WorldWideScience

Sample records for adv funct mater

  1. From Virgil to Alma Mater

    Science.gov (United States)

    Spitz, Ellen Handler

    2007-01-01

    For a college to become an alma mater in the hearts of its students, it must show, true to the Latin meaning, the wisdom and comfort of a good foster mother. Since "alma mater" is Latin, and since the study of Latin has waned on all educational levels in both pious and secular milieus, the author wonders whether folks who use that term really know…

  2. Artificial Synapses: Organometal Halide Perovskite Artificial Synapses (Adv. Mater. 28/2016).

    Science.gov (United States)

    Xu, Wentao; Cho, Himchan; Kim, Young-Hoon; Kim, Young-Tae; Wolf, Christoph; Park, Chan-Gyung; Lee, Tae-Woo

    2016-07-01

    A synapse-emulating electronic device based on organometal halide perovskite thin films is described by T.-W. Lee and co-workers on page 5916. The device successfully emulates important characteristics of a biological synapse. This work extends the application of organometal halide perovskites to bioinspired electronic devices, and contributes to the development of neuromorphic electronics. PMID:27442971

  3. Bioprinting: High-Resolution Projection Microstereolithography for Patterning of Neovasculature (Adv. Healthcare Mater. 5/2016).

    Science.gov (United States)

    Raman, Ritu; Bhaduri, Basanta; Mir, Mustafa; Shkumatov, Artem; Lee, Min Kyung; Popescu, Gabriel; Kong, Hyunjoon; Bashir, Rashid

    2016-03-01

    On page 610, R. Bashir and co-workers present a novel projection stereolithographic 3D printer capable of high-resolution patterning of living cells encapsulated within biocompatible hydrogels. Angiogenic cell-encapsulating patches fabricated using this printer can be used to encourage the growth of neovasculature on chick embryos, highlighting one of many possible biomedical applications for this 3D printing technology. PMID:26959420

  4. Carbon Dioxide Capture: Covalent Organic Frameworks for CO2 Capture (Adv. Mater. 15/2016).

    Science.gov (United States)

    Zeng, Yongfei; Zou, Ruqiang; Zhao, Yanli

    2016-04-01

    Covalent organic frameworks (COFs) serve as ideal platforms that can selectively adsorb and separate CO2 from gas mixtures. On page 2855, R. Zou, Y. Zhao, and Y. Zeng highlight research progress in this area, compare recent achievements, and present fundamental principles. Different strategies to improve the CO2 capture capability of COFs are elaborated and the capture performance of representative COFs is analyzed. PMID:27075837

  5. Microfluidics: HYbriD Resonant Acoustics (HYDRA) (Adv. Mater. 10/2016).

    Science.gov (United States)

    Rezk, Amgad R; Tan, James K; Yeo, Leslie Y

    2016-03-01

    On page 1970, L. Y. Yeo and co-workers unravel and elucidate the existence of what they term a surface reflected bulk wave (SRBW), and show, quite counterintuitively, that it is possible to obtain an order-of-magnitude improvement in microfluidic manipulation efficiency, and, in particular, nebulization, through a unique combination of surface and bulk waves without increasing the complexity or cost. PMID:26947942

  6. Osteoanabolic Implants: Osteoanabolic Implant Materials for Orthopedic Treatment (Adv. Healthcare Mater. 14/2016).

    Science.gov (United States)

    Ding, Yun-Fei; Li, Rachel W; Nakai, Masaaki; Majumdar, Trina; Zhang, Dong-Hai; Niinomi, Mitsuo; Birbilis, Nick; Smith, Paul N; Chen, Xiao-Bo

    2016-07-01

    On page 1740, Xiao-Bo Chen and co-workers report an orthopedic implant material specifically designed for osteoporotic bone fractures. A newl strontium phosphate coating applied to a bone-mimicking low elastic titanium alloy with a comparative Young's modulus to that of natural bone results in upregulating the growth of osteoblasts and downregulating that of osteoclasts. Such a promising osteoanabolic effect reveals a suitability in particular for patients who suffer from low quality bone organism and slow fracture recovery. PMID:27436105

  7. Alternative Plasmonic Materials: Alternative Plasmonic Materials: Beyond Gold and Silver (Adv. Mater. 24/2013)

    DEFF Research Database (Denmark)

    Naik, Gururaj V.; Shalaev, Vladimir M.; Boltasseva, Alexandra

    2013-01-01

    new functionalities with applications in sensing, imaging, data storage, novel light sources, energy conversion, quantum optics and others. The cover image depicts a negatively refracting metamaterial device built from novel materials. Image prepared with the help of Dr. Alexander V. Kildishev....

  8. »MATER SEMPER CERTA EST

    OpenAIRE

    Truntič, Tadeja

    2015-01-01

    V diplomskem delu se ukvarjamo z vprašanjem, ali definiciji očetovstva in materinstva, ki izhajata iz rimskega prava, še odražata dejansko stanje v družbi. Obe domnevi sta zakoreninjeni v našem pravnem sistemu z rimskim načelom »mater semper certa est

  9. 17 CFR 279.8 - Form ADV-E, cover page for certificate of accounting of securities and funds in possession or...

    Science.gov (United States)

    2010-04-01

    ... certificate of accounting of securities and funds in possession or custody of an investment adviser. 279.8... PRESCRIBED UNDER THE INVESTMENT ADVISERS ACT OF 1940 § 279.8 Form ADV-E, cover page for certificate of... Federal Register citations affecting Form ADV-E, see the List of CFR Sections Affected, which appears...

  10. Mater semper incertus est: who's your mummy?

    Science.gov (United States)

    D'alton-Harrison, Rita

    2014-01-01

    In English law, the legal term for father has been given a broad definition but the definition of mother remains rooted in biology with the Roman law principle mater semper certa est (the mother is always certain) remaining the norm. However, motherhood may be acquired through giving birth to a child, by donation of gametes or by caring and nurturing a child so that the identity of the mother is no longer certain particularly in the case of surrogacy arrangements. While the law in the UK may automatically recognise the parental status of a commissioning father in a traditional surrogacy arrangement, the parental status of the commissioning mother is not automatically recognised in either a traditional or a gestational surrogacy arrangement. Thus the maxim mater est quam gestation demonstrat (meaning the mother is demonstrated by gestation) is also not approached consistently in the legal interpretation of parentage or motherhood in surrogacy as against other assisted reproduction methods. This raises questions about the extent to which motherhood should be affected by the method of reproduction and whether the sociological and philosophical concept of motherhood should, in the case of surrogacy, give rise to a new principle of 'mater semper incertus est' (the mother is uncertain). This article will argue that the time has come to move away from a legal definition of 'mother' that is based on biology to one that recognises the different forms of motherhood. PMID:24457376

  11. Nanopillars: Large Area Fabrication of Leaning Silicon Nanopillars for Surface Enhanced Raman Spectroscopy (Adv. Mater. 10/2012)

    DEFF Research Database (Denmark)

    Schmidt, Michael Stenbæk; Hübner, Jörg; Boisen, Anja

    2012-01-01

    M. S. Schmidt et al. describe on page OP11 a simple, two-step fabrication process to as-semble flexible, freestanding nanopillars into large-area substrates. These substrates can be made using readily available silicon-processing equipment and are suitable for SERS, having a large, uniform Raman...

  12. Perovskite Solar Cells: High Efficiency Pb-In Binary Metal Perovskite Solar Cells (Adv. Mater. 31/2016).

    Science.gov (United States)

    Wang, Zhao-Kui; Li, Meng; Yang, Ying-Guo; Hu, Yun; Ma, Heng; Gao, Xing-Yu; Liao, Liang-Sheng

    2016-08-01

    On page 6695, X. Y. Gao, L.-S. Liao, and co-workers describe the fabrication of mixed Pb-In perovskite solar cells, using indium (III) chloride and lead (II) chloride with methylammonium iodide. A maximum power conversion efficiency as high as 17.55% is achieved owing to the high quality of the perovskites with multiple ordered crystal orientations. This work demonstrates the possibility of substituting the Pb (II) by using In (III), which opens a broad route to fabricating alloy perovskite solar cells with mitigated ecological impact. PMID:27511533

  13. Pulsed Lasers: Pulsed Lasers Employing Solution-Processed Plasmonic Cu3- x P Colloidal Nanocrystals (Adv. Mater. 18/2016).

    Science.gov (United States)

    Liu, Zeke; Mu, Haoran; Xiao, Si; Wang, Rongbin; Wang, Zhiteng; Wang, Weiwei; Wang, Yongjie; Zhu, Xiangxiang; Lu, Kunyuan; Zhang, Han; Lee, Shuit-Tong; Bao, Qiaoliang; Ma, Wanli

    2016-05-01

    Q. Bao, W. Ma and co-workers demonstrate the usage of plasmonic Cu3-x P colloidal nanocrystals as a new type of tunable saturable absorber for the generation of high-energy pulses in a fiber laser. As described on page 3535, these low-cost, solution-processed, next-generation nonlinear optical materials can be harnessed for applications in signal processing and optical communication. PMID:27151629

  14. Biphasic Metal Films: Intrinsically Stretchable Biphasic (Solid-Liquid) Thin Metal Films (Adv. Mater. 22/2016).

    Science.gov (United States)

    Hirsch, Arthur; Michaud, Hadrien O; Gerratt, Aaron P; de Mulatier, Séverine; Lacour, Stéphanie P

    2016-06-01

    On page 4507, S. P. Lacour and co-workers present highly conductive and stretchable solid-liquid films that are formed by physical vapor deposition of gallium onto an alloying gold layer. The image shows patterns defined by lift-off on an elastomer membrane. The magnified view is a false-color scanning electron microscopy (SEM) image (×5000) of the surface of the films under 50% applied strain, showing the liquid Ga (blue-gray) flowing between the AuGa2 /Ga clusters (gold). PMID:27273441

  15. Nanocarbon Paper: Flexible, High Temperature, Planar Lighting with Large Scale Printable Nanocarbon Paper (Adv. Mater. 23/2016).

    Science.gov (United States)

    Bao, Wenzhong; Pickel, Andrea D; Zhang, Qing; Chen, Yanan; Yao, Yonggang; Wan, Jiayu; Fu, Kun Kelvin; Wang, Yibo; Dai, Jiaqi; Zhu, Hongli; Drew, Dennis; Fuhrer, Michael; Dames, Chris; Hu, Liangbing

    2016-06-01

    On page 4684, C. Dames, L. Hu and co-workers report highly efficient, broadband lighting from printed hybrid nanocarbon structures with carbon nanotubes and reduced graphene oxides. The fast response and excellent stability of the flexible lighting can find applications in a range of emerging applications where the shape and format, as well as being lightweight, are important. PMID:27281044

  16. Optoelectronic Devices: Ultrahigh Mobility in an Organic Semiconductor by Vertical Chain Alignment (Adv. Mater. 12/2016).

    Science.gov (United States)

    Skrypnychuk, Vasyl; Wetzelaer, Gert-Jan A H; Gordiichuk, Pavlo I; Mannsfeld, Stefan C B; Herrmann, Andreas; Toney, Michael F; Barbero, David R

    2016-03-01

    Vertical chain backbone alignment in a semiconducting polythiophene film is illustrated by D. R. Barbero and co-workers on page 2359. The chain alignment enables fast charge transport and ultrahigh mobility, reaching a record high average mobility of 3.1 cm(2) V(-1) s(-1) in the vertical direction, showing that mobilities comparable to those of inorganic materials can be obtained over relatively large distances in polymers through control of the polymer chain orientation. PMID:27001700

  17. Memristors: Direct Observation of Localized Radial Oxygen Migration in Functioning Tantalum Oxide Memristors (Adv. Mater. 14/2016).

    Science.gov (United States)

    Kumar, Suhas; Graves, Catherine E; Strachan, John Paul; Grafals, Emmanuelle Merced; Kilcoyne, Arthur L David; Tyliszczak, Tolek; Weker, Johanna Nelson; Nishi, Yoshio; Williams, R Stanley

    2016-04-01

    As information bits of 0's and 1's are stored in crosspoint tantalum oxide memristors, or resistive random access memory (RRAM) cells, nanoscale-resolution in operando X-ray transmission spectromicroscopy is used by J. P. Strachan and co-workers, as reported on page 2772, to directly observe oxygen migration and clustering, revealing an important operation and failure mechanism of RRAM, a frontrunner technology for next-generation computer memory. PMID:27062166

  18. Polymer Nanowires: Enhanced Photoresponse of Conductive Polymer Nanowires Embedded with Au Nanoparticles (Adv. Mater. 15/2016).

    Science.gov (United States)

    Zhang, Junchang; Zhong, Liubiao; Sun, Yinghui; Li, Anran; Huang, Jing; Meng, Fanben; Chandran, Bevita K; Li, Shuzhou; Jiang, Lin; Chen, Xiaodong

    2016-04-01

    A photoconductor based on composite conductive polymer nanowires embedded with one-dimensional gold nanoparticle chains is developed by L. Jiang, X. Chen, and co-workers, as shown on page 2978. The precise and controllable positioning of the nanoparticle array in the composite photoconductor endues a distinct plasmon-resonance-coupling effect, which plays a critical role in promoting and modulating the photoresponse behavior by the excitation-light wavelength or the power. PMID:27075836

  19. Carbon Nanotubes: Ultrabreathable and Protective Membranes with Sub-5 nm Carbon Nanotube Pores (Adv. Mater. 28/2016).

    Science.gov (United States)

    Bui, Ngoc; Meshot, Eric R; Kim, Sangil; Peña, José; Gibson, Phillip W; Wu, Kuang Jen; Fornasiero, Francesco

    2016-07-01

    A flexible membrane with sub-5 nm single-walled carbon nanotube (SWNT) pores is developed by F. Fornasiero and co-workers, as described on page 5871, for application as a key component of protective, yet breathable fabrics. The SWNTs are shown to enable exceptionally fast transport of water vapor under a concentration driving force. Thus, membranes having SWNTs as moisture-conductive pores feature outstanding breathability and provide a high degree of protection from biological threats by size exclusion. PMID:27442972

  20. 3D Printing: 3D Printing of Shape Memory Polymers for Flexible Electronic Devices (Adv. Mater. 22/2016).

    Science.gov (United States)

    Zarek, Matt; Layani, Michael; Cooperstein, Ido; Sachyani, Ela; Cohn, Daniel; Magdassi, Shlomo

    2016-06-01

    On page 4449, D. Cohn, S. Magdassi, and co-workers describe a general and facile method based on 3D printing of methacrylated macromonomers to fabricate shape-memory objects that can be used in flexible and responsive electrical circuits. Such responsive objects can be used in the fabrication of soft robotics, minimal invasive medical devices, sensors, and wearable electronics. The use of 3D printing overcomes the poor processing characteristics of thermosets and enables complex geometries that are not easily accessible by other techniques. PMID:27273436

  1. Tactile Sensors: MoS2 -Based Tactile Sensor for Electronic Skin Applications (Adv. Mater. 13/2016).

    Science.gov (United States)

    Park, Minhoon; Park, Yong Ju; Chen, Xiang; Park, Yon-Kyu; Kim, Min-Seok; Ahn, Jong-Hyun

    2016-04-01

    A tactile sensor based on a MoS2 strain gauge and a graphene electrode is integrated on a finger tip by M.-S. Kim, J.-H. Ahn, and co-workers, as described on page 2556. The MoS2 and graphene can be conformally attached onto a thumbprint thanks to their outstanding mechanical flexibility. The MoS2 -based tactile sensor, showing excellent sensing properties, is expected to provide great opportunities for electronic-skin and wearable-electronics applications. PMID:27037944

  2. Flexible Electronics: High Pressure Chemical Vapor Deposition of Hydrogenated Amorphous Silicon Films and Solar Cells (Adv. Mater. 28/2016).

    Science.gov (United States)

    He, Rongrui; Day, Todd D; Sparks, Justin R; Sullivan, Nichole F; Badding, John V

    2016-07-01

    On page 5939, J. V. Badding and co-workers describe the unrolling of a flexible hydrogenated amorphous silicon solar cell, deposited by high-pressure chemical vapor deposition. The high-pressure deposition process is represented by the molecules of silane infiltrating the small voids between the rolled up substrate, facilitating plasma-free deposition over a very large area. The high-pressure approach is expected to also find application for 3D nanoarchitectures. PMID:27442970

  3. Organosilica: Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic-Inorganic Hybridization into Frameworks (Adv. Mater. 17/2016).

    Science.gov (United States)

    Chen, Yu; Shi, Jianlin

    2016-05-01

    Organic-inorganic hybrid materials can combine the advantages of organic and inorganic materials, and overcome their drawbacks accordingly. On page 3235, Y. Chen and J. L. Shi review and discuss research progress on the design, synthesis, structure, and composition control of organic-inorganic hybrid mesoporous organosilica nanoparticles (MONs). Extensive applications of MONs in nanotechnology, mainly in nanomedicine, nanocatalysis and nanofabrication are discussed. PMID:27122112

  4. Microspheres: Microfluidic Generation of Monodisperse and Photoreconfigurable Microspheres for Floral Iridescence-Inspired Structural Colorization (Adv. Mater. 26/2016).

    Science.gov (United States)

    Yeo, Seon Ju; Park, Kyung Jin; Guo, Kai; Yoo, Pil J; Lee, Seungwoo

    2016-07-01

    Flowering plants have advanced their colorization strategies to divide incoming white light into spatially sequenced vivid colors, especially by using 2D grating diffractive motifs. On page 5268, P. J. Yoo, S. Lee, and co-workers conceive a new idea for a microfluidic approach to mimic this wonderful biological strategy and its practical application to the color encoding of colloidal particles. PMID:27383025

  5. Wearable Strain Sensors: Carbonized Silk Fabric for Ultrastretchable, Highly Sensitive, and Wearable Strain Sensors (Adv. Mater. 31/2016).

    Science.gov (United States)

    Wang, Chunya; Li, Xiang; Gao, Enlai; Jian, Muqiang; Xia, Kailun; Wang, Qi; Xu, Zhiping; Ren, Tianling; Zhang, Yingying

    2016-08-01

    A novel carbonized plain-weave silk-fabric-based wearable strain sensor is proposed by Y. Y. Zhang and co-workers on page 6640. The sensor can be stretched up to 500% with high sensitivity in a wide strain range and can be assembled into wearable devices for the detection of both large and subtle human activities, showing great potential in human-motion detection and robotics. PMID:27511531

  6. Graphene Films: Synthesis of Graphene Films on Copper Foils by Chemical Vapor Deposition (Adv. Mater. 29/2016).

    Science.gov (United States)

    Li, Xuesong; Colombo, Luigi; Ruoff, Rodney S

    2016-08-01

    Synthesis of graphene films on copper foils is discussed by X. Li, L. Colombo, and R. S. Ruoff on page 6247. Graphene can grow on metal substrates by chemical vapor deposition of hydrocarbons. Hydrocarbons crack on a metal surface, nucleate, grow, and finally merge to form a continuous graphene film. Copper is one of the best candidates for graphene growth due to the advantages of good control over the graphene thickness, the growth of high-quality graphene, and the ease for graphene transfer, and has been widely used for production of large-area graphene films in both academia and industry. PMID:27478085

  7. FunctSNP: an R package to link SNPs to functional knowledge and dbAutoMaker: a suite of Perl scripts to build SNP databases

    Directory of Open Access Journals (Sweden)

    Watson-Haigh Nathan S

    2010-06-01

    Full Text Available Abstract Background Whole genome association studies using highly dense single nucleotide polymorphisms (SNPs are a set of methods to identify DNA markers associated with variation in a particular complex trait of interest. One of the main outcomes from these studies is a subset of statistically significant SNPs. Finding the potential biological functions of such SNPs can be an important step towards further use in human and agricultural populations (e.g., for identifying genes related to susceptibility to complex diseases or genes playing key roles in development or performance. The current challenge is that the information holding the clues to SNP functions is distributed across many different databases. Efficient bioinformatics tools are therefore needed to seamlessly integrate up-to-date functional information on SNPs. Many web services have arisen to meet the challenge but most work only within the framework of human medical research. Although we acknowledge the importance of human research, we identify there is a need for SNP annotation tools for other organisms. Description We introduce an R package called FunctSNP, which is the user interface to custom built species-specific databases. The local relational databases contain SNP data together with functional annotations extracted from online resources. FunctSNP provides a unified bioinformatics resource to link SNPs with functional knowledge (e.g., genes, pathways, ontologies. We also introduce dbAutoMaker, a suite of Perl scripts, which can be scheduled to run periodically to automatically create/update the customised SNP databases. We illustrate the use of FunctSNP with a livestock example, but the approach and software tools presented here can be applied also to human and other organisms. Conclusions Finding the potential functional significance of SNPs is important when further using the outcomes from whole genome association studies. FunctSNP is unique in that it is the only R

  8. "Mater puerorum'. A medieval naming for an enigmatic children's disease.

    Science.gov (United States)

    Kottek, S S

    1981-09-01

    The pediatric clinical entity called "Mater Puerorum' appears first in the latin translation of Rhazes' "Practica Puerorum' and in his "Continens'. His descriptions of the disease could give some likeness either to a diagnosis of night terrors, or of hyperpyretic convulsions, or of a slight form of epilepsy. Mater Puerorum is afterwards described by most pediatric authors till the Renaissance period without much originality. Rhazes being one of their main sources anyway. Mater Puerorum has been considered by Still and Radbill as a synonym for hysterical fits in children. Going back to the Arabic original naming: Ummu's Sibyan, we venture another etymology based on Babylonian-Judeo-Arabic demonology. The "Mother of the Children' could be the female demon Karina--or Lilith--which is said to come to plague the children at night. The naming Mater Puerorum could thus be ascribed to a folklore origin, rather than to hysteria. PMID:7023949

  9. Dura mater is a potential source of Aβ seeds.

    Science.gov (United States)

    Kovacs, Gabor G; Lutz, Mirjam I; Ricken, Gerda; Ströbel, Thomas; Höftberger, Romana; Preusser, Matthias; Regelsberger, Günther; Hönigschnabl, Selma; Reiner, Angelika; Fischer, Peter; Budka, Herbert; Hainfellner, Johannes A

    2016-06-01

    Deposition of amyloid-β (Aβ) in the brain parenchyma and vessels is one of the hallmarks of Alzheimer disease (AD). Recent observations of Aβ deposition in iatrogenic Creutzfeldt-Jakob disease (iCJD) after dural grafting or treatment with pituitary extracts raised concerns whether Aβ is capable of transmitting disease as seen in prion diseases by the disease-associated prion protein. To address this issue, we re-sampled and re-evaluated archival material, including the grafted dura mater of two cases with iCJD (28 and 33-years-old) without mutations in the AβPP, PSEN1 and PSEN2 genes, and carrying ε3/ε3 alleles of the APOE gene. In addition, we evaluated 84 dura mater samples obtained at autopsy (mean age 84.9 ± 0.3) in the community-based VITA study for the presence of Aβ deposition. We show that the dura mater may harbor Aβ deposits (13 %) in the form of cerebral amyloid angiopathy or amorphous aggregates. In both iCJD cases, the grafted dura mater had accumulated Aβ. The morphology and distribution pattern of cerebral Aβ deposition together with the lack of tau pathology distinguishes the Aβ proteinopathy in iCJD from AD, from that seen in young individuals without cognitive decline carrying one or two APOE4 alleles, and from that related to traumatic brain injury. Our novel findings of Aβ deposits in the dura mater, including the grafted dura, and the distinct cerebral Aβ distribution in iCJD support the seeding properties of Aβ. However, in contrast to prion diseases, our study suggests that such Aβ seeding is unable to reproduce the full clinicopathological phenotype of AD. PMID:27016065

  10. Comparative study of ADV and LDA measuring techniques

    Czech Academy of Sciences Publication Activity Database

    Chára, Zdeněk; Matoušek, V.

    Prague: Institute of Hydrodynamics AS CR, v. v. i, 2008 - (Chára, Z.; Bareš, V.), s. 33-36 ISBN 978-80-87117-05-7. [International Symposium on Ultrasonic Doppler Methods for Fluid Mechanics and Fluid Engineering /6./. Prague (CZ), 09.09.2008-11.09.2008] R&D Projects: GA AV ČR IAA200600802 Institutional research plan: CEZ:AV0Z20600510 Keywords : flow measurements * turbulent flow * LDA * ADV Subject RIV: BK - Fluid Dynamics

  11. The 1976 Illini: Sweet Memories of Alma Mater

    OpenAIRE

    Diya Dutt

    1996-01-01

    The purpose of this article is to explore the attitudes of graduates of the class of 1976 from the University of Illinois toward their alma mater over a period of fifteen years. The central question addressed in this article is: How do former students feel about their educational institution as time passes? Early research suggests that students' attachment to their educational institution becomes weaker with the passage of time. This panel data on alumni attitudes towards the academic environ...

  12. Auditing thrombolysis service for stroke at Mater Dei Hospital

    OpenAIRE

    Micallef, Daniel; Mallia, Maria; Borg, Denise; Aquilina, Josanne

    2015-01-01

    Thrombolysis for acute ischaemic stroke was introduced locally in October 2010. In 2012, the practice was audited to analyse the prevalence of inclusion and exclusion criteria for thrombolysis. Data about the local incidence of stroke, demographics and outcome was also obtained. All patients admitted to Mater Dei Hospital with a diagnosis of stroke over an 8 month period were recruited. Standard data collection sheets were used to obtain data. 251 patients were admitted with a confirm...

  13. Dopaminergic receptors in rat dura mater: pharmacological characteristics.

    Science.gov (United States)

    Cavallotti, C; Frati, A; Cavallotti, D; Tranquilli Leali, F M

    2004-03-01

    1. The location and distribution of dopaminergic receptors in rat dura mater was studied by examining several dural zones (vascular, perivascular, intervascular) in different cranial and spinal regions. 2. The pharmacological characteristics and anatomical distribution of dopamine D1- and D2-like receptors sites were investigated using combined pharmacological techniques and immunofluorescent microscopy. 3. Samples of rat dura mater were obtained from 10 adult Wistar rats. On frozen slices, dopaminergic D1 and D2 receptors were stained immunohistochemically using monoclonal antibodies. 4. Inhibition studies were performed using fluorescent and non-fluorescent agonists or antagonists to define the pharmacological specificity of the immunostaining. 5. The greater sensitivity to displacement by amisulpride, bromocryptine, domperidone, haloperidol, raclopride and l-sulpiride than to displacement by N-propyl-nor-apomorphine, quinpirole and clozapine suggests that the immunofluorescent sites observed in these experiments are likely to belong to the dopamine D2 receptor subtype. 6. Our observations provide evidence of the presence of D1 and D2 receptors in the wall of meningeal vessels. The dopaminergic receptors are located in the adventitia, media and intima of dural arteries. Furthermore, the density of receptors is higher in close proximity to arteries and decreases passing from the vascular to the perivascular and intervascular zones. 7. In the rat dura mater, dopamine regulates the meningeal blood vessels and, through this action, dopamine and its receptors can play an important role in the pathogenesis of cephalalgia. PMID:15008964

  14. Solar Cells: Homo-Tandem Polymer Solar Cells with VOC >1.8 V for Efficient PV-Driven Water Splitting (Adv. Mater. 17/2016).

    Science.gov (United States)

    Gao, Yangqin; Le Corre, Vincent M; Gaïtis, Alexandre; Neophytou, Marios; Hamid, Mahmoud Abdul; Takanabe, Kazuhiro; Beaujuge, Pierre M

    2016-05-01

    On page 3366, P. M. Beaujuge and co-workers describe homo-tandem solar cells constructed by stacking identical subcells solution-processed from blends of the wide-bandgap polymer donor PBDTTPD and the fullerene acceptor PCBM, which achieve power conversion efficiencies >8% and open-circuit voltages >1.8 V. The homo-tandem devices provide sufficient voltage to induce the dissociation of water in an electrochemical cell. The authors acknowledge Hyun Ho Hwang (Heno) for developing the artwork. PMID:27122114

  15. Conducting Membranes: Unprecedented Perovskite Oxyfluoride Membranes with High-Efficiency Oxygen Ion Transport Paths for Low-Temperature Oxygen Permeation (Adv. Mater. 18/2016).

    Science.gov (United States)

    Zhu, Jiawei; Liu, Gongping; Liu, Zhengkun; Chu, Zhenyu; Jin, Wanqin; Xu, Nanping

    2016-05-01

    Perovskite oxyfluoride (ABO3-δ Fγ ) membranes for low-temperature oxygen permeation are reported by W. Jin and co-workers. As described on page 3511, using mixed ionic and electronic conducting (MIEC) oxides, this new type of membrane outperforms current state-of-the-art MIEC membranes and satisfies commercial requirements at low temperatures (<923 K). PMID:27151627

  16. Nanotransfer Printing: Inkjet-Assisted Nanotransfer Printing for Large-Scale Integrated Nanopatterns of Various Single-Crystal Organic Materials (Adv. Mater. 15/2016).

    Science.gov (United States)

    Park, Kyung Sun; Baek, Jangmi; Park, Yoonkyung; Lee, Lynn; Lee, Yong-Eun Koo; Kang, Youngjong; Sung, Myung Mo

    2016-04-01

    Inkjet-assisted nanotransfer printing, described by M. M. Sung and co-workers on page 2874, enables monolithic integration of crystalline nanowire arrays with a diverse range of organic materials. Droplets of different molecular ink solutions are transformed into single-crystal organic nanowires within nanoscale channels at selected locations in a nanoscale line-patterned mold. Patterned arrays of various functional nanowires within the mold are then printed directly onto a substrate through the liquid-bridge-mediated transfer process. PMID:27075833

  17. 3D Printing: 3D Printing of Conductive Complex Structures with In Situ Generation of Silver Nanoparticles (Adv. Mater. 19/2016).

    Science.gov (United States)

    Fantino, Erika; Chiappone, Annalisa; Roppolo, Ignazio; Manfredi, Diego; Bongiovanni, Roberta; Pirri, Candido Fabrizio; Calignano, Flaviana

    2016-05-01

    On page 3712, E. Fantino, A. Chiappone, and co-workers fabricate conductive 3D hybrid structures by coupling the photo-reduction of metal precursors with 3D printing technology. The generated structures consist of metal nanoparticles embedded in a polymer matrix shaped into complex multilayered architectures. 3D conductive structures are fabricated with a digital light-processing printer incorporating silver salt into photocurable formulations. PMID:27167030

  18. Cellular Microcultures: Programming Mechanical and Physicochemical Properties of 3D Hydrogel Cellular Microcultures via Direct Ink Writing (Adv. Healthcare Mater. 9/2016).

    Science.gov (United States)

    McCracken, Joselle M; Badea, Adina; Kandel, Mikhail E; Gladman, A Sydney; Wetzel, David J; Popescu, Gabriel; Lewis, Jennifer A; Nuzzo, Ralph G

    2016-05-01

    R. Nuzzo and co-workers show on page 1025 how compositional differences in hydrogels are used to tune their cellular compliance by controlling their polymer mesh properties and subsequent uptake of the protein poly-l-lysine (green spheres in circled inset). The cover image shows pyramid micro-scaffolds prepared using direct ink writing (DIW) that differentially direct fibroblast and preosteoblast growth in 3D, depending on cell motility and surface treatment. PMID:27166616

  19. Osteochondral Regeneration: Tuning Cell Differentiation into a 3D Scaffold Presenting a Pore Shape Gradient for Osteochondral Regeneration (Adv. Healthcare Mater. 14/2016).

    Science.gov (United States)

    Di Luca, Andrea; Lorenzo-Moldero, Ivan; Mota, Carlos; Lepedda, Antonio; Auhl, Dietmar; Van Blitterswijk, Clemens; Moroni, Lorenzo

    2016-07-01

    A combination of human mesenchymal stem cells with additive manufacturing technology for the fabrication of scaffolds with instructive properties is presented by Lorenzo Moroni and co-workers on page 1753. This new fiber deposition pattern allows the generation of pores of different shapes within the same construct. The most rhomboidal pore geometry sustained enhances alkaline phosphatase activity and osteogenic related genes expression with respect to the other gradient zones when the gradient scaffold is cultured in a medium supporting both osteogenic and chondrogenic differentiation. This may contribute to enhance osteochondral regeneration in orthopedic treatments. PMID:27436107

  20. Dye-Sensitized Solar Cells: The Future of Using Earth-Abundant Elements in Counter Electrodes for Dye-Sensitized Solar Cells (Adv. Mater. 20/2016).

    Science.gov (United States)

    Briscoe, Joe; Dunn, Steve

    2016-05-01

    Sustainability is an important concept generating traction in the research community. To be really sustainable the full life cycle of a product needs to be carefully considered. A key aspect of this is using elements that are either readily recycled or accessible in the Earth's biosphere. Jigsawing these materials together in compounds to address our future energy needs represents a great opportunity for the current generation of researchers. On page 3802, S. Dunn and J. Briscoe summarize the performance of a selection of alternative materials to replace platinum in the counter electrodes of dye-sensitized solar cells. PMID:27197641

  1. Electrocatalysts: Guided Evolution of Bulk Metallic Glass Nanostructures: A Platform for Designing 3D Electrocatalytic Surfaces (Adv. Mater. 10/2016).

    Science.gov (United States)

    Doubek, Gustavo; Sekol, Ryan C; Li, Jinyang; Ryu, Won-Hee; Gittleson, Forrest S; Nejati, Siamak; Moy, Eric; Reid, Candy; Carmo, Marcelo; Linardi, Marcelo; Bordeenithikasem, Punnathat; Kinser, Emily; Liu, Yanhui; Tong, Xiao; Osuji, Chinedum O; Schroers, Jan; Mukherjee, Sundeep; Taylor, André D

    2016-03-01

    On page 1940, A. D. Taylor and co-workers demonstrate nanoporous bicontinuous structures using controlled structural evolution of metallic glass. By using techniques such as dealloying, galvanic replacement, and under-potential deposition, bulk-metallic-glass alloys can be pushed beyond their compositional limitations and tuned for a wide variety of interfacial and electrochemical reactions. Examples are illustrated for hydrogen and methanol oxidation, as well as oxygen reduction reactions. PMID:26947938

  2. Field-Effect Transistors: Ultrathin MXene-Micropattern-Based Field-Effect Transistor for Probing Neural Activity (Adv. Mater. 17/2016).

    Science.gov (United States)

    Xu, Bingzhe; Zhu, Minshen; Zhang, Wencong; Zhen, Xu; Pei, Zengxia; Xue, Qi; Zhi, Chunyi; Shi, Peng

    2016-05-01

    A field-effect transistor (FET) based on ultrathin Ti3 C2 -MXene micropatterns is developed by C. Zhi, P. Shi, and co-workers, as described on page 3333. The FET can be utilized for label-free probing of small molecules in typical biological environments, e.g., for fast detection of action potentials in primary neurons. This device is produced with a microcontact printing technique, harnessing the unique advantages for easy fabrication. PMID:27122113

  3. Photoacoustic Imaging: Semiconducting Oligomer Nanoparticles as an Activatable Photoacoustic Probe with Amplified Brightness for In Vivo Imaging of pH (Adv. Mater. 19/2016).

    Science.gov (United States)

    Miao, Qingqing; Lyu, Yan; Ding, Dan; Pu, Kanyi

    2016-05-01

    Despite the great potential of photoacoustic imaging in the life sciences, the development of smart activatable photoacoustic probes remains elusive. On page 3662, K. Pu and co-workers report a facile nanoengineering approach based on semiconducting oligomer nano-particles to develop ratiometric photoacoustic probes with amplified brightness and enhanced sensing capability for accurate photoacoustic mapping of pH in the tumors of living mice. PMID:27167028

  4. pH-Sensing Hydrogel Fibers: Flexible pH-Sensing Hydrogel Fibers for Epidermal Applications (Adv. Healthcare Mater. 6/2016).

    Science.gov (United States)

    Tamayol, Ali; Akbari, Mohsen; Zilberman, Yael; Comotto, Mattia; Lesha, Emal; Serex, Ludovic; Bagherifard, Sara; Chen, Yu; Fu, Guoqing; Ameri, Shideh Kabiri; Ruan, Weitong; Miller, Eric L; Dokmeci, Mehmet R; Sonkusale, Sameer; Khademhosseini, Ali

    2016-03-01

    On page 711 S. Sonkusale, A. Khademhosseini, and co-workers present pH-responsive hydrogel fibers that can be used for long-term monitoring of epidermal wound conditions. pH-responsive dyes are loaded into mesoporous microparticles, which are then embedded into hydrogel fibers developed through microfluidic spinning. The fabricated pH-responsive microfibers are flexible and can create conformal contact with skin. Images of the pH-sensing fibers during real-time pH measurement can be captured with a smart phone camera for convenient readout on-site. PMID:27006158

  5. Sensors: A Highly Sensitive Diketopyrrolopyrrole-Based Ambipolar Transistor for Selective Detection and Discrimination of Xylene Isomers (Adv. Mater. 21/2016).

    Science.gov (United States)

    Wang, Bin; Huynh, Tan-Phat; Wu, Weiwei; Hayek, Naseem; Do, Thu Trang; Cancilla, John C; Torrecilla, Jose S; Nahid, Masrur Morshed; Colwell, John M; Gazit, Oz M; Puniredd, Sreenivasa Reddy; McNeill, Christopher R; Sonar, Prashant; Haick, Hossam

    2016-06-01

    An ambipolar organic field-effect transistor (OFET) based on poly(diketopyrrolopyrrole-terthiophene) (PDPPHD-T3) is shown by P. Sonar, H. Haick, and co-workers on page 4012 to sensitively detect xylene isomers at low to 40 ppm level in multiple sensing features. Combined with pattern-recognition algorithms, a sole ambipolar FET sensor, rather than arrays of sensors, is able to discriminate highly similar xylene structural isomers from each other. PMID:27246920

  6. Aerogels: Aerogels from CdSe/CdS Nanorods with Ultra-long Exciton Lifetimes and High Fluorescence Quantum Yields (Adv. Mater. 40/2015).

    Science.gov (United States)

    Sánchez-Paradinas, Sara; Dorfs, Dirk; Friebe, Sebastian; Freytag, Axel; Wolf, Andreas; Bigall, Nadja C

    2015-10-28

    The fabrication of gels from semiconductor nanoparticles by means of a controlled and optimized destabilization process is investigated by N. C. Bigall and co-workers on page 6152. Aerogels with high photoluminescence quantum yield and ultra-long radiative lifetimes are fabricated from CdSe/CdS seeded nanorods. It is shown that excited electrons can be delocalized within the aerogel monolith while, at the same time, holes stay confined in the CdSe cores. This type of assembly of nanoparticles shows novel properties in comparison to those of the nanoparticle building blocks and of the bulk material. PMID:26487019

  7. Photovoltaics: Highly Efficient Hybrid Photovoltaics Based on Hyperbranched Three-Dimensional TiO 2 Electron Transporting Materials (Adv. Mater. 18/2015)

    KAUST Repository

    Mahmood, Khalid

    2015-05-01

    Solution-processed hybrid photovoltaics are a potentially disruptive third-generation solar cell technology. On page 2859, A. Amassian and co-workers demonstrate that an electrospun hyperbranched electron-transporting material is capable of achieving highly efficient hybrid solar cells across different platforms, including lead-halide perovskites (15.5%) and dye-sensitized solar cells (11.2%).

  8. Stem Cell Bioprinting: Functional 3D Neural Mini-Tissues from Printed Gel-Based Bioink and Human Neural Stem Cells (Adv. Healthcare Mater. 12/2016).

    Science.gov (United States)

    Gu, Qi; Tomaskovic-Crook, Eva; Lozano, Rodrigo; Chen, Yu; Kapsa, Robert M; Zhou, Qi; Wallace, Gordon G; Crook, Jeremy M

    2016-06-01

    On page 1429 G. G. Wallace, J. M. Crook, and co-workers report the first example of fabricating neural tissue by 3D bioprinting human neural stem cells. A novel polysaccharide based bioink preserves stem cell viability and function within the printed construct, enabling self-renewal and differentiation to neurons and supporting neuroglia. Neurons are predominantly GABAergic, establish networks, are spontaneously active, and show a bicuculline induced increased calcium response. PMID:27333401

  9. Phosphorescent OLEDs: Sky-Blue Phosphorescent OLEDs with 34.1% External Quantum Efficiency Using a Low Refractive Index Electron Transporting Layer (Adv. Mater. 24/2016).

    Science.gov (United States)

    Shin, Hyun; Lee, Jeong-Hwan; Moon, Chang-Ki; Huh, Jin-Suk; Sim, Bomi; Kim, Jang-Joo

    2016-06-01

    J.-J. Kim and co-workers achieve highly efficient blue organic light-emitting diodes (OLEDs) using a low-refractive-index layer. As described on page 4920, an external quantum efficiency over 34% is achieved, owing to the low refractive index of the materials. A milepost and a shining entrance of the castle are the metaphor indicating the way to highly efficient blue OLEDs. On the way to the castle, the depicted chemical structures serve as the light-emitting layer. PMID:27311092

  10. Matere z motnjami v duševnem razvoju

    OpenAIRE

    Kolarič, Sandra

    2015-01-01

    S pregledom tuje literature in že opravljenih raziskav v tujini smo v teoretičnem delu magistrske naloge zajeli značilnosti mater z motnjami v duševnem razvoju, dejavnike, ki vplivajo na uspešnost opravljanja materinske vloge, ter pravice oseb z motnjami v duševnem razvoju do starševstva, v povezavi z zakonodajo na slovenskem. Navedli smo vzroke za omejevanje reprodukcije pri ženskah z motnjami v duševnem razvoju in problematiko odvzema skrbništva materam z motnjami v duševnem razvoju nad otr...

  11. Research gaps and technology needs in development of PHM for passive AdvSMR components

    International Nuclear Information System (INIS)

    Advanced small modular reactors (AdvSMRs), which are based on modularization of advanced reactor concepts, may provide a longer-term alternative to traditional light-water reactors and near-term small modular reactors (SMRs), which are based on integral pressurized water reactor (iPWR) concepts. SMRs are challenged economically because of losses in economy of scale; thus, there is increased motivation to reduce the controllable operations and maintenance costs through automation technologies including prognostics health management (PHM) systems. In this regard, PHM systems have the potential to play a vital role in supporting the deployment of AdvSMRs and face several unique challenges with respect to implementation for passive AdvSMR components. This paper presents a summary of a research gaps and technical needs assessment performed for implementation of PHM for passive AdvSMR components

  12. 域名系统运行机制与对ADV-DNS的扩展%DNS MECHANISM AND EXTENDING OF ADV-DNS

    Institute of Scientific and Technical Information of China (English)

    袁兆山; 宋宇; 袁曙

    2001-01-01

    本文分析了目前DNS的解析过程,并基于ADV-DNS,提出一种扩展的ADV-DNS设计模型 .它采用单向解析查询请求,进一步减少了查询的响应延迟,减少了对信道的占用,从而大大的减轻了国际和国内信道的负载.

  13. Autoimmune Oophoritis with Multiple Molecular Targets Mitigated by Transgenic Expression of Mater

    OpenAIRE

    Otsuka, Noriyuki; Tong, Zhi-Bin; Vanevski, Konstantina; Tu, Wei; Cheng, Mickie H.; Nelson, Lawrence M.

    2011-01-01

    Transgenic expression of the MATER autoantigen in antigen-presenting cells significantly mitigates autoimmune oophoritis in mice with implications for diagnosis and tolerance induction in human autoimmune primary ovarian insufficiency.

  14. Cranial Reconstruction following the Removal of an Infected Synthetic Dura Mater Substitute

    Directory of Open Access Journals (Sweden)

    Nobutaka Yoshioka, MD

    2014-04-01

    Conclusions: Staged cranial reconstruction after the removal of an infected synthetic dura mater substitute using an algorithmic approach is feasible and safe, produces satisfactory cosmetic results, and is not associated with any complications.

  15. Mechanical and thermal properties of bacterial-cellulose-fibre-reinforced Mater-Bi® bionanocomposite

    Directory of Open Access Journals (Sweden)

    Hamonangan Nainggolan

    2013-05-01

    Full Text Available The effects of the addition of fibres of bacterial cellulose (FBC to commercial starch of Mater-Bi® have been investigated. FBC produced by cultivating Acetobacter xylinum for 21 days in glucose-based medium were purified by sodium hydroxide 2.5 wt % and sodium hypochlorite 2.5 wt % overnight, consecutively. To obtain water-free BC nanofibres, the pellicles were freeze dried at a pressure of 130 mbar at a cooling rate of 10 °C min−1. Both Mater-Bi and FBC were blended by using a mini twin-screw extruder at 160 °C for 10 min at a rotor speed of 50 rpm. Tensile tests were performed according to ASTM D638 to measure the Young’s modulus, tensile strength and elongation at break. A field emission scanning electron microscope was used to observe the morphology at an accelerating voltage of 10 kV. The crystallinity (Tc and melting temperature (Tm were measured by DSC. Results showed a significant improvement in mechanical and thermal properties in accordance with the addition of FBC into Mater-Bi. FBC is easily incorporated in Mater-Bi matrix and produces homogeneous Mater-Bi/FBC composite. The crystallinity of the Mater-Bi/FBC composites decrease in relation to the increase in the volume fraction of FBC.

  16. Local-Level Prognostics Health Management Systems Framework for Passive AdvSMR Components. Interim Report

    Energy Technology Data Exchange (ETDEWEB)

    Ramuhalli, Pradeep; Roy, Surajit; Hirt, Evelyn H.; Pardini, Allan F.; Jones, Anthony M.; Deibler, John E.; Pitman, Stan G.; Tucker, Joseph C.; Prowant, Matthew S.; Suter, Jonathan D.

    2014-09-12

    This report describes research results to date in support of the integration and demonstration of diagnostics technologies for prototypical AdvSMR passive components (to establish condition indices for monitoring) with model-based prognostics methods. The focus of the PHM methodology and algorithm development in this study is at the localized scale. Multiple localized measurements of material condition (using advanced nondestructive measurement methods), along with available measurements of the stressor environment, enhance the performance of localized diagnostics and prognostics of passive AdvSMR components and systems.

  17. Local-Level Prognostics Health Management Systems Framework for Passive AdvSMR Components. Interim Report

    International Nuclear Information System (INIS)

    This report describes research results to date in support of the integration and demonstration of diagnostics technologies for prototypical AdvSMR passive components (to establish condition indices for monitoring) with model-based prognostics methods. The focus of the PHM methodology and algorithm development in this study is at the localized scale. Multiple localized measurements of material condition (using advanced nondestructive measurement methods), along with available measurements of the stressor environment, enhance the performance of localized diagnostics and prognostics of passive AdvSMR components and systems.

  18. 76 FR 255 - Amendments To Form ADV; Extension of Compliance Date

    Science.gov (United States)

    2011-01-04

    ... treatment for newly registering advisers, we are also persuaded that the limited extension of the compliance... COMMISSION 17 CFR Parts 275 and 279 RIN 3235-AI17 Amendments To Form ADV; Extension of Compliance Date AGENCY: Securities and Exchange Commission. ACTION: Final rule; extension of compliance date. SUMMARY: The...

  19. [The surgical treatment of high myopia with dura mater. The results obtained long term (a clinical study)].

    Science.gov (United States)

    Costin, D; Vancea, P P; Caraman, C; Burlea, M; Antohi, D; Popa, C; Stoian, R

    1990-01-01

    The paper presents the postoperative results obtained by performing scleroplasty with dura-mater in 127 progressive myopic eyes. The authors consider that the homologue dura-mater represents a high quality material to make scleral plasties. The evolution of myopia has ceased in over 60% of the cases. PMID:2100861

  20. 76 FR 36993 - Medical Devices; Neurological Devices; Clarification of Classification for Human Dura Mater...

    Science.gov (United States)

    2011-06-24

    ... CFR Part 882 Medical devices, Neurological devices. Therefore, under the Federal Food, Drug, and... Devices; Neurological Devices; Clarification of Classification for Human Dura Mater; Technical Amendment...). In the Federal Register of November 24, 2004 (69 FR 68612), FDA published a final rule...

  1. Interaction of ionizing radiation with mater; Oddzialywanie promieniowania jonizujacego z materia

    Energy Technology Data Exchange (ETDEWEB)

    Pogocki, D. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland)

    1997-10-01

    The early radiation effects (e.g. excitation, ionization) have been described and compared for different kind of radiation interacting with mater. The mechanism of energy deposition in connection with radiation dose and their spatial distribution has been shown.The commonly used definitions and units in radiation dosimetry have been also reviewed. 4 refs, 4 figs.

  2. Claudia Quinta (Pro Caelio 34 and an altar to Magna Mater

    Directory of Open Access Journals (Sweden)

    Eleanor Winsor Leach

    2010-11-01

    Full Text Available Among the items of sculpture from the Capitoline collection now housed in the Museum of the Power Station Montemartini is a marble relief altar of the Claudian Period (E. Simon's dating dedicated to the mater deorum and the navis salvia and depicting the arrival of the goddess Cybele at Rome by ship. The dedicator is one Claudia Syntyche and the sculpture alludes to the legends attached to a much honored woman of the Claudian family whom Cicero, in his oration pro Caelio brought on stage in a cameo appearance to bolster his case against the controversial contemporary woman Clodia Metelli as one of the accusers of his client M. Caelius Rufus. This paper will consider questions raised by the iconography of the altar with reference to the development of Claudia's legend in Roman mythology and subsequently ask who was this Claudia the dedicator and why did she choose Magna Mater for her vow?

  3. Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016).

    Science.gov (United States)

    Othman, Basmah A; Greenwood, Christina; Abuelela, Ayman F; Bharath, Anil A; Chen, Shu; Theodorou, Ioannis; Douglas, Trevor; Uchida, Maskai; Ryan, Mary; Merzaban, Jasmeen S; Porter, Alexandra E

    2016-06-01

    On page 1310 J. S. Merzaban, A. E. Porter, and co-workers present fluorescently labeled RGD-targeted ZnO nanoparticles (NPs; green) for the targeted delivery of cytotoxic ZnO to integrin αvβ3 receptors expressed on triple negative breast cancer cells. Correlative light-electron microscopy shows that NPs dissolve into ionic Zn(2+) (blue) upon uptake and cause apoptosis (red) with intra-tumor heterogeneity, thereby providing a possible strategy for targeted breast cancer therapy. Cover design by Ivan Gromicho. PMID:27275627

  4. Human Neuron Cultures: Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks (Adv. Healthcare Mater. 15/2016).

    Science.gov (United States)

    Burbulla, Lena F; Beaumont, Kristin G; Mrksich, Milan; Krainc, Dimitri

    2016-08-01

    Dimitri Krainc, Milan Mrksich, and co-workers demonstrate the utility of microcontact printing technology for culturing of human neurons in defined patterns over extended periods of time on page 1894. This approach facilitates studies of neuronal development, cellular trafficking, and related mechanisms that require assessment of individual neurons and neuronal networks. PMID:27511952

  5. Nanowires: A Lattice-Strained Organic Single-Crystal Nanowire Array Fabricated via Solution-Phase Nanograting-Assisted Pattern Transfer for Use in High-Mobility Organic Field-Effect Transistors (Adv. Mater. 16/2016).

    Science.gov (United States)

    Kim, Kyunghun; Rho, Yecheol; Kim, Yebyeol; Kim, Se Hyun; Hahm, Suk Gyu; Park, Chan Eon

    2016-04-01

    S. H. Kim, S. G. Hahm, C. E. Park, and co-workers fabricate a 50 nm-wide organic single-crystalline nanowire array on a centimeter-sized substrate via a facile roll-to-plate process, as described on page 3209. Nanowire growth in a nano-confined space adopts a lattice-strained and single-crystalline packing motif, which can be harnessed for strong intermolecular electronic coupling. Thus, nanowire-based field-effect transistors show extremely high field-effect mobilities up to 9.71 cm(2) V(-1) s(-1) . PMID:27105809

  6. Photothermal Therapy: Cancer Cell Internalization of Gold Nanostars Impacts Their Photothermal Efficiency In Vitro and In Vivo: Toward a Plasmonic Thermal Fingerprint in Tumoral Environment (Adv. Healthcare Mater. 9/2016).

    Science.gov (United States)

    Espinosa, Ana; Silva, Amanda K A; Sánchez-Iglesias, Ana; Grzelczak, Marek; Péchoux, Christine; Desboeufs, Karine; Liz-Marzán, Luis M; Wilhelm, Claire

    2016-05-01

    Because the ultimate target for photothermal therapy is the cancer cell, heating performances must be evaluated intracellularly. On page 1040 C. Wilhelm and team provide the first in vitro and in vivo photothermal measurements in cancer cells with gold nanostars. They demonstrate that once nanostars are internalized within endosomes, heat generation can change significantly. PMID:27166618

  7. Porous Carbon Spheres: Rational Design of Si/SiO2 @Hierarchical Porous Carbon Spheres as Efficient Polysulfide Reservoirs for High-Performance Li-S Battery (Adv. Mater. 16/2016).

    Science.gov (United States)

    Rehman, Sarish; Guo, Shaojun; Hou, Yanglong

    2016-04-01

    S. Guo, Y. Hou, and S. Rehman develop a new class of silicon crosslinked with hierarchical porous carbon spheres usable as an efficient polysulfide reservoir for enhancing the performance of lithium-sulfur batteries. As described on page 3167, the developed hybrid material adsorbs negatively charged polysulfides via both chemical and physical adsorption. Remarkably, the hybrid spheres show a high specific capacity, an excellent rate capability and long cyclability. PMID:27105813

  8. Tumefactive immunoglobulin G4-related disease involving the dura mater: A case report and literature review

    International Nuclear Information System (INIS)

    Immunoglobulin G4 (IgG4)-related disease is a well-known disorder characterized by an inflammatory reaction with an increase in the number of IgG4-positive plasma cells associated with sclerosis. IgG4-related disease often affects the dura mater with a pattern of diffuse thickening when the central nervous system is involved. However, some nodular dural thickening requires discrimination from tumors because of obviously different treatment options. We report of a case of IgG4-related disease with tumefactive dural involvement

  9. Tumefactive immunoglobulin G4-related disease involving the dura mater: A case report and literature review

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Hoon; Lee, Ji Hoon; Ko, Yong; Paik, Seoung Sam; Lee, Young Jun [Dept. of Radiology, Hanyang University Hospital, Seoul (Korea, Republic of); Park, Dong Woo [Dept. of Radiology, Hanyang University Hospital, Seoul (Korea, Republic of)

    2015-08-15

    Immunoglobulin G4 (IgG4)-related disease is a well-known disorder characterized by an inflammatory reaction with an increase in the number of IgG4-positive plasma cells associated with sclerosis. IgG4-related disease often affects the dura mater with a pattern of diffuse thickening when the central nervous system is involved. However, some nodular dural thickening requires discrimination from tumors because of obviously different treatment options. We report of a case of IgG4-related disease with tumefactive dural involvement.

  10. A systematic comparison of the anti-tumoural activity and toxicity of the three Adv-TKs.

    Directory of Open Access Journals (Sweden)

    Qinglei Gao

    Full Text Available Adenovirus 5 vectors, known respectively as, the first generation, second generation and oncolytic adenovirus, have been studied extensively in preclinical and clinical trials. However, hitherto few systemic evaluations of the efficacy and toxicity of these adenoviral vectors that have reflected the vertical history of adenovirus based cancer gene therapy strategies have been undertaken. This study has chosen Adv-TK, the well-established adjuvant treatment in cancer, and compared its efficacy and safety with those of the two newly synthesized oncolytic adenovirus vectors encoding the HSV-TK gene, namely M7 and M8. The results obtained showed that systemic administration of 1×10(8 pfu M7 had an anti-tumour efficacy similar to that of 3×10(10 pfu Adv-TK whilst M8 performed even better. Furthermore, compared to Adv-TK, M7 and M8 reduced the incidence of metastases and substantially prolonged the survival time of the mice xenografted with human orthotopic gastric carcinomas with disseminated metastasis. Even more exciting, however, were the similar toxic and immune safety results obtained from the administration of high doses of M7 or M8 in comparison with Adv-TK in immunocompetent and permissive syrian hamster. The data here exhibit a comprehensive display of the efficacy and safety of the three mutants and provide evidence for the future preclinical use of the M7 and M8 viruses.

  11. EVALUATION OF RANGE ESTIMATES FOR TOYOTA FCHV-ADV UNDER OPEN ROAD DRIVING CONDITIONS

    Energy Technology Data Exchange (ETDEWEB)

    Anton, D.; Wipke, K.; Sprik, S.

    2009-07-10

    The objective of this evaluation was to independently and objectively verify driving ranges of >400 miles announced by Toyota for its new advanced Fuel Cell Hybrid Vehicle (FCHV-adv) utilizing 70 MPa compressed hydrogen. To accomplish this, participants from both Savannah River National Laboratory (SRNL) and the National Renewable Energy Laboratory (NREL) witnessed and participated in a 2-vehicle evaluation with Toyota Motor Engineering & Manufacturing North America, Inc. (TEMA) over a typical open road route for over 11 hours in one day with all relevant data recorded. SRNL and TEMA first entered into discussions of verifying the range of the advanced Toyota Fuel Cell Hybrid Vehicle (FCHV-adv) in August 2008 resulting from reported 400+ mile range by Toyota. After extended negotiations, a CRADA agreement, SRNS CRADA No. CR-04-003, was signed on May 6, 2009. Subsequently, on June 30, 2009 SRNL and NREL participated in an all-day evaluation of the FCHV-adv with TEMA to determine the real-world driving range of this vehicle through on-road driving on an extended round-trip drive between Torrance and San Diego, California. SRNL and NREL observed the vehicles being refueled at Toyota's headquarters the day before the evaluation in Torrance, CA on June 29. At 8:00 AM on June 30, the vehicles departed Torrance north toward downtown Los Angeles, then west to the Pacific Coast Highway, and down to San Diego. After lunch the vehicles retraced their route back to Torrance. The traffic encountered was much heavier than anticipated, causing the vehicles to not return to Torrance until 9 PM. Each vehicle was driven by the same Toyota driver all day, with one SRNL/NREL observer in each vehicle the entire route. Data was logged by Toyota and analyzed by NREL. The maximum range of the FCHV-adv vehicles was calculated to be 431 miles under these driving conditions. This distance was calculated from the actual range of 331.5 miles during over 11 hours driving, plus 99.5 miles

  12. Mucopolysaccharidosis: thickening of dura mater at the craniocervical junction and other CT/MRI findings

    International Nuclear Information System (INIS)

    Cranial CT and/or MRI imaging of 8 patients with mucopolysaccharidosis (MPS) was retrospectively evaluated. Two patients had MPS, IH, 1 had MPS IS, 1 had MPS IVA and 4 had MPS IV. CT and MRI showed thickening of dura mater at the cranio-cervical junction, causing narrowing of the subarachnoid space, in all the patients examined. Spinal cord compression was detected in 4 patients. Other findings were: White matter alterations, mild to severe hydrocephalus, skull dysplasia and odontoid dysplasia. White matter alterations were evident as large areas and as multiple dispersed spots of prolonged T1 and T2 value. Reduced gray/white matter contrast was demonstrated on T2-weighted MRI images. It is important to examine the cranio-cervical junction carefully for thickening of dura mater in all patients with mucopolysaccharidosis examined by CT or MRI, because of the generally progressive clinical course of MPS. In patients with symptomatic cord compression, surgical intervention should be considered. (orig.)

  13. Mucopolysaccharidosis: thickening of dura mater at the craniocervical junction and other CT/MRI findings

    Energy Technology Data Exchange (ETDEWEB)

    Taccone, A. (Dept. of Radiology, G. Gaslini Inst., Genoa (Italy)); Tortori Donati, P. (Section of Neuroradiology, Dept. of Radiology, G. Gaslini Inst., Genoa (Italy)); Marzoli, A. (Dept. of Radiology, G. Gaslini Inst., Genoa (Italy)); Dell' Acqua, A. (Dept. of Radiology, G. Gaslini Inst., Genoa (Italy)); Gatti, R. (3. Pediatric Dept., G. Gaslini Inst., Genoa (Italy)); Leone, D. (Intensive Care Unit, G. Gaslini Inst., Genoa (Italy))

    1993-09-01

    Cranial CT and/or MRI imaging of 8 patients with mucopolysaccharidosis (MPS) was retrospectively evaluated. Two patients had MPS, IH, 1 had MPS IS, 1 had MPS IVA and 4 had MPS IV. CT and MRI showed thickening of dura mater at the cranio-cervical junction, causing narrowing of the subarachnoid space, in all the patients examined. Spinal cord compression was detected in 4 patients. Other findings were: White matter alterations, mild to severe hydrocephalus, skull dysplasia and odontoid dysplasia. White matter alterations were evident as large areas and as multiple dispersed spots of prolonged T1 and T2 value. Reduced gray/white matter contrast was demonstrated on T2-weighted MRI images. It is important to examine the cranio-cervical junction carefully for thickening of dura mater in all patients with mucopolysaccharidosis examined by CT or MRI, because of the generally progressive clinical course of MPS. In patients with symptomatic cord compression, surgical intervention should be considered. (orig.)

  14. MATER - Pianeta Terra-Mare: an interactive and multidisciplinary approach to Geosphere sciences

    Science.gov (United States)

    Piangiamore, Giovanna Lucia; Fanelli, Emanuela; Furia, Stefania; Garau, Daniela; Merlino, Silvia; Musacchio, Gemma; Carla Centineo, Maria

    2016-04-01

    Recent studies demonstrate that Earth and Marine Sciences are not properly treated in scholastic programs and in textbooks are included in a superficial way. These topics are interdisciplinary and experimental (biology, ecology, oceanography and geology) and the recent advance in these fields is strictly linked to technologic improvement. School cannot keep up with the huge advances of knowledge experimented in the last 20 years, also for the lack of didactic laboratories sufficiently updated to support experimental activities. In this context, in 2014-15 three Italian Research Institutes (INGV, ISMAR-CNR and ENEA-CRAM) have decided to support the Unified School District "ISA 10"of Lerici (Liguria, Italy) - comprehensive of kindergartner, primary and middle schools - to develop the project MATER - Pianeta Terra-Mare (Planet Earth and Sea). The acronym MATER (MARe and TERra) has also a gender value, as people involved in the projects were women, mostly researchers and teachers, which have worked side by side with other women belonging to environmental and cultural associations of the territory. This heterogeneous group has a common objective: to promote the diffusion of a scientific culture and to sensitize students from 3 to 14 years towards problems occurring in marine and terrestrial environments, fostering the settlement of a sustainable attitude to the exploitation of natural resources and consciousness to natural hazards, such as earthquakes and floods, quite common in the Ligurian region. MATER has been considered as one of the best projects funded by MIUR (Italian Ministry of Education, University and Research) inside the Dissemination of Scientific and Technological Culture call for the year 2014. Natural hazards (Planet Earth) and the chemical-physical aspects and resources of the marine environment (Planet Sea) were the two modules of the project. Planet Earth developed through Piovono Idee! (Cloudy with a chance of Ideas!), an interactive exhibition on

  15. Muusikapassioon mõttepeeglis. Täna kõlab "Stabat Mater" / Anne Peäske

    Index Scriptorium Estoniae

    Peäske, Anne, 1946-

    2005-01-01

    Arvo Pärdi "Passio" ettekandest 11.sept. Rakvere Kolmainu kirikus. Elmo Lööve, Raivo Palmaru, Jaan Rääts, Toivo Tulev, Aarne Talvik, Ingmar Kurg, Olev Oja ja Eleonora Pärt Arvo Pärdi muusikast. A. Pärdi "Stabat Mater" ansambli Theatre of Voices esituses 14. sept. Rakvere Kolmainu kirikus

  16. Mechanical properties of freeze-dried and irradiated bone chips, fascia lata and dura mater

    International Nuclear Information System (INIS)

    The comparison strengths of freeze-dried and irradiated bone chips such as three-dimensional cortex (3DC) and two-cortico cancellous (2CC) are investigated. The results show that the (3DC) exhibits a higher compression strength (1.2kN cm-2 in deep frozen states. Rehydration of the freeze-dried bone chips after 15 min with normal saline solution restores the strength of materials by 30%. The tensile strengths of fascia lata and dura mater are also studied. A marked decrease of tensile strength is noted in the irradiated and freeze-dried samples, however, reconstitution with normal saline solution restores the tensile strength of the tissues to about 40-56%. (author). 8 refs., 6figs

  17. Mater Nostra: The Anti-blasphemy Message of the Feminist Punk-Prayer

    Directory of Open Access Journals (Sweden)

    Elena Ivanovna Volkova

    2014-12-01

    Full Text Available In this essay I develop a blasphemy counter-discourse arguing that it was ecclesial and state authorities who committed blasphemies, which were condemned by Pussy Riot’s punk-prayer. Thus, the performance in this respect may be interpreted as an anti-blasphemy protest. The blasphemy list includes the collaboration of the church with the authoritarian state, known as heresy of Sergianism; Caesar and Temple idolatry, blasphemy against the Holy Spirit, Virgin Mary and Folly for Christ’s sake. The punk-prayer may be interpreted as a feminine version of the Lord’s Prayer – Mater Nostra. Several corporeal narratives in the background – women’s dress code and rape debates, Virgin Mary’s belt, and its alleged miraculous ability to help women to deliver a baby – may be seen as allegories of feminist vs. patriarchal opposition in Russian religious and political culture.

  18. Modelling the distribution of 90Sr and 137Cs in the Mediterranean Sea (MTPII-MATER)

    International Nuclear Information System (INIS)

    Within the frame of the MTPII-MATER project (MAST), the distribution of 90Sr and 137Cs in the Mediterranean Sea was modelled, as these radionuclides are useful tracers of water circulation. The Mediterranean Sea was divided into 81 boxes, corresponding to 21 regions, taking into account water mass circulation, bathymetry and data availability. Transfer rates were obtained from the MOM model run under MEDMEX conditions. The model was run with realistic inputs, which included weapons global fallout, Chernobyl 137Cs, nuclear industry and river runoff. It was observed that existing data are scarce, especially in the eastern Mediterranean. In general, model predictions agreed well with observations, showing maximum concentrations in surface waters and maxima due to global fallout (137Cs and 90Sr) and to the Chernobyl accident (137Cs only). (author)

  19. A Systematic Comparison of the Anti-Tumoural Activity and Toxicity of the Three Adv-TKs

    OpenAIRE

    Gao, Qinglei; Chen, Caihong; Ji, Teng; Wu, Peng; Han, Zhiqiang; Fang, Haiyan; Li, Fei; Liu, Yi; Hu, Wencheng; Gong, Danni; Zhang, Zeyu; Wang, Shixuan; Zhou, Jianfeng; Ma, Ding

    2014-01-01

    Adenovirus 5 vectors, known respectively as, the first generation, second generation and oncolytic adenovirus, have been studied extensively in preclinical and clinical trials. However, hitherto few systemic evaluations of the efficacy and toxicity of these adenoviral vectors that have reflected the vertical history of adenovirus based cancer gene therapy strategies have been undertaken. This study has chosen Adv-TK, the well-established adjuvant treatment in cancer, and compared its efficacy...

  20. Immune response to dehydrated human dura mater : evaluation in a rabbit model.

    Directory of Open Access Journals (Sweden)

    Kadioglu H

    2002-07-01

    Full Text Available Ninety white hybrid rabbits, each weighing 2.5 to 3.5 kg, were used for this experimental model. Thirty rabbits were used for control, and sixty other rabbits were investigated for the response of host to the dural graft. In all animals, a dural defect, 1 x 1 cm in size, was created on the left parietal area following craniotomy. In the control group the excised free dural piece was then sutured again to the area from which it had been excised before. The dural defect was closed with dehydrated human dura mater (DHD in the half of the rabbits in the group of study, and with autogenous fascia lata (AFL in the other half. After operation, animals in each group were then subjected to one of five different groups comprising of 3,14,30,60 and 90 days follow-up periods. At the end of follow-up periods, histological, parameters such as cellular inflammatory response, development of fibrous tissue, capsulation, and calcification were examined in specimens obtained from the animals. There was no significant difference between AFL and DHD grafts. In conclusion, it seems that DHD is suitable as an ideal dural graft, because the immune response of host to DHD was almost similar to AFL.

  1. Perfluorochemical (PFC liquid enhances recombinant adenovirus vector-mediated viral interleukin-10 (AdvIL-10 expression in rodent lung

    Directory of Open Access Journals (Sweden)

    Zimmerman Jerry J

    2007-05-01

    Full Text Available Abstract Adenovirus and cationic liposome mediated transfer of Interleukin-10 (IL-10, a potent anti-inflammatory cytokine, has been shown to decrease pro-inflammatory cytokine levels and overall lung inflammation in models of lung transplantation and injury. Limitations to current approaches of IL-10 gene therapy include poor vector delivery methods and pro-inflammatory properties of human IL-10 under certain conditions. We hypothesize that using perfluorochemical (PFC liquid to deliver the highly homologous viral IL-10 (vIL-10, which is predominantly anti-inflammatory with minimal pro-inflammatory activities, can potentially be a more effective strategy to combat inflammatory lung diseases. In this study, we compare the use of PFC liquid versus aerosolized method to deliver adenovirus encoding the vIL-10 gene (AdvIL-10 in C57Bl6 mice. Detectable vIL-10 levels were measured from bronchoalveolar lavage fluid and lung homogenates at one, four, ten and thirty days after AdvIL-10. Furthermore, we determined if use of PFC liquid could allow for the use of a lower dose of AdvIL-10 by comparing the levels of detectable vIL-10 at different doses of AdvIL-10 delivered +/- PFC liquid. Results showed that PFC liquid enhanced detectable vIL-10 by up to ten fold and that PFC liquid allowed the use of ten-fold less vector. PFC liquid increased detectable vIL-10 in lung homogenates at all time points; however, the increase in detectable vIL-10 in BAL fluid peaked at four days and was no longer evident by thirty days after intratracheal instillation. In summary, this is the first report utilizing PFC liquid to enhance the delivery of a potentially therapeutic molecule, vIL-10. We believe this strategy can be used to perform future studies on the use of the predominantly anti-inflammatory vIL-10 to treat inflammatory lung diseases.

  2. Update: Creutzfeldt-Jakob disease associated with cadaveric dura mater grafts--Japan, 1978-2008.

    Science.gov (United States)

    2008-10-24

    Creutzfeldt-Jakob disease (CJD) is the most common of the human prion diseases (also known as transmissible spongiform encephalopathies), which, according to the leading hypothesis, are caused by an abnormal protein (i.e., prion) that is able to induce abnormal folding of normal cellular prion proteins. Annual worldwide incidence of these always fatal neurodegenerative diseases is estimated at 0.5-2.0 cases per million population. CJD can occur sporadically, or as a genetic disease, or can be transmitted iatrogenically. In 1996, a new human prion disease, variant CJD (vCJD), was first described in the United Kingdom. This disease was believed to have resulted from human consumption of cattle products contaminated with the prions responsible for bovine spongiform encephalopathy (BSE, commonly known as mad cow disease). That year, in part to check for possible vCJD cases, a national survey was conducted in Japan; 821 CJD cases were identified, including 43 cases associated with receipt of cadaveric dura mater grafts. A single brand of dural graft (Lyodura) produced by a German manufacturer before May 1987 was identified as the most likely vehicle of transmission in all but one case. By 2003, continued surveillance in Japan had identified a total of 97 such cases. Since then, an additional 35 cases have been identified. This report updates previous reports and summarizes the investigation of all 132 cases to date linked to dural grafts. The results suggest that, because of the long incubation period between graft receipt and symptom onset (possibly >24.8 years), continued surveillance in Japan might identify additional CJD cases associated with dural grafts. PMID:18946463

  3. Addendum: Compliant electrostatic chuck based on hairy microstructure (2013 Smart Mater. Struct. 22 015019) and Electrostatic chuck consisting of polymeric electrostatic inductive fibers for handling of objects with rough surfaces (2013 Smart Mater. Struct. 22 095010)

    International Nuclear Information System (INIS)

    The recent papers Saito et al 2013 Smart Mater. Struct. 22 015019 and Dhelika et al 2013 Smart Mater. Struct. 22 095010 described studies of an electrostatic chuck that mimics the structure of gecko-like toes. Earlier work published by the authors and other researchers is cited to further illustrate the origin and motivation of the research. (paper)

  4. Damage Detection in Shear Frame Buildings Using Impulse Response Funct

    Directory of Open Access Journals (Sweden)

    F. Raufi

    2012-06-01

    Full Text Available This research presents a method based on impulse response to determine the time and location of plastic hinge formation by using the recorded responses of the structure in time domain without using complicated transformations. At early stages of earthquake loading, structural systems remain in the elastic phase but when the loading increases, plastic hinges will be formed and will affect the structural response. Determining the location and time of this damage can be very important in decision making process. Most of the previously presented methods aimed at finding the time and location of hinge formation by changing the response space by employing Fourier, Short time Fourier or wavelet transform methods using changes in vibration properties of the system like vibration frequency or vibration modes of the structure. But these methods are not very effective in early warning applications since the vibration properties do not change significantly at the beginning of plastic hinge formation. The obtained results indicate that the proposed method can effectively determine time and location of damage without employing complicated methods and concepts.

  5. Efficacy of Spinal Pia Mater Incision and Laminoplasty Combined with Internal Fixation for Old Spinal Cord Injury

    Institute of Scientific and Technical Information of China (English)

    Gen-long Jiao; Zhi-zhong Li; Ming Tan; Yong-qin Pan; Zhi-gang Zhou

    2012-01-01

    Objective To evaluate the clinical efficacy of incising spinal pia mater to relieve pressure and unilateral open-door laminoplasty with internal screw fixation for treatment of the dated spinal cord injury.Methods From March,2009 to July,2010,16 cases with chronic cervical cord injury underwent spinal dura mater incision and unilateral open-door laminoplasty with internal screw fixation.Nerve functions of pre- and postoperation were evaluated by Frankel classification and the Japanese Orthopaedic Asso ciation (JOA) scale.The improvement rate of JOA score at the indicated time was recorded.Results Postoperative Frankel classification rating of 16 patients improved obviously.JOA scores at the 1st month,3rd month,6th month,and 12th month after surgery were 7.9±2.3,8.5±1.6,8.9±2.1,and 12.4± 2.5,respectively,and significantly increased compared with that prior to surgery (5.5±0.6).At the end of follow-up period,JOA score was significantly higher than that of pre treatment (P<0.05).The recovery was relatively rapid during the first 3 months following the surgery,then entered a platform period.Conclusion It is effective for patients with dated spinal cord injury to undergo spinal decompression and laminoplasty.

  6. Impact of holmium fibre laser radiation (λ = 2.1 μm) on the spinal cord dura mater and adipose tissue

    Science.gov (United States)

    Filatova, S. A.; Kamynin, V. A.; Ryabova, A. V.; Loshchenov, V. B.; Zelenkov, P. V.; Zolotovskii, I. O.; Tsvetkov, V. B.; Kurkov, A. S.

    2015-08-01

    The impact of holmium fibre laser radiation on the samples of biologic tissues (dura mater of spinal cord and adipose tissue with interlayers of muscle) is studied. The experimental results are evaluated by the size of carbonisation and coagulation necrosis zones. The experiment shows that in the case of irradiation of the spinal cord dura mater samples the size of carbonisation and coagulation necrosis zones is insignificant. In the adipose tissue the carbonisation zone is also insignificant, but the region of cellular structure disturbance is large. In the muscle tissue the situation is opposite. The cw laser operation provides clinically acceptable degree of destruction in tissue samples with a minimal carbonisation zone.

  7. Work Domain Analysis of a Predecessor Sodium-cooled Reactor as Baseline for AdvSMR Operational Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Ronald Farris; David Gertman; Jacques Hugo

    2014-03-01

    This report presents the results of the Work Domain Analysis for the Experimental Breeder Reactor (EBR-II). This is part of the phase of the research designed to incorporate Cognitive Work Analysis in the development of a framework for the formalization of an Operational Concept (OpsCon) for Advanced Small Modular Reactors (AdvSMRs). For a new AdvSMR design, information obtained through Cognitive Work Analysis, combined with human performance criteria, can and should be used in during the operational phase of a plant to assess the crew performance aspects associated with identified AdvSMR operational concepts. The main objective of this phase was to develop an analytical and descriptive framework that will help systems and human factors engineers to understand the design and operational requirements of the emerging generation of small, advanced, multi-modular reactors. Using EBR-II as a predecessor to emerging sodium-cooled reactor designs required the application of a method suitable to the structured and systematic analysis of the plant to assist in identifying key features of the work associated with it and to clarify the operational and other constraints. The analysis included the identification and description of operating scenarios that were considered characteristic of this type of nuclear power plant. This is an invaluable aspect of Operational Concept development since it typically reveals aspects of future plant configurations that will have an impact on operations. These include, for example, the effect of core design, different coolants, reactor-to-power conversion unit ratios, modular plant layout, modular versus central control rooms, plant siting, and many more. Multi-modular plants in particular are expected to have a significant impact on overall OpsCon in general, and human performance in particular. To support unconventional modes of operation, the modern control room of a multi-module plant would typically require advanced HSIs that would

  8. The Effects of 910-MHz Electromagnetic Field on Rat Cranial Arachnoid and Dura Mater Collagen. The Axial Periodicity of Collagen Fibrils

    OpenAIRE

    Margaret Tzaphlidou; Evangelos Fotiou

    2004-01-01

    The axial periodicity of rat arachnoid and dura mater collagen fibrils exposed to 910 MHz for 2 h/day for 30 consecutive days was measured by means of image analysis of electron-optical data. Such measurements were compared with those from sham-exposed animals. These measurements reveal that on exposure, the intermolecular interactions during collagen fibril assembly are affected.

  9. Atypical symptoms in patients with cervical spondylosis might be the result of stimulation on the dura mater and spinal cord.

    Science.gov (United States)

    Muheremu, Aikeremujiang; Sun, Yuqing

    2016-06-01

    Patients with cervical spondylosis often present with some atypical symptoms such as vertigo, headache, palpitation, nausea, abdominal discomfort, tinnitus and blurred vision and hypomnesia. Although there are a few hypotheses about the etiology of those symptoms, none of them have provided evidence convincing enough to explain the clinical, pathological and anatomic manifestation of those symptoms. One of the more acceptable explanations is that those symptoms are the results of stimulation of the sympathetic nerves in the posterior longitudinal ligament. The clinical fact that dissection of the posterior longitudinal ligament significantly alleviates the severity of those symptoms seems like an evidence for the validity of this hypothesis. However, recent clinical studies showed that laminoplasty, which has no effect on the posterior longitudinal ligament, can achieve the similar effect. In this paper, we hypothesize that stimulation of the dura mater and spinal cord might be the cause of atypical symptoms in patients with cervical spondylosis. PMID:27142142

  10. A Soft Tissue Chondroma Originating from the Dura Mater of the Lumbar Spinal Canal and it Mimicked a Nerve Sheath Tumor: A Case Report with the MR Imaging

    International Nuclear Information System (INIS)

    Soft tissue chondromas are the benign chondro-osseous tumors of soft tissue that usually occur in the extra-osseous and extra-synovial regions of the extremities. We present here a rare location for a soft tissue chondroma that originated from the dura mater in the lumbar spinal canal, and it mimicked a nerve sheath tumor. We present here the MRI findings and pathologic features of this tumor

  11. Lack of effect of the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine on arteriovenous anastomotic shunting in the dura mater of the pig.

    OpenAIRE

    den Boer, M. O.; Somers, J. A.; Saxena, P R

    1992-01-01

    1. In anaesthetized animals, the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine, reduce carotid arteriovenous anastomotic shunting. Within the carotid vascular bed arteriovenous anastomoses are located, amongst other places in the dura mater, which is a putative site of the pain during a migraine attack. 2. In this investigation, we have localized and measured the arteriovenous shunting within the carotid vascular bed of the pig by using simultaneous intracarotid injections...

  12. Involvement of capsaicin-sensitive afferent nerves in the proteinase-activated receptor 2-mediated vasodilatation in the rat dura mater.

    Science.gov (United States)

    Dux, M; Rosta, J; Sántha, P; Jancsó, G

    2009-07-01

    Neurogenic inflammation of the dura mater encephali has been suggested to contribute to the mechanisms of meningeal nociception and blood flow regulation. Recent findings demonstrated that the rat dura mater is innervated by trigeminal capsaicin-sensitive peptidergic nociceptive afferent nerves which mediate meningeal vascular responses through activation of the transient receptor potential vanilloid type 1 (TRPV1) receptor. The present work explored the functional significance of the capsaicin-sensitive subpopulation of dural afferent nerves via their contribution to the meningeal vascular responses evoked through activation of the proteinase-activated receptor 2 (PAR-2). The vascular responses of the dura mater were studied by laser Doppler flowmetry in a rat open cranial window preparation. Topical applications of trypsin, a PAR-2-activator, or Ser-Leu-Ile-Gly-Arg-Leu-amide (SLIGRL-NH(2)), a selective PAR-2 agonist peptide, resulted in dose-dependent increases in meningeal blood flow. The SLIGRL-NH(2)-induced vasodilatation was significantly reduced following capsaicin-sensitive afferent nerve defunctionalization by prior systemic capsaicin treatment and by pretreatment of the dura mater with the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37). Nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME) an unspecific inhibitor of nitric oxide (NO) production, but not 1-(2-trifluoromethylphenyl) imidazole (TRIM), a neuronal NO synthase inhibitor, also inhibited the vasodilator response to SLIGRL-NH(2). The vasodilator responses elicited by very low concentrations of capsaicin (10 nM) were significantly enhanced by prior application of SLIGRL-NH(2). The present findings demonstrate that activation of the PAR-2 localized on capsaicin-sensitive trigeminal nociceptive afferent nerves induces vasodilatation in the dural vascular bed by mechanisms involving NO and CGRP release. The results indicate that the PAR-2-mediated activation and

  13. Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain.

    Science.gov (United States)

    Lee, Ho-Sung; Kang, Dai-In; Yoon, Seung Zhoo; Ryu, Yeon Hee; Lee, Inhyung; Kim, Hoon-Gi; Lee, Byung-Cheon; Lee, Ki Bog

    2015-07-01

    With chromium-hematoxylin staining, we found evidence for the existence of novel age-dependent network structures in the dura mater of rat brains. Under stereomicroscopy, we noticed that chromium-hematoxylin-stained threadlike structures, which were barely observable in 1-week-old rats, were networked in specific areas of the brain, for example, the lateral lobes and the cerebella, in 4-week-old rats. In 7-week-old rats, those structures were found to have become larger and better networked. With phase contrast microscopy, we found that in 1-week-old rats, chromium-hematoxylin-stained granules were scattered in the same areas of the brain in which the network structures would later be observed in the 4- and 7-week-old rats. Such age-dependent network structures were examined by using optical and transmission electron microscopy, and the following results were obtained. The scattered granules fused into networks with increasing age. Cross-sections of the age-dependent network structures demonstrated heavily-stained basophilic substructures. Transmission electron microscopy revealed the basophilic substructures to be clusters with high electron densities consisting of nanosized particles. We report these data as evidence for the existence of age-dependent network structures in the dura mater, we discuss their putative functions of age-dependent network structures beyond the general concept of the dura mater as a supporting matrix. PMID:26330833

  14. Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain

    Directory of Open Access Journals (Sweden)

    Ho-Sung Lee

    2015-01-01

    Full Text Available With chromium-hematoxylin staining, we found evidence for the existence of novel age-dependent network structures in the dura mater of rat brains. Under stereomicroscopy, we noticed that chromium-hematoxylin-stained threadlike structures, which were barely observable in 1-week-old rats, were networked in specific areas of the brain, for example, the lateral lobes and the cerebella, in 4-week-old rats. In 7-week-old rats, those structures were found to have become larger and better networked. With phase contrast microscopy, we found that in 1-week-old rats, chromium-hematoxylin-stained granules were scattered in the same areas of the brain in which the network structures would later be observed in the 4- and 7-week-old rats. Such age-dependent network structures were examined by using optical and transmission electron microscopy, and the following results were obtained. The scattered granules fused into networks with increasing age. Cross-sections of the age-dependent network structures demonstrated heavily-stained basophilic substructures. Transmission electron microscopy revealed the basophilic substructures to be clusters with high electron densities consisting of nanosized particles. We report these data as evidence for the existence of age-dependent network structures in the dura mater, we discuss their putative functions of age-dependent network structures beyond the general concept of the dura mater as a supporting matrix.

  15. Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain

    Institute of Scientific and Technical Information of China (English)

    Ho-Sung Lee; Dai-In Kang; Seung Zhoo Yoon; Yeon Hee Ryu; Inhyung Lee; Hoon-Gi Kim; Byung-Cheon Lee; Ki Bog Lee

    2015-01-01

    With chromium-hematoxylin staining, we found evidence for the existence of novel age-depen-dent network structures in the dura mater of rat brains. Under stereomicroscopy, we noticed that chromium-hematoxylin-stained threadlike structures, which were barely observable in 1-week-old rats, were networked in specific areas of the brain, for example, the lateral lobes and the cerebella, in 4-week-old rats. In 7-week-old rats, those structures were found to have become larger and better networked. With phase contrast microscopy, we found that in 1-week-old rats, chromium-hematoxylin-stained granules were scattered in the same areas of the brain in which the network structures would later be observed in the 4- and 7-week-old rats. Such age-depen-dent network structures were examined by using optical and transmission electron microscopy, and the following results were obtained. The scattered granules fused into networks with increas-ing age. Cross-sections of the age-dependent network structures demonstrated heavily-stained basophilic substructures. Transmission electron microscopy revealed the basophilic substructures to be clusters with high electron densities consisting of nanosized particles. We report these data as evidence for the existence of age-dependent network structures in the dura mater, we discuss their putative functions of age-dependent network structures beyond the general concept of the dura mater as a supporting matrix.

  16. Pulsed estrogen therapy prevents post-OVX porcine dura mater microvascular network weakening via a PDGF-BB-dependent mechanism.

    Directory of Open Access Journals (Sweden)

    Olga V Glinskii

    Full Text Available In postmenopausal women, estrogen (E2 deficiencies are frequently associated with higher risk of intracranial hemorrhage, increased incidence of stroke, cerebral aneurysm, and decline in cognitive abilities. In younger postpartum women and those using oral contraceptives, perturbations in E2 are associated with higher risk of cerebral venous thrombosis. A number of serious intracranial pathologic conditions linked to E2 deficiencies, such as dural sinus thrombosis, dural fistulae, non-parenchymal intracranial hemorrhages, migraines, and spontaneous cerebrospinal fluid leaks, involve the vessels not of the brain itself, but of the outer fibrous membrane of the brain, the dura mater (DM. The pathogenesis of these disorders remains mysterious and how estrogen regulates structural and functional integrity of DM vasculature is largely unknown. Here, we demonstrate that post ovariectomy (OVX DM vascular remodeling is manifested by microvessel destabilization, capillary rarefaction, increased vascular permeability, and aberrant angio-architecture, and is the result of disrupted E2-regulated PDGF-BB signaling within dura microvasculature. These changes, associated with the reduction in systemic PDGF-BB levels, are not corrected by a flat-dose E2 hormone replacement therapy (HRT, but are largely prevented using HRT schedules mimicking physiological E2 fluctuations. We demonstrate that 1 E2 regulates PDGF-BB production by endothelial cells in a dose-dependent manner and 2 optimization of PDGF-BB levels and induction of robust PDGF-mediated endothelial cell-vascular pericyte interactions require high (estrous E2 concentrations. We conclude that high (estrous levels of E2 are important in controlling PDGF-mediated crosstalk between endothelial cells and pericytes, a fundamental mechanism governing microvessel stability and essential for preserving intracranial homeostasis.

  17. Follicular progesterone concentrations and messenger RNA expression of MATER and OCT-4 in immature bovine oocytes as predictors of developmental competence.

    Science.gov (United States)

    Urrego, R; Herrera-Puerta, E; Chavarria, N A; Camargo, O; Wrenzycki, C; Rodriguez-Osorio, N

    2015-04-15

    The ability of bovine embryos to develop to the blastocyst stage and to implant and generate healthy offspring depends greatly on the competence of the oocyte. Oocyte competence is attributed to its close communication with the follicular environment and to its capacity to synthesize and store substantial amounts of messenger RNA. Higher developmental competence of bovine oocytes has been associated with both the expression of a cohort of developmental genes and the concentration of sex steroids in the follicular fluid. The aim of this study was to identify differences in the expression of FST in cumulus cells and OCT-4 and MATER in oocytes and the influence of the follicular progesterone and follicular estrogen concentration on the competence of bovine oocytes retrieved 30 minutes or 4 hours after slaughter. Cumulus-oocyte complexes (COCs) were left in postmortem ovaries for 30 minutes (group I) or 4 hours (group II) at 30 °C. Aspirated oocytes were then subjected to IVM, IVF, and IVC or were evaluated for MATER and OCT-4 messenger RNA abundance by quantitative real-time polymerase chain reaction. Total RNA was isolated from pools of 100 oocytes for each experimental replicate. Progesterone and estradiol concentration in follicular fluid was evaluated by immunoassay using an IMMULITE 2000 analyzer. Three repeats of in vitro embryo production were performed with a total of 455 (group I) and 470 (group II) COCs. There were no significant differences between the cleavage rates (72 hours postinsemination [hpi]) between both groups (63.5% vs. 69.1%). However, blastocyst (168 hpi) and hatching (216 hpi) rates were higher (P < 0.05) in group II compared with those of group I (21.3% vs. 30.7% and 27.6% vs. 51.5%, respectively). Group II oocytes exhibited the highest MATER and OCT-4 abundance (P < 0.05). Follicular estradiol concentration was not different between both the groups, whereas the progesterone concentration was lower (P ≤ 0.05) in group II follicles. These

  18. Permeability of dura mater

    DEFF Research Database (Denmark)

    Tfelt-Hansen, Peer Carsten

    2011-01-01

    In the wake of cortical spreading depression (CSD) it has been suggested that noxious substances diffuse through the dura with resulting firing of epidural nerves. In my view this is unlikely because there are good reasons to suggest that there must be a dura-brain barrier. Alternatively collater...

  19. Alma Mater: 2014/ Vasara

    OpenAIRE

    Latvijas Universitāte. Preses centrs

    2014-01-01

    Andra Čudare. Studentu taisnības bruņinieks Kirils Solovjovs -- Katrīna Žukova. Zinību lauks – atmiņu laiks -- LU māju noslēpumi atklājās Muzeju naktī -- LU Preses centrs. Zinātne – tas ir forši un radoši -- Sarmīte Rutkovska. Futbols kā tikšanās vieta -- LU Zinātnes un tehnikas vēstures muzejs, LU Preses centrs. Fotostāsts. Studentu mode cauri laikiem -- Laine Dobulāne. Atjauno modernākās ērģeles Latvijā -- LU Preses centrs. Praktiķi dalās pieredzē ar topošajiem kolēģiem -- LU Preses centrs...

  20. The Thermal Stability of Tertiary Pyridine Resin for the Application to Multi-functional Reprocessing Process - Adv.-ORIENT Cycle Development

    International Nuclear Information System (INIS)

    As part of 'Adv.-ORIENT' (Advanced Optimization by Recycling Instructive Elements) cycle technologies which aim to develop new fuel cycle based on FBR (Fast Breeder Reactor), the fundamental thermochemical properties of tertiary pyridine resin (TPR) and its mixtures with methanol/HCl and HNO3 were investigated and heating tests on gram scale with TPR/methanol/HNO3 were carried out in order to evaluate the thermal stability of TPR and to determine the conditions necessary to avoid runaway reactions. It was found that TPR with HCl was thermally stable. Evident thermal decomposition peaks were identified with TPR in the presence of concentrated HNO3. No specific effect was observed for methanol involving. However, it was considered that the rapidly exothermic reaction can be controlled by heating temperature. (authors)

  1. Biochemistry of the normal dura mater of the human brain determination of water, sodium, potassium, calcium, phosphorus, magnesium, copper, iron, sulfur and nitrogen contents

    Directory of Open Access Journals (Sweden)

    Horacio M. Canelas

    1969-06-01

    Full Text Available The concentrations of water, sodium, potassium, calcium, phosphorus, magnesium, copper, iron, sulfur, and nitrogen were determined in samples of apparently normal dura mater removed from 18 subjects recently dead by craniocerebral trauma. The average concentrations expressed in dry weight were: water 79.55 g/100 g ± 2.52; sodium 1.63 mequiv/100 g ±0.27; potassium 3.68 mequiv/100 g ± 0.66; calcium 119.84 mg/100 g ± 107.40; phosphorus 68.2 mg/100 g ± 34.5; magnesium 0.61 mequiv/100 g ± 0.37; copper 249.8 /xg/100 g ± 109.4; iron 0.82 mg/100 g ± 0.28; sulfur 490.7 mg/100 g ± 22.5; nitrogen 3.33 g/100 g ± 0.17.

  2. Pathogenic and clinical characteristics of hepatitis B virus (HBV) pre-existing mutations related to adefovir dipivoxil (ADV) among ADV treatment-naive patients with chronic HBV infection%阿德福韦酯相关位点预存病毒变异的病原学及临床特征分析

    Institute of Scientific and Technical Information of China (English)

    毛海芳; 胡爱荣; 蒋素文; 丁世雄; 翁彭剑; 胡耀仁; 梁晓岳

    2013-01-01

    Objective To understand the pathogenic and clinical characteristics of HBV pre-existing mutations related to ADV among ADV treatment-naive patients with chronic HBV infection. Methods The gene re-sistance mutations of HBV P region in 211 ADV treatment-naive patients were analyzed by gene sequencing, meanwhile the HBV genotypes as well as HBV serum markers and HBV DNA levels were also determined. All patients were divided into pre-existing mutation group and non-mutation group based on the above data. Results Out of 211 patients, 9 were found to have pre-existing mutations related to ADV and 4 of them had ill-formed usage of other antiviral drugs except for ADV. rtN238T mutation was found to be the dominant one (44. 44%) , and multi-sites mutation (55. 56%) and mutation co-existence with wild strain (88. 89%) were al-so popular. The constituent ratios of males and end-stage liver diseases in pre-existing mutation group were higher than those in non-mutation group (P = 0. 013, <0. 001) . The average age of patients was 45. 9± 10. 5 years in pre-existing mutation group and 35. 6±10. 2 years old in non-mutation group (t=2. 978, P = 0. 003) . There were no statistically significant differences of constituent ratio of HBeAg, HBV genotypes and HBV DNA levels between the two groups. Conclusions There may be .some cases with pre-existing muta-tions in ADV treatment-naive patients, and these pre-existing mutations may be related to ill-formed usage of antiviral drugs. Male patients and patients with longer history of HBV infection are more likely to have pre-ex-ist 年个 mutations. It is important for patients to accept normative antiviral treatment in order to prevent re-sistance and avoid salvage therapy.%目的 了解慢性乙型肝炎病毒(HBV)感染者抗病毒治疗前阿德福韦酯(ADV)相关位点预存病毒变异的发生情况以及临床特点.方法 采用基因测序的方法对211例拟行抗病毒治疗的慢性HBV感染者的血清样本进行P区病

  3. Field observations of SPM using ADV, ADP, and OBS in a shallow estuarine system with low SPM concentration—Vitória Bay, SE Brazil

    Science.gov (United States)

    Moura, Marcel G.; Quaresma, Valeria S.; Bastos, Alex C.; Veronez, Paulo

    2011-03-01

    The present study investigated direct and indirect methods using optical and acoustic instruments for the acquisition of information required to estimate the concentration of suspended particulate matter (SPM) in Vitória Bay, a shallow estuarine system in SE Brazil. The aim was to calibrate and compare the use of different instruments (OBS, ADP, and ADV) to estimate SPM concentration in the water column and near the bed. Concentration was determined by correlating filtered water samples with the optical and acoustic measurements. In general, the methodology proved tenable for the chosen shallow estuarine environment with low SPM concentration (<60 mg/L). Pearson's coefficient ranged from 0.75 to 0.85, when correlating measurements taken at three sampled depths. Differences in the correlation coefficient values showed that calibration at three depths (near the bed, mid-water column, and near the surface) was more effective than for surface samples alone, even in shallow (˜3 m deep) water. When calibration was attempted for concentration in the entire water column with samples at just one elevation, the correlation value was very low, thus increasing the error in estimating the SPM concentration.

  4. An integrated system for managing multidisciplinary oceanographic data collected in the Mediterranean Sea during the basin-scale research project EU/MAST-MATER (1996 2000)

    Science.gov (United States)

    Maillard, C.; Balopoulos, E.; Giorgetti, A.; Fichaut, M.; Iona, A.; Larour, M.; Latrouite, A.; Manca, B.; Maudire, G.; Nicolas, P.; Sanchez-Cabeza, J.-A.

    2002-06-01

    An advanced computer and communication technology was used to develop an integrated system and software tools for managing a great diversity of oceanographic data collected in the Mediterranean Sea during 1996-2000. Data were obtained during 108 sea cruises, carried out within the framework of the large-scale international research project MATER (mass transfer and ecosystem response), which was financially supported by the Marine Science and Technology (MAST) Programme of the European Union (EU). Data collection involved the active participation of various research vessels and personnel coming from 58 different laboratories of 13 countries. Data formatting as well as automatic and visual data quality controls were implemented using internationally accepted standards and procedures. Various data inventories and meta-data information, accessible through the World Wide Web (WWW), are made available to the user community. A database was developed, which, along with meta-data and other data relevant to the project information, is made available to the user community in the form of a CD-ROM. The database consists of 5861 vertical profiles and 842 time series of basic physical and biogeochemical parameters collected in the seawater column as well as biogeochemical parameters from the analysis of 70 sediment cores. Furthermore, it includes 67 cruise data files of nonstandard additional biological and atmospheric parameters.

  5. 骨髓间充质干细胞修复硬脊膜缺损的应用研究%Application of bone marrow mesenchymal stem cells to repair defects in spinal dura mater

    Institute of Scientific and Technical Information of China (English)

    夏震; 郭开今; 邓斌; 蒋允昌; 章浩杰; 冯虎

    2014-01-01

    Objective To explore the feasibility and effectiveness of bone marrow mesenchymal stem cells ( BM-SCs) in repair of defects in rabbit dura mater .Methods The bone marrow was extracted from the ilium of rabbits . Then, BMSCs were isolated and purified through by density gradient centrifugation and adherence screening method before seeded onto artificial spinal dura mater .Sixteen rabbits were randomly divided into group A and group B , with eight in each group.An epidural damage model was made by removal of the L 4 vertebral plate.Then, artificial spinal dura mater was padded into the gap in group A , while artificial spinal dura mater combined with bone marrow mesenchymal stem cells was padded into the gap in group B .The animals were sacrificed 30 days after operation and the tissue within the re-paired area was collected for gross pathological and histological observation .Cell density was also calculated .Results Large amounts of fibroblasts and collagen fibers were observed in group B .Cell density in group B was higher than that of group A (P<0.05).Conclusion Bone marrow mesenchymal stem cells can promote the restoration of the dura mater .%目的:探讨骨髓间充质干细胞( BMSC )修复兔破损硬脊膜的可行性和有效性。方法穿刺抽取日本大耳白兔髂后上棘骨髓,分离BMSC,采用贴壁筛选法对分离的BMSC进行纯化,接种于人工硬脊膜上。16只日本大耳白兔,随机分成A组、B组,每组8只,制作L4椎板切除硬脊膜破损模型, A组人工硬脊膜敷贴裂口处, B组骨髓间充质干细复合人工硬脊膜敷贴裂口处。术后30天处死动物,取修复区域的组织行大体观察和病理学观察,并对成纤维细胞密度进行分析。结果 B组成纤维细胞与胶原纤维丰富,细胞密度高于A组( P<0.05)。结论骨髓间充质干细胞可以促进硬脊膜修复。

  6. Distinctive properties of plaque-type dura mater graft-associated Creutzfeldt-Jakob disease in cell-protein misfolding cyclic amplification.

    Science.gov (United States)

    Takeuchi, Atsuko; Kobayashi, Atsushi; Parchi, Piero; Yamada, Masahito; Morita, Masanori; Uno, Shusei; Kitamoto, Tetsuyuki

    2016-05-01

    There are two distinct subtypes of dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) with methionine homozygosity at codon 129 of the PRNP gene. The majority of cases is represented by a non-plaque-type (np-dCJD) resembling sporadic CJD (sCJD)-MM1 or -MV1, while the minority by a plaque-type (p-dCJD). p-dCJD shows distinctive phenotypic features, namely numerous kuru plaques and an abnormal isoform of prion protein (PrP(Sc)) intermediate in size between types 1 and 2. Transmission studies have shown that the unusual phenotypic features of p-dCJD are linked to the V2 prion strain that is associated with sCJD subtypes VV2 or -MV2. In this study, we applied protein misfolding cyclic amplification (PMCA) using recombinant human prion protein as a substrate and demonstrated that p-dCJD prions show amplification features that are distinct from those of np-dCJD. Although no amplification of np-dCJD prions was observed with either 129 M or 129 V substrate, p-dCJD prions were drastically amplified with the 129 V substrates, despite the PRNP codon 129 incompatibility between seed and substrate. Moreover, by using a type 2 PrP(Sc)-specific antibody not recognizing PrP(Sc) in p-dCJD, we found that type 2 products are generated de novo from p-dCJD prions during PMCA with the 129 V substrates. These findings suggest that our cell-PMCA is a useful tool for easily and rapidly identifying acquired CJD associated with the transmission of the V2 CJD strain to codon 129 methionine homozygotes, based on the preference for the 129 V substrate and the type of the amplified products. PMID:26878132

  7. Microarray analysis of gene expression after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats

    Institute of Scientific and Technical Information of China (English)

    Jiang Lei; Dong Zhao; Li Fengpeng; Liu Ruozhuo; Qiu Enchao; Wang Xiaolin; Yu Shengyuan

    2014-01-01

    Background The molecular and cellular origins of migraine headache are among the most complex problems in contemporary neurology.Up to now the pathogenesis of migraine still remains unclearly defined.The objective of this study was to explore new factors that may be related to the mechanism of migraine.Methods The present study performed a comprehensive analysis of gene expression in the trigeminal nucleus caudalis induced by electrical stimulation of dura mater surrounding the superior sagittal sinus in conscious rats using microarray analysis followed by quantitative real-time reverse-transcribed polymerase chain reaction (qRT-PCR) verification.Student's two sample t-test was employed when two groups were compared.A P value <0.05 was considered to be statistically significant.Results Comparing the placebo and the electrical stimulation groups,40 genes were determined to be significantly differentially expressed.These significantly differentially expressed genes were involved in many pathways,including transporter activity,tryptophan metabolism,G protein signaling,kinase activity,actin binding,signal transducer activity,anion transport,protein folding,enzyme inhibitor activity,coenzyme metabolism,binding,ion transport,cell adhesion,metal ion transport,oxidoreductase activity,mitochondrion function,and others.Most of the genes were involved in more than 2 pathways.Of particular interest is the up-regulation of Phactr3 and Akap5 and the down-regulation of Kdr.Conclusion These findings may provide important clues for a better understanding of the molecular mechanism of migraine.

  8. Synthesis of CdS nanowire networks and their optical and electrical properties

    International Nuclear Information System (INIS)

    High quality single-crystal CdS nanowire (NW) networks have been synthesized on Si(111) substrates via the chemical vapour deposition method. X-ray diffraction and selected area electron diffraction show that the NWs in the networks grow along the directions and their (0001) crystal planes are parallel to the Si(111) substrates. Room-temperature photoluminescence (PL) spectra of single CdS NWs in the networks are dominated by a near-band-edge emission and free from deep-level defect emissions. The PLs resulting from free-exciton and bound-exciton recombinations are detected at 77 K. The results of the electrical transport measurement on the CdS NW networks show that the current can flow through different NWs via the cross-junctions. The resistivity, electron concentration and electron mobility of single NWs in the networks are estimated by fitting the I-V curves measured on single NWs with the metal-semiconductor-metal model suggested by Zhang et al (2006 Appl. Phys. Lett. 88 073102; 2007 Adv. Funct. Mater. at press)

  9. Bibliographical review on the teaching and learning of cell structure and functing

    OpenAIRE

    María Luz Rodríguez Palmero

    1997-01-01

    Bibliographic review with the aim of determing the role played by the knowledge of the cell in learning Biology. Nineteen papers have been considered under the following criteria : subject, sample, instrument, results and relevant conclusions. It also comprises eight bibliographic reviews on the subject and conclusions of Biology concepts learning. The information which has been obtained has been presented with graphics and an epistemological V which summarizes it.

  10. Alma mater eksponeerib / Kaire Nurk

    Index Scriptorium Estoniae

    Nurk, Kaire, 1960-

    2004-01-01

    Tiit Pääsukese "Maalid" Tartu Ülikooli Y-galeriis 2.-21. III, galeriist (galerist Margus Kiis). Näitus "Põletatud savi - antiigist tänapäevani" TÜ kunstimuuseumis (Berliini Antikensammlungi antiikvaasid, 17 eesti keraamiku antiigiteemalised taiesed) kuni 30. III, kuraatorid Inge Kukk, Airi Ligi, kujundaja Silver Vahtre

  11. O problema da classificação do item “onde”: advérbio ou pronome? = The problematic classification of the term where. is it an adverb or a pronoun?

    Directory of Open Access Journals (Sweden)

    Adriana dos Santos Souza

    2010-07-01

    Full Text Available Muitos trabalhos têm sido desenvolvidos a partir do item “onde”, dada a diversidade de usos que a ele são atribuídos. Face a esse fato, deparamo-nos ainda com as discussões acerca da classe gramatical na qual, tradicionalmente, insere-se o referido termo: os advérbios. Discutem-se aqui alguns pontos importantes sobre eles, como a definição tradicional, as questões históricas que permeiam essa conceituação, os problemas associados a essa tradição, além de serem apresentadas outras definições que se pautam em estudos de caráter funcionalista. A partir desse esboço, apresentamos a literatura relacionada ao onde, descrevendo a origem, as possíveis classificações morfossintáticas (advérbio/pronome e algumas acepções a ele atribuídas por diversos pesquisadores, a partir de pesquisas comcorpora de sincronias distintas.Owing to different uses assigned to the term, where has been the object of several studies. Investigations have also been made on issues with regard to its grammatical class, the adverbs, in which traditionally the term has been inserted. Important issues are raised on the adverbs, among which the traditional definition, the historical issues that pervade its concept, the problems associated with this tradition and other definitions based on functional studies. The literature related to the term where is provided, coupled to a description of its origin, its possible morphological and syntactical classifications (adverb/pronoun and some stances attributed to it by researchers as from discussions with distinct synchronies corpora.

  12. Retraction notice to “Magnetic properties of iron-based soft magnetic composites with MgO coating obtained by sol-gel method” [J. Magn. Magn. Mater. 322 (7) (2010) 808-813

    Science.gov (United States)

    Taghvaei, A. H.; Ebrahimi, A.; Ghaffari, M.; Janghorban, K.

    2012-09-01

    This article has been retracted at the request of the Editor-in-Chief. The authors have plagiarized part of a paper that had already appeared in “Properties of Soft magnetic composite with Evaporated MgO Insulation Coating for low Iron Loss” authored by G. Uozumi et al., published in Mater. Sci. Forum 534-536 (2007) 1361-1364, http://dx.doi.org/10.4028/www.scientific.net/MSF.534-536.1361. One of the conditions of submission of a paper for publication is that authors declare explicitly that their work is original and has not appeared in a publication elsewhere. Re-use of any data should be appropriately cited. As such this article represents a severe abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

  13. Experimental Study of the Protrusion of the Dura Mater at Skull-base Defects%颅底骨缺损硬脑膜膨出的实验研究

    Institute of Scientific and Technical Information of China (English)

    宋冬雷; 丁祖荣; 周良辅; 李士其

    2001-01-01

    目的:建立颅底缺损硬脑膜膨出量评估公式,为临床颅底缺损重建提供科学实验依据。方法:通过力学蠕变挠度分析,得到预计硬脑膜膨出量的力学计算公式,设计相应的力学模拟实验和动物实验加以验证。结果:力学模拟实验及动物实验证明通过力学分析得到的公式是基本正确的。结论:我们建立的颅底骨缺损硬脑膜膨出量评估公式,可以用来预测硬脑膜及其替代物膨出量的动态变化。%Aim:To establish the biomechanical assessment formula that predicts protrusion ofthe dura mater at the cranial base bone defect, and provide scientific experimental basis for cranial base defect reconstruction. Methods: The biomeehanical formula is established by using the creep reflecton analysis and validated by the simulated test and animal expeximents. Results: The simulated test and animal experiments reveal that biomechanical formula is right. Conclusion: The biomechanical formula can be used to predict the dynamic change of protrusion of the dura mater as well as its substitutes at different sizes of cranial base bone defects.

  14. Clinical analysis of 91 cases with hepatitis B after discontinuation of different doses of ADV%不同剂量阿德福韦酯停药后肝炎91例临床分析

    Institute of Scientific and Technical Information of China (English)

    顾生旺; 赵兵; 刘欢; 蒋兆荣; 焦峰

    2013-01-01

    目的:探讨不同剂量ADV治疗CHB患者停药后肝炎复发率与停药原因。方法对635例不同剂量ADV治疗的CHB患者定期检测肝功能、HBV DNA并建立Excel随访系统,比较各组停药后肝炎发生率。结果半量组停药后肝炎发生率为14.2%,常量组停药后肝炎发生率为13.7%,1.5倍量组停药后肝炎发生率为12.5%,2倍量组停药后肝炎发生率为16.2%,联合治疗组停药后肝炎发生率为19.3%;各组累计停药肝炎91例(14.3%),停药相关肝癌2例(0.3%),重症肝炎3例(0.5%),死亡4例(0.6%)。结论停药主要原因为包括效果不满意46.1%、经济困难21.9%,抗病毒认知度不够13.1%。2倍量组与联合治疗组停药肝炎发生率均高于常量组,差异均无统计学意义(P均>0.05)。加强健康教育与医患沟通,提高疾病认知度、定期检查并不断优化治疗是防止停药肝炎及相关事件的关键。%Objective To explore the different dosages of ADV for the treatment of chronic hepatitis B (CHB) patients after drug withdrawal hepatitis incidence and reason for discontinuation. Methods Total of 635 cases of different dosages of ADV therapy in patients with CHB liver meritorious service is regular detection, HBV DNA and build Excellfollow-up system, compare each withdrawal hepatitis incidence. Results Half a set of drug withdrawal hepatitis 14.2%, constant withdrawal hepatitis was 13.7%, 1.5-2 times the amount of drug withdrawal hepatitis group 12.5%-16.2%, united group of drug withdrawal hepatitis, 19.3%; Each group accumulative total withdrawal hepatitis, 91 cases (14.3%), drug cessation related hepatocellular carcinoma 2 cases, 3 cases of severe hepatitis, 4 cases died. Conclusions Main reason for the discontinuation is effect is not satisifed with 46.1%and 21.9%economic dififculties, 13.1%antiviral awareness is not enough. The drug withdrawal hepatitis incidence of 2 times the amount group and combined

  15. Collagen-inspired self-assembling materals

    OpenAIRE

    Skrzeszewska, P.J.

    2011-01-01

      The rapid increase of the quality of life together with the progress of medical science asks for the development of new, tuneable and controllable materials. For the same reason, materials used for biomedical applications have to be increasingly biocompatible, biodegradable and biofunctional. Most of the available systems, however, lack one property or the other. For example, conventional animal-derived gelatin that is often used in biomedicine, is susceptible to a risk of contaminatio...

  16. Collagen-inspired self-assembling materals

    NARCIS (Netherlands)

    Skrzeszewska, P.J.

    2011-01-01

      The rapid increase of the quality of life together with the progress of medical science asks for the development of new, tuneable and controllable materials. For the same reason, materials used for biomedical applications have to be increasingly biocompatible, biodegradable and biofunctional

  17. Otrokova navezanost na mater in discipliniranje otroka:

    OpenAIRE

    Cugmas, Zlatka

    1998-01-01

    This study examined relations between attachment security, maternal discipline, and emerging internalization in 124 children attending a school entry programme, the first, the third or the fourth year at primary school. The quality of the child's attachment to the mother was determined using two estimation scales which covered the child's behaviour towards the mother in stressful situations. The study mostly supported the link between gentle, psychologically oriented discipline (opposite of p...

  18. Alma mater ootab tagasi / Triin Tabur

    Index Scriptorium Estoniae

    Tabur, Triin

    2011-01-01

    Tartu Ülikooli arstiteaduskonna ja sotsiaalministeeriumi koostööna käivitunud täiendusõppeprogrammist, mille eesmärgiks on arstiteaduse põhiõppe lõpetanud, ent kliinilisest tööst eemaldunud arstid raviasutustesse tagasi tuua

  19. Biochemistry of the normal dura mater of the human brain determination of water, sodium, potassium, calcium, phosphorus, magnesium, copper, iron, sulfur and nitrogen contents Estudo bioquímico da dura mater normal do cérebro humano: conteúdo de água, sódio, potássio, cálcio, fósforo, magnésio, cobre ferro, enxôfre e nitrogênio

    Directory of Open Access Journals (Sweden)

    Horacio M. Canelas

    1969-06-01

    Full Text Available The concentrations of water, sodium, potassium, calcium, phosphorus, magnesium, copper, iron, sulfur, and nitrogen were determined in samples of apparently normal dura mater removed from 18 subjects recently dead by craniocerebral trauma. The average concentrations expressed in dry weight were: water 79.55 g/100 g ± 2.52; sodium 1.63 mequiv/100 g ±0.27; potassium 3.68 mequiv/100 g ± 0.66; calcium 119.84 mg/100 g ± 107.40; phosphorus 68.2 mg/100 g ± 34.5; magnesium 0.61 mequiv/100 g ± 0.37; copper 249.8 /xg/100 g ± 109.4; iron 0.82 mg/100 g ± 0.28; sulfur 490.7 mg/100 g ± 22.5; nitrogen 3.33 g/100 g ± 0.17.Foram determinadas as concentrações de água, sódio, potássio, cálcio, fósforo, magnésio, cobre, ferro, enxôfre e nitrogênio de espécimes de dura máter aparentemente normal retirados de 18 indivíduos recentemente falecidos em conseqüência de traumatismo crânio-encefálico. As concentrações médias, expressas em peso seco, foram as seguintes: água 79,55 g/100 g ± 2,52; sódio 1,63 mequiv/100 g ± 0,27; potássio 3,68 mequiv/100 g ± 0,66; cálcio 119,84 mg/100 g ± 107,40; fósforo 68,2 mg/100 g ± 34,5; magnésio 0,61 mequiv/100 g ± 0,37; cobre 249,8 mg/100 ± 109,4; ferro 0,82 mg/100 g ± 0,28; enxôfre 490,7 mg/100 g ± 22,5; nitrogênio 3,33 g/100 g ± 0,17.

  20. 妊娠中期唐氏筛查在高龄孕妇产前诊断中必要性探讨%Approach the necessary of prenatal screening about down syndrome from of advanced materal age in pregnancy trimester

    Institute of Scientific and Technical Information of China (English)

    宋桂宁; 梁梅英; 张颜秋; 张璘; 徐红; 任梅宏

    2011-01-01

    Objective Approach the meaning of prenatal screening about down syndrome in prenatal diagnosis form pregnant women of advanced maternal age. Methods Amniocentesis were performed in 899 pregantwomen of advanced materal age with the indiations of prenatal diagnosis during 17-24 gestationalweeks and fetal chromom alkarynotypeswere examined in amniotic fluid.Results 6 abnomal chromosomal karyotypes were found in146 pregnantwomen with an increased risk of DS(≥1/270)(chose alpha-fetoprotein(AFP)and free E3 (uE3)and free β-hCG) .Patients with an increased risk of DS(≥1/270).(.Trisomy 21 was 4.11%(6/146 ) .12 abnomal chromosomal karyotypes were found in 753 pregnantwomen without prenatal screening.Trisomy 21 was 0.67%(5/750 ) .Conclusion It is higher effectiness among women of advanced maternal age about prenatal screening than without prenatal screening among women of advanced maternal age in pregnancy trimester.To suggest prenatal screening among women of advanced materal age in pregnancy trimester.%目的 探讨唐氏筛查在高龄孕妇产前诊断中的意义. 方法有产前诊断指征的高龄孕妇899人,孕中期17-24周行羊膜腔穿刺,取羊水检查胎儿染色体.结果 发现染色体异常6例在146例唐氏综合症筛查阳性(即孕妇血清甲胎蛋白(AFP)和游离性雌三醇(uE3)以及游离人绒毛膜促性腺激素(β-hCG)三联指标检测,将三联指标测定值输入唐氏综合征风险计算软件,以1/270为高危切割值,≥1/270确定为唐氏综合征筛查阳性)的高龄孕妇中,发现染色体异常6例唐氏综合征发生率为4.11%(6/146),高龄孕妇中未行唐氏筛查人数750人次,染色体异常人数12人,唐氏综合征发生率0.67%(5/750). 结论对高龄孕妇行孕中期血清血液筛查胎儿唐氏综合征,其筛查效率高于孕中期未行血清血液筛查的高龄孕妇,建议对高龄孕妇行孕中期胎儿唐氏综合征产前筛查.

  1. La categorización adverbonominal. Las estructuras ADV(Nment vôtre / ADV(Nly yours

    Directory of Open Access Journals (Sweden)

    Luisa Mora Millán

    2011-01-01

    Full Text Available The adverb is a prolific category, especially with regard to neologisms. In this paper we analyze some noun-based adverbial neologisms, found in the lexicon of the internet, with the shared characteristic that they cannot be paraphrased by structures of the type in a/a Adj manner or any other structure usually associated with adverbs ending in -ment (-ly. We propose the term adverb-nominal to refer to the twofold mode of signification of these neologisms.

  2. KamLAND-PICO Dark Mater Search Project

    Science.gov (United States)

    Fushimi, K.; Awatani, Y.; Ejiri, H.; Hazama, R.; Ikeda, H.; Imagawa, K.; Inoue, K.; Kozlov, A.; Orito, R.; Shima, T.; Sugawara, R.; Yasuda, K.

    Dark matter search project KamLAND-PICO is proposed. The first phase of the project aims to verifying the annual modulation signal which has been reported by DAMA/LIBRA. The last phase of the project aims to determining the type of interaction between WIMPs and nucleus. The thin and wide area NaI(Tl) detector PICO-LON has been developed to determine the type of WIMPs interaction. The good performance of PICO-LON detector was obtained. The energy threshold was as low as 2 keVee and the the energy resolution was as small as 25% at 60 keVee. The highly pure NaI(Tl) crystal has been developed in collaboration with the Japanese developer. The purity of U and Th chain contaminants have been reduced to the order of a few tens of ppt. It should be remarked that the concentration of 210Pb was reduced to about 60 μBq/kg. The sensitivity to spin-independent WIMPs are discussed by applying 170 modules of NaI(Tl) with the dimension of 5 inch ϕ× 5 inch.

  3. Raviscanina, contrada Canale, Quattroventi, loc. Mater deorum Mesa

    OpenAIRE

    Parma, Aniello

    2015-01-01

    Il culto è ricordato da un’iscrizione rinvenuta nel 1939 nel territorio di Raviscanina, in contrada Canale, nel fondo Longo presso la località Quattroventi (fig. 3) e attualmente conservata nel Museo Nazionale di Napoli. Nella località di rinvenimento vi sono resti di una vasta villa o di un vicus, forse identificabile con l’Ebutiana della Tab. Peut. 5, 3; pertanto l’iscrizione potrebbe essere frutto di spoliazione dalla città di Allifae, ma potrebbe anche documentare un culto vicano. Fig. 3 ...

  4. Alma mater NYC : võimenda, kiirenda, kuhja / Mariliis Lilover

    Index Scriptorium Estoniae

    Lilover, Mariliis

    2014-01-01

    Mariliis Liloveri arhitektuurialastest õpingutest New Yorgis (Graduate School of Architecture, Planning and Preservation at Columbia University) ja tema arvamusest, et koolide ülesandeks on koolitada selline arhitekt, kelle eesmärk peaks olema ületada nii iseennast kui ka tellija unistusi, kavandades midagi, mida klient algul ei osanud soovida, kuid usub lõpuks, et just sellisest tulemusest ta unistaski

  5. The Marriage of Alma Mater to Adam Smith.

    Science.gov (United States)

    Buescher, John B.

    1987-01-01

    Businesses and universities must be encouraged to act from their traditional positions of strength, based on the longest view and the broadest interests. They must examine carefully their potential sources of conflict as well as opportunities for benefit before engaging in alliances that may become complex and difficult to manage. (MSE)

  6. Warm dense mater: another application for pulsed power hydrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Reinovsky, Robert Emil [Los Alamos National Laboratory

    2009-01-01

    Pulsed Power Hydrodynamics (PPH) is an application of low-impedance pulsed power, and high magnetic field technology to the study of advanced hydrodynamic problems, instabilities, turbulence, and material properties. PPH can potentially be applied to the study of the properties of warm dense matter (WDM) as well. Exploration of the properties of warm dense matter such as equation of state, viscosity, conductivity is an emerging area of study focused on the behavior of matter at density near solid density (from 10% of solid density to slightly above solid density) and modest temperatures ({approx}1-10 eV). Conditions characteristic of WDM are difficult to obtain, and even more difficult to diagnose. One approach to producing WDM uses laser or particle beam heating of very small quantities of matter on timescales short compared to the subsequent hydrodynamic expansion timescales (isochoric heating) and a vigorous community of researchers are applying these techniques. Pulsed power hydrodynamic techniques, such as large convergence liner compression of a large volume, modest density, low temperature plasma to densities approaching solid density or through multiple shock compression and heating of normal density material between a massive, high density, energetic liner and a high density central 'anvil' are possible ways to reach relevant conditions. Another avenue to WDM conditions is through the explosion and subsequent expansion of a conductor (wire) against a high pressure (density) gas background (isobaric expansion) techniques. However, both techniques demand substantial energy, proper power conditioning and delivery, and an understanding of the hydrodynamic and instability processes that limit each technique. In this paper we will examine the challenges to pulsed power technology and to pulsed power systems presented by the opportunity to explore this interesting region of parameter space.

  7. Alma mater sõnas, pildis ja helis / Varje Sootak

    Index Scriptorium Estoniae

    Sootak, Varje, 1946-

    2007-01-01

    Tartu Ülikooli 375. aastapäeva puhul esitleti ülikooli kohvikus albumit "Universitas Tartuensis 375" ja samanimelise dokumentaalfilmi DVD-d. Viimase stsenaristideks on Jaak Lõhmus ja Lauri Vahtre, režissöörideks Rene Vilbre ja Märten Vaher

  8. Volume 1B. Modification of mater - MISC 4.

    Energy Technology Data Exchange (ETDEWEB)

    Sawyer, Walter K. [Mathematical & Computer Services, Inc., Danville, VA (United States); Schenewerk, Philip A. [Louisiana State Univ., Baton Rouge, LA (United States); Kimbrell, W. Clay [Louisiana State Univ., Baton Rouge, LA (United States)

    1995-12-31

    MISC4, the modified PC version of the MASTER reservoir simulation model is for use in simulating miscible gas injection processes in steeply dipping reservoirs, is a three-dimensional, three-phase, finite-difference, black oil simulator based on the implicit pressure, explicit saturation (WIPES) algorithm. The simulation code has been modified and includes a dip feature for dealing with steeply dipping reservoirs, and the program has been successfully installed and operated on in-house PCs.

  9. PRAVICE MATER PRI NADOMESTNEM MATERINSTVU V EVROPSKI UNIJI (EU)

    OpenAIRE

    Neuvirt, Gabrijela

    2014-01-01

    Nadomestno materinstvo je eden izmed načinov, kako lahko par, ki ne more spočeti otroka po naravni poti, dobi potomca. Nadomestna mati, »živi inkubator« posodi svojo maternico z namenom donositi in roditi tujega otroka, ki ga nato trajno izroči biološkima staršema. Gre za surogatno obliko starševstva, ki je razširjena po vsem svetu, vendar je hkrati tudi povsod, v odvisnosti od kulture, zgodovine, etike, gospodarskega razvoja in vere drugače pravno urejena. Diplomsko delo se osredotoča n...

  10. 冻干硬脑膜内骨形成蛋白-自固化磷酸钙复合移植修复骨缺损%Repairing bone defects using bone morphogenetic protein and calcium phosphate cement combined with freeze-dried dura mater

    Institute of Scientific and Technical Information of China (English)

    邹国耀; 吴恒烜

    2009-01-01

    背景:骨形成蛋白和自固化磷酸钙各自有着良好的成骨能力,冻干硬脑膜内骨形成蛋白和自固化磷酸钙复合移植存在优化成骨效能的可能性.目的:以冻干硬脑膜为膜材料,观察膜内充填材料骨形成蛋白复合自固化磷酸钙移植修复节段性骨缺损的效果.设计、时间及地点:随机分组设计,动物体内组织病理学对照观察,于2006-07/2007-07在广西医科大学动物实验室完成.对象:健康成年新西兰大白兔28只,雌雄不限,体质量1.5~2.5 kg.方法:实验兔28只,其中4只用于取硬脑膜.其余24只随机分成A,B两大组,每组12只.A组制造双侧兔桡骨中段10 mm的骨缺损.一侧骨缺损用骨形成蛋白、自固化磷酸钙、冻干硬脑膜复合移植修复,为骨形成蛋白组, 另一侧不予处理作为空白对照组.B组制造单侧兔桡骨中段10 mm的骨缺损,用骨髓、自固化磷酸钙、冻干硬脑膜复合移植修复称骨髓组.主要观察指标:于术后第1,2,4,6,8,10,12周分别行双侧桡骨X射线检查.观察骨缺损处的新骨形成及骨修复情况.并于术后第2,4,8,12周切取标本行组织学检查及成骨面积分析.结果:在术后第4,8,12周,骨形成蛋白组的成骨面积大于骨髓组(P<0.05),而在实验早期(术后2周)两组间差异无显著性意义(P>0.05);在实验的各个时期,骨形成蛋白组和骨髓组的成骨面积均明显大于空白组(P<0.01).X射线结果显示,骨形成蛋白组在10~12周出现明显骨痂塑形现象;组织学病理切片结果显示,骨形成蛋白组在12周时桡骨可见成熟骨髓,骨缺损处为成熟的板层骨连接.结论:骨形成蛋白复合自固化磷酸钙与冻干硬脑膜移植具有良好的成骨作用.%BACKGROUND: Both bone morphogenetic protein (BMP) and calcium phosphate cement (CPC) have excellent osteogenic capability, so, it is possible to optimize osteogenic efficiency by combing BMP, CPC and freeze-dried dura mater (FDDM

  11. Light emitting transistors: A new route for display pixels (Presentation Recording)

    Science.gov (United States)

    Namdas, Ebinazar B.

    2015-10-01

    Organic light emitting transistors (LEFETs) are an emerging class of light emitting devices that have been successfully demonstrated in single-layer [1] and mutli-layer device structures [2]. LEFETs can simultaneously execute light-emission and standard logic functions (ON/OFF) of a transistor in a single device architecture [1]. This dual functionality of LEFETs has a potential to offer a new route to simplify fabrication of display pixels. However, the key problem of existing LEFETs thus far has been their low external quantum efficiency (EQE) at high brightness, poor ON/OFF ratio, and mobility. More recently, hybrid light emitting transistors [3-4], consisting of solution processed n-type metal oxide (inorganic) as the charge transport layer and light emitting conjugated polymer (organic), have been used to achieve higher mobility, ON/OFF ratio and brightness. In this talk, I will discuss the various factors that currently influence device performance in LEFETs, and will provide insights into our recent progress in developing high-performance hybrid LEFETs. References: (1). E. B. Namdas, J. S. Swensen, P. Ledochowitsch, J. D. Yuen, D. Moses, A. J. Heeger, Adv. Mater.,20, 1321 (2008). (2). M. Ullah, K. Tandy, S. D. Yambem, M. Aljada, P. L. Burn, P. Meredith, E. B. Namdas. Adv. Mater. 25, 6213-6218 (2013). (3). B. Walker, M. Ullah, G. J. Chae, P. L Burn, S. Cho, J. Y. Kim, E. B. Namdas, J. H. Seo. Appl Phys Lett, 105, 183302 (2014). (4). K. Muhieddine, M. Ullah, B. N. Pal, P. Burn, E. B. Namdas, Adv. Mater. 26, 6410 (2014).

  12. Corrigendum to “Geometric Arveson–Douglas conjecture” [Adv. Math. 274 (2015) 606–630

    Czech Academy of Sciences Publication Activity Database

    Engliš, Miroslav; Eschmeier, J.

    2015-01-01

    Roč. 278, June (2015), s. 254. ISSN 0001-8708 Institutional support: RVO:67985840 Keywords : Arveson-Douglas conjecture * generalized Toeplitz operator Subject RIV: BA - General Mathematics Impact factor: 1.294, year: 2014 http://www.sciencedirect.com/science/article/pii/S000187081500119X

  13. STABILITY OF ORGANIC MATER OF HAPLIC CHERNOZEM AND HAPLIC LUVISOL OF DIFFERENT ECOSYSTEMS

    Directory of Open Access Journals (Sweden)

    ERIKA TOBIAŠOVÁ

    2013-12-01

    Full Text Available In this study, the changes in soil organic matter (SOM and the possibilities of their monitoring in a shorter period of time by means of carbon parameters were followed. The experiment includes four ecosystems (forest, meadow, urban, and agro-ecosystem on Haplic Chernozem (Močenok, Horná Kráľová, Trnava and Haplic Luvisol (Ludanice, Veľké Zálužie, Lovce of different localities. The objectives of this study were assessment of the differences in the stability of soil organic matter in different ecosystems and in soil types using labile forms of carbon and nitrogen, and also with dependence on particle size distribution. The highest contents of total organic carbon (TOC and labile carbon (CL were in a forest ecosystem, but in case of other ecosystems, the differences were determined only in the contents of CL. After forest ecosystem, the highest content of CL was in agro-ecosystem > meadow ecosystem > urban ecosystem. Based on parameter of lability of carbon (LC, the most labile carbon can be evaluated also in the forest ecosystem (0.209 > agro-ecosystem (0.178 > meadow ecosystem (0.119 and urban ecosystem (0.116. In the case of nitrogen, the differences were observed between the soils. Higher contents of NT and NL were recorded in Haplic Chernozen than in Haplic Luvisol. Contents of TOC (P < 0.05; r = -0.480, CNL (P < 0.05; r = -0.480, and NL (P < 0.01; r = -0.545 were in a negative correlation with the content of sand fraction. The values of studied parameters in meadow and urban ecosystems were relatively balanced, because in both cases, the vegetation cover were grass, pointing to a significant influence of vegetation on the parameters of SOM.

  14. Cross-modal associations between materic painting and classical Spanish music.

    Science.gov (United States)

    Albertazzi, Liliana; Canal, Luisa; Micciolo, Rocco

    2015-01-01

    The study analyses the existence of cross-modal associations in the general population between a series of paintings and a series of clips of classical (guitar) music. Because of the complexity of the stimuli, the study differs from previous analyses conducted on the association between visual and auditory stimuli, which predominantly analyzed single tones and colors by means of psychophysical methods and forced choice responses. More recently, the relation between music and shape has been analyzed in terms of music visualization, or relatively to the role played by emotion in the association, and free response paradigms have also been accepted. In our study, in order to investigate what attributes may be responsible for the phenomenon of the association between visual and auditory stimuli, the clip/painting association was tested in two experiments: the first used the semantic differential on a unidimensional rating scale of adjectives; the second employed a specific methodology based on subjective perceptual judgments in first person account. Because of the complexity of the stimuli, it was decided to have the maximum possible uniformity of style, composition and musical color. The results show that multisensory features expressed by adjectives such as "quick," "agitated," and "strong," and their antonyms "slow," "calm," and "weak" characterized both the visual and auditory stimuli, and that they may have had a role in the associations. The results also suggest that the main perceptual features responsible for the clip/painting associations were hue, lightness, timbre, and musical tempo. Contrary to what was expected, the musical mode usually related to feelings of happiness (major mode), or to feelings of sadness (minor mode), and spatial orientation (vertical and horizontal) did not play a significant role in the association. The consistency of the associations was shown when evaluated on the whole sample, and after considering the different backgrounds and expertise of the subjects. No substantial difference was found between expert and non-expert subjects. The methods used in the experiment (semantic differential and subjective judgements in first person account) corroborated the interpretation of the results as associations due to patterns of qualitative similarity present in stimuli of different sensory modalities and experienced as such by the subjects. The main result of the study consists in showing the existence of cross-modal associations between highly complex stimuli; furthermore, the second experiment employed a specific methodology based on subjective perceptual judgments. PMID:25954217

  15. Cross-modal associations between materic painting and classical Spanish music

    Science.gov (United States)

    Albertazzi, Liliana; Canal, Luisa; Micciolo, Rocco

    2015-01-01

    The study analyses the existence of cross-modal associations in the general population between a series of paintings and a series of clips of classical (guitar) music. Because of the complexity of the stimuli, the study differs from previous analyses conducted on the association between visual and auditory stimuli, which predominantly analyzed single tones and colors by means of psychophysical methods and forced choice responses. More recently, the relation between music and shape has been analyzed in terms of music visualization, or relatively to the role played by emotion in the association, and free response paradigms have also been accepted. In our study, in order to investigate what attributes may be responsible for the phenomenon of the association between visual and auditory stimuli, the clip/painting association was tested in two experiments: the first used the semantic differential on a unidimensional rating scale of adjectives; the second employed a specific methodology based on subjective perceptual judgments in first person account. Because of the complexity of the stimuli, it was decided to have the maximum possible uniformity of style, composition and musical color. The results show that multisensory features expressed by adjectives such as “quick,” “agitated,” and “strong,” and their antonyms “slow,” “calm,” and “weak” characterized both the visual and auditory stimuli, and that they may have had a role in the associations. The results also suggest that the main perceptual features responsible for the clip/painting associations were hue, lightness, timbre, and musical tempo. Contrary to what was expected, the musical mode usually related to feelings of happiness (major mode), or to feelings of sadness (minor mode), and spatial orientation (vertical and horizontal) did not play a significant role in the association. The consistency of the associations was shown when evaluated on the whole sample, and after considering the different backgrounds and expertise of the subjects. No substantial difference was found between expert and non-expert subjects. The methods used in the experiment (semantic differential and subjective judgements in first person account) corroborated the interpretation of the results as associations due to patterns of qualitative similarity present in stimuli of different sensory modalities and experienced as such by the subjects. The main result of the study consists in showing the existence of cross-modal associations between highly complex stimuli; furthermore, the second experiment employed a specific methodology based on subjective perceptual judgments. PMID:25954217

  16. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain

    International Nuclear Information System (INIS)

    Utilizing 125I-BSA administered intravenously, a simple, reliable, and sensitive method was established for the detection of plasma protein extravasation in the dura of rats and guinea pigs following chemical, electrical, or immunological stimulation. Extravasated 125I-BSA or Evans blue was noted in the dura and conjunctiva but not in the temporalis muscle of saline-perfused rats following intravenous capsaicin, 1 mumol/kg. Capsaicin-induced extravasation was mediated by unmyelinated and small myelinated fibers since leakage did not develop in adult animals in whom these fibers were destroyed by capsaicin pretreatment (50 mg/kg) as neonates. An ipsilateral increase in Evans blue and 125I-BSA was found in the dura, eyelids, lips and gingival mucosa, and snout following electrical stimulation of the rat trigeminal ganglion. This increase was also C-fiber dependent. Among those peptides contained in perivascular afferent fibers and administered intravenously, substance P (SP) and neurokinin A (NKA), but not calcitonin gene-related peptide, caused a dose-dependent extravasation in the dura and conjunctiva of rats. Neonatal capsaicin pretreatment did not attenuate SP- nor NKA-induced effects in the dura and actually increased extravasation in the conjunctiva. Intravenous administration of 5-HT or bradykinin to normal adult rats or adult rats pretreated as neonates with capsaicin increased levels of 125I-BSA in both the dura and the conjunctiva. Histamine and prostaglandin E2, on the other hand, caused protein leakage in the conjunctiva but not in the dura of rats; however, histamine did induce extravasation in the dura of guinea pigs

  17. Talis mater, talis filia: las malas madres en los siglos XVI y XVII

    OpenAIRE

    Amaia Nausia Pimoulier

    2013-01-01

    Este artículo presenta un tipo de violencia familiar protagonizado por madres e hijas navarras de los siglos XVI y XVII. Las acu- saciones por lenocinio o alcahuetería contra las madres que emplearon a sus propias hijas en sus tratos de mediadoras sirven para ilustrar una forma de violencia que supone, entre otras cosas, una ruptura del amor materno. La precaria situación de la madre y las dificultades tras el fallecimiento del esposo —la gran parte de los casos están protagonizados por m...

  18. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain

    Energy Technology Data Exchange (ETDEWEB)

    Markowitz, S.; Saito, K.; Moskowitz, M.A.

    1987-12-01

    Utilizing /sup 125/I-BSA administered intravenously, a simple, reliable, and sensitive method was established for the detection of plasma protein extravasation in the dura of rats and guinea pigs following chemical, electrical, or immunological stimulation. Extravasated /sup 125/I-BSA or Evans blue was noted in the dura and conjunctiva but not in the temporalis muscle of saline-perfused rats following intravenous capsaicin, 1 mumol/kg. Capsaicin-induced extravasation was mediated by unmyelinated and small myelinated fibers since leakage did not develop in adult animals in whom these fibers were destroyed by capsaicin pretreatment (50 mg/kg) as neonates. An ipsilateral increase in Evans blue and /sup 125/I-BSA was found in the dura, eyelids, lips and gingival mucosa, and snout following electrical stimulation of the rat trigeminal ganglion. This increase was also C-fiber dependent. Among those peptides contained in perivascular afferent fibers and administered intravenously, substance P (SP) and neurokinin A (NKA), but not calcitonin gene-related peptide, caused a dose-dependent extravasation in the dura and conjunctiva of rats. Neonatal capsaicin pretreatment did not attenuate SP- nor NKA-induced effects in the dura and actually increased extravasation in the conjunctiva. Intravenous administration of 5-HT or bradykinin to normal adult rats or adult rats pretreated as neonates with capsaicin increased levels of /sup 125/I-BSA in both the dura and the conjunctiva. Histamine and prostaglandin E2, on the other hand, caused protein leakage in the conjunctiva but not in the dura of rats; however, histamine did induce extravasation in the dura of guinea pigs.

  19. Cross-Modal Associations between Materic Painting and Classical Spanish Music

    Directory of Open Access Journals (Sweden)

    Liliana eAlbertazzi

    2015-04-01

    Full Text Available The study analyses the existence of cross-modal associations in the general population between a series of paintings and a series of clips of classical (guitar music. Because of the complexity of the stimuli, the study differs from previous analyses conducted on the association between visual and acoustic stimuli, which predominantly analysed single tones and colours by means of psychophysical methods and forced choice responses. More recently, the relation between music and shape has been analyzed in terms of music visualization, or relatively to the role played by emotion in the association, and free response paradigms have also been accepted. In our study, in order to investigate what attributes may be responsible for the phenomenon of the association between visual and acoustic stimuli, the clip/painting association was tested in two experiments: the first used the semantic differential on a unidimensional rating scale of adjectives; the second employed a specific methodology based on subjective perceptual judgments in first person account. Because of the complexity of the stimuli, it was decided to have the maximum possible uniformity of style, composition and musical colour. The results show that multisensory features expressed by adjectives such as ‘quick’, ‘agitated’, and ‘strong’, and their antonyms ‘slow’, ‘calm’, and ‘weak’ characterized both the visual and acoustic stimuli, and that they may have had a role in the associations. The results also suggest that the main perceptual features responsible for the clip/painting associations were hue, lightness, timbre, and musical tempo. Contrary to what was expected, the musical mode usually related to feelings of happiness or to feelings of sadness and spatial orientation did not play a significant role in the association. The main result of the study consists in showing the existence of cross-modal associations between high complex stimuli.

  20. Non-singular modified gravity: the unification of the inflation, dark energy and dark mater

    CERN Document Server

    Nojiri, Shin'ichi

    2009-01-01

    Using the fluid representation, we formulate the conditions for the appearance of all four types finite-time future singularity in modified gravity in accelerating FRW universe. It stressed that number of standard uintessence/phantom DE theories (including scalar, fluid, DBI ones, etc) brings the accelerating cosmology to future singularity precisely in the same way as singular modified gravity DE. The viable non-singular modified gravity unifying the early-time inflation with late-time acceleration is considered. It is shown that adding such non-singular theory to another realistic singular modified gravity which has the accelerating solution with future singularity may cure the singularity of resulting combined model. This universal scenario may be naturally applied to standard singular DE models as well as to inflationary theories with initial singularity. This suggests the additional fundamental reasoning for modification of General Relativity.

  1. Mater Nostra: The Anti-blasphemy Message of the Feminist Punk-Prayer

    OpenAIRE

    Elena Ivanovna Volkova

    2014-01-01

    In this essay I develop a blasphemy counter-discourse arguing that it was ecclesial and state authorities who committed blasphemies, which were condemned by Pussy Riot’s punk-prayer. Thus, the performance in this respect may be interpreted as an anti-blasphemy protest. The blasphemy list includes the collaboration of the church with the authoritarian state, known as heresy of Sergianism; Caesar and Temple idolatry, blasphemy against the Holy Spirit, Virgin Mary and Folly for Christ’s sake. Th...

  2. Talis mater, talis filia: las malas madres en los siglos XVI y XVII

    Directory of Open Access Journals (Sweden)

    Amaia Nausia Pimoulier

    2013-12-01

    Full Text Available Este artículo presenta un tipo de violencia familiar protagonizado por madres e hijas navarras de los siglos XVI y XVII. Las acu-saciones por lenocinio o alcahuetería contra las madres que emplearon a sus propias hijas en sus tratos de mediadoras sirven para ilustrar una forma de violencia que supone, entre otras cosas, una ruptura del amor materno. La preca-ria situación de la madre y las dificultades tras el fallecimiento del esposo —la gran parte de los casos están protagonizados por madres viu-das— fue el contexto general en el que se desarrollaron los malos tratos. La historia de estas mujeres representa un mal ejercicio de la autoridad materna y una forma de violencia hacia las hijas; una violencia no siempre física, pero sí emocional y psicológica.

  3. Comparison of Dry Mater Content of Pig Faeces in Two Belt Separation Systems

    OpenAIRE

    Alonso Peralta, Francisco; Vázquez Minguela, Jesús; Sanchez Espinosa, Elvira; Ovejero Rubio, Ismael; Mateos San Juan, Aranzazu; Garcimartin Molina, Miguel Angel

    2008-01-01

    The average production of slurry per animal per day lies between 3 and 7 kg during a period of swine fattening. Spain is the world’s fourth largest producer of pork. The size of farms and their density are growing faster and faster. Therefore, slurry management is becoming an environmental problem due to air and soil pollution. Separating faeces and urine improves waste management and reduces the levels of environmental pollution. Since 1999 different systems aimed at this separation have bee...

  4. Skipping Out on Alma Mater: Some Problems Involving the Collection of Federal Student Loans.

    Science.gov (United States)

    Leonard, Kevin J.

    1980-01-01

    Present law respecting collection of federal student loans, regulatory and other sanctions against default, and strategies against bankruptcy are outlined and analyzed. (Journal availability: Columbia Journal of Law and Social Problems, Box 7, Columbia University School of Law, 435 W. 116th St., New York, NY 10027, $5.00.) (MSE)

  5. Factors Associated with Non-Traditional and Traditional Undergraduate Alumni Giving to Alma Maters

    Science.gov (United States)

    Johnson, Elizabeth Ann Miller

    2013-01-01

    Both public and private institutions of higher education face revenue shortfalls. In order to close budget gaps, colleges and universities must identify new revenue sources. Historically alumni are large providers of voluntary support to higher education institutions, but the numbers of alumni contributing financially is decreasing. The purpose of…

  6. A Mathematical Model for the Removal of Organic Mater in Stabilization Ponds

    Directory of Open Access Journals (Sweden)

    Medri Waldir

    2002-01-01

    Full Text Available This work presents an application to systemize the construction of ponds systems for treatment of domestic sewage. It consisted of two anaerobic ponds operated in parallel during May/97 to April/99. These were connected in series with a chicaned facultative pond. The treatment system was controlled with samples collected from the crude sewage (compound sample, in the affluents and effluents of the ponds and along the flux of the anaerobic and facultative ponds. The following parameters were analyzed: pH, Biochemical Oxygen Demand, Chemical Oxygen Demand, Total Solids, Sedimentable Solids, Total Coliforms, Oxygen Consumed in Acid Medium (OCAM and temperature.

  7. A Mathematical Model for the Removal of Organic Mater in Stabilization Ponds

    OpenAIRE

    Medri Waldir; Medri Vandir

    2002-01-01

    This work presents an application to systemize the construction of ponds systems for treatment of domestic sewage. It consisted of two anaerobic ponds operated in parallel during May/97 to April/99. These were connected in series with a chicaned facultative pond. The treatment system was controlled with samples collected from the crude sewage (compound sample), in the affluents and effluents of the ponds and along the flux of the anaerobic and facultative ponds. The following parameters were ...

  8. Diatoms : an ecoregional indicator of nutrients, organic mater and micropollutants pollution

    OpenAIRE

    Rimet, Frédéric,

    2012-01-01

    Diatoms are ubiquitous microalgae of an extreme diversity. This made them good indicators of aquatic ecosystems quality and they are used since 50 years for this purpose. Since year 2000, the European Water Framework Directive requires their use to assess the ecological quality of watercourses. A typological framework has to be used in order to compare comparable rivers between each other, that is, rivers of the same bioclimatic regions, flowing on the same geological substrate at similar alt...

  9. Graphene sheets stacked polyacrylate latex composites for ultra-efficient electromagnetic shielding

    Science.gov (United States)

    Li, Yong; Zhang, Song; Ni, Yuwei

    2016-07-01

    Graphene sheets (GS) are at the forefront of electromagnetic interference (EMI) shielding/attenuation materials science research because of their excellent electrical properties (Wen B et al 2014 Adv. Mater. 26 3484, Zhang Y et al 2015 Adv. Mater. 27 2049). GS/polyacrylate (PA) composites were prepared using a solvent-free latex technology, which favored the build-up of a segregated GS architecture stacked in the polymer matrix. GS were obtained from graphite flakes (GF) via a mechanical delamination approach in water. The microstructure, electrical, dielectric and electromagnetic shielding properties of the GS/PA composites were correlated in this manuscript. A remarkably low percolation threshold of ∼0.11 mass per cent for room-temperature electrical conductivity was obtained in the GS/PA composites owing to the stacked architecture of GS with high aspect ratios. This unique nanostructured GS architecture not only enhanced the electrical conductivity of composites, but also dramatically increased complex permittivity by inducing strong Maxwell–Wagner–Sillars (MWS) polarization at the highly conductive GS/non-conductive PA interfaces. The EMI shielding effectiveness (SE) of these composites was enhanced with increasing GS content, and the composite with 6 wt% GS loading exhibited a high EMI SE of ∼66 dB over a frequency of 8.2–12.4 GHz, resulting from the pronounced conduction loss, dielectric relaxation, and multi-scattering.

  10. Adv. Simulation for Additive Manufacturing: 11/2014 Wkshp. Report for U.S. DOE/EERE/AMO

    Energy Technology Data Exchange (ETDEWEB)

    Turner, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Babu, Sudarsanam Suresh [Univ. of Tennessee, Knoxville, TN (United States); Blue, Craig A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-07-01

    The overarching question for the workshop was as following: How do we best utilize advanced modeling and high-performance computing (HPC) to address key challenges and opportunities in order to realize the full potential of additive manufacturing; and what are the key challenges of additive manufacturing to which modeling and simulation can contribute solutions, and what will it take to meet these challenges?

  11. EDITORIAL: Nanomemory: information and ingenuity Nanomemory: information and ingenuity

    Science.gov (United States)

    Demming, Anna

    2013-04-01

    Adv. Funct. Mater 20 330-7 [11] Bose S, Kim N H, Kuila T, Lau K-T and Lee J H 2011 Electrochemical performance of a graphene-polypyrrole nanocomposite as a supercapacitor electrode Nanotechnology 22 295202 [12] Loomis J, King B, Burkhead T, Xu P, Bessler N, Terentjev E and Panchapakesan B 2012 Graphene-nanoplatelet-based photomechanical actuators Nanotechnology 23 045501 [13] Finn C A 2001 Artifacts: An Archaeologist's Year in Silicon Valley (Cambridge, MA: MIT Press)

  12. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    International Nuclear Information System (INIS)

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d’Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet the extra-European connections with Brazil, China and India will be guaranteed: in China, with the Shanghai Observatory of the Chinese Academy of Science, studying the formation and evolution of large-scale structure and galaxies; in India, with the Indian Centre for Space Physics (ICSP), renowned for its research on compact objects as well as on solar physics and astrochemistry; in Brazil with ICRANet Brazil where a successful program of research and teaching in relativistic astrophysics has been established in recent years

  13. Rukopis Mater verborum jako problém paleografický, kodikologický i uměleckohistorický

    Czech Academy of Sciences Publication Activity Database

    Brodský, Pavel

    2013-01-01

    Roč. 2012, č. 1 (2013), s. 139-145. ISSN 2084-1213. [Ars scribendi. O sztuce pisania w średniowiecznych Czechach i Polsce. Gniezno, 15.09.2008-17.09.2008] Institutional support: RVO:67985921 Keywords : codicology * iconography * Middle Ages Subject RIV: AB - History

  14. What Is Gravity and How Is Embedded in Mater Particles giving them mass (not the Higgs field)?

    OpenAIRE

    Mehedinteanu, Stefan

    2016-01-01

    It will be shown how the Micro-black-holes particles produced at the horizon entry into a number of 62 61 10   N by quantum fluctuation as virtual micro-black holes pairs like e+ e-creation, stay at the base of: the origin and evolution of Universe, the Black Holes (BH) nuclei of galaxies, of the free photons creation of near mass-less as by radiation decay that condensate later at Confinement in to the structure of gauge bosons (gluons). Also, these ex-Micro-black-holes (BHs 

  15. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    Energy Technology Data Exchange (ETDEWEB)

    Chardonnet, Pascal [Coordinator IRAP PhD EMJD, Université de Nice 28, avenue Valrose 06103 Nice (France); LAPTh, Université de Savoie, CNRS, B.P. 110, Annecy-le-Vieux F-74941 (France); ICRANet, Piazza della Repubblica 10, 65122 Pescara (Italy); Department for Theoretical Nuclear Physics, National Research Nuclear University Moscow Engineering Physics Institute, MEPhI, Moscow (Russian Federation)

    2015-12-17

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d’Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet the extra-European connections with Brazil, China and India will be guaranteed: in China, with the Shanghai Observatory of the Chinese Academy of Science, studying the formation and evolution of large-scale structure and galaxies; in India, with the Indian Centre for Space Physics (ICSP), renowned for its research on compact objects as well as on solar physics and astrochemistry; in Brazil with ICRANet Brazil where a successful program of research and teaching in relativistic astrophysics has been established in recent years.

  16. The Radiologist and the Magnetic Resonance Imaging Role in a Mater nal-Fe tal Multidisciplinary Unit

    International Nuclear Information System (INIS)

    The purpose of this review is to show the status of the Fetal Magnetic Resonance images in our institution. The fetal MR Imaging has become an important diagnostic tool in the world in the day to day clinical practice, when there is suspicion of any fetal pathology during pregnancy. The acquisition of new technology and the consolidation of the interdisciplinary groups, allow us to strengthen our knowledge in fetal MRI and improve every day in the acquisition of the images. The group of different disciplines including obstetrics, pediatric surgery, pediatric cardiology, pediatric neurology, perinatology, psychology, pathology, genetics, radiology and also MR technology with the same goal toward the early diagnosis of any fetal pathology contribute with the progress and confirmation of a difficult diagnosis in particular when there is any sonographic doubt of occult anomaly of the fetal brain or spine. We show some of our cases.

  17. Efeito da quercetina sobre o extravasamento plasmático no sistema nervoso dura-mater de ratos

    Directory of Open Access Journals (Sweden)

    Luiz Arthur Rangel Cyrino

    2002-01-01

    Full Text Available Estudos recentes têm demonstrado que os bioflavonóides afetam vários sistemas enzimáticos nos mamíferos. A dura-máter é um tecido que recebe inervação peptidérgica. No cérebro, a inflamação neurogênica envolve a liberação da substância P (SP por terminais nervosos sensoriais e é modulada pela endopeptidase neutra (NEP e pela enzima conversora da angiotensina (ECA. Neste estudo, avaliamos o efeito da quercetina, que representa mais de 50% dos bioflavonóides, sobre o extravasamento plasmático induzido pela SP em tecidos selecionados no sistema nervoso central de ratos e dura-máter. Também examinamos o efeito da inibição seletiva das enzimas metabolizadoras da SP (NEP e ECA. A administração de SP (10 nmol/kg e 30 nmol/kg, i.v. aumentou o extravasamento plasmático de maneira dose dependente na duramáter, não apresentando nenhum efeito nos outros tecidos; este efeito foi potencializado por inibidores seletivos da NEP e da ECA. A quercetina (30 mg/kg v.o. aumentou o extravasamento plasmático em relação ao controle em todos os tecidos. O prétratamento com quercetina potenciou significativamente o extravasamento plasmático induzido pela SP (10 nmol/kg na dura-máter. Resultados obtidos com o pré-tratamento com antagonistas específicos para receptores da substância P e bradicinina (NK-1 e B2 sugerem que o aumento do extravasamento plasmático induzido pela quercetina e a potenciação da resposta à SP foram devidos ao acúmulo deste neuropeptídeo na dura-máter.

  18. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    Science.gov (United States)

    Chardonnet, Pascal

    2015-12-01

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d'Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet the extra-European connections with Brazil, China and India will be guaranteed: in China, with the Shanghai Observatory of the Chinese Academy of Science, studying the formation and evolution of large-scale structure and galaxies; in India, with the Indian Centre for Space Physics (ICSP), renowned for its research on compact objects as well as on solar physics and astrochemistry; in Brazil with ICRANet Brazil where a successful program of research and teaching in relativistic astrophysics has been established in recent years.

  19. Međunarodni ugovori o zamjenskom majčinstvu - nestaje li paradigma mater semper certa est?

    OpenAIRE

    Župan, Mirela; Puljko, Vjekoslav; Sukačić, Marko

    2013-01-01

    Pravo je korektiv i okvir društvenim pojavama svoga vremena. Stoga pravno promišljanje ne smije ostati indiferentno prema društvenim pojavama koje prate njegovu suvremenost: danas je poglavito tomu tako kada govorimo o prakticiranju medicinskih postupaka poput zamjenskog majčinstva. Naša su promišljanja usmjerena k pravnom okviru u kojemu se u pravilu prakticira zamjensko majčinstvo: međunarodno obilježeni ugovorni odnos te, posljedično, problematika priznanja stranih isprava i statusa stečen...

  20. Quantum modelling of hydrogen chemisorption on graphene and graphite

    International Nuclear Information System (INIS)

    The chemisorption of hydrogen on graphene or graphite is studied within a quantum formalism involving a subsystem coupled to a phonon bath. The subsystem includes the hydrogen atom approaching the surface perpendicularly right on top of a carbon atom which puckers out of the surface. The bath includes the acoustic and optical phonon modes vibrating perpendicularly to the surface. Couplings between subsystem and bath are obtained with a periodic density functional theory calculation. Trapping probabilities are obtained as a function of the hydrogen atom kinetic energy. These results are discussed in the light of the experimental hydrogenation studies performed on graphite by Zecho et al. [J. Chem. Phys. 117, 8486 (2002)] and on graphene by Haberer et al. [Adv. Mater. 23, 4497 (2011)

  1. Soft particle analysis of electrokinetics of biological cells and their model systems

    Energy Technology Data Exchange (ETDEWEB)

    Makino, Kimiko; Ohshima, Hiroyuki, E-mail: makino@rs.noda.tus.ac.jp, E-mail: ohshima@rs.noda.tus.ac.jp [Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510 (Japan)

    2011-03-15

    In this article, we review the applications of a novel theory (Ohshima 2009 Sci. Technol. Adv. Mater. 10 063001) to the analysis of electrokinetic data for various soft particles, that is, particles covered with an ion-permeable surface layer of polyelectrolytes. Soft particles discussed in this review include various biological cells and hydrogel-coated particles as a model of biological cells. Cellular transformations increase the concentration of sialic acid of glycoproteins and are associated with blocked biosynthesis of glycolipids and aberrant expression of the developmentally programmed biosynthetic pathway. The change in shape or biological function of cells may affect their surface properties and can be detected by electrokinetic measurements. The experimental results were analyzed with Ohshima's electrokinetic formula for soft particles and soft surfaces. As a model system, hydrogel surfaces that mimic biological surfaces were also prepared and their surface properties were studied. (topical review)

  2. Dominance of interface chemistry over the bulk properties in determining the electronic structure of epitaxial metal/perovskite oxide heterojunctions

    Energy Technology Data Exchange (ETDEWEB)

    Chambers, Scott A.; Du, Yingge; Gu, Meng; Droubay, Timothy C.; Hepplestone, Steven; Sushko, Petr

    2015-06-09

    We show that despite very similar crystallographic properties and work function values in the bulk, epitaxial Fe and Cr metallizations on Nb:SrTiO3(001) generate completely different heterojunction electronic properties. Cr is Ohmic whereas Fe forms a Schottky barrier with a barrier height of 0.50 eV. This contrast arises because of differences in interface chemistry. In contrast to Cr [Chambers, S. A. et al., Adv. Mater. 2013, 25, 4001.], Fe exhibits a +2 oxidation state and occupies Ti sites in the perovskite lattice, resulting in negligible charge transfer to Ti, upward band bending, and Schottky barrier formation. The differences between Cr and Fe are understood by performing first-principles calculations of the energetics of defect formation which corroborate the observed interface chemistry and structure.

  3. Approach to tune near- and far-field properties of hybrid dimer nanoantennas via laser melting at the nanoscale

    CERN Document Server

    Sun, Yali; Zuev, Dmitry; Huang, Lirong; Krasnok, Alexander; Belov, Pavel

    2016-01-01

    Asymmetric metal-dielectric nanostructures are demonstrated superior optical properties arise from the combination of strong enhancement of their near fields and controllable scattering characteristics which originate from plasmonic and high-index dielectric components. Here, being inspired by the recent experimental work [Dmitry~Zuev, \\textit{et al.}, Adv. Mater. \\textbf{28}, 3087 (2016)] on a new technique for fabrication of asymmetric hybrid nanoparticles via femtosecond laser melting at the nanoscale, we suggest and study numerically a novel type of hybrid dimer nanoantennas. The nanoantennas consist of asymmetric metal-dielectric (Au/Si) nanoparticles and can allow tuning of the near- and far-field properties via laser melting of the metal part. We demonstrate a modification of scattering properties, near electric field distribution, normalized local density of states, and power patters of radiation of the nanoantennas upon laser reshaping. The parameters used to investigate these effects correspond to e...

  4. Conjugated Polymers for Energy Production

    DEFF Research Database (Denmark)

    Livi, Francesco

    This dissertation is aimed at developing materials for flexible, large area, ITO-free polymer solar cells (PSCs) fully printed under ambient conditions. A large screening of conjugated polymers, both novel and well-known materials, has been carried out in order to find suitable candidates...... for scalable PSCs fully printed under ambient conditions [Adv. Energy Mater. 2015, 5, 1402186]. PPDTBT resulted to be the conjugated polymer with the best photovoltaic performance within the 104 synthesized macromolecules. Therefore, further studies have been done on such material. The impact of side chain...... arylation (DAr) and direct arylation polymerization (DArP) have been applied to the preparation of PPDTBT, making this polymer readily available in only 4 synthetic steps and thus easily transferable to a large scale-production setup. DArP avoids organometallic species and therefore is an appealing...

  5. Particle processing technology

    Science.gov (United States)

    Yoshio, Sakka

    2014-02-01

    . Mater. 12 013001 [3] Sakka Y and Uchikoshi T 2010 KONA Powder Particle J. 28 74 (kona.or.jp/search/28_074.pdf) [4] Naguib M, Mashtalir O, Carle J, Presser V, Lu J, Hultman L, Gogotsi Y and Barsoum M W 2012 ACS Nano 6 1322 [5] Sakka Y and Suzuki T S 2005 J. Ceram. Soc. Japan 113 26 [6] Grasso S, Sakka Y and Maizza G 2009 Sci. Technol. Adv. Mater. 10 053001 [7] Nakao H, Tokonami S, Hamada T, Shiigi H, Nagaoka T, Iwate F and Takeda Y 2012 Nanoscale 4 6814 [8] Miyazawa K and Hotta K 2010 J. Cryst. Growth 312 2764 [9] Suehiro T, Xie R and Hirosaki N 2013 Indust. Eng. Chem. Res. 52 7453 [10] Zhu Q, Li J-G, Li X, Sun X and Sakka Y 2011 Sci. Technol. Adv. Mater. 12 055001 [11] Li J, Li J-G, Zhang Z, Wu X, Liu S, Li X, Sun X and Sakka Y 2012 Sci. Technol. Adv. Mater. 13 035007 [12] Kawamura F, Yusa H and Taniguchi T 2012 Appl. Phys. Lett. 100 251910 [13] Watanabe K and Taniguchi T 2011 Int. J. Appl. Ceram. Technol. 8 977 [14] Deng Z-Y, Ferreira J M F and Sakka Y 2008 J. Am. Ceram. Soc. 91 3825 [15] Uda M, Okuyama H, Suzuki T S and Sakka Y 2012 Sci. Technol. Adv. Mater. 13 025009 [16] Takeya H, Kato R, Wakahara T, Miyazawa K, Yamaguchi T, Ozaki T, Okazaki H and Takano Y 2013 Mater. Res. Bull. 48 343 [17] Wakahara T, D'Angelo P, Miyazawa K, Nemoto Y, Ito O, Tanigaki N, Bradley D D C and Anthopoulos T D 2012 J. Am. Chem. Soc. 134 7204 [18] Wiecinska P, Sakka Y, Suzuki T S, Uchikoshi T, Mizerski T and Szafran M 2013 J. Ceram. Soc. Japan 121 89 [19] Kawakita M, Uchikoshi T, Kawakita J and Sakka Y 2009 J. Am. Ceram. Soc. 92 984 [20] Hu C, Sakka Y, Grasso S, Nishimura T, Guo S and Tanaka H 2011 Scr. Mater. 64 765 [21] Hu C, Sakka Y, Nishimura T, Guo S, Grasso S and Tanaka H 2011 Sci. Technol. Adv. Mater. 12 044603 [22] Kakisawa H and Sumitomo T 2011 Sci. Technol. Adv. Mater. 12 064710 [23] Grasso S, Hu C F, Maizza G, Kim B N and Sakka Y 2011 J. Am. Ceram. Soc. 94 1405 [24] Grasso S, Kim B N, Hu C F, Maizza G and Sakka Y 2010 J. Am. Ceram. Soc. 93 2460 [25] Zhang H B, Kim B N, Morita K

  6. Hybrid light emitting transistors (Presentation Recording)

    Science.gov (United States)

    Muhieddine, Khalid; Ullah, Mujeeb; Namdas, Ebinazar B.; Burn, Paul L.

    2015-10-01

    Organic light-emitting diodes (OLEDs) are well studied and established in current display applications. Light-emitting transistors (LETs) have been developed to further simplify the necessary circuitry for these applications, combining the switching capabilities of a transistor with the light emitting capabilities of an OLED. Such devices have been studied using mono- and bilayer geometries and a variety of polymers [1], small organic molecules [2] and single crystals [3] within the active layers. Current devices can often suffer from low carrier mobilities and most operate in p-type mode due to a lack of suitable n-type organic charge carrier materials. Hybrid light-emitting transistors (HLETs) are a logical step to improve device performance by harnessing the charge carrier capabilities of inorganic semiconductors [4]. We present state of the art, all solution processed hybrid light-emitting transistors using a non-planar contact geometry [1, 5]. We will discuss HLETs comprised of an inorganic electron transport layer prepared from a sol-gel of zinc tin oxide and several organic emissive materials. The mobility of the devices is found between 1-5 cm2/Vs and they had on/off ratios of ~105. Combined with optical brightness and efficiencies of the order of 103 cd/m2 and 10-3-10-1 %, respectively, these devices are moving towards the performance required for application in displays. [1] M. Ullah, K. Tandy, S. D. Yambem, M. Aljada, P. L. Burn, P. Meredith, E. B. Namdas., Adv. Mater. 2013, 25, 53, 6213 [2] R. Capelli, S. Toffanin, G. Generali, H. Usta, A. Facchetti, M. Muccini, Nature Materials 2010, 9, 496 [3] T. Takenobu, S. Z. Bisri, T. Takahashi, M. Yahiro, C. Adachi, Y. Iwasa, Phys. Rev. Lett. 2008, 100, 066601 [4] H. Nakanotani, M. Yahiro, C. Adachi, K. Yano, Appl. Phys. Lett. 2007, 90, 262104 [5] K. Muhieddine, M. Ullah, B. N. Pal, P. Burn E. B. Namdas, Adv. Mater. 2014, 26,37, 6410

  7. Photoinduced Electron Transfer in the Strong Coupling Regime: Waveguide-Plasmon Polaritons.

    Science.gov (United States)

    Zeng, Peng; Cadusch, Jasper; Chakraborty, Debadi; Smith, Trevor A; Roberts, Ann; Sader, John E; Davis, Timothy J; Gómez, Daniel E

    2016-04-13

    Reversible exchange of photons between a material and an optical cavity can lead to the formation of hybrid light-matter states where material properties such as the work function [ Hutchison et al. Adv. Mater. 2013 , 25 , 2481 - 2485 ], chemical reactivity [ Hutchison et al. Angew. Chem., Int. Ed. 2012 , 51 , 1592 - 1596 ], ultrafast energy relaxation [ Salomon et al. Angew. Chem., Int. Ed. 2009 , 48 , 8748 - 8751 ; Gomez et al. J. Phys. Chem. B 2013 , 117 , 4340 - 4346 ], and electrical conductivity [ Orgiu et al. Nat. Mater. 2015 , 14 , 1123 - 1129 ] of matter differ significantly to those of the same material in the absence of strong interactions with the electromagnetic fields. Here we show that strong light-matter coupling between confined photons on a semiconductor waveguide and localized plasmon resonances on metal nanowires modifies the efficiency of the photoinduced charge-transfer rate of plasmonic derived (hot) electrons into accepting states in the semiconductor material. Ultrafast spectroscopy measurements reveal a strong correlation between the amplitude of the transient signals, attributed to electrons residing in the semiconductor and the hybridization of waveguide and plasmon excitations. PMID:26963038

  8. Chinese herbal medicine combined with nucleotide analogues for compensated HBV-related cirrhosis: a systematic review of randomized controlled trials

    Directory of Open Access Journals (Sweden)

    Tingting Li

    2015-01-01

    Conclusions: A positive effect was found for FFBJ plus ETV, DHZC plus ADV, and FZHY plus ADV on HA; FZHY plus ADV and FFBJ plus ADV on LN; and FZHY plus ADV on PCIII compared with the effects of NAs used alone.

  9. Colossal dielectric constant in high entropy oxides

    Energy Technology Data Exchange (ETDEWEB)

    Berardan, David; Franger, Sylvain; Dragoe, Diana; Meena, Arun Kumar; Dragoe, Nita [ICMMO (UMR 8182 CNRS), Universite Paris-Sud, Universite Paris-Saclay, 91405, Orsay (France)

    2016-04-15

    Entropic contributions to the stability of solids are very well understood and the mixing entropy has been used for forming various solids, for instance such as inverse spinels, see Nawrotsky et al., J. Inorg. Nucl. Chem. 29, 2701 (1967) [1]. A particular development was related to high entropy alloys by Yeh et al., Adv. Eng. Mater. 6, 299 (2004) [2] and Cantor et al., Mater. Sci. Eng. A 375-377, 213 (2004) [3] (for recent reviews see Zhang et al., Prog. Mater. Sci. 61, 1 (2014) [4] and Tsai et al., Mater. Res. Lett. 2, 107 (2014) [5]) in which the configurational disorder is responsible for forming simple solid solutions and which are thoroughly studied for various applications especially due to their mechanical properties, e.g. Gludovatz et al., Science 345, 1153 (2014) [6] and Lu et al., Sci. Rep. 4, 6200 (2014) [7], but also electrical properties, Kozelj et al., Phys. Rev. Lett. 113, 107001 (2014) [8], hydrogen storage, Kao et al., Int. J. Hydrogen Energy 35, 9046 (2010) [9], magnetic properties, Zhang et al., Sci. Rep. 3, 1455 (2013) [10]. Many unexplored compositions and properties still remain for this class of materials due to their large phase space. In a recent report it has been shown that the configurational disorder can be used for stabilizing simple solid solutions of oxides, which should normally not form solid solutions, see Rost et al., Nature Commun. 6, 8485 (2015) [11] these new materials were called ''entropy-stabilized oxides''. In this pioneering report, it was shown that mixing five equimolar binary oxides yielded, after heating at high temperature and quenching, an unexpected rock salt structure compound with statistical distribution of the cations in a face centered cubic lattice. Following this seminal study, we show here that these high entropy oxides (named HEOx hereafter) can be substituted by aliovalent elements with a charge compensation mechanism. This possibility largely increases the potential development of new

  10. Corrigendum to "Dynamics of a flexible tethered satellite system utilising various materials for coplanar and non-coplanar models" [Adv. Space Res. 56 (2015) 648-663

    Science.gov (United States)

    Hong, Aaron Aw Teik; Varatharajoo, Renuganth

    2015-12-01

    The authors would like to thank Dr. N.A. Ismail for some of the discussions found in her thesis as these discussions have facilitated to achieve some of the results published in this article. Therefore, Ismail, N.A., "The Dynamics of a Flexible Motorised Momentum Exchange Tether (MMET)", PhD. thesis, University of Glasgow, UK, pp. 26-41, 2012 is cited accordingly herein. The thesis was missed out from the reference list in the original version of this article due to an oversight with no other intention. Similarly the thesis by Stevens, R.E., "Optimal Control of Electrodynamic Tether Satellites", PhD. thesis, Air Force Institute of Technology, USA, pp. 87-96, 2008 is referred for a further readership completeness.

  11. Simulaid: a simulation facilitator and analysis program.

    Science.gov (United States)

    Mezei, Mihaly

    2010-11-15

    Simulaid performs a large number of simulation-related tasks: interconversion and modification of structure and trajectory files, optimization of orientation, and a large variety of analysis functions. The program can handle structures in PDB (Berman et al., Nucleic Acids Res 2000, 28, 235), Charmm (Brooks et al., J Comput Chem 4, 187) CRD, Amber (Case et al.), Macromodel (Mohamadi et al., J Comput Chem 1990, 11, 440), Gromos/Gromacs (Hess et al.), InsightII (InsightII. Accelrys Inc.: San Diego, 2005), Grasp (Nicholls et al., Proteins: Struct Funct Genet 1991, 11, 281) .crg, Tripos (Tripos International, S. H. R., St. Louis, MO) .mol2 (input only), and in the MMC (Mezei, M.; MMC: Monte Carlo program for molecular assemblies. Available at: http://inka.mssm.edu/~mezei/mmc) formats; and trajectories in the formats of Charmm, Amber, Macromodel, and MMC. Analysis features include (but are not limited to): (1) simple distance calculations and hydrogen-bond analysis, (2) calculation of 2-D RMSD maps (produced both as text file with the data and as a color-coded matrix) and cross RMSD maps between trajectories, (3) clustering based on RMSD maps, (4) analysis of torsion angles, Ramachandran (Ramachandran and Sasiskharan, Adv Protein Chem 1968, 23, 283) angles, proline kink (Visiers et al., Protein Eng 2000, 13, 603) angles, pseudorotational (Altona and Sundaralingam, J Am Chem Soc 1972, 94, 8205; Cremer and Pople, J Am Chem Soc 1975, 97, 1354) angles, and (5) analysis based on circular variance (Mezei, J Mol Graphics Model 2003, 21, 463). Torsion angle evolutions are presented in dial plots (Ravishanker et al., J Biomol Struct Dyn 1989, 6, 669). Several of these features are unique to Simulaid. PMID:20740566

  12. Review of corrosion behavior of ceramic heat exchanger materals: Corrosion characteristics of silicon carbide and silicon nitride. Final report, September 11, 1992--March 11, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Munro, R.G.; Dapkunas, S.J.

    1993-09-01

    The present work is a review of the substantial effort that has been made to measure and understand the effects of corrosion with respect to the properties, performance, and durability of various forms of silicon carbide and silicon nitride. The review encompasses corrosion in diverse environments, usually at temperatures of 1000C or higher. The environments include dry and moist oxygen, mixtures of hot gaseous vapors, molten salts, molten metals, and complex environments pertaining to coal ashes and slags.

  13. Celulares: a emergência de um novo tipo de controle materno Cell phones: the emergence of a new king of materal control

    Directory of Open Access Journals (Sweden)

    Ana Maria Nicolaci-da-Costa

    2006-12-01

    Full Text Available Em uma pesquisa exploratória sobre o uso de celulares por jovens das camadas médias cariocas, entre 18 e 25 de idade, foi constatado que eles reclamavam muito que suas mães os controlavam ininterruptamente por meio de seus celulares. Para averiguar mais detalhadamente o que acontece entre mães e filhos dessa faixa etária, foi realizada uma segunda pesquisa. Nesta, foram entrevistadas 20 mães, também pertencentes às camadas médias cariocas, cujos filhos tinham perfil análogo ao dos jovens da primeira pesquisa. Para todas, a principal função dos celulares é abertamente a de controlar os filhos. Elas mostraram, no entanto, saber que há uma diferença entre o controle que vigorava quando eram jovens e aquele ao qual hoje submetem os filhos. Teorias contemporâneas sobre controle e vigilância de fato argumentam que houve uma substituição do controle normativo e coercitivo da modernidade pelo "ter conhecimento" do que se passa, característico da Era da Informação.An exploratory research on the use of cell phones by middle-class youngsters, ages 18 to 25, residing in Rio de Janeiro, revealed that they complained a great deal that their mothers controlled them unrelentingly by means of cell phones. To take a deeper look into what happens between mothers and children in this age group, a second investigation was carried out. Twenty middle-class mothers were interviewed, whose children's profile were analogous to that of the youngsters in the previous research. For all of the mothers, the main benefit of cell phones is to control their children. Nevertheless, they demonstrated to know that there's a difference between the control that they submit their children to from that that prevailed when they themselves were young. Contemporary control and surveillance theories, in fact, argue that the normative and coercive control of modernity has been replaced by "having knowledge" of what goes on, which is characteristic of the Information Era.

  14. Acute Pain Service: A New Service of the Humanitas Mater Domini. Pain Management and Listening to the Patient for an Outcome of Quality

    OpenAIRE

    Tzannis Alessandra

    2012-01-01

    Although quality has long been debated in service industry starting from different models developed with respect to goods, there is still room for further investigation on service quality, especially on the definition and the identification of the dimensions of it through performance indicators, the development of tools for measuring it and the analysis of customer satisfaction as a criterion for evaluation. Service quality is also particularly important in fast changing environments. In this...

  15. 冻干辐照猪硬脑膜的抗原性%Antigenicity of freeze-dried irradiated pig dura mater

    Institute of Scientific and Technical Information of China (English)

    张友来; 曾元临; 邹立津; 辛国华

    2010-01-01

    背景:抗原性是异种组织移植最主要的问题,是移植成功与否的关键.目的:观察经冻干辐照处理后的猪硬脑膜抗原性变化.方法:取新鲜猪硬脑膜,经冻干、辐照处理后分别制备成冻干猪硬脑膜、辐照猪硬脑膜和冻干辐照猪硬脑膜.分别移植于大白兔硬脑膜上,于术后3,8周行各组实验动物淋巴细胞毒实验.结果与结论:移植冻干组和辐照组淋巴细胞死亡率比较差异无显著性意义(P>0.05),但均高于冻干辐照组(P<0.05).结果提示经冻干辐照处理后的猪硬脑膜抗原性低.

  16. Drug: D01421 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available purate sodium; Paraaminohippurate (TN) C9H9N2O3. Na 216.0511 216.1691 D01421.gif Diagnostic aid [renal funct...ly for therapeutic purpose 72 Intracorporeal diagnostic agents 722 Various function testing reagents 7225 Diagnostic

  17. A cohesive plastic/damage-zone model for ductile crack analysis

    International Nuclear Information System (INIS)

    A cohesive plastic/damage-zone model of the Dugdale-Barenblatt type (G.I. Barenblatt, Adv. Appl. Mech. 7 (1962) 55-129; D.S. Dugdale, J. Mech. Phys. Solids 8 (1960) 100-104) is presented for analyzing crack growth in ductile materials with damage evolution. A semi-infinite Mode I crack in plane stress or plane stress is considered. The damage is assumed to be present in form of dispersed microvoids which are localized into a narrow strip ahead of the crack-tip. A simple damage model of the Gurson model type (A.L. Gurson, J. Eng. Mater. Technol. 99 (1977) 2-15; V. Tvergaard, Advances in Applied Mechanics, Vol. 27, Academic Press, 1990, pp. 83-151) is developed for uniaxial tension to describe the macroscopic properties of the cohesive plastic/damage-zone. Under small-scale yielding and small-scale damage conditions, a system of nonlinear integral equations for the plastic strain and the length of the cohesive plastic/damage-zone is derived. Numerical results are presented and discussed to reveal the effect of damage evolution on the ductile crack growth. (orig.)

  18. Molecular structure of the discotic liquid crystalline phase of hexa-peri-hexabenzocoronene/oligothiophene hybrid and their charge transport properties

    International Nuclear Information System (INIS)

    Using atomistic molecular dynamics simulation, we study the discotic columnar liquid crystalline (LC) phases formed by a new organic compound having hexa-peri-Hexabenzocoronene (HBC) core with six pendant oligothiophene units recently synthesized by Nan Hu et al. [Adv. Mater. 26, 2066 (2014)]. This HBC core based LC phase was shown to have electric field responsive behavior and has important applications in organic electronics. Our simulation results confirm the hexagonal arrangement of columnar LC phase with a lattice spacing consistent with that obtained from small angle X-ray diffraction data. We have also calculated various positional and orientational correlation functions to characterize the ordering of the molecules in the columnar arrangement. The molecules in a column are arranged with an average twist of 25° having an average inter-molecular separation of ∼5 Å. Interestingly, we find an overall tilt angle of 43° between the columnar axis and HBC core. We also simulate the charge transport through this columnar phase and report the numerical value of charge carrier mobility for this liquid crystal phase. The charge carrier mobility is strongly influenced by the twist angle and average spacing of the molecules in the column

  19. Molecular structure of the discotic liquid crystalline phase of hexa-peri-hexabenzocoronene/oligothiophene hybrid and their charge transport properties

    Energy Technology Data Exchange (ETDEWEB)

    Bag, Saientan; Maingi, Vishal; Maiti, Prabal K., E-mail: maiti@physics.iisc.ernet.in [Department of Physics, Center for Condensed Matter Theory, Indian Institute of Science, Bangalore 560012 (India); Yelk, Joe; Glaser, Matthew A.; Clark, Noel A. [Department of Physics, University of Colorado, Boulder, Colorado 80309 (United States); Walba, David M. [Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309 (United States)

    2015-10-14

    Using atomistic molecular dynamics simulation, we study the discotic columnar liquid crystalline (LC) phases formed by a new organic compound having hexa-peri-Hexabenzocoronene (HBC) core with six pendant oligothiophene units recently synthesized by Nan Hu et al. [Adv. Mater. 26, 2066 (2014)]. This HBC core based LC phase was shown to have electric field responsive behavior and has important applications in organic electronics. Our simulation results confirm the hexagonal arrangement of columnar LC phase with a lattice spacing consistent with that obtained from small angle X-ray diffraction data. We have also calculated various positional and orientational correlation functions to characterize the ordering of the molecules in the columnar arrangement. The molecules in a column are arranged with an average twist of 25° having an average inter-molecular separation of ∼5 Å. Interestingly, we find an overall tilt angle of 43° between the columnar axis and HBC core. We also simulate the charge transport through this columnar phase and report the numerical value of charge carrier mobility for this liquid crystal phase. The charge carrier mobility is strongly influenced by the twist angle and average spacing of the molecules in the column.

  20. 国外文献速报

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Gunduz M,Cadirli E.Pb-Sn合金的定向凝固(英).J.Mater.Sci.,2000,35 (15):3837~3848 040113 Nave M D,Dahle A K,John D H St.凝固速度对镁合金共晶晶粒组织的影响(英).Int.J.Cast Met.Res.,2000,13 (1):1~7 040114 Martorano M A,Capoccli J D T.定向凝固青铜铸件枝晶组织的控制(英).Int.J.Cast Met.Res.,2000,13(1): 49~57 040115 Zhang Y L,Li Q,Li Y X.NiAl形状记忆合金的单晶生长(英).Prog.Cryst.Growth Charact.Mater.,2000,4(1-4): 309~314 040116 Cheng T T.TiAl合金中添加B细化晶粒的机理-- 一种可选择的假设(英).Intermatallics,2000,8(1): 29~31 040117 Pao P S,Feng C K,Gill S J.关于7075-T7351合金从腐蚀凹坑开始时的裂纹(英).Scr.Mater.,2000,43(5):391~396 040118 Hilpert M,Wagner L.高强度镁合金AZ80的腐蚀疲劳行为(英).J.Mater.Eng.Perform.,2000,9(4): 402~407 040119 Sasaki G,Fukunaga H,Yoshida M.镁基复合材料的制造工艺及微观组织分析(英).Mater.Jpn.,2000,39(6): 519~525 040120 Kosec B,Bizjak M,Kosec L.两相铜基材料拉伸变形的宏观模拟(英).Metall.2000,69(5):384~386 040121 Machovec C J,Zindel J W,Godlewski L A.Bi-Sr复合变质对319铝合金中Si形态影响的效果分析(英).Mod.Cast.,2000(6):42~44 040122 Maeng D Y,Chun B S,Hong H J.快速凝固挤压Mg-Zn合金的组织和强度(英).Scr.Mater.,2000,43(5):385~389 040123 Kim H G,Kim J Y,Cho Y T.预应变对形状记忆合金弹性的影响分析研究(英).Key Eng.Mater.,2000 (2):1219~1224 040124 Cho W D,Kim I,Kim H J.含Y的Fe3Al的高温氧化(英).J.Mater.Sci.,2000,35 (18): 4695~4703 金属基复合材料 040201 Hirai H,Kitahara A,Tabarn T.定向凝固No-xMo-22Ti-18Si原位(In-Stiu)复合材料的组织和力学性能(日).J.Jpn.Inst.Met.,2000,64(6): 474~480 040202 Korner C,Ottmuller M,Schaff W.碳长纤维增强镁基复合材料(英).Adv.Eng.Mater.,2000,2(6): 327~337 040203 Naplocha K,Samsonowicz Z.AlSi9Mg基Al2O3短纤维增强复合材料(葡).Przegl.Odlew.,2000,50(4):127~130 040204 Lee J C

  1. "La Iglesia, vaso siempre joven del Espíritu de Dios" (Adv. haer. 111,24, 1: Reflexiones sobre el núcleo articulador de la eclesiología de San Ireneo de Lyon

    Directory of Open Access Journals (Sweden)

    Rodrigo Polanco F

    2007-01-01

    Full Text Available El autor presenta el núcleo articulador de la eclesiología de San Ireneo. Frente a la teología gnóstica que negaba la bondad de la creación, y particularmente la corporalidad (carne humana, Ireneo presenta una eclesiología que es consecuencia de su cristología y antropología que valoran tanto al hombre en su corporalidad, como la realidad de la encarnación. En consecuencia, la eclesiología de Ireneo se fundamenta en la bondad de la institución eclesial que es instrumento del Espíritu. El Espíritu de Cristo se hace presente a través de los carismas y de la sucesión apostólica que transmiten la comun1Cación auténtica de Cristo. Es en síntesis una eclesiología del Espíritu encarnado en la estructura de la Iglesia, Espíritu que hace a esta misma Iglesia fiable y fiel al mensaje y persona de JesucristoThe author presents the articulating nucleus of the ecclesiology of St. Irenaeus. In the context of Gnostic theology that denies the goodness of creation, and particularly of human (flesh corporality, Irenaeus presents an ecclesiology that is a consequence of his Christology and his anthropology, which values man as much in his corporality as in the reality of the Incarnation. As a consequence, Irenaeus' ecclesiology is founded upon the goodness of the ecclesial institution that is an instrument of the Spirit. The Spirit of Christ makes itself present through charisms and through the apostol1C succession, that transmit the authentic commun1Cation of Christ. In synthesis, it is an ecclesiology of the Spirit incarnated in the structure of the Church, Spirit that makes this same Church worthy of trust and faithful to the message and person of Jesus Christ

  2. "La Iglesia, vaso siempre joven del Espíritu de Dios" (Adv. haer. 111,24, 1): Reflexiones sobre el núcleo articulador de la eclesiología de San Ireneo de Lyon

    OpenAIRE

    Rodrigo Polanco F

    2007-01-01

    El autor presenta el núcleo articulador de la eclesiología de San Ireneo. Frente a la teología gnóstica que negaba la bondad de la creación, y particularmente la corporalidad (carne) humana, Ireneo presenta una eclesiología que es consecuencia de su cristología y antropología que valoran tanto al hombre en su corporalidad, como la realidad de la encarnación. En consecuencia, la eclesiología de Ireneo se fundamenta en la bondad de la institución eclesial que es instrumento del Espíritu. El Esp...

  3. New treatment option for women with hormone-sensitive breast cancer

    Science.gov (United States)

    A drug used for treating breast cancer, known as exemestane, is more effective than a common breast cancer prevention drug, tamoxifen, in preventing breast cancer recurrence in young women who also receive post-surgical treatment to suppress ovarian funct

  4. InterProScan Result: FS736777 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 05804 Fatty acid desaturase, type 1 Biological Process: lipid metabolic process (GO:0006629)|Molecular Funct...ion: oxidoreductase activity (GO:0016491)|Biological Process: oxidation reduction (GO:0055114) ...

  5. NEUROLOGICAL DISORDER

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    13.1 Neuroanatomy, Neurophysiology and Neuropathology2007131 Study on decision-making alternation after bilateral nucleus accumbens ablation in drug addicts. HOU Yuan-zheng(侯远征),et al. Dept Neurosurg, Instit Funct Neurosurg, Instit Funct Cerebullar Dis, Tangdu Hosp, 4th Milit Med Univ, Xi′an 710038. Chin J Nerv Ment Dis 2006;32(6)494-497. Objective To explore decision-making alternation after bilateral nucleus accumbens ablation in drug addicts and analyse the reason.

  6. Ab initio study of antiphase boundaries and stacking faults in L12 and DO22 compounds

    DEFF Research Database (Denmark)

    Rosengaard, N. M.; Skriver, Hans Lomholt

    1994-01-01

    We have performed ab initio calculations of the energies of antiphase boundaries as well as complex and superlattice intrinsic stacking faults in nine intermetallic compounds observed in the face-centered-cubic L1(2) and DO22 structures. The calculations were performed by means of a Green's funct......'s function technique based on the linear-muffin-tin-orbitals method within the tight-binding and atomic-sphere approximations....

  7. Курсивы про Alma Mater как точку возврата

    OpenAIRE

    Исхаков, Р. Л.; Iskhakov, R. L.

    2014-01-01

    Автор, опираясь на книги воспоминаний выпускников факультета журналистики УрГУ 1975–1977 гг., показывает эпистемологические возможности такого исследовательского направления, как «биографика»: рассматривает его использование для преодоления кризиса историографии журналистики, восстановления истории журналистики как повседневного бытописания и для описания менталитета журналистского сообщества....

  8. 播种方式对大豆干物质积累与产量影响的研究%Effect of Sowing Methods on Dry Mater Accumulation and Yield in Soybean

    Institute of Scientific and Technical Information of China (English)

    徐文平; 苗兴芬; 任学坤; 申宏波

    2008-01-01

    试验采用5个处理,3次重复,研究了不同播种方式对大豆干物质积累与产量的影响.结果表明:穴距18 cm,每穴3株的播种方式对于干物质的积累较为合适.不同处理对大豆产量性状的影响不同,穴距18 cm,每穴3株的播种方式大豆产量最高,大豆产量与株高、主茎节数、单株生产力及单株荚数呈正相关,而与百粒重呈不显著的负相关.

  9. 弱光胁迫对超级杂交稻产量和干物质积累的影响%Effects of weak light stress on grain yield and dry mater accumulation of super hybrid rice

    Institute of Scientific and Technical Information of China (English)

    刘科; 何爱斌; 苑涛涛; 田小海; 张运波

    2014-01-01

    超级杂交稻在山丘地区的生态条件下容易展示超高产潜力,但在平原地区由于光照相对较少和灌浆期间的多阴寡照天气造成严重减产.以超级杂交稻、普通杂交稻和高产常规稻代表品种为供试材料,在齐穗后设置过滤30%光照、60%光照和对照3个处理,探讨不同遮光处理对超级杂交稻产量和干物质积累的影响.结果表明:超级杂交稻对弱光反应敏感,品种和遮光处理之间互作效应显著,齐穗后遮光处理对超级杂交稻结实率和千粒重影响显著、产量下降24.2%~52.8%,对每穗粒数和有效穗数影响不显著;齐穗后遮光处理对超级杂交稻干物质积累影响显著,收获指数显著下降,特别是后期干物质积累量占总干物质比例显著下降,影响后期干物质的积累和转化.

  10. Osteogenic differentiation of dura mater stem cells cultured in vitro on three-dimensional porous scaffolds of poly(ε-caprolactone) fabricated via co-extrusion and gas foaming

    OpenAIRE

    Aronin, C.E. Petrie; Cooper, J. A.; Sefcik, L.S.; Tholpady, S.S.; Ogle, R.C.; Botchwey, E. A.

    2008-01-01

    A novel scaffold fabrication method utilizing both polymer blend extrusion and gas foaming techniques to control pore size distribution is presented. Seventy five per cent of all pores produced using polymer blend extrusion alone were less than 50 μm. Introducing a gas technique provided better control of pore size distribution, expanding the range from 0-50 to 0-350 μm. Varying sintering time, annealing temperature and foaming pressure also helped reduced the percentage of pore sizes below 5...

  11. Central limit theorem for integrated square error of kernel estimators of spherical density

    Institute of Scientific and Technical Information of China (English)

    ZHAO; Lincheng

    2001-01-01

    [1] Cruzeiro, A. B., Malliavin, P., Renormalized differential geometry on path spaces: Structural equation, curvature, J. Funct. Anal., 1996, 139: 119-181.[2] Stroock, D. W., Some thoughts about Riemannian structures on path spaces, preprint, 1996.[3] Driver, B., A Cameron-Martin type quasi-invariance theorem for Brownian motion on a compact manifold, J. Funct. Anal., 1992, 109: 272-376.[4] Enchev, O., Stroock, D. W., Towards a Riemannian geometry on the path space over a Riemannian manifold, J. Funct. Anal., 1995, 134: 392-416.[5] Hsu, E., Quasi-invariance of the Wiener measure on the path space over a compact Riemannian manifold, J. Funct. Anal., 1995, 134: 417-450.[6] Lyons, T. J., Qian, Z. M., A class of vector fields on path space, J.Funct. Anal., 1997, 145: 205-223.[7] Li, X. D., Existence and uniqueness of geodesics on path spaces, J. Funct. Anal., to be published.[8] Driver, B., Towards calculus and geometry on path spaces, in Proc. Symp. Pure and Appl. Math. 57 (ed. Cranston, M., Pinsky, M.), Cornell: AMS, 1993, 1995.

  12. Geodesic flows on path spaces

    Institute of Scientific and Technical Information of China (English)

    XIANG; Kainan

    2001-01-01

    [1] Cruzeiro, A. B., Malliavin, P., Renormalized differential geometry on path spaces: Structural equation, curvature, J. Funct. Anal., 1996, 139: 119-181.[2] Stroock, D. W., Some thoughts about Riemannian structures on path spaces, preprint, 1996.[3] Driver, B., A Cameron-Martin type quasi-invariance theorem for Brownian motion on a compact manifold, J. Funct. Anal., 1992, 109: 272-376.[4] Enchev, O., Stroock, D. W., Towards a Riemannian geometry on the path space over a Riemannian manifold, J. Funct. Anal., 1995, 134: 392-416.[5] Hsu, E., Quasi-invariance of the Wiener measure on the path space over a compact Riemannian manifold, J. Funct. Anal., 1995, 134: 417-450.[6] Lyons, T. J., Qian, Z. M., A class of vector fields on path space, J.Funct. Anal., 1997, 145: 205-223.[7] Li, X. D., Existence and uniqueness of geodesics on path spaces, J. Funct. Anal., to be published.[8] Driver, B., Towards calculus and geometry on path spaces, in Proc. Symp. Pure and Appl. Math. 57 (ed. Cranston, M., Pinsky, M.), Cornell: AMS, 1993, 1995.

  13. Virus Infection

    Directory of Open Access Journals (Sweden)

    Hiroshi Abe

    2013-01-01

    Full Text Available Of 168 patients with chronic hepatitis B virus (HBV infection-related liver disease, 20 patients who had received 100 mg of lamivudine plus 10 mg/day of adefovir dipivoxil (ADV (ADV group and 124 patients who had received 0.5 mg/day of entecavir or 100 mg/day of lamivudine (non-ADV group for >1 year were enrolled. For comparative analyses, 19 well-matched pairs were obtained from the groups by propensity scores. At the time of enrollment, serum creatinine and phosphate concentrations were similar between the ADV and non-ADV groups; however, urinary phosphate ( and serum bone-specific alkaline phosphatase (BAP ( concentrations were significantly higher in the ADV group than in the non-ADV group. Serum BAP was significantly higher at the time of enrollment than before ADV administration in the ADV group (, although there was no significant change in serum BAP concentration in the non-ADV group. There was a significant positive correlation between the period of ADV therapy and ΔBAP (, . Serum BAP concentration increased before increase in serum creatinine concentration and was useful for early detection of adverse events and for developing adequate measures for continuing ADV for chronic HBV infection-related liver disease.

  14. Adolescent Dating Violence Prevention and Intervention in a Community Setting: Perspectives of Young Adults and Professionals

    Science.gov (United States)

    Martsolf, Donna S.; Colbert, Crystal; Draucker, Claire B.

    2012-01-01

    Adolescent dating violence (ADV) is a significant community problem. In this study, we examine the perspectives of two groups (young adults who experienced ADV as teens and professionals who work with teens) on ADV prevention/intervention in a community context. We interviewed 88 young adults and 20 professionals. Our research team used Thorne's…

  15. Investigation of the pathogenesis of transplacental transmission of Aleutian mink disease parvovirus in experimentally infected mink

    DEFF Research Database (Denmark)

    Broll, S.; Alexandersen, Søren

    1996-01-01

    The transplacental transmission of Aleutian mink disease parvovirus (ADV) was studied in experimental infection of 1-year-old female non-Aleutian mink. The ADV-seronegative female mink were inoculated,vith ADV prior to mating or after the expected implantation of the embryos during pregnancy. A...

  16. S-phase-dependent cell cycle disturbances caused by Aleutian mink disease parvovirus

    DEFF Research Database (Denmark)

    Oleksiewicz, M.B.; Alexandersen, Søren

    1997-01-01

    We examined replication of the autonomous parovirus Aleutian mink disease parovirus (ADV) in relation to cell cycle progression of permissive Crandell feline kidney (CRFK) cells. Flow cytometric analysis showed that ADV caused a composite, binary pattern of cell cycle arrest. ADV-induced cell cyc...

  17. Three-dimensional cell culture of chondrocytes on modified di-phenylalanine scaffolds.

    Science.gov (United States)

    Jayawarna, V; Smith, A; Gough, J E; Ulijn, R V

    2007-06-01

    The design of self-assembled peptide-based structures for three-dimensional cell culture and tissue repair has been a key objective in biomaterials science for decades. In search of the simplest possible peptide system that can self-assemble, we discovered that combinations of di-peptides that are modified with aromatic stacking ligands could form nanometre-sized fibres when exposed to physiological conditions. For example, we demonstrated that a number of Fmoc (fluoren-9-ylmethyloxycarbonyl) modified di- and tri-peptides form highly ordered hydrogels via hydrogen-bonding and pi-pi interactions from the fluorenyl rings. These highly hydrated gels allowed for cell proliferation of chondrocytes in three dimensions [Jayawarna, Ali, Jowitt, Miller, Saiani, Gough and Ulijn (2006) Adv. Mater. 18, 611-614]. We demonstrated that fibrous architecture and physical properties of the resulting materials were dictated by the nature of the amino acid building blocks. Here, we report the self-assembly process of three di-phenylalanine analogues, Fmoc-Phe-Phe-OH, Nap (naphthalene)-Phe-Phe-OH and Cbz (benzyloxycarbonyl)-Phe-Phe-OH, to compare and contrast the self-assembly properties and cell culture conditions attributable to their protecting group difference. Fibre morphology analysis of the three structures using cryo-SEM (scanning electron microscopy) and TEM (transmission electron microscopy) suggested fibrous structures with dramatically varying fibril dimensions, depending on the aromatic ligand used. CD and FTIR (Fourier-transform IR) data confirmed beta-sheet arrangements in all three samples in the gel state. The ability of these three new hydrogels to support cell proliferation of chondrocytes was confirmed for all three materials. PMID:17511646

  18. Defects responsible for abnormal n-type conductivity in Ag-excess doped PbTe thermoelectrics

    International Nuclear Information System (INIS)

    Density functional calculations have been performed to investigate the role of Ag defects in PbTe thermoelectric materials. Ag-defects can be either donor, acceptor, or isovalent neutral defect. When Ag is heavily doped in PbTe, the neutral (Ag-Ag) dimer defect at Pb-site is formed and the environment changes to the Pb-rich/Te-poor condition. Under Pb-rich condition, the ionized Ag-interstitial defect (AgI+) becomes the major donor. The formation energy of AgI+ is smaller than other native and Ag-related defects. Also it is found that AgI+ is an effective dopant. There is no additional impurity state near the band gap and the conduction band minimum. The charge state of AgI+ defect is maintained even when the Fermi level is located above the conduction band minimum. The diffusion constant of AgI+ is calculated based on the temperature dependent Fermi level, formation energy, and migration energy. When T > 550 K, the diffusion length of Ag within a few minutes is comparable to the grain size of the polycrystalline PbTe, implying that Ag is dissolved into PbTe and this donor defect is distributed over the whole lattice in Ag-excess doped polycrystalline PbTe. The predicted solubility of AgI+ well explains the increased electron carrier concentration and electrical conductivity reported in Ag-excess doped polycrystalline PbTe at T = 450–750 K [Pei et al., Adv. Energy Mater. 1, 291 (2011)]. In addition, we suggest that this abnormal doping behavior is also found for Au-doped PbTe

  19. Plasma enhanced atomic layer batch processing of aluminum doped titanium dioxide

    Energy Technology Data Exchange (ETDEWEB)

    Lehnert, Wolfgang; Ruhl, Guenther; Gschwandtner, Alexander [Infineon Technologies AG, Wernerwerkstrasse 2, Regensburg, 93049 (Germany); R3T GmbH, Hochstrasse 1, Taufkirchen, 82024 (Germany)

    2012-01-15

    Among many promising high-k dielectrics, TiO{sub 2} is an interesting candidate because of its relatively high k value of over 40 and its easy integration into existing semiconductor manufacturing schemes. The most critical issues of TiO{sub 2} are its low electrical stability and its high leakage current density. However, doping TiO{sub 2} with Al has shown to yield significant improvement of layer quality on Ru electrodes [S. K. Kim et al., Adv. Mater. 20, 1429 (2008)]. In this work we investigated if atomic layer deposition (ALD) of Al doped TiO{sub 2} is feasible in a batch system. Electrical characterizations were done using common electrode materials like TiN, TaN, or W. Additionally, the effect of plasma enhanced processing in this reactor was studied. For this investigation a production batch ALD furnace has been retrofitted with a plasma source which can be used for post deposition anneals with oxygen radicals as well as for directly plasma enhanced ALD. After evaluation of several Ti precursors a deposition process for AlTiO{sub x} with excellent film thickness and composition uniformity was developed. The effects of post deposition anneals, Al{sub 2}O{sub 3} interlayers between electrode and TiO{sub 2}, Al doping concentration, plasma enhanced deposition and electrode material type on leakage current density are shown. An optimized AlTiO{sub x} deposition process on TaN electrodes yields to leakage current density of 5 x 10{sup -7} A/cm{sup 2} at 2 V and k values of about 35. Thus, it could be demonstrated that a plasma enhanced batch ALD process for Al doped TiO{sub 2} is feasible with acceptable leakage current density on a standard electrode material.

  20. Plasma enhanced atomic layer batch processing of aluminum doped titanium dioxide

    International Nuclear Information System (INIS)

    Among many promising high-k dielectrics, TiO2 is an interesting candidate because of its relatively high k value of over 40 and its easy integration into existing semiconductor manufacturing schemes. The most critical issues of TiO2 are its low electrical stability and its high leakage current density. However, doping TiO2 with Al has shown to yield significant improvement of layer quality on Ru electrodes [S. K. Kim et al., Adv. Mater. 20, 1429 (2008)]. In this work we investigated if atomic layer deposition (ALD) of Al doped TiO2 is feasible in a batch system. Electrical characterizations were done using common electrode materials like TiN, TaN, or W. Additionally, the effect of plasma enhanced processing in this reactor was studied. For this investigation a production batch ALD furnace has been retrofitted with a plasma source which can be used for post deposition anneals with oxygen radicals as well as for directly plasma enhanced ALD. After evaluation of several Ti precursors a deposition process for AlTiOx with excellent film thickness and composition uniformity was developed. The effects of post deposition anneals, Al2O3 interlayers between electrode and TiO2, Al doping concentration, plasma enhanced deposition and electrode material type on leakage current density are shown. An optimized AlTiOx deposition process on TaN electrodes yields to leakage current density of 5 x 10-7 A/cm2 at 2 V and k values of about 35. Thus, it could be demonstrated that a plasma enhanced batch ALD process for Al doped TiO2 is feasible with acceptable leakage current density on a standard electrode material.

  1. Magnetoelectric imaging of multiferroic heterostructures (Presentation Recording)

    Science.gov (United States)

    Ghidini, Massimo; Lesaine, Arnaud; Zhu, Bonan; Moya, Xavier; Yan, Wenjing; Crossley, Sam; Nair, Bhasi; Mansell, Rhodri; Cowburn, Russell P.; Barnes, Crispin H. W.; Kronast, Florian; Valencia, Sergio; Maccherozzi, Francesco; Dhesi, Sarnjeet S.; Mathur, Neil

    2015-09-01

    Electrical control of magnetism has been demonstrated in multiferroic compounds and ferromagnetic semiconductors, but electrical switching of a substantial net magnetization at room temperature has not been demonstrated in these materials. This goal has instead been achieved in heterostructures comprising ferromagnetic films in which electrically driven magnetic changes arise due to strain or exchange bias from ferroic substrates, or due to charge effects induced by a gate. However, previous work focused on electrical switching of an in-plane magnetization or involved the assistance of applied magnetic fields. In heterostructures made of juxtaposed ferroelectric and ferromagnetic layers, we have shown electrical control with no applied magnetic field of the perpendicular magnetization of small features [1] and of magnetic stripe domains patterns [2]. Here we investigate Ni81Fe19 films on ferroelectric substrates with and without buffer layers of Cu, whose presence precludes charge-mediated coupling. Ni81Fe19 has virtually zero magnetostriction, but sufficiently thin films show large magnetostriction, and thus, on increasing film thickness through the threshold for zero magnetostriction, we have seeked the crossover from charge- to strain-mediated coupling. We will then show that strain associated with the motion of 90°- ferroelectric domain walls in a BaTiO3 substrate, can switch the magnetization of an array of overlying single-domain Ni dots. [1] M. Ghidini, R. Pellicelli, J. L. Prieto, X. Moya, J. Soussi, J. Briscoe, S. Dunn and N. D. Mathur, Nature Communications 4 (2013) 1453. [2] M. Ghidini, F.Maccherozzi, X. Moya, L. C. Phillips, W.Yan, J. Soussi, N. Métallier, M.Vickers, , N. -J.Steinke, R. Mansell, C. H. W. Barnes, S. S. Dhesi, and N. D. Mathur, Adv. Mater.doi: 10.1002/adma.201404799 (2015).

  2. Mechanical characterization of a bifunctional Tetronic hydrogel adhesive for soft tissues.

    Science.gov (United States)

    Sanders, Lindsey; Stone, Roland; Webb, Kenneth; Mefford, Thompson; Nagatomi, Jiro

    2015-03-01

    Although a number of tissue adhesives and sealants for surgical use are currently available, attaining a useful balance in high strength, high compliance, and low swelling has proven difficult. Recent studies have demonstrated that a four-arm poly(propylene oxide)-poly(ethylene oxide) block copolymer, Tetronic, can be chemically modified to form a hydrogel tissue adhesive (Cho et al., Acta Biomater 2012;8:2223-2232; Barrett et al., Adv Health Mater 2012;1-11; Balakrishnan, Evaluating mechanical performance of hydrogel-based adhesives for soft tissue applications. Clemson University, All Theses, Paper 1574: Tiger Prints; 2013). Building on the success of these studies, this study explored bifunctionalization of Tetronic with acrylates for chemical crosslinking of the hydrogel and N-hydroxysuccinimide (NHS) for reaction with tissue amines. The adhesive bond strengths of various uni and bifunctional Tetronic blends (T1107 ACR: T1107 ACR/NHS) determined by lap shear testing ranged between 8 and 74 kPa, with the 75:25 (T1107 ACR: T1107 ACR/NHS) blend displaying the highest value. These results indicated that addition of NHS led to improvement of tissue bond strength over acrylation alone. Furthermore, ex vivo pressure tests using the rat bladder demonstrated that the bifunctional Tetronic adhesive exhibited high compliance and maintained pressures under hundreds of filling and emptying cycles. Together, the results of this study provided evidence that the bifunctional Tetronic adhesive with a proper blend ratio may be used to achieve an accurate balance in bulk and tissue bond strengths, as well as the compliance and durability for soft tissue such as the bladder. PMID:25111445

  3. Lamivudine-resistant rtL180M and rtM204I/V are persistently dominant during combination rescue therapy with entecavir and adefovir for hepatitis B

    Science.gov (United States)

    WANG, YANG; LIU, SHUANG; CHEN, YU; ZHENG, SUJUN; ZHOU, LI; LU, FENGMIN; DUAN, ZHONGPING

    2016-01-01

    Adefovir (ADV) sequential monotherapy was included in the 2005 Asia-Pacific guidelines for the management of patients with lamivudine (LAM) resistance. However, following the development of ADV resistance, the proportion of resistant variants during combined rescue therapy with ADV and entecavir (ETV) were unknown. The present study characterized the dynamics of resistant variants in patients with chronic hepatitis B (CHB) and LAM-resistant variants during antiviral therapy consisting of ADV monotherapy followed by ADV-ETV combination therapy. A total of 3 patients were selected from a cohort of 55 patients with CHB due to developing ADV resistance. The patients had been previously treated with LAM (100 mg daily) for 21–24 months. At the initiation of sequential monotherapy with ADV, LAM-resistant variants (rtM204V/I and rtL180M) were detected in the three patients. These patients developed ADV resistance during 19–30 months of ADV sequential monotherapy, and then switched their antiviral regimen to ADV-ETV combination therapy. During ADV monotherapy and ADV-ETV combination therapy, the patients were monitored every 3 months for the first year of therapy, and then every 6 months thereafter. A total of 30 serum samples were collected from the patients throughout the monitoring period. In total, 10 mutants that were associated with commonly-used antiviral drugs were detected by pyrosequencing. During ADV sequential monotherapy, LAM-resistant variants were gradually decreased, whereas ADV-resistant rtA181V/T and rtN236T variants gradually increased in the viral population. During 30–41 months of ADV-ETV combination therapy, viral load reduction was 2.59–3.28 log10 copies/ml; ADV-resistant variants rtA181T/V and rtN236T were undetectable following 11–24 months of combination therapy; and rtL180M and rtM204I/V remained dominant in the viral population. In conclusion, the results of the present study suggested that, in patients with LAM and ADV

  4. Quantitative Real-Time PCR Assays for Detection of Human Adenoviruses and Identification of Serotypes 40 and 41

    Science.gov (United States)

    Jothikumar, Narayanan; Cromeans, Theresa L.; Hill, Vincent R.; Lu, Xiaoyan; Sobsey, Mark D.; Erdman, Dean D.

    2005-01-01

    A quantitative real-time TaqMan PCR assay for detection of human adenoviruses (HAdV) was developed using broadly reactive consensus primers and a TaqMan probe targeting a conserved region of the hexon gene. The TaqMan assay correctly identified 56 representative adenovirus prototype strains and field isolates from all six adenovirus species (A to F). Based on infectious units, the TaqMan assay was able to detect as few as 0.4 and 0.004 infectious units of adenovirus serotype 2 (AdV2) and AdV41, respectively, with results obtained in less than 90 min. Using genomic equivalents, the broadly reactive TaqMan assay was able to detect 5 copies of AdV40 (which had zero mismatches with the PCR primers and probe), 8 copies of AdV41, and 350 copies of AdV3 (which had the most mismatches [seven] of any adenovirus serotype tested). For specific detection and identification of F species serotypes AdV40 and AdV41, a second real-time PCR assay was developed using fluorescence resonance energy transfer (FRET) probes that target the adenovirus fiber gene. The FRET-based assay had a detection limit of 3 to 5 copies of AdV40 and AdV41 standard DNA and was able to distinguish between AdV40 and AdV41 based on melting curve analysis. Both the TaqMan and FRET PCR assays were quantitative over a wide range of virus titers. Application of these assays for detection of adenoviruses and type-specific identification of AdV40 and AdV41 will be useful for identifying these viruses in environmental and clinical samples. PMID:15933012

  5. Embedding theorems of Besov and Triebel-Lizorkin spaces on spaces of homogeneous type

    Institute of Scientific and Technical Information of China (English)

    YANG; Dachun(

    2003-01-01

    , Cambridge: Cambridge Univ. Press, 1996.[15]Macias, R. A., Segovia, C., Lipschitz functions on spaces of homogeneous type, Adv. in Math., 1979, 33: 257.[16]Han, Y., Sawyer, E. T., Littlewood-Paley theory on spaces of homogeneous type and classical function spaces,Memoirs Amer. Math. Soc., 1994, 110(530): 1.[17]Han, Y., Inhomogeneous Calderón reproducing formula on spaces of homogeneous type, J. Geometric Anal.,1997, 7: 259.[18]David, G., Journé, J. L., Semmes, S., Opérateurs de Calderón-Zygmund, fonctions para-accrétives et interpolation, Rev. Mat. Iberoamericana, 1985, 1: 1.[19]Christ, M., A T(b) theorem with remarks on analytic capacity and the Cauchy integral, Colloq. Math., 1990,LX/LXI: 601.[20]Triebel, H., Theory of Function Spaces, Basel: Birkhauser Verlag, 1983.[21]Frazier, M., Jawerth, B., A discrete transform and decompositions of distribution spaces, J. Funct. Anal.,1990, 93: 34.[22]Fefferman, C., Stein, E. M., Some maximal inequalities, Amer. J. Math., 1971, 93: 107.

  6. Isotropic bodies and Bourgain's problem

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    [1]Milman, V. D., Pajor, A., Isotropic position and inertia ellipsoid and zonoids of the unit ball of a normed ndimensional space, Geometric aspects of functional analysis (1987-1988), Lecture Notes in Math., 1989, 1376:64-104.[2]Blaschke, W., Uber affine Geometry ⅩⅣ: eine minimum Aufgabe fur Legendres tragheits Ellipsoid, Ber. verh.sachs. Akad. d. Wiss., 1918, 70: 72-75.[3]Blaschke, W., Uber affine Geometry Ⅺ: losing der "Vierpunkproblems" von Sylvester aus der Teorie der geometrischen Wahrsdeinlichkeiten, Leipziger Berichte, 1917, 69: 436-453.[4]John, F., Polar correspondence with respect to convex regions, Duke Math. J., 1937, 3(2): 355-369.[5]Lutwak, E., Yang, D., Zhang, G., A new ellipsoid associated with convex bodes, Duke. Math. J., 2000, 104:375-390.[6]Bourgain, J., On the distribution of polynomails on high dimensional convex sets, Geometric aspects of functional analysis (1989-1990), Lecture Notes in Math., 1991, 1469: 127-137.[7]Dar, S., Remarks on Bourgain's problem on slicing of convex bodies, Geomitric aspects of functional analysis,in Oper. Theory Adv. Appl., Vol, 77, Basel: Birkhauser, 1995, 61-66.[8]Ball, K., Normed spaces with a weak-Gordon-Lewis property, in: Proc. of Funct. Anal., University of Texas and Austin (1987-1989), Lecture Notes in Math., 1991, 1470: 36-47.[9]Schneider, R., Weil, W., Zonoids and related topics, in Convexity and Its Applications (eds. Gruber, P. M., Wills,J. M.), Basel: Birkhauser, 1983, 296-317.[10]Bourgain, J., Klartag, B., Milman, V., A reduction of the slicing problem to finite volume ratio bodies, Geometry/Functional Analysis, C. R. Acad. Sci. Paris, Ser. I, 2003, 336: 331-334.[11]Ren, D. L., An Introduction to Integral Geometry (in Chinese), Shanghai: Science and Technology Press, 1988.[12]Gardner, R. J., Geometric Tomography, Cambridge: Cambridge University Press, 1995.[13]Leichtweiβ, K., Affine Geometry of Convex Bodies, Heidelberg: J. A. Barth, 1998.[14]Schneider, R., Convex Bodies: The Brunn

  7. Adenovirus-mediated transfer of p53 augments hyperthermia-induced apoptosis in U251 glioma cells

    International Nuclear Information System (INIS)

    Purpose: Hyperthermia kills glioma cells by inducing apoptosis and is thereby an effective therapeutic modality for the treatment of malignant gliomas. However, cells harboring mutated p53 are refractory to hyperthermia-induced apoptosis. In this study, we assessed whether or not adenovirus (Adv)-mediated transduction of p53 overrides this resistant mechanism. Methods and Materials: We transduced the p53 wild-type tumor suppressor gene into U251 glioma cells harboring mutated p53 using Adv vectors in combination with hyperthermia (43, 44.5 deg. C), and evaluated the degree of cell death and apoptosis. Results: The percentage of cells that had died, as measured by trypan blue staining, among U251 cells infected with the Adv for p53 (Adv-p53) and treated with hyperthermia, was significantly higher than the percentage of cells that had died among U251 cells infected with Adv-p53 and not treated with hyperthermia, or those infected with the control Adv for dE (Adv-dE) and treated with hyperthermia. The degree of apoptosis, measured at 24 h after treatment, in hyperthermia-treated U251 cells infected with Adv-p53 (43 deg. C, 73%; 44.5 deg. C, 92%) was much higher than that infected with Adv-p53 (41%), or that infected with control Adv-dE and treated with hyperthermia (43 deg. C, 1.3%; 44.5 deg. C, 19%). Treatment with combined hyperthermia and Adv-p53 infection induced cleavage of caspase-3 in U251 cells. Conclusion: These results indicate that Adv-mediated transduction of p53 would render glioma cells highly sensitive to hyperthermia

  8. Tracking adenovirus infections in reptiles

    OpenAIRE

    Ball, Inna

    2015-01-01

    The purpose of this project was to screen reptiles for the presence of adenovirus (AdV) infection, develop serological tests for the detection of antibodies against AdVs in squamate reptiles and to examine the serological relationships between lizard and snake AdVs, helping to ensure the establishment and maintenance of healthy populations. An additional aim of the project was the establishment of an agamid cell line and isolation of adenoviruses from bearded dragons (Pogona vitticeps). A...

  9. Rapid analysis of trace pollutants using laser mass spectrometry

    Institute of Scientific and Technical Information of China (English)

    WEI; Jie

    2001-01-01

    [1]Otsuka,K.,Kubo,H.,Wayman,C.M.,Diffuse electron scattering and “streaming” effect,Metall.Trans.A,1981,12:595-605.[2]Otsuka,K.,Wayman,C.M.,Kubo,H.,Diffuse electron scattering in β-phase alloys,Metall.Trans.A,1978,9:1075-1085.[3]Singh,J.,Chen,H.,Wayman,C.M.,Transformation sequence in a Cu-Al-Ni shape memory alloy at elevated temperatures,Metall.Trans.A,1986,17:65-72.[4]Sun,Y.S.,Lorimer,G.W.,Ridley,N.,Microstructure and its development in Cu-Al-Ni alloys,Metall.Trans.A,1990,21:575-588.[5]Miyazaki,S.,Kawai,T.,Otsuka,K.,On the origin of intergranular fracture in β phase shape memory alloys,Scripta Metall.,1982,16:431-436.[6]Otsuka,K.,Wayman,C.M.,Naka,K.et al.,Superelasticity effects and stress-induced martensitic transformations in Cu-Al-Ni alloys,Acta Metall.,1976,24:207-226.[7]Otsuka,K.,Sakamoto,H.,Shimizu,K.,Successive stress-induced martensitic transformations and associated transformation pseudoelasticity in Cu-Al-Ni alloys,Acta Metall.,1979,27:585-600.[8]Shield,T.W.,Orientation dependence of the pseudoelastic behavior of single crystal of Cu-Al-Ni in tension,J.Mech.Phys.Solids,1995,43(6):869-895.[9]Sun,Q.P.,Zhang,X.Y.,Xu,T.,Experimental study of martensitic transformation in single shape memory alloy,Adv.Solids Mech.,1997,7:155-162.[10]Chen,Q.Z.,Chu,W.Y.,Hsiao,C.M.,In-situ TEM observation of nucleation and bluntness of nanocrack in 310 stainless steel,Acta Metall.Mater.,1995,43:4371-4376.[11]Chu,W.Y.,Gao,K.W.,Wang,Y.B.et al.,Nucleating and propagation of nanocrack in dislocation free zone in brittle material,Science in China,Ser.A,1995,38(14):1501-1509.[12]Chen,Q.Z.,Gao,K.W.,Gu,B.et al.,Nucleating,blunting and propagation of A nanocrack in DFZ of thin crystals,Fatigue Frac.Eng.Mater.Stru.,1996,21:1415-1423.[13]Nishiyama,Z.,Stacking faults in the martensite of Cu-Al alloy,Journal of the Physical Society of Japan,1965,20:1192-1121.[14]Lovey,F.C.,Van Tendeloo,G.,Van Landuyt,J.et al.,HREM imaging

  10. Highly-efficient all-dielectric Huygens' surface holograms (Conference Presentation)

    Science.gov (United States)

    Chong, Katie; Wang, Lei; Staude, Isabelle; James, Anthony; Dominguez, Jason; Subramania, Ganapathi; Liu, Sheng; Decker, Manuel; Neshev, Dragomir N.; Brener, Igal; Kivshar, Yuri S.

    2016-04-01

    that lack dissipative losses and also suppress unwanted reflections without relying on cross-polarization schemes that additionally suffer from polarization-conversion losses. We now use such Huygens' surfaces in order to create a highly-efficient phase masks for the generation of optical holograms. By varying only one geometrical parameter, namely the lattice periodicity that can be controlled easily during the fabrication process we can effectively generate arbitrary hologram images from a 4-level phase discretization. In order to design the arrangement of the pixels in the metasurfaces, we calculate the phase mask required for a hologram generating the letters `hv' in the hologram plane. In the next step the Huygens' hologram is fabricated on a back-side polished SOI wafer by electron-beam lithography followed by a reactive-ion etching process. Then, we measure the phase of the generated hologram using a home-built Mach-Zehnder interferometer and perform a phase retrieval process to compare the experimental phase with the designed phase. Finally, we record the holographic image in the hologram plane and demonstrate that the device functionality is completely polarization insensitive with a transmission efficiency of 82%, in contrast to all the earlier works utilizing geometric phase. References [1] Yu et al., Nat. Mater. 13, 139 (2014). [2] Pfeiffer et al., Phys. Rev. Lett. 110, 197401 (2013). [3] Monticone et al., Phys. Rev. Lett. 110, 203903 (2013). [4] Decker et al., Adv. Opt. Mater. 3, 813 (2015).

  11. Characterizing filamentary switching in resistive memories (Presentation Recording)

    Science.gov (United States)

    Busby, Yan; Pireaux, Jean-Jacques

    2015-09-01

    .J.W. List-Kratochvil, Adv. Mater. 2014, 26, 2508-2513. [2] Y. Busby, N. Crespo-Monteiro, M. Girleanu, M. Brinkmann, O. Ersen, J.-J. Pireaux, Organic Electronics 2015, 16, 40-45. [3] C. Wolf, S. Nau, S. Sax, Y. Busby, J.-J. Pireaux, E.J.W. List-Kratochvil (under submission). [4] G. Casula, P. Cosseddu, Y. Busby, J.-J. Pireaux, M. Rosowski, B. Tkacz Szczesna, K. Soliwoda, G. Celichowski, J. Grobelny, J. Novák, R. Banerjee, F. Schreiber, A. Bonfiglio, Organic Electronics, 2015, 18, 17-23. [5] Y. Busby, S. Nau, S. Sax, E.J.W. List- Kratochvil, J. Novak, R. Banerjee, F. Schreiber, J.-J. Pireaux, (under submission)

  12. Foreword: Focus on Superconductivity in Semiconductors

    Directory of Open Access Journals (Sweden)

    Yoshihiko Takano

    2008-01-01

    Full Text Available Since the discovery of superconductivity in diamond, much attention has been given to the issue of superconductivity in semiconductors. Because diamond has a large band gap of 5.5 eV, it is called a wide-gap semiconductor. Upon heavy boron doping over 3×1020 cm−3, diamond becomes metallic and demonstrates superconductivity at temperatures below 11.4 K. This discovery implies that a semiconductor can become a superconductor upon carrier doping. Recently, superconductivity was also discovered in boron-doped silicon and SiC semiconductors. The number of superconducting semiconductors has increased. In 2008 an Fe-based superconductor was discovered in a research project on carrier doping in a LaCuSeO wide-gap semiconductor. This discovery enhanced research activities in the field of superconductivity, where many scientists place particular importance on superconductivity in semiconductors.This focus issue features a variety of topics on superconductivity in semiconductors selected from the 2nd International Workshop on Superconductivity in Diamond and Related Materials (IWSDRM2008, which was held at the National Institute for Materials Science (NIMS, Tsukuba, Japan in July 2008. The 1st workshop was held in 2005 and was published as a special issue in Science and Technology of Advanced Materials (STAM in 2006 (Takano 2006 Sci. Technol. Adv. Mater. 7 S1.The selection of papers describe many important experimental and theoretical studies on superconductivity in semiconductors. Topics on boron-doped diamond include isotope effects (Ekimov et al and the detailed structure of boron sites, and the relation between superconductivity and disorder induced by boron doping. Regarding other semiconductors, the superconducting properties of silicon and SiC (Kriener et al, Muranaka et al and Yanase et al are discussed, and In2O3 (Makise et al is presented as a new superconducting semiconductor. Iron-based superconductors are presented as a new series of high

  13. Thermodynamic Property Models for Unburned Mixtures and Combustion Gases

    OpenAIRE

    Messina Michele; Lanzafame Rosario

    2006-01-01

    New mathematical functions, with the functional form of a fifth order logarithmic polynomial, have been developed. These polynomials have been used to describe gases’ thermodynamic properties, and have been utilized for combustion processes, with “frozen composition” and “shifting equilibrium composition” evaluation. The logarithmic polynomials present the advantage of covering a wide range of temperatures with only a single mathematical funct...

  14. Strichartz Estimates for the Schrödinger Propagator for the Laguerre Operator

    Indian Academy of Sciences (India)

    Vijay Kumar Sohani

    2013-11-01

    We obtain homogeneous Strichartz estimate for the Schrödinger propagator $e^{-itL_}$ for the Laguerre operator $L_$ on $\\mathbb{R}^n_+$. We follow regularization technique as introduced in J. Funct. Anal. 224(2) (2005) 371–385. We also establish inhomogeneous Strichartz estimates for different admissible pairs.

  15. Medication adherence in patients with rheumatoid arthritis: a critical appraisal of the existing literature

    NARCIS (Netherlands)

    Bemt, B.J.F. van den; Zwikker, H.E.; Ende, C.H.M. van den

    2012-01-01

    Adherence to medication in patients with rheumatoid arthritis is low, varying from 30 to 80%. Improving adherence to therapy could therefore dramatically improve the efficacy of drug therapy. Although indicators for suboptimal adherence can be useful to identify nonadherent patients, and could funct

  16. Applying footprint models to investigate MO-dissimilarity over heterogeneous areas

    NARCIS (Netherlands)

    Boer, van de A.; Graf, A.; Moene, A.F.; Schüttemeyer, D.

    2012-01-01

    Monin Obukhov Similarity Theory (MOST) is one of the cornerstones of surface layer meteorology and as such it is widely applied in models and for data analysis. One major disadvantage of using MOST for describing land-atmosphere interactions is that all turbulence properties are described as a funct

  17. Sequence Classification: 525247 [

    Lifescience Database Archive (English)

    Full Text Available ion unknown, intitally thought to be hydrogenase-2 small subunit which now identified as hybO || http://www.ncbi.nlm.nih.gov/protein/62181660 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|62181660|ref|YP_218077.1| funct

  18. Velocity profiles in strongly turbulent Taylor-Couette flow

    NARCIS (Netherlands)

    Grossmann, S.; Lohse, D.; Sun, C.

    2014-01-01

    We derive the velocity profiles in strongly turbulent Taylor-Couette flow for the general case of independently rotating cylinders. The theory is based on the Navier-Stokes equations in the appropriate (cylinder) geometry. In particular, we derive the axial and the angular velocity profiles as funct

  19. Exponential decay rate of the power spectrum for solutions of the Navier--Stokes equations

    International Nuclear Information System (INIS)

    Using a method developed by Foias and Temam [J. Funct. Anal. 87, 359 (1989)], exponential decay of the spatial Fourier power spectrum for solutions of the incompressible Navier--Stokes equations is established and explicit rigorous lower bounds on a small length scale defined by the exponential decay rate are obtained

  20. Neuronal stress following exposure to 56Fe particles and the effects of antioxidant-rich diets

    Science.gov (United States)

    Exposing young rats to particles of high energy and charge (HZE particles), a ground-based model for exposure to cosmic rays, enhances indices of oxidative stress and inflammation and disrupts the functioning of neuronal communication in critical regions of the brain. These changes in neuronal funct...

  1. Ecological, Social and Economic Evaluation of Transport Scenarios: An Integral Approach. A Phd research programme

    NARCIS (Netherlands)

    Geurs KT; LAE

    2000-01-01

    This report describes a research programme for the development of a methodology for the integral assessment of ecological, economic and social impacts of transport scenarios. The following research activities are planned: (1) a literature study on theories and conceptual models, explaining the funct

  2. Safety and clinical outcome of erythropoiesis-stimulating agents in patients with ST-elevation myocardial infarction : A meta-analysis of individual patient data

    NARCIS (Netherlands)

    Fokkema, Marieke L.; van der Meer, Peter; Rao, Sunil V.; Belonje, Anne M.; Ferrario, Maurizio; Hillege, Hans L.; Katz, Stuart D.; Lipsic, Erik; Ludman, Andrew J.; Ott, Ilka; Prunier, Fabrice; Choi, Dong-Ju; Toba, Ken; van Veldhuisen, Dirk J.; Voors, Adriaan A.

    2014-01-01

    Background Erythropoiesis-stimulating agents (ESAs) have been investigated in small studies in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Erythropoiesis-stimulating agents did not show a clear effect on left ventricular funct

  3. Origin, Impact and Cost of Interface Instability

    NARCIS (Netherlands)

    Raemaekers, S.B.A.

    2015-01-01

    Third-party libraries are used frequently in modern software development. Websites that are visited millions of times a day often make heavy use of open-source software libraries. As a software developer, using these libraries has a number of advantages. Developers save time and effort because funct

  4. Vibration sense and sympathetic vasoconstrictor activity in patients with occlusive arterial disease

    DEFF Research Database (Denmark)

    Bjerre-Jepsen, K; Henriksen, O; Parm, Martin Lehnsbo; Agerskov, K; Tønnesen, K H

    1983-01-01

    The function of sympathetic vasoconstrictor fibres was studied in 18 patients with occlusive arterial disease of the legs and somatic neuropathy, as evidenced as an increased vibration perception threshold. Nine patients suffered from long-term diabetes mellitus. Sympathetic vasoconstrictor funct...

  5. SABATH Methyltransferases from White Spruce (Picea glauca [Moench] Voss): Gene Cloning, Functional Characterization and Structural Analysis

    Science.gov (United States)

    Known members of the plant SABATH family of methyltransferases have important biological functions by methylating hormones, signaling molecules and other metabolites. While all previously characterized SABATH genes were isolated from angiosperms, in this article, we report on the isolation and funct...

  6. What is a Sorting Function?

    DEFF Research Database (Denmark)

    Henglein, Fritz

    2009-01-01

    What is a sorting function—not a sorting function for a given ordering relation, but a sorting function with nothing given? Formulating four basic properties of sorting algorithms as defining requirements, we arrive at intrinsic notions of sorting and stable sorting: A function is a sorting funct...

  7. Drawbacks of the use of indirect estimates of renal function to evaluate the effect of risk factors on renal function

    NARCIS (Netherlands)

    Verhave, JC; Gansevoort, RT; Hillege, HL; De Zeeuw, D; Curhan, GC; De Jong, PE

    2004-01-01

    Many epidemiologic studies presently aim to evaluate the effect of risk factors on renal function. As direct measurement of renal function is cumbersome to perform, epidentiologic studies generally use an indirect estimate of renal function. The consequences of using different methods of renal funct

  8. Main: 1N8Q [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available Protocatechuic Acid In Its X-Ray Structure At 2.1 A Resolution. Proteins: V. 54 13 2004 Struct., Funct., Ge..._1; 1.|PROSITE; PS00081; LIPOXYGENASE_2; 1.|PROSITE; PS50095; PLAT; 1. X-Ray Diffraction, Resolution: 2.10 A

  9. Unilateral Tinnitus : Changes in Connectivity and Response Lateralization Measured with fMRI

    NARCIS (Netherlands)

    Lanting, Cornelis P.; de Kleine, Emile; Langers, Dave R. M.; van Dijk, Pim

    2014-01-01

    Tinnitus is a percept of sound that is not related to an acoustic source outside the body. For many forms of tinnitus, mechanisms in the central nervous system are believed to play a role in the pathology. In this work we specifically assessed possible neural correlates of unilateral tinnitus. Funct

  10. Immune evasion by pseudomonal proteases

    NARCIS (Netherlands)

    Bardoel, B.W.

    2011-01-01

    The innate immune system recognizes and rapidly kills invading bacteria via different mechanisms. Bacteria exploit several strategies to evade recognition by the immune system in order to survive within the host. An important strategy of bacteria is the secretion of proteins that block crucial funct

  11. Severe degeneration of peripheral motor axons after spinal cord injury: a European multicenter study in 345 patients.

    NARCIS (Netherlands)

    Meent, H. van de; Hosman, A.J.F.; Hendriks, J.; Zwarts, M.J.; Schubert, M.

    2010-01-01

    OBJECTIVE: There are indications that perilesional and remote peripheral motor axons may degenerate after spinal cord injury (SCI). The authors investigated the magnitude and dependence on severity of SCI of this degeneration as well as whether motor axons so affected can recover. METHODS: The funct

  12. Interdisciplinary Evaluation of Broadly-Reactive HLA Class II Restricted Epitopes Eliciting HIV-Specific CD4+T Cell Responses

    DEFF Research Database (Denmark)

    Buggert, M.; Norström, M.; Lundegaard, Claus; Lund, Ole; Nielsen, Morten; Karlsson, A. C.

    2011-01-01

    Background: CD4+ T cells orchestrate immune protection by ‘‘helping’’ other cells of our immune system to clear viral infections. It is well known that the preferential infection and depletion of CD4+ T cells contributes to hampered systemic T cell help following HIV infection. However, the funct...

  13. D1-protein dynamics in photosystem II: the lingering enigma

    Science.gov (United States)

    The D1/D2 heterodimer core dominates the photosystem II reaction center. A characteristic feature of this heterodimer is the differentially rapid, light-dependent degradation of the D1 protein. The D1 protein is possibly the most researched photosynthetic polypeptide, with aspects of structure–funct...

  14. Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition

    NARCIS (Netherlands)

    Jansen, Sepp R; Poppinga, Wilfred J; de Jager, Wim; Lezoualc'h, Frank; Cheng, Xiaodong; Wieland, Thomas; Yarwood, Stephen J; Gosens, Reinoud; Schmidt, Martina

    2016-01-01

    In epithelial cells, β-catenin is localized at cell-cell junctions where it stabilizes adherens junctions. When these junctions are disrupted, β-catenin can translocate to the nucleus where it functions as a transcriptional cofactor. Recent research has indicated that PGE2 enhances the nuclear funct

  15. Fluorescence relaxation spectroscopy: light on dynamical structures of flavoproteins.

    NARCIS (Netherlands)

    Burten-Bastiaens, P.I.H.

    1992-01-01

    Refinements in technique and data analysis have opened new avenues for a detailed interpretation of protein fluorescence. What is more, by combining new insights in protein structure and dynamics with improved knowledge of photophysics of biological chromophores, the coupling between structure-funct

  16. Cardiovascular risk prediction in the Netherlands

    NARCIS (Netherlands)

    Dis, van S.J.

    2011-01-01

    Background: In clinical practice, Systematic COronary Risk Evaluation (SCORE) risk prediction functions and charts are used to identify persons at high risk for cardiovascular diseases (CVD), who are considered eligible for drug treatment of elevated blood pressure and serum cholesterol. These funct

  17. Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor

    NARCIS (Netherlands)

    Alam, Mohammad Tauqeer; Takano, Eriko; Breitling, Rainer

    2011-01-01

    Background: Streptomyces coelicolor, a model organism of antibiotic producing bacteria, has one of the largest genomes of the bacterial kingdom, including 7825 predicted protein coding genes. A large number of these genes, nearly 34%, are functionally orphan (hypothetical proteins with unknown funct

  18. IMPACT OF VITAMIN E ON IMMUNE FUNCTION AND ITS CLINICAL IMPLICATIONS

    Science.gov (United States)

    Vitamin E is a chain-braking antioxidant that protects membranes from free radical damage. Evidence suggests significant impact of vitamin E on modulation of immune functions. Results from animal and human studies indicate that vitamin E deficiency impairs both humoral and cell-mediated immune funct...

  19. Main: 1LNH [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available 1LNH 大豆 Soybean Glycine max (L.) Merrill Seed Lipoxygenase-3 Name=Lox1.3; Synonyms=Lox3; Glyci ... Junior Structure Of Soybean Lipoxygenase L3 And A Comparison ... With Its L1 Isoenzyme Proteins: Struct., Funct., V ...

  20. Bargaining for Over-The Counter Risk Redistributions : The Case of Longevity Risk

    NARCIS (Netherlands)

    Boonen, T.J.; De Waegenaere, A.M.B.; Norde, H.W.

    2012-01-01

    Abstract: Existing literature regarding the natural hedge potential that arises from combining liabilities with different sensitivities focuses on the optimal liability mix, but does not address the question whether and how changes in the liability mix can be obtained. In the absence of a well-funct

  1. Human hand modelling: kinematics, dynamics, applications

    NARCIS (Netherlands)

    Gustus, A.; Stillfried, G.; Visser, J.; Jörntell, H.; Van der Smagt, P.

    2012-01-01

    An overview of mathematical modelling of the human hand is given. We consider hand models from a specific background: rather than studying hands for surgical or similar goals, we target at providing a set of tools with which human grasping and manipulation capabilities can be studied, and hand funct

  2. The Relationship Between the Positivity of Parvovirus B19-DNA and the Level of Soluble Interleukin-2 Receptors of Infected Maters%孕妇细小病毒B19-DNA阳性与血清可溶性白介素-2受体水平的关系

    Institute of Scientific and Technical Information of China (English)

    曹懿; 屈新中; 李芬

    2006-01-01

    目的:通过研究细小病毒B19(parvovirus B19,B19)感染孕妇的妊娠结局与血清可溶性白介素-2受体(sIL-2R)的关系,探讨体内的细胞免疫状态对妊娠结局的作用.方法:随访14例B19-DNA阳性孕妇的妊娠结局并检测新生儿脐血血清中的B19-DNA,比较不同妊娠结局孕妇、新生儿脐血血清中的sIL-2R.结果:①B19-DNA阳性孕妇分娩的14例新生儿中,B19-DNA阳性4例,阴性10例,宫内传播率为28.57%;②B19-DNA阳性的新生儿组血清sIL-2R为(642.32±64.51)pg/l,明显高于阴性组(379.96±56.47)pg/ml(p<0.05);③新生儿脐血B19-DNA阳性的孕妇组血清sIL-2R为(569.48±162.66)pg/ml明显高于新生儿阴性的孕妇组(363.12±86.62)pg/ml(p<0.05).结论:B19感染孕妇血清sIL-2R升高对胎儿宫内感染有一定的提示作用.B19感染孕妇体内的细胞免疫增强,不利于孕期的细胞/体液免疫平衡,可能是导致不良妊娠结局产生的原因之一.

  3. Agregační účinnost fliudní vrstvy zrnitého materálu při úpravě povrchových vod se zvýšenou koncentrací DOC a nízkou alkalitou

    Czech Academy of Sciences Publication Activity Database

    Pivokonský, Martin; Pivokonská, Lenka

    Bratislava : Ministerstvo životného prostredia SR, 2007, s. 285-292. [Pitná voda. Trenčianské Teplice (SK), 09.10.2007-11.10.2007] R&D Projects: GA ČR GA103/07/1016 Institutional research plan: CEZ:AV0Z20600510 Keywords : aggregation * destabilization * filtration * velocity gradient * separation efficiency Subject RIV: DJ - Water Pollution ; Quality

  4. Degradação da matéria seca e da proteína bruta de silagens de milho sem espigas com cana -de-açúcar e bagaço de mandioca = Dry mater and crude protein ruminal degradation of corn silage without spikes with sugar cane and manioc pulp

    OpenAIRE

    Marcos Elias Traad da Silva; Nina Waszczynskyj; Carlos Ricardo Soccol; Paulo Rossi Junior; Leandro Cavalcante Lipinski

    2006-01-01

    A degradação ruminal da matéria seca (MS) e da proteína bruta (PB) de silagen s de milho sem espigas (SMSE) com cana -de-açúcar (CA) e bagaço seco de mandioca (BSM), comparadas com a silagem de milho com espigas (SMCE), foi avaliada. A ensilagem foi feita com (CI) e sem inoculante (SI) - Lactobacillus plantarum e L paracasei ssp. paracasei. Estudaram-se: as frações solúvel (A), potencialmente degradável (B) e não degradável (C); a taxa de degradação da fração B (c); a degradabilidade efetiva ...

  5. Degradabilidade in situ da silagem de quatro genótipos de sorgo com e sem tanino: I - Matéria seca e proteína bruta In situ degradability of four sorgum silages with or without tannin: I - Dry mater and crude protein

    Directory of Open Access Journals (Sweden)

    W.E. Campos

    2003-04-01

    Full Text Available Avaliaram-se a degradabilidade in situ da matéria seca (MS e da proteína bruta (PB da silagem de quatro genótipos de sorgo, dois com tanino (CMS XS 210 e BR 701 e dois sem tanino (CMS XS 214 e BR007 em um delineamento de blocos inteiramente ao acaso, com três repetições (animais, em arranjo de parcelas subdivididas. Os genótipos constituíram as parcelas e os tempos de digestão as subparcelas. O genótipo CMS XS 210 apresentou menor degradabilidade da MS em relação aos demais e os genótipos que continham tanino (CMS XS 210 e BR 701 apresentaram menores degradabilidades da PB em relação aos que não o continham.The in situ procedure was used to evaluate the disappearance of dry matter (DM and crude protein (CP of four sorghum genotypes with (CMS XS 210 and BR 701 or without (CMS XS 214 and BR 007 tannin in a completely randomized block design experiment with three replicates (animals, in a split plot arrangement. The four genotypes were allotted to the plots and the time of disappearance to the split plot. The DM of CMS XS210 was less degraded when compared to the others and sorghums with tannin showed lower CP degradability when compared to the sorghums without tannin.

  6. Degradação da matéria seca e da proteína bruta de silagens de milho sem espigas com cana -de-açúcar e bagaço de mandioca = Dry mater and crude protein ruminal degradation of corn silage without spikes with sugar cane and manioc pulp

    Directory of Open Access Journals (Sweden)

    Marcos Elias Traad da Silva

    2006-10-01

    Full Text Available A degradação ruminal da matéria seca (MS e da proteína bruta (PB de silagen s de milho sem espigas (SMSE com cana -de-açúcar (CA e bagaço seco de mandioca (BSM, comparadas com a silagem de milho com espigas (SMCE, foi avaliada. A ensilagem foi feita com (CI e sem inoculante (SI - Lactobacillus plantarum e L paracasei ssp. paracasei. Estudaram-se: as frações solúvel (A, potencialmente degradável (B e não degradável (C; a taxa de degradação da fração B (c; a degradabilidade efetiva (DE e potencial (DP, para ostratamentos: T1 (SMSE+20% CA -SI; T2 (SMSE+20% CA -CI; T3 (SMSE+35% CASI; T4 (SMSE+35% CA-CI; T5 (SMSE+20% BSM-SI; T6 (SMSE+20% BSM-CI; T7 (SMSE+35% BSM-SI; T8 (SMSE+35% BSM-CI; T9 (SMCE-SI e T10 (SMCE-CI. As médias foram comparadas num delineamento inteiramente casualisado. Houve diferença (P0,05. A adição de BSM (20 e 35% às SMSE aumentou (PThe goal of this work was to evaluate the ruminal degradation of corn silages without spikes (CSWS, added with sugar cane (SC and dry manioc pulp (DMP, as compared as corn silage (CS. The foods were ensiled with (WI and without (IF inoculant’s, composed by Lactobacillus plantarum and L. paracasei ssp. paracasei. The following fractions have been studied: water soluble (A, potentiallydegradable (B, non degradable (C, fraction B degradable ratio (c; effective (ED and potential (PD degradability. The treatments evaluated were: T1 (CSWS + 20% SC -IF; T2 (CSWS + 20% SC-WI; T3 (CSWS + 35% SC -IF; T4 (CSWS + 35% SC -WI; T5 (CSWS + 20% DMP-IF; T6 (CSWS + 20% DMP -WI; T7 (CSWS + 35% DMP -IF; T8 (CSWS + 35% DMP-WI; T9 (CS-WI and T10 (CS-IF. The average differences havebeen compared on a completely randomized model. Difference (P 0.05 for all treatments. Dry manioc pulp added to the non spikes cornsilage (20 and 35% - DM basis, has allowed the rise of the DM fraction B, indicating the possibility to add up to 35% of dry manioc pulp on corn silage, inst ead of green spikes.

  7. Consumo, produção de leite e estresse térmico em vacas da raça Pardo-Suíça alimentadas com castanha de caju Dry mater intake, milk yield, and heat stress indicators of dairy cows fed diets with cashew nut

    OpenAIRE

    P.G. Pimentel; A.A.A.N. Moura; J.N.M Neiva; Araújo, A. A.; R.F.L. Tair

    2007-01-01

    Avaliaram-se o consumo de matéria seca, a produção de leite e os indicadores de estresse térmico de vacas Pardo-Suíça alimentadas com castanha de caju no semi-árido do Nordeste do Brasil. Doze animais foram distribuídos em um ensaio de reversão, com quatro tratamentos: 0, 8, 16 e 24% de castanha no concentrado. As vacas receberam cana-de-açúcar à vontade e sete quilos de concentrado por dia. Maior consumo de matéria seca de cana-de-açúcar foi observado no tratamento com concentrado sem castan...

  8. Degradabilidade in situ da silagem de quatro genótipos de sorgo com e sem tanino: I - Matéria seca e proteína bruta In situ degradability of four sorgum silages with or without tannin: I - Dry mater and crude protein

    OpenAIRE

    W.E. Campos; H.M. Saturnino; B.M. Sousa; I. Borges; L.C. Gonçalves; Ferreira, P. M.; A.U. Carvalho

    2003-01-01

    Avaliaram-se a degradabilidade in situ da matéria seca (MS) e da proteína bruta (PB) da silagem de quatro genótipos de sorgo, dois com tanino (CMS XS 210 e BR 701) e dois sem tanino (CMS XS 214 e BR007) em um delineamento de blocos inteiramente ao acaso, com três repetições (animais), em arranjo de parcelas subdivididas. Os genótipos constituíram as parcelas e os tempos de digestão as subparcelas. O genótipo CMS XS 210 apresentou menor degradabilidade da MS em relação aos demais e os genótipo...

  9. Consumo, produção de leite e estresse térmico em vacas da raça Pardo-Suíça alimentadas com castanha de caju Dry mater intake, milk yield, and heat stress indicators of dairy cows fed diets with cashew nut

    Directory of Open Access Journals (Sweden)

    P.G. Pimentel

    2007-12-01

    Full Text Available Avaliaram-se o consumo de matéria seca, a produção de leite e os indicadores de estresse térmico de vacas Pardo-Suíça alimentadas com castanha de caju no semi-árido do Nordeste do Brasil. Doze animais foram distribuídos em um ensaio de reversão, com quatro tratamentos: 0, 8, 16 e 24% de castanha no concentrado. As vacas receberam cana-de-açúcar à vontade e sete quilos de concentrado por dia. Maior consumo de matéria seca de cana-de-açúcar foi observado no tratamento com concentrado sem castanha (7,70kgMS/dia em relação aos tratamentos com 16% e 24% de castanha (7,35 e 7,05kgMS/dia, respectivamente. O consumo no tratamento com concentrado sem castanha não diferiu do consumo no tratamento com 8% (7,59kgMS/dia. Não houve efeito dos tratamentos sobre a produção de leite e sobre as variáveis indicativas de estresse térmico (P>0,05.A study was carried out to evaluate dry matter intake, milk yield, and heat stress parameters in Brown Swiss cows fed diets with cashew nut. Animals were raised in the semi-arid region of the Brazilian Northeast. Twelve cows were subjected to a switch back experimental design, with four treatments: 0, 8, 16, and 24% of cashew nut in the concentrate. Each cow received 7kg of concentrate per day and had free access to sugar cane. Dry matter (DM intake and milk yield were daily taken as well as measurements of rectal and milk temperature; and cardiac and respiratory rates. The highest intake of forage (sugar cane was obtained when the concentrate had no cashew nut (7.7kgDM/day. This value was not different when the concentrate contained 8% of cashew nut (7.59kgDM/day but greater than dry matter intake of cows receiving diets with 16% of cashew nut (7.35kgDM/day; P0.05. Such low variability in daily milk yield could be associated with the higher energy density of diets containing more cashew nut. Finally, indicators of heat stress were not influenced by changes in the diets, given the air temperatures and environment where all cows were raised.

  10. Investigations on fungal parasites of marine algae in India: An appraisal

    Digital Repository Service at National Institute of Oceanography (India)

    Raghukumar, C.; Raghukumar, S.

    stream_size 12 stream_content_type text/plain stream_name Recent_Adv_Phycol_1994_39.pdf.txt stream_source_info Recent_Adv_Phycol_1994_39.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  11. Effects of Levels of Automation for Advanced Small Modular Reactors: Impacts on Performance, Workload, and Situation Awareness

    Energy Technology Data Exchange (ETDEWEB)

    Johanna Oxstrand; Katya Le Blanc

    2014-07-01

    The Human-Automation Collaboration (HAC) research effort is a part of the Department of Energy (DOE) sponsored Advanced Small Modular Reactor (AdvSMR) program conducted at Idaho National Laboratory (INL). The DOE AdvSMR program focuses on plant design and management, reduction of capital costs as well as plant operations and maintenance costs (O&M), and factory production costs benefits.

  12. Marine archaeological surveys off Tranquebar Tamilnadu coast - preliminary results

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, T.C.S.; Rao, K.M.

    stream_size 3 stream_content_type text/plain stream_name Recent_Adv_Mar_Archaeol_1991_127.pdf.txt stream_source_info Recent_Adv_Mar_Archaeol_1991_127.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  13. Consequences of sea level rise due to greenhouse effect for coastal archaeological monuments

    Digital Repository Service at National Institute of Oceanography (India)

    Nigam, R.; Pathak, M.C.; Hashimi, N.H.

    stream_size 6 stream_content_type text/plain stream_name Recent_Adv_Mar_Archaeol_1991_116.pdf.txt stream_source_info Recent_Adv_Mar_Archaeol_1991_116.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  14. Relevance of topography and sediment in ship wreck exploration - Examples from Goa waters

    Digital Repository Service at National Institute of Oceanography (India)

    Pathak, M.C.; Hashimi, N.H.; Nigam, R.

    stream_size 6 stream_content_type text/plain stream_name Recent_Adv_Mar_Archaeol_1991_135.pdf.txt stream_source_info Recent_Adv_Mar_Archaeol_1991_135.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  15. Complete genome sequence and integrated protein localization and interaction map for alfalfa dwarf virus, which combines properties of both cytoplasmic and nuclear plant rhabdoviruses

    Energy Technology Data Exchange (ETDEWEB)

    Bejerman, Nicolás, E-mail: n.bejerman@uq.edu.au [Instituto de Patología Vegetal (IPAVE), Centro de Investigaciones Agropecuarias (CIAP), Instituto Nacional de Tecnología Agropecuaria INTA, Camino a 60 Cuadras k 5,5, Córdoba X5020ICA (Argentina); Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, QLD 4072 (Australia); Giolitti, Fabián; Breuil, Soledad de; Trucco, Verónica; Nome, Claudia; Lenardon, Sergio [Instituto de Patología Vegetal (IPAVE), Centro de Investigaciones Agropecuarias (CIAP), Instituto Nacional de Tecnología Agropecuaria INTA, Camino a 60 Cuadras k 5,5, Córdoba X5020ICA (Argentina); Dietzgen, Ralf G. [Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, QLD 4072 (Australia)

    2015-09-15

    Summary: We have determined the full-length 14,491-nucleotide genome sequence of a new plant rhabdovirus, alfalfa dwarf virus (ADV). Seven open reading frames (ORFs) were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, in the order 3′-N-P-P3-M-G-P6-L-5′. The ORFs are separated by conserved intergenic regions and the genome coding region is flanked by complementary 3′ leader and 5′ trailer sequences. Phylogenetic analysis of the nucleoprotein amino acid sequence indicated that this alfalfa-infecting rhabdovirus is related to viruses in the genus Cytorhabdovirus. When transiently expressed as GFP fusions in Nicotiana benthamiana leaves, most ADV proteins accumulated in the cell periphery, but unexpectedly P protein was localized exclusively in the nucleus. ADV P protein was shown to have a homotypic, and heterotypic nuclear interactions with N, P3 and M proteins by bimolecular fluorescence complementation. ADV appears unique in that it combines properties of both cytoplasmic and nuclear plant rhabdoviruses. - Highlights: • The complete genome of alfalfa dwarf virus is obtained. • An integrated localization and interaction map for ADV is determined. • ADV has a genome sequence similarity and evolutionary links with cytorhabdoviruses. • ADV protein localization and interaction data show an association with the nucleus. • ADV combines properties of both cytoplasmic and nuclear plant rhabdoviruses.

  16. Molecular characterization, phylogeny analysis and pathogenicity of a Muscovy duck adenovirus strain isolated in China in 2014

    Science.gov (United States)

    This study aimed to characterize a novel adenovirus (AdV) isolated from diseased Muscovy ducks in China. After the AdV was successfully propagated in duck embryo fibroblasts, the morphological and physicochemical properties of the virions were studied by electron microscopy and different tests. The ...

  17. Topography and surface sediment distribution around Amee shoal Mormugao

    Digital Repository Service at National Institute of Oceanography (India)

    Ambre, N.V.

    stream_size 3 stream_content_type text/plain stream_name Recent_Adv_Mar_Archaeol_1991_113.pdf.txt stream_source_info Recent_Adv_Mar_Archaeol_1991_113.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  18. The impact of developmental activities on the coastal environment and ecology in Goa - Case study

    Digital Repository Service at National Institute of Oceanography (India)

    Sawkar, K.

    stream_size 11 stream_content_type text/plain stream_name Adv_Int_Trg_Prog_CMEPP-98_1998_10pp.pdf.txt stream_source_info Adv_Int_Trg_Prog_CMEPP-98_1998_10pp.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO...

  19. A novel adenovirus of Western lowland gorillas (Gorilla gorilla gorilla

    Directory of Open Access Journals (Sweden)

    Ludwig Carsten

    2010-11-01

    Full Text Available Abstract Adenoviruses (AdV broadly infect vertebrate hosts including a variety of primates. We identified a novel AdV in the feces of captive gorillas by isolation in cell culture, electron microscopy and PCR. From the supernatants of infected cultures we amplified DNA polymerase (DPOL, preterminal protein (pTP and hexon gene sequences with generic pan primate AdV PCR assays. The sequences in-between were amplified by long-distance PCRs of 2 - 10 kb length, resulting in a final sequence of 15.6 kb. Phylogenetic analysis placed the novel gorilla AdV into a cluster of primate AdVs belonging to the species Human adenovirus B (HAdV-B. Depending on the analyzed gene, its position within the cluster was variable. To further elucidate its origin, feces samples of wild gorillas were analyzed. AdV hexon sequences were detected which are indicative for three distinct and novel gorilla HAdV-B viruses, among them a virus nearly identical to the novel AdV isolated from captive gorillas. This shows that the discovered virus is a member of a group of HAdV-B viruses that naturally infect gorillas. The mixed phylogenetic clusters of gorilla, chimpanzee, bonobo and human AdVs within the HAdV-B species indicate that host switches may have been a component of the evolution of human and non-human primate HAdV-B viruses.

  20. Complete genome sequence and integrated protein localization and interaction map for alfalfa dwarf virus, which combines properties of both cytoplasmic and nuclear plant rhabdoviruses

    International Nuclear Information System (INIS)

    Summary: We have determined the full-length 14,491-nucleotide genome sequence of a new plant rhabdovirus, alfalfa dwarf virus (ADV). Seven open reading frames (ORFs) were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, in the order 3′-N-P-P3-M-G-P6-L-5′. The ORFs are separated by conserved intergenic regions and the genome coding region is flanked by complementary 3′ leader and 5′ trailer sequences. Phylogenetic analysis of the nucleoprotein amino acid sequence indicated that this alfalfa-infecting rhabdovirus is related to viruses in the genus Cytorhabdovirus. When transiently expressed as GFP fusions in Nicotiana benthamiana leaves, most ADV proteins accumulated in the cell periphery, but unexpectedly P protein was localized exclusively in the nucleus. ADV P protein was shown to have a homotypic, and heterotypic nuclear interactions with N, P3 and M proteins by bimolecular fluorescence complementation. ADV appears unique in that it combines properties of both cytoplasmic and nuclear plant rhabdoviruses. - Highlights: • The complete genome of alfalfa dwarf virus is obtained. • An integrated localization and interaction map for ADV is determined. • ADV has a genome sequence similarity and evolutionary links with cytorhabdoviruses. • ADV protein localization and interaction data show an association with the nucleus. • ADV combines properties of both cytoplasmic and nuclear plant rhabdoviruses

  1. Deep sequencing analysis of HBV genotype shift and correlation with antiviral efficiency during adefovir dipivoxil therapy.

    Directory of Open Access Journals (Sweden)

    Yuwei Wang

    Full Text Available Viral genotype shift in chronic hepatitis B (CHB patients during antiviral therapy has been reported, but the underlying mechanism remains elusive.38 CHB patients treated with ADV for one year were selected for studying genotype shift by both deep sequencing and Sanger sequencing method.Sanger sequencing method found that 7.9% patients showed mixed genotype before ADV therapy. In contrast, all 38 patients showed mixed genotype before ADV treatment by deep sequencing. 95.5% mixed genotype rate was also obtained from additional 200 treatment-naïve CHB patients. Of the 13 patients with genotype shift, the fraction of the minor genotype in 5 patients (38% increased gradually during the course of ADV treatment. Furthermore, responses to ADV and HBeAg seroconversion were associated with the high rate of genotype shift, suggesting drug and immune pressure may be key factors to induce genotype shift. Interestingly, patients with genotype C had a significantly higher rate of genotype shift than genotype B. In genotype shift group, ADV treatment induced a marked enhancement of genotype B ratio accompanied by a reduction of genotype C ratio, suggesting genotype C may be more sensitive to ADV than genotype B. Moreover, patients with dominant genotype C may have a better therapeutic effect. Finally, genotype shifts was correlated with clinical improvement in terms of ALT.Our findings provided a rational explanation for genotype shift among ADV-treated CHB patients. The genotype and genotype shift might be associated with antiviral efficiency.

  2. 17 CFR 275.206(4)-2 - Custody of funds or securities of clients by investment advisers.

    Science.gov (United States)

    2010-04-01

    ... certificate on Form ADV-E (17 CFR 279.8) with the Commission within 120 days of the time chosen by the... Regulation S-X (17 CFR 210.1-02(d))): (i) At least annually and distributes its audited financial statements... companies. You are not required to comply with this section (17 CFR 275.206(4)-2) with respect to...

  3. Adenovirus 36 and Obesity: An Overview

    Directory of Open Access Journals (Sweden)

    Eleonora Ponterio

    2015-07-01

    Full Text Available There is an epidemic of obesity starting about 1980 in both developed and undeveloped countries definitely associated with multiple etiologies. About 670 million people worldwide are obese. The incidence of obesity has increased in all age groups, including children. Obesity causes numerous diseases and the interaction between genetic, metabolic, social, cultural and environmental factors are possible cofactors for the development of obesity. Evidence emerging over the last 20 years supports the hypothesis that viral infections may be associated with obesity in animals and humans. The most widely studied infectious agent possibly linked to obesity is adenovirus 36 (Adv36. Adv36 causes obesity in animals. In humans, Adv36 associates with obesity both in adults and children and the prevalence of Adv36 increases in relation to the body mass index. In vivo and in vitro studies have shown that the viral E4orf1 protein (early region 4 open reading frame 1, Adv mediates the Adv36 effect including its adipogenic potential. The Adv36 infection should therefore be considered as a possible risk factor for obesity and could be a potential new therapeutic target in addition to an original way to understand the worldwide rise of the epidemic of obesity. Here, the data indicating a possible link between viral infection and obesity with a particular emphasis to the Adv36 will be reviewed.

  4. Acute interstitial pneumonia in mink kits inoculated with defined isolates of Aleutian mink disease parvovirus

    DEFF Research Database (Denmark)

    Alexandersen, Søren; Larsen, S; Aasted, B;

    1994-01-01

    The present study addressed the causal role of Aleutian mink disease parvovirus (ADV) in acute interstitial pneumonia in mink kits. All the examined isolates of ADV caused interstitial pneumonia in newborn kits, although the severity of disease and the mortality varied. These findings indicate that...

  5. Passive transfer of antiviral antibodies restricts replication of Aleutian mink disease parvovirus in vivo

    DEFF Research Database (Denmark)

    Alexandersen, Søren; Larsen, S; Cohn, A.;

    1989-01-01

    When mink kits were infected neonatally with a highly virulent strain of Aleutian disease virus (ADV), 100% of both Aleutian and non-Aleutian genotype mink died of interstitial pneumonia characterized by permissive ADV infection of alveolar type II cells. Treatment of infected kits with either mi...

  6. Adenovirus vectors lacking virus-associated RNA expression enhance shRNA activity to suppress hepatitis C virus replication

    Science.gov (United States)

    Pei, Zheng; Shi, Guoli; Kondo, Saki; Ito, Masahiko; Maekawa, Aya; Suzuki, Mariko; Saito, Izumu; Suzuki, Tetsuro; Kanegae, Yumi

    2013-12-01

    First-generation adenovirus vectors (FG AdVs) expressing short-hairpin RNA (shRNA) effectively downregulate the expressions of target genes. However, this vector, in fact, expresses not only the transgene product, but also virus-associated RNAs (VA RNAs) that disturb cellular RNAi machinery. We have established a production method for VA-deleted AdVs lacking expression of VA RNAs. Here, we showed that the highest shRNA activity was obtained when the shRNA was inserted not at the popularly used E1 site, but at the E4 site. We then compared the activities of shRNAs against hepatitis C virus (HCV) expressed from VA-deleted AdVs or conventional AdVs. The VA-deleted AdVs inhibited HCV production much more efficiently. Therefore, VA-deleted AdVs were more effective than the currently used AdVs for shRNA downregulation, probably because of the lack of competition between VA RNAs and the shRNAs. These VA-deleted AdVs might enable more effective gene therapies for chronic hepatitis C.

  7. Ultrasound-triggered drug delivery using acoustic droplet vaporization

    Science.gov (United States)

    Fabiilli, Mario Leonardo

    The goal of targeted drug delivery is the spatial and temporal localization of a therapeutic agent and its associated bioeffects. One method of drug localization is acoustic droplet vaporization (ADV), whereby drug-laden perfluorocarbon (PFC) emulsions are vaporized into gas bubbles using ultrasound, thereby releasing drug locally. Transpulmonary droplets are converted into bubbles that occlude capillaries, sequestering the released drug within an organ or tumor. This research investigates the relationship between the ADV and inertial cavitation (IC) thresholds---relevant for drug delivery due to the bioffects generated by IC---and explores the delivery of lipophilic and hydrophilic compounds using PFC double emulsions. IC can positively and negatively affect ultrasound mediated drug delivery. The ADV and IC thresholds were determined for various bulk fluid, droplet, and acoustic parameters. At 3.5 MHz, the ADV threshold occurred at a lower rarefactional pressure than the IC threshold. The results suggest that ADV is a distinct phenomenon from IC, the ADV nucleus is internal to the droplet, and the IC nucleus is the bubble generated by ADV. The ADV triggered release of a lipophilic chemotherapeutic agent, chlorambucil (CHL), from a PFC-in-oil-in-water emulsion was explored using plated cells. Cells exposed to a CHL-loaded emulsion, without ADV, displayed 44% less growth inhibition than cells exposed to an equal concentration of CHL in solution. Upon ADV of the CHL-loaded emulsion, the growth inhibition increased to the same level as cells exposed to CHL in solution. A triblock copolymer was synthesized which enabled the formulation of stable water-in-PFC-in-water (W1/PFC/W2) emulsions. The encapsulation of fluorescein in the W1 phase significantly decreased the mass flux of fluorescein; ADV was shown to completely release the fluorescein from the emulsions. ADV was also shown to release thrombin, dissolved in the W1 phase, which could be used in vivo to extend

  8. Passive transfer of antiviral antibodies restricts replication of Aleutian mink disease parvovirus in vivo

    DEFF Research Database (Denmark)

    Alexandersen, Søren; Larsen, S; Cohn, A.;

    1989-01-01

    anti-ADV gamma globulin or mouse monoclonal antibodies against ADV structural proteins reduced mortality by 50 to 75% and drastically reduced the severity of clinical signs. Interestingly, mink kits that survived the acute pulmonary disease all developed the chronic form of immune complex......When mink kits were infected neonatally with a highly virulent strain of Aleutian disease virus (ADV), 100% of both Aleutian and non-Aleutian genotype mink died of interstitial pneumonia characterized by permissive ADV infection of alveolar type II cells. Treatment of infected kits with either mink......-mediated Aleutian disease. Thus, the antibodies directed against ADV structural proteins were capable of modulating the in vivo pathogenicity from an acute fulminant disease to a chronic immune complex-mediated disorder. The mechanism of this modulation was examined by strand-specific in situ hybridization. We...

  9. Draft Function Allocation Framework and Preliminary Technical Basis for Advanced SMR Concepts of Operations

    Energy Technology Data Exchange (ETDEWEB)

    Jacques Hugo; John Forester; David Gertman; Jeffrey Joe; Heather Medema; Julius Persensky; April Whaley

    2013-08-01

    This report presents preliminary research results from the investigation into the development of new models and guidance for Concepts of Operations in advanced small modular reactor (AdvSMR) designs. AdvSMRs are nuclear power plants (NPPs), but unlike conventional large NPPs that are constructed on site, AdvSMRs systems and components will be fabricated in a factory and then assembled on site. AdvSMRs will also use advanced digital instrumentation and control systems, and make greater use of automation. Some AdvSMR designs also propose to be operated in a multi-unit configuration with a single central control room as a way to be more cost-competitive with existing NPPs. These differences from conventional NPPs not only pose technical and operational challenges, but they will undoubtedly also have regulatory compliance implications, especially with respect to staffing requirements and safety standards.

  10. Dural mast cell degranulation is a putative mechanism for headache induced by PACAP-38

    DEFF Research Database (Denmark)

    Baun, Michael; Pedersen, Martin Holst Friborg; Olesen, Jes;

    2012-01-01

    not VIP cause degranulation of mast cells in peritoneum and in dura mater. METHODS: The degranulatory effects of PACAP-38, PACAP-27 and VIP were investigated by measuring the amount of N-acetyl-β-hexosaminidase released from isolated peritoneal mast cells and from dura mater attached to the skull of...

  11. 75 FR 51823 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2010-08-23

    ... model features a TGF- 1 transgene for which expression is blocked by a floxed enhanced green fluorescent protein (EGFP) gene downstream of the promoter. Excision of the EGFP gene by Cre recombinase allows... Human Recombinant MATER Protein Description of Technology: The inventors have identified MATER, a...

  12. Acoustic Droplet Vaporization in Biology and Medicine

    Directory of Open Access Journals (Sweden)

    Chung-Yin Lin

    2013-01-01

    Full Text Available This paper reviews the literature regarding the use of acoustic droplet vaporization (ADV in clinical applications of imaging, embolic therapy, and therapeutic delivery. ADV is a physical process in which the pressure waves of ultrasound induce a phase transition that causes superheated liquid nanodroplets to form gas bubbles. The bubbles provide ultrasonic imaging contrast and other functions. ADV of perfluoropentane was used extensively in imaging for preclinical trials in the 1990s, but its use declined rapidly with the advent of other imaging agents. In the last decade, ADV was proposed and explored for embolic occlusion therapy, drug delivery, aberration correction, and high intensity focused ultrasound (HIFU sensitization. Vessel occlusion via ADV has been explored in rodents and dogs and may be approaching clinical use. ADV for drug delivery is still in preclinical stages with initial applications to treat tumors in mice. Other techniques are still in preclinical studies but have potential for clinical use in specialty applications. Overall, ADV has a bright future in clinical application because the small size of nanodroplets greatly reduces the rate of clearance compared to larger contrast agent bubbles and yet provides the advantages of ultrasonographic contrast, acoustic cavitation, and nontoxicity of conventional perfluorocarbon contrast agent bubbles.

  13. Low-Dose Adefovir-Induced Hypophosphatemic Osteomalacia on Whole-Body Bone Scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Hoon; Won, Kyoung Sook; Song, Bongil; Jo, Il; Zeon, Seok Kil [Keimyung Univ., Daegu (Korea, Republic of)

    2013-12-15

    While adefovir dipivoxil (ADV) effectively suppresses the hepatitis B virus, it can cause proximal renal tubular dysfunction leading to phosphate wasting. The safety of low-dose ADV (a dose of 10 mg/day), which does not induce clinically significant nephrotoxicity, is well recognized, but a few cases of hypophosphatemic osteomalacia (HO) caused by low-dose ADV therapy have recently been reported. Although HO induced by low-dose ADV therapy is rare, the presence of bone pain in patients treated with ADV should be monitored. Bone scintigraphy can be performed to confirm the occurrence of osteomalacia and to determine the disease extent. Bone scintigraphic and radiological image findings with a brief review of the literature are presented in this article. We report two cases of HO induced by low-dose ADV therapy that showed multifocal increased radiotracer uptakes in the bilateral bony ribs, spines, pelvic bones and lower extremities on whole-body bone scintigraphy. Bone pain gradually improved after phosphate supplementation and by changing the antiviral agent. Whole-body bone scintigraphy is a highly sensitive imaging tool and can show disease extent at once in the setting of the wide range of the clinical spectrum with nonspecific radiological findings. Furthermore, frequent involvement of the lower extremities, as a result of maximum weight bearing, could be an additional scintigraphic clue for the diagnosis of HO. These cases could be helpful for both clinicians prescribing ADV and nuclear physicians to prevent delayed diagnosis and plan further appropriate treatment.

  14. Subclinical porcine circovirus type 2 infection does not modulate the immune response to an Aujeszky's disease virus vaccine.

    Science.gov (United States)

    Díaz, Ivan; Cortey, Martí; Darwich, Laila; Sibila, Marina; Mateu, Enric; Segalés, Joaquim

    2012-10-01

    Porcine circovirus type 2 (PCV2) negatively modulates the immune response in vitro. The objective of this study was to investigate if PCV2 interferes with the development of the immune response to Aujeszky's disease virus (ADV) vaccine, using an in vivo experimental subclinical model. Pigs were divided into four groups: (group CC) not infected with PCV2 and not vaccinated against ADV; (group IC) infected with PCV2 but not vaccinated against ADV; (group CV) not infected with PCV2 but vaccinated against ADV, and (group IV) infected with PCV2 and vaccinated against ADV. Pigs in groups IC and IV were inoculated intranasally with PCV2 and 14 days later, pigs in the CV and IV groups were vaccinated IM with a gE(-)tk(-) attenuated ADV vaccine. Clinical signs and weight gains were recorded from days 0 to 35 post-PCV2 inoculation (PI), at which point the pigs were euthanased and examined post-mortem. Throughout the experiment the PCV2 load was quantified in serum, antibodies to PCV2 and ADV were determined and antigen-specific cellular responses against both viruses were measured using an interferon-γ ELISPOT. PCV2 inoculated animals developed subclinical infection and had lower weight gain relative to non-infected controls. No differences were observed between the CV and IV groups in terms of the humoral or cellular immune responses to vaccination against Aujeszky's disease, suggesting that subclinical infection with PCV2 does not alter the response to this vaccine. PMID:22464756

  15. Low-Dose Adefovir-Induced Hypophosphatemic Osteomalacia on Whole-Body Bone Scintigraphy

    International Nuclear Information System (INIS)

    While adefovir dipivoxil (ADV) effectively suppresses the hepatitis B virus, it can cause proximal renal tubular dysfunction leading to phosphate wasting. The safety of low-dose ADV (a dose of 10 mg/day), which does not induce clinically significant nephrotoxicity, is well recognized, but a few cases of hypophosphatemic osteomalacia (HO) caused by low-dose ADV therapy have recently been reported. Although HO induced by low-dose ADV therapy is rare, the presence of bone pain in patients treated with ADV should be monitored. Bone scintigraphy can be performed to confirm the occurrence of osteomalacia and to determine the disease extent. Bone scintigraphic and radiological image findings with a brief review of the literature are presented in this article. We report two cases of HO induced by low-dose ADV therapy that showed multifocal increased radiotracer uptakes in the bilateral bony ribs, spines, pelvic bones and lower extremities on whole-body bone scintigraphy. Bone pain gradually improved after phosphate supplementation and by changing the antiviral agent. Whole-body bone scintigraphy is a highly sensitive imaging tool and can show disease extent at once in the setting of the wide range of the clinical spectrum with nonspecific radiological findings. Furthermore, frequent involvement of the lower extremities, as a result of maximum weight bearing, could be an additional scintigraphic clue for the diagnosis of HO. These cases could be helpful for both clinicians prescribing ADV and nuclear physicians to prevent delayed diagnosis and plan further appropriate treatment

  16. Enfermedad neurologica por adenovirus Neurologic disease due to adenovirus infection

    Directory of Open Access Journals (Sweden)

    Cristina L. Lema

    2005-06-01

    Full Text Available El objetivo de este trabajo fue determinar la prevalencia de adenovirus (ADV en las infecciones del sistema nervioso central (SNC. Se analizaron 108 muestras de líquido cefalorraquídeo (LCR provenientes de 79 casos de encefalitis, 7 meningitis y 22 de otras patologías neurológicas, recibidas en el período 2000-2002. Cuarenta y nueve (47.35% se obtuvieron de pacientes inmunocomprometidos. La presencia de ADV se investigó mediante reacción en cadena de la polimerasa en formato anidado (Nested-PCR. La identificación del genogrupo se realizó mediante análisis filogenético de la secuencia nucleotídica parcial de la región que codifica para la proteína del hexón. Se detectó la presencia de ADV en 6 de 108 (5.5% muestras de LCR analizadas. Todos los casos positivos pertenecieron a pacientes con encefalitis que fueron 79, (6/79, 7.6%. No se observó diferencia estadísticamente significativa entre los casos de infección por ADV en pacientes inmunocomprometidos e inmunocompetentes (p>0.05. Las cepas de ADV detectadas se agruparon en los genogrupos B1 y C. En conclusión, nuestros resultados describen el rol de los ADV en las infecciones neurológicas en Argentina. La información presentada contribuye al conocimiento de su epidemiología, en particular en casos de encefalitis.The aim of this study was to assess the prevalence of adenovirusm (ADV infections in neurological disorders. A total of 108 cerebrospinal fluid (CSF samples from 79 encephalitis cases, 7 meningitis and 22 other neurological diseases analysed in our laboratory between 2000 and 2002 were studied. Forty nine (47.4% belonged to immunocompromised patients. Viral genome was detected using nested polymerase chain reaction (Nested-PCR and ADV genotypes were identified using partial gene sequence analysis of hexon gene. Adenovirus were detected in 6 of 108 (5.5% CSF samples tested. All of these were from encephalitis cases, 6/79, representing 7.6% of them. No statistically

  17. Adenoviruses in Côte d`Ivoire: investigation of diversity and interspecies transmission

    OpenAIRE

    Pauly, Maude

    2015-01-01

    Sub-Saharan Africa is considered to be a hotspot for emerging infectious diseases (EID) and the majority of these EID in humans originated from animal hosts and many are caused by viruses. In this first study on Adenovirus (AdV) in humans and domestic animals in Côte d`Ivoire, not only the prevalence and diversity of AdV shedding was assessed, but also the zoonotic and recombination potential of AdV was elucidated. The study region is situated next to the Taï National Park, the largest tropic...

  18. SYNERGISTIC EFFICACY OF ADENOVIRUS-MEDIATED BCL-XS GENE TRANSFER AND TOPOTECAN IN OVARIAN CANCER CELL

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To observe the synergistic efficacy between Adenovirus-mediated bcl-Xs(Adv-bcl-Xs) gene transfer and chemotherapy on ovarian cancer cell growth. Methods: NuTu-19 cells were infected by different titers of Adv-bcl-Xs and treated with topotecan in the meantime. Cell proliferation was measured 3 days later by MTT. Graphical representations and statistical analyses for their interaction in tumor cells were done. Results: The statistical result and Graphical representations of the statistical modeling showed synergy effect on cell growth inhibition (P<0.01). Conclusion: There were synergistic efficacies between Adv-bcl-Xs gene therapy and Topotecan in ovarian cancer cell growth.

  19. A novel adenovirus of Western lowland gorillas (Gorilla gorilla gorilla)

    OpenAIRE

    Ludwig Carsten; Head Josephine; Robbins Martha M; Boesch Christophe; Scuda Nelly; Leendertz Fabian H; Wevers Diana; Kühn Joachim; Ehlers Bernhard

    2010-01-01

    Abstract Adenoviruses (AdV) broadly infect vertebrate hosts including a variety of primates. We identified a novel AdV in the feces of captive gorillas by isolation in cell culture, electron microscopy and PCR. From the supernatants of infected cultures we amplified DNA polymerase (DPOL), preterminal protein (pTP) and hexon gene sequences with generic pan primate AdV PCR assays. The sequences in-between were amplified by long-distance PCRs of 2 - 10 kb length, resulting in a final sequence of...

  20. Quantifying signal changes in nano-wire based biosensors

    DEFF Research Database (Denmark)

    De Vico, Luca; Sørensen, Martin Hedegård; Iversen, Lars;

    2011-01-01

    In this work, we present a computational methodology for predicting the change in signal (conductance sensitivity) of a nano-BioFET sensor (a sensor based on a biomolecule binding another biomolecule attached to a nano-wire field effect transistor) upon binding its target molecule. The methodology...... quantitative predictions when key experimental parameters (such as the charge carrier density of the nano-wire or receptor density on the device surface) can be determined (and reported) more accurately. © 2011 The Royal Society of Chemistry.......-workers [Li et al., Proteins: Struct., Funct., Bioinf., 2005, 61, 704-721, Bas et al., Proteins: Struct., Funct., Bioinf., 2008, 73, 765-783]. The predicted change in conductance sensitivity based on this methodology is compared to previously published data on nano-BioFET sensors obtained by other groups. In...

  1. Astrophysical S-factors of radiative capture of protons on 2H, 3H, 6Li and 12C nuclei

    OpenAIRE

    Dubovichenko, S. B.; Dzhazairov-Kakhramanov, A. V.

    2010-01-01

    We have considered the possibility to describe the astrophysical S-factors of some light atomic nuclei on the basis of the potential cluster model by taking into account the supermultiplet symmetry of wave functions and splitting the orbital states according to Young's schemes. Such an approach allows analyzing the structure of inter-cluster interactions, to determine the presence of allowed and forbidden states in the interaction potential and so the number of nodes of the orbital wave funct...

  2. Role of Extracellular Vesicles and microRNAs on Dysfunctional Angiogenesis during Preeclamptic Pregnancies

    OpenAIRE

    Escudero, Carlos A.; Herlitz, Kurt; Troncoso, Felipe; Acurio, Jesenia; Aguayo, Claudio; Roberts, James M.; Truong, Grace; Duncombe, Gregory; Rice, Gregory; Salomon, Carlos

    2016-01-01

    Preeclampsia is a syndrome characterized by hypertension during pregnancy, which is a leading cause of morbidity and mortality in both mother and newborn in developing countries. Some advances have increased the understanding of pathophysiology of this disease. For example, reduced utero-placental blood flow associated with impaired trophoblast invasion may lead to a hypoxic placenta that releases harmful materials into the maternal and feto-placental circulation and impairs endothelial funct...

  3. The command team experimental test-bed stage 1: design and build of a submarine command room simulator

    OpenAIRE

    Roberts, A; Stanton, N A; Fay, D

    2015-01-01

    The command room system has developed across a century of submarine operations and so reflects a high state of evolution, but that does not mean that the system cannot be improved upon. Technological advances have resulted in the retrospective fitting of upgrades which may not have maximized the potential improvements offered. Future challenges for command teams in almost every domain include increasing amounts of data coupled with more automated systems and reduced manning. To optimise funct...

  4. Being Close and Being Social: Peer Ratings of Distinct Aspects of Young Adult Social Competence

    OpenAIRE

    Larson, Justine J.; Whitton, Sarah W.; HAUSER, STUART T.; Allen, Joseph P.

    2007-01-01

    The present study had three main objectives: (1) to develop and validate scales of young adult social competence in two domains, close relationships and social groups, using peer ratings of California Q-sort (Block, 1974; Kremen & Block, 2002) items; (2) to test the hypothesis that social competence is associated with young adult well-being and ego development; (3) to test the hypothesis that close relationship competence aligns more closely than social group competence with young adult funct...

  5. Relative stabilities of two difluorodiazene isomers: density functional and molecular orbital studies

    OpenAIRE

    Jana, Jibanananda

    2012-01-01

    Jibanananda JanaDepartment of Chemistry, Krishnagar Government College, Krishnagar, Nadia, West Bengal, IndiaAbstract: The N–N bond length in the cis isomer of difluorodiazene is shorter than that in the trans isomer, giving the cis isomer higher stability. The energy partitioning approach identifies the necessary and dictating parameters responsible for the higher N–N bond energy and higher non-bonded F–F interaction energy in the cis isomer. Using density funct...

  6. Molecular orbital tomography beyond the plane wave approximation

    OpenAIRE

    Li, Yang; Zhu, Xiaosong; Lan, Pengfei; Zhang, Qingbin; Qin, Meiyan; Lu, Peixiang

    2014-01-01

    The use of plane wave approximation in molecular orbital tomography via high-order harmonic generation has been questioned since it was proposed, owing to the fact that it ignores the essential property of the continuum wave function. To address this problem, we develop a theory to retrieve the valence molecular orbital directly utilizing molecular continuum wave function which takes into account the influence of the parent ion field on the continuum electrons. By transforming this wave funct...

  7. Wage Mobility in East and West Germany

    OpenAIRE

    Regina T. Riphahn; Schnitzlein, Daniel D.

    2011-01-01

    This article studies the long run patterns and explanations of wage mobility as a characteristic of regional labor markets. Using German administrative data we describe wage mobility since 1975 in West and since 1992 in East Germany. Wage mobility declined substantially in East Germany in the 1990s and moderately in East and West Germany since the late 1990s. Therefore, wage mobility does not balance recent increases in cross-sectional wage inequality. We apply RIF (recentered influence funct...

  8. Budżetowanie zadaniowe jako innowacyjna forma zarządzania w publicznym systemie finansowym (na przykładzie województwa łódzkiego)

    OpenAIRE

    Guziejewska, Beata; Hajdys, Dagmara

    2012-01-01

    The aim of this discussion is to present the object and scope of the performance budget of the Łódź Voivodeship against the background of the nature, significance and limitations of performance-based budgeting as an innovative form of public management. The performance indicators for public tasks in the voivodeship budget, their functionality and informative value were evaluated. The performance budget of the governmental voivodeship administration in Poland is based on a set of several funct...

  9. Methylprednisolone-hemisuccinate and its metabolites in serum, urine and bile from two patients with acute graft rejection.

    OpenAIRE

    Lawson, G. J.; Chakraborty, J; Tredger, J M; Baylis, E M

    1995-01-01

    Methylprednisolone-hemisuccinate (MPHS), methylprednisolone (MP), 20-alpha-hydroxy- (20 alpha HMP) and 20-beta-hydroxymethyl-prednisolone (20 beta HMP) concentrations were measured in serum, urine and bile from two liver transplant recipients who had received 1 g MPHS by a 1 h intravenous infusion for treatment of an acute rejection episode. These patients excreted similar total amounts of the dose in urine as patients with rheumatoid arthritis (historical controls) who had normal liver funct...

  10. Disulphide Bridges of Phospholipase C of Chlamydomonas reinhardtii Modulates Lipid Interaction and Dimer Stability

    OpenAIRE

    Mayanka Awasthi; Jyoti Batra; Suneel Kateriya

    2012-01-01

    BACKGROUND: Phospholipase C (PLC) is an enzyme that plays pivotal role in a number of signaling cascades. These are active in the plasma membrane and triggers cellular responses by catalyzing the hydrolysis of membrane phospholipids and thereby generating the secondary messengers. Phosphatidylinositol-PLC (PI-PLC) specifically interacts with phosphoinositide and/or phosphoinositol and catalyzes specific cleavage of sn-3- phosphodiester bond. Several isoforms of PLC are known to form and funct...

  11. Third Order Trace Formula

    Indian Academy of Sciences (India)

    Arup Chattopadhyay; Kalyan B Sinha

    2013-11-01

    In J. Funct. Anal. 257 (2009) 1092–1132, Dykema and Skripka showed the existence of higher order spectral shift functions when the unperturbed self-adjoint operator is bounded and the perturbation is Hilbert–Schmidt. In this article, we give a different proof for the existence of spectral shift function for the third order when the unperturbed operator is self-adjoint (bounded or unbounded, but bounded below).

  12. Effect of a High-Intensity Exercise Program on Physical Function and Mental Health in Nursing Home Residents with Dementia: An Assessor Blinded Randomized Controlled Trial

    OpenAIRE

    Telenius, Elisabeth Wiken; Engedal, Knut; Bergland, Astrid

    2015-01-01

    Background Dementia is among the leading causes of functional loss and disability in older adults. Research has demonstrated that nursing home patients without dementia can improve their function in activities of daily living, strength, balance and mental well being by physical exercise. The evidence on effect of physical exercise among nursing home patients with dementia is scarce and ambiguous. Thus, the primary objective of this study was to investigate the effect of a high intensity funct...

  13. Compression analysis as a tool for technical characterization and classification of pharmaceutical powders

    OpenAIRE

    Nordström, Josefina

    2008-01-01

    There are today strong incentives for an increased understanding of material properties and manufacturing processes to facilitate the development of new technologies in the pharmaceutical industry. The purpose of this thesis was to suggest methods requiring a low sample amount for characterization of technical properties of powders. Compression analysis was used to evaluate the formulation relevance of some compression equations. Using the mechanics of single granules to estimate powder funct...

  14. Helicobacter pylori HP0231 Influences Bacterial Virulence and Is Essential for Gastric Colonization

    OpenAIRE

    Zhong, Yu; Anderl, Florian; Kruse, Tobias; Schindele, Franziska; Jagusztyn-Krynicka, Elżbieta Katarzyna; Fischer, Wolfgang; Gerhard, Markus; Mejías-Luque, Raquel

    2016-01-01

    The Dsb protein family is responsible for introducing disulfide bonds into nascent proteins in prokaryotes, stabilizing the structure of many proteins. Helicobacter pylori HP0231 is a Dsb-like protein, shown to catalyze disulfide bond formation and to participate in redox homeostasis. Notably, many H. pylori virulence factors are stabilized by the formation of disulfide bonds. By employing H. pylori HP0231 deficient strains we analyzed the effect of lack of this bacterial protein on the funct...

  15. PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s

    OpenAIRE

    Corona, Juan Carlos; Duchen, Michael R.

    2014-01-01

    The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was initially identified through its role in the regulation of glucose and lipid metabolism and cell differentiation. It also influences the expression or activity of a number of genes in a variety of signalling networks. These include regulation of redox balance, fatty acid oxidation, immune responses and mitochondrial funct...

  16. The specificity of action knowledge in sensory and motor systems

    OpenAIRE

    Watson, Christine E.; Cardillo, Eileen R.; Bianca eBromberger; Anjan eChatterjee

    2014-01-01

    Neuroimaging studies have found that sensorimotor systems are engaged when participants observe actions or comprehend action language. However, most of these studies have asked the binary question of whether action concepts are embodied or not, rather than whether sensory and motor areas of the brain contain graded amounts of information during putative action simulations. To address this question, we used repetition suppression (RS) functional magnetic resonance imaging to determine if funct...

  17. Relativistic wave functions and energies for nonzero angular momentum states in light-front dynamics

    OpenAIRE

    Karmanov, V. A.; Mangin-Brinet, M.; Carbonell, J.

    2000-01-01

    Light-front dynamics (LFD) is a powerful approach to the theory of relativistic composite systems (hadrons in the quark models and relativistic nucleons in nuclei). Its explicitly covariant version has been recently applied with success to describe the new CEBAF/TJNAF data on the deuteron electromagnetic form factors. The solutions used in were however not obtained from solving exactly the LFD equations but by means of a perturbative calculation with respect to the non relativistic wave funct...

  18. A biochemical model for characterising the surface-active phospolipid bilayer of articular cartilage relative to acid-base equilibrium

    OpenAIRE

    Z. Pawlak; J. Kotynska; Figaszewski, Z A; A. Gadomski; A. Gudaniec; A. Oloyede

    2008-01-01

    Purpose: This paper, addresses the question of how changes in acid - base equilibrium influence change in thecharge density of the phospholipid bilayer on articular cartilage surfaces during lubrication.Design/methodology/approach: Liposomes have been used to mimic biological phospholipid membranes onarticular cartilage surface where proteins are bounded, ions are transported, energy is transducted, and cellular processestake place. The charge density of the membrane was determined as a funct...

  19. Local stability of perfect alignment for a spatially homogeneous kinetic model

    OpenAIRE

    Degond, Pierre; Frouvelle, Amic; Raoul, Gaël

    2014-01-01

    International audience We prove the nonlinear local stability of Dirac masses for a kinetic model of alignment of particles on the unit sphere, each point of the unit sphere representing a direction. A population concentrated in a Dirac mass then corresponds to the global alignment of all individuals. The main difficulty of this model is the lack of conserved quantities and the absence of an energy that would decrease for any initial condition. We overcome this difficulty thanks to a funct...

  20. Orthogonal functionalization of nanoporous substrates: control of 3D surface functionality.

    OpenAIRE

    Thomas D. Lazzara; Kliesch, Torben-Tobias; Janshoff, Andreas; Steinem, Claudia

    2011-01-01

    Anodic aluminum oxide (AAO) membranes with aligned, cylindrical, nonintersecting pores were selectively functionalized in order to create dual-functionality substrates with different pore-rim and pore-interior surface functionalities, using silane chemistry. We used a two-step process involving an evaporated thin gold film to protect the underlying surface functionality of the pore rims. Subsequent treatment with oxygen plasma of the modified AAO membrane removed the unprotected organic funct...

  1. Tunnelling in organic superconductors

    OpenAIRE

    Bolech, C. J.; Giamarchi, T.

    2005-01-01

    We discuss the possibility of deciding on the symmetry of the superconducting phase in the organic superconductors (Bechgaard salts), using tunnelling experiments. We first briefly review the properties of organic superconductors, and the possibility to have unconventional (triplet) superconductivity in these systems. We then present a simple scheme for computing the full current-voltage characteristics for tunnelling experiments within the framework of the non-equilibrium Keldysh Green funct...

  2. Temperature-dependent alterations in metabolic enzymes and proteins of three ecophysiologically different species of earthworms

    OpenAIRE

    Tripathi, G.; N. Kachhwaha; I. Dabi; N. Bandooni

    2011-01-01

    The effects of varying temperatures (12 - 44° C) on the specific activity of cytoplasmic malate dehydrogenase ((cMDH), mitochondrial malate dehydrogenase (mMDH) and lactate dehydrogenase (LDH) of some earthworms (Metaphire posthuma, Perionyx sansibaricus and Lampito mauritii) were studied. The effects of different temperatures on supernatant and mitochondrial protein contents were also investigated. The specific activities of cMDH, mMDH and LDH of the earthworms decreased gradually as a funct...

  3. Subpixel Image Registration by Estimating the Polyphase Decomposition of the Cross Power Spectrum

    OpenAIRE

    Shekarforoush, Hassan; Berthod, Marc; Zerubia, Josiane

    1995-01-01

    A method of registering images at subpixel accuracy has been propos ed, which does not resort to interpolation. The method is based on the phase co rrelation method and is remarkably robust to correlated noise and uniform varia tions of luminance. We have shown that the cross power spectrum of two images, containing subpixel shifts, is a polyphase decomposition of a Dirac delta funct ion. By estimating the sum of polyphase components one can then determine subpi xel shifts along each axis.

  4. Bayesian estimation of parameters in a regional hydrological model

    OpenAIRE

    Engeland, K.; Gottschalk, L.

    2002-01-01

    This study evaluates the applicability of the distributed, process-oriented Ecomag model for prediction of daily streamflow in ungauged basins. The Ecomag model is applied as a regional model to nine catchments in the NOPEX area, using Bayesian statistics to estimate the posterior distribution of the model parameters conditioned on the observed streamflow. The distribution is calculated by Markov Chain Monte Carlo (MCMC) analysis. The Bayesian method requires formulation of a likelihood funct...

  5. Composite scores for executive function items: demographic heterogeneity and relationships with quantitative MRI

    OpenAIRE

    Crane, Paul K.; Narasimhalu, Kaavya; Gibbons, Laura E.; Pedraza, Otto; Mehta, Kala M.; Tang, Yuxiao; Manly, Jennifer J.; Reed, Bruce R.; Mungas, Dan M.

    2008-01-01

    Accurate neuropsychological assessment of older individuals from heterogeneous backgrounds is a major challenge. Education, ethnicity, language, and age are associated with scale level differences in test scores, but item level bias might contribute to these differences. We evaluated several strategies for dealing with item and scale level demographic influences on a measure of executive abilities defined by working memory and fluency tasks. We determined the impact of differential item funct...

  6. Energy Aware Reliable Routing Protocol (EARRP) for Mobile AdHoc Networks Using Bee Foraging Behavior and Ant Colony Optimization

    OpenAIRE

    K. G. Santhiya; Arumugam, N.

    2012-01-01

    Energy aware reliable routing in mobile ad hoc networks is an astonishing task and in this paper we propose to design, develop such protocol which will be a good solution. For developing such protocol EARRP, two swarm intelligence techniques are involved namely ant colony optimization and bee colony foraging behavior. For optimization, we proposed adaptive solutions in order to estimate MAC overhead, link eminence and residual energy. After estimating the above said metrics, the fitness funct...

  7. Health Considerations Regarding Horizontal Transfer of Microbial Transgenes Present in Genetically Modified Crops

    OpenAIRE

    Gijs A. Kleter; Peijnenburg, Ad A. C. M.; Aarts, Henk J.M.

    2005-01-01

    The potential effects of horizontal gene transfer on human health are an important item in the safety assessment of genetically modified organisms. Horizontal gene transfer from genetically modified crops to gut microflora most likely occurs with transgenes of microbial origin. The characteristics of microbial transgenes other than antibiotic-resistance genes in market-approved genetically modified crops are reviewed. These characteristics include the microbial source, natural function, funct...

  8. Genetic programming theory and practice XII

    CERN Document Server

    Riolo, Rick; Kotanchek, Mark

    2015-01-01

    These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics in this volume include: gene expression regulation, novel genetic models for glaucoma, inheritable epigenetics, combinators in genetic programming, sequential symbolic regression, system dynamics, sliding window symbolic regression, large feature problems, alignment in the error space, HUMIE winners, Boolean multiplexer funct

  9. Functional foods in human nutrition

    OpenAIRE

    ZEVLOVÁ, Veronika

    2013-01-01

    Bachelor thesis deals with functional food and their role in human nutrition. The history of functional food, their characteristics, components, evaluation of individual species and the impact on the health of the consumer is described here. A lot of researches are focused on the topic of functional food, but no legally definition have been established yet. Even in the Czech Republic or the EU. Only the certain designations are used, which have a small deviations in different countries. Funct...

  10. Suspended photonic waveguide arrays for submicrometer alignment

    OpenAIRE

    Peters, T. J.; Tichem, M.; Staufer, U.

    2014-01-01

    This paper presents a new alignment concept for the alignment of multichannel photonic intergrated circuits (PICs) using flexible photonic waveguides on one of the PICs that are positionable by integrated micro electro mechanical system (MEMS) actuators. The concept aims for high precision and high degree of assembly process automation. The proposed concept includes pre-alignment of both PICs on a common substrate followed by fine-alignment using the on-chip flexible waveguides and MEMS funct...

  11. Functional independence measure in patients with intermittent claudication

    OpenAIRE

    Caroline Shihara de Assis; Letícia de Carvalho Batista; Nelson Wolosker; Antonio Eduardo Zerati; Rita de Cassia Gengo e Silva

    2015-01-01

    AbstractOBJECTIVEOf this study were to evaluate the functional independence of patients with intermittent claudication and to verify its association with sociodemographic and clinical variables, walking ability and physical activity level.METHODThis was a descriptive, exploratory, cross-sectional study with a quantitative approach. Fifty participants (66.4 years; 68% male) were recruited from Claudication Unit of a tertiary hospital. Functional Independence Measure were used to evaluate funct...

  12. The effect-enhancing and toxicity-reducing activity of Hypericum japonicum Thunb. extract in murine liver cancer chemotherapy

    OpenAIRE

    ZHANG, HONG-BO; Lu, Ping; CAO, WEN-BO; Zhang, Zhen-Hua; MENG, XIANG-LEI

    2012-01-01

    Chinese herbs are potential sources of antitumor drugs with immunoregulatory activity and few adverse effects. In the present study, we investigated whether the Hypericum japonicum Thunb. (HJT) extract enhanced the efficacy of 5-fluorouracil (5-FU) treatment in murine liver tumor xenografts and reduced toxicity of chemotherapy in hepatoma H22-bearing mice. Tumor weight and inhibition rate, thymus and spleen indices, as well as white blood cell (WBC) count were calculated. The phagocytic funct...

  13. Iterative Mixture Component Pruning Algorithm for Gaussian Mixture PHD Filter

    OpenAIRE

    Xiaoxi Yan

    2014-01-01

    As far as the increasing number of mixture components in the Gaussian mixture PHD filter is concerned, an iterative mixture component pruning algorithm is proposed. The pruning algorithm is based on maximizing the posterior probability density of the mixture weights. The entropy distribution of the mixture weights is adopted as the prior distribution of mixture component parameters. The iterative update formulations of the mixture weights are derived by Lagrange multiplier and Lambert W funct...

  14. Efficiency of Nano QACs antibacterial treated garments

    OpenAIRE

    SAAD, Eman R.; GABR, Bahira G.

    2015-01-01

    Growth of bacteria on textiles possesses a range of unwanted negative effects; initially irritation and up to reach eczema, these are concerning the wearer, particularly, if grown bacteria are into socks or underwear; also clothes can generate unpleasant odour, stains and discoloration in the fabric, as well as reduction in fabric strength and subsequently contamination.  In the medical field, incorporating bacteria within nursing gowns can be fatal.  Aim of this paper, is to assess the funct...

  15. Functional Capacity Evaluation & Disability

    OpenAIRE

    Chen, Joseph J.

    2007-01-01

    Function, Impairment, and Disability are words in which many physicians have little interest. Most physicians are trained to deal with structure and physiology and not function and disability. The purpose of this article is to address some of the common questions that many physicians have with the use of functional capacity evaluation and disability and also to provide a unifying model that can explain the medical and societal variables in predicting disability. We will first define the funct...

  16. Physical Performance Is Associated with Executive Functioning in Older African American Women

    OpenAIRE

    Schneider, Brooke C.; Lichtenberg, Peter A.

    2011-01-01

    An older adult's ability to perform physical tasks is predictive of disability onset and is associated with declines in cognition. Risk factors for physical performance declines among African Americans, a group with the highest rates of disability, remain understudied. This study sought to identify demographic, health, and cognitive factors associated with lower-extremity physical performance in a sample of 106 African American women ages 56 to 91. After controlling for global cognitive funct...

  17. On Some Quiver Determinantal Varieties

    OpenAIRE

    Fei, Jiarui

    2014-01-01

    We introduce certain quiver analogue of the determinantal variety. We study the Kempf-Lascoux-Weyman's complex associated to a line bundle on the variety. In the case of generalized Kronecker quivers, we give a sufficient condition on when the complex resolves a maximal Cohen-Macaulay module supported on the quiver determinantal variety. This allows us to find the set-theoretical defining equations of these varieties. When the variety has codimension one, the only irreducible polynomial funct...

  18. The Value of Brownfield Remediation

    OpenAIRE

    Kevin Haninger; Lala Ma; Christopher Timmins

    2014-01-01

    The U.S. Environmental Protection Agency Brownfields Program awards grants to redevelop contaminated lands known as brownfields. This paper estimates cleanup benefits by combining administrative records for a nationally representative sample of brownfields with high-resolution, high-frequency housing data. We find property value increases accompanying cleanup averaging from 5.0% to 11.5%; for a welfare interpretation that does not rely on the intertemporal stability of the hedonic price funct...

  19. BLAP-Tags, TUBEs and DUB-Chips: Combined Novel Technologies will Advance Molecular Epithelial Physiology

    OpenAIRE

    Hamilton, Kirk L.

    2012-01-01

    The field of ubiquitylation and deubiquitylation of proteins in molecular physiology is growing at a rapid rate. Our understanding of molecular physiology of these processes may become limited by the advancement of technologies that scientists can employ. Therefore, it is important to approach physiological questions of ubiquitylation and deubiquitylation of proteins from a multiple methodological direction. Indeed, the role of ubiquitylation and deubiquitylation of proteins in cellular funct...

  20. A Parsing Mode based Method for Malformed SIP Messages Testing for IMS Network

    OpenAIRE

    Yulong Wang; Dong Wang; Lei Wang

    2013-01-01

    IMS(IP Multimedia Subsystem) network uses SIP (Session Initiation Protocol) as its core control protocol. The defensive ability of the malformed SIP message is particularly important for IMS network security. In this paper, we propose a malformed SIP generation method based on SIP parsing mode and the associated attack testing method. Based on SIP parsing mode of functional entities in IMS, we generate effective malformed SIP messages, which then be used to perform attacking test to IMS funct...

  1. Energy use and carbon footprint from lawn management : A case study in the Uppsala region of Sweden

    OpenAIRE

    Wesström, Therese

    2015-01-01

    Atmospheric concentrations of greenhouse gas emissions are now higher than ever before, with severe implications for both humans and ecosystems around the world. To mitigate climate change, large and sustained reductions of greenhouse gas emissions are required. The management of lawns entail frequent maintenance activities, such as mowing, irrigation and fertilisation, which require energy and cause greenhouse gas emissions. Lawns cover a significant part of urban areas worldwide, with funct...

  2. A Self-Adaptive Particle Swarm Optimization Based Multiple Source Localization Algorithm in Binary Sensor Networks

    OpenAIRE

    Long Cheng; Yan Wang; Shuai Li

    2015-01-01

    With the development of wireless communication and sensor techniques, source localization based on sensor network is getting more attention. However, fewer works investigate the multiple source localization for binary sensor network. In this paper, a self-adaptive particle swarm optimization based multiple source localization method is proposed. A detection model based on Neyman-Pearson criterion is introduced. Then the maximum likelihood estimator is employed to establish the objective funct...

  3. COLOR–THE ROLE OF COLOR IN PRODUCTS DESIGN PART II

    OpenAIRE

    L. D. Bordeianu; L. Hristian; I. G. Lupu

    2012-01-01

    The paper is analyzing the colors from sensorial-perceptive point of view point. The color, as one of the most important visual instruments can became a characteristic element of products, brands or company identification by using its special capabilities conveyed through technique. In trade, the color has a major role for advertising, packaging, and can and must communicate information about the quality and other characteristics of products. The principles that underlie the use and the funct...

  4. КОРПОРАТИВНО УПРАВЛЕНИЕ НА ФИНАНСОВИ ПОСРЕДНИЦИ: КОНВЕРГЕНЦИЯ И ДИВЕРГЕНЦИЯ

    OpenAIRE

    Nedelchev, Miroslav

    2012-01-01

    The paper reviews the Corporate Governance from his evolution point of view. The used perspective is a discussion between convergence and divergence in corporate governance of financial intermediaries. The discussion is core for researches in scientific and implementation papers for last fifty years. Based on “principal-agent” model the paper illustrates both the dynamics of corporate governance and contemporary points of view for convergence and divergence of systems and practices. The funct...

  5. Health considerations regarding horizontal transfer of microbial transgenes present in genetically modified crops

    OpenAIRE

    Kleter, G.A.; Peijnenburg, A.A.C.M.; Aarts, H.J.M.

    2005-01-01

    The potential effects of horizontal gene transfer on human health are an important item in the safety assessment of genetically modified organisms. Horizontal gene transfer from genetically modified crops to gut microflora most likely occurs with transgenes of microbial origin. The characteristics of microbial transgenes other than antibiotic-resistance genes in market-approved genetically modified crops are reviewed. These characteristics include the microbial source, natural function, funct...

  6. Do Improvements in Balance Relate to Improvements in Long-Distance Walking Function after Stroke?

    OpenAIRE

    Awad, Louis N.; Reisman, Darcy S.; Binder-Macleod, Stuart A.

    2014-01-01

    Stroke survivors identify a reduced capacity to walk farther distances as a factor limiting their engagement at home and in community. Previous observational studies have shown that measures of balance ability and balance self-efficacy are strong predictors of long-distance walking function after stroke. Consequently, recommendations to target balance during rehabilitation have been put forth. The purpose of this study was to determine if the changes in balance and long-distance walking funct...

  7. Subunit interactions and protein stability in the cyanobacterial light-harvesting proteins.

    OpenAIRE

    Plank, T; Toole, C; Anderson, L K

    1995-01-01

    Strain 4R is a phycocyanin-minus mutant of the unicellular cyanobacterium Synechocystis sp. strain 6803. Although it lacks the light-harvesting protein phycocyanin, 4R has normal levels of phycocyanin (cpc) transcripts. Sequence analysis of the cpcB gene encoding the phycocyanin beta subunit shows an insertion mutation in 4R that causes early termination of translation. Other work has shown that the phycocyanin alpha subunit and the linker proteins encoded on the cpc transcripts are all funct...

  8. Cognitive, behavioral, and autonomic correlates of mind wandering and perseverative cognition in major depression

    OpenAIRE

    Cristina eOttaviani; Leila eShahabi; Mika eTarvainen; Ian eCook; Michelle eAbrams; David eShapiro

    2015-01-01

    Autonomic dysregulation has been hypothesized to play a role in the relationships between psychopathology and cardiovascular risk. An important transdiagnostic factor that has been associated with autonomic dysfunction is perseverative cognition (PC), mainly present in Major Depressive Disorder (MDD) in the form of rumination. As the ability to adaptively let our mind wander (MW) without ruminating is critical to mental health, this study aimed to examine the autonomic concomitants of funct...

  9. Toward Eradicating HIV Reservoirs in the Brain: Inhibiting P-glycoprotein at the Blood-Brain Barrier with Prodrug Abacavir Dimers

    OpenAIRE

    Namanja, Hilda A.; Emmert, Dana; Davis, David A.; Campos, Christopher; Miller, David S.; Hrycyna, Christine A.; Chmielewski, Jean

    2011-01-01

    Eradication of HIV reservoirs in the brain necessitates penetration of antiviral agents across the blood-brain barrier (BBB), a process limited by drug efflux proteins such as P-glycoprotein (P-gp) at the membrane of brain capillary endothelial cells. We present an innovative chemical strategy toward the goal of therapeutic brain penetration of the P-gp substrate and anti-viral agent abacavir, in conjunction with a traceless tether. Dimeric prodrugs of abacavir were designed to have two funct...

  10. Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology

    OpenAIRE

    Holmes, Cheryl L; Landry, Donald W.; Granton, John T.

    2003-01-01

    Vasopressin is emerging as a rational therapy for vasodilatory shock states. Unlike other vasoconstrictor agents, vasopressin also has vasodilatory properties. The goal of the present review is to explore the vascular actions of vasopressin. In part 1 of the review we discuss structure, signaling pathways, and tissue distributions of the classic vasopressin receptors, namely V1 vascular, V2 renal, V3 pituitary and oxytocin receptors, and the P2 class of purinoreceptors. Knowledge of the funct...

  11. Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission

    OpenAIRE

    Zhang, Xuchen; Shan, Peiying; Homer, Robert; Zhang, Yi; Petrache, Irina; Mannam, Praveen; Lee, Patty J.

    2014-01-01

    Emphysema is characterized by loss of lung elasticity and irreversible air space enlargement, usually in the later decades of life. The molecular mechanisms of emphysema remain poorly defined. We identified a role for a novel cathepsin, cathepsin E, in promoting emphysema by inducing mitochondrial fission. Unlike previously reported cysteine cathepsins, which have been implicated in cigarette smoke-induced lung disease, cathepsin E is a nonlysosomal intracellular aspartic protease whose funct...

  12. Factors associated with depression in pediatric cancer patients, and participation of nursing in its detection

    OpenAIRE

    Sandra Velásquez-Silva; Lina Zuluaga-Sarmiento

    2015-01-01

    The objective of this work is to describe what are the factors associated with depression in pediatric patients with cancer and how nurses can participate in its detection. We conducted an integrative review of articles published between 2000 and 2012. Fifteen articles were selected and then critically analyzed and organized by subjects according to their purpose. Among factors associated with depression are the following: personal factors: adaptability, developmental level and physical funct...

  13. Assessment of Peripheral Lung Mechanics

    OpenAIRE

    Bates, Jason H. T.; Suki, Béla

    2008-01-01

    The mechanical properties of the lung periphery are major determinants of overall lung function, and can change dramatically in disease. In this review we examine the various experimental techniques that have provided data pertaining to the mechanical properties of the lung periphery, together with the mathematical models that have been used to interpret these data. These models seek to make a clear distinction between the central and peripheral compartments of the lung by encapsulating funct...

  14. Automated Techniques for Hash Function and Block Cipher Cryptanalysis (Automatische technieken voor hashfunctie- en blokcijfercryptanalyse)

    OpenAIRE

    Mouha, Nicky

    2012-01-01

    Cryptography is the study of mathematical techniques that ensure the confidentiality and integrity of information. This relatively new field started out as classified military technology, but has now become commonplace in our daily lives. Cryptography is not only used in banking cards, secure websites and electronic signatures, but also in public transport cards, car keys and garage door openers.Two building blocks in the domain of cryptography are block ciphers and (cryptographic) hash funct...

  15. Synaptic remodeling generates synchronous oscillations in the degenerated outer mouse retina

    OpenAIRE

    Wadood eHaq; Blanca eArango-Gonzalez; Eberhart eZrenner; Thomas eEuler; Timm eSchubert

    2014-01-01

    During neuronal degenerative diseases, neuronal microcircuits undergo severe structural alterations, leading to remodeling of synaptic connectivity. The functional consequences of such remodeling are mostly unknown. For instance, in mutant rd1 mouse retina, a common model for Retinitis Pigmentosa, rod bipolar cells (RBCs) establish contacts with remnant cone photoreceptors (cones) as a consequence of rod photoreceptor cell death and the resulting lack of presynaptic input. To assess the funct...

  16. Arabic Document Classification Using Multiword Features

    OpenAIRE

    Diab Abuaiadah

    2013-01-01

    Weinvestigate the use of multiword features to improve Arabic document classification. The Arabic language is both morphologically rich and highly inflected. Accordingly it presents more challenges when enhancing Arabic information retrieval to a level comparable to English. The multiword features are modeled as a combination of words appearing within windows of varying sizes. Our experiments show multiword features combined with dice similarity distance outperform the cosine similarity funct...

  17. Python library reference

    OpenAIRE

    Rossum, van, M.A.J.

    1995-01-01

    Python is an extensible, interpreted, object-oriented programming language. It supports a wide range of applications, from simple text processing scripts to interactive WWW browsers. While the Python Reference Manual describes the exact syntax and semantics of the language, it does not describe the standard library that is distributed with the language, and which greatly enhances its immediate usability. This library contains built-in modules (written in C) that provide access to system funct...

  18. Assessing Investment in Precision Farming for Reducing Pesticide Use in French Viticulture

    OpenAIRE

    Lescot, J.M.; Rousset, S.; Souville, G.

    2011-01-01

    The paper develops a mathematical programming model for assessing the impact of Environmental Policy instruments on French winegrowing farm's adoption of pesticides-saving technologies. We model choices with regards to investment in precision farming and plant protection practices, in a multi-periodic framework with sequential decision, integrating uncertainty on fungal disease pressure and imperfect information on equipment performance. We focus on recursive models maximizing a Utility funct...

  19. System solution of evaluation of the brand management’s efficiency in the competitive environment: a methodology of benchmarking

    OpenAIRE

    Kendiukhov Oleksandr Volodymyrovych

    2014-01-01

    The aim of the article. The article is based on generalization of the results of leading scientists in the brand management sphere. It is proved that using of benchmarking to assess the brand management effectiveness is the most appropriate evaluation system in current market conditions. The purpose of this article is to develop the methodology for assessing the effectiveness of brand management through benchmarking. The results of the analysis. Brand management is the most important funct...

  20. (Re-)Construction, characterization and modeling of genomes for synthetic biology

    OpenAIRE

    Suarez Diez, Maria; Lam, Carolyn; Leprince, Audrey; Martins Dos Santos, Vitor

    2009-01-01

    Abstract Synthetic biology is the rational (re-)design of biological systems with useful properties. In its engineering perspective, it aims at transforming biotechnology into a true engineering discipline with the corresponding reliabilities and accuracies in design. Under this view, the building blocks of complex systems are well-characterized biological modules, designed and optimized for specific functions that can be assembled into circuits to perform complex biological funct...

  1. Animal models of attention-deficit hyperactivity disorder

    OpenAIRE

    Sagvolden Terje; Russell Vivienne A; Johansen Espen

    2005-01-01

    Abstract Although animals cannot be used to study complex human behaviour such as language, they do have similar basic functions. In fact, human disorders that have animal models are better understood than disorders that do not. ADHD is a heterogeneous disorder. The relatively simple nervous systems of rodent models have enabled identification of neurobiological changes that underlie certain aspects of ADHD behaviour. Several animal models of ADHD suggest that the dopaminergic system is funct...

  2. Simulation study of a gramicidin/lipid bilayer system in excess water and lipid. I. Structure of the molecular complex.

    OpenAIRE

    Chiu, S. W.; Subramaniam, S.; Jakobsson, E.

    1999-01-01

    This paper reports on a simulation of a gramicidin channel inserted into a fluid phase DMPC bilayer with 100 lipid molecules. Two lipid molecules per leaflet were removed to insert the gramicidin, so the resulting preparation had 96 lipid molecules and 3209 water molecules. Constant surface tension boundary conditions were employed. Like previous simulations with a lower lipid/gramicidin ratio (Woolf, T. B., and B. Roux. 1996. Proteins: Struct., Funct., Genet. 24:92-114), it is found that try...

  3. Saturated- and n-6 Polyunsaturated-Fat Diets Each Induce Ceramide Accumulation in Mouse Skeletal Muscle: Reversal and Improvement of Glucose Tolerance by Lipid Metabolism Inhibitors

    OpenAIRE

    Frangioudakis, G.; J. Garrard; Raddatz, K.; Nadler, J L; Mitchell, T. W.; Schmitz-Peiffer, C.

    2010-01-01

    Lipid-induced insulin resistance is associated with intracellular accumulation of inhibitory intermediates depending on the prevalent fatty acid (FA) species. In cultured myotubes, ceramide and phosphatidic acid (PA) mediate the effects of the saturated FA palmitate and the unsaturated FA linoleate, respectively. We hypothesized that myriocin (MYR), an inhibitor of de novo ceramide synthesis, would protect against glucose intolerance in saturated fat-fed mice, while lisofylline (LSF), a funct...

  4. Stochastic Differential Equation Methods for Spatio-Temporal Gaussian Process Regression

    OpenAIRE

    Solin, Arno

    2016-01-01

    Gaussian processes (GPs) are widely used tools for non-parametric probabilistic modelling in machine learning, spatial statistics, and signal processing. Their strength lies in flexible model specification, where prior beliefs of the model functions are encoded by the GP model. This way they can also be interpreted as specifying a probability distribution over the space of functions. In signal processing GPs are typically represented as state-space models, whereas the kernel (covariance funct...

  5. Gene expression profiling analysis contributes to understanding the association between non-syndromic cleft lip and palate, and cancer

    OpenAIRE

    WANG, HONGYI; Qiu, Tao; Shi, Jie; LIANG, JIULONG; Wang, Yang; QUAN, LIANGLIANG; Zhang, Yu; Zhang, Qian; Tao, Kai

    2016-01-01

    The present study aimed to investigate the molecular mechanisms underlying non-syndromic cleft lip, with or without cleft palate (NSCL/P), and the association between this disease and cancer. The GSE42589 data set was downloaded from the Gene Expression Omnibus database, and contained seven dental pulp stem cell samples from children with NSCL/P in the exfoliation period, and six controls. Differentially expressed genes (DEGs) were screened using the RankProd method, and their potential funct...

  6. A characterization of Poisson-Gaussian families by generalized variance

    OpenAIRE

    Kokonendji, Célestin C.; Masmoudi, Afif

    2006-01-01

    We show that if the generalized variance of an infinitely divisible natural exponential family [math] in a [math] -dimensional linear space is of the form [math] , then there exists [math] in [math] such that [math] is a product of [math] univariate Poisson and ( [math] )-variate Gaussian families. In proving this fact, we use a suitable representation of the generalized variance as a Laplace transform and the result, due to Jörgens, Calabi and Pogorelov, that any strictly convex smooth funct...

  7. Zhodnocení současného stavu protierozních opatření na zemědělské půdě v katastrálním území Blansko

    OpenAIRE

    Navrátilová, Simona

    2011-01-01

    Due to the transition to agriculture, the landscape has changed significantly and the creation of a large cultivated field became the site, where rapid soil erosion occurs. In the Czech Republic, as well as in many other countries, the phenomenon of consumer society and profit maximization leads to greater and greater depletion of soil. It is therefore important to follow certain rules in the cultivation of crops and take anti-erosion measures for preventing the loss of arable land. The funct...

  8. Energy from Waste: Generation Potential and Mitigation Opportunity

    OpenAIRE

    Bosello, Francesco; Campagnolo, Lorenza; Eboli, Fabio; Parrado, Ramiro

    2014-01-01

    The present research proposes a macroeconomic assessment of the role of waste incineration with energy recovery (WtE) and controlled landfill biogas to electricity generation and their potential contribution to a CO2 emission reduction policy, within a recursive-dynamic computable general equilibrium model. From the modelling viewpoint, introducing these energy sectors in such a framework required both the extension of the GTAP7 database and the improvement of the ICES production nested funct...

  9. Methodology of a Modern Foreign Language Lesson for Postgraduate Students of Technical Disciplines

    OpenAIRE

    Olga Toporkova; Elena Novozhenina; Tamara Tchechet; Tatiana Likhacheva

    2014-01-01

    The integration of Russia into the international common space of research and education accompanied by modernization of the national system of education puts forward new demands to postgraduate education. The processes of integration and modernization increase the importance of learning a foreign language for a future scientist. The article deals with the methodological content of a foreign language lesson, the components of which are individualization, speech orientation, situatedness, funct...

  10. The Administrative and Economical Role of the Romanian State from the Perspective of the Integration in the European Union. The Economic Convergence and the Introduction of Euro Currency

    OpenAIRE

    Dumitrescu, Cristian

    2012-01-01

    The state is a unique institution, placed above all others organizational forms of the society. In order to exist, the state must meet three indispensable elements: territory, population and Government, which means that the state is defined as a human collectivity, permanently set on a certain territory and having a structure of sovereign institutions. The role of the state as the main institution which provides the organizational and political steer of the society is ensured by certain funct...

  11. A platform for dynamic simulation and control of movement based on OpenSim and MATLAB

    OpenAIRE

    Mansouri, Misagh; Reinbolt, Jeffrey A.

    2012-01-01

    Numerical simulations play an important role in solving complex engineering problems and have the potential to revolutionize medical decision making and treatment strategies. In this paper, we combine the rapid model-based design, control systems and powerful numerical method strengths of MATLAB/Simulink with the simulation and human movement dynamics strengths of OpenSim by developing a new interface between the two software tools. OpenSim is integrated with Simulink using the MATLAB S-funct...

  12. Infall of planetesimals onto growing giant planets: onset of runaway gas accretion and metallicity of their gas envelopes

    OpenAIRE

    Shiraishi, Masakazu; Ida, Shigeru

    2008-01-01

    We have investigated the planetesimal accretion rate onto giant planets that are growing through gas accretion, using numerical simulations and analytical arguments. We derived the condition for gap opening in the planetesimal disk, which is determined by a competition between the expansion of the planet's Hill radius due to the planet growth and the damping of planetesimal eccentricity due to gas drag. We also derived the semi-analytical formula for the planetesimal accretion rate as a funct...

  13. Semaphorin 3A Suppresses Tumor Growth and Metastasis in Mice Melanoma Model

    OpenAIRE

    Chakraborty, Goutam; Kumar, Santosh; Mishra, Rosalin; Tushar V Patil; Kundu, Gopal C.

    2012-01-01

    Background Recent understanding on cancer therapy indicated that targeting metastatic signature or angiogenic switch could be a promising and rational approach to combat cancer. Advancement in cancer research has demonstrated the potential role of various tumor suppressor proteins in inhibition of cancer progression. Current studies have shown that axonal sprouting inhibitor, semaphorin 3A (Sema 3A) acts as a potent suppressor of tumor angiogenesis in various cancer models. However, the funct...

  14. CARBON NANOTUBES AND PHARMACEUTICAL APPLICATIONS

    OpenAIRE

    Ram Pavani; Kodithyala Vinay

    2011-01-01

    Carbon nanotubes (CNTs) are often described as a graphene sheet rolled up into the shape of a cylinder. These have fascinated scientists with their extraordinary properties. These compounds have become increasingly popular in various fields simply because of their small size and amazing optical, electric and magnetic properties when used alone or with additions of metals. Carbon nanotubes have potential therapeutic applications in the field of drug delivery, diagnostics, and biosensing. Funct...

  15. Managing a South African organisation within a dual manufacturing and services economy

    OpenAIRE

    Weeks, R; S. Benade

    2008-01-01

    Purpose: The purpose of this paper is to analyse the nature of the South African dual manufacturing and services economy and the impact thereof on organisations from a management perspective. Problem investigated: Services account for over 65% of South Africa's gross domestic product (GDP) and reflects an escalating trend. The manufacturing sector of the economy is just over 26% of GDP. This by implication implies that the South African economy is dualistic in nature. The economy funct...

  16. Protein target discovery of drug and its reactive intermediate metabolite by using proteomic strategy

    OpenAIRE

    Lianghai Hu; John Paul Fawcett; Jingkai Gu

    2012-01-01

    Identifying protein targets of bioactive compounds is an effective approach to discover unknown protein functions, identify molecular mechanisms of drug action, and obtain information for optimization of lead compounds. At the same time, metabolic activation of a drug can lead to cytotoxicities. Therefore, it is very important to systemically characterize the drug and its reactive intermediate. Mass spectrometry-based proteomic approach has emerged as the most efficient to study protein funct...

  17. Effects of task-oriented training on upper extremity function and performance of daily activities in chronic stroke patients with impaired cognition

    OpenAIRE

    Park, Juhyung

    2016-01-01

    [Purpose] This study aimed to determine the effects of task-oriented training on upper extremity function and performance of daily activities in chronic stroke patients with impaired cognition. [Subjects and Methods] In this study, 2 chronic hemiplegic stroke patients underwent task-oriented training. The training was conducted once a day for 30 minutes, 5 times/week, for 2 weeks. The patients were evaluated 3 times before and after the task-oriented training. Changes in upper extremity funct...

  18. The Complexity of Generalized Satisfiability for Linear Temporal Logic

    OpenAIRE

    Bauland, Michael; Schneider, Thomas; Schnoor, Henning; Schnoor, Ilka; Vollmer, Heribert

    2008-01-01

    In a seminal paper from 1985, Sistla and Clarke showed that satisfiability for Linear Temporal Logic (LTL) is either NP-complete or PSPACE-complete, depending on the set of temporal operators used. If, in contrast, the set of propositional operators is restricted, the complexity may decrease. This paper undertakes a systematic study of satisfiability for LTL formulae over restricted sets of propositional and temporal operators. Since every propositional operator corresponds to a Boolean funct...

  19. Big Data Offers Novel Insights for Oncolytic Virus Immunotherapy

    OpenAIRE

    Swift, Stephanie L.; Stojdl, David F

    2016-01-01

    Large-scale assays, such as microarrays, next-generation sequencing and various “omics” technologies, have explored multiple aspects of the immune response following virus infection, often from a public health perspective. Yet a lack of similar data exists for monitoring immune engagement during oncolytic virus immunotherapy (OVIT) in the cancer setting. Tracking immune signatures at the tumour site can create a snapshot or longitudinally analyse immune cell activation, infiltration and funct...

  20. Sırrı Paşa (Fidangör) Yaya Bölgesinin Engelli Kullanımı Açısından Ulaşılabilirliğinin Değerlendirilmesi

    OpenAIRE

    Akbaş, Hazal Bengühan; Atabeyoğlu, Ömer

    2015-01-01

    ABSCART The people need to opportunity of harboring, education, working, social, cultural and recreation. These opportunities have attainableness for all people that are using to same living spaces. The design is appropriate, when the living environments have equal opportunities for all people. Disability hasn't some abilities as physical and sensorial. Disabled people come across many factors that restrict to use urban functions. The attainableness provides to use maximum to urban funct...

  1. Cognitive and Academic Outcomes after Pediatric Liver Transplantation: Functional Outcomes Group (FOG) Results

    OpenAIRE

    Sorensen, L.G.; Neighbors, K.; Martz, K.; Zelko, F.; Bucuvalas, J.C.; Alonso, E. M.

    2011-01-01

    This multi-center study examined prevalence of cognitive and academic delays in children following liver transplant (LT). 144 patients ages 5–7 and 2 years post-LT were recruited through the SPLIT consortium and administered the Wechsler Preschool and Primary Scale of Intelligence, 3rd Edition (WPPSI-III), the Bracken Basic Concept Scale, Revised (BBCS-R), and the Wide Range Achievement Test, 4th edition (WRAT-4). Parents and teachers completed the Behavior Rating Inventory of Executive Funct...

  2. Continuous variable teleportation as a generalized thermalizing quantum channel

    OpenAIRE

    Ban, Masashi; Sasaki, Masahide; Takeoka, Masahiro

    2002-01-01

    A quantum channel is derived for continuous variable teleportation which is performed by means of an arbitrary entangled state and the standard protocol. When a Gaussian entangled state such as a two-mode squeezed-vacuum state is used, the continuous variable teleportation is equivalent to the thermalizing quantum channel. Continuous variable dense coding is also considered. Both the continuous variable teleportation and the continuous variable dense coding are characterized by the same funct...

  3. COMPLEX DYNAMICS OF ONE-PREY MULTI-PREDATOR SYSTEM WITH DEFENSIVE ABILITY OF PREY AND IMPULSIVE BIOLOGICAL CONTROL ON PREDATORS

    OpenAIRE

    YONGZHEN PEI; CHANGGUO LI; LANSUN CHEN; CHUNHUA WANG

    2005-01-01

    This work investigates the dynamic behaviors of one-prey multi-predator model with defensive ability of the prey by introducing impulsive biological control strategy. By using the Floquent theorem and the small amplitude perturbation method, it is proved that there exists an asymptotically stable pest-eradication periodic solution when the impulsive period is less than some critical value, and a permanence condition is established via the method of comparison involving multiple Liapunov funct...

  4. Effect of a high-intensity exercise program on physical function and mental health in nursing home residents with dementia: An assessor blinded randomized controlled trial

    OpenAIRE

    Elisabeth Wiken Telenius; Knut Engedal; Astrid Bergland

    2016-01-01

    Background Dementia is among the leading causes of functional loss and disability in older adults. Research has demonstrated that nursing home patients without dementia can improve their function in activities of daily living, strength, balance and mental well being by physical exercise. The evidence on effect of physical exercise among nursing home patients with dementia is scarce and ambiguous. Thus, the primary objective of this study was to investigate the effect of a high intensity funct...

  5. Cerebral White Matter Integrity and Resting-State Functional Connectivity in Middle-aged Patients With Type 2 Diabetes

    OpenAIRE

    Hoogenboom, Wouter S.; Marder, Thomas J.; Flores, Veronica L.; Huisman, Susanne; Eaton, Hana P.; Schneiderman, Jason S.; Bolo, Nicolas R.; Simonson, Donald C.; Jacobson, Alan M.; Kubicki, Marek; Martha E. Shenton; Musen, Gail

    2014-01-01

    Early detection of brain abnormalities at the preclinical stage can be useful for developing preventive interventions to abate cognitive decline. We examined whether middle-aged type 2 diabetic patients show reduced white matter integrity in fiber tracts important for cognition and whether this abnormality is related to preestablished altered resting-state functional connectivity in the default mode network (DMN). Diabetic and nondiabetic participants underwent diffusion tensor imaging, funct...

  6. Determining the Administrative Support and Professional Development Needs of Contract Instructors at a Civilian Federal Training Agency.

    OpenAIRE

    Saitta, Joseph V. Jr.

    1998-01-01

    Researchers know much about the use of contract (or adjunct) instructor faculty in academe, but little about contract instructors in civilian federal training agencies. No one has determined the effective administrative support of instructional delivery or the professional development needs of these federal agency contractors. The National Fire Academy's mission is to promote the professional development of those fire personnel engaged in fire suppression, fire prevention, and allied funct...

  7. Phase contrast image synthesis

    DEFF Research Database (Denmark)

    Glückstad, J.

    A new method is presented for synthesizing arbitrary intensity patterns based on phase contrast imaging. The concept is grounded on an extension of the Zernike phase contrast method into the domain of full range [0; 2 pi] phase modulation. By controlling the average value of the input phase funct...... function and by choosing appropriate phase retardation at the phase contrast filter, a pure phase to intensity imaging is accomplished. The method presented is also directly applicable in dark field image synthesis....

  8. α-Synuclein and Mitochondria: Partners in Crime?

    OpenAIRE

    Nakamura, Ken

    2013-01-01

    Increased α-synuclein levels and mutations in mitochondria-associated proteins both cause familial Parkinson’s disease (PD), and synuclein and mitochondria also play central, but poorly understood, roles in the pathogenesis of idiopathic PD. A fraction of synuclein interacts with mitochondria, and synuclein can produce mitochondrial fragmentation and impair mitochondrial complex I activity. However, the consequences of these mitochondrial changes for bioenergetic and other mitochondrial funct...

  9. Hepatic and Renal Disfunction After Using Lavandula Stoechas and Melissa Officinalis Herbal

    Directory of Open Access Journals (Sweden)

    Sami BAHÇEBAŞI

    2011-05-01

    Full Text Available Toxic nephropathies are one of the important and common cause of renal injury mechanisms. Although they are generally reversible when diagnosed at early stage, sometimes result in chronic kidney disease (CKD.Toxic nepropathies are caused by drugs, diagnosing agents, chemicals and environmental agents. We here report a patient had impaired liver and renal functıons due to exposure to lavandula stoechas and melissa tea which has not been in the literature yet.

  10. Shortness of Breath and Lower Limb Edema in a 54-Year-Old Woman, Is There Any Cure?

    OpenAIRE

    Frogoudaki, Alexandra; S. Triantafyllis, Andreas; Vassilatou, Evangeline; Tsamakis, Charalampos; Zacharoulis, Achilles; Lekakis, John

    2015-01-01

    Introduction: Pulmonary hypertension is common among patients with hyperthyroidism, and Graves’ disease constitutes the most common cause of thyrotoxicosis. Case Presentation: We report the case of a female patient admitted to the cardiology department with shortness of breath and pretibial myxedema. The diagnostic work-up revealed combined pre- and post-capillary pulmonary hypertension due to Graves’ disease superimposed on left ventricular diastolic dysfunction. Restoration of thyroid funct...

  11. Un Sistema vegetato per la biorimediation di un suolo inquinato da metalli pesanti e idrocarburi: "Il caso di Madonna dell'Acqua in Toscana"

    OpenAIRE

    Manca, Agata

    2009-01-01

    This work is a part of a project carried out by CNR-ISE – Pisa, in collaboration with S. Giuliano Terme (Pisa) Municipality. Aim of the project was to test and apply bioremediation techniques to a heavy metal and hydrocarbon contaminated site (Madonna dell’Acqua, Tuscany). The bioremediation system studied included the use of plants, earthworms and organic matter. The final objectives were dual: decontamination and biophysical regeneration of soil in order to recover its ecological funct...

  12. Influence of Grazing Intensity on Soil Properties and Shaping Herbaceous Plant Communities in Semi-Arid Dambo Wetlands of Zimbabwe

    OpenAIRE

    E. Dahwa; C. P. Mudzengi; Hungwe, T.; M. D. Shoko; Poshiwa, X.; Kativu, S.; C. Murungweni

    2013-01-01

    Key issues of concern regarding the environmental impacts of livestock on grazing land are their effects on soil, water quality, and biodiversity. This study was carried out to determine how grazing intensity influences soil physical and chemical properties and occurrence of herbaceous plant species in dambo wetlands. Three categories of grazing intensity were selected from communal, small scale commercial and large scale commercial land. Dambos from the large scale commercial land funct...

  13. Catechol-O-Methyltransferase (COMT) Val 108/158 Met polymorphism does not modulate executive function in children with ADHD

    OpenAIRE

    Stepanian Marina; Torkaman-Zehi Adam; Deguzman Rosherie; Mbekou Valentin; Lageix Philippe; Amor Leila; Grizenko Natalie; Taerk Evan; Baron Chantal; Joober Ridha

    2004-01-01

    Abstract Background An association has been observed between the catechol-O-methyltransferase (COMT) gene, the predominant means of catecholamine catabolism within the prefrontal cortex (PFC), and neuropsychological task performance in healthy and schizophrenic adults. Since several of the cognitive functions typically deficient in children with Attention Deficit Hyperactivity Disorder (ADHD) are mediated by prefrontal dopamine (DA) mechanisms, we investigated the relationship between a funct...

  14. Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest

    OpenAIRE

    Tunbridge, Elizabeth M.; Farrell, Sarah M.; Harrison, Paul J; Mackay, Clare E

    2013-01-01

    Catechol-O-methyltransferase (COMT) modulates dopamine in the prefrontal cortex (PFC) and influences PFC dopamine-dependent cognitive task performance. A human COMT polymorphism (Val158Met) alters enzyme activity and is associated with both the activation and functional connectivity of the PFC during task performance, particularly working memory. Here, we used functional magnetic resonance imaging and a data-driven, independent components analysis (ICA) approach to compare resting state funct...

  15. Molecular determinants of regulatory T cell development: the essential roles of epigenetic changes

    OpenAIRE

    Yohko eKitagawa; Naganari eOhkura; Shimon eSakaguchi

    2013-01-01

    Regulatory T (Treg) cells constitute a distinct T cell subset, which plays a key role in immune tolerance and homeostasis. The transcription factor Foxp3 controls a substantial part of Treg cell development and function. Yet its expression alone is insufficient for conferring developmental and functional characteristics of Treg cells. There is accumulating evidence that concurrent induction of Treg-specific epigenetic changes and Foxp3 expression is crucial for lineage specification and funct...

  16. Long-Term Low-Level Arsenic Exposure Is Associated with Poorer Neuropsychological Functioning: A Project FRONTIER Study

    OpenAIRE

    Sid E. O’Bryant; Edwards, Melissa; Chloe V. Menon; Gong, Gordon; Barber, Robert

    2011-01-01

    Exposure to elements in groundwater (toxic or beneficial) is commonplace yet, outside of lead and mercury, little research has examined the impact of many commonly occurring environmental exposures on mental abilities during the aging process. Inorganic arsenic is a known neurotoxin that has both neurodevelopmental and neurocognitive consequences. The aim of this study was to examine the potential association between current and long-term arsenic exposure and detailed neuropsychological funct...

  17. A cucurbit androecy gene reveals how unisexual flowers develop and dioecy emerges

    OpenAIRE

    Boualem, Adnane; Troadec, Christelle; Camps, Céline; Lemhemdi, Afef; Morin, Halima; Sari, Marie-Agnès; Fraenkel-Zagouri, Rina; Kovalski, Irina; Dogimont, Catherine; Perl-Treves, Rafael

    2015-01-01

    Understanding the evolution of sex determination in plants requires identifying the mechanisms underlying the transition from monoecious plants, where male and female flowers coexist, to unisexual individuals found in dioecious species. We show that in melon and cucumber, the androecy gene controls female flower development and encodes a limiting enzyme of ethylene biosynthesis, ACS11. ACS11 is expressed in phloem cells connected to flowers programmed to become female, and ACS11 loss-of-funct...

  18. Altitudinal differences in flower traits and reproductive allocation

    OpenAIRE

    Fabbro, Thomas; Körner, Christian

    2005-01-01

    We tested whether alpine plants increase their effort to attract pollinators to compensate for assumed pollinator scarcity at high altitude. A three times larger fraction of the shoot was allocated to flowers in alpine plants (30 species, 2700m asl) compared to lowland plants (20 species, 600m asl), while leaf mass fraction did not differ between the altitudes. At high elevation, a three times smaller fraction of the shoot was allocated to stems, which was accompanied by a change in its funct...

  19. The state of strategic human resource measurement in Spanish banks

    OpenAIRE

    Cabrera, Elizabeth F.; Cabrera, Ángel

    1999-01-01

    The new strategic role of Human Resource (HR) management that many academics and practitioners have been calling for requires that HR systems not only achieve operational excellence in performing their traditional activities but that they also contribute to developing the strategic capabilities needed by the organization to maintain its competitive advantage. This new orientation has important implications for the evaluation of an organization's HR system. Traditional measures of the HR funct...

  20. Flipped parameter technique applied on source localization in energy constraint sensor arrays

    OpenAIRE

    Pavlović Vlastimir D.; Veličković Zoran S.

    2009-01-01

    In this paper novel flipped parameter technique (FPT) for time delay estimation (TDE) in source localization problem is described. We propose passive source localization technique based on the development of an energy efficient algorithm that can reduce intersensor and interarray communication. We propose a flipped parameter (FP) which can be defined for any sensor in distributed sensor subarrays during the observation period. Unlike classical TDE methods that evaluate cross-correlation funct...

  1. An Improved Marriage in Honey Bees Optimization Algorithm for Single Objective Unconstrained Optimization

    OpenAIRE

    Yuksel Celik; Erkan Ulker

    2013-01-01

    Marriage in honey bees optimization (MBO) is a metaheuristic optimization algorithm developed by inspiration of the mating and fertilization process of honey bees and is a kind of swarm intelligence optimizations. In this study we propose improved marriage in honey bees optimization (IMBO) by adding Levy flight algorithm for queen mating flight and neighboring for worker drone improving. The IMBO algorithm's performance and its success are tested on the well-known six unconstrained test funct...

  2. What do older people understand by mobility-related difficulties?

    OpenAIRE

    Ramos Pichardo, Juan Diego; Cabrero García, Julio; González Llopis, Lorena; Cabañero Martínez, María José; Muñoz Mendoza, Carmen Luz; Sanjuán Quiles, Ángela; Richart Martínez, Miguel; Reig Ferrer, Abilio

    2014-01-01

    Despite the centrality of the difficulty concept in the study of disability, there has been little research on its significance from the point of view of people with functional limitations. The main objective of this study was to describe what older people understand when asked about difficulty in undertaking mobility activities. As a secondary objective, we considered whether there are any differences depending on the type of activities, according to the International Classification of Funct...

  3. Multi-channel tunable source for atomic sensors Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR will establish the feasibility of developing compact, robust, integrated components suitable for atomic interferometry. AdvR's design is enabled...

  4. Direct solid-phase radioimmunoassay for the detection of Aujeszky's disease antibodies

    International Nuclear Information System (INIS)

    A direct solid-phase radioimmunoassy (dRIA) was developed in order to demonstrate antibodies against Aujeszky's disease virus (ADV) in sera obtained from pigs and rabbits. In the presence of guinea-pig complement the above test is 160-fold to 1500-fold more sensitive than the neutralization test (NT) and 320-fold to 150 000-fold more sensitive than sera obtained from an ADV-infected farm, which were found to be negative in the complement assisted NT. It is possible to test a single dilution of unknown serum by dRIA by comparing same with a standard curve and to make a statement regarding its ADV-specific binding capacity to 125I-labelled ADV antigen. The advantages of dRIA in comparison to the indirect RIA and the advantages and disadvantages with regard to ELISA were discussed. (orig.)

  5. Checking the Goldbach conjecture on a vector computer

    NARCIS (Netherlands)

    Granville, A.; Lune, J. van de; Riele, H.J.J. te

    1989-01-01

    bibliographical data to be processed -- Number theory and applications (Banff, AB, 1988) Pages: 423--433 Series: NATO Adv. Sci. Inst. Ser. C Math. Phys. Sci. Vol: 265 -- Kluwer Acad. Publ. (Dordrecht) -- 10

  6. Disease: H00594 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available pathogenesis of distal muscular dystrophies. Adv Exp Med Biol 652:23-38 (2009) PMID:17029922 (gene, description) Udd B Molecular biol...ogy of distal muscular dystrophies--sarcomeric proteins on top. Biochim Biophys Act

  7. High Fidelity Down-Conversion Source for Secure Communications using On-Demand Single Photons Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this NASA SBIR Phase II effort, AdvR will design and build an efficient, fully integrated, waveguide based, source of spectrally uncorrelated photon pairs that...

  8. Highly Efficient, Compact, Wavelength Converters for Pulsed and CW Laser Sources Used in Lidar-Based Remote Sensing and Ranging Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — AdvR, Inc. proposes the development of a highly efficient, fiber pigtailed, waveguide-based UV frequency converter module. This UV module will be an important...

  9. Ridge Waveguide Structures in Magnesium-Doped Lithium Niobate Project

    Data.gov (United States)

    National Aeronautics and Space Administration — AdvR, Inc. proposes the development of an efficient process for fabricating ridge waveguides in magnesium-doped lithium niobate (MgO:LN). The effort will include,...

  10. Neutrophil surface adhesion molecule and toll like receptor dynamics in crossbred cows suffering from Staphylococcus aureus subclinical and clinical mastitis

    Directory of Open Access Journals (Sweden)

    Dilip Kumar Swain

    2016-06-01

    Conclusion: Host elicits stage specific expression of surface adhesion molecules and TLR2 and TLR4 as dynamic host innate immune response against Staphylococcal mastitis. [J Adv Vet Anim Res 2016; 3(2.000: 99-105

  11. Photovoltage versus microprobe sheet resistance measurements on ultrashallow structures

    DEFF Research Database (Denmark)

    Clarysse, T.; Moussa, A.; Parmentier, B.;

    2010-01-01

    Earlier work [T. Clarysse , Mater. Sci. Eng., B 114-115, 166 (2004); T. Clarysse , Mater. Res. Soc. Symp. Proc. 912, 197 (2006)] has shown that only few contemporary tools are able to measure reliably (within the international technology roadmap for semiconductors specifications) sheet resistances...... on ultrashallow (sub-50-nm) chemical-vapor-deposited layers [T. Clarysse , Mater. Res. Soc. Symp. Proc. 912, 197 (2006)], especially in the presence of medium/highly doped underlying layers (representative for well/halo implants). Here the authors examine more closely the sheet resistance anomalies...

  12. Degradação da matéria seca e da proteína bruta de silagens de milho sem espigas com cana-de-açúcar e bagaço de mandioca - DOI: 10.4025/actascianimsci.v28i4.605 Dry mater and crude protein ruminal degradation of corn silage without spikes with sugar cane and manioc pulp - DOI: 10.4025/actascianimsci.v28i4.605

    OpenAIRE

    Paulo Rossi Junior; Carlos Ricardo Soccol; Nina Waszczynskyj; Marcos Elias Traad da Silva; Leandro Cavalcante Lipinski

    2006-01-01

    A degradação ruminal da matéria seca (MS) e da proteína bruta (PB) de silagen s de milho sem espigas (SMSE) com cana -de-açúcar (CA) e bagaço seco de mandioca (BSM), comparadas com a silagem de milho com espigas (SMCE), foi avaliada. A ensilagem foi feita com (CI) e sem inoculante (SI) - Lactobacillus plantarum e L paracasei ssp. paracasei. Estudaram-se: as frações solúvel (A), potencialmente degradável (B) e não degradável (C); a taxa de degradação da fração B (c); a degradabilidade efetiva ...

  13. Degradação da matéria seca e da proteína bruta de silagens de milho sem espigas com cana-de-açúcar e bagaço de mandioca - DOI: 10.4025/actascianimsci.v28i4.605 Dry mater and crude protein ruminal degradation of corn silage without spikes with sugar cane and manioc pulp - DOI: 10.4025/actascianimsci.v28i4.605

    Directory of Open Access Journals (Sweden)

    Paulo Rossi Junior

    2006-02-01

    Full Text Available A degradação ruminal da matéria seca (MS e da proteína bruta (PB de silagen s de milho sem espigas (SMSE com cana -de-açúcar (CA e bagaço seco de mandioca (BSM, comparadas com a silagem de milho com espigas (SMCE, foi avaliada. A ensilagem foi feita com (CI e sem inoculante (SI - Lactobacillus plantarum e L paracasei ssp. paracasei. Estudaram-se: as frações solúvel (A, potencialmente degradável (B e não degradável (C; a taxa de degradação da fração B (c; a degradabilidade efetiva (DE e potencial (DP, para os tratamentos: T1 (SMSE+20% CA -SI; T2 (SMSE+20% CA -CI; T3 (SMSE+35% CASI; T4 (SMSE+35% CA-CI; T5 (SMSE+20% BSM-SI; T6 (SMSE+20% BSM-CI; T7 (SMSE+35% BSM-SI; T8 (SMSE+35% BSM-CI; T9 (SMCE-SI e T10 (SMCE-CI. As médias foram comparadas num delineamento inteiramente casualisado. Houve diferença (P0,05. A adição de BSM (20 e 35% às SMSE aumentou (PThe goal of this work was to evaluate the ruminal degradation of corn silages without spikes (CSWS, added with sugar cane (SC and dry manioc pulp (DMP, as compared as corn silage (CS. The foods were ensiled with (WI and without (IF inoculant’s, composed by Lactobacillus plantarum and L. paracasei ssp. paracasei. The following fractions have been studied: water soluble (A, potentially degradable (B, non degradable (C, fraction B degradable ratio (c; effective (ED and potential (PD degradability. The treatments evaluated were: T1 (CSWS + 20% SC -IF; T2 (CSWS + 20% SC-WI; T3 (CSWS + 35% SC -IF; T4 (CSWS + 35% SC -WI; T5 (CSWS + 20% DMP-IF; T6 (CSWS + 20% DMP -WI; T7 (CSWS + 35% DMP -IF; T8 (CSWS + 35% DMP-WI; T9 (CS-WI and T10 (CS-IF. The average differences have been compared on a completely randomized model. Difference (P 0.05 for all treatments. Dry manioc pulp added to the non spikes corn silage (20 and 35% - DM basis, has allowed the rise of the DM fraction B, indicating the possibility to add up to 35% of dry manioc pulp on corn silage, inst ead of green spikes.

  14. Promoting the demoted

    DEFF Research Database (Denmark)

    Jensen, Torben Juel; Christensen, Tanya Karoli

    2013-01-01

    In this article, we investigate a hypothesis regarding the distinction between the word orders ‘finite verb, adverb’ (V>Adv, in Scandinavian linguistics often considered an instance of V2, also in subject initial clauses) and ‘adverb, finite verb’ (Adv>V, sometimes referred to as V3) in Mainland ...... seemingly in conflict with predictions of the semantico-pragmatic hypothesis are discussed with respect to possible norm conflicts and shifts in communicative strategy during speech production....

  15. Association of Human Adenovirus-36 With Dyslipidemia in Tehranian Children and Adolescent; TLGS

    Directory of Open Access Journals (Sweden)

    Zarkesh

    2015-04-01

    Full Text Available Background The human adenovirus-36 (Adv36 has been associated with obesity and lipid disorders in some countries. The primary dyslipidemia related to obesity is characterized by increased TG, decreased HDL levels and abnormal LDL composition. Childhood obesity is a major public health problem in most developing countries. Objectives The aim of this study was to investigate the association between Adv36 and lipid disorders in Tehranian youth. Patients and Methods In a cross-section/observational study, anthropometric, blood pressure and biochemical measurements were examined in 54 youth, aged below 19 years, selected randomly from participants of Tehran Lipid and Glucose Study (TLGS of Iran. Human Adv36 antibody of serum was determined using ELISA method. Results Of 54 youth, with a mean age of 14.78 ± 2.62 years, 85.2% were Adv36 seropositive (N = 46 and 14.8% were seronegative (N = 8. Subjects with Adv36 seropositive had higher mean of age, weight, TC, LDL-C, TG and SBP and lower level of HDL-C, waist, FBS and DBP. The unadjusted OR for elevated TG increased in participants who were Adv36 seropositive (OR 3.062, 95% CI: 0.344-27.293. Although the unadjusted OR for other lipid variables, such as elevated TC and LDL-C or decreased HDL-C, tended to increase in participants who were Adv36 seropositive (OR 1.028, 95% CI: 0.996 - 1.060; OR 1.057, 95% CI: 0.107 - 10.481; OR 1.125, 95% CI: 0.238 - 5.325, respectively, the results were not significant. Conclusions It seems that seropositive Adv36 has a strong association with lipid disorders, especially elevated TG level in Tehranian children and adolescent.

  16. Association of Human Adenovirus-36 With Dyslipidemia in Tehranian Children and Adolescent; TLGS

    OpenAIRE

    Zarkesh; Sadat Daneshpour; Ehsandar; Bandehpour; Alfadhli; Azizi; Hedayati

    2015-01-01

    Background The human adenovirus-36 (Adv36) has been associated with obesity and lipid disorders in some countries. The primary dyslipidemia related to obesity is characterized by increased TG, decreased HDL levels and abnormal LDL composition. Childhood obesity is a major public health problem in most developing countries. Objectives The aim of this study was to investigate the association between Adv36 and lipid disorders in Tehr...

  17. Measuring Turbulence from Moored Acoustic Doppler Velocimeters. A Manual to Quantifying Inflow at Tidal Energy Sites

    Energy Technology Data Exchange (ETDEWEB)

    Kilcher, Levi [National Renewable Energy Lab. (NREL), Golden, CO (United States); Thomson, Jim [Univ. of Washington, Seattle, WA (United States); Talbert, Joe [Univ. of Washington, Seattle, WA (United States); DeKlerk, Alex [Univ. of Washington, Seattle, WA (United States)

    2016-03-01

    This work details a methodology for measuring hub height inflow turbulence using moored acoustic Doppler velocimiters (ADVs). This approach is motivated by the shortcomings of alternatives. For example, remote velocity measurements (i.e., from acoustic Doppler profilers) lack sufficient precision for device simulation, and rigid tower-mounted measurements are very expensive and technically challenging in the tidal environment. Moorings offer a low-cost, site-adaptable and robust deployment platform, and ADVs provide the necessary precision to accurately quantify turbulence.

  18. Technical Needs for Prototypic Prognostic Technique Demonstration for Advanced Small Modular Reactor Passive Components

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Ryan M.; Coble, Jamie B.; Hirt, Evelyn H.; Ramuhalli, Pradeep; Mitchell, Mark R.; Wootan, David W.; Berglin, Eric J.; Bond, Leonard J.; Henager, Charles H.

    2013-05-17

    This report identifies a number of requirements for prognostics health management of passive systems in AdvSMRs, documents technical gaps in establishing a prototypical prognostic methodology for this purpose, and describes a preliminary research plan for addressing these technical gaps. AdvSMRs span multiple concepts; therefore a technology- and design-neutral approach is taken, with the focus being on characteristics that are likely to be common to all or several AdvSMR concepts. An evaluation of available literature is used to identify proposed concepts for AdvSMRs along with likely operational characteristics. Available operating experience of advanced reactors is used in identifying passive components that may be subject to degradation, materials likely to be used for these components, and potential modes of degradation of these components. This information helps in assessing measurement needs for PHM systems, as well as defining functional requirements of PHM systems. An assessment of current state-of-the-art approaches to measurements, sensors and instrumentation, diagnostics and prognostics is also documented. This state-of-the-art evaluation, combined with the requirements, may be used to identify technical gaps and research needs in the development, evaluation, and deployment of PHM systems for AdvSMRs. A preliminary research plan to address high-priority research needs for the deployment of PHM systems to AdvSMRs is described, with the objective being the demonstration of prototypic prognostics technology for passive components in AdvSMRs. Greater efficiency in achieving this objective can be gained through judicious selection of materials and degradation modes that are relevant to proposed AdvSMR concepts, and for which significant knowledge already exists. These selections were made based on multiple constraints including the analysis performed in this document, ready access to laboratory-scale facilities for materials testing and measurement, and

  19. Estimating Operational Risk for Hedge Funds: The ?-Score

    OpenAIRE

    Stephen Brown; William Goetzmann; Bing Liang; Christopher Schwarz

    2008-01-01

    Using a complete set of the SEC filing information on hedge funds (Form ADV) and the TASS data, we develop a quantitative model called the ?-Score to measure hedge fund operational risk. The ?-Score is related to conflict of interest issues, concentrated ownership, and reduced leverage in the ADV data. With a statistical methodology, we further relate the ?-Score to readily available information such as fund performance, volatility, size, age, and fee structures. Finally, we demonstrate that ...

  20. Role of alveolar type II cells and of surfactant-associated protein C mRNA levels in the pathogenesis of respiratory distress in mink kits infected with Aleutian mink disease parvovirus.

    OpenAIRE

    Viuff, B; Aasted, B; Alexandersen, S.

    1994-01-01

    Neonatal mink kits infected with Aleutian mink disease parvovirus (ADV) develop an acute interstitial pneumonia with clinical symptoms and pathological lesions that resemble those seen in preterm human infants with respiratory distress syndrome and in human adults with adult respiratory distress syndrome. We have previously suggested that ADV replicates in the alveolar type II epithelial cells of the lung. By using double in situ hybridization, with the simultaneous use of a probe to detect A...

  1. Improved real-time PCR assay for detection and quantification of all 54 known types of human adenoviruses in clinical samples

    Science.gov (United States)

    Bil-Lula, Iwona; De Franceschi, Nicola; Pawlik, Krzysztof; WoŸniak, Mieczysław

    2012-01-01

    Summary Background Detection and quantification of adenoviruses (AdVs) causing life-threatening complications are important abilities in recognition of infection and management of immunocompromised patients. Due to the rapid increase in the number of known AdV types, most commercial tests for detection and identification of AdVs are outdated. Material/Methods We designed an improved, easier and faster real-time quantitative polymerase chain reaction (RQ-PCR) method for detection and quantification of 54 types of human AdVs. A wide validation effort was undertaken to ensure confidence in highly sensitive and specific detection of AdVs in compromised patients. The validation process included evaluation of the method’s suitability and reliability for use in routine diagnostics. Results Due to high sensitivity (9.2×102 copies/ml) and broad dynamic range (7 log) we are able to detect specific viral DNA in large amounts of cell-free body fluids. The new assay is characterized by high precision and low variation within and between individual virus tests (CV=0.036%, CV=1.29%), low bias error (4%) and no cross-reactivity with other pathogens. Conclusions The implementation of this new assay in clinical and laboratory practice provides a rapid, reliable and less laborious method for detection and monitoring of AdV replication in immunocompromised patients. Moreover, it offers the ability to distinguish between active and latent infection and assess treatment efficiency. PMID:22648243

  2. Ad 2.0: a novel recombineering platform for high-throughput generation of tailored adenoviruses.

    Science.gov (United States)

    Mück-Häusl, Martin; Solanki, Manish; Zhang, Wenli; Ruzsics, Zsolt; Ehrhardt, Anja

    2015-04-30

    Recombinant adenoviruses containing a double-stranded DNA genome of 26-45 kb were broadly explored in basic virology, for vaccination purposes, for treatment of tumors based on oncolytic virotherapy, or simply as a tool for efficient gene transfer. However, the majority of recombinant adenoviral vectors (AdVs) is based on a small fraction of adenovirus types and their genetic modification. Recombineering techniques provide powerful tools for arbitrary engineering of recombinant DNA. Here, we adopted a seamless recombineering technology for high-throughput and arbitrary genetic engineering of recombinant adenoviral DNA molecules. Our cloning platform which also includes a novel recombination pipeline is based on bacterial artificial chromosomes (BACs). It enables generation of novel recombinant adenoviruses from different sources and switching between commonly used early generation AdVs and the last generation high-capacity AdVs lacking all viral coding sequences making them attractive candidates for clinical use. In combination with a novel recombination pipeline allowing cloning of AdVs containing large and complex transgenes and the possibility to generate arbitrary chimeric capsid-modified adenoviruses, these techniques allow generation of tailored AdVs with distinct features. Our technologies will pave the way toward broader applications of AdVs in molecular medicine including gene therapy and vaccination studies. PMID:25609697

  3. Chemistry and Mineralogy of Antarctica Dry Valley Soils: Implications for Mars

    Science.gov (United States)

    Quinn, J. E.; Golden, D. C.; Graff, T. G.; Ming, D. W.; Morris, R. V.; Douglas, S.; Kounaves, S. P.; McKay, C. P.; Tamppari, L, K.; Smith, P. H.; Zent, A. P.; Archer, P. D., Jr.

    2011-01-01

    The Antarctic Dry Valleys (ADV) comprise the largest ice-free region of Antarctica. Precipitation almost always occurs as snow, relative humidity is frequently low, and mean annual temperatures are about -20 C. The ADV soils have previously been categorized into three soil moisture regimes: subxerous, xerous and ultraxerous, based on elevation and climate influences. The subxerous regime is predominately a coastal zone soil, and has the highest average temperature and precipitation, while the ultraxerous regime occurs at high elevation (>1000 m) and have very low temperature and precipitation. The amounts and types of salts present in the soils vary between regions. The nature, origin and significance of salts in the ADV have been previously investigated. Substantial work has focused on soil formation in the ADVs, however, little work has focused on the mineralogy of secondary alteration phases. The dominant weathering process in the ADV region is physical weathering, however, chemical weathering has been well documented. The objective of this study was to characterize the chemistry and mineralogy, including the alteration mineralogy, of soils from two sites, a subxerous soil in Taylor Valley, and an ultraxerous soil in University Valley. The style of aqueous alteration in the ADVs may have implications for pedogenic processes on Mars.

  4. Development and validation of a novel hydrolysis probe real-time polymerase chain reaction for agamid adenovirus 1 in the central bearded dragon (Pogona vitticeps).

    Science.gov (United States)

    Fredholm, Daniel V; Coleman, James K; Childress, April L; Wellehan, James F X

    2015-03-01

    Agamid adenovirus 1 (AgAdv-1) is a significant cause of disease in bearded dragons (Pogona sp.). Clinical manifestations of AgAdv-1 infection are variable and often nonspecific; the manifestations range from lethargy, weight loss, and inappetence, to severe enteritis, hepatitis, and sudden death. Currently, diagnosis of AgAdv-1 infection is achieved through a single published method: standard nested polymerase chain reaction (nPCR) and sequencing. Standard nPCR with sequencing provides reliable sensitivity, specificity, and validation of PCR products. However, this process is comparatively expensive, laborious, and slow. Probe hybridization, as used in a TaqMan assay, represents the best option for validating PCR products aside from the time-consuming process of sequencing. This study developed a real-time PCR (qPCR) assay using a TaqMan probe-based assay, targeting a highly conserved region of the AgAdv-1 genome. Standard curves were generated, detection results were compared with the gold standard conventional PCR and sequencing assay, and limits of detection were determined. Additionally, the qPCR assay was run on samples known to be positive for AgAdv-1 and samples known to be positive for other adenoviruses. Based on the results of these evaluations, this assay allows for a less expensive, rapid, quantitative detection of AgAdv-1 in bearded dragons. PMID:25776549

  5. Prevalence of neutralising antibodies against adenoviruses in lizards and snakes.

    Science.gov (United States)

    Ball, Inna; Ofner, Sabine; Funk, Richard S; Griffin, Chris; Riedel, Ulf; Möhring, Jens; Marschang, Rachel E

    2014-10-01

    Adenoviruses (AdVs) are relatively common in lizards and snakes, and several genetically distinct AdVs have been isolated in cell culture. The aims of this study were to examine serological relationships among lizard and snake AdVs and to determine the frequency of AdV infections in these species. Isolates from a boa constrictor (Boa constrictor), a corn snake (Pantherophis gutattus) and a central bearded dragon (Pogona vitticeps), and two isolates from helodermatid lizards (Heloderma horridum and H. suspectum) were used in neutralisation tests for the detection of antibodies in plasma from 263 lizards from seven families (including 12 species) and from 141 snakes from four families (including 28 species) from the USA and Europe. Most lizard and snake samples had antibodies against a range of AdV isolates, indicating that AdV infection is common among these squamates. Neutralisation tests with polyclonal antibodies raised in rabbits demonstrated serological cross-reactivity between both helodermatid lizard isolates. However, squamate plasma showed different reactions to each of these lizard isolates in neutralisation tests. PMID:25163614

  6. Colored ultra-thin hybrid photovoltaics with high quantum efficiency for decorative PV applications (Presentation Recording)

    Science.gov (United States)

    Guo, L. Jay

    2015-10-01

    adopted by other material systems as well. Based on these understandings, we have also developed colored perovskite PV by integrating an optical cavity with the perovskite semiconductors [4]. The principle and experimental results will be presented. 1. J. Y. Lee, K. T. Lee, S.Y. Seo, L. J. Guo, "Decorative power generating panels creating angle insensitive transmissive colors," Sci. Rep. 4, 4192, 2014. 2. K. T. Lee, J.Y. Lee, S.-Y. Seo, and L. J. Guo, "Colored ultra-thin hybrid photovoltaics with high quantum efficiency," Light: Science and Applications, 3, e215, 2014. 3. K. T. Lee, S.-Y. Seo, J.Y. Lee, and L. J. Guo, "Ultrathin metal-semiconductor-metal resonator for angle invariant visible band transmission filters," Appl. Phys. Lett. 104, 231112, (2014); and "Strong resonance effect in a lossy medium-based optical cavity for angle robust spectrum filters," Adv. Mater, 26, 6324-6328, 2014. 4. K. T. Lee, M. Fukuda, L. J. Guo, "Colored, see-through perovskite solar cells employing an optical cavity," Submitted, 2015

  7. Hydrochromic Approaches to Mapping Human Sweat Pores.

    Science.gov (United States)

    Park, Dong-Hoon; Park, Bum Jun; Kim, Jong-Man

    2016-06-21

    colorimetric change near body temperature. This feature enables the use of this technique to generate high-quality images of sweat pores. This Account also focuses on the results of the most recent phase of this investigation, which led to the development of a simple yet efficient and reliable technique for sweat pore mapping. The method utilizes a hydrophilic polymer composite film containing fluorescein, a commercially available dye that undergoes a fluorometric response as a result of water-dependent interconversion between its ring-closed spirolactone (nonfluorescent) and ring-opened fluorone (fluorescent) forms. Surface-modified carbon nanodots (CDs) have also been found to be efficient for hydrochromic mapping of human sweat pores. The results discovered by Lou et al. [ Adv. Mater. 2015 , 27 , 1389 ] are also included in this Account. Sweat pore maps obtained from fingertips using these materials were found to be useful for fingerprint analysis. In addition, this hydrochromism-based approach is sufficiently sensitive to enable differentiation between sweat-secreting active pores and inactive pores. As a result, the techniques can be applied to clinical diagnosis of malfunctioning sweat pores. The directions that future research in this area will follow are also discussed. PMID:27159417

  8. Imaging nanomaterials in vitro and in vivo by exploring their intrinsic nonlinear optical signals

    Science.gov (United States)

    Tong, Ling

    . First, receptor-medicated endocytosis is visualized with a polymeric nanoparticle-based CARS probe (J. Phys. Chem. B, 2007, 111, 9980-9985). Second, the cellular drug delivery mechanism by poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) is reexamined by CARS microscopy and new discoveries that PLGA NPs are not readily taken up by cells and delivered the payload to cells by extracellular drug release and/or direct drug transfer to contacting cells are found (Mol. Pharmaceutics, 2009, 6, 190-201). Third, the sensitivity of SRS microscopy is improved to monitor liposomal drug delivery in live cells. The last part of my thesis depicts the applications of GNRs in diagnosis and phtotothermal therapy of tumor cells and activated macrophages. Photothermal effect of GNRs is monitored by TPL, confocal microscopy and biological assays. The formation of membrane blebs is observed. The subcellular mechanism is investigated to be a downstream effect of compromised membrane integrity, which permits influx of calcium and subsequent disruption of the actin network (Adv. Mater. 2007, 109, 3136-3141, cover story). In addition, cell death through necrosis or apoptosis is induced by controlling laser irradiation. The molecular mechanisms are determined as the loss of plasma membrane integrity for necrosis and intracellular perturbation with damage of mitochondria for apoptosis (Nanomedicine, 2009, 4, 265-276).

  9. Dicty_cDB: CHD848 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available osing malaria and immune antigen for suppressing growth of plasmodium. 58 4e-16 5 BD183625 |BD183625.1 Mater...ial for diagnosing malaria and immune antigen for suppressing growth of plasmodium

  10. Arvo Pärdi sünnipäeva tähistas topeltkontserdielamus / Inna Grünfeldt

    Index Scriptorium Estoniae

    Grünfeldt, Inna, 1961-

    2008-01-01

    Ants Juhani Neeme "Laulud kaugelt" ettekandest Virumaa Kammerorkestri esituses 11. sept. Rakvere Gümnaasiumi saalis ning Arvo Pärdi teose "Magnificat" ja Haydni teose "Stabat Mater" ettekandest dirigent Daniel Reussi juhatusel kirikus

  11. EPILEPSY AND EDUCATION AND PREVENTION ACTIVITIES (EP) DATABASE

    Science.gov (United States)

    This database contains entries that focus on epilepsy education and prevention emphasizing the application of effective early detection and control program activities and risk reduction efforts. The database provides bibliographic citations and abstracts of various types of mater...

  12. Online Real-Time Tribology Failure Detection System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The investigation of the coating friction as a function of time is important to monitor the ball bearing heath. Despite the importance of the subject mater, there...

  13. DEPLETED URANIUM TECHNICAL WORK

    Science.gov (United States)

    The Depleted Uranium Technical Work is designed to convey available information and knowledge about depleted uranium to EPA Remedial Project Managers, On-Scene Coordinators, contractors, and other Agency managers involved with the remediation of sites contaminated with this mater...

  14. Kristjan Järvi juhatab Pärdi maailmaesiettekannet Viinis / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2008-01-01

    Arvo Pärdi teose "Stabat Mater" segakoori- ja keelpilliorkestriversiooni maailmaesiettekandest 12. juunil Viinis ja dirigent Kristjan Järvi tegemistest. Bariton Lauri Vasar laulmas Hans Werner Henze ooperis "Phaedra" Berliinis, Brüsselis ja Viinis

  15. Stability of rotating supermassive stars in presence of dark matter background

    OpenAIRE

    Bisnovatyi-Kogan, G S

    1997-01-01

    Stability of supermassive stars embedded in hot dark matter is investigated on the base of the energetic method. Stability effect of dark mater is compared with rotational stabilization and preference of the last factor is advocated.

  16. MATERNAL AGE EFFECT: THE ENIGMA OF DOWN SYNDROME AND OTHER TRISOMIC CONDITIONS

    Science.gov (United States)

    Aneuploidy is the most frequently observed chromosome abnormality in human liveborn, abortuses, and oocytes. he only etiological factor that has been established is advanced maternal age for the occurrence of trisomies, particularly trisomy 21 which causes Down syndrome. he mater...

  17. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

    OpenAIRE

    Aspelund, Aleksanteri; Antila, Salli; Proulx, Steven T; Karlsen, Tine Veronica; Karaman, Sinem; Detmar, Michael; Wiig, Helge; Alitalo, Kari

    2015-01-01

    Aspelund et al. discover the presence of a lymphatic vessel network in the dura mater of the mouse brain and show that these dural lymphatic vessels are important for the clearance of macromolecules from the brain.

  18. VISCOELASTIC PROPERTIES OF A BIOLOGICAL HYDROGEL PRODUCED FROM SOYBEAN OIL

    Science.gov (United States)

    Hydrogels formed from biopolymers or natural sources have special advantages because of their biodegradable and biocompatible properties. The viscoelastic properties of a newly developed biological hydrogel made from modified vegetable oil, epoxidized soybean oil (ESO) were investigated. The mater...

  19. Novel Approach to the Dark Matter Problem: Primordial Intermediate-Mass Black Holes

    OpenAIRE

    Frampton, Paul H.

    2016-01-01

    A discussion at a Scientific American level of the idea that the constituents of the dark mater in galactic halos are primordial intermediate-mass black holes with masses between ten and one hundred thousand times the solar mass.

  20. CONSORT: Effects of adding adefovirdipivoxil to peginterferon alfa-2a at different time points on HBeAg-positivepatients

    Science.gov (United States)

    Zhang, Ka; Cao, Hong; Liang, Jiayi; Shu, Xin; Sun, Haixia; Li, Gang; Xu, Qihuan

    2016-01-01

    Abstract Background: The aims of this study were to compare the efficacy and safety of the addition of adefovir dipivoxil (ADV) (started at different time points) to pegylated interferon alpha-2a (PEG-INF-α2a) and PEG-INF-α2a monotherapy. This prospective, randomized study sought to evaluate the safety and efficacy of the combination of PEG-INF-α2a and ADV at different time points.120 patients were randomized into groups that received PEG-INF-α2a as monotherapy (group A) or in combination with ADV started at week 0 (group B), 12 (group C), or 24 (group D). All patients were followed for 48 weeks. Efficacy and safety analyses were performed. Methods: Patients in group a received 135 μg of PEG-INF-α2a by subcutaneous injection once weekly for 48 weeks. Patients in the ADV add-on group received 135 μg of PEG-INF-α2a subcutaneously once weekly and received 10 mg of ADV administered once daily for 48 weeks. HBV DNA, HBsAg, HBeAg, and hepatitis B e antibody levels were determined. Responses were determined at week 12 (ADV add-on), the end of treatment for PEG-INF-α2a (48weeks) and ADV (EOT) and at the end of 96 weeks of follow-up (EOF). Results: The rate of HBV DNA loss were higher in the combination groups than group A at the week 12, week 48, the EOT and EOF (P 0.05). The alanineaminotransferase (ALT) normalization rate was higher in the combination group than group A only at the EOT (P = 0.007). By the EOF, the patients with ADV added at week 12 achieved higher rates of HBV DNA loss (71.9%), HBeAg seroconversion (50.0%), HBsAg loss (15.6%), and ALT normalization (78.1%). Conclusions: PEG-INF-α2a plus ADV combination therapy is safe and superior to PEG-INF-α2amonotherapyfor decreasing serum HBV DNA and normalizing the ALT level but has no significant impact on the rate of HBeAg seroconversion and HBsAg loss. Adding ADV at week 12 may be an optimal combination strategy. PMID:27495085

  1. Investigation of enteric adenovirus and poliovirus removal by coagulation processes and suitability of bacteriophages MS2 and φX174 as surrogates for those viruses.

    Science.gov (United States)

    Shirasaki, N; Matsushita, T; Matsui, Y; Marubayashi, T; Murai, K

    2016-09-01

    We evaluated the removal of enteric adenovirus (AdV) type 40 and poliovirus (PV) type 1 by coagulation, using water samples from 13 water sources for drinking water treatment plants in Japan. The behaviors of two widely accepted enteric virus surrogates, bacteriophages MS2 and φX174, were compared with the behaviors of AdV and PV. Coagulation with polyaluminum chloride (PACl, basicity 1.5) removed AdV and PV from virus-spiked source waters: the infectious AdV and PV removal ratios evaluated by means of a plaque-forming-unit method were 0.1-1.4-log10 and 0.5-2.4-log10, respectively. A nonsulfated high-basicity PACl (basicity 2.1) removed infectious AdV and PV more efficiently than did other commercially available PACls (basicity 1.5-2.1), alum, and ferric chloride. The MS2 removal ratios tended to be larger than those of AdV and PV, partly because of differences in the hydrophobicities of the virus particles and the sensitivity of the virus to the virucidal activity of PACl; the differences in removal ratios were not due to differences in the surface charges of the virus particles. MS2, which was more hydrophobic than the other viruses, was inactivated during coagulation with PACl. Therefore, MS2 does not appear to be an appropriate surrogate for AdV and PV during coagulation. In contrast, because φX174, like AdV and PV, was not inactivated during coagulation, and because the hydrophobicity of φX174 was similar to or somewhat lower than the hydrophobicities of AdV and PV, the φX174 removal ratios tended to be similar to or somewhat smaller than those of the enteric viruses. Therefore, φX174 is a potential conservative surrogate for AdV and PV during coagulation. In summary, the surface hydrophobicity of virus particles and the sensitivity of the virus to the virucidal activity of the coagulant are probably important determinants of the efficiency of virus removal during coagulation. PMID:27135564

  2. Diagnostic value of MRI in hypertrophic pachymeningitis

    Directory of Open Access Journals (Sweden)

    Li-jing SHI

    2016-03-01

    Full Text Available Objective  To investigate the diagnostic value of MRI in hypertrophic pachymeningitis (HP. Methods  MRI images of 11 patients with HP were analyzed retrospectively. The characteristic signs of the MRI images, and the relationship between the MRI features and pathology of HP were reviewed. Results  In the 11 cases of HP, involvement of cerebral dura mater accounted for 8 cases, with spinal dura mater involvement in 2, both cerebral and spinal dura mater involvement in the other one case. The main sign of HP in MRI was an increased thickness of the dura mater, which showed iso-or hypointensity on T1WI without significant difference as compared with the brain parenchyma and spinal cord. The thickened dura mater showed obviously low signal on T2WI, and it was recognized easily as compared with the brain parenchyma and the spinal cord. On the DWI of 9 cases who had cerebral dura mater involvement, increased dura mater showed lower signal, but it was not so distinct as shown on T2WI. On the post-contrast T1WI, the thickened dura mater showed obvious enhancement, displaying better images than that of pre-enhancement image. Conclusion  Among the different MRI techniques, T2-weighted imaging and post-enhanced T1WI have their advantages in the diagnosis of HP, and other MR imaging techniques could be complementary in increasing diagnostic accuracy and comprehensiveness. DOI: 10.11855/j.issn.0577-7402.2016.02.13

  3. Exercise physiologists: essential players in interdisciplinary teams for noncommunicable chronic disease management

    OpenAIRE

    Soan EJ; Street SJ; Brownie SM; Hills AP

    2014-01-01

    Esme J Soan,1–3 Steven J Street,1,2 Sharon M Brownie,3,4 Andrew P Hills1–31Mater Mothers' Hospital, South Brisbane, 2Mater Research Institute – University of Queensland, South Brisbane, 3Griffith Health Institute, Griffith University, Gold Coast, QLD, Australia; 4Green Templeton College, Oxford University, Oxford, UKAbstract: Noncommunicable diseases (NCDs), such as obesity and type 2 diabetes mellitus, are a growing public health challenge in Australia, ...

  4. Increased dendritic spine density and tau expression are associated with individual differences in steroidal regulation of male sexual behavior.

    Directory of Open Access Journals (Sweden)

    Pranay Bharadwaj

    Full Text Available Male sexual behavior (MSB is modulated by gonadal steroids, yet this relationship is highly variable across species and between individuals. A significant percentage (~30% of B6D2F1 hybrid male mice demonstrate MSB after long-term orchidectomy (herein after referred to as "maters", providing an opportunity to examine the mechanisms that underlie individual differences in steroidal regulation of MSB. Use of gene expression arrays comparing maters and non-maters has provided a first pass look at the genetic underpinnings of steroid-independent MSB. Surprisingly, of the ~500 genes in the medial preoptic area (MPOA that differed between maters and non-maters, no steroid hormone or receptor genes were differentially expressed between the two groups. Interestingly, best known for their association with Alzheimer's disease, amyloid precursor protein (APP and the microtubule-associated protein tau (MAPT were elevated in maters. Increased levels of their protein products (APP and tau in their non-pathological states have been implicated in cell survival, neuroprotection, and supporting synaptic integrity. Here we tested transgenic mice that overexpress tau and found facilitated mounting and intromission behavior after long-term orchidectomy relative to littermate controls. In addition, levels of synaptophysin and spinophilin, proteins generally enriched in synapses and dendritic spines respectively, were elevated in the MPOA of maters. Dendritic morphology was also assessed in Golgi-impregnated brains of orchidectomized B6D2F1 males, and hybrid maters exhibited greater dendritic spine density in MPOA neurons. In sum, we show for the first time that retention of MSB in the absence of steroids is correlated with morphological differences in neurons.

  5. Controlled light field concentration through turbid biological membrane for phototherapy

    OpenAIRE

    Wang, Fujuan; He, Hexiang; Zhuang, Huichang; Xie, Xiangsheng; Yang, Zhenchong; Cai, Zhigang; Gu, Huaiyu; Zhou, Jianying

    2015-01-01

    Laser propagation through a turbid rat dura mater membrane is shown to be controllable with a wavefront modulation technique. The scattered light field can be refocused into a target area behind the rat dura mater membrane with a 110 times intensity enhancement using a spatial light modulator. The efficient laser intensity concentration system is demonstrated to imitate the phototherapy for human brain tumors. The power density in the target area is enhanced more than 200 times compared with ...

  6. Achievement of cardiovascular risk factor targets in young adults with diabetes mellitus

    OpenAIRE

    DONOVAN, PETER J.; H David McIntyre

    2010-01-01

    Peter J Donovan, H David McIntyreDepartment of Endocrinology, Mater Health Services, Mater Clinical School, The University of Queensland School of Medicine, South Brisbane, QLD, AustraliaBackground: Many patients with diabetes mellitus fail to achieve treatment targets recommended in recognized guidelines. Little data is available in this area relating to young adults.Objective: To assess whether treatment goals for glycosylated hemoglobin (HbA1c), blood pressure, lipid-lowering, and process ...

  7. A long-term serological survey on Aujeszky's disease virus infections in wild boar in East Germany.

    Science.gov (United States)

    Pannwitz, G; Freuling, C; Denzin, N; Schaarschmidt, U; Nieper, H; Hlinak, A; Burkhardt, S; Klopries, M; Dedek, J; Hoffmann, L; Kramer, M; Selhorst, T; Conraths, F J; Mettenleiter, T; Müller, T

    2012-02-01

    Between 1985 and 2008, a total of 102,387 wild boar sera originating from Eastern Germany covering an area of 108 589 km2 were tested for the presence of Aujeszky's disease virus (ADV)-specific antibodies. From 1985 until 1991 and from 1992 until 2008, wild boar sera were exclusively investigated using either conventional seroneutralization assays (n=39 621) or commercial gB and full antigen ELISAs (n=62,766), respectively. Spatial-temporal analysis revealed an increasing ADV seroprevalence from 0·4% to 15·9%, on average, during the 24-year observation period that went along with a continuous spread of the infection in a western direction. During 2006 and 2008, 18% of the 66 affected districts had ADV seroprevalences >30%. There was a significant correlation between ADV seroprevalence and the hunting index of population density (HIPD) of wild boar in the entire study area, although this did not hold true for some regions. Seroprevalences did not differ between sexes but were age-dependent. East Germany has been officially free of Aujeszky's disease (pseudorabies) in domestic pigs since 1985. Although a risk for domestic pigs cannot be completely ruled out, experience has shown that ADV in domestic pigs could be eliminated although the virus was present in the wild boar population. Despite increasing ADV seroprevalence in the East German wild boar population no spillover infections from wild boar to domestic pigs have been reported. To further trace ADV infections in the wild boar population in Germany, a nationwide serological monitoring programme should be implemented. PMID:21320372

  8. Scavenging dissolved oxygen via acoustic droplet vaporization.

    Science.gov (United States)

    Radhakrishnan, Kirthi; Holland, Christy K; Haworth, Kevin J

    2016-07-01

    Acoustic droplet vaporization (ADV) of perfluorocarbon emulsions has been explored for diagnostic and therapeutic applications. Previous studies have demonstrated that vaporization of a liquid droplet results in a gas microbubble with a diameter 5-6 times larger than the initial droplet diameter. The expansion factor can increase to a factor of 10 in gassy fluids as a result of air diffusing from the surrounding fluid into the microbubble. This study investigates the potential of this process to serve as an ultrasound-mediated gas scavenging technology. Perfluoropentane droplets diluted in phosphate-buffered saline (PBS) were insonified by a 2 MHz transducer at peak rarefactional pressures lower than and greater than the ADV pressure amplitude threshold in an in vitro flow phantom. The change in dissolved oxygen (DO) of the PBS before and after ADV was measured. A numerical model of gas scavenging, based on conservation of mass and equal partial pressures of gases at equilibrium, was developed. At insonation pressures exceeding the ADV threshold, the DO of air-saturated PBS decreased with increasing insonation pressures, dropping as low as 25% of air saturation within 20s. The decrease in DO of the PBS during ADV was dependent on the volumetric size distribution of the droplets and the fraction of droplets transitioned during ultrasound exposure. Numerically predicted changes in DO from the model agreed with the experimentally measured DO, indicating that concentration gradients can explain this phenomenon. Using computationally modified droplet size distributions that would be suitable for in vivo applications, the DO of the PBS was found to decrease with increasing concentrations. This study demonstrates that ADV can significantly decrease the DO in an aqueous fluid, which may have direct therapeutic applications and should be considered for ADV-based diagnostic or therapeutic applications. PMID:26964964

  9. Identification of Human Adenovirus in Respiratory Samples with Luminex Respiratory Virus Panel Fast V2 Assay and Real-Time Polymerase Chain Reaction.

    Science.gov (United States)

    Esposito, Susanna; Scala, Alessia; Bianchini, Sonia; Zampiero, Alberto; Fossali, Emilio; Principi, Nicola

    2016-01-01

    In order to compare the last version of the Respiratory Virus Panel (RVP) Fast assay for human Adenovirus (hAdv) detection with a specific real-time polymerase chain reaction (qPCR), which is considered the gold standard for hAdv detection, nasopharyngeal samples collected from 309 children (age range, four months to eight years) with respiratory tract infection were tested using the RVP Fast v2 assay (Luminex Molecular Diagnostics, Inc., Toronto, ON, Canada) and a specific TaqMan qPCR to identify hAdv DNA. The RVP Fast v2 assay detected 30/61 (49.2%) hAdv infections that had been identified by real-time qPCR, demonstrating a significantly lower detection rate (p < 0.001). The sensitivity of the RVP Fast v2 assay in comparison to qPCR was lower in younger children (42.9% vs. 57.7%; Cohen's kappa coefficient, 0.53); in samples with co-infections (40.0% vs. 56.7%; Cohen's kappa coefficient, 0.52); and in samples with hAdv type C (45.9% vs. 57.1%; Cohen's kappa coefficient, 0.60). Samples with lower viral loads were associated with a significantly lower sensitivity of the RVP Fast v2 assay (35.1% vs. 68.2%, p = 0.01; Cohen's kappa coefficients, 0.49). The RVP Fast v2 assay has important limitations for the detection of hAdv and cannot be used to evaluate whether hAdvs are the main etiologic agent responsible for an outbreak or when epidemiological studies are performed. PMID:26927078

  10. The Efficacy of Add-on Telbivudine Versus Switching to Pegylated Interferon Alfa-2a in Chronic Hepatitis B Patients With Poor Responses to Adefovir

    Directory of Open Access Journals (Sweden)

    Wei

    2016-01-01

    Full Text Available Background There are limited options for chronic hepatitis B (CHB patients who have poor responses to adefovir (ADV. Objectives The aim of this study is to evaluate the effects of adding on telbivudine (LdT or switching to pegylated interferon alfa-2a (PEG-IFN-α2a as alternative rescue therapies for patients with poor responses to the initial ADV treatments. Patients and Methods Ninety-seven CHB patients with HBV DNA > 2 log10 copies/mL 48 weeks after ADV monotherapy were included in this study. Fifty-nine of these patients were treated with a combination of LdT plus ADV (LdT + ADV daily, while thirty-eight patients were switched to PEG-IFN-α2a subcutaneous injections weekly for 48 weeks. Results Both rescue strategies were proven to be safe and the majority of patients tolerated the therapies well. LdT + ADV led to more rapid reductions in viral loads than PEG-IFN-α2a monotherapy, with 2.14 (LdT + ADV and 0.98 (PEG-IFN-α2a log10 copies/mL decreases 48 weeks after rescue treatments, respectively (P < 0.00001. The rates corresponding to virological and biochemical responses were also elevated in patients who received the LdT + ADV combination therapy at the end of the observation period (88.1 vs. 68.4% for virological response, P = 0.017; 83.3 vs. 47.2%, P = 0.00045. However, the decline in the hepatitis B surface antigen (HBsAg was more pronounced in PEG-IFN-α2a treated patients. Moreover, the cumulative rates of serological responses were higher in patients who switched to the PEG-IFN-α2a therapy. Conclusions Both add-on LdT and switching to PEG-IFN-α2a were satisfactory and optimal treatments for CHB patients with poor responses to ADV. Both rescue strategies resulted in significant reductions in serum viral load and ALT levels, and were associated with high rate of serological outcomes in our hospital.

  11. High-Density Superconducting Cables for Advanced ACTPol

    Science.gov (United States)

    Pappas, C. G.; Austermann, J.; Beall, J. A.; Duff, S. M.; Gallardo, P. A.; Grace, E.; Henderson, S. W.; Ho, S. P.; Koopman, B. J.; Li, D.; McMahon, J.; Nati, F.; Niemack, M. D.; Niraula, P.; Salatino, M.; Schillaci, A.; Schmitt, B. L.; Simon, S. M.; Staggs, S. T.; Stevens, J. R.; Vavagiakis, E. M.; Ward, J. T.; Wollack, E. J.

    2016-01-01

    Advanced ACTPol (AdvACT) is an upcoming Atacama Cosmology Telescope (ACT) receiver upgrade, scheduled to deploy in 2016, that will allow measurement of the cosmic microwave background polarization and temperature to the highest precision yet with ACT. The AdvACT increase in sensitivity is partly provided by an increase in the number of transition-edge sensors (TESes) per array by up to a factor of two over the current ACTPol receiver detector arrays. The high-density AdvACT TES arrays require 70 \\upmu m pitch superconducting flexible cables (flex) to connect the detector wafer to the first-stage readout electronics. Here, we present the flex fabrication process and test results. For the flex wiring layer, we use a 400-nm-thick sputtered aluminum film. In the center of the cable, the wiring is supported by a polyimide substrate, which smoothly transitions to a bare (uncoated with polyimide) silicon substrate at the ends of the cable for a robust wedge wire-bonding interface. Tests on the first batch of flex made for the first AdvACT array show that the flex will meet the requirements for AdvACT, with a superconducting critical current above 1 mA at 500 mK, resilience to mechanical and cryogenic stress, and a room temperature yield of 97 %.

  12. Binding sensitivity of adefovir to the polymerase from different genotypes of HBV: molecular modeling,docking and dynamics simulation studies

    Institute of Scientific and Technical Information of China (English)

    Jing LI; Yun DU; Xian LIU; Qian-cheng SHEN; Ai-long HUANG; Ming-yue ZHENG; Xiao-min LUO; Hua-liang JIANG

    2013-01-01

    Aim: To investigate the molecular mechanisms underlying the influence of DNA polymerase from different genotypes of hepatitis B virus (HBV) on the binding affinity of adefovir (ADV).Methods: Computational approaches,including homology modeling,docking,MD simulation and MM/PBSA free energy analyses were used.Results: Sequence analyses revealed that residue 238 near the binding pocket was not only a polymorphic site but also a genotypespecific site (His238 in genotype B; Asn238 in genotype C).The calculated binding free-energy supported the hypothesis that the polymerase from HBV genotype C was more sensitive to ADV than that from genotype B.By using MD simulation trajectory analysis,binding free energy decomposition and alanine scanning,some energy variation in the residues around the binding pocket was observed.Both the alanine mutations at residues 236 and 238 led to an increase of the energy difference between genotypes C and B (△△Gc-B),suggesting that these residues contributed to the genotype-associated antiviral variability with regard to the interaction with ADV.Conclusion: The results support the hypothesis that the HBV genotype C polymerase is more sensitive to ADV than that from genotype B.Moreover,residue N236 and the polymorphic site 238 play important roles in contributing to the higher sensitivity of genotype C over B in the interaction with ADV.

  13. Sequence and expression analyses of the UL37 and UL38 genes of Aujeszky's disease virus.

    Science.gov (United States)

    Braun, A; Kaliman, A; Boldogköi, Z; Aszódi, A; Fodor, I

    2000-01-01

    Previously, we sequenced the HSV-1 Ul39-Ul40 homologue genes of Aujeszky's disease virus (ADV), also designated as pseudorabies virus (Kaliman et al., 1994a, b). Now we report the nucleotide sequence of the adjacent DNA that encodes Ul38, the 5'-region (750 bp) of Ul37, and the promoter regions between these divergently arranged two genes. The ADV Ul38 gene encodes a protein of 368 amino acids. Amino acid sequence comparison of ADV Ul38 with that of other herpesviruses revealed significant structural homology. In a transcription study using RNase protection assay and Northern blot hybridization, we found that the Ul38 gene had one initiation site, but the Ul37 gene was initiated at two transcription sites with two potential initiator AUGs, one of which was dominant. Comparison of ADV Ul37, Ul38 and ribonucleotide reductase gene expression showed that these genes belong to the same temporal class with early kinetics. Data of structural and transcriptional studies suggest that regulation of the expression of these two ADV genes could differ from that of the HSV-1 virus. PMID:11402671

  14. Characterization of Acoustic Droplet Vaporization Using MRI

    Science.gov (United States)

    Li, David; Allen, Steven; Hernandez-Garcia, Luis; Bull, Joseph

    2013-11-01

    Acoustic droplet vaporization (ADV) is the selective vaporization of liquid droplets to form larger gas bubbles. The ADV process is currently being researched for biomedical applications such as gas embolotherapy, drug delivery, and phase-change contrast agents. In this study an albumin encapsulated dodecafluoropentane (DDFP, CAS: 678-26-2) microdroplet suspension was vaporized using a single element focused (f/2, D = 19 mm) 3.5 MHz transducer (Panametrics A321S, Olympus, Waltham, MA). The resulting DDFP bubble clouds were imaged using both bright field microscopy and MRI (Varian 7T, Agilent Technologies Inc., Santa Clara, CA). Field distortions due to DDFP bubble generation were characterized against the bright field images as a function of acoustic power and bubble cloud size. Experimentally a direct correlation between bubble cloud dimensions generated and field distortions seen in the MRI was observed. Additionally, MR velocimetry was used to measure the flow field resulting from ADV. The field distortions due to the bubbles were further characterized by modeling Maxwell's equations using COMSOL (COMSOL Inc., Burlington, MA). The ability to characterize ADV with alternative imaging modalities may prove useful in further development of ADV based biomedical therapies.

  15. Treatment of murine tumors using acoustic droplet vaporization-enhanced high intensity focused ultrasound

    Science.gov (United States)

    Zhu, Meili; Jiang, Lixing; Fabiilli, Mario L.; Zhang, Aili; Fowlkes, J. Brian; Xu, Lisa X.

    2013-09-01

    High intensity focused ultrasound (HIFU) can be applied focally and noninvasively to thermally ablate solid tumors. Long treatment times are typically required for large tumors, which can expose patients to certain risks while potentially decreasing the therapeutic efficacy of the treatment. Acoustic droplet vaporization (ADV) is a promising modality that can enhance the efficacy of tumor treatment using HIFU. In this study, the therapeutic effects of combined HIFU and ADV was evaluated in mice bearing subcutaneously-implanted 4T1 tumors. Histological examination showed that the combination of HIFU and ADV generated a mean necrotic area in the tumor that was 2.9-fold larger than with HIFU alone. A significant enhancement of necrosis was found in the periphery of the tumor, where the blood supply was abundant. Seven days after treatment, the tumors treated with combined HIFU and ADV were 30-fold smaller in volume than tumors treated with HIFU alone. The study demonstrates the potential advantage of combining HIFU and ADV in tumor treatment.

  16. Clinical and epidemiological aspects related to the detection of adenovirus or respiratory syncytial virus in infants hospitalized for acute lower respiratory tract infection

    Directory of Open Access Journals (Sweden)

    Eduardo A. Ferone

    2014-01-01

    Full Text Available OBJECTIVE: To characterize and compare clinical, epidemiological, and laboratory aspects ofinfants with acute lower respiratory infection (ALRI associated with the detection of adenovirus(ADV or respiratory syncytial virus (RSV. METHODS: A preliminary respiratory infection surveillance study collected samples of nasopharyngeal aspirate (NPA for viral research, linked to the completion of a standard protocol, from children younger than two years admitted to a university hospital with ALRI, between March of 2008 and August of 2011. Polymerase chain reaction (PCR was used for eight viruses: ADV, RSV, metapneumovirus, Parainfluenza 1, 2, and 3, and Influenza A and B. Cases with NPA collectedduring the first 24 hours of admission, negative results of blood culture, and exclusive detection of ADV (Gadv group or RSV (Grsv group were selected for comparisons. RESULTS: The preliminary study included collection of 1,121 samples of NPA, 813 collected in thefirst 24 hours of admission, of which 50.3% were positive for at least one virus; RSV was identifiedin 27.3% of cases surveyed, and ADV was identified in 15.8%. Among the aspects analyzed inthe Gadv (n = 58 and Grsv (n = 134 groups, the following are noteworthy: the higher meanage, more frequent prescription of antibiotics, and the highest median of total white blood cellcount and C-reactive protein values in Gadv. CONCLUSIONS: PCR can detect persistent/latent forms of ADV, an aspect to be considered wheninterpreting results. Additional studies with quantitative diagnostic techniques could elucidatethe importance of the high frequency observed.

  17. High-Density Superconducting Cables for Advanced ACTPol

    Science.gov (United States)

    Pappas, C. G.; Austermann, J.; Beall, J. A.; Duff, S. M.; Gallardo, P. A.; Grace, E.; Henderson, S. W.; Ho, S. P.; Koopman, B. J.; Li, D.; McMahon, J.; Nati, F.; Niemack, M. D.; Niraula, P.; Salatino, M.; Schillaci, A.; Schmitt, B. L.; Simon, S. M.; Staggs, S. T.; Stevens, J. R.; Vavagiakis, E. M.; Ward, J. T.; Wollack, E. J.

    2016-07-01

    Advanced ACTPol (AdvACT) is an upcoming Atacama Cosmology Telescope (ACT) receiver upgrade, scheduled to deploy in 2016, that will allow measurement of the cosmic microwave background polarization and temperature to the highest precision yet with ACT. The AdvACT increase in sensitivity is partly provided by an increase in the number of transition-edge sensors (TESes) per array by up to a factor of two over the current ACTPol receiver detector arrays. The high-density AdvACT TES arrays require 70 \\upmu m pitch superconducting flexible cables (flex) to connect the detector wafer to the first-stage readout electronics. Here, we present the flex fabrication process and test results. For the flex wiring layer, we use a 400-nm-thick sputtered aluminum film. In the center of the cable, the wiring is supported by a polyimide substrate, which smoothly transitions to a bare (uncoated with polyimide) silicon substrate at the ends of the cable for a robust wedge wire-bonding interface. Tests on the first batch of flex made for the first AdvACT array show that the flex will meet the requirements for AdvACT, with a superconducting critical current above 1 mA at 500 mK, resilience to mechanical and cryogenic stress, and a room temperature yield of 97 %.

  18. The Evolution of Advanced Merger (U)LIRGs on the Color-Stellar Mass Diagram

    Science.gov (United States)

    Guo, Rui; Hao, Cai-Na; Xia, Xiao-Yang

    2016-08-01

    Based on a sample of 79 local advanced merger (adv-merger) (U)LIRGs, we search for evidence of quenching processes by investigating the distributions of star formation history indicators (EW(Hα), EW(HΔA) and Dn(4000)) on the NUV-r color-mass and SFR-M * diagrams. The distributions of EW(Hα) and Dn(4000) on the NUV-r color-mass diagram show clear trends that at a given stellar mass, galaxies with redder NUV-r colors have smaller EW(Hα) and larger D n (4000). The reddest adv-merger (U)LIRGs close to the green valley mostly have D n (4000)> 1.4. In addition, in the SFR-M * diagram, as the SFR decreases, the EW(Hα) decreases and the D n (4000) increases, implying that the adv-merger (U)LIRGs on the star formation main sequence have more evolved stellar populations than those above the main sequence. These results indicate that a fraction of the adv-merger (U)LIRGs have already exhibited signs of fading from the starburst phase and that the NUV-r reddest adv-merger (U)LIRGs are likely at the initial stage of post-starbursts with an age of ∼ 1 Gyr, which is consistent with the gas exhaustion time-scales. Therefore, our results offer additional support for the fast evolutionary track from the blue cloud to the red sequence.

  19. Characterization of deoxyribonucleic acid from cells infected with Aleutian disease virus

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, E.C.; Ramos, L.; Kenyon, A.J.

    1983-07-01

    Viral DNA was extracted from Crandell feline kidney (CRFK) cells infected with Aleutian disease virus (ADV) and labeled with (/sup 3/H)thymidine. The sedimentation coefficient in alkaline sucrose gradients was 16S corresponding to a molecular weight of 1.5 X 10(6). The buoyant densities of DNA from infected and control cells were determined by isopyknic sedimentation in CsCl and NaI gradients. Two additional peaks of (/sup 3/H)DNA were found in infected cells, but not in control cell extracts. Fractionation of this DNA on hydroxylapatite indicated that the new peaks represented a single-stranded component, density 1.728 g/cm3, and a double-stranded component, presumed to be a viral replicative intermediate, density 1.718 g/cm3. The target antigen formation in CRFK cells was measured by gamma-irradiation of ADV and assayed for focus formation. The calculated size of ADV based on these measurements was 1.1 X 10(6). The H-1 parvovirus also was shown to have a size of 1.5 X 10(6) daltons for both antigen and plaque formation. The data indicated similarities existed between ADV and other autonomously replicating parvoviruses in most properties, except that less-than-unit length genome of ADV may be transcribed.

  20. Advanced Virgo

    CERN Multimedia

    Virgo, a first-generation interferometric gravitational wave (GW) detector, located in the European Gravitational Observatory, EGO, Cascina (Pisa-Italy) and constructed by the collaboration of French and Italian institutes (CNRS and INFN) has successfully completed its long-duration data taking runs. It is now undergoing a fundamental upgrade that exploits available cutting edges technology to open an exciting new window on the universe, with the first detection of a gravitational wave signal. Advanced Virgo (AdV) is the project to upgrade the Virgo detector to a second-generation instrument. AdV will be able to scan a volume of the Universe 1000 times larger than initial Virgo. AdV will be hosted in the same infrastructures as Virgo. The Advanced VIRGO project is funded and at present carried on by a larger collaboration of institutes belonging to CNRS- France , RMKI - Hungary, INFN- Italy, Nikhef - The Netherlands Polish Academy of Science - Poland.

  1. Comparative study of two extraction methods for enteric virus recovery from sewage sludge by molecular methods

    Directory of Open Access Journals (Sweden)

    AD Schlindwein

    2009-07-01

    Full Text Available The aim of this study was to compare two nucleic acid extraction methods for the recovery of enteric viruses from activated sludge. Test samples were inoculated with human adenovirus (AdV, hepatitis A virus (HAV, poliovirus (PV and rotavirus (RV and were then processed by an adsorption-elution-precipitation method. Two extraction methods were used: an organic solvent-based method and a silica method. The organic-based method was able to recoup 20% of the AdV, 90% of the RV and 100% of both the PV and HAV from seeded samples. The silica method was able to recoup 1.8% of the AdV and 90% of the RV. These results indicate that the organic-based method is more suitable for detecting viruses in sewage sludge.

  2. [Prophylaxis against respiratory viral disease in pediatric and adult patients undergoing solid organ and hematopoietic stem cells transplantation].

    Science.gov (United States)

    Álvarez, Ana M; Catalán, Paula; Alba, Andrea; Zubleta, Marcela

    2012-09-01

    Respiratory viruses have been identified as a cause of morbidity and mortality in patients undergoing SOT and HSCT, specially in children. The most frequent are respiratory syncytial virus (RSV), influenza (FLU), parainfluenza (PI) and adenovirus (ADV). These infections are associated with progression to severe lower respiratory tract infections in up to 60% of the cases. It is advised to apply universal protection recommendations for respiratory viruses (A2) and some specific measures for FLU and AD. FLU: Annual anti-influenza vaccination (from 4-6 months post-transplantation in SOT, 6 months in HSCT (A2)); post- exposure prophylaxis in FLU (oseltamivir for 10 days (B2)). In lung transplantion, the prophylaxis should last as long as the risk period (B2). ADV: There is no vaccine nor valid chemoprophylaxis strategy to prevent ADV disease. In some specific HSCT recipients, weekly PCR monitoring is recommended until day+100 (A3). PMID:23282554

  3. Shedding patterns of endemic Eurasian wild boar (Sus scrofa) pathogens.

    Science.gov (United States)

    González-Barrio, David; Martín-Hernando, María Paz; Ruiz-Fons, Francisco

    2015-10-01

    The Eurasianwild boar has experienced aworldwide demographic explosion that increases awareness on shared pathogens. However, shedding routes of relevant wild boar pathogens are unknown. Previous observations on sex- and age-related differences in Aujeszky's disease virus (ADV) exposure led us to hypothesize that shedding patterns of endemicwild boar pathogens may be influenced by individual traits.We investigated shedding routes of ADV, porcine parvovirus (PPV), porcine circovirus type 2 (PCV2) and Coxiella burnetii and analysed the effect of host sex and age on pathogen shedding patterns. The presence of pathogen antibodies in serumand of pathogen DNA in oral, nasal, genital and rectal swabswas analysed by ELISA and PCR, respectively. The influence of sex and age in pathogen shedding prevalencewas tested statistically.Main routes of ADV, PPV, PCV2 and C. burnetii shedding were identified but the hypothesis of sex- and/or age-related shedding patterns couldn't be confirmed. PMID:26412545

  4. Synthesis of amide derivatives of 6{alpha},7{beta}-di-hydroxyvouacapan-17{beta}-oic acid isolated from the Pterodon polygalaeflorus Benth fruits (leguminosae); Sintese de amidas derivadas do acido 6{alpha},7{beta}-di-hidroxivouacapan-17{beta}-oico isolado dos frutos de Pterodon polygalaeflorus Benth (leguminosae)

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, A.L.; Belinelo, V.J.; Stefani, G.M.; Pilo-Veloso, D. [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Dept. de Quimica]. E-mail: dorila@dedalus.lcc.ufmg.br; Reis, G.T. [Universidade de Itauna, MG (Brazil). Dept. de Ciencias; Ferreira-Alves, D.L. [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Dept. de Farmacologia

    2001-04-01

    Hydro-alcoholic infusions from fruits of Pterodon polygalaeflorus Benth, commonly known as 'Sucupira branca', are used in Brazilian folk medicine for rheumatic problems and throat infections. Since it has been verified that furanediterpene 6?,7?-di-hydroxyvouacapan-17?-oic acid (ADV), isolated from the hexane extract of these fruits presents anti-inflammatory, analgesic, and plant growth regulatory activity, a variety of ADV derivatives has been synthesized with the aim of obtaining more information about the structure-activity relationships of this series of compounds. In this work four new amide (4-7) derivatives of ADV have been synthesized. Their structures were established by spectroscopic data, including 2D-NMR methods. (author)

  5. Mechanical design and development of TES bolometer detector arrays for the Advanced ACTPol experiment

    CERN Document Server

    Ward, Jonathan T; Beall, James A; Choi, Steve K; Crowley, Kevin T; Devlin, Mark J; Duff, Shannon M; Gallardo, Patricio M; Henderson, Shawn W; Ho, Shuay-Pwu Patty; Hilton, Gene; Hubmayr, Johannes; Khavari, Niloufar; Klein, Jeffrey; Koopman, Brian J; Li, Dale; McMahon, Jeffrey; Mumby, Grace; Nati, Federico; Niemack, Michael D; Page, Lyman A; Salatino, Maria; Schillaci, Alessandro; Schmitt, Benjamin L; Simon, Sara M; Staggs, Suzanne T; Thornton, Robert; Ullom, Joel N; Vavagiakis, Eve M; Wollack, Edward J

    2016-01-01

    The next generation Advanced ACTPol (AdvACT) experiment is currently underway and will consist of four Transition Edge Sensor (TES) bolometer arrays, with three operating together, totaling ~5800 detectors on the sky. Building on experience gained with the ACTPol detector arrays, AdvACT will utilize various new technologies, including 150mm detector wafers equipped with multichroic pixels, allowing for a more densely packed focal plane. Each set of detectors includes a feedhorn array of stacked silicon wafers which form a spline profile leading to each pixel. This is then followed by a waveguide interface plate, detector wafer, back short cavity plate, and backshort cap. Each array is housed in a custom designed structure manufactured from high purity copper and then gold plated. In addition to the detector array assembly, the array package also encloses cryogenic readout electronics. We present the full mechanical design of the AdvACT high frequency (HF) detector array package along with a detailed look at t...

  6. Low field anisotropic colossal magnetoresistance in $Sm_{0.53} Sr_{0.47} Mn O_3$ thin films

    OpenAIRE

    Manoj K. Srivastava; Singh, M P; Kaur, Amarjeet; Razavi, F. S.; Singh, H.K.

    2013-01-01

    SSMO5347 thin films (thicknesses ~200 nm) were deposited by on-axis dc magnetron sputtering on the single crystal LSAT (001) substrates. These films are oriented along the out of plane c-direction. The ferromagnetic and insulator-metal transition occurs at 96 K and 91 K, respectively. The magnetization easy axis is observed to lie in the plane of the film while the magnetic hard axis is found to be along the normal to this. The magnetotransport of the SSMO films, which was measured as a funct...

  7. Asymptotic Spreading Fastened by Inter-Specific Coupled Nonlinearities: a Cooperative System

    CERN Document Server

    Lin, Guo

    2010-01-01

    This paper is concerned with the asymptotic spreading of a Lotka-Volterra cooperative system. Utilizing the theory developed by Berestycki et al. [Asymptotic spreading in heterogeneous diffusive excitable media, J. Funct. Anal. \\textbf{255} (2008), 2146-2189] for nonautonomous scalar equations, the lower bounds of spreading speeds of unknown functions formulated by a coupled system are estimated. Our results imply that the asymptotic spreading of one species can be significantly fastened by introducing a mutual species, which indicates the role of cooperation described by the coupled nonlinearities.

  8. Synthesis and characterization of a small analogue of the anticancer natural product leinamycin

    OpenAIRE

    Keerthi, Kripa; Rajapakse, Anuruddha; Sun, Daekyu; Gates, Kent S.

    2012-01-01

    Leinamycin (1) is a Streptomyces-derived natural product that displays nanomolar IC50 values against human cancer cell lines. In the work described here, we report the synthesis and characterization of a small leinamycin analogue 19 that closely resembles the “upper-right quadrant” of the natural product, consisting of an alicyclic 1,2-dithiolan-3-one 1-oxide heterocycle connected to an alkene by a two-carbon linker. The results indicate that this small analogue contains the core set of funct...

  9. m-Health smartphone applications on chronic disease monitoring : development and regulatory considerations

    OpenAIRE

    Li, Kit-ling, Carol; 李潔寧

    2014-01-01

    Introduction: The market for chronic disease management apps for patients is growing from year to year. However, policy and regulation of app use for medical purposes in Asia Pacific are not developed. Methods: 1) A systematic review of randomized-controlled trials of diabetes management apps for patients are assessed as to determine whether using the app (intervention group) leads to significant reductions in HbA1c levels ; 2) A comparison of paid and free apps based on number of group funct...

  10. Trajectory analysis for the nucleus and dust of comet C/2013~A1 (Siding Spring)

    OpenAIRE

    Farnocchia, Davide; Chesley, Steven R.; Chodas, Paul W.; Tricarico, Pasquale; Kelley, Michael S. P.; Farnham, Tony L.

    2014-01-01

    Comet C/2013 A1 (siding Spring) will experience a high velocity encounter with Mars on October 19, 2014 at a distance of 135,000 km +- 5000 km from the planet center. We present a comprehensive analysis of the trajectory of both the comet nucleus and the dust tail. The nucleus of C/2013 A1 cannot impact on Mars even in the case of unexpectedly large nongravitational perturbations. Furthermore, we compute the required ejection velocities for the dust grains of the tail to reach Mars as a funct...

  11. Temperature dependent resistance of magnetic tunnel junctions as a quality proof of the barrier

    OpenAIRE

    Rüdiger, Ulrich; Calarco, Raffaella; May, Ulrich; Samm, K.; Hauch, Jan O.; Kittur, Harish; Sperlich, Martin; Güntherodt, Gernot

    2001-01-01

    Tunnel junctions of Co(10 nm)/AlOx (nominally 2 nm)/Co(20 nm) have been prepared by molecular beam epitaxy applying a shadow mask technique in conjunction with an UV light-assisted oxidation process of the AlOx barrier. The quality of the AlOx barrier has been proven by x-ray photoelectron spectroscopy and temperature dependent tunneling magnetoresistance (TMR) measurements. Optimum-oxidized tunnel junctions show a TMR of 20% at 285 K and up to 36% at 100 K. At 285 K the TMR values as a funct...

  12. On Some Expansion Theorems Involving Confluent Hypergeometric $_{2}F_{2}(x)$ Polynomial

    OpenAIRE

    Vyas, Yashoverdhan; Fatawat, Kalpana

    2016-01-01

    Recently, Rathie and K{\\i}l{\\i}\\c{c}man (2014) employed Kummer-type transformation for $_{2}F_{2}(a, d+1; b, d; x)$ to develop certain classes of expansions theorems for $_{2}F_{2}(x)$ hypergeometric polynomial. Our aim is to deduce Kummer-type transformation for $_{2}F_{2}(a, d+2; b, d; x)$ and utilize it to develop some new expansion theorems for the confluent hypergeometric $_{2}F_{2}(x)$ polynomial. We also obtain a well-known result given by Kim et al. (Integral Transforms Spec. Funct. 2...

  13. SOSYAL AMAÇ BAĞLANTILI PAZARLAMA KAMPANYALARINDA SOSYAL AMAÇ VE MARKA UYUMUNUN TÜKETİCİLERİN KURUMSAL SOSYAL SORUMLULUK ALGILAMALARINA ETKİSİ

    OpenAIRE

    ÇAKIR,  HİLAL ÖZDEMİR

    2013-01-01

    The aim of this study is to analyse the influence of cause-brand fit on corporate social responsibility consumer perception in cause related marketing campaigns, that is one of the corporate social responsibility initiatives. In this context, the effects of two kinds of cause-brand fit; that are functional fit and image fit; is discussed. The study is supported by a research on Nivea brand; that is one of the leading brands of cosmetics sector. The results of the research show that both funct...

  14. The quark orbital angular momentum from Wigner distributions and light-cone wave functions

    OpenAIRE

    Lorce, Cédric; Pasquini, Barbara; Xiong, Xiaonu; Yuan, Feng

    2012-01-01

    We investigate the quark orbital angular momentum of the nucleon in the absence of gauge-field degrees of freedom, by using the concept of the Wigner distribution and the light-cone wave functions of the Fock state expansion of the nucleon. The quark orbital angular momentum is obtained from the phase-space average of the orbital angular momentum operator weighted with the Wigner distribution of unpolarized quarks in a longitudinally polarized nucleon. We also derive the light-cone wave funct...

  15. REGULATION OF PHOTOSYNTHESIS IN SORGHUM IN RESPONSE TO DROUGHT

    OpenAIRE

    Ogbaga, Chukwuma

    2014-01-01

    Changing climate in combination with growing world populations mean that there is growing need for plants to be grown on land that is currently considered marginal for agriculture. Sorghum is a C4 plant that serves as an important food crop in Africa and India. It is also known to be highly drought tolerant but the mechanisms responsible for this tolerance are unclear. The overall aim of this study was to understand the drought tolerance mechanisms that enable the plant to maintain leaf funct...

  16. Neutrino-nucleon cross sections at energies of Megaton-scale detectors

    OpenAIRE

    Gazizov A.; Kowalski M.; Kuzmin K.S.; Naumov V. A.; Spiering Ch.

    2016-01-01

    An updated set of (anti)neutrino-nucleon charged and neutral current cross sections at 3 GeV ≲ Eν ≲100 GeV is presented. These cross sections are of particular interest for the detector optimization and data processing and interpretation in the future Megaton-scale experiments like PINGU, ORCA, and Hyper-Kamiokande. Finite masses of charged leptons and target mass corrections in exclusive and deep inelastic (ν̅)νN interactions are taken into account. A new set of QCD NNLO parton density funct...

  17. Lectures on ordinary differential equations

    CERN Document Server

    Hurewicz, Witold

    2014-01-01

    Hailed by The American Mathematical Monthly as ""a rigorous and lively introduction,"" this text explores a topic of perennial interest in mathematics. The author, a distinguished mathematician and formulator of the Hurewicz theorem, presents a clear and lucid treatment that emphasizes geometric methods. Topics include first-order scalar and vector equations, basic properties of linear vector equations, and two-dimensional nonlinear autonomous systems. Suitable for senior mathematics students, the text begins with an examination of differential equations of the first order in one unknown funct

  18. 3-Adic Cantor function on local fields and its p-adic derivative

    International Nuclear Information System (INIS)

    The problem of 'rate of change' for fractal functions is a very important one in the study of local fields. In 1992, Su Weiyi has given a definition of derivative by virtue of pseudo-differential operators [Su W. Pseudo-differential operators and derivatives on locally compact Vilenkin groups. Sci China [series A] 1992;35(7A):826-36. Su W. Gibbs-Butzer derivatives and the applications. Numer Funct Anal Optimiz 1995;16(5 and 6):805-24. [2,3

  19. On the Principle of Optimality for Nonstationary Deterministic Dynamic Programming

    OpenAIRE

    Takashi Kamihigashi

    2007-01-01

    This note studies a general nonstationary infinite-horizon optimization problem in discrete time. We allow the state space in each period to be an arbitrary set, and the return function in each period to be unbounded. We do not require discounting, and do not require the constraint correspondence in each period to be nonempty-valued. The objective function is defined as the limit superior or inferior of the finite sums of return functions. We show that the sequence of time-indexed value funct...

  20. Towards precise calculation of transport coefficients in the hadron gas. The shear and the bulk viscosities

    OpenAIRE

    Moroz, Oleg N.

    2011-01-01

    The shear and the bulk viscosities of the hadron gas at low temperatures are studied in the model with constant elastic cross sections being relativistic generalization of the hard spheres model. One effective radius ${r=0.4 fm}$ is chosen for all elastic collisions. Only elastic collisions are considered which are supposed to be dominant at temperatures ${T\\leq 120-140 MeV}$. The calculations are done in the framework of the Boltzmann equation with the Boltzmann statistics distribution funct...

  1. Hacia una psicología social comunitaria

    OpenAIRE

    Gerardo Marín

    1980-01-01

    Either as a functíon of the críses in social psychology or as function of the needs for relevance in the area, contemporary social psychology is seen as moving into a "comunity social psychology". In this sense the ocial psychologist is ínterested in applying social-psychological knowledge in order to build from within thecommtinity. The role of the community social psychologist is seen as (a) measuring the community´s needs, (b) designíng the intervantíon that will produce ...

  2. Kernel smoothing in Matlab theory and practice of kernel smoothing

    CERN Document Server

    Horova, Ivanka; Zelinka, Jiri

    2012-01-01

    Methods of kernel estimates represent one of the most effective nonparametric smoothing techniques. These methods are simple to understand and they possess very good statistical properties. This book provides a concise and comprehensive overview of statistical theory and in addition, emphasis is given to the implementation of presented methods in Matlab. All created programs are included in a special toolbox which is an integral part of the book. This toolbox contains many Matlab scripts useful for kernel smoothing of density, cumulative distribution function, regression function, hazard funct

  3. Cross-sectional associations between prevalent vertebral fracture and pulmonary function. The sixth Tromso Study

    OpenAIRE

    Morseth, Bente; Melbye, Hasse; Waterloo, Svanhild Haugnes; Thomassen, Marte Renate; Risberg, Marijke Jongsma; Emaus, Nina

    2013-01-01

    Background Persons with vertebral fracture may have reduced pulmonary function, but this association has not been much studied. The aim of this cross-sectional study was therefore to examine the relationship between vertebral fracture and pulmonary function in a general, elderly population. Methods Vertebral morphometry was used for vertebral fracture assessment in 2132 elderly men (n = 892) and women (n = 1240) aged 55 to 87 years in the population-based Tromsø Study 2007–08. Pulmonary funct...

  4. Predicting Nonresponse Bias from Teacher Ratings of Mental Health Problems in Primary School Children

    OpenAIRE

    Stormark, Kjell Morten; Heiervang, Einar; Heimann, Mikael; Lundervold, Astri; Gillberg, Christopher

    2008-01-01

    The impact of nonresponse on estimates of mental health problems was examined in a prospective teacher screen in a community survey of 9,155 7–9 year olds. For 6,611 of the children, parents consented to participation in the actual study (Responders), while for 2,544 children parental consent was not obtained (Nonresponders). The teacher screen involved assessment of a broad set of symptoms of mental health problems and functional impairment. Calculations of non-response coefficients, a funct...

  5. Exercise tolerance testing in a cardiac rehabilitation setting: an exploratory study of its safety and practicality for exercise prescription and outcome data collection

    OpenAIRE

    Simms, Kay; Myers, Chris; Adams, Jenny; Hartman, Julie; Lindsey, Christopher; Doler, Mike; Suhr, Janet

    2007-01-01

    An exercise test is a valuable tool that should be a part of every patient's assessment before beginning cardiac rehabilitation. We analyzed data from one exercise tolerance test used in a cardiac rehabilitation program among 103 subjects: 65 men with a mean age of 60.5 years and 38 women with a mean age of 62.4 years. Resultsindicated that, after cardiac rehabilitation, subjects had significantimprovementin maximum metabolic equivalents (an increase of 0.9, P < 0.0001), which indicates funct...

  6. Effect of Cardiac Rehabilitation Program on Exercise Capacity in Women Undergoing Coronary Artery Bypass Graft in Hamadan-Iran

    OpenAIRE

    Ramin Shabani; Abas A Gaeini; Nikoo, Mohamad R.; Hojatollah Nikbackt; Majid Sadegifar

    2010-01-01

    Objectives: The purpose of this study was to determine the effects of cardiac rehabilitation program (CRP) on exercise capacity and rate pressure product (RPP) in Iranian female patients undergoing coronary artery bypass grafting (CABG) in Hamadan, Iran. Methods: Sixty women after CABG were assigned into an exer-cise group (n = 30, mean age 58.5 ± 10.8 years), who performed physical training for 12 weeks, or a control group (n = 30, mean age 59.3 ± 8.6 years) who received usual care. Funct...

  7. Differential Roles of the TRAF3 Adapter Protein in Adipogenesis and Glucose Metabolism

    OpenAIRE

    Loo, Lotus Kyi

    2015-01-01

    The main goal of this project is to delineate the roles and mechanisms of constitutive type II nuclear factor-kappa B (NF-kB) activation on adipogenesis and glucose metabolism. Our laboratory has shown that the tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) is a critical negative modulator of type II NF-kB and TRAF3 knockout (TRAF3-/-) have constitutive activation of non canonical or type II NF-kB pathway. However, TRAF3-/- pups die within two weeks after birth and the funct...

  8. Consumer Confidence and Elections

    OpenAIRE

    Hardouvelis, Gikas A; Dimitrios D. Thomakos

    2008-01-01

    We investigate the behavior of consumer confidence around national elections in the EU-15 countries during 1985:1-2007:3. Consumer confidence increases before the date of elections and falls subsequently by almost the same amount. It is able to predict the strength of the performance of the incumbent party and its probability of re-election both alone and in the presence of macro- economic and fiscal variables. The post-election drop is negatively related to the previous run up and is a funct...

  9. Arterial function of carotid and brachial arteries in postmenopausal vegetarians

    OpenAIRE

    Su, Ta-Chen

    2011-01-01

    Ta-Chen Su1, Pao-Ling Torng2, Jiann-Shing Jeng3, Ming-Fong Chen1, Chiau-Suong Liau1,41Division of Cardiology, Department of Internal Medicine, 2Department of Obstetrics and Gynecology, 3Department of Neurology, National Taiwan University Hospital, National Taiwan University College of Medicine, 4Cardiovascular Center, Taipei Buddist Tzu-Chi Hospital, Hsin-Dian, Taipei, TaiwanBackground: Vegetarianism is associated with a lower risk of cardiovascular disease. However, studies of arterial funct...

  10. First, Scale Up to the Robotic Turing Test, Then Worry About Feeling

    OpenAIRE

    Harnad, Stevan; Scherzer, Peter

    2007-01-01

    Consciousness is feeling, and the problem of consciousness is the problem of explaining how and why some of the functions underlying some of our performance capacities are felt rather than just “functed.” But unless we are prepared to assign to feeling a telekinetic power (which all evidence contradicts), feeling cannot be assigned any causal power at all. We cannot explain how or why we feel. Hence the empirical target of cognitive science can only be to scale up to the robotic Turing Test, ...

  11. First, scale up to the robotic Turing test, then worry about feeling.

    Science.gov (United States)

    Harnad, Stevan; Scherzer, Peter

    2008-10-01

    Consciousness is feeling, and the problem of consciousness is the problem of explaining how and why some of the functions underlying some of our performance capacities are felt rather than just "functed." But unless we are prepared to assign to feeling a telekinetic power (which all evidence contradicts), feeling cannot be assigned any causal power at all. We cannot explain how or why we feel. Hence the empirical target of cognitive science can only be to scale up to the robotic Turing test, which is to explain all of our performance capacity, but without explaining consciousness or incorporating it in any way in our functional explanation. PMID:18930641

  12. Unique Case Reports Associated with Ovarian Failure: Necessity of Two Intact X Chromosomes

    OpenAIRE

    Baidyanath Chakraborthy; Pratibha Nallari; Prasun Deb; Nalini Gupta; Bipin Kumar Sethi; Mamata Deenadayal; Kattera Himaja; Govindaraghavan Saranaya; Metuku Vidyadhari; Mangalipally Swapna; Raseswari Turlapati; Murthy Kanakavalli; Venkata Padmalatha; Lakshmi Rao Kandukuri; Lalji Singh

    2012-01-01

    Premature ovarian failure is defined as the loss of functional follicles below the age of 40 years and the incidence of this abnormality is 0.1% among the 30–40 years age group. Unexplained POF is clinically recognized as amenorrhoea (>6 months) with low level of oestrogen and raised level of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH > 20 IU/l) occurring before the age of 40. It has been studied earlier that chromosomal defects can impair ovarian development and its funct...

  13. Localization lemmas for the Bergman metric at plurisubharmonic peak points

    OpenAIRE

    Herbort, Gregor

    2003-01-01

    Let $D$ be a bounded pseudoconvex domain in $\\CC^n$ and $\\zeta \\in \\d D$. By $K_D$ and $B_D$ we denote the Bergman kernel and metric of $D$, respectively. Given a ball $B=B(\\zeta, R)$, we study the behavior of the ratio $K_D/K_{D\\cap B} (w)$ when $w\\in D\\cap B$ tends towards $\\zeta$. It is well-known, that it remains bounded from above and below by a positive constant. We show, that the ratio tends to $1$, as $w$ tends to $\\zeta$, under an additional assumption on the pluricomplex Green funct...

  14. Mesenchymal stem cells as carriers and amplifiers in CRAd delivery to tumors

    Directory of Open Access Journals (Sweden)

    Wei Junchen

    2011-11-01

    Full Text Available Abstract Background Mesenchymal stem cells (MSCs have been considered to be the attractive vehicles for delivering therapeutic agents toward various tumor diseases. This study was to explore the distribution pattern, kinetic delivery of adenovirus, and therapeutic efficacy of the MSC loading of E1A mutant conditionally replicative adenovirus Adv-Stat3(- which selectively replicated and expressed high levels of anti-sense Stat3 complementary DNA in breast cancer and melanoma cells. Methods We assessed the release ability of conditionally replicative adenovirus (CRAd from MSC using crystal violet staining, TCID50 assay, and quantitative PCR. In vitro killing competence of MSCs carrying Adv-Stat3(- toward breast cancer and melanoma was performed using co-culture system of transwell plates. We examined tumor tropism of MSC by Prussian blue staining and immunofluorescence. In vivo killing competence of MSCs carrying Adv-Stat3(- toward breast tumor was analyzed by comparison of tumor volumes and survival periods. Results Adv-Stat3(- amplified in MSCs and were released 4 days after infection. MSCs carrying Adv-Stat3(- caused viral amplification, depletion of Stat3 and its downstream proteins, and led to significant apoptosis in breast cancer and melanoma cell lines. In vivo experiments confirmed the preferential localization of MSCs in the tumor periphery 24 hours after tail vein injection, and this localization was mainly detected in the tumor parenchyma after 72 hours. Intravenous injection of MSCs carrying Adv-Stat3(- suppressed the Stat3 pathway, down-regulated Ki67 expression, and recruited CD11b-positive cells in the local tumor, inhibiting tumor growth and increasing the survival of tumor-bearing mice. Conclusions These results indicate that MSCs migrate to the tumor site in a time-dependent manner and could be an effective platform for the targeted delivery of CRAd and the amplification of tumor killing effects.

  15. Random sampling of the Central European bat fauna reveals the existence of numerous hitherto unknown adenoviruses.

    Science.gov (United States)

    Vidovszky, Márton; Kohl, Claudia; Boldogh, Sándor; Görföl, Tamás; Wibbelt, Gudrun; Kurth, Andreas; Harrach, Balázs

    2015-12-01

    From over 1250 extant species of the order Chiroptera, 25 and 28 are known to occur in Germany and Hungary, respectively. Close to 350 samples originating from 28 bat species (17 from Germany, 27 from Hungary) were screened for the presence of adenoviruses (AdVs) using a nested PCR that targets the DNA polymerase gene of AdVs. An additional PCR was designed and applied to amplify a fragment from the gene encoding the IVa2 protein of mastadenoviruses. All German samples originated from organs of bats found moribund or dead. The Hungarian samples were excrements collected from colonies of known bat species, throat or rectal swab samples, taken from live individuals that had been captured for faunistic surveys and migration studies, as well as internal organs of dead specimens. Overall, 51 samples (14.73%) were found positive. We detected 28 seemingly novel and six previously described bat AdVs by sequencing the PCR products. The positivity rate was the highest among the guano samples of bat colonies. In phylogeny reconstructions, the AdVs detected in bats clustered roughly, but not perfectly, according to the hosts' families (Vespertilionidae, Rhinolophidae, Hipposideridae, Phyllostomidae and Pteropodidae). In a few cases, identical sequences were derived from animals of closely related species. On the other hand, some bat species proved to harbour more than one type of AdV. The high prevalence of infection and the large number of chiropteran species worldwide make us hypothesise that hundreds of different yet unknown AdV types might circulate in bats. PMID:26599097

  16. The Role of Major Gas-rich Mergers on the Evolution of Galaxies from the Blue Cloud to the Red Sequence

    Science.gov (United States)

    Guo, Rui; Hao, Cai-Na; Xia, X. Y.; Mao, Shude; Shi, Yong

    2016-07-01

    With the aim of exploring the fast evolutionary path from the blue cloud of star-forming galaxies to the red sequence of quiescent galaxies in the local universe, we select a local advanced merging infrared luminous and ultraluminous galaxy (adv-merger (U)LIRGs) sample and perform careful dust extinction corrections to investigate their positions in the star formation rate–M *, u ‑ r, and NUV ‑ r color–mass diagrams. The sample consists of 89 (U)LIRGs at the late merger stage, obtained from cross-correlating the Infrared Astronomical Satellite Point Source Catalog Redshift Survey and 1 Jy ULIRGs samples with the Sloan Digital Sky Survey DR7 database. Our results show that 74 % +/- 5 % of adv-merger (U)LIRGs are localized above the 1σ line of the local star-forming galaxy main sequence. We also find that all adv-merger (U)LIRGs are more massive than and as blue as the blue cloud galaxies after corrections for Galactic and internal dust extinctions, with 95 % +/- 2 % and 81 % +/- 4 % of them outside the blue cloud on the u ‑ r and NUV ‑ r color–mass diagrams, respectively. These results, combined with the short timescale for exhausting the molecular gas reservoir in adv-merger (U)LIRGs (3× {10}7 to 3× {10}8 years), imply that the adv-merger (U)LIRGs are likely at the starting point of the fast evolutionary track previously proposed by several groups. While the number density of adv-merger (U)LIRGs is only ∼ 0.1 % of the blue cloud star-forming galaxies in the local universe, this evolutionary track may play a more important role at high redshift.

  17. Synergistic tumor suppression by adenovirus-mediated ING4/PTEN double gene therapy for gastric cancer.

    Science.gov (United States)

    Zhang, H; Zhou, X; Xu, C; Yang, J; Xiang, J; Tao, M; Xie, Y

    2016-01-01

    Both inhibitor of growth 4 (ING4) and phosphatase and tensin homolog (PTEN) have been shown to be strong candidate tumor suppressors. However, the combined efficacy of ING4 and PTEN for human gastric cancer remains to be determined. In this report, we constructed a multiple promoter expression cassette-based recombinant adenovirus coexpressing ING4 and PTEN (AdVING4/PTEN), assessed the combined effects of AdVING4/PTEN on gastric cancer using wild-type p53 AGS and SNU-1 human gastric cancer cell lines, and elucidated its underlying mechanisms. We found that AdVING4/PTEN-induced synergistic growth inhibition and apoptosis in vitro AGS or SNU-1 tumor cells and in vivo AGS xenografted tumors subcutaneously inoculated in athymic BALB/c nude mice. Mechanistically, AdVING4/PTEN exhibited an enhanced effect on upregulation of p53, Ac-p53 (K382), P21, Bax, PUMA, Noxa, cleaved Caspase-9, cleaved Caspase-3 and cleaved PARP as well as downregulation of Bcl-2 in vitro and in vivo. In addition, AdVING4/PTEN synergistically downregulated tumor vessel CD34 expression and reduced microvessel density, and additively inhibited vascular endothelial growth factor (VEGF) expression in vivo. The synergistic tumor suppression elicited by AdVING4/PTEN was closely associated with the synergistic induction of apoptosis possibly via enhancement of endogenous p53 responses through cooperatively facilitating p53's stability and acetylation, and the synergistic inhibition of tumor angiogenesis probably via overlapping reduction of VEGF through cooperatively downregulating hypoxia inducible factor-1α's level and transcription activity. Thus, our results indicate that cancer gene therapy combining ING4 and PTEN may constitute a novel and effective therapeutic modality for human gastric cancer and other cancers. PMID:26564429

  18. Effect of self-interstitial diffusion anisotropy in electron-irradiated zirconium: A cluster dynamics modeling

    Science.gov (United States)

    Christien, F.; Barbu, A.

    2005-11-01

    A model based on the cluster dynamics approach was proposed in [A. Hardouin Duparc, C. Moingeon, N. Smetniansky-de-Grande, A. Barbu, J. Nucl. Mater. 302 (2002) 143] to describe point defect agglomeration in metals under irradiation. This model is restricted to materials where point defect diffusion is isotropic and is thus not applicable to anisotropic metals such as zirconium. Following the approach proposed by Woo [C.H. Woo, J. Nucl. Mater. 159 (1988) 237], we extended in this work the model to the case where self-interstitial atoms (SIA) diffusion is anisotropic. The model was then applied to the loop microstructure evolution of a zirconium thin foil irradiated with electrons in a high-voltage microscope. First, the inputs were validated by comparing the numerical results with Hellio et al. experimental results [C. Hellio, C.H. de Novion, L. Boulanger, J. Nucl. Mater. 159 (1988) 368]. Further calculations were made to evidence the effect of the thin foil orientation on the dislocation loop microstructure under irradiation. The result is that it is possible to reproduce for certain orientations the 'unexpected' vacancy loop growth experimentally observed in electron-irradiated zirconium [M. Griffiths, M.H. Loretto, R.E. Sallmann, J. Nucl. Mater. 115 (1983) 313; J. Nucl. Mater. 115 (1983) 323; Philos. Mag. A 49 (1984) 613]. This effect is directly linked to SIA diffusion anisotropy.

  19. Effect of self-interstitial diffusion anisotropy in electron-irradiated zirconium: A cluster dynamics modeling

    Energy Technology Data Exchange (ETDEWEB)

    Christien, F. [Service de Recherches de Metallurgie Physique, CEA Saclay, 91191 Gif-sur-Yvette cedex (France)]. E-mail: frederic.christien@polytech.univ-nantes.fr; Barbu, A. [Service de Recherches de Metallurgie Physique, CEA Saclay, 91191 Gif-sur-Yvette cedex (France)

    2005-11-15

    A model based on the cluster dynamics approach was proposed in [A. Hardouin Duparc, C. Moingeon, N. Smetniansky-de-Grande, A. Barbu, J. Nucl. Mater. 302 (2002) 143] to describe point defect agglomeration in metals under irradiation. This model is restricted to materials where point defect diffusion is isotropic and is thus not applicable to anisotropic metals such as zirconium. Following the approach proposed by Woo [C.H. Woo, J. Nucl. Mater. 159 (1988) 237], we extended in this work the model to the case where self-interstitial atoms (SIA) diffusion is anisotropic. The model was then applied to the loop microstructure evolution of a zirconium thin foil irradiated with electrons in a high-voltage microscope. First, the inputs were validated by comparing the numerical results with Hellio et al. experimental results [C. Hellio, C.H. de Novion, L. Boulanger, J. Nucl. Mater. 159 (1988) 368]. Further calculations were made to evidence the effect of the thin foil orientation on the dislocation loop microstructure under irradiation. The result is that it is possible to reproduce for certain orientations the 'unexpected' vacancy loop growth experimentally observed in electron-irradiated zirconium [M. Griffiths, M.H. Loretto, R.E. Sallmann, J. Nucl. Mater. 115 (1983) 313; J. Nucl. Mater. 115 (1983) 323; Philos. Mag. A 49 (1984) 613]. This effect is directly linked to SIA diffusion anisotropy.

  20. Role of Diatoms in marine biofouling

    Digital Repository Service at National Institute of Oceanography (India)

    Anil, A.C.; Patil, J.S..; Mitbavkar, S.; DeCosta, P.M.; DeSilva, S.; Hegde, S.; Naik, R.

    stream_size 43119 stream_content_type text/plain stream_name Recent_Adv_Appl_Aspects_Indian_Mar_Algae_2006_1_351.pdf.txt stream_source_info Recent_Adv_Appl_Aspects_Indian_Mar_Algae_2006_1_351.pdf.txt Content-Encoding ISO-8859...-1 Content-Type text/plain; charset=ISO-8859-1 Recent Advances on Applied Aspects of Indian Marine Algae with Reference to Global Scenario, Volume 1, A. Tewari (Ed.), 2006 Central Salt & Marine Chemicals Research Institute Role of Diatoms...

  1. Cloning and expression of Aujeszky's disease virus glycoprotein E (gE) in a baculovirus system Clonagem e expressão da glicoproteina E (gE) do vírus da doença de Aujeszky em sistema de baculovirus

    OpenAIRE

    Régia Maria Feltrin Dambros; Bergman Moraes Ribeiro; Aguiar, Raimundo Wagner de S.; Rejane Schaefer; Paulo Augusto Esteves; Simone Perecmanis; Neide Lisiane Simon; Nayara Cavalcante Silva; Michele Coldebella; Janice Reis Ciacci-Zanella

    2007-01-01

    Aujeszky' s disease (AD) is an infectious disease causing important economic losses to the swine industry worldwide. The disease is caused by an alpha-herpesvirus, Aujeszky' s disease virus (ADV), an enveloped virus with a double stranded linear DNA genome. The ADV genome encodes 11 glycoproteins, which are major targets for the immune system of the host in response to the infection. The glycoprotein E (gE) is a non-essential protein and deletion of the gE gene has been used for the productio...

  2. [Investigation of adenovirus isolation frequency from the stool samples of patients suspected with acute flaccid paralysis].

    Science.gov (United States)

    Bayrakdar, Fatma; Coşgun, Yasemin; Salman Atak, Tunca; Karademir, Hülya; Korukluoğlu, Gülay

    2016-04-01

    Although adenoviruses (AdVs) generally cause upper respiratory tract infections, conjunctivitis/epidemic keratoconjunctivitis, gastroenteritis and pneumonia, they can lead to the involvement of central nervous system. Acute flaccid paralysis (AFP) is a type of seizure, characterized by rapid and sudden onset of extreme weakness in hands and feet, including (less frequently) weakness of respiratory and swallowing, representing with decreased muscle tone, especially in children below 15-year-old. The major viral cause of AFP is polioviruses, however non-polio enteroviruses, mumps virus, rabies virus and flaviviruses can also be responsible for AFP. The data of some recent studies have pointed out the probable aetiological role of AdVs in AFP. The aim of this study was to investigate the frequency of AdVs from stool samples of AFP-suspected patients and their contacts. A total of 6130 stool samples from patients (age range: 0-15 years) prediagnosed as AFP (n= 3185) and their contacts (n= 2945), which were sent to our laboratory from the health care centers located at different regions of Turkey for the monitorization of poliomyelitis as part of national AFP surveillance programme, between 2000-2014, have been retrospectively evaluated in terms of adenovirus isolation frequency. Samples were analyzed according to the algorithm recommended by World Health Organization and inoculated in Hep-2, RD, and L20B cell lines for cultivation. Apart from enteroviruses, in case of the presence of characteristic cytopathic effects for AdVs observed in L20B cells were confirmed by a commercial Adeno agglutination kit (Diarlex Adeno; Orion Diagnostica, Finland). It was noted that AdVs have been isolated from 1.6% (97/6130) of the samples, and out of positive samples 76.3% (74/97) were from AFP-suspected cases, while 23.7% (23/97) were from their contacts. Accordingly the frequencies of AdVs from AFP-suspected cases and their contacts were found as 2.3% (74/3185) and 0.8% (23

  3. Quantitative Real-Time PCR Assays for Detection of Human Adenoviruses and Identification of Serotypes 40 and 41

    OpenAIRE

    Jothikumar, Narayanan; Cromeans, Theresa L.; Hill, Vincent R.; Lu, Xiaoyan; Sobsey, Mark D.; Erdman, Dean D.

    2005-01-01

    A quantitative real-time TaqMan PCR assay for detection of human adenoviruses (HAdV) was developed using broadly reactive consensus primers and a TaqMan probe targeting a conserved region of the hexon gene. The TaqMan assay correctly identified 56 representative adenovirus prototype strains and field isolates from all six adenovirus species (A to F). Based on infectious units, the TaqMan assay was able to detect as few as 0.4 and 0.004 infectious units of adenovirus serotype 2 (AdV2) and AdV4...

  4. Analysis of linguistic terms of variables representing the wave of arterial diameter variation in radial arteries using fuzzy entropies

    International Nuclear Information System (INIS)

    In this work we use 53 Arterial Diameter Variation (ADV) waves extracted from radial artery of normotense males, along with the values of variables that represent the ADV wave, obtained by means of multivariate analysis. Then, we specify the linguistic variables and the linguistic terms. The variables are fuzzified using triangular and trapezoidal fuzzy numbers. We analyze the fuzziness of the linguistic terms by applying discrete and continuous fuzzy entropies. Finally, we infer which variable presents the greatest disorder associated to the loss of arterial elasticity in radial artery

  5. Inhibition of viral protein r on human colorectal cancer cells and the possible mechanisms%Vpr对人结肠癌细胞的抑制作用及其机制

    Institute of Scientific and Technical Information of China (English)

    马波; 张汉超; 徐新女; 张飚; 王金环

    2012-01-01

    Objective To investigate the inhibitive effects of viral protein r (Vpr) of human immunodeficiency virus 1 ( HIV-1 ) on human colorectal cancer cell line HCT-8,and to find the possible mechanisms.Methods The HCT-8 cells were divided into the control group,adv group and adv-Vpr group.HCT-8 cells were not treated in the control group; HCT-8 cells were treated with Adv or Adv-Vpr at different multiplicity of infection (MOI) in the Adv group or Adv-Vpr group,respectively.Cell proliferation was detected by MTT assay.Cell cycle,apoptosis and mitochondrial membrane potential were detected by flow cytometry.The expression of apoptosisrelated proteins was detected by Western blot.All data were analyzed by using the q test,t test and one-way or two-way analysis of variance.Results The proliferation of HCT-8 cells was significantly inhibited by Vpr.The MTT value of HCT- 8 cells in the Adv-Vpr group was 1.03 ± 0.04,which was significantly lower than 2.46 ± 0.15 in the Adv group and 2.51 ± 0.14 in the control group at 72 hours after Adv-Vpr transfection ( MOI =200) ( F =144.6,P < 0.05).The ratio of HCT-8 cells in the G2/M phase was 37.31% ± 5.90% in the Adv-Vpr group,which was significantly higher than 18.30% ± 6.04% in the Adv group and 16.66% ± 3.51% in the control group ( F =10.08,P < 0.05 ).The ratio of HCT-8 cells with decreased mitochondrial membrane potential was 32.07% ±5.64% in the Adv-Vpr group,which was significantly higher than 3.32% ±0.79% in the Adv group and 2.76% ±1.43 % in the control group at 48 hours after Adv-Vpr transfection ( MOI =200) ( F =64.45,P < 0.05).The apoptosis rate of HCT-8 cells was 37.62% ±6.48% in the Adv-Vpr group,which was significantly higher than 3.44% ± 1.11% in the Adv group and 2.93% ± 1.07% in the control group at 72 hours after Adv-Vpr transfection ( MOI =200) ( F =122.4,P < 0.05 ).The results of Western blot showed that Vpr induced cleavage and activation of Caspase-9 and

  6. Dural administration of inflammatory soup or Complete Freund's Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion

    DEFF Research Database (Denmark)

    Lukács, M; Haanes, K A; Majláth, Zs;

    2015-01-01

    induces inflammatory activation in the trigeminal ganglion. METHODS: We performed topical administration of inflammatory soup (IS) or Complete Freund's Adjuvant (CFA) onto an exposed area of the rat dura mater in vivo for 20 min. The window was closed and the rats were sacrificed after 4 h and up to 7...... previously been shown that application of inflammatory or algesic substances onto the dura mater or chemical stimulation of the dural receptive fields causes hypersensitivity to mechanical and thermal stimulation together with direct activation of the TG. We asked whether local inflammation of dura mater...... days. Myography was performed on middle meningeal arteries. The trigeminal ganglia were removed and processed for immunohistochemistry or Western blot. RESULTS: Both CFA and IS induced enhanced expression of pERK1/2, IL-1β and CGRP in the trigeminal ganglia. The pERK1/2 immunoreactivity was mainly seen...

  7. Arachnoid granulations may control heat exchange between intracranial dural sinuses and cerebrospinal fluid

    Directory of Open Access Journals (Sweden)

    Abdullah Kaya

    2013-02-01

    Full Text Available Selective brain cooling is a system in a human that protects the brain from hyperthermia. Cool venous blood from head skin and upper respiratory tract drains into intracranial dural sinuses. In that region, cool blood in the dural sinuses decreases the temperature of the cerebrospinal fluid. Cerebrospinal fluid provides brain cooling. All cortical arteries to the brain pass the cerebrospinal fluid compartment. Also cerebrospinal fluid washes cortical nervous tissue. To provide optimal temperature for the brain cortex, heat exchange between cerebrospinal fluid and venous blood in dural sinuses should be well controlled. Head skin is in direct contact with the outside, and significant heat exchanges may occur within dural sinuses. A barrier made of dura mater and arachnoid mater has been proposed to transmit heat from dural sinuses to the cerebrospinal fluid. However, this barrier is a mechanical barrier and can’t optimize the temperature of cerebrospinal fluid. Also it has two laminas (dura mater and arachnoid mater and dura mater has a high vascularization. Therefore, this barrier may obstruct heat exchange. In this hypothetical paper, I offer arachnoid granulations as a functional barrier for heat exchange between blood in dural sinuses and cerebrospinal fluid. Arachnoid granulations are invaginations of arachnoid mater to the dural sinuses. Cerebrospinal fluid passes to the dural sinuses via arachnoid granulations. An arachnoid granulation provides a very thin wall between two compartments and may transmit heat effectively. Also arachnoid granulations may control cerebrospinal fluid flow to the dural sinuses according to temperature differences between two compartments. It is worth researching whether there are any functional or histological differences of the arachnoid granulations between people living in cold and hot places. There may also be an association between pathologies such as migraine and pseudotumor cerebri and this possible

  8. Bone autografts and allografts in dogs

    International Nuclear Information System (INIS)

    Three patients (1 dog, 2 horses) are described where myelography was complicated, purportedly by injection of contrast medium into the meninges superficial to the subarachnoid space, Contrast medium injected in this location in a cadaver tended to accumulate dorsally within the vertebral canal, deep to the dura mater but superficial to the subarachnoid space, The ventral margin of the pooled contrast medium had a wavy or undulating margin and the dorsal margin was smooth, pooled contrast medium was believed to be sequestered within the structurally weakdural border cell layer between the dura mater and arachnoid membrane, or the so-called subdural space

  9. Seroprevalence of Chlamydia abortus in camel in the western region of Libya

    Directory of Open Access Journals (Sweden)

    Rabia Elzlitne

    2016-06-01

    Conclusion: The present findings signify the C. abortus as a potential agent to cause abortion in Libyan camel (C. dromedarius. Besides, the persons who handle camels in Libya are at risk of infecting with C. abortus. [J Adv Vet Anim Res 2016; 3(2.000: 178-183

  10. Ectopic bone formation of human bone morphogenetic protein-2 gene transfected goat bone marrow-derived mesenchymal stem cells in nude mice

    Institute of Scientific and Technical Information of China (English)

    汤亭亭; 徐小良; 戴尅戎; 郁朝锋; 岳冰; 楼觉人

    2005-01-01

    Objective: To evaluate the osteogenic potential of bone morphogenetic protein (BMP)-2 gene transfected goat bone marrow-derived mesenchymal stem cells (MSCs). Methods: Goat bone marrow- derived MSCs were transfected by Adv-human bone morphogenetic protein (hBMP)-2 gene(Group 1), Adv-beta gal transfected MSCs (Group 2)and uninfected MSCs(Group 3). Western blot analysis, alkaline phosphatase staining, Von Kossa staining and transmission electron microscopy were adopted to determine the phenotype of MSCs. Then the cells were injected into thigh muscles of the nude mice. Radiographical and histological evaluations were performed at different intervals. Results: Only Adv-hBMP-2 transfected MSCs produced hBMP-2. These cells were positive for alkaline phosphatase staining at the 12th day and were positive for Von Kossa staining at the 16th day after gene transfer. Electron microscopic observation showed that there were more rough endoplasmic reticulum, mitochondria and lysosomes in Adv-hBMP-2 transfected MSCs compared to MSCs of other two groups. At the 3rd and 6th weeks after cell injection, ectopic bones were observed in muscles of nude mice of Group 1. Only fibrous tissue or a little bone was found in other two groups. Conclusions: BMP-2 gene transfected MSCs can differentiate into osteoblasts in vitro and induce bone formation in vivo.

  11. Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-hour glucose and insulin excursions

    Science.gov (United States)

    It has been proposed that the adverse metabolic effects of chronic consumption of sugar-sweetened beverages which contain both glucose and fructose are a consequence of increased circulating glucose and insulin excursions, i.e dietary glycemic index (GI). Objective: We determined if the greater adv...

  12. Face-subgroups of permutation polytopes

    OpenAIRE

    Haase, Christian

    2015-01-01

    In [Baumeister, H., Nill, Paffenholz, On permutation polytopes, Adv. Math. 222 (2009), 431-452 / arXiv:0709.1615] we conjectured a characterization of subgroups H of a permutation group G so that, on the level of permutation polytopes, P(H) is a face of P(G). Here we present the embarrassingly simple proof of this conjecture.

  13. Transportation scenario of Black Bengal goats in Gabtoli and Sirajganj markets of Bangladesh

    Directory of Open Access Journals (Sweden)

    Mohammed Nazmus sakib

    2016-03-01

    Conclusion: From this study it is concluded that Black Bengal goats became physically unfit during long time transportation although majority of the farmers took proper management practices. Therefore, changes in behavioral responses might be alleviated through creating awareness to animal raiser as well transporter. [J Adv Vet Anim Res 2016; 3(1.000: 38-44

  14. Pro-active environmental strategies,main source of competitive advantage within economic organizations

    OpenAIRE

    Oana-Catalina TÃPURICA; Florin TACHE

    2009-01-01

    Nowadays, contemporary organizations within Romanian economic environment are striving to reach the environmental and quality performance standards set up by the European Union, concerning the environmental protection and preservation. Under these circumstances, the organizations are highly recommended, especially those operating in high environmental impact economic sectors, to develop and implement proactive environmental strategies, as a main source to achieve a sustainable competitive adv...

  15. On the coevolution of social responsiveness and behavioural consistency

    NARCIS (Netherlands)

    Wolf, Max; Van Doorn, G. Sander; Weissing, Franz J.

    2011-01-01

    Recent research focuses on animal personalities, that is individual differences in behaviour that are consistent across contexts and over time. From an adaptive perspective, such limited behavioural plasticity is surprising, since a more flexible structure of behaviour should provide a selective adv

  16. Polyfluoroalkyl Chemicals in the Serum and Milk of Breastfeeding Women.

    Science.gov (United States)

    Polyfluoroalkyl chemicals (PFCs) comprise a group of man-made organic compounds, some of which are persistent contaminants with developmental toxicity shown in laboratory animals. There is a paucity of human perinatal exposure data. The US EPA conducted a pilot study (Methods Adv...

  17. 一种精确求解两相流动的界面追踪方法

    Institute of Scientific and Technical Information of China (English)

    孙东亮; 王丽; 徐进良

    2011-01-01

    本文提出了一种求解两相流动问题的精确稳定的界面追踪方法-ADV-VOF(accurate density and viscosity volume of fluid method).该方法具有以下特征:(1)基于同位网格系统;(2)使用PLIC方法捕捉界面和计算网格边界上精确的密度和粘度值;(3)采用守恒的Navier-scokes方程,其中对流项离散格式为有界高阶组合格式--STOIC;(4)应用分步算法求解守恒的Naviel-Stokes方程;(5)利用Bi-CGSTAB方法求解压力修正方程.以上特征保证了ADV-VOF方法是一种精确、稳定、高效、简便的界面追踪方法.最后我们对ADV-VOF方法和传统的IDV-VOF(inaccurate demity and viscosity volume of fluid method)方法进行了比较分析,得出ADV-VOF方法的性能远远优于传统的IDV-VOF方法.

  18. The efficiency of concentration methods used to detect enteric viruses in anaerobically digested sludge

    Directory of Open Access Journals (Sweden)

    Tatiana Prado

    2013-02-01

    Full Text Available The presence of enteric viruses in biosolids can be underestimated due to the inefficient methods (mainly molecular methods used to recover the viruses from these matrices. Therefore, the goal of this study was to evaluate the different methods used to recover adenoviruses (AdV, rotavirus species A (RVA, norovirus genogroup II (NoV GII and the hepatitis A virus (HAV from biosolid samples at a large urban wastewater treatment plant in Brazil after they had been treated by mesophilic anaerobic digestion. Quantitative polymerase chain reaction (PCR was used for spiking experiments to compare the detection limits of feasible methods, such as beef extract elution and ultracentrifugation. Tests were performed to detect the inhibition levels and the bacteriophage PP7 was used as an internal control. The results showed that the inhibitors affected the efficiency of the PCR reaction and that beef extract elution is a suitable method for detecting enteric viruses, mainly AdV from biosolid samples. All of the viral groups were detected in the biosolid samples: AdV (90%, RVA, NoV GII (45% and HAV (18%, indicating the viruses' resistance to the anaerobic treatment process. This is the first study in Brazil to detect the presence of RVA, AdV, NoV GII and HAV in anaerobically digested sludge, highlighting the importance of adequate waste management.

  19. Anti-reflux surgery - children - discharge

    Science.gov (United States)

    ... enable JavaScript. Your child had surgery to treat gastroesophageal reflux disease (GERD). GERD is a condition that causes acid, food, or ... IPEG guidelines for the surgical treatment of pediatric gastroesophageal reflux disease (GERD). J Laparoendosc Adv Surg Tech A . ...

  20. Review of Decoherence Free Subspaces, Noiseless Subsystems, and Dynamical Decoupling

    OpenAIRE

    Lidar, Daniel A.

    2012-01-01

    Comment: 34 pages, 4 figures. Based on lecture notes from a course on quantum error correction given by the author at USC in Spring 2007 and Fall 2011, 2013. Prepared for a special issue of Adv. Chem. Phys. on Quantum Information and Computation for Chemistry. v3: some parts rewritten for clarity, various corrections