirements have been assessed so that the diagnostics for the FIRE device can be defined. Clearly, a better set of diagnostics of alpha-particles than that available for TFTR is essential, since the alpha-particles provide the dominant sources of heating and of instability-drive in the plasma.

  4. Diagnostics of Nanodusty Plasma

    Greiner, Franko; Groth, Sebastian; Tadsen, Bejamin; Piel, Alexander


    The diagnostic of nanodusty plasmas, i.e. plasmas including nano-sized dust particles, is a challenging task. For both, the diagnostic of the nanodusty plasma itself, and the in-situ diagnostic of the nanoparticles, no standard diagnostic exist. Nanodust particle size and density can be estimated using light scattering techniques, namely kinetic Mie ellipsometry and extinction measurements. The charge of the nanoparticles can be estimated from the analysis of dust density waves (DDW). Parameters like the electron density, which give information about the plasma itself, may be deduced from the DDW analysis. We present detailed investigations on nanodust in a reactive Argon-Acetylene plasma created in an rf-driven parallel plate reactor at low pressure using the above mentioned portfolio of diagnostic. Funded by DFG under contract SFB TR-24/A2.

  5. [Systematic review of diagnostic tests accuracy: a narrative review].

    de Oliveira, Glória Maria; Camargo, Fábio Trinca; Gonçalves, Eduardo Costa; Duarte, Carlos Vinicius Nascimento; Guimarães, Carlos Alberto


    The aim of this study is to perform a narrative review of systematic reviews of diagnostic tests accuracy. We undertook a search using The Cochrane Methodology Reviews (Cochrane Reviews of Diagnostic Test Accuracy), Medline and LILACS up to October 2009. Reference lists of included studies were also hand searched. The following search strategy was constructed by using a combination of subject headings and text words: 1. Cochrane Methodology Reviews: accuracy study "Methodology" 2. In Pubmed "Meta-Analysis" [Publication Type] AND "Evidence-Based Medicine" [Mesh]) AND "Sensitivity and Specificity" [Mesh] 3. LILACS (revisao sistematica) or "literatura de REVISAO como assunto" [Descritor de assunto] and (sistematica) or "SISTEMATICA" [Descritor de assunto] and (acuracia) or "SENSIBILIDADE e especificidade" [Descritor de assunto]. In summary, the methodological planning and preparation of systematic reviews of therapeutic interventions are prior to that used in systematic reviews of diagnostic tests accuracy. There are more sources of heterogeneity in design of diagnostic test studies, which impair the synthesis - meta-analysis - of the results. To work around this problem, there are currently uniform requirements for diagnostic test manuscripts submitted to leading biomedical journals.

  6. The methodological cat

    Marin Dinu


    Full Text Available Economics understands action as having the connotation of here and now, the proof being that it excessively uses, for explicative purposes, two limitations of sense: space is seen as the place with a private destination (through the cognitive dissonance of methodological individualism, and time is seen as the short term (through the dystopia of rational markets.

  7. Video: Modalities and Methodologies

    Hadfield, Mark; Haw, Kaye


    In this article, we set out to explore what we describe as the use of video in various modalities. For us, modality is a synthesizing construct that draws together and differentiates between the notion of "video" both as a method and as a methodology. It encompasses the use of the term video as both product and process, and as a data collection…

  8. Diagnostics of the Enterprise Export Potential

    Skrynkovskyy Ruslan M.


    Full Text Available The aim of the article is to form and develop theoretical and methodological foundations for diagnostics of the enterprise export potential, which should be understood as a process of identification, analysis and assessment of the level of potential possibility and readiness of the enterprise to implement export activities taking into account the impact of interrelated internal variables (goals, technology, structure, tasks, educational and professional potential of the staff and factors of the enterprise external environment (customers, competitors, suppliers, intermediaries, contact audience, etc. in order to ensure a qualitatively new level of its development and formation of its prospects. It is determined that the key business indicators of the system for diagnostics of enterprise export potential are: the level of enterprises competitiveness in the international (global market; the level of competitiveness of enterprise products; the level of competitiveness of enterprise export products; the level of enterprise resource opportunities; the level of enterprise export performance. Prospects for further research in this direction are to develop a classification (specifically detailed list of objectives of the enterprise diagnostics by the level of detail (element, partial, complex, taking into account diagnostics of export potential of the enterprise as part of diagnostic objective.

  9. 38{sup th} European Society of Neuroradiology. Diagnostic and interventional



    The volume contains abstracts of the 38th ESNR annual meeting covering the following topics: advanced tumor imaging, advanced tumor treatment, intracranial aneurisms, spine tumors and metastasis, spondilodiscitis update, interventional neuroradiology, dementia and movement disorders, intracranial vessel evaluation beyond morphology, neuroradiology - diagnostics, aneurysm treatment, publishing a paper and ideas, pain and sleep disturbances, neuroradiological treatment of CF syndrome, diffusion tractography: research advancements and clinical applications.

  10. Atherosclerosis and Nanotechnology: Diagnostic and Therapeutic Applications.

    Kratz, Jeremy D; Chaddha, Ashish; Bhattacharjee, Somnath; Goonewardena, Sascha N


    Over the past several decades, tremendous advances have been made in the understanding, diagnosis, and treatment of coronary artery disease (CAD). However, with shifting demographics and evolving risk factors we now face new challenges that must be met in order to further advance are management of patients with CAD. In parallel with advances in our mechanistic appreciation of CAD and atherosclerosis, nanotechnology approaches have greatly expanded, offering the potential for significant improvements in our diagnostic and therapeutic management of CAD. To realize this potential we must go beyond to recognize new frontiers including knowledge gaps between understanding atherosclerosis to the translation of targeted molecular tools. This review highlights nanotechnology applications for imaging and therapeutic advancements in CAD.

  11. Use of the Isabel Decision Support System to Improve Diagnostic Accuracy of Pediatric Nurse Practitioner and Family Nurse Practitioner Students

    John, Rita Marie; Hall, Elizabeth; Bakken, Suzanne


    Patient safety is a priority for healthcare today. Despite a large proportion of malpractice claims the result of diagnostic error, the use of diagnostic decision support to improve diagnostic accuracy has not been widely used among healthcare professionals. Moreover, while the use of diagnostic decision support has been studied in attending physicians, residents, medical students and advanced practice nurses, the use of decision support among Advanced Practice Nurse (APN) students has not be...

  12. Multiplex PCR: Optimization and Application in Diagnostic Virology

    Elnifro, Elfath M.; Ashshi, Ahmed M.; Cooper, Robert J.; Klapper, Paul E.


    PCR has revolutionized the field of infectious disease diagnosis. To overcome the inherent disadvantage of cost and to improve the diagnostic capacity of the test, multiplex PCR, a variant of the test in which more than one target sequence is amplified using more than one pair of primers, has been developed. Multiplex PCRs to detect viral, bacterial, and/or other infectious agents in one reaction tube have been described. Early studies highlighted the obstacles that can jeopardize the production of sensitive and specific multiplex assays, but more recent studies have provided systematic protocols and technical improvements for simple test design. The most useful of these are the empirical choice of oligonucleotide primers and the use of hot start-based PCR methodology. These advances along with others to enhance sensitivity and specificity and to facilitate automation have resulted in the appearance of numerous publications regarding the application of multiplex PCR in the diagnosis of infectious agents, especially those which target viral nucleic acids. This article reviews the principles, optimization, and application of multiplex PCR for the detection of viruses of clinical and epidemiological importance. PMID:11023957

  13. Diagnostic laboratory technologies for the fetus and neonate with isoimmunization.

    Geaghan, Sharon Markham


    Maternal-fetal blood group incompatibility is common but less commonly results in hemolytic disease of the fetus and newborn (HDFN). HDFN is associated with greater peak bilirubin, at an earlier age, and for longer duration than other causes of hyperbilirubinemia. It poses a substantial risk for kernicterus and accounts for the majority of exchange transfusions for hyperbilirubinemia. Advances in diagnosis and management are described, from identification of the alloimmunized pregnancy by maternal ABO and Rh typing, antibody screen (indirect Coombs test), identification and titration; laboratory evaluation of the maternal-fetal unit with a critical maternal antibody titer to prompt fetal antigen status determination; assessment of fetomaternal hemorrhage by conventional Kleihauer-Betke testing or by flow cytometric methodology; to antenatal management of isoimmunization and fetal status assessments using the systems of Liley, Queenan, and serial Doppler fetal middle cerebral artery peak velocity measurements. The utility of laboratory diagnostics in the approach to hemolysis in the neonate, including hematology, chemistry, and peripheral blood smear review, is reviewed. The goal of management, to deliver a healthy infant at or near term, is attained for the majority of cases using current modalities; future directions include noninvasive genotyping of fetal blood from maternal serum to fully eliminate RhD alloimmunization and HDFN; and development of prophylaxis and intervention strategies for non-RhD alloimmunizations for which immune globulin is currently unavailable.

  14. Diagnostics in critical conditions



    Full Text Available The purpose of research: improvement of quality of diagnostics at the patients in a critical condition in intensive care unit. Material and methods. In total have analyzed 1957 medical cards of the patients who have died in ICU»s. At the first stage studied the factors influencing on diagnostics of critically ill patients (medical cards of 1557 patients; at the second stage investigated influence of the diagnostic standards in ICU»s practice on improvement of quality of diag- nostics of critically ill patients (400 medical cards of the patients who have died. Entry criterions were standards and algorithm of diagnostics. Techniques of research: average bed-day in groups, first-day lethality, quantity of the carried out laboratory tests and tool methods of research, level of consciousness of the patients (Glasgow come score, severity of disease by ICU»s patients (APACHE II scores. Results. Quality of diagnostics depend on carried out laboratory tests and tool methods of research, level of consciousness of the patients (Glasgow come score, severity of disease by ICU»s patients (APACHE II score. The conclusion. The laboratory tests and tool methods of research conforming to the standards of diagnostics are necessary for improvement of quality of diagnostics, it is necessary to take into account an altered level of consciousness (Glasgow come score and severity of disease by ICU»s patients (APACHE II scores

  15. Systematic Benchmarking of Diagnostic Technologies for an Electrical Power System

    Kurtoglu, Tolga; Jensen, David; Poll, Scott


    Automated health management is a critical functionality for complex aerospace systems. A wide variety of diagnostic algorithms have been developed to address this technical challenge. Unfortunately, the lack of support to perform large-scale V&V (verification and validation) of diagnostic technologies continues to create barriers to effective development and deployment of such algorithms for aerospace vehicles. In this paper, we describe a formal framework developed for benchmarking of diagnostic technologies. The diagnosed system is the Advanced Diagnostics and Prognostics Testbed (ADAPT), a real-world electrical power system (EPS), developed and maintained at the NASA Ames Research Center. The benchmarking approach provides a systematic, empirical basis to the testing of diagnostic software and is used to provide performance assessment for different diagnostic algorithms.

  16. Cable Diagnostic Focused Initiative

    Hartlein, R.A.; Hampton, R.N.


    This report summarizes an extensive effort made to understand how to effectively use the various diagnostic technologies to establish the condition of medium voltage underground cable circuits. These circuits make up an extensive portion of the electric delivery infrastructure in the United States. Much of this infrastructure is old and experiencing unacceptable failure rates. By deploying efficient diagnostic testing programs, electric utilities can replace or repair circuits that are about to fail, providing an optimal approach to improving electric system reliability. This is an intrinsically complex topic. Underground cable systems are not homogeneous. Cable circuits often contain multiple branches with different cable designs and a range of insulation materials. In addition, each insulation material ages differently as a function of time, temperature and operating environment. To complicate matters further, there are a wide variety of diagnostic technologies available for assessing the condition of cable circuits with a diversity of claims about the effectiveness of each approach. As a result, the benefits of deploying cable diagnostic testing programs have been difficult to establish, leading many utilities to avoid the their use altogether. This project was designed to help address these issues. The information provided is the result of a collaborative effort between Georgia Tech NEETRAC staff, Georgia Tech academic faculty, electric utility industry participants, as well as cable system diagnostic testing service providers and test equipment providers. Report topics include: •How cable systems age and fail, •The various technologies available for detecting potential failure sites, •The advantages and disadvantages of different diagnostic technologies, •Different approaches for utilities to employ cable system diagnostics. The primary deliverables of this project are this report, a Cable Diagnostic Handbook (a subset of this report) and an online

  17. Consideraciones para la aplicación del procesamiento ciclo estacionario avanzado al diagnóstico de cojinetes de rodamientos. // About the advanced cyclo-stationary processing application on rolling bearing diagnostic.

    F. E. Hernández Montero


    Full Text Available La aplicación del procesamiento ciclo-estacionario tradicional al análisis de vibraciones para el diagnóstico del estado delos cojinetes de rodamientos presenta un serio problema que se relaciona con la ocurrencia de falsas alarmas. En dosrecientes trabajos, sus autores han empleado técnicas diferentes para aplicar el procesamiento ciclo-estacionario “puro”, enaras de resolver este problema. En este trabajo se resumen las bases de estos trabajos y se comparan las técnicas másatractivas presentadas en tales investigaciones. Para efectuar la comparación, se simulan las señales de vibraciónproducidas por fallos locales en cojinetes de rodamientos, a partir de un modelo que constituye el más completo y prácticode los establecidos hasta el momento. Se mostró que el enfoque de aplicación del procesamiento ciclo-estacionario basadoen la mediana fue el que mejor resultado ofreció.Palabras claves: Análisis de vibraciones, diagnóstico de maquinarias, procesamiento cicloestacionario.__________________________________________________________________________Abstract:Traditional cyclostationary processing application on vibration analysis for rolling bearings condition diagnosis carries on a seriousproblem related to false alarms occurrence. Two recent researches describe the use of different techniques, based upon “pure”cyclostationary processing, in order to solve this problem. In this paper, basis of these works are summarized and the most suitedtechniques are compared. During comparison, vibrations produced by located rolling bearings failures are simulated using a practicaland completed model. The cyclostationary processing application based on the median probed to be more effective.Key Words: vibration analysis, machine condition diagnostic, cyclostationary processing.

  18. Diagnostic bronchoscopy: state of the art

    V. Ninane


    Full Text Available Since the introduction of the flexible fibreoptic bronchoscope in the late 1960s there have been relatively few technological advances for three decades, aside from the development of a white light video bronchoscope with a miniature charge-coupled device built in its tip replacing the fibreoptics. White light flexible videobronchoscopy with its ancillary devices (forceps biopsy, bronchial brushing, bronchoalveolar lavage, bronchial washings and transbronchial needle aspiration has long been the only established diagnostic bronchoscopic technique. With the advances in microtechnology over the past two decades, recent technical developments such as autofluorescence bronchoscopy and endoscopic ultrasound allow better evaluation of endobronchial, mediastinal and parenchymal lesions.

  19. Melioidosis Diagnostic Workshop, 20131

    AuCoin, David; Baccam, Prasith; Baggett, Henry C.; Baird, Rob; Bhengsri, Saithip; Blaney, David D.; Brett, Paul J.; Brooks, Timothy J.G.; Brown, Katherine A.; Chantratita, Narisara; Cheng, Allen C.; Dance, David A.B.; Decuypere, Saskia; Defenbaugh, Dawn; Gee, Jay E.; Houghton, Raymond; Jorakate, Possawat; Lertmemongkolchai, Ganjana; Limmathurotsakul, Direk; Merlin, Toby L.; Mukhopadhyay, Chiranjay; Norton, Robert; Peacock, Sharon J.; Rolim, Dionne B.; Simpson, Andrew J.; Steinmetz, Ivo; Stoddard, Robyn A.; Stokes, Martha M.; Sue, David; Tuanyok, Apichai; Whistler, Toni; Wuthiekanun, Vanaporn; Walke, Henry T.


    Melioidosis is a severe disease that can be difficult to diagnose because of its diverse clinical manifestations and a lack of adequate diagnostic capabilities for suspected cases. There is broad interest in improving detection and diagnosis of this disease not only in melioidosis-endemic regions but also outside these regions because melioidosis may be underreported and poses a potential bioterrorism challenge for public health authorities. Therefore, a workshop of academic, government, and private sector personnel from around the world was convened to discuss the current state of melioidosis diagnostics, diagnostic needs, and future directions. PMID:25626057

  20. Diagnostic Accuracy of CBCT for Aggressive Periodontitis

    Ranjana Mohan; Ruhi Mark; Ipsa Sing; Ankita Jain


    Cone beam computed tomography (CBCT) is an indispensable diagnostic imaging tool for dento-alveolar examination. CBCT scanning has become a valuable imaging modality in the field of Periodontology for the detection of very small osseous defects. A patient reported to the department of Periodontology with a complaint of loose teeth. Clinical and direct digital radiographic (DDR) examination revealed advanced periodontal destruction, but failed to diagnose the morphology of generalized osseous ...

  1. Training for advanced endoscopic procedures.

    Feurer, Matthew E; Draganov, Peter V


    Advanced endoscopy has evolved from diagnostic ERCP to an ever-increasing array of therapeutic procedures including EUS with FNA, ablative therapies, deep enteroscopy, luminal stenting, endoscopic suturing and endoscopic mucosal resection among others. As these procedures have become increasingly more complex, the risk of potential complications has also risen. Training in advanced endoscopy involves more than obtaining a minimum number of therapeutic procedures. The means of assessing a trainee's competence level and ability to practice independently continues to be a matter of debate. The use of quality indicators to measure performance levels may be beneficial as more advanced techniques and procedures become available.

  2. Methodology, Meditation, and Mindfulness

    Balveer Singh Sikh


    Full Text Available Understanding the nondualistic nature of mindfulness is a complex and challenging task particularly when most clinical psychology draws from Western methodologies and methods. In this article, we argue that the integration of philosophical hermeneutics with Eastern philosophy and practices may provide a methodology and methods to research mindfulness practice. Mindfulness hermeneutics brings together the nondualistically aligned Western philosophies of Heidegger and Gadamer and selected Eastern philosophies and practices in an effort to bridge the gap between these differing worldviews. Based on the following: (1 fusion of horizons, (2 being in a hermeneutic circle, (3 understanding as intrinsic to awareness, and (4 the ongoing practice of meditation, a mindfulness hermeneutic approach was used to illuminate deeper understandings of mindfulness practice in ways that are congruent with its underpinning philosophies.


    Lanskaya D. V.


    Full Text Available Outsourcing is investigated from a position of finding steady and unique competitive advantages of a public corporation due to attraction of carriers of unique intellectual and uses social capitals of the specialized companies within the institutional theory. Key researchers and events in the history of outsourcing are marked out, the existing approaches to definition of the concept of outsourcing, advantage and risks from application of technology of outsourcing are considered. It is established that differences of outsourcing, sub-contraction and cooperation are not in the nature of the functional relations, and in the depth of considered economic terms and phenomena. The methodology of outsourcing is considered as a part of methodology of cooperation of enterprise innovative structures of being formed sector of knowledge economy

  4. Transparent Guideline Methodology Needed

    Lidal, Ingeborg; Norén, Camilla; Mäkelä, Marjukka


    As part of learning at the Nordic Workshop of Evidence-based Medicine, we have read with interest the practice guidelines for central venous access, published in your Journal in 2012.1 We appraised the quality of this guideline using the checklist developed by The Evidence-Based Medicine Working ...... are based on best currently available evidence. Our concerns are in two main categories: the rigor of development, including methodology of searching, evaluating, and combining the evidence; and editorial independence, including funding and possible conflicts of interest....... Group.2 Similar criteria for guideline quality have been suggested elsewhere.3 Our conclusion was that this much needed guideline is currently unclear about several aspects of the methodology used in developing the recommendations. This means potential users cannot be certain that the recommendations...

  5. Soft Systems Methodology

    Checkland, Peter; Poulter, John

    Soft systems methodology (SSM) is an approach for tackling problematical, messy situations of all kinds. It is an action-oriented process of inquiry into problematic situations in which users learn their way from finding out about the situation, to taking action to improve it. The learning emerges via an organised process in which the situation is explored using a set of models of purposeful action (each built to encapsulate a single worldview) as intellectual devices, or tools, to inform and structure discussion about a situation and how it might be improved. This paper, written by the original developer Peter Checkland and practitioner John Poulter, gives a clear and concise account of the approach that covers SSM's specific techniques, the learning cycle process of the methodology and the craft skills which practitioners develop. This concise but theoretically robust account nevertheless includes the fundamental concepts, techniques, core tenets described through a wide range of settings.

  6. Tobacco documents research methodology.

    Anderson, Stacey J; McCandless, Phyra M; Klausner, Kim; Taketa, Rachel; Yerger, Valerie B


    Tobacco documents research has developed into a thriving academic enterprise since its inception in 1995. The technology supporting tobacco documents archiving, searching and retrieval has improved greatly since that time, and consequently tobacco documents researchers have considerably more access to resources than was the case when researchers had to travel to physical archives and/or electronically search poorly and incompletely indexed documents. The authors of the papers presented in this supplement all followed the same basic research methodology. Rather than leave the reader of the supplement to read the same discussion of methods in each individual paper, presented here is an overview of the methods all authors followed. In the individual articles that follow in this supplement, the authors present the additional methodological information specific to their topics. This brief discussion also highlights technological capabilities in the Legacy Tobacco Documents Library and updates methods for organising internal tobacco documents data and findings.

  7. Land evaluation methodology

    Lustig, Thomas


    This paper reviews non-computerised and computerised land evaluation methods or methodologies, and realises the difficulties to incorporate biophysical and socioeconomic factors from different levels. Therefore, this paper theorises an alternative land evaluation approach, which is tested and elaborated in an agricultural community in the North of Chile. The basis of the approach relies on holistic thinking and attempts to evaluate the potential for improving assumed unsustainable goat manage...

  8. Pipeline ADC Design Methodology

    Zhao, Hui


    Demand for high-performance analog-to-digital converter (ADC) integrated circuits (ICs) with optimal combined specifications of resolution, sampling rate and power consumption becomes dominant due to emerging applications in wireless communications, broad band transceivers, digital-intermediate frequency (IF) receivers and countless of digital devices. This research is dedicated to develop a pipeline ADC design methodology with minimum power dissipation, while keeping relatively high speed an...

  9. Albert Einstein's Methodology

    Weinstein, Galina


    This paper discusses Einstein's methodology. 1. Einstein characterized his work as a theory of principle and reasoned that beyond kinematics, the 1905 heuristic relativity principle could offer new connections between non-kinematical concepts. 2. Einstein's creativity and inventiveness and process of thinking; invention or discovery. 3. Einstein considered his best friend Michele Besso as a sounding board and his class-mate from the Polytechnic Marcel Grossman, as his active partner. Yet, Ein...

  10. Pipeline ADC Design Methodology

    Zhao, Hui


    Demand for high-performance analog-to-digital converter (ADC) integrated circuits (ICs) with optimal combined specifications of resolution, sampling rate and power consumption becomes dominant due to emerging applications in wireless communications, broad band transceivers, digital-intermediate frequency (IF) receivers and countless of digital devices. This research is dedicated to develop a pipeline ADC design methodology with minimum power dissipation, while keeping relatively high speed an...

  11. Thioaptamer Diagnostic System Project

    National Aeronautics and Space Administration — AM Biotechnologies (AM) in partnership with Sandia National Laboratories will develop a Thioaptamer Diagnostic System (TDS) in response to Topic X10.01 Reusable...

  12. Rotorcraft Diagnostics Project

    National Aeronautics and Space Administration — Under this SBIR program, Ridgetop will introduce the first low-cost, low-power, and lightweight data monitoring solution for rotorcraft diagnostics. The solution is...

  13. National Convective Weather Diagnostic

    National Oceanic and Atmospheric Administration, Department of Commerce — Current convective hazards identified by the National Convective Weather Detection algorithm. The National Convective Weather Diagnostic (NCWD) is an automatically...

  14. Prenatal Genetic Diagnostic Tests

    ... are offered to all pregnant women. What is amniocentesis? Amniocentesis is a diagnostic test. It usually is done ... a very small chance of pregnancy loss with amniocentesis. Leakage of amniotic fluid and slight bleeding can ...

  15. Diagnosing Conceptions about the Epistemology of Science: Contributions of a Quantitative Assessment Methodology

    Vázquez-Alonso, Ángel; Manassero-Mas, María-Antonia; García-Carmona, Antonio; Montesano de Talavera, Marisa


    This study applies a new quantitative methodological approach to diagnose epistemology conceptions in a large sample. The analyses use seven multiple-rating items on the epistemology of science drawn from the item pool Views on Science-Technology-Society (VOSTS). The bases of the new methodological diagnostic approach are the empirical…

  16. Psychobiological operationalization of RDoC constructs: Methodological and conceptual opportunities and challenges.

    MacNamara, Annmarie; Phan, K Luan


    NIMH's Research Domain Criteria (RDoC) project seeks to advance the diagnosis, prevention, and treatment of mental disorders by promoting psychobiological research on dimensional constructs that might cut across traditional diagnostic boundaries (Kozak & Cuthbert, ). At the core of this approach is the notion that these dimensional constructs can be assessed across different units of analysis (e.g., genes, physiology, behavior), enriching the constructs and providing more complete explanations of clinical problems. While the conceptual aspects of RDoC have been discussed in several prior papers, its methodological aspects have received comparatively less attention. For example, how to integrate data from different units of analysis has been relatively unclear. Here, we discuss one means of psychobiologically operationalizing RDoC constructs across different units of analysis (the psychoneurometric approach; Yancey et al., ), highlighting ways in which this approach might be refined in future iterations. We conclude that there is much to be learned from this technique; however, greater attention to scale-development methods and to psychometrics will likely benefit this and other methodological approaches to combining measurements across multiple units of analysis.

  17. [Diagnostics in osteology].

    Jakob, F; Genest, F; Seefried, L; Tsourdi, E; Lapa, C; Hofbauer, L C


    Clinical diagnostics in metabolic bone diseases cover a broad spectrum of conventional and state of the art methods ranging from the medical history and clinical examination to molecular imaging. Patient treatment is carried out in an interdisciplinary team due to the multiple interactions of bone with other organ systems. Diagnosis of osteoporosis is supported by high level national guidelines. A paradigm shift concerning the clinical relevance of bone mineral density measurement renders this now to be a strong risk factor rather than a diagnostic parameter, while strengthening the value of other clinical factors for risk assessment. The impact of parameters for muscle mass, structure and function is steadily increasing in all age groups. In order to identify underlying diseases that influence bone metabolism a panel of general laboratory diagnostic parameters is recommended. Markers for bone formation and resorption and specific parameters for the regulation of calcium and phosphate metabolism should be evaluated by specialists because they require diligence in preanalytics and experience in interpretation. Genetic diagnosis is well established for rare bone diseases while diagnostic panels are not yet available for routine diagnostics in polygenetic diseases such as osteoporosis. Conventional radiology is still very important to identify, e. g. fractures, osteolytic and osteoblastic lesions and extraosseous calcifications; however tomography-based methods which combine, e. g. scintigraphy or positron emission technologies with anatomical imaging are of increasing significance. Clinical diagnostics in osteology require profound knowledge and are subject to a dynamic evolution.

  18. Optics/Optical Diagnostics Laboratory

    Federal Laboratory Consortium — The Optics/Optical Diagnostics Laboratory supports graduate instruction in optics, optical and laser diagnostics and electro-optics. The optics laboratory provides...

  19. Optimizing Feedlot Diagnostic Testing Strategies Using Test Characteristics, Disease Prevalence, and Relative Costs of Misdiagnosis.

    Theurer, Miles E; White, Brad J; Renter, David G


    Diagnostic tests are commonly used by feedlot practitioners and range from clinical observations to more advanced physiologic testing. Diagnostic sensitivity and specificity, estimated prevalence in the population, and the costs of misdiagnoses need to be considered when selecting a diagnostic test strategy and interpreting results. This article describes methods for evaluating diagnostic strategies using economic outcomes to evaluate the most appropriate strategy for the expected situation. The diagnostic sensitivity and specificity, and expected prevalence influence the likelihood of misdiagnosis in a given population, and the estimated direct economic impact can be used to quantify differences among diagnostic strategies.

  20. Developing computational model-based diagnostics to analyse clinical chemistry data

    Schalkwijk, D.B. van; Bochove, K. van; Ommen, B. van; Freidig, A.P.; Someren, E.P. van; Greef, J. van der; Graaf, A.A. de


    This article provides methodological and technical considerations to researchers starting to develop computational model-based diagnostics using clinical chemistry data.These models are of increasing importance, since novel metabolomics and proteomics measuring technologies are able to produce large

  1. Microgenetic Analysis of Moral Development: Theoretical and Methodological Issues

    Barrios, Alia; Barbato,Silviane; Branco,Angela


    New ideas and methodologies need to be developed to advance our knowledge in the understanding of moral development. The intertwined nature of human activities, communication processes, and the numerous aspects of morality pose a challenge to researchers to construct a methodology that takes into account cognition, affect, sociocultural processes and characteristics, as well as the active role of individuals in their own development. In this paper we aim at suggesting fresh theoretical ideas ...

  2. Handbook of Advanced Multilevel Analysis

    Hox, Joop


    This new handbook is the definitive resource on advanced topics related to multilevel analysis. The editors have assembled the top minds in the field to address the latest applications of multilevel modeling as well as the specific difficulties and methodological problems that are becoming more common as more complicated models are developed.

  3. Investigating surety methodologies for cognitive systems.

    Caudell, Thomas P. (University of New Mexico, Albuquerque, NM); Peercy, David Eugene; Mills, Kristy (University of New Mexico, Albuquerque, NM); Caldera, Eva (University of New Mexico, Albuquerque, NM)


    Advances in cognitive science provide a foundation for new tools that promise to advance human capabilities with significant positive impacts. As with any new technology breakthrough, associated technical and non-technical risks are involved. Sandia has mitigated both technical and non-technical risks by applying advanced surety methodologies in such areas as nuclear weapons, nuclear reactor safety, nuclear materials transport, and energy systems. In order to apply surety to the development of cognitive systems, we must understand the concepts and principles that characterize the certainty of a system's operation as well as the risk areas of cognitive sciences. This SAND report documents a preliminary spectrum of risks involved with cognitive sciences, and identifies some surety methodologies that can be applied to potentially mitigate such risks. Some potential areas for further study are recommended. In particular, a recommendation is made to develop a cognitive systems epistemology framework for more detailed study of these risk areas and applications of surety methods and techniques.

  4. Advances in Artificial Neural Networks - Methodological Development and Application

    Artificial neural networks as a major soft-computing technology have been extensively studied and applied during the last three decades. Research on backpropagation training algorithms for multilayer perceptron networks has spurred development of other neural network training algorithms for other ne...

  5. Advanced Bridge Capacity and Structural Integrity Assessment Methodology


    Wickline, Cousins and Seda -Sanabria 2003, ACI Committee 435 1966). In this project, the extent of cracking along the beam was considered by looking at...Shear." ACI Journal, March-April 1986: 219-231. ERDC/CERL TR-13-3 104 Wickline, Joseph E., Thomas E. Cousins, and Yazmin Seda -Sanabria. "ERDC/GSL TR

  6. A Systems Engineering Methodology for the Advanced Tactical Aircraft.


    and a nunber of contingencies to be planned for. The problens included radiation hazard due to solar storns and the Uan Allen Belts and the potential...School by LCOR S. Carro , on 2 Hou 1984. 35. "Uariety of Hew Trainers Conpete for Military 1larket," Auiation Meek 9 Space Technology, 19 Houenber

  7. Recent methodological advances in the analysis of protein tyrosine nitration.

    Díaz-Moreno, Irene; García-Heredia, José M; González-Arzola, Katiuska; Díaz-Quintana, Antonio; De la Rosa, Miguel Á


    Tyrosine nitration is a common post-translational modification affecting protein structure and function. It is based on the addition of a -NO2 group at the ortho position of the phenolic hydroxyl group of tyrosine to yield 3-nitrotyrosine (3-NTyr). Understanding how tyrosine nitration affects the structure and functionality of proteins is of considerable interest, as it is associated with pathogenesis in diseases related to oxidative stress in all living organisms. There are several methods to nitrate tyrosine residues in native proteins. Among them, nitration by the chemical agent peroxynitrite stands out for its biological relevance. Recently, a genetically evolved suppressor tRNA has been developed to provide in vivo incorporation of 3-NTyr into proteins. In this minireview, we discuss the advantages and limitations of these chemical and biological methods and propose a non-damaging method to analyze the configuration and dynamics of nitrotyrosine residues in native proteins by NMR spectroscopy. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Methodological advances: using greenhouses to simulate climate change scenarios.

    Morales, F; Pascual, I; Sánchez-Díaz, M; Aguirreolea, J; Irigoyen, J J; Goicoechea, N; Antolín, M C; Oyarzun, M; Urdiain, A


    Human activities are increasing atmospheric CO2 concentration and temperature. Related to this global warming, periods of low water availability are also expected to increase. Thus, CO2 concentration, temperature and water availability are three of the main factors related to climate change that potentially may influence crops and ecosystems. In this report, we describe the use of growth chamber - greenhouses (GCG) and temperature gradient greenhouses (TGG) to simulate climate change scenarios and to investigate possible plant responses. In the GCG, CO2 concentration, temperature and water availability are set to act simultaneously, enabling comparison of a current situation with a future one. Other characteristics of the GCG are a relative large space of work, fine control of the relative humidity, plant fertirrigation and the possibility of light supplementation, within the photosynthetic active radiation (PAR) region and/or with ultraviolet-B (UV-B) light. In the TGG, the three above-mentioned factors can act independently or in interaction, enabling more mechanistic studies aimed to elucidate the limiting factor(s) responsible for a given plant response. Examples of experiments, including some aimed to study photosynthetic acclimation, a phenomenon that leads to decreased photosynthetic capacity under long-term exposures to elevated CO2, using GCG and TGG are reported.

  9. Metacontingencies, Experimentation and Nonhumans: Searching for Conceptual and Methodological Advances

    Saulo Missiaggia Velasco


    Full Text Available La metacontingencia ha sido descrita como la relación funcional entre las contingencias conductuales entrelazadas, junto con su efecto directo e inmediato, llamado producto agregado, y un evento seleccionador dependiente de dicho efecto, llamado consecuencia cultural. El análisis metacontingencial permite la discusión de la complejidad del comportamiento humano en los sistemas sociales. En el presente estudio, quisimos revisar y discutir: (a la importancia del análisis de procesos conductuales básicos para la comprensión de los fenómenos sociales humanos; (b la necesidad de construir y mejorar los modelos experimentales de metacontingencias; (c el estado actual de las investigaciones experimentales en metacontingencias; (d el uso de modelos animales como forma de controlar los efectos de la conducta verbal, entre otras variables, sobre la selección cultural; (e una propuesta concreta e ilustrativa de un modelo animal de metacontingencias.


    Ben Grunewald; Paul Jehn


    By early 2000, fifteen oil and gas State Agencies were using RBDMS or a RBDMS utility to handle a significant amount or all of their data management needs. There are three additional State slated to begin implementation this year. There are an additional twelve State agencies that are not utilizing this technology that have proven to be very useful for so many other States. This project will allow for the base RBDMS install in all State oil and gas agency that desire it.

  11. Advanced High Cycle Fatigue (HCF) Life Assurance Methodologies


    Kk Rcaa σπ σπ (K5) Note that ao and co depend on the assumed aspect ratio of a vanishing small initiated crack through the dependence of the...constant/,0,0()( 1,/ ⎥ ⎦ ⎤ ⎢ ⎣ ⎡ =→→∆ ∆ = ⎥ ⎦ ⎤ ⎢ ⎣ ⎡ =→→∆ ∆ = iRcie th io iRaie th io RfcacafR K Rcac RfcacafR K Rcaa σπ σπ (K6) It is clear from

  12. Advances in strategies and methodologies in cancer immunotherapy.

    Lam, Samuel S K; Zhou, Feifan; Hode, Tomas; Nordquist, Robert E; Alleruzzo, Luciano; Raker, Joseph; Chen, Wei R


    Since the invention of Coley's toxin by William Coley in early 1900s, the path for cancer immunotherapy has been a convoluted one. Although still not considered standard of care, with the FDA approval of trastuzumab, Provenge and ipilimumab, the medical and scientific community has started to embrace the possibility that immunotherapy could be a new hope for cancer patients with otherwise untreatable metastatic diseases. This review aims to summarize the development of some major strategies in cancer immunotherapy, from the earliest peptide vaccine and transfer of tumor specific antibodies/T cells to the more recent dendritic cell (DC) vaccines, whole cell tumor vaccines, and checkpoint blockade therapy. Discussion of some major milestones and obstacles in the shaping of the field and the future perspectives is included. Photoimmunotherapy is also reviewed as an example of emerging new therapies combining phototherapy and immunotherapy.

  13. Advancing Recommender Systems from the Algorithm, Interface and Methodological Perspective



    I sistemi di raccomandazione sono componenti software che aiutano gli utenti a trovare quello che stanno cercando. I sistemi di raccomandazione sono stati applicati a diverse aree, dal commercio elettronico alle notizie, dalla musica al turismo, sfruttando tutte le informazioni disponibili per imparare le preferenze dell’utente e fornire raccomandazioni utili. La vasta area dei sistemi di raccomandazione riguarda molte tematiche che richiedono una conoscenza profonda e grandi sforzi di ric...

  14. Methodological Advances for Detecting Physiological Synchrony During Dyadic Interactions

    McAssey, M.P.; Helm, J.; Hsieh, F.; Sbarra, D.; Ferrer, E.


    A defining feature of many physiological systems is their synchrony and reciprocal influence. An important challenge, however, is how to measure such features. This paper presents two new approaches for identifying synchrony between the physiological signals of individuals in dyads. The approaches a

  15. Interval Methods for Model Qualification: Methodology and Advanced Application

    Alexandre dit Sandretto, Julien; Trombettoni, Gilles; Daney, David


    It is often too complex to use, and sometimes impossible to obtain, an actual model in simulation or command field . To handle a system in practice, a simplification of the real model is then necessary. This simplification goes through some hypotheses made on the system or the modeling approach. In this paper, we deal with all models that can be expressed by real-valued variables involved in analytical relations and depending on parameters. We propose a method that qualifies the simplificatio...

  16. Emerging issues and methodological advances in fisheries reproductive biology

    Lowerre-Barbieri, Susan K.; Brown-Peterson, Nancy J.; Murua, Hilario;


    Although incorporating detailed reproductive data into all stock assessments is not a practical goal, the need to understand how reproductive biology affects population productivity is being increasingly recognized.More research focused on reproductive biology—coupled with a shift towards...... development, which is most accurately evaluated with histology. This special section of Marine and Coastal Fisheries contains contributions from a workshop on the gonadal histology of fishes that was held in Cadiz, Spain, during June 2009. These papers cover a wide range of species and reproductive topics...... a resilience perspective in fisheries science—is resulting in challenges to many long-held assumptions; the emergence of important new issues; and identification of the need to improve data and methods used in reproductive studies. Typically, data for reproductive studies are based on an assessment of gonadal...

  17. Differing antidepressant maintenance methodologies.

    Safer, Daniel J


    The principle evidence that antidepressant medication (ADM) is an effective maintenance treatment for adults with major depressive disorder (MDD) is from placebo substitution trials. These trials enter responders from ADM efficacy trials into randomized, double-blind placebo-controlled (RDBPC) effectiveness trials to measure the rate of MDD relapse over time. However, other randomized maintenance trial methodologies merit consideration and comparison. A systematic review of ADM randomized maintenance trials included research reports from multiple databases. Relapse rate was the main effectiveness outcome assessed. Five ADM randomized maintenance methodologies for MDD responders are described and compared for outcome. These effectiveness trials include: placebo-substitution, ADM/placebo extension, ADM extension, ADM vs. psychotherapy, and treatment as usual. The placebo-substitution trials for those abruptly switched to placebo resulted in unusually high (46%) rates of relapse over 6-12months, twice the continuing ADM rate. These trials were characterized by selective screening, high attrition, an anxious anticipation of a switch to placebo, and a risk of drug withdrawal symptoms. Selectively screened ADM efficacy responders who entered into 4-12month extension trials experienced relapse rates averaging ~10% with a low attrition rate. Non-industry sponsored randomized trials of adults with multiple prior MDD episodes who were treated with ADM maintenance for 1-2years experienced relapse rates averaging 40%. Placebo substitution trial methodology represents only one approach to assess ADM maintenance. Antidepressant maintenance research for adults with MDD should be evaluated for industry sponsorship, attrition, the impact of the switch to placebo, and major relapse differences in MDD subpopulations. Copyright © 2017. Published by Elsevier Inc.

  18. Organizing the Diagnostics of Multicultural Personality in College Students

    Begaliyeva, Saule; Issabekova, Gulnur; Saudabaeva, Gulmira; Zhanna, Axakalova; Abdildaev, Abdikhalyk Kosherbayuly


    The aim of present study is to reveal the actual state of multicultural personality development in college students, based on a specially selected diagnostic inventory. The problem of multicultural personality development on the level of present pedagogics development allows taking the leading methodologic theories and approaches as the bases.…


    S. YU. Buryak


    Full Text Available Purpose. In the paper it is necessary to: 1 find out the causes of turnouts faults to determine diagnostic features failures; 2 consider the requirements structure, purpose components of turnouts, work and technology of their maintenance to determine the construction of the economic activities related to system to the turnout’s maintenance; 3 substantiate the possibility, necessity and prospects of automated diagnostics turnout’s implementation; 4 elaborate a prototype of an automated hardware and software system for the turnouts control parameters and perform diagnostics on them. Methodology. In the paper possible turnouts faults were presented and manifestations and influence on its work were shown. According to the current technology works the process analyze of turnouts’ maintenance was conducted, were defined the basic performed operations during the examination of appearance, parameters and check the repair or replacement of parts and assemblies. Based on the analysis of reasons of turnouts malfunctioning and their fixes were systematized types of damages and ways to deal with them, an information scheme of troubleshooting were created, opportunities and limits of automating the process of diagnostics were identified and compared with the existing method of turnouts maintenance. A diagnostics system block diagram was created, an algorithm of its work was developed and established main basic principles of operation. Software and hardware to determine the turnout’s state considering diagnostic performance of points in use were applied. Findings. During the experiment was created a method of automated turnout’s diagnostics with AC electric drives, managed centrally. The results of automated hardware and software system make it possible to control turnout’s parameters and perform diagnostics on them. Originality. Authors created the method of turnout’s state determination by current curve and its spectral composition in the

  20. Sample size methodology

    Desu, M M


    One of the most important problems in designing an experiment or a survey is sample size determination and this book presents the currently available methodology. It includes both random sampling from standard probability distributions and from finite populations. Also discussed is sample size determination for estimating parameters in a Bayesian setting by considering the posterior distribution of the parameter and specifying the necessary requirements. The determination of the sample size is considered for ranking and selection problems as well as for the design of clinical trials. Appropria

  1. Literacy research methodologies

    Duke, Nell K


    The definitive reference on literacy research methods, this book serves as a key resource for researchers and as a text in graduate-level courses. Distinguished scholars clearly describe established and emerging methodologies, discuss the types of questions and claims for which each is best suited, identify standards of quality, and present exemplary studies that illustrate the approaches at their best. The book demonstrates how each mode of inquiry can yield unique insights into literacy learning and teaching and how the methods can work together to move the field forward.   New to This Editi

  2. Internalism as Methodology

    Terje Lohndal


    Full Text Available This paper scrutinizes the recent proposal made by Lassiter (2008 that the dichotomy between Chomskyan internalism and Dummett-type externalism is misguided and should be overcome by an approach that incorporates sociolinguistic concepts such as speakers’ dispositions to defer. We argue that Lassiter’s arguments are flawed and based on a serious misunder-standing of the internalist approach to the study of natural language, failing to appreciate its methodological nature and conclude that Lassiter’s socio-linguistic approach is just another instance of externalist attempts with little hope of scientific achievement.

  3. The New Methodology


    In the past few years there's been a rapidly growing interest in“lightweight” methodologies. Alternatively characterized as an antidote to bureaucracy or a license to hack they've stirred up interest all over the software landscape. In this essay I explore the reasons for lightweight methods, focusing not so much on their weight but on their adaptive nature and their people-first orientation . I also give a summary and references to the processes in this school and consider the factors that should influence your choice of whether to go down this newly trodden path.

  4. Current development of saliva/oral fluid-based diagnostics.

    Yeh, Chih-Ko; Christodoulides, Nicolaos J; Floriano, Pierre N; Miller, Craig S; Ebersole, Jeffrey L; Weigum, Shannon E; McDevitt, John; Redding, Spencer W


    Saliva can be easily obtained in medical and non-medical settings, and contains numerous bio-molecules, including those typically found in serum for disease detection and monitoring. In the past two decades, the achievements of high-throughput approaches afforded by biotechnology and nanotechnology allow for disease-specific salivary biomarker discovery and establishment of rapid, multiplex, and miniaturized analytical assays. These developments have dramatically advanced saliva-based diagnostics. In this review, we discuss the current consensus on development of saliva/oral fluid-based diagnostics and provide a summary of recent research advancements of the Texas-Kentucky Saliva Diagnostics Consortium. In the foreseeable future, current research on saliva based diagnostic methods could revolutionize health care.

  5. Infrared imaging diagnostics for INTF ion beam

    Sudhir, D.; Bandyopadhyay, M.; Pandey, R.; Joshi, J.; Yadav, A.; Rotti, C.; Bhuyan, M.; Bansal, G.; Soni, J.; Tyagi, H.; Pandya, K.; Chakraborty, A.


    In India, testing facility named INTF [1] (Indian test facility) is being built in Institute for Plasma Research to characterize ITER-Diagnostic Neutral Beam (DNB). INTF is expected to deliver 60A negative hydrogen ion beam current of energy 100keV. The beam will be operated with 5Hz modulation having 3s ON/20s OFF duty cycle. To characterize the beam parameters several diagnostics are at different stages of design and development. One of them will be a beam dump, made of carbon fiber composite (CFC) plates placed perpendicular to the beam direction at a distance lm approximately. The beam dump needs to handle ˜ 6MW of beam power with peak power density ˜ 38.5MW/m2. The diagnostic is based on thermal (infra-red - IR) imaging of the footprint of the 1280 beamlets falling on the beam dump using four IR cameras from the rear side of the dump. The beam dump will be able to measure beam uniformity, beamlet divergence. It may give information on relative variation of negative ion stripping losses for different beam pulses. The design of this CFC based beam dump needs to address several physics and engineering issues, including some specific inputs from manufacturers. The manuscript will describe an overview of the diagnostic system and its design methodology highlighting those issues and the present status of its development.

  6. Radial pseudoaneurysm following diagnostic coronary angiography

    Shankar Laudari


    Full Text Available The radial artery access has gained popularity as a method of diagnostic coronary catheterization compared to femoral artery puncture in terms of vascular complications and early ambulation. However, very rare complication like radial artery pseudoaneurysm may occur following cardiac catheterization which may give rise to serious consequences. Here, we report a patient with radial pseudoaneurysm following diagnostic coronary angiography. Adequate and correct methodology of compression of radial artery following puncture for maintaining hemostasis is the key to prevention.DOI: Journal of College of Medical Sciences-Nepal, 2014, Vol-10, No-3, 48-50

  7. Development of Companion Diagnostics.

    Mankoff, David A; Edmonds, Christine E; Farwell, Michael D; Pryma, Daniel A


    The goal of individualized and targeted treatment and precision medicine requires the assessment of potential therapeutic targets to direct treatment selection. The biomarkers used to direct precision medicine, often termed companion diagnostics, for highly targeted drugs have thus far been almost entirely based on in vitro assay of biopsy material. Molecular imaging companion diagnostics offer a number of features complementary to those from in vitro assay, including the ability to measure the heterogeneity of each patient's cancer across the entire disease burden and to measure early changes in response to treatment. We discuss the use of molecular imaging methods as companion diagnostics for cancer therapy with the goal of predicting response to targeted therapy and measuring early (pharmacodynamic) response as an indication of whether the treatment has "hit" the target. We also discuss considerations for probe development for molecular imaging companion diagnostics, including both small-molecule probes and larger molecules such as labeled antibodies and related constructs. We then describe two examples where both predictive and pharmacodynamic molecular imaging markers have been tested in humans: endocrine therapy for breast cancer and human epidermal growth factor receptor type 2-targeted therapy. The review closes with a summary of the items needed to move molecular imaging companion diagnostics from early studies into multicenter trials and into the clinic.

  8. MJO Simulation Diagnostics

    Waliser, D; Sperber, K; Hendon, H; Kim, D; Maloney, E; Wheeler, M; Weickmann, K; Zhang, C; Donner, L; Gottschalck, J; Higgins, W; Kang, I; Legler, D; Moncrieff, M; Schubert, S; Stern, W; Vitart, F; Wang, B; Wang, W; Woolnough, S


    The Madden-Julian Oscillation (MJO) interacts with, and influences, a wide range of weather and climate phenomena (e.g., monsoons, ENSO, tropical storms, mid-latitude weather), and represents an important, and as yet unexploited, source of predictability at the subseasonal time scale. Despite the important role of the MJO in our climate and weather systems, current global circulation models (GCMs) exhibit considerable shortcomings in representing this phenomenon. These shortcomings have been documented in a number of multi-model comparison studies over the last decade. However, diagnosis of model performance has been challenging, and model progress has been difficult to track, due to the lack of a coherent and standardized set of MJO diagnostics. One of the chief objectives of the US CLIVAR MJO Working Group is the development of observation-based diagnostics for objectively evaluating global model simulations of the MJO in a consistent framework. Motivation for this activity is reviewed, and the intent and justification for a set of diagnostics is provided, along with specification for their calculation, and illustrations of their application. The diagnostics range from relatively simple analyses of variance and correlation, to more sophisticated space-time spectral and empirical orthogonal function analyses. These diagnostic techniques are used to detect MJO signals, to construct composite life-cycles, to identify associations of MJO activity with the mean state, and to describe interannual variability of the MJO.

  9. Induced pluripotent stem cells: advances to applications

    Timothy J Nelson


    Full Text Available Timothy J Nelson1, Almudena Martinez-Fernandez1, Satsuki Yamada1, Yasuhiro Ikeda2, Carmen Perez-Terzic1, Andre Terzic11Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA; 2Department of Molecular Medicine; Mayo Clinic, Rochester, Minnesota, USAAbstract: Induced pluripotent stem cell (iPS technology has enriched the armamentarium of regenerative medicine by introducing autologous pluripotent progenitor pools bioengineered from ordinary somatic tissue. Through nuclear reprogramming, patient-specific iPS cells have been derived and validated. Optimizing iPS-based methodology will ensure robust applications across discovery science, offering opportunities for the development of personalized diagnostics and targeted therapeutics. Here, we highlight the process of nuclear reprogramming of somatic tissues that, when forced to ectopically express stemness factors, are converted into bona fide pluripotent stem cells. Bioengineered stem cells acquire the genuine ability to generate replacement tissues for a wide-spectrum of diseased conditions, and have so far demonstrated therapeutic benefit upon transplantation in model systems of sickle cell anemia, Parkinson’s disease, hemophilia A, and ischemic heart disease. The field of regenerative medicine is therefore primed to adopt and incorporate iPS cell-based advancements as a next generation stem cell platforms.Keywords: iPS, regenerative medicine, individualized medicine, stem cell therapy

  10. [Biotechnological advances in infectious diseases diagnosis].

    Hernández-Hernández, Fidel de la Cruz; Rodríguez, Mario H


    The detection of molecules of pathogens (antigens and genetic material) and host molecules in response to infections (antibodies) is the basic principle involved in molecular diagnostic tests. These tests have avoided the need to detect the attacking pathogen. New advances in molecular biology and the development of robotic technology and genomic and protein sequencing have allowed for the development of new high performance and highly specific tests. Genomics and proteomics contribute to the identification of biomarkers and biotechnology provides methods to produce high purity reagents. The identification of coding genes of specific antigens, their cloning and recombinant production, the production of monoclonal antibodies, their fragments and single chain antibodies enabled new, safer, high sensitivity and specificity immunological techniques to develop. New recognition molecules, including aptamers, will soon replace the need to produce antibodies by immunization. For the detection of genetic material, new methodological strategies based on hybridization and amplification (PCR, end point and real time) in multiplex and microarray formats have been developed, and for their detection new reporter molecules have been designed that enable their quantification. Although these methods require sophisticated instrumentation, they will soon be accessible for application in public health.

  11. Scrum methodology in banking environment

    Strihová, Barbora


    Bachelor thesis "Scrum methodology in banking environment" is focused on one of agile methodologies called Scrum and description of the methodology used in banking environment. Its main goal is to introduce the Scrum methodology and outline a real project placed in a bank focused on software development through a case study, address problems of the project, propose solutions of the addressed problems and identify anomalies of Scrum in software development constrained by the banking environmen...

  12. Diagnostic test evaluation for Trichinella infections in pigs: a renewed interaction between diagnostic test data and their statistical analysis

    Dopfer, D.D.V.; Maassen, C.B.M.; Achterberg, R.P.; Giessen, van der J.W.B.; Teunis, P.; Buist, W.G.; Molina, V.; Guarnera, E.; Gonzales, M.; Krivokapich, S.; Rodriguez, M.; Peralta, J.L.; Trabattoni, H.; Larrieu, E.; Engel, B.


    To evaluate the usefulness of serological tests applied to monitor Trichinella free herds, Bayesian methodology was used to estimate the diagnostic test parameters: sensitivity, specificity and prevalence in the absence of a Gold Standard test. In the absence of Dutch serum samples for positive pigs

  13. Methodology for vocational psychodiagnostics of senior schoolchildren using information technologies

    Bogdanovskaya, I. M.; Kosheleva, A. N.; Kiselev, P. B.; Davydova, Yu. A.


    The article identifies the role and main problems of vocational psychodiagnostics in modern socio-cultural conditions. It analyzes the potentials of information technologies in vocational psychodiagnostics of senior schoolchildren. The article describes the theoretical and methodological grounds, content and diagnostic potentials of the computerized method in vocational psychodiagnostics. The computerized method includes three blocks of sub-tests to identify intellectual potential, personal qualities, professional interests and values, career orientations, as well as subtests to analyze the specific life experience of senior schoolchildren. The results of diagnostics allow developing an integrated psychodiagnostic conclusion with recommendations. The article contains options of software architecture for the given method.

  14. ORION laser target diagnostics.

    Bentley, C D; Edwards, R D; Andrew, J E; James, S F; Gardner, M D; Comley, A J; Vaughan, K; Horsfield, C J; Rubery, M S; Rothman, S D; Daykin, S; Masoero, S J; Palmer, J B; Meadowcroft, A L; Williams, B M; Gumbrell, E T; Fyrth, J D; Brown, C R D; Hill, M P; Oades, K; Wright, M J; Hood, B A; Kemshall, P


    The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics.

  15. Beamlet laser diagnostics

    Burkhart, S.C.; Behrendt, W.C.; Smith, I.


    Beamlet is instrumented extensively to monitor the performance of the overall laser system and many of its subsystems. Beam diagnostics, installed in key locations, are used to fully characterize the beam during its propagation through the multipass cavity and the laser`s output section. This article describes the diagnostics stations located on Beamlet and discusses the design, calibration, and performance of the Beamlet calorimeters. The authors used Nova`s diagnostics packages to develop the Beamlet design to determine beam energy, spatial profile, temporal profile, and other beam parameters. Technologic improvements within the last several years in controls, charge-coupled device (CCD) cameras, and fast oscilloscopes have allowed the authors to obtain more accurate measurements on the Beamlet laser system. They briefly cover some of these techniques, including a description of their LabVIEW based data acquisition system.

  16. ORION laser target diagnostics

    Bentley, C. D.; Edwards, R. D.; Andrew, J. E.; James, S. F.; Gardner, M. D.; Comley, A. J.; Vaughan, K.; Horsfield, C. J.; Rubery, M. S.; Rothman, S. D.; Daykin, S.; Masoero, S. J.; Palmer, J. B.; Meadowcroft, A. L.; Williams, B. M.; Gumbrell, E. T.; Fyrth, J. D.; Brown, C. R. D.; Hill, M. P.; Oades, K. [Plasma Physics Department, Atomic Weapons Establishment, Aldermaston, Reading, Berkshire RG7 4PR (United Kingdom); and others


    The ORION laser facility is one of the UK's premier laser facilities which became operational at AWE in 2010. Its primary mission is one of stockpile stewardship, ORION will extend the UK's experimental plasma physics capability to the high temperature, high density regime relevant to Atomic Weapons Establishment's (AWE) program. The ORION laser combines ten laser beams operating in the ns regime with two sub ps short pulse chirped pulse amplification beams. This gives the UK a unique combined long pulse/short pulse laser capability which is not only available to AWE personnel but also gives access to our international partners and visiting UK academia. The ORION laser facility is equipped with a comprehensive suite of some 45 diagnostics covering optical, particle, and x-ray diagnostics all able to image the laser target interaction point. This paper focuses on a small selection of these diagnostics.

  17. [Cytology in uropathological diagnostics].

    Gaisa, N T; Lindemann-Docter, K


    Cytology in uropathological diagnostics is mainly performed for oncological purposes. The assessment of malignancy by urothelial cell morphology is therefore decisive; however, cytology is only sensitive enough to detect high-grade tumor cells and the different low-grade tumors cannot be reliably diagnosed. Thus, the four-tier classification system of cytological findings (i.e. negative, atypical cells but significance uncertain, suspicious and positive) refers to high-grade tumor cells only. Furthermore, for valid cytological diagnostics not only the cytological specimen but also clinical information on cystoscopy findings and, if applicable, a biopsy should be evaluated together. In difficult differential diagnostic settings, e.g. differentiation between reactive versus neoplastic atypia or difficult to access lesions in the upper urinary tract, additional fluorescence in situ hybridization of cytological preparations might be helpful. At the moment there are no indications for further immunocytology or additional biomarker tests.

  18. Diagnostics of D.C. Starter Generators While Using Fuzzy Logic Theory

    A. A. Lobaty


    Full Text Available Methodology for sparking control in generator brush contact has been developed on the basis of the proposed fuzzy diagnostic model for ad.c.starter-generator and complex processing of diagnostic data. The paper provides investigation results, namely: dependence of voltage parameters  in an external generator circuit on collector sparking intensity.

  19. Advance care directives

    ... advance directive; Do-not-resuscitate - advance directive; Durable power of attorney - advance care directive; POA - advance care directive; Health care agent - advance care directive; Health care proxy - ...

  20. Team building: conceptual, methodological, and applied considerations.

    Beauchamp, Mark R; McEwan, Desmond; Waldhauser, Katrina J


    Team building has been identified as an important method of improving the psychological climate in which teams operate, as well as overall team functioning. Within the context of sports, team building interventions have consistently been found to result in improvements in team effectiveness. In this paper we review the extant literature on team building in sport, and address a range of conceptual, methodological, and applied considerations that have the potential to advance theory, research, and applied intervention initiatives within the field. This involves expanding the scope of team building strategies that have, to date, primarily focused on developing group cohesion. Copyright © 2017 Elsevier Ltd. All rights reserved.