WorldWideScience

Sample records for adv funct mater

  1. Carbon Nanotubes: Printed Carbon Nanotube Electronics and Sensor Systems (Adv. Mater. 22/2016).

    Science.gov (United States)

    Chen, Kevin; Gao, Wei; Emaminejad, Sam; Kiriya, Daisuke; Ota, Hiroki; Nyein, Hnin Yin Yin; Takei, Kuniharu; Javey, Ali

    2016-06-01

    Printed electronics and sensors enable new applications ranging from low-cost disposable analytical devices to large-area sensor networks. Recent progress in printed carbon nanotube electronics in terms of materials, processing, devices, and applications is discussed on page 4397 by A. Javey and co-workers. The research challenges and opportunities regarding the processing and system-level integration are also discussed for enabling of practical applications. PMID:27273439

  2. Carbon Nanotubes: Printed Carbon Nanotube Electronics and Sensor Systems (Adv. Mater. 22/2016).

    Science.gov (United States)

    Chen, Kevin; Gao, Wei; Emaminejad, Sam; Kiriya, Daisuke; Ota, Hiroki; Nyein, Hnin Yin Yin; Takei, Kuniharu; Javey, Ali

    2016-06-01

    Printed electronics and sensors enable new applications ranging from low-cost disposable analytical devices to large-area sensor networks. Recent progress in printed carbon nanotube electronics in terms of materials, processing, devices, and applications is discussed on page 4397 by A. Javey and co-workers. The research challenges and opportunities regarding the processing and system-level integration are also discussed for enabling of practical applications.

  3. Nanoscale Electrodes: Nanoscale Electrodes for Flexible Electronics by Swelling Controlled Cracking (Adv. Mater. 30/2016).

    Science.gov (United States)

    Zhao, Qiang; Wang, Wenjun; Shao, Jinyou; Li, Xiangming; Tian, Hongmiao; Liu, Lu; Mei, Xuesong; Ding, Yucheng; Lu, Bingheng

    2016-08-01

    The fabrication of nanospaced electrodes on a flexible substrate is a great challenge. W. Wang, J. Shao, and co-workers propose a novel approach to fabricate nanogap electrodes for flexible electronics using a swelling-controlled cracking method, which is described on page 6337. This method has the advantages of high applicability, parallel manufacturing capacity, and compatibility with flexible substrates. It provides a new way to create high-performance flexible electronics in a cost-efficient fashion.

  4. Light-Emitting Diodes: Phosphorescent Nanocluster Light-Emitting Diodes (Adv. Mater. 2/2016).

    Science.gov (United States)

    Kuttipillai, Padmanaban S; Zhao, Yimu; Traverse, Christopher J; Staples, Richard J; Levine, Benjamin G; Lunt, Richard R

    2016-01-13

    On page 320, R. R. Lunt and co-workers demonstrate electroluminescence from earth-abundant phosphorescent metal halide nanoclusters. These inorganic emitters, which exhibit rich photophysics combined with a high phosphorescence quantum yield, are employed in red and near-infrared light-emitting diodes, providing a new platform of phosphorescent emitters for low-cost and high-performance light-emission applications.

  5. Nanoscale Electrodes: Nanoscale Electrodes for Flexible Electronics by Swelling Controlled Cracking (Adv. Mater. 30/2016).

    Science.gov (United States)

    Zhao, Qiang; Wang, Wenjun; Shao, Jinyou; Li, Xiangming; Tian, Hongmiao; Liu, Lu; Mei, Xuesong; Ding, Yucheng; Lu, Bingheng

    2016-08-01

    The fabrication of nanospaced electrodes on a flexible substrate is a great challenge. W. Wang, J. Shao, and co-workers propose a novel approach to fabricate nanogap electrodes for flexible electronics using a swelling-controlled cracking method, which is described on page 6337. This method has the advantages of high applicability, parallel manufacturing capacity, and compatibility with flexible substrates. It provides a new way to create high-performance flexible electronics in a cost-efficient fashion. PMID:27493073

  6. Osteoanabolic Implants: Osteoanabolic Implant Materials for Orthopedic Treatment (Adv. Healthcare Mater. 14/2016).

    Science.gov (United States)

    Ding, Yun-Fei; Li, Rachel W; Nakai, Masaaki; Majumdar, Trina; Zhang, Dong-Hai; Niinomi, Mitsuo; Birbilis, Nick; Smith, Paul N; Chen, Xiao-Bo

    2016-07-01

    On page 1740, Xiao-Bo Chen and co-workers report an orthopedic implant material specifically designed for osteoporotic bone fractures. A newl strontium phosphate coating applied to a bone-mimicking low elastic titanium alloy with a comparative Young's modulus to that of natural bone results in upregulating the growth of osteoblasts and downregulating that of osteoclasts. Such a promising osteoanabolic effect reveals a suitability in particular for patients who suffer from low quality bone organism and slow fracture recovery. PMID:27436105

  7. Alternative Plasmonic Materials: Alternative Plasmonic Materials: Beyond Gold and Silver (Adv. Mater. 24/2013)

    DEFF Research Database (Denmark)

    Naik, Gururaj V.; Shalaev, Vladimir M.; Boltasseva, Alexandra

    2013-01-01

    and new functionalities with applications in sensing, imaging, data storage, novel light sources, energy conversion, quantum optics and others. The cover image depicts a negatively refracting metamaterial device built from novel materials. Image prepared with the help of Dr. Alexander V. Kildishev....

  8. Artificial Synapses: Organometal Halide Perovskite Artificial Synapses (Adv. Mater. 28/2016).

    Science.gov (United States)

    Xu, Wentao; Cho, Himchan; Kim, Young-Hoon; Kim, Young-Tae; Wolf, Christoph; Park, Chan-Gyung; Lee, Tae-Woo

    2016-07-01

    A synapse-emulating electronic device based on organometal halide perovskite thin films is described by T.-W. Lee and co-workers on page 5916. The device successfully emulates important characteristics of a biological synapse. This work extends the application of organometal halide perovskites to bioinspired electronic devices, and contributes to the development of neuromorphic electronics. PMID:27442971

  9. Graphene Films: Synthesis of Graphene Films on Copper Foils by Chemical Vapor Deposition (Adv. Mater. 29/2016).

    Science.gov (United States)

    Li, Xuesong; Colombo, Luigi; Ruoff, Rodney S

    2016-08-01

    Synthesis of graphene films on copper foils is discussed by X. Li, L. Colombo, and R. S. Ruoff on page 6247. Graphene can grow on metal substrates by chemical vapor deposition of hydrocarbons. Hydrocarbons crack on a metal surface, nucleate, grow, and finally merge to form a continuous graphene film. Copper is one of the best candidates for graphene growth due to the advantages of good control over the graphene thickness, the growth of high-quality graphene, and the ease for graphene transfer, and has been widely used for production of large-area graphene films in both academia and industry. PMID:27478085

  10. Nanocarbon Paper: Flexible, High Temperature, Planar Lighting with Large Scale Printable Nanocarbon Paper (Adv. Mater. 23/2016).

    Science.gov (United States)

    Bao, Wenzhong; Pickel, Andrea D; Zhang, Qing; Chen, Yanan; Yao, Yonggang; Wan, Jiayu; Fu, Kun Kelvin; Wang, Yibo; Dai, Jiaqi; Zhu, Hongli; Drew, Dennis; Fuhrer, Michael; Dames, Chris; Hu, Liangbing

    2016-06-01

    On page 4684, C. Dames, L. Hu and co-workers report highly efficient, broadband lighting from printed hybrid nanocarbon structures with carbon nanotubes and reduced graphene oxides. The fast response and excellent stability of the flexible lighting can find applications in a range of emerging applications where the shape and format, as well as being lightweight, are important. PMID:27281044

  11. Photonic Crystals: Two-Dimensional Programmable Manipulation of Magnetic Nanoparticles on-Chip (Adv. Mater. 15/2014)

    DEFF Research Database (Denmark)

    Sarella, Anandakumar; Torti, Andrea; Donolato, Marco;

    2014-01-01

    P. Vavassori and co-workers demonstrate on page 2384 that field-controlled displacement of magnetic domain walls in ferromagnetic nano-ring structures allows for capture and 2-dimensional remote manipulation of fluidborne magnetic nanoparticles over a chip surface.......P. Vavassori and co-workers demonstrate on page 2384 that field-controlled displacement of magnetic domain walls in ferromagnetic nano-ring structures allows for capture and 2-dimensional remote manipulation of fluidborne magnetic nanoparticles over a chip surface....

  12. Wearable Strain Sensors: Carbonized Silk Fabric for Ultrastretchable, Highly Sensitive, and Wearable Strain Sensors (Adv. Mater. 31/2016).

    Science.gov (United States)

    Wang, Chunya; Li, Xiang; Gao, Enlai; Jian, Muqiang; Xia, Kailun; Wang, Qi; Xu, Zhiping; Ren, Tianling; Zhang, Yingying

    2016-08-01

    A novel carbonized plain-weave silk-fabric-based wearable strain sensor is proposed by Y. Y. Zhang and co-workers on page 6640. The sensor can be stretched up to 500% with high sensitivity in a wide strain range and can be assembled into wearable devices for the detection of both large and subtle human activities, showing great potential in human-motion detection and robotics. PMID:27511531

  13. Carbon Nanotubes: Ultrabreathable and Protective Membranes with Sub-5 nm Carbon Nanotube Pores (Adv. Mater. 28/2016).

    Science.gov (United States)

    Bui, Ngoc; Meshot, Eric R; Kim, Sangil; Peña, José; Gibson, Phillip W; Wu, Kuang Jen; Fornasiero, Francesco

    2016-07-01

    A flexible membrane with sub-5 nm single-walled carbon nanotube (SWNT) pores is developed by F. Fornasiero and co-workers, as described on page 5871, for application as a key component of protective, yet breathable fabrics. The SWNTs are shown to enable exceptionally fast transport of water vapor under a concentration driving force. Thus, membranes having SWNTs as moisture-conductive pores feature outstanding breathability and provide a high degree of protection from biological threats by size exclusion. PMID:27442972

  14. Flexible Electronics: High Pressure Chemical Vapor Deposition of Hydrogenated Amorphous Silicon Films and Solar Cells (Adv. Mater. 28/2016).

    Science.gov (United States)

    He, Rongrui; Day, Todd D; Sparks, Justin R; Sullivan, Nichole F; Badding, John V

    2016-07-01

    On page 5939, J. V. Badding and co-workers describe the unrolling of a flexible hydrogenated amorphous silicon solar cell, deposited by high-pressure chemical vapor deposition. The high-pressure deposition process is represented by the molecules of silane infiltrating the small voids between the rolled up substrate, facilitating plasma-free deposition over a very large area. The high-pressure approach is expected to also find application for 3D nanoarchitectures. PMID:27442970

  15. 3D Printing: 3D Printing of Shape Memory Polymers for Flexible Electronic Devices (Adv. Mater. 22/2016).

    Science.gov (United States)

    Zarek, Matt; Layani, Michael; Cooperstein, Ido; Sachyani, Ela; Cohn, Daniel; Magdassi, Shlomo

    2016-06-01

    On page 4449, D. Cohn, S. Magdassi, and co-workers describe a general and facile method based on 3D printing of methacrylated macromonomers to fabricate shape-memory objects that can be used in flexible and responsive electrical circuits. Such responsive objects can be used in the fabrication of soft robotics, minimal invasive medical devices, sensors, and wearable electronics. The use of 3D printing overcomes the poor processing characteristics of thermosets and enables complex geometries that are not easily accessible by other techniques. PMID:27273436

  16. Tactile Sensors: MoS2 -Based Tactile Sensor for Electronic Skin Applications (Adv. Mater. 13/2016).

    Science.gov (United States)

    Park, Minhoon; Park, Yong Ju; Chen, Xiang; Park, Yon-Kyu; Kim, Min-Seok; Ahn, Jong-Hyun

    2016-04-01

    A tactile sensor based on a MoS2 strain gauge and a graphene electrode is integrated on a finger tip by M.-S. Kim, J.-H. Ahn, and co-workers, as described on page 2556. The MoS2 and graphene can be conformally attached onto a thumbprint thanks to their outstanding mechanical flexibility. The MoS2 -based tactile sensor, showing excellent sensing properties, is expected to provide great opportunities for electronic-skin and wearable-electronics applications. PMID:27037944

  17. Organosilica: Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic-Inorganic Hybridization into Frameworks (Adv. Mater. 17/2016).

    Science.gov (United States)

    Chen, Yu; Shi, Jianlin

    2016-05-01

    Organic-inorganic hybrid materials can combine the advantages of organic and inorganic materials, and overcome their drawbacks accordingly. On page 3235, Y. Chen and J. L. Shi review and discuss research progress on the design, synthesis, structure, and composition control of organic-inorganic hybrid mesoporous organosilica nanoparticles (MONs). Extensive applications of MONs in nanotechnology, mainly in nanomedicine, nanocatalysis and nanofabrication are discussed.

  18. Carbon Nanotubes: Ultrabreathable and Protective Membranes with Sub-5 nm Carbon Nanotube Pores (Adv. Mater. 28/2016).

    Science.gov (United States)

    Bui, Ngoc; Meshot, Eric R; Kim, Sangil; Peña, José; Gibson, Phillip W; Wu, Kuang Jen; Fornasiero, Francesco

    2016-07-01

    A flexible membrane with sub-5 nm single-walled carbon nanotube (SWNT) pores is developed by F. Fornasiero and co-workers, as described on page 5871, for application as a key component of protective, yet breathable fabrics. The SWNTs are shown to enable exceptionally fast transport of water vapor under a concentration driving force. Thus, membranes having SWNTs as moisture-conductive pores feature outstanding breathability and provide a high degree of protection from biological threats by size exclusion.

  19. Biphasic Metal Films: Intrinsically Stretchable Biphasic (Solid-Liquid) Thin Metal Films (Adv. Mater. 22/2016).

    Science.gov (United States)

    Hirsch, Arthur; Michaud, Hadrien O; Gerratt, Aaron P; de Mulatier, Séverine; Lacour, Stéphanie P

    2016-06-01

    On page 4507, S. P. Lacour and co-workers present highly conductive and stretchable solid-liquid films that are formed by physical vapor deposition of gallium onto an alloying gold layer. The image shows patterns defined by lift-off on an elastomer membrane. The magnified view is a false-color scanning electron microscopy (SEM) image (×5000) of the surface of the films under 50% applied strain, showing the liquid Ga (blue-gray) flowing between the AuGa2 /Ga clusters (gold). PMID:27273441

  20. 3D Printing: 3D Printing of Shape Memory Polymers for Flexible Electronic Devices (Adv. Mater. 22/2016).

    Science.gov (United States)

    Zarek, Matt; Layani, Michael; Cooperstein, Ido; Sachyani, Ela; Cohn, Daniel; Magdassi, Shlomo

    2016-06-01

    On page 4449, D. Cohn, S. Magdassi, and co-workers describe a general and facile method based on 3D printing of methacrylated macromonomers to fabricate shape-memory objects that can be used in flexible and responsive electrical circuits. Such responsive objects can be used in the fabrication of soft robotics, minimal invasive medical devices, sensors, and wearable electronics. The use of 3D printing overcomes the poor processing characteristics of thermosets and enables complex geometries that are not easily accessible by other techniques.

  1. Nanopillars: Large Area Fabrication of Leaning Silicon Nanopillars for Surface Enhanced Raman Spectroscopy (Adv. Mater. 10/2012)

    DEFF Research Database (Denmark)

    Schmidt, Michael Stenbæk; Hübner, Jörg; Boisen, Anja

    2012-01-01

    M. S. Schmidt et al. describe on page OP11 a simple, two-step fabrication process to as-semble flexible, freestanding nanopillars into large-area substrates. These substrates can be made using readily available silicon-processing equipment and are suitable for SERS, having a large, uniform Raman ...

  2. Ferromagnetism: Sulfur Doping Induces Strong Ferromagnetic Ordering in Graphene: Effect of Concentration and Substitution Mechanism (Adv. Mater. 25/2016).

    Science.gov (United States)

    Tuček, Jiří; Błoński, Piotr; Sofer, Zdeněk; Šimek, Petr; Petr, Martin; Pumera, Martin; Otyepka, Michal; Zbořil, Radek

    2016-07-01

    R. Zbořil and co-workers show that doping a graphene lattice with sulfur induces magnetic centers which display ferromagnetic order below ≈62 K. As described on page 5045, sulfur doping promotes magnetically active configurations resembling the gamma-thiothiapyrone motif. Enhanced magnetic properties of sulfur-doped graphene are attributed to two unpaired electrons from each sulfur atom injected into the graphene conducting band where they are delocalized between the S and C atoms. PMID:27372723

  3. Perovskite Solar Cells: High Efficiency Pb-In Binary Metal Perovskite Solar Cells (Adv. Mater. 31/2016).

    Science.gov (United States)

    Wang, Zhao-Kui; Li, Meng; Yang, Ying-Guo; Hu, Yun; Ma, Heng; Gao, Xing-Yu; Liao, Liang-Sheng

    2016-08-01

    On page 6695, X. Y. Gao, L.-S. Liao, and co-workers describe the fabrication of mixed Pb-In perovskite solar cells, using indium (III) chloride and lead (II) chloride with methylammonium iodide. A maximum power conversion efficiency as high as 17.55% is achieved owing to the high quality of the perovskites with multiple ordered crystal orientations. This work demonstrates the possibility of substituting the Pb (II) by using In (III), which opens a broad route to fabricating alloy perovskite solar cells with mitigated ecological impact. PMID:27511533

  4. Microspheres: Microfluidic Generation of Monodisperse and Photoreconfigurable Microspheres for Floral Iridescence-Inspired Structural Colorization (Adv. Mater. 26/2016).

    Science.gov (United States)

    Yeo, Seon Ju; Park, Kyung Jin; Guo, Kai; Yoo, Pil J; Lee, Seungwoo

    2016-07-01

    Flowering plants have advanced their colorization strategies to divide incoming white light into spatially sequenced vivid colors, especially by using 2D grating diffractive motifs. On page 5268, P. J. Yoo, S. Lee, and co-workers conceive a new idea for a microfluidic approach to mimic this wonderful biological strategy and its practical application to the color encoding of colloidal particles. PMID:27383025

  5. Organosilica: Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic-Inorganic Hybridization into Frameworks (Adv. Mater. 17/2016).

    Science.gov (United States)

    Chen, Yu; Shi, Jianlin

    2016-05-01

    Organic-inorganic hybrid materials can combine the advantages of organic and inorganic materials, and overcome their drawbacks accordingly. On page 3235, Y. Chen and J. L. Shi review and discuss research progress on the design, synthesis, structure, and composition control of organic-inorganic hybrid mesoporous organosilica nanoparticles (MONs). Extensive applications of MONs in nanotechnology, mainly in nanomedicine, nanocatalysis and nanofabrication are discussed. PMID:27122112

  6. FunctSNP: an R package to link SNPs to functional knowledge and dbAutoMaker: a suite of Perl scripts to build SNP databases

    Directory of Open Access Journals (Sweden)

    Watson-Haigh Nathan S

    2010-06-01

    Full Text Available Abstract Background Whole genome association studies using highly dense single nucleotide polymorphisms (SNPs are a set of methods to identify DNA markers associated with variation in a particular complex trait of interest. One of the main outcomes from these studies is a subset of statistically significant SNPs. Finding the potential biological functions of such SNPs can be an important step towards further use in human and agricultural populations (e.g., for identifying genes related to susceptibility to complex diseases or genes playing key roles in development or performance. The current challenge is that the information holding the clues to SNP functions is distributed across many different databases. Efficient bioinformatics tools are therefore needed to seamlessly integrate up-to-date functional information on SNPs. Many web services have arisen to meet the challenge but most work only within the framework of human medical research. Although we acknowledge the importance of human research, we identify there is a need for SNP annotation tools for other organisms. Description We introduce an R package called FunctSNP, which is the user interface to custom built species-specific databases. The local relational databases contain SNP data together with functional annotations extracted from online resources. FunctSNP provides a unified bioinformatics resource to link SNPs with functional knowledge (e.g., genes, pathways, ontologies. We also introduce dbAutoMaker, a suite of Perl scripts, which can be scheduled to run periodically to automatically create/update the customised SNP databases. We illustrate the use of FunctSNP with a livestock example, but the approach and software tools presented here can be applied also to human and other organisms. Conclusions Finding the potential functional significance of SNPs is important when further using the outcomes from whole genome association studies. FunctSNP is unique in that it is the only R

  7. Electronic dura mater for long-term multimodal neural interfaces

    Science.gov (United States)

    Minev, Ivan R.; Musienko, Pavel; Hirsch, Arthur; Barraud, Quentin; Wenger, Nikolaus; Moraud, Eduardo Martin; Gandar, Jérôme; Capogrosso, Marco; Milekovic, Tomislav; Asboth, Léonie; Torres, Rafael Fajardo; Vachicouras, Nicolas; Liu, Qihan; Pavlova, Natalia; Duis, Simone; Larmagnac, Alexandre; Vörös, Janos; Micera, Silvestro; Suo, Zhigang; Courtine, Grégoire; Lacour, Stéphanie P.

    2015-01-01

    The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.

  8. Dura mater is a potential source of Aβ seeds.

    Science.gov (United States)

    Kovacs, Gabor G; Lutz, Mirjam I; Ricken, Gerda; Ströbel, Thomas; Höftberger, Romana; Preusser, Matthias; Regelsberger, Günther; Hönigschnabl, Selma; Reiner, Angelika; Fischer, Peter; Budka, Herbert; Hainfellner, Johannes A

    2016-06-01

    Deposition of amyloid-β (Aβ) in the brain parenchyma and vessels is one of the hallmarks of Alzheimer disease (AD). Recent observations of Aβ deposition in iatrogenic Creutzfeldt-Jakob disease (iCJD) after dural grafting or treatment with pituitary extracts raised concerns whether Aβ is capable of transmitting disease as seen in prion diseases by the disease-associated prion protein. To address this issue, we re-sampled and re-evaluated archival material, including the grafted dura mater of two cases with iCJD (28 and 33-years-old) without mutations in the AβPP, PSEN1 and PSEN2 genes, and carrying ε3/ε3 alleles of the APOE gene. In addition, we evaluated 84 dura mater samples obtained at autopsy (mean age 84.9 ± 0.3) in the community-based VITA study for the presence of Aβ deposition. We show that the dura mater may harbor Aβ deposits (13 %) in the form of cerebral amyloid angiopathy or amorphous aggregates. In both iCJD cases, the grafted dura mater had accumulated Aβ. The morphology and distribution pattern of cerebral Aβ deposition together with the lack of tau pathology distinguishes the Aβ proteinopathy in iCJD from AD, from that seen in young individuals without cognitive decline carrying one or two APOE4 alleles, and from that related to traumatic brain injury. Our novel findings of Aβ deposits in the dura mater, including the grafted dura, and the distinct cerebral Aβ distribution in iCJD support the seeding properties of Aβ. However, in contrast to prion diseases, our study suggests that such Aβ seeding is unable to reproduce the full clinicopathological phenotype of AD. PMID:27016065

  9. The 1976 Illini: Sweet Memories of Alma Mater

    OpenAIRE

    Diya Dutt

    1996-01-01

    The purpose of this article is to explore the attitudes of graduates of the class of 1976 from the University of Illinois toward their alma mater over a period of fifteen years. The central question addressed in this article is: How do former students feel about their educational institution as time passes? Early research suggests that students' attachment to their educational institution becomes weaker with the passage of time. This panel data on alumni attitudes towards the academic environ...

  10. 3D Tissue Culturing: Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations (Adv. Healthcare Mater. 13/2016).

    Science.gov (United States)

    Hagiwara, Masaya; Kawahara, Tomohiro; Nobata, Rina

    2016-07-01

    An in vitro 3D culturing platform enabling multidirectional observations of 3D biosamples is presented by M. Hagiwara and co-workers on page 1566. 3D recognition of a sample structure can be achieved by facilitating multi-directional views using a standard microscope without a laser system. The cubic platform has the potential to promote 3D culture studies, offering easy handling and compatibility with commercial culture plates at a low price tag. PMID:27384934

  11. Organic Memory Devices: 2D Mica Crystal as Electret in Organic Field-Effect Transistors for Multistate Memory (Adv. Mater. 19/2016).

    Science.gov (United States)

    Zhang, Xiaotao; He, Yudong; Li, Rongjin; Dong, Huanli; Hu, Wenping

    2016-05-01

    R. Li, H. Dong, and co-workers describe the exfoliation of cheap and abundant minerals, such as mica, into nanometer-thick 2D crystals with atomically flat surfaces. As described on page 3755, the application of the 2D electret in organic field-effect transistors is well-suited for flexible nonvolatile memory devices. Stored information can be retrieved even after power cycling. Moreover, the devices can be used as full-function transistors with a low-resistance and a high-resistance state.

  12. Water Splitting: Strongly Coupled Nafion Molecules and Ordered Porous CdS Networks for Enhanced Visible-Light Photoelectrochemical Hydrogen Evolution (Adv. Mater. 24/2016).

    Science.gov (United States)

    Zheng, Xue-Li; Song, Ji-Peng; Ling, Tao; Hu, Zhen Peng; Yin, Peng-Fei; Davey, Kenneth; Du, Xi-Wen; Qiao, Shi-Zhang

    2016-06-01

    T. Ling, X.-W. Du, S. Z. Qiao, and co-workers report strongly coupled Nafion molecules and ordered-porous CdS networks for visible-light water splitting. The image conceptually shows how the three-dimensional ordered structure effectively harvests incoming light. As described on page 4935, the inorganic CdS skeleton is homogeneously passivated by the organic Nafion molecules to facilitate hydrogen generation. PMID:27311095

  13. Photodetectors: Broad Detection Range Rhenium Diselenide Photodetector Enhanced by (3-Aminopropyl)Triethoxysilane and Triphenylphosphine Treatment (Adv. Mater. 31/2016).

    Science.gov (United States)

    Jo, Seo-Hyeon; Park, Hyung-Youl; Kang, Dong-Ho; Shim, Jaewoo; Jeon, Jaeho; Choi, Seunghyuk; Kim, Minwoo; Park, Yongkook; Lee, Jaehyeong; Song, Young Jae; Lee, Sungjoo; Park, Jin-Hong

    2016-08-01

    The effects of triphenylphosphine (PPh3 ) and (3-amino-propyl)triethoxysilane (APTES) on a rhenium diselenide (ReSe2 ) photodetector are systematically studied by J.-H. Park and co-workers on page 6711 in comparison with a conventional MoS2 device. A very high performance ReSe2 photodetector is demonstrated, which has a broad photodetection range, high photoresponsivity (1.18 × 10(6) A W(-1) ), and fast photoswitching speed (rising/decaying time: 58/263 ms).

  14. 3D Printing: 3D Printing of Conductive Complex Structures with In Situ Generation of Silver Nanoparticles (Adv. Mater. 19/2016).

    Science.gov (United States)

    Fantino, Erika; Chiappone, Annalisa; Roppolo, Ignazio; Manfredi, Diego; Bongiovanni, Roberta; Pirri, Candido Fabrizio; Calignano, Flaviana

    2016-05-01

    On page 3712, E. Fantino, A. Chiappone, and co-workers fabricate conductive 3D hybrid structures by coupling the photo-reduction of metal precursors with 3D printing technology. The generated structures consist of metal nanoparticles embedded in a polymer matrix shaped into complex multilayered architectures. 3D conductive structures are fabricated with a digital light-processing printer incorporating silver salt into photocurable formulations. PMID:27167030

  15. Sensors: A Highly Sensitive Diketopyrrolopyrrole-Based Ambipolar Transistor for Selective Detection and Discrimination of Xylene Isomers (Adv. Mater. 21/2016).

    Science.gov (United States)

    Wang, Bin; Huynh, Tan-Phat; Wu, Weiwei; Hayek, Naseem; Do, Thu Trang; Cancilla, John C; Torrecilla, Jose S; Nahid, Masrur Morshed; Colwell, John M; Gazit, Oz M; Puniredd, Sreenivasa Reddy; McNeill, Christopher R; Sonar, Prashant; Haick, Hossam

    2016-06-01

    An ambipolar organic field-effect transistor (OFET) based on poly(diketopyrrolopyrrole-terthiophene) (PDPPHD-T3) is shown by P. Sonar, H. Haick, and co-workers on page 4012 to sensitively detect xylene isomers at low to 40 ppm level in multiple sensing features. Combined with pattern-recognition algorithms, a sole ambipolar FET sensor, rather than arrays of sensors, is able to discriminate highly similar xylene structural isomers from each other. PMID:27246920

  16. Field-Effect Transistors: Ultrathin MXene-Micropattern-Based Field-Effect Transistor for Probing Neural Activity (Adv. Mater. 17/2016).

    Science.gov (United States)

    Xu, Bingzhe; Zhu, Minshen; Zhang, Wencong; Zhen, Xu; Pei, Zengxia; Xue, Qi; Zhi, Chunyi; Shi, Peng

    2016-05-01

    A field-effect transistor (FET) based on ultrathin Ti3 C2 -MXene micropatterns is developed by C. Zhi, P. Shi, and co-workers, as described on page 3333. The FET can be utilized for label-free probing of small molecules in typical biological environments, e.g., for fast detection of action potentials in primary neurons. This device is produced with a microcontact printing technique, harnessing the unique advantages for easy fabrication. PMID:27122113

  17. Explosives: Metal-Organic Framework Templated Synthesis of Copper Azide as the Primary Explosive with Low Electrostatic Sensitivity and Excellent Initiation Ability (Adv. Mater. 28/2016).

    Science.gov (United States)

    Wang, Qianyou; Feng, Xiao; Wang, Shan; Song, Naimeng; Chen, Yifa; Tong, Wenchao; Han, Yuzhen; Yang, Li; Wang, Bo

    2016-07-01

    On page 5837, L. Yang, B. Wang, and co-workers describe a metal-organic framework (MOF) templating method to synthesize copper azide uniformly anchored in a 3D interconnected carbon matrix and evenly spaced by the electron-conductive joints. This strategy sheds light on the preparation of powerful yet safe primary explosives and fulfills the need for controllable explosive systems.

  18. 3D Printing: 3D Printing of Conductive Complex Structures with In Situ Generation of Silver Nanoparticles (Adv. Mater. 19/2016).

    Science.gov (United States)

    Fantino, Erika; Chiappone, Annalisa; Roppolo, Ignazio; Manfredi, Diego; Bongiovanni, Roberta; Pirri, Candido Fabrizio; Calignano, Flaviana

    2016-05-01

    On page 3712, E. Fantino, A. Chiappone, and co-workers fabricate conductive 3D hybrid structures by coupling the photo-reduction of metal precursors with 3D printing technology. The generated structures consist of metal nanoparticles embedded in a polymer matrix shaped into complex multilayered architectures. 3D conductive structures are fabricated with a digital light-processing printer incorporating silver salt into photocurable formulations.

  19. Dye-Sensitized Solar Cells: The Future of Using Earth-Abundant Elements in Counter Electrodes for Dye-Sensitized Solar Cells (Adv. Mater. 20/2016).

    Science.gov (United States)

    Briscoe, Joe; Dunn, Steve

    2016-05-01

    Sustainability is an important concept generating traction in the research community. To be really sustainable the full life cycle of a product needs to be carefully considered. A key aspect of this is using elements that are either readily recycled or accessible in the Earth's biosphere. Jigsawing these materials together in compounds to address our future energy needs represents a great opportunity for the current generation of researchers. On page 3802, S. Dunn and J. Briscoe summarize the performance of a selection of alternative materials to replace platinum in the counter electrodes of dye-sensitized solar cells. PMID:27197641

  20. Inside Front Cover: Manipulating the Local Light Emission in Organic Light-Emitting Diodes by using Patterned Self-Assembled Monolayers (Adv. Mater. 14/2008).

    Science.gov (United States)

    Mathijssen, Simon G J; van Hal, Paul A; van den Biggelaar, Ton J M; Smits, Edsger C P; de Boer, Bert; Kemerink, Martijn; Janssen, René A J; de Leeuw, Dago M

    2008-07-17

    The inside cover shows an optical micrograph picture of an organic light-emitting diode with patterned, micro-contact-printed self-assembled monolayers (SAMs) that modify the work function of the anode, reported by Simon Mathijssen, Dago de Leeuw, and co-workers on p. 2703. In this particular light-emitting diode a fluorinated alkanethiol has been used that increases the work function and therefore improves the injection of holes. This results in a higher light emission on the positions where the SAM has been printed, which can be observed as the red pattern. PMID:25213911

  1. pH-Sensing Hydrogel Fibers: Flexible pH-Sensing Hydrogel Fibers for Epidermal Applications (Adv. Healthcare Mater. 6/2016).

    Science.gov (United States)

    Tamayol, Ali; Akbari, Mohsen; Zilberman, Yael; Comotto, Mattia; Lesha, Emal; Serex, Ludovic; Bagherifard, Sara; Chen, Yu; Fu, Guoqing; Ameri, Shideh Kabiri; Ruan, Weitong; Miller, Eric L; Dokmeci, Mehmet R; Sonkusale, Sameer; Khademhosseini, Ali

    2016-03-01

    On page 711 S. Sonkusale, A. Khademhosseini, and co-workers present pH-responsive hydrogel fibers that can be used for long-term monitoring of epidermal wound conditions. pH-responsive dyes are loaded into mesoporous microparticles, which are then embedded into hydrogel fibers developed through microfluidic spinning. The fabricated pH-responsive microfibers are flexible and can create conformal contact with skin. Images of the pH-sensing fibers during real-time pH measurement can be captured with a smart phone camera for convenient readout on-site. PMID:27006158

  2. Osteochondral Regeneration: Tuning Cell Differentiation into a 3D Scaffold Presenting a Pore Shape Gradient for Osteochondral Regeneration (Adv. Healthcare Mater. 14/2016).

    Science.gov (United States)

    Di Luca, Andrea; Lorenzo-Moldero, Ivan; Mota, Carlos; Lepedda, Antonio; Auhl, Dietmar; Van Blitterswijk, Clemens; Moroni, Lorenzo

    2016-07-01

    A combination of human mesenchymal stem cells with additive manufacturing technology for the fabrication of scaffolds with instructive properties is presented by Lorenzo Moroni and co-workers on page 1753. This new fiber deposition pattern allows the generation of pores of different shapes within the same construct. The most rhomboidal pore geometry sustained enhances alkaline phosphatase activity and osteogenic related genes expression with respect to the other gradient zones when the gradient scaffold is cultured in a medium supporting both osteogenic and chondrogenic differentiation. This may contribute to enhance osteochondral regeneration in orthopedic treatments. PMID:27436107

  3. Photoacoustic Imaging: Semiconducting Oligomer Nanoparticles as an Activatable Photoacoustic Probe with Amplified Brightness for In Vivo Imaging of pH (Adv. Mater. 19/2016).

    Science.gov (United States)

    Miao, Qingqing; Lyu, Yan; Ding, Dan; Pu, Kanyi

    2016-05-01

    Despite the great potential of photoacoustic imaging in the life sciences, the development of smart activatable photoacoustic probes remains elusive. On page 3662, K. Pu and co-workers report a facile nanoengineering approach based on semiconducting oligomer nano-particles to develop ratiometric photoacoustic probes with amplified brightness and enhanced sensing capability for accurate photoacoustic mapping of pH in the tumors of living mice.

  4. Photovoltaics: Highly Efficient Hybrid Photovoltaics Based on Hyperbranched Three-Dimensional TiO 2 Electron Transporting Materials (Adv. Mater. 18/2015)

    KAUST Repository

    Mahmood, Khalid

    2015-05-01

    Solution-processed hybrid photovoltaics are a potentially disruptive third-generation solar cell technology. On page 2859, A. Amassian and co-workers demonstrate that an electrospun hyperbranched electron-transporting material is capable of achieving highly efficient hybrid solar cells across different platforms, including lead-halide perovskites (15.5%) and dye-sensitized solar cells (11.2%).

  5. Phosphorescent OLEDs: Sky-Blue Phosphorescent OLEDs with 34.1% External Quantum Efficiency Using a Low Refractive Index Electron Transporting Layer (Adv. Mater. 24/2016).

    Science.gov (United States)

    Shin, Hyun; Lee, Jeong-Hwan; Moon, Chang-Ki; Huh, Jin-Suk; Sim, Bomi; Kim, Jang-Joo

    2016-06-01

    J.-J. Kim and co-workers achieve highly efficient blue organic light-emitting diodes (OLEDs) using a low-refractive-index layer. As described on page 4920, an external quantum efficiency over 34% is achieved, owing to the low refractive index of the materials. A milepost and a shining entrance of the castle are the metaphor indicating the way to highly efficient blue OLEDs. On the way to the castle, the depicted chemical structures serve as the light-emitting layer. PMID:27311092

  6. Stem Cell Bioprinting: Functional 3D Neural Mini-Tissues from Printed Gel-Based Bioink and Human Neural Stem Cells (Adv. Healthcare Mater. 12/2016).

    Science.gov (United States)

    Gu, Qi; Tomaskovic-Crook, Eva; Lozano, Rodrigo; Chen, Yu; Kapsa, Robert M; Zhou, Qi; Wallace, Gordon G; Crook, Jeremy M

    2016-06-01

    On page 1429 G. G. Wallace, J. M. Crook, and co-workers report the first example of fabricating neural tissue by 3D bioprinting human neural stem cells. A novel polysaccharide based bioink preserves stem cell viability and function within the printed construct, enabling self-renewal and differentiation to neurons and supporting neuroglia. Neurons are predominantly GABAergic, establish networks, are spontaneously active, and show a bicuculline induced increased calcium response. PMID:27333401

  7. 17 CFR 279.2 - Form ADV-W, notice of withdrawal from registration as investment adviser.

    Science.gov (United States)

    2010-04-01

    ...: For Federal Register citations affecting Form ADV-W, see the List of CFR Sections Affected, which... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form ADV-W, notice of... § 279.2 Form ADV-W, notice of withdrawal from registration as investment adviser. This form shall...

  8. Treatment for infection of artificial dura mater using free fascia lata.

    Science.gov (United States)

    Nakano, Takashi; Yoshikawa, Katsuhiro; Kunieda, Takeharu; Arakawa, Yoshiki; Kikuchi, Takayuki; Yamawaki, Satoko; Naitoh, Motoko; Kawai, Katsuya; Suzuki, Shigehiko

    2014-07-01

    Synthetic artificial dura mater materials, such as expanded polytetrafluoroethylene sheets, are widely used in dura mater reconstruction in cases involving brain tumors or trauma surgery. In patients with postoperative infection related to the use of artificial dura mater, surgical debridement of the infected wound and removal of the artificial dura mater materials are necessary to control infection. In cases involving cerebrospinal fluid leakage, dura mater reconstruction must be performed immediately. Many useful techniques for performing dura mater reconstruction to treat postoperative infection have been reported; however, some have drawbacks with respect to the need for microvascular anastomosis or difficulties in obtaining watertight closure. We successfully treated 6 patients with postoperative artificial dura mater infection using free thigh fascia lata. Some surgeons believe that the use of free fascia in infected wounds is dangerous because free fascia is a non-vascularized tissue. However, performing complete debridement and covering such free fascia with well-vascularized tissue allow the fascia to become vascularized and tolerant of infection. Therefore, if the blood flow in the scalp is acceptable after a sufficient debridement, free fascia lata can be used for reconstruction in patients with postoperative infection of artificial dura mater. Furthermore, skull reconstruction can be performed safely and easily with solid-type artificial bone, sometimes combined with tissue expansion, thus resulting in good aesthetic outcomes.

  9. Research gaps and technology needs in development of PHM for passive AdvSMR components

    International Nuclear Information System (INIS)

    Advanced small modular reactors (AdvSMRs), which are based on modularization of advanced reactor concepts, may provide a longer-term alternative to traditional light-water reactors and near-term small modular reactors (SMRs), which are based on integral pressurized water reactor (iPWR) concepts. SMRs are challenged economically because of losses in economy of scale; thus, there is increased motivation to reduce the controllable operations and maintenance costs through automation technologies including prognostics health management (PHM) systems. In this regard, PHM systems have the potential to play a vital role in supporting the deployment of AdvSMRs and face several unique challenges with respect to implementation for passive AdvSMR components. This paper presents a summary of a research gaps and technical needs assessment performed for implementation of PHM for passive AdvSMR components

  10. 域名系统运行机制与对ADV-DNS的扩展%DNS MECHANISM AND EXTENDING OF ADV-DNS

    Institute of Scientific and Technical Information of China (English)

    袁兆山; 宋宇; 袁曙

    2001-01-01

    本文分析了目前DNS的解析过程,并基于ADV-DNS,提出一种扩展的ADV-DNS设计模型 .它采用单向解析查询请求,进一步减少了查询的响应延迟,减少了对信道的占用,从而大大的减轻了国际和国内信道的负载.

  11. Design and Realization of Embedded VGA Interface based on ADV7120%基于ADV7120的嵌入式VGA接口设计与实现

    Institute of Scientific and Technical Information of China (English)

    付宗宝; 刘向阳; 夏林根

    2012-01-01

    介绍了一种基于 ADV7120的嵌入式VGA接口设计与实现的方法,对扫描式TFT- LCD接口时序与VGA接口时序进行了分析对比,利用S3C2440A的LCD控制器和高性能视频D/A芯片ADV7120将扫描式TFT-LCD接口转换成VGA接口,给出了转换电路原理图和LCD控制寄存器的配置方法.实验结果表明:采用这种方法可以正确输出VGA同步信号和图像数据信号,VGA显示器图像清晰稳定,满足系统要求.%Design and realization of video graphics array (VGA) interface for embedded system based on ADV7120 is introduced. Timing of TFT-LCD interface and VGA interface are analysed and compared.LCD controller in S3C2440A and high-performanced video D/A converter ADV7120 are used to convert TFT-LCD interface to VGA interface. Converting circuit diagram and configuration method of LCD controller registers are putted forward. The experiment result indicates that VGA synchronized signal and image data signal are accurate by using this method and image on VGA display is clear and stable, meeting the system requirement.

  12. Embedded System VGA Interface Design Based on ADV7125%基于ADV7125的嵌入式系统VGA接口设计

    Institute of Scientific and Technical Information of China (English)

    郑佃好; 张红雨; 张洪斌

    2011-01-01

    A design of VGA interface of the embedded system based on ADV7125 is proposed. The LCD controller of the S3C2440 pro cessor is used to construct the VGA timing. The LCD video signals are converted to VGA signals by the ADV7125 circuits with the cor responding control signal. This design has simple circuits and low cost. Experiments show that the VGA interface is simple and reliable .%主要阐述了基于ADV7125芯片的嵌入式系统的VGA接口设计方案。利用S3C2440处理器自带的LCD控制器来构造VGA时序,然后配合相应的控制信号,通过ADV7125硬件电路把S3C2440输出的LCD信号转换为标准的VGA信号输出。实验表明,该转换接口电路简单、可靠。

  13. Cranial Reconstruction following the Removal of an Infected Synthetic Dura Mater Substitute

    Directory of Open Access Journals (Sweden)

    Nobutaka Yoshioka, MD

    2014-04-01

    Conclusions: Staged cranial reconstruction after the removal of an infected synthetic dura mater substitute using an algorithmic approach is feasible and safe, produces satisfactory cosmetic results, and is not associated with any complications.

  14. Autoimmune Oophoritis with Multiple Molecular Targets Mitigated by Transgenic Expression of Mater

    OpenAIRE

    Otsuka, Noriyuki; Tong, Zhi-Bin; Vanevski, Konstantina; Tu, Wei; Cheng, Mickie H.; Nelson, Lawrence M.

    2011-01-01

    Transgenic expression of the MATER autoantigen in antigen-presenting cells significantly mitigates autoimmune oophoritis in mice with implications for diagnosis and tolerance induction in human autoimmune primary ovarian insufficiency.

  15. Mechanical and thermal properties of bacterial-cellulose-fibre-reinforced Mater-Bi® bionanocomposite

    Directory of Open Access Journals (Sweden)

    Hamonangan Nainggolan

    2013-05-01

    Full Text Available The effects of the addition of fibres of bacterial cellulose (FBC to commercial starch of Mater-Bi® have been investigated. FBC produced by cultivating Acetobacter xylinum for 21 days in glucose-based medium were purified by sodium hydroxide 2.5 wt % and sodium hypochlorite 2.5 wt % overnight, consecutively. To obtain water-free BC nanofibres, the pellicles were freeze dried at a pressure of 130 mbar at a cooling rate of 10 °C min−1. Both Mater-Bi and FBC were blended by using a mini twin-screw extruder at 160 °C for 10 min at a rotor speed of 50 rpm. Tensile tests were performed according to ASTM D638 to measure the Young’s modulus, tensile strength and elongation at break. A field emission scanning electron microscope was used to observe the morphology at an accelerating voltage of 10 kV. The crystallinity (Tc and melting temperature (Tm were measured by DSC. Results showed a significant improvement in mechanical and thermal properties in accordance with the addition of FBC into Mater-Bi. FBC is easily incorporated in Mater-Bi matrix and produces homogeneous Mater-Bi/FBC composite. The crystallinity of the Mater-Bi/FBC composites decrease in relation to the increase in the volume fraction of FBC.

  16. Research on ADV-Hop localization algorithm in wireless sensor networks

    Science.gov (United States)

    Zhao, Shijun; Xu, Xiulan; Zhang, Zhaohui; Sun, Meiling

    2008-10-01

    Wireless sensor networks (WSN) have wide applicability to many important applications including environmental monitoring, military applications and disaster management, etc. In many applications, sensors are assumed to know their absolute locations. Some localization methods of WSN have been proposed. In these methods, nodes equipped with GPS to get precise location information, namely the anchor nodes, are employed to derive the locations of other nodes. Most of the recent work focuses on increasing the accuracy in position estimation. In this paper, aiming at the high communication cost and average positioning error of DV-hop algorithm, an advanced algorithm which is called ADV-hop algorithm is proposed. Simulations are made by the network simulator NS2. The simulation results show that ADV-hop algorithm has lower communication cost and smaller average positioning error than DV-hop algorithm, which makes ADV-hop algorithm more suitable for the node location of WSN.

  17. Local-Level Prognostics Health Management Systems Framework for Passive AdvSMR Components. Interim Report

    Energy Technology Data Exchange (ETDEWEB)

    Ramuhalli, Pradeep [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Roy, Surajit [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hirt, Evelyn H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Pardini, Allan F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Jones, Anthony M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Deibler, John E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States; Pitman, Stan G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States; Tucker, Joseph C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States; Prowant, Matthew S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States; Suter, Jonathan D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States

    2014-09-12

    This report describes research results to date in support of the integration and demonstration of diagnostics technologies for prototypical AdvSMR passive components (to establish condition indices for monitoring) with model-based prognostics methods. The focus of the PHM methodology and algorithm development in this study is at the localized scale. Multiple localized measurements of material condition (using advanced nondestructive measurement methods), along with available measurements of the stressor environment, enhance the performance of localized diagnostics and prognostics of passive AdvSMR components and systems.

  18. Healing of Deep Wound Infection without Removal of Non-Absorbable Dura Mater (Neuro-Patch®): A Case Report.

    Science.gov (United States)

    Xiong, Nan-Xiang; Tan, Daisong Albert; Fu, Peng; Huang, Yi-Zhi; Tong, Song; Yu, Hua

    2016-01-01

    We report on a female patient who received microvascular decompression due to hemifacial spasm. Neuro-Patch® was used during the operation to repair and replace damaged dura mater. Six days after the operation, the incision wound was found to be infected. Abscesses were present deep in the incision. However, because the artificial dura mater was attached so tightly to the original dura mater, the infection was not able to spread inside the skull. After 3 months of meticulous wound cleaning and drug treatment to promote the growth of granulation tissue, we were able to gradually achieve healing of the infection without having to remove the non-absorbable artificial dura mater. By describing this case and the results of a review of the pertinent literature, we discuss the possibility of recovery of an infection without removal of artificial dura mater. PMID:27649762

  19. 76 FR 36993 - Medical Devices; Neurological Devices; Clarification of Classification for Human Dura Mater...

    Science.gov (United States)

    2011-06-24

    ...). In the Federal Register of November 24, 2004 (69 FR 68612), FDA published a final rule regarding... of the final rule, human dura mater was regulated as a medical device under Sec. 882.5975. As stated... HUMAN SERVICES Food and Drug Administration 21 CFR Part 882 (formerly Docket No. 1997N-0484P)...

  20. Interaction of ionizing radiation with mater; Oddzialywanie promieniowania jonizujacego z materia

    Energy Technology Data Exchange (ETDEWEB)

    Pogocki, D. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland)

    1997-10-01

    The early radiation effects (e.g. excitation, ionization) have been described and compared for different kind of radiation interacting with mater. The mechanism of energy deposition in connection with radiation dose and their spatial distribution has been shown.The commonly used definitions and units in radiation dosimetry have been also reviewed. 4 refs, 4 figs.

  1. Claudia Quinta (Pro Caelio 34 and an altar to Magna Mater

    Directory of Open Access Journals (Sweden)

    Eleanor Winsor Leach

    2010-11-01

    Full Text Available Among the items of sculpture from the Capitoline collection now housed in the Museum of the Power Station Montemartini is a marble relief altar of the Claudian Period (E. Simon's dating dedicated to the mater deorum and the navis salvia and depicting the arrival of the goddess Cybele at Rome by ship. The dedicator is one Claudia Syntyche and the sculpture alludes to the legends attached to a much honored woman of the Claudian family whom Cicero, in his oration pro Caelio brought on stage in a cameo appearance to bolster his case against the controversial contemporary woman Clodia Metelli as one of the accusers of his client M. Caelius Rufus. This paper will consider questions raised by the iconography of the altar with reference to the development of Claudia's legend in Roman mythology and subsequently ask who was this Claudia the dedicator and why did she choose Magna Mater for her vow?

  2. Targeted Drug Delivery: Carbon-Quantum-Dots-Loaded Mesoporous Silica Nanocarriers with pH-Switchable Zwitterionic Surface and Enzyme-Responsive Pore-Cap for Targeted Imaging and Drug Delivery to Tumor (Adv. Healthcare Mater. 12/2016).

    Science.gov (United States)

    Liu, Zhongning; Chen, Xin; Zhang, Xiaojin; Gooding, John Justin; Zhou, Yongsheng

    2016-06-01

    On page 1401 X. Chen, X. Zhang, Y. Zhou, and co-workers describe the synthesis of mesoporous silica nanocarriers with pH-switchable antifouling zwitterionic surfaces and blue fluorescence that are capable of enzyme-responsive drug release. The system combines tumor treatment and tracking. It shows great potential for cancer treatment, since it exhibits prolonged circulation in the blood system with zero premature release while offering selective cellular uptake, tumor labeling, and intracellular drug release in tumor tissue. PMID:27333399

  3. Human Neuron Cultures: Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks (Adv. Healthcare Mater. 15/2016).

    Science.gov (United States)

    Burbulla, Lena F; Beaumont, Kristin G; Mrksich, Milan; Krainc, Dimitri

    2016-08-01

    Dimitri Krainc, Milan Mrksich, and co-workers demonstrate the utility of microcontact printing technology for culturing of human neurons in defined patterns over extended periods of time on page 1894. This approach facilitates studies of neuronal development, cellular trafficking, and related mechanisms that require assessment of individual neurons and neuronal networks. PMID:27511952

  4. Photothermal Therapy: Cancer Cell Internalization of Gold Nanostars Impacts Their Photothermal Efficiency In Vitro and In Vivo: Toward a Plasmonic Thermal Fingerprint in Tumoral Environment (Adv. Healthcare Mater. 9/2016).

    Science.gov (United States)

    Espinosa, Ana; Silva, Amanda K A; Sánchez-Iglesias, Ana; Grzelczak, Marek; Péchoux, Christine; Desboeufs, Karine; Liz-Marzán, Luis M; Wilhelm, Claire

    2016-05-01

    Because the ultimate target for photothermal therapy is the cancer cell, heating performances must be evaluated intracellularly. On page 1040 C. Wilhelm and team provide the first in vitro and in vivo photothermal measurements in cancer cells with gold nanostars. They demonstrate that once nanostars are internalized within endosomes, heat generation can change significantly. PMID:27166618

  5. Human Neuron Cultures: Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks (Adv. Healthcare Mater. 15/2016).

    Science.gov (United States)

    Burbulla, Lena F; Beaumont, Kristin G; Mrksich, Milan; Krainc, Dimitri

    2016-08-01

    Dimitri Krainc, Milan Mrksich, and co-workers demonstrate the utility of microcontact printing technology for culturing of human neurons in defined patterns over extended periods of time on page 1894. This approach facilitates studies of neuronal development, cellular trafficking, and related mechanisms that require assessment of individual neurons and neuronal networks.

  6. Tumefactive immunoglobulin G4-related disease involving the dura mater: A case report and literature review

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Hoon; Lee, Ji Hoon; Ko, Yong; Paik, Seoung Sam; Lee, Young Jun [Dept. of Radiology, Hanyang University Hospital, Seoul (Korea, Republic of); Park, Dong Woo [Dept. of Radiology, Hanyang University Hospital, Seoul (Korea, Republic of)

    2015-08-15

    Immunoglobulin G4 (IgG4)-related disease is a well-known disorder characterized by an inflammatory reaction with an increase in the number of IgG4-positive plasma cells associated with sclerosis. IgG4-related disease often affects the dura mater with a pattern of diffuse thickening when the central nervous system is involved. However, some nodular dural thickening requires discrimination from tumors because of obviously different treatment options. We report of a case of IgG4-related disease with tumefactive dural involvement.

  7. A systematic comparison of the anti-tumoural activity and toxicity of the three Adv-TKs.

    Directory of Open Access Journals (Sweden)

    Qinglei Gao

    Full Text Available Adenovirus 5 vectors, known respectively as, the first generation, second generation and oncolytic adenovirus, have been studied extensively in preclinical and clinical trials. However, hitherto few systemic evaluations of the efficacy and toxicity of these adenoviral vectors that have reflected the vertical history of adenovirus based cancer gene therapy strategies have been undertaken. This study has chosen Adv-TK, the well-established adjuvant treatment in cancer, and compared its efficacy and safety with those of the two newly synthesized oncolytic adenovirus vectors encoding the HSV-TK gene, namely M7 and M8. The results obtained showed that systemic administration of 1×10(8 pfu M7 had an anti-tumour efficacy similar to that of 3×10(10 pfu Adv-TK whilst M8 performed even better. Furthermore, compared to Adv-TK, M7 and M8 reduced the incidence of metastases and substantially prolonged the survival time of the mice xenografted with human orthotopic gastric carcinomas with disseminated metastasis. Even more exciting, however, were the similar toxic and immune safety results obtained from the administration of high doses of M7 or M8 in comparison with Adv-TK in immunocompetent and permissive syrian hamster. The data here exhibit a comprehensive display of the efficacy and safety of the three mutants and provide evidence for the future preclinical use of the M7 and M8 viruses.

  8. EVALUATION OF RANGE ESTIMATES FOR TOYOTA FCHV-ADV UNDER OPEN ROAD DRIVING CONDITIONS

    Energy Technology Data Exchange (ETDEWEB)

    Anton, D.; Wipke, K.; Sprik, S.

    2009-07-10

    The objective of this evaluation was to independently and objectively verify driving ranges of >400 miles announced by Toyota for its new advanced Fuel Cell Hybrid Vehicle (FCHV-adv) utilizing 70 MPa compressed hydrogen. To accomplish this, participants from both Savannah River National Laboratory (SRNL) and the National Renewable Energy Laboratory (NREL) witnessed and participated in a 2-vehicle evaluation with Toyota Motor Engineering & Manufacturing North America, Inc. (TEMA) over a typical open road route for over 11 hours in one day with all relevant data recorded. SRNL and TEMA first entered into discussions of verifying the range of the advanced Toyota Fuel Cell Hybrid Vehicle (FCHV-adv) in August 2008 resulting from reported 400+ mile range by Toyota. After extended negotiations, a CRADA agreement, SRNS CRADA No. CR-04-003, was signed on May 6, 2009. Subsequently, on June 30, 2009 SRNL and NREL participated in an all-day evaluation of the FCHV-adv with TEMA to determine the real-world driving range of this vehicle through on-road driving on an extended round-trip drive between Torrance and San Diego, California. SRNL and NREL observed the vehicles being refueled at Toyota's headquarters the day before the evaluation in Torrance, CA on June 29. At 8:00 AM on June 30, the vehicles departed Torrance north toward downtown Los Angeles, then west to the Pacific Coast Highway, and down to San Diego. After lunch the vehicles retraced their route back to Torrance. The traffic encountered was much heavier than anticipated, causing the vehicles to not return to Torrance until 9 PM. Each vehicle was driven by the same Toyota driver all day, with one SRNL/NREL observer in each vehicle the entire route. Data was logged by Toyota and analyzed by NREL. The maximum range of the FCHV-adv vehicles was calculated to be 431 miles under these driving conditions. This distance was calculated from the actual range of 331.5 miles during over 11 hours driving, plus 99.5 miles

  9. In situ estimation of erosion and deposition thresholds by Acoustic Doppler Velocimeter (ADV)

    DEFF Research Database (Denmark)

    Andersen, T.J.; Fredsøe, Jørgen; Pejrup, M.

    2007-01-01

    to characterize sediment erodibility is that measurements can be carried out for long periods, which makes it possible to examine the temporal variation of erosion threshold, erosion rate and sedimentation. The maximum bed shear stresses, which was observed during a strong storm in January 2005, was only 0.7 N m......(-2) which is three to four times lower than the highest thresholds measured by EROMES experiments On sediment with biofilms during previous studies. This shows that such strong biofilms at this site will not get eroded unless degraded or physically disrupted by some other mechanism. A prerequisite...... for the determination of any of the erodibility and sedimentation parameters is that the actual bed level changes at the measuring site are known in detail. This information is obtained automatically by the ADVs used in the present study. Accurate estimates of the bed shear stress under waves in very shallow water...

  10. Mucopolysaccharidosis: thickening of dura mater at the craniocervical junction and other CT/MRI findings

    International Nuclear Information System (INIS)

    Cranial CT and/or MRI imaging of 8 patients with mucopolysaccharidosis (MPS) was retrospectively evaluated. Two patients had MPS, IH, 1 had MPS IS, 1 had MPS IVA and 4 had MPS IV. CT and MRI showed thickening of dura mater at the cranio-cervical junction, causing narrowing of the subarachnoid space, in all the patients examined. Spinal cord compression was detected in 4 patients. Other findings were: White matter alterations, mild to severe hydrocephalus, skull dysplasia and odontoid dysplasia. White matter alterations were evident as large areas and as multiple dispersed spots of prolonged T1 and T2 value. Reduced gray/white matter contrast was demonstrated on T2-weighted MRI images. It is important to examine the cranio-cervical junction carefully for thickening of dura mater in all patients with mucopolysaccharidosis examined by CT or MRI, because of the generally progressive clinical course of MPS. In patients with symptomatic cord compression, surgical intervention should be considered. (orig.)

  11. Mucopolysaccharidosis: thickening of dura mater at the craniocervical junction and other CT/MRI findings

    Energy Technology Data Exchange (ETDEWEB)

    Taccone, A. (Dept. of Radiology, G. Gaslini Inst., Genoa (Italy)); Tortori Donati, P. (Section of Neuroradiology, Dept. of Radiology, G. Gaslini Inst., Genoa (Italy)); Marzoli, A. (Dept. of Radiology, G. Gaslini Inst., Genoa (Italy)); Dell' Acqua, A. (Dept. of Radiology, G. Gaslini Inst., Genoa (Italy)); Gatti, R. (3. Pediatric Dept., G. Gaslini Inst., Genoa (Italy)); Leone, D. (Intensive Care Unit, G. Gaslini Inst., Genoa (Italy))

    1993-09-01

    Cranial CT and/or MRI imaging of 8 patients with mucopolysaccharidosis (MPS) was retrospectively evaluated. Two patients had MPS, IH, 1 had MPS IS, 1 had MPS IVA and 4 had MPS IV. CT and MRI showed thickening of dura mater at the cranio-cervical junction, causing narrowing of the subarachnoid space, in all the patients examined. Spinal cord compression was detected in 4 patients. Other findings were: White matter alterations, mild to severe hydrocephalus, skull dysplasia and odontoid dysplasia. White matter alterations were evident as large areas and as multiple dispersed spots of prolonged T1 and T2 value. Reduced gray/white matter contrast was demonstrated on T2-weighted MRI images. It is important to examine the cranio-cervical junction carefully for thickening of dura mater in all patients with mucopolysaccharidosis examined by CT or MRI, because of the generally progressive clinical course of MPS. In patients with symptomatic cord compression, surgical intervention should be considered. (orig.)

  12. MATER - Pianeta Terra-Mare: an interactive and multidisciplinary approach to Geosphere sciences

    Science.gov (United States)

    Piangiamore, Giovanna Lucia; Fanelli, Emanuela; Furia, Stefania; Garau, Daniela; Merlino, Silvia; Musacchio, Gemma; Carla Centineo, Maria

    2016-04-01

    Recent studies demonstrate that Earth and Marine Sciences are not properly treated in scholastic programs and in textbooks are included in a superficial way. These topics are interdisciplinary and experimental (biology, ecology, oceanography and geology) and the recent advance in these fields is strictly linked to technologic improvement. School cannot keep up with the huge advances of knowledge experimented in the last 20 years, also for the lack of didactic laboratories sufficiently updated to support experimental activities. In this context, in 2014-15 three Italian Research Institutes (INGV, ISMAR-CNR and ENEA-CRAM) have decided to support the Unified School District "ISA 10"of Lerici (Liguria, Italy) - comprehensive of kindergartner, primary and middle schools - to develop the project MATER - Pianeta Terra-Mare (Planet Earth and Sea). The acronym MATER (MARe and TERra) has also a gender value, as people involved in the projects were women, mostly researchers and teachers, which have worked side by side with other women belonging to environmental and cultural associations of the territory. This heterogeneous group has a common objective: to promote the diffusion of a scientific culture and to sensitize students from 3 to 14 years towards problems occurring in marine and terrestrial environments, fostering the settlement of a sustainable attitude to the exploitation of natural resources and consciousness to natural hazards, such as earthquakes and floods, quite common in the Ligurian region. MATER has been considered as one of the best projects funded by MIUR (Italian Ministry of Education, University and Research) inside the Dissemination of Scientific and Technological Culture call for the year 2014. Natural hazards (Planet Earth) and the chemical-physical aspects and resources of the marine environment (Planet Sea) were the two modules of the project. Planet Earth developed through Piovono Idee! (Cloudy with a chance of Ideas!), an interactive exhibition on

  13. Muusikapassioon mõttepeeglis. Täna kõlab "Stabat Mater" / Anne Peäske

    Index Scriptorium Estoniae

    Peäske, Anne, 1946-

    2005-01-01

    Arvo Pärdi "Passio" ettekandest 11.sept. Rakvere Kolmainu kirikus. Elmo Lööve, Raivo Palmaru, Jaan Rääts, Toivo Tulev, Aarne Talvik, Ingmar Kurg, Olev Oja ja Eleonora Pärt Arvo Pärdi muusikast. A. Pärdi "Stabat Mater" ansambli Theatre of Voices esituses 14. sept. Rakvere Kolmainu kirikus

  14. Mater Nostra: The Anti-blasphemy Message of the Feminist Punk-Prayer

    Directory of Open Access Journals (Sweden)

    Elena Ivanovna Volkova

    2014-12-01

    Full Text Available In this essay I develop a blasphemy counter-discourse arguing that it was ecclesial and state authorities who committed blasphemies, which were condemned by Pussy Riot’s punk-prayer. Thus, the performance in this respect may be interpreted as an anti-blasphemy protest. The blasphemy list includes the collaboration of the church with the authoritarian state, known as heresy of Sergianism; Caesar and Temple idolatry, blasphemy against the Holy Spirit, Virgin Mary and Folly for Christ’s sake. The punk-prayer may be interpreted as a feminine version of the Lord’s Prayer – Mater Nostra. Several corporeal narratives in the background – women’s dress code and rape debates, Virgin Mary’s belt, and its alleged miraculous ability to help women to deliver a baby – may be seen as allegories of feminist vs. patriarchal opposition in Russian religious and political culture.

  15. Immune response to dehydrated human dura mater : evaluation in a rabbit model.

    Directory of Open Access Journals (Sweden)

    Kadioglu H

    2002-07-01

    Full Text Available Ninety white hybrid rabbits, each weighing 2.5 to 3.5 kg, were used for this experimental model. Thirty rabbits were used for control, and sixty other rabbits were investigated for the response of host to the dural graft. In all animals, a dural defect, 1 x 1 cm in size, was created on the left parietal area following craniotomy. In the control group the excised free dural piece was then sutured again to the area from which it had been excised before. The dural defect was closed with dehydrated human dura mater (DHD in the half of the rabbits in the group of study, and with autogenous fascia lata (AFL in the other half. After operation, animals in each group were then subjected to one of five different groups comprising of 3,14,30,60 and 90 days follow-up periods. At the end of follow-up periods, histological, parameters such as cellular inflammatory response, development of fibrous tissue, capsulation, and calcification were examined in specimens obtained from the animals. There was no significant difference between AFL and DHD grafts. In conclusion, it seems that DHD is suitable as an ideal dural graft, because the immune response of host to DHD was almost similar to AFL.

  16. Research Status of the Artiifcial Dura Mater%人工硬脑膜材料的研究现状

    Institute of Scientific and Technical Information of China (English)

    张宇杭; 胥光申

    2016-01-01

    在神经外科手术中,硬脑膜替代物对于维持解剖学的完整和脑组织保护是十分重要的。近年来,随着组织工程和生物材料研究技术的发展,人工硬脑膜的研究取得许多进展。本文对人工硬脑膜国内外的相关文献进行了检索和综合分析,并展望了未来人工硬脑膜研究重点和发展方向。%Dura mater substitutes are of great importance in keeping anatomies intact and protecting brain tissue in neurosurgical operations. With the continuous development of tissue engineering and biomaterials in recent years, the research progress of the artiifcial dural materials has made remarkable progress. In this paper, the related literature about dura mater both at home and abroad were searched and analyzed comprehensively. The paper also examined the prospect of the focus and development direction of dura mater in the future research.

  17. Perfluorochemical (PFC liquid enhances recombinant adenovirus vector-mediated viral interleukin-10 (AdvIL-10 expression in rodent lung

    Directory of Open Access Journals (Sweden)

    Zimmerman Jerry J

    2007-05-01

    Full Text Available Abstract Adenovirus and cationic liposome mediated transfer of Interleukin-10 (IL-10, a potent anti-inflammatory cytokine, has been shown to decrease pro-inflammatory cytokine levels and overall lung inflammation in models of lung transplantation and injury. Limitations to current approaches of IL-10 gene therapy include poor vector delivery methods and pro-inflammatory properties of human IL-10 under certain conditions. We hypothesize that using perfluorochemical (PFC liquid to deliver the highly homologous viral IL-10 (vIL-10, which is predominantly anti-inflammatory with minimal pro-inflammatory activities, can potentially be a more effective strategy to combat inflammatory lung diseases. In this study, we compare the use of PFC liquid versus aerosolized method to deliver adenovirus encoding the vIL-10 gene (AdvIL-10 in C57Bl6 mice. Detectable vIL-10 levels were measured from bronchoalveolar lavage fluid and lung homogenates at one, four, ten and thirty days after AdvIL-10. Furthermore, we determined if use of PFC liquid could allow for the use of a lower dose of AdvIL-10 by comparing the levels of detectable vIL-10 at different doses of AdvIL-10 delivered +/- PFC liquid. Results showed that PFC liquid enhanced detectable vIL-10 by up to ten fold and that PFC liquid allowed the use of ten-fold less vector. PFC liquid increased detectable vIL-10 in lung homogenates at all time points; however, the increase in detectable vIL-10 in BAL fluid peaked at four days and was no longer evident by thirty days after intratracheal instillation. In summary, this is the first report utilizing PFC liquid to enhance the delivery of a potentially therapeutic molecule, vIL-10. We believe this strategy can be used to perform future studies on the use of the predominantly anti-inflammatory vIL-10 to treat inflammatory lung diseases.

  18. Update: Creutzfeldt-Jakob disease associated with cadaveric dura mater grafts--Japan, 1978-2008.

    Science.gov (United States)

    2008-10-24

    Creutzfeldt-Jakob disease (CJD) is the most common of the human prion diseases (also known as transmissible spongiform encephalopathies), which, according to the leading hypothesis, are caused by an abnormal protein (i.e., prion) that is able to induce abnormal folding of normal cellular prion proteins. Annual worldwide incidence of these always fatal neurodegenerative diseases is estimated at 0.5-2.0 cases per million population. CJD can occur sporadically, or as a genetic disease, or can be transmitted iatrogenically. In 1996, a new human prion disease, variant CJD (vCJD), was first described in the United Kingdom. This disease was believed to have resulted from human consumption of cattle products contaminated with the prions responsible for bovine spongiform encephalopathy (BSE, commonly known as mad cow disease). That year, in part to check for possible vCJD cases, a national survey was conducted in Japan; 821 CJD cases were identified, including 43 cases associated with receipt of cadaveric dura mater grafts. A single brand of dural graft (Lyodura) produced by a German manufacturer before May 1987 was identified as the most likely vehicle of transmission in all but one case. By 2003, continued surveillance in Japan had identified a total of 97 such cases. Since then, an additional 35 cases have been identified. This report updates previous reports and summarizes the investigation of all 132 cases to date linked to dural grafts. The results suggest that, because of the long incubation period between graft receipt and symptom onset (possibly >24.8 years), continued surveillance in Japan might identify additional CJD cases associated with dural grafts. PMID:18946463

  19. Laser bonding with ICG-infused chitosan patches: preliminary experiences in suine dura mater and vocal folds

    Science.gov (United States)

    Rossi, Francesca; Matteini, Paolo; Ratto, Fulvio; Pini, Roberto; Iacoangeli, Maurizio; Giannoni, Luca; Fortuna, Damiano; Di Cicco, Emiliano; Corbara, Sylwia; Dallari, Stefano

    2014-05-01

    Laser bonding is a promising minimally invasive approach, emerging as a valid alternative to conventional suturing techniques. It shows widely demonstrated advantages in wound treatment: immediate closuring effect, minimal inflammatory response and scar formation, reduced healing time. This laser based technique can overcome the difficulties in working through narrow surgical corridors (e.g. the modern "key-hole" surgery as well as the endoscopy setting) or in thin tissues that are impossible to treat with staples and/or stitches. We recently proposed the use of chitosan matrices, stained with conventional chromophores, to be used in laser bonding of vascular tissue. In this work we propose the same procedure to perform laser bonding of vocal folds and dura mater repair. Laser bonding of vocal folds is proposed to avoid the development of adhesions (synechiae), after conventional or CO2 laser surgery. Laser bonding application in neurosurgery is proposed for the treatment of dural defects being the Cerebro Spinal Fluid leaks still a major issue. Vocal folds and dura mater were harvested from 9-months old porks and used in the experimental sessions within 4 hours after sacrifice. In vocal folds treatment, an IdocyanineGreen-infused chitosan patch was applied onto the anterior commissure, while the dura mater was previously incised and then bonded. A diode laser emitting at 810 nm, equipped with a 600 μm diameter optical fiber was used to weld the patch onto the tissue, by delivering single laser spots to induce local patch/tissue adhesion. The result is an immediate adhesion of the patch to the tissue. Standard histology was performed, in order to study the induced photothermal effect at the bonding sites. This preliminary experimental activity shows the advantages of the proposed technique in respect to standard surgery: simplification of the procedure; decreased foreign-body reaction; reduced inflammatory response; reduced operating times and better handling in

  20. Visualisation of the intact dura mater and brain surface in infant autopsies: a minimally destructive technique for the post-mortem assessment of head injury.

    Science.gov (United States)

    Cheshire, Emma C; Malcomson, Roger D G; Rutty, Guy N; James, Deryk S

    2015-03-01

    During the post-mortem examination of babies and young children, it is important to be able to visualise the brain and its coverings, particularly in cases where a head injury is likely to have occurred. In this paper, we present an improved method for removal of the calvarial bones in infant autopsies to enable viewing of the dura mater and brain. In contrast to the standard post-mortem procedure for observing and removing the brain, this novel technique is minimally disruptive, allowing the dura mater to remain undamaged. Specialised paediatric neurosurgical tools were used to remove the skull bones from 23 neonates, infants and young children during post-mortem examination. In 21 of our 23 cases, the calvarial bones were removed successfully with the dura mater remaining intact. In one case, there was a thickening of the dura mater which created a strong adherence of this membrane to the bone. In another case, the dura mater was slightly damaged due to the inexperience of the operator in using the neurosurgical tools. This method of calvarial bone removal reduces the degree of post-mortem artefact and enhances the ability to observe and photographically document autopsy findings, including the artefact-free detection of signs of injury such as epidural or subdural haematoma, and brain swelling. This technique has now become a routine practise in both of our units to remove the skull bones in infant/young children post-mortem examinations.

  1. Efficacy of Spinal Pia Mater Incision and Laminoplasty Combined with Internal Fixation for Old Spinal Cord Injury

    Institute of Scientific and Technical Information of China (English)

    Gen-long Jiao; Zhi-zhong Li; Ming Tan; Yong-qin Pan; Zhi-gang Zhou

    2012-01-01

    Objective To evaluate the clinical efficacy of incising spinal pia mater to relieve pressure and unilateral open-door laminoplasty with internal screw fixation for treatment of the dated spinal cord injury.Methods From March,2009 to July,2010,16 cases with chronic cervical cord injury underwent spinal dura mater incision and unilateral open-door laminoplasty with internal screw fixation.Nerve functions of pre- and postoperation were evaluated by Frankel classification and the Japanese Orthopaedic Asso ciation (JOA) scale.The improvement rate of JOA score at the indicated time was recorded.Results Postoperative Frankel classification rating of 16 patients improved obviously.JOA scores at the 1st month,3rd month,6th month,and 12th month after surgery were 7.9±2.3,8.5±1.6,8.9±2.1,and 12.4± 2.5,respectively,and significantly increased compared with that prior to surgery (5.5±0.6).At the end of follow-up period,JOA score was significantly higher than that of pre treatment (P<0.05).The recovery was relatively rapid during the first 3 months following the surgery,then entered a platform period.Conclusion It is effective for patients with dated spinal cord injury to undergo spinal decompression and laminoplasty.

  2. Impact of holmium fibre laser radiation (λ = 2.1 μm) on the spinal cord dura mater and adipose tissue

    Science.gov (United States)

    Filatova, S. A.; Kamynin, V. A.; Ryabova, A. V.; Loshchenov, V. B.; Zelenkov, P. V.; Zolotovskii, I. O.; Tsvetkov, V. B.; Kurkov, A. S.

    2015-08-01

    The impact of holmium fibre laser radiation on the samples of biologic tissues (dura mater of spinal cord and adipose tissue with interlayers of muscle) is studied. The experimental results are evaluated by the size of carbonisation and coagulation necrosis zones. The experiment shows that in the case of irradiation of the spinal cord dura mater samples the size of carbonisation and coagulation necrosis zones is insignificant. In the adipose tissue the carbonisation zone is also insignificant, but the region of cellular structure disturbance is large. In the muscle tissue the situation is opposite. The cw laser operation provides clinically acceptable degree of destruction in tissue samples with a minimal carbonisation zone.

  3. Work Domain Analysis of a Predecessor Sodium-cooled Reactor as Baseline for AdvSMR Operational Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Ronald Farris; David Gertman; Jacques Hugo

    2014-03-01

    This report presents the results of the Work Domain Analysis for the Experimental Breeder Reactor (EBR-II). This is part of the phase of the research designed to incorporate Cognitive Work Analysis in the development of a framework for the formalization of an Operational Concept (OpsCon) for Advanced Small Modular Reactors (AdvSMRs). For a new AdvSMR design, information obtained through Cognitive Work Analysis, combined with human performance criteria, can and should be used in during the operational phase of a plant to assess the crew performance aspects associated with identified AdvSMR operational concepts. The main objective of this phase was to develop an analytical and descriptive framework that will help systems and human factors engineers to understand the design and operational requirements of the emerging generation of small, advanced, multi-modular reactors. Using EBR-II as a predecessor to emerging sodium-cooled reactor designs required the application of a method suitable to the structured and systematic analysis of the plant to assist in identifying key features of the work associated with it and to clarify the operational and other constraints. The analysis included the identification and description of operating scenarios that were considered characteristic of this type of nuclear power plant. This is an invaluable aspect of Operational Concept development since it typically reveals aspects of future plant configurations that will have an impact on operations. These include, for example, the effect of core design, different coolants, reactor-to-power conversion unit ratios, modular plant layout, modular versus central control rooms, plant siting, and many more. Multi-modular plants in particular are expected to have a significant impact on overall OpsCon in general, and human performance in particular. To support unconventional modes of operation, the modern control room of a multi-module plant would typically require advanced HSIs that would

  4. The Effects of 910-MHz Electromagnetic Field on Rat Cranial Arachnoid and Dura Mater Collagen. The Axial Periodicity of Collagen Fibrils

    OpenAIRE

    Margaret Tzaphlidou; Evangelos Fotiou

    2004-01-01

    The axial periodicity of rat arachnoid and dura mater collagen fibrils exposed to 910 MHz for 2 h/day for 30 consecutive days was measured by means of image analysis of electron-optical data. Such measurements were compared with those from sham-exposed animals. These measurements reveal that on exposure, the intermolecular interactions during collagen fibril assembly are affected.

  5. Lack of effect of the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine on arteriovenous anastomotic shunting in the dura mater of the pig.

    OpenAIRE

    den Boer, M. O.; Somers, J. A.; Saxena, P R

    1992-01-01

    1. In anaesthetized animals, the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine, reduce carotid arteriovenous anastomotic shunting. Within the carotid vascular bed arteriovenous anastomoses are located, amongst other places in the dura mater, which is a putative site of the pain during a migraine attack. 2. In this investigation, we have localized and measured the arteriovenous shunting within the carotid vascular bed of the pig by using simultaneous intracarotid injections...

  6. Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain.

    Science.gov (United States)

    Lee, Ho-Sung; Kang, Dai-In; Yoon, Seung Zhoo; Ryu, Yeon Hee; Lee, Inhyung; Kim, Hoon-Gi; Lee, Byung-Cheon; Lee, Ki Bog

    2015-07-01

    With chromium-hematoxylin staining, we found evidence for the existence of novel age-dependent network structures in the dura mater of rat brains. Under stereomicroscopy, we noticed that chromium-hematoxylin-stained threadlike structures, which were barely observable in 1-week-old rats, were networked in specific areas of the brain, for example, the lateral lobes and the cerebella, in 4-week-old rats. In 7-week-old rats, those structures were found to have become larger and better networked. With phase contrast microscopy, we found that in 1-week-old rats, chromium-hematoxylin-stained granules were scattered in the same areas of the brain in which the network structures would later be observed in the 4- and 7-week-old rats. Such age-dependent network structures were examined by using optical and transmission electron microscopy, and the following results were obtained. The scattered granules fused into networks with increasing age. Cross-sections of the age-dependent network structures demonstrated heavily-stained basophilic substructures. Transmission electron microscopy revealed the basophilic substructures to be clusters with high electron densities consisting of nanosized particles. We report these data as evidence for the existence of age-dependent network structures in the dura mater, we discuss their putative functions of age-dependent network structures beyond the general concept of the dura mater as a supporting matrix. PMID:26330833

  7. Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain

    Directory of Open Access Journals (Sweden)

    Ho-Sung Lee

    2015-01-01

    Full Text Available With chromium-hematoxylin staining, we found evidence for the existence of novel age-dependent network structures in the dura mater of rat brains. Under stereomicroscopy, we noticed that chromium-hematoxylin-stained threadlike structures, which were barely observable in 1-week-old rats, were networked in specific areas of the brain, for example, the lateral lobes and the cerebella, in 4-week-old rats. In 7-week-old rats, those structures were found to have become larger and better networked. With phase contrast microscopy, we found that in 1-week-old rats, chromium-hematoxylin-stained granules were scattered in the same areas of the brain in which the network structures would later be observed in the 4- and 7-week-old rats. Such age-dependent network structures were examined by using optical and transmission electron microscopy, and the following results were obtained. The scattered granules fused into networks with increasing age. Cross-sections of the age-dependent network structures demonstrated heavily-stained basophilic substructures. Transmission electron microscopy revealed the basophilic substructures to be clusters with high electron densities consisting of nanosized particles. We report these data as evidence for the existence of age-dependent network structures in the dura mater, we discuss their putative functions of age-dependent network structures beyond the general concept of the dura mater as a supporting matrix.

  8. Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain

    Institute of Scientific and Technical Information of China (English)

    Ho-Sung Lee; Dai-In Kang; Seung Zhoo Yoon; Yeon Hee Ryu; Inhyung Lee; Hoon-Gi Kim; Byung-Cheon Lee; Ki Bog Lee

    2015-01-01

    With chromium-hematoxylin staining, we found evidence for the existence of novel age-depen-dent network structures in the dura mater of rat brains. Under stereomicroscopy, we noticed that chromium-hematoxylin-stained threadlike structures, which were barely observable in 1-week-old rats, were networked in specific areas of the brain, for example, the lateral lobes and the cerebella, in 4-week-old rats. In 7-week-old rats, those structures were found to have become larger and better networked. With phase contrast microscopy, we found that in 1-week-old rats, chromium-hematoxylin-stained granules were scattered in the same areas of the brain in which the network structures would later be observed in the 4- and 7-week-old rats. Such age-depen-dent network structures were examined by using optical and transmission electron microscopy, and the following results were obtained. The scattered granules fused into networks with increas-ing age. Cross-sections of the age-dependent network structures demonstrated heavily-stained basophilic substructures. Transmission electron microscopy revealed the basophilic substructures to be clusters with high electron densities consisting of nanosized particles. We report these data as evidence for the existence of age-dependent network structures in the dura mater, we discuss their putative functions of age-dependent network structures beyond the general concept of the dura mater as a supporting matrix.

  9. Follicular progesterone concentrations and messenger RNA expression of MATER and OCT-4 in immature bovine oocytes as predictors of developmental competence.

    Science.gov (United States)

    Urrego, R; Herrera-Puerta, E; Chavarria, N A; Camargo, O; Wrenzycki, C; Rodriguez-Osorio, N

    2015-04-15

    The ability of bovine embryos to develop to the blastocyst stage and to implant and generate healthy offspring depends greatly on the competence of the oocyte. Oocyte competence is attributed to its close communication with the follicular environment and to its capacity to synthesize and store substantial amounts of messenger RNA. Higher developmental competence of bovine oocytes has been associated with both the expression of a cohort of developmental genes and the concentration of sex steroids in the follicular fluid. The aim of this study was to identify differences in the expression of FST in cumulus cells and OCT-4 and MATER in oocytes and the influence of the follicular progesterone and follicular estrogen concentration on the competence of bovine oocytes retrieved 30 minutes or 4 hours after slaughter. Cumulus-oocyte complexes (COCs) were left in postmortem ovaries for 30 minutes (group I) or 4 hours (group II) at 30 °C. Aspirated oocytes were then subjected to IVM, IVF, and IVC or were evaluated for MATER and OCT-4 messenger RNA abundance by quantitative real-time polymerase chain reaction. Total RNA was isolated from pools of 100 oocytes for each experimental replicate. Progesterone and estradiol concentration in follicular fluid was evaluated by immunoassay using an IMMULITE 2000 analyzer. Three repeats of in vitro embryo production were performed with a total of 455 (group I) and 470 (group II) COCs. There were no significant differences between the cleavage rates (72 hours postinsemination [hpi]) between both groups (63.5% vs. 69.1%). However, blastocyst (168 hpi) and hatching (216 hpi) rates were higher (P < 0.05) in group II compared with those of group I (21.3% vs. 30.7% and 27.6% vs. 51.5%, respectively). Group II oocytes exhibited the highest MATER and OCT-4 abundance (P < 0.05). Follicular estradiol concentration was not different between both the groups, whereas the progesterone concentration was lower (P ≤ 0.05) in group II follicles. These

  10. Permeability of dura mater

    DEFF Research Database (Denmark)

    Tfelt-Hansen, Peer Carsten

    2011-01-01

    In the wake of cortical spreading depression (CSD) it has been suggested that noxious substances diffuse through the dura with resulting firing of epidural nerves. In my view this is unlikely because there are good reasons to suggest that there must be a dura-brain barrier. Alternatively collater...

  11. Biochemistry of the normal dura mater of the human brain determination of water, sodium, potassium, calcium, phosphorus, magnesium, copper, iron, sulfur and nitrogen contents

    Directory of Open Access Journals (Sweden)

    Horacio M. Canelas

    1969-06-01

    Full Text Available The concentrations of water, sodium, potassium, calcium, phosphorus, magnesium, copper, iron, sulfur, and nitrogen were determined in samples of apparently normal dura mater removed from 18 subjects recently dead by craniocerebral trauma. The average concentrations expressed in dry weight were: water 79.55 g/100 g ± 2.52; sodium 1.63 mequiv/100 g ±0.27; potassium 3.68 mequiv/100 g ± 0.66; calcium 119.84 mg/100 g ± 107.40; phosphorus 68.2 mg/100 g ± 34.5; magnesium 0.61 mequiv/100 g ± 0.37; copper 249.8 /xg/100 g ± 109.4; iron 0.82 mg/100 g ± 0.28; sulfur 490.7 mg/100 g ± 22.5; nitrogen 3.33 g/100 g ± 0.17.

  12. Pathogenic and clinical characteristics of hepatitis B virus (HBV) pre-existing mutations related to adefovir dipivoxil (ADV) among ADV treatment-naive patients with chronic HBV infection%阿德福韦酯相关位点预存病毒变异的病原学及临床特征分析

    Institute of Scientific and Technical Information of China (English)

    毛海芳; 胡爱荣; 蒋素文; 丁世雄; 翁彭剑; 胡耀仁; 梁晓岳

    2013-01-01

    Objective To understand the pathogenic and clinical characteristics of HBV pre-existing mutations related to ADV among ADV treatment-naive patients with chronic HBV infection. Methods The gene re-sistance mutations of HBV P region in 211 ADV treatment-naive patients were analyzed by gene sequencing, meanwhile the HBV genotypes as well as HBV serum markers and HBV DNA levels were also determined. All patients were divided into pre-existing mutation group and non-mutation group based on the above data. Results Out of 211 patients, 9 were found to have pre-existing mutations related to ADV and 4 of them had ill-formed usage of other antiviral drugs except for ADV. rtN238T mutation was found to be the dominant one (44. 44%) , and multi-sites mutation (55. 56%) and mutation co-existence with wild strain (88. 89%) were al-so popular. The constituent ratios of males and end-stage liver diseases in pre-existing mutation group were higher than those in non-mutation group (P = 0. 013, <0. 001) . The average age of patients was 45. 9± 10. 5 years in pre-existing mutation group and 35. 6±10. 2 years old in non-mutation group (t=2. 978, P = 0. 003) . There were no statistically significant differences of constituent ratio of HBeAg, HBV genotypes and HBV DNA levels between the two groups. Conclusions There may be .some cases with pre-existing muta-tions in ADV treatment-naive patients, and these pre-existing mutations may be related to ill-formed usage of antiviral drugs. Male patients and patients with longer history of HBV infection are more likely to have pre-ex-ist 年个 mutations. It is important for patients to accept normative antiviral treatment in order to prevent re-sistance and avoid salvage therapy.%目的 了解慢性乙型肝炎病毒(HBV)感染者抗病毒治疗前阿德福韦酯(ADV)相关位点预存病毒变异的发生情况以及临床特点.方法 采用基因测序的方法对211例拟行抗病毒治疗的慢性HBV感染者的血清样本进行P区病

  13. An integrated system for managing multidisciplinary oceanographic data collected in the Mediterranean Sea during the basin-scale research project EU/MAST-MATER (1996 2000)

    Science.gov (United States)

    Maillard, C.; Balopoulos, E.; Giorgetti, A.; Fichaut, M.; Iona, A.; Larour, M.; Latrouite, A.; Manca, B.; Maudire, G.; Nicolas, P.; Sanchez-Cabeza, J.-A.

    2002-06-01

    An advanced computer and communication technology was used to develop an integrated system and software tools for managing a great diversity of oceanographic data collected in the Mediterranean Sea during 1996-2000. Data were obtained during 108 sea cruises, carried out within the framework of the large-scale international research project MATER (mass transfer and ecosystem response), which was financially supported by the Marine Science and Technology (MAST) Programme of the European Union (EU). Data collection involved the active participation of various research vessels and personnel coming from 58 different laboratories of 13 countries. Data formatting as well as automatic and visual data quality controls were implemented using internationally accepted standards and procedures. Various data inventories and meta-data information, accessible through the World Wide Web (WWW), are made available to the user community. A database was developed, which, along with meta-data and other data relevant to the project information, is made available to the user community in the form of a CD-ROM. The database consists of 5861 vertical profiles and 842 time series of basic physical and biogeochemical parameters collected in the seawater column as well as biogeochemical parameters from the analysis of 70 sediment cores. Furthermore, it includes 67 cruise data files of nonstandard additional biological and atmospheric parameters.

  14. 骨髓间充质干细胞修复硬脊膜缺损的应用研究%Application of bone marrow mesenchymal stem cells to repair defects in spinal dura mater

    Institute of Scientific and Technical Information of China (English)

    夏震; 郭开今; 邓斌; 蒋允昌; 章浩杰; 冯虎

    2014-01-01

    Objective To explore the feasibility and effectiveness of bone marrow mesenchymal stem cells ( BM-SCs) in repair of defects in rabbit dura mater .Methods The bone marrow was extracted from the ilium of rabbits . Then, BMSCs were isolated and purified through by density gradient centrifugation and adherence screening method before seeded onto artificial spinal dura mater .Sixteen rabbits were randomly divided into group A and group B , with eight in each group.An epidural damage model was made by removal of the L 4 vertebral plate.Then, artificial spinal dura mater was padded into the gap in group A , while artificial spinal dura mater combined with bone marrow mesenchymal stem cells was padded into the gap in group B .The animals were sacrificed 30 days after operation and the tissue within the re-paired area was collected for gross pathological and histological observation .Cell density was also calculated .Results Large amounts of fibroblasts and collagen fibers were observed in group B .Cell density in group B was higher than that of group A (P<0.05).Conclusion Bone marrow mesenchymal stem cells can promote the restoration of the dura mater .%目的:探讨骨髓间充质干细胞( BMSC )修复兔破损硬脊膜的可行性和有效性。方法穿刺抽取日本大耳白兔髂后上棘骨髓,分离BMSC,采用贴壁筛选法对分离的BMSC进行纯化,接种于人工硬脊膜上。16只日本大耳白兔,随机分成A组、B组,每组8只,制作L4椎板切除硬脊膜破损模型, A组人工硬脊膜敷贴裂口处, B组骨髓间充质干细复合人工硬脊膜敷贴裂口处。术后30天处死动物,取修复区域的组织行大体观察和病理学观察,并对成纤维细胞密度进行分析。结果 B组成纤维细胞与胶原纤维丰富,细胞密度高于A组( P<0.05)。结论骨髓间充质干细胞可以促进硬脊膜修复。

  15. Distinctive properties of plaque-type dura mater graft-associated Creutzfeldt-Jakob disease in cell-protein misfolding cyclic amplification.

    Science.gov (United States)

    Takeuchi, Atsuko; Kobayashi, Atsushi; Parchi, Piero; Yamada, Masahito; Morita, Masanori; Uno, Shusei; Kitamoto, Tetsuyuki

    2016-05-01

    There are two distinct subtypes of dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) with methionine homozygosity at codon 129 of the PRNP gene. The majority of cases is represented by a non-plaque-type (np-dCJD) resembling sporadic CJD (sCJD)-MM1 or -MV1, while the minority by a plaque-type (p-dCJD). p-dCJD shows distinctive phenotypic features, namely numerous kuru plaques and an abnormal isoform of prion protein (PrP(Sc)) intermediate in size between types 1 and 2. Transmission studies have shown that the unusual phenotypic features of p-dCJD are linked to the V2 prion strain that is associated with sCJD subtypes VV2 or -MV2. In this study, we applied protein misfolding cyclic amplification (PMCA) using recombinant human prion protein as a substrate and demonstrated that p-dCJD prions show amplification features that are distinct from those of np-dCJD. Although no amplification of np-dCJD prions was observed with either 129 M or 129 V substrate, p-dCJD prions were drastically amplified with the 129 V substrates, despite the PRNP codon 129 incompatibility between seed and substrate. Moreover, by using a type 2 PrP(Sc)-specific antibody not recognizing PrP(Sc) in p-dCJD, we found that type 2 products are generated de novo from p-dCJD prions during PMCA with the 129 V substrates. These findings suggest that our cell-PMCA is a useful tool for easily and rapidly identifying acquired CJD associated with the transmission of the V2 CJD strain to codon 129 methionine homozygotes, based on the preference for the 129 V substrate and the type of the amplified products. PMID:26878132

  16. Microarray analysis of gene expression after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats

    Institute of Scientific and Technical Information of China (English)

    Jiang Lei; Dong Zhao; Li Fengpeng; Liu Ruozhuo; Qiu Enchao; Wang Xiaolin; Yu Shengyuan

    2014-01-01

    Background The molecular and cellular origins of migraine headache are among the most complex problems in contemporary neurology.Up to now the pathogenesis of migraine still remains unclearly defined.The objective of this study was to explore new factors that may be related to the mechanism of migraine.Methods The present study performed a comprehensive analysis of gene expression in the trigeminal nucleus caudalis induced by electrical stimulation of dura mater surrounding the superior sagittal sinus in conscious rats using microarray analysis followed by quantitative real-time reverse-transcribed polymerase chain reaction (qRT-PCR) verification.Student's two sample t-test was employed when two groups were compared.A P value <0.05 was considered to be statistically significant.Results Comparing the placebo and the electrical stimulation groups,40 genes were determined to be significantly differentially expressed.These significantly differentially expressed genes were involved in many pathways,including transporter activity,tryptophan metabolism,G protein signaling,kinase activity,actin binding,signal transducer activity,anion transport,protein folding,enzyme inhibitor activity,coenzyme metabolism,binding,ion transport,cell adhesion,metal ion transport,oxidoreductase activity,mitochondrion function,and others.Most of the genes were involved in more than 2 pathways.Of particular interest is the up-regulation of Phactr3 and Akap5 and the down-regulation of Kdr.Conclusion These findings may provide important clues for a better understanding of the molecular mechanism of migraine.

  17. High capacitance organic field-effect transistors with modified gate insulator surface

    Science.gov (United States)

    Majewski, L. A.; Schroeder, R.; Grell, M.; Glarvey, P. A.; Turner, M. L.

    2004-11-01

    In this paper, we report on flexible, high capacitance, pentacene, and regioregular poly(3-hexylthiophene) (rr-P3HT) organic field-effect transistors fabricated on metallized Mylar films. The gate insulator, Al2O3, was prepared by means of anodization. We show that covering the anodized gate insulator with an octadecyltrichlorosilane self-assembled monolayer or apoly(α-methylstyrene) capping layer has the same effect on carrier mobility as for thermally grown silicon oxide. In addition, temperature-dependent measurements of mobility were performed on transistors fabricated with and without modification of the gate dielectric. In the case of both the pentacene and the rr-P3HT transistors, the μ(T ) behavior shows that the cause of the mobility enhancement through surface modification is not a reduction in the level of energetic disorder (σ in Bässler's model), as in the case of the fully amorphous organic semiconductor poly(triarylamine) [Veres et al., Adv. Funct. Mater. 13, 199 (2003)]. It appears that the surface modification improves mobility by changing the morphology of the semiconducting films.

  18. Graphene Nano-Electrodes for DNA Sequencing: an Ab initio Perspective

    Science.gov (United States)

    Scheicher, R. H.; Prasongkit, J.; Grigoriev, A.; He, Y.; Liu, M.; Ahuja, R.

    2012-02-01

    The proposal was made that a graphene nanogap could be used to probe the transverse conductance of individual nucleotides in DNA to rapidly identify the associated base sequence. Experimentally, the characteristic drop in ionic current associated with translocation events of DNA passing through a graphene nanopore was measured. Using first-principles methods, we evaluated the performance of two graphene nano-electrodes configurations for nucleobase identification. In the first study, Nano Lett. 11, 1941 (2011), we investigated the electronic transport properties of the four nucleotides when located in a graphene nanogap by employing density functional theory and the non-equilibrium Green's function method. In particular, we determined the electrical current variation at finite bias due to changes in the nucleotides orientation. Our second study, Adv. Funct. Mater. 21, 2674 (2011), utilized molecular dynamics simulations in conjunction with electronic transport calculations to explore specifically the effect of the hydrogenated graphene edges on the translocating DNA. It is found that edge-hydrogenated graphene electrodes facilitate the temporary formation of weak H-bonds with suitable atomic sites in the nucleotides.

  19. Bibliographical review on the teaching and learning of cell structure and functing

    OpenAIRE

    María Luz Rodríguez Palmero

    1997-01-01

    Bibliographic review with the aim of determing the role played by the knowledge of the cell in learning Biology. Nineteen papers have been considered under the following criteria : subject, sample, instrument, results and relevant conclusions. It also comprises eight bibliographic reviews on the subject and conclusions of Biology concepts learning. The information which has been obtained has been presented with graphics and an epistemological V which summarizes it.

  20. Alma mater eksponeerib / Kaire Nurk

    Index Scriptorium Estoniae

    Nurk, Kaire, 1960-

    2004-01-01

    Tiit Pääsukese "Maalid" Tartu Ülikooli Y-galeriis 2.-21. III, galeriist (galerist Margus Kiis). Näitus "Põletatud savi - antiigist tänapäevani" TÜ kunstimuuseumis (Berliini Antikensammlungi antiikvaasid, 17 eesti keraamiku antiigiteemalised taiesed) kuni 30. III, kuraatorid Inge Kukk, Airi Ligi, kujundaja Silver Vahtre

  1. O problema da classificação do item “onde”: advérbio ou pronome? = The problematic classification of the term where. is it an adverb or a pronoun?

    Directory of Open Access Journals (Sweden)

    Adriana dos Santos Souza

    2010-07-01

    Full Text Available Muitos trabalhos têm sido desenvolvidos a partir do item “onde”, dada a diversidade de usos que a ele são atribuídos. Face a esse fato, deparamo-nos ainda com as discussões acerca da classe gramatical na qual, tradicionalmente, insere-se o referido termo: os advérbios. Discutem-se aqui alguns pontos importantes sobre eles, como a definição tradicional, as questões históricas que permeiam essa conceituação, os problemas associados a essa tradição, além de serem apresentadas outras definições que se pautam em estudos de caráter funcionalista. A partir desse esboço, apresentamos a literatura relacionada ao onde, descrevendo a origem, as possíveis classificações morfossintáticas (advérbio/pronome e algumas acepções a ele atribuídas por diversos pesquisadores, a partir de pesquisas comcorpora de sincronias distintas.Owing to different uses assigned to the term, where has been the object of several studies. Investigations have also been made on issues with regard to its grammatical class, the adverbs, in which traditionally the term has been inserted. Important issues are raised on the adverbs, among which the traditional definition, the historical issues that pervade its concept, the problems associated with this tradition and other definitions based on functional studies. The literature related to the term where is provided, coupled to a description of its origin, its possible morphological and syntactical classifications (adverb/pronoun and some stances attributed to it by researchers as from discussions with distinct synchronies corpora.

  2. Retraction notice to “Magnetic properties of iron-based soft magnetic composites with MgO coating obtained by sol-gel method” [J. Magn. Magn. Mater. 322 (7) (2010) 808-813

    Science.gov (United States)

    Taghvaei, A. H.; Ebrahimi, A.; Ghaffari, M.; Janghorban, K.

    2012-09-01

    This article has been retracted at the request of the Editor-in-Chief. The authors have plagiarized part of a paper that had already appeared in “Properties of Soft magnetic composite with Evaporated MgO Insulation Coating for low Iron Loss” authored by G. Uozumi et al., published in Mater. Sci. Forum 534-536 (2007) 1361-1364, http://dx.doi.org/10.4028/www.scientific.net/MSF.534-536.1361. One of the conditions of submission of a paper for publication is that authors declare explicitly that their work is original and has not appeared in a publication elsewhere. Re-use of any data should be appropriately cited. As such this article represents a severe abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

  3. Experimental Study of the Protrusion of the Dura Mater at Skull-base Defects%颅底骨缺损硬脑膜膨出的实验研究

    Institute of Scientific and Technical Information of China (English)

    宋冬雷; 丁祖荣; 周良辅; 李士其

    2001-01-01

    目的:建立颅底缺损硬脑膜膨出量评估公式,为临床颅底缺损重建提供科学实验依据。方法:通过力学蠕变挠度分析,得到预计硬脑膜膨出量的力学计算公式,设计相应的力学模拟实验和动物实验加以验证。结果:力学模拟实验及动物实验证明通过力学分析得到的公式是基本正确的。结论:我们建立的颅底骨缺损硬脑膜膨出量评估公式,可以用来预测硬脑膜及其替代物膨出量的动态变化。%Aim:To establish the biomechanical assessment formula that predicts protrusion ofthe dura mater at the cranial base bone defect, and provide scientific experimental basis for cranial base defect reconstruction. Methods: The biomeehanical formula is established by using the creep reflecton analysis and validated by the simulated test and animal expeximents. Results: The simulated test and animal experiments reveal that biomechanical formula is right. Conclusion: The biomechanical formula can be used to predict the dynamic change of protrusion of the dura mater as well as its substitutes at different sizes of cranial base bone defects.

  4. Clinical analysis of 91 cases with hepatitis B after discontinuation of different doses of ADV%不同剂量阿德福韦酯停药后肝炎91例临床分析

    Institute of Scientific and Technical Information of China (English)

    顾生旺; 赵兵; 刘欢; 蒋兆荣; 焦峰

    2013-01-01

    目的:探讨不同剂量ADV治疗CHB患者停药后肝炎复发率与停药原因。方法对635例不同剂量ADV治疗的CHB患者定期检测肝功能、HBV DNA并建立Excel随访系统,比较各组停药后肝炎发生率。结果半量组停药后肝炎发生率为14.2%,常量组停药后肝炎发生率为13.7%,1.5倍量组停药后肝炎发生率为12.5%,2倍量组停药后肝炎发生率为16.2%,联合治疗组停药后肝炎发生率为19.3%;各组累计停药肝炎91例(14.3%),停药相关肝癌2例(0.3%),重症肝炎3例(0.5%),死亡4例(0.6%)。结论停药主要原因为包括效果不满意46.1%、经济困难21.9%,抗病毒认知度不够13.1%。2倍量组与联合治疗组停药肝炎发生率均高于常量组,差异均无统计学意义(P均>0.05)。加强健康教育与医患沟通,提高疾病认知度、定期检查并不断优化治疗是防止停药肝炎及相关事件的关键。%Objective To explore the different dosages of ADV for the treatment of chronic hepatitis B (CHB) patients after drug withdrawal hepatitis incidence and reason for discontinuation. Methods Total of 635 cases of different dosages of ADV therapy in patients with CHB liver meritorious service is regular detection, HBV DNA and build Excellfollow-up system, compare each withdrawal hepatitis incidence. Results Half a set of drug withdrawal hepatitis 14.2%, constant withdrawal hepatitis was 13.7%, 1.5-2 times the amount of drug withdrawal hepatitis group 12.5%-16.2%, united group of drug withdrawal hepatitis, 19.3%; Each group accumulative total withdrawal hepatitis, 91 cases (14.3%), drug cessation related hepatocellular carcinoma 2 cases, 3 cases of severe hepatitis, 4 cases died. Conclusions Main reason for the discontinuation is effect is not satisifed with 46.1%and 21.9%economic dififculties, 13.1%antiviral awareness is not enough. The drug withdrawal hepatitis incidence of 2 times the amount group and combined

  5. Kinetic Monte Carlo simulation of the efficiency roll-off, emission color, and degradation of organic light-emitting diodes (Presentation Recording)

    Science.gov (United States)

    Coehoorn, Reinder; van Eersel, Harm; Bobbert, Peter A.; Janssen, Rene A. J.

    2015-10-01

    The performance of Organic Light Emitting Diodes (OLEDs) is determined by a complex interplay of the charge transport and excitonic processes in the active layer stack. We have developed a three-dimensional kinetic Monte Carlo (kMC) OLED simulation method which includes all these processes in an integral manner. The method employs a physically transparent mechanistic approach, and is based on measurable parameters. All processes can be followed with molecular-scale spatial resolution and with sub-nanosecond time resolution, for any layer structure and any mixture of materials. In the talk, applications to the efficiency roll-off, emission color and lifetime of white and monochrome phosphorescent OLEDs [1,2] are demonstrated, and a comparison with experimental results is given. The simulations show to which extent the triplet-polaron quenching (TPQ) and triplet-triplet-annihilation (TTA) contribute to the roll-off, and how the microscopic parameters describing these processes can be deduced properly from dedicated experiments. Degradation is treated as a result of the (accelerated) conversion of emitter molecules to non-emissive sites upon a triplet-polaron quenching (TPQ) process. The degradation rate, and hence the device lifetime, is shown to depend on the emitter concentration and on the precise type of TPQ process. Results for both single-doped and co-doped OLEDs are presented, revealing that the kMC simulations enable efficient simulation-assisted layer stack development. [1] H. van Eersel et al., Appl. Phys. Lett. 105, 143303 (2014). [2] R. Coehoorn et al., Adv. Funct. Mater. (2015), publ. online (DOI: 10.1002/adfm.201402532)

  6. Flexible nanocrystal-coated glass fibers for high-performance thermoelectric energy harvesting.

    Science.gov (United States)

    Liang, Daxin; Yang, Haoran; Finefrock, Scott W; Wu, Yue

    2012-04-11

    Recent efforts on the development of nanostructured thermoelectric materials from nanowires (Boukai, A. I.; et al. Nature 2008, 451, (7175), 168-171; Hochbaum, A. I.; et al. Nature 2008, 451, (7175), 163-167) and nanocrystals (Kim, W.; et al. Phys. Rev. Lett. 2006, 96, (4), 045901; Poudel, B.; et al. Science 2008, 320, (5876), 634-638; Scheele, M.; et al. Adv. Funct. Mater. 2009, 19, (21), 3476-3483; Wang, R. Y.; et al. Nano Lett. 2008, 8, (8), 2283-2288) show the comparable or superior performance to the bulk crystals possessing the same chemical compositions because of the dramatically reduced thermal conductivity due to phonon scattering at nanoscale surface and interface. Up to date, the majority of the thermoelectric devices made from these inorganic nanostructures are fabricated into rigid configuration. The explorations of truly flexible composite-based flexible thermoelectric devices (See, K. C.; et al. Nano Lett. 2010, 10, (11), 4664-4667) have thus far achieved much less progress, which in principle could significantly benefit the conversion of waste heat into electricity or the solid-state cooling by applying the devices to any kind of objects with any kind of shapes. Here we report an example using a scalable solution-phase deposition method to coat thermoelectric nanocrystals onto the surface of flexible glass fibers. Our investigation of the thermoelectric properties yields high performance comparable to the state of the art from the bulk crystals and proof-of-concept demonstration also suggests the potential of wrapping the thermoelectric fibers on the industrial pipes to improve the energy efficiency.

  7. Collagen-inspired self-assembling materals

    NARCIS (Netherlands)

    Skrzeszewska, P.J.

    2011-01-01

      The rapid increase of the quality of life together with the progress of medical science asks for the development of new, tuneable and controllable materials. For the same reason, materials used for biomedical applications have to be increasingly biocompatible, biodegradable and biofunctional

  8. Otrokova navezanost na mater in discipliniranje otroka:

    OpenAIRE

    Cugmas, Zlatka

    1998-01-01

    This study examined relations between attachment security, maternal discipline, and emerging internalization in 124 children attending a school entry programme, the first, the third or the fourth year at primary school. The quality of the child's attachment to the mother was determined using two estimation scales which covered the child's behaviour towards the mother in stressful situations. The study mostly supported the link between gentle, psychologically oriented discipline (opposite of p...

  9. Collagen-inspired self-assembling materals

    OpenAIRE

    Skrzeszewska, P.J.

    2011-01-01

      The rapid increase of the quality of life together with the progress of medical science asks for the development of new, tuneable and controllable materials. For the same reason, materials used for biomedical applications have to be increasingly biocompatible, biodegradable and biofunctional. Most of the available systems, however, lack one property or the other. For example, conventional animal-derived gelatin that is often used in biomedicine, is susceptible to a risk of contaminatio...

  10. Alma mater ootab tagasi / Triin Tabur

    Index Scriptorium Estoniae

    Tabur, Triin

    2011-01-01

    Tartu Ülikooli arstiteaduskonna ja sotsiaalministeeriumi koostööna käivitunud täiendusõppeprogrammist, mille eesmärgiks on arstiteaduse põhiõppe lõpetanud, ent kliinilisest tööst eemaldunud arstid raviasutustesse tagasi tuua

  11. Biochemistry of the normal dura mater of the human brain determination of water, sodium, potassium, calcium, phosphorus, magnesium, copper, iron, sulfur and nitrogen contents Estudo bioquímico da dura mater normal do cérebro humano: conteúdo de água, sódio, potássio, cálcio, fósforo, magnésio, cobre ferro, enxôfre e nitrogênio

    Directory of Open Access Journals (Sweden)

    Horacio M. Canelas

    1969-06-01

    Full Text Available The concentrations of water, sodium, potassium, calcium, phosphorus, magnesium, copper, iron, sulfur, and nitrogen were determined in samples of apparently normal dura mater removed from 18 subjects recently dead by craniocerebral trauma. The average concentrations expressed in dry weight were: water 79.55 g/100 g ± 2.52; sodium 1.63 mequiv/100 g ±0.27; potassium 3.68 mequiv/100 g ± 0.66; calcium 119.84 mg/100 g ± 107.40; phosphorus 68.2 mg/100 g ± 34.5; magnesium 0.61 mequiv/100 g ± 0.37; copper 249.8 /xg/100 g ± 109.4; iron 0.82 mg/100 g ± 0.28; sulfur 490.7 mg/100 g ± 22.5; nitrogen 3.33 g/100 g ± 0.17.Foram determinadas as concentrações de água, sódio, potássio, cálcio, fósforo, magnésio, cobre, ferro, enxôfre e nitrogênio de espécimes de dura máter aparentemente normal retirados de 18 indivíduos recentemente falecidos em conseqüência de traumatismo crânio-encefálico. As concentrações médias, expressas em peso seco, foram as seguintes: água 79,55 g/100 g ± 2,52; sódio 1,63 mequiv/100 g ± 0,27; potássio 3,68 mequiv/100 g ± 0,66; cálcio 119,84 mg/100 g ± 107,40; fósforo 68,2 mg/100 g ± 34,5; magnésio 0,61 mequiv/100 g ± 0,37; cobre 249,8 mg/100 ± 109,4; ferro 0,82 mg/100 g ± 0,28; enxôfre 490,7 mg/100 g ± 22,5; nitrogênio 3,33 g/100 g ± 0,17.

  12. "… It's Really Ultimately Very Cruel …": contrasting English intensifier collocations across EFL writing and academic spoken discourse "It's Really Ultimately Very Cruel": contrastando colocações de advérbios de intensidade em inglês entre a escrita de aprendizes de EFL e o discurso acadêmico oral de falantes nativos

    Directory of Open Access Journals (Sweden)

    Leonardo Juliano Recski

    2004-12-01

    Full Text Available This paper investigates and contrasts recurrent intensifier collocations across a corpus of EFL writing - The International Corpus of Learner English - ICLE (Granger, 1993 and The Michigan Corpus of Academic Spoken English - MICASE (Simpson et al., 2002. It seeks to show that such recurrent collocations are an important part of writers and speakers' linguistic repertoire and that they may provide a window onto their lexicon. On general grounds, the results indicate that there is a great predominance of boosters over maximizers and that a limited number of maximizers and boosters are used in recurrent combinations. The analysis further revealed that maximizers tend to intensify non-gradable words while boosters tend to intensify gradable ones and that EFL writers' overuse of intensifiers appears to be associated with colloquial style and an exaggerated tone that is often considered to be inappropriate in formal academic texts.Este artigo investiga e contrasta colocações recorrentes de advérbios de intensidade entre um corpus composto por textos produzidos em inglês como L2 - o Corpus Internacional de Inglês de Aprendizes - ICLE (Granger, 1993 e o corpus de transcrições de fala de inglês acadêmico da Universidade de Michigan - MICASE (Simpson et al., 2002. O artigo busca demonstrar que a recorrência de tais colocações constitui uma parte importante do repertório lingüístico de falantes e escritores e que, assim, pode fornecer uma amostra do léxico dessas populações. De forma geral, os resultados indicam que há uma grande predominância de amplificadores sobre maximizadores e que um número reduzido de maximizadores e amplificadores são utilizados em combinações recorrentes. Além disso, a análise revelou que maximizadores tendem a intensificar palavras não escalares enquanto amplificadores tendem a intensificar palavras escalares e que o uso excessivo de advérbios de intensidade por parte dos aprendizes de L2 parece estar

  13. Electroluminescence from charge transfer states in Donor/Acceptor solar cells

    DEFF Research Database (Denmark)

    Sherafatipour, Golenaz; Madsen, Morten

    which the maximum open-circuit voltage can be estimated, and further can be used in the modeling and optimization of the OPV devices. [1] C. Deibe, T. Strobe, and V. Dyakonov, “Role of the charge transfer state in organic donor-acceptor solar cells,” Adv. Mater., vol. 22, pp. 4097–4111, 2010. [2] K...

  14. Characterization of multifunctional structural capacitors for embedded energy storage

    Science.gov (United States)

    Lin, Yirong; Sodano, Henry A.

    2009-12-01

    Multifunctional composites are a class of materials that combine structural and other functionalities such as sensing, actuation, energy harvesting, and vibration control in order to maximize structural performance while minimizing weight and complexity. Among all the multifunctional composites developed so far, piezoelectric composites have been widely studied due to the high coupling of energy between the electrical and mechanical domains and the inherently high dielectric constant. Several piezoelectric fiber composites have been developed for sensing and actuation applications; however, none of the previously studied composites fully embed all components of an energy storage device as load bearing members of the structure. A multifunctional fiber that can be embedded in a composite material to perform sensing and actuation has been recently developed [Y. Lin and H. A. Sodano, Adv. Funct. Mater. 18, 592 (2008)], in addition to providing load bearing functionality. The design was achieved by coating a common structural fiber, silicon carbide, with a barium titanate piezoelectric shell, and poling the active material radically by employing the structural fiber as one of the electrodes. The silicon carbide core fiber also carries external mechanical loading to protect the brittle barium titanate shell from fracture. The excellent piezoelectric and dielectric properties of the barium titanate material make the active structural fiber an outstanding candidate for converting and storing ambient mechanical energy into electrical energy to power other electric devices in the system. This paper focuses on the characterization of energy storage capability of the multifunctional fiber provided by the dielectric properties of the barium titanate shell. The capacitances of the multifunctional fibers with four different aspect ratios are tested and compared with the theoretical expressions for the cylindrical capacitor, while the breakdown voltages of the multifunctional

  15. Effect of Kınesıotapıng and Knee Brace on Functıonal Performance in Recreatıonal Athletes

    OpenAIRE

    Ulusoy, Burak; İldiz, Bülent; Tunay, Volga Bayrakçı

    2014-01-01

    Objectives: Kinesiotaping is a popular taping method that is used for both therapeutic and performance enchancement purposes. Knee braces are widely used for prevention in sport injuries but their performance effectiveness is still controversial. The aim of this study was to determine whether kinesiotape or brace was more effective on functional performance. Methods: A total twenty male recreational football players (Mean±Standart Deviation (SD) age: 22.5±0.68 years, height: 175.15±3.37 cm, b...

  16. Effect of Kınesıotapıng and Knee Brace on Functıonal Performance in Recreatıonal Athletes

    Science.gov (United States)

    Ulusoy, Burak; İldiz, Bülent; Tunay, Volga Bayrakçı

    2014-01-01

    Objectives: Kinesiotaping is a popular taping method that is used for both therapeutic and performance enchancement purposes. Knee braces are widely used for prevention in sport injuries but their performance effectiveness is still controversial. The aim of this study was to determine whether kinesiotape or brace was more effective on functional performance. Methods: A total twenty male recreational football players (Mean±Standart Deviation (SD) age: 22.5±0.68 years, height: 175.15±3.37 cm, body weight: 74.52±12.41 kg), voluntarily participated in this study. Participants were tested with kinesiotape, with brace and without kinesiotape and brace. Tests were applied one day after patellar kinesiotaping (correction technique). Balance property measured with Modified Y balance Test (dynamic test), agility measured by T test, muscle strength and anaerobic power assessed by vertical jump and triple hop tests. Wilcoxon signed rank test was employed for determining the statistical significance of tests with kinesiotape, with brace and without kinesiotape and brace. Results: In analysis; There were statistically significant differences found in Triple hop test with kinesiotaping and without kinesiotaping and brace, in T test with bracing and kinesiotaping, in vertical jump with kinesiotaping and without kinesiotaping and brace (pkinesiotaping in all tests) No statistically significant difference was found in modified Y balance test all groups (p> 0.05). Conclusion: Consequently, kinesiotaping had positive effects on agility and muscle strength but had no effects on balance in football players. On the other hand, brace had no effects on functional performance tests.

  17. 小儿外科手术中行丙泊酚靶控加单次硬膜的效果探究%Effect exploration of implementation of propofol target control plus one-time dura mater in pediatric surgery

    Institute of Scientific and Technical Information of China (English)

    时文俊

    2014-01-01

    Objective To investigate the implementation effect of propofol target control plus one-time dura mater in pediatric surgery. Methods Eighty children who received surgical treatment in our hospital from September 2012 to January 2014 were selected as the study subjects and randomly and evenly divided into the study group and the control group, which received one-time epidural plus propofol target control and ketamine anesthesia respectively. The patients' blood pressure, heart rate, oxyhemoglobin saturation, physical tamper, muscle relaxation and other indicators of the two groups in different time periods were compared. Results In the control group, the blood pressure and heart rates at the beginning of surgery and at the end of surgery increased significantly compared to the blood pressure and heart rate before surgery(P < 0.05), and in the study group, the blood pressure did not change significantly, but it was lower than that of the control group in the corresponding period, with statistically significant difference(P<0.05). In the study group, the heart rates at the beginning of surgery and at the end of surgery reduced significantly compared to the heart rate before surgery(P<0.05) and reduced a lot compared to the heart rate of the control group in the corresponding period(P<0.05). The study group had less physical tamper and shorter awakening time, with statistically significant differences(P < 0.05). Conclusion In pediatric surgery, the implementation of propofol target control plus one-time dura mater does not have large influence on the children's respiratory circulation and has the features of good effect, fast awakening and safety.%目的:探究在小儿外科手术中行丙泊酚靶控加单次硬膜的效果。方法选取2012年9月~2014年1月来本院接受手术治疗的80例患儿作为研究对象,随机等分为研究组和对照组,分别为单次硬膜外加丙泊酚靶控和氯胺酮麻醉,比较不同时间段的两组患者血

  18. 妊娠中期唐氏筛查在高龄孕妇产前诊断中必要性探讨%Approach the necessary of prenatal screening about down syndrome from of advanced materal age in pregnancy trimester

    Institute of Scientific and Technical Information of China (English)

    宋桂宁; 梁梅英; 张颜秋; 张璘; 徐红; 任梅宏

    2011-01-01

    Objective Approach the meaning of prenatal screening about down syndrome in prenatal diagnosis form pregnant women of advanced maternal age. Methods Amniocentesis were performed in 899 pregantwomen of advanced materal age with the indiations of prenatal diagnosis during 17-24 gestationalweeks and fetal chromom alkarynotypeswere examined in amniotic fluid.Results 6 abnomal chromosomal karyotypes were found in146 pregnantwomen with an increased risk of DS(≥1/270)(chose alpha-fetoprotein(AFP)and free E3 (uE3)and free β-hCG) .Patients with an increased risk of DS(≥1/270).(.Trisomy 21 was 4.11%(6/146 ) .12 abnomal chromosomal karyotypes were found in 753 pregnantwomen without prenatal screening.Trisomy 21 was 0.67%(5/750 ) .Conclusion It is higher effectiness among women of advanced maternal age about prenatal screening than without prenatal screening among women of advanced maternal age in pregnancy trimester.To suggest prenatal screening among women of advanced materal age in pregnancy trimester.%目的 探讨唐氏筛查在高龄孕妇产前诊断中的意义. 方法有产前诊断指征的高龄孕妇899人,孕中期17-24周行羊膜腔穿刺,取羊水检查胎儿染色体.结果 发现染色体异常6例在146例唐氏综合症筛查阳性(即孕妇血清甲胎蛋白(AFP)和游离性雌三醇(uE3)以及游离人绒毛膜促性腺激素(β-hCG)三联指标检测,将三联指标测定值输入唐氏综合征风险计算软件,以1/270为高危切割值,≥1/270确定为唐氏综合征筛查阳性)的高龄孕妇中,发现染色体异常6例唐氏综合征发生率为4.11%(6/146),高龄孕妇中未行唐氏筛查人数750人次,染色体异常人数12人,唐氏综合征发生率0.67%(5/750). 结论对高龄孕妇行孕中期血清血液筛查胎儿唐氏综合征,其筛查效率高于孕中期未行血清血液筛查的高龄孕妇,建议对高龄孕妇行孕中期胎儿唐氏综合征产前筛查.

  19. Ilves nautis oma alma mater'i õhustikku / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2007-01-01

    President Toomas Hendrik Ilves ja Gruusia president Mihheil Saakashvili külastasid New Yorgis oma kunagist õpingutepaika Columbia ülikooli. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

  20. The Marriage of Alma Mater to Adam Smith.

    Science.gov (United States)

    Buescher, John B.

    1987-01-01

    Businesses and universities must be encouraged to act from their traditional positions of strength, based on the longest view and the broadest interests. They must examine carefully their potential sources of conflict as well as opportunities for benefit before engaging in alliances that may become complex and difficult to manage. (MSE)

  1. Alma mater sõnas, pildis ja helis / Varje Sootak

    Index Scriptorium Estoniae

    Sootak, Varje, 1946-

    2007-01-01

    Tartu Ülikooli 375. aastapäeva puhul esitleti ülikooli kohvikus albumit "Universitas Tartuensis 375" ja samanimelise dokumentaalfilmi DVD-d. Viimase stsenaristideks on Jaak Lõhmus ja Lauri Vahtre, režissöörideks Rene Vilbre ja Märten Vaher

  2. Warm dense mater: another application for pulsed power hydrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Reinovsky, Robert Emil [Los Alamos National Laboratory

    2009-01-01

    Pulsed Power Hydrodynamics (PPH) is an application of low-impedance pulsed power, and high magnetic field technology to the study of advanced hydrodynamic problems, instabilities, turbulence, and material properties. PPH can potentially be applied to the study of the properties of warm dense matter (WDM) as well. Exploration of the properties of warm dense matter such as equation of state, viscosity, conductivity is an emerging area of study focused on the behavior of matter at density near solid density (from 10% of solid density to slightly above solid density) and modest temperatures ({approx}1-10 eV). Conditions characteristic of WDM are difficult to obtain, and even more difficult to diagnose. One approach to producing WDM uses laser or particle beam heating of very small quantities of matter on timescales short compared to the subsequent hydrodynamic expansion timescales (isochoric heating) and a vigorous community of researchers are applying these techniques. Pulsed power hydrodynamic techniques, such as large convergence liner compression of a large volume, modest density, low temperature plasma to densities approaching solid density or through multiple shock compression and heating of normal density material between a massive, high density, energetic liner and a high density central 'anvil' are possible ways to reach relevant conditions. Another avenue to WDM conditions is through the explosion and subsequent expansion of a conductor (wire) against a high pressure (density) gas background (isobaric expansion) techniques. However, both techniques demand substantial energy, proper power conditioning and delivery, and an understanding of the hydrodynamic and instability processes that limit each technique. In this paper we will examine the challenges to pulsed power technology and to pulsed power systems presented by the opportunity to explore this interesting region of parameter space.

  3. Alma mater NYC : võimenda, kiirenda, kuhja / Mariliis Lilover

    Index Scriptorium Estoniae

    Lilover, Mariliis

    2014-01-01

    Mariliis Liloveri arhitektuurialastest õpingutest New Yorgis (Graduate School of Architecture, Planning and Preservation at Columbia University) ja tema arvamusest, et koolide ülesandeks on koolitada selline arhitekt, kelle eesmärk peaks olema ületada nii iseennast kui ka tellija unistusi, kavandades midagi, mida klient algul ei osanud soovida, kuid usub lõpuks, et just sellisest tulemusest ta unistaski

  4. Synthesis of Nanometer-sized Mesoporous Oxide Spheres

    Institute of Scientific and Technical Information of China (English)

    LUO; Qian

    2001-01-01

    [1]Kresge C.T., Leonowicz M. E., Roth W. J. et al. , Nature, 359, 710(1992)[2]Zhao D., Feng J., Huo Q. et al., Science. 297, 548(1998)[3]Zhao D., Huo Q., Feng J. et al. , J. Am. Chem. Soc. , 120, 6 024(1998)[4]Yang P., Zhao D., Margolese D. I. et al. , Nature, 396, 152(1998)[5]Attard G. S. , Barrlett P. N. , Coleman N. R. B. et al. , Science, 278, 838(1997)[6]Antonietti M.and Goltner C. , Angew. Chem. Int. Ed. Engl., 36, 910(1997)[7]Zhao D., Yang P., Melosh N. et al., Adv. Mater., 10, 1 380(1998)[8]Huo Q., Zhao D., Feng J. et al. , Adv. Mater., 9, 974(1997)[9].Yang H. , Coombs N. , Ozin G. A. , Nature, 386, 692(1997)[10]Lin H. P., Cheng S. , Mou C. Y. , Chem. Mater. , 10, 3 772(1998)[11]Grun M. , Klaus I. L. , Unger K. , Adv. Mater. , 9, 254(1997)[12]Huo Q. S. , Feng J. L. , Schuth F. et al. , Chem. Mater. , 9, 14(1997)[13]Qi L. M., Ma J. M., Cheng H. M. et al., Chem. Mater., 10, 1 623(1998)[14]Bagshaw S. A., Pinnavaia T. J., Angew. Chem. Int. Ed. Engl. , 35, 1 102(1996)[15]Stober W. , Fink A. , Bohn E. , J. Colloid . Interface. Sci. , 26, 62(1968)

  5. 冻干硬脑膜内骨形成蛋白-自固化磷酸钙复合移植修复骨缺损%Repairing bone defects using bone morphogenetic protein and calcium phosphate cement combined with freeze-dried dura mater

    Institute of Scientific and Technical Information of China (English)

    邹国耀; 吴恒烜

    2009-01-01

    背景:骨形成蛋白和自固化磷酸钙各自有着良好的成骨能力,冻干硬脑膜内骨形成蛋白和自固化磷酸钙复合移植存在优化成骨效能的可能性.目的:以冻干硬脑膜为膜材料,观察膜内充填材料骨形成蛋白复合自固化磷酸钙移植修复节段性骨缺损的效果.设计、时间及地点:随机分组设计,动物体内组织病理学对照观察,于2006-07/2007-07在广西医科大学动物实验室完成.对象:健康成年新西兰大白兔28只,雌雄不限,体质量1.5~2.5 kg.方法:实验兔28只,其中4只用于取硬脑膜.其余24只随机分成A,B两大组,每组12只.A组制造双侧兔桡骨中段10 mm的骨缺损.一侧骨缺损用骨形成蛋白、自固化磷酸钙、冻干硬脑膜复合移植修复,为骨形成蛋白组, 另一侧不予处理作为空白对照组.B组制造单侧兔桡骨中段10 mm的骨缺损,用骨髓、自固化磷酸钙、冻干硬脑膜复合移植修复称骨髓组.主要观察指标:于术后第1,2,4,6,8,10,12周分别行双侧桡骨X射线检查.观察骨缺损处的新骨形成及骨修复情况.并于术后第2,4,8,12周切取标本行组织学检查及成骨面积分析.结果:在术后第4,8,12周,骨形成蛋白组的成骨面积大于骨髓组(P<0.05),而在实验早期(术后2周)两组间差异无显著性意义(P>0.05);在实验的各个时期,骨形成蛋白组和骨髓组的成骨面积均明显大于空白组(P<0.01).X射线结果显示,骨形成蛋白组在10~12周出现明显骨痂塑形现象;组织学病理切片结果显示,骨形成蛋白组在12周时桡骨可见成熟骨髓,骨缺损处为成熟的板层骨连接.结论:骨形成蛋白复合自固化磷酸钙与冻干硬脑膜移植具有良好的成骨作用.%BACKGROUND: Both bone morphogenetic protein (BMP) and calcium phosphate cement (CPC) have excellent osteogenic capability, so, it is possible to optimize osteogenic efficiency by combing BMP, CPC and freeze-dried dura mater (FDDM

  6. High-pressure high-temperature synthesis and structure of α-tetragonal boron

    Directory of Open Access Journals (Sweden)

    Evgeny A Ekimov and Igor P Zibrov

    2011-01-01

    Full Text Available ERRATUMThis is an Erratum for the article 2011 Sci. Technol. Adv. Mater. 12 055009The publisher regrets that there is a typographical error on page 2 of this article. The fourth sentence of section 3 should read as follows:The lines characteristic of B–H–B (1700–2000 cm-1 and B–H (2550–2650 cm-1 bonds of decaborane were not found in the Raman spectra of the crystals (figure 3 that confirms the complete decomposition of decaborane [19, 20].

  7. Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction

    NARCIS (Netherlands)

    Nakagomi, Takayuki; Molnar, Zoltan; Nakano-Doi, Akiko; Taguchi, Akihiko; Saino, Orie; Kubo, Shuji; Clausen, Martijn; Yoshikawa, Hiroo; Nakagomi, Nami; Matsuyama, Tomohiro

    2011-01-01

    Increasing evidence shows that neural stem/ progenitor cells (NSPCs) can be activated in the nonconventional neurogenic zones such as the cortex following ischemic stroke. However, the precise origin, identity, and subtypes of the ischemia-induced NSPCs (iNSPCs), which can contribute to cortical neu

  8. Talis mater, talis filia: las malas madres en los siglos XVI y XVII

    Directory of Open Access Journals (Sweden)

    Amaia Nausia Pimoulier

    2013-12-01

    Full Text Available Este artículo presenta un tipo de violencia familiar protagonizado por madres e hijas navarras de los siglos XVI y XVII. Las acu-saciones por lenocinio o alcahuetería contra las madres que emplearon a sus propias hijas en sus tratos de mediadoras sirven para ilustrar una forma de violencia que supone, entre otras cosas, una ruptura del amor materno. La preca-ria situación de la madre y las dificultades tras el fallecimiento del esposo —la gran parte de los casos están protagonizados por madres viu-das— fue el contexto general en el que se desarrollaron los malos tratos. La historia de estas mujeres representa un mal ejercicio de la autoridad materna y una forma de violencia hacia las hijas; una violencia no siempre física, pero sí emocional y psicológica.

  9. Talis mater, talis filia: las malas madres en los siglos XVI y XVII

    OpenAIRE

    Amaia Nausia Pimoulier

    2013-01-01

    Este artículo presenta un tipo de violencia familiar protagonizado por madres e hijas navarras de los siglos XVI y XVII. Las acu- saciones por lenocinio o alcahuetería contra las madres que emplearon a sus propias hijas en sus tratos de mediadoras sirven para ilustrar una forma de violencia que supone, entre otras cosas, una ruptura del amor materno. La precaria situación de la madre y las dificultades tras el fallecimiento del esposo —la gran parte de los casos están protagonizados por m...

  10. Diatoms : an ecoregional indicator of nutrients, organic mater and micropollutants pollution

    OpenAIRE

    Rimet, Frédéric,

    2012-01-01

    Diatoms are ubiquitous microalgae of an extreme diversity. This made them good indicators of aquatic ecosystems quality and they are used since 50 years for this purpose. Since year 2000, the European Water Framework Directive requires their use to assess the ecological quality of watercourses. A typological framework has to be used in order to compare comparable rivers between each other, that is, rivers of the same bioclimatic regions, flowing on the same geological substrate at similar alt...

  11. Cross-Modal Associations between Materic Painting and Classical Spanish Music

    Directory of Open Access Journals (Sweden)

    Liliana eAlbertazzi

    2015-04-01

    Full Text Available The study analyses the existence of cross-modal associations in the general population between a series of paintings and a series of clips of classical (guitar music. Because of the complexity of the stimuli, the study differs from previous analyses conducted on the association between visual and acoustic stimuli, which predominantly analysed single tones and colours by means of psychophysical methods and forced choice responses. More recently, the relation between music and shape has been analyzed in terms of music visualization, or relatively to the role played by emotion in the association, and free response paradigms have also been accepted. In our study, in order to investigate what attributes may be responsible for the phenomenon of the association between visual and acoustic stimuli, the clip/painting association was tested in two experiments: the first used the semantic differential on a unidimensional rating scale of adjectives; the second employed a specific methodology based on subjective perceptual judgments in first person account. Because of the complexity of the stimuli, it was decided to have the maximum possible uniformity of style, composition and musical colour. The results show that multisensory features expressed by adjectives such as ‘quick’, ‘agitated’, and ‘strong’, and their antonyms ‘slow’, ‘calm’, and ‘weak’ characterized both the visual and acoustic stimuli, and that they may have had a role in the associations. The results also suggest that the main perceptual features responsible for the clip/painting associations were hue, lightness, timbre, and musical tempo. Contrary to what was expected, the musical mode usually related to feelings of happiness or to feelings of sadness and spatial orientation did not play a significant role in the association. The main result of the study consists in showing the existence of cross-modal associations between high complex stimuli.

  12. STABILITY OF ORGANIC MATER OF HAPLIC CHERNOZEM AND HAPLIC LUVISOL OF DIFFERENT ECOSYSTEMS

    Directory of Open Access Journals (Sweden)

    ERIKA TOBIAŠOVÁ

    2013-12-01

    Full Text Available In this study, the changes in soil organic matter (SOM and the possibilities of their monitoring in a shorter period of time by means of carbon parameters were followed. The experiment includes four ecosystems (forest, meadow, urban, and agro-ecosystem on Haplic Chernozem (Močenok, Horná Kráľová, Trnava and Haplic Luvisol (Ludanice, Veľké Zálužie, Lovce of different localities. The objectives of this study were assessment of the differences in the stability of soil organic matter in different ecosystems and in soil types using labile forms of carbon and nitrogen, and also with dependence on particle size distribution. The highest contents of total organic carbon (TOC and labile carbon (CL were in a forest ecosystem, but in case of other ecosystems, the differences were determined only in the contents of CL. After forest ecosystem, the highest content of CL was in agro-ecosystem > meadow ecosystem > urban ecosystem. Based on parameter of lability of carbon (LC, the most labile carbon can be evaluated also in the forest ecosystem (0.209 > agro-ecosystem (0.178 > meadow ecosystem (0.119 and urban ecosystem (0.116. In the case of nitrogen, the differences were observed between the soils. Higher contents of NT and NL were recorded in Haplic Chernozen than in Haplic Luvisol. Contents of TOC (P < 0.05; r = -0.480, CNL (P < 0.05; r = -0.480, and NL (P < 0.01; r = -0.545 were in a negative correlation with the content of sand fraction. The values of studied parameters in meadow and urban ecosystems were relatively balanced, because in both cases, the vegetation cover were grass, pointing to a significant influence of vegetation on the parameters of SOM.

  13. Cross-modal associations between materic painting and classical Spanish music

    Science.gov (United States)

    Albertazzi, Liliana; Canal, Luisa; Micciolo, Rocco

    2015-01-01

    The study analyses the existence of cross-modal associations in the general population between a series of paintings and a series of clips of classical (guitar) music. Because of the complexity of the stimuli, the study differs from previous analyses conducted on the association between visual and auditory stimuli, which predominantly analyzed single tones and colors by means of psychophysical methods and forced choice responses. More recently, the relation between music and shape has been analyzed in terms of music visualization, or relatively to the role played by emotion in the association, and free response paradigms have also been accepted. In our study, in order to investigate what attributes may be responsible for the phenomenon of the association between visual and auditory stimuli, the clip/painting association was tested in two experiments: the first used the semantic differential on a unidimensional rating scale of adjectives; the second employed a specific methodology based on subjective perceptual judgments in first person account. Because of the complexity of the stimuli, it was decided to have the maximum possible uniformity of style, composition and musical color. The results show that multisensory features expressed by adjectives such as “quick,” “agitated,” and “strong,” and their antonyms “slow,” “calm,” and “weak” characterized both the visual and auditory stimuli, and that they may have had a role in the associations. The results also suggest that the main perceptual features responsible for the clip/painting associations were hue, lightness, timbre, and musical tempo. Contrary to what was expected, the musical mode usually related to feelings of happiness (major mode), or to feelings of sadness (minor mode), and spatial orientation (vertical and horizontal) did not play a significant role in the association. The consistency of the associations was shown when evaluated on the whole sample, and after considering the different backgrounds and expertise of the subjects. No substantial difference was found between expert and non-expert subjects. The methods used in the experiment (semantic differential and subjective judgements in first person account) corroborated the interpretation of the results as associations due to patterns of qualitative similarity present in stimuli of different sensory modalities and experienced as such by the subjects. The main result of the study consists in showing the existence of cross-modal associations between highly complex stimuli; furthermore, the second experiment employed a specific methodology based on subjective perceptual judgments. PMID:25954217

  14. Cross-modal associations between materic painting and classical Spanish music.

    Science.gov (United States)

    Albertazzi, Liliana; Canal, Luisa; Micciolo, Rocco

    2015-01-01

    The study analyses the existence of cross-modal associations in the general population between a series of paintings and a series of clips of classical (guitar) music. Because of the complexity of the stimuli, the study differs from previous analyses conducted on the association between visual and auditory stimuli, which predominantly analyzed single tones and colors by means of psychophysical methods and forced choice responses. More recently, the relation between music and shape has been analyzed in terms of music visualization, or relatively to the role played by emotion in the association, and free response paradigms have also been accepted. In our study, in order to investigate what attributes may be responsible for the phenomenon of the association between visual and auditory stimuli, the clip/painting association was tested in two experiments: the first used the semantic differential on a unidimensional rating scale of adjectives; the second employed a specific methodology based on subjective perceptual judgments in first person account. Because of the complexity of the stimuli, it was decided to have the maximum possible uniformity of style, composition and musical color. The results show that multisensory features expressed by adjectives such as "quick," "agitated," and "strong," and their antonyms "slow," "calm," and "weak" characterized both the visual and auditory stimuli, and that they may have had a role in the associations. The results also suggest that the main perceptual features responsible for the clip/painting associations were hue, lightness, timbre, and musical tempo. Contrary to what was expected, the musical mode usually related to feelings of happiness (major mode), or to feelings of sadness (minor mode), and spatial orientation (vertical and horizontal) did not play a significant role in the association. The consistency of the associations was shown when evaluated on the whole sample, and after considering the different backgrounds and expertise of the subjects. No substantial difference was found between expert and non-expert subjects. The methods used in the experiment (semantic differential and subjective judgements in first person account) corroborated the interpretation of the results as associations due to patterns of qualitative similarity present in stimuli of different sensory modalities and experienced as such by the subjects. The main result of the study consists in showing the existence of cross-modal associations between highly complex stimuli; furthermore, the second experiment employed a specific methodology based on subjective perceptual judgments. PMID:25954217

  15. Comparison of Dry Mater Content of Pig Faeces in Two Belt Separation Systems

    OpenAIRE

    Alonso Peralta, Francisco; Vázquez Minguela, Jesús; Sanchez Espinosa, Elvira; Ovejero Rubio, Ismael; Mateos San Juan, Aranzazu; Garcimartin Molina, Miguel Angel

    2008-01-01

    The average production of slurry per animal per day lies between 3 and 7 kg during a period of swine fattening. Spain is the world’s fourth largest producer of pork. The size of farms and their density are growing faster and faster. Therefore, slurry management is becoming an environmental problem due to air and soil pollution. Separating faeces and urine improves waste management and reduces the levels of environmental pollution. Since 1999 different systems aimed at this separation have bee...

  16. Mater Nostra: The Anti-blasphemy Message of the Feminist Punk-Prayer

    OpenAIRE

    Elena Ivanovna Volkova

    2014-01-01

    In this essay I develop a blasphemy counter-discourse arguing that it was ecclesial and state authorities who committed blasphemies, which were condemned by Pussy Riot’s punk-prayer. Thus, the performance in this respect may be interpreted as an anti-blasphemy protest. The blasphemy list includes the collaboration of the church with the authoritarian state, known as heresy of Sergianism; Caesar and Temple idolatry, blasphemy against the Holy Spirit, Virgin Mary and Folly for Christ’s sake. Th...

  17. Non-singular modified gravity: the unification of the inflation, dark energy and dark mater

    CERN Document Server

    Nojiri, Shin'ichi

    2009-01-01

    Using the fluid representation, we formulate the conditions for the appearance of all four types finite-time future singularity in modified gravity in accelerating FRW universe. It stressed that number of standard uintessence/phantom DE theories (including scalar, fluid, DBI ones, etc) brings the accelerating cosmology to future singularity precisely in the same way as singular modified gravity DE. The viable non-singular modified gravity unifying the early-time inflation with late-time acceleration is considered. It is shown that adding such non-singular theory to another realistic singular modified gravity which has the accelerating solution with future singularity may cure the singularity of resulting combined model. This universal scenario may be naturally applied to standard singular DE models as well as to inflationary theories with initial singularity. This suggests the additional fundamental reasoning for modification of General Relativity.

  18. Graphene sheets stacked polyacrylate latex composites for ultra-efficient electromagnetic shielding

    Science.gov (United States)

    Li, Yong; Zhang, Song; Ni, Yuwei

    2016-07-01

    Graphene sheets (GS) are at the forefront of electromagnetic interference (EMI) shielding/attenuation materials science research because of their excellent electrical properties (Wen B et al 2014 Adv. Mater. 26 3484, Zhang Y et al 2015 Adv. Mater. 27 2049). GS/polyacrylate (PA) composites were prepared using a solvent-free latex technology, which favored the build-up of a segregated GS architecture stacked in the polymer matrix. GS were obtained from graphite flakes (GF) via a mechanical delamination approach in water. The microstructure, electrical, dielectric and electromagnetic shielding properties of the GS/PA composites were correlated in this manuscript. A remarkably low percolation threshold of ∼0.11 mass per cent for room-temperature electrical conductivity was obtained in the GS/PA composites owing to the stacked architecture of GS with high aspect ratios. This unique nanostructured GS architecture not only enhanced the electrical conductivity of composites, but also dramatically increased complex permittivity by inducing strong Maxwell–Wagner–Sillars (MWS) polarization at the highly conductive GS/non-conductive PA interfaces. The EMI shielding effectiveness (SE) of these composites was enhanced with increasing GS content, and the composite with 6 wt% GS loading exhibited a high EMI SE of ∼66 dB over a frequency of 8.2–12.4 GHz, resulting from the pronounced conduction loss, dielectric relaxation, and multi-scattering.

  19. A dor durante a punção do canal vertebral e sua relação com a inervação do ligamento amarelo, da dura-máter e do ligamento longitudinal posterior El dolor durante la punción del canal vertebral y su relación con la inervación del ligamento amarillo, de la dura-máter y del ligamento longitudinal posterior Pain during spinal canal puncture and its relationship with ligamentum flavum, dura-mater and posterior longitudinal ligament innervation

    Directory of Open Access Journals (Sweden)

    Edmundo Zarzur

    2004-12-01

    influence of general anesthesia and that is why blockade with conscious patients is advisable. Pain is only referred when needle or catheter tip bypass the medium sagital plane to reach the antero-lateral epidural compartment, thus being able to touch nervous rootlets close to intervertebral foramina. Except for studies on skin, subcutaneous tissue and interspinous ligament innervation, this study aimed at reviewing the innervation of some spinal canal structures, namely, ligamentum flavum, posterior longitudinal ligament, dura-mater and intervertebral disk. CONTENTS: Studies on spinal canal innervation are presented in this literature review, aiming at understanding pain during spinal puncture. CONCLUSIONS: Ligamentum flavum is not innervated, thus explaining lack of pain during puncture. Other pains during puncture may be attributed to Luschka's nerve, which innervates posterior longitudinal ligament and dural ventral portion.

  20. Os advérbios já, mais e ainda nas orações negativas

    Directory of Open Access Journals (Sweden)

    Maria Angélica Furtado Cunha

    2012-02-01

    Full Text Available This paper follows a functional approach which takes into account the real use of language as an instrument of communication. We are malnly lnterested ln lnvestigating the ways through whlch syntax, semantics and pragmatics interact. ln order to do this, we study the behaviour of the adverbs já, mais and ainda ln negative sentences. First, we review the use of some elements which reinforce the very idea of negation. Secondly, we deal, specifically, with the adverbs, já, mais and ainda as a reinforcement to the negative. Thirdly, we aim at verifying their behaviour from an argumentative perspective. Finally, we present our conclusions.

  1. Adv. Simulation for Additive Manufacturing: 11/2014 Wkshp. Report for U.S. DOE/EERE/AMO

    Energy Technology Data Exchange (ETDEWEB)

    Turner, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Babu, Sudarsanam Suresh [Univ. of Tennessee, Knoxville, TN (United States); Blue, Craig A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-07-01

    The overarching question for the workshop was as following: How do we best utilize advanced modeling and high-performance computing (HPC) to address key challenges and opportunities in order to realize the full potential of additive manufacturing; and what are the key challenges of additive manufacturing to which modeling and simulation can contribute solutions, and what will it take to meet these challenges?

  2. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    International Nuclear Information System (INIS)

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d’Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet the extra-European connections with Brazil, China and India will be guaranteed: in China, with the Shanghai Observatory of the Chinese Academy of Science, studying the formation and evolution of large-scale structure and galaxies; in India, with the Indian Centre for Space Physics (ICSP), renowned for its research on compact objects as well as on solar physics and astrochemistry; in Brazil with ICRANet Brazil where a successful program of research and teaching in relativistic astrophysics has been established in recent years

  3. Efeito da quercetina sobre o extravasamento plasmático no sistema nervoso dura-mater de ratos

    Directory of Open Access Journals (Sweden)

    Luiz Arthur Rangel Cyrino

    2002-01-01

    Full Text Available Estudos recentes têm demonstrado que os bioflavonóides afetam vários sistemas enzimáticos nos mamíferos. A dura-máter é um tecido que recebe inervação peptidérgica. No cérebro, a inflamação neurogênica envolve a liberação da substância P (SP por terminais nervosos sensoriais e é modulada pela endopeptidase neutra (NEP e pela enzima conversora da angiotensina (ECA. Neste estudo, avaliamos o efeito da quercetina, que representa mais de 50% dos bioflavonóides, sobre o extravasamento plasmático induzido pela SP em tecidos selecionados no sistema nervoso central de ratos e dura-máter. Também examinamos o efeito da inibição seletiva das enzimas metabolizadoras da SP (NEP e ECA. A administração de SP (10 nmol/kg e 30 nmol/kg, i.v. aumentou o extravasamento plasmático de maneira dose dependente na duramáter, não apresentando nenhum efeito nos outros tecidos; este efeito foi potencializado por inibidores seletivos da NEP e da ECA. A quercetina (30 mg/kg v.o. aumentou o extravasamento plasmático em relação ao controle em todos os tecidos. O prétratamento com quercetina potenciou significativamente o extravasamento plasmático induzido pela SP (10 nmol/kg na dura-máter. Resultados obtidos com o pré-tratamento com antagonistas específicos para receptores da substância P e bradicinina (NK-1 e B2 sugerem que o aumento do extravasamento plasmático induzido pela quercetina e a potenciação da resposta à SP foram devidos ao acúmulo deste neuropeptídeo na dura-máter.

  4. A time and motion study of patients presenting at the accident and emergency department at Mater Dei Hospital

    Directory of Open Access Journals (Sweden)

    Ellul Robert

    2011-10-01

    Full Text Available Abstract Background To carry out a time and motion study of patients presenting at the Emergency Department (ED by measuring waiting times at the ED dept throughout the day. The objectives were: • to determine whether waiting times are prolonged, and • if prolonged, at which station(s bottlenecks occur most often in terms of duration and frequency. Results will be compared to the United Kingdom guidelines of stay at the emergency department. Methods A group of 11 medical students monitored all patients who attended ED between 0600 hours on the 25th August and 0600 hours on the 1st September 2008. For each 24 hour period, students were assigned to the triage room and the 3 priority areas where they monitored all patient-related activity, movement and waiting times so that length of stay (LOS could be recorded. The key data recorded included patient characteristics, waiting times at various ED process stages, tests performed, specialist consultations and follow up until admitted, discharged, or referred to another hospital area. Average waiting times were calculated for each priority area. Bottle-necks and major limiting factors were identified. Results were compared against the United Kingdom benchmarks - i.e. 1 hour until first assessment, and 4 hours before admitting/discharge. Results 1779 patients presented to the ED in the week monitored. As expected, patients in the lesser priority areas (i.e. 2 & 3 waited longer before being assessed by staff. Patients requiring laboratory and imaging investigations had a prolonged length of stay, which varied depending on specific tests ordered. Specialty consultation was associated with longer waiting times. A major bottleneck identified was waiting times for inpatient admission. Conclusions In conclusion, it was found that 30.3% of priority 1 patients, 86.3% of priority 2 patients and 76.8% of priority 3 patients waited more than 1 hour for first assessment. We conclude by proposing several changes that may expedite throughput.

  5. The Radiologist and the Magnetic Resonance Imaging Role in a Mater nal-Fe tal Multidisciplinary Unit

    International Nuclear Information System (INIS)

    The purpose of this review is to show the status of the Fetal Magnetic Resonance images in our institution. The fetal MR Imaging has become an important diagnostic tool in the world in the day to day clinical practice, when there is suspicion of any fetal pathology during pregnancy. The acquisition of new technology and the consolidation of the interdisciplinary groups, allow us to strengthen our knowledge in fetal MRI and improve every day in the acquisition of the images. The group of different disciplines including obstetrics, pediatric surgery, pediatric cardiology, pediatric neurology, perinatology, psychology, pathology, genetics, radiology and also MR technology with the same goal toward the early diagnosis of any fetal pathology contribute with the progress and confirmation of a difficult diagnosis in particular when there is any sonographic doubt of occult anomaly of the fetal brain or spine. We show some of our cases.

  6. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    Science.gov (United States)

    Chardonnet, Pascal

    2015-12-01

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d'Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet the extra-European connections with Brazil, China and India will be guaranteed: in China, with the Shanghai Observatory of the Chinese Academy of Science, studying the formation and evolution of large-scale structure and galaxies; in India, with the Indian Centre for Space Physics (ICSP), renowned for its research on compact objects as well as on solar physics and astrochemistry; in Brazil with ICRANet Brazil where a successful program of research and teaching in relativistic astrophysics has been established in recent years.

  7. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    Energy Technology Data Exchange (ETDEWEB)

    Chardonnet, Pascal [Coordinator IRAP PhD EMJD, Université de Nice 28, avenue Valrose 06103 Nice (France); LAPTh, Université de Savoie, CNRS, B.P. 110, Annecy-le-Vieux F-74941 (France); ICRANet, Piazza della Repubblica 10, 65122 Pescara (Italy); Department for Theoretical Nuclear Physics, National Research Nuclear University Moscow Engineering Physics Institute, MEPhI, Moscow (Russian Federation)

    2015-12-17

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d’Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet the extra-European connections with Brazil, China and India will be guaranteed: in China, with the Shanghai Observatory of the Chinese Academy of Science, studying the formation and evolution of large-scale structure and galaxies; in India, with the Indian Centre for Space Physics (ICSP), renowned for its research on compact objects as well as on solar physics and astrochemistry; in Brazil with ICRANet Brazil where a successful program of research and teaching in relativistic astrophysics has been established in recent years.

  8. EDITORIAL: Nanomemory: information and ingenuity Nanomemory: information and ingenuity

    Science.gov (United States)

    Demming, Anna

    2013-04-01

    Adv. Funct. Mater 20 330-7 [11] Bose S, Kim N H, Kuila T, Lau K-T and Lee J H 2011 Electrochemical performance of a graphene-polypyrrole nanocomposite as a supercapacitor electrode Nanotechnology 22 295202 [12] Loomis J, King B, Burkhead T, Xu P, Bessler N, Terentjev E and Panchapakesan B 2012 Graphene-nanoplatelet-based photomechanical actuators Nanotechnology 23 045501 [13] Finn C A 2001 Artifacts: An Archaeologist's Year in Silicon Valley (Cambridge, MA: MIT Press)

  9. First Principles Study of Dopant Site Selectivity in Ordered Perovskite CaCu3Ti4O12

    Institute of Scientific and Technical Information of China (English)

    XU Li-Chun; WANG Ru-Zhi; DENG Yang; YAN Hui

    2011-01-01

    We investigate the dopant site selectivity of CaCu3Ti4O12(CCTO) using the first principles calculations. Our results show that, for four cases of possible occupancy by La atom, lattice expansions and formation enthalpies with different dopant quantities indicate that doped La cations are preferentially substituted for Ca sites in CaCu3Ti4O12, which is excellent in agreement with the experimental observation(Choi et al. Adv. Mater. 21 (2009) 885).Furthermore, more interesting information of doping is also explored by the analysis of density of states and it is found that La substituting for Cu may advance the electron conduction in CCTO. It supplies a potential solution for limitations of CCTO devices by exploring the effect when La substitutes for Cu sites in the CCTO crystal.

  10. Quantum modelling of hydrogen chemisorption on graphene and graphite

    International Nuclear Information System (INIS)

    The chemisorption of hydrogen on graphene or graphite is studied within a quantum formalism involving a subsystem coupled to a phonon bath. The subsystem includes the hydrogen atom approaching the surface perpendicularly right on top of a carbon atom which puckers out of the surface. The bath includes the acoustic and optical phonon modes vibrating perpendicularly to the surface. Couplings between subsystem and bath are obtained with a periodic density functional theory calculation. Trapping probabilities are obtained as a function of the hydrogen atom kinetic energy. These results are discussed in the light of the experimental hydrogenation studies performed on graphite by Zecho et al. [J. Chem. Phys. 117, 8486 (2002)] and on graphene by Haberer et al. [Adv. Mater. 23, 4497 (2011)

  11. Conjugated Polymers for Energy Production

    DEFF Research Database (Denmark)

    Livi, Francesco

    This dissertation is aimed at developing materials for flexible, large area, ITO-free polymer solar cells (PSCs) fully printed under ambient conditions. A large screening of conjugated polymers, both novel and well-known materials, has been carried out in order to find suitable candidates...... for scalable PSCs fully printed under ambient conditions [Adv. Energy Mater. 2015, 5, 1402186]. PPDTBT resulted to be the conjugated polymer with the best photovoltaic performance within the 104 synthesized macromolecules. Therefore, further studies have been done on such material. The impact of side chain...... arylation (DAr) and direct arylation polymerization (DArP) have been applied to the preparation of PPDTBT, making this polymer readily available in only 4 synthetic steps and thus easily transferable to a large scale-production setup. DArP avoids organometallic species and therefore is an appealing...

  12. Approach to tune near- and far-field properties of hybrid dimer nanoantennas via laser melting at the nanoscale

    CERN Document Server

    Sun, Yali; Zuev, Dmitry; Huang, Lirong; Krasnok, Alexander; Belov, Pavel

    2016-01-01

    Asymmetric metal-dielectric nanostructures are demonstrated superior optical properties arise from the combination of strong enhancement of their near fields and controllable scattering characteristics which originate from plasmonic and high-index dielectric components. Here, being inspired by the recent experimental work [Dmitry~Zuev, \\textit{et al.}, Adv. Mater. \\textbf{28}, 3087 (2016)] on a new technique for fabrication of asymmetric hybrid nanoparticles via femtosecond laser melting at the nanoscale, we suggest and study numerically a novel type of hybrid dimer nanoantennas. The nanoantennas consist of asymmetric metal-dielectric (Au/Si) nanoparticles and can allow tuning of the near- and far-field properties via laser melting of the metal part. We demonstrate a modification of scattering properties, near electric field distribution, normalized local density of states, and power patters of radiation of the nanoantennas upon laser reshaping. The parameters used to investigate these effects correspond to e...

  13. Dominance of interface chemistry over the bulk properties in determining the electronic structure of epitaxial metal/perovskite oxide heterojunctions

    Energy Technology Data Exchange (ETDEWEB)

    Chambers, Scott A.; Du, Yingge; Gu, Meng; Droubay, Timothy C.; Hepplestone, Steven; Sushko, Petr

    2015-06-09

    We show that despite very similar crystallographic properties and work function values in the bulk, epitaxial Fe and Cr metallizations on Nb:SrTiO3(001) generate completely different heterojunction electronic properties. Cr is Ohmic whereas Fe forms a Schottky barrier with a barrier height of 0.50 eV. This contrast arises because of differences in interface chemistry. In contrast to Cr [Chambers, S. A. et al., Adv. Mater. 2013, 25, 4001.], Fe exhibits a +2 oxidation state and occupies Ti sites in the perovskite lattice, resulting in negligible charge transfer to Ti, upward band bending, and Schottky barrier formation. The differences between Cr and Fe are understood by performing first-principles calculations of the energetics of defect formation which corroborate the observed interface chemistry and structure.

  14. Particle processing technology

    Science.gov (United States)

    Yoshio, Sakka

    2014-02-01

    . Mater. 12 013001 [3] Sakka Y and Uchikoshi T 2010 KONA Powder Particle J. 28 74 (kona.or.jp/search/28_074.pdf) [4] Naguib M, Mashtalir O, Carle J, Presser V, Lu J, Hultman L, Gogotsi Y and Barsoum M W 2012 ACS Nano 6 1322 [5] Sakka Y and Suzuki T S 2005 J. Ceram. Soc. Japan 113 26 [6] Grasso S, Sakka Y and Maizza G 2009 Sci. Technol. Adv. Mater. 10 053001 [7] Nakao H, Tokonami S, Hamada T, Shiigi H, Nagaoka T, Iwate F and Takeda Y 2012 Nanoscale 4 6814 [8] Miyazawa K and Hotta K 2010 J. Cryst. Growth 312 2764 [9] Suehiro T, Xie R and Hirosaki N 2013 Indust. Eng. Chem. Res. 52 7453 [10] Zhu Q, Li J-G, Li X, Sun X and Sakka Y 2011 Sci. Technol. Adv. Mater. 12 055001 [11] Li J, Li J-G, Zhang Z, Wu X, Liu S, Li X, Sun X and Sakka Y 2012 Sci. Technol. Adv. Mater. 13 035007 [12] Kawamura F, Yusa H and Taniguchi T 2012 Appl. Phys. Lett. 100 251910 [13] Watanabe K and Taniguchi T 2011 Int. J. Appl. Ceram. Technol. 8 977 [14] Deng Z-Y, Ferreira J M F and Sakka Y 2008 J. Am. Ceram. Soc. 91 3825 [15] Uda M, Okuyama H, Suzuki T S and Sakka Y 2012 Sci. Technol. Adv. Mater. 13 025009 [16] Takeya H, Kato R, Wakahara T, Miyazawa K, Yamaguchi T, Ozaki T, Okazaki H and Takano Y 2013 Mater. Res. Bull. 48 343 [17] Wakahara T, D'Angelo P, Miyazawa K, Nemoto Y, Ito O, Tanigaki N, Bradley D D C and Anthopoulos T D 2012 J. Am. Chem. Soc. 134 7204 [18] Wiecinska P, Sakka Y, Suzuki T S, Uchikoshi T, Mizerski T and Szafran M 2013 J. Ceram. Soc. Japan 121 89 [19] Kawakita M, Uchikoshi T, Kawakita J and Sakka Y 2009 J. Am. Ceram. Soc. 92 984 [20] Hu C, Sakka Y, Grasso S, Nishimura T, Guo S and Tanaka H 2011 Scr. Mater. 64 765 [21] Hu C, Sakka Y, Nishimura T, Guo S, Grasso S and Tanaka H 2011 Sci. Technol. Adv. Mater. 12 044603 [22] Kakisawa H and Sumitomo T 2011 Sci. Technol. Adv. Mater. 12 064710 [23] Grasso S, Hu C F, Maizza G, Kim B N and Sakka Y 2011 J. Am. Ceram. Soc. 94 1405 [24] Grasso S, Kim B N, Hu C F, Maizza G and Sakka Y 2010 J. Am. Ceram. Soc. 93 2460 [25] Zhang H B, Kim B N, Morita K

  15. Chinese herbal medicine combined with nucleotide analogues for compensated HBV-related cirrhosis: a systematic review of randomized controlled trials

    Directory of Open Access Journals (Sweden)

    Tingting Li

    2015-01-01

    Conclusions: A positive effect was found for FFBJ plus ETV, DHZC plus ADV, and FZHY plus ADV on HA; FZHY plus ADV and FFBJ plus ADV on LN; and FZHY plus ADV on PCIII compared with the effects of NAs used alone.

  16. Colossal dielectric constant in high entropy oxides

    Energy Technology Data Exchange (ETDEWEB)

    Berardan, David; Franger, Sylvain; Dragoe, Diana; Meena, Arun Kumar; Dragoe, Nita [ICMMO (UMR 8182 CNRS), Universite Paris-Sud, Universite Paris-Saclay, 91405, Orsay (France)

    2016-04-15

    Entropic contributions to the stability of solids are very well understood and the mixing entropy has been used for forming various solids, for instance such as inverse spinels, see Nawrotsky et al., J. Inorg. Nucl. Chem. 29, 2701 (1967) [1]. A particular development was related to high entropy alloys by Yeh et al., Adv. Eng. Mater. 6, 299 (2004) [2] and Cantor et al., Mater. Sci. Eng. A 375-377, 213 (2004) [3] (for recent reviews see Zhang et al., Prog. Mater. Sci. 61, 1 (2014) [4] and Tsai et al., Mater. Res. Lett. 2, 107 (2014) [5]) in which the configurational disorder is responsible for forming simple solid solutions and which are thoroughly studied for various applications especially due to their mechanical properties, e.g. Gludovatz et al., Science 345, 1153 (2014) [6] and Lu et al., Sci. Rep. 4, 6200 (2014) [7], but also electrical properties, Kozelj et al., Phys. Rev. Lett. 113, 107001 (2014) [8], hydrogen storage, Kao et al., Int. J. Hydrogen Energy 35, 9046 (2010) [9], magnetic properties, Zhang et al., Sci. Rep. 3, 1455 (2013) [10]. Many unexplored compositions and properties still remain for this class of materials due to their large phase space. In a recent report it has been shown that the configurational disorder can be used for stabilizing simple solid solutions of oxides, which should normally not form solid solutions, see Rost et al., Nature Commun. 6, 8485 (2015) [11] these new materials were called ''entropy-stabilized oxides''. In this pioneering report, it was shown that mixing five equimolar binary oxides yielded, after heating at high temperature and quenching, an unexpected rock salt structure compound with statistical distribution of the cations in a face centered cubic lattice. Following this seminal study, we show here that these high entropy oxides (named HEOx hereafter) can be substituted by aliovalent elements with a charge compensation mechanism. This possibility largely increases the potential development of new

  17. Review of corrosion behavior of ceramic heat exchanger materals: Corrosion characteristics of silicon carbide and silicon nitride. Final report, September 11, 1992--March 11, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Munro, R.G.; Dapkunas, S.J.

    1993-09-01

    The present work is a review of the substantial effort that has been made to measure and understand the effects of corrosion with respect to the properties, performance, and durability of various forms of silicon carbide and silicon nitride. The review encompasses corrosion in diverse environments, usually at temperatures of 1000C or higher. The environments include dry and moist oxygen, mixtures of hot gaseous vapors, molten salts, molten metals, and complex environments pertaining to coal ashes and slags.

  18. El «Stabat Mater» glosado y traducido por sor María Gertrudis de la Cruz Hore a fines del siglo XVII

    Directory of Open Access Journals (Sweden)

    Morand, Frédérique

    2006-12-01

    Full Text Available The essay gives us new information about the most famous Gertrudis Hore’s creation, profess in the Concepcionist convent of Santa María in Cádiz, and her several editions. For the first time, we find out the fraud literary and copy of this shrewd poetess, however, at the same time, a really interesting melting between prose, poem and holy music on tightening liturgical period normally distant. In this writing, typical of Virgin literature, a continually using of feminine references do innovation form’s to this text.El artículo da a conocer esta olvidada creación y sus distintas ediciones, el mayor éxito literario de María Gertrudis Hore, religiosa Concepcionista Calzada en Cádiz. Se descubre, por vez primera, la superchería de la astuta erudita, a la vez que la interesante fusión literaria realizada entre prosa, verso y música sacra al estrechar hábilmente dos tiempos litúrgicos habitualmente distantes. En este escrito propiamente inmaculista, el uso continuo del referente femenino destaca por su novedad.

  19. Celulares: a emergência de um novo tipo de controle materno Cell phones: the emergence of a new king of materal control

    Directory of Open Access Journals (Sweden)

    Ana Maria Nicolaci-da-Costa

    2006-12-01

    Full Text Available Em uma pesquisa exploratória sobre o uso de celulares por jovens das camadas médias cariocas, entre 18 e 25 de idade, foi constatado que eles reclamavam muito que suas mães os controlavam ininterruptamente por meio de seus celulares. Para averiguar mais detalhadamente o que acontece entre mães e filhos dessa faixa etária, foi realizada uma segunda pesquisa. Nesta, foram entrevistadas 20 mães, também pertencentes às camadas médias cariocas, cujos filhos tinham perfil análogo ao dos jovens da primeira pesquisa. Para todas, a principal função dos celulares é abertamente a de controlar os filhos. Elas mostraram, no entanto, saber que há uma diferença entre o controle que vigorava quando eram jovens e aquele ao qual hoje submetem os filhos. Teorias contemporâneas sobre controle e vigilância de fato argumentam que houve uma substituição do controle normativo e coercitivo da modernidade pelo "ter conhecimento" do que se passa, característico da Era da Informação.An exploratory research on the use of cell phones by middle-class youngsters, ages 18 to 25, residing in Rio de Janeiro, revealed that they complained a great deal that their mothers controlled them unrelentingly by means of cell phones. To take a deeper look into what happens between mothers and children in this age group, a second investigation was carried out. Twenty middle-class mothers were interviewed, whose children's profile were analogous to that of the youngsters in the previous research. For all of the mothers, the main benefit of cell phones is to control their children. Nevertheless, they demonstrated to know that there's a difference between the control that they submit their children to from that that prevailed when they themselves were young. Contemporary control and surveillance theories, in fact, argue that the normative and coercive control of modernity has been replaced by "having knowledge" of what goes on, which is characteristic of the Information Era.

  20. 冻干辐照猪硬脑膜的抗原性%Antigenicity of freeze-dried irradiated pig dura mater

    Institute of Scientific and Technical Information of China (English)

    张友来; 曾元临; 邹立津; 辛国华

    2010-01-01

    背景:抗原性是异种组织移植最主要的问题,是移植成功与否的关键.目的:观察经冻干辐照处理后的猪硬脑膜抗原性变化.方法:取新鲜猪硬脑膜,经冻干、辐照处理后分别制备成冻干猪硬脑膜、辐照猪硬脑膜和冻干辐照猪硬脑膜.分别移植于大白兔硬脑膜上,于术后3,8周行各组实验动物淋巴细胞毒实验.结果与结论:移植冻干组和辐照组淋巴细胞死亡率比较差异无显著性意义(P>0.05),但均高于冻干辐照组(P<0.05).结果提示经冻干辐照处理后的猪硬脑膜抗原性低.

  1. Poisson formulas for circular functions on some groups of type H

    Institute of Scientific and Technical Information of China (English)

    KORáNYI; Adam

    2006-01-01

    [1]Gaveau B,Greiner P,Vauthier J.Polyn(o)mes harmoniques et problème de Dirichlet de la boule du groupe de Heisenberg en présence de symétrie radiale.Bull Sc Math,1984,108:337-354[2]Korányi A,Reimann H M.Horizontal normal vectors and conformal capacity of spherical rings in the Heisenberg group.Bull Sc Math,1987,111:3-21[3]Kaplan A.Fundamental solutions for a class of hypoelliptic PDE generated by composition of quadratic forms.Trans AMS,1980,258:147-153[4]Garofalo N,Vassilev D.Symmetry properties of positive solutions of Yamabe-type equations on groups of Heisenberg type.Duke Math J,2001,106:411-448[5]Gaveau B.Principe de moindre action,propagation da la chaleur et estimées sous-elliptiques sur certains groupes nilpotents.Acta Math,1977,139:95-153[6]Cowling M,Dooley A H,Korányi A,et al.H-type groups and Iwasawa decompositions.Adv Math,1991,87:1-41[7]Erdélyi A,et al.Higher transcendental functions.New York:McGraw-Hill,1953[8]Korányi A.Kelvin transforms and harmonic polynomials on the Heisenberg group.J Funct Analysis,1982,49:177-185[9]Garofalo N,Vassilev D.Regularity near the characteristic set in the non-linear Dirichlet problem and conformal geometry of sub-Laplacians on Carnot groups.Math Ann,2000,318:453-516

  2. Drug: D01421 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available purate sodium; Paraaminohippurate (TN) C9H9N2O3. Na 216.0511 216.1691 D01421.gif Diagnostic aid [renal funct...ly for therapeutic purpose 72 Intracorporeal diagnostic agents 722 Various function testing reagents 7225 Diagnostic

  3. Plasmon resonant gold-coated liposomes for spectrally controlled content release

    Science.gov (United States)

    Leung, Sarah J.; Bobnick, Michael C.; Romanowski, Marek

    2010-02-01

    We recently demonstrated that liposome-supported plasmon resonant gold nanoshells are degradable into components of a size compatible with renal clearance, potentially enabling their use as multifunctional agents in applications in nanomedicine, including imaging, diagnostics, therapy, and drug delivery (Troutman et al., Adv. Mater. 2008, 20, 2604-2608). When illuminated with laser light at the wavelength matching their plasmon resonance band, gold-coated liposomes rapidly release their encapsulated substances, which can include therapeutic and diagnostic agents. The present research demonstrates that release of encapsulated agents from gold-coated liposomes can be spectrally controlled by varying the location of the plasmon resonance band; this spectral tuning is accomplished by varying the concentration of gold deposited on the surface of liposomes. Furthermore, the amount of laser energy required for release is qualitatively explained using the concept of thermal confinement (Jacques, Appl. Opt. 1993, 32(3), 2447-2454). Overlapping thermal confinement zones can be avoided by minimizing the laser pulse width, resulting in lower energy requirements for liposomal content release and less global heating of the sample. Control of heating is especially important in drug delivery applications, where it enables spatial and spectral control of delivery and prevents thermal damage to tissue.

  4. Multiscale Homogenization Theory: An Analysis Tool for Revealing Mechanical Design Principles in Bone and Bone Replacement Materials

    Science.gov (United States)

    Hellmich, Christian; Fritsch, Andreas; Dormieux, Luc

    Biomimetics deals with the application of nature-made "design solutions" to the realm of engineering. In the quest to understand mechanical implications of structural hierarchies found in biological materials, multiscale mechanics may hold the key to understand "building plans" inherent to entire material classes, here bone and bone replacement materials. Analyzing a multitude of biophysical hierarchical and biomechanical experiments through homogenization theories for upscaling stiffness and strength properties reveals the following design principles: The elementary component "collagen" induces, right at the nanolevel, the mechanical anisotropy of bone materials, which is amplified by fibrillar collagen-based structures at the 100-nm scale, and by pores in the micrometer-to-millimeter regime. Hydroxyapatite minerals are poorly organized, and provide stiffness and strength in a quasi-brittle manner. Water layers between hydroxyapatite crystals govern the inelastic behavior of the nanocomposite, unless the "collagen reinforcement" breaks. Bone replacement materials should mimic these "microstructural mechanics" features as closely as possible if an imitation of the natural form of bone is desired (Gebeshuber et al., Adv Mater Res 74:265-268, 2009).

  5. Molecular structure of the discotic liquid crystalline phase of hexa-peri-hexabenzocoronene/oligothiophene hybrid and their charge transport properties

    Energy Technology Data Exchange (ETDEWEB)

    Bag, Saientan; Maingi, Vishal; Maiti, Prabal K., E-mail: maiti@physics.iisc.ernet.in [Department of Physics, Center for Condensed Matter Theory, Indian Institute of Science, Bangalore 560012 (India); Yelk, Joe; Glaser, Matthew A.; Clark, Noel A. [Department of Physics, University of Colorado, Boulder, Colorado 80309 (United States); Walba, David M. [Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309 (United States)

    2015-10-14

    Using atomistic molecular dynamics simulation, we study the discotic columnar liquid crystalline (LC) phases formed by a new organic compound having hexa-peri-Hexabenzocoronene (HBC) core with six pendant oligothiophene units recently synthesized by Nan Hu et al. [Adv. Mater. 26, 2066 (2014)]. This HBC core based LC phase was shown to have electric field responsive behavior and has important applications in organic electronics. Our simulation results confirm the hexagonal arrangement of columnar LC phase with a lattice spacing consistent with that obtained from small angle X-ray diffraction data. We have also calculated various positional and orientational correlation functions to characterize the ordering of the molecules in the columnar arrangement. The molecules in a column are arranged with an average twist of 25° having an average inter-molecular separation of ∼5 Å. Interestingly, we find an overall tilt angle of 43° between the columnar axis and HBC core. We also simulate the charge transport through this columnar phase and report the numerical value of charge carrier mobility for this liquid crystal phase. The charge carrier mobility is strongly influenced by the twist angle and average spacing of the molecules in the column.

  6. Effect of functionalization on the electronic and atomic properties of layered MXenes

    Science.gov (United States)

    Fredrickson, Kurt; Vojvodic, Aleksandra; Nørskov, Jens

    MXenes (M = Transition Metal, X = C or N) are a promising family of materials that have been recently manufactured from MAX phases. MXenes have already been shown as promising candidates for use in lithium ion batteries, supercapacitors, and fuel cells (1). MXenes consist of M_(x)X_(x-1), two-dimensional sheets weakly bound by van der Waals forces. However, due to the selective removal of the A ion to manufacture MXenes, they are highly reactive, with a wide variety of possible functional groups. Previous studies have shown that the electronic properties of MXene single sheets are highly dependent on their functionalization, but so far there are few studies on the effect of functionalization of the bulk phase of MXene, which consists of many layers of MXenes bound together. In this talk, we will illustrate the effect of functionalization of bulk MXenes by H, H2, OH, and O for Mo2C and Ti2C. We will also show the effect of applied potential on the functionalization of Mo2C and Ti2C. Finally, we will compare our results with experimental measurements. (1) M. Naguib, V.D. Mochalin, M.W. Barsoum and Y. Gogotsi, Adv. Mater. 26, 992 (2014).

  7. Electroactive-Zone Extension in Flow-Battery Stacks

    Energy Technology Data Exchange (ETDEWEB)

    Smith, KC; Brunini, VE; Dong, YJ; Chiang, YM; Carter, WC

    2014-11-20

    Flowable suspensions that conduct both electrons and ions can enable the use of energy-dense electroactive species in flow batteries [M. Duduta et al., Adv. Energy Mater., 1, 511 (2011); Z. Li et al., Phys. Chem. Chem. Phys., 15, 15,833 (2013); F. Fan et al., Nano Lett., 14, 2210 (2014)]. In comparison with conventional flow batteries where electrochemical reactions are confined to a fixed current-collector region, electronically conductive flow electrodes permit electrochemical reactions to extend outside of the physical confines of the stack. We have measured and modeled how mixed-conduction enables an electroactive zone (EAZ, in which electrochemical reactions occur) that is of greater spatial extent than current collectors, the extension being termed side zone, SZ. Electrochemical reactions in SZs can reduce coulombic and energetic efficiency. Here we show that for realistic suspension properties and operating conditions, the added inefficiency is small in practice, and can be further mitigated by using appropriate operating conditions and/or materials choices. For the specific example of a non-aqueous Li4Ti5O12 suspension, we show that EAZ extension contributes less than 1% additional efficiency loss at C/10 rates for current collectors greater than 20 mm long. (C) 2014 Elsevier Ltd. All rights reserved.

  8. Structural stability study of protein monolayers in air

    Science.gov (United States)

    Pompa, P. P.; Biasco, A.; Cingolani, R.; Rinaldi, R.; Verbeet, M. Ph.; Canters, G. W.

    2004-03-01

    The assessment of the folding and of the structural stability of a protein in air, upon immobilization in the solid state, represents a critical point from both a fundamental point of view and for the development of solid state nanobioelectronics. The recent demonstrations by Rinaldi et al. [R. Rinaldi et al., Adv. Mater. 14, 1453 (2002); Appl. Phys. Lett. 82, 472 (2003); Ann. (N.Y.) Acad. Sci. 1006, 187 (2003)] of protein-based solid state devices and transistors working in air have raised an intriguing question about the behavior of a biomolecule under nonphysiological conditions. The operation principle of the realized devices is based on the physiological electron transfer function of the metalloprotein azurin. This means that azurin should retain its shape and functionality also in the solid state when utilized in air and at room temperature. In this Brief Report, we prove this claim by analyzing the conformational state of the azurin monolayers developed for such devices by means of intrinsic fluorescence spectroscopy. We show that the immobilization of azurins in the solid state under nonliquid conditions, by means of a specific chemisorption process, does not necessarily lead to protein denaturation. This result is of great importance because it opens up interesting perspectives for the development of solid state hybrid nanodevices for electronic applications requiring nonliquid environments.

  9. 国外文献速报

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Gunduz M,Cadirli E.Pb-Sn合金的定向凝固(英).J.Mater.Sci.,2000,35 (15):3837~3848 040113 Nave M D,Dahle A K,John D H St.凝固速度对镁合金共晶晶粒组织的影响(英).Int.J.Cast Met.Res.,2000,13 (1):1~7 040114 Martorano M A,Capoccli J D T.定向凝固青铜铸件枝晶组织的控制(英).Int.J.Cast Met.Res.,2000,13(1): 49~57 040115 Zhang Y L,Li Q,Li Y X.NiAl形状记忆合金的单晶生长(英).Prog.Cryst.Growth Charact.Mater.,2000,4(1-4): 309~314 040116 Cheng T T.TiAl合金中添加B细化晶粒的机理-- 一种可选择的假设(英).Intermatallics,2000,8(1): 29~31 040117 Pao P S,Feng C K,Gill S J.关于7075-T7351合金从腐蚀凹坑开始时的裂纹(英).Scr.Mater.,2000,43(5):391~396 040118 Hilpert M,Wagner L.高强度镁合金AZ80的腐蚀疲劳行为(英).J.Mater.Eng.Perform.,2000,9(4): 402~407 040119 Sasaki G,Fukunaga H,Yoshida M.镁基复合材料的制造工艺及微观组织分析(英).Mater.Jpn.,2000,39(6): 519~525 040120 Kosec B,Bizjak M,Kosec L.两相铜基材料拉伸变形的宏观模拟(英).Metall.2000,69(5):384~386 040121 Machovec C J,Zindel J W,Godlewski L A.Bi-Sr复合变质对319铝合金中Si形态影响的效果分析(英).Mod.Cast.,2000(6):42~44 040122 Maeng D Y,Chun B S,Hong H J.快速凝固挤压Mg-Zn合金的组织和强度(英).Scr.Mater.,2000,43(5):385~389 040123 Kim H G,Kim J Y,Cho Y T.预应变对形状记忆合金弹性的影响分析研究(英).Key Eng.Mater.,2000 (2):1219~1224 040124 Cho W D,Kim I,Kim H J.含Y的Fe3Al的高温氧化(英).J.Mater.Sci.,2000,35 (18): 4695~4703 金属基复合材料 040201 Hirai H,Kitahara A,Tabarn T.定向凝固No-xMo-22Ti-18Si原位(In-Stiu)复合材料的组织和力学性能(日).J.Jpn.Inst.Met.,2000,64(6): 474~480 040202 Korner C,Ottmuller M,Schaff W.碳长纤维增强镁基复合材料(英).Adv.Eng.Mater.,2000,2(6): 327~337 040203 Naplocha K,Samsonowicz Z.AlSi9Mg基Al2O3短纤维增强复合材料(葡).Przegl.Odlew.,2000,50(4):127~130 040204 Lee J C

  10. "La Iglesia, vaso siempre joven del Espíritu de Dios" (Adv. haer. 111,24, 1): Reflexiones sobre el núcleo articulador de la eclesiología de San Ireneo de Lyon

    OpenAIRE

    Rodrigo Polanco F

    2007-01-01

    El autor presenta el núcleo articulador de la eclesiología de San Ireneo. Frente a la teología gnóstica que negaba la bondad de la creación, y particularmente la corporalidad (carne) humana, Ireneo presenta una eclesiología que es consecuencia de su cristología y antropología que valoran tanto al hombre en su corporalidad, como la realidad de la encarnación. En consecuencia, la eclesiología de Ireneo se fundamenta en la bondad de la institución eclesial que es instrumento del Espíritu. El Esp...

  11. Sujeito da enunciação: singularidade que advém da sintaxe da enunciação Enunciative subject: singularity derived from the enunciative syntax

    Directory of Open Access Journals (Sweden)

    Valdir do Nascimento Flores

    2013-01-01

    Full Text Available Este texto, a partir da leitura da teoria enunciativa criada por Émile Benveniste, desenvolve a noção de sujeito da enunciação ligando-a, metodologicamente, à noção de sintaxe de enunciação como forma de propor uma possibilidade de análise de fatos de língua. O texto ilustra a proposta metodológica em um dado de linguagem infantil.This text, based on the reading of the enunciative theory created by Emile Benveniste, develops the notion of enunciative subject, methodologically linking it to the notion of enunciative syntax in order to propose a possibility for analyzing facts of language. The text illustrates this methodological proposal using data from child language.

  12. "La Iglesia, vaso siempre joven del Espíritu de Dios" (Adv. haer. 111,24, 1: Reflexiones sobre el núcleo articulador de la eclesiología de San Ireneo de Lyon

    Directory of Open Access Journals (Sweden)

    Rodrigo Polanco F

    2007-01-01

    Full Text Available El autor presenta el núcleo articulador de la eclesiología de San Ireneo. Frente a la teología gnóstica que negaba la bondad de la creación, y particularmente la corporalidad (carne humana, Ireneo presenta una eclesiología que es consecuencia de su cristología y antropología que valoran tanto al hombre en su corporalidad, como la realidad de la encarnación. En consecuencia, la eclesiología de Ireneo se fundamenta en la bondad de la institución eclesial que es instrumento del Espíritu. El Espíritu de Cristo se hace presente a través de los carismas y de la sucesión apostólica que transmiten la comun1Cación auténtica de Cristo. Es en síntesis una eclesiología del Espíritu encarnado en la estructura de la Iglesia, Espíritu que hace a esta misma Iglesia fiable y fiel al mensaje y persona de JesucristoThe author presents the articulating nucleus of the ecclesiology of St. Irenaeus. In the context of Gnostic theology that denies the goodness of creation, and particularly of human (flesh corporality, Irenaeus presents an ecclesiology that is a consequence of his Christology and his anthropology, which values man as much in his corporality as in the reality of the Incarnation. As a consequence, Irenaeus' ecclesiology is founded upon the goodness of the ecclesial institution that is an instrument of the Spirit. The Spirit of Christ makes itself present through charisms and through the apostol1C succession, that transmit the authentic commun1Cation of Christ. In synthesis, it is an ecclesiology of the Spirit incarnated in the structure of the Church, Spirit that makes this same Church worthy of trust and faithful to the message and person of Jesus Christ

  13. New treatment option for women with hormone-sensitive breast cancer

    Science.gov (United States)

    A drug used for treating breast cancer, known as exemestane, is more effective than a common breast cancer prevention drug, tamoxifen, in preventing breast cancer recurrence in young women who also receive post-surgical treatment to suppress ovarian funct

  14. Treatment-related changes in functional connectivity in brain tumor patients : a magnetoencephalography study

    NARCIS (Netherlands)

    Douw, Linda; Baayen, Hans; Bosma, Ingeborg; Klein, Martin; Vandertop, Peter; Heimans, Jan; Stam, Kees; de Munck, Jan; Reijneveld, Jaap

    2008-01-01

    Widespread disturbances in resting state functional connectivity between remote brain areas have been demonstrated in patients with brain tumors. Functional connectivity has been associated with neurocognitive deficits in these patients. Thus far, it is unknown how (surgical) treatment affects funct

  15. InterProScan Result: FS736777 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 05804 Fatty acid desaturase, type 1 Biological Process: lipid metabolic process (GO:0006629)|Molecular Funct...ion: oxidoreductase activity (GO:0016491)|Biological Process: oxidation reduction (GO:0055114) ...

  16. InterProScan Result: FS765138 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 05804 Fatty acid desaturase, type 1 Biological Process: lipid metabolic process (GO:0006629)|Molecular Funct...ion: oxidoreductase activity (GO:0016491)|Biological Process: oxidation reduction (GO:0055114) ...

  17. InterProScan Result: FS765139 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS765139 FS765139_3_ORF2 28254415478F6640 PANTHER PTHR11939:SF94 CALCIUM-TRANSPORTI...NG ATPASE SARCOPLASMIC/ENDOPLASMIC RETICULUM TYPE (CALCIUM PUMP) NA ? IPR008250 unintegrated Molecular Funct

  18. NEUROLOGICAL DISORDER

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    13.1 Neuroanatomy, Neurophysiology and Neuropathology2007131 Study on decision-making alternation after bilateral nucleus accumbens ablation in drug addicts. HOU Yuan-zheng(侯远征),et al. Dept Neurosurg, Instit Funct Neurosurg, Instit Funct Cerebullar Dis, Tangdu Hosp, 4th Milit Med Univ, Xi′an 710038. Chin J Nerv Ment Dis 2006;32(6)494-497. Objective To explore decision-making alternation after bilateral nucleus accumbens ablation in drug addicts and analyse the reason.

  19. THE EFFECTS OF NF-KB ON ICAM-1 PROTEIN EXPRESSIONS OF RAT DURA MATER WITH MIGRAINE%NF-κB上调偏头痛大鼠脑膜ICAM-1蛋白表达

    Institute of Scientific and Technical Information of China (English)

    何秋; 王怀良; 章新华; 陈磊

    2007-01-01

    目的:探讨核转录因子-κB(nuclear factor-kappa B,NF-κB)在偏头痛脑膜炎症反应中的作用及细胞间黏附分子-1(intercellular adhesion molecules-1,ICAM-1)表达的调控机制.方法采用静脉注射(iv)硝酸甘油(glyceryl trinitrate,GTN)法建立大鼠偏头痛模型,分为对照组、模型组、溶剂对照组、吡咯烷二硫氨基甲酸(pyrrolidine dithiocarbamate,PDTC)组.各组分别包括0.9%生理盐水或GTN iv后1.5,4h两个实验小组.应用Western印迹法分别观察PDTC对GTN iv后1.5h大鼠脑膜NF-κB蛋白表达水平与GTN iv后4h ICAM-1蛋白表达水平的影响.结果:PDTC 50,100,200 mg.kg-1各剂量组GTN iv后1.5h大鼠脑膜NF-κB蛋白表达量较模型组分别降低30%(P<0.05)、52%(P<0.01)和65%(P<0.01),呈剂量依赖性;PDTC 50,100,200 mg.kg-1各剂量组GTN iv后4h大鼠脑膜ICAM-1蛋白表达量较模型组分别降低36%(P<0.05)、71%(P<0.01)和51%(P<0.01),无剂量依赖关系.结论:NF-κB参与偏头痛时脑膜ICAM-1的蛋白合成调控,在偏头痛的脑膜炎症机制中起着重要作用.

  20. 播种方式对大豆干物质积累与产量影响的研究%Effect of Sowing Methods on Dry Mater Accumulation and Yield in Soybean

    Institute of Scientific and Technical Information of China (English)

    徐文平; 苗兴芬; 任学坤; 申宏波

    2008-01-01

    试验采用5个处理,3次重复,研究了不同播种方式对大豆干物质积累与产量的影响.结果表明:穴距18 cm,每穴3株的播种方式对于干物质的积累较为合适.不同处理对大豆产量性状的影响不同,穴距18 cm,每穴3株的播种方式大豆产量最高,大豆产量与株高、主茎节数、单株生产力及单株荚数呈正相关,而与百粒重呈不显著的负相关.

  1. 弱光胁迫对超级杂交稻产量和干物质积累的影响%Effects of weak light stress on grain yield and dry mater accumulation of super hybrid rice

    Institute of Scientific and Technical Information of China (English)

    刘科; 何爱斌; 苑涛涛; 田小海; 张运波

    2014-01-01

    超级杂交稻在山丘地区的生态条件下容易展示超高产潜力,但在平原地区由于光照相对较少和灌浆期间的多阴寡照天气造成严重减产.以超级杂交稻、普通杂交稻和高产常规稻代表品种为供试材料,在齐穗后设置过滤30%光照、60%光照和对照3个处理,探讨不同遮光处理对超级杂交稻产量和干物质积累的影响.结果表明:超级杂交稻对弱光反应敏感,品种和遮光处理之间互作效应显著,齐穗后遮光处理对超级杂交稻结实率和千粒重影响显著、产量下降24.2%~52.8%,对每穗粒数和有效穗数影响不显著;齐穗后遮光处理对超级杂交稻干物质积累影响显著,收获指数显著下降,特别是后期干物质积累量占总干物质比例显著下降,影响后期干物质的积累和转化.

  2. Comment on "High-temperature soft magnetic properties of antiperovskite nitrides ZnNFe3 and AlNFe3" by Yankun Fu, Shuai Lin, and Bosen Wang, J. Magn. Magn. Mater. 378 (2015) 54-58

    Science.gov (United States)

    Scholz, T.; Leineweber, A.; Dronskowski, R.

    2016-10-01

    The authors of the aforementioned manuscript have recently claimed the synthesis of the ternary nitrides ZnNFe3 (=ZnFe3N) and AlNFe3 (=AlFe3N), ordered substituted variants of the binary phase γ'-Fe4N [1]. While soft ferromagnets of such kind are presently attracting lots of attention, their history dates back for more than half a century. In particular, Al-substituted γ'-Fe4N has already been mentioned in 1961 [2], and the existence of AlFe3N has also been claimed in 2009 [3] from a two-step ammonolysis reaction combining a high-temperature sintering step and a low-temperature nitriding reaction [4]. Nonetheless, one of us had to withdraw the latter claim after finding out, by means of scanning-electron microscopy and elemental mapping, that all samples of "AlFe3N" consisted of an intimate solid mixture of γ'-Fe4N and amorphous Al2O3[5]. From what follows, we have strong reasons to believe that the authors of Ref. [1] overlooked our findings [5] and also did not synthesize ZnFe3N and AlFe3N.

  3. Central limit theorem for integrated square error of kernel estimators of spherical density

    Institute of Scientific and Technical Information of China (English)

    ZHAO; Lincheng

    2001-01-01

    [1] Cruzeiro, A. B., Malliavin, P., Renormalized differential geometry on path spaces: Structural equation, curvature, J. Funct. Anal., 1996, 139: 119-181.[2] Stroock, D. W., Some thoughts about Riemannian structures on path spaces, preprint, 1996.[3] Driver, B., A Cameron-Martin type quasi-invariance theorem for Brownian motion on a compact manifold, J. Funct. Anal., 1992, 109: 272-376.[4] Enchev, O., Stroock, D. W., Towards a Riemannian geometry on the path space over a Riemannian manifold, J. Funct. Anal., 1995, 134: 392-416.[5] Hsu, E., Quasi-invariance of the Wiener measure on the path space over a compact Riemannian manifold, J. Funct. Anal., 1995, 134: 417-450.[6] Lyons, T. J., Qian, Z. M., A class of vector fields on path space, J.Funct. Anal., 1997, 145: 205-223.[7] Li, X. D., Existence and uniqueness of geodesics on path spaces, J. Funct. Anal., to be published.[8] Driver, B., Towards calculus and geometry on path spaces, in Proc. Symp. Pure and Appl. Math. 57 (ed. Cranston, M., Pinsky, M.), Cornell: AMS, 1993, 1995.

  4. Geodesic flows on path spaces

    Institute of Scientific and Technical Information of China (English)

    XIANG; Kainan

    2001-01-01

    [1] Cruzeiro, A. B., Malliavin, P., Renormalized differential geometry on path spaces: Structural equation, curvature, J. Funct. Anal., 1996, 139: 119-181.[2] Stroock, D. W., Some thoughts about Riemannian structures on path spaces, preprint, 1996.[3] Driver, B., A Cameron-Martin type quasi-invariance theorem for Brownian motion on a compact manifold, J. Funct. Anal., 1992, 109: 272-376.[4] Enchev, O., Stroock, D. W., Towards a Riemannian geometry on the path space over a Riemannian manifold, J. Funct. Anal., 1995, 134: 392-416.[5] Hsu, E., Quasi-invariance of the Wiener measure on the path space over a compact Riemannian manifold, J. Funct. Anal., 1995, 134: 417-450.[6] Lyons, T. J., Qian, Z. M., A class of vector fields on path space, J.Funct. Anal., 1997, 145: 205-223.[7] Li, X. D., Existence and uniqueness of geodesics on path spaces, J. Funct. Anal., to be published.[8] Driver, B., Towards calculus and geometry on path spaces, in Proc. Symp. Pure and Appl. Math. 57 (ed. Cranston, M., Pinsky, M.), Cornell: AMS, 1993, 1995.

  5. Virus Infection

    Directory of Open Access Journals (Sweden)

    Hiroshi Abe

    2013-01-01

    Full Text Available Of 168 patients with chronic hepatitis B virus (HBV infection-related liver disease, 20 patients who had received 100 mg of lamivudine plus 10 mg/day of adefovir dipivoxil (ADV (ADV group and 124 patients who had received 0.5 mg/day of entecavir or 100 mg/day of lamivudine (non-ADV group for >1 year were enrolled. For comparative analyses, 19 well-matched pairs were obtained from the groups by propensity scores. At the time of enrollment, serum creatinine and phosphate concentrations were similar between the ADV and non-ADV groups; however, urinary phosphate ( and serum bone-specific alkaline phosphatase (BAP ( concentrations were significantly higher in the ADV group than in the non-ADV group. Serum BAP was significantly higher at the time of enrollment than before ADV administration in the ADV group (, although there was no significant change in serum BAP concentration in the non-ADV group. There was a significant positive correlation between the period of ADV therapy and ΔBAP (, . Serum BAP concentration increased before increase in serum creatinine concentration and was useful for early detection of adverse events and for developing adequate measures for continuing ADV for chronic HBV infection-related liver disease.

  6. Investigation of the pathogenesis of transplacental transmission of Aleutian mink disease parvovirus in experimentally infected mink

    DEFF Research Database (Denmark)

    Broll, S.; Alexandersen, Søren

    1996-01-01

    The transplacental transmission of Aleutian mink disease parvovirus (ADV) was studied in experimental infection of 1-year-old female non-Aleutian mink. The ADV-seronegative female mink were inoculated,vith ADV prior to mating or after the expected implantation of the embryos during pregnancy...

  7. S-phase-dependent cell cycle disturbances caused by Aleutian mink disease parvovirus

    DEFF Research Database (Denmark)

    Oleksiewicz, M.B.; Alexandersen, Søren

    1997-01-01

    We examined replication of the autonomous parovirus Aleutian mink disease parovirus (ADV) in relation to cell cycle progression of permissive Crandell feline kidney (CRFK) cells. Flow cytometric analysis showed that ADV caused a composite, binary pattern of cell cycle arrest. ADV-induced cell cyc...

  8. 17 CFR 275.203-2 - Withdrawal from investment adviser registration.

    Science.gov (United States)

    2010-04-01

    ... application). (b) Electronic filing. Once you have filed your Form ADV (17 CFR 279.1) (or any amendments to... Withdrawal from investment adviser registration. (a) Form ADV-W. You must file Form ADV-W (17 CFR 279.2) to... days after acceptance solely for the purpose of commencing a proceeding under section 203(e) of the...

  9. Magnetoelectric imaging of multiferroic heterostructures (Presentation Recording)

    Science.gov (United States)

    Ghidini, Massimo; Lesaine, Arnaud; Zhu, Bonan; Moya, Xavier; Yan, Wenjing; Crossley, Sam; Nair, Bhasi; Mansell, Rhodri; Cowburn, Russell P.; Barnes, Crispin H. W.; Kronast, Florian; Valencia, Sergio; Maccherozzi, Francesco; Dhesi, Sarnjeet S.; Mathur, Neil

    2015-09-01

    Electrical control of magnetism has been demonstrated in multiferroic compounds and ferromagnetic semiconductors, but electrical switching of a substantial net magnetization at room temperature has not been demonstrated in these materials. This goal has instead been achieved in heterostructures comprising ferromagnetic films in which electrically driven magnetic changes arise due to strain or exchange bias from ferroic substrates, or due to charge effects induced by a gate. However, previous work focused on electrical switching of an in-plane magnetization or involved the assistance of applied magnetic fields. In heterostructures made of juxtaposed ferroelectric and ferromagnetic layers, we have shown electrical control with no applied magnetic field of the perpendicular magnetization of small features [1] and of magnetic stripe domains patterns [2]. Here we investigate Ni81Fe19 films on ferroelectric substrates with and without buffer layers of Cu, whose presence precludes charge-mediated coupling. Ni81Fe19 has virtually zero magnetostriction, but sufficiently thin films show large magnetostriction, and thus, on increasing film thickness through the threshold for zero magnetostriction, we have seeked the crossover from charge- to strain-mediated coupling. We will then show that strain associated with the motion of 90°- ferroelectric domain walls in a BaTiO3 substrate, can switch the magnetization of an array of overlying single-domain Ni dots. [1] M. Ghidini, R. Pellicelli, J. L. Prieto, X. Moya, J. Soussi, J. Briscoe, S. Dunn and N. D. Mathur, Nature Communications 4 (2013) 1453. [2] M. Ghidini, F.Maccherozzi, X. Moya, L. C. Phillips, W.Yan, J. Soussi, N. Métallier, M.Vickers, , N. -J.Steinke, R. Mansell, C. H. W. Barnes, S. S. Dhesi, and N. D. Mathur, Adv. Mater.doi: 10.1002/adma.201404799 (2015).

  10. Three-dimensional cell culture of chondrocytes on modified di-phenylalanine scaffolds.

    Science.gov (United States)

    Jayawarna, V; Smith, A; Gough, J E; Ulijn, R V

    2007-06-01

    The design of self-assembled peptide-based structures for three-dimensional cell culture and tissue repair has been a key objective in biomaterials science for decades. In search of the simplest possible peptide system that can self-assemble, we discovered that combinations of di-peptides that are modified with aromatic stacking ligands could form nanometre-sized fibres when exposed to physiological conditions. For example, we demonstrated that a number of Fmoc (fluoren-9-ylmethyloxycarbonyl) modified di- and tri-peptides form highly ordered hydrogels via hydrogen-bonding and pi-pi interactions from the fluorenyl rings. These highly hydrated gels allowed for cell proliferation of chondrocytes in three dimensions [Jayawarna, Ali, Jowitt, Miller, Saiani, Gough and Ulijn (2006) Adv. Mater. 18, 611-614]. We demonstrated that fibrous architecture and physical properties of the resulting materials were dictated by the nature of the amino acid building blocks. Here, we report the self-assembly process of three di-phenylalanine analogues, Fmoc-Phe-Phe-OH, Nap (naphthalene)-Phe-Phe-OH and Cbz (benzyloxycarbonyl)-Phe-Phe-OH, to compare and contrast the self-assembly properties and cell culture conditions attributable to their protecting group difference. Fibre morphology analysis of the three structures using cryo-SEM (scanning electron microscopy) and TEM (transmission electron microscopy) suggested fibrous structures with dramatically varying fibril dimensions, depending on the aromatic ligand used. CD and FTIR (Fourier-transform IR) data confirmed beta-sheet arrangements in all three samples in the gel state. The ability of these three new hydrogels to support cell proliferation of chondrocytes was confirmed for all three materials. PMID:17511646

  11. Plasma enhanced atomic layer batch processing of aluminum doped titanium dioxide

    International Nuclear Information System (INIS)

    Among many promising high-k dielectrics, TiO2 is an interesting candidate because of its relatively high k value of over 40 and its easy integration into existing semiconductor manufacturing schemes. The most critical issues of TiO2 are its low electrical stability and its high leakage current density. However, doping TiO2 with Al has shown to yield significant improvement of layer quality on Ru electrodes [S. K. Kim et al., Adv. Mater. 20, 1429 (2008)]. In this work we investigated if atomic layer deposition (ALD) of Al doped TiO2 is feasible in a batch system. Electrical characterizations were done using common electrode materials like TiN, TaN, or W. Additionally, the effect of plasma enhanced processing in this reactor was studied. For this investigation a production batch ALD furnace has been retrofitted with a plasma source which can be used for post deposition anneals with oxygen radicals as well as for directly plasma enhanced ALD. After evaluation of several Ti precursors a deposition process for AlTiOx with excellent film thickness and composition uniformity was developed. The effects of post deposition anneals, Al2O3 interlayers between electrode and TiO2, Al doping concentration, plasma enhanced deposition and electrode material type on leakage current density are shown. An optimized AlTiOx deposition process on TaN electrodes yields to leakage current density of 5 x 10-7 A/cm2 at 2 V and k values of about 35. Thus, it could be demonstrated that a plasma enhanced batch ALD process for Al doped TiO2 is feasible with acceptable leakage current density on a standard electrode material.

  12. Defects responsible for abnormal n-type conductivity in Ag-excess doped PbTe thermoelectrics

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Byungki, E-mail: byungkiryu@keri.re.kr; Lee, Jae Ki; Lee, Ji Eun; Joo, Sung-Jae; Kim, Bong-Seo; Min, Bok-Ki; Lee, Hee-Woong; Park, Su-Dong [Thermoelectric Conversion Research Center, Korea Electrotechnology Research Institute (KERI), 642-120 Changwon (Korea, Republic of); Oh, Min-Wook [Department of Advanced Materials Engineering, Hanbat National University, 305-719 Daejeon (Korea, Republic of)

    2015-07-07

    Density functional calculations have been performed to investigate the role of Ag defects in PbTe thermoelectric materials. Ag-defects can be either donor, acceptor, or isovalent neutral defect. When Ag is heavily doped in PbTe, the neutral (Ag-Ag) dimer defect at Pb-site is formed and the environment changes to the Pb-rich/Te-poor condition. Under Pb-rich condition, the ionized Ag-interstitial defect (Ag{sub I}{sup +}) becomes the major donor. The formation energy of Ag{sub I}{sup +} is smaller than other native and Ag-related defects. Also it is found that Ag{sub I}{sup +} is an effective dopant. There is no additional impurity state near the band gap and the conduction band minimum. The charge state of Ag{sub I}{sup +} defect is maintained even when the Fermi level is located above the conduction band minimum. The diffusion constant of Ag{sub I}{sup +} is calculated based on the temperature dependent Fermi level, formation energy, and migration energy. When T > 550 K, the diffusion length of Ag within a few minutes is comparable to the grain size of the polycrystalline PbTe, implying that Ag is dissolved into PbTe and this donor defect is distributed over the whole lattice in Ag-excess doped polycrystalline PbTe. The predicted solubility of Ag{sub I}{sup +} well explains the increased electron carrier concentration and electrical conductivity reported in Ag-excess doped polycrystalline PbTe at T = 450–750 K [Pei et al., Adv. Energy Mater. 1, 291 (2011)]. In addition, we suggest that this abnormal doping behavior is also found for Au-doped PbTe.

  13. Optimization of control parameters of CdZnTe ACRT-Bridgman single crystal growth

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    . G., The modelling of heat transfer in the melt volume during crystal growth by the Stockbarger method using ACRT, J. Cryst. Growth, 1999, 207: 226-231.[14]Distanov, V. E., Kirdyashkin, A. G., The influence of accelerated crucible rotation mode on the melt temperature field in the Stockbarger technique, J. Cryst. Growth, 2001, 222: 607-614.[15]Capper, P., Gosney, J. J. G., Jones, C. L. Et al., Bridgman growth of CdxHg1-xTe using ACRT, Journal of Electronic Materials, 1986, 15: 371-376.[16]Capper, P., Bridgman growth of CdxHg1-xTe--A review, Prog. Cryst. Growth and Gharact., 1989, 19: 259-293.[17]Capper, P., A review of impurity behavior in bulk and epitaxial of Hg1-xCdxTe, J. Vac. Sci. Techonol. B, 1991, 9(3): 1667-1681.[18]Capper, P., Harris, J. E., O'Keefe, E. et al., Bridgman growth and assessment of CdTe and CdZnTe using the accelerated crucible rotation technique, Mater. Sci. Eng. B, 1993, 16(1-3): 29-39.[19]Capper, P., Harris, J. E., Okeeffe, E. S., Macrosegregation and microsegredation of Zn in Bridgman-grown CdZnTe, Adv. Mater. Opt. Electr., 1995, 5(2): 101-108.[20]Capper, P., Bulk Bridgman growth of cadmium mercury telluride for IR applications, J. Mater. Sci.-Mater. EL, 2001, 12: 423-428.[21]Jie, W., Li, Y., Liu, X., Solute redistribution during the accelerated crucible rotation Bridgman growth of Hg1-xMnxTe, J. Cryst. Growth, 1999, 205: 510-514.[22]Dixit, V. K., Rodrigues, B. V., Bhat, H. L., Growth of InSb(1-x)Bix crystals by rotatory Bridgman method and their characterization, J. Cryst. Growth, 2000, 217: 40-46.[23]Brice, J. C., Capper, P., Jones, C. L. et al., ACRT: A review of models, Prog. Crystal Growth and Gharact., 1986, 13: 197-229.[24]Liu Juncheng, Jie Wanqi, Zhou Yaohe, Experimental Study of the ACRT Ekman flow, Acta Metallurgica Sinica, 1996, 32: 269-273.[25]Liu Juncheng, Jie Wanqi, Zhou Yaohe, Numerical simulation of the convection during ACRT, Progress in Natural Science, 1997, 7(2): 215.[26

  14. Projections of Singular Vectors of Verma Modules over Rank 2 Kac-Moody Lie Algebras

    Directory of Open Access Journals (Sweden)

    Dmitry Fuchs

    2008-08-01

    Full Text Available We prove an explicit formula for a projection of singular vectors in the Verma module over a rank 2 Kac-Moody Lie algebra onto the universal enveloping algebra of the Heisenberg Lie algebra and of sl_2 (Theorem 3. The formula is derived from a more general but less explicit formula due to Feigin, Fuchs and Malikov [Funct. Anal. Appl. 20 (1986, no. 2, 103-113]. In the simpler case of A_1^1 the formula was obtained in [Fuchs D., Funct. Anal. Appl. 23 (1989, no. 2, 154-156].

  15. Isotropic bodies and Bourgain's problem

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    [1]Milman, V. D., Pajor, A., Isotropic position and inertia ellipsoid and zonoids of the unit ball of a normed ndimensional space, Geometric aspects of functional analysis (1987-1988), Lecture Notes in Math., 1989, 1376:64-104.[2]Blaschke, W., Uber affine Geometry ⅩⅣ: eine minimum Aufgabe fur Legendres tragheits Ellipsoid, Ber. verh.sachs. Akad. d. Wiss., 1918, 70: 72-75.[3]Blaschke, W., Uber affine Geometry Ⅺ: losing der "Vierpunkproblems" von Sylvester aus der Teorie der geometrischen Wahrsdeinlichkeiten, Leipziger Berichte, 1917, 69: 436-453.[4]John, F., Polar correspondence with respect to convex regions, Duke Math. J., 1937, 3(2): 355-369.[5]Lutwak, E., Yang, D., Zhang, G., A new ellipsoid associated with convex bodes, Duke. Math. J., 2000, 104:375-390.[6]Bourgain, J., On the distribution of polynomails on high dimensional convex sets, Geometric aspects of functional analysis (1989-1990), Lecture Notes in Math., 1991, 1469: 127-137.[7]Dar, S., Remarks on Bourgain's problem on slicing of convex bodies, Geomitric aspects of functional analysis,in Oper. Theory Adv. Appl., Vol, 77, Basel: Birkhauser, 1995, 61-66.[8]Ball, K., Normed spaces with a weak-Gordon-Lewis property, in: Proc. of Funct. Anal., University of Texas and Austin (1987-1989), Lecture Notes in Math., 1991, 1470: 36-47.[9]Schneider, R., Weil, W., Zonoids and related topics, in Convexity and Its Applications (eds. Gruber, P. M., Wills,J. M.), Basel: Birkhauser, 1983, 296-317.[10]Bourgain, J., Klartag, B., Milman, V., A reduction of the slicing problem to finite volume ratio bodies, Geometry/Functional Analysis, C. R. Acad. Sci. Paris, Ser. I, 2003, 336: 331-334.[11]Ren, D. L., An Introduction to Integral Geometry (in Chinese), Shanghai: Science and Technology Press, 1988.[12]Gardner, R. J., Geometric Tomography, Cambridge: Cambridge University Press, 1995.[13]Leichtweiβ, K., Affine Geometry of Convex Bodies, Heidelberg: J. A. Barth, 1998.[14]Schneider, R., Convex Bodies: The Brunn

  16. Embedding theorems of Besov and Triebel-Lizorkin spaces on spaces of homogeneous type

    Institute of Scientific and Technical Information of China (English)

    YANG; Dachun(

    2003-01-01

    , Cambridge: Cambridge Univ. Press, 1996.[15]Macias, R. A., Segovia, C., Lipschitz functions on spaces of homogeneous type, Adv. in Math., 1979, 33: 257.[16]Han, Y., Sawyer, E. T., Littlewood-Paley theory on spaces of homogeneous type and classical function spaces,Memoirs Amer. Math. Soc., 1994, 110(530): 1.[17]Han, Y., Inhomogeneous Calderón reproducing formula on spaces of homogeneous type, J. Geometric Anal.,1997, 7: 259.[18]David, G., Journé, J. L., Semmes, S., Opérateurs de Calderón-Zygmund, fonctions para-accrétives et interpolation, Rev. Mat. Iberoamericana, 1985, 1: 1.[19]Christ, M., A T(b) theorem with remarks on analytic capacity and the Cauchy integral, Colloq. Math., 1990,LX/LXI: 601.[20]Triebel, H., Theory of Function Spaces, Basel: Birkhauser Verlag, 1983.[21]Frazier, M., Jawerth, B., A discrete transform and decompositions of distribution spaces, J. Funct. Anal.,1990, 93: 34.[22]Fefferman, C., Stein, E. M., Some maximal inequalities, Amer. J. Math., 1971, 93: 107.

  17. Boundedness of a class of super singular integral operators and the associated commutators

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    [1]Calderón, A. P., Zygmund, A., On singular integrals, Amer. J. Math., 1956, 78: 89-309.[2]Fefferman, R., A note on singular integrals, Proc. Amer. Math. Soc., 1979, 74(2): 266-270.[3]Duoandikoetxea, J., Rubio de Francia, L. J., Maximal and singular integral operators via Fourier transform estimates, Invent. Math., 1986, 84(3): 541-561.[4]Dan, D. S., Pan, Y. B., Singular integral operators with rough kernel, Amer. J. Math., 1997, 119(4): 799-839.[5]Chen, J. C., Fan, D. S., Ying, Y. M., Certain operators with singular kernels, Canadian J. Math., 2003, 55(3):504-532.[6]Frazier, M., Jawerth, B., Weiss, G., Littlewood-Paley Theory and Study of Function Spaces, AMS-CBMS Regional Conf Ser, Vol. 79, Washington D C: Conf. Board Math. Sci., 1991, 41-49.[7]Coifman, R. R., Rochberg, R., Weiss, G., Factorization theorems for Hardy spaces in several variables, Ann.Math., 1976, 103(3): 611-635.[8]Duoandikoetxea, J., Weighted norm inequalities for homogeneous singular integrals, Trans. Amer. Math. Soc.,1993, 336(2): 869-880.[9]Alvarez, J., Bagby, R., Kurtz, D. et al., Weighted estimates for commutators of linear operators, Studia Math.,1993, 104(2): 195-209.[10]Hu, G., Lp boundedness for the commutator of a homogeneous singular integral operator, Studia Math., 2002,154(1): 13-27.[11]Lu, S., Wu, Q., Yang, D., Boundedness of commutators on Hardy type spaces, Sci. China Ser. A, 2002, 45(8):984-997.[12]Calderón, A. P., Commutators of singular integral operators, Proc. Nat. Acad. Sci. USA, 1965, 53: 1092-1099.[13]Hofmann, S., An off-diagonal T1 theorem and applications, J. Funct. Anal., 1998, 160(2): 581-622.[14]Colzani, L., Taibleson, M., Weiss, G., Maximal estimates for Cesaro and Riesz means on sphere, Indiana Univ.Math. J., 1984, 33(6): 873-889.[15]Stein, E. M., Harmomic Analysis: Real-Variable Methods, Orthogonality and Osillatory Integrals, Princeton,New Jersy: Princeton University Press, 1993.[16

  18. Tracking adenovirus infections in reptiles

    OpenAIRE

    Ball, Inna

    2015-01-01

    The purpose of this project was to screen reptiles for the presence of adenovirus (AdV) infection, develop serological tests for the detection of antibodies against AdVs in squamate reptiles and to examine the serological relationships between lizard and snake AdVs, helping to ensure the establishment and maintenance of healthy populations. An additional aim of the project was the establishment of an agamid cell line and isolation of adenoviruses from bearded dragons (Pogona vitticeps). A...

  19. Aleutian disease of mink: the antibody response of sapphire and pastel mink to Aleutian disease virus.

    Science.gov (United States)

    Bloom, M E; Race, R E; Hadlow, W J; Chesebro, B

    1975-10-01

    The specific antiviral antibody response of sapphire and pastel mink to Pullman strain of ADV has been examined. Sapphire mink inoculated with from 300,000-3 LD50 developed high levels of specific antibody and AD. Pastel mink inoculated with parallel doses of ADV also produced antibody but did not develop AD. The low incidence of AD in pastel mink inoculated with Pullman strain of ADV is probably related to factors other than antiviral antibody.

  20. Fatal systemic adenoviral infection superimposed on pulmonary mucormycosis in a child with acute leukemia

    Science.gov (United States)

    Seo, Yu Mi; Hwang-Bo, Seok; Kim, Seong koo; Han, Seung Beom; Chung, Nack-Gyun; Kang, Jin Han

    2016-01-01

    Abstract Background: Although adenovirus (ADV) infection usually causes self-limiting respiratory disorders in immune competent children; severe and systemic ADV infection in children undergoing chemotherapy for leukemia has been continuously reported. Nevertheless, there has been no consensus on risk factors and treatment strategies for severe ADV infection in children undergoing chemotherapy. Case summary: We report a case of a 15-year-old boy with a fatal systemic ADV infection. He had received reinduction chemotherapy for relapsed acute lymphoblastic leukemia under continuing antifungal therapy for previously diagnosed fungal pneumonia. He complained of fever and right shoulder pain 4 days after completing the reinduction chemotherapy. In spite of appropriate antibiotic and antifungal therapy, pneumonia was aggravated and gross hematuria was accompanied. A multiplex polymerase chain reaction test for respiratory viruses was positive for ADV in a blood sample, and a urine culture was positive for ADV. He received oral ribavirin, intravenous immunoglobulin, and intravenous cidofovir therapy; however, he eventually died. Relapsed leukemia, concurrent fungal pneumonia, and delayed cidofovir administration were considered the cause of the grave outcome in this patient. Conclusion: ADV may cause severe infections not only in allogeneic hematopoietic cell transplant recipients, but also in patients undergoing chemotherapy for acute leukemia. The risk factors for severe ADV infection in patients undergoing chemotherapy should be determined in the future studies, and early antiviral therapy should be administered to immune compromised patients with systemic ADV infection. PMID:27749571

  1. Prognostics Health Management for Advanced Small Modular Reactor Passive Components

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Ryan M.; Ramuhalli, Pradeep; Coble, Jamie B.; Mitchell, Mark R.; Wootan, David W.; Hirt, Evelyn H.; Berglin, Eric J.; Bond, Leonard J.; Henager, Charles H.

    2013-10-18

    In the United States, sustainable nuclear power to promote energy security is a key national energy priority. Advanced small modular reactors (AdvSMR), which are based on modularization of advanced reactor concepts using non-light-water reactor (LWR) coolants such as liquid metal, helium, or liquid salt may provide a longer-term alternative to more conventional LWR-based concepts. The economics of AdvSMRs will be impacted by the reduced economy-of-scale savings when compared to traditional LWRs and the controllable day-to-day costs of AdvSMRs are expected to be dominated by operations and maintenance costs. Therefore, achieving the full benefits of AdvSMR deployment requires a new paradigm for plant design and management. In this context, prognostic health management of passive components in AdvSMRs can play a key role in enabling the economic deployment of AdvSMRs. In this paper, the background of AdvSMRs is discussed from which requirements for PHM systems are derived. The particle filter technique is proposed as a prognostics framework for AdvSMR passive components and the suitability of the particle filter technique is illustrated by using it to forecast thermal creep degradation using a physics-of-failure model and based on a combination of types of measurements conceived for passive AdvSMR components.

  2. In-situ study of martensitic transformation and nucleation,propagation of crack in CuNiAl shape memory alloy

    Institute of Scientific and Technical Information of China (English)

    LU; Yonghao

    2001-01-01

    [1]Otsuka,K.,Kubo,H.,Wayman,C.M.,Diffuse electron scattering and “streaming” effect,Metall.Trans.A,1981,12:595-605.[2]Otsuka,K.,Wayman,C.M.,Kubo,H.,Diffuse electron scattering in β-phase alloys,Metall.Trans.A,1978,9:1075-1085.[3]Singh,J.,Chen,H.,Wayman,C.M.,Transformation sequence in a Cu-Al-Ni shape memory alloy at elevated temperatures,Metall.Trans.A,1986,17:65-72.[4]Sun,Y.S.,Lorimer,G.W.,Ridley,N.,Microstructure and its development in Cu-Al-Ni alloys,Metall.Trans.A,1990,21:575-588.[5]Miyazaki,S.,Kawai,T.,Otsuka,K.,On the origin of intergranular fracture in β phase shape memory alloys,Scripta Metall.,1982,16:431-436.[6]Otsuka,K.,Wayman,C.M.,Naka,K.et al.,Superelasticity effects and stress-induced martensitic transformations in Cu-Al-Ni alloys,Acta Metall.,1976,24:207-226.[7]Otsuka,K.,Sakamoto,H.,Shimizu,K.,Successive stress-induced martensitic transformations and associated transformation pseudoelasticity in Cu-Al-Ni alloys,Acta Metall.,1979,27:585-600.[8]Shield,T.W.,Orientation dependence of the pseudoelastic behavior of single crystal of Cu-Al-Ni in tension,J.Mech.Phys.Solids,1995,43(6):869-895.[9]Sun,Q.P.,Zhang,X.Y.,Xu,T.,Experimental study of martensitic transformation in single shape memory alloy,Adv.Solids Mech.,1997,7:155-162.[10]Chen,Q.Z.,Chu,W.Y.,Hsiao,C.M.,In-situ TEM observation of nucleation and bluntness of nanocrack in 310 stainless steel,Acta Metall.Mater.,1995,43:4371-4376.[11]Chu,W.Y.,Gao,K.W.,Wang,Y.B.et al.,Nucleating and propagation of nanocrack in dislocation free zone in brittle material,Science in China,Ser.A,1995,38(14):1501-1509.[12]Chen,Q.Z.,Gao,K.W.,Gu,B.et al.,Nucleating,blunting and propagation of A nanocrack in DFZ of thin crystals,Fatigue Frac.Eng.Mater.Stru.,1996,21:1415-1423.[13]Nishiyama,Z.,Stacking faults in the martensite of Cu-Al alloy,Journal of the Physical Society of Japan,1965,20:1192-1121.[14]Lovey,F.C.,Van Tendeloo,G.,Van Landuyt,J.et al.,HREM imaging

  3. Rapid analysis of trace pollutants using laser mass spectrometry

    Institute of Scientific and Technical Information of China (English)

    WEI; Jie

    2001-01-01

    [1]Otsuka,K.,Kubo,H.,Wayman,C.M.,Diffuse electron scattering and “streaming” effect,Metall.Trans.A,1981,12:595-605.[2]Otsuka,K.,Wayman,C.M.,Kubo,H.,Diffuse electron scattering in β-phase alloys,Metall.Trans.A,1978,9:1075-1085.[3]Singh,J.,Chen,H.,Wayman,C.M.,Transformation sequence in a Cu-Al-Ni shape memory alloy at elevated temperatures,Metall.Trans.A,1986,17:65-72.[4]Sun,Y.S.,Lorimer,G.W.,Ridley,N.,Microstructure and its development in Cu-Al-Ni alloys,Metall.Trans.A,1990,21:575-588.[5]Miyazaki,S.,Kawai,T.,Otsuka,K.,On the origin of intergranular fracture in β phase shape memory alloys,Scripta Metall.,1982,16:431-436.[6]Otsuka,K.,Wayman,C.M.,Naka,K.et al.,Superelasticity effects and stress-induced martensitic transformations in Cu-Al-Ni alloys,Acta Metall.,1976,24:207-226.[7]Otsuka,K.,Sakamoto,H.,Shimizu,K.,Successive stress-induced martensitic transformations and associated transformation pseudoelasticity in Cu-Al-Ni alloys,Acta Metall.,1979,27:585-600.[8]Shield,T.W.,Orientation dependence of the pseudoelastic behavior of single crystal of Cu-Al-Ni in tension,J.Mech.Phys.Solids,1995,43(6):869-895.[9]Sun,Q.P.,Zhang,X.Y.,Xu,T.,Experimental study of martensitic transformation in single shape memory alloy,Adv.Solids Mech.,1997,7:155-162.[10]Chen,Q.Z.,Chu,W.Y.,Hsiao,C.M.,In-situ TEM observation of nucleation and bluntness of nanocrack in 310 stainless steel,Acta Metall.Mater.,1995,43:4371-4376.[11]Chu,W.Y.,Gao,K.W.,Wang,Y.B.et al.,Nucleating and propagation of nanocrack in dislocation free zone in brittle material,Science in China,Ser.A,1995,38(14):1501-1509.[12]Chen,Q.Z.,Gao,K.W.,Gu,B.et al.,Nucleating,blunting and propagation of A nanocrack in DFZ of thin crystals,Fatigue Frac.Eng.Mater.Stru.,1996,21:1415-1423.[13]Nishiyama,Z.,Stacking faults in the martensite of Cu-Al alloy,Journal of the Physical Society of Japan,1965,20:1192-1121.[14]Lovey,F.C.,Van Tendeloo,G.,Van Landuyt,J.et al.,HREM imaging

  4. Controlling Cellular Endocytosis at the Nanoscale

    Science.gov (United States)

    Battaglia, Giuseppe

    2011-03-01

    , amphiphilic molecules, and hydrophilic molecules without affecting the viability of cells or even triggering inflammatory pathways. Finally we show how size, surface chemistry and surface topology of the vesicles affect their interaction with the cell membrane and hence their cellular uptake. References: C. Lo Presti, M. Massignani, T. Smart, H. Lomas, and G. Battaglia J. Mater. Chem. (2009) 19, 3576-3590 H. Lomas, I. Canton, S. MacNeil, J. Du, S.P. Armes, A.J. Ryan, A.L. Lewis and G. Battaglia Adv. Mater. (2007). 19, 4238-4243 M. Massignani, I. Canton, N. Patikarnmonthon, N. J. Warren, S. P. Armes, A. L. Lewis and G. Battaglia, Nature Prec., 2010, http://hdl.handle.net/10101/npre.2010.4427.1 M. Massignani, C. LoPresti, A. Blanazs, J. Madsen, S. P. Armes, A. L. Lewis and G. Battaglia Small, 2009, 5, 2424-2432. M. Massignani, T. Sun, A. Blanazs, V. Hearnden, I. Canton, P. Desphande, S. Armes, S. MacNeil, A. Lewis and G. Battaglia PLoS One, 2010, 5, e10459.

  5. Highly-efficient all-dielectric Huygens' surface holograms (Conference Presentation)

    Science.gov (United States)

    Chong, Katie; Wang, Lei; Staude, Isabelle; James, Anthony; Dominguez, Jason; Subramania, Ganapathi; Liu, Sheng; Decker, Manuel; Neshev, Dragomir N.; Brener, Igal; Kivshar, Yuri S.

    2016-04-01

    that lack dissipative losses and also suppress unwanted reflections without relying on cross-polarization schemes that additionally suffer from polarization-conversion losses. We now use such Huygens' surfaces in order to create a highly-efficient phase masks for the generation of optical holograms. By varying only one geometrical parameter, namely the lattice periodicity that can be controlled easily during the fabrication process we can effectively generate arbitrary hologram images from a 4-level phase discretization. In order to design the arrangement of the pixels in the metasurfaces, we calculate the phase mask required for a hologram generating the letters `hv' in the hologram plane. In the next step the Huygens' hologram is fabricated on a back-side polished SOI wafer by electron-beam lithography followed by a reactive-ion etching process. Then, we measure the phase of the generated hologram using a home-built Mach-Zehnder interferometer and perform a phase retrieval process to compare the experimental phase with the designed phase. Finally, we record the holographic image in the hologram plane and demonstrate that the device functionality is completely polarization insensitive with a transmission efficiency of 82%, in contrast to all the earlier works utilizing geometric phase. References [1] Yu et al., Nat. Mater. 13, 139 (2014). [2] Pfeiffer et al., Phys. Rev. Lett. 110, 197401 (2013). [3] Monticone et al., Phys. Rev. Lett. 110, 203903 (2013). [4] Decker et al., Adv. Opt. Mater. 3, 813 (2015).

  6. A elasticidade do ligamento colateral medial da articulação do cotovelo de cão não advém de elastina The elasticity of the medial collateral ligament of the canine elbow joint does not come from elastin

    Directory of Open Access Journals (Sweden)

    Paloma Souza Costa

    2008-09-01

    Full Text Available A literatura relata que ligamentos consistem de tecido conjuntivo denso, composto por água, colágeno tipos I e III, diversas proteoglicanas, pouca elastina e várias outras substâncias. Além disso, os ligamentos, quando testados in vitro com tensão longitudinal e unidirecional, apresentam um comportamento mecânico não-linear, ou seja, as fibras colágenas são alongadas aos poucos, perdendo seu padrão ondulado, até que todas estejam no limite máximo de tração e iniciem o rompimento. Portanto, no presente estudo avaliou-se a presença de fibras elásticas (elastina no ligamento colateral medial do cotovelo de cães adultos para ponderar se a elasticidade do referido ligamento deve-se à presença de fibras elásticas ou às propriedades elásticas do colágeno ou à combinação de ambas. Foram utilizadas quatro articulações, de machos e fêmeas em igual proporção, das quais foram adquiridas as amostras das porções médias dos ligamentos colaterais mediais para a rotina histológica. Os cortes foram corados pela técnica de Weigert, e não foi observada a presença de fibras elásticas, detectável por esta técnica à microscopia de luz. Concluiu-se que a elasticidade do ligamento colateral medial do cotovelo de cão deve-se, principalmente, ao padrão ondulado das fibras colágenas, devido à quantidade ínfima ou até à inexistência de fibras elásticas nesta estrutura.The literature reports that ligaments consist of connective tissue, composed by water, Type I and III collagen, several proteoglycans, some elastin and other substances. Ligaments tested in vitro with longitudinal and unidirectional tension exhibit non-linear mechanical behavior; the collagen fibers are stretched little by little, losing their undulating pattern, until reaching the maximum limit of traction and failure begins. The aim of the present study was to assess the presence of elastin in the medial collateral ligament of the elbow in adult dogs to determine whether the stretching of this ligament is due to the presence of elastic fibers, the elastic property of the collagen or the combination of both. Four joints were used from males and females in equal proportion, taking the medial collateral ligaments for the histological examination. To detect the presence of elastic fibers, sections were stained using the Weigert method. However, light microscopy revealed no elastic fibers. It was concluded that the elasticity of the canine elbow medial collateral ligament is mainly due to the undulated pattern of the collagen fibers, considering the trace amount or inexistence of elastic fibers in this structure.

  7. Nanostructured silicon via metal assisted catalyzed etch (MACE): chemistry fundamentals and pattern engineering

    Science.gov (United States)

    Toor, Fatima; Miller, Jeffrey B.; Davidson, Lauren M.; Nichols, Logan; Duan, Wenqi; Jura, Michael P.; Yim, Joanne; Forziati, Joanne; Black, Marcie R.

    2016-10-01

    There are a range of different methods to generate a nanostructured surface on silicon (Si) but the most cost effective and optically interesting is the metal assisted wet chemical etching (MACE) (Koynov et al 2006 Appl. Phys. Lett. 88 203107). MACE of Si is a controllable, room-temperature wet-chemical technique that uses a thin layer of metal to etch the surface of Si, leaving behind various nano- and micro-scale surface features or ‘black silicon’. MACE-fabricated nanowires (NWs) provide improved antireflection and light trapping functionality (Toor et al 2016 Nanoscale 8 15448-66) compared with the traditional ‘iso-texturing’ (Campbell and Green 1987 J. Appl. Phys. 62 243-9). The resulting lower reflection and improved light trapping can lead to higher short circuit currents in NW solar cells (Toor et al 2011 Appl. Phys. Lett. 99 103501). In addition, NW cells can have higher fill factors and voltages than traditionally processed cells, thus leading to increased solar cell efficiencies (Cabrera et al 2013 IEEE J. Photovolt. 3 102-7). MACE NW processing also has synergy with next generation Si solar cell designs, such as thin epitaxial-Si and passivated emitter rear contact (Toor et al 2016 Nanoscale 8 15448-66). While several companies have begun manufacturing black Si, and many more are researching these techniques, much of the work has not been published in traditional journals and is publicly available only through conference proceedings and patent publications, which makes learning the field challenging. There have been three specialized review articles published recently on certain aspects of MACE or black Si, but do not present a full review that would benefit the industry (Liu et al 2014 Energy Environ. Sci. 7 3223-63 Yusufoglu et al 2015 IEEE J. Photovolt. 5 320-8 Huang et al 2011 Adv. Mater. 23 285-308). In this feature article, we review the chemistry of MACE and explore how changing parameters in the wet etch process effects the resulting

  8. Foreword: Focus on Superconductivity in Semiconductors

    Directory of Open Access Journals (Sweden)

    Yoshihiko Takano

    2008-01-01

    Full Text Available Since the discovery of superconductivity in diamond, much attention has been given to the issue of superconductivity in semiconductors. Because diamond has a large band gap of 5.5 eV, it is called a wide-gap semiconductor. Upon heavy boron doping over 3×1020 cm−3, diamond becomes metallic and demonstrates superconductivity at temperatures below 11.4 K. This discovery implies that a semiconductor can become a superconductor upon carrier doping. Recently, superconductivity was also discovered in boron-doped silicon and SiC semiconductors. The number of superconducting semiconductors has increased. In 2008 an Fe-based superconductor was discovered in a research project on carrier doping in a LaCuSeO wide-gap semiconductor. This discovery enhanced research activities in the field of superconductivity, where many scientists place particular importance on superconductivity in semiconductors.This focus issue features a variety of topics on superconductivity in semiconductors selected from the 2nd International Workshop on Superconductivity in Diamond and Related Materials (IWSDRM2008, which was held at the National Institute for Materials Science (NIMS, Tsukuba, Japan in July 2008. The 1st workshop was held in 2005 and was published as a special issue in Science and Technology of Advanced Materials (STAM in 2006 (Takano 2006 Sci. Technol. Adv. Mater. 7 S1.The selection of papers describe many important experimental and theoretical studies on superconductivity in semiconductors. Topics on boron-doped diamond include isotope effects (Ekimov et al and the detailed structure of boron sites, and the relation between superconductivity and disorder induced by boron doping. Regarding other semiconductors, the superconducting properties of silicon and SiC (Kriener et al, Muranaka et al and Yanase et al are discussed, and In2O3 (Makise et al is presented as a new superconducting semiconductor. Iron-based superconductors are presented as a new series of high

  9. Nanostructured silicon via metal assisted catalyzed etch (MACE): chemistry fundamentals and pattern engineering.

    Science.gov (United States)

    Toor, Fatima; Miller, Jeffrey B; Davidson, Lauren M; Nichols, Logan; Duan, Wenqi; Jura, Michael P; Yim, Joanne; Forziati, Joanne; Black, Marcie R

    2016-10-14

    There are a range of different methods to generate a nanostructured surface on silicon (Si) but the most cost effective and optically interesting is the metal assisted wet chemical etching (MACE) (Koynov et al 2006 Appl. Phys. Lett. 88 203107). MACE of Si is a controllable, room-temperature wet-chemical technique that uses a thin layer of metal to etch the surface of Si, leaving behind various nano- and micro-scale surface features or 'black silicon'. MACE-fabricated nanowires (NWs) provide improved antireflection and light trapping functionality (Toor et al 2016 Nanoscale 8 15448-66) compared with the traditional 'iso-texturing' (Campbell and Green 1987 J. Appl. Phys. 62 243-9). The resulting lower reflection and improved light trapping can lead to higher short circuit currents in NW solar cells (Toor et al 2011 Appl. Phys. Lett. 99 103501). In addition, NW cells can have higher fill factors and voltages than traditionally processed cells, thus leading to increased solar cell efficiencies (Cabrera et al 2013 IEEE J. Photovolt. 3 102-7). MACE NW processing also has synergy with next generation Si solar cell designs, such as thin epitaxial-Si and passivated emitter rear contact (Toor et al 2016 Nanoscale 8 15448-66). While several companies have begun manufacturing black Si, and many more are researching these techniques, much of the work has not been published in traditional journals and is publicly available only through conference proceedings and patent publications, which makes learning the field challenging. There have been three specialized review articles published recently on certain aspects of MACE or black Si, but do not present a full review that would benefit the industry (Liu et al 2014 Energy Environ. Sci. 7 3223-63; Yusufoglu et al 2015 IEEE J. Photovolt. 5 320-8; Huang et al 2011 Adv. Mater. 23 285-308). In this feature article, we review the chemistry of MACE and explore how changing parameters in the wet etch process effects the resulting texture

  10. Bargaining for Over-The Counter Risk Redistributions : The Case of Longevity Risk

    NARCIS (Netherlands)

    Boonen, T.J.; De Waegenaere, A.M.B.; Norde, H.W.

    2012-01-01

    Abstract: Existing literature regarding the natural hedge potential that arises from combining liabilities with different sensitivities focuses on the optimal liability mix, but does not address the question whether and how changes in the liability mix can be obtained. In the absence of a well-funct

  11. 12.DIGESTIVE TRACT 12.1.Esophagus

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920110 The clinical study on gastroeso-phageal reflux.LUO Jinyan (罗金燕),et al.Digest Funct Lab,2nd Affil Hosp,Xian Med Univ.Chin J Digest 1991; 11(3): 137-140.Fifty-two patients with symptomatic gas-troesophageal reflux (GER) were studied withprolonged intraesopnageal pH monitoring,scin-

  12. Safety and clinical outcome of erythropoiesis-stimulating agents in patients with ST-elevation myocardial infarction : A meta-analysis of individual patient data

    NARCIS (Netherlands)

    Fokkema, Marieke L.; van der Meer, Peter; Rao, Sunil V.; Belonje, Anne M.; Ferrario, Maurizio; Hillege, Hans L.; Katz, Stuart D.; Lipsic, Erik; Ludman, Andrew J.; Ott, Ilka; Prunier, Fabrice; Choi, Dong-Ju; Toba, Ken; van Veldhuisen, Dirk J.; Voors, Adriaan A.

    2014-01-01

    Background Erythropoiesis-stimulating agents (ESAs) have been investigated in small studies in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Erythropoiesis-stimulating agents did not show a clear effect on left ventricular funct

  13. Origin, Impact and Cost of Interface Instability

    NARCIS (Netherlands)

    Raemaekers, S.B.A.

    2015-01-01

    Third-party libraries are used frequently in modern software development. Websites that are visited millions of times a day often make heavy use of open-source software libraries. As a software developer, using these libraries has a number of advantages. Developers save time and effort because funct

  14. Medication adherence in patients with rheumatoid arthritis: a critical appraisal of the existing literature

    NARCIS (Netherlands)

    Bemt, B.J.F. van den; Zwikker, H.E.; Ende, C.H.M. van den

    2012-01-01

    Adherence to medication in patients with rheumatoid arthritis is low, varying from 30 to 80%. Improving adherence to therapy could therefore dramatically improve the efficacy of drug therapy. Although indicators for suboptimal adherence can be useful to identify nonadherent patients, and could funct

  15. Strichartz Estimates for the Schrödinger Propagator for the Laguerre Operator

    Indian Academy of Sciences (India)

    Vijay Kumar Sohani

    2013-11-01

    We obtain homogeneous Strichartz estimate for the Schrödinger propagator $e^{-itL_}$ for the Laguerre operator $L_$ on $\\mathbb{R}^n_+$. We follow regularization technique as introduced in J. Funct. Anal. 224(2) (2005) 371–385. We also establish inhomogeneous Strichartz estimates for different admissible pairs.

  16. Soil management options to sequester carbon and mitigate the greenhouse effect

    NARCIS (Netherlands)

    Batjes, N.H.

    2000-01-01

    The imbalance between global sources and sinks in the global budget of atmospheric CO2 is one of the most important problems in the study of global change. At present there is a 'missing sink' of about 1-2 Pg C yr -1. It is likely that a major part of this sink for carbon is to be found in the funct

  17. Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition

    NARCIS (Netherlands)

    Jansen, Sepp R; Poppinga, Wilfred J; de Jager, Wim; Lezoualc'h, Frank; Cheng, Xiaodong; Wieland, Thomas; Yarwood, Stephen J; Gosens, Reinoud; Schmidt, Martina

    2016-01-01

    In epithelial cells, β-catenin is localized at cell-cell junctions where it stabilizes adherens junctions. When these junctions are disrupted, β-catenin can translocate to the nucleus where it functions as a transcriptional cofactor. Recent research has indicated that PGE2 enhances the nuclear funct

  18. Experimental verification of Lorentz' linearization procedure for quadratic friction

    NARCIS (Netherlands)

    G.M. Terra; W.J. van den Berg; L.R.M. Maas

    2005-01-01

    Abstract: We present results from laboratory experiments in a ‘tidal tank’, demonstrating the resonant response of the Helmholtz mode in an almost-enclosed basin. In particular the dependence of the response curve (amplification of the tide in the basin relative to the tidal signal at sea as a funct

  19. Ecological, Social and Economic Evaluation of Transport Scenarios: An Integral Approach. A Phd research programme

    NARCIS (Netherlands)

    Geurs KT; LAE

    2000-01-01

    This report describes a research programme for the development of a methodology for the integral assessment of ecological, economic and social impacts of transport scenarios. The following research activities are planned: (1) a literature study on theories and conceptual models, explaining the funct

  20. Isolation, Structure, and Electronic Calculations of the Heterofullerene Salt K6C59N

    NARCIS (Netherlands)

    Prassides, Kosmas; Keshavarz-K., Majid; Hummelen, Jan Cornelis; Andreoni, Wanda; Giannozzi, Paolo; Beer, Ernst; Bellavia, Cheryl; Cristofolini, Luigi; González, Rosario; Lappas, Alexandros; Murata, Yasuo; Malecki, Magdalena; Srdanov, Vojislav; Wudl, Fred

    1996-01-01

    An intercalation compound of azafullerene, K6C59N, was prepared and structurally characterized. It is isostructural with the fullerene compound K6C60, adopts a body-centered-cubic structure (lattice constant a = 11.31 angstroms), and consists of quasi-spherical monomeric (C59N)6- ions. Density funct

  1. Human hand modelling: kinematics, dynamics, applications

    NARCIS (Netherlands)

    Gustus, A.; Stillfried, G.; Visser, J.; Jörntell, H.; Van der Smagt, P.

    2012-01-01

    An overview of mathematical modelling of the human hand is given. We consider hand models from a specific background: rather than studying hands for surgical or similar goals, we target at providing a set of tools with which human grasping and manipulation capabilities can be studied, and hand funct

  2. Comparing the social costs of biofuels and fossil fuels: A case study of Vietnam

    NARCIS (Netherlands)

    Thanh, le L.; Ierland, van E.C.; Zhu, X.; Wesseler, J.H.H.; Ngo, G.

    2013-01-01

    Biofuel substitution for fossil fuels has been recommended in the literature and promoted in many countries; however, there are concerns about its economic viability. In this paper we focus on the cost-effectiveness of fuels, i.e., we compare the social costs of biofuels and fossil fuels for a funct

  3. Drawbacks of the use of indirect estimates of renal function to evaluate the effect of risk factors on renal function

    NARCIS (Netherlands)

    Verhave, JC; Gansevoort, RT; Hillege, HL; De Zeeuw, D; Curhan, GC; De Jong, PE

    2004-01-01

    Many epidemiologic studies presently aim to evaluate the effect of risk factors on renal function. As direct measurement of renal function is cumbersome to perform, epidentiologic studies generally use an indirect estimate of renal function. The consequences of using different methods of renal funct

  4. Standardization of lower secondary civic education and inequality of the civic and political engagement of students

    NARCIS (Netherlands)

    J. Witschge; H.G. van de Werfhorst

    2015-01-01

    In this paper, the relation between the standardization of civic education and the inequality of civic engagement is examined. Using data from the International Civic and Citizenship Education Study 2009 among early adolescents and Eurydice country-level data, three-level analysis and variance funct

  5. Linear operator inequalities for strongly stable weakly regular linear systems

    NARCIS (Netherlands)

    Curtain, RF

    2001-01-01

    We consider the question of the existence of solutions to certain linear operator inequalities (Lur'e equations) for strongly stable, weakly regular linear systems with generating operators A, B, C, 0. These operator inequalities are related to the spectral factorization of an associated Popov funct

  6. Neuronal stress following exposure to 56Fe particles and the effects of antioxidant-rich diets

    Science.gov (United States)

    Exposing young rats to particles of high energy and charge (HZE particles), a ground-based model for exposure to cosmic rays, enhances indices of oxidative stress and inflammation and disrupts the functioning of neuronal communication in critical regions of the brain. These changes in neuronal funct...

  7. Sequence Classification: 892754 [

    Lifescience Database Archive (English)

    Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|6323393|ref|NP_013465.1| Putative phosphoesterase that funct...ions as a dosage-dependent positive regulator of the G1/S phase transition by contr

  8. Sequencing Games with Repeated Players

    NARCIS (Netherlands)

    Estevez Fernandez, M.A.; Borm, P.E.M.; Calleja, P.; Hamers, H.J.M.

    2004-01-01

    Two classes of one machine sequencing situations are considered in which each job corresponds to exactly one player but a player may have more than one job to be processed, so called RP(repeated player) sequencing situations.In max-RP sequencing situations it is assumed that each player's cost funct

  9. Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor

    NARCIS (Netherlands)

    Alam, Mohammad Tauqeer; Takano, Eriko; Breitling, Rainer

    2011-01-01

    Background: Streptomyces coelicolor, a model organism of antibiotic producing bacteria, has one of the largest genomes of the bacterial kingdom, including 7825 predicted protein coding genes. A large number of these genes, nearly 34%, are functionally orphan (hypothetical proteins with unknown funct

  10. Autofocusing imaging: Imaging with primaries, internal multiples and free-surface multiples

    NARCIS (Netherlands)

    Singh, S.; Snieder, R.; Behura, J.; van der Neut, J.R.; Wapenaar, C.P.A.; Slob, E.C.

    2014-01-01

    Recent work on autofocusing with the Marchenko equation has shown how the Green's function for a virtual source in the subsurface can be obtained from reflection data. The response to the virtual source is the Green's function from the location of the virtual source to the surface. The Green's funct

  11. SABATH Methyltransferases from White Spruce (Picea glauca [Moench] Voss): Gene Cloning, Functional Characterization and Structural Analysis

    Science.gov (United States)

    Known members of the plant SABATH family of methyltransferases have important biological functions by methylating hormones, signaling molecules and other metabolites. While all previously characterized SABATH genes were isolated from angiosperms, in this article, we report on the isolation and funct...

  12. The Impact of Mitochondrial Complex Inhibition on mESC Differentiation

    Science.gov (United States)

    The Impact of Mitochondrial Complex Inhibition on mESC Differentiation JE Royland, SH Warren, S Jeffay, MR Hoopes, HP Nichols, ES Hunter U.S. Environmental Protection Agency, Integrated Systems Toxicology Division, Research Triangle Park, NC The importance of mitochondrial funct...

  13. Unilateral Tinnitus : Changes in Connectivity and Response Lateralization Measured with fMRI

    NARCIS (Netherlands)

    Lanting, Cornelis P.; de Kleine, Emile; Langers, Dave R. M.; van Dijk, Pim

    2014-01-01

    Tinnitus is a percept of sound that is not related to an acoustic source outside the body. For many forms of tinnitus, mechanisms in the central nervous system are believed to play a role in the pathology. In this work we specifically assessed possible neural correlates of unilateral tinnitus. Funct

  14. Manual therapy with or without physical medicine modalities for neck pain: a systematic review

    NARCIS (Netherlands)

    J. D'Sylva; J. Miller; A. Gross; S.J. Burnie; C.H. Goldsmith; N. Graham; T. Haines; G. Brønfort; J.L. Hoving

    2010-01-01

    Manual therapy interventions are often used with or without physical medicine modalities to treat neck pain. This review assessed the effect of 1) manipulation and mobilisation, 2) manipulation, mobilisation and soft tissue work, and 3) manual therapy with physical medicine modalities on pain, funct

  15. Applying footprint models to investigate MO-dissimilarity over heterogeneous areas

    NARCIS (Netherlands)

    Boer, van de A.; Graf, A.; Moene, A.F.; Schüttemeyer, D.

    2012-01-01

    Monin Obukhov Similarity Theory (MOST) is one of the cornerstones of surface layer meteorology and as such it is widely applied in models and for data analysis. One major disadvantage of using MOST for describing land-atmosphere interactions is that all turbulence properties are described as a funct

  16. Association mapping across numerous traits reveals patterns of functional variation in maize

    Science.gov (United States)

    Phenotypic variation in natural populations results from a combination of genetic effects, environmental effects, and gene-by-environment interactions. Despite the vast amount of genomic data becoming available, many pressing questions remain about the nature of genetic mutations that underlie funct...

  17. Velocity profiles in strongly turbulent Taylor-Couette flow

    NARCIS (Netherlands)

    Grossmann, S.; Lohse, D.; Sun, C.

    2014-01-01

    We derive the velocity profiles in strongly turbulent Taylor-Couette flow for the general case of independently rotating cylinders. The theory is based on the Navier-Stokes equations in the appropriate (cylinder) geometry. In particular, we derive the axial and the angular velocity profiles as funct

  18. Fluorescence relaxation spectroscopy: light on dynamical structures of flavoproteins.

    NARCIS (Netherlands)

    Burten-Bastiaens, P.I.H.

    1992-01-01

    Refinements in technique and data analysis have opened new avenues for a detailed interpretation of protein fluorescence. What is more, by combining new insights in protein structure and dynamics with improved knowledge of photophysics of biological chromophores, the coupling between structure-funct

  19. Cardiovascular risk prediction in the Netherlands

    NARCIS (Netherlands)

    Dis, van S.J.

    2011-01-01

    Background: In clinical practice, Systematic COronary Risk Evaluation (SCORE) risk prediction functions and charts are used to identify persons at high risk for cardiovascular diseases (CVD), who are considered eligible for drug treatment of elevated blood pressure and serum cholesterol. These funct

  20. CRYSTAL-STRUCTURES OF HEVAMINE, A PLANT DEFENSE PROTEIN WITH CHITINASE AND LYSOZYME ACTIVITY, AND ITS COMPLEX WITH AN INHIBITOR

    NARCIS (Netherlands)

    VANSCHELTINGA, ACT; KALK, KH; BEINTEMA, JJ; DIJKSTRA, BW

    1994-01-01

    Background: Hevamine is a member of one of several families of plant chitinases and lysozymes that are important for plant defence against pathogenic bacteria and fungi. The enzyme can hydrolyze the linear polysaccharide chains of chitin and peptidoglycan. A full understanding of the structure/funct

  1. What is a Sorting Function?

    DEFF Research Database (Denmark)

    Henglein, Fritz

    2009-01-01

    What is a sorting function—not a sorting function for a given ordering relation, but a sorting function with nothing given? Formulating four basic properties of sorting algorithms as defining requirements, we arrive at intrinsic notions of sorting and stable sorting: A function is a sorting funct...

  2. Strategies for structuring interdisciplinary education in Systems Biology: an European perspective

    NARCIS (Netherlands)

    Cvijovic, Marija; Höfer, Thomas; Acimovic, Jure; Alberghina, Lilia; Almaas, Eivind; Besozzi, Daniela; Blomberg, Anders; Bretschneider, Till; Cascante, Marta; Collin, Olivier; Atauri, de Pedro; Depner, Cornelia; Dickinson, Robert; Dobrzynski, Maciej; Fleck, C.; Garcia-Ojalvo, Jordi; Gonze, Didier; Hahn, Jens; Hess, Heide Marie; Hollmann, Susanne; Krantz, Marcus; Kummer, Ursula; Lundh, Torbjörn; Martial, Gifta; Martins dos Santos, V.A.P.; Mauer-Oberthür, Angela; Regierer, Babette; Skene, Barbara; Stalidzans, Egils; Stelling, Jörg; Teusink, Bas; Workman, Christopher T.; Hohmann, Stefan

    2016-01-01

    Systems Biology is an approach to biology and medicine that has the potential to lead to a better understanding of how biological properties emerge from the interaction of genes, proteins, molecules, cells and organisms. The approach aims at elucidating how these interactions govern biological funct

  3. New molecular targets for PET and SPECT imaging in neurodegenerative diseases

    NARCIS (Netherlands)

    Benadiba, Marcel; Luurtsema, Gert; Wichert-Ana, Lauro; Buchpigel, Carlos Alberto; Busatto Filho, Geraldo

    2012-01-01

    The pathophysiology of neurodegenerative diseases (ND) such as Alzheimer's disease (AD) and Parkinson's disease (PD) has not yet been completely elucidated. However, in the past few years, there have been great knowledge advances about intra-and extracellular proteins that may display impaired funct

  4. Sequence Classification: 525247 [

    Lifescience Database Archive (English)

    Full Text Available ion unknown, intitally thought to be hydrogenase-2 small subunit which now identified as hybO || http://www.ncbi.nlm.nih.gov/protein/62181660 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|62181660|ref|YP_218077.1| funct

  5. The role of leadership in regional climate change adaptation: a comparison of adaptation practices initiated by governmental and non-governmental actors

    NARCIS (Netherlands)

    Meijerink, S.V.; Stiller, S.J.; Carina, E.; Keskitalo, K; Scholten, P.; Smits, R; Lamoen, F van

    2015-01-01

    This paper aims to better understand the role of leadership in regional climate change adaptation. We first present a framework, which distinguishes five functions of leadership within inter-organizational networks: the connective, enabling, adaptive, political–administrative and dissemination funct

  6. Severe degeneration of peripheral motor axons after spinal cord injury: a European multicenter study in 345 patients.

    NARCIS (Netherlands)

    Meent, H. van de; Hosman, A.J.F.; Hendriks, J.; Zwarts, M.J.; Schubert, M.

    2010-01-01

    OBJECTIVE: There are indications that perilesional and remote peripheral motor axons may degenerate after spinal cord injury (SCI). The authors investigated the magnitude and dependence on severity of SCI of this degeneration as well as whether motor axons so affected can recover. METHODS: The funct

  7. Immune evasion by pseudomonal proteases

    NARCIS (Netherlands)

    Bardoel, B.W.

    2011-01-01

    The innate immune system recognizes and rapidly kills invading bacteria via different mechanisms. Bacteria exploit several strategies to evade recognition by the immune system in order to survive within the host. An important strategy of bacteria is the secretion of proteins that block crucial funct

  8. Main: 1N8Q [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available Protocatechuic Acid In Its X-Ray Structure At 2.1 A Resolution. Proteins: V. 54 13 2004 Struct., Funct., Ge..._1; 1.|PROSITE; PS00081; LIPOXYGENASE_2; 1.|PROSITE; PS50095; PLAT; 1. X-Ray Diffraction, Resolution: 2.10 A

  9. Personality disorders and social functioning in depressed patients

    NARCIS (Netherlands)

    Kool, S; Dekker, J; Duijsens, [No Value; de Jonghe, F; de Jong, P; Schouws, S

    2000-01-01

    There is a high level of comorbidity of personality disorders with major depression. Patients who suffer from both depression and an axis II disorder are, in general, more severely ill and ill for longer periods. The presence of personality disorders also has a negative influence on the social funct

  10. The Relationship Between the Positivity of Parvovirus B19-DNA and the Level of Soluble Interleukin-2 Receptors of Infected Maters%孕妇细小病毒B19-DNA阳性与血清可溶性白介素-2受体水平的关系

    Institute of Scientific and Technical Information of China (English)

    曹懿; 屈新中; 李芬

    2006-01-01

    目的:通过研究细小病毒B19(parvovirus B19,B19)感染孕妇的妊娠结局与血清可溶性白介素-2受体(sIL-2R)的关系,探讨体内的细胞免疫状态对妊娠结局的作用.方法:随访14例B19-DNA阳性孕妇的妊娠结局并检测新生儿脐血血清中的B19-DNA,比较不同妊娠结局孕妇、新生儿脐血血清中的sIL-2R.结果:①B19-DNA阳性孕妇分娩的14例新生儿中,B19-DNA阳性4例,阴性10例,宫内传播率为28.57%;②B19-DNA阳性的新生儿组血清sIL-2R为(642.32±64.51)pg/l,明显高于阴性组(379.96±56.47)pg/ml(p<0.05);③新生儿脐血B19-DNA阳性的孕妇组血清sIL-2R为(569.48±162.66)pg/ml明显高于新生儿阴性的孕妇组(363.12±86.62)pg/ml(p<0.05).结论:B19感染孕妇血清sIL-2R升高对胎儿宫内感染有一定的提示作用.B19感染孕妇体内的细胞免疫增强,不利于孕期的细胞/体液免疫平衡,可能是导致不良妊娠结局产生的原因之一.

  11. Consumo, produção de leite e estresse térmico em vacas da raça Pardo-Suíça alimentadas com castanha de caju Dry mater intake, milk yield, and heat stress indicators of dairy cows fed diets with cashew nut

    Directory of Open Access Journals (Sweden)

    P.G. Pimentel

    2007-12-01

    Full Text Available Avaliaram-se o consumo de matéria seca, a produção de leite e os indicadores de estresse térmico de vacas Pardo-Suíça alimentadas com castanha de caju no semi-árido do Nordeste do Brasil. Doze animais foram distribuídos em um ensaio de reversão, com quatro tratamentos: 0, 8, 16 e 24% de castanha no concentrado. As vacas receberam cana-de-açúcar à vontade e sete quilos de concentrado por dia. Maior consumo de matéria seca de cana-de-açúcar foi observado no tratamento com concentrado sem castanha (7,70kgMS/dia em relação aos tratamentos com 16% e 24% de castanha (7,35 e 7,05kgMS/dia, respectivamente. O consumo no tratamento com concentrado sem castanha não diferiu do consumo no tratamento com 8% (7,59kgMS/dia. Não houve efeito dos tratamentos sobre a produção de leite e sobre as variáveis indicativas de estresse térmico (P>0,05.A study was carried out to evaluate dry matter intake, milk yield, and heat stress parameters in Brown Swiss cows fed diets with cashew nut. Animals were raised in the semi-arid region of the Brazilian Northeast. Twelve cows were subjected to a switch back experimental design, with four treatments: 0, 8, 16, and 24% of cashew nut in the concentrate. Each cow received 7kg of concentrate per day and had free access to sugar cane. Dry matter (DM intake and milk yield were daily taken as well as measurements of rectal and milk temperature; and cardiac and respiratory rates. The highest intake of forage (sugar cane was obtained when the concentrate had no cashew nut (7.7kgDM/day. This value was not different when the concentrate contained 8% of cashew nut (7.59kgDM/day but greater than dry matter intake of cows receiving diets with 16% of cashew nut (7.35kgDM/day; P0.05. Such low variability in daily milk yield could be associated with the higher energy density of diets containing more cashew nut. Finally, indicators of heat stress were not influenced by changes in the diets, given the air temperatures and environment where all cows were raised.

  12. Study on Functional Design, Modular Assembly and Structure-activity Relation of Composition Photocatalytic Materals%复合光催化材料的功能设计、模块化组装及构效关系研究

    Institute of Scientific and Technical Information of China (English)

    何杰

    2016-01-01

    光催化技术是目前研究的热点课题之一,但作为光催化技术研究的核心内容-光催化材料的设计理论与功能组装等方面相对薄弱。该研究拟以材料复合功能设计为目标,模块化组装为手段,研究聚氧钛铌酸盐纳米片-过渡金属离子以及金属氧化物复合光催化剂的设计、组装与构效关系。采用高温固相、聚合-络合等方法合成了规整的层状聚氧钛铌酸盐异构体如KTiNbO5和K3Ti5NbO14等作为光催化材料的基本组元,选用合适的前驱物如硝酸盐或羰基制备对有机硫化物具有吸附作用的吸附模块如Ni2+、Fe3+等离子和NiO和Fe2O3等氧化物,研究模块构建与协同组装技术,构建复合功能光催化材料;以硫醇/硫醚为探针反应物,研究复合光催化材料中有机物富集与光催化氧化功能的耦合。通过XRD、TEM、LRS、UV-vis DRS和FT-IR等表征技术对复合光催化材料的结构、光化学特征以及催化作用进行表征;并探讨了反应机理。结果表明,随着纳米片单元中Ti/Nb的变化,光谱响应特征出现明显的规律,层间过渡金属离子与价带电子轨道发生明显的相互作用改变了带隙能量。氧化物柱撑中前驱物直接影响材料的结构与组元之间的相互作用,并进而影响材料的性能。%Photocatalytic technology is one of the hot topics in current research. However, the theoretical design and functional assembly of the photocatlytic materials are relatively weaker. The purpose of this study is to design composite functional materials using modular assembly technology, as the functional design theory, modular assembly technology and structure-activity relationship of the layered polyoxo-titanoniobate and cation or oxide nano-crystals of transition metal were researched systematically. The layered polyoxo-titanoniobates such as KTiNbO5, and K3Ti5NbO14 etc, as basic modular, which were prepared by polymerization complex method or solid state reaction method. The adsorption modular that adsorbed the organic sulfides, such as Ni2+ and Fe3+ ions, and NiO and Fe2O3, which were prepared by decomposition of its nitrate or carbonyl complexes. The composite functional photocatalytic materials were built by the modular building and colaborative assembly technology. The adsorption and photocatalytic activity was evaluated using ethyl mercaptan/dimethyl sulfide as the probe molecule. X-ray diffraction (XRD), Transmission electron microscopy (TEM), UV-vis diffuse reflectance spectroscopy (UV-vis DRS), and Fourier transform infrared spectroscopy (FT-IR) etc were used to characterize the structure feature and photochemical properties of these composites, and the reaction mechanism also was suggested. The results show that the characteristics of spectral response appear regularity changes with the changes of Ti/Nb of the nanosheet unit. The significant interaction between the transition metal ions of interlayer and the valence band orbital changes the band gap energies, and the preparation method of oxide pilared precursors directly affected the interaction between material structure and the modular units, and further influence the photocatalytic properties of materials.

  13. Degradabilidade in situ da silagem de quatro genótipos de sorgo com e sem tanino: I - Matéria seca e proteína bruta In situ degradability of four sorgum silages with or without tannin: I - Dry mater and crude protein

    Directory of Open Access Journals (Sweden)

    W.E. Campos

    2003-04-01

    Full Text Available Avaliaram-se a degradabilidade in situ da matéria seca (MS e da proteína bruta (PB da silagem de quatro genótipos de sorgo, dois com tanino (CMS XS 210 e BR 701 e dois sem tanino (CMS XS 214 e BR007 em um delineamento de blocos inteiramente ao acaso, com três repetições (animais, em arranjo de parcelas subdivididas. Os genótipos constituíram as parcelas e os tempos de digestão as subparcelas. O genótipo CMS XS 210 apresentou menor degradabilidade da MS em relação aos demais e os genótipos que continham tanino (CMS XS 210 e BR 701 apresentaram menores degradabilidades da PB em relação aos que não o continham.The in situ procedure was used to evaluate the disappearance of dry matter (DM and crude protein (CP of four sorghum genotypes with (CMS XS 210 and BR 701 or without (CMS XS 214 and BR 007 tannin in a completely randomized block design experiment with three replicates (animals, in a split plot arrangement. The four genotypes were allotted to the plots and the time of disappearance to the split plot. The DM of CMS XS210 was less degraded when compared to the others and sorghums with tannin showed lower CP degradability when compared to the sorghums without tannin.

  14. Degradação da matéria seca e da proteína bruta de silagens de milho sem espigas com cana -de-açúcar e bagaço de mandioca = Dry mater and crude protein ruminal degradation of corn silage without spikes with sugar cane and manioc pulp

    OpenAIRE

    Marcos Elias Traad da Silva; Nina Waszczynskyj; Carlos Ricardo Soccol; Paulo Rossi Junior; Leandro Cavalcante Lipinski

    2006-01-01

    A degradação ruminal da matéria seca (MS) e da proteína bruta (PB) de silagen s de milho sem espigas (SMSE) com cana -de-açúcar (CA) e bagaço seco de mandioca (BSM), comparadas com a silagem de milho com espigas (SMCE), foi avaliada. A ensilagem foi feita com (CI) e sem inoculante (SI) - Lactobacillus plantarum e L paracasei ssp. paracasei. Estudaram-se: as frações solúvel (A), potencialmente degradável (B) e não degradável (C); a taxa de degradação da fração B (c); a degradabilidade efetiva ...

  15. Degradação da matéria seca e da proteína bruta de silagens de milho sem espigas com cana -de-açúcar e bagaço de mandioca = Dry mater and crude protein ruminal degradation of corn silage without spikes with sugar cane and manioc pulp

    Directory of Open Access Journals (Sweden)

    Marcos Elias Traad da Silva

    2006-10-01

    Full Text Available A degradação ruminal da matéria seca (MS e da proteína bruta (PB de silagen s de milho sem espigas (SMSE com cana -de-açúcar (CA e bagaço seco de mandioca (BSM, comparadas com a silagem de milho com espigas (SMCE, foi avaliada. A ensilagem foi feita com (CI e sem inoculante (SI - Lactobacillus plantarum e L paracasei ssp. paracasei. Estudaram-se: as frações solúvel (A, potencialmente degradável (B e não degradável (C; a taxa de degradação da fração B (c; a degradabilidade efetiva (DE e potencial (DP, para ostratamentos: T1 (SMSE+20% CA -SI; T2 (SMSE+20% CA -CI; T3 (SMSE+35% CASI; T4 (SMSE+35% CA-CI; T5 (SMSE+20% BSM-SI; T6 (SMSE+20% BSM-CI; T7 (SMSE+35% BSM-SI; T8 (SMSE+35% BSM-CI; T9 (SMCE-SI e T10 (SMCE-CI. As médias foram comparadas num delineamento inteiramente casualisado. Houve diferença (P0,05. A adição de BSM (20 e 35% às SMSE aumentou (PThe goal of this work was to evaluate the ruminal degradation of corn silages without spikes (CSWS, added with sugar cane (SC and dry manioc pulp (DMP, as compared as corn silage (CS. The foods were ensiled with (WI and without (IF inoculant’s, composed by Lactobacillus plantarum and L. paracasei ssp. paracasei. The following fractions have been studied: water soluble (A, potentiallydegradable (B, non degradable (C, fraction B degradable ratio (c; effective (ED and potential (PD degradability. The treatments evaluated were: T1 (CSWS + 20% SC -IF; T2 (CSWS + 20% SC-WI; T3 (CSWS + 35% SC -IF; T4 (CSWS + 35% SC -WI; T5 (CSWS + 20% DMP-IF; T6 (CSWS + 20% DMP -WI; T7 (CSWS + 35% DMP -IF; T8 (CSWS + 35% DMP-WI; T9 (CS-WI and T10 (CS-IF. The average differences havebeen compared on a completely randomized model. Difference (P 0.05 for all treatments. Dry manioc pulp added to the non spikes cornsilage (20 and 35% - DM basis, has allowed the rise of the DM fraction B, indicating the possibility to add up to 35% of dry manioc pulp on corn silage, inst ead of green spikes.

  16. Consumo, produção de leite e estresse térmico em vacas da raça Pardo-Suíça alimentadas com castanha de caju Dry mater intake, milk yield, and heat stress indicators of dairy cows fed diets with cashew nut

    OpenAIRE

    P.G. Pimentel; A.A.A.N. Moura; J.N.M Neiva; Araújo, A. A.; R.F.L. Tair

    2007-01-01

    Avaliaram-se o consumo de matéria seca, a produção de leite e os indicadores de estresse térmico de vacas Pardo-Suíça alimentadas com castanha de caju no semi-árido do Nordeste do Brasil. Doze animais foram distribuídos em um ensaio de reversão, com quatro tratamentos: 0, 8, 16 e 24% de castanha no concentrado. As vacas receberam cana-de-açúcar à vontade e sete quilos de concentrado por dia. Maior consumo de matéria seca de cana-de-açúcar foi observado no tratamento com concentrado sem castan...

  17. Degradabilidade in situ da silagem de quatro genótipos de sorgo com e sem tanino: I - Matéria seca e proteína bruta In situ degradability of four sorgum silages with or without tannin: I - Dry mater and crude protein

    OpenAIRE

    W.E. Campos; H.M. Saturnino; B.M. Sousa; I. Borges; L.C. Gonçalves; Ferreira, P. M.; A.U. Carvalho

    2003-01-01

    Avaliaram-se a degradabilidade in situ da matéria seca (MS) e da proteína bruta (PB) da silagem de quatro genótipos de sorgo, dois com tanino (CMS XS 210 e BR 701) e dois sem tanino (CMS XS 214 e BR007) em um delineamento de blocos inteiramente ao acaso, com três repetições (animais), em arranjo de parcelas subdivididas. Os genótipos constituíram as parcelas e os tempos de digestão as subparcelas. O genótipo CMS XS 210 apresentou menor degradabilidade da MS em relação aos demais e os genótipo...

  18. 通过富集母血浆中胎儿游离 DNA无创性产前诊断β地中海贫血%Noninvasive prenatal diagnosis ofβ-thalassemia by enriching cell-free fetal DNA in materal plasma

    Institute of Scientific and Technical Information of China (English)

    王青青; 张媛; 章钧; 郝秀兰; 侯红瑛

    2014-01-01

    AIM:To establish a kind of simple and efficient method for cell-free fetal DNA ( cff-DNA) enrich-ment and to investigate its range of applications and the advantages and disadvantages.METHODS:(1) The single nucleo-tide polymorphisms( SNPs) , which linked to paternalβ-thalassemia mutations, were screened.We analyzed the contact be-tween the SNPs inβ-thalassemia gene ( HBB gene) and haploid type by the Haploview software, and then selected these close SNPs which have higher heterozygosity with the HBB gene.(2) We selected 4 cases of different β-thalassemia muta-tions with their husband, and then we used TT-FAST-COLD-PCR to enrich the IVS-II-654 mutations in maternal plasma.If the IVS-II-654 mutation was not detected, we detected the SNP which linked to the IVS-II-654 mutation.Similarly, we used TT-FULL-COLD-PCR to enrich the CD41-42 mutations in the maternal plasma.At the same time, we used the conventional PCR to enrich CD41-42 mutation and IVS-II-654 mutation in the maternal plasma.RESULTS:(1) Nine cases of the SNP ( rs7480526) linked to the mutation at IVS-II-654 in HBB gene, and 11 cases of the SNP ( rs10768683) linked to the muta-tion at CD41-42 in HBB gene were detected.( 2 ) We detected 1 case who inherited the paternal β-thalassemia mutation (IVS-II-654).We did not directly detect patermal IVS-II-654 mutation in maternal plasma, but detected the SNP linked to the IVS-II-654 mutation in the other case and had 100%detection, and 2 cases inherited the paternal β-thalassemia muta-tions (CD41-42) in the maternal plasma by TT-FULL-COLD-PCR and had 100%detection.However, we detected nothing by conventional PCR.CONCLUSION:TT-COLD-PCR is applicable to enrich cell-free fetal DNA in maternal plasma and is a method in the field of noninvasive prenatal diagnosis.%目的:评价富集母血浆中胎儿游离DNA的实验平台在母血浆中富集、鉴定胎儿游离DNA的适用范围。方法:(1)筛选与父源性β地中海贫血基因连锁的单核苷酸多态性( SNP)位点:利用Haploview软件对20例β地中海贫血患者(其中CD41-42型11例,IVS-II-654型9例)的β地中海贫血基因( HBB基因)进行SNP与单倍型自动化分析,检索出HBB基因内杂合度较高的SNP位点并检测与CD41-42位点及IVS-II-654位点连锁的SNP位点。(2)选取4例孕妇外周血标本,且夫妇双方为不同的β地中海贫血基因类型,利用快速耐受温度-低变性温度共扩增PCR技术( TT-FAST-COLD-PCR)检测父源性β地中海贫血基因类型为IVS-II-654型的孕妇外周血标本,若未直接检测到IVS-II-654位点,则检测仅与IVS-II-654位点连锁的SNP位点;同样的原理,利用完全耐受温度-低变性温度共扩增技术( TT-FULL-COLD-PCR)检测父源性β地中海贫血基因类型为CD41-42型的孕妇外周血标本;同时利用普通PCR技术对上述标本进行检测。结果:(1)检测出IVS-II654位点与rs7480526位点连锁9例;CD41-42位点与rs10768683位点连锁11例;(2)通过TT-FAST-COLD-PCR技术在孕妇外周血中检测出1例父源性致病突变基因( IVS-II-654位点),另外1例未直接检测到父源性致病突变基因,但检测到与其连锁的SNP位点( rs7480526位点),与羊水细胞培养检测结果一致,检出率为100%(2/2);通过TT-FULL-COLD-PCR技术在孕妇外周血中检测出2例父源性致病突变基因(CD41-42位点),与羊水细胞培养检测结果一致,检出率为100%(2/2);而普通PCR技术均未检测到上述父源性致病突变基因及与父源性等位基因连锁的SNP位点。结论:TT-COLD-PCR技术适用于富集母血浆中胎儿游离DNA突变,可用于无创性产前诊断单基因遗传病。

  19. Passive transfer of antiviral antibodies restricts replication of Aleutian mink disease parvovirus in vivo

    DEFF Research Database (Denmark)

    Alexandersen, Søren; Larsen, S; Cohn, A.;

    1989-01-01

    When mink kits were infected neonatally with a highly virulent strain of Aleutian disease virus (ADV), 100% of both Aleutian and non-Aleutian genotype mink died of interstitial pneumonia characterized by permissive ADV infection of alveolar type II cells. Treatment of infected kits with either mi...

  20. Acute interstitial pneumonia in mink kits inoculated with defined isolates of Aleutian mink disease parvovirus

    DEFF Research Database (Denmark)

    Alexandersen, Søren; Larsen, S; Aasted, B;

    1994-01-01

    The present study addressed the causal role of Aleutian mink disease parvovirus (ADV) in acute interstitial pneumonia in mink kits. All the examined isolates of ADV caused interstitial pneumonia in newborn kits, although the severity of disease and the mortality varied. These findings indicate...

  1. Complete genome sequence and integrated protein localization and interaction map for alfalfa dwarf virus, which combines properties of both cytoplasmic and nuclear plant rhabdoviruses

    Energy Technology Data Exchange (ETDEWEB)

    Bejerman, Nicolás, E-mail: n.bejerman@uq.edu.au [Instituto de Patología Vegetal (IPAVE), Centro de Investigaciones Agropecuarias (CIAP), Instituto Nacional de Tecnología Agropecuaria INTA, Camino a 60 Cuadras k 5,5, Córdoba X5020ICA (Argentina); Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, QLD 4072 (Australia); Giolitti, Fabián; Breuil, Soledad de; Trucco, Verónica; Nome, Claudia; Lenardon, Sergio [Instituto de Patología Vegetal (IPAVE), Centro de Investigaciones Agropecuarias (CIAP), Instituto Nacional de Tecnología Agropecuaria INTA, Camino a 60 Cuadras k 5,5, Córdoba X5020ICA (Argentina); Dietzgen, Ralf G. [Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, QLD 4072 (Australia)

    2015-09-15

    Summary: We have determined the full-length 14,491-nucleotide genome sequence of a new plant rhabdovirus, alfalfa dwarf virus (ADV). Seven open reading frames (ORFs) were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, in the order 3′-N-P-P3-M-G-P6-L-5′. The ORFs are separated by conserved intergenic regions and the genome coding region is flanked by complementary 3′ leader and 5′ trailer sequences. Phylogenetic analysis of the nucleoprotein amino acid sequence indicated that this alfalfa-infecting rhabdovirus is related to viruses in the genus Cytorhabdovirus. When transiently expressed as GFP fusions in Nicotiana benthamiana leaves, most ADV proteins accumulated in the cell periphery, but unexpectedly P protein was localized exclusively in the nucleus. ADV P protein was shown to have a homotypic, and heterotypic nuclear interactions with N, P3 and M proteins by bimolecular fluorescence complementation. ADV appears unique in that it combines properties of both cytoplasmic and nuclear plant rhabdoviruses. - Highlights: • The complete genome of alfalfa dwarf virus is obtained. • An integrated localization and interaction map for ADV is determined. • ADV has a genome sequence similarity and evolutionary links with cytorhabdoviruses. • ADV protein localization and interaction data show an association with the nucleus. • ADV combines properties of both cytoplasmic and nuclear plant rhabdoviruses.

  2. Effects of Levels of Automation for Advanced Small Modular Reactors: Impacts on Performance, Workload, and Situation Awareness

    Energy Technology Data Exchange (ETDEWEB)

    Johanna Oxstrand; Katya Le Blanc

    2014-07-01

    The Human-Automation Collaboration (HAC) research effort is a part of the Department of Energy (DOE) sponsored Advanced Small Modular Reactor (AdvSMR) program conducted at Idaho National Laboratory (INL). The DOE AdvSMR program focuses on plant design and management, reduction of capital costs as well as plant operations and maintenance costs (O&M), and factory production costs benefits.

  3. Investigations on fungal parasites of marine algae in India: An appraisal

    Digital Repository Service at National Institute of Oceanography (India)

    Raghukumar, C.; Raghukumar, S.

    stream_size 12 stream_content_type text/plain stream_name Recent_Adv_Phycol_1994_39.pdf.txt stream_source_info Recent_Adv_Phycol_1994_39.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  4. Molecular characterization, phylogeny analysis and pathogenicity of a Muscovy duck adenovirus strain isolated in China in 2014

    Science.gov (United States)

    This study aimed to characterize a novel adenovirus (AdV) isolated from diseased Muscovy ducks in China. After the AdV was successfully propagated in duck embryo fibroblasts, the morphological and physicochemical properties of the virions were studied by electron microscopy and different tests. The ...

  5. Adenovirus 36 and Obesity: An Overview

    Directory of Open Access Journals (Sweden)

    Eleonora Ponterio

    2015-07-01

    Full Text Available There is an epidemic of obesity starting about 1980 in both developed and undeveloped countries definitely associated with multiple etiologies. About 670 million people worldwide are obese. The incidence of obesity has increased in all age groups, including children. Obesity causes numerous diseases and the interaction between genetic, metabolic, social, cultural and environmental factors are possible cofactors for the development of obesity. Evidence emerging over the last 20 years supports the hypothesis that viral infections may be associated with obesity in animals and humans. The most widely studied infectious agent possibly linked to obesity is adenovirus 36 (Adv36. Adv36 causes obesity in animals. In humans, Adv36 associates with obesity both in adults and children and the prevalence of Adv36 increases in relation to the body mass index. In vivo and in vitro studies have shown that the viral E4orf1 protein (early region 4 open reading frame 1, Adv mediates the Adv36 effect including its adipogenic potential. The Adv36 infection should therefore be considered as a possible risk factor for obesity and could be a potential new therapeutic target in addition to an original way to understand the worldwide rise of the epidemic of obesity. Here, the data indicating a possible link between viral infection and obesity with a particular emphasis to the Adv36 will be reviewed.

  6. Word order variation and foregrounding of complement clauses

    DEFF Research Database (Denmark)

    Christensen, Tanya Karoli; Jensen, Torben Juel

    2015-01-01

    Through mixed models analyses of complement clauses in a corpus of spoken Danish we examine the role of sentence adverbials in relation to a word order distinction in Scandinavian signalled by the relative position of sentence adverbials and finite verb (V>Adv vs. Adv>V). The type of sentence...

  7. Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance

    Institute of Scientific and Technical Information of China (English)

    Yeon Seok Seo; Ji Hoon Kim; Jong Eun Yeon; Jong-Jae Park; Jae Seon Kim; Kwan Soo Byun; Young-Tae Bak; Chang Hong Lee

    2007-01-01

    AIM: To compare the antiviral efficacy of adefovir (ADV) in lamivudine (LMV)-resistant patients with LMV treatment in nucleoside-na(i)ve patients, using serum samples collected sequentially during the course of treatment progressing from LMV to ADV.METHODS: Forty-four patients with chronic hepatitis B (CHB) were included. The patients were initially treated with LMV and then switched to ADV when LMV resistance developed. Antiviral efficacy was assessed by measuring the following: reduction in serum HBV DNA from baseline, HBV DNA negative conversion (defined as HBV DNA being undectable by the hybridization assay),and HBV DNA response (either HBV DNA level ≤ 105 copies/mL or a ≥ 2 log10 reduction from baseline HBV DNA level).RESULTS: After two and six months of treatment, HBV DNA reduction was greater with LMV compared to ADV treatment (P = 0.021). HBV DNA negative conversion rates were 64% and 27% after one month of LMV and ADV treatment respectively (P = 0.001). Similarly, HBV DNA response rates were 74% and 51% after two months of LMV and ADV treatment respectively (P = 0.026).The time taken to HBV DNA negative conversion and to HBV DNA response were both delayed in ADV treatment compared with LMV.CONCLUSION: The antiviral efficacy of ADV in LMV-resistant patients is slower and less potent than that with LMV in nucleoside-na(i)ve patients during the early course of treatment.

  8. Deep sequencing analysis of HBV genotype shift and correlation with antiviral efficiency during adefovir dipivoxil therapy.

    Directory of Open Access Journals (Sweden)

    Yuwei Wang

    Full Text Available Viral genotype shift in chronic hepatitis B (CHB patients during antiviral therapy has been reported, but the underlying mechanism remains elusive.38 CHB patients treated with ADV for one year were selected for studying genotype shift by both deep sequencing and Sanger sequencing method.Sanger sequencing method found that 7.9% patients showed mixed genotype before ADV therapy. In contrast, all 38 patients showed mixed genotype before ADV treatment by deep sequencing. 95.5% mixed genotype rate was also obtained from additional 200 treatment-naïve CHB patients. Of the 13 patients with genotype shift, the fraction of the minor genotype in 5 patients (38% increased gradually during the course of ADV treatment. Furthermore, responses to ADV and HBeAg seroconversion were associated with the high rate of genotype shift, suggesting drug and immune pressure may be key factors to induce genotype shift. Interestingly, patients with genotype C had a significantly higher rate of genotype shift than genotype B. In genotype shift group, ADV treatment induced a marked enhancement of genotype B ratio accompanied by a reduction of genotype C ratio, suggesting genotype C may be more sensitive to ADV than genotype B. Moreover, patients with dominant genotype C may have a better therapeutic effect. Finally, genotype shifts was correlated with clinical improvement in terms of ALT.Our findings provided a rational explanation for genotype shift among ADV-treated CHB patients. The genotype and genotype shift might be associated with antiviral efficiency.

  9. A novel adenovirus of Western lowland gorillas (Gorilla gorilla gorilla

    Directory of Open Access Journals (Sweden)

    Ludwig Carsten

    2010-11-01

    Full Text Available Abstract Adenoviruses (AdV broadly infect vertebrate hosts including a variety of primates. We identified a novel AdV in the feces of captive gorillas by isolation in cell culture, electron microscopy and PCR. From the supernatants of infected cultures we amplified DNA polymerase (DPOL, preterminal protein (pTP and hexon gene sequences with generic pan primate AdV PCR assays. The sequences in-between were amplified by long-distance PCRs of 2 - 10 kb length, resulting in a final sequence of 15.6 kb. Phylogenetic analysis placed the novel gorilla AdV into a cluster of primate AdVs belonging to the species Human adenovirus B (HAdV-B. Depending on the analyzed gene, its position within the cluster was variable. To further elucidate its origin, feces samples of wild gorillas were analyzed. AdV hexon sequences were detected which are indicative for three distinct and novel gorilla HAdV-B viruses, among them a virus nearly identical to the novel AdV isolated from captive gorillas. This shows that the discovered virus is a member of a group of HAdV-B viruses that naturally infect gorillas. The mixed phylogenetic clusters of gorilla, chimpanzee, bonobo and human AdVs within the HAdV-B species indicate that host switches may have been a component of the evolution of human and non-human primate HAdV-B viruses.

  10. 78 FR 48526 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-08-08

    ... based on the SLP's level of quoting and the average daily volume (``ADV'') of liquidity added by the SLP in assigned securities, excluding early closing days for the ADV calculation. \\3\\ The SLP program provides incentives for quoting and adds competition to the existing group of liquidity providers. An...

  11. The impact of developmental activities on the coastal environment and ecology in Goa - Case study

    Digital Repository Service at National Institute of Oceanography (India)

    Sawkar, K.

    stream_size 11 stream_content_type text/plain stream_name Adv_Int_Trg_Prog_CMEPP-98_1998_10pp.pdf.txt stream_source_info Adv_Int_Trg_Prog_CMEPP-98_1998_10pp.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO...

  12. Relevance of topography and sediment in ship wreck exploration - Examples from Goa waters

    Digital Repository Service at National Institute of Oceanography (India)

    Pathak, M.C.; Hashimi, N.H.; Nigam, R.

    stream_size 6 stream_content_type text/plain stream_name Recent_Adv_Mar_Archaeol_1991_135.pdf.txt stream_source_info Recent_Adv_Mar_Archaeol_1991_135.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  13. Topography and surface sediment distribution around Amee shoal Mormugao

    Digital Repository Service at National Institute of Oceanography (India)

    Ambre, N.V.

    stream_size 3 stream_content_type text/plain stream_name Recent_Adv_Mar_Archaeol_1991_113.pdf.txt stream_source_info Recent_Adv_Mar_Archaeol_1991_113.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  14. Consequences of sea level rise due to greenhouse effect for coastal archaeological monuments

    Digital Repository Service at National Institute of Oceanography (India)

    Nigam, R.; Pathak, M.C.; Hashimi, N.H.

    stream_size 6 stream_content_type text/plain stream_name Recent_Adv_Mar_Archaeol_1991_116.pdf.txt stream_source_info Recent_Adv_Mar_Archaeol_1991_116.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  15. Marine archaeological surveys off Tranquebar Tamilnadu coast - preliminary results

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, T.C.S.; Rao, K.M.

    stream_size 3 stream_content_type text/plain stream_name Recent_Adv_Mar_Archaeol_1991_127.pdf.txt stream_source_info Recent_Adv_Mar_Archaeol_1991_127.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  16. Complete genome sequence and integrated protein localization and interaction map for alfalfa dwarf virus, which combines properties of both cytoplasmic and nuclear plant rhabdoviruses

    International Nuclear Information System (INIS)

    Summary: We have determined the full-length 14,491-nucleotide genome sequence of a new plant rhabdovirus, alfalfa dwarf virus (ADV). Seven open reading frames (ORFs) were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, in the order 3′-N-P-P3-M-G-P6-L-5′. The ORFs are separated by conserved intergenic regions and the genome coding region is flanked by complementary 3′ leader and 5′ trailer sequences. Phylogenetic analysis of the nucleoprotein amino acid sequence indicated that this alfalfa-infecting rhabdovirus is related to viruses in the genus Cytorhabdovirus. When transiently expressed as GFP fusions in Nicotiana benthamiana leaves, most ADV proteins accumulated in the cell periphery, but unexpectedly P protein was localized exclusively in the nucleus. ADV P protein was shown to have a homotypic, and heterotypic nuclear interactions with N, P3 and M proteins by bimolecular fluorescence complementation. ADV appears unique in that it combines properties of both cytoplasmic and nuclear plant rhabdoviruses. - Highlights: • The complete genome of alfalfa dwarf virus is obtained. • An integrated localization and interaction map for ADV is determined. • ADV has a genome sequence similarity and evolutionary links with cytorhabdoviruses. • ADV protein localization and interaction data show an association with the nucleus. • ADV combines properties of both cytoplasmic and nuclear plant rhabdoviruses

  17. Adenovirus vectors lacking virus-associated RNA expression enhance shRNA activity to suppress hepatitis C virus replication

    Science.gov (United States)

    Pei, Zheng; Shi, Guoli; Kondo, Saki; Ito, Masahiko; Maekawa, Aya; Suzuki, Mariko; Saito, Izumu; Suzuki, Tetsuro; Kanegae, Yumi

    2013-12-01

    First-generation adenovirus vectors (FG AdVs) expressing short-hairpin RNA (shRNA) effectively downregulate the expressions of target genes. However, this vector, in fact, expresses not only the transgene product, but also virus-associated RNAs (VA RNAs) that disturb cellular RNAi machinery. We have established a production method for VA-deleted AdVs lacking expression of VA RNAs. Here, we showed that the highest shRNA activity was obtained when the shRNA was inserted not at the popularly used E1 site, but at the E4 site. We then compared the activities of shRNAs against hepatitis C virus (HCV) expressed from VA-deleted AdVs or conventional AdVs. The VA-deleted AdVs inhibited HCV production much more efficiently. Therefore, VA-deleted AdVs were more effective than the currently used AdVs for shRNA downregulation, probably because of the lack of competition between VA RNAs and the shRNAs. These VA-deleted AdVs might enable more effective gene therapies for chronic hepatitis C.

  18. Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy

    Institute of Scientific and Technical Information of China (English)

    Xing-guo ZHANG; Jing MIAO; Min-wei LI; Sai-ping JIANG; Fu-qiang HU; Yong-zhong DU

    2008-01-01

    Herein, solid lipid nanoparticles (SLN) were proposed as a new drug delivery system for adefovir dipivoxil (ADV). The octadecylamine-fluorescein isothiocynate (ODA-FITC) was synthesized and used as a fluorescence maker to be incorporated into SLN to investigate the time-dependent cellular uptake of SLN by HepG2.2.15. The SLN of monostearin with ODA-FITC or ADV were prepared by solvent diffusion method in an aqueous system. About 15wt% drug entrapment efficiency (EE) and 3wt% drug loading (DL) could be reached in SLN loading ADV. Comparing with free ADV, the inhibitory effects of ADV loaded in SLN on hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA levels in vitro were significantly enhanced.

  19. Draft Function Allocation Framework and Preliminary Technical Basis for Advanced SMR Concepts of Operations

    Energy Technology Data Exchange (ETDEWEB)

    Jacques Hugo; John Forester; David Gertman; Jeffrey Joe; Heather Medema; Julius Persensky; April Whaley

    2013-08-01

    This report presents preliminary research results from the investigation into the development of new models and guidance for Concepts of Operations in advanced small modular reactor (AdvSMR) designs. AdvSMRs are nuclear power plants (NPPs), but unlike conventional large NPPs that are constructed on site, AdvSMRs systems and components will be fabricated in a factory and then assembled on site. AdvSMRs will also use advanced digital instrumentation and control systems, and make greater use of automation. Some AdvSMR designs also propose to be operated in a multi-unit configuration with a single central control room as a way to be more cost-competitive with existing NPPs. These differences from conventional NPPs not only pose technical and operational challenges, but they will undoubtedly also have regulatory compliance implications, especially with respect to staffing requirements and safety standards.

  20. Passive transfer of antiviral antibodies restricts replication of Aleutian mink disease parvovirus in vivo

    DEFF Research Database (Denmark)

    Alexandersen, Søren; Larsen, S; Cohn, A.;

    1989-01-01

    anti-ADV gamma globulin or mouse monoclonal antibodies against ADV structural proteins reduced mortality by 50 to 75% and drastically reduced the severity of clinical signs. Interestingly, mink kits that survived the acute pulmonary disease all developed the chronic form of immune complex......When mink kits were infected neonatally with a highly virulent strain of Aleutian disease virus (ADV), 100% of both Aleutian and non-Aleutian genotype mink died of interstitial pneumonia characterized by permissive ADV infection of alveolar type II cells. Treatment of infected kits with either mink......-mediated Aleutian disease. Thus, the antibodies directed against ADV structural proteins were capable of modulating the in vivo pathogenicity from an acute fulminant disease to a chronic immune complex-mediated disorder. The mechanism of this modulation was examined by strand-specific in situ hybridization. We...

  1. Adenovirus-36 is associated with obesity in children and adults in Sweden as determined by rapid ELISA.

    Directory of Open Access Journals (Sweden)

    Malin Almgren

    Full Text Available BACKGROUND: Experimental and natural human adenovirus-36 (Adv36 infection of multiple animal species results in obesity through increasing adipogenesis and lipid accumulation in adipocytes. Presence of Adv36 antibodies detected by serum neutralization assay has previously been associated with obesity in children and adults living in the USA, South Korea and Italy, whereas no association with adult obesity was detected in Belgium/The Netherlands nor among USA military personnel. Adv36 infection has also been shown to reduce blood lipid levels, increase glucose uptake by adipose tissue and skeletal muscle biopsies, and to associate with improved glycemic control in non-diabetic individuals. PRINCIPAL FINDINGS: Using a novel ELISA, 1946 clinically well-characterized individuals including 424 children and 1522 non-diabetic adults, and 89 anonymous blood donors, residing in central Sweden representing the population in Stockholm area, were studied for the presence of antibodies against Adv36 in serum. The prevalence of Adv36 positivity in lean individuals increased from ∼7% in 1992-1998 to 15-20% in 2002-2009, which paralleled the increase in obesity prevalence. We found that Adv36-positive serology was associated with pediatric obesity and with severe obesity in females compared to lean and overweight/mildly obese individuals, with a 1.5 to 2-fold Adv36 positivity increase in cases. Moreover, Adv36 positivity was less common among females and males on antilipid pharmacological treatment or with high blood triglyceride level. Insulin sensitivity, measured as lower HOMA-IR, showed a higher point estimate in Adv36-positive obese females and males, although it was not statistically significant (p = 0.08. CONCLUSION: Using a novel ELISA we show that Adv36 infection is associated with pediatric obesity, severe obesity in adult females and lower risk of high blood lipid levels in non-diabetic Swedish individuals.

  2. 75 FR 51823 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2010-08-23

    ... protein (EGFP) gene downstream of the promoter. Excision of the EGFP gene by Cre recombinase allows... mouse model, designated 1\\glo\\, which permits conditional, gene-specific overexpression of TGF- 1. The... Human Recombinant MATER Protein Description of Technology: The inventors have identified MATER, a...

  3. Dural mast cell degranulation is a putative mechanism for headache induced by PACAP-38

    DEFF Research Database (Denmark)

    Baun, Michael; Pedersen, Martin Holst Friborg; Olesen, Jes;

    2012-01-01

    not VIP cause degranulation of mast cells in peritoneum and in dura mater. METHODS: The degranulatory effects of PACAP-38, PACAP-27 and VIP were investigated by measuring the amount of N-acetyl-β-hexosaminidase released from isolated peritoneal mast cells and from dura mater attached to the skull of...

  4. Components of Adenovirus Genome Packaging

    Science.gov (United States)

    Ahi, Yadvinder S.; Mittal, Suresh K.

    2016-01-01

    Adenoviruses (AdVs) are icosahedral viruses with double-stranded DNA (dsDNA) genomes. Genome packaging in AdV is thought to be similar to that seen in dsDNA containing icosahedral bacteriophages and herpesviruses. Specific recognition of the AdV genome is mediated by a packaging domain located close to the left end of the viral genome and is mediated by the viral packaging machinery. Our understanding of the role of various components of the viral packaging machinery in AdV genome packaging has greatly advanced in recent years. Characterization of empty capsids assembled in the absence of one or more components involved in packaging, identification of the unique vertex, and demonstration of the role of IVa2, the putative packaging ATPase, in genome packaging have provided compelling evidence that AdVs follow a sequential assembly pathway. This review provides a detailed discussion on the functions of the various viral and cellular factors involved in AdV genome packaging. We conclude by briefly discussing the roles of the empty capsids, assembly intermediates, scaffolding proteins, portal vertex and DNA encapsidating enzymes in AdV assembly and packaging. PMID:27721809

  5. Low-Dose Adefovir-Induced Hypophosphatemic Osteomalacia on Whole-Body Bone Scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Hoon; Won, Kyoung Sook; Song, Bongil; Jo, Il; Zeon, Seok Kil [Keimyung Univ., Daegu (Korea, Republic of)

    2013-12-15

    While adefovir dipivoxil (ADV) effectively suppresses the hepatitis B virus, it can cause proximal renal tubular dysfunction leading to phosphate wasting. The safety of low-dose ADV (a dose of 10 mg/day), which does not induce clinically significant nephrotoxicity, is well recognized, but a few cases of hypophosphatemic osteomalacia (HO) caused by low-dose ADV therapy have recently been reported. Although HO induced by low-dose ADV therapy is rare, the presence of bone pain in patients treated with ADV should be monitored. Bone scintigraphy can be performed to confirm the occurrence of osteomalacia and to determine the disease extent. Bone scintigraphic and radiological image findings with a brief review of the literature are presented in this article. We report two cases of HO induced by low-dose ADV therapy that showed multifocal increased radiotracer uptakes in the bilateral bony ribs, spines, pelvic bones and lower extremities on whole-body bone scintigraphy. Bone pain gradually improved after phosphate supplementation and by changing the antiviral agent. Whole-body bone scintigraphy is a highly sensitive imaging tool and can show disease extent at once in the setting of the wide range of the clinical spectrum with nonspecific radiological findings. Furthermore, frequent involvement of the lower extremities, as a result of maximum weight bearing, could be an additional scintigraphic clue for the diagnosis of HO. These cases could be helpful for both clinicians prescribing ADV and nuclear physicians to prevent delayed diagnosis and plan further appropriate treatment.

  6. Acoustic Droplet Vaporization in Biology and Medicine

    Directory of Open Access Journals (Sweden)

    Chung-Yin Lin

    2013-01-01

    Full Text Available This paper reviews the literature regarding the use of acoustic droplet vaporization (ADV in clinical applications of imaging, embolic therapy, and therapeutic delivery. ADV is a physical process in which the pressure waves of ultrasound induce a phase transition that causes superheated liquid nanodroplets to form gas bubbles. The bubbles provide ultrasonic imaging contrast and other functions. ADV of perfluoropentane was used extensively in imaging for preclinical trials in the 1990s, but its use declined rapidly with the advent of other imaging agents. In the last decade, ADV was proposed and explored for embolic occlusion therapy, drug delivery, aberration correction, and high intensity focused ultrasound (HIFU sensitization. Vessel occlusion via ADV has been explored in rodents and dogs and may be approaching clinical use. ADV for drug delivery is still in preclinical stages with initial applications to treat tumors in mice. Other techniques are still in preclinical studies but have potential for clinical use in specialty applications. Overall, ADV has a bright future in clinical application because the small size of nanodroplets greatly reduces the rate of clearance compared to larger contrast agent bubbles and yet provides the advantages of ultrasonographic contrast, acoustic cavitation, and nontoxicity of conventional perfluorocarbon contrast agent bubbles.

  7. Enfermedad neurologica por adenovirus Neurologic disease due to adenovirus infection

    Directory of Open Access Journals (Sweden)

    Cristina L. Lema

    2005-06-01

    Full Text Available El objetivo de este trabajo fue determinar la prevalencia de adenovirus (ADV en las infecciones del sistema nervioso central (SNC. Se analizaron 108 muestras de líquido cefalorraquídeo (LCR provenientes de 79 casos de encefalitis, 7 meningitis y 22 de otras patologías neurológicas, recibidas en el período 2000-2002. Cuarenta y nueve (47.35% se obtuvieron de pacientes inmunocomprometidos. La presencia de ADV se investigó mediante reacción en cadena de la polimerasa en formato anidado (Nested-PCR. La identificación del genogrupo se realizó mediante análisis filogenético de la secuencia nucleotídica parcial de la región que codifica para la proteína del hexón. Se detectó la presencia de ADV en 6 de 108 (5.5% muestras de LCR analizadas. Todos los casos positivos pertenecieron a pacientes con encefalitis que fueron 79, (6/79, 7.6%. No se observó diferencia estadísticamente significativa entre los casos de infección por ADV en pacientes inmunocomprometidos e inmunocompetentes (p>0.05. Las cepas de ADV detectadas se agruparon en los genogrupos B1 y C. En conclusión, nuestros resultados describen el rol de los ADV en las infecciones neurológicas en Argentina. La información presentada contribuye al conocimiento de su epidemiología, en particular en casos de encefalitis.The aim of this study was to assess the prevalence of adenovirusm (ADV infections in neurological disorders. A total of 108 cerebrospinal fluid (CSF samples from 79 encephalitis cases, 7 meningitis and 22 other neurological diseases analysed in our laboratory between 2000 and 2002 were studied. Forty nine (47.4% belonged to immunocompromised patients. Viral genome was detected using nested polymerase chain reaction (Nested-PCR and ADV genotypes were identified using partial gene sequence analysis of hexon gene. Adenovirus were detected in 6 of 108 (5.5% CSF samples tested. All of these were from encephalitis cases, 6/79, representing 7.6% of them. No statistically

  8. Adenoviruses in Côte d`Ivoire: investigation of diversity and interspecies transmission

    OpenAIRE

    Pauly, Maude

    2015-01-01

    Sub-Saharan Africa is considered to be a hotspot for emerging infectious diseases (EID) and the majority of these EID in humans originated from animal hosts and many are caused by viruses. In this first study on Adenovirus (AdV) in humans and domestic animals in Côte d`Ivoire, not only the prevalence and diversity of AdV shedding was assessed, but also the zoonotic and recombination potential of AdV was elucidated. The study region is situated next to the Taï National Park, the largest tropic...

  9. SYNERGISTIC EFFICACY OF ADENOVIRUS-MEDIATED BCL-XS GENE TRANSFER AND TOPOTECAN IN OVARIAN CANCER CELL

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To observe the synergistic efficacy between Adenovirus-mediated bcl-Xs(Adv-bcl-Xs) gene transfer and chemotherapy on ovarian cancer cell growth. Methods: NuTu-19 cells were infected by different titers of Adv-bcl-Xs and treated with topotecan in the meantime. Cell proliferation was measured 3 days later by MTT. Graphical representations and statistical analyses for their interaction in tumor cells were done. Results: The statistical result and Graphical representations of the statistical modeling showed synergy effect on cell growth inhibition (P<0.01). Conclusion: There were synergistic efficacies between Adv-bcl-Xs gene therapy and Topotecan in ovarian cancer cell growth.

  10. Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment

    Institute of Scientific and Technical Information of China (English)

    Soon Young Ko; Byung Kook Kim; So Young Kwon; Kyun-Hwan Kim; Jeong Han Kim; Won Hyeok Choe; Chang HongLee

    2012-01-01

    AIM:To identify hepatitis B virus polymerase gene mutations during antiviral therapy using lamivudineadefovir sequential monotherapy followed by lamivudine-adefovir combination therapy.METHODS:The patient cohort included four adult chronic hepatitis B patients who had undergone sequential monotherapy,first with lamivudine (LMV)and then,after developing viral breakthrough,with adefovir (ADV) therapy.All of the patients had non-response or viral breakthrough after LMV-ADV sequential monotherapy,which resulted in the switching of their antiviral regimen to LMV-ADV combination therapy.Eleven serum samples from the four patients who showed non-response to rescue LMV-ADV combination therapy were collected sequentially at a time before the antiviral treatment and then during the LMV monotherapy,ADV monotherapy,and LMV-ADV combination therapy.For the genotypic analysis,the whole 1310-bp polymerase gene region was amplified,cloned and sequenced.RESULTS:All patients had been previously treated with 100 mg of LMV once daily for a 15-to 26-mo period.The emergence of resistance mutations to LMV,such as rtM204V/I and/or rtL180M,were found in all patients.Their antiviral regimens were switched to ADV monotherapy as the second line treatment.All patients had viral breakthrough or non-response after the LMV-ADV sequential monotherapy.ADV-resistant mutations were detected after 13 to 19 mo of LMV-ADV sequential monotherapy.The rtA181V/T mutations were predominantly identified during the ADV treatment in the LMV-resistant patients.Twenty-seven of 38 clones were combined with an amino acid change at rt181;three clones had mutations in rt236 and one clone had a combined mutation.The rtA181V/T mutations were not suppressed by the LMV-ADV combination therapy.Thirty-nine of 64 clones showed an rtA181V/T mutation and six clones showed combined mutations in rt181 and rt236.Mutations in rt204 re-emerged during the combination treatment.The rt181 and rt204 mutations did not co-exist in one

  11. КОРПОРАТИВНО УПРАВЛЕНИЕ НА ФИНАНСОВИ ПОСРЕДНИЦИ: КОНВЕРГЕНЦИЯ И ДИВЕРГЕНЦИЯ

    OpenAIRE

    Nedelchev, Miroslav

    2012-01-01

    The paper reviews the Corporate Governance from his evolution point of view. The used perspective is a discussion between convergence and divergence in corporate governance of financial intermediaries. The discussion is core for researches in scientific and implementation papers for last fifty years. Based on “principal-agent” model the paper illustrates both the dynamics of corporate governance and contemporary points of view for convergence and divergence of systems and practices. The funct...

  12. Do Improvements in Balance Relate to Improvements in Long-Distance Walking Function after Stroke?

    OpenAIRE

    Awad, Louis N.; Reisman, Darcy S.; Binder-Macleod, Stuart A.

    2014-01-01

    Stroke survivors identify a reduced capacity to walk farther distances as a factor limiting their engagement at home and in community. Previous observational studies have shown that measures of balance ability and balance self-efficacy are strong predictors of long-distance walking function after stroke. Consequently, recommendations to target balance during rehabilitation have been put forth. The purpose of this study was to determine if the changes in balance and long-distance walking funct...

  13. The command team experimental test-bed stage 1: design and build of a submarine command room simulator

    OpenAIRE

    Roberts, A; Stanton, N A; Fay, D

    2015-01-01

    The command room system has developed across a century of submarine operations and so reflects a high state of evolution, but that does not mean that the system cannot be improved upon. Technological advances have resulted in the retrospective fitting of upgrades which may not have maximized the potential improvements offered. Future challenges for command teams in almost every domain include increasing amounts of data coupled with more automated systems and reduced manning. To optimise funct...

  14. Role of Extracellular Vesicles and microRNAs on Dysfunctional Angiogenesis during Preeclamptic Pregnancies

    OpenAIRE

    Escudero, Carlos A.; Herlitz, Kurt; Troncoso, Felipe; Acurio, Jesenia; Aguayo, Claudio; Roberts, James M.; Truong, Grace; Duncombe, Gregory; Rice, Gregory; Salomon, Carlos

    2016-01-01

    Preeclampsia is a syndrome characterized by hypertension during pregnancy, which is a leading cause of morbidity and mortality in both mother and newborn in developing countries. Some advances have increased the understanding of pathophysiology of this disease. For example, reduced utero-placental blood flow associated with impaired trophoblast invasion may lead to a hypoxic placenta that releases harmful materials into the maternal and feto-placental circulation and impairs endothelial funct...

  15. The cumulative effect of smoking at age 50, 60, and 70 on functional ability at age 75

    DEFF Research Database (Denmark)

    Støvring, Nina; Avlund, Kirsten; Schultz-Larsen, Kirsten;

    2004-01-01

    AIMS: As elderly people form a steadily growing part of the population in most parts of the world we are in need of knowledge of the influence of modifiable lifestyle factors on functional ability late in life. This study aims to examine the cumulative impact of smoking from age 50 to 70 on funct...... birthday it is possible to gain a healthier old age by abstaining from smoking....

  16. Genetic programming theory and practice XII

    CERN Document Server

    Riolo, Rick; Kotanchek, Mark

    2015-01-01

    These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics in this volume include: gene expression regulation, novel genetic models for glaucoma, inheritable epigenetics, combinators in genetic programming, sequential symbolic regression, system dynamics, sliding window symbolic regression, large feature problems, alignment in the error space, HUMIE winners, Boolean multiplexer funct

  17. PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s

    OpenAIRE

    Corona, Juan Carlos; Duchen, Michael R.

    2014-01-01

    The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was initially identified through its role in the regulation of glucose and lipid metabolism and cell differentiation. It also influences the expression or activity of a number of genes in a variety of signalling networks. These include regulation of redox balance, fatty acid oxidation, immune responses and mitochondrial funct...

  18. Energy Aware Reliable Routing Protocol (EARRP) for Mobile AdHoc Networks Using Bee Foraging Behavior and Ant Colony Optimization

    OpenAIRE

    K. G. Santhiya; Arumugam, N.

    2012-01-01

    Energy aware reliable routing in mobile ad hoc networks is an astonishing task and in this paper we propose to design, develop such protocol which will be a good solution. For developing such protocol EARRP, two swarm intelligence techniques are involved namely ant colony optimization and bee colony foraging behavior. For optimization, we proposed adaptive solutions in order to estimate MAC overhead, link eminence and residual energy. After estimating the above said metrics, the fitness funct...

  19. The Complexity of Generalized Satisfiability for Linear Temporal Logic

    OpenAIRE

    Bauland, Michael; Schneider, Thomas; Schnoor, Henning; Schnoor, Ilka; Vollmer, Heribert

    2008-01-01

    In a seminal paper from 1985, Sistla and Clarke showed that satisfiability for Linear Temporal Logic (LTL) is either NP-complete or PSPACE-complete, depending on the set of temporal operators used. If, in contrast, the set of propositional operators is restricted, the complexity may decrease. This paper undertakes a systematic study of satisfiability for LTL formulae over restricted sets of propositional and temporal operators. Since every propositional operator corresponds to a Boolean funct...

  20. Compression analysis as a tool for technical characterization and classification of pharmaceutical powders

    OpenAIRE

    Nordström, Josefina

    2008-01-01

    There are today strong incentives for an increased understanding of material properties and manufacturing processes to facilitate the development of new technologies in the pharmaceutical industry. The purpose of this thesis was to suggest methods requiring a low sample amount for characterization of technical properties of powders. Compression analysis was used to evaluate the formulation relevance of some compression equations. Using the mechanics of single granules to estimate powder funct...

  1. Continuous variable teleportation as a generalized thermalizing quantum channel

    OpenAIRE

    Ban, Masashi; Sasaki, Masahide; Takeoka, Masahiro

    2002-01-01

    A quantum channel is derived for continuous variable teleportation which is performed by means of an arbitrary entangled state and the standard protocol. When a Gaussian entangled state such as a two-mode squeezed-vacuum state is used, the continuous variable teleportation is equivalent to the thermalizing quantum channel. Continuous variable dense coding is also considered. Both the continuous variable teleportation and the continuous variable dense coding are characterized by the same funct...

  2. BLAP-Tags, TUBEs and DUB-Chips: Combined Novel Technologies will Advance Molecular Epithelial Physiology

    OpenAIRE

    Hamilton, Kirk L.

    2012-01-01

    The field of ubiquitylation and deubiquitylation of proteins in molecular physiology is growing at a rapid rate. Our understanding of molecular physiology of these processes may become limited by the advancement of technologies that scientists can employ. Therefore, it is important to approach physiological questions of ubiquitylation and deubiquitylation of proteins from a multiple methodological direction. Indeed, the role of ubiquitylation and deubiquitylation of proteins in cellular funct...

  3. Osteoconductive phosphoserine-modified poly(ε-lysine) dendrons: synthesis, titanium oxide surface functionalization and response of osteoblast-like cell lines

    OpenAIRE

    Meikle, S. T.; Bianchi, G.; Olivier, G; Santin, M.

    2013-01-01

    The lack of direct bonding between the surface of an implant and the mineralized bony tissue is among the main causes of aseptic loosening in titanium-based implants. Surface etching and ceramic coatings have led to improved osteointegration, but their clinical performance is still limited either by partial bonding or by coating delamination. In this work, a solid-phase synthesis method has been optimized to produce poly(ε-lysine) dendrons, the outermost branching generation of which is funct...

  4. A Parsing Mode based Method for Malformed SIP Messages Testing for IMS Network

    OpenAIRE

    Yulong Wang; Dong Wang; Lei Wang

    2013-01-01

    IMS(IP Multimedia Subsystem) network uses SIP (Session Initiation Protocol) as its core control protocol. The defensive ability of the malformed SIP message is particularly important for IMS network security. In this paper, we propose a malformed SIP generation method based on SIP parsing mode and the associated attack testing method. Based on SIP parsing mode of functional entities in IMS, we generate effective malformed SIP messages, which then be used to perform attacking test to IMS funct...

  5. Energy use and carbon footprint from lawn management : A case study in the Uppsala region of Sweden

    OpenAIRE

    Wesström, Therese

    2015-01-01

    Atmospheric concentrations of greenhouse gas emissions are now higher than ever before, with severe implications for both humans and ecosystems around the world. To mitigate climate change, large and sustained reductions of greenhouse gas emissions are required. The management of lawns entail frequent maintenance activities, such as mowing, irrigation and fertilisation, which require energy and cause greenhouse gas emissions. Lawns cover a significant part of urban areas worldwide, with funct...

  6. Subunit interactions and protein stability in the cyanobacterial light-harvesting proteins.

    OpenAIRE

    Plank, T; Toole, C; Anderson, L K

    1995-01-01

    Strain 4R is a phycocyanin-minus mutant of the unicellular cyanobacterium Synechocystis sp. strain 6803. Although it lacks the light-harvesting protein phycocyanin, 4R has normal levels of phycocyanin (cpc) transcripts. Sequence analysis of the cpcB gene encoding the phycocyanin beta subunit shows an insertion mutation in 4R that causes early termination of translation. Other work has shown that the phycocyanin alpha subunit and the linker proteins encoded on the cpc transcripts are all funct...

  7. Cognitive, behavioral, and autonomic correlates of mind wandering and perseverative cognition in major depression

    OpenAIRE

    Cristina eOttaviani; Leila eShahabi; Mika eTarvainen; Ian eCook; Michelle eAbrams; David eShapiro

    2015-01-01

    Autonomic dysregulation has been hypothesized to play a role in the relationships between psychopathology and cardiovascular risk. An important transdiagnostic factor that has been associated with autonomic dysfunction is perseverative cognition (PC), mainly present in Major Depressive Disorder (MDD) in the form of rumination. As the ability to adaptively let our mind wander (MW) without ruminating is critical to mental health, this study aimed to examine the autonomic concomitants of funct...

  8. A cucurbit androecy gene reveals how unisexual flowers develop and dioecy emerges

    OpenAIRE

    Boualem, Adnane; Troadec, Christelle; Camps, Céline; Lemhemdi, Afef; Morin, Halima; Sari, Marie-Agnès; Fraenkel-Zagouri, Rina; Kovalski, Irina; Dogimont, Catherine; Perl-Treves, Rafael

    2015-01-01

    Understanding the evolution of sex determination in plants requires identifying the mechanisms underlying the transition from monoecious plants, where male and female flowers coexist, to unisexual individuals found in dioecious species. We show that in melon and cucumber, the androecy gene controls female flower development and encodes a limiting enzyme of ethylene biosynthesis, ACS11. ACS11 is expressed in phloem cells connected to flowers programmed to become female, and ACS11 loss-of-funct...

  9. Altitudinal differences in flower traits and reproductive allocation

    OpenAIRE

    Fabbro, Thomas; Körner, Christian

    2005-01-01

    We tested whether alpine plants increase their effort to attract pollinators to compensate for assumed pollinator scarcity at high altitude. A three times larger fraction of the shoot was allocated to flowers in alpine plants (30 species, 2700m asl) compared to lowland plants (20 species, 600m asl), while leaf mass fraction did not differ between the altitudes. At high elevation, a three times smaller fraction of the shoot was allocated to stems, which was accompanied by a change in its funct...

  10. Molecular determinants of regulatory T cell development: the essential roles of epigenetic changes

    OpenAIRE

    Yohko eKitagawa; Naganari eOhkura; Shimon eSakaguchi

    2013-01-01

    Regulatory T (Treg) cells constitute a distinct T cell subset, which plays a key role in immune tolerance and homeostasis. The transcription factor Foxp3 controls a substantial part of Treg cell development and function. Yet its expression alone is insufficient for conferring developmental and functional characteristics of Treg cells. There is accumulating evidence that concurrent induction of Treg-specific epigenetic changes and Foxp3 expression is crucial for lineage specification and funct...

  11. Synaptic remodeling generates synchronous oscillations in the degenerated outer mouse retina

    OpenAIRE

    Wadood eHaq; Blanca eArango-Gonzalez; Eberhart eZrenner; Thomas eEuler; Timm eSchubert

    2014-01-01

    During neuronal degenerative diseases, neuronal microcircuits undergo severe structural alterations, leading to remodeling of synaptic connectivity. The functional consequences of such remodeling are mostly unknown. For instance, in mutant rd1 mouse retina, a common model for Retinitis Pigmentosa, rod bipolar cells (RBCs) establish contacts with remnant cone photoreceptors (cones) as a consequence of rod photoreceptor cell death and the resulting lack of presynaptic input. To assess the funct...

  12. Assessment of Peripheral Lung Mechanics

    OpenAIRE

    Bates, Jason H. T.; Suki, Béla

    2008-01-01

    The mechanical properties of the lung periphery are major determinants of overall lung function, and can change dramatically in disease. In this review we examine the various experimental techniques that have provided data pertaining to the mechanical properties of the lung periphery, together with the mathematical models that have been used to interpret these data. These models seek to make a clear distinction between the central and peripheral compartments of the lung by encapsulating funct...

  13. Automated Techniques for Hash Function and Block Cipher Cryptanalysis (Automatische technieken voor hashfunctie- en blokcijfercryptanalyse)

    OpenAIRE

    Mouha, Nicky

    2012-01-01

    Cryptography is the study of mathematical techniques that ensure the confidentiality and integrity of information. This relatively new field started out as classified military technology, but has now become commonplace in our daily lives. Cryptography is not only used in banking cards, secure websites and electronic signatures, but also in public transport cards, car keys and garage door openers.Two building blocks in the domain of cryptography are block ciphers and (cryptographic) hash funct...

  14. Tunnelling in organic superconductors

    OpenAIRE

    Bolech, C. J.; Giamarchi, T.

    2005-01-01

    We discuss the possibility of deciding on the symmetry of the superconducting phase in the organic superconductors (Bechgaard salts), using tunnelling experiments. We first briefly review the properties of organic superconductors, and the possibility to have unconventional (triplet) superconductivity in these systems. We then present a simple scheme for computing the full current-voltage characteristics for tunnelling experiments within the framework of the non-equilibrium Keldysh Green funct...

  15. Temperature-dependent alterations in metabolic enzymes and proteins of three ecophysiologically different species of earthworms

    OpenAIRE

    Tripathi, G.; N. Kachhwaha; I. Dabi; N. Bandooni

    2011-01-01

    The effects of varying temperatures (12 - 44° C) on the specific activity of cytoplasmic malate dehydrogenase ((cMDH), mitochondrial malate dehydrogenase (mMDH) and lactate dehydrogenase (LDH) of some earthworms (Metaphire posthuma, Perionyx sansibaricus and Lampito mauritii) were studied. The effects of different temperatures on supernatant and mitochondrial protein contents were also investigated. The specific activities of cMDH, mMDH and LDH of the earthworms decreased gradually as a funct...

  16. Subpixel Image Registration by Estimating the Polyphase Decomposition of the Cross Power Spectrum

    OpenAIRE

    Shekarforoush, Hassan; Berthod, Marc; Zerubia, Josiane

    1995-01-01

    A method of registering images at subpixel accuracy has been propos ed, which does not resort to interpolation. The method is based on the phase co rrelation method and is remarkably robust to correlated noise and uniform varia tions of luminance. We have shown that the cross power spectrum of two images, containing subpixel shifts, is a polyphase decomposition of a Dirac delta funct ion. By estimating the sum of polyphase components one can then determine subpi xel shifts along each axis.

  17. Protein target discovery of drug and its reactive intermediate metabolite by using proteomic strategy

    OpenAIRE

    Lianghai Hu; John Paul Fawcett; Jingkai Gu

    2012-01-01

    Identifying protein targets of bioactive compounds is an effective approach to discover unknown protein functions, identify molecular mechanisms of drug action, and obtain information for optimization of lead compounds. At the same time, metabolic activation of a drug can lead to cytotoxicities. Therefore, it is very important to systemically characterize the drug and its reactive intermediate. Mass spectrometry-based proteomic approach has emerged as the most efficient to study protein funct...

  18. The effect-enhancing and toxicity-reducing activity of Hypericum japonicum Thunb. extract in murine liver cancer chemotherapy

    OpenAIRE

    ZHANG, HONG-BO; Lu, Ping; CAO, WEN-BO; Zhang, Zhen-Hua; MENG, XIANG-LEI

    2012-01-01

    Chinese herbs are potential sources of antitumor drugs with immunoregulatory activity and few adverse effects. In the present study, we investigated whether the Hypericum japonicum Thunb. (HJT) extract enhanced the efficacy of 5-fluorouracil (5-FU) treatment in murine liver tumor xenografts and reduced toxicity of chemotherapy in hepatoma H22-bearing mice. Tumor weight and inhibition rate, thymus and spleen indices, as well as white blood cell (WBC) count were calculated. The phagocytic funct...

  19. Third Order Trace Formula

    Indian Academy of Sciences (India)

    Arup Chattopadhyay; Kalyan B Sinha

    2013-11-01

    In J. Funct. Anal. 257 (2009) 1092–1132, Dykema and Skripka showed the existence of higher order spectral shift functions when the unperturbed self-adjoint operator is bounded and the perturbation is Hilbert–Schmidt. In this article, we give a different proof for the existence of spectral shift function for the third order when the unperturbed operator is self-adjoint (bounded or unbounded, but bounded below).

  20. Flipped parameter technique applied on source localization in energy constraint sensor arrays

    OpenAIRE

    Pavlović Vlastimir D.; Veličković Zoran S.

    2009-01-01

    In this paper novel flipped parameter technique (FPT) for time delay estimation (TDE) in source localization problem is described. We propose passive source localization technique based on the development of an energy efficient algorithm that can reduce intersensor and interarray communication. We propose a flipped parameter (FP) which can be defined for any sensor in distributed sensor subarrays during the observation period. Unlike classical TDE methods that evaluate cross-correlation funct...

  1. α-Synuclein and Mitochondria: Partners in Crime?

    OpenAIRE

    Nakamura, Ken

    2013-01-01

    Increased α-synuclein levels and mutations in mitochondria-associated proteins both cause familial Parkinson’s disease (PD), and synuclein and mitochondria also play central, but poorly understood, roles in the pathogenesis of idiopathic PD. A fraction of synuclein interacts with mitochondria, and synuclein can produce mitochondrial fragmentation and impair mitochondrial complex I activity. However, the consequences of these mitochondrial changes for bioenergetic and other mitochondrial funct...

  2. Yeast surface display for protein engineering and characterization

    OpenAIRE

    Gai, S. Annie; Wittrup, K. Dane

    2007-01-01

    Yeast surface display is being employed to engineer desirable properties into proteins for a broad variety of applications. Labeling with soluble ligands enables rapid and quantitative analysis of yeast-displayed libraries by flow cytometry, while libraries with insoluble or even as-yet-uncharacterized binding targets can be screened through cell-surface selections. In parallel, the utilization of yeast surface display for protein characterization, including in particular the mapping of funct...

  3. Functional Capacity Evaluation & Disability

    OpenAIRE

    Chen, Joseph J.

    2007-01-01

    Function, Impairment, and Disability are words in which many physicians have little interest. Most physicians are trained to deal with structure and physiology and not function and disability. The purpose of this article is to address some of the common questions that many physicians have with the use of functional capacity evaluation and disability and also to provide a unifying model that can explain the medical and societal variables in predicting disability. We will first define the funct...

  4. Iterative Mixture Component Pruning Algorithm for Gaussian Mixture PHD Filter

    OpenAIRE

    Xiaoxi Yan

    2014-01-01

    As far as the increasing number of mixture components in the Gaussian mixture PHD filter is concerned, an iterative mixture component pruning algorithm is proposed. The pruning algorithm is based on maximizing the posterior probability density of the mixture weights. The entropy distribution of the mixture weights is adopted as the prior distribution of mixture component parameters. The iterative update formulations of the mixture weights are derived by Lagrange multiplier and Lambert W funct...

  5. Methylprednisolone-hemisuccinate and its metabolites in serum, urine and bile from two patients with acute graft rejection.

    OpenAIRE

    Lawson, G. J.; Chakraborty, J; Tredger, J M; Baylis, E M

    1995-01-01

    Methylprednisolone-hemisuccinate (MPHS), methylprednisolone (MP), 20-alpha-hydroxy- (20 alpha HMP) and 20-beta-hydroxymethyl-prednisolone (20 beta HMP) concentrations were measured in serum, urine and bile from two liver transplant recipients who had received 1 g MPHS by a 1 h intravenous infusion for treatment of an acute rejection episode. These patients excreted similar total amounts of the dose in urine as patients with rheumatoid arthritis (historical controls) who had normal liver funct...

  6. Disulphide Bridges of Phospholipase C of Chlamydomonas reinhardtii Modulates Lipid Interaction and Dimer Stability

    OpenAIRE

    Mayanka Awasthi; Jyoti Batra; Suneel Kateriya

    2012-01-01

    BACKGROUND: Phospholipase C (PLC) is an enzyme that plays pivotal role in a number of signaling cascades. These are active in the plasma membrane and triggers cellular responses by catalyzing the hydrolysis of membrane phospholipids and thereby generating the secondary messengers. Phosphatidylinositol-PLC (PI-PLC) specifically interacts with phosphoinositide and/or phosphoinositol and catalyzes specific cleavage of sn-3- phosphodiester bond. Several isoforms of PLC are known to form and funct...

  7. On Some Quiver Determinantal Varieties

    OpenAIRE

    Fei, Jiarui

    2014-01-01

    We introduce certain quiver analogue of the determinantal variety. We study the Kempf-Lascoux-Weyman's complex associated to a line bundle on the variety. In the case of generalized Kronecker quivers, we give a sufficient condition on when the complex resolves a maximal Cohen-Macaulay module supported on the quiver determinantal variety. This allows us to find the set-theoretical defining equations of these varieties. When the variety has codimension one, the only irreducible polynomial funct...

  8. Toward Eradicating HIV Reservoirs in the Brain: Inhibiting P-glycoprotein at the Blood-Brain Barrier with Prodrug Abacavir Dimers

    OpenAIRE

    Namanja, Hilda A.; Emmert, Dana; Davis, David A.; Campos, Christopher; Miller, David S.; Hrycyna, Christine A.; Chmielewski, Jean

    2011-01-01

    Eradication of HIV reservoirs in the brain necessitates penetration of antiviral agents across the blood-brain barrier (BBB), a process limited by drug efflux proteins such as P-glycoprotein (P-gp) at the membrane of brain capillary endothelial cells. We present an innovative chemical strategy toward the goal of therapeutic brain penetration of the P-gp substrate and anti-viral agent abacavir, in conjunction with a traceless tether. Dimeric prodrugs of abacavir were designed to have two funct...

  9. Wage Mobility in East and West Germany

    OpenAIRE

    Regina T. Riphahn; Schnitzlein, Daniel D.

    2011-01-01

    This article studies the long run patterns and explanations of wage mobility as a characteristic of regional labor markets. Using German administrative data we describe wage mobility since 1975 in West and since 1992 in East Germany. Wage mobility declined substantially in East Germany in the 1990s and moderately in East and West Germany since the late 1990s. Therefore, wage mobility does not balance recent increases in cross-sectional wage inequality. We apply RIF (recentered influence funct...

  10. COLOR–THE ROLE OF COLOR IN PRODUCTS DESIGN PART II

    OpenAIRE

    L. D. Bordeianu; L. Hristian; I. G. Lupu

    2012-01-01

    The paper is analyzing the colors from sensorial-perceptive point of view point. The color, as one of the most important visual instruments can became a characteristic element of products, brands or company identification by using its special capabilities conveyed through technique. In trade, the color has a major role for advertising, packaging, and can and must communicate information about the quality and other characteristics of products. The principles that underlie the use and the funct...

  11. Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology

    OpenAIRE

    Holmes, Cheryl L; Landry, Donald W.; Granton, John T.

    2003-01-01

    Vasopressin is emerging as a rational therapy for vasodilatory shock states. Unlike other vasoconstrictor agents, vasopressin also has vasodilatory properties. The goal of the present review is to explore the vascular actions of vasopressin. In part 1 of the review we discuss structure, signaling pathways, and tissue distributions of the classic vasopressin receptors, namely V1 vascular, V2 renal, V3 pituitary and oxytocin receptors, and the P2 class of purinoreceptors. Knowledge of the funct...

  12. Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission

    OpenAIRE

    Zhang, Xuchen; Shan, Peiying; Homer, Robert; Zhang, Yi; Petrache, Irina; Mannam, Praveen; Lee, Patty J.

    2014-01-01

    Emphysema is characterized by loss of lung elasticity and irreversible air space enlargement, usually in the later decades of life. The molecular mechanisms of emphysema remain poorly defined. We identified a role for a novel cathepsin, cathepsin E, in promoting emphysema by inducing mitochondrial fission. Unlike previously reported cysteine cathepsins, which have been implicated in cigarette smoke-induced lung disease, cathepsin E is a nonlysosomal intracellular aspartic protease whose funct...

  13. The specificity of action knowledge in sensory and motor systems

    OpenAIRE

    Watson, Christine E.; Cardillo, Eileen R.; Bianca eBromberger; Anjan eChatterjee

    2014-01-01

    Neuroimaging studies have found that sensorimotor systems are engaged when participants observe actions or comprehend action language. However, most of these studies have asked the binary question of whether action concepts are embodied or not, rather than whether sensory and motor areas of the brain contain graded amounts of information during putative action simulations. To address this question, we used repetition suppression (RS) functional magnetic resonance imaging to determine if funct...

  14. Relativistic wave functions and energies for nonzero angular momentum states in light-front dynamics

    OpenAIRE

    Karmanov, V. A.; Mangin-Brinet, M.; Carbonell, J.

    2000-01-01

    Light-front dynamics (LFD) is a powerful approach to the theory of relativistic composite systems (hadrons in the quark models and relativistic nucleons in nuclei). Its explicitly covariant version has been recently applied with success to describe the new CEBAF/TJNAF data on the deuteron electromagnetic form factors. The solutions used in were however not obtained from solving exactly the LFD equations but by means of a perturbative calculation with respect to the non relativistic wave funct...

  15. A biochemical model for characterising the surface-active phospolipid bilayer of articular cartilage relative to acid-base equilibrium

    OpenAIRE

    Z. Pawlak; J. Kotynska; Figaszewski, Z A; A. Gadomski; A. Gudaniec; A. Oloyede

    2008-01-01

    Purpose: This paper, addresses the question of how changes in acid - base equilibrium influence change in thecharge density of the phospholipid bilayer on articular cartilage surfaces during lubrication.Design/methodology/approach: Liposomes have been used to mimic biological phospholipid membranes onarticular cartilage surface where proteins are bounded, ions are transported, energy is transducted, and cellular processestake place. The charge density of the membrane was determined as a funct...

  16. Orthogonal functionalization of nanoporous substrates: control of 3D surface functionality.

    OpenAIRE

    Thomas D. Lazzara; Kliesch, Torben-Tobias; Janshoff, Andreas; Steinem, Claudia

    2011-01-01

    Anodic aluminum oxide (AAO) membranes with aligned, cylindrical, nonintersecting pores were selectively functionalized in order to create dual-functionality substrates with different pore-rim and pore-interior surface functionalities, using silane chemistry. We used a two-step process involving an evaporated thin gold film to protect the underlying surface functionality of the pore rims. Subsequent treatment with oxygen plasma of the modified AAO membrane removed the unprotected organic funct...

  17. Local stability of perfect alignment for a spatially homogeneous kinetic model

    OpenAIRE

    Degond, Pierre; Frouvelle, Amic; Raoul, Gaël

    2014-01-01

    International audience We prove the nonlinear local stability of Dirac masses for a kinetic model of alignment of particles on the unit sphere, each point of the unit sphere representing a direction. A population concentrated in a Dirac mass then corresponds to the global alignment of all individuals. The main difficulty of this model is the lack of conserved quantities and the absence of an energy that would decrease for any initial condition. We overcome this difficulty thanks to a funct...

  18. Striving for a balance: Nature, power, science and India′s Indira Gandhi, 1917-1984

    OpenAIRE

    Rangarajan Mahesh

    2009-01-01

    Indira Gandhi′s life (1917-1984) spanned much of the twentieth century. She was Prime Minister of the world′s largest democracy for two spells that totaled fifteen years. To this day, her environmental legacy remains one that divides critics from admirers. One sees it as a defense against ecological impoverishment, especially in her initiation of wildlife preservation and environmental conservation. The other views these as thin legitimization for an authoritarian style of funct...

  19. Functional foods in human nutrition

    OpenAIRE

    ZEVLOVÁ, Veronika

    2013-01-01

    Bachelor thesis deals with functional food and their role in human nutrition. The history of functional food, their characteristics, components, evaluation of individual species and the impact on the health of the consumer is described here. A lot of researches are focused on the topic of functional food, but no legally definition have been established yet. Even in the Czech Republic or the EU. Only the certain designations are used, which have a small deviations in different countries. Funct...

  20. Health Considerations Regarding Horizontal Transfer of Microbial Transgenes Present in Genetically Modified Crops

    OpenAIRE

    Gijs A. Kleter; Peijnenburg, Ad A. C. M.; Aarts, Henk J.M.

    2005-01-01

    The potential effects of horizontal gene transfer on human health are an important item in the safety assessment of genetically modified organisms. Horizontal gene transfer from genetically modified crops to gut microflora most likely occurs with transgenes of microbial origin. The characteristics of microbial transgenes other than antibiotic-resistance genes in market-approved genetically modified crops are reviewed. These characteristics include the microbial source, natural function, funct...

  1. Functional independence measure in patients with intermittent claudication

    OpenAIRE

    Caroline Shihara de Assis; Letícia de Carvalho Batista; Nelson Wolosker; Antonio Eduardo Zerati; Rita de Cassia Gengo e Silva

    2015-01-01

    AbstractOBJECTIVEOf this study were to evaluate the functional independence of patients with intermittent claudication and to verify its association with sociodemographic and clinical variables, walking ability and physical activity level.METHODThis was a descriptive, exploratory, cross-sectional study with a quantitative approach. Fifty participants (66.4 years; 68% male) were recruited from Claudication Unit of a tertiary hospital. Functional Independence Measure were used to evaluate funct...

  2. Sırrı Paşa (Fidangör) Yaya Bölgesinin Engelli Kullanımı Açısından Ulaşılabilirliğinin Değerlendirilmesi

    OpenAIRE

    Akbaş, Hazal Bengühan; Atabeyoğlu, Ömer

    2015-01-01

    ABSCART The people need to opportunity of harboring, education, working, social, cultural and recreation. These opportunities have attainableness for all people that are using to same living spaces. The design is appropriate, when the living environments have equal opportunities for all people. Disability hasn't some abilities as physical and sensorial. Disabled people come across many factors that restrict to use urban functions. The attainableness provides to use maximum to urban funct...

  3. Cognitive and Academic Outcomes after Pediatric Liver Transplantation: Functional Outcomes Group (FOG) Results

    OpenAIRE

    Sorensen, L.G.; Neighbors, K.; Martz, K.; Zelko, F.; Bucuvalas, J.C.; Alonso, E. M.

    2011-01-01

    This multi-center study examined prevalence of cognitive and academic delays in children following liver transplant (LT). 144 patients ages 5–7 and 2 years post-LT were recruited through the SPLIT consortium and administered the Wechsler Preschool and Primary Scale of Intelligence, 3rd Edition (WPPSI-III), the Bracken Basic Concept Scale, Revised (BBCS-R), and the Wide Range Achievement Test, 4th edition (WRAT-4). Parents and teachers completed the Behavior Rating Inventory of Executive Funct...

  4. Effect of a high-intensity exercise program on physical function and mental health in nursing home residents with dementia: An assessor blinded randomized controlled trial

    OpenAIRE

    Elisabeth Wiken Telenius; Knut Engedal; Astrid Bergland

    2016-01-01

    Background Dementia is among the leading causes of functional loss and disability in older adults. Research has demonstrated that nursing home patients without dementia can improve their function in activities of daily living, strength, balance and mental well being by physical exercise. The evidence on effect of physical exercise among nursing home patients with dementia is scarce and ambiguous. Thus, the primary objective of this study was to investigate the effect of a high intensity funct...

  5. Cerebral White Matter Integrity and Resting-State Functional Connectivity in Middle-aged Patients With Type 2 Diabetes

    OpenAIRE

    Hoogenboom, Wouter S.; Marder, Thomas J.; Flores, Veronica L.; Huisman, Susanne; Eaton, Hana P.; Schneiderman, Jason S.; Bolo, Nicolas R.; Simonson, Donald C.; Jacobson, Alan M.; Kubicki, Marek; Martha E. Shenton; Musen, Gail

    2014-01-01

    Early detection of brain abnormalities at the preclinical stage can be useful for developing preventive interventions to abate cognitive decline. We examined whether middle-aged type 2 diabetic patients show reduced white matter integrity in fiber tracts important for cognition and whether this abnormality is related to preestablished altered resting-state functional connectivity in the default mode network (DMN). Diabetic and nondiabetic participants underwent diffusion tensor imaging, funct...

  6. Factors associated with depression in pediatric cancer patients, and participation of nursing in its detection

    OpenAIRE

    Sandra Velásquez-Silva; Lina Zuluaga-Sarmiento

    2015-01-01

    The objective of this work is to describe what are the factors associated with depression in pediatric patients with cancer and how nurses can participate in its detection. We conducted an integrative review of articles published between 2000 and 2012. Fifteen articles were selected and then critically analyzed and organized by subjects according to their purpose. Among factors associated with depression are the following: personal factors: adaptability, developmental level and physical funct...

  7. Un Sistema vegetato per la biorimediation di un suolo inquinato da metalli pesanti e idrocarburi: "Il caso di Madonna dell'Acqua in Toscana"

    OpenAIRE

    Manca, Agata

    2009-01-01

    This work is a part of a project carried out by CNR-ISE – Pisa, in collaboration with S. Giuliano Terme (Pisa) Municipality. Aim of the project was to test and apply bioremediation techniques to a heavy metal and hydrocarbon contaminated site (Madonna dell’Acqua, Tuscany). The bioremediation system studied included the use of plants, earthworms and organic matter. The final objectives were dual: decontamination and biophysical regeneration of soil in order to recover its ecological funct...

  8. Python library reference

    OpenAIRE

    Rossum, van, M.A.J.

    1995-01-01

    Python is an extensible, interpreted, object-oriented programming language. It supports a wide range of applications, from simple text processing scripts to interactive WWW browsers. While the Python Reference Manual describes the exact syntax and semantics of the language, it does not describe the standard library that is distributed with the language, and which greatly enhances its immediate usability. This library contains built-in modules (written in C) that provide access to system funct...

  9. Animal models of attention-deficit hyperactivity disorder

    OpenAIRE

    Sagvolden Terje; Russell Vivienne A; Johansen Espen

    2005-01-01

    Abstract Although animals cannot be used to study complex human behaviour such as language, they do have similar basic functions. In fact, human disorders that have animal models are better understood than disorders that do not. ADHD is a heterogeneous disorder. The relatively simple nervous systems of rodent models have enabled identification of neurobiological changes that underlie certain aspects of ADHD behaviour. Several animal models of ADHD suggest that the dopaminergic system is funct...

  10. Simulation study of a gramicidin/lipid bilayer system in excess water and lipid. I. Structure of the molecular complex.

    OpenAIRE

    Chiu, S. W.; Subramaniam, S.; Jakobsson, E.

    1999-01-01

    This paper reports on a simulation of a gramicidin channel inserted into a fluid phase DMPC bilayer with 100 lipid molecules. Two lipid molecules per leaflet were removed to insert the gramicidin, so the resulting preparation had 96 lipid molecules and 3209 water molecules. Constant surface tension boundary conditions were employed. Like previous simulations with a lower lipid/gramicidin ratio (Woolf, T. B., and B. Roux. 1996. Proteins: Struct., Funct., Genet. 24:92-114), it is found that try...

  11. A characterization of Poisson-Gaussian families by generalized variance

    OpenAIRE

    Kokonendji, Célestin C.; Masmoudi, Afif

    2006-01-01

    We show that if the generalized variance of an infinitely divisible natural exponential family [math] in a [math] -dimensional linear space is of the form [math] , then there exists [math] in [math] such that [math] is a product of [math] univariate Poisson and ( [math] )-variate Gaussian families. In proving this fact, we use a suitable representation of the generalized variance as a Laplace transform and the result, due to Jörgens, Calabi and Pogorelov, that any strictly convex smooth funct...

  12. Saturated- and n-6 Polyunsaturated-Fat Diets Each Induce Ceramide Accumulation in Mouse Skeletal Muscle: Reversal and Improvement of Glucose Tolerance by Lipid Metabolism Inhibitors

    OpenAIRE

    Frangioudakis, G.; J. Garrard; Raddatz, K.; Nadler, J L; Mitchell, T. W.; Schmitz-Peiffer, C.

    2010-01-01

    Lipid-induced insulin resistance is associated with intracellular accumulation of inhibitory intermediates depending on the prevalent fatty acid (FA) species. In cultured myotubes, ceramide and phosphatidic acid (PA) mediate the effects of the saturated FA palmitate and the unsaturated FA linoleate, respectively. We hypothesized that myriocin (MYR), an inhibitor of de novo ceramide synthesis, would protect against glucose intolerance in saturated fat-fed mice, while lisofylline (LSF), a funct...

  13. A platform for dynamic simulation and control of movement based on OpenSim and MATLAB

    OpenAIRE

    Mansouri, Misagh; Reinbolt, Jeffrey A.

    2012-01-01

    Numerical simulations play an important role in solving complex engineering problems and have the potential to revolutionize medical decision making and treatment strategies. In this paper, we combine the rapid model-based design, control systems and powerful numerical method strengths of MATLAB/Simulink with the simulation and human movement dynamics strengths of OpenSim by developing a new interface between the two software tools. OpenSim is integrated with Simulink using the MATLAB S-funct...

  14. Semaphorin 3A Suppresses Tumor Growth and Metastasis in Mice Melanoma Model

    OpenAIRE

    Chakraborty, Goutam; Kumar, Santosh; Mishra, Rosalin; Tushar V Patil; Kundu, Gopal C.

    2012-01-01

    Background Recent understanding on cancer therapy indicated that targeting metastatic signature or angiogenic switch could be a promising and rational approach to combat cancer. Advancement in cancer research has demonstrated the potential role of various tumor suppressor proteins in inhibition of cancer progression. Current studies have shown that axonal sprouting inhibitor, semaphorin 3A (Sema 3A) acts as a potent suppressor of tumor angiogenesis in various cancer models. However, the funct...

  15. Energy from Waste: Generation Potential and Mitigation Opportunity

    OpenAIRE

    Bosello, Francesco; Campagnolo, Lorenza; Eboli, Fabio; Parrado, Ramiro

    2014-01-01

    The present research proposes a macroeconomic assessment of the role of waste incineration with energy recovery (WtE) and controlled landfill biogas to electricity generation and their potential contribution to a CO2 emission reduction policy, within a recursive-dynamic computable general equilibrium model. From the modelling viewpoint, introducing these energy sectors in such a framework required both the extension of the GTAP7 database and the improvement of the ICES production nested funct...

  16. Shortness of Breath and Lower Limb Edema in a 54-Year-Old Woman, Is There Any Cure?

    OpenAIRE

    Frogoudaki, Alexandra; S. Triantafyllis, Andreas; Vassilatou, Evangeline; Tsamakis, Charalampos; Zacharoulis, Achilles; Lekakis, John

    2015-01-01

    Introduction: Pulmonary hypertension is common among patients with hyperthyroidism, and Graves’ disease constitutes the most common cause of thyrotoxicosis. Case Presentation: We report the case of a female patient admitted to the cardiology department with shortness of breath and pretibial myxedema. The diagnostic work-up revealed combined pre- and post-capillary pulmonary hypertension due to Graves’ disease superimposed on left ventricular diastolic dysfunction. Restoration of thyroid funct...

  17. Managing a South African organisation within a dual manufacturing and services economy

    OpenAIRE

    Weeks, R; S. Benade

    2008-01-01

    Purpose: The purpose of this paper is to analyse the nature of the South African dual manufacturing and services economy and the impact thereof on organisations from a management perspective. Problem investigated: Services account for over 65% of South Africa's gross domestic product (GDP) and reflects an escalating trend. The manufacturing sector of the economy is just over 26% of GDP. This by implication implies that the South African economy is dualistic in nature. The economy funct...

  18. Photovoltage versus microprobe sheet resistance measurements on ultrashallow structures

    DEFF Research Database (Denmark)

    Clarysse, T.; Moussa, A.; Parmentier, B.;

    2010-01-01

    Earlier work [T. Clarysse , Mater. Sci. Eng., B 114-115, 166 (2004); T. Clarysse , Mater. Res. Soc. Symp. Proc. 912, 197 (2006)] has shown that only few contemporary tools are able to measure reliably (within the international technology roadmap for semiconductors specifications) sheet resistances...... on ultrashallow (sub-50-nm) chemical-vapor-deposited layers [T. Clarysse , Mater. Res. Soc. Symp. Proc. 912, 197 (2006)], especially in the presence of medium/highly doped underlying layers (representative for well/halo implants). Here the authors examine more closely the sheet resistance anomalies...

  19. Degradação da matéria seca e da proteína bruta de silagens de milho sem espigas com cana-de-açúcar e bagaço de mandioca - DOI: 10.4025/actascianimsci.v28i4.605 Dry mater and crude protein ruminal degradation of corn silage without spikes with sugar cane and manioc pulp - DOI: 10.4025/actascianimsci.v28i4.605

    Directory of Open Access Journals (Sweden)

    Paulo Rossi Junior

    2006-02-01

    Full Text Available A degradação ruminal da matéria seca (MS e da proteína bruta (PB de silagen s de milho sem espigas (SMSE com cana -de-açúcar (CA e bagaço seco de mandioca (BSM, comparadas com a silagem de milho com espigas (SMCE, foi avaliada. A ensilagem foi feita com (CI e sem inoculante (SI - Lactobacillus plantarum e L paracasei ssp. paracasei. Estudaram-se: as frações solúvel (A, potencialmente degradável (B e não degradável (C; a taxa de degradação da fração B (c; a degradabilidade efetiva (DE e potencial (DP, para os tratamentos: T1 (SMSE+20% CA -SI; T2 (SMSE+20% CA -CI; T3 (SMSE+35% CASI; T4 (SMSE+35% CA-CI; T5 (SMSE+20% BSM-SI; T6 (SMSE+20% BSM-CI; T7 (SMSE+35% BSM-SI; T8 (SMSE+35% BSM-CI; T9 (SMCE-SI e T10 (SMCE-CI. As médias foram comparadas num delineamento inteiramente casualisado. Houve diferença (P0,05. A adição de BSM (20 e 35% às SMSE aumentou (PThe goal of this work was to evaluate the ruminal degradation of corn silages without spikes (CSWS, added with sugar cane (SC and dry manioc pulp (DMP, as compared as corn silage (CS. The foods were ensiled with (WI and without (IF inoculant’s, composed by Lactobacillus plantarum and L. paracasei ssp. paracasei. The following fractions have been studied: water soluble (A, potentially degradable (B, non degradable (C, fraction B degradable ratio (c; effective (ED and potential (PD degradability. The treatments evaluated were: T1 (CSWS + 20% SC -IF; T2 (CSWS + 20% SC-WI; T3 (CSWS + 35% SC -IF; T4 (CSWS + 35% SC -WI; T5 (CSWS + 20% DMP-IF; T6 (CSWS + 20% DMP -WI; T7 (CSWS + 35% DMP -IF; T8 (CSWS + 35% DMP-WI; T9 (CS-WI and T10 (CS-IF. The average differences have been compared on a completely randomized model. Difference (P 0.05 for all treatments. Dry manioc pulp added to the non spikes corn silage (20 and 35% - DM basis, has allowed the rise of the DM fraction B, indicating the possibility to add up to 35% of dry manioc pulp on corn silage, inst ead of green spikes.

  20. 电刺激大鼠上矢状窦区硬脑膜后血浆与脑组织中降钙素基因相关肽、P物质和前列腺素 E2释放差异%Release difference of calcitonin gene-related peptide,substance P and prostaglandin E2 in orbital venous plexus plasma and brain tissues from rats with dura mater of superior sagittal sinus following electrical stimulation

    Institute of Scientific and Technical Information of China (English)

    陈健; 吕新勇; 孙晓萍; 陈春苗; 周军; 王振中; 萧伟

    2014-01-01

    OBJECTIVE Toexplorethefeasibilityofpreparingamigrainemodelusingratdura materofsuperiorsagittalsinusinfollowingelectricalstimulation.METHODS MaleSDratswereexposed to 1 h electrical stimulation after brain electrode implantation,at 3 V,6 Hz,and a pulse of 0.25 ms.At 0, 1 5,30 min,and 1 h,orbital blood and brain tissue were taken.The content of calcitonin gene-related peptide (CGRP),substance P and prostaglandin E2 (PGE2 )in the plas ma and brain tissue was detec-tedbyradioimmunoassay.RESULTS ThebraintissuecontentofCGRP,substancePandPGE2in the sham group and normal group was not significantly different.CGRP,substance P and PGE2 in brain tissue of model group were 3.41 ±0.93,1 .80 ±0.64,3.41 ±0.93 and (1 .80 ±0.64)ng·g -1 respec-tively,significantly different from sham group(P<0.05).At different time points,the content of CGRP, substance P and PGE2 in plasma orbital venous plexus showed no significant difference between sham groupandmodelgroup.CONCLUSION ThereleaseofCGRP,PGE2andsubstancePinbraintissue is significantly different fro m that of plas ma after electrical sti mulation.The results suggest that a model of migraine can be constructed by electrical stimulation.%目的:探讨电刺激大鼠上矢状窦区硬脑膜制备偏头痛模型的可行性。方法雄性SD 大鼠,脑部电极植入术后行电压3 V、频率6 Hz、脉宽0.25 ms、时间1 h电刺激,并于刺激0,15和30 min和1 h进行眼眶采血,采血后取脑组织。采用放射免疫法检测血浆和脑组织中降钙素基因相关肽(CGRP)、P物质和前列腺素E2(PGE2)含量。结果手术对照组与正常对照组大鼠脑组织中 CGRP 含量、P 物质含量和PGE2含量为均无显著性差异;模型组大鼠脑组织中CGRP、P物质和 PGE2分别为3.41±0.93,1.80±0.64和(5.17±0.69)ng·g -1,与手术对照组大鼠相比均有显著性差异(P<0.05)。各时间点手术对照组与模型组大鼠外周静脉血浆中CGRP、P物质和PGE2含量无显著性差异。结论电刺激大鼠上矢状窦区硬脑膜后,脑组织中CGRP、PGE2和P物质水平与外周静脉血中显著不同,表明可采用本方法制备偏头痛模型。

  1. Degradação da matéria seca e da proteína bruta de silagens de milho sem espigas com cana-de-açúcar e bagaço de mandioca - DOI: 10.4025/actascianimsci.v28i4.605 Dry mater and crude protein ruminal degradation of corn silage without spikes with sugar cane and manioc pulp - DOI: 10.4025/actascianimsci.v28i4.605

    OpenAIRE

    Paulo Rossi Junior; Carlos Ricardo Soccol; Nina Waszczynskyj; Marcos Elias Traad da Silva; Leandro Cavalcante Lipinski

    2006-01-01

    A degradação ruminal da matéria seca (MS) e da proteína bruta (PB) de silagen s de milho sem espigas (SMSE) com cana -de-açúcar (CA) e bagaço seco de mandioca (BSM), comparadas com a silagem de milho com espigas (SMCE), foi avaliada. A ensilagem foi feita com (CI) e sem inoculante (SI) - Lactobacillus plantarum e L paracasei ssp. paracasei. Estudaram-se: as frações solúvel (A), potencialmente degradável (B) e não degradável (C); a taxa de degradação da fração B (c); a degradabilidade efetiva ...

  2. Disease: H00594 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available pathogenesis of distal muscular dystrophies. Adv Exp Med Biol 652:23-38 (2009) PMID:17029922 (gene, description) Udd B Molecular biol...ogy of distal muscular dystrophies--sarcomeric proteins on top. Biochim Biophys Act

  3. Direct solid-phase radioimmunoassay for the detection of Aujeszky's disease antibodies

    International Nuclear Information System (INIS)

    A direct solid-phase radioimmunoassy (dRIA) was developed in order to demonstrate antibodies against Aujeszky's disease virus (ADV) in sera obtained from pigs and rabbits. In the presence of guinea-pig complement the above test is 160-fold to 1500-fold more sensitive than the neutralization test (NT) and 320-fold to 150 000-fold more sensitive than sera obtained from an ADV-infected farm, which were found to be negative in the complement assisted NT. It is possible to test a single dilution of unknown serum by dRIA by comparing same with a standard curve and to make a statement regarding its ADV-specific binding capacity to 125I-labelled ADV antigen. The advantages of dRIA in comparison to the indirect RIA and the advantages and disadvantages with regard to ELISA were discussed. (orig.)

  4. Neutrophil surface adhesion molecule and toll like receptor dynamics in crossbred cows suffering from Staphylococcus aureus subclinical and clinical mastitis

    Directory of Open Access Journals (Sweden)

    Dilip Kumar Swain

    2016-06-01

    Conclusion: Host elicits stage specific expression of surface adhesion molecules and TLR2 and TLR4 as dynamic host innate immune response against Staphylococcal mastitis. [J Adv Vet Anim Res 2016; 3(2.000: 99-105

  5. The Design and Characterization of Wideband Spline-profiled Feedhorns for Advanced Actpol

    Science.gov (United States)

    Simon, Sara M.; Austermann, Jason; Beall, James A.; Choi, Steve K.; Coughlin, Kevin P.; Duff, Shannon M.; Gallardo, Patricio A.; Henderson, Shawn W.; Hills, Felicity B.; Ho, Shuay-Pwu Patty; Hubmayr, Johannes; Josaitis, Alec; Koopman, Brian J.; McMahon, Jeff J.; Nati, Federico; Newburgh, Laura; Niemack, Michael D.; Salatino, Maria; Schillaci, Alessandro; Wollack, Edward J.

    2016-01-01

    Advanced ACTPol (AdvACT) is an upgraded camera for the Atacama Cosmology Telescope (ACT) that will measure the cosmic microwave background in temperature and polarization over a wide range of angular scales and five frequency bands from 28-230 GHz. AdvACT will employ four arrays of feedhorn-coupled, polarization- sensitive multichroic detectors. To accommodate the higher pixel packing densities necessary to achieve Ad- vACTs sensitivity goals, we have developed and optimized wideband spline-profiled feedhorns for the AdvACT multichroic arrays that maximize coupling efficiency while carefully controlling polarization systematics. We present the design, fabrication, and testing of wideband spline-profiled feedhorns for the multichroic arrays of AdvACT.

  6. Ridge Waveguide Structures in Magnesium-Doped Lithium Niobate Project

    Data.gov (United States)

    National Aeronautics and Space Administration — AdvR, Inc. proposes the development of an efficient process for fabricating ridge waveguides in magnesium-doped lithium niobate (MgO:LN). The effort will include,...

  7. Highly Efficient, Compact, Wavelength Converters for Pulsed and CW Laser Sources Used in Lidar-Based Remote Sensing and Ranging Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — AdvR, Inc. proposes the development of a highly efficient, fiber pigtailed, waveguide-based UV frequency converter module. This UV module will be an important...

  8. Guidelines for submitting adverse event reports for publication

    NARCIS (Netherlands)

    Kelly, William; Arellano, Felix; Barnes, Joanne; Bergman, Ulf; Edwards, Ralph; Fernandez, Alina; Freedman, Stephen; Goldsmith, David; Huang, Kui; Jones, Judith; McLeay, Rachel; Moore, Nicholas; Stather, Rosie; Trenque, Thierry; Troutman, William; van Puijenbroek, Eugène; Williams, Frank; Wise, Robert

    2009-01-01

    Publication of case reports describing suspected adverse effects of drugs and medical products that include herbal and complementary medicines, vaccines and other biologicals and devices is important for postmarketing surveillance. Publication lends credence to important signals raised in these adve

  9. Checking the Goldbach conjecture on a vector computer

    NARCIS (Netherlands)

    Granville, A.; Lune, J. van de; Riele, H.J.J. te

    1989-01-01

    bibliographical data to be processed -- Number theory and applications (Banff, AB, 1988) Pages: 423--433 Series: NATO Adv. Sci. Inst. Ser. C Math. Phys. Sci. Vol: 265 -- Kluwer Acad. Publ. (Dordrecht) -- 10

  10. High Fidelity Down-Conversion Source for Secure Communications using On-Demand Single Photons Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this NASA SBIR Phase II effort, AdvR will design and build an efficient, fully integrated, waveguide based, source of spectrally uncorrelated photon pairs that...

  11. Multi-channel tunable source for atomic sensors Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR will establish the feasibility of developing compact, robust, integrated components suitable for atomic interferometry. AdvR's design is enabled...

  12. Antibody-forming cells and serum hemolysin responses of pastel and sapphire mink inoculated with Aleutian disease virus.

    Science.gov (United States)

    Lodmell, D L; Bergman, R K; Hadlow, W J

    1973-11-01

    The effect of Aleutian disease virus (ADV) on serum hemolysin titers and antibody-forming cells in lymph nodes and spleens of sapphire and pastel mink inoculated with goat erythrocytes (G-RBC) was investigated. ADV injected 1 day after primary antigenic stimulation with G-RBC did not depress the immune responses of either color phase for a period of 26 days. However, when G-RBC were injected 47 days after ADV, both the number of antibody-forming cells and hemolysin titers were more markedly depressed in sapphire than in pastel mink. The results are discussed in relation to the greater susceptibility of sapphire mink and the variable susceptibility of pastel mink to the Pullman isolate of ADV.

  13. Demonstration of Aleutian disease virus-specific lymphocyte response in mink with progressive Aleutian disease: comparison of sapphire and pastel mink infected with different virus strains.

    Science.gov (United States)

    Race, R E; Bloom, M E; Coe, J E

    1983-09-01

    Lymphocyte blastogenesis was used to study the antiviral lymphocyte response of sapphire (Aleutian) and pastel (nonAleutian) mink inoculated with Pullman or Utah 1 Aleutian disease virus (ADV). Both mink genotypes developed a virus-specific response when inoculated with Utah 1 ADV. In contrast, after inoculation of Pullman ADV, sapphire mink had a positive virus-specific response, whereas pastel mink did not. Response occurred late after infection (8 wk) and correlated with the development of progressive Aleutian disease (AD). The response to keyhole limpet hemocyanin (KLH) and concanavalin A (Con A) was also determined. Most mink of either genotype, inoculated with either virus strain, maintained an anti-KLH response during disease. Most mink also responded to Con A, although some exhibited suppressed Con A response late in the disease course. These results indicated that mink develop an anti-ADV lymphocyte response during progressive AD and are not immunosuppressed with regard to other antigens or mitogens.

  14. Disease: H01047 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available . Adv Parasitol 61:509-66 (2006) PMID:16337431 (description) Montresor A, Palmer K Taeniasis/cysticercosis trend worldwide and ration...ale for control. Parasitol Int 55 Suppl:S301-3 (2006) PM

  15. Promoting the demoted

    DEFF Research Database (Denmark)

    Jensen, Torben Juel; Christensen, Tanya Karoli

    2013-01-01

    In this article, we investigate a hypothesis regarding the distinction between the word orders ‘finite verb, adverb’ (V>Adv, in Scandinavian linguistics often considered an instance of V2, also in subject initial clauses) and ‘adverb, finite verb’ (Adv>V, sometimes referred to as V3) in Mainland ...... seemingly in conflict with predictions of the semantico-pragmatic hypothesis are discussed with respect to possible norm conflicts and shifts in communicative strategy during speech production....

  16. Technical Needs for Prototypic Prognostic Technique Demonstration for Advanced Small Modular Reactor Passive Components

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Ryan M.; Coble, Jamie B.; Hirt, Evelyn H.; Ramuhalli, Pradeep; Mitchell, Mark R.; Wootan, David W.; Berglin, Eric J.; Bond, Leonard J.; Henager, Charles H.

    2013-05-17

    This report identifies a number of requirements for prognostics health management of passive systems in AdvSMRs, documents technical gaps in establishing a prototypical prognostic methodology for this purpose, and describes a preliminary research plan for addressing these technical gaps. AdvSMRs span multiple concepts; therefore a technology- and design-neutral approach is taken, with the focus being on characteristics that are likely to be common to all or several AdvSMR concepts. An evaluation of available literature is used to identify proposed concepts for AdvSMRs along with likely operational characteristics. Available operating experience of advanced reactors is used in identifying passive components that may be subject to degradation, materials likely to be used for these components, and potential modes of degradation of these components. This information helps in assessing measurement needs for PHM systems, as well as defining functional requirements of PHM systems. An assessment of current state-of-the-art approaches to measurements, sensors and instrumentation, diagnostics and prognostics is also documented. This state-of-the-art evaluation, combined with the requirements, may be used to identify technical gaps and research needs in the development, evaluation, and deployment of PHM systems for AdvSMRs. A preliminary research plan to address high-priority research needs for the deployment of PHM systems to AdvSMRs is described, with the objective being the demonstration of prototypic prognostics technology for passive components in AdvSMRs. Greater efficiency in achieving this objective can be gained through judicious selection of materials and degradation modes that are relevant to proposed AdvSMR concepts, and for which significant knowledge already exists. These selections were made based on multiple constraints including the analysis performed in this document, ready access to laboratory-scale facilities for materials testing and measurement, and

  17. Measuring Turbulence from Moored Acoustic Doppler Velocimeters. A Manual to Quantifying Inflow at Tidal Energy Sites

    Energy Technology Data Exchange (ETDEWEB)

    Kilcher, Levi [National Renewable Energy Lab. (NREL), Golden, CO (United States); Thomson, Jim [Univ. of Washington, Seattle, WA (United States); Talbert, Joe [Univ. of Washington, Seattle, WA (United States); DeKlerk, Alex [Univ. of Washington, Seattle, WA (United States)

    2016-03-01

    This work details a methodology for measuring hub height inflow turbulence using moored acoustic Doppler velocimiters (ADVs). This approach is motivated by the shortcomings of alternatives. For example, remote velocity measurements (i.e., from acoustic Doppler profilers) lack sufficient precision for device simulation, and rigid tower-mounted measurements are very expensive and technically challenging in the tidal environment. Moorings offer a low-cost, site-adaptable and robust deployment platform, and ADVs provide the necessary precision to accurately quantify turbulence.

  18. Association of Human Adenovirus-36 With Dyslipidemia in Tehranian Children and Adolescent; TLGS

    Directory of Open Access Journals (Sweden)

    Zarkesh

    2015-04-01

    Full Text Available Background The human adenovirus-36 (Adv36 has been associated with obesity and lipid disorders in some countries. The primary dyslipidemia related to obesity is characterized by increased TG, decreased HDL levels and abnormal LDL composition. Childhood obesity is a major public health problem in most developing countries. Objectives The aim of this study was to investigate the association between Adv36 and lipid disorders in Tehranian youth. Patients and Methods In a cross-section/observational study, anthropometric, blood pressure and biochemical measurements were examined in 54 youth, aged below 19 years, selected randomly from participants of Tehran Lipid and Glucose Study (TLGS of Iran. Human Adv36 antibody of serum was determined using ELISA method. Results Of 54 youth, with a mean age of 14.78 ± 2.62 years, 85.2% were Adv36 seropositive (N = 46 and 14.8% were seronegative (N = 8. Subjects with Adv36 seropositive had higher mean of age, weight, TC, LDL-C, TG and SBP and lower level of HDL-C, waist, FBS and DBP. The unadjusted OR for elevated TG increased in participants who were Adv36 seropositive (OR 3.062, 95% CI: 0.344-27.293. Although the unadjusted OR for other lipid variables, such as elevated TC and LDL-C or decreased HDL-C, tended to increase in participants who were Adv36 seropositive (OR 1.028, 95% CI: 0.996 - 1.060; OR 1.057, 95% CI: 0.107 - 10.481; OR 1.125, 95% CI: 0.238 - 5.325, respectively, the results were not significant. Conclusions It seems that seropositive Adv36 has a strong association with lipid disorders, especially elevated TG level in Tehranian children and adolescent.

  19. Role of alveolar type II cells and of surfactant-associated protein C mRNA levels in the pathogenesis of respiratory distress in mink kits infected with Aleutian mink disease parvovirus.

    OpenAIRE

    Viuff, B; Aasted, B; Alexandersen, S.

    1994-01-01

    Neonatal mink kits infected with Aleutian mink disease parvovirus (ADV) develop an acute interstitial pneumonia with clinical symptoms and pathological lesions that resemble those seen in preterm human infants with respiratory distress syndrome and in human adults with adult respiratory distress syndrome. We have previously suggested that ADV replicates in the alveolar type II epithelial cells of the lung. By using double in situ hybridization, with the simultaneous use of a probe to detect A...

  20. Novel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions.

    OpenAIRE

    Wevers, Diana; Metzger, Sonja; Babweteera, Fred; Bieberbach, Marc; Boesch, Christophe; Cameron, Kenneth; Couacy-Hymann, Emmanuel; Cranfield, Mike; Gray, Maryke; Harris, Laurie A.; Head, Josephine; Jeffery, Kathryn; Knauf, Sascha; Lankester, Felix; Siv Aina J. Leendertz

    2011-01-01

    Adenoviruses (AdVs) broadly infect vertebrate hosts, including a variety of nonhuman primates (NHPs). In the present study, we identified AdVs in NHPs living in their natural habitats, and through the combination of phylogenetic analyses and information on the habitats and epidemiological settings, we detected possible horizontal transmission events between NHPs and humans. Wild NHPs were analyzed with a pan-primate AdV-specific PCR using a degenerate nested primer set that targets the highly...

  1. Association of Human Adenovirus-36 With Dyslipidemia in Tehranian Children and Adolescent; TLGS

    OpenAIRE

    Zarkesh; Sadat Daneshpour; Ehsandar; Bandehpour; Alfadhli; Azizi; Hedayati

    2015-01-01

    Background The human adenovirus-36 (Adv36) has been associated with obesity and lipid disorders in some countries. The primary dyslipidemia related to obesity is characterized by increased TG, decreased HDL levels and abnormal LDL composition. Childhood obesity is a major public health problem in most developing countries. Objectives The aim of this study was to investigate the association between Adv36 and lipid disorders in Tehr...

  2. Estimating Operational Risk for Hedge Funds: The ?-Score

    OpenAIRE

    Stephen Brown; William Goetzmann; Bing Liang; Christopher Schwarz

    2008-01-01

    Using a complete set of the SEC filing information on hedge funds (Form ADV) and the TASS data, we develop a quantitative model called the ?-Score to measure hedge fund operational risk. The ?-Score is related to conflict of interest issues, concentrated ownership, and reduced leverage in the ADV data. With a statistical methodology, we further relate the ?-Score to readily available information such as fund performance, volatility, size, age, and fee structures. Finally, we demonstrate that ...

  3. Imaging nanomaterials in vitro and in vivo by exploring their intrinsic nonlinear optical signals

    Science.gov (United States)

    Tong, Ling

    . First, receptor-medicated endocytosis is visualized with a polymeric nanoparticle-based CARS probe (J. Phys. Chem. B, 2007, 111, 9980-9985). Second, the cellular drug delivery mechanism by poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) is reexamined by CARS microscopy and new discoveries that PLGA NPs are not readily taken up by cells and delivered the payload to cells by extracellular drug release and/or direct drug transfer to contacting cells are found (Mol. Pharmaceutics, 2009, 6, 190-201). Third, the sensitivity of SRS microscopy is improved to monitor liposomal drug delivery in live cells. The last part of my thesis depicts the applications of GNRs in diagnosis and phtotothermal therapy of tumor cells and activated macrophages. Photothermal effect of GNRs is monitored by TPL, confocal microscopy and biological assays. The formation of membrane blebs is observed. The subcellular mechanism is investigated to be a downstream effect of compromised membrane integrity, which permits influx of calcium and subsequent disruption of the actin network (Adv. Mater. 2007, 109, 3136-3141, cover story). In addition, cell death through necrosis or apoptosis is induced by controlling laser irradiation. The molecular mechanisms are determined as the loss of plasma membrane integrity for necrosis and intracellular perturbation with damage of mitochondria for apoptosis (Nanomedicine, 2009, 4, 265-276).

  4. Influence of mycorhization and soil organic matters on lead and antimony transfers to vegetables cultivated in urban gardens: environmental and sanitary consequences

    Science.gov (United States)

    Pierart, Antoine; Braud, Armelle; Lebeau, Thierry; Séjalon-Delmas, Nathalie; Dumat, Camille

    2014-05-01

    . References: Feng, R., Wei, C., Tu, S., Ding, Y., Wang, R., Guo, J., 2013. The uptake and detoxification of antimony by plants: a review. Environ. Exp. Bot. 96, 28-34. Foucault, Y., Lévêque, T., Xiong, T., Schreck, E., Austruy, A., Shahid, M., Dumat, C., 2013. Green manure plants for remediation of soils polluted by metals and metalloids: Ecotoxicity and human bioavailability assessment. Chemosphere 93, 1430-1435. Gu, H.H., Li, F.P., Yu, Q., Gao, Y.Q., Yuan, X.T., 2013. The Roles of Arbuscular Mycorrhizal Fungus Glomus mosseae and Festuca arundinacea in Phytostabilization of Lead/Zinc Tailings. Adv. Mater. Res. 699, 245-250. Lebeau, T., Braud, A., Jézéquel, K., 2008. Performance of bioaugmentation-assisted phytoextraction applied to metal contaminated soils: A review. Environ. Pollut. 153, 497-522. Sharma, A., Sharma, H., 2013. Role of Vesicular Arbuscular Mycorrhiza in the Mycoremediation of Heavy Toxic Metals From Soil. Int J LifeSc Bt Pharm Res 2, 2418-2431. Wu, F., Fu, Z., Liu, B., Mo, C., Chen, B., Corns, W., Liao, H., 2011. Health risk associated with dietary co-exposure to high levels of antimony and arsenic in the world's largest antimony mine area. Sci. Total Environ. 409, 3344-3351. Xiong, T., Austruy, A., Dappe, V., Leveque, T., Sobanska, S., Foucault, Y., Dumat, C., 2013. Phytotoxicity and bioaccessibility of metals for vegetables exposed to atmosphere fine particles in polluted urban areas". Urban Environmental Pollution, Asian Edition, 17-20, Beijing, China.

  5. Hydrochromic Approaches to Mapping Human Sweat Pores.

    Science.gov (United States)

    Park, Dong-Hoon; Park, Bum Jun; Kim, Jong-Man

    2016-06-21

    colorimetric change near body temperature. This feature enables the use of this technique to generate high-quality images of sweat pores. This Account also focuses on the results of the most recent phase of this investigation, which led to the development of a simple yet efficient and reliable technique for sweat pore mapping. The method utilizes a hydrophilic polymer composite film containing fluorescein, a commercially available dye that undergoes a fluorometric response as a result of water-dependent interconversion between its ring-closed spirolactone (nonfluorescent) and ring-opened fluorone (fluorescent) forms. Surface-modified carbon nanodots (CDs) have also been found to be efficient for hydrochromic mapping of human sweat pores. The results discovered by Lou et al. [ Adv. Mater. 2015 , 27 , 1389 ] are also included in this Account. Sweat pore maps obtained from fingertips using these materials were found to be useful for fingerprint analysis. In addition, this hydrochromism-based approach is sufficiently sensitive to enable differentiation between sweat-secreting active pores and inactive pores. As a result, the techniques can be applied to clinical diagnosis of malfunctioning sweat pores. The directions that future research in this area will follow are also discussed. PMID:27159417

  6. Colored ultra-thin hybrid photovoltaics with high quantum efficiency for decorative PV applications (Presentation Recording)

    Science.gov (United States)

    Guo, L. Jay

    2015-10-01

    adopted by other material systems as well. Based on these understandings, we have also developed colored perovskite PV by integrating an optical cavity with the perovskite semiconductors [4]. The principle and experimental results will be presented. 1. J. Y. Lee, K. T. Lee, S.Y. Seo, L. J. Guo, "Decorative power generating panels creating angle insensitive transmissive colors," Sci. Rep. 4, 4192, 2014. 2. K. T. Lee, J.Y. Lee, S.-Y. Seo, and L. J. Guo, "Colored ultra-thin hybrid photovoltaics with high quantum efficiency," Light: Science and Applications, 3, e215, 2014. 3. K. T. Lee, S.-Y. Seo, J.Y. Lee, and L. J. Guo, "Ultrathin metal-semiconductor-metal resonator for angle invariant visible band transmission filters," Appl. Phys. Lett. 104, 231112, (2014); and "Strong resonance effect in a lossy medium-based optical cavity for angle robust spectrum filters," Adv. Mater, 26, 6324-6328, 2014. 4. K. T. Lee, M. Fukuda, L. J. Guo, "Colored, see-through perovskite solar cells employing an optical cavity," Submitted, 2015

  7. EDITORIAL: Bioengineering nanotechnology: towards the clinic Bioengineering nanotechnology: towards the clinic

    Science.gov (United States)

    Zhao, Weian; Karp, Jeffrey M.; Ferrari, Mauro; Serda, Rita

    2011-12-01

    special issue highlights some of the most recent advances in the exciting field of bioengineering nanotechnology. The themes covered in this issue include nanoparticle systems for tracking transplanted stem cells using a variety of imaging modalities, synthesis of smart nanomaterials for drug delivery and targeting specific intracellular organalles, elucidating how physical cues provided by nano- or micro-fabricated scaffolds impact cell phenotype, novel nanocomposite materials for biosensing, biomimetic assembly of nanostructures for studying molecular interactions, and high content analysis for assessing nanotoxicity. We believe next-generation nanomaterials that are currently under development will transform our understanding of biological mechanisms, and revolutionize clinical practice through ushering in new diagnostics and therapeutic paradigms. As nanotechnology becomes increasingly accessible to research laboratories, significant advances leading to paradigm shifts in basic biology and medicine will require connecting the right technology to the right problem and ensuring that the most pertinent criteria are correctly identified and addressed. References [1] Peer D et al Nat. Nanotechnol. 2 751-60 [2] Wang A Z, Langer R S and Farokhzad O C 2011 Annu. Rev. Med. doi: 10.1146/annurev-med-040210-162544 [3] Farokhzad O C and Langer R 2006 Adv. Drug Deliv. Rev. 58 1456-9 [4] Zhao W and Karp J M 2009 Nat. Mater. 8 453-4 [5] Ferreira L, Karp J M, Nobre L and Langer R 2008 Cell Stem Cell 3 136-46 [6] Zhao W and Karp J M 2009 ChemBioChem 10 2308-10 [7] Zhao W et al 2011 Nat. Nanotechnol. 6 524-31 [8] Stephan M T, Moon J J, Um S H, Bershteyn A and Irvine D J 2010 Nat. Med. 16 1035-41 [9] Sarkar D, Ankrum J A, Teo G S, Carman C V and Karp J M 2011 Biomaterials 32 3053-61

  8. Ad 2.0: a novel recombineering platform for high-throughput generation of tailored adenoviruses.

    Science.gov (United States)

    Mück-Häusl, Martin; Solanki, Manish; Zhang, Wenli; Ruzsics, Zsolt; Ehrhardt, Anja

    2015-04-30

    Recombinant adenoviruses containing a double-stranded DNA genome of 26-45 kb were broadly explored in basic virology, for vaccination purposes, for treatment of tumors based on oncolytic virotherapy, or simply as a tool for efficient gene transfer. However, the majority of recombinant adenoviral vectors (AdVs) is based on a small fraction of adenovirus types and their genetic modification. Recombineering techniques provide powerful tools for arbitrary engineering of recombinant DNA. Here, we adopted a seamless recombineering technology for high-throughput and arbitrary genetic engineering of recombinant adenoviral DNA molecules. Our cloning platform which also includes a novel recombination pipeline is based on bacterial artificial chromosomes (BACs). It enables generation of novel recombinant adenoviruses from different sources and switching between commonly used early generation AdVs and the last generation high-capacity AdVs lacking all viral coding sequences making them attractive candidates for clinical use. In combination with a novel recombination pipeline allowing cloning of AdVs containing large and complex transgenes and the possibility to generate arbitrary chimeric capsid-modified adenoviruses, these techniques allow generation of tailored AdVs with distinct features. Our technologies will pave the way toward broader applications of AdVs in molecular medicine including gene therapy and vaccination studies. PMID:25609697

  9. Development and validation of a novel hydrolysis probe real-time polymerase chain reaction for agamid adenovirus 1 in the central bearded dragon (Pogona vitticeps).

    Science.gov (United States)

    Fredholm, Daniel V; Coleman, James K; Childress, April L; Wellehan, James F X

    2015-03-01

    Agamid adenovirus 1 (AgAdv-1) is a significant cause of disease in bearded dragons (Pogona sp.). Clinical manifestations of AgAdv-1 infection are variable and often nonspecific; the manifestations range from lethargy, weight loss, and inappetence, to severe enteritis, hepatitis, and sudden death. Currently, diagnosis of AgAdv-1 infection is achieved through a single published method: standard nested polymerase chain reaction (nPCR) and sequencing. Standard nPCR with sequencing provides reliable sensitivity, specificity, and validation of PCR products. However, this process is comparatively expensive, laborious, and slow. Probe hybridization, as used in a TaqMan assay, represents the best option for validating PCR products aside from the time-consuming process of sequencing. This study developed a real-time PCR (qPCR) assay using a TaqMan probe-based assay, targeting a highly conserved region of the AgAdv-1 genome. Standard curves were generated, detection results were compared with the gold standard conventional PCR and sequencing assay, and limits of detection were determined. Additionally, the qPCR assay was run on samples known to be positive for AgAdv-1 and samples known to be positive for other adenoviruses. Based on the results of these evaluations, this assay allows for a less expensive, rapid, quantitative detection of AgAdv-1 in bearded dragons. PMID:25776549

  10. Prevalence of neutralising antibodies against adenoviruses in lizards and snakes.

    Science.gov (United States)

    Ball, Inna; Ofner, Sabine; Funk, Richard S; Griffin, Chris; Riedel, Ulf; Möhring, Jens; Marschang, Rachel E

    2014-10-01

    Adenoviruses (AdVs) are relatively common in lizards and snakes, and several genetically distinct AdVs have been isolated in cell culture. The aims of this study were to examine serological relationships among lizard and snake AdVs and to determine the frequency of AdV infections in these species. Isolates from a boa constrictor (Boa constrictor), a corn snake (Pantherophis gutattus) and a central bearded dragon (Pogona vitticeps), and two isolates from helodermatid lizards (Heloderma horridum and H. suspectum) were used in neutralisation tests for the detection of antibodies in plasma from 263 lizards from seven families (including 12 species) and from 141 snakes from four families (including 28 species) from the USA and Europe. Most lizard and snake samples had antibodies against a range of AdV isolates, indicating that AdV infection is common among these squamates. Neutralisation tests with polyclonal antibodies raised in rabbits demonstrated serological cross-reactivity between both helodermatid lizard isolates. However, squamate plasma showed different reactions to each of these lizard isolates in neutralisation tests. PMID:25163614

  11. The relationship between adenovirus-36 seropositivity, obesity and metabolic profile in Turkish children and adults.

    Science.gov (United States)

    Karamese, M; Altoparlak, U; Turgut, A; Aydogdu, S; Karamese, S Aksak

    2015-12-01

    Obesity potentially arising from viral infection is known as 'infectobesity'. The latest reports suggest that adenovirus-36 (Adv36) is related to obesity in adults and children. Our aim was not only to determine the Adv36 seropositivity in both obese and non-obese children and adults, but also to investigate correlations between antibody positivity and serum lipid profiles. Both Adv36 positivity and tumour-necrosis-factor-alpha, leptin and interleukin-6 levels were detected in blood samples collected from 146 children and 130 adults by ELISA. Fasting plasma triglycerides, total cholesterol and low-density lipoprotein levels were also measured. Adv36 positivity was determined to be 27·1% and 6% in obese and non-obese children and 17·5% and 4% in obese and non-obese adults, respectively. There was no difference with regard to total cholesterol, low-density lipoprotein, triglyceride, tumour-necrosis-factor-alpha and interleukin-6 levels (P > 0·05). However, there was a significant difference between groups in terms of leptin levels (P obese children and adults. Our results showed that Adv36 may be an obesity agent for both adults and children, parallel with current literature data. However, the available data on a possible relationship between Adv36 infection and obesity both in children and adults do not completely solve the problem.

  12. Development and validation of a novel hydrolysis probe real-time polymerase chain reaction for agamid adenovirus 1 in the central bearded dragon (Pogona vitticeps).

    Science.gov (United States)

    Fredholm, Daniel V; Coleman, James K; Childress, April L; Wellehan, James F X

    2015-03-01

    Agamid adenovirus 1 (AgAdv-1) is a significant cause of disease in bearded dragons (Pogona sp.). Clinical manifestations of AgAdv-1 infection are variable and often nonspecific; the manifestations range from lethargy, weight loss, and inappetence, to severe enteritis, hepatitis, and sudden death. Currently, diagnosis of AgAdv-1 infection is achieved through a single published method: standard nested polymerase chain reaction (nPCR) and sequencing. Standard nPCR with sequencing provides reliable sensitivity, specificity, and validation of PCR products. However, this process is comparatively expensive, laborious, and slow. Probe hybridization, as used in a TaqMan assay, represents the best option for validating PCR products aside from the time-consuming process of sequencing. This study developed a real-time PCR (qPCR) assay using a TaqMan probe-based assay, targeting a highly conserved region of the AgAdv-1 genome. Standard curves were generated, detection results were compared with the gold standard conventional PCR and sequencing assay, and limits of detection were determined. Additionally, the qPCR assay was run on samples known to be positive for AgAdv-1 and samples known to be positive for other adenoviruses. Based on the results of these evaluations, this assay allows for a less expensive, rapid, quantitative detection of AgAdv-1 in bearded dragons.

  13. Chemistry and Mineralogy of Antarctica Dry Valley Soils: Implications for Mars

    Science.gov (United States)

    Quinn, J. E.; Golden, D. C.; Graff, T. G.; Ming, D. W.; Morris, R. V.; Douglas, S.; Kounaves, S. P.; McKay, C. P.; Tamppari, L, K.; Smith, P. H.; Zent, A. P.; Archer, P. D., Jr.

    2011-01-01

    The Antarctic Dry Valleys (ADV) comprise the largest ice-free region of Antarctica. Precipitation almost always occurs as snow, relative humidity is frequently low, and mean annual temperatures are about -20 C. The ADV soils have previously been categorized into three soil moisture regimes: subxerous, xerous and ultraxerous, based on elevation and climate influences. The subxerous regime is predominately a coastal zone soil, and has the highest average temperature and precipitation, while the ultraxerous regime occurs at high elevation (>1000 m) and have very low temperature and precipitation. The amounts and types of salts present in the soils vary between regions. The nature, origin and significance of salts in the ADV have been previously investigated. Substantial work has focused on soil formation in the ADVs, however, little work has focused on the mineralogy of secondary alteration phases. The dominant weathering process in the ADV region is physical weathering, however, chemical weathering has been well documented. The objective of this study was to characterize the chemistry and mineralogy, including the alteration mineralogy, of soils from two sites, a subxerous soil in Taylor Valley, and an ultraxerous soil in University Valley. The style of aqueous alteration in the ADVs may have implications for pedogenic processes on Mars.

  14. Alfalfa dwarf cytorhabdovirus P protein is a local and systemic RNA silencing supressor which inhibits programmed RISC activity and prevents transitive amplification of RNA silencing.

    Science.gov (United States)

    Bejerman, Nicolás; Mann, Krin S; Dietzgen, Ralf G

    2016-09-15

    Plants employ RNA silencing as an innate defense mechanism against viruses. As a counter-defense, plant viruses have evolved to express RNA silencing suppressor proteins (RSS), which target one or more steps of the silencing pathway. In this study, we show that the phosphoprotein (P) encoded by the negative-sense RNA virus alfalfa dwarf virus (ADV), a species of the genus Cytorhabdovirus, family Rhabdoviridae, is a suppressor of RNA silencing. ADV P has a relatively weak local RSS activity, and does not prevent siRNA accumulation. On the other hand, ADV P strongly suppresses systemic RNA silencing, but does not interfere with the short-distance spread of silencing, which is consistent with its lack of inhibition of siRNA accumulation. The mechanism of suppression appears to involve ADV P binding to RNA-induced silencing complex proteins AGO1 and AGO4 as shown in protein-protein interaction assays when ectopically expressed. In planta, we demonstrate that ADV P likely functions by inhibiting miRNA-guided AGO1 cleavage and prevents transitive amplification by repressing the production of secondary siRNAs. As recently described for lettuce necrotic yellows cytorhabdovirus P, but in contrast to other viral RSS known to disrupt AGO activity, ADV P sequence does not contain any recognizable GW/WG or F-box motifs, which suggests that cytorhabdovirus P proteins may use alternative motifs to bind to AGO proteins. PMID:27543392

  15. Prevalence of neutralising antibodies against adenoviruses in lizards and snakes.

    Science.gov (United States)

    Ball, Inna; Ofner, Sabine; Funk, Richard S; Griffin, Chris; Riedel, Ulf; Möhring, Jens; Marschang, Rachel E

    2014-10-01

    Adenoviruses (AdVs) are relatively common in lizards and snakes, and several genetically distinct AdVs have been isolated in cell culture. The aims of this study were to examine serological relationships among lizard and snake AdVs and to determine the frequency of AdV infections in these species. Isolates from a boa constrictor (Boa constrictor), a corn snake (Pantherophis gutattus) and a central bearded dragon (Pogona vitticeps), and two isolates from helodermatid lizards (Heloderma horridum and H. suspectum) were used in neutralisation tests for the detection of antibodies in plasma from 263 lizards from seven families (including 12 species) and from 141 snakes from four families (including 28 species) from the USA and Europe. Most lizard and snake samples had antibodies against a range of AdV isolates, indicating that AdV infection is common among these squamates. Neutralisation tests with polyclonal antibodies raised in rabbits demonstrated serological cross-reactivity between both helodermatid lizard isolates. However, squamate plasma showed different reactions to each of these lizard isolates in neutralisation tests.

  16. DEPLETED URANIUM TECHNICAL WORK

    Science.gov (United States)

    The Depleted Uranium Technical Work is designed to convey available information and knowledge about depleted uranium to EPA Remedial Project Managers, On-Scene Coordinators, contractors, and other Agency managers involved with the remediation of sites contaminated with this mater...

  17. VISCOELASTIC PROPERTIES OF A BIOLOGICAL HYDROGEL PRODUCED FROM SOYBEAN OIL

    Science.gov (United States)

    Hydrogels formed from biopolymers or natural sources have special advantages because of their biodegradable and biocompatible properties. The viscoelastic properties of a newly developed biological hydrogel made from modified vegetable oil, epoxidized soybean oil (ESO) were investigated. The mater...

  18. Online Real-Time Tribology Failure Detection System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The investigation of the coating friction as a function of time is important to monitor the ball bearing heath. Despite the importance of the subject mater, there...

  19. EPILEPSY AND EDUCATION AND PREVENTION ACTIVITIES (EP) DATABASE

    Science.gov (United States)

    This database contains entries that focus on epilepsy education and prevention emphasizing the application of effective early detection and control program activities and risk reduction efforts. The database provides bibliographic citations and abstracts of various types of mater...

  20. Kristjan Järvi juhatab Pärdi maailmaesiettekannet Viinis / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2008-01-01

    Arvo Pärdi teose "Stabat Mater" segakoori- ja keelpilliorkestriversiooni maailmaesiettekandest 12. juunil Viinis ja dirigent Kristjan Järvi tegemistest. Bariton Lauri Vasar laulmas Hans Werner Henze ooperis "Phaedra" Berliinis, Brüsselis ja Viinis

  1. Novel Approach to the Dark Matter Problem: Primordial Intermediate-Mass Black Holes

    CERN Document Server

    Frampton, Paul H

    2016-01-01

    A discussion at a Scientific American level of the idea that the constituents of the dark mater in galactic halos are primordial intermediate-mass black holes with masses between ten and one hundred thousand times the solar mass.

  2. Stability of rotating supermassive stars in presence of dark matter background

    OpenAIRE

    Bisnovatyi-Kogan, G S

    1997-01-01

    Stability of supermassive stars embedded in hot dark matter is investigated on the base of the energetic method. Stability effect of dark mater is compared with rotational stabilization and preference of the last factor is advocated.

  3. Exercise physiologists: essential players in interdisciplinary teams for noncommunicable chronic disease management

    OpenAIRE

    Soan EJ; Street SJ; Brownie SM; Hills AP

    2014-01-01

    Esme J Soan,1–3 Steven J Street,1,2 Sharon M Brownie,3,4 Andrew P Hills1–31Mater Mothers' Hospital, South Brisbane, 2Mater Research Institute – University of Queensland, South Brisbane, 3Griffith Health Institute, Griffith University, Gold Coast, QLD, Australia; 4Green Templeton College, Oxford University, Oxford, UKAbstract: Noncommunicable diseases (NCDs), such as obesity and type 2 diabetes mellitus, are a growing public health challenge in Australia, ...

  4. Achievement of cardiovascular risk factor targets in young adults with diabetes mellitus

    OpenAIRE

    DONOVAN, PETER J.; H David McIntyre

    2010-01-01

    Peter J Donovan, H David McIntyreDepartment of Endocrinology, Mater Health Services, Mater Clinical School, The University of Queensland School of Medicine, South Brisbane, QLD, AustraliaBackground: Many patients with diabetes mellitus fail to achieve treatment targets recommended in recognized guidelines. Little data is available in this area relating to young adults.Objective: To assess whether treatment goals for glycosylated hemoglobin (HbA1c), blood pressure, lipid-lowering, and process ...

  5. Increased dendritic spine density and tau expression are associated with individual differences in steroidal regulation of male sexual behavior.

    Directory of Open Access Journals (Sweden)

    Pranay Bharadwaj

    Full Text Available Male sexual behavior (MSB is modulated by gonadal steroids, yet this relationship is highly variable across species and between individuals. A significant percentage (~30% of B6D2F1 hybrid male mice demonstrate MSB after long-term orchidectomy (herein after referred to as "maters", providing an opportunity to examine the mechanisms that underlie individual differences in steroidal regulation of MSB. Use of gene expression arrays comparing maters and non-maters has provided a first pass look at the genetic underpinnings of steroid-independent MSB. Surprisingly, of the ~500 genes in the medial preoptic area (MPOA that differed between maters and non-maters, no steroid hormone or receptor genes were differentially expressed between the two groups. Interestingly, best known for their association with Alzheimer's disease, amyloid precursor protein (APP and the microtubule-associated protein tau (MAPT were elevated in maters. Increased levels of their protein products (APP and tau in their non-pathological states have been implicated in cell survival, neuroprotection, and supporting synaptic integrity. Here we tested transgenic mice that overexpress tau and found facilitated mounting and intromission behavior after long-term orchidectomy relative to littermate controls. In addition, levels of synaptophysin and spinophilin, proteins generally enriched in synapses and dendritic spines respectively, were elevated in the MPOA of maters. Dendritic morphology was also assessed in Golgi-impregnated brains of orchidectomized B6D2F1 males, and hybrid maters exhibited greater dendritic spine density in MPOA neurons. In sum, we show for the first time that retention of MSB in the absence of steroids is correlated with morphological differences in neurons.

  6. Controlled light field concentration through turbid biological membrane for phototherapy

    OpenAIRE

    Wang, Fujuan; He, Hexiang; Zhuang, Huichang; Xie, Xiangsheng; Yang, Zhenchong; Cai, Zhigang; Gu, Huaiyu; Zhou, Jianying

    2015-01-01

    Laser propagation through a turbid rat dura mater membrane is shown to be controllable with a wavefront modulation technique. The scattered light field can be refocused into a target area behind the rat dura mater membrane with a 110 times intensity enhancement using a spatial light modulator. The efficient laser intensity concentration system is demonstrated to imitate the phototherapy for human brain tumors. The power density in the target area is enhanced more than 200 times compared with ...

  7. Investigation of enteric adenovirus and poliovirus removal by coagulation processes and suitability of bacteriophages MS2 and φX174 as surrogates for those viruses.

    Science.gov (United States)

    Shirasaki, N; Matsushita, T; Matsui, Y; Marubayashi, T; Murai, K

    2016-09-01

    We evaluated the removal of enteric adenovirus (AdV) type 40 and poliovirus (PV) type 1 by coagulation, using water samples from 13 water sources for drinking water treatment plants in Japan. The behaviors of two widely accepted enteric virus surrogates, bacteriophages MS2 and φX174, were compared with the behaviors of AdV and PV. Coagulation with polyaluminum chloride (PACl, basicity 1.5) removed AdV and PV from virus-spiked source waters: the infectious AdV and PV removal ratios evaluated by means of a plaque-forming-unit method were 0.1-1.4-log10 and 0.5-2.4-log10, respectively. A nonsulfated high-basicity PACl (basicity 2.1) removed infectious AdV and PV more efficiently than did other commercially available PACls (basicity 1.5-2.1), alum, and ferric chloride. The MS2 removal ratios tended to be larger than those of AdV and PV, partly because of differences in the hydrophobicities of the virus particles and the sensitivity of the virus to the virucidal activity of PACl; the differences in removal ratios were not due to differences in the surface charges of the virus particles. MS2, which was more hydrophobic than the other viruses, was inactivated during coagulation with PACl. Therefore, MS2 does not appear to be an appropriate surrogate for AdV and PV during coagulation. In contrast, because φX174, like AdV and PV, was not inactivated during coagulation, and because the hydrophobicity of φX174 was similar to or somewhat lower than the hydrophobicities of AdV and PV, the φX174 removal ratios tended to be similar to or somewhat smaller than those of the enteric viruses. Therefore, φX174 is a potential conservative surrogate for AdV and PV during coagulation. In summary, the surface hydrophobicity of virus particles and the sensitivity of the virus to the virucidal activity of the coagulant are probably important determinants of the efficiency of virus removal during coagulation.

  8. CONSORT: Effects of adding adefovirdipivoxil to peginterferon alfa-2a at different time points on HBeAg-positivepatients

    Science.gov (United States)

    Zhang, Ka; Cao, Hong; Liang, Jiayi; Shu, Xin; Sun, Haixia; Li, Gang; Xu, Qihuan

    2016-01-01

    Abstract Background: The aims of this study were to compare the efficacy and safety of the addition of adefovir dipivoxil (ADV) (started at different time points) to pegylated interferon alpha-2a (PEG-INF-α2a) and PEG-INF-α2a monotherapy. This prospective, randomized study sought to evaluate the safety and efficacy of the combination of PEG-INF-α2a and ADV at different time points.120 patients were randomized into groups that received PEG-INF-α2a as monotherapy (group A) or in combination with ADV started at week 0 (group B), 12 (group C), or 24 (group D). All patients were followed for 48 weeks. Efficacy and safety analyses were performed. Methods: Patients in group a received 135 μg of PEG-INF-α2a by subcutaneous injection once weekly for 48 weeks. Patients in the ADV add-on group received 135 μg of PEG-INF-α2a subcutaneously once weekly and received 10 mg of ADV administered once daily for 48 weeks. HBV DNA, HBsAg, HBeAg, and hepatitis B e antibody levels were determined. Responses were determined at week 12 (ADV add-on), the end of treatment for PEG-INF-α2a (48weeks) and ADV (EOT) and at the end of 96 weeks of follow-up (EOF). Results: The rate of HBV DNA loss were higher in the combination groups than group A at the week 12, week 48, the EOT and EOF (P 0.05). The alanineaminotransferase (ALT) normalization rate was higher in the combination group than group A only at the EOT (P = 0.007). By the EOF, the patients with ADV added at week 12 achieved higher rates of HBV DNA loss (71.9%), HBeAg seroconversion (50.0%), HBsAg loss (15.6%), and ALT normalization (78.1%). Conclusions: PEG-INF-α2a plus ADV combination therapy is safe and superior to PEG-INF-α2amonotherapyfor decreasing serum HBV DNA and normalizing the ALT level but has no significant impact on the rate of HBeAg seroconversion and HBsAg loss. Adding ADV at week 12 may be an optimal combination strategy. PMID:27495085

  9. Current and future disease progression of the chronic HCV population in the United States.

    Science.gov (United States)

    Zalesak, Martin; Francis, Kevin; Gedeon, Alex; Gillis, John; Hvidsten, Kyle; Kidder, Phyllis; Li, Hong; Martyn, Derek; Orne, Leslie; Smith, Amanda; Kwong, Ann

    2013-01-01

    Chronic hepatitis C virus (HCV) infection can lead to advanced liver disease (AdvLD), including cirrhosis, decompensated cirrhosis, and liver cancer. The aim of this study was to determine recent historical rates of HCV patient progression to AdvLD and to project AdvLD prevalence through 2015. We first determined total 2008 US chronic HCV prevalence from the National Health and Nutrition Evaluation Surveys. Next, we examined disease progression and associated non-pharmacological costs of diagnosed chronic HCV-infected patients between 2007-2009 in the IMS LifeLink and CMS Medicare claims databases. A projection model was developed to estimate AdvLD population growth through 2015 in patients diagnosed and undiagnosed as of 2008, using the 2007-2009 progression rates to generate a "worst case" projection of the HCV-related AdvLD population (i.e., scenario where HCV treatment is the same in the forecasted period as it was before 2009). We found that the total diagnosed chronic HCV population grew from 983,000 to 1.19 million in 2007-2009, with patients born from 1945-1964 accounting for 75.0% of all patients, 83.7% of AdvLD patients, and 79.2% of costs in 2009, indicating that HCV is primarily a disease of the "baby boomer" population. Non-pharmacological costs grew from $7.22 billion to $8.63 billion, with the majority of growth derived from the 60,000 new patients that developed AdvLD in 2007-2009, 91.5% of whom were born between 1945 and 1964. The projection model estimated the total AdvLD population would grow from 195,000 in 2008 to 601,000 in 2015, with 73.5% of new AdvLD cases from patients undiagnosed as of 2008. AdvLD prevalence in patients diagnosed as of 2008 was projected to grow 6.5% annually to 303,000 patients in 2015. These findings suggest that strategies to diagnose and treat HCV-infected patients are urgently needed to increase the likelihood that progression is interrupted, particularly for patients born from 1945-1964.

  10. Antiviral activity of Plantago major extracts and related compounds in vitro.

    Science.gov (United States)

    Chiang, L C; Chiang, W; Chang, M Y; Ng, L T; Lin, C C

    2002-07-01

    Plantago major L., a popular traditional Chinese medicine, has long been used for treating various diseases varying from cold to viral hepatitis. The aim of present study was to examine the antiviral activity of aqueous extract and pure compounds of P. major. Studies were conducted on a series of viruses, namely herpesviruses (HSV-1, HSV-2) and adenoviruses (ADV-3, ADV-8, ADV-11). The antiviral activity of EC50 was defined as the concentration achieved 50% cyto-protection against virus infection and the selectivity index (SI) was determined by the ratio of CC50 (concentration of 50% cellular cytotoxicity) to EC50. Results showed that aqueous extract of P. major possessed only a slight anti-herpes virus activity. In contrast, certain pure compounds belonging to the five different classes of chemicals found in extracts of this plant exhibited potent antiviral activity. Among them, caffeic acid exhibited the strongest activity against HSV-1 (EC50=15.3 microg/ml, SI=671), HSV-2 (EC50=87.3 microg/ml, SI=118) and ADV-3 (EC50=14.2 microg/ml, SI=727), whereas chlorogenic acid possessed the strongest anti-ADV-11 (EC50=13.3 microg/ml, SI=301) activity. The present study concludes that pure compounds of P. major, which possess antiviral activities are mainly derived from the phenolic compounds, especially caffeic acid. Its mode of action against HSV-2 and ADV-3 was found to be at multiplication stages (postinfection of HSV-1: 0-12 h; ADV-3: 0-2 h), and with SI values greater than 400, suggesting the potential use of this compound for treatment of the infection by these two viruses.

  11. Scavenging dissolved oxygen via acoustic droplet vaporization.

    Science.gov (United States)

    Radhakrishnan, Kirthi; Holland, Christy K; Haworth, Kevin J

    2016-07-01

    Acoustic droplet vaporization (ADV) of perfluorocarbon emulsions has been explored for diagnostic and therapeutic applications. Previous studies have demonstrated that vaporization of a liquid droplet results in a gas microbubble with a diameter 5-6 times larger than the initial droplet diameter. The expansion factor can increase to a factor of 10 in gassy fluids as a result of air diffusing from the surrounding fluid into the microbubble. This study investigates the potential of this process to serve as an ultrasound-mediated gas scavenging technology. Perfluoropentane droplets diluted in phosphate-buffered saline (PBS) were insonified by a 2 MHz transducer at peak rarefactional pressures lower than and greater than the ADV pressure amplitude threshold in an in vitro flow phantom. The change in dissolved oxygen (DO) of the PBS before and after ADV was measured. A numerical model of gas scavenging, based on conservation of mass and equal partial pressures of gases at equilibrium, was developed. At insonation pressures exceeding the ADV threshold, the DO of air-saturated PBS decreased with increasing insonation pressures, dropping as low as 25% of air saturation within 20s. The decrease in DO of the PBS during ADV was dependent on the volumetric size distribution of the droplets and the fraction of droplets transitioned during ultrasound exposure. Numerically predicted changes in DO from the model agreed with the experimentally measured DO, indicating that concentration gradients can explain this phenomenon. Using computationally modified droplet size distributions that would be suitable for in vivo applications, the DO of the PBS was found to decrease with increasing concentrations. This study demonstrates that ADV can significantly decrease the DO in an aqueous fluid, which may have direct therapeutic applications and should be considered for ADV-based diagnostic or therapeutic applications. PMID:26964964

  12. Identification of Human Adenovirus in Respiratory Samples with Luminex Respiratory Virus Panel Fast V2 Assay and Real-Time Polymerase Chain Reaction.

    Science.gov (United States)

    Esposito, Susanna; Scala, Alessia; Bianchini, Sonia; Zampiero, Alberto; Fossali, Emilio; Principi, Nicola

    2016-01-01

    In order to compare the last version of the Respiratory Virus Panel (RVP) Fast assay for human Adenovirus (hAdv) detection with a specific real-time polymerase chain reaction (qPCR), which is considered the gold standard for hAdv detection, nasopharyngeal samples collected from 309 children (age range, four months to eight years) with respiratory tract infection were tested using the RVP Fast v2 assay (Luminex Molecular Diagnostics, Inc., Toronto, ON, Canada) and a specific TaqMan qPCR to identify hAdv DNA. The RVP Fast v2 assay detected 30/61 (49.2%) hAdv infections that had been identified by real-time qPCR, demonstrating a significantly lower detection rate (p < 0.001). The sensitivity of the RVP Fast v2 assay in comparison to qPCR was lower in younger children (42.9% vs. 57.7%; Cohen's kappa coefficient, 0.53); in samples with co-infections (40.0% vs. 56.7%; Cohen's kappa coefficient, 0.52); and in samples with hAdv type C (45.9% vs. 57.1%; Cohen's kappa coefficient, 0.60). Samples with lower viral loads were associated with a significantly lower sensitivity of the RVP Fast v2 assay (35.1% vs. 68.2%, p = 0.01; Cohen's kappa coefficients, 0.49). The RVP Fast v2 assay has important limitations for the detection of hAdv and cannot be used to evaluate whether hAdvs are the main etiologic agent responsible for an outbreak or when epidemiological studies are performed. PMID:26927078

  13. EFFECTS OF IN VIVO GENE TRANSDUCTION OF ANTI-MDR1 RIBOZYME IN COMBINATION WITH CHEMOTHERAPY ON MULTIDRUG-RESISTANT HUMAN LYMPHOMA GROWTH IN MICE

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Objective: To study the effect of adenovirus- mediated transfer of anti-MDR1 ribozyme on the reversal of multidrug resistant (MDR) phenotype of P-glycoprotein (P-gp)-positive Daudi human Burkitt lymphoma both in vitro and in vivo. Methods: A recombinant adenovirus expressing 196Rz (Adv-196Rz) was developed and functionally evaluated. SCID mice inoculated subcutaneously (s.c.) with 5×106 Daudi/MDR20 cells were locally treated with Adv-196Rz or mock virus (Adv-Mock) at the multiplicity of infection (MOI) of 400 PFU once a day for 3 consecutive days. Then the mice were intraperitoneally (i.p.) administrated with vincristine (VCR) 450ng/g for 5 consecutive days. Results: In vitro employment of Adv-196Rz was able to interrupt MDR1 transcription, to inhibit P-gp expression and to restore drug sensitivity to VCR of Daudi/MDR20 cells. In vivo, 87.5% (7/8) of Daudi/MDR20-inoculated mice treated with Adv-Mock+ VCR developed palpable tumor by the 6th week and died or were sacrificed (because of tumor weight > 10% of body weight) by the 11th week. In contrast, among 9 Daudi/MDR20-inoculated mice treated with Adv-196Rz + VCR, only 3 developed tumor by the 11th, 13th and 14th week, respectively. 66.7% of mice survived >120 days in tumor-free. The survival difference between the two groups was very significant (P<0.01). Conclusion: Adenovirus- mediated Transfer of 196Rz can revert drug resistance of MDR tumor cells both in vitro and in vivo. Adv-196Rz may prove useful as an adjuvant in the chemotherapy of P-gp mediated MDR human tumors.

  14. 国外文献速报

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Hattel J H,Thorborg J,Pryds N H.液滴尺寸分布 对喷射成型过程气体温度的影响(英).Scr.mater.,1999,42(2):145~150 020306 Eden T J.喷射成型生产的铝合金(英).Ind.Heat,20 00,60(1):45~48 020307 Suzzani R.铸造工厂的快速成型的应用(意).Fonder ia,1999,48(11/12):48~51 020308 山村 英明,藤健 彦,原田宽.用铸型内电磁闸控制 夹杂物品质的最佳磁场强度(日).材料とぺロセス,2000,13(1):177 020309 比技 敏昭.使用注目素材的成型和金属型:镁合金 的射出成型技术和金属型(日).型技术,2000,15(2):30~35 020310 Froes F H,Ward-Close C M,Mccormick P G.轻金 属材料的合成及加工(英).Synth.Lightweight Met.,1999(3):3~11 020311 Matsuura K,Jinmon H,Kudou M.Ni-Al-Fe三元金 属间化合物合金的反应铸造(英).ISIJ Int.,2000,40(2):161~166 020312 Matsuura K,Jinmon H,Kudou M.利用反应铸造制造N iAl/被覆钢(英).ISIJ Int.,2000,40(2):167~171 020313 Meulenberg W A,Rothe H,Sahm P R.失蜡铸造陶瓷 壳型的制造和研究(英).Ceram.Forum.Int.,2000,77(4):30~35 020314 Nolte M.轻金属的砂型和重力金属型铸造(Ⅲ):熔 化、铸造、凝固(德).Giesseriei,2000,87(3):89~100 020315 Kaufman H,Uggowitzer P J,Wobussek H.关于NRC半 固态铸造工艺的冶金和加工(法).Hommes Fonderie,2000(303):36~40 020316 Goowin F,Garreau G H.氧使获得无气孔压铸件变为 可能(法).Hommes Fonderie,2000(303):34~35 生产设备及检测仪器仪表 020401 Rodriguez J M,Meza A.对铜管连续铸造中凝固前沿 控制的评注(英).J.Mater.Process Technol.,1999,96(1/3):42~47 020402 Poulsen E,Chinnis W,Mede M.钛的冷炉床熔炼技术 的进步(英).Ind.Heat,2000,67(1):49~51 020403 北冈 山治.最新铝溶液质量计测技术(日).铸造工学 ,2000,72(1):66~72 020404 Wu M,Augthun M,Sahm P R.用数值模拟联合快速成 形和失蜡铸造,钛假牙的相关结果(英).Adv.Eng.Mater.,2000,2(7):431

  15. The Efficacy of Add-on Telbivudine Versus Switching to Pegylated Interferon Alfa-2a in Chronic Hepatitis B Patients With Poor Responses to Adefovir

    Directory of Open Access Journals (Sweden)

    Wei

    2016-01-01

    Full Text Available Background There are limited options for chronic hepatitis B (CHB patients who have poor responses to adefovir (ADV. Objectives The aim of this study is to evaluate the effects of adding on telbivudine (LdT or switching to pegylated interferon alfa-2a (PEG-IFN-α2a as alternative rescue therapies for patients with poor responses to the initial ADV treatments. Patients and Methods Ninety-seven CHB patients with HBV DNA > 2 log10 copies/mL 48 weeks after ADV monotherapy were included in this study. Fifty-nine of these patients were treated with a combination of LdT plus ADV (LdT + ADV daily, while thirty-eight patients were switched to PEG-IFN-α2a subcutaneous injections weekly for 48 weeks. Results Both rescue strategies were proven to be safe and the majority of patients tolerated the therapies well. LdT + ADV led to more rapid reductions in viral loads than PEG-IFN-α2a monotherapy, with 2.14 (LdT + ADV and 0.98 (PEG-IFN-α2a log10 copies/mL decreases 48 weeks after rescue treatments, respectively (P < 0.00001. The rates corresponding to virological and biochemical responses were also elevated in patients who received the LdT + ADV combination therapy at the end of the observation period (88.1 vs. 68.4% for virological response, P = 0.017; 83.3 vs. 47.2%, P = 0.00045. However, the decline in the hepatitis B surface antigen (HBsAg was more pronounced in PEG-IFN-α2a treated patients. Moreover, the cumulative rates of serological responses were higher in patients who switched to the PEG-IFN-α2a therapy. Conclusions Both add-on LdT and switching to PEG-IFN-α2a were satisfactory and optimal treatments for CHB patients with poor responses to ADV. Both rescue strategies resulted in significant reductions in serum viral load and ALT levels, and were associated with high rate of serological outcomes in our hospital.

  16. Analysis of evolution and virological characteristics of rtI233V mutations in the hepatitis B virus reverse transcriptase domain

    Directory of Open Access Journals (Sweden)

    Xiao-ling YE

    2015-04-01

    Full Text Available Objective To analyze the evolution of rtI233V mutation in the reverse transcriptase domain of hepatitis B virus (HBV and its association with adefovir dipivoxil (ADV resistance. Methods The rate of detection of rtI233V mutation in 9830 patients with chronic HBV infection was analyzed. HBV reverse transcriptase genes isolated from serial serum samples of two patients were amplified by nested PCR, and clonal sequencing (>20 clones/sample was performed to analyze the evolution of rtI233V mutations. The replica of pTriEx-HBV1.1 vectors harboring wild-type and mutant strains (rtI233V, rtN236T, rtI233V+rtN236T were respectively constructed and transiently transfected into HepG2 cells. Media containing serial concentrations of lamivudine (LAM, ADV, entecavir (ETV, or tenofovir (TDF were used to treat the cells. Then HBV DNA in the supernatants was quantitatively determined by real-time PCR in order to analyze HBV mutants' replication competence and phenotypic characteristics under the drug pressures. Results The detection rate of rtI233V mutation in 9830 nucleos(tide analogues-treated patients was 0.28% (28/9830, including 0.19% (19 patients with rtI233V individual mutation and 0.09% (9 patients with rtI233V mutation combining with rtN236T or other mutations. All of the patients had rtI233V had ADV exposure history: 16 (57.1% of them received ADV monotherapy for over six months, and 12(42.9% of them received ADV combined sequential therapy for over 12 months. Replication competence and phenotypic resistance analysis showed rtI233V and wild-type strains had similar viral replication competence, while rtN236T exhibited significantly lower replication competence compared with wild-type strains. rtI233V strains remained sensitive to LAM, ADV, ETV, and TDF and showed little influence on drug resistance when combined with rtN236T, but it showed ability to restore the defected replication capacity of rtN236T strains. Conclusions  The rtI233V mutation

  17. The Evolution of Advanced Merger (U)LIRGs on the Color-Stellar Mass Diagram

    Science.gov (United States)

    Guo, Rui; Hao, Cai-Na; Xia, Xiao-Yang

    2016-08-01

    Based on a sample of 79 local advanced merger (adv-merger) (U)LIRGs, we search for evidence of quenching processes by investigating the distributions of star formation history indicators (EW(Hα), EW(HΔA) and Dn(4000)) on the NUV-r color-mass and SFR-M * diagrams. The distributions of EW(Hα) and Dn(4000) on the NUV-r color-mass diagram show clear trends that at a given stellar mass, galaxies with redder NUV-r colors have smaller EW(Hα) and larger D n (4000). The reddest adv-merger (U)LIRGs close to the green valley mostly have D n (4000)> 1.4. In addition, in the SFR-M * diagram, as the SFR decreases, the EW(Hα) decreases and the D n (4000) increases, implying that the adv-merger (U)LIRGs on the star formation main sequence have more evolved stellar populations than those above the main sequence. These results indicate that a fraction of the adv-merger (U)LIRGs have already exhibited signs of fading from the starburst phase and that the NUV-r reddest adv-merger (U)LIRGs are likely at the initial stage of post-starbursts with an age of ∼ 1 Gyr, which is consistent with the gas exhaustion time-scales. Therefore, our results offer additional support for the fast evolutionary track from the blue cloud to the red sequence.

  18. Characterization of deoxyribonucleic acid from cells infected with Aleutian disease virus

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, E.C.; Ramos, L.; Kenyon, A.J.

    1983-07-01

    Viral DNA was extracted from Crandell feline kidney (CRFK) cells infected with Aleutian disease virus (ADV) and labeled with (/sup 3/H)thymidine. The sedimentation coefficient in alkaline sucrose gradients was 16S corresponding to a molecular weight of 1.5 X 10(6). The buoyant densities of DNA from infected and control cells were determined by isopyknic sedimentation in CsCl and NaI gradients. Two additional peaks of (/sup 3/H)DNA were found in infected cells, but not in control cell extracts. Fractionation of this DNA on hydroxylapatite indicated that the new peaks represented a single-stranded component, density 1.728 g/cm3, and a double-stranded component, presumed to be a viral replicative intermediate, density 1.718 g/cm3. The target antigen formation in CRFK cells was measured by gamma-irradiation of ADV and assayed for focus formation. The calculated size of ADV based on these measurements was 1.1 X 10(6). The H-1 parvovirus also was shown to have a size of 1.5 X 10(6) daltons for both antigen and plaque formation. The data indicated similarities existed between ADV and other autonomously replicating parvoviruses in most properties, except that less-than-unit length genome of ADV may be transcribed.

  19. High-Density Superconducting Cables for Advanced ACTPol

    Science.gov (United States)

    Pappas, C. G.; Austermann, J.; Beall, J. A.; Duff, S. M.; Gallardo, P. A.; Grace, E.; Henderson, S. W.; Ho, S. P.; Koopman, B. J.; Li, D.; McMahon, J.; Nati, F.; Niemack, M. D.; Niraula, P.; Salatino, M.; Schillaci, A.; Schmitt, B. L.; Simon, S. M.; Staggs, S. T.; Stevens, J. R.; Vavagiakis, E. M.; Ward, J. T.; Wollack, E. J.

    2016-07-01

    Advanced ACTPol (AdvACT) is an upcoming Atacama Cosmology Telescope (ACT) receiver upgrade, scheduled to deploy in 2016, that will allow measurement of the cosmic microwave background polarization and temperature to the highest precision yet with ACT. The AdvACT increase in sensitivity is partly provided by an increase in the number of transition-edge sensors (TESes) per array by up to a factor of two over the current ACTPol receiver detector arrays. The high-density AdvACT TES arrays require 70 \\upmu m pitch superconducting flexible cables (flex) to connect the detector wafer to the first-stage readout electronics. Here, we present the flex fabrication process and test results. For the flex wiring layer, we use a 400-nm-thick sputtered aluminum film. In the center of the cable, the wiring is supported by a polyimide substrate, which smoothly transitions to a bare (uncoated with polyimide) silicon substrate at the ends of the cable for a robust wedge wire-bonding interface. Tests on the first batch of flex made for the first AdvACT array show that the flex will meet the requirements for AdvACT, with a superconducting critical current above 1 mA at 500 mK, resilience to mechanical and cryogenic stress, and a room temperature yield of 97 %.

  20. Binding sensitivity of adefovir to the polymerase from different genotypes of HBV: molecular modeling,docking and dynamics simulation studies

    Institute of Scientific and Technical Information of China (English)

    Jing LI; Yun DU; Xian LIU; Qian-cheng SHEN; Ai-long HUANG; Ming-yue ZHENG; Xiao-min LUO; Hua-liang JIANG

    2013-01-01

    Aim: To investigate the molecular mechanisms underlying the influence of DNA polymerase from different genotypes of hepatitis B virus (HBV) on the binding affinity of adefovir (ADV).Methods: Computational approaches,including homology modeling,docking,MD simulation and MM/PBSA free energy analyses were used.Results: Sequence analyses revealed that residue 238 near the binding pocket was not only a polymorphic site but also a genotypespecific site (His238 in genotype B; Asn238 in genotype C).The calculated binding free-energy supported the hypothesis that the polymerase from HBV genotype C was more sensitive to ADV than that from genotype B.By using MD simulation trajectory analysis,binding free energy decomposition and alanine scanning,some energy variation in the residues around the binding pocket was observed.Both the alanine mutations at residues 236 and 238 led to an increase of the energy difference between genotypes C and B (△△Gc-B),suggesting that these residues contributed to the genotype-associated antiviral variability with regard to the interaction with ADV.Conclusion: The results support the hypothesis that the HBV genotype C polymerase is more sensitive to ADV than that from genotype B.Moreover,residue N236 and the polymorphic site 238 play important roles in contributing to the higher sensitivity of genotype C over B in the interaction with ADV.

  1. Clinical and epidemiological aspects related to the detection of adenovirus or respiratory syncytial virus in infants hospitalized for acute lower respiratory tract infection

    Directory of Open Access Journals (Sweden)

    Eduardo A. Ferone

    2014-01-01

    Full Text Available OBJECTIVE: To characterize and compare clinical, epidemiological, and laboratory aspects ofinfants with acute lower respiratory infection (ALRI associated with the detection of adenovirus(ADV or respiratory syncytial virus (RSV. METHODS: A preliminary respiratory infection surveillance study collected samples of nasopharyngeal aspirate (NPA for viral research, linked to the completion of a standard protocol, from children younger than two years admitted to a university hospital with ALRI, between March of 2008 and August of 2011. Polymerase chain reaction (PCR was used for eight viruses: ADV, RSV, metapneumovirus, Parainfluenza 1, 2, and 3, and Influenza A and B. Cases with NPA collectedduring the first 24 hours of admission, negative results of blood culture, and exclusive detection of ADV (Gadv group or RSV (Grsv group were selected for comparisons. RESULTS: The preliminary study included collection of 1,121 samples of NPA, 813 collected in thefirst 24 hours of admission, of which 50.3% were positive for at least one virus; RSV was identifiedin 27.3% of cases surveyed, and ADV was identified in 15.8%. Among the aspects analyzed inthe Gadv (n = 58 and Grsv (n = 134 groups, the following are noteworthy: the higher meanage, more frequent prescription of antibiotics, and the highest median of total white blood cellcount and C-reactive protein values in Gadv. CONCLUSIONS: PCR can detect persistent/latent forms of ADV, an aspect to be considered wheninterpreting results. Additional studies with quantitative diagnostic techniques could elucidatethe importance of the high frequency observed.

  2. Sequence and expression analyses of the UL37 and UL38 genes of Aujeszky's disease virus.

    Science.gov (United States)

    Braun, A; Kaliman, A; Boldogköi, Z; Aszódi, A; Fodor, I

    2000-01-01

    Previously, we sequenced the HSV-1 Ul39-Ul40 homologue genes of Aujeszky's disease virus (ADV), also designated as pseudorabies virus (Kaliman et al., 1994a, b). Now we report the nucleotide sequence of the adjacent DNA that encodes Ul38, the 5'-region (750 bp) of Ul37, and the promoter regions between these divergently arranged two genes. The ADV Ul38 gene encodes a protein of 368 amino acids. Amino acid sequence comparison of ADV Ul38 with that of other herpesviruses revealed significant structural homology. In a transcription study using RNase protection assay and Northern blot hybridization, we found that the Ul38 gene had one initiation site, but the Ul37 gene was initiated at two transcription sites with two potential initiator AUGs, one of which was dominant. Comparison of ADV Ul37, Ul38 and ribonucleotide reductase gene expression showed that these genes belong to the same temporal class with early kinetics. Data of structural and transcriptional studies suggest that regulation of the expression of these two ADV genes could differ from that of the HSV-1 virus. PMID:11402671

  3. Treatment of murine tumors using acoustic droplet vaporization-enhanced high intensity focused ultrasound

    Science.gov (United States)

    Zhu, Meili; Jiang, Lixing; Fabiilli, Mario L.; Zhang, Aili; Fowlkes, J. Brian; Xu, Lisa X.

    2013-09-01

    High intensity focused ultrasound (HIFU) can be applied focally and noninvasively to thermally ablate solid tumors. Long treatment times are typically required for large tumors, which can expose patients to certain risks while potentially decreasing the therapeutic efficacy of the treatment. Acoustic droplet vaporization (ADV) is a promising modality that can enhance the efficacy of tumor treatment using HIFU. In this study, the therapeutic effects of combined HIFU and ADV was evaluated in mice bearing subcutaneously-implanted 4T1 tumors. Histological examination showed that the combination of HIFU and ADV generated a mean necrotic area in the tumor that was 2.9-fold larger than with HIFU alone. A significant enhancement of necrosis was found in the periphery of the tumor, where the blood supply was abundant. Seven days after treatment, the tumors treated with combined HIFU and ADV were 30-fold smaller in volume than tumors treated with HIFU alone. The study demonstrates the potential advantage of combining HIFU and ADV in tumor treatment.

  4. Characterization of Acoustic Droplet Vaporization Using MRI

    Science.gov (United States)

    Li, David; Allen, Steven; Hernandez-Garcia, Luis; Bull, Joseph

    2013-11-01

    Acoustic droplet vaporization (ADV) is the selective vaporization of liquid droplets to form larger gas bubbles. The ADV process is currently being researched for biomedical applications such as gas embolotherapy, drug delivery, and phase-change contrast agents. In this study an albumin encapsulated dodecafluoropentane (DDFP, CAS: 678-26-2) microdroplet suspension was vaporized using a single element focused (f/2, D = 19 mm) 3.5 MHz transducer (Panametrics A321S, Olympus, Waltham, MA). The resulting DDFP bubble clouds were imaged using both bright field microscopy and MRI (Varian 7T, Agilent Technologies Inc., Santa Clara, CA). Field distortions due to DDFP bubble generation were characterized against the bright field images as a function of acoustic power and bubble cloud size. Experimentally a direct correlation between bubble cloud dimensions generated and field distortions seen in the MRI was observed. Additionally, MR velocimetry was used to measure the flow field resulting from ADV. The field distortions due to the bubbles were further characterized by modeling Maxwell's equations using COMSOL (COMSOL Inc., Burlington, MA). The ability to characterize ADV with alternative imaging modalities may prove useful in further development of ADV based biomedical therapies.

  5. Mechanical Design and Development of TES Bolometer Detector Arrays for the Advanced ACTPol Experiment

    Science.gov (United States)

    Ward, Jonathan T.; Austermann, Jason; Beall, James A.; Choi, Steve K.; Crowley, Kevin T.; Devlin, Mark J.; Duff, Shannon M.; Gallardo, Patricio M.; Henderson, Shawn W.; Ho, Shuay-Pwu Patty; Hilton, Gene; Hubmayr, Johannes; Khavari, Niloufar; Klein, Jeffrey; Koopman, Brian J.; Li, Dale; McMahon, Jeffrey; Mumby, Grace; Nati, Federico; Wollack, Edward J.

    2016-01-01

    The next generation Advanced ACTPol (AdvACT) experiment is currently underway and will consist of four Transition Edge Sensor (TES) bolometer arrays, with three operating together, totaling 5800 detectors on the sky. Building on experience gained with the ACTPol detector arrays, AdvACT will utilize various new technologies, including 150 mm detector wafers equipped with multichroic pixels, allowing for a more densely packed focal plane. Each set of detectors includes a feedhorn array of stacked silicon wafers which form a spline pro le leading to each pixel. This is then followed by a waveguide interface plate, detector wafer, back short cavity plate, and backshort cap. Each array is housed in a custom designed structure manufactured from high purity copper and then gold plated. In addition to the detector array assembly, the array package also encloses cryogenic readout electronics. We present the full mechanical design of the AdvACT high frequency (HF) detector array package along with a detailed look at the detector array stack assemblies. This experiment will also make use of extensive hardware and software previously developed for ACT, which will be modi ed to incorporate the new AdvACT instruments. Therefore, we discuss the integration of all AdvACT arrays with pre-existing ACTPol infrastructure.

  6. Consumer Confidence and Elections

    OpenAIRE

    Hardouvelis, Gikas A; Dimitrios D. Thomakos

    2008-01-01

    We investigate the behavior of consumer confidence around national elections in the EU-15 countries during 1985:1-2007:3. Consumer confidence increases before the date of elections and falls subsequently by almost the same amount. It is able to predict the strength of the performance of the incumbent party and its probability of re-election both alone and in the presence of macro- economic and fiscal variables. The post-election drop is negatively related to the previous run up and is a funct...

  7. Affine and quasi-affine frames for rational dilations

    DEFF Research Database (Denmark)

    Bownik, Marcin; Lemvig, Jakob

    2011-01-01

    , the corresponding family of quasi-affine systems are frames with uniform frame bounds. We also prove a similar equivalence result between pairs of dual affine frames and dual quasi-affine frames. Finally, we uncover some fundamental differences between the integer and rational settings by exhibiting an example......In this paper we extend the investigation of quasi-affine systems, which were originally introduced by Ron and Shen [J. Funct. Anal. 148 (1997), 408-447] for integer, expansive dilations, to the class of rational, expansive dilations. We show that an affine system is a frame if, and only if...

  8. Low field anisotropic colossal magnetoresistance in $Sm_{0.53} Sr_{0.47} Mn O_3$ thin films

    OpenAIRE

    Manoj K. Srivastava; Singh, M P; Kaur, Amarjeet; Razavi, F. S.; Singh, H.K.

    2013-01-01

    SSMO5347 thin films (thicknesses ~200 nm) were deposited by on-axis dc magnetron sputtering on the single crystal LSAT (001) substrates. These films are oriented along the out of plane c-direction. The ferromagnetic and insulator-metal transition occurs at 96 K and 91 K, respectively. The magnetization easy axis is observed to lie in the plane of the film while the magnetic hard axis is found to be along the normal to this. The magnetotransport of the SSMO films, which was measured as a funct...

  9. m-Health smartphone applications on chronic disease monitoring : development and regulatory considerations

    OpenAIRE

    Li, Kit-ling, Carol; 李潔寧

    2014-01-01

    Introduction: The market for chronic disease management apps for patients is growing from year to year. However, policy and regulation of app use for medical purposes in Asia Pacific are not developed. Methods: 1) A systematic review of randomized-controlled trials of diabetes management apps for patients are assessed as to determine whether using the app (intervention group) leads to significant reductions in HbA1c levels ; 2) A comparison of paid and free apps based on number of group funct...

  10. On Some Expansion Theorems Involving Confluent Hypergeometric $_{2}F_{2}(x)$ Polynomial

    OpenAIRE

    Vyas, Yashoverdhan; Fatawat, Kalpana

    2016-01-01

    Recently, Rathie and K{\\i}l{\\i}\\c{c}man (2014) employed Kummer-type transformation for $_{2}F_{2}(a, d+1; b, d; x)$ to develop certain classes of expansions theorems for $_{2}F_{2}(x)$ hypergeometric polynomial. Our aim is to deduce Kummer-type transformation for $_{2}F_{2}(a, d+2; b, d; x)$ and utilize it to develop some new expansion theorems for the confluent hypergeometric $_{2}F_{2}(x)$ polynomial. We also obtain a well-known result given by Kim et al. (Integral Transforms Spec. Funct. 2...

  11. Cross-sectional associations between prevalent vertebral fracture and pulmonary function. The sixth Tromso Study

    OpenAIRE

    Morseth, Bente; Melbye, Hasse; Waterloo, Svanhild Haugnes; Thomassen, Marte Renate; Risberg, Marijke Jongsma; Emaus, Nina

    2013-01-01

    Background Persons with vertebral fracture may have reduced pulmonary function, but this association has not been much studied. The aim of this cross-sectional study was therefore to examine the relationship between vertebral fracture and pulmonary function in a general, elderly population. Methods Vertebral morphometry was used for vertebral fracture assessment in 2132 elderly men (n = 892) and women (n = 1240) aged 55 to 87 years in the population-based Tromsø Study 2007–08. Pulmonary funct...

  12. Predicting Nonresponse Bias from Teacher Ratings of Mental Health Problems in Primary School Children

    OpenAIRE

    Stormark, Kjell Morten; Heiervang, Einar; Heimann, Mikael; Lundervold, Astri; Gillberg, Christopher

    2008-01-01

    The impact of nonresponse on estimates of mental health problems was examined in a prospective teacher screen in a community survey of 9,155 7–9 year olds. For 6,611 of the children, parents consented to participation in the actual study (Responders), while for 2,544 children parental consent was not obtained (Nonresponders). The teacher screen involved assessment of a broad set of symptoms of mental health problems and functional impairment. Calculations of non-response coefficients, a funct...

  13. Localization lemmas for the Bergman metric at plurisubharmonic peak points

    OpenAIRE

    Herbort, Gregor

    2003-01-01

    Let $D$ be a bounded pseudoconvex domain in $\\CC^n$ and $\\zeta \\in \\d D$. By $K_D$ and $B_D$ we denote the Bergman kernel and metric of $D$, respectively. Given a ball $B=B(\\zeta, R)$, we study the behavior of the ratio $K_D/K_{D\\cap B} (w)$ when $w\\in D\\cap B$ tends towards $\\zeta$. It is well-known, that it remains bounded from above and below by a positive constant. We show, that the ratio tends to $1$, as $w$ tends to $\\zeta$, under an additional assumption on the pluricomplex Green funct...

  14. Towards precise calculation of transport coefficients in the hadron gas. The shear and the bulk viscosities

    OpenAIRE

    Moroz, Oleg N.

    2011-01-01

    The shear and the bulk viscosities of the hadron gas at low temperatures are studied in the model with constant elastic cross sections being relativistic generalization of the hard spheres model. One effective radius ${r=0.4 fm}$ is chosen for all elastic collisions. Only elastic collisions are considered which are supposed to be dominant at temperatures ${T\\leq 120-140 MeV}$. The calculations are done in the framework of the Boltzmann equation with the Boltzmann statistics distribution funct...

  15. Hacia una psicología social comunitaria

    OpenAIRE

    Gerardo Marín

    1980-01-01

    Either as a functíon of the críses in social psychology or as function of the needs for relevance in the area, contemporary social psychology is seen as moving into a "comunity social psychology". In this sense the ocial psychologist is ínterested in applying social-psychological knowledge in order to build from within thecommtinity. The role of the community social psychologist is seen as (a) measuring the community´s needs, (b) designíng the intervantíon that will produce ...

  16. Effect of Cardiac Rehabilitation Program on Exercise Capacity in Women Undergoing Coronary Artery Bypass Graft in Hamadan-Iran

    OpenAIRE

    Ramin Shabani; Abas A Gaeini; Nikoo, Mohamad R.; Hojatollah Nikbackt; Majid Sadegifar

    2010-01-01

    Objectives: The purpose of this study was to determine the effects of cardiac rehabilitation program (CRP) on exercise capacity and rate pressure product (RPP) in Iranian female patients undergoing coronary artery bypass grafting (CABG) in Hamadan, Iran. Methods: Sixty women after CABG were assigned into an exer-cise group (n = 30, mean age 58.5 ± 10.8 years), who performed physical training for 12 weeks, or a control group (n = 30, mean age 59.3 ± 8.6 years) who received usual care. Funct...

  17. Asymptotic Spreading Fastened by Inter-Specific Coupled Nonlinearities: a Cooperative System

    CERN Document Server

    Lin, Guo

    2010-01-01

    This paper is concerned with the asymptotic spreading of a Lotka-Volterra cooperative system. Utilizing the theory developed by Berestycki et al. [Asymptotic spreading in heterogeneous diffusive excitable media, J. Funct. Anal. \\textbf{255} (2008), 2146-2189] for nonautonomous scalar equations, the lower bounds of spreading speeds of unknown functions formulated by a coupled system are estimated. Our results imply that the asymptotic spreading of one species can be significantly fastened by introducing a mutual species, which indicates the role of cooperation described by the coupled nonlinearities.

  18. Trajectory analysis for the nucleus and dust of comet C/2013~A1 (Siding Spring)

    OpenAIRE

    Farnocchia, Davide; Chesley, Steven R.; Chodas, Paul W.; Tricarico, Pasquale; Kelley, Michael S. P.; Farnham, Tony L.

    2014-01-01

    Comet C/2013 A1 (siding Spring) will experience a high velocity encounter with Mars on October 19, 2014 at a distance of 135,000 km +- 5000 km from the planet center. We present a comprehensive analysis of the trajectory of both the comet nucleus and the dust tail. The nucleus of C/2013 A1 cannot impact on Mars even in the case of unexpectedly large nongravitational perturbations. Furthermore, we compute the required ejection velocities for the dust grains of the tail to reach Mars as a funct...

  19. Yeast Interacting Proteins Database: YLR446W, YLR211C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YLR446W - Putative protein of unknown function with similarity to hexokinases; tran...script is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene... Rows with this bait as bait (2) Rows with this bait as prey (0) YLR211C - Putative protein of unknown funct...ion; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR...as bait (0) 3 4 3 4 0 0 0 0 0 - - - - - 0 0 6 - Show YLR446W Bait ORF YLR446W Bait gene name - Bait descript

  20. High-resolution Imaging of pH in Alkaline Sediments and Water Based on a New Rapid Response Fluorescent Planar Optode

    OpenAIRE

    Han, Chao; Yao, Lei; Xu, Di; Xie, Xianchuan; Zhang, Chaosheng

    2016-01-01

    A new dual-lumophore optical sensor combined with a robust RGB referencing method was developed for two-dimensional (2D) pH imaging in alkaline sediments and water. The pH sensor film consisted of a proton-permeable polymer (PVC) in which two dyes with different pH sensitivities and emission colors: (1) chloro phenyl imino propenyl aniline (CPIPA) and (2) the coumarin dye Macrolex® fluorescence yellow 10 GN (MFY-10 GN) were entrapped. Calibration experiments revealed the typical sigmoid funct...

  1. Extrapolation from , vector-valued inequalities and applications in the Schrödinger settings

    Science.gov (United States)

    Tang, Lin

    2014-04-01

    In this paper, we generalize the A ∞ extrapolation theorem ( Cruz-Uribe-Martell-Pérez, Extrapolation from A ∞ weights and applications, J. Funct. Anal. 213 (2004), 412-439) and the A p extrapolation theorem of Rubio de Francia to Schrödinger settings. In addition, we also establish weighted vector-valued inequalities for Schrödinger-type maximal operators by using weights belonging to which includes A p . As applications, we establish weighted vector-valued inequalities for some Schrödinger-type operators.

  2. Effect of self-interstitial diffusion anisotropy in electron-irradiated zirconium: A cluster dynamics modeling

    Science.gov (United States)

    Christien, F.; Barbu, A.

    2005-11-01

    A model based on the cluster dynamics approach was proposed in [A. Hardouin Duparc, C. Moingeon, N. Smetniansky-de-Grande, A. Barbu, J. Nucl. Mater. 302 (2002) 143] to describe point defect agglomeration in metals under irradiation. This model is restricted to materials where point defect diffusion is isotropic and is thus not applicable to anisotropic metals such as zirconium. Following the approach proposed by Woo [C.H. Woo, J. Nucl. Mater. 159 (1988) 237], we extended in this work the model to the case where self-interstitial atoms (SIA) diffusion is anisotropic. The model was then applied to the loop microstructure evolution of a zirconium thin foil irradiated with electrons in a high-voltage microscope. First, the inputs were validated by comparing the numerical results with Hellio et al. experimental results [C. Hellio, C.H. de Novion, L. Boulanger, J. Nucl. Mater. 159 (1988) 368]. Further calculations were made to evidence the effect of the thin foil orientation on the dislocation loop microstructure under irradiation. The result is that it is possible to reproduce for certain orientations the 'unexpected' vacancy loop growth experimentally observed in electron-irradiated zirconium [M. Griffiths, M.H. Loretto, R.E. Sallmann, J. Nucl. Mater. 115 (1983) 313; J. Nucl. Mater. 115 (1983) 323; Philos. Mag. A 49 (1984) 613]. This effect is directly linked to SIA diffusion anisotropy.

  3. Effect of self-interstitial diffusion anisotropy in electron-irradiated zirconium: A cluster dynamics modeling

    Energy Technology Data Exchange (ETDEWEB)

    Christien, F. [Service de Recherches de Metallurgie Physique, CEA Saclay, 91191 Gif-sur-Yvette cedex (France)]. E-mail: frederic.christien@polytech.univ-nantes.fr; Barbu, A. [Service de Recherches de Metallurgie Physique, CEA Saclay, 91191 Gif-sur-Yvette cedex (France)

    2005-11-15

    A model based on the cluster dynamics approach was proposed in [A. Hardouin Duparc, C. Moingeon, N. Smetniansky-de-Grande, A. Barbu, J. Nucl. Mater. 302 (2002) 143] to describe point defect agglomeration in metals under irradiation. This model is restricted to materials where point defect diffusion is isotropic and is thus not applicable to anisotropic metals such as zirconium. Following the approach proposed by Woo [C.H. Woo, J. Nucl. Mater. 159 (1988) 237], we extended in this work the model to the case where self-interstitial atoms (SIA) diffusion is anisotropic. The model was then applied to the loop microstructure evolution of a zirconium thin foil irradiated with electrons in a high-voltage microscope. First, the inputs were validated by comparing the numerical results with Hellio et al. experimental results [C. Hellio, C.H. de Novion, L. Boulanger, J. Nucl. Mater. 159 (1988) 368]. Further calculations were made to evidence the effect of the thin foil orientation on the dislocation loop microstructure under irradiation. The result is that it is possible to reproduce for certain orientations the 'unexpected' vacancy loop growth experimentally observed in electron-irradiated zirconium [M. Griffiths, M.H. Loretto, R.E. Sallmann, J. Nucl. Mater. 115 (1983) 313; J. Nucl. Mater. 115 (1983) 323; Philos. Mag. A 49 (1984) 613]. This effect is directly linked to SIA diffusion anisotropy.

  4. Central nervous system consequences of an unusual body disposal strategy: case report and brief experimental investigation.

    Science.gov (United States)

    Andrews, John M; Gutstadt, Jeffrey P; Itabashi, Hideo H; Dowell, Steven J; Schuchardt, Mark S; Miller, Elizabeth A

    2003-09-01

    The body of a 73-year-old man was dismembered by his female companion for the purpose of covert disposal. The method employed included skillful separation of body parts with hacksaw and knife, piecemeal disposal of fragments, and prolonged boiling of the decapitated head. The latter treatment resulted in marked shrinkage of cranial dura mater, separation of dura mater from skull, and extrusion of brain fragments into the resultant enlarged epidural space through a dural defect due to the disproportionately greater shrinkage of dura mater compared to brain parenchyma. This resulted in curd-like brain fragments filling an enlarged epidural space and overlying a shrunken, leathery dura mater. The cranial dura mater, still adherent to the skull base, resembled a "shrunken brain" in contour but contained only the remnants of brain tissue not already extruded through the dural defect. This unusual thermal artifact is rarely illustrated or mentioned in forensic literature. The development of this postmortem artifact likely requires the presence of a specific combination of conditions which must be, but apparently rarely are, simultaneously present. PMID:14535685

  5. Advanced Virgo

    CERN Multimedia

    Virgo, a first-generation interferometric gravitational wave (GW) detector, located in the European Gravitational Observatory, EGO, Cascina (Pisa-Italy) and constructed by the collaboration of French and Italian institutes (CNRS and INFN) has successfully completed its long-duration data taking runs. It is now undergoing a fundamental upgrade that exploits available cutting edges technology to open an exciting new window on the universe, with the first detection of a gravitational wave signal. Advanced Virgo (AdV) is the project to upgrade the Virgo detector to a second-generation instrument. AdV will be able to scan a volume of the Universe 1000 times larger than initial Virgo. AdV will be hosted in the same infrastructures as Virgo. The Advanced VIRGO project is funded and at present carried on by a larger collaboration of institutes belonging to CNRS- France , RMKI - Hungary, INFN- Italy, Nikhef - The Netherlands Polish Academy of Science - Poland.

  6. Mechanical design and development of TES bolometer detector arrays for the Advanced ACTPol experiment

    CERN Document Server

    Ward, Jonathan T; Beall, James A; Choi, Steve K; Crowley, Kevin T; Devlin, Mark J; Duff, Shannon M; Gallardo, Patricio M; Henderson, Shawn W; Ho, Shuay-Pwu Patty; Hilton, Gene; Hubmayr, Johannes; Khavari, Niloufar; Klein, Jeffrey; Koopman, Brian J; Li, Dale; McMahon, Jeffrey; Mumby, Grace; Nati, Federico; Niemack, Michael D; Page, Lyman A; Salatino, Maria; Schillaci, Alessandro; Schmitt, Benjamin L; Simon, Sara M; Staggs, Suzanne T; Thornton, Robert; Ullom, Joel N; Vavagiakis, Eve M; Wollack, Edward J

    2016-01-01

    The next generation Advanced ACTPol (AdvACT) experiment is currently underway and will consist of four Transition Edge Sensor (TES) bolometer arrays, with three operating together, totaling ~5800 detectors on the sky. Building on experience gained with the ACTPol detector arrays, AdvACT will utilize various new technologies, including 150mm detector wafers equipped with multichroic pixels, allowing for a more densely packed focal plane. Each set of detectors includes a feedhorn array of stacked silicon wafers which form a spline profile leading to each pixel. This is then followed by a waveguide interface plate, detector wafer, back short cavity plate, and backshort cap. Each array is housed in a custom designed structure manufactured from high purity copper and then gold plated. In addition to the detector array assembly, the array package also encloses cryogenic readout electronics. We present the full mechanical design of the AdvACT high frequency (HF) detector array package along with a detailed look at t...

  7. Random sampling of the Central European bat fauna reveals the existence of numerous hitherto unknown adenoviruses.

    Science.gov (United States)

    Vidovszky, Márton; Kohl, Claudia; Boldogh, Sándor; Görföl, Tamás; Wibbelt, Gudrun; Kurth, Andreas; Harrach, Balázs

    2015-12-01

    From over 1250 extant species of the order Chiroptera, 25 and 28 are known to occur in Germany and Hungary, respectively. Close to 350 samples originating from 28 bat species (17 from Germany, 27 from Hungary) were screened for the presence of adenoviruses (AdVs) using a nested PCR that targets the DNA polymerase gene of AdVs. An additional PCR was designed and applied to amplify a fragment from the gene encoding the IVa2 protein of mastadenoviruses. All German samples originated from organs of bats found moribund or dead. The Hungarian samples were excrements collected from colonies of known bat species, throat or rectal swab samples, taken from live individuals that had been captured for faunistic surveys and migration studies, as well as internal organs of dead specimens. Overall, 51 samples (14.73%) were found positive. We detected 28 seemingly novel and six previously described bat AdVs by sequencing the PCR products. The positivity rate was the highest among the guano samples of bat colonies. In phylogeny reconstructions, the AdVs detected in bats clustered roughly, but not perfectly, according to the hosts' families (Vespertilionidae, Rhinolophidae, Hipposideridae, Phyllostomidae and Pteropodidae). In a few cases, identical sequences were derived from animals of closely related species. On the other hand, some bat species proved to harbour more than one type of AdV. The high prevalence of infection and the large number of chiropteran species worldwide make us hypothesise that hundreds of different yet unknown AdV types might circulate in bats. PMID:26599097

  8. The Role of Major Gas-rich Mergers on the Evolution of Galaxies from the Blue Cloud to the Red Sequence

    Science.gov (United States)

    Guo, Rui; Hao, Cai-Na; Xia, X. Y.; Mao, Shude; Shi, Yong

    2016-07-01

    With the aim of exploring the fast evolutionary path from the blue cloud of star-forming galaxies to the red sequence of quiescent galaxies in the local universe, we select a local advanced merging infrared luminous and ultraluminous galaxy (adv-merger (U)LIRGs) sample and perform careful dust extinction corrections to investigate their positions in the star formation rate-M *, u - r, and NUV - r color-mass diagrams. The sample consists of 89 (U)LIRGs at the late merger stage, obtained from cross-correlating the Infrared Astronomical Satellite Point Source Catalog Redshift Survey and 1 Jy ULIRGs samples with the Sloan Digital Sky Survey DR7 database. Our results show that 74 % +/- 5 % of adv-merger (U)LIRGs are localized above the 1σ line of the local star-forming galaxy main sequence. We also find that all adv-merger (U)LIRGs are more massive than and as blue as the blue cloud galaxies after corrections for Galactic and internal dust extinctions, with 95 % +/- 2 % and 81 % +/- 4 % of them outside the blue cloud on the u - r and NUV - r color-mass diagrams, respectively. These results, combined with the short timescale for exhausting the molecular gas reservoir in adv-merger (U)LIRGs (3× {10}7 to 3× {10}8 years), imply that the adv-merger (U)LIRGs are likely at the starting point of the fast evolutionary track previously proposed by several groups. While the number density of adv-merger (U)LIRGs is only ˜ 0.1 % of the blue cloud star-forming galaxies in the local universe, this evolutionary track may play a more important role at high redshift.

  9. Diffusion tensor imaging of the brain in patients with Alzheimer's disease and cerebrovascular lesions

    Institute of Scientific and Technical Information of China (English)

    CHEN Shao-qiong; KANG Zhuang; HU Xi-quan; HU Bing; ZOU Yan

    2007-01-01

    Background: Recent autopsy study showed a high incidence ofcerebrovascular lesions in Alzheimer's disease (AD).To assess the impact of cerebrovascular pathology in AD, we used diffusion tensor imaging (DTI) to study AD patients with and without cerebrovascular lesions. Materials and Methods: Conventional and DTI scans were obtained from 10 patients with probable AD, 10 AD/V patients (probable AD with cerebrovascular lesions) and ten normal controls. Mean diffusivity (D) and fractional anisotropy (FA) values of some structures involved with AD pathology were measured. Results: D value was higher in AD patients than in controls in hippocampus and the cingulate gyrus. In AD/V patients, increased D value was found in the same structures and also in the thalamus and basal ganglia compared to controls. There was a significant difference of D value between AD and AD/V patients. FA value reduced in the white matter of left inferior temporal gyrus and in the bilateral middle cingulate gyrus in patients with AD/V compared with controls. The MMSE (mini-mental state examination) score significantly correlated with FA value in the right hippocampus (r=0.639, P<0.019), in the right anterior cingulate gyrus (r=0.587, P<0.035) and in left parahippocampal gyrus (r=0.559, P<0.047). Conclusion: Cerebrovascular pathology had stronger impact on the D value than the AD pathology alone did. Elevated D value in thalamic and basal ganglia may contribute to cognitive decline in AD/V patients.Reduced FA values in AD/V patients may indicate that cerebrovascular pathology induced more severe white matter damage than the AD pathology alone did.

  10. In the rat liver, Adenoviral gene transfer efficiency is comparable to AAV.

    Science.gov (United States)

    Montenegro-Miranda, P S; Pichard, V; Aubert, D; Ten Bloemendaal, L; Duijst, S; de Waart, D R; Ferry, N; Bosma, P J

    2014-02-01

    Adenoviral (AdV) and Adenovirus-associated viral (AAV) vectors both are used for in vivo gene therapy of inherited liver disorders, such as Crigler-Najjar syndrome type 1. In a relevant animal model, the Gunn rat, both vectors efficiently correct the severe hyperbilirubinemia characteristic of this liver disorder. Although the clinical use of AAV is more advanced, as demonstrated by the successful phase 1 trial in hemophilia B patients, because of its large cloning capacity AdV remains an attractive option. A direct comparison of the efficacy of these two vectors in the liver in a relevant disease model has not been reported. Aim of this study was to compare the efficiency of clinically applicable doses of both vectors in the Gunn rat. AdV or scAAV (self-complimentary AAV) ferrying identical liver-specific expression cassettes of the therapeutic gene, UGT1A1, were injected into the tail vein. As the titration methods of these two vectors are very different, a comparison based on vector titers is not valid. Therefore, their efficacy was compared by determining the amount of vector genomes delivered to the liver required for therapeutic correction of serum bilirubin. Like AAV, the liver-specific first-generation AdV also provided sustained correction in this relevant disease model. UGT1A1 mRNA expression provided per genome was comparable for both vectors. Flanking the expression cassette in AdV with AAV-ITRs (inverted terminal repeats), increased UGT1A1 mRNA expression eightfold which resulted in a significant improvement of efficacy. Compared with AAV, less AdV genomes were needed for complete correction of hyperbilirubinemia.

  11. Cloning and expression of Aujeszky's disease virus glycoprotein E (gE) in a baculovirus system Clonagem e expressão da glicoproteina E (gE) do vírus da doença de Aujeszky em sistema de baculovirus

    OpenAIRE

    Régia Maria Feltrin Dambros; Bergman Moraes Ribeiro; Aguiar, Raimundo Wagner de S.; Rejane Schaefer; Paulo Augusto Esteves; Simone Perecmanis; Neide Lisiane Simon; Nayara Cavalcante Silva; Michele Coldebella; Janice Reis Ciacci-Zanella

    2007-01-01

    Aujeszky' s disease (AD) is an infectious disease causing important economic losses to the swine industry worldwide. The disease is caused by an alpha-herpesvirus, Aujeszky' s disease virus (ADV), an enveloped virus with a double stranded linear DNA genome. The ADV genome encodes 11 glycoproteins, which are major targets for the immune system of the host in response to the infection. The glycoprotein E (gE) is a non-essential protein and deletion of the gE gene has been used for the productio...

  12. 新目标英语七年级(下)Unit 11知识要点归纳

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    一、重点词汇milk v.挤奶cow n.奶牛horse n.马feed v.喂养;饲养farmer n.农民;农场主grow v.种植;生长;发育farm n.农场v.务农;种田pick v.采;摘excellent adj.极好的;优秀的countryside n.乡村;农村yesterday adv.昨天flower n.花worry v.&n.担心;担忧luckily adv.幸运地.

  13. High-level recombinant protein production in CHO cells using an adenoviral vector and the cumate gene-switch.

    Science.gov (United States)

    Gaillet, Bruno; Gilbert, Rénald; Amziani, Rachid; Guilbault, Claire; Gadoury, Christine; Caron, Antoine W; Mullick, Alaka; Garnier, Alain; Massie, Bernard

    2007-01-01

    To facilitate and accelerate the production of eukaryotic proteins with correct post-translational modifications, we have developed a protein production system based on the transduction of Chinese hamster ovary (CHO) cells using adenovirus vectors (AdVs). We have engineered a CHO cell line (CHO-cTA) that stably expresses the transactivator (cTA) of our newly developed cumate gene-switch transcription system. This cell line is adapted to suspension culture and can grow in serum-free and protein-free medium. To increase the transduction level of AdVs, we have also generated a cell line (CHO-cTA-CAR) that expresses additional amounts of the coxackievirus and adenovirus receptor (CAR) on its surface. Recombinant protein production was tested using an AdV carrying the secreted alkaline phosphatase (SEAP) under the control of the CR5 promoter, which is strongly and specifically activated by binding to cTA. The SEAP expression was linked to the expression of the green fluorescent protein (GFP) through an internal ribosome entry site (IRES) to facilitate titration of the AdV. We monitored SEAP expression on a daily basis for 9 days after transduction of CHO-cTA and CHO-cTA-CAR using different quantities of AdVs at 37 and 30 degrees C. Incubation at the latter temperature increased the production of SEAP at least 10-fold, and the presence of CAR increased the transduction level of the AdV. Maximum SEAP production (63 mg/L) was achieved at 6-7 days post-infection at 30 degrees C by transducing CHO-cTA-CAR with 500 infectious particles/cell. Because numerous AdVs can now be generated within a few weeks and large-scale production of AdVs is now a routine procedure, this system could be used to produce rapidly milligram quantities of a battery of recombinant proteins as well as for large-scale protein production.

  14. [Investigation of adenovirus isolation frequency from the stool samples of patients suspected with acute flaccid paralysis].

    Science.gov (United States)

    Bayrakdar, Fatma; Coşgun, Yasemin; Salman Atak, Tunca; Karademir, Hülya; Korukluoğlu, Gülay

    2016-04-01

    Although adenoviruses (AdVs) generally cause upper respiratory tract infections, conjunctivitis/epidemic keratoconjunctivitis, gastroenteritis and pneumonia, they can lead to the involvement of central nervous system. Acute flaccid paralysis (AFP) is a type of seizure, characterized by rapid and sudden onset of extreme weakness in hands and feet, including (less frequently) weakness of respiratory and swallowing, representing with decreased muscle tone, especially in children below 15-year-old. The major viral cause of AFP is polioviruses, however non-polio enteroviruses, mumps virus, rabies virus and flaviviruses can also be responsible for AFP. The data of some recent studies have pointed out the probable aetiological role of AdVs in AFP. The aim of this study was to investigate the frequency of AdVs from stool samples of AFP-suspected patients and their contacts. A total of 6130 stool samples from patients (age range: 0-15 years) prediagnosed as AFP (n= 3185) and their contacts (n= 2945), which were sent to our laboratory from the health care centers located at different regions of Turkey for the monitorization of poliomyelitis as part of national AFP surveillance programme, between 2000-2014, have been retrospectively evaluated in terms of adenovirus isolation frequency. Samples were analyzed according to the algorithm recommended by World Health Organization and inoculated in Hep-2, RD, and L20B cell lines for cultivation. Apart from enteroviruses, in case of the presence of characteristic cytopathic effects for AdVs observed in L20B cells were confirmed by a commercial Adeno agglutination kit (Diarlex Adeno; Orion Diagnostica, Finland). It was noted that AdVs have been isolated from 1.6% (97/6130) of the samples, and out of positive samples 76.3% (74/97) were from AFP-suspected cases, while 23.7% (23/97) were from their contacts. Accordingly the frequencies of AdVs from AFP-suspected cases and their contacts were found as 2.3% (74/3185) and 0.8% (23

  15. Assessing Photocatalytic Oxidation Using Modified TiO 2 Nanomaterials for Virus Inactivation in Drinking Water: Mechanisms and Application

    Science.gov (United States)

    Liga, Michael Vincent

    Photocatalytic oxidation is an alternative water treatment method under consideration for disinfecting water. Chlorine disinfection can form harmful byproducts, and some viruses (e.g. adenoviruses) are resistant to other alternative disinfection methods. Photocatalytic oxidation using nano-sized photocatalytic particles (e.g. TiO2, fullerene) holds promise; however, it is limited by its low efficiency and long required treatment times. This research focuses on improving virus inactivation by photocatalytic oxidation by modifying catalysts for improved activity, by analyzing virus inactivation kinetics, and by elucidating the inactivation mechanisms of adenovirus serotype 2 (AdV2) and bacteriophage MS2. Modifying TiO2 with silver (nAg/TiO2) or silica (SiO2-TiO2) improves the inactivation kinetics of bacteriophage MS2 by a factor of 3-10. nAg/ TiO2 increases hydroxyl radical (HO·) production while SiO2 increases the adsorption of MS2 to TiO 2. These results suggest that modifying the photocatalyst surface to increase contaminant adsorption is an important improvement strategy along with increasing HO· production. The inactivation kinetics of AdV2 by P25 TiO2 is much slower than the MS2 inactivation kinetics and displays a strong shoulder, which is not present in the MS2 kinetics. nAg/TiO2 initially improves the inactivation rate of AdV2. SiO2-TiO2 reduces the AdV2 inactivation kinetics since adsorption is not significantly enhanced, as it is with MS2. Amino-C60 is highly effective for AdV2 inactivation under visible light irradiation, making it a good material for use in solar disinfection systems. The efficacy of amino-fullerene also demonstrates that singlet oxygen is effective for AdV2 inactivation. When exposed to irradiated TiO2, AdV2 hexon proteins are heavily damaged resulting in the release of DNA. DNA damage is also present but may occur after capsids break. With MS2, the host interaction protein is rapidly damaged, but not the coat protein. The kinetics

  16. Inhibition of viral protein r on human colorectal cancer cells and the possible mechanisms%Vpr对人结肠癌细胞的抑制作用及其机制

    Institute of Scientific and Technical Information of China (English)

    马波; 张汉超; 徐新女; 张飚; 王金环

    2012-01-01

    Objective To investigate the inhibitive effects of viral protein r (Vpr) of human immunodeficiency virus 1 ( HIV-1 ) on human colorectal cancer cell line HCT-8,and to find the possible mechanisms.Methods The HCT-8 cells were divided into the control group,adv group and adv-Vpr group.HCT-8 cells were not treated in the control group; HCT-8 cells were treated with Adv or Adv-Vpr at different multiplicity of infection (MOI) in the Adv group or Adv-Vpr group,respectively.Cell proliferation was detected by MTT assay.Cell cycle,apoptosis and mitochondrial membrane potential were detected by flow cytometry.The expression of apoptosisrelated proteins was detected by Western blot.All data were analyzed by using the q test,t test and one-way or two-way analysis of variance.Results The proliferation of HCT-8 cells was significantly inhibited by Vpr.The MTT value of HCT- 8 cells in the Adv-Vpr group was 1.03 ± 0.04,which was significantly lower than 2.46 ± 0.15 in the Adv group and 2.51 ± 0.14 in the control group at 72 hours after Adv-Vpr transfection ( MOI =200) ( F =144.6,P < 0.05).The ratio of HCT-8 cells in the G2/M phase was 37.31% ± 5.90% in the Adv-Vpr group,which was significantly higher than 18.30% ± 6.04% in the Adv group and 16.66% ± 3.51% in the control group ( F =10.08,P < 0.05 ).The ratio of HCT-8 cells with decreased mitochondrial membrane potential was 32.07% ±5.64% in the Adv-Vpr group,which was significantly higher than 3.32% ±0.79% in the Adv group and 2.76% ±1.43 % in the control group at 48 hours after Adv-Vpr transfection ( MOI =200) ( F =64.45,P < 0.05).The apoptosis rate of HCT-8 cells was 37.62% ±6.48% in the Adv-Vpr group,which was significantly higher than 3.44% ± 1.11% in the Adv group and 2.93% ± 1.07% in the control group at 72 hours after Adv-Vpr transfection ( MOI =200) ( F =122.4,P < 0.05 ).The results of Western blot showed that Vpr induced cleavage and activation of Caspase-9 and

  17. Arachnoid granulations may control heat exchange between intracranial dural sinuses and cerebrospinal fluid

    Directory of Open Access Journals (Sweden)

    Abdullah Kaya

    2013-02-01

    Full Text Available Selective brain cooling is a system in a human that protects the brain from hyperthermia. Cool venous blood from head skin and upper respiratory tract drains into intracranial dural sinuses. In that region, cool blood in the dural sinuses decreases the temperature of the cerebrospinal fluid. Cerebrospinal fluid provides brain cooling. All cortical arteries to the brain pass the cerebrospinal fluid compartment. Also cerebrospinal fluid washes cortical nervous tissue. To provide optimal temperature for the brain cortex, heat exchange between cerebrospinal fluid and venous blood in dural sinuses should be well controlled. Head skin is in direct contact with the outside, and significant heat exchanges may occur within dural sinuses. A barrier made of dura mater and arachnoid mater has been proposed to transmit heat from dural sinuses to the cerebrospinal fluid. However, this barrier is a mechanical barrier and can’t optimize the temperature of cerebrospinal fluid. Also it has two laminas (dura mater and arachnoid mater and dura mater has a high vascularization. Therefore, this barrier may obstruct heat exchange. In this hypothetical paper, I offer arachnoid granulations as a functional barrier for heat exchange between blood in dural sinuses and cerebrospinal fluid. Arachnoid granulations are invaginations of arachnoid mater to the dural sinuses. Cerebrospinal fluid passes to the dural sinuses via arachnoid granulations. An arachnoid granulation provides a very thin wall between two compartments and may transmit heat effectively. Also arachnoid granulations may control cerebrospinal fluid flow to the dural sinuses according to temperature differences between two compartments. It is worth researching whether there are any functional or histological differences of the arachnoid granulations between people living in cold and hot places. There may also be an association between pathologies such as migraine and pseudotumor cerebri and this possible

  18. Desarrollo y caracterización de biocomposites enfibrados procedentes de recursos renovables. Estudio de su degradación en tierra

    OpenAIRE

    Moriana Torró, Rosana

    2010-01-01

    El propósito de la presente Tesis Doctoral es estudiar y predecir las características y la biodegradabilidad de diferentes biocomposites desarrollados a partir de materiales biodegradables procedentes de fuentes renovables. Para ello, se emplean dos termoplásticos de base almidón como matrices poliméricas (Mater-Bi KE03B1 y Mater-Bi NF01U ), que se refuerzan con distintas fibras naturales (algodón, cáñamo, kenaf, lino y yute) con el fin de mejorar sus propiedades mientras están en servicio, ...

  19. In situ staining of the primo vascular system in the ventricles and subarachnoid space of the brain by trypan blue injection into the lateral ventricle

    Institute of Scientific and Technical Information of China (English)

    Jingxing Dai; Byung-Cheon Lee; Ping An; Zhendong Su; Rongmei Qu; Ki Hoon Eom; Kwang-Sup Soh

    2011-01-01

    We examined a new method for visualization of the primo vascular system in the rat brain in-volving lateral ventricle injection of trypan blue. Results showed that the primo vascular system in the lateral ventricles and arachnoid mater of the brain were preferentially stained relative to blood vessels and fascia. The primo-vessels along blood vessels in the brain were clearly ex-hibited. In addition, the primo vascular system was evident between the fourth ventricle and the quadrigeminal cistern. Our experimental findings indicate that this new technique of lateral ventricle injection of trypan blue can visualize the primo vascular system in lateral ventricles and arachnoid mater of rats in situ.

  20. The Evolution of Advanced Merger (U)LIRGs on the Color-Stellar Mass Diagram

    CERN Document Server

    Guo, Rui; Xia, Xiao-Yang

    2016-01-01

    Based on a sample of 79 local advanced merger (adv-merger) (U)LIRGs, we search for the evidence of quenching process by investigating the distributions of the star formation history indicators (EW(H$\\alpha$), EW(H$\\delta$$_A$) and D$_n(4000)$) on the NUV-r color-mass and SFR-$M_{\\ast}$ diagrams. The distributions of the EW(H$\\alpha$) and D$_n(4000)$ on the NUV-r color-mass diagram show clear trends that at a given stellar mass, galaxies with redder NUV-r colors have smaller EW(H$\\alpha$) and larger D$_n(4000)$. The reddest adv-merger (U)LIRGs close to the green valley have D$_n(4000)$$>1.4$ mostly. In addition, in the SFR-$M_{\\ast}$ diagram, as the SFR decreases, the EW(H$\\alpha$) decreases and the D$_n(4000)$ increases, implying that the adv-merger (U)LIRGs on the star formation main sequence have more evolved stellar populations than those above the main sequence. These results indicate that a fraction of the adv-merger (U)LIRGs have already exhibited signs of fading from the starburst phase and that the NU...

  1. Avantages de l'emploi du magnésium forgé pour l'allègement des véhicules [ MagForge: Magnesium forged components for the automotive industry

    NARCIS (Netherlands)

    Chevaleyre, F.; Popescu, M.; Sillekens, W.H.; Ferreres, I.; Kurz, G.; Gourdin, P.; Gantar, G.

    2010-01-01

    This project, under 6th framework programme of the European Commission, aims to provide SME's with the cost-effective knowledge to provide the automotive industry with light forged magnesium-based alloys components. Low density, high mechanical properties and total recyclability pairing with the adv

  2. Informed Consent Obtainment, Malpractice Litigation, and the Potential Role of Shared Decision Making Approaches

    DEFF Research Database (Denmark)

    Birkeland, Søren

    2015-01-01

    (eg patient unawareness of intermittent adv. events, case 0658915). Findings confront the sometimes expressed opinion that patients just want the doctor to decide. Patients claim their right to DM participation and in many situations SDM DAs seem applicable. IC judgments may only display the tip...

  3. Functional consequences of iron deficiency in Chinese female workers.

    NARCIS (Netherlands)

    Li, R.

    1993-01-01

    Women of the reproductive age in China play a very important role in the labour force. Information on anaemia prevalence in this group is hardly available, notwithstanding the fact that iron deficiency anaemia is considered to be a major public health problem in China. Iron deficiency may cause adve

  4. Seroprevalence of Chlamydia abortus in camel in the western region of Libya

    Directory of Open Access Journals (Sweden)

    Rabia Elzlitne

    2016-06-01

    Conclusion: The present findings signify the C. abortus as a potential agent to cause abortion in Libyan camel (C. dromedarius. Besides, the persons who handle camels in Libya are at risk of infecting with C. abortus. [J Adv Vet Anim Res 2016; 3(2.000: 178-183

  5. Subcellular localization of Aleutian mink disease parvovirus proteins and DNA during permissive infection of Crandell feline kidney cells

    DEFF Research Database (Denmark)

    Oleksiewicz, M.B.; Costello, F.; Huhtanen, M.;

    1996-01-01

    Confocal microscopy allowed us to localize viral nonstructural (NS) and capsid (VP) proteins and DNA simultaneously in cells permissively infected with Aleutian mink disease parvovirus (ADV). Early after infection, NS proteins colocalized with viral DNA to form intranuclear inclusions, whereas VP...

  6. Two parvoviruses that cause different diseases in mink have different transcription patterns: Transcription analysis of mink enteritis virus and Aleutian mink disease parvovirus the same cell line

    DEFF Research Database (Denmark)

    Storgaard, T.; Oleksiewicz, M.; Bloom, M.E.;

    1997-01-01

    The two parvoviruses of mink cause very different diseases, Mink enteritis virus (MEV) is associated with rapid, high-level viral replication and acute disease, In contrast, infection with Aleutian mink disease parvovirus (ADV) is associated with persistent, low-level viral replication and chronic...

  7. Infectious risk factors for individual postweaning multisystemic wasting syndrome (PMWS) development in pigs from affected farms in Spain and Denmark

    DEFF Research Database (Denmark)

    Grau-Roma, Llorenç; Stockmarr, Anders; Kristensen, Charlotte S.;

    2012-01-01

    collected serum samples to detect antibodies against, PCV2, porcine reproductive and respiratory syndrome virus (PRRSV), porcine parvovirus (PPV), swine influenza virus (SIV) and Lawsonia intracellularis (law), Mycoplasma hyopneumoniae, Aujeszky’s disease virus (ADV) and Salmonella spp. A Cox proportional...

  8. Simulation of Climate Negotiation Strategies between China and the U.S. Based on Game Theory

    Directory of Open Access Journals (Sweden)

    Zhu-Gang Jin

    2014-01-01

    Citation: Jin, Z.-G., W.-J. Cai, and C. Wang, 2014: Simulation of climate negotiation strategies between China and the U.S. based on game theory.Adv. Clim. Change Res.,5(1, doi: 10.3724/SP.J.1248.2014.034.

  9. The efficiency of concentration methods used to detect enteric viruses in anaerobically digested sludge

    Directory of Open Access Journals (Sweden)

    Tatiana Prado

    2013-02-01

    Full Text Available The presence of enteric viruses in biosolids can be underestimated due to the inefficient methods (mainly molecular methods used to recover the viruses from these matrices. Therefore, the goal of this study was to evaluate the different methods used to recover adenoviruses (AdV, rotavirus species A (RVA, norovirus genogroup II (NoV GII and the hepatitis A virus (HAV from biosolid samples at a large urban wastewater treatment plant in Brazil after they had been treated by mesophilic anaerobic digestion. Quantitative polymerase chain reaction (PCR was used for spiking experiments to compare the detection limits of feasible methods, such as beef extract elution and ultracentrifugation. Tests were performed to detect the inhibition levels and the bacteriophage PP7 was used as an internal control. The results showed that the inhibitors affected the efficiency of the PCR reaction and that beef extract elution is a suitable method for detecting enteric viruses, mainly AdV from biosolid samples. All of the viral groups were detected in the biosolid samples: AdV (90%, RVA, NoV GII (45% and HAV (18%, indicating the viruses' resistance to the anaerobic treatment process. This is the first study in Brazil to detect the presence of RVA, AdV, NoV GII and HAV in anaerobically digested sludge, highlighting the importance of adequate waste management.

  10. In vitro cytotoxic, antiviral and immunomodulatory effects of Plantago major and Plantago asiatica.

    Science.gov (United States)

    Chiang, Lien-Chai; Chiang, Wen; Chang, Mei-Yin; Lin, Chun-Ching

    2003-01-01

    Plantago major linn. and P. asiatica Linn. (Plantaginaceae) are commonly used as folk medicine in Taiwan for treating infectious diseases related to the respiratory, urinary and digestive tracts. In this study, we investigated the antiviral, cytotoxic and immunomodulatory activities of hot water extracts of these two species in vitro on a series of viruses, namely herpesviruses (HSV-1 and HSV-2), adenoviruses (ADV-3, ADV-8 and ADV-11), and on various human leukemia, lymphoma and carcinoma cells with XTT, BrdU and IFN-gamma kits. Results showed that hot water extract of P. asiatica possessed significant inhibitory activity on the proliferation of lymphoma (U937) and carcinoma (bladder, bone, cervix, kidney, lung and stomach) cells and on viral infection (HSV-2 and ADV-11). P. major and P. asiatica both exhibited dual effects of immunodulatory activity, enhancing lymphocyte proliferation and secretion of interferon-gamma at low concentrations (effect at high concentration (> 50 microg/ml). The present study concludes that hot water extracts of P. major and P. asiatica possess abroad-spectrum of antileukemia, anticarcinoma and antiviral activities, as well as activities which modulate cell-mediated immunity. Further investigations to elucidate the active component(s) of P. asiatica and P. major and to evaluate their clinical application are warranted. PMID:12856861

  11. Pro-active environmental strategies,main source of competitive advantage within economic organizations

    OpenAIRE

    Oana-Catalina TÃPURICA; Florin TACHE

    2009-01-01

    Nowadays, contemporary organizations within Romanian economic environment are striving to reach the environmental and quality performance standards set up by the European Union, concerning the environmental protection and preservation. Under these circumstances, the organizations are highly recommended, especially those operating in high environmental impact economic sectors, to develop and implement proactive environmental strategies, as a main source to achieve a sustainable competitive adv...

  12. Where do intra-organizational advice relations come from? The role of informal status and social capital in social exchange

    NARCIS (Netherlands)

    Agneessens, Filip; Wittek, Rafael

    2012-01-01

    Social status and social capital frameworks are used to derive competing hypotheses about the emergence and structure of advice relations in organizations. Although both approaches build on a social exchange framework, they differ in their behavioral micro-foundations. From a status perspective, adv

  13. 一种精确求解两相流动的界面追踪方法

    Institute of Scientific and Technical Information of China (English)

    孙东亮; 王丽; 徐进良

    2011-01-01

    本文提出了一种求解两相流动问题的精确稳定的界面追踪方法-ADV-VOF(accurate density and viscosity volume of fluid method).该方法具有以下特征:(1)基于同位网格系统;(2)使用PLIC方法捕捉界面和计算网格边界上精确的密度和粘度值;(3)采用守恒的Navier-scokes方程,其中对流项离散格式为有界高阶组合格式--STOIC;(4)应用分步算法求解守恒的Naviel-Stokes方程;(5)利用Bi-CGSTAB方法求解压力修正方程.以上特征保证了ADV-VOF方法是一种精确、稳定、高效、简便的界面追踪方法.最后我们对ADV-VOF方法和传统的IDV-VOF(inaccurate demity and viscosity volume of fluid method)方法进行了比较分析,得出ADV-VOF方法的性能远远优于传统的IDV-VOF方法.

  14. Operator identities involving the bivariate Rogers-Szegö polynomials and their applications to the multiple q-series identities

    Science.gov (United States)

    Zhang, Zhizheng; Wang, Tianze

    2008-07-01

    In this paper, we first give several operator identities involving the bivariate Rogers-Szegö polynomials. By applying the technique of parameter augmentation to the multiple q-binomial theorems given by Milne [S.C. Milne, Balanced summation theorems for U(n) basic hypergeometric series, AdvE Math. 131 (1997) 93-187], we obtain several new multiple q-series identities involving the bivariate Rogers-Szegö polynomials. These include multiple extensions of Mehler's formula and Rogers's formula. Our U(n+1) generalizations are quite natural as they are also a direct and immediate consequence of their (often classical) known one-variable cases and Milne's fundamental theorem for An or U(n+1) basic hypergeometric series in Theorem 1E49 of [S.C. Milne, An elementary proof of the Macdonald identities for , Adv. Math. 57 (1985) 34-70], as rewritten in Lemma 7.3 on p. 163 of [S.C. Milne, Balanced summation theorems for U(n) basic hypergeometric series, Adv. Math. 131 (1997) 93-187] or Corollary 4.4 on pp. 768-769 of [S.C. Milne, M. Schlosser, A new An extension of Ramanujan's summation with applications to multilateral An series, Rocky Mountain J. Math. 32 (2002) 759-792].

  15. Mesenchymal Stem Cells : Promising for Myocardial Regeneration?

    NARCIS (Netherlands)

    Przybyt, Ewa; Harmsen, Martin C.

    2013-01-01

    The pandemic of cardiovascular disease is continuously expanding as the result of changing life styles and diets throughout the Old and New World. Immediate intervention therapy saves the lives of many patients after acute myocardial infarction (MI). However, for many this comes at the price of adve

  16. DMPD: Cytosolic DNA recognition for triggering innate immune responses. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18280611 Cytosolic DNA recognition for triggering innate immune responses. Takaoka ...A, Taniguchi T. Adv Drug Deliv Rev. 2008 Apr 29;60(7):847-57. Epub 2007 Dec 31. (.png) (.svg) (.html) (.csml) Show Cytosol...ic DNA recognition for triggering innate immune responses. PubmedID 18280611 Title Cytosolic D

  17. A Recombinant Adenovirus Expressing P12A and 3C Protein of the Type O Foot-and-Mouth Disease Virus Stimulates Systemic and Mucosal Immune Responses in Mice

    Science.gov (United States)

    Gao, Peng

    2016-01-01

    Foot-and-mouth disease (FMD) is a highly contagious livestock disease of cloven-hoofed animals which causes severe economic losses. The replication-deficient, human adenovirus-vectored FMD vaccine has been proven effective against FMD. However, the role of T-cell-mediated antiviral responses and the mucosae-mediated antiviral responses induced by the adenovirus-vectored FMD vaccine was rarely examined. Here, the capsid protein precursor P1-2A and viral protease 3C of the type O FMDV were expressed in replicative-deficient human adenovirus type 5 vector. BALB/c mice immunized intramuscularly and intraperitoneally with recombinant adenovirus rAdv-P12A3C elicited higher FMDV-specific IgG antibodies, IFN-γ, and IL-4 cytokines than those in mice immunized with inactivated FMDV vaccine. Moreover, BALB/c mice immunized with recombinant adenovirus rAdv-P12A3C by oral and intraocular-nasal immunization induced high FMDV-specific IgA antibodies. These results show that the recombinant adenovirus rAdv-P12A3C could resist FMDV comprehensively. This study highlights the potential of rAdv-P12A3C to serve as a type O FMDV vaccine. PMID:27478836

  18. Peer Influences on the Dating Aggression Process among Brazilian Street Youth: A Brief Report

    Science.gov (United States)

    Antonio, Tiago; Koller, Silvia H.; Hokoda, Audrey

    2012-01-01

    This study explored risk factors for adolescent dating aggression (ADA) among Brazilian street youth. Forty-three adolescents, between the ages of 13 and 17 years, were recruited at services centers in Porto Alegre, Brazil. Simultaneous multiple regression revealed that ADA was significantly predicted by adolescent dating victimization (ADV), and…

  19. Quality assessment of imported powder milk at Mansoura city, Egypt

    Directory of Open Access Journals (Sweden)

    Adel Abdelkhalek

    2016-03-01

    Conclusion: Based on the Egyptian Standards, the samples were satisfactory in terms of the association of Salmonella spp., E. coli, and fungi. Contamination with Staph. aureus warrans the public health. Thus, appropriate care and preventive measures are suggested. [J Adv Vet Anim Res 2016; 3(1.000: 75-78

  20. Random Sampling of Squamate Reptiles in Spanish Natural Reserves Reveals the Presence of Novel Adenoviruses in Lacertids (Family Lacertidae) and Worm Lizards (Amphisbaenia)

    Science.gov (United States)

    Szirovicza, Leonóra; López, Pilar; Kopena, Renáta; Benkő, Mária; Martín, José; Pénzes, Judit J.

    2016-01-01

    Here, we report the results of a large-scale PCR survey on the prevalence and diversity of adenoviruses (AdVs) in samples collected randomly from free-living reptiles. On the territories of the Guadarrama Mountains National Park in Central Spain and of the Chafarinas Islands in North Africa, cloacal swabs were taken from 318 specimens of eight native species representing five squamate reptilian families. The healthy-looking animals had been captured temporarily for physiological and ethological examinations, after which they were released. We found 22 AdV-positive samples in representatives of three species, all from Central Spain. Sequence analysis of the PCR products revealed the existence of three hitherto unknown AdVs in 11 Carpetane rock lizards (Iberolacerta cyreni), nine Iberian worm lizards (Blanus cinereus), and two Iberian green lizards (Lacerta schreiberi), respectively. Phylogeny inference showed every novel putative virus to be a member of the genus Atadenovirus. This is the very first description of the occurrence of AdVs in amphisbaenian and lacertid hosts. Unlike all squamate atadenoviruses examined previously, two of the novel putative AdVs had A+T rich DNA, a feature generally deemed to mirror previous host switch events. Our results shed new light on the diversity and evolution of atadenoviruses. PMID:27399970

  1. Chinese Public’s Willingness to Pay for CO2 Emissions Reductions: A Case Study from Four Provinces/Cities

    Directory of Open Access Journals (Sweden)

    Duan Hong-Xia

    2014-01-01

    Citation: Duan, H.-X., Lü, Y.-L., Li, Y., 2014. Chinese public’s willingness to pay for CO2 emissions reductions: A case study from four provinces/cities. Adv. Clim. Change Res. 5(2, doi: 10.3724/SP.J.1248.2014.100.

  2. Antibiotic resistance profile of bacteria isolated from raw milk samples of cattle and buffaloes

    Directory of Open Access Journals (Sweden)

    Tahlina Tanzin

    2016-03-01

    Conclusion: Two different species of bacteria i.e., S. aureus and E. coli are contaminating with milk samples. The pathogenic bacteria can be controlled effectively by using Ciprofloxacin and Levofloxacin in the case of mastitis in cattle and buffaloes in Bangladesh. [J Adv Vet Anim Res 2016; 3(1.000: 62-67

  3. A Multicenter, Open-label Study of CMX001 Treatment of Serious Diseases or Conditions Caused by dsDNA Viruses

    Science.gov (United States)

    2013-08-28

    Male or Female Patients With a Serious or Immediately Life-threatening; Disease or Condition Caused by CMV, ADV, HSV, VAVC, VARV or; Monkeypox Viruses(s) Who Have a Life Expectancy of ≥ 2 Weeks and for; Whom no Comparable or Satisfactory Alternative Therapy is Available

  4. Large inter-individual variation in isoflavone plasma concentration limits use of isoflavone intake data for risk assessement

    NARCIS (Netherlands)

    Velpen, van der V.; Hollman, P.C.H.; Nielen, van M.; Schouten, E.G.; Mensink, M.R.; Veer, van 't P.; Geelen, A.

    2014-01-01

    Background/objectives: Isoflavones are present in soy foods and soy-based supplements. Despite low plasma isoflavone concentrations in the general Western population, concentrations in supplement users exceed those suggested to be beneficial for health in Asian populations, raising concerns for adve

  5. A Recombinant Adenovirus Expressing P12A and 3C Protein of the Type O Foot-and-Mouth Disease Virus Stimulates Systemic and Mucosal Immune Responses in Mice.

    Science.gov (United States)

    Xie, Yinli; Gao, Peng; Li, Zhiyong

    2016-01-01

    Foot-and-mouth disease (FMD) is a highly contagious livestock disease of cloven-hoofed animals which causes severe economic losses. The replication-deficient, human adenovirus-vectored FMD vaccine has been proven effective against FMD. However, the role of T-cell-mediated antiviral responses and the mucosae-mediated antiviral responses induced by the adenovirus-vectored FMD vaccine was rarely examined. Here, the capsid protein precursor P1-2A and viral protease 3C of the type O FMDV were expressed in replicative-deficient human adenovirus type 5 vector. BALB/c mice immunized intramuscularly and intraperitoneally with recombinant adenovirus rAdv-P12A3C elicited higher FMDV-specific IgG antibodies, IFN-γ, and IL-4 cytokines than those in mice immunized with inactivated FMDV vaccine. Moreover, BALB/c mice immunized with recombinant adenovirus rAdv-P12A3C by oral and intraocular-nasal immunization induced high FMDV-specific IgA antibodies. These results show that the recombinant adenovirus rAdv-P12A3C could resist FMDV comprehensively. This study highlights the potential of rAdv-P12A3C to serve as a type O FMDV vaccine. PMID:27478836

  6. On the coevolution of social responsiveness and behavioural consistency

    NARCIS (Netherlands)

    Wolf, Max; Van Doorn, G. Sander; Weissing, Franz J.

    2011-01-01

    Recent research focuses on animal personalities, that is individual differences in behaviour that are consistent across contexts and over time. From an adaptive perspective, such limited behavioural plasticity is surprising, since a more flexible structure of behaviour should provide a selective adv

  7. Comprehension of grammatically modified and nonmodified sentences by second-language learners

    NARCIS (Netherlands)

    D.C. Issidorides; J.H. Hulstijn

    1992-01-01

    At issue in the present research is whether native speakers' "simplified" or modified utterances, as in foreigner-talk (FT), actually facilitate comprehension for nonnative speakers hearing such utterances. It was hypothesized that (grammatical) Dutch inversion sentences (AdvVSO) that have proven to

  8. Review of Decoherence Free Subspaces, Noiseless Subsystems, and Dynamical Decoupling

    OpenAIRE

    Lidar, Daniel A.

    2012-01-01

    Comment: 34 pages, 4 figures. Based on lecture notes from a course on quantum error correction given by the author at USC in Spring 2007 and Fall 2011, 2013. Prepared for a special issue of Adv. Chem. Phys. on Quantum Information and Computation for Chemistry. v3: some parts rewritten for clarity, various corrections

  9. Efficacy and safety of myocardial gene transfer of adenovirus, adeno-associated virus and lentivirus vectors in the mouse heart.

    Science.gov (United States)

    Merentie, M; Lottonen-Raikaslehto, L; Parviainen, V; Huusko, J; Pikkarainen, S; Mendel, M; Laham-Karam, N; Kärjä, V; Rissanen, R; Hedman, M; Ylä-Herttuala, S

    2016-03-01

    Gene therapy is a promising new treatment option for cardiac diseases. For finding the most suitable and safe vector for cardiac gene transfer, we delivered adenovirus (AdV), adeno-associated virus (AAV) and lentivirus (LeV) vectors into the mouse heart with sophisticated closed-chest echocardiography-guided intramyocardial injection method for comparing them with regards to transduction efficiency, myocardial damage, effects on the left ventricular function and electrocardiography (ECG). AdV had the highest transduction efficiency in cardiomyocytes followed by AAV2 and AAV9, and the lowest efficiency was seen with LeV. The local myocardial inflammation and fibrosis in the left ventricle (LV) was proportional to transduction efficiency. AdV caused LV dilatation and systolic dysfunction. Neither of the locally injected AAV serotypes impaired the LV systolic function, but AAV9 caused diastolic dysfunction to some extent. LeV did not affect the cardiac function. We also studied systemic delivery of AAV9, which led to transduction of cardiomyocytes throughout the myocardium. However, also diffuse fibrosis was present leading to significantly impaired LV systolic and diastolic function and pathological ECG changes. Compared with widely used AdV vector, AAV2, AAV9 and LeV were less effective in transducing cardiomyocytes but also less harmful. Local administration of AAV9 was safer and more efficient compared with systemic administration.

  10. Heavy metals precipitation in sewage sludge

    NARCIS (Netherlands)

    Marchioretto, M.M.; Rulkens, W.H.; Bruning, H.

    2005-01-01

    There is a great need for heavy metal removal from strongly metal-polluted sewage sludges. One of the advantages of heavy metal removal from this type of sludge is the possibility of the sludge disposal to landfill with reduced risk of metals being leached to the surface and groundwater. Another adv

  11. 77 FR 47471 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2012-08-08

    ... share price of $1.00 or more at the close. \\4\\ For purposes of SLP liquidity credits, ADV calculations... three credit rates would apply to SLPs: \\5\\ \\5\\ SLP execution of securities with a per share price of $1... Exchange in securities with a per share price of $1.00 or more, if the SLP does not qualify for the...

  12. Mineralogy of Antarctica Dry Valley Soils: Implications for Pedogenic Processes on Mars

    Science.gov (United States)

    Quinn, J. E.; Ming, D. W.; Morris, R. V.; Douglas, S.; Kounaves, S. P.; McKay, C. P.; Tamppari, L, K.; Smith, P. H.; Zent, A. P.; Archer, P. D., Jr.

    2010-01-01

    The Antarctic Dry Valleys (ADVs) located in the Transantarctic Mountains are the coldest and driest locations on Earth. The mean annual air temperature is -20 C or less and the ADVs receive 100mm or less of precipitation annually in the form of snow. The cold and dry climate in the ADVs is one of the best terrestrial analogs for the climatic conditions on Mars [2]. The soils in the ADVs have been categorized into three soil moisture zones: subxerous, xerous and ultraxerous. The subxerous zone is a coastal region in which soils have ice-cemented permafrost relatively close to the surface. Moisture is available in relatively large amounts and soil temperatures are above freezing throughout the soil profile (above ice permafrost) in summer months. The xerous zone, the most widespread of the three zones, is an inland region with a climate midway between the subxerous and ultraxerous. The soils from this zone have dry permafrost at moderate depths (30-75cm) but have sufficient water in the upper soil horizons to allow leaching of soluble materials. The ultraxerous zone is a high elevation zone, where both temperature and precipitation amounts are very low resulting in dry permafrost throughout the soil profile. The three moisture regime regions are similar to the three microclimatic zones (coastal thaw, inland mixed, stable upland) defined by Marchant and Head.

  13. Transportation scenario of Black Bengal goats in Gabtoli and Sirajganj markets of Bangladesh

    Directory of Open Access Journals (Sweden)

    Mohammed Nazmus sakib

    2016-03-01

    Conclusion: From this study it is concluded that Black Bengal goats became physically unfit during long time transportation although majority of the farmers took proper management practices. Therefore, changes in behavioral responses might be alleviated through creating awareness to animal raiser as well transporter. [J Adv Vet Anim Res 2016; 3(1.000: 38-44

  14. DMPD: Nucleic acid-sensing Toll-like receptors: beyond ligand search. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18321608 Nucleic acid-sensing Toll-like receptors: beyond ligand search. Miyake K. ...Adv Drug Deliv Rev. 2008 Apr 29;60(7):782-5. Epub 2008 Feb 15. (.png) (.svg) (.html) (.csml) Show Nucleic ac...id-sensing Toll-like receptors: beyond ligand search. PubmedID 18321608 Title Nucleic acid-sensing Toll-like

  15. Effects of viscosity on endothelial cell damage under acoustic droplet vaporization

    Science.gov (United States)

    Seda, Robinson; Singh, Rahul; Li, David; Pitre, John; Putnam, Andrew; Fowlkes, J. Brian; Bull, Joseph

    2014-11-01

    Acoustic droplet vaporization (ADV) is a process by which stabilized superheated microdroplets are able to undergo phase transition with the aid of focused ultrasound. Gas bubbles resulting from ADV can provide local occlusion of the blood vessels supplying diseased tissue, such as tumors. The ADV process can also induce bioeffects that increase vessel permeability, which is beneficial for localized drug delivery. Previous in vitro studies have demonstrated that vaporization at the endothelial layer will affect cell attachment and viability. Several hypotheses have been proposed to elucidate the mechanism of damage including the generation of normal and shear stresses during bubble expansion. A single 3.5 MHz ultrasound pulse consisting of 8 cycles (~2.3 μs) and a 6 MPa peak rarefactional pressure was used to induce ADV on endothelial cells in media of different viscosities. Carboxylmethyl cellulose was added to the cell media to increase the viscosity up to 300 cP to and aid in the reduction of stresses during bubble expansion. The likelihood of cell damage was decreased when compared to our control (~1 cP), but it was still present in some cases indicating that the mechanism of damage does not depend entirely on viscous stresses associated with bubble expansion. This work was supported by NIH Grant R01EB006476.

  16. Are endothelial cell bioeffects from acoustic droplet vaporization proximity dependent?

    Science.gov (United States)

    Seda, Robinson; Li, David; Fowlkes, J. Brian; Bull, Joseph

    2013-11-01

    Acoustic droplet vaporization (ADV) produces gas microbubbles that provide a means of selective occlusion in gas embolotherapy. Vaporization and subsequent occlusion occur inside blood vessels supplying the targeted tissue, such as tumors. Theoretical and computational studies showed that ADV within a vessel can impart high fluid mechanical stresses on the vessel wall. Previous in vitro studies have demonstrated that vaporization at an endothelial layer may affect cell attachment and viability. The current study is aimed at investigating the role of vaporization distance away from the endothelial layer. HUVECs were cultured in OptiCell™ chambers until reaching confluence. Dodecafluoropentane microdroplets were added, attaining a 10:1 droplet to cell ratio. A single ultrasound pulse (7.5 MHz) consisting of 16 cycles (~ 2 μs) and a 5 MPa peak rarefactional pressure was used to produce ADV while varying the vaporization distance from the endothelial layer (0 μm, 500 μm, 1000 μm). Results indicated that cell attachment and viability was significantly different if the distance was 0 μm (at the endothelial layer). Other distances were not significantly different from the control. ADV will significantly affect the endothelium if droplets are in direct contact with the cells. Droplet concentration and flow conditions inside blood vessels may play an important role. This work was supported by NIH grant R01EB006476.

  17. The Impact of Abstract versus Concrete Product Communications on Consumer Decision-making Processes

    NARCIS (Netherlands)

    M.N.G. van Ginkel-Bieshaar (Mirjam)

    2012-01-01

    textabstractWith the growth of online shopping, a new era of market communication is administered. Internet as a combined communication- and sales-channel has blurred the borders between persuasive communications to activate goals (i.e., abstract messages that are traditionally communicated via adve

  18. Detection diversity of multiantenna spectrum sensors

    NARCIS (Netherlands)

    Vazquez-Vilar, G.; Lopez-Valcarce, R.; Pandharipande, A.

    2011-01-01

    We investigate the performance of detectors with M antennas (co-located or distributed) under Rayleigh fading, in terms of detection diversity. Rather than the high-SNR concept of diversity order common in the communications literature, we adopt the notion recently advocated by Daher and Adve in the

  19. Analysis on Impacts and Co-Abatement Effects of Implementing the Low Carbon Cement Standard

    Directory of Open Access Journals (Sweden)

    Jun Pang

    2014-01-01

    Citation: Pang, J., Y.-C. Shi, X.-Z. Feng, et al., 2014: Analysis on impacts and co-abatement effects of implementing the low carbon cement standard.Adv. Clim. Change Res.,5(1, doi: 10.3724/SP.J.1248.2014.041.

  20. Measuring violations of General Relativity from single gravitational wave detection by non-spinning binary systems: higher-order asymptotic analysis

    CERN Document Server

    Tso, Rhondale

    2015-01-01

    A frequentist asymptotic expansion method for error estimation is employed for a network of gravitational wave detectors to assess the capability of gravitational wave observations, with Adv. LIGO and Adv. Virgo, to distinguish between the post-Einsteinian (ppE) description of coalescing binary systems and that of GR. When such errors are smaller than the parameter value, there is possibility to detect these violations from GR. A parameter space with inclusion of dominant dephasing ppE parameters is used for a study of first- and second-order (co)variance expansions, focusing on the inspiral stage of a nonspinning binary system of zero eccentricity detectible through Adv. LIGO and Adv. Virgo. Our procedure is more reliable than frequentist studies based only on Fisher information estimates and complements Bayesian studies. Second-order asymptotics indicate the possibility of constraining deviations from GR in low-SNR ($\\rho \\sim 15-17$) regimes. The errors on $\\beta$ also increase errors of other parameters s...