WorldWideScience

Sample records for adv funct mater

  1. Stabat Mater. Chant gregorien / Patric Wiklacz

    Index Scriptorium Estoniae

    Wiklacz, Patric

    1997-01-01

    Uuest heliplaadist "Stabat Mater. Chant gregorien. Palestrina: Stabat Mater a 8; Pärt: Stabat Mater; Browne: Stabat Mater dolorosa a 6. Fretwork (concort de violes)". Virgin Classics 545 272-2 (CD: 167F)

  2. Alternative Plasmonic Materials: Alternative Plasmonic Materials: Beyond Gold and Silver (Adv. Mater. 24/2013)

    DEFF Research Database (Denmark)

    Naik, Gururaj V.; Shalaev, Vladimir M.; Boltasseva, Alexandra

    2013-01-01

    Beyond Silver and Gold: Better material buildingblocks are essential in transforming the novel ideas of plasmonics and metamaterials into technologies of the future, as reviewed by Alexandra Boltasseva and co-workers on page 3264. Devices built from tailored materials offer improved performance...

  3. Light-Emitting Diodes: Phosphorescent Nanocluster Light-Emitting Diodes (Adv. Mater. 2/2016).

    Science.gov (United States)

    Kuttipillai, Padmanaban S; Zhao, Yimu; Traverse, Christopher J; Staples, Richard J; Levine, Benjamin G; Lunt, Richard R

    2016-01-13

    On page 320, R. R. Lunt and co-workers demonstrate electroluminescence from earth-abundant phosphorescent metal halide nanoclusters. These inorganic emitters, which exhibit rich photophysics combined with a high phosphorescence quantum yield, are employed in red and near-infrared light-emitting diodes, providing a new platform of phosphorescent emitters for low-cost and high-performance light-emission applications.

  4. Carbon Nanotubes: Printed Carbon Nanotube Electronics and Sensor Systems (Adv. Mater. 22/2016).

    Science.gov (United States)

    Chen, Kevin; Gao, Wei; Emaminejad, Sam; Kiriya, Daisuke; Ota, Hiroki; Nyein, Hnin Yin Yin; Takei, Kuniharu; Javey, Ali

    2016-06-01

    Printed electronics and sensors enable new applications ranging from low-cost disposable analytical devices to large-area sensor networks. Recent progress in printed carbon nanotube electronics in terms of materials, processing, devices, and applications is discussed on page 4397 by A. Javey and co-workers. The research challenges and opportunities regarding the processing and system-level integration are also discussed for enabling of practical applications.

  5. Nanoscale Electrodes: Nanoscale Electrodes for Flexible Electronics by Swelling Controlled Cracking (Adv. Mater. 30/2016).

    Science.gov (United States)

    Zhao, Qiang; Wang, Wenjun; Shao, Jinyou; Li, Xiangming; Tian, Hongmiao; Liu, Lu; Mei, Xuesong; Ding, Yucheng; Lu, Bingheng

    2016-08-01

    The fabrication of nanospaced electrodes on a flexible substrate is a great challenge. W. Wang, J. Shao, and co-workers propose a novel approach to fabricate nanogap electrodes for flexible electronics using a swelling-controlled cracking method, which is described on page 6337. This method has the advantages of high applicability, parallel manufacturing capacity, and compatibility with flexible substrates. It provides a new way to create high-performance flexible electronics in a cost-efficient fashion.

  6. From Virgil to Alma Mater

    Science.gov (United States)

    Spitz, Ellen Handler

    2007-01-01

    For a college to become an alma mater in the hearts of its students, it must show, true to the Latin meaning, the wisdom and comfort of a good foster mother. Since "alma mater" is Latin, and since the study of Latin has waned on all educational levels in both pious and secular milieus, the author wonders whether folks who use that term really know…

  7. Flexible Batteries: Hierarchical Assemblies of Carbon Nanotubes for Ultraflexible Li-Ion Batteries (Adv. Mater. 31/2016).

    Science.gov (United States)

    Ahmad, Shahab; Copic, Davor; George, Chandramohan; De Volder, Michael

    2016-08-01

    An advanced battery architecture composed of 3D carbon nanotube (CNT) current collectors is used to mitigate stresses in flexible batteries. On Page 6705, C. George, M. De Volder, and co-workers describe the fabrication process and characteristics of this new generation of ultraflexible batteries, which show high rate and cyclablility. These batteries may find applications in the powering of flexible displays and logics.

  8. Organosilica: Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic-Inorganic Hybridization into Frameworks (Adv. Mater. 17/2016).

    Science.gov (United States)

    Chen, Yu; Shi, Jianlin

    2016-05-01

    Organic-inorganic hybrid materials can combine the advantages of organic and inorganic materials, and overcome their drawbacks accordingly. On page 3235, Y. Chen and J. L. Shi review and discuss research progress on the design, synthesis, structure, and composition control of organic-inorganic hybrid mesoporous organosilica nanoparticles (MONs). Extensive applications of MONs in nanotechnology, mainly in nanomedicine, nanocatalysis and nanofabrication are discussed.

  9. Carbon Nanotubes: Ultrabreathable and Protective Membranes with Sub-5 nm Carbon Nanotube Pores (Adv. Mater. 28/2016).

    Science.gov (United States)

    Bui, Ngoc; Meshot, Eric R; Kim, Sangil; Peña, José; Gibson, Phillip W; Wu, Kuang Jen; Fornasiero, Francesco

    2016-07-01

    A flexible membrane with sub-5 nm single-walled carbon nanotube (SWNT) pores is developed by F. Fornasiero and co-workers, as described on page 5871, for application as a key component of protective, yet breathable fabrics. The SWNTs are shown to enable exceptionally fast transport of water vapor under a concentration driving force. Thus, membranes having SWNTs as moisture-conductive pores feature outstanding breathability and provide a high degree of protection from biological threats by size exclusion.

  10. Photonic Crystals: Two-Dimensional Programmable Manipulation of Magnetic Nanoparticles on-Chip (Adv. Mater. 15/2014)

    DEFF Research Database (Denmark)

    Sarella, Anandakumar; Torti, Andrea; Donolato, Marco

    2014-01-01

    P. Vavassori and co-workers demonstrate on page 2384 that field-controlled displacement of magnetic domain walls in ferromagnetic nano-ring structures allows for capture and 2-dimensional remote manipulation of fluidborne magnetic nanoparticles over a chip surface.......P. Vavassori and co-workers demonstrate on page 2384 that field-controlled displacement of magnetic domain walls in ferromagnetic nano-ring structures allows for capture and 2-dimensional remote manipulation of fluidborne magnetic nanoparticles over a chip surface....

  11. Self-Assembled Monolayers: Star-Shaped Crystallographic Cracking of Localized Nanoporous Defects (Adv. Mater. 33/2015).

    Science.gov (United States)

    Renner, Frank Uwe; Ankah, Genesis Ngwa; Bashir, Asif; Ma, Duancheng; Biedermann, P Ulrich; Shrestha, Buddha Ratna; Nellessen, Monika; Khorashadizadeh, Anahita; Losada-Pérez, Patricia; Duarte, Maria Jazmin; Raabe, Dierk; Valtiner, Markus

    2015-09-02

    On page 4877, F. U. Renner, A. Bashir, M. Valtiner, and co-workers describe a star-like dealloying corrosion morphology that appears during the localized attack of smooth well-prepared Cu-Au surfaces. The surfaces are initially protected by thiol or selenol inhibitior films. Localized dealloying of Cu-Au produces nanoporous gold under stress and crystallographic cracks - thereby opening a new approach combining surface science with nanoscale mechanical testing.

  12. 3D Printing: 3D Printing of Shape Memory Polymers for Flexible Electronic Devices (Adv. Mater. 22/2016).

    Science.gov (United States)

    Zarek, Matt; Layani, Michael; Cooperstein, Ido; Sachyani, Ela; Cohn, Daniel; Magdassi, Shlomo

    2016-06-01

    On page 4449, D. Cohn, S. Magdassi, and co-workers describe a general and facile method based on 3D printing of methacrylated macromonomers to fabricate shape-memory objects that can be used in flexible and responsive electrical circuits. Such responsive objects can be used in the fabrication of soft robotics, minimal invasive medical devices, sensors, and wearable electronics. The use of 3D printing overcomes the poor processing characteristics of thermosets and enables complex geometries that are not easily accessible by other techniques.

  13. FunctSNP: an R package to link SNPs to functional knowledge and dbAutoMaker: a suite of Perl scripts to build SNP databases

    Directory of Open Access Journals (Sweden)

    Watson-Haigh Nathan S

    2010-06-01

    Full Text Available Abstract Background Whole genome association studies using highly dense single nucleotide polymorphisms (SNPs are a set of methods to identify DNA markers associated with variation in a particular complex trait of interest. One of the main outcomes from these studies is a subset of statistically significant SNPs. Finding the potential biological functions of such SNPs can be an important step towards further use in human and agricultural populations (e.g., for identifying genes related to susceptibility to complex diseases or genes playing key roles in development or performance. The current challenge is that the information holding the clues to SNP functions is distributed across many different databases. Efficient bioinformatics tools are therefore needed to seamlessly integrate up-to-date functional information on SNPs. Many web services have arisen to meet the challenge but most work only within the framework of human medical research. Although we acknowledge the importance of human research, we identify there is a need for SNP annotation tools for other organisms. Description We introduce an R package called FunctSNP, which is the user interface to custom built species-specific databases. The local relational databases contain SNP data together with functional annotations extracted from online resources. FunctSNP provides a unified bioinformatics resource to link SNPs with functional knowledge (e.g., genes, pathways, ontologies. We also introduce dbAutoMaker, a suite of Perl scripts, which can be scheduled to run periodically to automatically create/update the customised SNP databases. We illustrate the use of FunctSNP with a livestock example, but the approach and software tools presented here can be applied also to human and other organisms. Conclusions Finding the potential functional significance of SNPs is important when further using the outcomes from whole genome association studies. FunctSNP is unique in that it is the only R

  14. Using Amphiphilic Nanostructures to Enable Long-Range Ensemble Coalescence and Surface Rejuvenation in Dropwise Condensation

    Science.gov (United States)

    2012-01-01

    authors declare no competing financial interest. Acknowledgment. AFOSR BIONIC Center (Award No. FA9550- 09-1-0162) provided financial support for this...Koratkar, N.; Yao, S.; Wang, Z. Nanograssed Micropyramidal Architectures for Contin- uous Dropwise Condensation. Adv. Funct. Mater. 2011, 21, 4617–4623. 18

  15. "Mater puerorum'. A medieval naming for an enigmatic children's disease.

    Science.gov (United States)

    Kottek, S S

    1981-09-01

    The pediatric clinical entity called "Mater Puerorum' appears first in the latin translation of Rhazes' "Practica Puerorum' and in his "Continens'. His descriptions of the disease could give some likeness either to a diagnosis of night terrors, or of hyperpyretic convulsions, or of a slight form of epilepsy. Mater Puerorum is afterwards described by most pediatric authors till the Renaissance period without much originality. Rhazes being one of their main sources anyway. Mater Puerorum has been considered by Still and Radbill as a synonym for hysterical fits in children. Going back to the Arabic original naming: Ummu's Sibyan, we venture another etymology based on Babylonian-Judeo-Arabic demonology. The "Mother of the Children' could be the female demon Karina--or Lilith--which is said to come to plague the children at night. The naming Mater Puerorum could thus be ascribed to a folklore origin, rather than to hysteria.

  16. From channel-forming ionic liquid crystals exhibiting humidity-induced phase transitions to nanostructured ion-conducting polymer membranes (adv. Mater. 26/2013).

    Science.gov (United States)

    Zhang, Heng; Li, Lei; Möller, Martin; Zhu, Xiaomin; Rueda, Jaime J Hernandez; Rosenthal, Martin; Ivanov, Dimitri A

    2013-07-12

    A novel wedge-shaped amphiphilic molecule bearing a sulfonate group at the tip displays humidity-induced phase transitions from a hexagonal columnar structure to a bicontinuous cubic phase. The mesophases can be frozen by photopolymerization of acrylic end-groups resulting in free-standing membranes with different topology of ionic nanochannels. The obtained membranes with a well-ordered ionic channel structure hold promise for applications in separation and catalysis.

  17. Microfluidics-Based Biosensors: A Microfluidic Paper-Based Origami Nanobiosensor for Label-Free, Ultrasensitive Immunoassays (Adv. Healthcare Mater. 11/2016).

    Science.gov (United States)

    Li, Xiao; Liu, Xinyu

    2016-06-01

    The first microfluidic paper-based origami nano-biosensor featuring zinc oxide nanowires and an electrochemical impedance spectroscopy biosensing mechanism, for label-free, ultrasensitive immunoassays is reported by X. Li and X. Liu on page 1326. The sensor consists of cellulose paper, a carbon ink electrode, and zinc oxide nanowires directly grown on the top. Possible parallelization of assays and high storage stability render the sensor promising for clinical diagnostics applications.

  18. Explosives: Metal-Organic Framework Templated Synthesis of Copper Azide as the Primary Explosive with Low Electrostatic Sensitivity and Excellent Initiation Ability (Adv. Mater. 28/2016).

    Science.gov (United States)

    Wang, Qianyou; Feng, Xiao; Wang, Shan; Song, Naimeng; Chen, Yifa; Tong, Wenchao; Han, Yuzhen; Yang, Li; Wang, Bo

    2016-07-01

    On page 5837, L. Yang, B. Wang, and co-workers describe a metal-organic framework (MOF) templating method to synthesize copper azide uniformly anchored in a 3D interconnected carbon matrix and evenly spaced by the electron-conductive joints. This strategy sheds light on the preparation of powerful yet safe primary explosives and fulfills the need for controllable explosive systems.

  19. Field-Effect Transistors: Ultrathin MXene-Micropattern-Based Field-Effect Transistor for Probing Neural Activity (Adv. Mater. 17/2016).

    Science.gov (United States)

    Xu, Bingzhe; Zhu, Minshen; Zhang, Wencong; Zhen, Xu; Pei, Zengxia; Xue, Qi; Zhi, Chunyi; Shi, Peng

    2016-05-01

    A field-effect transistor (FET) based on ultrathin Ti3 C2 -MXene micropatterns is developed by C. Zhi, P. Shi, and co-workers, as described on page 3333. The FET can be utilized for label-free probing of small molecules in typical biological environments, e.g., for fast detection of action potentials in primary neurons. This device is produced with a microcontact printing technique, harnessing the unique advantages for easy fabrication.

  20. Cellular Microcultures: Programming Mechanical and Physicochemical Properties of 3D Hydrogel Cellular Microcultures via Direct Ink Writing (Adv. Healthcare Mater. 9/2016).

    Science.gov (United States)

    McCracken, Joselle M; Badea, Adina; Kandel, Mikhail E; Gladman, A Sydney; Wetzel, David J; Popescu, Gabriel; Lewis, Jennifer A; Nuzzo, Ralph G

    2016-05-01

    R. Nuzzo and co-workers show on page 1025 how compositional differences in hydrogels are used to tune their cellular compliance by controlling their polymer mesh properties and subsequent uptake of the protein poly-l-lysine (green spheres in circled inset). The cover image shows pyramid micro-scaffolds prepared using direct ink writing (DIW) that differentially direct fibroblast and preosteoblast growth in 3D, depending on cell motility and surface treatment.

  1. Photoacoustic Imaging: Semiconducting Oligomer Nanoparticles as an Activatable Photoacoustic Probe with Amplified Brightness for In Vivo Imaging of pH (Adv. Mater. 19/2016).

    Science.gov (United States)

    Miao, Qingqing; Lyu, Yan; Ding, Dan; Pu, Kanyi

    2016-05-01

    Despite the great potential of photoacoustic imaging in the life sciences, the development of smart activatable photoacoustic probes remains elusive. On page 3662, K. Pu and co-workers report a facile nanoengineering approach based on semiconducting oligomer nano-particles to develop ratiometric photoacoustic probes with amplified brightness and enhanced sensing capability for accurate photoacoustic mapping of pH in the tumors of living mice.

  2. 3D Printing: 3D Printing of Conductive Complex Structures with In Situ Generation of Silver Nanoparticles (Adv. Mater. 19/2016).

    Science.gov (United States)

    Fantino, Erika; Chiappone, Annalisa; Roppolo, Ignazio; Manfredi, Diego; Bongiovanni, Roberta; Pirri, Candido Fabrizio; Calignano, Flaviana

    2016-05-01

    On page 3712, E. Fantino, A. Chiappone, and co-workers fabricate conductive 3D hybrid structures by coupling the photo-reduction of metal precursors with 3D printing technology. The generated structures consist of metal nanoparticles embedded in a polymer matrix shaped into complex multilayered architectures. 3D conductive structures are fabricated with a digital light-processing printer incorporating silver salt into photocurable formulations.

  3. Photovoltaics: Highly Efficient Hybrid Photovoltaics Based on Hyperbranched Three-Dimensional TiO 2 Electron Transporting Materials (Adv. Mater. 18/2015)

    KAUST Repository

    Mahmood, Khalid

    2015-05-01

    Solution-processed hybrid photovoltaics are a potentially disruptive third-generation solar cell technology. On page 2859, A. Amassian and co-workers demonstrate that an electrospun hyperbranched electron-transporting material is capable of achieving highly efficient hybrid solar cells across different platforms, including lead-halide perovskites (15.5%) and dye-sensitized solar cells (11.2%).

  4. Photodetectors: Broad Detection Range Rhenium Diselenide Photodetector Enhanced by (3-Aminopropyl)Triethoxysilane and Triphenylphosphine Treatment (Adv. Mater. 31/2016).

    Science.gov (United States)

    Jo, Seo-Hyeon; Park, Hyung-Youl; Kang, Dong-Ho; Shim, Jaewoo; Jeon, Jaeho; Choi, Seunghyuk; Kim, Minwoo; Park, Yongkook; Lee, Jaehyeong; Song, Young Jae; Lee, Sungjoo; Park, Jin-Hong

    2016-08-01

    The effects of triphenylphosphine (PPh3 ) and (3-amino-propyl)triethoxysilane (APTES) on a rhenium diselenide (ReSe2 ) photodetector are systematically studied by J.-H. Park and co-workers on page 6711 in comparison with a conventional MoS2 device. A very high performance ReSe2 photodetector is demonstrated, which has a broad photodetection range, high photoresponsivity (1.18 × 10(6) A W(-1) ), and fast photoswitching speed (rising/decaying time: 58/263 ms).

  5. 76 FR 255 - Amendments To Form ADV; Extension of Compliance Date

    Science.gov (United States)

    2011-01-04

    ... COMMISSION 17 CFR Parts 275 and 279 RIN 3235-AI17 Amendments To Form ADV; Extension of Compliance Date AGENCY: Securities and Exchange Commission. ACTION: Final rule; extension of compliance date. SUMMARY: The Securities and Exchange Commission is extending the compliance date for Part 2B of Form ADV, the...

  6. Advérbios modalizadores discursivos, advérbios de comentário avaliativos ou palavras modais?: um estudo comparativo das descrições gramaticais do item lexical advérbio em português e alemão

    OpenAIRE

    Salgado, Janaina Lopes

    2012-01-01

    Este artigo apresenta contrastivamente os diferentes tipos de categorização gramatical do item lexical advérbio em uma gramática brasileira e em duas alemãs. O objetivo é apontar a complexidade de descrição do advérbio em uma classe única. A característica heterogeneidade do advérbio é exemplificada por três tipos de advérbio: advérbios modalizadores discursivos (CASTILHO 2010), advérbios de comentário (DUDEN 2006) e palavras modais (HELBIG & BUSCHA 2001).

  7. 域名系统运行机制与对ADV-DNS的扩展%DNS MECHANISM AND EXTENDING OF ADV-DNS

    Institute of Scientific and Technical Information of China (English)

    袁兆山; 宋宇; 袁曙

    2001-01-01

    本文分析了目前DNS的解析过程,并基于ADV-DNS,提出一种扩展的ADV-DNS设计模型 .它采用单向解析查询请求,进一步减少了查询的响应延迟,减少了对信道的占用,从而大大的减轻了国际和国内信道的负载.

  8. Complete Genome Sequence of Bacillus megaterium Myophage Mater

    OpenAIRE

    Lancaster, Jacob C.; Hodde, Mary K.; Hernandez, Adriana C.; Kuty Everett, Gabriel F.

    2015-01-01

    Bacillus megaterium is a ubiquitous, soil inhabiting Gram-positive bacterium that is a common model organism and is used in industrial applications for protein production. The following reports the complete sequencing and annotation of the genome of B. megaterium myophage Mater and describes the major features identified.

  9. The Labour Market Effects of "Alma Mater": Evidence from Italy

    Science.gov (United States)

    Brunello, Giorgio; Cappellari, Lorenzo

    2008-01-01

    We use data from a nationally representative survey of Italian graduates to study whether "Alma Mater" matters for employment and earnings 3 years after graduation. We find that the attended college matters, and that there are important college-related differences, both among and within regions of the country. These differences, however,…

  10. Research on ADV-Hop localization algorithm in wireless sensor networks

    Science.gov (United States)

    Zhao, Shijun; Xu, Xiulan; Zhang, Zhaohui; Sun, Meiling

    2008-10-01

    Wireless sensor networks (WSN) have wide applicability to many important applications including environmental monitoring, military applications and disaster management, etc. In many applications, sensors are assumed to know their absolute locations. Some localization methods of WSN have been proposed. In these methods, nodes equipped with GPS to get precise location information, namely the anchor nodes, are employed to derive the locations of other nodes. Most of the recent work focuses on increasing the accuracy in position estimation. In this paper, aiming at the high communication cost and average positioning error of DV-hop algorithm, an advanced algorithm which is called ADV-hop algorithm is proposed. Simulations are made by the network simulator NS2. The simulation results show that ADV-hop algorithm has lower communication cost and smaller average positioning error than DV-hop algorithm, which makes ADV-hop algorithm more suitable for the node location of WSN.

  11. Local-Level Prognostics Health Management Systems Framework for Passive AdvSMR Components. Interim Report

    Energy Technology Data Exchange (ETDEWEB)

    Ramuhalli, Pradeep [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Roy, Surajit [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hirt, Evelyn H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Pardini, Allan F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Jones, Anthony M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Deibler, John E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States; Pitman, Stan G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States; Tucker, Joseph C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States; Prowant, Matthew S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States; Suter, Jonathan D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States

    2014-09-12

    This report describes research results to date in support of the integration and demonstration of diagnostics technologies for prototypical AdvSMR passive components (to establish condition indices for monitoring) with model-based prognostics methods. The focus of the PHM methodology and algorithm development in this study is at the localized scale. Multiple localized measurements of material condition (using advanced nondestructive measurement methods), along with available measurements of the stressor environment, enhance the performance of localized diagnostics and prognostics of passive AdvSMR components and systems.

  12. Cavernous hemangioma of the dura mater mimicking meningioma

    Science.gov (United States)

    Di Vitantonio, Hambra; De Paulis, Danilo; Ricci, Alessandro; Marzi, Sara; Dehcordi, Soheila Raysi; Galzio, Renato Juan

    2015-01-01

    Background: Cavernomas are benign lesions that most commonly occur intra-parenchymally, but occasionally they have been described as arising from the dura mater. Extra-axial cavernous angiomas (or hemangiomas) account for 0.4–2% of all intracranial vascular malformations, and they usually occur in the middle cranial fossa, associated with the cavernous sinus. Other possible localizations (e.g. tentorium, convexity, anterior cranial fossa, cerebellopontine angle, Meckel's cave, sella turcica and internal auditory meatus) are rare, and they account only for 0.2–0.5%. Case Description: We report a case of a 30-year-old female presenting with a 2 years history of headache unresponsive to drug therapy. The magnetic resonance imaging showed a dural-based lesion in the left frontal region; the lesion size was: 1.5 cm × 3.5 cm. The appearance suggested a convexity meningioma. A left frontal craniotomy was performed, and the histopathological diagnosis deposed for a cavernous hemangioma of the dura mater. The follow-up at 1-year was good without any neurologic deficit. Conclusions: Dural-based cavernous hemangiomas of the convexity are uncommon lesions. Up to now, only 13 cases have been described in the literature. The authors have discussed clinical aspects, radiological features, surgical treatment, and operative findings. PMID:26421218

  13. In situ estimation of erosion and deposition thresholds by Acoustic Doppler Velocimeter (ADV)

    DEFF Research Database (Denmark)

    Andersen, T.J.; Fredsøe, Jørgen; Pejrup, M.

    2007-01-01

    Field-based estimations of bed shear stress have been made using SonTek/YSI 10 MHz ADVs (Acoustic Doppler Velocimeter) at the Kongsmark mudflat, Danish Wadden Sea, in order to test if it was possible to estimate erosion and deposition thresholds in situ by use of unidirectional tidal and orbital...... (wave) currents. The results were promising and erosion thresholds were in the same range as those observed in EROMES erosion experiments carried out at the same site. Similarly, the short-term erosion rates which could be calculated matched closely those obtained with EROMES, and were in the same range...... as those published for a large annular flume (Sea Carousel) from another fine-grained site. This indicates that the erosion rates obtained with those two erosion-instruments are reasonable estimates of the actual erosion taking place under natural tidal current and waves. One advantage of the use of ADVs...

  14. Treatment for infection of artificial dura mater using free fascia lata.

    Science.gov (United States)

    Nakano, Takashi; Yoshikawa, Katsuhiro; Kunieda, Takeharu; Arakawa, Yoshiki; Kikuchi, Takayuki; Yamawaki, Satoko; Naitoh, Motoko; Kawai, Katsuya; Suzuki, Shigehiko

    2014-07-01

    Synthetic artificial dura mater materials, such as expanded polytetrafluoroethylene sheets, are widely used in dura mater reconstruction in cases involving brain tumors or trauma surgery. In patients with postoperative infection related to the use of artificial dura mater, surgical debridement of the infected wound and removal of the artificial dura mater materials are necessary to control infection. In cases involving cerebrospinal fluid leakage, dura mater reconstruction must be performed immediately. Many useful techniques for performing dura mater reconstruction to treat postoperative infection have been reported; however, some have drawbacks with respect to the need for microvascular anastomosis or difficulties in obtaining watertight closure. We successfully treated 6 patients with postoperative artificial dura mater infection using free thigh fascia lata. Some surgeons believe that the use of free fascia in infected wounds is dangerous because free fascia is a non-vascularized tissue. However, performing complete debridement and covering such free fascia with well-vascularized tissue allow the fascia to become vascularized and tolerant of infection. Therefore, if the blood flow in the scalp is acceptable after a sufficient debridement, free fascia lata can be used for reconstruction in patients with postoperative infection of artificial dura mater. Furthermore, skull reconstruction can be performed safely and easily with solid-type artificial bone, sometimes combined with tissue expansion, thus resulting in good aesthetic outcomes.

  15. Performance of Implementation IBR-DTN and Batman-Adv Routing Protocol in Wireless Mesh Networks

    Directory of Open Access Journals (Sweden)

    Herman Yuliandoko

    2016-03-01

    Full Text Available Wireless mesh networks is a network which has high mobility and flexibility network. In Wireless mesh networks nodes are free to move and able to automatically build a network connection with other nodes. High mobility, heterogeneous condition and intermittent network connectivity cause data packets drop during wireless communication and it becomes a problem in the wireless mesh networks. This condition can happen because wireless mesh networks use connectionless networking type such as IP protocol which it is not tolerant to delay. To solve this condition it is needed a technology to keep data packets when the network is disconnect. Delay tolerant technology is a technology that provides store and forward mechanism and it can prevent packet data dropping during communication. In our research, we proposed a test bed wireless mesh networks implementation by using proactive routing protocol and combining with delay tolerant technology. We used Batman-adv routing protocol and IBR-DTN on our research. We measured some particular performance aspect of networking such as packet loss, delay, and throughput of the network. We identified that delay tolerant could keep packet data from dropping better than current wireless mesh networks in the intermittent network condition. We also proved that IBR-DTN and Batman-adv could run together on the wireless mesh networks. In The experiment throughput test result of IBR-DTN was higher than Current TCP on the LoS (Line of Side and on environment with obstacle. Keywords: Delay Tolerant, IBR-DTN, Wireless Mesh, Batman-adv, Performance

  16. Cranial Reconstruction following the Removal of an Infected Synthetic Dura Mater Substitute

    Directory of Open Access Journals (Sweden)

    Nobutaka Yoshioka, MD

    2014-04-01

    Conclusions: Staged cranial reconstruction after the removal of an infected synthetic dura mater substitute using an algorithmic approach is feasible and safe, produces satisfactory cosmetic results, and is not associated with any complications.

  17. Tumor-targeted gene therapy using Adv-AFP-HRPC/IAA prodrug system suppresses growth of hepatoma xenografted in mice.

    Science.gov (United States)

    Dai, M; Liu, J; Chen, D-E; Rao, Y; Tang, Z-J; Ho, W-Z; Dong, C-Y

    2012-02-01

    Clinical efficacy of current therapies for hepatocellular carcinoma (HCC) treatment is limited. Indole-3-acetic acid (IAA) is non-toxic for mammalian cells. Oxidative decarboxylation of IAA by horseradish peroxidase (HRP) leads to toxic effects of IAA. The purpose of this study was to investigate the effects of a novel gene-targeted enzyme prodrug therapy with IAA on hepatoma growth in vitro and in vivo mouse hepatoma models. We generated a plasmid using adenovirus to express HRP isoenzyme C (HRPC) with the HCC marker, alpha-fetoprotein (AFP), as the promoter (pAdv-AFP-HRPC). Hepatocellular cells were infected with pAdv-AFP-HRPC and treated with IAA. Cell death was detected using MTT assay. Hepatoma xenografts were developed in mice by injection of mouse hepatoma cells. The size and weight of tumors and organs were evaluated. Cell death in tumors was assessed using hematoxylin and eosin-stained tissue sections. HRPC expression in tissues was detected using Reverse Transcriptase-Polymerase Chain Reaction. IAA stimulated death of hepatocellular cells infected with pAdv-AFP-HRPC, in a dose- and time-dependent manner, but not in control cells. Growth of hepatoma xenografts, including the size and weight, was inhibited in mice treated with pAdv-AFP-HRPC and IAA, compared with that in control group. pAdv-AFP-HRPC/IAA treatment induced cell death in hepatoma xenografts in mice. HRPC gene expressed only in hepatoma, but not in other normal organs of mice. pAdv-AFP-HRPC/IAA treatment did not cause any side effects on normal organs. These findings suggest that pAdv-AFP-HRPC/IAA enzyme/prodrug system may serve as a strategy for HCC therapy.

  18. Real-time video compression system design and hardware implementation based on multiple ADV212

    Institute of Scientific and Technical Information of China (English)

    徐冬冬

    2016-01-01

    In order to improve the transmission rate of the compression system , a real-time video lossy compression system based on multiple ADV 212 is proposed and achieved .Considering the CMOS video format and the working principle of ADV 212 , a Custom-specific mode is used for various video formats firstly .The data can be cached through the FPGA internal RAM and SDRAM Ping-Pong op-eration.And the working efficiency is greatly promoted .Secondly, this method can realize direct code stream transmission or do it after storage .Through the error correcting coding , the correction ability of the flash memory is highly improved .Lastly, the compression and de-compression circuit boards are involved to specify the performance of the method .The results show that the compression system has a real-time and stable performance .And the compression ratio can be changed arbitrarily by configuring the program .The compression system can be realized and the real-time performance is good with large amount of data .

  19. Mechanical and thermal properties of bacterial-cellulose-fibre-reinforced Mater-Bi® bionanocomposite

    Directory of Open Access Journals (Sweden)

    Hamonangan Nainggolan

    2013-05-01

    Full Text Available The effects of the addition of fibres of bacterial cellulose (FBC to commercial starch of Mater-Bi® have been investigated. FBC produced by cultivating Acetobacter xylinum for 21 days in glucose-based medium were purified by sodium hydroxide 2.5 wt % and sodium hypochlorite 2.5 wt % overnight, consecutively. To obtain water-free BC nanofibres, the pellicles were freeze dried at a pressure of 130 mbar at a cooling rate of 10 °C min−1. Both Mater-Bi and FBC were blended by using a mini twin-screw extruder at 160 °C for 10 min at a rotor speed of 50 rpm. Tensile tests were performed according to ASTM D638 to measure the Young’s modulus, tensile strength and elongation at break. A field emission scanning electron microscope was used to observe the morphology at an accelerating voltage of 10 kV. The crystallinity (Tc and melting temperature (Tm were measured by DSC. Results showed a significant improvement in mechanical and thermal properties in accordance with the addition of FBC into Mater-Bi. FBC is easily incorporated in Mater-Bi matrix and produces homogeneous Mater-Bi/FBC composite. The crystallinity of the Mater-Bi/FBC composites decrease in relation to the increase in the volume fraction of FBC.

  20. Photothermal Therapy: Cancer Cell Internalization of Gold Nanostars Impacts Their Photothermal Efficiency In Vitro and In Vivo: Toward a Plasmonic Thermal Fingerprint in Tumoral Environment (Adv. Healthcare Mater. 9/2016).

    Science.gov (United States)

    Espinosa, Ana; Silva, Amanda K A; Sánchez-Iglesias, Ana; Grzelczak, Marek; Péchoux, Christine; Desboeufs, Karine; Liz-Marzán, Luis M; Wilhelm, Claire

    2016-05-01

    Because the ultimate target for photothermal therapy is the cancer cell, heating performances must be evaluated intracellularly. On page 1040 C. Wilhelm and team provide the first in vitro and in vivo photothermal measurements in cancer cells with gold nanostars. They demonstrate that once nanostars are internalized within endosomes, heat generation can change significantly.

  1. Human Neuron Cultures: Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks (Adv. Healthcare Mater. 15/2016).

    Science.gov (United States)

    Burbulla, Lena F; Beaumont, Kristin G; Mrksich, Milan; Krainc, Dimitri

    2016-08-01

    Dimitri Krainc, Milan Mrksich, and co-workers demonstrate the utility of microcontact printing technology for culturing of human neurons in defined patterns over extended periods of time on page 1894. This approach facilitates studies of neuronal development, cellular trafficking, and related mechanisms that require assessment of individual neurons and neuronal networks.

  2. Evaluation of Acoustic Doppler Velocimeters (ADVs) and Pulse Coherent Acoustic Doppler Profiler (PCADP) in Estimating Suspended Sediment Concentration

    Science.gov (United States)

    Ha, H.; Maa, J.

    2008-12-01

    Laboratory experiments were conducted to estimate the suspended sediment concentration (SSC) or its profile using acoustic backscatter strengths. Three acoustic Doppler velocimeters (ADVs) with different frequencies (5, 10 and 16 MHz) and a pulse coherent acoustic Doppler profiler (PCADP) with 1.5 MHz were used with selected sediments: two different commercial clays and Clay Bank sediment in the York River. Each ADV showed different backscatter responses depending on the sediment type and SSC. Not all devices had a good linear relationship between backscatter strength and SSC. Within a limited range of SSC, however, the backscatter strength can be well correlated with the SSC. Compared with optical backscatter sensor (OBS), ADV's backscatter signals were too noisy to be directly converted to the fluctuation of SSC, due to high amplification ratio and small sampling volume. There is another unexpected response for the backscatter strength: high signals from small particles but low signals from large particles. This might be caused by the internal gain setting built in ADVs, which should be further clarified. For profiling the SSC, a PCADP was tested in a controlled water tank. The sound attenuation by sediments was included in the signal inversion algorithm since most target regions measured by PCADP are located at near-bed high concentration layer. Clay Bank sediment showed a higher correlation coefficient (r2=0.92) between range- corrected volume scattering and PCADP signal when SSCcontrolled by the particle size in suspension at a given frequency. The profiling test for Clay Bank sediments showed that the PCADP-derived SSC profile has a good agreement with sample- and OBS-derived outcomes. This study suggests that both ADV and PCADP are useful instruments to estimate the SSC if the aforementioned questions are clarified and the particle (floc) size is sufficiently large enough to be sensed.

  3. Interaction of ionizing radiation with mater; Oddzialywanie promieniowania jonizujacego z materia

    Energy Technology Data Exchange (ETDEWEB)

    Pogocki, D. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland)

    1997-10-01

    The early radiation effects (e.g. excitation, ionization) have been described and compared for different kind of radiation interacting with mater. The mechanism of energy deposition in connection with radiation dose and their spatial distribution has been shown.The commonly used definitions and units in radiation dosimetry have been also reviewed. 4 refs, 4 figs.

  4. To the Editor: comment on Eremets and Troyan, Nature Mater. 10, 927-931 (2011)

    OpenAIRE

    Goncharov, Alexander F.; Struzhkin, Viktor V.

    2012-01-01

    Eremets and Troyan (Nature Mater. 10, 927-931 (2011)) claim that they produced the conducting liquid hydrogen state at 270 GPa and 295 K. Their evidence consists of disappearance of Raman signals, visual observations, and measurements of electrical conductivity in diamond anvil cells (DAC). However, there is no proof that the reported observations are due to transformations in hydrogen.

  5. Evidence for CGRP re-uptake in rat dura mater encephali

    DEFF Research Database (Denmark)

    Gupta, Saurabh; Amrutkar, Dipak Vasantrao; Mataji, Aydin;

    2010-01-01

    Calcitonin gene-related peptide (CGRP) is widely distributed in the trigeminovascular system and released from sensory fibres of the cranial dura mater upon noxious stimulation. Such release may be a mechanism underlying migraine headache. Based on data from guinea pig basilar artery preparations...

  6. 基于多片ADV212芯片的图像压缩系统设计%Design of Image Compression System Based on Multiple ADV212 Chip

    Institute of Scientific and Technical Information of China (English)

    于巍巍; 马晓东; 孙娟; 郝修强

    2014-01-01

    At present,the technology of static image compression coder based on JPEG2000 standard is the occupied technology in satellite communications. The ADV212 chip is a special ASIC which can realize integrally JPEG2000 image compression. To reasonably schedule multiple ADV212 chips to realize jointly teamwork,a new image compression system is proposed and implemented in this paper. For large-scale image in high speed,this system can implement the lossy compres-sion or the lossless compression in real-time. Thus a coding method of high-speed large-capacity satellite image compression is established.%基于JPEG2000标准的静态图像压缩编码器技术是当前应用于卫星通信中的热点技术。 ADV212芯片是一款可以完整实现JPEG2000图像压缩的专用ASIC。文章介绍了一种通过合理调度多片ADV212芯片来实现联合工作的图像压缩系统的设计方法和实现过程,使得系统对高输入数据率的宽幅图像可以进行实时无损或者有损压缩,从而提供了一种高速率大容量卫星图像压缩编码方法。

  7. Claudia Quinta (Pro Caelio 34 and an altar to Magna Mater

    Directory of Open Access Journals (Sweden)

    Eleanor Winsor Leach

    2010-11-01

    Full Text Available Among the items of sculpture from the Capitoline collection now housed in the Museum of the Power Station Montemartini is a marble relief altar of the Claudian Period (E. Simon's dating dedicated to the mater deorum and the navis salvia and depicting the arrival of the goddess Cybele at Rome by ship. The dedicator is one Claudia Syntyche and the sculpture alludes to the legends attached to a much honored woman of the Claudian family whom Cicero, in his oration pro Caelio brought on stage in a cameo appearance to bolster his case against the controversial contemporary woman Clodia Metelli as one of the accusers of his client M. Caelius Rufus. This paper will consider questions raised by the iconography of the altar with reference to the development of Claudia's legend in Roman mythology and subsequently ask who was this Claudia the dedicator and why did she choose Magna Mater for her vow?

  8. The Neurospora Transcription Factor ADV-1 Transduces Light Signals and Temporal Information to Control Rhythmic Expression of Genes Involved in Cell Fusion

    Directory of Open Access Journals (Sweden)

    Rigzin Dekhang

    2017-01-01

    Full Text Available Light and the circadian clock have a profound effect on the biology of organisms through the regulation of large sets of genes. Toward understanding how light and the circadian clock regulate gene expression, we used genome-wide approaches to identify the direct and indirect targets of the light-responsive and clock-controlled transcription factor ADV-1 in Neurospora crassa. A large proportion of ADV-1 targets were found to be light- and/or clock-controlled, and enriched for genes involved in development, metabolism, cell growth, and cell fusion. We show that ADV-1 is necessary for transducing light and/or temporal information to its immediate downstream targets, including controlling rhythms in genes critical to somatic cell fusion. However, while ADV-1 targets are altered in predictable ways in Δadv-1 cells in response to light, this is not always the case for rhythmic target gene expression. These data suggest that a complex regulatory network downstream of ADV-1 functions to generate distinct temporal dynamics of target gene expression relative to the central clock mechanism.

  9. Tumefactive immunoglobulin G4-related disease involving the dura mater: A case report and literature review

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Hoon; Lee, Ji Hoon; Ko, Yong; Paik, Seoung Sam; Lee, Young Jun [Dept. of Radiology, Hanyang University Hospital, Seoul (Korea, Republic of); Park, Dong Woo [Dept. of Radiology, Hanyang University Hospital, Seoul (Korea, Republic of)

    2015-08-15

    Immunoglobulin G4 (IgG4)-related disease is a well-known disorder characterized by an inflammatory reaction with an increase in the number of IgG4-positive plasma cells associated with sclerosis. IgG4-related disease often affects the dura mater with a pattern of diffuse thickening when the central nervous system is involved. However, some nodular dural thickening requires discrimination from tumors because of obviously different treatment options. We report of a case of IgG4-related disease with tumefactive dural involvement.

  10. VARSTVO DELAVK MATER V LUČI NOVEJŠE SODNE PRAKSE EU

    OpenAIRE

    2011-01-01

    Uskladiti poklicno in družinsko življenje je velik izziv za delavke matere, sploh v današnjem času, ko sta v večini primerov zaposlena tako oče kot mati. Cilj na področju delovnega prava je zato zagotavljati delavkam materam posebno varstvo. S tem je mišljeno predvsem varstvo pred prekinitvijo poklicne poti zaradi materinstva. Veliko žensk se zanj namreč ne odloča ravno z razlogom bojazni pred odpovedjo pogodbe o zaposlitvi s strani delodajalca ter kolebanjem med materinstvom in kariero. Dipl...

  11. Antecedents to and outcomes of Rh(D) isoimmunization: Mater Mothers Hospital, Brisbane, 1988-1995.

    Science.gov (United States)

    Portmann, C; Ludlow, J; Joyce, A; Chan, F Y

    1997-02-01

    We analyzed the antecedents and outcomes of Rh(D) isoimmunization in a local population. Forty-two Rh(D) isoimmunized women attending Mater Mothers Hospital for antenatal care were identified through the Mater Hospital Blood Bank database; their records were reviewed for variables including sensitizing events, obstetric interventions and pregnancy outcomes. In this group, 74% of women became sensitized despite receiving anti-D immune globulin, 17% did not receive anti-D appropriately and the other failed to attend for treatment of bleeding in pregnancy. Antenatal sensitization was implicated in 6 women (14%) and potentially responsible for isoimmunization in another 18. Over half of the 80 viable pregnancies in this study group required some form of obstetric intervention. Thirty pregnancies required amniocentesis and 1 in 3 babies underwent either intrauterine or exchange transfusion. Three fetal deaths occurred as a result of severe disease. This study offers information highlighting circumstances in which immunoprophylaxis guidelines have failed to impart protection against Rh(D) sensitization and the consequences of such failures.

  12. Use of equine pericardium sheet (LYOMESH®) as dura mater substitute in endoscopic endonasal transsphenoidal surgery

    Science.gov (United States)

    Cavallo, Luigi M.; Solari, Domenico; Somma, Teresa; Di Somma, Alberto; Chiaramonte, Carmela; Cappabianca, Paolo

    Objective The aim of this study was to describe the use of equine pericardium sheet (Lyomesh ® ) as dural substitute for sellar reconstruction after endoscopic endonasal transsphenoidal surgery for the removal of pituitary adenomas. Methods We reviewed data of patients that underwent surgery by means of an endoscopic endonasal transsphenoidal approach for the removal of pituitary adenomas over a 12-months period, starting in May 2012, i.e. when we adopted Lyomesh ® (Audio Technologies, Piacenza, Italy) an equine pericardium sheet, as dura mater substitute. Results: During the 12-months period evaluated, we performed an endoscopic endonasal transsphenoidal operation for a variety of pituitary lesions on 102 consecutive patients. Among these, in 12 patients (9.4%) harboring a pituitary adenoma, the implant of the pericardium sheet was used. Four patients (33.3%) presented a small intraoperative cerebrospinal fluid (CSF) leak; in these cases the Lyomesh ® was placed intradurally with fibrin glue and, thereafter, several layers were positioned in extradural space. In 8 other subjects without any evidence of CSF leak, the dural substitute was placed intradurally and fibrin glue was injected intradurally to hold the material in place. Conclusions: Even if based on a relatively small patient series, our experience demonstrated that the use of equine pericardium sheet (Lyomesh ® ) as dura mater substitute in transsphenoidal surgery is safe and biocompatible, as compared with other dural substitutes. PMID:24251248

  13. MATER - Pianeta Terra-Mare: an interactive and multidisciplinary approach to Geosphere sciences

    Science.gov (United States)

    Piangiamore, Giovanna Lucia; Fanelli, Emanuela; Furia, Stefania; Garau, Daniela; Merlino, Silvia; Musacchio, Gemma; Carla Centineo, Maria

    2016-04-01

    Recent studies demonstrate that Earth and Marine Sciences are not properly treated in scholastic programs and in textbooks are included in a superficial way. These topics are interdisciplinary and experimental (biology, ecology, oceanography and geology) and the recent advance in these fields is strictly linked to technologic improvement. School cannot keep up with the huge advances of knowledge experimented in the last 20 years, also for the lack of didactic laboratories sufficiently updated to support experimental activities. In this context, in 2014-15 three Italian Research Institutes (INGV, ISMAR-CNR and ENEA-CRAM) have decided to support the Unified School District "ISA 10"of Lerici (Liguria, Italy) - comprehensive of kindergartner, primary and middle schools - to develop the project MATER - Pianeta Terra-Mare (Planet Earth and Sea). The acronym MATER (MARe and TERra) has also a gender value, as people involved in the projects were women, mostly researchers and teachers, which have worked side by side with other women belonging to environmental and cultural associations of the territory. This heterogeneous group has a common objective: to promote the diffusion of a scientific culture and to sensitize students from 3 to 14 years towards problems occurring in marine and terrestrial environments, fostering the settlement of a sustainable attitude to the exploitation of natural resources and consciousness to natural hazards, such as earthquakes and floods, quite common in the Ligurian region. MATER has been considered as one of the best projects funded by MIUR (Italian Ministry of Education, University and Research) inside the Dissemination of Scientific and Technological Culture call for the year 2014. Natural hazards (Planet Earth) and the chemical-physical aspects and resources of the marine environment (Planet Sea) were the two modules of the project. Planet Earth developed through Piovono Idee! (Cloudy with a chance of Ideas!), an interactive exhibition on

  14. Mater Nostra: The Anti-blasphemy Message of the Feminist Punk-Prayer

    Directory of Open Access Journals (Sweden)

    Elena Ivanovna Volkova

    2014-12-01

    Full Text Available In this essay I develop a blasphemy counter-discourse arguing that it was ecclesial and state authorities who committed blasphemies, which were condemned by Pussy Riot’s punk-prayer. Thus, the performance in this respect may be interpreted as an anti-blasphemy protest. The blasphemy list includes the collaboration of the church with the authoritarian state, known as heresy of Sergianism; Caesar and Temple idolatry, blasphemy against the Holy Spirit, Virgin Mary and Folly for Christ’s sake. The punk-prayer may be interpreted as a feminine version of the Lord’s Prayer – Mater Nostra. Several corporeal narratives in the background – women’s dress code and rape debates, Virgin Mary’s belt, and its alleged miraculous ability to help women to deliver a baby – may be seen as allegories of feminist vs. patriarchal opposition in Russian religious and political culture.

  15. Muusikapassioon mõttepeeglis. Täna kõlab "Stabat Mater" / Anne Peäske

    Index Scriptorium Estoniae

    Peäske, Anne, 1946-

    2005-01-01

    Arvo Pärdi "Passio" ettekandest 11.sept. Rakvere Kolmainu kirikus. Elmo Lööve, Raivo Palmaru, Jaan Rääts, Toivo Tulev, Aarne Talvik, Ingmar Kurg, Olev Oja ja Eleonora Pärt Arvo Pärdi muusikast. A. Pärdi "Stabat Mater" ansambli Theatre of Voices esituses 14. sept. Rakvere Kolmainu kirikus

  16. The Mater-Bi® biodegradable film for strawberry (Fragaria x ananassa Duch. mulching: effects on fruit yield and quality

    Directory of Open Access Journals (Sweden)

    Luigi Morra

    2016-08-01

    Full Text Available Two trials in different agricultural farms were carried out from October 2014 to June 2015 with the aim to assess the advantages linked to the substitution of the low density polyethylene (LDPE films for soil mulching with the Mater-Bi® biodegradable films in the strawberry cultivation under tunnel in Campania. Lifetime of biodegradable mulch and influence of type of mulch on the yield and the quality of cvs Sabrina and Fortuna were evaluated. Plants were cultivated on mulched, raised beds, high 40 cm from bottom soil. Mater-Bi® film was 20 µm thick while LDPE film was 50 mm thick. The physical-chemical parameters (firmness, pH, total soluble solid content, titratable acidity and skin colour and some bioactive compounds (total polyphenols, flavonoids, anthocyanins, antioxidant activity of fruits were determined by three samplings effected in consecutive months (from March to May 2015 of the harvest cycle. Biodegradable film guaranteed an effective mulch along the whole strawberry cycle (9-10 months including the time of drawing up of film. Yields of cv Sabrina on LDPE was 18% higher than those on Mater-Bi® while the opposite was detected in cv Fortuna (+10%. The physical-chemical parameters of fruits were not modified by the mulches. The content of the bioactive compounds, instead, resulted, in each time of sampling, significantly higher in fruits picked on Mater-Bi® based film.

  17. Work Domain Analysis of a Predecessor Sodium-cooled Reactor as Baseline for AdvSMR Operational Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Ronald Farris; David Gertman; Jacques Hugo

    2014-03-01

    This report presents the results of the Work Domain Analysis for the Experimental Breeder Reactor (EBR-II). This is part of the phase of the research designed to incorporate Cognitive Work Analysis in the development of a framework for the formalization of an Operational Concept (OpsCon) for Advanced Small Modular Reactors (AdvSMRs). For a new AdvSMR design, information obtained through Cognitive Work Analysis, combined with human performance criteria, can and should be used in during the operational phase of a plant to assess the crew performance aspects associated with identified AdvSMR operational concepts. The main objective of this phase was to develop an analytical and descriptive framework that will help systems and human factors engineers to understand the design and operational requirements of the emerging generation of small, advanced, multi-modular reactors. Using EBR-II as a predecessor to emerging sodium-cooled reactor designs required the application of a method suitable to the structured and systematic analysis of the plant to assist in identifying key features of the work associated with it and to clarify the operational and other constraints. The analysis included the identification and description of operating scenarios that were considered characteristic of this type of nuclear power plant. This is an invaluable aspect of Operational Concept development since it typically reveals aspects of future plant configurations that will have an impact on operations. These include, for example, the effect of core design, different coolants, reactor-to-power conversion unit ratios, modular plant layout, modular versus central control rooms, plant siting, and many more. Multi-modular plants in particular are expected to have a significant impact on overall OpsCon in general, and human performance in particular. To support unconventional modes of operation, the modern control room of a multi-module plant would typically require advanced HSIs that would

  18. Research Status of the Artiifcial Dura Mater%人工硬脑膜材料的研究现状

    Institute of Scientific and Technical Information of China (English)

    张宇杭; 胥光申

    2016-01-01

    在神经外科手术中,硬脑膜替代物对于维持解剖学的完整和脑组织保护是十分重要的。近年来,随着组织工程和生物材料研究技术的发展,人工硬脑膜的研究取得许多进展。本文对人工硬脑膜国内外的相关文献进行了检索和综合分析,并展望了未来人工硬脑膜研究重点和发展方向。%Dura mater substitutes are of great importance in keeping anatomies intact and protecting brain tissue in neurosurgical operations. With the continuous development of tissue engineering and biomaterials in recent years, the research progress of the artiifcial dural materials has made remarkable progress. In this paper, the related literature about dura mater both at home and abroad were searched and analyzed comprehensively. The paper also examined the prospect of the focus and development direction of dura mater in the future research.

  19. Preliminary exploration of the development of a collagenous artificial dura mater for sustained antibiotic release

    Institute of Scientific and Technical Information of China (English)

    WANG Hao; DONG Hui; KANG Cheng-gui; LIN Cheng; YE Xun; ZHAO Yuan-li

    2013-01-01

    Background Intracranial infection is one of the most common complications of open craniocerebral injury and of conventional craniotomy in neurosurgery.The presence of blood-brain barrier leads to lower drug concentrations in the cerebrospinal fluid than in the venous blood.Increasing the intravenous dosage or frequency carries the risk of systemic adverse reactions or infections in other parts of the body.Developing an artificial dura mater (ADM) for sustained antibiotic release for use during neurosurgery can solve the problems perfectly.Methods Three types of drug-loaded ADMs made of collagen and containing cefuroxime sodium,ceftriaxone sodium,or norvancomycin were prepared.The antibacterial activity and sustained release characteristics of the ADMs were examined using bacteriostatic and release tests.Results Single-layered collagen based ADMs (40 mm×50 mm×5 mm) containing 18 mg cefuroxime sodium or ceftriaxone sodium were not suitable for continued development because of drug preservation and stability issues.Using smaller ADMs (20 mm×30 mm×7 mm),containing 4.86 mg of norvancomycin,with increased collagen density and a three-layered film with two outer drug-free films above and below the antibiotic layer resulted in sustained cumulative release of 2.91 mg (59.9%) of norvancomycin over 72 hours.The similar factor (f2) comparison method proved that products from a same batch were statistically significant similar (f2 >50).Conclusions Artificial ADMs made of collagen can be processed to provide a mature dural repair material for the sustained release of norvancomycin.This system may provide a basis for developing sustained release materials for other drugs.

  20. Idiopathic spinal cord herniation with duplicated dura mater and dorsal subarachnoid septum. Report of a case and review of the literature

    Science.gov (United States)

    Yamamoto, Norio; Higashino, Kousaku; Sairyo, Koichi

    2014-01-01

    Background Idiopathic spinal cord herniation (ISCH) is a rare condition and its pathogenesis remains unclear. The purpose of this case report is to present an ISCH case with dorsal subarachnoid septum suggesting the pathogenesis of ISCH being adhesions from preexisting inflammation. Methods Single case report. Results A 60-year-old woman presented with Brown-Séquard syndrome below the level of T6. Magnetic resonance imaging revealed the thoracic spinal cord was displaced ventrally, and the dorsal subarachnoid space was enlarged and had a septum between the spinal cord and dura mater. Intraoperatively, the dorsal dura mater was seen to be adherent and the subarachnoid septum was identified after durotomy. The inner layer defect of the duplicated dura mater was found in the ventral dura mater, through which the spinal cord had herniated. After releasing the septum, the adhesions around the dura mater, and the hiatus, the spinal cord was reduced. Conclusions The present case indicates that adhesions around the dura mater can be the pathogenesis of ISCH. PMID:25694934

  1. Laser bonding with ICG-infused chitosan patches: preliminary experiences in suine dura mater and vocal folds

    Science.gov (United States)

    Rossi, Francesca; Matteini, Paolo; Ratto, Fulvio; Pini, Roberto; Iacoangeli, Maurizio; Giannoni, Luca; Fortuna, Damiano; Di Cicco, Emiliano; Corbara, Sylwia; Dallari, Stefano

    2014-05-01

    Laser bonding is a promising minimally invasive approach, emerging as a valid alternative to conventional suturing techniques. It shows widely demonstrated advantages in wound treatment: immediate closuring effect, minimal inflammatory response and scar formation, reduced healing time. This laser based technique can overcome the difficulties in working through narrow surgical corridors (e.g. the modern "key-hole" surgery as well as the endoscopy setting) or in thin tissues that are impossible to treat with staples and/or stitches. We recently proposed the use of chitosan matrices, stained with conventional chromophores, to be used in laser bonding of vascular tissue. In this work we propose the same procedure to perform laser bonding of vocal folds and dura mater repair. Laser bonding of vocal folds is proposed to avoid the development of adhesions (synechiae), after conventional or CO2 laser surgery. Laser bonding application in neurosurgery is proposed for the treatment of dural defects being the Cerebro Spinal Fluid leaks still a major issue. Vocal folds and dura mater were harvested from 9-months old porks and used in the experimental sessions within 4 hours after sacrifice. In vocal folds treatment, an IdocyanineGreen-infused chitosan patch was applied onto the anterior commissure, while the dura mater was previously incised and then bonded. A diode laser emitting at 810 nm, equipped with a 600 μm diameter optical fiber was used to weld the patch onto the tissue, by delivering single laser spots to induce local patch/tissue adhesion. The result is an immediate adhesion of the patch to the tissue. Standard histology was performed, in order to study the induced photothermal effect at the bonding sites. This preliminary experimental activity shows the advantages of the proposed technique in respect to standard surgery: simplification of the procedure; decreased foreign-body reaction; reduced inflammatory response; reduced operating times and better handling in

  2. Biological Effects of Clinically Relevant CoCr Nanoparticles in the Dura Mater: An Organ Culture Study

    Directory of Open Access Journals (Sweden)

    Iraklis Papageorgiou

    2014-06-01

    Full Text Available Medical interventions for the treatment of spinal disc degeneration include total disc replacement and fusion devices. There are, however, concerns regarding the generation of wear particles by these devices, the majority of which are in the nanometre sized range with the potential to cause adverse biological effects in the surrounding tissues. The aims of this study were to develop an organ culture model of the porcine dura mater and to investigate the biological effects of CoCr nanoparticles in this model. A range of histological techniques were used to analyse the structure of the tissue in the organ culture. The biological effects of the CoCr wear particles and the subsequent structural changes were assessed using tissue viability assays, cytokine assays, histology, immunohistochemistry, and TEM imaging. The physiological structure of the dura mater remained unchanged during the seven days of in vitro culture. There was no significant loss of cell viability. After exposure of the organ culture to CoCr nanoparticles, there was significant loosening of the epithelial layer, as well as the underlying collagen matrix. TEM imaging confirmed these structural alterations. These structural alterations were attributed to the production of MMP-1, -3, -9, -13, and TIMP-1. ELISA analysis revealed that there was significant release of cytokines including IL-8, IL-6, TNF-α, ECP and also the matrix protein, tenascin-C. This study suggested that CoCr nanoparticles did not cause cytotoxicity in the dura mater but they caused significant alterations to its structural integrity that could lead to significant secondary effects due to nanoparticle penetration, such as inflammation to the local neural tissue.

  3. Visualisation of the intact dura mater and brain surface in infant autopsies: a minimally destructive technique for the post-mortem assessment of head injury.

    Science.gov (United States)

    Cheshire, Emma C; Malcomson, Roger D G; Rutty, Guy N; James, Deryk S

    2015-03-01

    During the post-mortem examination of babies and young children, it is important to be able to visualise the brain and its coverings, particularly in cases where a head injury is likely to have occurred. In this paper, we present an improved method for removal of the calvarial bones in infant autopsies to enable viewing of the dura mater and brain. In contrast to the standard post-mortem procedure for observing and removing the brain, this novel technique is minimally disruptive, allowing the dura mater to remain undamaged. Specialised paediatric neurosurgical tools were used to remove the skull bones from 23 neonates, infants and young children during post-mortem examination. In 21 of our 23 cases, the calvarial bones were removed successfully with the dura mater remaining intact. In one case, there was a thickening of the dura mater which created a strong adherence of this membrane to the bone. In another case, the dura mater was slightly damaged due to the inexperience of the operator in using the neurosurgical tools. This method of calvarial bone removal reduces the degree of post-mortem artefact and enhances the ability to observe and photographically document autopsy findings, including the artefact-free detection of signs of injury such as epidural or subdural haematoma, and brain swelling. This technique has now become a routine practise in both of our units to remove the skull bones in infant/young children post-mortem examinations.

  4. Impact of holmium fibre laser radiation (λ = 2.1 μm) on the spinal cord dura mater and adipose tissue

    Science.gov (United States)

    Filatova, S. A.; Kamynin, V. A.; Ryabova, A. V.; Loshchenov, V. B.; Zelenkov, P. V.; Zolotovskii, I. O.; Tsvetkov, V. B.; Kurkov, A. S.

    2015-08-01

    The impact of holmium fibre laser radiation on the samples of biologic tissues (dura mater of spinal cord and adipose tissue with interlayers of muscle) is studied. The experimental results are evaluated by the size of carbonisation and coagulation necrosis zones. The experiment shows that in the case of irradiation of the spinal cord dura mater samples the size of carbonisation and coagulation necrosis zones is insignificant. In the adipose tissue the carbonisation zone is also insignificant, but the region of cellular structure disturbance is large. In the muscle tissue the situation is opposite. The cw laser operation provides clinically acceptable degree of destruction in tissue samples with a minimal carbonisation zone.

  5. The Thermal Stability of Tertiary Pyridine Resin for the Application to Multi-functional Reprocessing Process - Adv.-ORIENT Cycle Development

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Yoshihiko; Okada, K.; Akiyoshi, M.; Matsunaga, T. [AIST Tsukuba Central 5, Higashi 1-1-1, Tsukuba, Ibaraki 305-8565 (Japan); Suzuki, T. [Tokyo Tech (Japan); Koyama, S.; Ozawa, M. [Japan Atomic Energy Agency - JAEA (Japan)

    2009-06-15

    As part of 'Adv.-ORIENT' (Advanced Optimization by Recycling Instructive Elements) cycle technologies which aim to develop new fuel cycle based on FBR (Fast Breeder Reactor), the fundamental thermochemical properties of tertiary pyridine resin (TPR) and its mixtures with methanol/HCl and HNO{sub 3} were investigated and heating tests on gram scale with TPR/methanol/HNO{sub 3} were carried out in order to evaluate the thermal stability of TPR and to determine the conditions necessary to avoid runaway reactions. It was found that TPR with HCl was thermally stable. Evident thermal decomposition peaks were identified with TPR in the presence of concentrated HNO{sub 3}. No specific effect was observed for methanol involving. However, it was considered that the rapidly exothermic reaction can be controlled by heating temperature. (authors)

  6. Visualization of the network of primo vessels and primo nodes above the pia mater of the brain and spine of rats by using Alcian blue.

    Science.gov (United States)

    Lee, Ho-Sung; Lee, Byung-Cheon

    2012-10-01

    By spraying and injecting Alcian blue into the lateral ventricle, we were able to visualize the network of the nerve primo vascular system above the pia mater of the brain and spine of rats. Staining these novel structures above the pia mater with 4',6-diamidino-2-phenylindole demonstrated that they coexisted in cellular and extracellular DNA forms. The cellular primo node consisted of many cells surrounded by rod-shaped nuclei while the extracellular primo node had a different morphology from that of a general cell in terms of DNA signals, showing granular DNA in a threadlike network of extracellular DNA. Also, differently from F-actin in general cells, the F-actin in the primo vessel was short and rod-shaped. Light and transmission electron microscopic images of the PN showed that the nerve primo vascular system above the pia mater of the brain and spine was a novel dynamic network, suggesting the coexistence of DNA and extracellular DNA. Based on these data, we suggest that a novel dynamic system with a certain function exists above the pia mater of the central nerve system. We also discuss the potential of this novel network system in the brain and spine as related to acupuncture meridians and neural regeneration.

  7. Wrinkling of a stiff thin film bonded to a pre-strained, compliant substrate with finite thickness.

    Science.gov (United States)

    Ma, Yinji; Xue, Yeguang; Jang, Kyung-In; Feng, Xue; Rogers, John A; Huang, Yonggang

    2016-08-01

    A stiff thin film bonded to a pre-strained, compliant substrate wrinkles into a sinusoidal form upon release of the pre-strain. Many analytical models developed for the critical pre-strain for wrinkling assume that the substrate is semi-infinite. This critical pre-strain is actually much smaller than that for a substrate with finite thickness (Ma Y et al. 2016 Adv. Funct. Mater. (doi:10.1002/adfm.201600713)). An analytical solution of the critical pre-strain for a system of a stiff film bonded to a pre-strained, finite-thickness, compliant substrate is obtained, and it agrees well with the finite-element analysis. The finite-thickness effect is significant when the substrate tensile stiffness cannot overwhelm the film tensile stiffness.

  8. Enhanced photovoltaic performance of a dye-sensitized solar cell using graphene-TiO2 photoanode prepared by a novel in situ simultaneous reduction-hydrolysis technique.

    Science.gov (United States)

    Chen, Liang; Zhou, Yong; Tu, Wenguang; Li, Zhengdao; Bao, Chunxiong; Dai, Hui; Yu, Tao; Liu, Jianguo; Zou, Zhigang

    2013-04-21

    Enhanced photovoltaic performance of a DSSC using graphene-TiO2 photoelectrodes prepared by our recent in situ simultaneous reduction-hydrolysis technique (Adv. Funct. Mater., 2012, DOI: 10.1002/adfm.201202349, in press) was achieved. The DSSCs based on the G-TiO2 nanocomposites improved their overall energy conversion efficiency to 7.1%. The results prove that the promoting effect of graphene is strongly dependent on its content; namely, the efficiency of DSSCs increases and then decreases with increasing graphene content in TiO2-graphene composites. Excessive graphene in the nanocomposite leads to a decrease of the light harvest of dye molecules and thus a negative effect on the power conversion efficiency of DSSCs.

  9. Archaeometric analysis of Roman bronze coins from the Magna Mater temple using solid-state voltammetry and electrochemical impedance spectroscopy.

    Science.gov (United States)

    Di Turo, Francesca; Montoya, Noemí; Piquero-Cilla, Joan; De Vito, Caterina; Coletti, Fulvio; Favero, Gabriele; Doménech-Carbó, Antonio

    2017-02-22

    Voltammetry of microparticles (VMP) and electrochemical impedance spectroscopy (EIS) techniques, complemented by SEM-EDX and Raman spectroscopy, were applied to a set of 15 Roman bronze coins and one Tessera from the temple of Magna Mater (Rome, Italy). The archaeological site, dated back between the second half and the end of the 4th century A.D., presented a complicated stratigraphic context. Characteristic voltammetric patterns for cuprite and tenorite for sub-microsamples of the corrosion layers of the coins deposited onto graphite electrodes in contact with 0.10 M HClO4 aqueous solution yielded a grouping of the coins into three main groups. This grouping was confirmed and refined using EIS experiments of the coins immersed in air-saturated mineral water using the reduction of dissolved oxygen as a redox probe. The electrochemical grouping of coins corroborated the complex stratigraphy of the archaeological site and, above all, the reuse of the coins during the later periods due to the economic issues related to the fall of the Roman Empire.

  10. Uncover the mantle: rediscovering Gregório Lopes palette and technique with a study on the painting "Mater Misericordiae"

    Science.gov (United States)

    Antunes, Vanessa; Candeias, António; Oliveira, Maria J.; Carvalho, Maria L.; Dias, Cristina Barrocas; Manhita, Ana; Francisco, Maria J.; Costa, Sónia; Lauw, Alexandra; Manso, Marta

    2016-11-01

    Gregório Lopes (c. 1490-1550) was one of the most prominent painters of the renaissance and Mannerism in Portugal. The painting "Mater Misericordiae" made for the Sesimbra Holy House of Mercy, circa 1535-1538, is one of the most significant works of the artist, and his only painting on this theme, being also one of the most significant Portuguese paintings of sixteenth century. The recent restoration provided the possibility to study materially the painting for the first time, with a multianalytical methodology incorporating portable energy-dispersive X-ray fluorescence spectroscopy, scanning electron microscopy-energy-dispersive spectroscopy, micro-X-ray diffraction, micro-Raman spectroscopy and high-performance liquid chromatography coupled to diode array and mass spectrometry detectors. The analytical study was complemented by infrared reflectography, allowing the study of the underdrawing technique and also by dendrochronology to confirm the date of the wooden panels (1535-1538). The results of this study were compared with previous ones on the painter's workshop, and significant differences and similitudes were found in the materials and techniques used.

  11. Impact of holmium fibre laser radiation (λ = 2.1 μm) on the spinal cord dura mater and adipose tissue

    Energy Technology Data Exchange (ETDEWEB)

    Filatova, S A; Kamynin, V A; Ryabova, A V; Loshchenov, V B; Tsvetkov, V B; Kurkov, A S [A M Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation); Zelenkov, P V [N. N. Burdenko Scientific Research Neurosurgery Institute, Moscow (Russian Federation); Zolotovskii, I O [Ulyanovsk State University, Ulyanovsk (Russian Federation)

    2015-08-31

    The impact of holmium fibre laser radiation on the samples of biologic tissues (dura mater of spinal cord and adipose tissue with interlayers of muscle) is studied. The experimental results are evaluated by the size of carbonisation and coagulation necrosis zones. The experiment shows that in the case of irradiation of the spinal cord dura mater samples the size of carbonisation and coagulation necrosis zones is insignificant. In the adipose tissue the carbonisation zone is also insignificant, but the region of cellular structure disturbance is large. In the muscle tissue the situation is opposite. The cw laser operation provides clinically acceptable degree of destruction in tissue samples with a minimal carbonisation zone. (laser applications in medicine)

  12. Stimulation of rat cranial dura mater with potassium chloride causes CGRP release into the cerebrospinal fluid and increases medullary blood flow.

    Science.gov (United States)

    Dux, Mária; Will, Christine; Eberhardt, Mirjam; Fischer, Michael J M; Messlinger, Karl

    2017-02-10

    Primary headaches may be accompanied by increased intracranial blood flow induced by the release of the potent vasodilator calcitonin gene-related peptide (CGRP) from activated meningeal afferents. We aimed to record meningeal and medullary blood flow simultaneously and to localize the sites of CGRP release in rodent preparations in vivo and ex vivo. Blood flow in the exposed rat parietal dura mater and the medulla oblongata was recorded by laser Doppler flowmetry, while the dura was stimulated by topical application of 60mM potassium chloride (KCl). Samples of jugular venous plasma and cerebrospinal fluid (CSF) collected from the cisterna magna were analysed for CGRP concentrations using an enzyme immunoassay. In a hemisected rat skull preparation lined with dura mater the CGRP releasing effect of KCl superfusion was examined. Superfusion of the dura mater with KCl decreased meningeal blood flow unless alpha-adrenoceptors were blocked by phentolamine, whereas the medullary blood flow was increased. The same treatment caused increased CGRP concentrations in jugular plasma and CSF and induced significant CGRP release in the hemisected rat skull preparation. Anaesthesia of the trigeminal ganglion by injection of lidocaine reduced increases in medullary blood flow and CGRP concentration in the CSF upon meningeal KCl application. CGRP release evoked by depolarisation of meningeal afferents is accompanied by increased blood flow in the medulla oblongata but not the dura mater. This discrepancy can be explained by the smooth muscle depolarising effect of KCl and the activation of sympathetic vasoconstrictor mechanisms. The medullary blood flow response is most likely mediated by CGRP released from activated central terminals of trigeminal afferents. Increased blood supply of the medulla oblongata and CGRP release into the CSF may also occur in headaches accompanying vigorous activation of meningeal afferents.

  13. The Effects of 910-MHz Electromagnetic Field on Rat Cranial Arachnoid and Dura Mater Collagen. The Axial Periodicity of Collagen Fibrils

    Directory of Open Access Journals (Sweden)

    Margaret Tzaphlidou

    2004-01-01

    Full Text Available The axial periodicity of rat arachnoid and dura mater collagen fibrils exposed to 910 MHz for 2 h/day for 30 consecutive days was measured by means of image analysis of electron-optical data. Such measurements were compared with those from sham-exposed animals. These measurements reveal that on exposure, the intermolecular interactions during collagen fibril assembly are affected.

  14. Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain

    Institute of Scientific and Technical Information of China (English)

    Ho-Sung Lee; Dai-In Kang; Seung Zhoo Yoon; Yeon Hee Ryu; Inhyung Lee; Hoon-Gi Kim; Byung-Cheon Lee; Ki Bog Lee

    2015-01-01

    With chromium-hematoxylin staining, we found evidence for the existence of novel age-depen-dent network structures in the dura mater of rat brains. Under stereomicroscopy, we noticed that chromium-hematoxylin-stained threadlike structures, which were barely observable in 1-week-old rats, were networked in specific areas of the brain, for example, the lateral lobes and the cerebella, in 4-week-old rats. In 7-week-old rats, those structures were found to have become larger and better networked. With phase contrast microscopy, we found that in 1-week-old rats, chromium-hematoxylin-stained granules were scattered in the same areas of the brain in which the network structures would later be observed in the 4- and 7-week-old rats. Such age-depen-dent network structures were examined by using optical and transmission electron microscopy, and the following results were obtained. The scattered granules fused into networks with increas-ing age. Cross-sections of the age-dependent network structures demonstrated heavily-stained basophilic substructures. Transmission electron microscopy revealed the basophilic substructures to be clusters with high electron densities consisting of nanosized particles. We report these data as evidence for the existence of age-dependent network structures in the dura mater, we discuss their putative functions of age-dependent network structures beyond the general concept of the dura mater as a supporting matrix.

  15. Pulsed estrogen therapy prevents post-OVX porcine dura mater microvascular network weakening via a PDGF-BB-dependent mechanism.

    Directory of Open Access Journals (Sweden)

    Olga V Glinskii

    Full Text Available In postmenopausal women, estrogen (E2 deficiencies are frequently associated with higher risk of intracranial hemorrhage, increased incidence of stroke, cerebral aneurysm, and decline in cognitive abilities. In younger postpartum women and those using oral contraceptives, perturbations in E2 are associated with higher risk of cerebral venous thrombosis. A number of serious intracranial pathologic conditions linked to E2 deficiencies, such as dural sinus thrombosis, dural fistulae, non-parenchymal intracranial hemorrhages, migraines, and spontaneous cerebrospinal fluid leaks, involve the vessels not of the brain itself, but of the outer fibrous membrane of the brain, the dura mater (DM. The pathogenesis of these disorders remains mysterious and how estrogen regulates structural and functional integrity of DM vasculature is largely unknown. Here, we demonstrate that post ovariectomy (OVX DM vascular remodeling is manifested by microvessel destabilization, capillary rarefaction, increased vascular permeability, and aberrant angio-architecture, and is the result of disrupted E2-regulated PDGF-BB signaling within dura microvasculature. These changes, associated with the reduction in systemic PDGF-BB levels, are not corrected by a flat-dose E2 hormone replacement therapy (HRT, but are largely prevented using HRT schedules mimicking physiological E2 fluctuations. We demonstrate that 1 E2 regulates PDGF-BB production by endothelial cells in a dose-dependent manner and 2 optimization of PDGF-BB levels and induction of robust PDGF-mediated endothelial cell-vascular pericyte interactions require high (estrous E2 concentrations. We conclude that high (estrous levels of E2 are important in controlling PDGF-mediated crosstalk between endothelial cells and pericytes, a fundamental mechanism governing microvessel stability and essential for preserving intracranial homeostasis.

  16. The "RESEAU MATER": An efficient infection control for endometritis, but not for urinary tract infection after vaginal delivery.

    Science.gov (United States)

    Ayzac, Louis; Caillat-Vallet, Emmanuelle; Girard, Raphaële; Berland, Michel

    2016-09-01

    "RESEAU MATER" is useful to monitor nosocomial infections in maternity and contributes to the decreasing trend of it, since its implementation. Specifically, this network demonstrates its efficiency in the control of endometritis following vaginal deliveries, but not in the control of urinary tract infections. The aim of this study is to determine whether the difference between the control of endometritis and of urinary tract infection could be explained by an unsuitable regression model or by an unsuitable care policy concerning urinary cares. This study includes (1) the analysis of historic data of the network and (2) the description of French guidelines for maternity cares and available evaluations, concerning endometritis and urinary tract infection prevention. Univariate and multivariate odds ratios (ORs) were calculated for the total study period of 1999-2013, for these infections and their risk factors. The endometritis frequency is decreasing, in association with no significant evolution of associated risk factors, but urinary tract infection frequency is constant, in association with a increasing trend of its risk factors such as intermittent catheterization and epidural analgesia. In French guidelines, all preventive measures against endometritis are clearly broadcasted by all field operators, and repeated audits have reinforced the control of their application. But preventive measures against urinary tract infection seem to be broadcasted exclusively in the circle of infection prevention agencies and not in the obstetrics societies or in the Health Ministry communication. Urinary tract infection prevention requires a clearer public and professional policy in favor of a more efficient urinary cares, with a specific target to maternity.

  17. Permeability of dura mater

    DEFF Research Database (Denmark)

    Tfelt-Hansen, Peer Carsten

    2011-01-01

    In the wake of cortical spreading depression (CSD) it has been suggested that noxious substances diffuse through the dura with resulting firing of epidural nerves. In my view this is unlikely because there are good reasons to suggest that there must be a dura-brain barrier. Alternatively collater...

  18. Nociceptive behaviors were induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats and reduced by morphine and rizatriptan benzoate.

    Science.gov (United States)

    Dong, Zhao; Jiang, Lei; Wang, Xiaohui; Wang, Xiaolin; Yu, Shengyuan

    2011-01-12

    The trigeminovascular nociception induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in anesthetized animals has been widely used as a model for investigation of the pathophysiology of vascular headache such as migraine. However, little is known whether pain behaviors can be induced using this model in conscious animals. Thus, to establish a new model of trigeminovascular nociception in conscious animals and to examine the effects of morphine and rizatriptan benzoate on nociceptive behaviors in this new model, we electrically stimulated the dura mater surrounding the superior sagittal sinus. We found that grooming and head-flick activities were altered partially in a frequency-dependent way and that frequencies ranging from 10 to 20 Hz more easily provoked these behaviors. Moreover, we also demonstrated that these behaviors were reduced by morphine and rizatriptan benzoate. Thus, this new model will provide a useful and appropriate tool to directly assess changes in the intensity of pain for further investigation of pathophysiological mechanisms of migraine in conscious animals.

  19. The Correlations of Educational Service,Perceived College Support and College Students’ Commitment to Alma Mater%大学生母校承诺的心理结构及其影响因素研究

    Institute of Scientific and Technical Information of China (English)

    陈志霞; 张敏

    2014-01-01

    母校承诺是指大学生对母校的心理认同和情感依恋,培养大学生对母校的积极情感,是大学生情感教育的重要构成部分。研究结果表明:大学生母校承诺的心理结构包含认知承诺、感情承诺和责任承诺三个部分,高校教育服务质量通过母校支持感的部分中介作用对大学生母校承诺发挥积极影响。因此,高校应从认知、情感和责任三维角度来加强对学生母校情感的综合培养,通过提高高校教育服务质量和学生的母校支持感进而增强其母校承诺。%Commitment to Alma Mater is a kind of psychological identification and emotional attachment for Alma Mater of college students. The structure and mechanism of college students ’ commitment to Alma Mater are analyzed through both theoretical analysis and empirical research. The results are as follows:Commitment to Alma Mater is composed of three factors:cognitive commitment,affective commitment and obligation commitment, and students’ perceived college support plays a partially intermediary role in the relationship between the quality of college’s education and service and college students’ commitment to Alma Mater. In order to improve college students ’ commitment to Alma Mater , colleges and universities should educate college students ’ affection to Alma Mater from cognitive,affective,responsible aspects and improve the commitment to Alma Mater through enhancing the quality of college’s education and service and the perceived college support.

  20. Research on Power System State Monitoring Communication for BATMAN-adv Improvement%改进BATMAN-adv的电力系统状态监测通信研究

    Institute of Scientific and Technical Information of China (English)

    陈东升; 戴和原

    2016-01-01

    随着无线通信在电力物联网监测中的广泛应用,电网中各环节状态参数类型的多样化直接导致了传输网络中传输业务的增加,对通信网络的吞吐量和稳定性提出了较高的要求.基于BATMAN-adv(Better Approach to Mobile Ad-hoc Networking Advanced)的无线Mesh网络通过对多网卡Mesh协议的支持,解决了无线Mesh网络多跳衰减的问题.文章针对BATMAN-adv Mesh路由选择标准唯一而导致的路由选择正确率和带宽下降问题,提出了一种智能链路选取方案,利用数据发送速率阈值改进路由协议标准.实际应用表明,改进BATMAN-adv可有效提高网络传输性能,对电力系统中的状态监测系统的稳定性具有重大的实际意义.

  1. The Fos expression in rat brain following electrical stimulation of dura mater surrounding the superior sagittal sinus changed with the pre-treatment of rizatriptan benzoate.

    Science.gov (United States)

    Wang, Xiaolin; Yu, Shengyuan; Dong, Zhao; Jiang, Lei

    2011-01-07

    Fos expression in the brain was systematically investigated by means of immunohistochemical staining after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious rats. Fos-like immunoreactive neurons are distributed mainly in the upper cervical spinal cord, spinal trigeminal nucleus caudal part, raphe magnus nucleus, periaqueductal gray, ventromedial hypothalamic nucleus, and mediodorsal thalamus nucleus. With the pre-treatment of intraperitoneal injection of rizatriptan benzoate, the number of Fos-like immunoreactive neurons decreased in the spinal trigeminal nucleus caudal part and raphe magnus nucleus, increased in the periaqueductal gray, and remained unchanged in the ventromedial hypothalamic nucleus and mediodorsal thalamus nucleus. These results provide morphological evidence that the nuclei described above are involved in the development and maintenance of the trigeminovascular headache.

  2. On the Cultivation of Students' Sense of the Love for the Alma Mater during Higher Education%培养学生爱校情怀在高等教育中的作用和途径

    Institute of Scientific and Technical Information of China (English)

    赵慧

    2011-01-01

    The survey from MyCOS shows that the graduates from colleges and universities are not willing to recommend their alma mater to the public at present.In order to increase the students' acceptability of their alma mater,colleges and universities should not only make a great effort to do a good job in other aspects,but also focus on the cultivation of students' sense of the love for the alma mater in the process of higher education.The thesis mainly indicates the cultivation of students' sense of the love for the alma mater from the following three points.%麦可思公司的调查结果显示,目前各类高校的毕业生对母校的推荐度普遍较低。要提高学生对学校的认可度,高校在努力做好其它各项工作的同时,应该把大学生爱校情怀的培养贯穿于高等教育的始终。可以通过抓住新生入学契机,加强培养学生爱校情怀,搭建学生爱校情怀的平台,注重学生的毕业教育等三条途径现实对大学生爱校情怀的培养。

  3. 硬脊膜完整性可影响脑脊液中细胞因子的水平☆%Dura mater spinalis integrity may influence cytokine levels in the cerebrospinal fluid

    Institute of Scientific and Technical Information of China (English)

    白万山; 王新伟; 袁文; 王占超; 梁磊; 王会学

    2013-01-01

    BACKGROUND:Pathophysiological mechanisms after spinal cord injury are very complex, so there is no compressive and in-depth understanding on it. OBJECTIVE:To study the effect of dura mater spinalis integrity on cytokine levels in the cerebrospinal fluid of animal models of spinal cord injury. METHODS:The white rabbit models of spinal cord injury were established using clamp compression method, and then the models were randomly divided into four groups:no dura mater spinalis defect group, dura mater spinalis defect group, dura mater spinalis defect composite with membrane repairing group and dura mater spinalis defect composite with autologous fascia repair group. Enzyme-linked immunosorbent assay was performed to detect the changes of levels of cytokines (interleukin-6, interleukin-10 and tumor necrosis factorα) in the cerebrospinal fluid at 30 minutes, 1, 3, 6, 12 and 36 hours after surgery. RESULTS AND CONCLUSION:The levels of interleukin-6, interleukin-10 and tumor necrosis factorαin the cerebrospinal fluid of the dura mater spinalis defect group, dura mater spinalis defect composite with membrane repairing group and dura mater spinalis defect composite with autologous fascia repair group were significantly lower than those of the no dura mater spinalis defect group at 6 hours after surgery (P0.05). The results indicate that maintaining the integrity of dura mater spinalis of the spinal cord injury model can affect the levels of interleukin-6, interleukin-10 and tumor necrosis factorαin the cerebrospinal fluid, thus inhibiting the inflammatory response.%  背景:脊髓损伤后的病理生理机制非常复杂,人们对此认识还很不全面、深入。目的:观察脊髓损伤动物模型中硬脊膜完整性对脑脊液内细胞因子水平的影响。  方法:采用钳夹压迫法建立新西兰大白兔脊髓损伤模型,随机分为无硬脊膜缺损组、硬脊膜缺损组、硬脊膜缺损复合膜修复组、硬脊膜缺损

  4. O problema da classificação do item “onde”: advérbio ou pronome? = The problematic classification of the term where. is it an adverb or a pronoun?

    Directory of Open Access Journals (Sweden)

    Adriana dos Santos Souza

    2010-07-01

    Full Text Available Muitos trabalhos têm sido desenvolvidos a partir do item “onde”, dada a diversidade de usos que a ele são atribuídos. Face a esse fato, deparamo-nos ainda com as discussões acerca da classe gramatical na qual, tradicionalmente, insere-se o referido termo: os advérbios. Discutem-se aqui alguns pontos importantes sobre eles, como a definição tradicional, as questões históricas que permeiam essa conceituação, os problemas associados a essa tradição, além de serem apresentadas outras definições que se pautam em estudos de caráter funcionalista. A partir desse esboço, apresentamos a literatura relacionada ao onde, descrevendo a origem, as possíveis classificações morfossintáticas (advérbio/pronome e algumas acepções a ele atribuídas por diversos pesquisadores, a partir de pesquisas comcorpora de sincronias distintas.Owing to different uses assigned to the term, where has been the object of several studies. Investigations have also been made on issues with regard to its grammatical class, the adverbs, in which traditionally the term has been inserted. Important issues are raised on the adverbs, among which the traditional definition, the historical issues that pervade its concept, the problems associated with this tradition and other definitions based on functional studies. The literature related to the term where is provided, coupled to a description of its origin, its possible morphological and syntactical classifications (adverb/pronoun and some stances attributed to it by researchers as from discussions with distinct synchronies corpora.

  5. Effect of Ce doping on the electrocaloric effect of Sr{sub x}Ba{sub 1−x}Nb{sub 2}O{sub 6} single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Le Goupil, Florian, E-mail: f.le-goupil09@imperial.ac.uk; Berenov, Andrey; Alford, Neil McN. [Department of Materials, Imperial College London, London SW7 2AZ (United Kingdom); Axelsson, Anna-Karin [Department of Materials, Imperial College London, London SW7 2AZ (United Kingdom); Department of Engineering Systems, London South Bank University, London SE1 0AA (United Kingdom); Valant, Matjaz [Materials Research Laboratory, University of Nova Gorica, Nova Gorica 5000 (Slovenia); Lukasiewicz, Tadeusz [Insitute of Electronic Materials Technology, 133 Wolczynska St., 01-919 Warsaw (Poland); Dec, Jan [Institute of Materials Science, University of Silesia, 12 Bankowa St., PL 40-007 Katowice (Poland)

    2014-06-02

    The electrocaloric effect (ECE) of Sr{sub x}Ba{sub (1−x)}Nb{sub 2}O{sub 6} (SBN100x) single crystals, with a tetragonal tungsten bronze structure and a high ECE near room temperature, is studied by direct measurements. It is shown that although the onset of the ECE peak is closer to room temperature in SBN80 than in SBN75, the effect of the increase of the strontium content is very detrimental to the ECE performances with a decrease to ΔT{sub EC} = 0.23 K for SBN80 from the reported value of ΔT{sub EC} = 0.42 K under 10 kV/cm for SBN75 [F. Le Goupil et al., “Anisotropy of the electrocaloric effect in lead-free relaxor ferroelectrics,” Adv. Energy Mater. (published online)]. However, when 1.40% of cerium is introduced in SBN61, the temperature of depolarisation is shifted below 30 °C, while an ECE above 0.6 K is maintained over more than 70 K for a low electric field of 28 kV/cm. The maximum ECE ΔT{sub EC} = 0.85 K is measured at 61 °C. In addition to having an ECE peak close to room temperature, the ECE measured in Ce-doped SBN61 is comparable with the best reported values for lead-free materials [Y. Bai et al., J. Appl. Phys. 110, 094103 (2011); X.-S. Qian et al., Adv. Funct. Mater. 24, 1300 (2014)], when linearly extrapolated to higher electric fields.

  6. Effects of variation of chitosan concentration on the characteristics of membrane cellulose bacteria-chitosan biocomposites as candidates for artificial dura mater

    Science.gov (United States)

    Widiyanti, Prihartini; Jabbar, Hajria; Rudyardjo, Djony Izak

    2017-02-01

    This study was conducted to determine the effect of variation in concentration of chitosan on the physical and biological characteristics of the membrane of bacterial cellulose-chitosan biocomposites through immersion precipitation method. Bacterial cellulose membrane was soaked in a solution of chitosan whose concentration variation are 0.1%; 0.3%; 0.5% and 0.7%. The characterization tests which were conducted included the analysis of functional groups (FTIR), tensile strength test, morphology test (SEM), and cytotoxicity assay using MTT Assay method. Based on the cluster analysis test, the results of FTIR spectra indicate changes in the physical bond which means that there is interaction between the bacterial cellulose membrane with chitosan on each sample. The bacteria produced cellulose membrane with tensile strength of 10.53 ± 0.19 MPa while the microbial cellulose membrane by adding 0.5% chitosan concentration had tensile strength value of 8:58 ± 0.19 MPa. It shows that with the addition of chitosan it would decrease the tensile strength in microbial cellulose membrane. This was shown by 496.2 nm - 2,032 µm pore size with a thickness (mm) of 0:35 ± 0.33 to 0.81 ± 0.26. Based on the test results of the analysis of functional groups, tensile strength test, and morphology test, membrane microbial cellulose-chitosan biocomposites have the potential to be used as artificial dura mater candidate.

  7. Experimental study on bone marrow mesenchymal stem cell transfected by Adv-HO-1%腺病毒介导hHO-1基因体外转染骨髓间充质干细胞

    Institute of Scientific and Technical Information of China (English)

    马粉娜; 林国生; 曾彬

    2009-01-01

    目的 以腺病毒(adenovirus.Adv)为载体将人血红素加氧酶(human hemo-oxygenase,hHO)-1基因转染至骨髓间充质干细胞(MSC)中,为干细胞移植联合hHO-1基因治疗心血管疾病奠定实验基础.方法 以密度梯度离心结合贴壁筛选法分离培养骨髓MSC.将携带有hHO-1基凶与绿色荧光蛋白(GFP)报告基因的腺病毒体外扩增与鉴定后,以不同感染复数(multiplicity ofinfection,MOI)转染MSC.在荧光显微镜下观察转染后CFP的表达,以反转录(RT)-聚合酶链式反应(PCR)法检测目的 基因hHO-1 mRNA在MSC中的表达,4'6'-二乙酰基-2-苯基吲哚(DA-PU染色观察hHO-1基因转染对MSC的影响.结果 将Adv-hHO-1体外扩增、纯化后,经PCR鉴定可得到555 bp的目的 条带.转染后24 h,MSC中即可见GFP的表达,荧光强度随MOI的增加而增强.RT-PCR法检测显示,不同MOI的转染组均有hHO-1 mRNA表达,随MOI的增加其表达强度也逐渐增强(P<0.05).DAPI染色显示,hHO-1基因转染后,细胞的生长及形态无明显变化.结论 以Adv为载体可成功地将hHO-1基因转染至骨髓MSC中,转染效率随转染滴度的增加而增加,转染后对细胞的牛物学活性尤明显影响.

  8. Microarray analysis of gene expression after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats

    Institute of Scientific and Technical Information of China (English)

    Jiang Lei; Dong Zhao; Li Fengpeng; Liu Ruozhuo; Qiu Enchao; Wang Xiaolin; Yu Shengyuan

    2014-01-01

    Background The molecular and cellular origins of migraine headache are among the most complex problems in contemporary neurology.Up to now the pathogenesis of migraine still remains unclearly defined.The objective of this study was to explore new factors that may be related to the mechanism of migraine.Methods The present study performed a comprehensive analysis of gene expression in the trigeminal nucleus caudalis induced by electrical stimulation of dura mater surrounding the superior sagittal sinus in conscious rats using microarray analysis followed by quantitative real-time reverse-transcribed polymerase chain reaction (qRT-PCR) verification.Student's two sample t-test was employed when two groups were compared.A P value <0.05 was considered to be statistically significant.Results Comparing the placebo and the electrical stimulation groups,40 genes were determined to be significantly differentially expressed.These significantly differentially expressed genes were involved in many pathways,including transporter activity,tryptophan metabolism,G protein signaling,kinase activity,actin binding,signal transducer activity,anion transport,protein folding,enzyme inhibitor activity,coenzyme metabolism,binding,ion transport,cell adhesion,metal ion transport,oxidoreductase activity,mitochondrion function,and others.Most of the genes were involved in more than 2 pathways.Of particular interest is the up-regulation of Phactr3 and Akap5 and the down-regulation of Kdr.Conclusion These findings may provide important clues for a better understanding of the molecular mechanism of migraine.

  9. Alma mater eksponeerib / Kaire Nurk

    Index Scriptorium Estoniae

    Nurk, Kaire, 1960-

    2004-01-01

    Tiit Pääsukese "Maalid" Tartu Ülikooli Y-galeriis 2.-21. III, galeriist (galerist Margus Kiis). Näitus "Põletatud savi - antiigist tänapäevani" TÜ kunstimuuseumis (Berliini Antikensammlungi antiikvaasid, 17 eesti keraamiku antiigiteemalised taiesed) kuni 30. III, kuraatorid Inge Kukk, Airi Ligi, kujundaja Silver Vahtre

  10. 75 FR 49233 - Amendments to Form ADV

    Science.gov (United States)

    2010-08-12

    ...''); comment letter of the Financial Planning Association (May 16, 2008) (``FPA Letter''); Fried Frank Letter... Management Company/USAA Financial Planning Services Insurance Agency, Inc. (May 16, 2008) (``USAA...

  11. Nanophotonic interactions between organic excitons and plasmonic metasurfaces (Conference Presentation)

    Science.gov (United States)

    O'Carroll, Deirdre M.

    2016-09-01

    Thin-film organic semiconductor materials are emerging as energy-efficient, versatile alternatives to inorganic semiconductors for display and solid-state lighting applications. Additionally, thin-film organic laser and photovoltaic technologies, while not yet competitive with inorganic semiconductor-based analogues, can exhibit small device embodied energies (due to comparatively low temperature and low energy-use fabrication processes) which is of interest for reducing overall device cost. To improve energy conversion efficiency in thin-film organic optoelectronics, light management using nanophotonic structures is necessary. Here, our recent work on improving light trapping and light extraction in organic semiconductor thin films using nanostructured silver plasmonic metasurfaces will be presented [1,2]. Numerous optical phenomena, such as absorption induced scattering, out-of-plane waveguiding and morphology-dependent surface plasmon outcoupling, are identified due to exciton-plasmon coupling between the organic semiconductor and the metasurface. Interactions between localized and propagating surface plasmon polaritons and the excitonic transitions of a variety of organic conjugated polymer materials will be discussed and ways in which these interactions may be optimized for particular optoelectronic applications will be presented. [1] C. E. Petoukhoff, D. M. O'Carroll, Absorption-Induced Scattering and Surface Plasmon Out-Coupling from Absorber-Coated Plasmonic Metasurfaces. Nat. Commun. 6, 7899-1-13 (2015). [2] Z. Shen, D. M. O'Carroll, Nanoporous Silver Thin Films: Multifunctional Platforms for Influencing Chain Morphology and Optical Properties of Conjugated Polymers. Adv. Funct. Mater. 25, 3302-3313 (2015).

  12. Interface Energy Alignment of Atomic-Layer-Deposited VOx on Pentacene: an in Situ Photoelectron Spectroscopy Investigation.

    Science.gov (United States)

    Zhao, Ran; Gao, Yuanhong; Guo, Zheng; Su, Yantao; Wang, Xinwei

    2017-01-18

    Ultrathin atomic-layer-deposited (ALD) vanadium oxide (VOx) interlayer has recently been demonstrated for remarkably reducing the contact resistance in organic electronic devices (Adv. Funct. Mater. 2016, 26, 4456). Herein, we present an in situ photoelectron spectroscopy investigation (including X-ray and ultraviolet photoelectron spectroscopies) of ALD VOx grown on pentacene to understand the role of the ALD VOx interlayer for the improved contact resistance. The in situ photoelectron spectroscopy characterizations allow us to monitor the ALD growth process of VOx and trace the evolutions of the work function, pentacene HOMO level, and VOx defect states during the growth. The initial VOx growth is found to be partially delayed on pentacene in the first ∼20 ALD cycles. The underneath pentacene layer is largely intact after ALD. The ALD VOx is found to contain a high density of defect states starting from 0.67 eV below the Fermi level, and the energy level of these defect states is in excellent alignment with the HOMO level of pentacene, which therefore allows these VOx defect states to provide an efficient hole-injection pathway at the contact interface.

  13. High capacitance organic field-effect transistors with modified gate insulator surface

    Science.gov (United States)

    Majewski, L. A.; Schroeder, R.; Grell, M.; Glarvey, P. A.; Turner, M. L.

    2004-11-01

    In this paper, we report on flexible, high capacitance, pentacene, and regioregular poly(3-hexylthiophene) (rr-P3HT) organic field-effect transistors fabricated on metallized Mylar films. The gate insulator, Al2O3, was prepared by means of anodization. We show that covering the anodized gate insulator with an octadecyltrichlorosilane self-assembled monolayer or apoly(α-methylstyrene) capping layer has the same effect on carrier mobility as for thermally grown silicon oxide. In addition, temperature-dependent measurements of mobility were performed on transistors fabricated with and without modification of the gate dielectric. In the case of both the pentacene and the rr-P3HT transistors, the μ(T ) behavior shows that the cause of the mobility enhancement through surface modification is not a reduction in the level of energetic disorder (σ in Bässler's model), as in the case of the fully amorphous organic semiconductor poly(triarylamine) [Veres et al., Adv. Funct. Mater. 13, 199 (2003)]. It appears that the surface modification improves mobility by changing the morphology of the semiconducting films.

  14. Molecular dynamics simulations of peptides at the air-water interface: influencing factors on peptide-templated mineralization.

    Science.gov (United States)

    Jain, Alok; Jochum, Mara; Peter, Christine

    2014-12-30

    Biomineralization is the intricate, biomedically highly relevant process by which living organisms deposit minerals on biological matrices to stiffen tissues and build skeletal structures and shells. Rapaport and coworkers ( J. Am. Chem. Soc. 2000 , 122 , 12523 ; Adv. Funct. Mater. 2008 , 18 , 2889 ; Acta Biomater. 2012 , 8 , 2466 ) have designed a class of self-assembling amphiphilic peptides that are capable of forming hydrogels and attracting ions from the environment, generating structures akin to the extracellular matrix and promoting bone regeneration. The air-water interface serves both in experiment and in simulations as a model hydrophobic surface to mimic the cell's organic-aqueous interface and to investigate the organization of the peptide matrix into ordered β-pleated monolayers and the subsequent onset of biomineral formation. To obtain insight into the underlying molecular mechanism, we have used molecular dynamics simulations to study the effect of peptide sequence on aggregate stability and ion-peptide interactions. We find-in excellent agreement with experimental observations-that the nature of the peptide termini (proline vs phenylalanine) affect the aggregate order, while the nature of the acidic side chains (aspartic vs glutamic acid) affect the aggregate's stability in the presence of ions. These simulations provide valuable microscopic insight into the way ions and peptide templates mutually affect each other during the early stages of biomineralization preceding nucleation.

  15. Graphene Nano-Electrodes for DNA Sequencing: an Ab initio Perspective

    Science.gov (United States)

    Scheicher, R. H.; Prasongkit, J.; Grigoriev, A.; He, Y.; Liu, M.; Ahuja, R.

    2012-02-01

    The proposal was made that a graphene nanogap could be used to probe the transverse conductance of individual nucleotides in DNA to rapidly identify the associated base sequence. Experimentally, the characteristic drop in ionic current associated with translocation events of DNA passing through a graphene nanopore was measured. Using first-principles methods, we evaluated the performance of two graphene nano-electrodes configurations for nucleobase identification. In the first study, Nano Lett. 11, 1941 (2011), we investigated the electronic transport properties of the four nucleotides when located in a graphene nanogap by employing density functional theory and the non-equilibrium Green's function method. In particular, we determined the electrical current variation at finite bias due to changes in the nucleotides orientation. Our second study, Adv. Funct. Mater. 21, 2674 (2011), utilized molecular dynamics simulations in conjunction with electronic transport calculations to explore specifically the effect of the hydrogenated graphene edges on the translocating DNA. It is found that edge-hydrogenated graphene electrodes facilitate the temporary formation of weak H-bonds with suitable atomic sites in the nucleotides.

  16. The Cause of the Second Labor Cesarean Delivery and Its Influence on Mater and Infant%第二产程剖宫产的原因以及对母婴的影响研究

    Institute of Scientific and Technical Information of China (English)

    沈霞

    2014-01-01

    Objective:To investigate the causes of the second labor cesarean section and its impact on mater and infant,reduce the rate of complications on mater and infant.Method:Two hundred and four cases of parturients give parallel cesarean delivery operation in our hospital from August 2011 to November 2013 were selected as research objects. They were divided into the the first stage and the second stage of labor group. Puerpera clinical data were retrospectively analyzed,surgical indications,complications rate,mater and child condition were compared between the two groups.Result:19 cases of macrosomias and 28 cases of amniotic fluid polluters were seen in the first stage of labor group,while in the second stage of labor group were 31 cases and 44 cases separately.The differences between the two group were significant(P<0.05).The incidence of malpositions in the first stage of labor group was significantly lower than the second stage of labor group(P<0.05).The incidences of complications during(1.8%) and after(1.8%) the operation were also significantly lower than that of the second stage of labor group 19.6%,10.9%for during and after the operation separately(P<0.05).Conclusion:The second line labor cesarean section can damage the mater and newborn in some degree. The incidence of postoperative complications can be increased in this situation. So the parturients should try to avoid the second line labor cesarean section,if not,the experienced doctors are needed for the operation. Avoiding the complications the preoperative sufficient preparation is also needed.%目的:探讨第二产程剖宫产的原因及其对母婴的影响,降低母婴并发症发生率。方法:选取2011年8月-2013年11月于笔者所在医院待产并行剖宫产手术产妇204例为研究对象,将其分为第一产程组与第二产程组两组,对比两组手术指征、并发症发生率、母婴情况等。结果:第一产程组出现巨大儿19例、羊水污染28例,明显

  17. The present situation and countermeasure analysis on higher vocational graduates towards alma mater satisfaction--Case study of a higher vocational demonstration colleges in Guangdong Province%高职毕业生对母校满意度现状及对策分析--以广东省某高职示范院校为例

    Institute of Scientific and Technical Information of China (English)

    赵晋芳

    2015-01-01

    Based on the analysis of higher vocational graduates towards alma mater satisfaction, it can analyse influence factors and put forward some countermeasures to improve the higher vocational graduates towards alma mater satisfaction. So it can provide reference for improving the quality of higher vocational education and sustainable development in higher vocational colleges.%在分析高职毕业生对母校满意度现状的基础上,分析影响因素并提出提升高职学生对学校的满意度对策,为提高高职院校人才培养质量以及高职院校可持续发展提供借鉴。

  18. Collagen-inspired self-assembling materals

    NARCIS (Netherlands)

    Skrzeszewska, P.J.

    2011-01-01

      The rapid increase of the quality of life together with the progress of medical science asks for the development of new, tuneable and controllable materials. For the same reason, materials used for biomedical applications have to be increasingly biocompatible, biodegradable and biofunctional

  19. Alma mater ootab tagasi / Triin Tabur

    Index Scriptorium Estoniae

    Tabur, Triin

    2011-01-01

    Tartu Ülikooli arstiteaduskonna ja sotsiaalministeeriumi koostööna käivitunud täiendusõppeprogrammist, mille eesmärgiks on arstiteaduse põhiõppe lõpetanud, ent kliinilisest tööst eemaldunud arstid raviasutustesse tagasi tuua

  20. "… It's Really Ultimately Very Cruel …": contrasting English intensifier collocations across EFL writing and academic spoken discourse "It's Really Ultimately Very Cruel": contrastando colocações de advérbios de intensidade em inglês entre a escrita de aprendizes de EFL e o discurso acadêmico oral de falantes nativos

    Directory of Open Access Journals (Sweden)

    Leonardo Juliano Recski

    2004-12-01

    Full Text Available This paper investigates and contrasts recurrent intensifier collocations across a corpus of EFL writing - The International Corpus of Learner English - ICLE (Granger, 1993 and The Michigan Corpus of Academic Spoken English - MICASE (Simpson et al., 2002. It seeks to show that such recurrent collocations are an important part of writers and speakers' linguistic repertoire and that they may provide a window onto their lexicon. On general grounds, the results indicate that there is a great predominance of boosters over maximizers and that a limited number of maximizers and boosters are used in recurrent combinations. The analysis further revealed that maximizers tend to intensify non-gradable words while boosters tend to intensify gradable ones and that EFL writers' overuse of intensifiers appears to be associated with colloquial style and an exaggerated tone that is often considered to be inappropriate in formal academic texts.Este artigo investiga e contrasta colocações recorrentes de advérbios de intensidade entre um corpus composto por textos produzidos em inglês como L2 - o Corpus Internacional de Inglês de Aprendizes - ICLE (Granger, 1993 e o corpus de transcrições de fala de inglês acadêmico da Universidade de Michigan - MICASE (Simpson et al., 2002. O artigo busca demonstrar que a recorrência de tais colocações constitui uma parte importante do repertório lingüístico de falantes e escritores e que, assim, pode fornecer uma amostra do léxico dessas populações. De forma geral, os resultados indicam que há uma grande predominância de amplificadores sobre maximizadores e que um número reduzido de maximizadores e amplificadores são utilizados em combinações recorrentes. Além disso, a análise revelou que maximizadores tendem a intensificar palavras não escalares enquanto amplificadores tendem a intensificar palavras escalares e que o uso excessivo de advérbios de intensidade por parte dos aprendizes de L2 parece estar

  1. Flexible nanocrystal-coated glass fibers for high-performance thermoelectric energy harvesting.

    Science.gov (United States)

    Liang, Daxin; Yang, Haoran; Finefrock, Scott W; Wu, Yue

    2012-04-11

    Recent efforts on the development of nanostructured thermoelectric materials from nanowires (Boukai, A. I.; et al. Nature 2008, 451, (7175), 168-171; Hochbaum, A. I.; et al. Nature 2008, 451, (7175), 163-167) and nanocrystals (Kim, W.; et al. Phys. Rev. Lett. 2006, 96, (4), 045901; Poudel, B.; et al. Science 2008, 320, (5876), 634-638; Scheele, M.; et al. Adv. Funct. Mater. 2009, 19, (21), 3476-3483; Wang, R. Y.; et al. Nano Lett. 2008, 8, (8), 2283-2288) show the comparable or superior performance to the bulk crystals possessing the same chemical compositions because of the dramatically reduced thermal conductivity due to phonon scattering at nanoscale surface and interface. Up to date, the majority of the thermoelectric devices made from these inorganic nanostructures are fabricated into rigid configuration. The explorations of truly flexible composite-based flexible thermoelectric devices (See, K. C.; et al. Nano Lett. 2010, 10, (11), 4664-4667) have thus far achieved much less progress, which in principle could significantly benefit the conversion of waste heat into electricity or the solid-state cooling by applying the devices to any kind of objects with any kind of shapes. Here we report an example using a scalable solution-phase deposition method to coat thermoelectric nanocrystals onto the surface of flexible glass fibers. Our investigation of the thermoelectric properties yields high performance comparable to the state of the art from the bulk crystals and proof-of-concept demonstration also suggests the potential of wrapping the thermoelectric fibers on the industrial pipes to improve the energy efficiency.

  2. Kinetic Monte Carlo simulation of the efficiency roll-off, emission color, and degradation of organic light-emitting diodes (Presentation Recording)

    Science.gov (United States)

    Coehoorn, Reinder; van Eersel, Harm; Bobbert, Peter A.; Janssen, Rene A. J.

    2015-10-01

    The performance of Organic Light Emitting Diodes (OLEDs) is determined by a complex interplay of the charge transport and excitonic processes in the active layer stack. We have developed a three-dimensional kinetic Monte Carlo (kMC) OLED simulation method which includes all these processes in an integral manner. The method employs a physically transparent mechanistic approach, and is based on measurable parameters. All processes can be followed with molecular-scale spatial resolution and with sub-nanosecond time resolution, for any layer structure and any mixture of materials. In the talk, applications to the efficiency roll-off, emission color and lifetime of white and monochrome phosphorescent OLEDs [1,2] are demonstrated, and a comparison with experimental results is given. The simulations show to which extent the triplet-polaron quenching (TPQ) and triplet-triplet-annihilation (TTA) contribute to the roll-off, and how the microscopic parameters describing these processes can be deduced properly from dedicated experiments. Degradation is treated as a result of the (accelerated) conversion of emitter molecules to non-emissive sites upon a triplet-polaron quenching (TPQ) process. The degradation rate, and hence the device lifetime, is shown to depend on the emitter concentration and on the precise type of TPQ process. Results for both single-doped and co-doped OLEDs are presented, revealing that the kMC simulations enable efficient simulation-assisted layer stack development. [1] H. van Eersel et al., Appl. Phys. Lett. 105, 143303 (2014). [2] R. Coehoorn et al., Adv. Funct. Mater. (2015), publ. online (DOI: 10.1002/adfm.201402532)

  3. Photo-induced charge separation across the graphene-TiO2 interface is faster than energy losses: a time-domain ab initio analysis.

    Science.gov (United States)

    Long, Run; English, Niall J; Prezhdo, Oleg V

    2012-08-29

    Graphene-TiO(2) composites exhibit excellent potential for photovoltaic applications, provided that efficient photoinduced charge separation can be achieved at the interface. Once charges are separated, TiO(2) acts as an electron carrier, while graphene is an excellent hole conductor. However, charge separation competes with energy losses that can result in rapid electron-hole annihilation inside metallic graphene. Bearing this in mind, we investigate the mechanisms and, crucially, time scales of electron transfer and energy relaxation processes. Using nonadiabatic molecular dynamics formulated within the framework of time-domain density functional theory, we establish that the photoinduced electron transfer occurs several times faster than the electron-phonon energy relaxation (i.e., charge separation is efficient in the presence of electron-phonon relaxation), thereby showing that graphene-TiO(2) interfaces can form the basis for photovoltaic and photocatalytic devices using visible light. We identify the mechanisms for charge separation and energy losses, both of which proceed by rapid, phonon-induced nonadiabatic transitions within the manifold of the electronic states. Electron injection is ultrafast, owing to strong electronic coupling between graphene and TiO(2). Injection is promoted by both out-of-plane graphene motions, which modulate the graphene-TiO(2) distance and interaction, and high-frequency bond stretching and bending vibrations, which generate large nonadiabatic coupling. Both electron injection and energy transfer, injection in particular, accelerate for photoexcited states that are delocalized between the two subsystems. The theoretical results show excellent agreement with the available experimental data [Adv. Funct. Mater. 2009, 19, 3638]. The state-of-the-art simulation generates a detailed time-domain atomistic description of the interfacial charge separation and relaxation processes that are fundamental to a wide variety of applications

  4. Recent Insights Into the Prenucleation Cluster Pathway

    Science.gov (United States)

    Gebauer, D.; Kellermeier, M.; Berg, J. K.

    2012-12-01

    Stable calcium carbonate pre-nucleation clusters (PNCs) form in aqueous solution prior to nucleation of CaCO3 (1). Computer simulations suggest that the thermodynamic stability of PNCs is based upon strong hydration in combination with a distinct entropic contribution (2). In this way, PNCs can compete enthalpically with ion pairs and entropically with amorpous calcium carbonate (ACC). The clue is a high degree of structural disorder in highly dynamic, liquid- and chain-like polymeric structures of calcium carbonate ion pairs (2). Nucleation of solid calcium carbonate from these polymeric species proceeds via PNC aggregation rather than via ion-by-ion additions to un-/metastable nuclei (3). Owing to these basic characteristics, the pre-nucleation cluster pathway has been referred to as "non-classical nucleation" (4). Non-classical nucleation leads to distinct short-range structural features in ACC, and depending on pH they relate to the crystalline long-range order of calcite or vaterite (5). This suggests that calcium carbonate exhibits polyamorphism, and that distinct polyamorphs may play a central role during polymorph selection. In this contribution, we outline the scenario described above, and focus on recent insights into the pre-nucleation cluster pathway. 1. D. Gebauer, A. Völkel & H. Cölfen, Science 322, 1819-1822 (2008). 2. R. Demichelis, P. Raiteri, J.D. Gale, D. Quigley, D. Gebauer, Nat. Commun. 2, 590 (2011). 3. M. Kellermeier et al., Adv. Funct. Mater., DOI: 10.1002/adfm.201200953 (2012). 4. D. Gebauer, H. Cölfen, Nano Today 6, 564-584 (2011). 5. D. Gebauer et al., Angew. Chem. Int. Ed. 49, 8889-8891 (2010).

  5. La categorización adverbonominal. Las estructuras ADV(Nment vôtre / ADV(Nly yours

    Directory of Open Access Journals (Sweden)

    Luisa Mora Millán

    2011-01-01

    Full Text Available The adverb is a prolific category, especially with regard to neologisms. In this paper we analyze some noun-based adverbial neologisms, found in the lexicon of the internet, with the shared characteristic that they cannot be paraphrased by structures of the type in a/a Adj manner or any other structure usually associated with adverbs ending in -ment (-ly. We propose the term adverb-nominal to refer to the twofold mode of signification of these neologisms.

  6. 偏头痛大鼠硬脑膜肥大细胞脱颗粒与神经源性炎症相关因子的变化%Changes on degranulation of mast cells and neurogenic inflammation-related factors in the dura mater of the rat model of migraine

    Institute of Scientific and Technical Information of China (English)

    徐武; 史兆春; 韦俊超; 曹月州; 吴婷; 万琪

    2011-01-01

    目的 观察偏头痛大鼠硬脑膜肥大细胞脱颗粒与神经源性炎症相关因子的变化,探讨偏头痛疼痛产生的可能机制.方法 64只SD大鼠随机分为刺激组(32只)和假手术组(32只).电刺激大鼠单侧三叉神经节建立偏头痛模型,放射免疫法测定刺激侧颈静脉血中降钙素基因相关肽(CGRP)的含量.酶联免疫吸附法测定刺激侧颈静脉血中组胺和硬脑膜中前列腺素E2(PGE2)的含量,甲苯胺蓝染色观察硬脑膜肥大细胞的数量及脱颗粒百分率,免疫组织化学染色法、免疫蛋白质印迹技术观察硬脑膜中环氧化酶-2(COX-2)的阳性细胞数及蛋白表达.结果 假手术组和刺激组颈静脉血中CGRP含量分别为(59.20±11.66)pg/ml和(82.84±16.24)pg/ml(t=-3.34);组胺含量分别为(9.87±0.88)ng/ml和(11.59±1.20)ng/ml(t=-3.27);硬脑膜中肥大细胞数量分别为15.46±2.40和11.63±1.67(t=3.71),脱颗粒百分率分别为14.09%±4.53%、29.10%±9.39%(t=-4.07).两组硬脑膜中PGE2的含量分别为(80.70±10.60)pg/ml和(382.30±20.90)pg/ml(t=-16.674);硬脑膜中COX-2阳性细胞数分别为42.00±18.40和139.00±20.50(t=-7.994),COX-2蛋白表达(吸光度值)分别为19.50±9.20和359.20±21.90(t=-5.190).两组间比较,上述指标差异均有统计学意义(P<0.05).结论 电刺激单侧三叉神经节可诱导硬脑膜肥大细胞脱颗粒及神经源性炎症的产生,相关炎症因子的改变可能是偏头痛疼痛发生的重要病理生理基础.%Objective To observe the changes on the neurogenic inflammation-related factors in the dura mater of the rat model of migraine and investigate the possible mechanism of the pain of migraine.Methods SD rats were randomly divided into stimulation group ( n = 32 ) and sham group ( n = 32 ).Unilateral trigeminal ganglion was stimulated to induce migraine for rats in the stimulation group. Rats in the sham group were subjected to sham surgery. The levels of calcitonin gene-related peptide (CGRP) in

  7. Development of raw materical iron-removal process and automatic additive adding system for high quality silica bricks production%优质硅砖生产中原料除铁工艺及添加剂自动添加系统的研发

    Institute of Scientific and Technical Information of China (English)

    白城; 吴占德; 柏杉

    2014-01-01

    To increase yield and performance indicators and decrease product energy consumption, the key parts and equipment in production of silica bricks which can easily effect product perform-ances and yield were studied. Furthermore,with reference to domestic and international advanced technologies,the raw materical iron-removal process and automatic added system for additives and mineralizers were developed and a best technical program was determined for the production of high quality silica bricks to optimize product quality and minimize the energy consumption.%为提高硅砖的成品率和性能指标,进一步降低产品能耗,研究了硅砖生产过程中容易影响制品性能和成品率的关键环节和设备,并参考国内外先进技术,研发出原料除铁工艺及添加剂、矿化剂自动添加系统,确定了优质硅砖生产线相应环节的最佳技术方案,最大限度地提高了成品质量并降低能耗。

  8. Effect of Kınesıotapıng and Knee Brace on Functıonal Performance in Recreatıonal Athletes

    Science.gov (United States)

    Ulusoy, Burak; İldiz, Bülent; Tunay, Volga Bayrakçı

    2014-01-01

    Objectives: Kinesiotaping is a popular taping method that is used for both therapeutic and performance enchancement purposes. Knee braces are widely used for prevention in sport injuries but their performance effectiveness is still controversial. The aim of this study was to determine whether kinesiotape or brace was more effective on functional performance. Methods: A total twenty male recreational football players (Mean±Standart Deviation (SD) age: 22.5±0.68 years, height: 175.15±3.37 cm, body weight: 74.52±12.41 kg), voluntarily participated in this study. Participants were tested with kinesiotape, with brace and without kinesiotape and brace. Tests were applied one day after patellar kinesiotaping (correction technique). Balance property measured with Modified Y balance Test (dynamic test), agility measured by T test, muscle strength and anaerobic power assessed by vertical jump and triple hop tests. Wilcoxon signed rank test was employed for determining the statistical significance of tests with kinesiotape, with brace and without kinesiotape and brace. Results: In analysis; There were statistically significant differences found in Triple hop test with kinesiotaping and without kinesiotaping and brace, in T test with bracing and kinesiotaping, in vertical jump with kinesiotaping and without kinesiotaping and brace (pkinesiotaping in all tests) No statistically significant difference was found in modified Y balance test all groups (p> 0.05). Conclusion: Consequently, kinesiotaping had positive effects on agility and muscle strength but had no effects on balance in football players. On the other hand, brace had no effects on functional performance tests.

  9. Effect of Kınesıotapıng and Knee Brace on Functıonal Performance in Recreatıonal Athletes

    OpenAIRE

    Ulusoy, Burak; İldiz, Bülent; Tunay, Volga Bayrakçı

    2014-01-01

    Objectives: Kinesiotaping is a popular taping method that is used for both therapeutic and performance enchancement purposes. Knee braces are widely used for prevention in sport injuries but their performance effectiveness is still controversial. The aim of this study was to determine whether kinesiotape or brace was more effective on functional performance. Methods: A total twenty male recreational football players (Mean±Standart Deviation (SD) age: 22.5±0.68 years, height: 175.15±3.37 cm, b...

  10. 小儿外科手术中行丙泊酚靶控加单次硬膜的效果探究%Effect exploration of implementation of propofol target control plus one-time dura mater in pediatric surgery

    Institute of Scientific and Technical Information of China (English)

    时文俊

    2014-01-01

    Objective To investigate the implementation effect of propofol target control plus one-time dura mater in pediatric surgery. Methods Eighty children who received surgical treatment in our hospital from September 2012 to January 2014 were selected as the study subjects and randomly and evenly divided into the study group and the control group, which received one-time epidural plus propofol target control and ketamine anesthesia respectively. The patients' blood pressure, heart rate, oxyhemoglobin saturation, physical tamper, muscle relaxation and other indicators of the two groups in different time periods were compared. Results In the control group, the blood pressure and heart rates at the beginning of surgery and at the end of surgery increased significantly compared to the blood pressure and heart rate before surgery(P < 0.05), and in the study group, the blood pressure did not change significantly, but it was lower than that of the control group in the corresponding period, with statistically significant difference(P<0.05). In the study group, the heart rates at the beginning of surgery and at the end of surgery reduced significantly compared to the heart rate before surgery(P<0.05) and reduced a lot compared to the heart rate of the control group in the corresponding period(P<0.05). The study group had less physical tamper and shorter awakening time, with statistically significant differences(P < 0.05). Conclusion In pediatric surgery, the implementation of propofol target control plus one-time dura mater does not have large influence on the children's respiratory circulation and has the features of good effect, fast awakening and safety.%目的:探究在小儿外科手术中行丙泊酚靶控加单次硬膜的效果。方法选取2012年9月~2014年1月来本院接受手术治疗的80例患儿作为研究对象,随机等分为研究组和对照组,分别为单次硬膜外加丙泊酚靶控和氯胺酮麻醉,比较不同时间段的两组患者血

  11. Effects of Yunnan Baiyao through inner layer of cerebral dura mater on cerebral perfusion and oxygen metabolism in rabbits with severe traumatic brain injury%硬脑膜夹层导入云南白药对兔重型颅脑创伤后脑灌注和氧代谢的影响

    Institute of Scientific and Technical Information of China (English)

    徐震; 吕晓皑; 尹利明; 竺国充; 张昕; 李徐; 陈祖鹏

    2012-01-01

    Objective: To explore the effects of Yunnan Baiyao through inner layer of cerebral dura mater on cerebral perfusion and oxygen metabolism in rabbits with severe traumatic brain injury. Methods: 40 New Zealand white rabbits were divided into cerebral dura mater Yunnan Baiyao group(A group), intravenous Mannitol group(B group), oral Yunnan Baiyao group (C group) and control group(D group). Record ICP, CPP and MABP. TCD measured cerebral blood flow volume. Monitor blood gas analysis in femora) artery and internal jugular venous bulb, accounting the CEO2 and D-values of glucose and lactic acid between artery and venous bulb. Results: From 12 to 36 hour after therapy: the ICP of A was highter than B, the CPP and CBFV were lower than B (P<0.05). At 48 hour: the ICP of A was highter than B and lower than C and D, the CPP was lower than B and highter than Cand D, while the CBFV of A was highter than C and D(P<0.05). From 60 to 96 hour: the ICP of A was lower than C and D, the CPP of A was highter than C and D, the CBFV of A was highter than B, C and D(P<0.05). From 36 to 96: The Glua-jv and CEO2 of A were highter than B, C and D, while the Lacjv-a was lower than B, C and D(P<0.05). Conclusion: Yunnan Baiyao through cerebral dura mater can reach effective treatment concentration in brain. By increasing the efficiency of oxygen metabolism of brain it can ameliorate brain cell hypoxia and energy metabolism handicap, adjust cerebral microcirculation, thus improves cytotoxic brain edema, decreases cerebral blood flow resistance, reduces ICP and increase the CPP and CBFV.%目的:探讨硬脑膜夹层应用云南白药对兔重型颅脑创伤后颅内压、脑血流量和脑代谢的影响.方法:将40只雄性新西兰大白兔分为硬脑膜夹层云南白药组(A组)、静脉甘露醇组(B组)、口服云南白药组(C组)和空白组(D组),制作重型颅脑创伤模型,行颅内压(ICP)监测,记录平均动脉压(MABP),计算脑灌注压(CPP),经颅多普勒(TCD)测定脑

  12. Synthesis of Freestanding HfO2 Nanostructures

    Science.gov (United States)

    2011-04-05

    Tang J, Fabbri J, Robinson RD, Zhu Y, Herman IP, Steigerwald ML, Brus LE: Solid-solution nanoparticles:use of a nonhydrolytic sol-gel synthesis to...colloidal HfO2 nanorods. Adv Mater 2007, 19:2608-2612. Page 21 5. Qiu X, Howe JY, Cardoso MB, Polat O, Heller W: Size control of highly ordered HfO2

  13. A Partnership Training Program: Studying Targeted Drug Delivery Using Nanoparticles In Breast Cancer Diagnosis and Therapy

    Science.gov (United States)

    2015-12-01

    treatment of cancer. Chemical Society Reviews 42(19): 7816-7833, 2013. 3. Gulaka PK, Yu JX, Liu L, Mason RP, Kodibagkar VD. Novel S-Gal analogs as 1H...L. Sheihet, I. P. Fuentes, S. Chen, C. M. Roth , P. V. Moghe, Adv. Healthcare Mater. 2013, 2, 1236. [15]C. Xu, Y. Niu, A. Popat, S. Jambhrunkar, S

  14. High-Performance Ttransparent and Stretchable All-Solid Supercapacitors Based on Highly Aligned Carbon Nanotube Sheets

    Science.gov (United States)

    2014-01-09

    bending, respectively. 1. Huang, J. S., Li, G. & Yang, Y. A semi-transparent plastic solar cell fabricated by a lamination process. Adv. Mater. 20, 415...yarn supercapacitors for textiles and microdevices. Nat. Commun. 4, 1971–1978 (2013). 31. Stoller, M. D. & Ruoff, R. S. Best practice methods for

  15. Mean-Field Models of Structure and Dispersion of Polymer-nanoparticle Mixtures

    Science.gov (United States)

    2010-07-29

    creative idea of modeling the grafted nanoparticle as a star polymer with a finite sized (soft) core to shed light on the self- assembly behavior one might...8, 29 [Links]. 3 E. P. Giannelis, R. Krishnamoorti and E. Manias , Adv. Polym. Sci., 1999, 138, 107–147 [Links]. 4 M. Alexandre and P. Dubois, Mater

  16. Highly Efficient Organic Photovoltaic Cells from Polymer-Aligned Carbon Nanotube Dispersed Heterojunctions

    Science.gov (United States)

    2009-09-01

    pyrolysis of iron(II) phthalocyanine (FePc, a metal heterocycle molecules containing nitrogen), in either the presence or absence of additional...create wall/rock climbing robots, super-grip tires , and rapid repairs for various systems. In one of our relevant studies (Adv. Mater. 2007, 19, 3844

  17. Light Emitting Transistors of Organic Single Crystals

    Science.gov (United States)

    Iwasa, Yoshihiro

    2009-03-01

    emitting molecular solids, providing novel opportunities to get further insight on the intrinsic optoelectronic processes in organic semiconductors. [4pt] [1] T. Takahashi et al., Adv. Funct. Mater. 17, 1623 (2007).[0pt] [2] T. Takenobu et al., Phy. Rev. Lett. 100, 066601 (2008).

  18. Characterization of multifunctional structural capacitors for embedded energy storage

    Science.gov (United States)

    Lin, Yirong; Sodano, Henry A.

    2009-12-01

    Multifunctional composites are a class of materials that combine structural and other functionalities such as sensing, actuation, energy harvesting, and vibration control in order to maximize structural performance while minimizing weight and complexity. Among all the multifunctional composites developed so far, piezoelectric composites have been widely studied due to the high coupling of energy between the electrical and mechanical domains and the inherently high dielectric constant. Several piezoelectric fiber composites have been developed for sensing and actuation applications; however, none of the previously studied composites fully embed all components of an energy storage device as load bearing members of the structure. A multifunctional fiber that can be embedded in a composite material to perform sensing and actuation has been recently developed [Y. Lin and H. A. Sodano, Adv. Funct. Mater. 18, 592 (2008)], in addition to providing load bearing functionality. The design was achieved by coating a common structural fiber, silicon carbide, with a barium titanate piezoelectric shell, and poling the active material radically by employing the structural fiber as one of the electrodes. The silicon carbide core fiber also carries external mechanical loading to protect the brittle barium titanate shell from fracture. The excellent piezoelectric and dielectric properties of the barium titanate material make the active structural fiber an outstanding candidate for converting and storing ambient mechanical energy into electrical energy to power other electric devices in the system. This paper focuses on the characterization of energy storage capability of the multifunctional fiber provided by the dielectric properties of the barium titanate shell. The capacitances of the multifunctional fibers with four different aspect ratios are tested and compared with the theoretical expressions for the cylindrical capacitor, while the breakdown voltages of the multifunctional

  19. KamLAND-PICO Dark Mater Search Project

    Science.gov (United States)

    Fushimi, K.; Awatani, Y.; Ejiri, H.; Hazama, R.; Ikeda, H.; Imagawa, K.; Inoue, K.; Kozlov, A.; Orito, R.; Shima, T.; Sugawara, R.; Yasuda, K.

    Dark matter search project KamLAND-PICO is proposed. The first phase of the project aims to verifying the annual modulation signal which has been reported by DAMA/LIBRA. The last phase of the project aims to determining the type of interaction between WIMPs and nucleus. The thin and wide area NaI(Tl) detector PICO-LON has been developed to determine the type of WIMPs interaction. The good performance of PICO-LON detector was obtained. The energy threshold was as low as 2 keVee and the the energy resolution was as small as 25% at 60 keVee. The highly pure NaI(Tl) crystal has been developed in collaboration with the Japanese developer. The purity of U and Th chain contaminants have been reduced to the order of a few tens of ppt. It should be remarked that the concentration of 210Pb was reduced to about 60 μBq/kg. The sensitivity to spin-independent WIMPs are discussed by applying 170 modules of NaI(Tl) with the dimension of 5 inch ϕ× 5 inch.

  20. The Marriage of Alma Mater to Adam Smith.

    Science.gov (United States)

    Buescher, John B.

    1987-01-01

    Businesses and universities must be encouraged to act from their traditional positions of strength, based on the longest view and the broadest interests. They must examine carefully their potential sources of conflict as well as opportunities for benefit before engaging in alliances that may become complex and difficult to manage. (MSE)

  1. Alma mater NYC : võimenda, kiirenda, kuhja / Mariliis Lilover

    Index Scriptorium Estoniae

    Lilover, Mariliis

    2014-01-01

    Mariliis Liloveri arhitektuurialastest õpingutest New Yorgis (Graduate School of Architecture, Planning and Preservation at Columbia University) ja tema arvamusest, et koolide ülesandeks on koolitada selline arhitekt, kelle eesmärk peaks olema ületada nii iseennast kui ka tellija unistusi, kavandades midagi, mida klient algul ei osanud soovida, kuid usub lõpuks, et just sellisest tulemusest ta unistaski

  2. Why is the universe more partial to mater than antimatter?

    CERN Multimedia

    2006-01-01

    "B factory experiments at the Stanford Linear Accelerator (SLAC) in the USA and at the High Energy Accelerator Research Organization (KEK) in Japan have reached a new milestone in the quest to understand the matter-antimatter imbalance in our universe.

  3. Ilves nautis oma alma mater'i õhustikku / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2007-01-01

    President Toomas Hendrik Ilves ja Gruusia president Mihheil Saakashvili külastasid New Yorgis oma kunagist õpingutepaika Columbia ülikooli. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

  4. Saving Alma Mater: A Rescue Plan for America's Public Universities

    Science.gov (United States)

    Garland, James C.

    2009-01-01

    America's public universities educate 80% of our nation's college students. But in the wake of rising demands on state treasuries, changing demographics, growing income inequality, and legislative indifference, many of these institutions have fallen into decline. Tuition costs have skyrocketed, class sizes have gone up, the number of courses…

  5. Alma mater sõnas, pildis ja helis / Varje Sootak

    Index Scriptorium Estoniae

    Sootak, Varje, 1946-

    2007-01-01

    Tartu Ülikooli 375. aastapäeva puhul esitleti ülikooli kohvikus albumit "Universitas Tartuensis 375" ja samanimelise dokumentaalfilmi DVD-d. Viimase stsenaristideks on Jaak Lõhmus ja Lauri Vahtre, režissöörideks Rene Vilbre ja Märten Vaher

  6. Beatriz de Portugal y el Hospital Mater Dei de Tordesillas

    OpenAIRE

    Santo Tomás Pérez, Magdalena

    2004-01-01

    Producción Científica El presente trabajo fue presentado en el congreso Portugal e Castela na Idade Média celebrado en la universidade Portucalense Infante D. Henrique, de Porto, Portugal, en el año 2004 y está publicado en Castilla y el Mundo feudal. Homenaje al Profesor Julio Valdeón, obra dirigida por los profesores de la Uva Mª Isabel del Val Valdivieso y Pascual Martínez Sopena y editada por la Junta de Castilla y León y por la Universidad de Valladolid, en el volumen III, pp 4...

  7. Teacher History: Student Historians, Faculty Biographies, and the "Alma Mater"

    Science.gov (United States)

    Stofferahn, Steven A.

    2009-01-01

    When his department chair asked him a few years ago to take over as faculty advisor to their university's chapter of the Phi Alpha Theta history honor society, the author readily accepted. Not only would it provide a great opportunity to get to know some of their best students better, it would also help a junior faculty member like himself fulfill…

  8. Warm dense mater: another application for pulsed power hydrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Reinovsky, Robert Emil [Los Alamos National Laboratory

    2009-01-01

    Pulsed Power Hydrodynamics (PPH) is an application of low-impedance pulsed power, and high magnetic field technology to the study of advanced hydrodynamic problems, instabilities, turbulence, and material properties. PPH can potentially be applied to the study of the properties of warm dense matter (WDM) as well. Exploration of the properties of warm dense matter such as equation of state, viscosity, conductivity is an emerging area of study focused on the behavior of matter at density near solid density (from 10% of solid density to slightly above solid density) and modest temperatures ({approx}1-10 eV). Conditions characteristic of WDM are difficult to obtain, and even more difficult to diagnose. One approach to producing WDM uses laser or particle beam heating of very small quantities of matter on timescales short compared to the subsequent hydrodynamic expansion timescales (isochoric heating) and a vigorous community of researchers are applying these techniques. Pulsed power hydrodynamic techniques, such as large convergence liner compression of a large volume, modest density, low temperature plasma to densities approaching solid density or through multiple shock compression and heating of normal density material between a massive, high density, energetic liner and a high density central 'anvil' are possible ways to reach relevant conditions. Another avenue to WDM conditions is through the explosion and subsequent expansion of a conductor (wire) against a high pressure (density) gas background (isobaric expansion) techniques. However, both techniques demand substantial energy, proper power conditioning and delivery, and an understanding of the hydrodynamic and instability processes that limit each technique. In this paper we will examine the challenges to pulsed power technology and to pulsed power systems presented by the opportunity to explore this interesting region of parameter space.

  9. Cavernous hemangioma of the dura mater mimicking meningioma

    Directory of Open Access Journals (Sweden)

    Hambra Di Vitantonio

    2015-01-01

    Conclusions: Dural-based cavernous hemangiomas of the convexity are uncommon lesions. Up to now, only 13 cases have been described in the literature. The authors have discussed clinical aspects, radiological features, surgical treatment, and operative findings.

  10. Less is More: DoD’s Strategy for Facility Energy Security and Environmental Sustainability

    Science.gov (United States)

    2012-05-22

    funct.d testing a AbefdHn Proving &ound <VId S<VI Luis Obispo o Adv<VIced UXO dttKtion <VId ciscriminaion o llby ~ towed or front~nted 0 ~ l-uis...Weston Solutions GeoVision ITSI CH2M Hill UXB 3DGeophysics Zapata Inc. URS Corp Malcolm Pirnie Sky Research UXA Environ. Parsons Nova Research...progress • Many more planned • former Camp Sibert, AL • former Camp San Luis Obispo, CA • former Camp Butner, NC • Mare Island Naval Shipyard

  11. Laplace operators of infinite-dimensional Lie algebras and theta functions

    OpenAIRE

    Kac, Victor G.

    1984-01-01

    Until recently, the generalized Casimir operator constructed by Kac [Kac, V. G. (1974) Funct. Anal. Appl. 8, 68-70] has been the only known element of the center of a completion of the enveloping algebra of a Kac-Moody algebra. It has been conjectured [Deodhar, V. V., Gabber, O. & Kac, V. G. (1982) Adv. Math. 45, 92-116], however, that the image of the Harish-Chandra homomorphism contains all theta functions defined on the interior of the complexified Tits cone and hence separates the orbits ...

  12. Synthesis of Nanometer-sized Mesoporous Oxide Spheres

    Institute of Scientific and Technical Information of China (English)

    LUO; Qian

    2001-01-01

    [1]Kresge C.T., Leonowicz M. E., Roth W. J. et al. , Nature, 359, 710(1992)[2]Zhao D., Feng J., Huo Q. et al., Science. 297, 548(1998)[3]Zhao D., Huo Q., Feng J. et al. , J. Am. Chem. Soc. , 120, 6 024(1998)[4]Yang P., Zhao D., Margolese D. I. et al. , Nature, 396, 152(1998)[5]Attard G. S. , Barrlett P. N. , Coleman N. R. B. et al. , Science, 278, 838(1997)[6]Antonietti M.and Goltner C. , Angew. Chem. Int. Ed. Engl., 36, 910(1997)[7]Zhao D., Yang P., Melosh N. et al., Adv. Mater., 10, 1 380(1998)[8]Huo Q., Zhao D., Feng J. et al. , Adv. Mater., 9, 974(1997)[9].Yang H. , Coombs N. , Ozin G. A. , Nature, 386, 692(1997)[10]Lin H. P., Cheng S. , Mou C. Y. , Chem. Mater. , 10, 3 772(1998)[11]Grun M. , Klaus I. L. , Unger K. , Adv. Mater. , 9, 254(1997)[12]Huo Q. S. , Feng J. L. , Schuth F. et al. , Chem. Mater. , 9, 14(1997)[13]Qi L. M., Ma J. M., Cheng H. M. et al., Chem. Mater., 10, 1 623(1998)[14]Bagshaw S. A., Pinnavaia T. J., Angew. Chem. Int. Ed. Engl. , 35, 1 102(1996)[15]Stober W. , Fink A. , Bohn E. , J. Colloid . Interface. Sci. , 26, 62(1968)

  13. pi-Conjugated Gradient Copolymers Suppress Phase Separation and Improve Stability in Bulk Heterojunction Solar Cells

    Science.gov (United States)

    2014-01-01

    5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 5c. PROGRAM ELEMENT NUMBER 5b. GRANT NUMBER 5a. CONTRACT NUMBER Form Approved OMB NO...ray diffraction and differential scanning calorimetry , when the gradient copolymer was added (ESI†). The origin of the J–V curve distortion is...b) S. B. Darling and F. Q. You , RSC Adv., 2013, 3, 17633–17648. 2 For a comprehensive review, see: M. T. Dang, L. Hirsch and G. Wantz, Adv. Mater

  14. Light Trapping: Light Manipulation in Organic Photovoltaics (Adv. Sci. 7/2016)

    OpenAIRE

    Ou, Qing‐Dong; Li, Yan‐Qing; Tang, Jian‐Xin

    2016-01-01

    Light manipulation is becoming a general strategy for further enhancing the performance of organic photovoltaic cells. In article 1600123, various light trapping schemes are reviewed from the viewpoint of plasmonic and photonic resonances, addressing the external antireflection coatings, substrate geometry‐induced trapping, the role of electrode design in optical enhancement, as well as optically modifying charge extraction and photoactive layers by Jian‐Xin Tang and co‐workers.

  15. Plasmon resonant gold-coated liposomes for spectrally coded content release

    OpenAIRE

    Leung, Sarah J.; Troutman, Timothy S.; Romanowski, Marek

    2009-01-01

    We have recently introduced liposome-supported plasmon resonant gold nanoshells (Troutman et al., Adv. Mater. 2008, 20, 2604–2608). These plasmon resonant gold-coated liposomes are degradable into components of a size compatible with renal clearance, potentially enabling their use as multifunctional agents in applications in nanomedicine, including imaging, diagnostics, therapy, and drug delivery. The present research demonstrates that laser illumination at the wavelength matching the plasmon...

  16. Biocompatible Surface Chemistry Manipulation of Gold Nanorods Preserves Optical Properties for Bio-Imaging Applications

    Science.gov (United States)

    2015-12-18

    91 Park K (2006) Synthesis , characterization, and self-assembly of size tunable gold nanorods . Dissertation, Georgia Institute of Technology, Atlanta...Sun Y, Xia Y (2002) Shape-controlled synthesis of gold and silver nanoparticles. Science (New York, NY) 298:2176–2179. doi:10.1126/science.1077229...Vigderman L, Khanal BP, Zubarev ER (2012a) Functional gold nanorods : synthesis , self-assembly, and sensing applica- tions. Adv Mater (Deerfield Beach

  17. Materials Characterization and Microelectronic Implementation of Metal-insulator Transition Materials and Phase Change Materials

    Science.gov (United States)

    2015-03-26

    Transition MM Metamaterial MO Molecular Orbital MRAM Magnetic Random Access Memory MTFET Mott Transition Field-effect Transistor NA Numerical... Memory Devices Based on Free-standing VO2/TiO2 Microstructures Driven by Joule Heating," Adv. Mater., vol. 24, pp. 2929-2934, 2012. [57] R...Change Memory Devices," in IEEE, 2009. [98] M. Boniardi, A. Redaelli, A. Pirovano, I. Tortorelli, D. Ielmini and F. Pellizzer, "A physics- based

  18. Exploring the Potential of Nucleic Acid Bases in Organic Light Emitting Diodes

    Science.gov (United States)

    2014-01-01

    material properties, simplicity of use, and reduced cost indicate the promise of nucleobases for future OLED development . environmentally...plant sources, including salmon sperm, [ 19 ] calf thymus , [ 20 ] and vegetation [ 21 ] . After harvesting and purifi cation, DNA takes the form of a...the HBL (Type III) in order to develop ground- work for future devices. Adv. Mater. 2014, DOI: 10.1002/adma.201403532 www.advmat.de

  19. Depletion-Induced Shape and Size Selection of Gold Nanoparticles (Postprint)

    Science.gov (United States)

    2011-01-01

    the AO model18 as the product of the excluded volume, Ve, and the micellar osmotic pressure, Πm where the negative sign indicates a favorable...of Nanom- eter Gold Particles by Size-Exclusion Chromatography . Anal. Chem. 1999, 71 (11), 2085–2091. (15) Kim, F.; Song, J. H.; Yang, P...Nanorods by Controlled Overgrowth. Adv. Mater. 2008, 20 (20), 3882–3886. (30) Bakshi, M.; Kaur, I. Head-group-induced structural micellar transi- tions in

  20. Quantum Confined Semiconductors

    Science.gov (United States)

    2015-02-01

    luminescence was measured from 5 K up to 300 K using a closed-cycle refrigeration cryostat with a diamond window. Figure 61 shows the PL spectra...degrade faster than the optical properties [18]. REFERENCES [1] Porter , V. J., Mentzel, T., Charpentier, S., Kastner, M. A. and Bawendi, M. G...Characterization of high performance PbS photodetectors,” J. Optoelectronics and Adv. Mater. 10 (2), 306–310 (2008). [5] Jarosz, M. V., Porter , V

  1. Cation coordination reactions on nanocrystals: surface/interface, doping control and advanced photocatalysis applications (Conference Presentation)

    Science.gov (United States)

    Zhang, Jiatao

    2016-10-01

    Abstract: Including the shape and size effect, the controllable doping, hetero-composite and surface/interface are the prerequisite of colloidal nanocrystals for exploring their optoelectronic properties, such as fluorescence, plasmon-exciton coupling, efficient electron/hole separation, and enhanced photocatalysis applications. By controlling soft acid-base coordination reactions between cation molecular complexes and colloidal nanocrystals, we showed that chemical thermodynamics could drive nanoscale monocrystalline growth of the semiconductor shell on metal nano-substrates and the substitutional heterovalent doping in semiconductor nanocrystals. We have demonstrated evolution of relative position of Au and II-VI semiconductor in Au-Semi from symmetric to asymmetric configuration, different phosphines initiated morphology engineering, oriented attachment of quantum dots into micrometer nanosheets with synergistic control of surface/interface and doing, which can further lead to fine tuning of plasmon-exciton coupling. Therefore, different hydrogen photocatalytic performance, Plasmon enhanced photocatalysis properties have been achieved further which lead to the fine tuning of plasmon-exciton coupling. Substitutional heterovalent doping here enables the tailoring of optical, electronic properties and photocatalysis applications of semiconductor nanocrystals because of electronic impurities (p-, n-type doping) control. References: (1) J. Gui, J. Zhang*, et al. Angew. Chem. Int. Ed. 2015, 54, 3683. (2) Q. Zhao, J. Zhang*, etc., Adv. Mater. 2014, 26, 1387. (3) J. Liu, Q. Zhao, S. G. Wang*, J. Zhang*, etc., Adv. Mater. 2015, 27-2753-2761. (4) H. Qian, J. Zhang*, etc., NPG Asia Mater. (2015) 7, e152. (5) M. Ji, M. Xu, etc., J. Zhang*, Adv. Mater. 2016, in proof. (6) S. Yu, J. T. Zhang, Y. Tang, M. Ouyang*, Nano Lett. 2015, 15, 6282-6288. (7) J. Zhang, Y. Tang, K. Lee and M. Ouyang*, Science 2010, 327, 1634. (8) J. Zhang, Y. Tang, K. Lee, M. Ouyang*, Nature 2010, 466

  2. Retenção do dimetoato e sua relação com pH e teores de argila e matéria orgânica nos sedimentos da zona não-saturada de uma microbacia no nordeste paraense Dimethoate retention and its relation to pH, clay and organic mater contents by sediments in non saturated zone of a small catchment of the northeast Pará

    Directory of Open Access Journals (Sweden)

    Lilianne Maia Lima

    2007-06-01

    the Cumaru stream, Igarapé-Açu county, we evaluated the retention process of this compound in samples of the non saturated zone, as well as verified the effects of soil pH and clay and organic mater contents in this process. Among the main pesticides the farmers use in this region, dimethoate was selected for this study, due to its larger leaching potential according to the GUS (Groundwater Ubiquity Score index. A sorption experiment was carried out to evaluate the retention of the dimethoate in sediments in the non saturated zone. The experiment showed that the sorption of the dimethoate varied from 2.5% to 36.2% (initial concentration of 20 mg.l-1 and from 6.2% to 31.0% (initial concentration of 10 mg.l-1. These data demonstrate a high contamination potential of the groundwater by this compound, mainly due to its high mobility and low retention capacity. The dimethoate sorption rates were positively related to organic matter content in the sediments. On the other hand, values have an inverse relationship with the sorption rates of dimethoate, while clay content did not produce any effect on its retention.

  3. Laplace Operators of Infinite-Dimensional Lie Algebras and Theta Functions

    Science.gov (United States)

    Kac, Victor G.

    1984-01-01

    Until recently, the generalized Casimir operator constructed by Kac [Kac, V. G. (1974) Funct. Anal. Appl. 8, 68-70] has been the only known element of the center of a completion of the enveloping algebra of a Kac-Moody algebra. It has been conjectured [Deodhar, V. V., Gabber, O. & Kac, V. G. (1982) Adv. Math. 45, 92-116], however, that the image of the Harish-Chandra homomorphism contains all theta functions defined on the interior of the complexified Tits cone and hence separates the orbits of the Weyl group. Developing the ideas of Feigin and Fuchs [Feigin, B. L. & Fuchs, D. B. (1983) Dokl. Akad. Nauk SSSR 269, 1057-1060], I prove this conjecture. Another application of this method is the Chevalley type restriction theorem for simple finite-dimensional Lie superalgebras.

  4. Screening for antibodies against Aleutian disease virus (ADV) in mink. Elucidation of dubious results by additive counterimmunoelectrophoresis

    DEFF Research Database (Denmark)

    Uttenthal, Åse

    1992-01-01

    In order to distinguish true positive results in counterimmunoelectrophoresis from false positive ones an additive counterimmunoelectrophoresis was developed. The method was tested on selected mink serum samples as part of a routine testing for antibodies towards Aleutian disease virus on 3 million...... blood samples. The procedure of the method is, that a known positive serum sample is mixed with the patient serum to be tested. The result from a false positive sample will be one precipitin line towards virus and one nonspecific line. If the serum sample is a true positive one, the antibodies...... originating from the patient serum will be added to the antibodies in the standard positive serum giving only one precipitin line. The system is further extended by testing the serum samples towards an antigen preparation containing all the cellular components but free from virus....

  5. Os advérbios já, mais e ainda nas orações negativas

    Directory of Open Access Journals (Sweden)

    Maria Angélica Furtado Cunha

    2012-02-01

    Full Text Available This paper follows a functional approach which takes into account the real use of language as an instrument of communication. We are malnly lnterested ln lnvestigating the ways through whlch syntax, semantics and pragmatics interact. ln order to do this, we study the behaviour of the adverbs já, mais and ainda ln negative sentences. First, we review the use of some elements which reinforce the very idea of negation. Secondly, we deal, specifically, with the adverbs, já, mais and ainda as a reinforcement to the negative. Thirdly, we aim at verifying their behaviour from an argumentative perspective. Finally, we present our conclusions.

  6. Adv. Simulation for Additive Manufacturing: 11/2014 Wkshp. Report for U.S. DOE/EERE/AMO

    Energy Technology Data Exchange (ETDEWEB)

    Turner, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Babu, Sudarsanam Suresh [Univ. of Tennessee, Knoxville, TN (United States); Blue, Craig A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-07-01

    The overarching question for the workshop was as following: How do we best utilize advanced modeling and high-performance computing (HPC) to address key challenges and opportunities in order to realize the full potential of additive manufacturing; and what are the key challenges of additive manufacturing to which modeling and simulation can contribute solutions, and what will it take to meet these challenges?

  7. Coming Home: "Hermanos Academicos" Reflect on Past and Present Realities as Professors at Their Alma Mater

    Science.gov (United States)

    Reddick, Richard J.; Saenz, Victor B.

    2012-01-01

    In this article, Richard J. (Rich) Reddick and Victor B. Saenz, two assistant professors of color, utilize scholarly personal narrative to reflect on their trajectory from undergraduates at a predominantly White institution--one prominently mired in a legacy of discrimination and exclusion toward people of color--to faculty members at that same…

  8. Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction

    NARCIS (Netherlands)

    Nakagomi, Takayuki; Molnar, Zoltan; Nakano-Doi, Akiko; Taguchi, Akihiko; Saino, Orie; Kubo, Shuji; Clausen, Martijn; Yoshikawa, Hiroo; Nakagomi, Nami; Matsuyama, Tomohiro

    2011-01-01

    Increasing evidence shows that neural stem/ progenitor cells (NSPCs) can be activated in the nonconventional neurogenic zones such as the cortex following ischemic stroke. However, the precise origin, identity, and subtypes of the ischemia-induced NSPCs (iNSPCs), which can contribute to cortical neu

  9. Talis mater, talis filia: las malas madres en los siglos XVI y XVII

    Directory of Open Access Journals (Sweden)

    Amaia Nausia Pimoulier

    2013-12-01

    Full Text Available Este artículo presenta un tipo de violencia familiar protagonizado por madres e hijas navarras de los siglos XVI y XVII. Las acu-saciones por lenocinio o alcahuetería contra las madres que emplearon a sus propias hijas en sus tratos de mediadoras sirven para ilustrar una forma de violencia que supone, entre otras cosas, una ruptura del amor materno. La preca-ria situación de la madre y las dificultades tras el fallecimiento del esposo —la gran parte de los casos están protagonizados por madres viu-das— fue el contexto general en el que se desarrollaron los malos tratos. La historia de estas mujeres representa un mal ejercicio de la autoridad materna y una forma de violencia hacia las hijas; una violencia no siempre física, pero sí emocional y psicológica.

  10. Cross-Modal Associations between Materic Painting and Classical Spanish Music

    Directory of Open Access Journals (Sweden)

    Liliana eAlbertazzi

    2015-04-01

    Full Text Available The study analyses the existence of cross-modal associations in the general population between a series of paintings and a series of clips of classical (guitar music. Because of the complexity of the stimuli, the study differs from previous analyses conducted on the association between visual and acoustic stimuli, which predominantly analysed single tones and colours by means of psychophysical methods and forced choice responses. More recently, the relation between music and shape has been analyzed in terms of music visualization, or relatively to the role played by emotion in the association, and free response paradigms have also been accepted. In our study, in order to investigate what attributes may be responsible for the phenomenon of the association between visual and acoustic stimuli, the clip/painting association was tested in two experiments: the first used the semantic differential on a unidimensional rating scale of adjectives; the second employed a specific methodology based on subjective perceptual judgments in first person account. Because of the complexity of the stimuli, it was decided to have the maximum possible uniformity of style, composition and musical colour. The results show that multisensory features expressed by adjectives such as ‘quick’, ‘agitated’, and ‘strong’, and their antonyms ‘slow’, ‘calm’, and ‘weak’ characterized both the visual and acoustic stimuli, and that they may have had a role in the associations. The results also suggest that the main perceptual features responsible for the clip/painting associations were hue, lightness, timbre, and musical tempo. Contrary to what was expected, the musical mode usually related to feelings of happiness or to feelings of sadness and spatial orientation did not play a significant role in the association. The main result of the study consists in showing the existence of cross-modal associations between high complex stimuli.

  11. Intraventricular pneumocephalus after accidental perforation of the dura mater. Case report

    OpenAIRE

    2006-01-01

    JUSTIFICATIVA E OBJETIVOS: O uso de ar para a realização do teste da perda da resistência com a finalidade de identificar o espaço peridural é extremamente difundido no mundo inteiro, porém uma das complicações possíveis é a perfuração acidental de dura-máter que apresenta incidência estimada entre 1% e 2%. O objetivo deste relato foi descrever um caso de paciente com pneumoencéfalo intraventricular após perfuração acidental de dura-máter usando a técnica da perda da resistência com ar. RELAT...

  12. Factors Associated with Non-Traditional and Traditional Undergraduate Alumni Giving to Alma Maters

    Science.gov (United States)

    Johnson, Elizabeth Ann Miller

    2013-01-01

    Both public and private institutions of higher education face revenue shortfalls. In order to close budget gaps, colleges and universities must identify new revenue sources. Historically alumni are large providers of voluntary support to higher education institutions, but the numbers of alumni contributing financially is decreasing. The purpose of…

  13. Use of equine pericardium sheet (LYOMESH®) as dura mater substitute in endoscopic endonasal transsphenoidal surgery

    OpenAIRE

    Cavallo, Luigi M.; Solari, Domenico; Somma, Teresa; Di Somma, Alberto; Chiaramonte, Carmela; Cappabianca, Paolo

    2013-01-01

    Objective: The aim of this study was to describe the use of equine pericardium sheet (Lyomesh®) as dural substitute for sellar reconstruction after endoscopic endonasal transsphenoidal surgery for the removal of pituitary adenomas. Methods: We reviewed data of patients that underwent surgery by means of an endoscopic endonasal transsphenoidal approach for the removal of pituitary adenomas over a 12-months period, starting in May 2012, i.e. when we adopted Lyomesh® (Audio Technologies, Pia...

  14. Hail to Thee, Our Alma Mater: Alumni Role Identity and the Relationship to Institutional Support Behaviors

    Science.gov (United States)

    McDearmon, J. Travis

    2013-01-01

    With the decline in state and federal support for higher education continuing to plague colleges and universities across the U.S., many institutions are looking to increase the levels of support annually received from alumni and other constituencies. Research on alumni relations in American colleges and universities has historically focused on…

  15. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain

    Energy Technology Data Exchange (ETDEWEB)

    Markowitz, S.; Saito, K.; Moskowitz, M.A.

    1987-12-01

    Utilizing /sup 125/I-BSA administered intravenously, a simple, reliable, and sensitive method was established for the detection of plasma protein extravasation in the dura of rats and guinea pigs following chemical, electrical, or immunological stimulation. Extravasated /sup 125/I-BSA or Evans blue was noted in the dura and conjunctiva but not in the temporalis muscle of saline-perfused rats following intravenous capsaicin, 1 mumol/kg. Capsaicin-induced extravasation was mediated by unmyelinated and small myelinated fibers since leakage did not develop in adult animals in whom these fibers were destroyed by capsaicin pretreatment (50 mg/kg) as neonates. An ipsilateral increase in Evans blue and /sup 125/I-BSA was found in the dura, eyelids, lips and gingival mucosa, and snout following electrical stimulation of the rat trigeminal ganglion. This increase was also C-fiber dependent. Among those peptides contained in perivascular afferent fibers and administered intravenously, substance P (SP) and neurokinin A (NKA), but not calcitonin gene-related peptide, caused a dose-dependent extravasation in the dura and conjunctiva of rats. Neonatal capsaicin pretreatment did not attenuate SP- nor NKA-induced effects in the dura and actually increased extravasation in the conjunctiva. Intravenous administration of 5-HT or bradykinin to normal adult rats or adult rats pretreated as neonates with capsaicin increased levels of /sup 125/I-BSA in both the dura and the conjunctiva. Histamine and prostaglandin E2, on the other hand, caused protein leakage in the conjunctiva but not in the dura of rats; however, histamine did induce extravasation in the dura of guinea pigs.

  16. Interface engineering in inorganic hybrid structures towards improved photocatalysis (Conference Presentation)

    Science.gov (United States)

    Xiong, Yujie

    2016-10-01

    Designing new photocatalytic materials for improving photoconversion efficiency is a promising route to alleviate the steadily worsening environmental issues and energy crisis. Despite the invention of a large number of catalytic materials with well-defined structures, their overall efficiency in photocatalysis is still quite limited as the three key steps - light harvesting, charge generation and separation, and charge transfer to surface for redox reactions - have not been substantially improved. To improve each step in the complex process, there is a major trend to develop materials based on inorganic hybrid structures. In this case, interface engineering holds the promise for boosting the overall efficiency, given the key roles of interface structures in charge and energy transfer. In this talk, I will demonstrate several different approaches to designing inorganic hybrid structures with improved photocatalytic performance via interface engineering. The typical demonstrations include semiconductor-plasmonics systems for broad-spectrum light harvesting, metal-semiconductor interfaces for improved charge separation, semiconductor-MOF (metal-organic framework) configurations for activated surface reactions. It is anticipated that this series of works open a new window to rationally designing inorganic hybrid materials for photo-induced applications. References: (1) Bai, S.; Yang, L.; Wang, C.; Lin, Y.; Lu, J.; Jiang, J. and Xiong, Y.*, Angew. Chem. Int. Ed. 54, 14810-14814 (2015). (2) Bai, S.; Jiang, J.; Zhang, Q. and Xiong, Y.*, Chem. Soc. Rev. 44, 2893-2939 (2015). (3) Bai, S.; Li, X.; Kong, Q.; Long, R.; Wang, C.; Jiang, J. and Xiong, Y.*, Adv. Mater. 27, 3444-3452 (2015). (4) Bai, S.; Ge, J.; Wang, L.; Gong, M.; Deng, M.; Kong, Q.; Song, L.; Jiang, J.;* Zhang, Q.;* Luo, Y.; Xie, Y. and Xiong, Y.*, Adv. Mater. 26, 5689-5695 (2014). (5) Li, R.; Hu, J.; Deng, M.; Wang, H.; Wang, X.; Hu, Y.; Jiang, H. L.; Jiang, J.;* Zhang, Q.;* Xie, Y. and Xiong, Y.*, Adv. Mater

  17. High Performance Organic Materials and Devices

    Science.gov (United States)

    2006-03-31

    Testing was done in N 2 under simulated AM1.5G irradiation (100 mW/cm 2) using xenon - lamp based solar simulator (Oriel 96000 150W Solar Simulator). The...use in memory devices," Adv. Mater. 17, 1440 (2005). 9. G. Li, V. Shrotriya, Y. Yao and Y. Yang. "Investigation of annealing effects and film thickness...different J-V curves correspond to the devices with active layer before (#1), and after thermal annealing at 1 10’C for 10 min (#2), 20 min (#3), and

  18. Layer-by-Layer Self-Assembly of Plexcitonic Nanoparticles

    Science.gov (United States)

    2013-08-12

    Gearheart, and C. J. Murphy, “Wet chemical synthesis of silver nanorods and nanowires of controllable aspect ratio,” Chem. Commun. (Camb.) 0(7), 617–618... synthesis of high-aspect-ratio gold nanorods ,” J. Adv. Mater. 15(5), 414–416 (2003). 19. Q. Zhang, N. Li, J. Goebl, Z. Lu, and Y. Yin, “A Systematic...Study of the Synthesis of Silver Nanoplates: Is Citrate a “Magic” Reagent?” J. Am. Chem. Soc. 133(46), 18931–18939 (2011). 20. N. R. Jana, L

  19. Topological Insulators and Superconductors for Innovative Devices

    Science.gov (United States)

    2015-03-20

    Ong , and R. J. Cava, Phys. Rev. Lett. 104, 057001 (2010). [12] S. Sasaki, M. Kriener, K. Segawa, K. Yada, Y. Tanaka, M. Sato, and Y. Ando, Phys. Rev...Baumberger , C. R. A. Catlow , Adv. Mater. 2012 , 24 , 2154 . [ 7 ] D. X. Qu , Y. S. Hor , J. Xiong , R. J. Cava , N. P. Ong ...Xiong, R. J. Cava, and N. P. Ong , Science 329, 821 (2010). [6] Z. Ren, A.A. Taskin, S. Sasaki, K. Segawa, and Y. Ando, Phys. Rev. B 82, 241306(R

  20. Truly Nonionic Polymer Shells for the Encapsulation of Living Cells

    Science.gov (United States)

    2011-07-04

    Tsukruk, Adv. Mater. 2006, 18, 829. [23] C. Jiang, V. V. Tsukruk, Soft Matter 2005, 1, 334. [24] A. A. Mamedov, N. A. Kotov, M. Prato, D. M. Guldi, J. P... Soft Matter 2009, 5, 4077. [48] C. R. Kinnane, G. K. Such, G. Antequera-Garcia, Y. Yan, S. J. Dodds, L. M. Liz-Marzan, F. Caruso, Biomacromolecules 2009...Zhang, L. Ge, H. Chi, Bull. Chem. Soc. Jpn. 2008, 81, 906. [79] V. Kozlovskaya, E. Kharlampieva, I. Drachuk, D. Cheng, V. V. Tsukruk, Soft Matter 2010

  1. A 10,000-Pen Nanoplotter with Integrated Ink Delivery System

    Science.gov (United States)

    2007-03-03

    Nanolithography," IEEE/ASME Journal of Microelectromechanical Systems, 2004, 13(4), 594-602. 3. Chung, S.–W.; Ginger , D.S.; Morales, M.; Zhang, Z...Nanolithography and a Sol-Based Ink,” Nano Lett. 2003, 3, 757-760. 5. Ginger , D.S.; Zhang, H.; Mirkin, C.A. “The Evolution of Dip-Pen... Nanoparticles Based on Thermally Addressable DNA Interconnects,” Adv. Mater., 2006, 18, 2304-2306. 8. Jin, R.; Cao, Y.C., Thaxton, C.S.; Mirkin, C.A

  2. High-pressure high-temperature synthesis and structure of α-tetragonal boron

    Directory of Open Access Journals (Sweden)

    Evgeny A Ekimov and Igor P Zibrov

    2011-01-01

    Full Text Available ERRATUMThis is an Erratum for the article 2011 Sci. Technol. Adv. Mater. 12 055009The publisher regrets that there is a typographical error on page 2 of this article. The fourth sentence of section 3 should read as follows:The lines characteristic of B–H–B (1700–2000 cm-1 and B–H (2550–2650 cm-1 bonds of decaborane were not found in the Raman spectra of the crystals (figure 3 that confirms the complete decomposition of decaborane [19, 20].

  3. Directed assembly of nanoparticles monitored by liquid crystal topological defects for advanced optical properties of the composites (Conference Presentation)

    Science.gov (United States)

    Lacaze, Emmanuelle

    2016-09-01

    Directed assembly of nanoparticles is a promising alternative for original nanoparticle organizations. New kinds of optical properties are expected when semi-conductive or metallic nanoparticles are concerned. Using liquid crystal matrices oriented by their interfaces, it is possible to induce anisotropic nanoparticle organizations. We can then investigate the influence of these matrices on the optical properties of the nanoparticles. I will show how to create hierarchical arrays of oriented topological defects in thin smectic films that act as efficient traps for a specific localization and orientation of nanoparticles [1]. I will show how specific nanoparticle assemblies can be obtained, depending on the nanoparticle size and shape. Fluorescent nanorods trapped in smectic dislocations become strictly oriented along a single direction, providing, a fine control of the polarization of the emmitted single photons [2]. Similarly the orientation of gold nanorods leads to the control of their luminescence as well as of their plasmon resonance by light polarization. I will show that, when the nanoparticle concentration is increased, single chains are formed, and can lead to a strong anisotropic electromagnetic coupling between the particles [3]. We are not only capable of linearly confining the particles, but also of varying the inter-particle interactions and thus modifing their optical properties which are sensitive to the inter-particle distance [4]. [1] D. Coursault, Soft Matter 12 (2016) 629. [2] L. Pelliser et al, Adv. Funct. Mat. 25 (2015) 1719. [3] D. Coursault et al., Adv. Mat. 24 (2012) 1461. [4] D. Coursault et al., ACSNano 9 (2015) 11678.

  4. A dor durante a punção do canal vertebral e sua relação com a inervação do ligamento amarelo, da dura-máter e do ligamento longitudinal posterior El dolor durante la punción del canal vertebral y su relación con la inervación del ligamento amarillo, de la dura-máter y del ligamento longitudinal posterior Pain during spinal canal puncture and its relationship with ligamentum flavum, dura-mater and posterior longitudinal ligament innervation

    Directory of Open Access Journals (Sweden)

    Edmundo Zarzur

    2004-12-01

    influence of general anesthesia and that is why blockade with conscious patients is advisable. Pain is only referred when needle or catheter tip bypass the medium sagital plane to reach the antero-lateral epidural compartment, thus being able to touch nervous rootlets close to intervertebral foramina. Except for studies on skin, subcutaneous tissue and interspinous ligament innervation, this study aimed at reviewing the innervation of some spinal canal structures, namely, ligamentum flavum, posterior longitudinal ligament, dura-mater and intervertebral disk. CONTENTS: Studies on spinal canal innervation are presented in this literature review, aiming at understanding pain during spinal puncture. CONCLUSIONS: Ligamentum flavum is not innervated, thus explaining lack of pain during puncture. Other pains during puncture may be attributed to Luschka's nerve, which innervates posterior longitudinal ligament and dural ventral portion.

  5. Lasing and macroscopic coherence of periodic 2D and 3D microstructures in organic microcavities (Conference Presentation)

    Science.gov (United States)

    Mischok, Andreas; Wagner, Tim; Brückner, Robert; Sudzius, Markas; Fröb, Hartmut; Lyssenko, Vadim G.; Leo, Karl

    2016-09-01

    Two of the most successful microresonator concepts are the vertical cavity surface emitting laser (VCSEL), comprising a vertical cavity of highly reflective DBRs sandwiching an active layer, and the distributed feedback (DFB) laser, where a periodic optical grating selects laser modes from an active waveguide (WG) layer. Here, an organic microcavity is coupled with in-plane periodic photonic wires or dots to facilitate a coherent interaction between waveguided and vertically emitting modes as well as creating an additional in-plane confinement. The vertical positioning of such patterning plays a crucial role in the observable features. While embedding metallic or dielectric wires directly in the cavity layer leads to a strong lateral confinement as well as the observation of photonic Bloch states [1,2], the deposition of the full VCSEL stack on top of a periodic grating reveals novel features. In such a device, we demonstrate the coherent coupling between parabolic VCSEL and linear WG modes in the angle-resolved far field emission. In this system, lasing occurs not only at the VCSEL parabola apex but also at points of hybridization, when the dispersion of modes cross, showing a drastically enhanced in-plane coherence [3]. The coherent coupling of two conceptually different devices with perpendicular propagation directions paired with the macroscopic coherence facilitate a multitude of new applications. [1] Adv. Opt. Mater. 2(8), 746 (2014) [2] Phys. Rev. Appl. 3, 064016 (2015). [3] Adv. Opt. Mater. under review (2016).

  6. Graphene sheets stacked polyacrylate latex composites for ultra-efficient electromagnetic shielding

    Science.gov (United States)

    Li, Yong; Zhang, Song; Ni, Yuwei

    2016-07-01

    Graphene sheets (GS) are at the forefront of electromagnetic interference (EMI) shielding/attenuation materials science research because of their excellent electrical properties (Wen B et al 2014 Adv. Mater. 26 3484, Zhang Y et al 2015 Adv. Mater. 27 2049). GS/polyacrylate (PA) composites were prepared using a solvent-free latex technology, which favored the build-up of a segregated GS architecture stacked in the polymer matrix. GS were obtained from graphite flakes (GF) via a mechanical delamination approach in water. The microstructure, electrical, dielectric and electromagnetic shielding properties of the GS/PA composites were correlated in this manuscript. A remarkably low percolation threshold of ˜0.11 mass per cent for room-temperature electrical conductivity was obtained in the GS/PA composites owing to the stacked architecture of GS with high aspect ratios. This unique nanostructured GS architecture not only enhanced the electrical conductivity of composites, but also dramatically increased complex permittivity by inducing strong Maxwell-Wagner-Sillars (MWS) polarization at the highly conductive GS/non-conductive PA interfaces. The EMI shielding effectiveness (SE) of these composites was enhanced with increasing GS content, and the composite with 6 wt% GS loading exhibited a high EMI SE of ˜66 dB over a frequency of 8.2-12.4 GHz, resulting from the pronounced conduction loss, dielectric relaxation, and multi-scattering.

  7. Therapy dura mater spinalis abscess research progress%硬脊膜外脓肿的研究进展

    Institute of Scientific and Technical Information of China (English)

    付霜; 倪家骧

    2010-01-01

    脊髓硬脊膜外脓肿(spinal epidural abscess,SEA)是神经外科少见的急症之一,临床误诊率及致残率均较高.本文详细评估和分析了自1985年以来发表的关于SEA的文献,尤其是患者因椎管内麻醉发展而来的病例分析.从流行病学,发病机理和高危因素,临床表现和实验室检查,诊断以及治疗等方面简单概括SEA的特点.

  8. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    Energy Technology Data Exchange (ETDEWEB)

    Chardonnet, Pascal [Coordinator IRAP PhD EMJD, Université de Nice 28, avenue Valrose 06103 Nice (France); LAPTh, Université de Savoie, CNRS, B.P. 110, Annecy-le-Vieux F-74941 (France); ICRANet, Piazza della Repubblica 10, 65122 Pescara (Italy); Department for Theoretical Nuclear Physics, National Research Nuclear University Moscow Engineering Physics Institute, MEPhI, Moscow (Russian Federation)

    2015-12-17

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d’Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet the extra-European connections with Brazil, China and India will be guaranteed: in China, with the Shanghai Observatory of the Chinese Academy of Science, studying the formation and evolution of large-scale structure and galaxies; in India, with the Indian Centre for Space Physics (ICSP), renowned for its research on compact objects as well as on solar physics and astrochemistry; in Brazil with ICRANet Brazil where a successful program of research and teaching in relativistic astrophysics has been established in recent years.

  9. Efeito da quercetina sobre o extravasamento plasmático no sistema nervoso dura-mater de ratos

    Directory of Open Access Journals (Sweden)

    Luiz Arthur Rangel Cyrino

    2002-01-01

    Full Text Available Estudos recentes têm demonstrado que os bioflavonóides afetam vários sistemas enzimáticos nos mamíferos. A dura-máter é um tecido que recebe inervação peptidérgica. No cérebro, a inflamação neurogênica envolve a liberação da substância P (SP por terminais nervosos sensoriais e é modulada pela endopeptidase neutra (NEP e pela enzima conversora da angiotensina (ECA. Neste estudo, avaliamos o efeito da quercetina, que representa mais de 50% dos bioflavonóides, sobre o extravasamento plasmático induzido pela SP em tecidos selecionados no sistema nervoso central de ratos e dura-máter. Também examinamos o efeito da inibição seletiva das enzimas metabolizadoras da SP (NEP e ECA. A administração de SP (10 nmol/kg e 30 nmol/kg, i.v. aumentou o extravasamento plasmático de maneira dose dependente na duramáter, não apresentando nenhum efeito nos outros tecidos; este efeito foi potencializado por inibidores seletivos da NEP e da ECA. A quercetina (30 mg/kg v.o. aumentou o extravasamento plasmático em relação ao controle em todos os tecidos. O prétratamento com quercetina potenciou significativamente o extravasamento plasmático induzido pela SP (10 nmol/kg na dura-máter. Resultados obtidos com o pré-tratamento com antagonistas específicos para receptores da substância P e bradicinina (NK-1 e B2 sugerem que o aumento do extravasamento plasmático induzido pela quercetina e a potenciação da resposta à SP foram devidos ao acúmulo deste neuropeptídeo na dura-máter.

  10. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    Science.gov (United States)

    Chardonnet, Pascal

    2015-12-01

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d'Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet the extra-European connections with Brazil, China and India will be guaranteed: in China, with the Shanghai Observatory of the Chinese Academy of Science, studying the formation and evolution of large-scale structure and galaxies; in India, with the Indian Centre for Space Physics (ICSP), renowned for its research on compact objects as well as on solar physics and astrochemistry; in Brazil with ICRANet Brazil where a successful program of research and teaching in relativistic astrophysics has been established in recent years.

  11. Poliitikud võtavad alma mater'i üle / Alar Karis ; küsitlenud Nils Niitra

    Index Scriptorium Estoniae

    Karis, Alar, 1958-

    2010-01-01

    Edaspidi peaks valima rektorit 11-liikmeline nõukogu, kuhu kuuluvad inimesed väljastpoolt ülikooli. Oma arvamust selle kohta avaldavad Tallinna Ülikooli rektor Rein Raud, Tartu Ülikooli professor Talis Bachmann ja professor Mati Kilp

  12. EDITORIAL: Nanomemory: information and ingenuity Nanomemory: information and ingenuity

    Science.gov (United States)

    Demming, Anna

    2013-04-01

    Adv. Funct. Mater 20 330-7 [11] Bose S, Kim N H, Kuila T, Lau K-T and Lee J H 2011 Electrochemical performance of a graphene-polypyrrole nanocomposite as a supercapacitor electrode Nanotechnology 22 295202 [12] Loomis J, King B, Burkhead T, Xu P, Bessler N, Terentjev E and Panchapakesan B 2012 Graphene-nanoplatelet-based photomechanical actuators Nanotechnology 23 045501 [13] Finn C A 2001 Artifacts: An Archaeologist's Year in Silicon Valley (Cambridge, MA: MIT Press)

  13. Approach to tune near- and far-field properties of hybrid dimer nanoantennas via laser melting at the nanoscale

    CERN Document Server

    Sun, Yali; Zuev, Dmitry; Huang, Lirong; Krasnok, Alexander; Belov, Pavel

    2016-01-01

    Asymmetric metal-dielectric nanostructures are demonstrated superior optical properties arise from the combination of strong enhancement of their near fields and controllable scattering characteristics which originate from plasmonic and high-index dielectric components. Here, being inspired by the recent experimental work [Dmitry~Zuev, \\textit{et al.}, Adv. Mater. \\textbf{28}, 3087 (2016)] on a new technique for fabrication of asymmetric hybrid nanoparticles via femtosecond laser melting at the nanoscale, we suggest and study numerically a novel type of hybrid dimer nanoantennas. The nanoantennas consist of asymmetric metal-dielectric (Au/Si) nanoparticles and can allow tuning of the near- and far-field properties via laser melting of the metal part. We demonstrate a modification of scattering properties, near electric field distribution, normalized local density of states, and power patters of radiation of the nanoantennas upon laser reshaping. The parameters used to investigate these effects correspond to e...

  14. Electroluminescence from charge transfer states in Donor/Acceptor solar cells

    DEFF Research Database (Denmark)

    Sherafatipour, Golenaz; Madsen, Morten

    charge transfer (CT) excitons, which is Coulombically bound interfacial electron- hole pairs residing at the donor/acceptor heterojunctions. The CT state represents an intermediate state between the exciton dissociation and recombination back to the ground state. Since the recombination of photo...... at the donor/acceptor interface is detected. As a less studied system, we examine here the interfacial charge transfer state recombination in DBP:C70 thin-films. The weak EL from the small molecule solar cell biased in the forward direction gives valuable information about the CT state recombination, from...... which the maximum open-circuit voltage can be estimated, and further can be used in the modeling and optimization of the OPV devices. [1] C. Deibe, T. Strobe, and V. Dyakonov, “Role of the charge transfer state in organic donor-acceptor solar cells,” Adv. Mater., vol. 22, pp. 4097–4111, 2010. [2] K...

  15. Dominance of interface chemistry over the bulk properties in determining the electronic structure of epitaxial metal/perovskite oxide heterojunctions

    Energy Technology Data Exchange (ETDEWEB)

    Chambers, Scott A.; Du, Yingge; Gu, Meng; Droubay, Timothy C.; Hepplestone, Steven; Sushko, Petr

    2015-06-09

    We show that despite very similar crystallographic properties and work function values in the bulk, epitaxial Fe and Cr metallizations on Nb:SrTiO3(001) generate completely different heterojunction electronic properties. Cr is Ohmic whereas Fe forms a Schottky barrier with a barrier height of 0.50 eV. This contrast arises because of differences in interface chemistry. In contrast to Cr [Chambers, S. A. et al., Adv. Mater. 2013, 25, 4001.], Fe exhibits a +2 oxidation state and occupies Ti sites in the perovskite lattice, resulting in negligible charge transfer to Ti, upward band bending, and Schottky barrier formation. The differences between Cr and Fe are understood by performing first-principles calculations of the energetics of defect formation which corroborate the observed interface chemistry and structure.

  16. First Principles Study of Dopant Site Selectivity in Ordered Perovskite CaCu3Ti4O12

    Institute of Scientific and Technical Information of China (English)

    XU Li-Chun; WANG Ru-Zhi; DENG Yang; YAN Hui

    2011-01-01

    We investigate the dopant site selectivity of CaCu3Ti4O12(CCTO) using the first principles calculations. Our results show that, for four cases of possible occupancy by La atom, lattice expansions and formation enthalpies with different dopant quantities indicate that doped La cations are preferentially substituted for Ca sites in CaCu3Ti4O12, which is excellent in agreement with the experimental observation(Choi et al. Adv. Mater. 21 (2009) 885).Furthermore, more interesting information of doping is also explored by the analysis of density of states and it is found that La substituting for Cu may advance the electron conduction in CCTO. It supplies a potential solution for limitations of CCTO devices by exploring the effect when La substitutes for Cu sites in the CCTO crystal.

  17. Stories of Feng Lin whose dissertation Is one of the national excellent doctoral dissertations%百篇优秀博士论文入选者冯琳小记

    Institute of Scientific and Technical Information of China (English)

    魏沛; 李晓娟

    2006-01-01

    @@ 冯琳说:"我是一个喜欢科研的普通学生." 2003年,在她博士三年级的时候,她曾在中国科学院研究生院作报告,当时的简介: 冯琳,女,1976年生.2000年9月起在中科院化学研究所攻读博士学位,师从江雷研究员,主要从事功能纳米界面材料的制备和研究工作,现已在世界著名化学期刊Angew. Chem.Int.Ed.上发表论文5篇,被Adv.Mater.主编约稿1篇,三年内发表文章影响因子总和超过30,申请专利4项.

  18. Conjugated Polymers for Energy Production

    DEFF Research Database (Denmark)

    Livi, Francesco

    arylation (DAr) and direct arylation polymerization (DArP) have been applied to the preparation of PPDTBT, making this polymer readily available in only 4 synthetic steps and thus easily transferable to a large scale-production setup. DArP avoids organometallic species and therefore is an appealing......This dissertation is aimed at developing materials for flexible, large area, ITO-free polymer solar cells (PSCs) fully printed under ambient conditions. A large screening of conjugated polymers, both novel and well-known materials, has been carried out in order to find suitable candidates...... for scalable PSCs fully printed under ambient conditions [Adv. Energy Mater. 2015, 5, 1402186]. PPDTBT resulted to be the conjugated polymer with the best photovoltaic performance within the 104 synthesized macromolecules. Therefore, further studies have been done on such material. The impact of side chain...

  19. Particle processing technology

    Science.gov (United States)

    Yoshio, Sakka

    2014-02-01

    . Mater. 12 013001 [3] Sakka Y and Uchikoshi T 2010 KONA Powder Particle J. 28 74 (kona.or.jp/search/28_074.pdf) [4] Naguib M, Mashtalir O, Carle J, Presser V, Lu J, Hultman L, Gogotsi Y and Barsoum M W 2012 ACS Nano 6 1322 [5] Sakka Y and Suzuki T S 2005 J. Ceram. Soc. Japan 113 26 [6] Grasso S, Sakka Y and Maizza G 2009 Sci. Technol. Adv. Mater. 10 053001 [7] Nakao H, Tokonami S, Hamada T, Shiigi H, Nagaoka T, Iwate F and Takeda Y 2012 Nanoscale 4 6814 [8] Miyazawa K and Hotta K 2010 J. Cryst. Growth 312 2764 [9] Suehiro T, Xie R and Hirosaki N 2013 Indust. Eng. Chem. Res. 52 7453 [10] Zhu Q, Li J-G, Li X, Sun X and Sakka Y 2011 Sci. Technol. Adv. Mater. 12 055001 [11] Li J, Li J-G, Zhang Z, Wu X, Liu S, Li X, Sun X and Sakka Y 2012 Sci. Technol. Adv. Mater. 13 035007 [12] Kawamura F, Yusa H and Taniguchi T 2012 Appl. Phys. Lett. 100 251910 [13] Watanabe K and Taniguchi T 2011 Int. J. Appl. Ceram. Technol. 8 977 [14] Deng Z-Y, Ferreira J M F and Sakka Y 2008 J. Am. Ceram. Soc. 91 3825 [15] Uda M, Okuyama H, Suzuki T S and Sakka Y 2012 Sci. Technol. Adv. Mater. 13 025009 [16] Takeya H, Kato R, Wakahara T, Miyazawa K, Yamaguchi T, Ozaki T, Okazaki H and Takano Y 2013 Mater. Res. Bull. 48 343 [17] Wakahara T, D'Angelo P, Miyazawa K, Nemoto Y, Ito O, Tanigaki N, Bradley D D C and Anthopoulos T D 2012 J. Am. Chem. Soc. 134 7204 [18] Wiecinska P, Sakka Y, Suzuki T S, Uchikoshi T, Mizerski T and Szafran M 2013 J. Ceram. Soc. Japan 121 89 [19] Kawakita M, Uchikoshi T, Kawakita J and Sakka Y 2009 J. Am. Ceram. Soc. 92 984 [20] Hu C, Sakka Y, Grasso S, Nishimura T, Guo S and Tanaka H 2011 Scr. Mater. 64 765 [21] Hu C, Sakka Y, Nishimura T, Guo S, Grasso S and Tanaka H 2011 Sci. Technol. Adv. Mater. 12 044603 [22] Kakisawa H and Sumitomo T 2011 Sci. Technol. Adv. Mater. 12 064710 [23] Grasso S, Hu C F, Maizza G, Kim B N and Sakka Y 2011 J. Am. Ceram. Soc. 94 1405 [24] Grasso S, Kim B N, Hu C F, Maizza G and Sakka Y 2010 J. Am. Ceram. Soc. 93 2460 [25] Zhang H B, Kim B N, Morita K

  20. Retraction Statement: "High-Volumetric Performance Aligned Nano-Porous Microwave Exfoliated Graphite Oxide-based Electrochemical Capacitors" and "Aligned Nano-Porous Microwave Exfoliated Graphite Oxide Ionic Actuators with High Strain and Elastic Energy Density".

    Science.gov (United States)

    2016-11-01

    These articles first published on 15 August 2013 and 21 August 2013 on the Wiley Online Library have been retracted at the request of the Research Integrity Officer (RIO) of The Pennsylvania State University, in agreement with the corresponding authors, the journal's Editor-in-Chief, and Wiley-VCH Verlag GmbH & Co. KGaA, because portions of the reported results cannot be considered reliable or reproducible. Following an investigation by the RIO of The Pennsylvania State University, it was found that the data in Figure 2a,b and Figure S1a,b (Supporting Information) of the article with DOI: 10.1002/adma.201301243, and Figure S3 (Supporting Information) of the article with DOI: 10.1002/adma.201301370 were falsified. Data regarding the carbon electrode material, A-aMEGO, reported to have a density of 1.15 g cm(-3) , in the article with DOI: 10.1002/adma.201301243, were falsified. The RIO of The Pennsylvania State University confirms that the investigation found that the mentioned data were falsified by the first author. No findings of research misconduct were made against the co-authors of these publications. [1] M. Ghaffari, Y. Zhou, H. Xu, M. Lin, T. Y. Kim, R. S. Ruoff, Q. M. Zhang, Adv. Mater. 25: 2013, 4879. doi:10.1002/adma.201301243 [2] M. Ghaffari, W. Kinsman, Y. Zhou, S. Murali, Q. Burlingame, M. Lin, R. S. Ruoff, Q. M. Zhang, Adv. Mater. 25: 2013, 6277. doi:10.1002/adma.201301370.

  1. Photoinduced Electron Transfer in the Strong Coupling Regime: Waveguide-Plasmon Polaritons.

    Science.gov (United States)

    Zeng, Peng; Cadusch, Jasper; Chakraborty, Debadi; Smith, Trevor A; Roberts, Ann; Sader, John E; Davis, Timothy J; Gómez, Daniel E

    2016-04-13

    Reversible exchange of photons between a material and an optical cavity can lead to the formation of hybrid light-matter states where material properties such as the work function [ Hutchison et al. Adv. Mater. 2013 , 25 , 2481 - 2485 ], chemical reactivity [ Hutchison et al. Angew. Chem., Int. Ed. 2012 , 51 , 1592 - 1596 ], ultrafast energy relaxation [ Salomon et al. Angew. Chem., Int. Ed. 2009 , 48 , 8748 - 8751 ; Gomez et al. J. Phys. Chem. B 2013 , 117 , 4340 - 4346 ], and electrical conductivity [ Orgiu et al. Nat. Mater. 2015 , 14 , 1123 - 1129 ] of matter differ significantly to those of the same material in the absence of strong interactions with the electromagnetic fields. Here we show that strong light-matter coupling between confined photons on a semiconductor waveguide and localized plasmon resonances on metal nanowires modifies the efficiency of the photoinduced charge-transfer rate of plasmonic derived (hot) electrons into accepting states in the semiconductor material. Ultrafast spectroscopy measurements reveal a strong correlation between the amplitude of the transient signals, attributed to electrons residing in the semiconductor and the hybridization of waveguide and plasmon excitations.

  2. El «Stabat Mater» glosado y traducido por sor María Gertrudis de la Cruz Hore a fines del siglo XVII

    Directory of Open Access Journals (Sweden)

    Morand, Frédérique

    2006-12-01

    Full Text Available The essay gives us new information about the most famous Gertrudis Hore’s creation, profess in the Concepcionist convent of Santa María in Cádiz, and her several editions. For the first time, we find out the fraud literary and copy of this shrewd poetess, however, at the same time, a really interesting melting between prose, poem and holy music on tightening liturgical period normally distant. In this writing, typical of Virgin literature, a continually using of feminine references do innovation form’s to this text.El artículo da a conocer esta olvidada creación y sus distintas ediciones, el mayor éxito literario de María Gertrudis Hore, religiosa Concepcionista Calzada en Cádiz. Se descubre, por vez primera, la superchería de la astuta erudita, a la vez que la interesante fusión literaria realizada entre prosa, verso y música sacra al estrechar hábilmente dos tiempos litúrgicos habitualmente distantes. En este escrito propiamente inmaculista, el uso continuo del referente femenino destaca por su novedad.

  3. Review of corrosion behavior of ceramic heat exchanger materals: Corrosion characteristics of silicon carbide and silicon nitride. Final report, September 11, 1992--March 11, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Munro, R.G.; Dapkunas, S.J.

    1993-09-01

    The present work is a review of the substantial effort that has been made to measure and understand the effects of corrosion with respect to the properties, performance, and durability of various forms of silicon carbide and silicon nitride. The review encompasses corrosion in diverse environments, usually at temperatures of 1000C or higher. The environments include dry and moist oxygen, mixtures of hot gaseous vapors, molten salts, molten metals, and complex environments pertaining to coal ashes and slags.

  4. Sindicatos Políticos y Economía (1972-1986) San José: Editorial Alma Mater, 1987. (Elisa Donato y Manuel Rojas)

    OpenAIRE

    Botey, Ana M

    2012-01-01

    Introducción Sindicatos, política y economía (1972-1986) es un interesante libro sobre la situación del movimiento sindical costarricense y sus perspectivas futuras. Se divide en siete capítulos: el movimiento sindical después de 1978,  el nivel de vida, características estructurales del movimiento sindical en el periodo sindical 1972-1984,  la actividad del movimiento sindical en el periodo (1972-1984),  el estado y el sindicalismo, Sindicatos, empresarios y sacerdotes. El libro muestra un e...

  5. Celulares: a emergência de um novo tipo de controle materno Cell phones: the emergence of a new king of materal control

    Directory of Open Access Journals (Sweden)

    Ana Maria Nicolaci-da-Costa

    2006-12-01

    Full Text Available Em uma pesquisa exploratória sobre o uso de celulares por jovens das camadas médias cariocas, entre 18 e 25 de idade, foi constatado que eles reclamavam muito que suas mães os controlavam ininterruptamente por meio de seus celulares. Para averiguar mais detalhadamente o que acontece entre mães e filhos dessa faixa etária, foi realizada uma segunda pesquisa. Nesta, foram entrevistadas 20 mães, também pertencentes às camadas médias cariocas, cujos filhos tinham perfil análogo ao dos jovens da primeira pesquisa. Para todas, a principal função dos celulares é abertamente a de controlar os filhos. Elas mostraram, no entanto, saber que há uma diferença entre o controle que vigorava quando eram jovens e aquele ao qual hoje submetem os filhos. Teorias contemporâneas sobre controle e vigilância de fato argumentam que houve uma substituição do controle normativo e coercitivo da modernidade pelo "ter conhecimento" do que se passa, característico da Era da Informação.An exploratory research on the use of cell phones by middle-class youngsters, ages 18 to 25, residing in Rio de Janeiro, revealed that they complained a great deal that their mothers controlled them unrelentingly by means of cell phones. To take a deeper look into what happens between mothers and children in this age group, a second investigation was carried out. Twenty middle-class mothers were interviewed, whose children's profile were analogous to that of the youngsters in the previous research. For all of the mothers, the main benefit of cell phones is to control their children. Nevertheless, they demonstrated to know that there's a difference between the control that they submit their children to from that that prevailed when they themselves were young. Contemporary control and surveillance theories, in fact, argue that the normative and coercive control of modernity has been replaced by "having knowledge" of what goes on, which is characteristic of the Information Era.

  6. Chinese herbal medicine combined with nucleotide analogues for compensated HBV-related cirrhosis: a systematic review of randomized controlled trials

    Directory of Open Access Journals (Sweden)

    Tingting Li

    2015-01-01

    Conclusions: A positive effect was found for FFBJ plus ETV, DHZC plus ADV, and FZHY plus ADV on HA; FZHY plus ADV and FFBJ plus ADV on LN; and FZHY plus ADV on PCIII compared with the effects of NAs used alone.

  7. "La Iglesia, vaso siempre joven del Espíritu de Dios" (Adv. haer. 111,24, 1: Reflexiones sobre el núcleo articulador de la eclesiología de San Ireneo de Lyon

    Directory of Open Access Journals (Sweden)

    Rodrigo Polanco F

    2007-01-01

    Full Text Available El autor presenta el núcleo articulador de la eclesiología de San Ireneo. Frente a la teología gnóstica que negaba la bondad de la creación, y particularmente la corporalidad (carne humana, Ireneo presenta una eclesiología que es consecuencia de su cristología y antropología que valoran tanto al hombre en su corporalidad, como la realidad de la encarnación. En consecuencia, la eclesiología de Ireneo se fundamenta en la bondad de la institución eclesial que es instrumento del Espíritu. El Espíritu de Cristo se hace presente a través de los carismas y de la sucesión apostólica que transmiten la comun1Cación auténtica de Cristo. Es en síntesis una eclesiología del Espíritu encarnado en la estructura de la Iglesia, Espíritu que hace a esta misma Iglesia fiable y fiel al mensaje y persona de JesucristoThe author presents the articulating nucleus of the ecclesiology of St. Irenaeus. In the context of Gnostic theology that denies the goodness of creation, and particularly of human (flesh corporality, Irenaeus presents an ecclesiology that is a consequence of his Christology and his anthropology, which values man as much in his corporality as in the reality of the Incarnation. As a consequence, Irenaeus' ecclesiology is founded upon the goodness of the ecclesial institution that is an instrument of the Spirit. The Spirit of Christ makes itself present through charisms and through the apostol1C succession, that transmit the authentic commun1Cation of Christ. In synthesis, it is an ecclesiology of the Spirit incarnated in the structure of the Church, Spirit that makes this same Church worthy of trust and faithful to the message and person of Jesus Christ

  8. Sujeito da enunciação: singularidade que advém da sintaxe da enunciação Enunciative subject: singularity derived from the enunciative syntax

    Directory of Open Access Journals (Sweden)

    Valdir do Nascimento Flores

    2013-01-01

    Full Text Available Este texto, a partir da leitura da teoria enunciativa criada por Émile Benveniste, desenvolve a noção de sujeito da enunciação ligando-a, metodologicamente, à noção de sintaxe de enunciação como forma de propor uma possibilidade de análise de fatos de língua. O texto ilustra a proposta metodológica em um dado de linguagem infantil.This text, based on the reading of the enunciative theory created by Emile Benveniste, develops the notion of enunciative subject, methodologically linking it to the notion of enunciative syntax in order to propose a possibility for analyzing facts of language. The text illustrates this methodological proposal using data from child language.

  9. Poisson formulas for circular functions on some groups of type H

    Institute of Scientific and Technical Information of China (English)

    KORáNYI; Adam

    2006-01-01

    [1]Gaveau B,Greiner P,Vauthier J.Polyn(o)mes harmoniques et problème de Dirichlet de la boule du groupe de Heisenberg en présence de symétrie radiale.Bull Sc Math,1984,108:337-354[2]Korányi A,Reimann H M.Horizontal normal vectors and conformal capacity of spherical rings in the Heisenberg group.Bull Sc Math,1987,111:3-21[3]Kaplan A.Fundamental solutions for a class of hypoelliptic PDE generated by composition of quadratic forms.Trans AMS,1980,258:147-153[4]Garofalo N,Vassilev D.Symmetry properties of positive solutions of Yamabe-type equations on groups of Heisenberg type.Duke Math J,2001,106:411-448[5]Gaveau B.Principe de moindre action,propagation da la chaleur et estimées sous-elliptiques sur certains groupes nilpotents.Acta Math,1977,139:95-153[6]Cowling M,Dooley A H,Korányi A,et al.H-type groups and Iwasawa decompositions.Adv Math,1991,87:1-41[7]Erdélyi A,et al.Higher transcendental functions.New York:McGraw-Hill,1953[8]Korányi A.Kelvin transforms and harmonic polynomials on the Heisenberg group.J Funct Analysis,1982,49:177-185[9]Garofalo N,Vassilev D.Regularity near the characteristic set in the non-linear Dirichlet problem and conformal geometry of sub-Laplacians on Carnot groups.Math Ann,2000,318:453-516

  10. Shift ergodicity for stationary Markov processes

    Institute of Scientific and Technical Information of China (English)

    CHEN; Jinwen(

    2001-01-01

    [1]Liggett, T. M., Interacting Particle Systems, New York: Springer-Verlag, 1985.[2]Andjel, E. D., Ergodic and mixing properties of equilibrium measures for Markov processes, Trans. of the AMS, 1990, 318:601-614.[3]Franchi, J., Asymptotic windings of ergodic diffusion, Stoch. Processes Appl., 1996, 62: 277-298.[4]Golden, K. , Goldstein, S., Lebowitz, J. L., Nash estimates and the asymptotic behavior of diffusion, Ann. Prob., 1988,16: 1127-1146.[5]Gordin. M. I., Lifsic, B. A. , The central limit theorem for stationary ergodic Markov process, Dokl, Akad. Nauk SSSR,1978, 19: 392-393.[6]Orey, S., Large deviations in ergodic theory, Seminar on Stochastic Processes, 1985, 12: 195-249.[7]Veretenikov, A. Y., On large deviations for ergodic process empirical measures, Adv. Sov. Math., 1992, 12: 125-133.[8]Deuschel, J. D., Stroock, D. W., Large Deviations, San Diego, CA: Academic Press, 1989.[9]Rosenblatt, M., Markov Processes, Structure and Asymptotic Behavior, Berlin: Springer-Verlag, 1971.[10]Liggett, T. M., Stochastic Interacting Systems: Contact, Voter, and Exclusion Processes, Berlin: Springer-Verlag, 1999.[11]Albevrio, S., Kondratiev, Y. G., Rockner, M., Ergodicity of L2-semigroups and extremality of Gibbs states, J. Funct.Anal. , 1997, 144: 293-423.[12]Liverani, C. , Olla, S. , Ergodicity in infinite Hamiltonian systems with conservative noise, Probab. Th. Rel. Fields, 1996,106: 401-445.[13]Varadhan, S. P. S., Large Deviations and Applications, Philadelphia: SIAM, 1984.[14]Chen, J. W. , A variational principle for Markov processes, J. Stat. Phys. , 1999, 96: 1359-1364.

  11. Colossal dielectric constant in high entropy oxides

    Energy Technology Data Exchange (ETDEWEB)

    Berardan, David; Franger, Sylvain; Dragoe, Diana; Meena, Arun Kumar; Dragoe, Nita [ICMMO (UMR 8182 CNRS), Universite Paris-Sud, Universite Paris-Saclay, 91405, Orsay (France)

    2016-04-15

    Entropic contributions to the stability of solids are very well understood and the mixing entropy has been used for forming various solids, for instance such as inverse spinels, see Nawrotsky et al., J. Inorg. Nucl. Chem. 29, 2701 (1967) [1]. A particular development was related to high entropy alloys by Yeh et al., Adv. Eng. Mater. 6, 299 (2004) [2] and Cantor et al., Mater. Sci. Eng. A 375-377, 213 (2004) [3] (for recent reviews see Zhang et al., Prog. Mater. Sci. 61, 1 (2014) [4] and Tsai et al., Mater. Res. Lett. 2, 107 (2014) [5]) in which the configurational disorder is responsible for forming simple solid solutions and which are thoroughly studied for various applications especially due to their mechanical properties, e.g. Gludovatz et al., Science 345, 1153 (2014) [6] and Lu et al., Sci. Rep. 4, 6200 (2014) [7], but also electrical properties, Kozelj et al., Phys. Rev. Lett. 113, 107001 (2014) [8], hydrogen storage, Kao et al., Int. J. Hydrogen Energy 35, 9046 (2010) [9], magnetic properties, Zhang et al., Sci. Rep. 3, 1455 (2013) [10]. Many unexplored compositions and properties still remain for this class of materials due to their large phase space. In a recent report it has been shown that the configurational disorder can be used for stabilizing simple solid solutions of oxides, which should normally not form solid solutions, see Rost et al., Nature Commun. 6, 8485 (2015) [11] these new materials were called ''entropy-stabilized oxides''. In this pioneering report, it was shown that mixing five equimolar binary oxides yielded, after heating at high temperature and quenching, an unexpected rock salt structure compound with statistical distribution of the cations in a face centered cubic lattice. Following this seminal study, we show here that these high entropy oxides (named HEOx hereafter) can be substituted by aliovalent elements with a charge compensation mechanism. This possibility largely increases the potential development of new

  12. Drug: D01421 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available purate sodium; Paraaminohippurate (TN) C9H9N2O3. Na 216.0511 216.1691 D01421.gif Diagnostic aid [renal funct...ly for therapeutic purpose 72 Intracorporeal diagnostic agents 722 Various function testing reagents 7225 Diagnostic

  13. Plasmon resonant gold-coated liposomes for spectrally coded content release

    Science.gov (United States)

    Leung, Sarah J.; Troutman, Timothy S.; Romanowski, Marek

    2009-02-01

    We have recently introduced liposome-supported plasmon resonant gold nanoshells (Troutman et al., Adv. Mater. 2008, 20, 2604-2608). These plasmon resonant gold-coated liposomes are degradable into components of a size compatible with renal clearance, potentially enabling their use as multifunctional agents in applications in nanomedicine, including imaging, diagnostics, therapy, and drug delivery. The present research demonstrates that laser illumination at the wavelength matching the plasmon resonance band of a gold-coated liposome leads to the rapid release of encapsulated substances, which can include therapeutic and diagnostic agents. Leakage of encapsulated contents is monitored through the release of self-quenched fluorescein, which provides an increase in fluorescence emission upon release. Moreover, the resonant peak of these gold-coated liposomes is spectrally tunable in the near infrared range by varying the concentration of gold deposited on the surface of liposomes. Varying the plasmon resonant wavelengths of gold-coated liposomes can provide a method for spectrally-coding their light-mediated content release, so that the release event is initiated by the specific wavelength of light used to illuminate the liposomes. The development of spectrally-coded release can find applications in controlled delivery of multiple agents to support complex diagnostic tests and therapeutic interventions.

  14. Effect of functionalization on the electronic and atomic properties of layered MXenes

    Science.gov (United States)

    Fredrickson, Kurt; Vojvodic, Aleksandra; Nørskov, Jens

    MXenes (M = Transition Metal, X = C or N) are a promising family of materials that have been recently manufactured from MAX phases. MXenes have already been shown as promising candidates for use in lithium ion batteries, supercapacitors, and fuel cells (1). MXenes consist of M_(x)X_(x-1), two-dimensional sheets weakly bound by van der Waals forces. However, due to the selective removal of the A ion to manufacture MXenes, they are highly reactive, with a wide variety of possible functional groups. Previous studies have shown that the electronic properties of MXene single sheets are highly dependent on their functionalization, but so far there are few studies on the effect of functionalization of the bulk phase of MXene, which consists of many layers of MXenes bound together. In this talk, we will illustrate the effect of functionalization of bulk MXenes by H, H2, OH, and O for Mo2C and Ti2C. We will also show the effect of applied potential on the functionalization of Mo2C and Ti2C. Finally, we will compare our results with experimental measurements. (1) M. Naguib, V.D. Mochalin, M.W. Barsoum and Y. Gogotsi, Adv. Mater. 26, 992 (2014).

  15. Structural stability study of protein monolayers in air

    Science.gov (United States)

    Pompa, P. P.; Biasco, A.; Cingolani, R.; Rinaldi, R.; Verbeet, M. Ph.; Canters, G. W.

    2004-03-01

    The assessment of the folding and of the structural stability of a protein in air, upon immobilization in the solid state, represents a critical point from both a fundamental point of view and for the development of solid state nanobioelectronics. The recent demonstrations by Rinaldi et al. [R. Rinaldi et al., Adv. Mater. 14, 1453 (2002); Appl. Phys. Lett. 82, 472 (2003); Ann. (N.Y.) Acad. Sci. 1006, 187 (2003)] of protein-based solid state devices and transistors working in air have raised an intriguing question about the behavior of a biomolecule under nonphysiological conditions. The operation principle of the realized devices is based on the physiological electron transfer function of the metalloprotein azurin. This means that azurin should retain its shape and functionality also in the solid state when utilized in air and at room temperature. In this Brief Report, we prove this claim by analyzing the conformational state of the azurin monolayers developed for such devices by means of intrinsic fluorescence spectroscopy. We show that the immobilization of azurins in the solid state under nonliquid conditions, by means of a specific chemisorption process, does not necessarily lead to protein denaturation. This result is of great importance because it opens up interesting perspectives for the development of solid state hybrid nanodevices for electronic applications requiring nonliquid environments.

  16. Electroactive-Zone Extension in Flow-Battery Stacks

    Energy Technology Data Exchange (ETDEWEB)

    Smith, KC; Brunini, VE; Dong, YJ; Chiang, YM; Carter, WC

    2014-11-20

    Flowable suspensions that conduct both electrons and ions can enable the use of energy-dense electroactive species in flow batteries [M. Duduta et al., Adv. Energy Mater., 1, 511 (2011); Z. Li et al., Phys. Chem. Chem. Phys., 15, 15,833 (2013); F. Fan et al., Nano Lett., 14, 2210 (2014)]. In comparison with conventional flow batteries where electrochemical reactions are confined to a fixed current-collector region, electronically conductive flow electrodes permit electrochemical reactions to extend outside of the physical confines of the stack. We have measured and modeled how mixed-conduction enables an electroactive zone (EAZ, in which electrochemical reactions occur) that is of greater spatial extent than current collectors, the extension being termed side zone, SZ. Electrochemical reactions in SZs can reduce coulombic and energetic efficiency. Here we show that for realistic suspension properties and operating conditions, the added inefficiency is small in practice, and can be further mitigated by using appropriate operating conditions and/or materials choices. For the specific example of a non-aqueous Li4Ti5O12 suspension, we show that EAZ extension contributes less than 1% additional efficiency loss at C/10 rates for current collectors greater than 20 mm long. (C) 2014 Elsevier Ltd. All rights reserved.

  17. Ideal strength and phonon instability in single-layer MoS2

    Science.gov (United States)

    Li, Tianshu

    2012-06-01

    Ideal tensile stress strain relations for single-layer MoS2 are investigated based on first-principle calculation, for biaxial tension and uniaxial tension along zigzag and armchair directions. The predicted ideal tensile strengths and elastic moduli are in excellent agreement with the very recent experimental measurements of Bertolazzi [ACS Nano1936-085110.1021/nn203879f 5, 9703 (2011)] and Castellanos-Gomez [Adv. Mater.ADVMEW0935-964810.1002/adma.201103965 24, 772 (2012)]. It is identified that the tensile strength of single-layer MoS2 are dictated by out-of-plane soft-mode phonon instability under biaxial tension and uniaxial tension along the armchair direction. This failure mechanism, different from that of the truly two-dimensional material graphene, is attributed to the out-of-plane atomic relaxation upon tensile strain. Investigation of the electronic structures of single-layer MoS2 under tensile strain shows the material becomes an indirect semiconductor at small tensile strain (<2%) and turns into metallic before reaching the ideal tensile strength.

  18. Molecular structure of the discotic liquid crystalline phase of hexa-peri-hexabenzocoronene/oligothiophene hybrid and their charge transport properties

    Energy Technology Data Exchange (ETDEWEB)

    Bag, Saientan; Maingi, Vishal; Maiti, Prabal K., E-mail: maiti@physics.iisc.ernet.in [Department of Physics, Center for Condensed Matter Theory, Indian Institute of Science, Bangalore 560012 (India); Yelk, Joe; Glaser, Matthew A.; Clark, Noel A. [Department of Physics, University of Colorado, Boulder, Colorado 80309 (United States); Walba, David M. [Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309 (United States)

    2015-10-14

    Using atomistic molecular dynamics simulation, we study the discotic columnar liquid crystalline (LC) phases formed by a new organic compound having hexa-peri-Hexabenzocoronene (HBC) core with six pendant oligothiophene units recently synthesized by Nan Hu et al. [Adv. Mater. 26, 2066 (2014)]. This HBC core based LC phase was shown to have electric field responsive behavior and has important applications in organic electronics. Our simulation results confirm the hexagonal arrangement of columnar LC phase with a lattice spacing consistent with that obtained from small angle X-ray diffraction data. We have also calculated various positional and orientational correlation functions to characterize the ordering of the molecules in the columnar arrangement. The molecules in a column are arranged with an average twist of 25° having an average inter-molecular separation of ∼5 Å. Interestingly, we find an overall tilt angle of 43° between the columnar axis and HBC core. We also simulate the charge transport through this columnar phase and report the numerical value of charge carrier mobility for this liquid crystal phase. The charge carrier mobility is strongly influenced by the twist angle and average spacing of the molecules in the column.

  19. Polymer-silicon nanosheet composites: bridging the way to optoelectronic applications

    Science.gov (United States)

    Lyuleeva, Alina; Helbich, Tobias; Rieger, Bernhard; Lugli, Paolo

    2017-04-01

    The fabrication of electronic devices from sensitive, functional, two-dimensional (2D) nanomaterials with anisotropic structural properties has attracted much attention. Many theoretical and experimental studies have been performed; however, such materials have not been used in applications. In this context, the focus has shifted toward the study and synthesis of new materials. Freestanding hydrogen-terminated silicon nanosheets (SiNSs) are a new class of material with outstanding (opto)electronic properties (e.g. photoluminescence at approximately 510 nm) (Nakano 2014 J. Ceram. Soc. Japan 122 748). SiNSs are promising candidates for use in nanoelectronic devices and flexible electronics. Additional reasons for interest in such nanomaterials are their structural anisotropy and the fact that they are made from silicon. Here, we present examples for the application of functionalized SiNS-based composites as active materials for photonic sensors. The implementation of SiNSs in a covalent nanocomposite not only improves their stability but also facilitates subsequent device fabrication. Thus, SiNSs can be used in a straightforward setup preparation procedure. We show that the modification of novel Si-based 2D nanosheets with selected organic components not only opens a new field of photosensitive applications but also improves the processability of these nanosheets (Niu et al 2014 Sci. Rep. 4 4810, Chimene et al 2015 Adv. Mater. 27 7261).

  20. Impact of structural heterogeneity in solar absorber layers (Conference Presentation)

    Science.gov (United States)

    Toney, Michael

    2016-09-01

    Impact of structural heterogeneity in solar absorber layers Michael F Toney SLAC National Accelerator Laboratory Structural and morphological heterogeneity is common in thin film and emerging solar cell absorber layers, including organic photovoltaic bulk heterojunctions (OPV BHJs), hybrid organic-inorganic perovskites (HOIP), and Cu2ZnSn(S,Se)4 (CZTSSe), and has a significant impact on the (opto)electronic heterogeneity and hence absorber properties. In this talk I will use X-ray based methods, including scattering and spectroscopies, to characterize and quantify the heterogeneity in OPV BHJs and HOIP absorber layers. The BHJ films are blends of the small molecule X2 and [6,6]-phenyl C71 butyric acid methyl ester (PC71BM) where it has been established that there are three distinct region of the films - pure PC71BM, pure X2 and intimately mixed X2:PC71BM. This talk will show how the absolute concentration of the mixed phase can be used to explain the large PC71BM:X2 composition range where good performance is observed [1]. The talk will also show that spin cast CH3NH3PbI3 films consistent of both crystalline and amorphous regions, which can explain previous heterogeneity in the PL imaging [2]. [1] Huang et al., Adv. Energy Mater. 4, 1301886 (2014). [2] deQuilettes et al., Science 348, 683 (2015).

  1. Vacuum-assisted fluid flow in microchannels to pattern substrates and cells.

    Science.gov (United States)

    Shrirao, Anil B; Kung, Frank H; Yip, Derek; Cho, Cheul H; Townes-Anderson, Ellen

    2014-09-01

    Substrate and cell patterning are widely used techniques in cell biology to study cell-to-cell and cell-substrate interactions. Conventional patterning techniques work well only with simple shapes, small areas and selected bio-materials. This paper describes a method to distribute cell suspensions as well as substrate solutions into complex, long, closed (dead-end) polydimethylsiloxane (PDMS) microchannels using negative pressure. Our method builds upon a previous vacuum-assisted method used for micromolding (Jeon et al 1999 Adv. Mater 11 946) and successfully patterned collagen-I, fibronectin and Sal-1 substrates on glass and polystyrene surfaces, filling microchannels with lengths up to 120 mm and covering areas up to 13 × 10 mm(2). Vacuum-patterned substrates were subsequently used to culture mammalian PC12 and fibroblast cells and amphibian neurons. Cells were also patterned directly by injecting cell suspensions into microchannels using vacuum. Fibroblast and neuronal cells patterned using vacuum showed normal growth and minimal cell death indicating no adverse effects of vacuum on cells. Our method fills reversibly sealed PDMS microchannels. This enables the user to remove the PDMS microchannel cast and access the patterned biomaterial or cells for further experimental purposes. Overall, this is a straightforward technique that has broad applicability for cell biology.

  2. The Application of Artificial Dura Mater to Hemicraniectomy in Patients with Severe Traumatic Brain Injury%人工硬脑膜在去大骨瓣减压术治疗重症颅脑损伤中的应用

    Institute of Scientific and Technical Information of China (English)

    刘涛; 白朝鲁; 梅小波

    2013-01-01

    Objective:To explore the application of large trauma and artificial dural in traumatic brain injury surgery.Method:43 patients with artificial dural in traumatic brain injury surgery were analysed retrospectively,from January 2010 to June 2013.Result:1 patient died of acute high intracranial pressure, more than 42 cases of survival.Evaluation of 1 to six months after GOS:7 cases(16.2%) were cured,mild disability in 12 cases(27.9%),moderate disability in 15 cases(34.8%),severe disability in 5 cases(11.6%),3 cases(7%) of vegetative state,1 case(2.3%) was death.The 40 survivors were followed up,no obvious adverse reaction.Conclusion:Artificial dural repairingcom is safe and effective in large trauma brain injury surgery,It is worthy of clinical application.%目的:探讨大骨瓣结合人工硬脑膜修补术治疗重症颅脑损伤的临床效果。方法:回顾性分析本院自2010年1月-2013年6月收治的43例重症颅脑损伤患者的临床资料,总结手术经验,应用GOS预后评估法对患者术后1个月至半年效果进行评价。结果:1例患者因急性高颅压而死亡,余42例存活。术后1个月至半年内GOS评估:痊愈7例(16.2%),轻残12例(27.9%),中残15例(34.8%),重残5例(11.6%),植物状态3例(7.0%),死亡1例(2.3%)。其中40例存活者得到长期随访,无明显不良反应。结论:大骨瓣减压结合人工硬脑膜修补术治疗重症颅脑损伤疗效可靠,值得临床推广应用。

  3. Poro-elastic modeling of Syringomyelia - a systematic study of the effects of pia mater, central canal, median fissure, white and gray matter on pressure wave propagation and fluid movement within the cervical spinal cord.

    Science.gov (United States)

    Støverud, Karen H; Alnæs, Martin; Langtangen, Hans Petter; Haughton, Victor; Mardal, Kent-André

    2016-01-01

    Syringomyelia, fluid-filled cavities within the spinal cord, occurs frequently in association with a Chiari I malformation and produces some of its most severe neurological symptoms. The exact mechanism causing syringomyelia remains unknown. Since syringomyelia occurs frequently in association with obstructed cerebrospinal fluid (CSF) flow, it has been hypothesized that syrinx formation is mechanically driven. In this study we model the spinal cord tissue either as a poro-elastic medium or as a solid linear elastic medium, and simulate the propagation of pressure waves through an anatomically plausible 3D geometry, with boundary conditions based on in vivo CSF pressure measurements. Then various anatomic and tissue properties are modified, resulting in a total of 11 variations of the model that are compared. The results show that an open segment of the central canal and a stiff pia (relative to the cord) both increase the radial pressure gradients and enhance interstitial fluid flow in the central canal. The anterior median fissure, anisotropic permeability of the white matter, and Poisson ratio play minor roles.

  4. THE EFFECTS OF NF-KB ON ICAM-1 PROTEIN EXPRESSIONS OF RAT DURA MATER WITH MIGRAINE%NF-κB上调偏头痛大鼠脑膜ICAM-1蛋白表达

    Institute of Scientific and Technical Information of China (English)

    何秋; 王怀良; 章新华; 陈磊

    2007-01-01

    目的:探讨核转录因子-κB(nuclear factor-kappa B,NF-κB)在偏头痛脑膜炎症反应中的作用及细胞间黏附分子-1(intercellular adhesion molecules-1,ICAM-1)表达的调控机制.方法采用静脉注射(iv)硝酸甘油(glyceryl trinitrate,GTN)法建立大鼠偏头痛模型,分为对照组、模型组、溶剂对照组、吡咯烷二硫氨基甲酸(pyrrolidine dithiocarbamate,PDTC)组.各组分别包括0.9%生理盐水或GTN iv后1.5,4h两个实验小组.应用Western印迹法分别观察PDTC对GTN iv后1.5h大鼠脑膜NF-κB蛋白表达水平与GTN iv后4h ICAM-1蛋白表达水平的影响.结果:PDTC 50,100,200 mg.kg-1各剂量组GTN iv后1.5h大鼠脑膜NF-κB蛋白表达量较模型组分别降低30%(P<0.05)、52%(P<0.01)和65%(P<0.01),呈剂量依赖性;PDTC 50,100,200 mg.kg-1各剂量组GTN iv后4h大鼠脑膜ICAM-1蛋白表达量较模型组分别降低36%(P<0.05)、71%(P<0.01)和51%(P<0.01),无剂量依赖关系.结论:NF-κB参与偏头痛时脑膜ICAM-1的蛋白合成调控,在偏头痛的脑膜炎症机制中起着重要作用.

  5. Corrigendum to "Preliminary assessment of accident-tolerant fuels on LWR performance during normal operation and under DB and BDB accident conditions" [J. Nucl. Mater. 448 (2014) 520-533

    Science.gov (United States)

    Ott, L. J.; Robb, K. R.; Wang, D.

    2015-06-01

    In Section 5.2, certain material properties for "FeCrAl oxide" were not modeled based on "stainless steel oxide" as indicated in the text. Instead, the "FeCrAl oxide" material properties were modeled using the default properties in MELCOR for "zirconium oxide". The properties affected are the FeCrAl oxide density, specific heat, enthalpy, thermal conductivity, melting point, and latent heat of fusion. Table 5.1 and Figs. 5.1a-d from Section 5.2 have been corrected below. As discussed below, the overall conclusions of the paper remain unchanged.

  6. Comment on "High-temperature soft magnetic properties of antiperovskite nitrides ZnNFe3 and AlNFe3" by Yankun Fu, Shuai Lin, and Bosen Wang, J. Magn. Magn. Mater. 378 (2015) 54-58

    Science.gov (United States)

    Scholz, T.; Leineweber, A.; Dronskowski, R.

    2016-10-01

    The authors of the aforementioned manuscript have recently claimed the synthesis of the ternary nitrides ZnNFe3 (=ZnFe3N) and AlNFe3 (=AlFe3N), ordered substituted variants of the binary phase γ'-Fe4N [1]. While soft ferromagnets of such kind are presently attracting lots of attention, their history dates back for more than half a century. In particular, Al-substituted γ'-Fe4N has already been mentioned in 1961 [2], and the existence of AlFe3N has also been claimed in 2009 [3] from a two-step ammonolysis reaction combining a high-temperature sintering step and a low-temperature nitriding reaction [4]. Nonetheless, one of us had to withdraw the latter claim after finding out, by means of scanning-electron microscopy and elemental mapping, that all samples of "AlFe3N" consisted of an intimate solid mixture of γ'-Fe4N and amorphous Al2O3[5]. From what follows, we have strong reasons to believe that the authors of Ref. [1] overlooked our findings [5] and also did not synthesize ZnFe3N and AlFe3N.

  7. InterProScan Result: FS765138 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 05804 Fatty acid desaturase, type 1 Biological Process: lipid metabolic process (GO:0006629)|Molecular Funct...ion: oxidoreductase activity (GO:0016491)|Biological Process: oxidation reduction (GO:0055114) ...

  8. Treatment-related changes in functional connectivity in brain tumor patients : a magnetoencephalography study

    NARCIS (Netherlands)

    Douw, Linda; Baayen, Hans; Bosma, Ingeborg; Klein, Martin; Vandertop, Peter; Heimans, Jan; Stam, Kees; de Munck, Jan; Reijneveld, Jaap

    2008-01-01

    Widespread disturbances in resting state functional connectivity between remote brain areas have been demonstrated in patients with brain tumors. Functional connectivity has been associated with neurocognitive deficits in these patients. Thus far, it is unknown how (surgical) treatment affects funct

  9. The Adsorption of Argon and Oxygen on Silver Mordenite

    Science.gov (United States)

    1990-01-01

    O.ODO ESSB =O.ODO DO I=1,NA PYRT=XA( I) CALL FUNCT (PYRT, XKA, XRA, FUN) ESSA=ESSA+(YA( I)-FUN)**2 ENDDO DO I-1,NB PYRT=XB( I) CALL FUNCT(PYRT,XKB,XRB...FUN) ESSB = ESSB +(YB( I)-FUN)**2 101 ENDDO SIGA=DSQRT(ESSA/(DFLOAT(NA-2))) SIGB=DSQRT( ESSB /(DFLOAT(NB-2))) 99 FORMAT(’ ’) 100 FORMAT(’ The Langmuir

  10. NEUROLOGICAL DISORDER

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    13.1 Neuroanatomy, Neurophysiology and Neuropathology2007131 Study on decision-making alternation after bilateral nucleus accumbens ablation in drug addicts. HOU Yuan-zheng(侯远征),et al. Dept Neurosurg, Instit Funct Neurosurg, Instit Funct Cerebullar Dis, Tangdu Hosp, 4th Milit Med Univ, Xi′an 710038. Chin J Nerv Ment Dis 2006;32(6)494-497. Objective To explore decision-making alternation after bilateral nucleus accumbens ablation in drug addicts and analyse the reason.

  11. Geodesic flows on path spaces

    Institute of Scientific and Technical Information of China (English)

    XIANG; Kainan

    2001-01-01

    [1] Cruzeiro, A. B., Malliavin, P., Renormalized differential geometry on path spaces: Structural equation, curvature, J. Funct. Anal., 1996, 139: 119-181.[2] Stroock, D. W., Some thoughts about Riemannian structures on path spaces, preprint, 1996.[3] Driver, B., A Cameron-Martin type quasi-invariance theorem for Brownian motion on a compact manifold, J. Funct. Anal., 1992, 109: 272-376.[4] Enchev, O., Stroock, D. W., Towards a Riemannian geometry on the path space over a Riemannian manifold, J. Funct. Anal., 1995, 134: 392-416.[5] Hsu, E., Quasi-invariance of the Wiener measure on the path space over a compact Riemannian manifold, J. Funct. Anal., 1995, 134: 417-450.[6] Lyons, T. J., Qian, Z. M., A class of vector fields on path space, J.Funct. Anal., 1997, 145: 205-223.[7] Li, X. D., Existence and uniqueness of geodesics on path spaces, J. Funct. Anal., to be published.[8] Driver, B., Towards calculus and geometry on path spaces, in Proc. Symp. Pure and Appl. Math. 57 (ed. Cranston, M., Pinsky, M.), Cornell: AMS, 1993, 1995.

  12. Central limit theorem for integrated square error of kernel estimators of spherical density

    Institute of Scientific and Technical Information of China (English)

    ZHAO; Lincheng

    2001-01-01

    [1] Cruzeiro, A. B., Malliavin, P., Renormalized differential geometry on path spaces: Structural equation, curvature, J. Funct. Anal., 1996, 139: 119-181.[2] Stroock, D. W., Some thoughts about Riemannian structures on path spaces, preprint, 1996.[3] Driver, B., A Cameron-Martin type quasi-invariance theorem for Brownian motion on a compact manifold, J. Funct. Anal., 1992, 109: 272-376.[4] Enchev, O., Stroock, D. W., Towards a Riemannian geometry on the path space over a Riemannian manifold, J. Funct. Anal., 1995, 134: 392-416.[5] Hsu, E., Quasi-invariance of the Wiener measure on the path space over a compact Riemannian manifold, J. Funct. Anal., 1995, 134: 417-450.[6] Lyons, T. J., Qian, Z. M., A class of vector fields on path space, J.Funct. Anal., 1997, 145: 205-223.[7] Li, X. D., Existence and uniqueness of geodesics on path spaces, J. Funct. Anal., to be published.[8] Driver, B., Towards calculus and geometry on path spaces, in Proc. Symp. Pure and Appl. Math. 57 (ed. Cranston, M., Pinsky, M.), Cornell: AMS, 1993, 1995.

  13. A elasticidade do ligamento colateral medial da articulação do cotovelo de cão não advém de elastina The elasticity of the medial collateral ligament of the canine elbow joint does not come from elastin

    Directory of Open Access Journals (Sweden)

    Paloma Souza Costa

    2008-09-01

    Full Text Available A literatura relata que ligamentos consistem de tecido conjuntivo denso, composto por água, colágeno tipos I e III, diversas proteoglicanas, pouca elastina e várias outras substâncias. Além disso, os ligamentos, quando testados in vitro com tensão longitudinal e unidirecional, apresentam um comportamento mecânico não-linear, ou seja, as fibras colágenas são alongadas aos poucos, perdendo seu padrão ondulado, até que todas estejam no limite máximo de tração e iniciem o rompimento. Portanto, no presente estudo avaliou-se a presença de fibras elásticas (elastina no ligamento colateral medial do cotovelo de cães adultos para ponderar se a elasticidade do referido ligamento deve-se à presença de fibras elásticas ou às propriedades elásticas do colágeno ou à combinação de ambas. Foram utilizadas quatro articulações, de machos e fêmeas em igual proporção, das quais foram adquiridas as amostras das porções médias dos ligamentos colaterais mediais para a rotina histológica. Os cortes foram corados pela técnica de Weigert, e não foi observada a presença de fibras elásticas, detectável por esta técnica à microscopia de luz. Concluiu-se que a elasticidade do ligamento colateral medial do cotovelo de cão deve-se, principalmente, ao padrão ondulado das fibras colágenas, devido à quantidade ínfima ou até à inexistência de fibras elásticas nesta estrutura.The literature reports that ligaments consist of connective tissue, composed by water, Type I and III collagen, several proteoglycans, some elastin and other substances. Ligaments tested in vitro with longitudinal and unidirectional tension exhibit non-linear mechanical behavior; the collagen fibers are stretched little by little, losing their undulating pattern, until reaching the maximum limit of traction and failure begins. The aim of the present study was to assess the presence of elastin in the medial collateral ligament of the elbow in adult dogs to determine whether the stretching of this ligament is due to the presence of elastic fibers, the elastic property of the collagen or the combination of both. Four joints were used from males and females in equal proportion, taking the medial collateral ligaments for the histological examination. To detect the presence of elastic fibers, sections were stained using the Weigert method. However, light microscopy revealed no elastic fibers. It was concluded that the elasticity of the canine elbow medial collateral ligament is mainly due to the undulated pattern of the collagen fibers, considering the trace amount or inexistence of elastic fibers in this structure.

  14. Investigation of the pathogenesis of transplacental transmission of Aleutian mink disease parvovirus in experimentally infected mink

    DEFF Research Database (Denmark)

    Broll, S.; Alexandersen, Søren

    1996-01-01

    The transplacental transmission of Aleutian mink disease parvovirus (ADV) was studied in experimental infection of 1-year-old female non-Aleutian mink. The ADV-seronegative female mink were inoculated,vith ADV prior to mating or after the expected implantation of the embryos during pregnancy...

  15. Characteristics of Adenovirus Pneumonia in Korean Military Personnel, 2012-2016.

    Science.gov (United States)

    Yoon, Hee; Jhun, Byung Woo; Kim, Hojoong; Yoo, Hongseok; Park, Sung Bum

    2017-02-01

    Adenovirus (AdV) can cause severe pneumonia in non-immunocompromised host, but limited data exist on the distinctive characteristics of AdV pneumonia in non-immunocompromised patients. We evaluated distinctive clinico-laboratory and radiological characteristics and outcomes of AdV pneumonia (n = 179), compared with non-AdV pneumonia (n = 188) in Korean military personnel between 2012 and 2016. AdV pneumonia patients had a higher rate of consolidation with ground-glass opacity (101/152) in lobar distribution (89/152) on computed tomography (CT) (P pneumonia patients. Bacterial co-infection was identified in 28.5% of AdV pneumonia. Most of the AdV isolates typed (69/72, 95.8%) were AdV-55. Patients with a pneumonia severity index ≥ class III were more commonly observed in AdV pneumonia patients compared with non-AdV pneumonia patients (11.2% vs. 2.1%, P pneumonia patients compared with the non-AdV pneumonia patients (3.8 vs. 2.6 days, P pneumonia patients, one of whom died due to AdV-55. Our data showed that AdV pneumonia in non-immunocompromised patients had distinct characteristics and most of the isolates typed in our study were AdV-55. It is suggested that AdV-55 is an important pathogen of pneumonia in Korean military personnel.

  16. 77 FR 39767 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

    Science.gov (United States)

    2012-07-05

    ... rebate tier depends on an ETP Holder's ADV. Endnote 3 provides that ``ADV'' means, with respect to an ETP... occurred. Endnote 3 further clarifies that ``ADV'' as used with respect to the Exchange's Automatic.... Endnote 5, which is proposed to apply to each of the four rebate tiers in Order Delivery, provides that...

  17. Virus Infection

    Directory of Open Access Journals (Sweden)

    Hiroshi Abe

    2013-01-01

    Full Text Available Of 168 patients with chronic hepatitis B virus (HBV infection-related liver disease, 20 patients who had received 100 mg of lamivudine plus 10 mg/day of adefovir dipivoxil (ADV (ADV group and 124 patients who had received 0.5 mg/day of entecavir or 100 mg/day of lamivudine (non-ADV group for >1 year were enrolled. For comparative analyses, 19 well-matched pairs were obtained from the groups by propensity scores. At the time of enrollment, serum creatinine and phosphate concentrations were similar between the ADV and non-ADV groups; however, urinary phosphate ( and serum bone-specific alkaline phosphatase (BAP ( concentrations were significantly higher in the ADV group than in the non-ADV group. Serum BAP was significantly higher at the time of enrollment than before ADV administration in the ADV group (, although there was no significant change in serum BAP concentration in the non-ADV group. There was a significant positive correlation between the period of ADV therapy and ΔBAP (, . Serum BAP concentration increased before increase in serum creatinine concentration and was useful for early detection of adverse events and for developing adequate measures for continuing ADV for chronic HBV infection-related liver disease.

  18. Cohesive zone model for intergranular slow crack growth in ceramics: influence of the process and the microstructure

    Science.gov (United States)

    Romero de la Osa, M.; Estevez, R.; Olagnon, C.; Chevalier, J.; Tallaron, C.

    2011-10-01

    Ceramic polycrystals are prone to slow crack growth (SCG) which is stress and environmentally assisted, similarly to observations reported for silica glasses. The kinetics of fracture are known to be dependent on the load level, the temperature and the relative humidity. In addition, evidence is available on the influence of the microstructure on the SCG rate with an increase in the crack velocity with decreasing the grain size. Crack propagation takes place beyond a load threshold, which is grain size dependent. We present a cohesive zone model for the intergranular failure process. The methodology accounts for an intrinsic opening that governs the length of the cohesive zone and allows the investigation of grain size effects. A rate and temperature-dependent cohesive model is proposed (Romero de la Osa M, Estevez R et al 2009 J. Mech. Adv. Mater. Struct. 16 623-31) to mimic the reaction-rupture mechanism. The formulation is inspired by Michalske and Freiman's picture (Michalske and Freiman 1983 J. Am. Ceram. Soc. 66 284-8) together with a recent study by Zhu et al (2005 J. Mech. Phys. Solids 53 1597-623) of the reaction-rupture mechanism. The present investigation extends a previous work (Romero de la Osa et al 2009 Int. J. Fracture 158 157-67) in which the problem is formulated. Here, we explore the influence of the microstructure in terms of grain size, their elastic properties and residual thermal stresses originating from the cooling from the sintering temperature down to ambient conditions. Their influence on SCG for static loadings is reported and the predictions compared with experimental trends. We show that the initial stress state is responsible for the grain size dependence reported experimentally for SCG. Furthermore, the account for the initial stresses enables the prediction of a load threshold below which no crack growth is observed: a crack arrest takes place when the crack path meets a region in compression.

  19. Highly active nanocrystalline TiO(2) photoelectrodes.

    Science.gov (United States)

    Paronyan, Tereza M; Kechiantz, A M; Lin, M C

    2008-03-19

    A simple method for the fabrication of highly photoactive nanocrystalline two-layer TiO(2) electrodes for solar cell applications is presented. Diluted titanium acetylacetonate has been used as a precursor for covering SnO(2):F (FTO) films with dense packed TiO(2) nanocrystallites. The nanoporous thick TiO(2) film follows the dense packed thin TiO(2) film as a second layer. For the latter, amorphous TiO(2) nanoparticles have been successfully synthesized by a sol-gel technique in an acidic environment with pHTiO(2) gel of pH 5 was obtained; this pH value is higher than the recently reported value of 3.1 (Park et al 2005 Adv. Mater. 17 2349-53). Highly interconnected, nanoporous, transparent and active TiO(2) films have been fabricated from the pH 5 gel. SEM, AFM and XRD analyses have been carried out for investigation of the crystal structure and the size of nanoparticles as well as the surface morphology of the films. Investigation of the photocurrent-voltage characteristics has shown improvement in cell performance along with the modification of the surface morphology, depending on pH of the TiO(2) gel. Increasing the pH of the gel from 2.1 to 5 enhanced the overall conversion efficiency of the dye-sensitized solar cells by approximately 30%. An energy conversion efficiency of 8.83% has been achieved for the cell (AM1.5, 100  mWcm(-2) simulated sunlight) compared to 6.61% efficiency in the absence of ammonia in the TiO(2) gel.

  20. Defects responsible for abnormal n-type conductivity in Ag-excess doped PbTe thermoelectrics

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Byungki, E-mail: byungkiryu@keri.re.kr; Lee, Jae Ki; Lee, Ji Eun; Joo, Sung-Jae; Kim, Bong-Seo; Min, Bok-Ki; Lee, Hee-Woong; Park, Su-Dong [Thermoelectric Conversion Research Center, Korea Electrotechnology Research Institute (KERI), 642-120 Changwon (Korea, Republic of); Oh, Min-Wook [Department of Advanced Materials Engineering, Hanbat National University, 305-719 Daejeon (Korea, Republic of)

    2015-07-07

    Density functional calculations have been performed to investigate the role of Ag defects in PbTe thermoelectric materials. Ag-defects can be either donor, acceptor, or isovalent neutral defect. When Ag is heavily doped in PbTe, the neutral (Ag-Ag) dimer defect at Pb-site is formed and the environment changes to the Pb-rich/Te-poor condition. Under Pb-rich condition, the ionized Ag-interstitial defect (Ag{sub I}{sup +}) becomes the major donor. The formation energy of Ag{sub I}{sup +} is smaller than other native and Ag-related defects. Also it is found that Ag{sub I}{sup +} is an effective dopant. There is no additional impurity state near the band gap and the conduction band minimum. The charge state of Ag{sub I}{sup +} defect is maintained even when the Fermi level is located above the conduction band minimum. The diffusion constant of Ag{sub I}{sup +} is calculated based on the temperature dependent Fermi level, formation energy, and migration energy. When T > 550 K, the diffusion length of Ag within a few minutes is comparable to the grain size of the polycrystalline PbTe, implying that Ag is dissolved into PbTe and this donor defect is distributed over the whole lattice in Ag-excess doped polycrystalline PbTe. The predicted solubility of Ag{sub I}{sup +} well explains the increased electron carrier concentration and electrical conductivity reported in Ag-excess doped polycrystalline PbTe at T = 450–750 K [Pei et al., Adv. Energy Mater. 1, 291 (2011)]. In addition, we suggest that this abnormal doping behavior is also found for Au-doped PbTe.

  1. Structural modification of Li[Li{sub 0.27}Co{sub 0.20}Mn{sub 0.53}]O{sub 2} by lithium extraction and its electrochemical property as the positive electrode for Li-ion batteries

    Energy Technology Data Exchange (ETDEWEB)

    Kumagai, Naoaki; Kim, Jung-Min; Tsuruta, Syo; Kadoma, Yoshihiro; Ui, Koichi [Department of Frontier Materials and Functional Engineering, Graduate School of Engineering, Iwate University, 4-3-5 Ueda, Morioka, Iwate 020-8551 (Japan)

    2008-06-30

    In our previous report, we have synthesized Li{sub 2}MnO{sub 3}-LiCoO{sub 2} solid solutions and have investigated electrochemical properties [J.-M. Kim, T. Sho, N. Kumagai, Electrochem. Commun. 9 (2007) 103]. These materials have showed a long charge plateau at above 4.5 V during the first charge, which disappears with the subsequent cycles. This phenomenon is usually observed in Li{sub 2}MnO{sub 3} and Li{sub 2}MnO{sub 3}-LiMeO{sub 2} system (Me = Ni{sub 1/2}Mn{sub 1/2} [Z. Lu, D.D. MacNeil, J.R. Dahn, Electrochem. Solid State Lett. 4 (2001) 191], Co [K. Numata, C. Sakaki, S. Yamanaka, Solid State Ionics 117 (1999) 257; Y.J. Park, Y.-S. Hong, X. Wu, M.K. Kim, K.S. Ryu, S.H. Chang, J. Electrochem. Soc. 151 (2004) A720], Fe [M. Tabuchi, A. Nakashima, H. Shigemura, K. Ado, H. Kobayashi, H. Sakaebe, H. Kageyama, T. Nakamura, M. Kohzaki, A. Hirano, R. Kanno, J. Electrochem. Soc. 149 (2002) A509], or Cr [B. Ammundsen, J. Paulsen, Adv. Mater. 13 (2001) 943]). In this study, we investigate the relationship between the first lithium extraction process and the electrochemical property of the synthesized Li[Li{sub 0.27}Co{sub 0.2}Mn{sub 0.53}]O{sub 2} material. The crystal structure and electrochemical performance of the synthesized Li[Li{sub 0.27}Co{sub 0.20}Mn{sub 0.53}]O{sub 2} are modified by the Li{sup +} extraction. (author)

  2. Meninges of the brain (image)

    Science.gov (United States)

    ... by 3 connective tissue layers collectively called the meninges. Consisting of the pia mater (closest to the ... the dura mater (farthest from the CNS), the meninges also support blood vessels and contain cerebrospinal fluid. ...

  3. Meninges of the spine (image)

    Science.gov (United States)

    ... by 3 connective tissue layers collectively called the meninges. Consisting of the pia mater (closest to the ... the dura mater (farthest from the CNS), the meninges also support blood vessels and contain cerebrospinal fluid. ...

  4. Adenovirus as a gene therapy vector for hematopoietic cells.

    Science.gov (United States)

    Marini, F C; Yu, Q; Wickham, T; Kovesdi, I; Andreeff, M

    2000-06-01

    Adenovirus (Adv)-mediated gene transfer has recently gained new attention as a means to deliver genes for hematopoietic stem cell (HSC) or progenitor cell gene therapy. In the past, HSCs have been regarded as poor Adv targets, mainly because they lack the specific Adv receptors required for efficient and productive Adv infection. In addition, the nonintegrating nature of Adv has prevented its application to HSC and bone marrow transduction protocols where long-term expression is required. There is even controversy as to whether Adv can infect hematopoietic cells at all. In fact, the ability of Adv to infect epithelium-based targets and its inability to effectively transfect HSCs have been used in the development of eradication schemes that use Adv to preferentially infect and "purge" tumor cell-contaminating HSC grafts. However, there are data supporting the existence of productive Adv infections into HSCs. Such protocols involve the application of cytokine mixtures, high multiplicities of infection, long incubation periods, and more recently, immunological and genetic modifications to Adv itself to enable it to efficiently transfer genes into HSCs. This is a rapidly growing field, both in terms of techniques and applications. This review examines the two sides of the Adv/CD34 controversy as well as the current developments in this field.

  5. S-phase-dependent cell cycle disturbances caused by Aleutian mink disease parvovirus

    DEFF Research Database (Denmark)

    Oleksiewicz, M.B.; Alexandersen, Søren

    1997-01-01

    We examined replication of the autonomous parovirus Aleutian mink disease parovirus (ADV) in relation to cell cycle progression of permissive Crandell feline kidney (CRFK) cells. Flow cytometric analysis showed that ADV caused a composite, binary pattern of cell cycle arrest. ADV-induced cell cycle...... with subthreshold levels of ADV products through the late S/G(2) block and, consequently, that the binary pattern of ADV-induced cell cycle arrest may be governed merely by viral replication levels within a single S phase. Flow cytometric analysis of propidium iodide fluorescence and bromodeoxyuridine uptake showed...... that population A cells sustained significantly higher levels of DNA replication than population B cells during the ADV-induced cell cycle arrest. Therefore, the type of ADV-induced cell cycle arrest was not trivial and could have implications for subsequent viral replication in the target cell....

  6. Electroluminescent properties of three ternary europium complexes with different phenanthroline derivatives

    Institute of Scientific and Technical Information of China (English)

    BIAN; Zuqiang; GAO; Deqing; GUAN; Min; XIN; Hao; LI; Fuyou

    2004-01-01

    [1]Sun, P. P., Duan, J. P., Shih, H. T. et al., Europium complex as a highly efficient red emitter in electroluminescent devices, Appl.Phys. Lett., 2002, 81: 792-793.[2]Heil, H., Steiger, J., Schmechel, R. et al., Tri(dibenzolymethane)(monophenanthroline) europium(Ⅲ) based red emitting organic light emitting diodes, J. Appl. Phys., 2001, 90: 5357-5362.[3]Liang, C. L., Zhao, D., Hong, Z. R. et al., Improved performance of electroluminescent devices based on an europium complex,Appl. Phys. Lett., 2000, 76: 67-69.[4]Kido, J., Hayase, H., Honggawa, K. et al., Bright red light-emitting organic electroluminescent devices having a europium complex as an emitter, Appl. Phys. Lett., 1994, 65: 2124-2126.[5]Mitsuharu, N., Kazutaka, I., Masanao, E., Efficient red electroluminescence from new europium complex, Chem. Lett., 2001:320-321.[6]Kido, J., Nagai, K., Okamoto, Y., Organic electroluminescem devices using lanthanide complexes, J. Alloys. Compd., 1993, 192:30-33.[7]Wang, J., Wang, R., Yang, J. et al., First oxadiazole-functionalized terbium(Ⅲ) β-diketonate for organic electroluminescence, J. Am.Chem. Soc., 2001, 123: 6179-6180.[8]Capecchi, S., Renault, O., Moon, D. G., High-efficiency organic electroluminescent devices using an organoterbium emitter, Adv.Mater., 2000, 12: 1591-1594.[9]Huang, L., Wang, K. Z., Huang, C. H. et al., Synthetic and electroluminescent properties of two novel europium complexes with benzimidazole derivatives as second ligands, Synth. Met., 2002,128: 241-245.[10]Huang, L., Wang, K. Z., Huang, C. H. et al., Bright red electroluminescent devices using novel second-ligand-contained europium complexes as emitting layers, J. Mater. Chem., 2001, 11: 790-793.[11]Hu, W. P., Matsumura, M., Wang, M. Z. et al., Efficient red electroluminescence from devices having multilayers of an europium complex, Appl. Phys. Lett., Appl. Phys. Lett., 2000, 77: 4271-4273.[12]Yu, G., Liu, Y. Q., Wu, X. et al., Soluble

  7. 国外文献速报

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Gunduz M,Cadirli E.Pb-Sn合金的定向凝固(英).J.Mater.Sci.,2000,35 (15):3837~3848 040113 Nave M D,Dahle A K,John D H St.凝固速度对镁合金共晶晶粒组织的影响(英).Int.J.Cast Met.Res.,2000,13 (1):1~7 040114 Martorano M A,Capoccli J D T.定向凝固青铜铸件枝晶组织的控制(英).Int.J.Cast Met.Res.,2000,13(1): 49~57 040115 Zhang Y L,Li Q,Li Y X.NiAl形状记忆合金的单晶生长(英).Prog.Cryst.Growth Charact.Mater.,2000,4(1-4): 309~314 040116 Cheng T T.TiAl合金中添加B细化晶粒的机理-- 一种可选择的假设(英).Intermatallics,2000,8(1): 29~31 040117 Pao P S,Feng C K,Gill S J.关于7075-T7351合金从腐蚀凹坑开始时的裂纹(英).Scr.Mater.,2000,43(5):391~396 040118 Hilpert M,Wagner L.高强度镁合金AZ80的腐蚀疲劳行为(英).J.Mater.Eng.Perform.,2000,9(4): 402~407 040119 Sasaki G,Fukunaga H,Yoshida M.镁基复合材料的制造工艺及微观组织分析(英).Mater.Jpn.,2000,39(6): 519~525 040120 Kosec B,Bizjak M,Kosec L.两相铜基材料拉伸变形的宏观模拟(英).Metall.2000,69(5):384~386 040121 Machovec C J,Zindel J W,Godlewski L A.Bi-Sr复合变质对319铝合金中Si形态影响的效果分析(英).Mod.Cast.,2000(6):42~44 040122 Maeng D Y,Chun B S,Hong H J.快速凝固挤压Mg-Zn合金的组织和强度(英).Scr.Mater.,2000,43(5):385~389 040123 Kim H G,Kim J Y,Cho Y T.预应变对形状记忆合金弹性的影响分析研究(英).Key Eng.Mater.,2000 (2):1219~1224 040124 Cho W D,Kim I,Kim H J.含Y的Fe3Al的高温氧化(英).J.Mater.Sci.,2000,35 (18): 4695~4703 金属基复合材料 040201 Hirai H,Kitahara A,Tabarn T.定向凝固No-xMo-22Ti-18Si原位(In-Stiu)复合材料的组织和力学性能(日).J.Jpn.Inst.Met.,2000,64(6): 474~480 040202 Korner C,Ottmuller M,Schaff W.碳长纤维增强镁基复合材料(英).Adv.Eng.Mater.,2000,2(6): 327~337 040203 Naplocha K,Samsonowicz Z.AlSi9Mg基Al2O3短纤维增强复合材料(葡).Przegl.Odlew.,2000,50(4):127~130 040204 Lee J C

  8. Evaluation on effects of bone morphoge netic protein2-9 mediated by co-expressing recombinant adenovirus combined with nano-hydroxyapatite/polyamide 66 cage on lumbar interbody fusion of goats%双表达重组腺病毒介导的骨形态发生蛋白2-9复合纳米羟基磷灰石/聚酰胺66融合器用于山羊椎间融合的效果评价

    Institute of Scientific and Technical Information of China (English)

    马金梁; 黄帆; 汪洋; 罗进勇; 邓忠良

    2012-01-01

    目的:比较双表达重组腺病毒介导的骨形态发生蛋白2-9 (Adv-BMP2-9)与单表达Adv-BMP9和Adv-BMP2复合纳米羟基磷灰石/聚酰胺66 (nHA/PA66)融合器用于山羊椎间融合的效果,验证BMP2与BMP9的协同成骨作用.方法:选用40只中国青山羊行L2-3、L3-4和L4-5腰椎间融合术,共融合120个腰椎间隙.每个腰椎间隙植入nHA/PA66融合器复合以下4种腺病毒之一,Adv-BMP9(Adv-BMP9组,n=30)、Adv-BMP2 (Adv-BMP2组,n=30)、Adv-BMP2-9 (Adv-BMP2-9组,n=30)和Adv-GFP (Adv-GFP组,n=30).术后24周处死所有山羊,取出融合节段标本,行影像学评估和生物力学分析.结果:X线检测,术前、术后各组间椎间隙高度(DSH)比较差异无统计学意义(P>0.05);各组标本椎间融合率,Adv-BMP2-9组为70%(21/30),Adv-BMP9组为53%(16/30),Adv-BMP2组为43% (13/30),而Adv-GFP组为30% (9/30).各组椎间CT融合度评分,Adv-hBMP2-9组、Adv-hBMP9组、Adv-hBMP2组和Adv-GFP组依次为52.29±0.72、44.02±0.67、38.83±0.86和28.65±0.47,各组间比较差异均具有统计学意义(P<0.05或P<0.01).生物力学评估,Adv-BMP2-9组融合节段刚度大于Adv-BMP9组(P<0.05);Adv-BMP9组融合节段刚度大于Adv-BMP2组,但差异无统计意义(P>0.05).实验期间各组山羊均未观察到局部或远处感染、发热和异物排斥反应.结论:双表达Adv-BMP2-9复合nHA/PA66融合器对山羊椎间融合效果优于单表达Adv-BMP9或Adv-BMP2,BMP2与BMP9具有协同成骨作用.

  9. Projections of Singular Vectors of Verma Modules over Rank 2 Kac-Moody Lie Algebras

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    Dmitry Fuchs

    2008-08-01

    Full Text Available We prove an explicit formula for a projection of singular vectors in the Verma module over a rank 2 Kac-Moody Lie algebra onto the universal enveloping algebra of the Heisenberg Lie algebra and of sl_2 (Theorem 3. The formula is derived from a more general but less explicit formula due to Feigin, Fuchs and Malikov [Funct. Anal. Appl. 20 (1986, no. 2, 103-113]. In the simpler case of A_1^1 the formula was obtained in [Fuchs D., Funct. Anal. Appl. 23 (1989, no. 2, 154-156].

  10. Boundedness of a class of super singular integral operators and the associated commutators

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    [1]Calderón, A. P., Zygmund, A., On singular integrals, Amer. J. Math., 1956, 78: 89-309.[2]Fefferman, R., A note on singular integrals, Proc. Amer. Math. Soc., 1979, 74(2): 266-270.[3]Duoandikoetxea, J., Rubio de Francia, L. J., Maximal and singular integral operators via Fourier transform estimates, Invent. Math., 1986, 84(3): 541-561.[4]Dan, D. S., Pan, Y. B., Singular integral operators with rough kernel, Amer. J. Math., 1997, 119(4): 799-839.[5]Chen, J. C., Fan, D. S., Ying, Y. M., Certain operators with singular kernels, Canadian J. Math., 2003, 55(3):504-532.[6]Frazier, M., Jawerth, B., Weiss, G., Littlewood-Paley Theory and Study of Function Spaces, AMS-CBMS Regional Conf Ser, Vol. 79, Washington D C: Conf. Board Math. Sci., 1991, 41-49.[7]Coifman, R. R., Rochberg, R., Weiss, G., Factorization theorems for Hardy spaces in several variables, Ann.Math., 1976, 103(3): 611-635.[8]Duoandikoetxea, J., Weighted norm inequalities for homogeneous singular integrals, Trans. Amer. Math. Soc.,1993, 336(2): 869-880.[9]Alvarez, J., Bagby, R., Kurtz, D. et al., Weighted estimates for commutators of linear operators, Studia Math.,1993, 104(2): 195-209.[10]Hu, G., Lp boundedness for the commutator of a homogeneous singular integral operator, Studia Math., 2002,154(1): 13-27.[11]Lu, S., Wu, Q., Yang, D., Boundedness of commutators on Hardy type spaces, Sci. China Ser. A, 2002, 45(8):984-997.[12]Calderón, A. P., Commutators of singular integral operators, Proc. Nat. Acad. Sci. USA, 1965, 53: 1092-1099.[13]Hofmann, S., An off-diagonal T1 theorem and applications, J. Funct. Anal., 1998, 160(2): 581-622.[14]Colzani, L., Taibleson, M., Weiss, G., Maximal estimates for Cesaro and Riesz means on sphere, Indiana Univ.Math. J., 1984, 33(6): 873-889.[15]Stein, E. M., Harmomic Analysis: Real-Variable Methods, Orthogonality and Osillatory Integrals, Princeton,New Jersy: Princeton University Press, 1993.[16

  11. Embedding theorems of Besov and Triebel-Lizorkin spaces on spaces of homogeneous type

    Institute of Scientific and Technical Information of China (English)

    YANG; Dachun(

    2003-01-01

    , Cambridge: Cambridge Univ. Press, 1996.[15]Macias, R. A., Segovia, C., Lipschitz functions on spaces of homogeneous type, Adv. in Math., 1979, 33: 257.[16]Han, Y., Sawyer, E. T., Littlewood-Paley theory on spaces of homogeneous type and classical function spaces,Memoirs Amer. Math. Soc., 1994, 110(530): 1.[17]Han, Y., Inhomogeneous Calderón reproducing formula on spaces of homogeneous type, J. Geometric Anal.,1997, 7: 259.[18]David, G., Journé, J. L., Semmes, S., Opérateurs de Calderón-Zygmund, fonctions para-accrétives et interpolation, Rev. Mat. Iberoamericana, 1985, 1: 1.[19]Christ, M., A T(b) theorem with remarks on analytic capacity and the Cauchy integral, Colloq. Math., 1990,LX/LXI: 601.[20]Triebel, H., Theory of Function Spaces, Basel: Birkhauser Verlag, 1983.[21]Frazier, M., Jawerth, B., A discrete transform and decompositions of distribution spaces, J. Funct. Anal.,1990, 93: 34.[22]Fefferman, C., Stein, E. M., Some maximal inequalities, Amer. J. Math., 1971, 93: 107.

  12. Isotropic bodies and Bourgain's problem

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    [1]Milman, V. D., Pajor, A., Isotropic position and inertia ellipsoid and zonoids of the unit ball of a normed ndimensional space, Geometric aspects of functional analysis (1987-1988), Lecture Notes in Math., 1989, 1376:64-104.[2]Blaschke, W., Uber affine Geometry ⅩⅣ: eine minimum Aufgabe fur Legendres tragheits Ellipsoid, Ber. verh.sachs. Akad. d. Wiss., 1918, 70: 72-75.[3]Blaschke, W., Uber affine Geometry Ⅺ: losing der "Vierpunkproblems" von Sylvester aus der Teorie der geometrischen Wahrsdeinlichkeiten, Leipziger Berichte, 1917, 69: 436-453.[4]John, F., Polar correspondence with respect to convex regions, Duke Math. J., 1937, 3(2): 355-369.[5]Lutwak, E., Yang, D., Zhang, G., A new ellipsoid associated with convex bodes, Duke. Math. J., 2000, 104:375-390.[6]Bourgain, J., On the distribution of polynomails on high dimensional convex sets, Geometric aspects of functional analysis (1989-1990), Lecture Notes in Math., 1991, 1469: 127-137.[7]Dar, S., Remarks on Bourgain's problem on slicing of convex bodies, Geomitric aspects of functional analysis,in Oper. Theory Adv. Appl., Vol, 77, Basel: Birkhauser, 1995, 61-66.[8]Ball, K., Normed spaces with a weak-Gordon-Lewis property, in: Proc. of Funct. Anal., University of Texas and Austin (1987-1989), Lecture Notes in Math., 1991, 1470: 36-47.[9]Schneider, R., Weil, W., Zonoids and related topics, in Convexity and Its Applications (eds. Gruber, P. M., Wills,J. M.), Basel: Birkhauser, 1983, 296-317.[10]Bourgain, J., Klartag, B., Milman, V., A reduction of the slicing problem to finite volume ratio bodies, Geometry/Functional Analysis, C. R. Acad. Sci. Paris, Ser. I, 2003, 336: 331-334.[11]Ren, D. L., An Introduction to Integral Geometry (in Chinese), Shanghai: Science and Technology Press, 1988.[12]Gardner, R. J., Geometric Tomography, Cambridge: Cambridge University Press, 1995.[13]Leichtweiβ, K., Affine Geometry of Convex Bodies, Heidelberg: J. A. Barth, 1998.[14]Schneider, R., Convex Bodies: The Brunn

  13. Degradação da matéria seca e da proteína bruta de silagens de milho sem espigas com cana -de-açúcar e bagaço de mandioca = Dry mater and crude protein ruminal degradation of corn silage without spikes with sugar cane and manioc pulp

    Directory of Open Access Journals (Sweden)

    Marcos Elias Traad da Silva

    2006-10-01

    Full Text Available A degradação ruminal da matéria seca (MS e da proteína bruta (PB de silagen s de milho sem espigas (SMSE com cana -de-açúcar (CA e bagaço seco de mandioca (BSM, comparadas com a silagem de milho com espigas (SMCE, foi avaliada. A ensilagem foi feita com (CI e sem inoculante (SI - Lactobacillus plantarum e L paracasei ssp. paracasei. Estudaram-se: as frações solúvel (A, potencialmente degradável (B e não degradável (C; a taxa de degradação da fração B (c; a degradabilidade efetiva (DE e potencial (DP, para ostratamentos: T1 (SMSE+20% CA -SI; T2 (SMSE+20% CA -CI; T3 (SMSE+35% CASI; T4 (SMSE+35% CA-CI; T5 (SMSE+20% BSM-SI; T6 (SMSE+20% BSM-CI; T7 (SMSE+35% BSM-SI; T8 (SMSE+35% BSM-CI; T9 (SMCE-SI e T10 (SMCE-CI. As médias foram comparadas num delineamento inteiramente casualisado. Houve diferença (P0,05. A adição de BSM (20 e 35% às SMSE aumentou (PThe goal of this work was to evaluate the ruminal degradation of corn silages without spikes (CSWS, added with sugar cane (SC and dry manioc pulp (DMP, as compared as corn silage (CS. The foods were ensiled with (WI and without (IF inoculant’s, composed by Lactobacillus plantarum and L. paracasei ssp. paracasei. The following fractions have been studied: water soluble (A, potentiallydegradable (B, non degradable (C, fraction B degradable ratio (c; effective (ED and potential (PD degradability. The treatments evaluated were: T1 (CSWS + 20% SC -IF; T2 (CSWS + 20% SC-WI; T3 (CSWS + 35% SC -IF; T4 (CSWS + 35% SC -WI; T5 (CSWS + 20% DMP-IF; T6 (CSWS + 20% DMP -WI; T7 (CSWS + 35% DMP -IF; T8 (CSWS + 35% DMP-WI; T9 (CS-WI and T10 (CS-IF. The average differences havebeen compared on a completely randomized model. Difference (P 0.05 for all treatments. Dry manioc pulp added to the non spikes cornsilage (20 and 35% - DM basis, has allowed the rise of the DM fraction B, indicating the possibility to add up to 35% of dry manioc pulp on corn silage, inst ead of green spikes.

  14. Study on Functional Design, Modular Assembly and Structure-activity Relation of Composition Photocatalytic Materals%复合光催化材料的功能设计、模块化组装及构效关系研究

    Institute of Scientific and Technical Information of China (English)

    何杰

    2016-01-01

    光催化技术是目前研究的热点课题之一,但作为光催化技术研究的核心内容-光催化材料的设计理论与功能组装等方面相对薄弱。该研究拟以材料复合功能设计为目标,模块化组装为手段,研究聚氧钛铌酸盐纳米片-过渡金属离子以及金属氧化物复合光催化剂的设计、组装与构效关系。采用高温固相、聚合-络合等方法合成了规整的层状聚氧钛铌酸盐异构体如KTiNbO5和K3Ti5NbO14等作为光催化材料的基本组元,选用合适的前驱物如硝酸盐或羰基制备对有机硫化物具有吸附作用的吸附模块如Ni2+、Fe3+等离子和NiO和Fe2O3等氧化物,研究模块构建与协同组装技术,构建复合功能光催化材料;以硫醇/硫醚为探针反应物,研究复合光催化材料中有机物富集与光催化氧化功能的耦合。通过XRD、TEM、LRS、UV-vis DRS和FT-IR等表征技术对复合光催化材料的结构、光化学特征以及催化作用进行表征;并探讨了反应机理。结果表明,随着纳米片单元中Ti/Nb的变化,光谱响应特征出现明显的规律,层间过渡金属离子与价带电子轨道发生明显的相互作用改变了带隙能量。氧化物柱撑中前驱物直接影响材料的结构与组元之间的相互作用,并进而影响材料的性能。%Photocatalytic technology is one of the hot topics in current research. However, the theoretical design and functional assembly of the photocatlytic materials are relatively weaker. The purpose of this study is to design composite functional materials using modular assembly technology, as the functional design theory, modular assembly technology and structure-activity relationship of the layered polyoxo-titanoniobate and cation or oxide nano-crystals of transition metal were researched systematically. The layered polyoxo-titanoniobates such as KTiNbO5, and K3Ti5NbO14 etc, as basic modular, which were prepared by polymerization complex method or solid state reaction method. The adsorption modular that adsorbed the organic sulfides, such as Ni2+ and Fe3+ ions, and NiO and Fe2O3, which were prepared by decomposition of its nitrate or carbonyl complexes. The composite functional photocatalytic materials were built by the modular building and colaborative assembly technology. The adsorption and photocatalytic activity was evaluated using ethyl mercaptan/dimethyl sulfide as the probe molecule. X-ray diffraction (XRD), Transmission electron microscopy (TEM), UV-vis diffuse reflectance spectroscopy (UV-vis DRS), and Fourier transform infrared spectroscopy (FT-IR) etc were used to characterize the structure feature and photochemical properties of these composites, and the reaction mechanism also was suggested. The results show that the characteristics of spectral response appear regularity changes with the changes of Ti/Nb of the nanosheet unit. The significant interaction between the transition metal ions of interlayer and the valence band orbital changes the band gap energies, and the preparation method of oxide pilared precursors directly affected the interaction between material structure and the modular units, and further influence the photocatalytic properties of materials.

  15. Consumo, produção de leite e estresse térmico em vacas da raça Pardo-Suíça alimentadas com castanha de caju Dry mater intake, milk yield, and heat stress indicators of dairy cows fed diets with cashew nut

    Directory of Open Access Journals (Sweden)

    P.G. Pimentel

    2007-12-01

    Full Text Available Avaliaram-se o consumo de matéria seca, a produção de leite e os indicadores de estresse térmico de vacas Pardo-Suíça alimentadas com castanha de caju no semi-árido do Nordeste do Brasil. Doze animais foram distribuídos em um ensaio de reversão, com quatro tratamentos: 0, 8, 16 e 24% de castanha no concentrado. As vacas receberam cana-de-açúcar à vontade e sete quilos de concentrado por dia. Maior consumo de matéria seca de cana-de-açúcar foi observado no tratamento com concentrado sem castanha (7,70kgMS/dia em relação aos tratamentos com 16% e 24% de castanha (7,35 e 7,05kgMS/dia, respectivamente. O consumo no tratamento com concentrado sem castanha não diferiu do consumo no tratamento com 8% (7,59kgMS/dia. Não houve efeito dos tratamentos sobre a produção de leite e sobre as variáveis indicativas de estresse térmico (P>0,05.A study was carried out to evaluate dry matter intake, milk yield, and heat stress parameters in Brown Swiss cows fed diets with cashew nut. Animals were raised in the semi-arid region of the Brazilian Northeast. Twelve cows were subjected to a switch back experimental design, with four treatments: 0, 8, 16, and 24% of cashew nut in the concentrate. Each cow received 7kg of concentrate per day and had free access to sugar cane. Dry matter (DM intake and milk yield were daily taken as well as measurements of rectal and milk temperature; and cardiac and respiratory rates. The highest intake of forage (sugar cane was obtained when the concentrate had no cashew nut (7.7kgDM/day. This value was not different when the concentrate contained 8% of cashew nut (7.59kgDM/day but greater than dry matter intake of cows receiving diets with 16% of cashew nut (7.35kgDM/day; P0.05. Such low variability in daily milk yield could be associated with the higher energy density of diets containing more cashew nut. Finally, indicators of heat stress were not influenced by changes in the diets, given the air temperatures and environment where all cows were raised.

  16. Comment on “High-temperature soft magnetic properties of antiperovskite nitrides ZnNFe{sub 3} and AlNFe{sub 3}” by Yankun Fu, Shuai Lin, and Bosen Wang, J. Magn. Magn. Mater. 378 (2015) 54–58

    Energy Technology Data Exchange (ETDEWEB)

    Scholz, T. [Chair of Solid-State and Quantum Chemistry, Institute of Inorganic Chemistry, Landoltweg 1, RWTH Aachen University, D-52056 Aachen (Germany); Leineweber, A. [Institute of Materials Science, TU Bergakademie Freiberg, Gustav-Zeuner-Str. 5, D-09599 Freiberg (Germany); Dronskowski, R., E-mail: drons@HAL9000.ac.rwth-aachen.de [Chair of Solid-State and Quantum Chemistry, Institute of Inorganic Chemistry, Landoltweg 1, RWTH Aachen University, D-52056 Aachen (Germany)

    2016-10-15

    The authors of the aforementioned manuscript have recently claimed the synthesis of the ternary nitrides ZnNFe{sub 3} (=ZnFe{sub 3}N) and AlNFe{sub 3} (=AlFe{sub 3}N), ordered substituted variants of the binary phase γ‘-Fe{sub 4}N [1]. While soft ferromagnets of such kind are presently attracting lots of attention, their history dates back for more than half a century. In particular, Al-substituted γ‘-Fe{sub 4}N has already been mentioned in 1961 [2], and the existence of AlFe{sub 3}N has also been claimed in 2009 [3] from a two-step ammonolysis reaction combining a high-temperature sintering step and a low-temperature nitriding reaction [4]. Nonetheless, one of us had to withdraw the latter claim after finding out, by means of scanning-electron microscopy and elemental mapping, that all samples of “AlFe{sub 3}N” consisted of an intimate solid mixture of γ‘-Fe{sub 4}N and amorphous Al{sub 2}O{sub 3}[5]. From what follows, we have strong reasons to believe that the authors of Ref. [1] overlooked our findings [5] and also did not synthesize ZnFe{sub 3}N and AlFe{sub 3}N. - Highlights: • The synthesis of ZnFe{sub 3}N and AlFe{sub 3}N is questioned. • The diffraction data of ZnFe{sub 3}N and AlFe{sub 3}N resemble those of Fe{sub 4}N. • The magnetic data of ZnFe{sub 3}N and AlFe{sub 3}N are compatible with those of Fe{sub 4}N. • There is no physical evidence for the existence of ZnFe{sub 3}N and AlFe{sub 3}N.

  17. Degradabilidade in situ da silagem de quatro genótipos de sorgo com e sem tanino: I - Matéria seca e proteína bruta In situ degradability of four sorgum silages with or without tannin: I - Dry mater and crude protein

    Directory of Open Access Journals (Sweden)

    W.E. Campos

    2003-04-01

    Full Text Available Avaliaram-se a degradabilidade in situ da matéria seca (MS e da proteína bruta (PB da silagem de quatro genótipos de sorgo, dois com tanino (CMS XS 210 e BR 701 e dois sem tanino (CMS XS 214 e BR007 em um delineamento de blocos inteiramente ao acaso, com três repetições (animais, em arranjo de parcelas subdivididas. Os genótipos constituíram as parcelas e os tempos de digestão as subparcelas. O genótipo CMS XS 210 apresentou menor degradabilidade da MS em relação aos demais e os genótipos que continham tanino (CMS XS 210 e BR 701 apresentaram menores degradabilidades da PB em relação aos que não o continham.The in situ procedure was used to evaluate the disappearance of dry matter (DM and crude protein (CP of four sorghum genotypes with (CMS XS 210 and BR 701 or without (CMS XS 214 and BR 007 tannin in a completely randomized block design experiment with three replicates (animals, in a split plot arrangement. The four genotypes were allotted to the plots and the time of disappearance to the split plot. The DM of CMS XS210 was less degraded when compared to the others and sorghums with tannin showed lower CP degradability when compared to the sorghums without tannin.

  18. 通过富集母血浆中胎儿游离 DNA无创性产前诊断β地中海贫血%Noninvasive prenatal diagnosis ofβ-thalassemia by enriching cell-free fetal DNA in materal plasma

    Institute of Scientific and Technical Information of China (English)

    王青青; 张媛; 章钧; 郝秀兰; 侯红瑛

    2014-01-01

    AIM:To establish a kind of simple and efficient method for cell-free fetal DNA ( cff-DNA) enrich-ment and to investigate its range of applications and the advantages and disadvantages.METHODS:(1) The single nucleo-tide polymorphisms( SNPs) , which linked to paternalβ-thalassemia mutations, were screened.We analyzed the contact be-tween the SNPs inβ-thalassemia gene ( HBB gene) and haploid type by the Haploview software, and then selected these close SNPs which have higher heterozygosity with the HBB gene.(2) We selected 4 cases of different β-thalassemia muta-tions with their husband, and then we used TT-FAST-COLD-PCR to enrich the IVS-II-654 mutations in maternal plasma.If the IVS-II-654 mutation was not detected, we detected the SNP which linked to the IVS-II-654 mutation.Similarly, we used TT-FULL-COLD-PCR to enrich the CD41-42 mutations in the maternal plasma.At the same time, we used the conventional PCR to enrich CD41-42 mutation and IVS-II-654 mutation in the maternal plasma.RESULTS:(1) Nine cases of the SNP ( rs7480526) linked to the mutation at IVS-II-654 in HBB gene, and 11 cases of the SNP ( rs10768683) linked to the muta-tion at CD41-42 in HBB gene were detected.( 2 ) We detected 1 case who inherited the paternal β-thalassemia mutation (IVS-II-654).We did not directly detect patermal IVS-II-654 mutation in maternal plasma, but detected the SNP linked to the IVS-II-654 mutation in the other case and had 100%detection, and 2 cases inherited the paternal β-thalassemia muta-tions (CD41-42) in the maternal plasma by TT-FULL-COLD-PCR and had 100%detection.However, we detected nothing by conventional PCR.CONCLUSION:TT-COLD-PCR is applicable to enrich cell-free fetal DNA in maternal plasma and is a method in the field of noninvasive prenatal diagnosis.%目的:评价富集母血浆中胎儿游离DNA的实验平台在母血浆中富集、鉴定胎儿游离DNA的适用范围。方法:(1)筛选与父源性β地中海贫血基因连锁的单核苷酸多态性( SNP)位点:利用Haploview软件对20例β地中海贫血患者(其中CD41-42型11例,IVS-II-654型9例)的β地中海贫血基因( HBB基因)进行SNP与单倍型自动化分析,检索出HBB基因内杂合度较高的SNP位点并检测与CD41-42位点及IVS-II-654位点连锁的SNP位点。(2)选取4例孕妇外周血标本,且夫妇双方为不同的β地中海贫血基因类型,利用快速耐受温度-低变性温度共扩增PCR技术( TT-FAST-COLD-PCR)检测父源性β地中海贫血基因类型为IVS-II-654型的孕妇外周血标本,若未直接检测到IVS-II-654位点,则检测仅与IVS-II-654位点连锁的SNP位点;同样的原理,利用完全耐受温度-低变性温度共扩增技术( TT-FULL-COLD-PCR)检测父源性β地中海贫血基因类型为CD41-42型的孕妇外周血标本;同时利用普通PCR技术对上述标本进行检测。结果:(1)检测出IVS-II654位点与rs7480526位点连锁9例;CD41-42位点与rs10768683位点连锁11例;(2)通过TT-FAST-COLD-PCR技术在孕妇外周血中检测出1例父源性致病突变基因( IVS-II-654位点),另外1例未直接检测到父源性致病突变基因,但检测到与其连锁的SNP位点( rs7480526位点),与羊水细胞培养检测结果一致,检出率为100%(2/2);通过TT-FULL-COLD-PCR技术在孕妇外周血中检测出2例父源性致病突变基因(CD41-42位点),与羊水细胞培养检测结果一致,检出率为100%(2/2);而普通PCR技术均未检测到上述父源性致病突变基因及与父源性等位基因连锁的SNP位点。结论:TT-COLD-PCR技术适用于富集母血浆中胎儿游离DNA突变,可用于无创性产前诊断单基因遗传病。

  19. 兔颈部硬脊膜表面及椎板旁神经分布的实验研究%Experimental study of nerve fibers' distribution and innervation on the surface of dura mater of spinal cord and lamina of vertebra in rabbits

    Institute of Scientific and Technical Information of China (English)

    左金良; 韩建龙; 韩庆森; 马英文; 秦川

    2006-01-01

    目的:观测兔颈部硬脊膜表面及椎板旁的神经分布规律,为颈性眩晕发病机理的研究提供实验依据.方法:20只新西兰兔,分为硬脊膜实验组及对照组、椎板旁实验侧及对照侧,分别于实验组(侧)(C6硬脊膜或C5椎板表面)喷涂辣根过氧化物酶(HRP)溶液、而对照组(侧)喷涂生理盐水,48h后切取双侧颈上神经节、颈下神经节(或星状神经节)及双侧脊神经节,按TMB法进行成色反应,光镜观察HRP标记细胞形态及其分布情况.利用辣根过氧化物酶逆行示踪技术,了解硬脊膜表面及椎板旁的神经分布规律.结果:硬脊膜实验组双侧C5~C7脊神经节内出现HRP标记细胞,椎板旁实验侧同侧C4~C6脊神经节内出现HRP标记细胞,交感神经节及对照组(侧)脊神经节内未出现标记细胞.结论:颈部硬脊膜表面的神经主要来自双侧脊神经节,相邻节段间有重叠分布;椎板旁的神经主要来自同侧脊神经节,且相邻节段间有重叠.

  20. Diagnosis of Aujeszky's disease virus infection in dogs by use of immunohistochemistry and in-situ hybridization.

    Science.gov (United States)

    Quiroga, M I; Nieto, J M; Sur, J; Osorio, F

    1998-03-01

    Aujeszky's disease (AD) was diagnosed in seven dogs by histological examination, immunohistochemistry and DNA in-situ hybridization. All dogs which lived on two swine farms died spontaneously showing an acute neurological syndrome (hypersalivation, vomiting, pruritus, depression and coma). The most significant histopathological lesion was a non-suppurative encephalitis located in the brain stem, mainly near the floor of the IVth ventricle. Aujeszky's disease virus (ADV) antigen and ADV nucleic acid distribution coincided with the histopathological lesions. However, little ADV antigen and ADV nucleic acid was found in severely damaged areas. A few neurons stained intensely by immunohistochemistry and in-situ hybridization in non-inflammatory areas. Both immunohistochemistry and in-situ hybridization techniques are valid techniques to confirm ADV infection in paraffin-embedded tissues and will be useful for characterizing the pathogenesis of ADV in the central nervous system (CNS) in carnivores.

  1. Aleutian disease of mink: the antibody response of sapphire and pastel mink to Aleutian disease virus.

    Science.gov (United States)

    Bloom, M E; Race, R E; Hadlow, W J; Chesebro, B

    1975-10-01

    The specific antiviral antibody response of sapphire and pastel mink to Pullman strain of ADV has been examined. Sapphire mink inoculated with from 300,000-3 LD50 developed high levels of specific antibody and AD. Pastel mink inoculated with parallel doses of ADV also produced antibody but did not develop AD. The low incidence of AD in pastel mink inoculated with Pullman strain of ADV is probably related to factors other than antiviral antibody.

  2. Fatal systemic adenoviral infection superimposed on pulmonary mucormycosis in a child with acute leukemia

    Science.gov (United States)

    Seo, Yu Mi; Hwang-Bo, Seok; Kim, Seong koo; Han, Seung Beom; Chung, Nack-Gyun; Kang, Jin Han

    2016-01-01

    Abstract Background: Although adenovirus (ADV) infection usually causes self-limiting respiratory disorders in immune competent children; severe and systemic ADV infection in children undergoing chemotherapy for leukemia has been continuously reported. Nevertheless, there has been no consensus on risk factors and treatment strategies for severe ADV infection in children undergoing chemotherapy. Case summary: We report a case of a 15-year-old boy with a fatal systemic ADV infection. He had received reinduction chemotherapy for relapsed acute lymphoblastic leukemia under continuing antifungal therapy for previously diagnosed fungal pneumonia. He complained of fever and right shoulder pain 4 days after completing the reinduction chemotherapy. In spite of appropriate antibiotic and antifungal therapy, pneumonia was aggravated and gross hematuria was accompanied. A multiplex polymerase chain reaction test for respiratory viruses was positive for ADV in a blood sample, and a urine culture was positive for ADV. He received oral ribavirin, intravenous immunoglobulin, and intravenous cidofovir therapy; however, he eventually died. Relapsed leukemia, concurrent fungal pneumonia, and delayed cidofovir administration were considered the cause of the grave outcome in this patient. Conclusion: ADV may cause severe infections not only in allogeneic hematopoietic cell transplant recipients, but also in patients undergoing chemotherapy for acute leukemia. The risk factors for severe ADV infection in patients undergoing chemotherapy should be determined in the future studies, and early antiviral therapy should be administered to immune compromised patients with systemic ADV infection. PMID:27749571

  3. Prognostics Health Management for Advanced Small Modular Reactor Passive Components

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Ryan M.; Ramuhalli, Pradeep; Coble, Jamie B.; Mitchell, Mark R.; Wootan, David W.; Hirt, Evelyn H.; Berglin, Eric J.; Bond, Leonard J.; Henager, Charles H.

    2013-10-18

    In the United States, sustainable nuclear power to promote energy security is a key national energy priority. Advanced small modular reactors (AdvSMR), which are based on modularization of advanced reactor concepts using non-light-water reactor (LWR) coolants such as liquid metal, helium, or liquid salt may provide a longer-term alternative to more conventional LWR-based concepts. The economics of AdvSMRs will be impacted by the reduced economy-of-scale savings when compared to traditional LWRs and the controllable day-to-day costs of AdvSMRs are expected to be dominated by operations and maintenance costs. Therefore, achieving the full benefits of AdvSMR deployment requires a new paradigm for plant design and management. In this context, prognostic health management of passive components in AdvSMRs can play a key role in enabling the economic deployment of AdvSMRs. In this paper, the background of AdvSMRs is discussed from which requirements for PHM systems are derived. The particle filter technique is proposed as a prognostics framework for AdvSMR passive components and the suitability of the particle filter technique is illustrated by using it to forecast thermal creep degradation using a physics-of-failure model and based on a combination of types of measurements conceived for passive AdvSMR components.

  4. 77 FR 49463 - National Science Board; Sunshine Act Meetings

    Science.gov (United States)

    2012-08-16

    ....m. SUBJECT MATTER: Chairman's remarks, discussion of Advanced Laser Interferometer Gravitational Wave Observatory (AdvLIGO) Construction Project Change in Scope, and discussion of and action on...

  5. Cardiac abnormalities in adults with the attenuated form of mucopolysaccharidosis type I

    NARCIS (Netherlands)

    O.I.I. Soliman (Osama Ibrahim Ibrahim); R.G.M. Timmermans (Remco); A. Nemes (Attila); W.B. Vletter (Wim); J.H.P. Wilson (Paul); F.J. ten Cate (Folkert); M.L. Geleijnse (Marcel)

    2007-01-01

    textabstractBackground: Cardiac involvement in mucopolysaccharidosis type I (MPS I) has been studied primarily in its most severe forms. Cardiac involvement, particularly left ventricular (LV) systolic and diastolic function, in the attenuated form of MPS I is less well known. Methods: Cardiac funct

  6. Transcriptional interactions suggest niche segregation among microorganisms in the human gut

    DEFF Research Database (Denmark)

    Plichta, Damian Rafal; Juncker, Agnieszka; dos Santos, Marcelo Bertalan Quintanilha

    2016-01-01

    The human gastrointestinal (GI) tract is the habitat for hundreds of microbial species, of which many cannot be cultivated readily, presumably because of the dependencies between species 1. Studies of microbial co-occurrence in the gut have indicated community substructures that may reflect funct...

  7. Ecological, Social and Economic Evaluation of Transport Scenarios: An Integral Approach. A Phd research programme

    NARCIS (Netherlands)

    Geurs KT; LAE

    2000-01-01

    This report describes a research programme for the development of a methodology for the integral assessment of ecological, economic and social impacts of transport scenarios. The following research activities are planned: (1) a literature study on theories and conceptual models, explaining the funct

  8. The Impact of Mitochondrial Complex Inhibition on mESC Differentiation

    Science.gov (United States)

    The Impact of Mitochondrial Complex Inhibition on mESC Differentiation JE Royland, SH Warren, S Jeffay, MR Hoopes, HP Nichols, ES Hunter U.S. Environmental Protection Agency, Integrated Systems Toxicology Division, Research Triangle Park, NC The importance of mitochondrial funct...

  9. Normalization of serum calcium by cinacalcet in a patient with hypercalcaemia due to a de novo inactivating mutation of the calcium-sensing receptor.

    NARCIS (Netherlands)

    Timmers, H.J.L.M.; Karperien, M.; Hamdy, N.A.; Boer, H. de; Hermus, A.R.M.M.

    2006-01-01

    Familial benign hypocalciuric hypercalcaemia (FHH) results from a heterozygous inactivating mutation of the calcium-sensing receptor (CaR) and is characterized by hypercalcaemia, hypocalciuria and inappropriately normal plasma levels of parathyroid hormone. In a minority of patients, a loss of funct

  10. The role of the International Telecommunication Union

    NARCIS (Netherlands)

    Shahin, J.

    2010-01-01

    The global telecommunications sector, and its associ- ated policy environment, has been subject to remark- able upheaval in recent decades. Throughout these reconfigurations of the very backbone of the global communications network, one institution has man- aged to survive, evolve and continue funct

  11. Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons

    DEFF Research Database (Denmark)

    Bauer, Matthias; Szulc, Jolanta; Meyer, Morten

    2008-01-01

    Delta-like 1 (Dlk1), a member of the Delta/Notch protein family, is expressed in the mouse ventral midbrain (VM) as early as embryonic day 11.5 (E11.5) followed by exclusive expression in tyrosine 3-monooxygenase (TH) positive neurons from E12.5 onwards. To further elucidate the yet unknown funct...

  12. Manual therapy with or without physical medicine modalities for neck pain: a systematic review

    NARCIS (Netherlands)

    J. D'Sylva; J. Miller; A. Gross; S.J. Burnie; C.H. Goldsmith; N. Graham; T. Haines; G. Brønfort; J.L. Hoving

    2010-01-01

    Manual therapy interventions are often used with or without physical medicine modalities to treat neck pain. This review assessed the effect of 1) manipulation and mobilisation, 2) manipulation, mobilisation and soft tissue work, and 3) manual therapy with physical medicine modalities on pain, funct

  13. Human hand modelling: kinematics, dynamics, applications

    NARCIS (Netherlands)

    Gustus, A.; Stillfried, G.; Visser, J.; Jörntell, H.; Van der Smagt, P.

    2012-01-01

    An overview of mathematical modelling of the human hand is given. We consider hand models from a specific background: rather than studying hands for surgical or similar goals, we target at providing a set of tools with which human grasping and manipulation capabilities can be studied, and hand funct

  14. A Banach algebra of functions of several variables of finite total variation and Lipschitzian superposition operators. I

    NARCIS (Netherlands)

    Chistyakov, VV

    2005-01-01

    It is shown that the space of functions of n real variables with finite total variation in the sense of Vitali, Hardy and Krause, defined on a rectangle I-a(b) C R-n, is a Banach algebra under the pointwise operations and Hildebrandt-Leonov's norm. This result generalizes the classical case of funct

  15. Association mapping across numerous traits reveals patterns of functional variation in maize

    Science.gov (United States)

    Phenotypic variation in natural populations results from a combination of genetic effects, environmental effects, and gene-by-environment interactions. Despite the vast amount of genomic data becoming available, many pressing questions remain about the nature of genetic mutations that underlie funct...

  16. Sequence Classification: 892754 [

    Lifescience Database Archive (English)

    Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|6323393|ref|NP_013465.1| Putative phosphoesterase that funct...ions as a dosage-dependent positive regulator of the G1/S phase transition by contr

  17. Linear operator inequalities for strongly stable weakly regular linear systems

    NARCIS (Netherlands)

    Curtain, RF

    2001-01-01

    We consider the question of the existence of solutions to certain linear operator inequalities (Lur'e equations) for strongly stable, weakly regular linear systems with generating operators A, B, C, 0. These operator inequalities are related to the spectral factorization of an associated Popov funct

  18. Intensity, but not duration, of physical activities is related to cognitive function

    NARCIS (Netherlands)

    Angevaren, Maaike; Vanhees, Luc; Wendel-Vos, Wanda; Verhaar, Harald J. J.; Aufdernkarnpe, Geert; Aleman, Andrie; Verschuren, W. M. Monique

    2007-01-01

    Background Physical activity is thought to facilitate cognitive performance and to slow down the rate of age-related cognitive decline. This study aimed to investigate the association between the time spent on physical activity as well as the average intensity of these activities and cognitive funct

  19. Comparing the social costs of biofuels and fossil fuels: A case study of Vietnam

    NARCIS (Netherlands)

    Thanh, le L.; Ierland, van E.C.; Zhu, X.; Wesseler, J.H.H.; Ngo, G.

    2013-01-01

    Biofuel substitution for fossil fuels has been recommended in the literature and promoted in many countries; however, there are concerns about its economic viability. In this paper we focus on the cost-effectiveness of fuels, i.e., we compare the social costs of biofuels and fossil fuels for a funct

  20. Experimental verification of Lorentz' linearization procedure for quadratic friction

    NARCIS (Netherlands)

    G.M. Terra; W.J. van den Berg; L.R.M. Maas

    2005-01-01

    Abstract: We present results from laboratory experiments in a ‘tidal tank’, demonstrating the resonant response of the Helmholtz mode in an almost-enclosed basin. In particular the dependence of the response curve (amplification of the tide in the basin relative to the tidal signal at sea as a funct

  1. Standardization of lower secondary civic education and inequality of the civic and political engagement of students

    NARCIS (Netherlands)

    Witschge, J.; van de Werfhorst, H.G.

    2016-01-01

    In this paper, the relation between the standardization of civic education and the inequality of civic engagement is examined. Using data from the International Civic and Citizenship Education Study 2009 among early adolescents and Eurydice country-level data, three-level analysis and variance funct

  2. Non-Invasive Markers of Tumor Growth, Metastases, and Sensitivity to Anti-Neoplastic Therapy

    Science.gov (United States)

    2009-01-01

    ally about 10 days after implantation on the thigh region and volume increased to 800 mm3 to 2600 mm3 (not cor- rected for skin thickness) in an...N. In vivo proton magnetic resonance spectroscopy of brain tumors. Stereotact Funct Neurosurg 2000;74:83–94. 3. Tosi MR, Fini G, Tinti A, Reggiani A

  3. New developments in functional medical textiles and their mechanism of action

    Science.gov (United States)

    Functional medical textiles are undergoing a revolution in structural design. Medical textiles as non-implantables, implantables, and extracorporeals, are playing central roles in healthcare improvements enhancing and prolonging the quality of life. Developments in the design of materials that funct...

  4. Soil management options to sequester carbon and mitigate the greenhouse effect

    NARCIS (Netherlands)

    Batjes, N.H.

    2000-01-01

    The imbalance between global sources and sinks in the global budget of atmospheric CO2 is one of the most important problems in the study of global change. At present there is a 'missing sink' of about 1-2 Pg C yr -1. It is likely that a major part of this sink for carbon is to be found in the funct

  5. Transcriptional control of hepatocanalicular transporter gene expression

    NARCIS (Netherlands)

    Muller, M

    2000-01-01

    Transport processes for larger organic solutes at the canalicular membrane are mainly driven by members of the superfamily of ATP-binding cassette (ABC) transporters. The funct ions of these transporters range from bile component secretion to xenobiotica and phase II-conjugate export. The transcript

  6. A control strategy for multi-functional converter to improve grid power quality

    DEFF Research Database (Denmark)

    Li, Fei; Wang, Xiongfei; Chen, Zhe

    2011-01-01

    The extensive use of converter-interfacing distributed energy resources (DER), combined with a large amount of nonlinear and unbalanced loads connected to the distribution power system, has led to power quality problem. This paper proposes a control strategy for a three-phase four-leg multi-funct...

  7. Functional and bioinformatics analysis of two Campylobacter jejuni homologs of the thiol-disulfide oxidoreductase, DsbA

    NARCIS (Netherlands)

    Grabowska, Anna D; Wywiał, Ewa; Dunin-Horkawicz, Stanislaw; Łasica, Anna M; Wosten, M.M.S.M; Nagy-Staroń, Anna; Godlewska, Renata; Bocian-Ostrzycka, Katarzyna; Pieńkowska, Katarzyna; Łaniewski, Paweł; Bujnicki, Janusz M; van Putten, Jos P M; Jagusztyn-Krynicka, E Katarzyna

    2014-01-01

    BACKGROUND: Bacterial Dsb enzymes are involved in the oxidative folding of many proteins, through the formation of disulfide bonds between their cysteine residues. The Dsb protein network has been well characterized in cells of the model microorganism Escherichia coli. To gain insight into the funct

  8. Immune evasion by pseudomonal proteases

    NARCIS (Netherlands)

    Bardoel, B.W.

    2011-01-01

    The innate immune system recognizes and rapidly kills invading bacteria via different mechanisms. Bacteria exploit several strategies to evade recognition by the immune system in order to survive within the host. An important strategy of bacteria is the secretion of proteins that block crucial funct

  9. New molecular targets for PET and SPECT imaging in neurodegenerative diseases

    NARCIS (Netherlands)

    Benadiba, Marcel; Luurtsema, Gert; Wichert-Ana, Lauro; Buchpigel, Carlos Alberto; Busatto Filho, Geraldo

    2012-01-01

    The pathophysiology of neurodegenerative diseases (ND) such as Alzheimer's disease (AD) and Parkinson's disease (PD) has not yet been completely elucidated. However, in the past few years, there have been great knowledge advances about intra-and extracellular proteins that may display impaired funct

  10. Personality disorders and social functioning in depressed patients

    NARCIS (Netherlands)

    Kool, S; Dekker, J; Duijsens, [No Value; de Jonghe, F; de Jong, P; Schouws, S

    2000-01-01

    There is a high level of comorbidity of personality disorders with major depression. Patients who suffer from both depression and an axis II disorder are, in general, more severely ill and ill for longer periods. The presence of personality disorders also has a negative influence on the social funct

  11. Unilateral Tinnitus : Changes in Connectivity and Response Lateralization Measured with fMRI

    NARCIS (Netherlands)

    Lanting, Cornelis P.; de Kleine, Emile; Langers, Dave R. M.; van Dijk, Pim

    2014-01-01

    Tinnitus is a percept of sound that is not related to an acoustic source outside the body. For many forms of tinnitus, mechanisms in the central nervous system are believed to play a role in the pathology. In this work we specifically assessed possible neural correlates of unilateral tinnitus. Funct

  12. CRYSTAL-STRUCTURES OF HEVAMINE, A PLANT DEFENSE PROTEIN WITH CHITINASE AND LYSOZYME ACTIVITY, AND ITS COMPLEX WITH AN INHIBITOR

    NARCIS (Netherlands)

    VANSCHELTINGA, ACT; KALK, KH; BEINTEMA, JJ; DIJKSTRA, BW

    1994-01-01

    Background: Hevamine is a member of one of several families of plant chitinases and lysozymes that are important for plant defence against pathogenic bacteria and fungi. The enzyme can hydrolyze the linear polysaccharide chains of chitin and peptidoglycan. A full understanding of the structure/funct

  13. Standardization of lower secondary civic education and inequality of the civic and political engagement of students

    NARCIS (Netherlands)

    J. Witschge; H.G. van de Werfhorst

    2015-01-01

    In this paper, the relation between the standardization of civic education and the inequality of civic engagement is examined. Using data from the International Civic and Citizenship Education Study 2009 among early adolescents and Eurydice country-level data, three-level analysis and variance funct

  14. Strichartz Estimates for the Schrödinger Propagator for the Laguerre Operator

    Indian Academy of Sciences (India)

    Vijay Kumar Sohani

    2013-11-01

    We obtain homogeneous Strichartz estimate for the Schrödinger propagator $e^{-itL_}$ for the Laguerre operator $L_$ on $\\mathbb{R}^n_+$. We follow regularization technique as introduced in J. Funct. Anal. 224(2) (2005) 371–385. We also establish inhomogeneous Strichartz estimates for different admissible pairs.

  15. Disease: H01184 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H01184 Familial dementia, including: Familial British dementia (FBD); Familial Dani...sh dementia (FDD) Familial British dementia (FBD) and familial Danish dementia (FDD) are two autosomal domin... 117300 PMID:19779737 Garringer HJ, Murrell J, D'Adamio L, Ghetti B, Vidal R Modeling familial British and Danish dementia. Brain Struct Funct 214:235-44 (2010) ...

  16. Velocity profiles in strongly turbulent Taylor-Couette flow

    NARCIS (Netherlands)

    Grossmann, S.; Lohse, D.; Sun, C.

    2014-01-01

    We derive the velocity profiles in strongly turbulent Taylor-Couette flow for the general case of independently rotating cylinders. The theory is based on the Navier-Stokes equations in the appropriate (cylinder) geometry. In particular, we derive the axial and the angular velocity profiles as funct

  17. 12.DIGESTIVE TRACT 12.1.Esophagus

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920110 The clinical study on gastroeso-phageal reflux.LUO Jinyan (罗金燕),et al.Digest Funct Lab,2nd Affil Hosp,Xian Med Univ.Chin J Digest 1991; 11(3): 137-140.Fifty-two patients with symptomatic gas-troesophageal reflux (GER) were studied withprolonged intraesopnageal pH monitoring,scin-

  18. Averaging of random sets based on their distance functions

    NARCIS (Netherlands)

    Baddeley, A.J.; Molchanov, I.S.

    1995-01-01

    A new notion of expectation (or distance average) of random closed sets based on their distance function representation is introduced. A general concept of the distance function is exploited to define the expectation, which is the set whose distance function is closest to the expected distance funct

  19. Strategies for structuring interdisciplinary education in Systems Biology: an European perspective

    NARCIS (Netherlands)

    Cvijovic, Marija; Höfer, Thomas; Acimovic, Jure; Alberghina, Lilia; Almaas, Eivind; Besozzi, Daniela; Blomberg, Anders; Bretschneider, Till; Cascante, Marta; Collin, Olivier; Atauri, de Pedro; Depner, Cornelia; Dickinson, Robert; Dobrzynski, Maciej; Fleck, C.; Garcia-Ojalvo, Jordi; Gonze, Didier; Hahn, Jens; Hess, Heide Marie; Hollmann, Susanne; Krantz, Marcus; Kummer, Ursula; Lundh, Torbjörn; Martial, Gifta; Martins dos Santos, V.A.P.; Mauer-Oberthür, Angela; Regierer, Babette; Skene, Barbara; Stalidzans, Egils; Stelling, Jörg; Teusink, Bas; Workman, Christopher T.; Hohmann, Stefan

    2016-01-01

    Systems Biology is an approach to biology and medicine that has the potential to lead to a better understanding of how biological properties emerge from the interaction of genes, proteins, molecules, cells and organisms. The approach aims at elucidating how these interactions govern biological funct

  20. Origin, Impact and Cost of Interface Instability

    NARCIS (Netherlands)

    Raemaekers, S.B.A.

    2015-01-01

    Third-party libraries are used frequently in modern software development. Websites that are visited millions of times a day often make heavy use of open-source software libraries. As a software developer, using these libraries has a number of advantages. Developers save time and effort because funct

  1. The effects of sensory impairments on product experience and personal well-being

    NARCIS (Netherlands)

    Schifferstein, H.N.J.; Desmet, P.M.A.

    2007-01-01

    To determine the roles the sensory modalities play in user-product interactions, one modality was blocked during the execution of eight simple tasks. Participants reported how they experienced the products and how they felt during the experiment. Blocking vision resulted in the largest loss of funct

  2. The role of leadership in regional climate change adaptation: a comparison of adaptation practices initiated by governmental and non-governmental actors

    NARCIS (Netherlands)

    Meijerink, S.V.; Stiller, S.J.; Carina, E.; Keskitalo, K; Scholten, P.; Smits, R; Lamoen, F van

    2015-01-01

    This paper aims to better understand the role of leadership in regional climate change adaptation. We first present a framework, which distinguishes five functions of leadership within inter-organizational networks: the connective, enabling, adaptive, political–administrative and dissemination funct

  3. Controlling Cellular Endocytosis at the Nanoscale

    Science.gov (United States)

    Battaglia, Giuseppe

    2011-03-01

    , amphiphilic molecules, and hydrophilic molecules without affecting the viability of cells or even triggering inflammatory pathways. Finally we show how size, surface chemistry and surface topology of the vesicles affect their interaction with the cell membrane and hence their cellular uptake. References: C. Lo Presti, M. Massignani, T. Smart, H. Lomas, and G. Battaglia J. Mater. Chem. (2009) 19, 3576-3590 H. Lomas, I. Canton, S. MacNeil, J. Du, S.P. Armes, A.J. Ryan, A.L. Lewis and G. Battaglia Adv. Mater. (2007). 19, 4238-4243 M. Massignani, I. Canton, N. Patikarnmonthon, N. J. Warren, S. P. Armes, A. L. Lewis and G. Battaglia, Nature Prec., 2010, http://hdl.handle.net/10101/npre.2010.4427.1 M. Massignani, C. LoPresti, A. Blanazs, J. Madsen, S. P. Armes, A. L. Lewis and G. Battaglia Small, 2009, 5, 2424-2432. M. Massignani, T. Sun, A. Blanazs, V. Hearnden, I. Canton, P. Desphande, S. Armes, S. MacNeil, A. Lewis and G. Battaglia PLoS One, 2010, 5, e10459.

  4. Rapid analysis of trace pollutants using laser mass spectrometry

    Institute of Scientific and Technical Information of China (English)

    WEI; Jie

    2001-01-01

    [1]Otsuka,K.,Kubo,H.,Wayman,C.M.,Diffuse electron scattering and “streaming” effect,Metall.Trans.A,1981,12:595-605.[2]Otsuka,K.,Wayman,C.M.,Kubo,H.,Diffuse electron scattering in β-phase alloys,Metall.Trans.A,1978,9:1075-1085.[3]Singh,J.,Chen,H.,Wayman,C.M.,Transformation sequence in a Cu-Al-Ni shape memory alloy at elevated temperatures,Metall.Trans.A,1986,17:65-72.[4]Sun,Y.S.,Lorimer,G.W.,Ridley,N.,Microstructure and its development in Cu-Al-Ni alloys,Metall.Trans.A,1990,21:575-588.[5]Miyazaki,S.,Kawai,T.,Otsuka,K.,On the origin of intergranular fracture in β phase shape memory alloys,Scripta Metall.,1982,16:431-436.[6]Otsuka,K.,Wayman,C.M.,Naka,K.et al.,Superelasticity effects and stress-induced martensitic transformations in Cu-Al-Ni alloys,Acta Metall.,1976,24:207-226.[7]Otsuka,K.,Sakamoto,H.,Shimizu,K.,Successive stress-induced martensitic transformations and associated transformation pseudoelasticity in Cu-Al-Ni alloys,Acta Metall.,1979,27:585-600.[8]Shield,T.W.,Orientation dependence of the pseudoelastic behavior of single crystal of Cu-Al-Ni in tension,J.Mech.Phys.Solids,1995,43(6):869-895.[9]Sun,Q.P.,Zhang,X.Y.,Xu,T.,Experimental study of martensitic transformation in single shape memory alloy,Adv.Solids Mech.,1997,7:155-162.[10]Chen,Q.Z.,Chu,W.Y.,Hsiao,C.M.,In-situ TEM observation of nucleation and bluntness of nanocrack in 310 stainless steel,Acta Metall.Mater.,1995,43:4371-4376.[11]Chu,W.Y.,Gao,K.W.,Wang,Y.B.et al.,Nucleating and propagation of nanocrack in dislocation free zone in brittle material,Science in China,Ser.A,1995,38(14):1501-1509.[12]Chen,Q.Z.,Gao,K.W.,Gu,B.et al.,Nucleating,blunting and propagation of A nanocrack in DFZ of thin crystals,Fatigue Frac.Eng.Mater.Stru.,1996,21:1415-1423.[13]Nishiyama,Z.,Stacking faults in the martensite of Cu-Al alloy,Journal of the Physical Society of Japan,1965,20:1192-1121.[14]Lovey,F.C.,Van Tendeloo,G.,Van Landuyt,J.et al.,HREM imaging

  5. In-situ study of martensitic transformation and nucleation,propagation of crack in CuNiAl shape memory alloy

    Institute of Scientific and Technical Information of China (English)

    LU; Yonghao

    2001-01-01

    [1]Otsuka,K.,Kubo,H.,Wayman,C.M.,Diffuse electron scattering and “streaming” effect,Metall.Trans.A,1981,12:595-605.[2]Otsuka,K.,Wayman,C.M.,Kubo,H.,Diffuse electron scattering in β-phase alloys,Metall.Trans.A,1978,9:1075-1085.[3]Singh,J.,Chen,H.,Wayman,C.M.,Transformation sequence in a Cu-Al-Ni shape memory alloy at elevated temperatures,Metall.Trans.A,1986,17:65-72.[4]Sun,Y.S.,Lorimer,G.W.,Ridley,N.,Microstructure and its development in Cu-Al-Ni alloys,Metall.Trans.A,1990,21:575-588.[5]Miyazaki,S.,Kawai,T.,Otsuka,K.,On the origin of intergranular fracture in β phase shape memory alloys,Scripta Metall.,1982,16:431-436.[6]Otsuka,K.,Wayman,C.M.,Naka,K.et al.,Superelasticity effects and stress-induced martensitic transformations in Cu-Al-Ni alloys,Acta Metall.,1976,24:207-226.[7]Otsuka,K.,Sakamoto,H.,Shimizu,K.,Successive stress-induced martensitic transformations and associated transformation pseudoelasticity in Cu-Al-Ni alloys,Acta Metall.,1979,27:585-600.[8]Shield,T.W.,Orientation dependence of the pseudoelastic behavior of single crystal of Cu-Al-Ni in tension,J.Mech.Phys.Solids,1995,43(6):869-895.[9]Sun,Q.P.,Zhang,X.Y.,Xu,T.,Experimental study of martensitic transformation in single shape memory alloy,Adv.Solids Mech.,1997,7:155-162.[10]Chen,Q.Z.,Chu,W.Y.,Hsiao,C.M.,In-situ TEM observation of nucleation and bluntness of nanocrack in 310 stainless steel,Acta Metall.Mater.,1995,43:4371-4376.[11]Chu,W.Y.,Gao,K.W.,Wang,Y.B.et al.,Nucleating and propagation of nanocrack in dislocation free zone in brittle material,Science in China,Ser.A,1995,38(14):1501-1509.[12]Chen,Q.Z.,Gao,K.W.,Gu,B.et al.,Nucleating,blunting and propagation of A nanocrack in DFZ of thin crystals,Fatigue Frac.Eng.Mater.Stru.,1996,21:1415-1423.[13]Nishiyama,Z.,Stacking faults in the martensite of Cu-Al alloy,Journal of the Physical Society of Japan,1965,20:1192-1121.[14]Lovey,F.C.,Van Tendeloo,G.,Van Landuyt,J.et al.,HREM imaging

  6. Highly-efficient all-dielectric Huygens' surface holograms (Conference Presentation)

    Science.gov (United States)

    Chong, Katie; Wang, Lei; Staude, Isabelle; James, Anthony; Dominguez, Jason; Subramania, Ganapathi; Liu, Sheng; Decker, Manuel; Neshev, Dragomir N.; Brener, Igal; Kivshar, Yuri S.

    2016-04-01

    that lack dissipative losses and also suppress unwanted reflections without relying on cross-polarization schemes that additionally suffer from polarization-conversion losses. We now use such Huygens' surfaces in order to create a highly-efficient phase masks for the generation of optical holograms. By varying only one geometrical parameter, namely the lattice periodicity that can be controlled easily during the fabrication process we can effectively generate arbitrary hologram images from a 4-level phase discretization. In order to design the arrangement of the pixels in the metasurfaces, we calculate the phase mask required for a hologram generating the letters `hv' in the hologram plane. In the next step the Huygens' hologram is fabricated on a back-side polished SOI wafer by electron-beam lithography followed by a reactive-ion etching process. Then, we measure the phase of the generated hologram using a home-built Mach-Zehnder interferometer and perform a phase retrieval process to compare the experimental phase with the designed phase. Finally, we record the holographic image in the hologram plane and demonstrate that the device functionality is completely polarization insensitive with a transmission efficiency of 82%, in contrast to all the earlier works utilizing geometric phase. References [1] Yu et al., Nat. Mater. 13, 139 (2014). [2] Pfeiffer et al., Phys. Rev. Lett. 110, 197401 (2013). [3] Monticone et al., Phys. Rev. Lett. 110, 203903 (2013). [4] Decker et al., Adv. Opt. Mater. 3, 813 (2015).

  7. Foreword: Focus on Superconductivity in Semiconductors

    Directory of Open Access Journals (Sweden)

    Yoshihiko Takano

    2008-01-01

    Full Text Available Since the discovery of superconductivity in diamond, much attention has been given to the issue of superconductivity in semiconductors. Because diamond has a large band gap of 5.5 eV, it is called a wide-gap semiconductor. Upon heavy boron doping over 3×1020 cm−3, diamond becomes metallic and demonstrates superconductivity at temperatures below 11.4 K. This discovery implies that a semiconductor can become a superconductor upon carrier doping. Recently, superconductivity was also discovered in boron-doped silicon and SiC semiconductors. The number of superconducting semiconductors has increased. In 2008 an Fe-based superconductor was discovered in a research project on carrier doping in a LaCuSeO wide-gap semiconductor. This discovery enhanced research activities in the field of superconductivity, where many scientists place particular importance on superconductivity in semiconductors.This focus issue features a variety of topics on superconductivity in semiconductors selected from the 2nd International Workshop on Superconductivity in Diamond and Related Materials (IWSDRM2008, which was held at the National Institute for Materials Science (NIMS, Tsukuba, Japan in July 2008. The 1st workshop was held in 2005 and was published as a special issue in Science and Technology of Advanced Materials (STAM in 2006 (Takano 2006 Sci. Technol. Adv. Mater. 7 S1.The selection of papers describe many important experimental and theoretical studies on superconductivity in semiconductors. Topics on boron-doped diamond include isotope effects (Ekimov et al and the detailed structure of boron sites, and the relation between superconductivity and disorder induced by boron doping. Regarding other semiconductors, the superconducting properties of silicon and SiC (Kriener et al, Muranaka et al and Yanase et al are discussed, and In2O3 (Makise et al is presented as a new superconducting semiconductor. Iron-based superconductors are presented as a new series of high

  8. Nanostructured silicon via metal assisted catalyzed etch (MACE): chemistry fundamentals and pattern engineering

    Science.gov (United States)

    Toor, Fatima; Miller, Jeffrey B.; Davidson, Lauren M.; Nichols, Logan; Duan, Wenqi; Jura, Michael P.; Yim, Joanne; Forziati, Joanne; Black, Marcie R.

    2016-10-01

    There are a range of different methods to generate a nanostructured surface on silicon (Si) but the most cost effective and optically interesting is the metal assisted wet chemical etching (MACE) (Koynov et al 2006 Appl. Phys. Lett. 88 203107). MACE of Si is a controllable, room-temperature wet-chemical technique that uses a thin layer of metal to etch the surface of Si, leaving behind various nano- and micro-scale surface features or ‘black silicon’. MACE-fabricated nanowires (NWs) provide improved antireflection and light trapping functionality (Toor et al 2016 Nanoscale 8 15448-66) compared with the traditional ‘iso-texturing’ (Campbell and Green 1987 J. Appl. Phys. 62 243-9). The resulting lower reflection and improved light trapping can lead to higher short circuit currents in NW solar cells (Toor et al 2011 Appl. Phys. Lett. 99 103501). In addition, NW cells can have higher fill factors and voltages than traditionally processed cells, thus leading to increased solar cell efficiencies (Cabrera et al 2013 IEEE J. Photovolt. 3 102-7). MACE NW processing also has synergy with next generation Si solar cell designs, such as thin epitaxial-Si and passivated emitter rear contact (Toor et al 2016 Nanoscale 8 15448-66). While several companies have begun manufacturing black Si, and many more are researching these techniques, much of the work has not been published in traditional journals and is publicly available only through conference proceedings and patent publications, which makes learning the field challenging. There have been three specialized review articles published recently on certain aspects of MACE or black Si, but do not present a full review that would benefit the industry (Liu et al 2014 Energy Environ. Sci. 7 3223-63 Yusufoglu et al 2015 IEEE J. Photovolt. 5 320-8 Huang et al 2011 Adv. Mater. 23 285-308). In this feature article, we review the chemistry of MACE and explore how changing parameters in the wet etch process effects the resulting

  9. Optimization of control parameters of CdZnTe ACRT-Bridgman single crystal growth

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    . G., The modelling of heat transfer in the melt volume during crystal growth by the Stockbarger method using ACRT, J. Cryst. Growth, 1999, 207: 226-231.[14]Distanov, V. E., Kirdyashkin, A. G., The influence of accelerated crucible rotation mode on the melt temperature field in the Stockbarger technique, J. Cryst. Growth, 2001, 222: 607-614.[15]Capper, P., Gosney, J. J. G., Jones, C. L. Et al., Bridgman growth of CdxHg1-xTe using ACRT, Journal of Electronic Materials, 1986, 15: 371-376.[16]Capper, P., Bridgman growth of CdxHg1-xTe--A review, Prog. Cryst. Growth and Gharact., 1989, 19: 259-293.[17]Capper, P., A review of impurity behavior in bulk and epitaxial of Hg1-xCdxTe, J. Vac. Sci. Techonol. B, 1991, 9(3): 1667-1681.[18]Capper, P., Harris, J. E., O'Keefe, E. et al., Bridgman growth and assessment of CdTe and CdZnTe using the accelerated crucible rotation technique, Mater. Sci. Eng. B, 1993, 16(1-3): 29-39.[19]Capper, P., Harris, J. E., Okeeffe, E. S., Macrosegregation and microsegredation of Zn in Bridgman-grown CdZnTe, Adv. Mater. Opt. Electr., 1995, 5(2): 101-108.[20]Capper, P., Bulk Bridgman growth of cadmium mercury telluride for IR applications, J. Mater. Sci.-Mater. EL, 2001, 12: 423-428.[21]Jie, W., Li, Y., Liu, X., Solute redistribution during the accelerated crucible rotation Bridgman growth of Hg1-xMnxTe, J. Cryst. Growth, 1999, 205: 510-514.[22]Dixit, V. K., Rodrigues, B. V., Bhat, H. L., Growth of InSb(1-x)Bix crystals by rotatory Bridgman method and their characterization, J. Cryst. Growth, 2000, 217: 40-46.[23]Brice, J. C., Capper, P., Jones, C. L. et al., ACRT: A review of models, Prog. Crystal Growth and Gharact., 1986, 13: 197-229.[24]Liu Juncheng, Jie Wanqi, Zhou Yaohe, Experimental Study of the ACRT Ekman flow, Acta Metallurgica Sinica, 1996, 32: 269-273.[25]Liu Juncheng, Jie Wanqi, Zhou Yaohe, Numerical simulation of the convection during ACRT, Progress in Natural Science, 1997, 7(2): 215.[26

  10. Characterization of HgCdTe and Related Materials and Substrates for Third Generation Infrared Detectors

    Science.gov (United States)

    2012-12-01

    Markunas. J. D. Benson, and D. J. Smith, J. Electron. Mater. (2012). submitted. 5 J. Chai, O. C. Noriega , J. H. Dinan, and T. H. Myers, J. Electron...127 110 REFERENCES 1 J. Chai, O. C. Noriega , J. H. Dinan, and T. H. Myers, J. Electron. Mater. 41...3001(2012) 2 J. Chai, O.C. Noriega , J. H. Dinan, J. J. Kim, D. J. Smith, and T. H. Myers, J. Electron. Mater. (2012), submitted. 3 Y.-H. Zhang

  11. Promoting the demoted

    DEFF Research Database (Denmark)

    Jensen, Torben Juel; Christensen, Tanya Karoli

    2013-01-01

    In this article, we investigate a hypothesis regarding the distinction between the word orders ‘finite verb, adverb’ (V>Adv, in Scandinavian linguistics often considered an instance of V2, also in subject initial clauses) and ‘adverb, finite verb’ (Adv>V, sometimes referred to as V3) in Mainland ...

  12. 78 FR 62907 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-10-22

    ... for adding liquidity to the Exchange. Specifically, the Exchange is proposing to amend the methodology... that eliminating days where the Exchange experiences an Exchange Outage from the definition of ADV and... among Exchange constituents as the methodology for calculating ADV and TCV will apply equally to...

  13. Investigations on fungal parasites of marine algae in India: An appraisal

    Digital Repository Service at National Institute of Oceanography (India)

    Raghukumar, C.; Raghukumar, S.

    stream_size 12 stream_content_type text/plain stream_name Recent_Adv_Phycol_1994_39.pdf.txt stream_source_info Recent_Adv_Phycol_1994_39.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  14. Passive transfer of antiviral antibodies restricts replication of Aleutian mink disease parvovirus in vivo

    DEFF Research Database (Denmark)

    Alexandersen, Søren; Larsen, S; Cohn, A.;

    1989-01-01

    When mink kits were infected neonatally with a highly virulent strain of Aleutian disease virus (ADV), 100% of both Aleutian and non-Aleutian genotype mink died of interstitial pneumonia characterized by permissive ADV infection of alveolar type II cells. Treatment of infected kits with either mi...

  15. Acute interstitial pneumonia in mink kits inoculated with defined isolates of Aleutian mink disease parvovirus

    DEFF Research Database (Denmark)

    Alexandersen, Søren; Larsen, S; Aasted, B;

    1994-01-01

    The present study addressed the causal role of Aleutian mink disease parvovirus (ADV) in acute interstitial pneumonia in mink kits. All the examined isolates of ADV caused interstitial pneumonia in newborn kits, although the severity of disease and the mortality varied. These findings indicate...

  16. Deep sequencing analysis of HBV genotype shift and correlation with antiviral efficiency during adefovir dipivoxil therapy.

    Directory of Open Access Journals (Sweden)

    Yuwei Wang

    Full Text Available Viral genotype shift in chronic hepatitis B (CHB patients during antiviral therapy has been reported, but the underlying mechanism remains elusive.38 CHB patients treated with ADV for one year were selected for studying genotype shift by both deep sequencing and Sanger sequencing method.Sanger sequencing method found that 7.9% patients showed mixed genotype before ADV therapy. In contrast, all 38 patients showed mixed genotype before ADV treatment by deep sequencing. 95.5% mixed genotype rate was also obtained from additional 200 treatment-naïve CHB patients. Of the 13 patients with genotype shift, the fraction of the minor genotype in 5 patients (38% increased gradually during the course of ADV treatment. Furthermore, responses to ADV and HBeAg seroconversion were associated with the high rate of genotype shift, suggesting drug and immune pressure may be key factors to induce genotype shift. Interestingly, patients with genotype C had a significantly higher rate of genotype shift than genotype B. In genotype shift group, ADV treatment induced a marked enhancement of genotype B ratio accompanied by a reduction of genotype C ratio, suggesting genotype C may be more sensitive to ADV than genotype B. Moreover, patients with dominant genotype C may have a better therapeutic effect. Finally, genotype shifts was correlated with clinical improvement in terms of ALT.Our findings provided a rational explanation for genotype shift among ADV-treated CHB patients. The genotype and genotype shift might be associated with antiviral efficiency.

  17. Marine archaeological surveys off Tranquebar Tamilnadu coast - preliminary results

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, T.C.S.; Rao, K.M.

    stream_size 3 stream_content_type text/plain stream_name Recent_Adv_Mar_Archaeol_1991_127.pdf.txt stream_source_info Recent_Adv_Mar_Archaeol_1991_127.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  18. Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain

    Directory of Open Access Journals (Sweden)

    Shim Byoung-Shik

    2012-09-01

    Full Text Available Abstract Background Sublingual (s.l. administration of soluble protein antigens, inactivated viruses, or virus-like particles has been shown to induce broad immune responses in mucosal and extra-mucosal tissues. Recombinant replication-defective adenovirus vectors (rADVs infect mucosa surface and therefore can serve as a mucosal antigen delivery vehicle. In this study we examined whether s.l. immunization with rADV encoding spike protein (S (rADV-S of severe acute respiratory syndrome-associated coronavirus (SARS-CoV induces protective immunity against SARS-CoV and could serve as a safe mucosal route for delivery of rADV. Results Here, we show that s.l. administration of rADV-S induced serum SARS-CoV neutralizing and airway IgA antibodies in mice. These antibody responses are comparable to those induced by intranasal (i.n. administration. In addition, s.l. immunization induced antigen-specific CD8+ T cell responses in the lungs that are superior to those induced by intramuscular immunization. Importantly, unlike i.n. administration, s.l. immunization with rADV did not redirect the rADV vector to the olfactory bulb. Conclusion Our study indicates that s.l. immunization with rADV-S is safe and effective in induction of a broad spectrum of immune responses and presumably protection against infection with SARS-CoV.

  19. A novel adenovirus of Western lowland gorillas (Gorilla gorilla gorilla).

    Science.gov (United States)

    Wevers, Diana; Leendertz, Fabian H; Scuda, Nelly; Boesch, Christophe; Robbins, Martha M; Head, Josephine; Ludwig, Carsten; Kühn, Joachim; Ehlers, Bernhard

    2010-11-05

    Adenoviruses (AdV) broadly infect vertebrate hosts including a variety of primates. We identified a novel AdV in the feces of captive gorillas by isolation in cell culture, electron microscopy and PCR. From the supernatants of infected cultures we amplified DNA polymerase (DPOL), preterminal protein (pTP) and hexon gene sequences with generic pan primate AdV PCR assays. The sequences in-between were amplified by long-distance PCRs of 2-10 kb length, resulting in a final sequence of 15.6 kb. Phylogenetic analysis placed the novel gorilla AdV into a cluster of primate AdVs belonging to the species Human adenovirus B (HAdV-B). Depending on the analyzed gene, its position within the cluster was variable. To further elucidate its origin, feces samples of wild gorillas were analyzed. AdV hexon sequences were detected which are indicative for three distinct and novel gorilla HAdV-B viruses, among them a virus nearly identical to the novel AdV isolated from captive gorillas. This shows that the discovered virus is a member of a group of HAdV-B viruses that naturally infect gorillas. The mixed phylogenetic clusters of gorilla, chimpanzee, bonobo and human AdVs within the HAdV-B species indicate that host switches may have been a component of the evolution of human and non-human primate HAdV-B viruses.

  20. A novel adenovirus of Western lowland gorillas (Gorilla gorilla gorilla

    Directory of Open Access Journals (Sweden)

    Ludwig Carsten

    2010-11-01

    Full Text Available Abstract Adenoviruses (AdV broadly infect vertebrate hosts including a variety of primates. We identified a novel AdV in the feces of captive gorillas by isolation in cell culture, electron microscopy and PCR. From the supernatants of infected cultures we amplified DNA polymerase (DPOL, preterminal protein (pTP and hexon gene sequences with generic pan primate AdV PCR assays. The sequences in-between were amplified by long-distance PCRs of 2 - 10 kb length, resulting in a final sequence of 15.6 kb. Phylogenetic analysis placed the novel gorilla AdV into a cluster of primate AdVs belonging to the species Human adenovirus B (HAdV-B. Depending on the analyzed gene, its position within the cluster was variable. To further elucidate its origin, feces samples of wild gorillas were analyzed. AdV hexon sequences were detected which are indicative for three distinct and novel gorilla HAdV-B viruses, among them a virus nearly identical to the novel AdV isolated from captive gorillas. This shows that the discovered virus is a member of a group of HAdV-B viruses that naturally infect gorillas. The mixed phylogenetic clusters of gorilla, chimpanzee, bonobo and human AdVs within the HAdV-B species indicate that host switches may have been a component of the evolution of human and non-human primate HAdV-B viruses.

  1. 17 CFR 275.203-1 - Application for investment adviser registration.

    Science.gov (United States)

    2010-04-01

    ..., substantial changes to Part II of Form ADV. Thus, the rules for preparing, delivering, and offering Part II... materially inaccurate. State law may continue to require you to file Part II with the appropriate State...) When filed. Each Form ADV is considered filed with the Commission upon acceptance by the IARD....

  2. Polylysine modification of adenoviral fiber protein enhances muscle cell transduction.

    Science.gov (United States)

    Bouri, K; Feero, W G; Myerburg, M M; Wickham, T J; Kovesdi, I; Hoffman, E P; Clemens, P R

    1999-07-01

    Adenoviral vectors (ADVs) are used widely for gene delivery to different tissues including muscle. One particularly promising use for ADVs is in the transfer of the dystrophin gene to the muscle of patients with Duchenne muscular dystrophy (DMD). However, studies in different animal models of DMD suggest that ADVs inefficiently transduce mature skeletal muscle. In this article we test whether AdZ.F(pK7), a genetically modified ADV that expresses a polylysine moiety on the end of the fiber protein, could enhance transduction of muscle cells and circumvent the maturation-dependent loss of muscle infectivity by ADVs. The efficiency of transduction was tested at different levels of muscle maturation. In vitro, AdZ.F(pK7) showed a higher level of transduction at all stages of differentiation including myoblasts, myotubes, and single muscle fibers. In vivo, mature skeletal muscle was transduced fourfold better by AdZ.F(pK7) than by the unmodifled vector (AdZ.F). Together, these observations demonstrate improved ADV transduction of skeletal muscle by modifying ADV tropism, and provide a proof-of-principle that modification of ADVs to target muscle-specific molecules could result in tissue-specific transfer of skeletal muscle tissue as well.

  3. 77 FR 71461 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2012-11-30

    ... the cost of Commission rules and forms. The information provided on Form ADV-E is mandatory. Responses... Budget, Room 10102, New Executive Office Building, Washington, DC 20503 or email to: Shagufta_Ahmed@omb... Commission, c/o Remi Pavlik-Simon, 6432 General Green Way, Alexandria, VA 22312; or send an email ] to:...

  4. Topography and surface sediment distribution around Amee shoal Mormugao

    Digital Repository Service at National Institute of Oceanography (India)

    Ambre, N.V.

    stream_size 3 stream_content_type text/plain stream_name Recent_Adv_Mar_Archaeol_1991_113.pdf.txt stream_source_info Recent_Adv_Mar_Archaeol_1991_113.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  5. Relevance of topography and sediment in ship wreck exploration - Examples from Goa waters

    Digital Repository Service at National Institute of Oceanography (India)

    Pathak, M.C.; Hashimi, N.H.; Nigam, R.

    stream_size 6 stream_content_type text/plain stream_name Recent_Adv_Mar_Archaeol_1991_135.pdf.txt stream_source_info Recent_Adv_Mar_Archaeol_1991_135.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  6. Consequences of sea level rise due to greenhouse effect for coastal archaeological monuments

    Digital Repository Service at National Institute of Oceanography (India)

    Nigam, R.; Pathak, M.C.; Hashimi, N.H.

    stream_size 6 stream_content_type text/plain stream_name Recent_Adv_Mar_Archaeol_1991_116.pdf.txt stream_source_info Recent_Adv_Mar_Archaeol_1991_116.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  7. Word order variation and foregrounding of complement clauses

    DEFF Research Database (Denmark)

    Christensen, Tanya Karoli; Jensen, Torben Juel

    2015-01-01

    Through mixed models analyses of complement clauses in a corpus of spoken Danish we examine the role of sentence adverbials in relation to a word order distinction in Scandinavian signalled by the relative position of sentence adverbials and finite verb (V>Adv vs. Adv>V). The type of sentence...

  8. 78 FR 48526 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-08-08

    ... based on the SLP's level of quoting and the average daily volume (``ADV'') of liquidity added by the SLP in assigned securities, excluding early closing days for the ADV calculation. \\3\\ The SLP program provides incentives for quoting and adds competition to the existing group of liquidity providers. An...

  9. Molecular characterization, phylogeny analysis and pathogenicity of a Muscovy duck adenovirus strain isolated in China in 2014

    Science.gov (United States)

    This study aimed to characterize a novel adenovirus (AdV) isolated from diseased Muscovy ducks in China. After the AdV was successfully propagated in duck embryo fibroblasts, the morphological and physicochemical properties of the virions were studied by electron microscopy and different tests. The ...

  10. Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance

    Institute of Scientific and Technical Information of China (English)

    Yeon Seok Seo; Ji Hoon Kim; Jong Eun Yeon; Jong-Jae Park; Jae Seon Kim; Kwan Soo Byun; Young-Tae Bak; Chang Hong Lee

    2007-01-01

    AIM: To compare the antiviral efficacy of adefovir (ADV) in lamivudine (LMV)-resistant patients with LMV treatment in nucleoside-na(i)ve patients, using serum samples collected sequentially during the course of treatment progressing from LMV to ADV.METHODS: Forty-four patients with chronic hepatitis B (CHB) were included. The patients were initially treated with LMV and then switched to ADV when LMV resistance developed. Antiviral efficacy was assessed by measuring the following: reduction in serum HBV DNA from baseline, HBV DNA negative conversion (defined as HBV DNA being undectable by the hybridization assay),and HBV DNA response (either HBV DNA level ≤ 105 copies/mL or a ≥ 2 log10 reduction from baseline HBV DNA level).RESULTS: After two and six months of treatment, HBV DNA reduction was greater with LMV compared to ADV treatment (P = 0.021). HBV DNA negative conversion rates were 64% and 27% after one month of LMV and ADV treatment respectively (P = 0.001). Similarly, HBV DNA response rates were 74% and 51% after two months of LMV and ADV treatment respectively (P = 0.026).The time taken to HBV DNA negative conversion and to HBV DNA response were both delayed in ADV treatment compared with LMV.CONCLUSION: The antiviral efficacy of ADV in LMV-resistant patients is slower and less potent than that with LMV in nucleoside-na(i)ve patients during the early course of treatment.

  11. Adenovirus vectors lacking virus-associated RNA expression enhance shRNA activity to suppress hepatitis C virus replication

    Science.gov (United States)

    Pei, Zheng; Shi, Guoli; Kondo, Saki; Ito, Masahiko; Maekawa, Aya; Suzuki, Mariko; Saito, Izumu; Suzuki, Tetsuro; Kanegae, Yumi

    2013-12-01

    First-generation adenovirus vectors (FG AdVs) expressing short-hairpin RNA (shRNA) effectively downregulate the expressions of target genes. However, this vector, in fact, expresses not only the transgene product, but also virus-associated RNAs (VA RNAs) that disturb cellular RNAi machinery. We have established a production method for VA-deleted AdVs lacking expression of VA RNAs. Here, we showed that the highest shRNA activity was obtained when the shRNA was inserted not at the popularly used E1 site, but at the E4 site. We then compared the activities of shRNAs against hepatitis C virus (HCV) expressed from VA-deleted AdVs or conventional AdVs. The VA-deleted AdVs inhibited HCV production much more efficiently. Therefore, VA-deleted AdVs were more effective than the currently used AdVs for shRNA downregulation, probably because of the lack of competition between VA RNAs and the shRNAs. These VA-deleted AdVs might enable more effective gene therapies for chronic hepatitis C.

  12. The impact of developmental activities on the coastal environment and ecology in Goa - Case study

    Digital Repository Service at National Institute of Oceanography (India)

    Sawkar, K.

    stream_size 11 stream_content_type text/plain stream_name Adv_Int_Trg_Prog_CMEPP-98_1998_10pp.pdf.txt stream_source_info Adv_Int_Trg_Prog_CMEPP-98_1998_10pp.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset...

  13. Complete genome sequence and integrated protein localization and interaction map for alfalfa dwarf virus, which combines properties of both cytoplasmic and nuclear plant rhabdoviruses

    Energy Technology Data Exchange (ETDEWEB)

    Bejerman, Nicolás, E-mail: n.bejerman@uq.edu.au [Instituto de Patología Vegetal (IPAVE), Centro de Investigaciones Agropecuarias (CIAP), Instituto Nacional de Tecnología Agropecuaria INTA, Camino a 60 Cuadras k 5,5, Córdoba X5020ICA (Argentina); Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, QLD 4072 (Australia); Giolitti, Fabián; Breuil, Soledad de; Trucco, Verónica; Nome, Claudia; Lenardon, Sergio [Instituto de Patología Vegetal (IPAVE), Centro de Investigaciones Agropecuarias (CIAP), Instituto Nacional de Tecnología Agropecuaria INTA, Camino a 60 Cuadras k 5,5, Córdoba X5020ICA (Argentina); Dietzgen, Ralf G. [Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, QLD 4072 (Australia)

    2015-09-15

    Summary: We have determined the full-length 14,491-nucleotide genome sequence of a new plant rhabdovirus, alfalfa dwarf virus (ADV). Seven open reading frames (ORFs) were identified in the antigenomic orientation of the negative-sense, single-stranded viral RNA, in the order 3′-N-P-P3-M-G-P6-L-5′. The ORFs are separated by conserved intergenic regions and the genome coding region is flanked by complementary 3′ leader and 5′ trailer sequences. Phylogenetic analysis of the nucleoprotein amino acid sequence indicated that this alfalfa-infecting rhabdovirus is related to viruses in the genus Cytorhabdovirus. When transiently expressed as GFP fusions in Nicotiana benthamiana leaves, most ADV proteins accumulated in the cell periphery, but unexpectedly P protein was localized exclusively in the nucleus. ADV P protein was shown to have a homotypic, and heterotypic nuclear interactions with N, P3 and M proteins by bimolecular fluorescence complementation. ADV appears unique in that it combines properties of both cytoplasmic and nuclear plant rhabdoviruses. - Highlights: • The complete genome of alfalfa dwarf virus is obtained. • An integrated localization and interaction map for ADV is determined. • ADV has a genome sequence similarity and evolutionary links with cytorhabdoviruses. • ADV protein localization and interaction data show an association with the nucleus. • ADV combines properties of both cytoplasmic and nuclear plant rhabdoviruses.

  14. Effects of Levels of Automation for Advanced Small Modular Reactors: Impacts on Performance, Workload, and Situation Awareness

    Energy Technology Data Exchange (ETDEWEB)

    Johanna Oxstrand; Katya Le Blanc

    2014-07-01

    The Human-Automation Collaboration (HAC) research effort is a part of the Department of Energy (DOE) sponsored Advanced Small Modular Reactor (AdvSMR) program conducted at Idaho National Laboratory (INL). The DOE AdvSMR program focuses on plant design and management, reduction of capital costs as well as plant operations and maintenance costs (O&M), and factory production costs benefits.

  15. Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy

    Institute of Scientific and Technical Information of China (English)

    Xing-guo ZHANG; Jing MIAO; Min-wei LI; Sai-ping JIANG; Fu-qiang HU; Yong-zhong DU

    2008-01-01

    Herein, solid lipid nanoparticles (SLN) were proposed as a new drug delivery system for adefovir dipivoxil (ADV). The octadecylamine-fluorescein isothiocynate (ODA-FITC) was synthesized and used as a fluorescence maker to be incorporated into SLN to investigate the time-dependent cellular uptake of SLN by HepG2.2.15. The SLN of monostearin with ODA-FITC or ADV were prepared by solvent diffusion method in an aqueous system. About 15wt% drug entrapment efficiency (EE) and 3wt% drug loading (DL) could be reached in SLN loading ADV. Comparing with free ADV, the inhibitory effects of ADV loaded in SLN on hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA levels in vitro were significantly enhanced.

  16. Draft Function Allocation Framework and Preliminary Technical Basis for Advanced SMR Concepts of Operations

    Energy Technology Data Exchange (ETDEWEB)

    Jacques Hugo; John Forester; David Gertman; Jeffrey Joe; Heather Medema; Julius Persensky; April Whaley

    2013-08-01

    This report presents preliminary research results from the investigation into the development of new models and guidance for Concepts of Operations in advanced small modular reactor (AdvSMR) designs. AdvSMRs are nuclear power plants (NPPs), but unlike conventional large NPPs that are constructed on site, AdvSMRs systems and components will be fabricated in a factory and then assembled on site. AdvSMRs will also use advanced digital instrumentation and control systems, and make greater use of automation. Some AdvSMR designs also propose to be operated in a multi-unit configuration with a single central control room as a way to be more cost-competitive with existing NPPs. These differences from conventional NPPs not only pose technical and operational challenges, but they will undoubtedly also have regulatory compliance implications, especially with respect to staffing requirements and safety standards.

  17. 电刺激大鼠上矢状窦区硬脑膜后血浆与脑组织中降钙素基因相关肽、P物质和前列腺素 E2释放差异%Release difference of calcitonin gene-related peptide,substance P and prostaglandin E2 in orbital venous plexus plasma and brain tissues from rats with dura mater of superior sagittal sinus following electrical stimulation

    Institute of Scientific and Technical Information of China (English)

    陈健; 吕新勇; 孙晓萍; 陈春苗; 周军; 王振中; 萧伟

    2014-01-01

    OBJECTIVE Toexplorethefeasibilityofpreparingamigrainemodelusingratdura materofsuperiorsagittalsinusinfollowingelectricalstimulation.METHODS MaleSDratswereexposed to 1 h electrical stimulation after brain electrode implantation,at 3 V,6 Hz,and a pulse of 0.25 ms.At 0, 1 5,30 min,and 1 h,orbital blood and brain tissue were taken.The content of calcitonin gene-related peptide (CGRP),substance P and prostaglandin E2 (PGE2 )in the plas ma and brain tissue was detec-tedbyradioimmunoassay.RESULTS ThebraintissuecontentofCGRP,substancePandPGE2in the sham group and normal group was not significantly different.CGRP,substance P and PGE2 in brain tissue of model group were 3.41 ±0.93,1 .80 ±0.64,3.41 ±0.93 and (1 .80 ±0.64)ng·g -1 respec-tively,significantly different from sham group(P<0.05).At different time points,the content of CGRP, substance P and PGE2 in plasma orbital venous plexus showed no significant difference between sham groupandmodelgroup.CONCLUSION ThereleaseofCGRP,PGE2andsubstancePinbraintissue is significantly different fro m that of plas ma after electrical sti mulation.The results suggest that a model of migraine can be constructed by electrical stimulation.%目的:探讨电刺激大鼠上矢状窦区硬脑膜制备偏头痛模型的可行性。方法雄性SD 大鼠,脑部电极植入术后行电压3 V、频率6 Hz、脉宽0.25 ms、时间1 h电刺激,并于刺激0,15和30 min和1 h进行眼眶采血,采血后取脑组织。采用放射免疫法检测血浆和脑组织中降钙素基因相关肽(CGRP)、P物质和前列腺素E2(PGE2)含量。结果手术对照组与正常对照组大鼠脑组织中 CGRP 含量、P 物质含量和PGE2含量为均无显著性差异;模型组大鼠脑组织中CGRP、P物质和 PGE2分别为3.41±0.93,1.80±0.64和(5.17±0.69)ng·g -1,与手术对照组大鼠相比均有显著性差异(P<0.05)。各时间点手术对照组与模型组大鼠外周静脉血浆中CGRP、P物质和PGE2含量无显著性差异。结论电刺激大鼠上矢状窦区硬脑膜后,脑组织中CGRP、PGE2和P物质水平与外周静脉血中显著不同,表明可采用本方法制备偏头痛模型。

  18. Degradação da matéria seca e da proteína bruta de silagens de milho sem espigas com cana-de-açúcar e bagaço de mandioca - DOI: 10.4025/actascianimsci.v28i4.605 Dry mater and crude protein ruminal degradation of corn silage without spikes with sugar cane and manioc pulp - DOI: 10.4025/actascianimsci.v28i4.605

    Directory of Open Access Journals (Sweden)

    Paulo Rossi Junior

    2006-02-01

    Full Text Available A degradação ruminal da matéria seca (MS e da proteína bruta (PB de silagen s de milho sem espigas (SMSE com cana -de-açúcar (CA e bagaço seco de mandioca (BSM, comparadas com a silagem de milho com espigas (SMCE, foi avaliada. A ensilagem foi feita com (CI e sem inoculante (SI - Lactobacillus plantarum e L paracasei ssp. paracasei. Estudaram-se: as frações solúvel (A, potencialmente degradável (B e não degradável (C; a taxa de degradação da fração B (c; a degradabilidade efetiva (DE e potencial (DP, para os tratamentos: T1 (SMSE+20% CA -SI; T2 (SMSE+20% CA -CI; T3 (SMSE+35% CASI; T4 (SMSE+35% CA-CI; T5 (SMSE+20% BSM-SI; T6 (SMSE+20% BSM-CI; T7 (SMSE+35% BSM-SI; T8 (SMSE+35% BSM-CI; T9 (SMCE-SI e T10 (SMCE-CI. As médias foram comparadas num delineamento inteiramente casualisado. Houve diferença (P0,05. A adição de BSM (20 e 35% às SMSE aumentou (PThe goal of this work was to evaluate the ruminal degradation of corn silages without spikes (CSWS, added with sugar cane (SC and dry manioc pulp (DMP, as compared as corn silage (CS. The foods were ensiled with (WI and without (IF inoculant’s, composed by Lactobacillus plantarum and L. paracasei ssp. paracasei. The following fractions have been studied: water soluble (A, potentially degradable (B, non degradable (C, fraction B degradable ratio (c; effective (ED and potential (PD degradability. The treatments evaluated were: T1 (CSWS + 20% SC -IF; T2 (CSWS + 20% SC-WI; T3 (CSWS + 35% SC -IF; T4 (CSWS + 35% SC -WI; T5 (CSWS + 20% DMP-IF; T6 (CSWS + 20% DMP -WI; T7 (CSWS + 35% DMP -IF; T8 (CSWS + 35% DMP-WI; T9 (CS-WI and T10 (CS-IF. The average differences have been compared on a completely randomized model. Difference (P 0.05 for all treatments. Dry manioc pulp added to the non spikes corn silage (20 and 35% - DM basis, has allowed the rise of the DM fraction B, indicating the possibility to add up to 35% of dry manioc pulp on corn silage, inst ead of green spikes.

  19. Rare Earth Ion-Host Lattice Interactions 14. Lanthanide Pentaphosphates

    Science.gov (United States)

    1977-02-01

    468. 5K.-R. Albrand , R. Attig, J. Fenner, J. P. Jeser, and D. Mootz, Mater. Res. Bull., 9 (1974), 129. H ’= I B, C , k = 2, 4, 6 , (1...H. Y-P Hong, Acta Crystallogr., B30 (1974), 468. (5) K.-R. Albrand , R. Attig, J. Fenner, J. P. Jeser, and D. Mootz, Mater. Res. Bull., 9_ (1974

  20. Molecular Engineering for Mechanically Resilient and Stretchable Electronic Polymers and Composites

    Science.gov (United States)

    2016-06-08

    determine molecular design rules for maximizing electronic performance with good mechanical deformability ( Roth et al. Chem. Mater. 2016, 28, 2363...efficient and mechanically stable. This paragraph was adapted from our paper Roth et al. Chem. Mater. 2016, 28, 2363-2373. Figure 2. Schematic...bandgap semiconducting polymers to determine molecular design rules for maximizing electronic performance with good mechanical deformability ( Roth et

  1. Characterization of opaques off Konkan Coast Maharashtra, central west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Gujar, A.R.; Angusamy, N.; Rajamanickam, G. V.

    stream_size 26526 stream_content_type text/plain stream_name J_Miner_Mater_Character_Eng_6_53.pdf.txt stream_source_info J_Miner_Mater_Character_Eng_6_53.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset...

  2. Microstructural Evolution in Laser Deposited Nickel-Titanium-Carbon in Situ Metal-Matrix Composites (Preprint)

    Science.gov (United States)

    2010-01-01

    investigated Ni-TiC composites processed by direct laser fabrication (DLF) from a feedstock of elemental nickel and titanium carbide powders. They focused... laser fabrication using powder and wire. Mater Design 2007; 28:2040-6. 3. Y. Choi, J. K. Lee, M. E. Mullins, J. Mater. Sci 32(1997) 1717-1724. 4

  3. 75 FR 51823 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2010-08-23

    ... protein (EGFP) gene downstream of the promoter. Excision of the EGFP gene by Cre recombinase allows... mouse model, designated 1\\glo\\, which permits conditional, gene-specific overexpression of TGF- 1. The... Human Recombinant MATER Protein Description of Technology: The inventors have identified MATER, a...

  4. Microstructure and Mechanical Properties of Bulk Nanostructured Cu-Ta Alloys Consolidated by Equal Channel Angular Extrusion

    Science.gov (United States)

    2014-07-01

    Averback RS, King WP. Scr Mater 2012;67:720. [2] Vo NQ, Chee SW, Schwen D, Zhang XA, Bellon P, Averback RS. Scr Mater 2010;63:929. [3] Zhang X, Wen JG...Cambridge University Press; 2007. [37] Li JCM. Mechanical properties of nanocrystalline materials. Singa- pore : Pan Stanford Publishing; 2011. [38] Wei QM

  5. Synthetic Multi-Functional Materials for Structural + Ballistic and Blast Protection

    Science.gov (United States)

    2005-03-01

    Meyers, M.A. Meyers, and K.S. Vecchio, "Quasi-Static and dynamic mechanical response of Strombus gigas (conch) shells", Mater. Sci. & Eng., A297 (2001...Mater. Sci. & Eng., 2001. A297 : p. 203-211. 28. Menig, R., M.H. Meyers, M.A. Meyers and K.S. Vecchio, Quasi-static and Dynamic mechanical response

  6. Critical Percolation Stresses of Random Frank-Read Sources in Micron-Sized Crystals of Superalloys (Preprint)

    Science.gov (United States)

    2011-11-01

    tendency for a saturation stress value, most likely because the experimental size-effect data does not include small enough sizes of micron-sized crystals...D, Gumbsch P, Kraft O, Scripta Mater 2008; 58:587. 7) Tang H, Schwarz KW, Espinosa HD, Acta Mater 2007; 55:1607. 8) Zhou C, Biner S, Lesar R

  7. Critical Percolation Stresses of Random Frank-Read Sources in Micrometer-Sized Crystals of Superalloys (Postprint)

    Science.gov (United States)

    2012-07-09

    controls the yield stress [20]. However, the experimental data [4] do not show any such tendency for a saturation stress value, most likely because the...D M, Parthasarathy T A, Uchic M D, Tang M and Woodward C 2008 Acta Mater. 56 3245 [6] Senger J, Weygand D, Gumbsch P and Kraft O 2008 Scr. Mater. 58

  8. Improvement of Thermoelectric-Properties for Mg-Based Quaternary Compounds With Doping via Bulk Mechanical Alloying

    Science.gov (United States)

    2010-02-05

    2000) 17-27. 4) Y. Noda, N. Otsuka , K. Masumoto and I.A. Nishida: J. Appl. Phys. 53 (1989) 487-491. 5) Y. Noda, H. Kon, Y. Fushitaka, N. Otsuka , I...Nishida and K. Masumoto: Mater. Trans. JIM 53 (1992) 844-850. 6) Y. Noda, H. Kon, Y. Fushitaka, N. Otsuka , I. Nishida and K. Masumoto: Mater. Trans

  9. Single-strand conformation polymorphism analysis for the study of adenoviral diversity in urban rivers.

    Science.gov (United States)

    Lee, Cheonghoon; Kim, Sang-Jong

    2010-05-01

    The diversity of human adenoviruses (AdVs) in river waters was studied by single-strand conformational polymorphism (SSCP) analysis. Water samples were collected between 2002 and 2003 from 4 rivers in the Gyeonggi Province, South Korea. Forty-six (79.3%) of the 58 samples were positive for AdVs as determined on PCR amplification. Nine different SSCP profiles (profiles A to I) were detected in all the AdVs-positive samples by SSCP analysis, and most of the AdVs-positive samples (38 of 46 samples; 82.6%) showed the SSCP profile D. Nine different sequences were obtained in the SSCP profiles; sequence alignments and phylogenetic analysis identified 5 different sequences that were closely related to the human AdV type 41, and the 4 different sequences that were closely related to human AdV types 3, 4, 12, and 40. Two AdVs genomic variants were detected (types 3 and 41 in A, types 12 and 41 in B, and 2 genomic variants of type 41 in C) in SSCP profiles A, B, and C, respectively. SSCP analysis could be a useful technique for the identification of genetic variants of AdVs and for studying AdVs diversity in urban rivers.

  10. Acoustic Droplet Vaporization in Biology and Medicine

    Directory of Open Access Journals (Sweden)

    Chung-Yin Lin

    2013-01-01

    Full Text Available This paper reviews the literature regarding the use of acoustic droplet vaporization (ADV in clinical applications of imaging, embolic therapy, and therapeutic delivery. ADV is a physical process in which the pressure waves of ultrasound induce a phase transition that causes superheated liquid nanodroplets to form gas bubbles. The bubbles provide ultrasonic imaging contrast and other functions. ADV of perfluoropentane was used extensively in imaging for preclinical trials in the 1990s, but its use declined rapidly with the advent of other imaging agents. In the last decade, ADV was proposed and explored for embolic occlusion therapy, drug delivery, aberration correction, and high intensity focused ultrasound (HIFU sensitization. Vessel occlusion via ADV has been explored in rodents and dogs and may be approaching clinical use. ADV for drug delivery is still in preclinical stages with initial applications to treat tumors in mice. Other techniques are still in preclinical studies but have potential for clinical use in specialty applications. Overall, ADV has a bright future in clinical application because the small size of nanodroplets greatly reduces the rate of clearance compared to larger contrast agent bubbles and yet provides the advantages of ultrasonographic contrast, acoustic cavitation, and nontoxicity of conventional perfluorocarbon contrast agent bubbles.

  11. Components of Adenovirus Genome Packaging

    Science.gov (United States)

    Ahi, Yadvinder S.; Mittal, Suresh K.

    2016-01-01

    Adenoviruses (AdVs) are icosahedral viruses with double-stranded DNA (dsDNA) genomes. Genome packaging in AdV is thought to be similar to that seen in dsDNA containing icosahedral bacteriophages and herpesviruses. Specific recognition of the AdV genome is mediated by a packaging domain located close to the left end of the viral genome and is mediated by the viral packaging machinery. Our understanding of the role of various components of the viral packaging machinery in AdV genome packaging has greatly advanced in recent years. Characterization of empty capsids assembled in the absence of one or more components involved in packaging, identification of the unique vertex, and demonstration of the role of IVa2, the putative packaging ATPase, in genome packaging have provided compelling evidence that AdVs follow a sequential assembly pathway. This review provides a detailed discussion on the functions of the various viral and cellular factors involved in AdV genome packaging. We conclude by briefly discussing the roles of the empty capsids, assembly intermediates, scaffolding proteins, portal vertex and DNA encapsidating enzymes in AdV assembly and packaging. PMID:27721809

  12. Task-dependent modulation of primary afferent depolarization in cervical spinal cord of monkeys performing an instructed delay task.

    Science.gov (United States)

    Seki, Kazuhiko; Perlmutter, Steve I; Fetz, Eberhard E

    2009-07-01

    Task-dependent modulation of primary afferent depolarization (PAD) was studied in the cervical spinal cord of two monkeys performing a wrist flexion and extension task with an instructed delay period. We implanted two nerve cuff electrodes on proximal and distal parts of the superficial radial nerve (SR) and a recording chamber over a hemi-laminectomy in the lower cervical vertebrae. Antidromic volleys (ADVs) in the SR were evoked by intraspinal microstimuli (ISMS, 3-10 Hz, 3-30 microA) applied through a tungsten microelectrode, and the area of each ADV was measured. In total, 434 ADVs were evoked by ISMS in two monkeys, with onset latency consistently shorter in the proximal than distal cuffs. Estimated conduction velocity suggest that most ADVs were caused by action potentials in cutaneous fibers originating from low-threshold tactile receptors. Modulation of the size of ADVs as a function of the task was examined in 281 ADVs induced by ISMS applied at 78 different intraspinal sites. The ADVs were significantly facilitated during active movement in both flexion and extension (Pmodulation of PAD. This facilitation started 400-900 ms before the onset of EMG activity. Such pre-EMG modulation is hard to explain by movement-induced reafference and probably is associated with descending motor commands.

  13. Wild boar: an increasing concern for Aujeszky's disease control in pigs?

    Directory of Open Access Journals (Sweden)

    Boadella Mariana

    2012-01-01

    Full Text Available Abstract Background The goal of this study was describing the temporal evolution of Aujeszky's disease virus (ADV contact prevalence among Eurasian wild boar (Sus scrofa populations under different management regimes and contact likelihoods with domestic pigs. Given the recent increase in wild boar abundance throughout Europe, we hypothesized that wild boar contact with ADV would remain stable in time even after significant reduction of ADV prevalence in domestic pigs. Results Sera from 1659 wild boar were collected from 2000 to 2010 within 6 areas of the Iberian Peninsula and tested for the presence of antibodies against ADV by ELISA. According to sampling date, wild boar were grouped into three time periods. ADV prevalence was compared through period both globally and by geographic area. Overall seroprevalence for the ten-year study period was 49.6 ± 2.4%. The highest seroprevalence was recorded in areas with intense wild boar management. The annual proportion of positive wild boar sampling sites remained stable through the study period, while the percentage of domestic pig AD positive counties decreased from 70% in 2003 to 1.7% in 2010. Conclusions Results presented herein confirmed our hypothesis that ADV would remain almost stable in wild boar populations. This evidences the increasing risk wild boar pose in the final stages of ADV eradication in pigs and for wildlife conservation.

  14. Low-Dose Adefovir-Induced Hypophosphatemic Osteomalacia on Whole-Body Bone Scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Hoon; Won, Kyoung Sook; Song, Bongil; Jo, Il; Zeon, Seok Kil [Keimyung Univ., Daegu (Korea, Republic of)

    2013-12-15

    While adefovir dipivoxil (ADV) effectively suppresses the hepatitis B virus, it can cause proximal renal tubular dysfunction leading to phosphate wasting. The safety of low-dose ADV (a dose of 10 mg/day), which does not induce clinically significant nephrotoxicity, is well recognized, but a few cases of hypophosphatemic osteomalacia (HO) caused by low-dose ADV therapy have recently been reported. Although HO induced by low-dose ADV therapy is rare, the presence of bone pain in patients treated with ADV should be monitored. Bone scintigraphy can be performed to confirm the occurrence of osteomalacia and to determine the disease extent. Bone scintigraphic and radiological image findings with a brief review of the literature are presented in this article. We report two cases of HO induced by low-dose ADV therapy that showed multifocal increased radiotracer uptakes in the bilateral bony ribs, spines, pelvic bones and lower extremities on whole-body bone scintigraphy. Bone pain gradually improved after phosphate supplementation and by changing the antiviral agent. Whole-body bone scintigraphy is a highly sensitive imaging tool and can show disease extent at once in the setting of the wide range of the clinical spectrum with nonspecific radiological findings. Furthermore, frequent involvement of the lower extremities, as a result of maximum weight bearing, could be an additional scintigraphic clue for the diagnosis of HO. These cases could be helpful for both clinicians prescribing ADV and nuclear physicians to prevent delayed diagnosis and plan further appropriate treatment.

  15. Enfermedad neurologica por adenovirus Neurologic disease due to adenovirus infection

    Directory of Open Access Journals (Sweden)

    Cristina L. Lema

    2005-06-01

    Full Text Available El objetivo de este trabajo fue determinar la prevalencia de adenovirus (ADV en las infecciones del sistema nervioso central (SNC. Se analizaron 108 muestras de líquido cefalorraquídeo (LCR provenientes de 79 casos de encefalitis, 7 meningitis y 22 de otras patologías neurológicas, recibidas en el período 2000-2002. Cuarenta y nueve (47.35% se obtuvieron de pacientes inmunocomprometidos. La presencia de ADV se investigó mediante reacción en cadena de la polimerasa en formato anidado (Nested-PCR. La identificación del genogrupo se realizó mediante análisis filogenético de la secuencia nucleotídica parcial de la región que codifica para la proteína del hexón. Se detectó la presencia de ADV en 6 de 108 (5.5% muestras de LCR analizadas. Todos los casos positivos pertenecieron a pacientes con encefalitis que fueron 79, (6/79, 7.6%. No se observó diferencia estadísticamente significativa entre los casos de infección por ADV en pacientes inmunocomprometidos e inmunocompetentes (p>0.05. Las cepas de ADV detectadas se agruparon en los genogrupos B1 y C. En conclusión, nuestros resultados describen el rol de los ADV en las infecciones neurológicas en Argentina. La información presentada contribuye al conocimiento de su epidemiología, en particular en casos de encefalitis.The aim of this study was to assess the prevalence of adenovirusm (ADV infections in neurological disorders. A total of 108 cerebrospinal fluid (CSF samples from 79 encephalitis cases, 7 meningitis and 22 other neurological diseases analysed in our laboratory between 2000 and 2002 were studied. Forty nine (47.4% belonged to immunocompromised patients. Viral genome was detected using nested polymerase chain reaction (Nested-PCR and ADV genotypes were identified using partial gene sequence analysis of hexon gene. Adenovirus were detected in 6 of 108 (5.5% CSF samples tested. All of these were from encephalitis cases, 6/79, representing 7.6% of them. No statistically

  16. Fanconi syndrome due to prolonged use of low-dose adefovir

    Directory of Open Access Journals (Sweden)

    Xiao-Bing Wang

    2015-01-01

    Full Text Available Fanconi syndrome results from a generalized abnormality of the proximal tubules of the kidney and owing to phosphate depletion can cause hypophosphatemic osteomalacia. Adefovir dipivoxyl (ADV effectively suppresses hepatitis B virus replication but exhibits nephrotoxicity when administered at a low dosage. We report two cases of Fanconi syndrome induced by ADV at 10 mg/day to call for regular screening for evidence of proximal tubular dysfunction and detailed bone metabolic investigations for prompt detection of ADV nephrotoxicity is critically important to ensure timely drug withdrawal before the development of irreversible tubulointerstitial injury.

  17. Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment

    Institute of Scientific and Technical Information of China (English)

    Soon Young Ko; Byung Kook Kim; So Young Kwon; Kyun-Hwan Kim; Jeong Han Kim; Won Hyeok Choe; Chang HongLee

    2012-01-01

    AIM:To identify hepatitis B virus polymerase gene mutations during antiviral therapy using lamivudineadefovir sequential monotherapy followed by lamivudine-adefovir combination therapy.METHODS:The patient cohort included four adult chronic hepatitis B patients who had undergone sequential monotherapy,first with lamivudine (LMV)and then,after developing viral breakthrough,with adefovir (ADV) therapy.All of the patients had non-response or viral breakthrough after LMV-ADV sequential monotherapy,which resulted in the switching of their antiviral regimen to LMV-ADV combination therapy.Eleven serum samples from the four patients who showed non-response to rescue LMV-ADV combination therapy were collected sequentially at a time before the antiviral treatment and then during the LMV monotherapy,ADV monotherapy,and LMV-ADV combination therapy.For the genotypic analysis,the whole 1310-bp polymerase gene region was amplified,cloned and sequenced.RESULTS:All patients had been previously treated with 100 mg of LMV once daily for a 15-to 26-mo period.The emergence of resistance mutations to LMV,such as rtM204V/I and/or rtL180M,were found in all patients.Their antiviral regimens were switched to ADV monotherapy as the second line treatment.All patients had viral breakthrough or non-response after the LMV-ADV sequential monotherapy.ADV-resistant mutations were detected after 13 to 19 mo of LMV-ADV sequential monotherapy.The rtA181V/T mutations were predominantly identified during the ADV treatment in the LMV-resistant patients.Twenty-seven of 38 clones were combined with an amino acid change at rt181;three clones had mutations in rt236 and one clone had a combined mutation.The rtA181V/T mutations were not suppressed by the LMV-ADV combination therapy.Thirty-nine of 64 clones showed an rtA181V/T mutation and six clones showed combined mutations in rt181 and rt236.Mutations in rt204 re-emerged during the combination treatment.The rt181 and rt204 mutations did not co-exist in one

  18. SYNERGISTIC EFFICACY OF ADENOVIRUS-MEDIATED BCL-XS GENE TRANSFER AND TOPOTECAN IN OVARIAN CANCER CELL

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To observe the synergistic efficacy between Adenovirus-mediated bcl-Xs(Adv-bcl-Xs) gene transfer and chemotherapy on ovarian cancer cell growth. Methods: NuTu-19 cells were infected by different titers of Adv-bcl-Xs and treated with topotecan in the meantime. Cell proliferation was measured 3 days later by MTT. Graphical representations and statistical analyses for their interaction in tumor cells were done. Results: The statistical result and Graphical representations of the statistical modeling showed synergy effect on cell growth inhibition (P<0.01). Conclusion: There were synergistic efficacies between Adv-bcl-Xs gene therapy and Topotecan in ovarian cancer cell growth.

  19. Subcellular localization of Aleutian mink disease parvovirus proteins and DNA during permissive infection of Crandell feline kidney cells

    DEFF Research Database (Denmark)

    Oleksiewicz, M.B.; Costello, F.; Huhtanen, M.

    1996-01-01

    Confocal microscopy allowed us to localize viral nonstructural (NS) and capsid (VP) proteins and DNA simultaneously in cells permissively infected with Aleutian mink disease parvovirus (ADV). Early after infection, NS proteins colocalized with viral DNA to form intranuclear inclusions, whereas VP...... proteins formed hollow intranuclear shells around the inclusions. Later, nuclei had irregular outlines and were virtually free of ADV products. In these cells, inclusions of viral DNA with or without associated NS protein were embedded in cytoplasmic VP protein. These findings implied that ADV replication...

  20. Assessment of the Navy’s North West Region Advance Food Menu Gallery Workload and Food Cost Impact Trade-Offs

    Science.gov (United States)

    2009-06-01

    scratch. Prepared from frozen raw chicken, frozen vegetables, and dry pasta. L P00701 Minestrone (Fz) Adv Frozen boil in bag product L Q10500 Broccoli ... Broccoli Soup Adv Pre-made frozen boil in bag product D P02300 Split Pea Soup Adv Pre-made frozen boil in bag product . D E00800 Rice Pilaf SpScr...oven baked D Q10500 Broccoli (Fz) SpScr From frozen product -cook/serve D Q11000 Corn Whole Kernel (Fz) SpScr From frozen product -cook/serve Table A4

  1. Body-selective areas in the visual cortex are less active in children than in adults

    OpenAIRE

    Paddy D Ross; de Gelder, Beatrice; Crabbe, Frances; Grosbras, Marie-Helene

    2014-01-01

    Our ability to read other people’s non-verbal signals gets refined throughout childhood and adolescence. How this is paralleled by brain development has been investigated mainly with regards to face perception, showing a protracted functional development of the face-selective visual cortical areas. In view of the importance of whole-body expressions in interpersonal communication it is important to understand the development of brain areas sensitive to these social signals. Here we used funct...

  2. Introducing Viewpoints of Mechanics into Basic Growth Analysis-(XIII) : Comparing Growth Mechanics between Logistic Functions and Basic Growth Functions-

    OpenAIRE

    Shimojo, Masataka; Shao, Tao; Ishimatsu, Satoshi; Tanoue, Jun; Kakihara, Hidetoshi; Sata, Chiemi; Fukudome, Hayato; Ishiwaka, Reiko; Asano, Yoki; Nakano, Yutaka; Tobisa, Manabu; Masuda, Yasuhisa

    2009-01-01

    This study was conducted to compare growth mechanics between logistic functions and basic growth functions. The results obtained were as follows. Differential equation for basic growth function showed that the square of growth rate was described using the product of weight and growth acceleration. This form was similar to Newton's law of motion where differential of momentum is described using the product of mass of an object and acceleration. However, differential equation for logistic funct...

  3. A Ticking Time Bomb: Counterterrorism Lessons From the U.S. Government’s Failure to Prevent the Fort Hood Attack

    Science.gov (United States)

    2011-02-03

    ion. They perfonn critica ll y important homeland security funct ions and have produced numerous successes in disrupting and apprehending potential...Radicalizafion in the Wesl: The Homegrown Threat (2007). 17 experience a crisis or have a gri evance - whether social, economic, political, or...he was engaged in overt terrorist activity, (3) analyze Hasan’s communications more critica ll y as to whether they were truly research , and (4

  4. Intranet 2.0: Fostering Collaboration

    OpenAIRE

    Engard, Nicole C.; Park, Rayana Min

    2006-01-01

    This article discusses the development of the Jenkins Law Library Intranet 2.0. The updated intranet consists of a wide range of warm colors and 3-D images for depth and an inviting look. Task-related tabs, which are the main navigation system for the intranet, are used to move away from organizing data based on departments and toward fostering collaboration among all areas of the library. Also, symbols remain constant throughout the site, making the correlation between illustration and funct...

  5. Genetic programming theory and practice XII

    CERN Document Server

    Riolo, Rick; Kotanchek, Mark

    2015-01-01

    These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics in this volume include: gene expression regulation, novel genetic models for glaucoma, inheritable epigenetics, combinators in genetic programming, sequential symbolic regression, system dynamics, sliding window symbolic regression, large feature problems, alignment in the error space, HUMIE winners, Boolean multiplexer funct

  6. Differential evolutionary algorithm for distribution capacitor allocation considering varying load conditions

    OpenAIRE

    Karimi, Mohammad

    2011-01-01

    Many loads in power systems are inductive loads then consume reactive power, this fact lead to drop voltage and in worst case blackout and collapse voltage. Best option in distribution networks for avoid of this problem is installation of capacitor bank. In capacitor installation, finding optimal location and size of capacitor have special importance. In this paper, Differential Evolutionary (DE) algorithm is proposed for optimal placement and sizing of capacitor. Our objective funct...

  7. Entangled photon pairs from a quantum dot cascade decay: the effect of time-reordering

    OpenAIRE

    F. Troiani; Tejedor, C.

    2008-01-01

    Coulomb interactions between confined carriers remove degeneracies in the excitation spectra of quantum dots. This provides a which path information in the cascade decay of biexcitons, thus spoiling the energy-polarization entanglement of the emitted photon pairs. We theoretically analyze a strategy of color coincidence across generation (AG), recently proposed as an alternative to the previous, within generation (WG) approach. We simulate the system dynamics and compute the correlation funct...

  8. Analysis of Bilingual Children’s Performance on the English and Spanish Versions of the Woodcock-Muñoz Language Survey-R (WMLS-R)

    OpenAIRE

    2015-01-01

    The purpose of this study was to investigate the way in which items on the Woodcock-Muñoz Language Survey Revised (WMLS-R) Spanish and English versions function for bilingual children from different ethnic subgroups who speak different dialects of Spanish. Using data from a sample of 324 bilingual Hispanic families and their children living on the United States mainland, differential item functioning (DIF) was conducted to determine if test items in English and Spanish funct...

  9. Effects of land-use activities in the Ayuquila river´s fauna

    OpenAIRE

    Palomera-Garcia, Carlos

    2012-01-01

    Land use change is an important human force causing modifications in the structure and quality of freshwater ecosystems worldwide. Multiple stressors have affected the Ayuquila-Armeria River in Jalisco, the third largest rivers and second in biodiversity in that Mexican state. Despite an on-going monitoring program focused on water quality, no evidence exists on how land use activities have affected its aquatic communities. I characterized the invertebrate and fish communities using the funct...

  10. Osteoblast Differentiation and Bone: Relevant proteins, regulatory processes and the vascular connection

    OpenAIRE

    2012-01-01

    textabstractBone is a highly specialized form of connective tissue present in most vertebrate animals as part of the endoskeleton. Structurally speaking, bone is mainly constituted by an organic extracellular matrix (ECM) hardened by deposited mineral. The blending between the organic and inorganic parts originates two main types of osseous tissue. The outer part of the tissue, the cortex, is hard compact bone and surrounds the inner trabecular bone, a spongy-like structure. In terms of funct...

  11. Third Order Trace Formula

    Indian Academy of Sciences (India)

    Arup Chattopadhyay; Kalyan B Sinha

    2013-11-01

    In J. Funct. Anal. 257 (2009) 1092–1132, Dykema and Skripka showed the existence of higher order spectral shift functions when the unperturbed self-adjoint operator is bounded and the perturbation is Hilbert–Schmidt. In this article, we give a different proof for the existence of spectral shift function for the third order when the unperturbed operator is self-adjoint (bounded or unbounded, but bounded below).

  12. Striving for a balance: Nature, power, science and India′s Indira Gandhi, 1917-1984

    OpenAIRE

    Rangarajan Mahesh

    2009-01-01

    Indira Gandhi′s life (1917-1984) spanned much of the twentieth century. She was Prime Minister of the world′s largest democracy for two spells that totaled fifteen years. To this day, her environmental legacy remains one that divides critics from admirers. One sees it as a defense against ecological impoverishment, especially in her initiation of wildlife preservation and environmental conservation. The other views these as thin legitimization for an authoritarian style of funct...

  13. What is a Sorting Function?

    DEFF Research Database (Denmark)

    Henglein, Fritz

    2009-01-01

    What is a sorting function—not a sorting function for a given ordering relation, but a sorting function with nothing given? Formulating four basic properties of sorting algorithms as defining requirements, we arrive at intrinsic notions of sorting and stable sorting: A function is a sorting funct...... are derivable without compromising data abstraction. Finally we point out that stable sorting functions as default representations of ordering relations have the advantage of permitting linear-time sorting algorithms; inequality tests forfeit this possibility....

  14. Demographic differences in sport performers’ experiences of organizational stressors

    OpenAIRE

    Arnold, Rachel; Fletcher, David; Daniels, Kevin

    2016-01-01

    Organizational stressors are particularly prevalent across sport performers’ experiences and can influence their performance, health, and well-being. Research has been conducted to identify which organizational stressors are encountered by sport performers but little is known about how these experiences vary from athlete to athlete. The purpose of this study was to examine if the frequency, intensity, and duration of the organizational stressors that sport performers encounter vary as a funct...

  15. IT Solution for Security Management in the Cadastral Field

    OpenAIRE

    Emanuil REDNIC

    2011-01-01

    There are presented the particularities of cadastral system which should be reflected in the software development. It is shown as well the design of the cadastral software application. The online solution for the security management in the cadastral field, it is projected in this way to accomplish all the requirements. Another step is to identify the risks and vulnerability for the future processes, which gather all the functionality of the security system. It will be determined all the funct...

  16. Neuropsychology of prefrontal cortex

    OpenAIRE

    2008-01-01

    The history of clinical frontal lobe study is long and rich which provides valuable insights into neuropsychologic determinants of functions of prefrontal cortex (PFC). PFC is often classified as multimodal association cortex as extremely processed information from various sensory modalities is integrated here in a precise fashion to form the physiologic constructs of memory, perception, and diverse cognitive processes. Human neuropsychologic studies also support the notion of different funct...

  17. Protein target discovery of drug and its reactive intermediate metabolite by using proteomic strategy

    OpenAIRE

    Lianghai Hu; John Paul Fawcett; Jingkai Gu

    2012-01-01

    Identifying protein targets of bioactive compounds is an effective approach to discover unknown protein functions, identify molecular mechanisms of drug action, and obtain information for optimization of lead compounds. At the same time, metabolic activation of a drug can lead to cytotoxicities. Therefore, it is very important to systemically characterize the drug and its reactive intermediate. Mass spectrometry-based proteomic approach has emerged as the most efficient to study protein funct...

  18. Cross-functional interaction during the early phases of user-centered software new product development: reconsidering the common area of interest

    OpenAIRE

    Molin-Juustila, T. (Tonja)

    2006-01-01

    Abstract Applying the principles of user-centered development (UCD) in software development practice is not straightforward. In technology-push type software product development it is not clear how to match the new product innovation to the future needs of potential future users. Intensive collaboration between different organizational functions becomes essential. UCD provides valuable tools and practices as learning mechanisms both for users and for the company. The purpose of cross-funct...

  19. Acetylcholine receptors from human muscle as pharmacological targets for ALS therapy

    OpenAIRE

    Palma, Eleonora; Reyes-Ruiz, Jorge Mauricio; Lopergolo, Diego; Roseti, Cristina; Bertollini, Cristina; Ruffolo, Gabriele; Cifelli, Pierangelo; Onesti, Emanuela; Limatola, Cristina; Miledi, Ricardo; Inghilleri, Maurizio

    2016-01-01

    Amyotrophic lateral sclerosis (ALS) is a fatal disease leading to motor neuron degeneration and progressive paralysis. Other studies have revealed defects in skeletal muscle even in the absence of motor neuron anomalies, focusing on acetylcholine receptors (AChRs) and supporting the so-called “dying-back” hypothesis. Our results indicate that the endocannabinoid palmitoylethanolamide (PEA) reduces the rundown of AChRs currents in ALS muscle and can clinically improve patients’ pulmonary funct...

  20. Barrier mechanisms in the Drosophila blood-brain barrier

    OpenAIRE

    Samantha Jane Hindle; Roland Jerome Bainton

    2014-01-01

    The invertebrate blood-brain barrier field is growing at a rapid pace and, in recent years, studies have shown a physiologic and molecular complexity that has begun to rival its vertebrate counterpart. Novel mechanisms of paracellular barrier maintenance through GPCR signaling were the first demonstrations of the complex adaptive mechanisms of barrier physiology. Building upon this work, the integrity of the invertebrate blood-brain barrier has recently been shown to require coordinated funct...

  1. Radial Basis Function Network Compensators for Uncertainties of Robotic Manipulators

    OpenAIRE

    Ziauddin, S.M.; Zalzala, A.M.S.

    1994-01-01

    This report proposes a decentralised compensation scheme for uncertainties and modelling errors of robotic manipulators. The scheme employs a central decoupler and independent joint neural network controllers. Recursive Newton Euler formulas are used to decouple robot dynamics to obtain a set of equations in terms of each joint's input and output. To identify and suppress the effects of uncertainties associated with the model, each joint is controlled separately by Gaussian radial basis funct...

  2. Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats

    OpenAIRE

    Roberts, Jenny R; Antonini, James M.; Porter, Dale W.; Chapman, Rebecca S.; Scabilloni, James F.; Young, Shih-Houng; Schwegler-Berry, Diane; CASTRANOVA, VINCENT; Mercer, Robert R.

    2013-01-01

    Background The potential use of quantum dots (QD) in biomedical applications, as well as in other systems that take advantage of their unique physiochemical properties, has led to concern regarding their toxicity, potential systemic distribution, and biopersistence. In addition, little is known about workplace exposure to QD in research, manufacturing, or medical settings. The goal of the present study was to assess pulmonary toxicity, clearance, and biodistribution of QD with different funct...

  3. The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm

    OpenAIRE

    Jiaze Li; Smriti Murali Krishna; Jonathan Golledge

    2016-01-01

    Abdominal aortic aneurysm (AAA) is a vascular condition that causes permanent dilation of the abdominal aorta, which can lead to death due to aortic rupture. The only treatment for AAA is surgical repair, and there is no current drug treatment for AAA. Aortic inflammation, vascular smooth muscle cell apoptosis, angiogenesis, oxidative stress and vascular remodeling are implicated in AAA pathogenesis. Kallistatin is a serine proteinase inhibitor, which has been shown to have a variety of funct...

  4. High-Speed Imaging Reveals Opposing Effects of Chronic Stress and Antidepressants on Neuronal Activity Propagation through the Hippocampal Trisynaptic Circuit

    OpenAIRE

    Jens eStepan; Florian eHladky; Andrés eUribe; Florian eHolsboer; Schmidt, Mathias V.; Matthias eEder

    2015-01-01

    Antidepressants (ADs) are used as first-line treatment for most stress-related psychiatric disorders. The alterations in brain circuit dynamics that can arise from stress exposure and underlie therapeutic actions of ADs remain, however, poorly understood. Here, enabled by a recently developed voltage-sensitive dye imaging assay in mouse brain slices, we examined the impact of chronic stress and concentration-dependent effects of eight clinically used ADs (belonging to different chemical/funct...

  5. Automated Techniques for Hash Function and Block Cipher Cryptanalysis (Automatische technieken voor hashfunctie- en blokcijfercryptanalyse)

    OpenAIRE

    2012-01-01

    Cryptography is the study of mathematical techniques that ensure the confidentiality and integrity of information. This relatively new field started out as classified military technology, but has now become commonplace in our daily lives. Cryptography is not only used in banking cards, secure websites and electronic signatures, but also in public transport cards, car keys and garage door openers.Two building blocks in the domain of cryptography are block ciphers and (cryptographic) hash funct...

  6. Quantum and Classic Brackets

    OpenAIRE

    Kisil, Vladimir V.

    2000-01-01

    We describe an $p$-mechanical (see funct-an/9405002 and quant-ph/9610016) brackets which generate quantum (commutator) and classic (Poisson) brackets in corresponding representations of the Heisenberg group. We \\emph{do not} use any kind of semiclassic approximation or limiting procedures for $\\hbar \\to 0$. Harmonic oscillator considered within the approach. Keywords: Classic and quantum mechanics, Hamilton and Heisenberg equations, Poisson brackets, commutator, Heisenberg group.

  7. Cartan MASAs in von Neumann Algebras are Norming and a New Proof of Mercer's Theorem

    CERN Document Server

    Cameron, Jan; Zarikian, Vrej

    2012-01-01

    In this note we observe that a result of Sinclair and Smith together with the Feldman-Moore description of a von Neumann algebra with a Cartan MASA shows that Cartan MASAs are norming. We also use the outline in Remark 2.17 of [D. R. Pitts, Proc. Amer. Math. Soc., 2008] to give a new proof of Mercer's Theorem [R. Mercer, J. Funct. Anal., 1991, Corollary 4.3].

  8. Nicotinic receptor abnormalities in Alzheimer's and Parkinson's diseases.

    OpenAIRE

    1987-01-01

    The status of cholinergic receptors in dementia is related to the question of potential cholinergic therapy. Whilst muscarinic receptor binding is generally reported to be normal or near normal, findings are reported which indicate substantial reductions of hippocampal nicotinic (high affinity nicotine) binding (occurring in conjunction with decreased choline acetyltransferase) in both Alzheimer's and Parkinson's but not Huntington's disease. A further indication that nicotinic receptor funct...

  9. High Fidelity Down-Conversion Source for Secure Communications using On-Demand Single Photons Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this NASA SBIR Phase II effort, AdvR will design and build an efficient, fully integrated, waveguide based, source of spectrally uncorrelated photon pairs that...

  10. Neutrophil surface adhesion molecule and toll like receptor dynamics in crossbred cows suffering from Staphylococcus aureus subclinical and clinical mastitis

    Directory of Open Access Journals (Sweden)

    Dilip Kumar Swain

    2016-06-01

    Conclusion: Host elicits stage specific expression of surface adhesion molecules and TLR2 and TLR4 as dynamic host innate immune response against Staphylococcal mastitis. [J Adv Vet Anim Res 2016; 3(2.000: 99-105

  11. Multi-channel tunable source for atomic sensors Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR will establish the feasibility of developing compact, robust, integrated components suitable for atomic interferometry. AdvR's design is enabled by...

  12. Antibody-forming cells and serum hemolysin responses of pastel and sapphire mink inoculated with Aleutian disease virus.

    Science.gov (United States)

    Lodmell, D L; Bergman, R K; Hadlow, W J

    1973-11-01

    The effect of Aleutian disease virus (ADV) on serum hemolysin titers and antibody-forming cells in lymph nodes and spleens of sapphire and pastel mink inoculated with goat erythrocytes (G-RBC) was investigated. ADV injected 1 day after primary antigenic stimulation with G-RBC did not depress the immune responses of either color phase for a period of 26 days. However, when G-RBC were injected 47 days after ADV, both the number of antibody-forming cells and hemolysin titers were more markedly depressed in sapphire than in pastel mink. The results are discussed in relation to the greater susceptibility of sapphire mink and the variable susceptibility of pastel mink to the Pullman isolate of ADV.

  13. Demonstration of Aleutian disease virus-specific lymphocyte response in mink with progressive Aleutian disease: comparison of sapphire and pastel mink infected with different virus strains.

    Science.gov (United States)

    Race, R E; Bloom, M E; Coe, J E

    1983-09-01

    Lymphocyte blastogenesis was used to study the antiviral lymphocyte response of sapphire (Aleutian) and pastel (nonAleutian) mink inoculated with Pullman or Utah 1 Aleutian disease virus (ADV). Both mink genotypes developed a virus-specific response when inoculated with Utah 1 ADV. In contrast, after inoculation of Pullman ADV, sapphire mink had a positive virus-specific response, whereas pastel mink did not. Response occurred late after infection (8 wk) and correlated with the development of progressive Aleutian disease (AD). The response to keyhole limpet hemocyanin (KLH) and concanavalin A (Con A) was also determined. Most mink of either genotype, inoculated with either virus strain, maintained an anti-KLH response during disease. Most mink also responded to Con A, although some exhibited suppressed Con A response late in the disease course. These results indicated that mink develop an anti-ADV lymphocyte response during progressive AD and are not immunosuppressed with regard to other antigens or mitogens.

  14. Coincidence of congenital left-sided diaphragmatic hernia and ductus venosus agenesis: Relation between altered hemodynamic flow and lung-to-head-ratio?

    Directory of Open Access Journals (Sweden)

    T. Klein

    2015-06-01

    Full Text Available Left-sided diaphragmatic hernia (CDH as well as ductus venosus agenesis (ADV are rare complex congenital malformations. We present a case of coincidence of these malformations and an abnormally high lung-head-ratio (LHR. The left-sided liver-up CDH and the ADV were diagnosed in prenatal ultrasound examination. In CDH cases lung volume is decreased due to the herniation of abdominal organs into the thorax. With 1.4 the LHR of our patient exceeded the normal ratio in liver-up CDH cases considerably. One explanation for this unusually high LHR might be an altered blood flow due to the coinciding ADV. In ADV cases less blood bypasses the lung through the foramen ovale. Consecutively pulmonary circulation is improved which may constitute as an advantage in CDH cases. Diagnosis, prognostic factors, physiology, and therapy strategy are discussed.

  15. 75 FR 69507 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-11-12

    ... Endnote 3 of the Fee Schedule, ``Liquidity Adding ADV'') is less than 25 million shares (``Tier 1''); a... (``TCADV''). As set forth in Explanatory Endnote 13, TCADV means average daily volume reported by...

  16. Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.

    Science.gov (United States)

    Hartline, Caroll B; Gustin, Kortney M; Wan, William B; Ciesla, Stephanie L; Beadle, James R; Hostetler, Karl Y; Kern, Earl R

    2005-02-01

    The acyclic nucleoside phosphonate cidofovir (CDV) and its closely related analogue (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-adenine ([S]-HPMPA) have been reported to have activity against many adenovirus (AdV) serotypes. A new series of orally active ether lipid-ester prodrugs of CDV and of (S)-HPMPA that have slight differences in the structure of their lipid esters were evaluated, in tissue-culture cells, for activity against 5 AdV serotypes. The results indicated that, against several AdV serotypes, the most active compounds were 15-2500-fold more active than the unmodified parent compounds and should be evaluated further for their potential to treat AdV infections in humans.

  17. Ridge Waveguide Structures in Magnesium-Doped Lithium Niobate Project

    Data.gov (United States)

    National Aeronautics and Space Administration — AdvR, Inc. proposes the development of an efficient process for fabricating ridge waveguides in magnesium-doped lithium niobate (MgO:LN). The effort will include,...

  18. 78 FR 51242 - Self-Regulatory Organizations; Topaz Exchange, LLC; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-08-20

    ... little as $0.10 per contract based on that members' ADV at BOX-- keeping in mind that the `Credit for... Customer is by definition not a broker or dealer in securities, and does not place more than 390 orders...

  19. Disease: H00594 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available pathogenesis of distal muscular dystrophies. Adv Exp Med Biol 652:23-38 (2009) PMID:17029922 (gene, description) Udd B Molecular biol...ogy of distal muscular dystrophies--sarcomeric proteins on top. Biochim Biophys Act

  20. Guidelines for submitting adverse event reports for publication

    NARCIS (Netherlands)

    Kelly, William; Arellano, Felix; Barnes, Joanne; Bergman, Ulf; Edwards, Ralph; Fernandez, Alina; Freedman, Stephen; Goldsmith, David; Huang, Kui; Jones, Judith; McLeay, Rachel; Moore, Nicholas; Stather, Rosie; Trenque, Thierry; Troutman, William; van Puijenbroek, Eugène; Williams, Frank; Wise, Robert

    2009-01-01

    Publication of case reports describing suspected adverse effects of drugs and medical products that include herbal and complementary medicines, vaccines and other biologicals and devices is important for postmarketing surveillance. Publication lends credence to important signals raised in these adve

  1. Highly Efficient, Compact, Wavelength Converters for Pulsed and CW Laser Sources Used in Lidar-Based Remote Sensing and Ranging Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — AdvR, Inc. proposes the development of a highly efficient, fiber pigtailed, waveguide-based UV frequency converter module. This UV module will be an important...

  2. Prevalence of intestinal parasitism of swine in a North Central State of Nigeria

    Directory of Open Access Journals (Sweden)

    Julius Olaniyi Aiyedun

    2016-09-01

    Conclusion: The prevalence of parasites in pigs obtained in this work is a consequence of improper husbandry measures and irregular veterinary medical intervention. [J Adv Vet Anim Res 2016; 3(3.000: 278-281

  3. Measuring Turbulence from Moored Acoustic Doppler Velocimeters. A Manual to Quantifying Inflow at Tidal Energy Sites

    Energy Technology Data Exchange (ETDEWEB)

    Kilcher, Levi [National Renewable Energy Lab. (NREL), Golden, CO (United States); Thomson, Jim [Univ. of Washington, Seattle, WA (United States); Talbert, Joe [Univ. of Washington, Seattle, WA (United States); DeKlerk, Alex [Univ. of Washington, Seattle, WA (United States)

    2016-03-01

    This work details a methodology for measuring hub height inflow turbulence using moored acoustic Doppler velocimiters (ADVs). This approach is motivated by the shortcomings of alternatives. For example, remote velocity measurements (i.e., from acoustic Doppler profilers) lack sufficient precision for device simulation, and rigid tower-mounted measurements are very expensive and technically challenging in the tidal environment. Moorings offer a low-cost, site-adaptable and robust deployment platform, and ADVs provide the necessary precision to accurately quantify turbulence.

  4. Technical Needs for Prototypic Prognostic Technique Demonstration for Advanced Small Modular Reactor Passive Components

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Ryan M.; Coble, Jamie B.; Hirt, Evelyn H.; Ramuhalli, Pradeep; Mitchell, Mark R.; Wootan, David W.; Berglin, Eric J.; Bond, Leonard J.; Henager, Charles H.

    2013-05-17

    This report identifies a number of requirements for prognostics health management of passive systems in AdvSMRs, documents technical gaps in establishing a prototypical prognostic methodology for this purpose, and describes a preliminary research plan for addressing these technical gaps. AdvSMRs span multiple concepts; therefore a technology- and design-neutral approach is taken, with the focus being on characteristics that are likely to be common to all or several AdvSMR concepts. An evaluation of available literature is used to identify proposed concepts for AdvSMRs along with likely operational characteristics. Available operating experience of advanced reactors is used in identifying passive components that may be subject to degradation, materials likely to be used for these components, and potential modes of degradation of these components. This information helps in assessing measurement needs for PHM systems, as well as defining functional requirements of PHM systems. An assessment of current state-of-the-art approaches to measurements, sensors and instrumentation, diagnostics and prognostics is also documented. This state-of-the-art evaluation, combined with the requirements, may be used to identify technical gaps and research needs in the development, evaluation, and deployment of PHM systems for AdvSMRs. A preliminary research plan to address high-priority research needs for the deployment of PHM systems to AdvSMRs is described, with the objective being the demonstration of prototypic prognostics technology for passive components in AdvSMRs. Greater efficiency in achieving this objective can be gained through judicious selection of materials and degradation modes that are relevant to proposed AdvSMR concepts, and for which significant knowledge already exists. These selections were made based on multiple constraints including the analysis performed in this document, ready access to laboratory-scale facilities for materials testing and measurement, and

  5. 新目标英语七年级(下)Unit 9知识要点归纳

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    一、重点词汇straight adj.直的tall adj.高的height n.高度;身高thin adj.瘦的heavy adj.重的build n.身材tonight adv.&n.(在)今晚little adj.小的cinema n.电影院glasses(pl.)n.眼镜later adv.以后handsome adj.英俊的actor n.

  6. Promoting the demoted

    DEFF Research Database (Denmark)

    Jensen, Torben Juel; Christensen, Tanya Karoli

    2013-01-01

    In this article, we investigate a hypothesis regarding the distinction between the word orders ‘finite verb, adverb’ (V>Adv, in Scandinavian linguistics often considered an instance of V2, also in subject initial clauses) and ‘adverb, finite verb’ (Adv>V, sometimes referred to as V3) in Mainland ...... seemingly in conflict with predictions of the semantico-pragmatic hypothesis are discussed with respect to possible norm conflicts and shifts in communicative strategy during speech production....

  7. “SÓ”, “EXCLUSIVAMENTE” E SUAS POSIÇÕES NA SENTENÇA

    Directory of Open Access Journals (Sweden)

    Aquiles TESCARI NETO

    2015-12-01

    Full Text Available Neste artigo, são examinadas algumas propriedades de advérbios altos e baixos para mostrar que o focalizador só pertence ao primeiro grupo. Conclui-se que o comportamento do advérbio de exclusão só no Português do Brasil é mais bem explicado do ponto de vista da Sintaxe, isto é, em termos da sua posição na hierarquia universal. A pista para chegar a tal conclusão vem da distribuição do focalizador exclusivamente, que também é um advérbio de exclusão, mas se comporta de forma diferente em relação a sóno que diz respeito a algumas propriedades sintáticas que põem de um lado os advérbios altos e de outro os baixos. Além disso, este texto revela que a previsão de Bever e Clark (2008 – de que a Semântica seria responsável pelas assimetrias entre os advérbios quantificacionais e o exclusivo só – não é correta, na medida em que o focalizador de exclusão exclusivamente, no Português do Brasil, compartilha propriedades sintáticas com advérbios quantificacionais.

  8. Development and validation of a novel hydrolysis probe real-time polymerase chain reaction for agamid adenovirus 1 in the central bearded dragon (Pogona vitticeps).

    Science.gov (United States)

    Fredholm, Daniel V; Coleman, James K; Childress, April L; Wellehan, James F X

    2015-03-01

    Agamid adenovirus 1 (AgAdv-1) is a significant cause of disease in bearded dragons (Pogona sp.). Clinical manifestations of AgAdv-1 infection are variable and often nonspecific; the manifestations range from lethargy, weight loss, and inappetence, to severe enteritis, hepatitis, and sudden death. Currently, diagnosis of AgAdv-1 infection is achieved through a single published method: standard nested polymerase chain reaction (nPCR) and sequencing. Standard nPCR with sequencing provides reliable sensitivity, specificity, and validation of PCR products. However, this process is comparatively expensive, laborious, and slow. Probe hybridization, as used in a TaqMan assay, represents the best option for validating PCR products aside from the time-consuming process of sequencing. This study developed a real-time PCR (qPCR) assay using a TaqMan probe-based assay, targeting a highly conserved region of the AgAdv-1 genome. Standard curves were generated, detection results were compared with the gold standard conventional PCR and sequencing assay, and limits of detection were determined. Additionally, the qPCR assay was run on samples known to be positive for AgAdv-1 and samples known to be positive for other adenoviruses. Based on the results of these evaluations, this assay allows for a less expensive, rapid, quantitative detection of AgAdv-1 in bearded dragons.

  9. Chemistry and Mineralogy of Antarctica Dry Valley Soils: Implications for Mars

    Science.gov (United States)

    Quinn, J. E.; Golden, D. C.; Graff, T. G.; Ming, D. W.; Morris, R. V.; Douglas, S.; Kounaves, S. P.; McKay, C. P.; Tamppari, L, K.; Smith, P. H.; Zent, A. P.; Archer, P. D., Jr.

    2011-01-01

    The Antarctic Dry Valleys (ADV) comprise the largest ice-free region of Antarctica. Precipitation almost always occurs as snow, relative humidity is frequently low, and mean annual temperatures are about -20 C. The ADV soils have previously been categorized into three soil moisture regimes: subxerous, xerous and ultraxerous, based on elevation and climate influences. The subxerous regime is predominately a coastal zone soil, and has the highest average temperature and precipitation, while the ultraxerous regime occurs at high elevation (>1000 m) and have very low temperature and precipitation. The amounts and types of salts present in the soils vary between regions. The nature, origin and significance of salts in the ADV have been previously investigated. Substantial work has focused on soil formation in the ADVs, however, little work has focused on the mineralogy of secondary alteration phases. The dominant weathering process in the ADV region is physical weathering, however, chemical weathering has been well documented. The objective of this study was to characterize the chemistry and mineralogy, including the alteration mineralogy, of soils from two sites, a subxerous soil in Taylor Valley, and an ultraxerous soil in University Valley. The style of aqueous alteration in the ADVs may have implications for pedogenic processes on Mars.

  10. Construction and characterization of adenoviral vectors for the delivery of TALENs into human cells.

    Science.gov (United States)

    Holkers, Maarten; Cathomen, Toni; Gonçalves, Manuel A F V

    2014-09-01

    Transcription activator-like effector nucleases (TALENs) are designed to cut the genomic DNA at specific chromosomal positions. The resulting DNA double strand break activates cellular repair pathways that can be harnessed for targeted genome modifications. TALENs thus constitute a powerful tool to interrogate the function of DNA sequences within complex genomes. Moreover, their high DNA cleavage activity combined with a low cytotoxicity make them excellent candidates for applications in human gene therapy. Full exploitation of these large and repeat-bearing nucleases in human cell types will benefit largely from using the adenoviral vector (AdV) technology. The genetic stability and the episomal nature of AdV genomes in conjunction with the availability of a large number of AdV serotypes able to transduce various human cell types make it possible to achieve high-level and transient expression of TALENs in numerous target cells, regardless of their mitotic state. Here, we describe a set of protocols detailing the rescue, propagation and purification of TALEN-encoding AdVs. Moreover, we describe procedures for the characterization and quantification of recombinant viral DNA present in the resulting AdV preparations. The protocols are preceded by information about their underlying principles and applied in the context of second-generation capsid-modified AdVs expressing TALENs targeted to the AAVS1 "safe harbor" locus on human chromosome 19.

  11. Prevalence of neutralising antibodies against adenoviruses in lizards and snakes.

    Science.gov (United States)

    Ball, Inna; Ofner, Sabine; Funk, Richard S; Griffin, Chris; Riedel, Ulf; Möhring, Jens; Marschang, Rachel E

    2014-10-01

    Adenoviruses (AdVs) are relatively common in lizards and snakes, and several genetically distinct AdVs have been isolated in cell culture. The aims of this study were to examine serological relationships among lizard and snake AdVs and to determine the frequency of AdV infections in these species. Isolates from a boa constrictor (Boa constrictor), a corn snake (Pantherophis gutattus) and a central bearded dragon (Pogona vitticeps), and two isolates from helodermatid lizards (Heloderma horridum and H. suspectum) were used in neutralisation tests for the detection of antibodies in plasma from 263 lizards from seven families (including 12 species) and from 141 snakes from four families (including 28 species) from the USA and Europe. Most lizard and snake samples had antibodies against a range of AdV isolates, indicating that AdV infection is common among these squamates. Neutralisation tests with polyclonal antibodies raised in rabbits demonstrated serological cross-reactivity between both helodermatid lizard isolates. However, squamate plasma showed different reactions to each of these lizard isolates in neutralisation tests.

  12. The role of endosomal escape and mitogen-activated protein kinases in adenoviral activation of the innate immune response.

    Directory of Open Access Journals (Sweden)

    Jeffrey S Smith

    Full Text Available Adenoviral vectors (AdV activate multiple signaling pathways associated with innate immune responses, including mitogen-activated protein kinases (MAPKs. In this study, we investigated how systemically-injected AdVs activate two MAPK pathways (p38 and ERK and the contribution of these kinases to AdV-induced cytokine and chemokine responses in mice. Mice were injected intravenously either with a helper-dependent Ad2 vector that does not express viral genes or transgenes, or with the Ad2 mutant ts1, which is defective in endosomal escape. We found that AdV induced rapid phosphorylation of p38 and ERK as well as a significant cytokine response, but ts1 failed to activate p38 or ERK and induced only a limited cytokine response. These results demonstrate that endosomal escape of virions is a critical step in the induction of these innate pathways and responses. We then examined the roles of p38 and ERK pathways in the innate cytokine response by administering specific kinase inhibitors to mice prior to AdV. The cytokine and chemokine response to AdV was only modestly suppressed by a p38 inhibitor, while an ERK inhibitor has mixed effects, lowering some cytokines and elevating others. Thus, even though p38 and ERK are rapidly activated after i.v. injection of AdV, cytokine and chemokine responses are mostly independent of these kinases.

  13. The relationship between adenovirus-36 seropositivity, obesity and metabolic profile in Turkish children and adults.

    Science.gov (United States)

    Karamese, M; Altoparlak, U; Turgut, A; Aydogdu, S; Karamese, S Aksak

    2015-12-01

    Obesity potentially arising from viral infection is known as 'infectobesity'. The latest reports suggest that adenovirus-36 (Adv36) is related to obesity in adults and children. Our aim was not only to determine the Adv36 seropositivity in both obese and non-obese children and adults, but also to investigate correlations between antibody positivity and serum lipid profiles. Both Adv36 positivity and tumour-necrosis-factor-alpha, leptin and interleukin-6 levels were detected in blood samples collected from 146 children and 130 adults by ELISA. Fasting plasma triglycerides, total cholesterol and low-density lipoprotein levels were also measured. Adv36 positivity was determined to be 27·1% and 6% in obese and non-obese children and 17·5% and 4% in obese and non-obese adults, respectively. There was no difference with regard to total cholesterol, low-density lipoprotein, triglyceride, tumour-necrosis-factor-alpha and interleukin-6 levels (P > 0·05). However, there was a significant difference between groups in terms of leptin levels (P obese children and adults. Our results showed that Adv36 may be an obesity agent for both adults and children, parallel with current literature data. However, the available data on a possible relationship between Adv36 infection and obesity both in children and adults do not completely solve the problem.

  14. Correlation between Optical Properties and Chemical Composition of Sputter-Deposited Germanium Oxide (GEOX) Films (Postprint)

    Science.gov (United States)

    2014-03-18

    Zhang, W. Que, J. Chen, X. Zhang, J. Hu, W. Liu, Opt. Mater. 35 (2013) 2556– 2560. [11] B.G. Segda, M. Jacquet, C. Caapera, G . Baud , J. Pierre Besse...Samanoudy, J. Mater. Sci. Lett. 6 (1987) 1447–1449. [20] C. Caperaa, G . Baud , J.P. Besse, P. Bondot, P. Fessler, M. Jacquet, Mater. Res. Bull. 24 (1989...POSTPRINT) Neil R. Murphy, J. G . Jones, and R. Jakubiak AFRL/RXAP MARCH 2014 Interim Report Approved for public release

  15. Humane mlečne banke

    OpenAIRE

    Ćosić, Ana

    2013-01-01

    Humane mlečne banke zbirajo, nadzorujejo, obdelujejo, shranjujejo in razdeljujejo darovano mleko. Namenjene so nedonošenčkom in bolnim novorojenčkom, katerih matere nimajo mleka. Namen raziskave je bil ugotoviti osveščenost mater o pomembnosti humanih mlečnih bank. Uporabili smo deskriptivno metodo raziskovanja. Ugotovili smo, da so matere osveščene o pomembnosti humanih mlečnih bank in zato tudi posledično čimprejšnja ustanovitev humane mlečne banke v Sloveniji.

  16. CGRP infusion in unanesthetized rats increases expression of c-Fos in the nucleus tractus solitarius and caudal ventrolateral medulla, but not in the trigeminal nucleus caudalis

    DEFF Research Database (Denmark)

    Bhatt, Deepak K; Ramachandran, Roshni; Christensen, Sarah Louise Tangsgaard

    2015-01-01

    sites in the brain stem for processing cardiovascular signals. We also investigated Zif268 protein expression (another immediate early gene) in TNC. The protein expression of p-ERK, p-CREB and c-Fos was analyzed in dura mater, trigeminal ganglion (TG) and TNC samples using Western blot. RESULTS: CGRP...... in the TNC was also not changed after CGRP infusion. p-ERK was increased in the dura mater 30 minutes after CGRP infusion. CONCLUSION: CGRP infusion increased the early expression of p-ERK in the dura mater but did not increase c-Fos and Zif268 expression in the TNC. The rats may, thus, differ from migraine...

  17. The Effect of Hardness on Eddy Current Residual Stress Profiling in Shot-Peened Nickel Alloys

    Science.gov (United States)

    2010-06-22

    Inconel 718 alloy. Mater. Charact. 61, 49 (2010) 34. Lifshitz, I.M., Slyozov, V.V.: The kinetics of precipitation from su- persaturated solid... 718 . Mater. Sci. Eng. A 486, 117 (2008) 37. Han, Y.F., Deb, P., Chaturvedi, M.C.: Coarsening behaviour of γ ′′- and γ ′-particles in Inconel alloy 718 ...Met. Sci. 16, 555 (1982) 38. Sundaraman, M., Mukhopadhyay, P., Banerjee, S.: Some aspects of the precipitation of metastable intermetallic phases in Inconel 718 . Metall. Mater. Trans. A 23, 2015 (1992)

  18. Superelasticity in bcc Nanowires by a Reversible Twinning Mechanism

    Science.gov (United States)

    2010-11-29

    example, a stacking fault forms at first from the perfect nanowires. The embryo subsequently forms in a layer-by-layer manner with respect to the...Kondo and K. Takayanagi, Phys. Rev. Lett. 79, 3455 1997. 30 J. W. Christian and S. Mahajan, Prog. Mater. Sci. 39, 1 1995. 31 B. Q. Li, M. L. Sui, B...Froseth, Nature Mater. 3, 399 2004. 36 S. Kibey, J. B. Liu, D. D. Johnson, and H. Sehitoglu, Acta Mater. 55, 6843 2007. 37 J. W. Christian , Metall

  19. Influence of mycorhization and soil organic matters on lead and antimony transfers to vegetables cultivated in urban gardens: environmental and sanitary consequences

    Science.gov (United States)

    Pierart, Antoine; Braud, Armelle; Lebeau, Thierry; Séjalon-Delmas, Nathalie; Dumat, Camille

    2014-05-01

    . References: Feng, R., Wei, C., Tu, S., Ding, Y., Wang, R., Guo, J., 2013. The uptake and detoxification of antimony by plants: a review. Environ. Exp. Bot. 96, 28-34. Foucault, Y., Lévêque, T., Xiong, T., Schreck, E., Austruy, A., Shahid, M., Dumat, C., 2013. Green manure plants for remediation of soils polluted by metals and metalloids: Ecotoxicity and human bioavailability assessment. Chemosphere 93, 1430-1435. Gu, H.H., Li, F.P., Yu, Q., Gao, Y.Q., Yuan, X.T., 2013. The Roles of Arbuscular Mycorrhizal Fungus Glomus mosseae and Festuca arundinacea in Phytostabilization of Lead/Zinc Tailings. Adv. Mater. Res. 699, 245-250. Lebeau, T., Braud, A., Jézéquel, K., 2008. Performance of bioaugmentation-assisted phytoextraction applied to metal contaminated soils: A review. Environ. Pollut. 153, 497-522. Sharma, A., Sharma, H., 2013. Role of Vesicular Arbuscular Mycorrhiza in the Mycoremediation of Heavy Toxic Metals From Soil. Int J LifeSc Bt Pharm Res 2, 2418-2431. Wu, F., Fu, Z., Liu, B., Mo, C., Chen, B., Corns, W., Liao, H., 2011. Health risk associated with dietary co-exposure to high levels of antimony and arsenic in the world's largest antimony mine area. Sci. Total Environ. 409, 3344-3351. Xiong, T., Austruy, A., Dappe, V., Leveque, T., Sobanska, S., Foucault, Y., Dumat, C., 2013. Phytotoxicity and bioaccessibility of metals for vegetables exposed to atmosphere fine particles in polluted urban areas". Urban Environmental Pollution, Asian Edition, 17-20, Beijing, China.

  20. Colored ultra-thin hybrid photovoltaics with high quantum efficiency for decorative PV applications (Presentation Recording)

    Science.gov (United States)

    Guo, L. Jay

    2015-10-01

    adopted by other material systems as well. Based on these understandings, we have also developed colored perovskite PV by integrating an optical cavity with the perovskite semiconductors [4]. The principle and experimental results will be presented. 1. J. Y. Lee, K. T. Lee, S.Y. Seo, L. J. Guo, "Decorative power generating panels creating angle insensitive transmissive colors," Sci. Rep. 4, 4192, 2014. 2. K. T. Lee, J.Y. Lee, S.-Y. Seo, and L. J. Guo, "Colored ultra-thin hybrid photovoltaics with high quantum efficiency," Light: Science and Applications, 3, e215, 2014. 3. K. T. Lee, S.-Y. Seo, J.Y. Lee, and L. J. Guo, "Ultrathin metal-semiconductor-metal resonator for angle invariant visible band transmission filters," Appl. Phys. Lett. 104, 231112, (2014); and "Strong resonance effect in a lossy medium-based optical cavity for angle robust spectrum filters," Adv. Mater, 26, 6324-6328, 2014. 4. K. T. Lee, M. Fukuda, L. J. Guo, "Colored, see-through perovskite solar cells employing an optical cavity," Submitted, 2015

  1. Imaging nanomaterials in vitro and in vivo by exploring their intrinsic nonlinear optical signals

    Science.gov (United States)

    Tong, Ling

    . First, receptor-medicated endocytosis is visualized with a polymeric nanoparticle-based CARS probe (J. Phys. Chem. B, 2007, 111, 9980-9985). Second, the cellular drug delivery mechanism by poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) is reexamined by CARS microscopy and new discoveries that PLGA NPs are not readily taken up by cells and delivered the payload to cells by extracellular drug release and/or direct drug transfer to contacting cells are found (Mol. Pharmaceutics, 2009, 6, 190-201). Third, the sensitivity of SRS microscopy is improved to monitor liposomal drug delivery in live cells. The last part of my thesis depicts the applications of GNRs in diagnosis and phtotothermal therapy of tumor cells and activated macrophages. Photothermal effect of GNRs is monitored by TPL, confocal microscopy and biological assays. The formation of membrane blebs is observed. The subcellular mechanism is investigated to be a downstream effect of compromised membrane integrity, which permits influx of calcium and subsequent disruption of the actin network (Adv. Mater. 2007, 109, 3136-3141, cover story). In addition, cell death through necrosis or apoptosis is induced by controlling laser irradiation. The molecular mechanisms are determined as the loss of plasma membrane integrity for necrosis and intracellular perturbation with damage of mitochondria for apoptosis (Nanomedicine, 2009, 4, 265-276).

  2. EDITORIAL: Bioengineering nanotechnology: towards the clinic Bioengineering nanotechnology: towards the clinic

    Science.gov (United States)

    Zhao, Weian; Karp, Jeffrey M.; Ferrari, Mauro; Serda, Rita

    2011-12-01

    special issue highlights some of the most recent advances in the exciting field of bioengineering nanotechnology. The themes covered in this issue include nanoparticle systems for tracking transplanted stem cells using a variety of imaging modalities, synthesis of smart nanomaterials for drug delivery and targeting specific intracellular organalles, elucidating how physical cues provided by nano- or micro-fabricated scaffolds impact cell phenotype, novel nanocomposite materials for biosensing, biomimetic assembly of nanostructures for studying molecular interactions, and high content analysis for assessing nanotoxicity. We believe next-generation nanomaterials that are currently under development will transform our understanding of biological mechanisms, and revolutionize clinical practice through ushering in new diagnostics and therapeutic paradigms. As nanotechnology becomes increasingly accessible to research laboratories, significant advances leading to paradigm shifts in basic biology and medicine will require connecting the right technology to the right problem and ensuring that the most pertinent criteria are correctly identified and addressed. References [1] Peer D et al Nat. Nanotechnol. 2 751-60 [2] Wang A Z, Langer R S and Farokhzad O C 2011 Annu. Rev. Med. doi: 10.1146/annurev-med-040210-162544 [3] Farokhzad O C and Langer R 2006 Adv. Drug Deliv. Rev. 58 1456-9 [4] Zhao W and Karp J M 2009 Nat. Mater. 8 453-4 [5] Ferreira L, Karp J M, Nobre L and Langer R 2008 Cell Stem Cell 3 136-46 [6] Zhao W and Karp J M 2009 ChemBioChem 10 2308-10 [7] Zhao W et al 2011 Nat. Nanotechnol. 6 524-31 [8] Stephan M T, Moon J J, Um S H, Bershteyn A and Irvine D J 2010 Nat. Med. 16 1035-41 [9] Sarkar D, Ankrum J A, Teo G S, Carman C V and Karp J M 2011 Biomaterials 32 3053-61

  3. Evidence for variable crystallinity in bivalve shells

    Science.gov (United States)

    Jacob, D. E.; Wehrmeister, U.

    2012-04-01

    ]. Remnants of ACC can be traced by Raman spectroscopy and allow insight into the processes of biomineralization in bivalves. The crystallinity of solid materials can be quantified Raman spectroscopy by comparison of the FWHM of the ν1- Raman peak. We developed a Raman crystallinity index in order to get a measure of the degree of crystallinity [4]. Results presented for shells from several different marine and freshwater bivalve species and compare these with synthetically ACC and stable ACC from Porcellio scaber. The crystalline fraction in the different ACC-areas in shells and pearls supports the hypothesis that ACC acts as a transient precursor to crystalline CaCO3, in which the polymorph is already moulded into nanoclusters. The distribution and the state of crystallization of the calcium carbonate polymorphs in most of the ACC areas are not homogenous and the term ACC includes structurally different material. [1] Jacob et al., 2008, Geochim. Cosmochim. Acta 72, 229, [2] Jacob et al., 2011; J. Struct. Biol. 173 (2), 241, [3] Addadi et al., Adv. Mater. 2003; (15), 959, [4] Wehrmeister et al., 2011. J. Raman Spectrosc. 42, (5), 926.

  4. Current and future disease progression of the chronic HCV population in the United States.

    Science.gov (United States)

    Zalesak, Martin; Francis, Kevin; Gedeon, Alex; Gillis, John; Hvidsten, Kyle; Kidder, Phyllis; Li, Hong; Martyn, Derek; Orne, Leslie; Smith, Amanda; Kwong, Ann

    2013-01-01

    Chronic hepatitis C virus (HCV) infection can lead to advanced liver disease (AdvLD), including cirrhosis, decompensated cirrhosis, and liver cancer. The aim of this study was to determine recent historical rates of HCV patient progression to AdvLD and to project AdvLD prevalence through 2015. We first determined total 2008 US chronic HCV prevalence from the National Health and Nutrition Evaluation Surveys. Next, we examined disease progression and associated non-pharmacological costs of diagnosed chronic HCV-infected patients between 2007-2009 in the IMS LifeLink and CMS Medicare claims databases. A projection model was developed to estimate AdvLD population growth through 2015 in patients diagnosed and undiagnosed as of 2008, using the 2007-2009 progression rates to generate a "worst case" projection of the HCV-related AdvLD population (i.e., scenario where HCV treatment is the same in the forecasted period as it was before 2009). We found that the total diagnosed chronic HCV population grew from 983,000 to 1.19 million in 2007-2009, with patients born from 1945-1964 accounting for 75.0% of all patients, 83.7% of AdvLD patients, and 79.2% of costs in 2009, indicating that HCV is primarily a disease of the "baby boomer" population. Non-pharmacological costs grew from $7.22 billion to $8.63 billion, with the majority of growth derived from the 60,000 new patients that developed AdvLD in 2007-2009, 91.5% of whom were born between 1945 and 1964. The projection model estimated the total AdvLD population would grow from 195,000 in 2008 to 601,000 in 2015, with 73.5% of new AdvLD cases from patients undiagnosed as of 2008. AdvLD prevalence in patients diagnosed as of 2008 was projected to grow 6.5% annually to 303,000 patients in 2015. These findings suggest that strategies to diagnose and treat HCV-infected patients are urgently needed to increase the likelihood that progression is interrupted, particularly for patients born from 1945-1964.

  5. Investigation of enteric adenovirus and poliovirus removal by coagulation processes and suitability of bacteriophages MS2 and φX174 as surrogates for those viruses.

    Science.gov (United States)

    Shirasaki, N; Matsushita, T; Matsui, Y; Marubayashi, T; Murai, K

    2016-09-01

    We evaluated the removal of enteric adenovirus (AdV) type 40 and poliovirus (PV) type 1 by coagulation, using water samples from 13 water sources for drinking water treatment plants in Japan. The behaviors of two widely accepted enteric virus surrogates, bacteriophages MS2 and φX174, were compared with the behaviors of AdV and PV. Coagulation with polyaluminum chloride (PACl, basicity 1.5) removed AdV and PV from virus-spiked source waters: the infectious AdV and PV removal ratios evaluated by means of a plaque-forming-unit method were 0.1-1.4-log10 and 0.5-2.4-log10, respectively. A nonsulfated high-basicity PACl (basicity 2.1) removed infectious AdV and PV more efficiently than did other commercially available PACls (basicity 1.5-2.1), alum, and ferric chloride. The MS2 removal ratios tended to be larger than those of AdV and PV, partly because of differences in the hydrophobicities of the virus particles and the sensitivity of the virus to the virucidal activity of PACl; the differences in removal ratios were not due to differences in the surface charges of the virus particles. MS2, which was more hydrophobic than the other viruses, was inactivated during coagulation with PACl. Therefore, MS2 does not appear to be an appropriate surrogate for AdV and PV during coagulation. In contrast, because φX174, like AdV and PV, was not inactivated during coagulation, and because the hydrophobicity of φX174 was similar to or somewhat lower than the hydrophobicities of AdV and PV, the φX174 removal ratios tended to be similar to or somewhat smaller than those of the enteric viruses. Therefore, φX174 is a potential conservative surrogate for AdV and PV during coagulation. In summary, the surface hydrophobicity of virus particles and the sensitivity of the virus to the virucidal activity of the coagulant are probably important determinants of the efficiency of virus removal during coagulation.

  6. Current and future disease progression of the chronic HCV population in the United States.

    Directory of Open Access Journals (Sweden)

    Martin Zalesak

    Full Text Available Chronic hepatitis C virus (HCV infection can lead to advanced liver disease (AdvLD, including cirrhosis, decompensated cirrhosis, and liver cancer. The aim of this study was to determine recent historical rates of HCV patient progression to AdvLD and to project AdvLD prevalence through 2015. We first determined total 2008 US chronic HCV prevalence from the National Health and Nutrition Evaluation Surveys. Next, we examined disease progression and associated non-pharmacological costs of diagnosed chronic HCV-infected patients between 2007-2009 in the IMS LifeLink and CMS Medicare claims databases. A projection model was developed to estimate AdvLD population growth through 2015 in patients diagnosed and undiagnosed as of 2008, using the 2007-2009 progression rates to generate a "worst case" projection of the HCV-related AdvLD population (i.e., scenario where HCV treatment is the same in the forecasted period as it was before 2009. We found that the total diagnosed chronic HCV population grew from 983,000 to 1.19 million in 2007-2009, with patients born from 1945-1964 accounting for 75.0% of all patients, 83.7% of AdvLD patients, and 79.2% of costs in 2009, indicating that HCV is primarily a disease of the "baby boomer" population. Non-pharmacological costs grew from $7.22 billion to $8.63 billion, with the majority of growth derived from the 60,000 new patients that developed AdvLD in 2007-2009, 91.5% of whom were born between 1945 and 1964. The projection model estimated the total AdvLD population would grow from 195,000 in 2008 to 601,000 in 2015, with 73.5% of new AdvLD cases from patients undiagnosed as of 2008. AdvLD prevalence in patients diagnosed as of 2008 was projected to grow 6.5% annually to 303,000 patients in 2015. These findings suggest that strategies to diagnose and treat HCV-infected patients are urgently needed to increase the likelihood that progression is interrupted, particularly for patients born from 1945-1964.

  7. Dicty_cDB: CHD848 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available osing malaria and immune antigen for suppressing growth of plasmodium. 58 4e-16 5 BD183625 |BD183625.1 Mater...ial for diagnosing malaria and immune antigen for suppressing growth of plasmodium

  8. Online Real-Time Tribology Failure Detection System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The investigation of the coating friction as a function of time is important to monitor the ball bearing heath. Despite the importance of the subject mater, there is...

  9. Photovoltage versus microprobe sheet resistance measurements on ultrashallow structures

    DEFF Research Database (Denmark)

    Clarysse, T.; Moussa, A.; Parmentier, B.

    2010-01-01

    Earlier work [T. Clarysse , Mater. Sci. Eng., B 114-115, 166 (2004); T. Clarysse , Mater. Res. Soc. Symp. Proc. 912, 197 (2006)] has shown that only few contemporary tools are able to measure reliably (within the international technology roadmap for semiconductors specifications) sheet resistances...... on ultrashallow (sub-50-nm) chemical-vapor-deposited layers [T. Clarysse , Mater. Res. Soc. Symp. Proc. 912, 197 (2006)], especially in the presence of medium/highly doped underlying layers (representative for well/halo implants). Here the authors examine more closely the sheet resistance anomalies which have......-based millisecond anneal). Conventional four-point probe tools fail on almost all of these samples due to excessive probe penetration, whereas in several cases variable probe spacing (using a conventional spreading resistance probe tool) [T. Clarysse , Mater. Sci. Eng. R. 47, 123 (2004)] still gives useful values...

  10. Kristjan Järvi juhatab Pärdi maailmaesiettekannet Viinis / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2008-01-01

    Arvo Pärdi teose "Stabat Mater" segakoori- ja keelpilliorkestriversiooni maailmaesiettekandest 12. juunil Viinis ja dirigent Kristjan Järvi tegemistest. Bariton Lauri Vasar laulmas Hans Werner Henze ooperis "Phaedra" Berliinis, Brüsselis ja Viinis

  11. Novel Approach to the Dark Matter Problem: Primordial Intermediate-Mass Black Holes

    CERN Document Server

    Frampton, Paul H

    2016-01-01

    A discussion at a Scientific American level of the idea that the constituents of the dark mater in galactic halos are primordial intermediate-mass black holes with masses between ten and one hundred thousand times the solar mass.

  12. Regulation of expression of osteoblast transcription factor SATB2 by BMP2 in osteoblastic differentiation of MSCs%MSCs成骨分化中BMP2对成骨转录因子SATB2表达的调控作用

    Institute of Scientific and Technical Information of China (English)

    左炽健; 剌婷; 张宁; 戴尅戎; 张晓玲

    2011-01-01

    目的 探索间充质干细胞(MSCs)成骨分化中骨形态发生蛋白2(BMP2)对成骨转录因子SATB2表达的调控作用.方法 体外培养小鼠间充质细胞系C2C12,腺病毒介导的BMP2 (Adv-BMP2)诱导其向成骨细胞分化,建立并验证C2C12细胞成骨分化细胞模型.Real-Time PCR和Western blotting分别检测C2C12细胞成骨分化过程中经不同浓度Adv-BMP2处理不同时间时SATB2 mRNA和SATB2蛋白表达;以经相应浓度Adv-β-Gal处理细胞作对照.结果 经150 pfu/cell Adv-BMP2处理C2C12细胞5d后,成骨细胞标志基因Ⅰ型胶原,骨唾液酸蛋白和骨钙素表达以及碱性磷酸酶活性均显著增加,MSCs成骨分化模型构建成功.150 pfu/cell Adv-BMP2诱导C2C12细胞成骨分化过程中,SATB2 mRNA和SATB蛋白表达随分化进程而增加;Adv-BMP2浓度为0~225 pfu/cell时,SATB2表达随Adv-BMP2浓度升高而增加.结论BMP2可调控SATB2的表达,从而影响MSCs成骨分化.%Objective To investigate the role of bone morphogenetic protein 2 (BMP2) in the regulation of expression of osteoblast transcription factor SATB2 in osteoblastic differentiation of mesenchymal stem cells ( MSCs). Methods Mesenchymal cell line C2C12 was stimulated by adenovirus-derived BMP2 (Adv-BMP2) for osteoblastic differentiation, and model of osteoblastic differentiation of C2C12 cells was established and verified. Real-Time PCR and Western blotting were employed to detect the expression of SATB2 mRNA and SATB2 protein respectively in osteoblastic differentiation treated by Adv-BMP2 for different time and by Adv-BMP2 of different concentrations. C2CI2 cells treated with Adv-β-Gal were served as controls. Results After treatment by ISO pfu/cell Adv-BMP2 for 5 d, the expression of collagen type I , bone sialoprotein and osteocalcin and the activity of alkaline phosphatase in C2C12 cells significantly increased, and the model of osteoblastic differentiation of C2C12 cells was established. The expression of SATB2 mRNA and

  13. Piezoelectric and Electrostrictive Materials for Transducer Applications. Volume 2

    Science.gov (United States)

    1991-01-31

    34R. E. Newtilism. D. P. Skinner , and L. E. Cross, Mater. Res. Bull. XIII. 525 (1978). J. Mater. Rae.. V%". 5 No 12, Doc 1990 2909 APPENDIX 43 I I I I...technique was accomplished by Gasson and Cockayne. 1 They were able to grow 5mm diameter A12 0 3 , MgAI2 0 4 and other refractory compositions. Burrus and

  14. Cefaleia pós-punção da dura máter

    OpenAIRE

    Veiga, R; Pinheiro, N; Vilaça, MJ; Morais, S; Carmona, C

    2012-01-01

    Apresenta uma revisão da anatomia, fisiopatologia,clinica, diagnóstico e tratamento das cefaleias pos punção da dura mater. Faz uma revisão da casuistica do serviço de anestesiologia em relação a esta entidade clinica e apresenta alguns casos clinicos de cefaleias para diagnóstico diferencial com as cefaleias pós punção da dura mater.

  15. Bulk Nanocrystalline Metals: Review of the Current State of the Art and Future Opportunities for Copper and Copper Alloys

    Science.gov (United States)

    2014-05-13

    C.C. Koch, R.O. Scattergood, K.A. Darling, and J.E. Se- mones , J. Mater. Sci. 43, 7264 (2008). 41. M. Ames, J. Markmann, R. Karos, A. Michels, A...R.O. Scattergood, K.A. Darling, and J.E. Se- mones , J. Mater. Sci. 43 (23–24), (2008). 53. K.A. Darling, B.K. VanLeeuwen, J.E. Semones, C.C. Koch

  16. Ultrastructure Processing and Environmental Stability of Advanced Structural and Electronic Materials

    Science.gov (United States)

    1992-08-31

    Chemical & mechanical be- havior of Bioglass coated alumina. J. Biomed. Mater. Res. REFERENCES 10:503; 1976. 13. Kitsugi. T.; Yamamuro , T.: Nakamura...of Orthopedic Kitsuigi. T.: and Yamamuro . T. Ca. P-rich layer formed on Implants. Williams, D. F, ed.. Boca Ralon:CRC Press: high -strength bloactive...Biomedical Maters. Res., 1980, 14, 55-64. 14. Kokubo, T. In Handbook of Bioactive Ceramics, Vol. I, Yamamuro , T., Hench, L. L. and Wilson, J., eds

  17. Increased dendritic spine density and tau expression are associated with individual differences in steroidal regulation of male sexual behavior.

    Directory of Open Access Journals (Sweden)

    Pranay Bharadwaj

    Full Text Available Male sexual behavior (MSB is modulated by gonadal steroids, yet this relationship is highly variable across species and between individuals. A significant percentage (~30% of B6D2F1 hybrid male mice demonstrate MSB after long-term orchidectomy (herein after referred to as "maters", providing an opportunity to examine the mechanisms that underlie individual differences in steroidal regulation of MSB. Use of gene expression arrays comparing maters and non-maters has provided a first pass look at the genetic underpinnings of steroid-independent MSB. Surprisingly, of the ~500 genes in the medial preoptic area (MPOA that differed between maters and non-maters, no steroid hormone or receptor genes were differentially expressed between the two groups. Interestingly, best known for their association with Alzheimer's disease, amyloid precursor protein (APP and the microtubule-associated protein tau (MAPT were elevated in maters. Increased levels of their protein products (APP and tau in their non-pathological states have been implicated in cell survival, neuroprotection, and supporting synaptic integrity. Here we tested transgenic mice that overexpress tau and found facilitated mounting and intromission behavior after long-term orchidectomy relative to littermate controls. In addition, levels of synaptophysin and spinophilin, proteins generally enriched in synapses and dendritic spines respectively, were elevated in the MPOA of maters. Dendritic morphology was also assessed in Golgi-impregnated brains of orchidectomized B6D2F1 males, and hybrid maters exhibited greater dendritic spine density in MPOA neurons. In sum, we show for the first time that retention of MSB in the absence of steroids is correlated with morphological differences in neurons.

  18. Clinical importance of the middle meningeal artery.

    Science.gov (United States)

    Chmielewski, Przemyslaw; Skrzat, Janusz; Walocha, Jerzy

    2013-01-01

    Middle meningeal artery (MMA)is an important branch which supplies among others cranial dura mater. It directly attaches to the cranial bones (is incorporated into periosteal layer of dura mater), favors common injuries in course of head trauma. This review describes available data on the MMA considering its varability, or treats specific diseases or injuries where the course of MMA may have clinical impact.

  19. Antiviral activity of Plantago major extracts and related compounds in vitro.

    Science.gov (United States)

    Chiang, L C; Chiang, W; Chang, M Y; Ng, L T; Lin, C C

    2002-07-01

    Plantago major L., a popular traditional Chinese medicine, has long been used for treating various diseases varying from cold to viral hepatitis. The aim of present study was to examine the antiviral activity of aqueous extract and pure compounds of P. major. Studies were conducted on a series of viruses, namely herpesviruses (HSV-1, HSV-2) and adenoviruses (ADV-3, ADV-8, ADV-11). The antiviral activity of EC50 was defined as the concentration achieved 50% cyto-protection against virus infection and the selectivity index (SI) was determined by the ratio of CC50 (concentration of 50% cellular cytotoxicity) to EC50. Results showed that aqueous extract of P. major possessed only a slight anti-herpes virus activity. In contrast, certain pure compounds belonging to the five different classes of chemicals found in extracts of this plant exhibited potent antiviral activity. Among them, caffeic acid exhibited the strongest activity against HSV-1 (EC50=15.3 microg/ml, SI=671), HSV-2 (EC50=87.3 microg/ml, SI=118) and ADV-3 (EC50=14.2 microg/ml, SI=727), whereas chlorogenic acid possessed the strongest anti-ADV-11 (EC50=13.3 microg/ml, SI=301) activity. The present study concludes that pure compounds of P. major, which possess antiviral activities are mainly derived from the phenolic compounds, especially caffeic acid. Its mode of action against HSV-2 and ADV-3 was found to be at multiplication stages (postinfection of HSV-1: 0-12 h; ADV-3: 0-2 h), and with SI values greater than 400, suggesting the potential use of this compound for treatment of the infection by these two viruses.

  20. EFFECTS OF IN VIVO GENE TRANSDUCTION OF ANTI-MDR1 RIBOZYME IN COMBINATION WITH CHEMOTHERAPY ON MULTIDRUG-RESISTANT HUMAN LYMPHOMA GROWTH IN MICE

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Objective: To study the effect of adenovirus- mediated transfer of anti-MDR1 ribozyme on the reversal of multidrug resistant (MDR) phenotype of P-glycoprotein (P-gp)-positive Daudi human Burkitt lymphoma both in vitro and in vivo. Methods: A recombinant adenovirus expressing 196Rz (Adv-196Rz) was developed and functionally evaluated. SCID mice inoculated subcutaneously (s.c.) with 5×106 Daudi/MDR20 cells were locally treated with Adv-196Rz or mock virus (Adv-Mock) at the multiplicity of infection (MOI) of 400 PFU once a day for 3 consecutive days. Then the mice were intraperitoneally (i.p.) administrated with vincristine (VCR) 450ng/g for 5 consecutive days. Results: In vitro employment of Adv-196Rz was able to interrupt MDR1 transcription, to inhibit P-gp expression and to restore drug sensitivity to VCR of Daudi/MDR20 cells. In vivo, 87.5% (7/8) of Daudi/MDR20-inoculated mice treated with Adv-Mock+ VCR developed palpable tumor by the 6th week and died or were sacrificed (because of tumor weight > 10% of body weight) by the 11th week. In contrast, among 9 Daudi/MDR20-inoculated mice treated with Adv-196Rz + VCR, only 3 developed tumor by the 11th, 13th and 14th week, respectively. 66.7% of mice survived >120 days in tumor-free. The survival difference between the two groups was very significant (P<0.01). Conclusion: Adenovirus- mediated Transfer of 196Rz can revert drug resistance of MDR tumor cells both in vitro and in vivo. Adv-196Rz may prove useful as an adjuvant in the chemotherapy of P-gp mediated MDR human tumors.

  1. Microscopic morphology and histology of the human meninges.

    Science.gov (United States)

    Weller, R O

    2005-03-01

    The meninges comprise the dura mater and the leptomeninges (arachnoid and pia mater). Dura forms an outer endosteal layer related to the bones of the skull and spine and an inner layer closely applied to the arachnoid mater. Leptomeninges have multiple functions and anatomical relationships. The outer parietal layer of arachnoid is impermeable to CSF due to tight intercellular junctions; elsewhere leptomeningeal cells form demosomes and gap junctions. Trabeculae of leptomeninges compartmentalize the subarachnoid space and join the pia to arachnoid mater. In bacterial meningitis leptomeningeal cells secrete cytokines. Pia mater is reflected from the surface of the brain and spinal cord onto arteries and veins, thus separating the subarachnoid space from the brain and cord. A sheath of leptomeninges accompanies arteries into the brain and is related to the pathways for the drainage of interstitial fluid that play a role in inflammatory responses in the brain and appear to be blocked by amyloid-beta in Alzheimer's disease. Specialised leptomeningeal cells in the stroma of the choroid plexus form collagen whorls that become calcified with age. Leptomeningeal cells also form channels in the core and apical cap of arachnoid granulations for the drainage of CSF into venous sinuses. In the spine, leptomeninges form highly perforated intermediate sheets of arachnoid and delicate ligaments that compartmentalize the subarachnoid space; dentate ligaments anchor subpial collagen to the dura mater and stabilize the spinal cord. Despite the multiple anatomical arrangements and physiological functions, leptomeningeal cells retain many histological features that are similar from site to site.

  2. A dor durante a punção do canal vertebral e sua relação com a inervação do ligamento amarelo, da dura-máter e do ligamento longitudinal posterior El dolor durante la punción del canal vertebral y su relación con la inervación del ligamento amarillo, de la dura-máter y del ligamento longitudinal posterior Pain during spinal canal puncture and its relationship with ligamentum flavum, dura-mater and posterior longitudinal ligament innervation

    OpenAIRE

    2004-01-01

    JUSTIFICATIVA E OBJETIVOS: A dor durante a punção raquidiana é um sinal de alarme, indicando que a ponta da agulha tocou numa estrutura nervosa. Por este motivo, se o paciente acusar dor durante a punção, é obrigatória a interrupção da técnica. A solução anestésica não deverá ser injetada para evitar uma possível lesão de raiz nervosa ou da medula espinhal. Deve-se recuar a agulha e mudar sua direção antes de novo avanço. O relato de dor é totalmente impossível se o paciente estiver adormecid...

  3. 国外文献速报

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Hattel J H,Thorborg J,Pryds N H.液滴尺寸分布 对喷射成型过程气体温度的影响(英).Scr.mater.,1999,42(2):145~150 020306 Eden T J.喷射成型生产的铝合金(英).Ind.Heat,20 00,60(1):45~48 020307 Suzzani R.铸造工厂的快速成型的应用(意).Fonder ia,1999,48(11/12):48~51 020308 山村 英明,藤健 彦,原田宽.用铸型内电磁闸控制 夹杂物品质的最佳磁场强度(日).材料とぺロセス,2000,13(1):177 020309 比技 敏昭.使用注目素材的成型和金属型:镁合金 的射出成型技术和金属型(日).型技术,2000,15(2):30~35 020310 Froes F H,Ward-Close C M,Mccormick P G.轻金 属材料的合成及加工(英).Synth.Lightweight Met.,1999(3):3~11 020311 Matsuura K,Jinmon H,Kudou M.Ni-Al-Fe三元金 属间化合物合金的反应铸造(英).ISIJ Int.,2000,40(2):161~166 020312 Matsuura K,Jinmon H,Kudou M.利用反应铸造制造N iAl/被覆钢(英).ISIJ Int.,2000,40(2):167~171 020313 Meulenberg W A,Rothe H,Sahm P R.失蜡铸造陶瓷 壳型的制造和研究(英).Ceram.Forum.Int.,2000,77(4):30~35 020314 Nolte M.轻金属的砂型和重力金属型铸造(Ⅲ):熔 化、铸造、凝固(德).Giesseriei,2000,87(3):89~100 020315 Kaufman H,Uggowitzer P J,Wobussek H.关于NRC半 固态铸造工艺的冶金和加工(法).Hommes Fonderie,2000(303):36~40 020316 Goowin F,Garreau G H.氧使获得无气孔压铸件变为 可能(法).Hommes Fonderie,2000(303):34~35 生产设备及检测仪器仪表 020401 Rodriguez J M,Meza A.对铜管连续铸造中凝固前沿 控制的评注(英).J.Mater.Process Technol.,1999,96(1/3):42~47 020402 Poulsen E,Chinnis W,Mede M.钛的冷炉床熔炼技术 的进步(英).Ind.Heat,2000,67(1):49~51 020403 北冈 山治.最新铝溶液质量计测技术(日).铸造工学 ,2000,72(1):66~72 020404 Wu M,Augthun M,Sahm P R.用数值模拟联合快速成 形和失蜡铸造,钛假牙的相关结果(英).Adv.Eng.Mater.,2000,2(7):431

  4. Analysis of evolution and virological characteristics of rtI233V mutations in the hepatitis B virus reverse transcriptase domain

    Directory of Open Access Journals (Sweden)

    Xiao-ling YE

    2015-04-01

    Full Text Available Objective To analyze the evolution of rtI233V mutation in the reverse transcriptase domain of hepatitis B virus (HBV and its association with adefovir dipivoxil (ADV resistance. Methods The rate of detection of rtI233V mutation in 9830 patients with chronic HBV infection was analyzed. HBV reverse transcriptase genes isolated from serial serum samples of two patients were amplified by nested PCR, and clonal sequencing (>20 clones/sample was performed to analyze the evolution of rtI233V mutations. The replica of pTriEx-HBV1.1 vectors harboring wild-type and mutant strains (rtI233V, rtN236T, rtI233V+rtN236T were respectively constructed and transiently transfected into HepG2 cells. Media containing serial concentrations of lamivudine (LAM, ADV, entecavir (ETV, or tenofovir (TDF were used to treat the cells. Then HBV DNA in the supernatants was quantitatively determined by real-time PCR in order to analyze HBV mutants' replication competence and phenotypic characteristics under the drug pressures. Results The detection rate of rtI233V mutation in 9830 nucleos(tide analogues-treated patients was 0.28% (28/9830, including 0.19% (19 patients with rtI233V individual mutation and 0.09% (9 patients with rtI233V mutation combining with rtN236T or other mutations. All of the patients had rtI233V had ADV exposure history: 16 (57.1% of them received ADV monotherapy for over six months, and 12(42.9% of them received ADV combined sequential therapy for over 12 months. Replication competence and phenotypic resistance analysis showed rtI233V and wild-type strains had similar viral replication competence, while rtN236T exhibited significantly lower replication competence compared with wild-type strains. rtI233V strains remained sensitive to LAM, ADV, ETV, and TDF and showed little influence on drug resistance when combined with rtN236T, but it showed ability to restore the defected replication capacity of rtN236T strains. Conclusions  The rtI233V mutation

  5. Binding sensitivity of adefovir to the polymerase from different genotypes of HBV: molecular modeling,docking and dynamics simulation studies

    Institute of Scientific and Technical Information of China (English)

    Jing LI; Yun DU; Xian LIU; Qian-cheng SHEN; Ai-long HUANG; Ming-yue ZHENG; Xiao-min LUO; Hua-liang JIANG

    2013-01-01

    Aim: To investigate the molecular mechanisms underlying the influence of DNA polymerase from different genotypes of hepatitis B virus (HBV) on the binding affinity of adefovir (ADV).Methods: Computational approaches,including homology modeling,docking,MD simulation and MM/PBSA free energy analyses were used.Results: Sequence analyses revealed that residue 238 near the binding pocket was not only a polymorphic site but also a genotypespecific site (His238 in genotype B; Asn238 in genotype C).The calculated binding free-energy supported the hypothesis that the polymerase from HBV genotype C was more sensitive to ADV than that from genotype B.By using MD simulation trajectory analysis,binding free energy decomposition and alanine scanning,some energy variation in the residues around the binding pocket was observed.Both the alanine mutations at residues 236 and 238 led to an increase of the energy difference between genotypes C and B (△△Gc-B),suggesting that these residues contributed to the genotype-associated antiviral variability with regard to the interaction with ADV.Conclusion: The results support the hypothesis that the HBV genotype C polymerase is more sensitive to ADV than that from genotype B.Moreover,residue N236 and the polymorphic site 238 play important roles in contributing to the higher sensitivity of genotype C over B in the interaction with ADV.

  6. Characterization of deoxyribonucleic acid from cells infected with Aleutian disease virus

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, E.C.; Ramos, L.; Kenyon, A.J.

    1983-07-01

    Viral DNA was extracted from Crandell feline kidney (CRFK) cells infected with Aleutian disease virus (ADV) and labeled with (/sup 3/H)thymidine. The sedimentation coefficient in alkaline sucrose gradients was 16S corresponding to a molecular weight of 1.5 X 10(6). The buoyant densities of DNA from infected and control cells were determined by isopyknic sedimentation in CsCl and NaI gradients. Two additional peaks of (/sup 3/H)DNA were found in infected cells, but not in control cell extracts. Fractionation of this DNA on hydroxylapatite indicated that the new peaks represented a single-stranded component, density 1.728 g/cm3, and a double-stranded component, presumed to be a viral replicative intermediate, density 1.718 g/cm3. The target antigen formation in CRFK cells was measured by gamma-irradiation of ADV and assayed for focus formation. The calculated size of ADV based on these measurements was 1.1 X 10(6). The H-1 parvovirus also was shown to have a size of 1.5 X 10(6) daltons for both antigen and plaque formation. The data indicated similarities existed between ADV and other autonomously replicating parvoviruses in most properties, except that less-than-unit length genome of ADV may be transcribed.

  7. Outcomes of early administration of cidofovir in non-immunocompromised patients with severe adenovirus pneumonia.

    Directory of Open Access Journals (Sweden)

    Se Jin Kim

    Full Text Available The benefits of treatment with antiviral therapy for severe adenovirus (AdV pneumonia are not well established. We described the clinical characteristics and treatment outcomes of early cidofovir treatment of severe AdV pneumonia in non-immunocompromised patients. We retrospectively reviewed the medical records of all patients diagnosed with severe AdV pneumonia between 2012 and 2014. A total of seven non-immunocompromised patients with severe AdV pneumonia were identified, and all isolates typed (n = 6 were human AdV-B55. All patients had progressive respiratory failure with lobar consolidation with or without patchy ground glass opacity. Three patients required vasopressors and mechanical ventilation. All patients had abnormal laboratory findings including: leukopenia, thrombocytopenia, or elevated liver enzymes. After admission, all patients received antiviral therapy with cidofovir, and the median time from admission to cidofovir administration was 48 h and median the time from onset of symptoms to cidofovir administration was 7.1 days. After cidofovir administration, complete symptomatic improvement occurred after a median of 12 days and radiographic resolution occurred after a median of 21 days. Consequently, all patients completely improved without complications. Our data suggest that early administration of cidofovir in the course of treatment for respiratory failure as a result of AdV pneumonia in non-immunocompromised patients could be a treatment strategy worth considering, especially in cases of HAdV-55 infection.

  8. Outcomes of early administration of cidofovir in non-immunocompromised patients with severe adenovirus pneumonia.

    Science.gov (United States)

    Kim, Se Jin; Kim, Kang; Park, Sung Bum; Hong, Duck Jin; Jhun, Byung Woo

    2015-01-01

    The benefits of treatment with antiviral therapy for severe adenovirus (AdV) pneumonia are not well established. We described the clinical characteristics and treatment outcomes of early cidofovir treatment of severe AdV pneumonia in non-immunocompromised patients. We retrospectively reviewed the medical records of all patients diagnosed with severe AdV pneumonia between 2012 and 2014. A total of seven non-immunocompromised patients with severe AdV pneumonia were identified, and all isolates typed (n = 6) were human AdV-B55. All patients had progressive respiratory failure with lobar consolidation with or without patchy ground glass opacity. Three patients required vasopressors and mechanical ventilation. All patients had abnormal laboratory findings including: leukopenia, thrombocytopenia, or elevated liver enzymes. After admission, all patients received antiviral therapy with cidofovir, and the median time from admission to cidofovir administration was 48 h and median the time from onset of symptoms to cidofovir administration was 7.1 days. After cidofovir administration, complete symptomatic improvement occurred after a median of 12 days and radiographic resolution occurred after a median of 21 days. Consequently, all patients completely improved without complications. Our data suggest that early administration of cidofovir in the course of treatment for respiratory failure as a result of AdV pneumonia in non-immunocompromised patients could be a treatment strategy worth considering, especially in cases of HAdV-55 infection.

  9. Molecular characterization, phylogeny analysis and pathogenicity of a Muscovy duck adenovirus strain isolated in China in 2014

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xinheng [College of Animal Science, South China Agricultural University & Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou 510642 (China); Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong 510642 (China); South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou 510642 (China); Zhong, Yangjin; Zhou, Zhenhai; Liu, Yang [College of Animal Science, South China Agricultural University & Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou 510642 (China); Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong 510642 (China); Zhang, Huanmin [USDA, Agriculture Research Service, Avian Disease and Oncology Laboratory, East Lansing, MI 48823 (United States); Chen, Feng [College of Animal Science, South China Agricultural University & Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou 510642 (China); Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong 510642 (China); Chen, Weiguo [College of Animal Science, South China Agricultural University & Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou 510642 (China); Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong 510642 (China); South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou 510642 (China); Xie, Qingmei, E-mail: qmx@scau.edu.cn [College of Animal Science, South China Agricultural University & Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou 510642 (China); Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong 510642 (China); South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou 510642 (China)

    2016-06-15

    This study aimed to characterize a novel adenovirus (AdV) isolated from diseased Muscovy ducks in China. After the AdV was successfully propagated in duck embryo fibroblasts, the morphological and physicochemical properties of the virions were studied by electron microscopy and different tests. The results of the analyses were in conformity with AdV properties. The full genome sequence was determined and analyzed. The new isolate (named CH-GD-12-2014) shared over 91% sequence identity with duck AdV-2 representing the species Duck aviadenovirus B. The most important distinguishing feature between the two DAdV strains was the presence of a second fiber gene in the Chinese isolate. Phylogeny reconstruction confirmed the affiliation of the virus with goose and duck AdVs in the genus Aviadenovirus. Experimental infection resulted in embryo death, and intramuscular inoculation provoked morbidity and mortality among ducks and chickens. - Highlights: • A duck adenovirus type 3 was isolated and the complete genome of DAdV-3 was obtained. • Physicochemical properties and electron microscopy were researched. • Pathogenicity of duck adenovirus type 3 was researched.

  10. Lamivudine plus adefovir is a good option for chronic hepatitis B patients with viral relapse after cessation of lamivudine treatment

    Directory of Open Access Journals (Sweden)

    Zhang Yong

    2011-08-01

    Full Text Available Abstract Aim Currently, there is no consensus on the retreatment recommendation of chronic hepatitis B (CHB patients with viral rebound after cessation of treatment. In the search of reasonable treatment, we compared the efficacy and safety of adefovir (ADV plus lamivudine (LAM and LAM alone for the retreatment of patients with viral relapse but without genotypic resistance after cessation of LAM. Methods This is a prospective controlled study, and a total of 53 hepatitis B e antigen (HBeAg-positive patients with viral rebound but without resistance were received either LAM plus ADV or LAM alone treatment. Results After 1-year treatment, more patients who received LAM plus ADV than those who received LAM alone had ALT normalization (84% versus 53.6%, P = 0.018 or HBV DNA levels below 1000 copies/mL (80% versus 42.9%, P Conclusions Patients treated with LAM plus ADV exhibited significantly greater virological, biochemical and serological responses compared with LAM alone. These data suggested that combination of LAM plus ADV would be a good option for the retreatment of CHB patients with viral relapse after cessation of LAM.

  11. Mechanical Design and Development of TES Bolometer Detector Arrays for the Advanced ACTPol Experiment

    Science.gov (United States)

    Ward, Jonathan T.; Austermann, Jason; Beall, James A.; Choi, Steve K.; Crowley, Kevin T.; Devlin, Mark J.; Duff, Shannon M.; Gallardo, Patricio M.; Henderson, Shawn W.; Ho, Shuay-Pwu Patty; Hilton, Gene; Hubmayr, Johannes; Khavari, Niloufar; Klein, Jeffrey; Koopman, Brian J.; Li, Dale; McMahon, Jeffrey; Mumby, Grace; Nati, Federico; Wollack, Edward J.

    2016-01-01

    The next generation Advanced ACTPol (AdvACT) experiment is currently underway and will consist of four Transition Edge Sensor (TES) bolometer arrays, with three operating together, totaling 5800 detectors on the sky. Building on experience gained with the ACTPol detector arrays, AdvACT will utilize various new technologies, including 150 mm detector wafers equipped with multichroic pixels, allowing for a more densely packed focal plane. Each set of detectors includes a feedhorn array of stacked silicon wafers which form a spline pro le leading to each pixel. This is then followed by a waveguide interface plate, detector wafer, back short cavity plate, and backshort cap. Each array is housed in a custom designed structure manufactured from high purity copper and then gold plated. In addition to the detector array assembly, the array package also encloses cryogenic readout electronics. We present the full mechanical design of the AdvACT high frequency (HF) detector array package along with a detailed look at the detector array stack assemblies. This experiment will also make use of extensive hardware and software previously developed for ACT, which will be modi ed to incorporate the new AdvACT instruments. Therefore, we discuss the integration of all AdvACT arrays with pre-existing ACTPol infrastructure.

  12. Clinical and epidemiological aspects related to the detection of adenovirus or respiratory syncytial virus in infants hospitalized for acute lower respiratory tract infection

    Directory of Open Access Journals (Sweden)

    Eduardo A. Ferone

    2014-01-01

    Full Text Available OBJECTIVE: To characterize and compare clinical, epidemiological, and laboratory aspects ofinfants with acute lower respiratory infection (ALRI associated with the detection of adenovirus(ADV or respiratory syncytial virus (RSV. METHODS: A preliminary respiratory infection surveillance study collected samples of nasopharyngeal aspirate (NPA for viral research, linked to the completion of a standard protocol, from children younger than two years admitted to a university hospital with ALRI, between March of 2008 and August of 2011. Polymerase chain reaction (PCR was used for eight viruses: ADV, RSV, metapneumovirus, Parainfluenza 1, 2, and 3, and Influenza A and B. Cases with NPA collectedduring the first 24 hours of admission, negative results of blood culture, and exclusive detection of ADV (Gadv group or RSV (Grsv group were selected for comparisons. RESULTS: The preliminary study included collection of 1,121 samples of NPA, 813 collected in thefirst 24 hours of admission, of which 50.3% were positive for at least one virus; RSV was identifiedin 27.3% of cases surveyed, and ADV was identified in 15.8%. Among the aspects analyzed inthe Gadv (n = 58 and Grsv (n = 134 groups, the following are noteworthy: the higher meanage, more frequent prescription of antibiotics, and the highest median of total white blood cellcount and C-reactive protein values in Gadv. CONCLUSIONS: PCR can detect persistent/latent forms of ADV, an aspect to be considered wheninterpreting results. Additional studies with quantitative diagnostic techniques could elucidatethe importance of the high frequency observed.

  13. Male predominance among Japanese adult patients with late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation.

    Science.gov (United States)

    Asano, Y; Kanda, Y; Ogawa, N; Sakata-Yanagimoto, M; Nakagawa, M; Kawazu, M; Goyama, S; Kandabashi, K; Izutsu, K; Imai, Y; Hangaishi, A; Kurokawa, M; Tsujino, S; Ogawa, S; Aoki, K; Chiba, S; Motokura, T; Hirai, H

    2003-12-01

    Late-onset hemorrhagic cystitis (LHC) after hematopoietic stem cell transplantation (HSCT) is mainly caused by viral infections. We retrospectively analyzed the records of 141 Japanese adult patients who underwent a first allogeneic HSCT from 1995 to 2002. In all, 19 patients developed LHC a median of 51 days after HSCT. Adenovirus (AdV) was detected in the urine of 10 LHC patients, of whom eight had AdV type 11. Five of the six available serum samples from these patients were also positive for AdV type 11, but the detection of AdV in serum was not associated with a worse outcome. Male sex and the development of grade II-IV acute graft-versus-host disease were identified as independent significant risk factors for LHC. Male predominance was detected in LHC after HSCT, as has been previously shown in children with AdV-induced acute HC. The detection of AdV DNA in serum did not predict a poor outcome.

  14. Cyclin C stimulates β-cell proliferation in rat and human pancreatic β-cells

    OpenAIRE

    2015-01-01

    Activation of pancreatic β-cell proliferation has been proposed as an approach to replace reduced functional β-cell mass in diabetes. Quiescent fibroblasts exit from G0 (quiescence) to G1 through pRb phosphorylation mediated by cyclin C/cdk3 complexes. Overexpression of cyclin D1, D2, D3, or cyclin E induces pancreatic β-cell proliferation. We hypothesized that cyclin C overexpression would induce β-cell proliferation through G0 exit, thus being a potential therapeutic target to recover funct...

  15. Higher dimensional nonclassical eigenvalue asymptotics

    Science.gov (United States)

    Camus, Brice; Rautenberg, Nils

    2015-02-01

    In this article, we extend Simon's construction and results [B. Simon, J. Funct. Anal. 53(1), 84-98 (1983)] for leading order eigenvalue asymptotics to n-dimensional Schrödinger operators with non-confining potentials given by Hn α = - Δ + ∏ i = 1 n |x i| α i on ℝn (n > 2), α ≔ ( α 1 , … , α n ) ∈ ( R+ ∗ ) n . We apply the results to also derive the leading order spectral asymptotics in the case of the Dirichlet Laplacian -ΔD on domains Ωn α = { x ∈ R n : ∏ j = 1 n }x j| /α j α n < 1 } .

  16. Asymptotic Spreading Fastened by Inter-Specific Coupled Nonlinearities: a Cooperative System

    CERN Document Server

    Lin, Guo

    2010-01-01

    This paper is concerned with the asymptotic spreading of a Lotka-Volterra cooperative system. Utilizing the theory developed by Berestycki et al. [Asymptotic spreading in heterogeneous diffusive excitable media, J. Funct. Anal. \\textbf{255} (2008), 2146-2189] for nonautonomous scalar equations, the lower bounds of spreading speeds of unknown functions formulated by a coupled system are estimated. Our results imply that the asymptotic spreading of one species can be significantly fastened by introducing a mutual species, which indicates the role of cooperation described by the coupled nonlinearities.

  17. Affine and quasi-affine frames for rational dilations

    DEFF Research Database (Denmark)

    Bownik, Marcin; Lemvig, Jakob

    2011-01-01

    , the corresponding family of quasi-affine systems are frames with uniform frame bounds. We also prove a similar equivalence result between pairs of dual affine frames and dual quasi-affine frames. Finally, we uncover some fundamental differences between the integer and rational settings by exhibiting an example......In this paper we extend the investigation of quasi-affine systems, which were originally introduced by Ron and Shen [J. Funct. Anal. 148 (1997), 408-447] for integer, expansive dilations, to the class of rational, expansive dilations. We show that an affine system is a frame if, and only if...

  18. Fans and their applications in General Topology, Functional Analysis and Topological Algebra

    OpenAIRE

    Banakh, Taras

    2016-01-01

    A family of closed subsets of a topological space $X$ is called a (strict) $Cld$-fan in $X$ if this family is (strictly) compact-finite but not locally finite in $X$. Applications of (strict) $Cld$-fans are based on a simple observation that $k$-spaces contain no $Cld$-fan and Ascoli spaces contain no strict $Cld$-fan. In this paper we develop the machinery of (strict) fans and apply it to detecting the $k$-space and Ascoli properties in spaces that naturally appear in General Topology, Funct...

  19. Lectures on ordinary differential equations

    CERN Document Server

    Hurewicz, Witold

    2014-01-01

    Hailed by The American Mathematical Monthly as ""a rigorous and lively introduction,"" this text explores a topic of perennial interest in mathematics. The author, a distinguished mathematician and formulator of the Hurewicz theorem, presents a clear and lucid treatment that emphasizes geometric methods. Topics include first-order scalar and vector equations, basic properties of linear vector equations, and two-dimensional nonlinear autonomous systems. Suitable for senior mathematics students, the text begins with an examination of differential equations of the first order in one unknown funct

  20. A Framework for Coxeter Spectral Classification of Finite Posets and Their Mesh Geometries of Roots

    OpenAIRE

    2013-01-01

    Following our paper [Linear Algebra Appl. 433(2010), 699–717], we present a framework and computational tools for the Coxeter spectral classification of finite posets J≡(J,⪯). One of the main motivations for the study is an application of matrix representations of posets in representation theory explained by Drozd [Funct. Anal. Appl. 8(1974), 219–225]. We are mainly interested in a Coxeter spectral classification of posets J such that the symmetric Gram matrix GJ:=(1/2)[CJ+CJtr]∈J(ℚ) is posi...

  1. Hacia una psicología social comunitaria

    OpenAIRE

    Gerardo Marín

    1980-01-01

    Either as a functíon of the críses in social psychology or as function of the needs for relevance in the area, contemporary social psychology is seen as moving into a "comunity social psychology". In this sense the ocial psychologist is ínterested in applying social-psychological knowledge in order to build from within thecommtinity. The role of the community social psychologist is seen as (a) measuring the community´s needs, (b) designíng the intervantíon that will produce ...

  2. Hacia una psicología social comunitaria

    Directory of Open Access Journals (Sweden)

    Gerardo Marín

    1980-01-01

    Full Text Available Either as a functíon of the críses in social psychology or as function of the needs for relevance in the area, contemporary social psychology is seen as moving into a "comunity social psychology". In this sense the ocial psychologist is ínterested in applying social-psychological knowledge in order to build from within thecommtinity. The role of the community social psychologist is seen as (a measuring the community´s needs, (b designíng the intervantíon that will produce social change, and (e evaluating the results of the intervention.

  3. Being in a Virtual World

    DEFF Research Database (Denmark)

    Walther-Hansen, Mads; Grimshaw, Mark

    2016-01-01

    We present a theoretical framework by which virtual world sound designers may work towards the attainment of presence. Drawing on the study of cognitive metaphors and the view that sound is an emergent perception we offer an account of the environment as a salient and dynamic construct that funct......We present a theoretical framework by which virtual world sound designers may work towards the attainment of presence. Drawing on the study of cognitive metaphors and the view that sound is an emergent perception we offer an account of the environment as a salient and dynamic construct...

  4. Fabrication of Unidirectional Fiber Reinforced 6061 Aluminum Alloy Using High Pressure Squeeze Casting

    Science.gov (United States)

    1988-12-01

    soiidfication front as a funct:on of t:me. Suoerim csea cni t2s ine are ooin:s tlat reoresent t",e exact solution at the corresoonaing t:mes as cotainea from the...Bomoay, (1981). Nomoto, M., "Mechanical Properties of Squeeze Castings in Al- Cu Alloys," Journal Japan Institute Light Metals, Vol. 30 (1980), pp 212-216...5. KaneKo, Y., Murakami, H., Kuroda, K. and Nagazaki, S., "Squeeze Casting of Aluminum," Foundry Trade Journal , Vol. 148 (1980), pp 397-411. 6

  5. Extrapolation from , vector-valued inequalities and applications in the Schrödinger settings

    Science.gov (United States)

    Tang, Lin

    2014-04-01

    In this paper, we generalize the A ∞ extrapolation theorem ( Cruz-Uribe-Martell-Pérez, Extrapolation from A ∞ weights and applications, J. Funct. Anal. 213 (2004), 412-439) and the A p extrapolation theorem of Rubio de Francia to Schrödinger settings. In addition, we also establish weighted vector-valued inequalities for Schrödinger-type maximal operators by using weights belonging to which includes A p . As applications, we establish weighted vector-valued inequalities for some Schrödinger-type operators.

  6. Assessment of Sensor Technologies for Advanced Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Korsah, Kofi [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ramuhalli, Pradeep [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Vlim, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Kisner, Roger A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Britton, Jr, Charles L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wootan, D. W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Anheier, Jr, N. C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Diaz, A. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hirt, E. H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chien, H. T. [Argonne National Lab. (ANL), Argonne, IL (United States); Sheen, S. [Argonne National Lab. (ANL), Argonne, IL (United States); Bakhtiari, Sasan [Argonne National Lab. (ANL), Argonne, IL (United States); Gopalsami, S. [Argonne National Lab. (ANL), Argonne, IL (United States); Heifetz, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Tam, S. W. [Argonne National Lab. (ANL), Argonne, IL (United States); Park, Y. [Argonne National Lab. (ANL), Argonne, IL (United States); Upadhyaya, B. R. [Univ. of Tennessee, Knoxville, TN (United States); Stanford, A. [Univ. of Tennessee, Knoxville, TN (United States)

    2016-10-01

    Sensors and measurement technologies provide information on processes, support operations and provide indications of component health. They are therefore crucial to plant operations and to commercialization of advanced reactors (AdvRx). This report, developed by a three-laboratory team consisting of Argonne National Laboratory (ANL), Oak Ridge National Laboratory (ORNL) and Pacific Northwest National Laboratory (PNNL), provides an assessment of sensor technologies and a determination of measurement needs for AdvRx. It provides the technical basis for identifying and prioritizing research targets within the instrumentation and control (I&C) Technology Area under the Department of Energy’s (DOE’s) Advanced Reactor Technology (ART) program and contributes to the design and implementation of AdvRx concepts.

  7. Coating with spermine-pullulan polymer enhances adenoviral transduction of mesenchymal stem cells

    Science.gov (United States)

    Wan, Li; Yao, Xinglei; Faiola, Francesco; Liu, Bojun; Zhang, Tianyuan; Tabata, Yasuhiko; Mizuguchi, Hiroyuki; Nakagawa, Shinsaku; Gao, Jian-Qing; Zhao, Robert Chunhua

    2016-01-01

    Mesenchymal stem cells (MSCs) are adult stem cells with multilineage potential, which makes them attractive tools for regenerative medicine applications. Efficient gene transfer into MSCs is essential not only for basic research in developmental biology but also for therapeutic applications involving gene-modification in regenerative medicine. Adenovirus vectors (Advs) can efficiently and transiently introduce an exogenous gene into many cell types via their primary receptors, the coxsackievirus and adenovirus receptors, but not into MSCs, which are deficient in coxsackievirus and adenovirus receptors expression. To overcome this problem, we developed an Adv coated with a spermine-pullulan (SP) cationic polymer and investigated its physicochemical properties and internalization mechanisms. We demonstrated that the SP coating could enhance adenoviral transduction of MSCs without detectable cytotoxicity or effects on differentiation. Our results argue in favor of the potentiality of the SP-coated Adv as a prototype vector for efficient and safe transduction of MSCs. PMID:28008251

  8. Mechanical design and development of TES bolometer detector arrays for the Advanced ACTPol experiment

    CERN Document Server

    Ward, Jonathan T; Beall, James A; Choi, Steve K; Crowley, Kevin T; Devlin, Mark J; Duff, Shannon M; Gallardo, Patricio M; Henderson, Shawn W; Ho, Shuay-Pwu Patty; Hilton, Gene; Hubmayr, Johannes; Khavari, Niloufar; Klein, Jeffrey; Koopman, Brian J; Li, Dale; McMahon, Jeffrey; Mumby, Grace; Nati, Federico; Niemack, Michael D; Page, Lyman A; Salatino, Maria; Schillaci, Alessandro; Schmitt, Benjamin L; Simon, Sara M; Staggs, Suzanne T; Thornton, Robert; Ullom, Joel N; Vavagiakis, Eve M; Wollack, Edward J

    2016-01-01

    The next generation Advanced ACTPol (AdvACT) experiment is currently underway and will consist of four Transition Edge Sensor (TES) bolometer arrays, with three operating together, totaling ~5800 detectors on the sky. Building on experience gained with the ACTPol detector arrays, AdvACT will utilize various new technologies, including 150mm detector wafers equipped with multichroic pixels, allowing for a more densely packed focal plane. Each set of detectors includes a feedhorn array of stacked silicon wafers which form a spline profile leading to each pixel. This is then followed by a waveguide interface plate, detector wafer, back short cavity plate, and backshort cap. Each array is housed in a custom designed structure manufactured from high purity copper and then gold plated. In addition to the detector array assembly, the array package also encloses cryogenic readout electronics. We present the full mechanical design of the AdvACT high frequency (HF) detector array package along with a detailed look at t...

  9. Advanced Virgo

    CERN Multimedia

    Virgo, a first-generation interferometric gravitational wave (GW) detector, located in the European Gravitational Observatory, EGO, Cascina (Pisa-Italy) and constructed by the collaboration of French and Italian institutes (CNRS and INFN) has successfully completed its long-duration data taking runs. It is now undergoing a fundamental upgrade that exploits available cutting edges technology to open an exciting new window on the universe, with the first detection of a gravitational wave signal. Advanced Virgo (AdV) is the project to upgrade the Virgo detector to a second-generation instrument. AdV will be able to scan a volume of the Universe 1000 times larger than initial Virgo. AdV will be hosted in the same infrastructures as Virgo. The Advanced VIRGO project is funded and at present carried on by a larger collaboration of institutes belonging to CNRS- France , RMKI - Hungary, INFN- Italy, Nikhef - The Netherlands Polish Academy of Science - Poland.

  10. Random sampling of the Central European bat fauna reveals the existence of numerous hitherto unknown adenoviruses.

    Science.gov (United States)

    Vidovszky, Márton; Kohl, Claudia; Boldogh, Sándor; Görföl, Tamás; Wibbelt, Gudrun; Kurth, Andreas; Harrach, Balázs

    2015-12-01

    From over 1250 extant species of the order Chiroptera, 25 and 28 are known to occur in Germany and Hungary, respectively. Close to 350 samples originating from 28 bat species (17 from Germany, 27 from Hungary) were screened for the presence of adenoviruses (AdVs) using a nested PCR that targets the DNA polymerase gene of AdVs. An additional PCR was designed and applied to amplify a fragment from the gene encoding the IVa2 protein of mastadenoviruses. All German samples originated from organs of bats found moribund or dead. The Hungarian samples were excrements collected from colonies of known bat species, throat or rectal swab samples, taken from live individuals that had been captured for faunistic surveys and migration studies, as well as internal organs of dead specimens. Overall, 51 samples (14.73%) were found positive. We detected 28 seemingly novel and six previously described bat AdVs by sequencing the PCR products. The positivity rate was the highest among the guano samples of bat colonies. In phylogeny reconstructions, the AdVs detected in bats clustered roughly, but not perfectly, according to the hosts' families (Vespertilionidae, Rhinolophidae, Hipposideridae, Phyllostomidae and Pteropodidae). In a few cases, identical sequences were derived from animals of closely related species. On the other hand, some bat species proved to harbour more than one type of AdV. The high prevalence of infection and the large number of chiropteran species worldwide make us hypothesise that hundreds of different yet unknown AdV types might circulate in bats.

  11. The Role of Major Gas-rich Mergers on the Evolution of Galaxies from the Blue Cloud to the Red Sequence

    Science.gov (United States)

    Guo, Rui; Hao, Cai-Na; Xia, X. Y.; Mao, Shude; Shi, Yong

    2016-07-01

    With the aim of exploring the fast evolutionary path from the blue cloud of star-forming galaxies to the red sequence of quiescent galaxies in the local universe, we select a local advanced merging infrared luminous and ultraluminous galaxy (adv-merger (U)LIRGs) sample and perform careful dust extinction corrections to investigate their positions in the star formation rate-M *, u - r, and NUV - r color-mass diagrams. The sample consists of 89 (U)LIRGs at the late merger stage, obtained from cross-correlating the Infrared Astronomical Satellite Point Source Catalog Redshift Survey and 1 Jy ULIRGs samples with the Sloan Digital Sky Survey DR7 database. Our results show that 74 % +/- 5 % of adv-merger (U)LIRGs are localized above the 1σ line of the local star-forming galaxy main sequence. We also find that all adv-merger (U)LIRGs are more massive than and as blue as the blue cloud galaxies after corrections for Galactic and internal dust extinctions, with 95 % +/- 2 % and 81 % +/- 4 % of them outside the blue cloud on the u - r and NUV - r color-mass diagrams, respectively. These results, combined with the short timescale for exhausting the molecular gas reservoir in adv-merger (U)LIRGs (3× {10}7 to 3× {10}8 years), imply that the adv-merger (U)LIRGs are likely at the starting point of the fast evolutionary track previously proposed by several groups. While the number density of adv-merger (U)LIRGs is only ˜ 0.1 % of the blue cloud star-forming galaxies in the local universe, this evolutionary track may play a more important role at high redshift.

  12. Diffusion tensor imaging of the brain in patients with Alzheimer's disease and cerebrovascular lesions

    Institute of Scientific and Technical Information of China (English)

    CHEN Shao-qiong; KANG Zhuang; HU Xi-quan; HU Bing; ZOU Yan

    2007-01-01

    Background: Recent autopsy study showed a high incidence ofcerebrovascular lesions in Alzheimer's disease (AD).To assess the impact of cerebrovascular pathology in AD, we used diffusion tensor imaging (DTI) to study AD patients with and without cerebrovascular lesions. Materials and Methods: Conventional and DTI scans were obtained from 10 patients with probable AD, 10 AD/V patients (probable AD with cerebrovascular lesions) and ten normal controls. Mean diffusivity (D) and fractional anisotropy (FA) values of some structures involved with AD pathology were measured. Results: D value was higher in AD patients than in controls in hippocampus and the cingulate gyrus. In AD/V patients, increased D value was found in the same structures and also in the thalamus and basal ganglia compared to controls. There was a significant difference of D value between AD and AD/V patients. FA value reduced in the white matter of left inferior temporal gyrus and in the bilateral middle cingulate gyrus in patients with AD/V compared with controls. The MMSE (mini-mental state examination) score significantly correlated with FA value in the right hippocampus (r=0.639, P<0.019), in the right anterior cingulate gyrus (r=0.587, P<0.035) and in left parahippocampal gyrus (r=0.559, P<0.047). Conclusion: Cerebrovascular pathology had stronger impact on the D value than the AD pathology alone did. Elevated D value in thalamic and basal ganglia may contribute to cognitive decline in AD/V patients.Reduced FA values in AD/V patients may indicate that cerebrovascular pathology induced more severe white matter damage than the AD pathology alone did.

  13. Suppressing tumor growth of nasopharyngeal carcinoma by hTERTC27 polypeptide delivered through adeno-associated virus plus adenovirus vector cocktail

    Institute of Scientific and Technical Information of China (English)

    Xiong Liu; Xiang-Ping Li; Ying Peng; Samuel S.Ng; Hong Yao; Zi-Feng Wang; Xiao-Mei Wang; Hsiang-Fu Kung; Marie C.M.Lin

    2012-01-01

    Nasopharyngeal carcinoma(NPC) is a metastatic carcinoma that is highly prevalent in Southeast Asia.Our laboratory has previously demonstrated that the C-terminal 27-kDa polypeptide of human telomerase reverse transcriptase (hTERTC27) inhibits the growth and tumorigenicity of human glioblastoma and melanoma cells.In this study,we investigated the antitumor effect of hTERTC27 in human C666-1 NPC cells xenografted in a nude mouse model.A cocktail of vectors comprising recombinant adeno-associated virus (rAAV) and recombinant adenovirus (rAdv) that each carry hTERTC27 (rAAV-hTERTC27 and rAdv-hTERTC27; the cocktail was abbreviated to rAAV/rAdv-hTERTC27) was more effective than either rAAV-hTERTC27 or rAdv-hTERTC27 alone in inhibiting the growth of C666-1 NPC xenografts.Furthermore,we established three tumors on each mouse and injected rAAV/rAdv-hTERTC27 into one tumor per mouse.Although hTERTC27 expression could only be detected in the injected tumors,reduced tumor growth was observed in the injected tumor as well as the uninjected tumors,demonstrating that the vector cocktail could provoke an antitumor effect on distant,metastasized tumors.Further studies showed the observed antitumor effects included inducing necrosis and apoptosis and reducing microvessel density.Together,our data suggest that the rAAV/rAdv-hTERTC27 cocktail can potently inhibit NPC tumor growth in both local and metastasized tumors and should be further developed as a novel gene therapy strategy for NPC.

  14. High-level recombinant protein production in CHO cells using an adenoviral vector and the cumate gene-switch.

    Science.gov (United States)

    Gaillet, Bruno; Gilbert, Rénald; Amziani, Rachid; Guilbault, Claire; Gadoury, Christine; Caron, Antoine W; Mullick, Alaka; Garnier, Alain; Massie, Bernard

    2007-01-01

    To facilitate and accelerate the production of eukaryotic proteins with correct post-translational modifications, we have developed a protein production system based on the transduction of Chinese hamster ovary (CHO) cells using adenovirus vectors (AdVs). We have engineered a CHO cell line (CHO-cTA) that stably expresses the transactivator (cTA) of our newly developed cumate gene-switch transcription system. This cell line is adapted to suspension culture and can grow in serum-free and protein-free medium. To increase the transduction level of AdVs, we have also generated a cell line (CHO-cTA-CAR) that expresses additional amounts of the coxackievirus and adenovirus receptor (CAR) on its surface. Recombinant protein production was tested using an AdV carrying the secreted alkaline phosphatase (SEAP) under the control of the CR5 promoter, which is strongly and specifically activated by binding to cTA. The SEAP expression was linked to the expression of the green fluorescent protein (GFP) through an internal ribosome entry site (IRES) to facilitate titration of the AdV. We monitored SEAP expression on a daily basis for 9 days after transduction of CHO-cTA and CHO-cTA-CAR using different quantities of AdVs at 37 and 30 degrees C. Incubation at the latter temperature increased the production of SEAP at least 10-fold, and the presence of CAR increased the transduction level of the AdV. Maximum SEAP production (63 mg/L) was achieved at 6-7 days post-infection at 30 degrees C by transducing CHO-cTA-CAR with 500 infectious particles/cell. Because numerous AdVs can now be generated within a few weeks and large-scale production of AdVs is now a routine procedure, this system could be used to produce rapidly milligram quantities of a battery of recombinant proteins as well as for large-scale protein production.

  15. The NOW regional coupled model: Application to the tropical Indian Ocean climate and tropical cyclone activity

    Digital Repository Service at National Institute of Oceanography (India)

    Samson, G.; Masson, S.; Lengaigne, M.; Keerthi, M.G.; Vialard, J.; Pous, S.; Madec, G.; Jourdain, N.C.; Jullien, S.; Menkes, C.; Marchesiello, P.

    over the western equatorial IO (Figure 8c). The largest model bias is associated with rainfall, with a large overestimation of the precipitation increase over the western IO in both simulations (Figures 8e and 8 f). Figure 7b displays the observed... stream_size 91005 stream_content_type text/plain stream_name J_Adv_Model_Earth_Syst_6_700.pdf.txt stream_source_info J_Adv_Model_Earth_Syst_6_700.pdf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8...

  16. In-situ and Post-cure Surface Modification of PDMS Elastomers for Low Surface Energy Applications

    Science.gov (United States)

    2014-12-01

    Iodide Water Superomniphobic fabrics via dip-coating Transparent Omniphobicity Oil/ water emulsion gravity seperation Golovin et al., Ang. Chem., 2013...Hydrosilylation n ≈ 24 1, 5, 10, 20, 44 wt% Vinyl: silane , 1:32, 1:8, 1:4, 1:2, 1:1 Distribution A: Approved for Public Release; Distribution Unlimited 7...fluorodecyl8T8 POSS: Water adv/ rec = 124°/116° Hexadecaneadv/ rec = 80°/61° Distribution A: Approved for Public Release; Distribution Unlimited 12 F-POSS

  17. Concurrent anti-vascular therapy and chemotherapy in solid tumors using drug-loaded acoustic nanodroplet vaporization.

    Science.gov (United States)

    Ho, Yi-Ju; Yeh, Chih-Kuang

    2017-02-01

    Drug-loaded nanodroplets (NDs) can be converted into gas bubbles through ultrasound (US) stimulation, termed acoustic droplet vaporization (ADV), which provides a potential strategy to simultaneously induce vascular disruption and release drugs for combined physical anti-vascular therapy and chemotherapy. Doxorubicin-loaded NDs (DOX-NDs) with a mean size of 214nm containing 2.48mg DOX/mL were used in this study. High-speed images displayed bubble formation and cell debris, demonstrating the reduction in cell viability after ADV. Intravital imaging provided direct visualization of disrupted tumor vessels (vessel size chemotherapy with DOX-NDs vaporization promotes uniform treatment to improve therapeutic efficacy.

  18. Novel adenovirus detected in kowari (Dasyuroides byrnei) with pneumonia.

    Science.gov (United States)

    Gál, János; Mándoki, Míra; Sós, Endre; Kertész, Péter; Koroknai, Viktória; Bányai, Krisztián; Farkas, Szilvia L

    2017-02-15

    A male kowari (Dasyuroides byrnei) originating from a zoo facility was delivered for post mortem evaluation in Hungary. Acute lobar pneumonia with histopathologic changes resembling an adenovirus (AdV) infection was detected by light microscopic examination. The presence of an AdV was confirmed by obtaining partial sequence data from the adenoviral DNA-dependent DNA-polymerase. Although the exact taxonomic position of this novel marsupial origin virus could not be determined, pairwise identity analyses and phylogenetic calculations revealed that it is distantly related to other members in the family Adenoviridae.

  19. Three-Dimensional Structure of Canine Adenovirus Serotype 2 Capsid▿

    OpenAIRE

    Schoehn, Guy; El Bakkouri, Majida; Fabry, Céline M. S.; Billet, Oliver; Leandro F. Estrozi; Le, Van Long; Curiel, David T.; Kajava, Andrey V; Ruigrok, Rob W. H.; Eric J Kremer

    2008-01-01

    There are more than 100 known adenovirus (AdV) serotypes, including 50 human serotypes. Because AdV-induced disease is relatively species specific, vectors derived from nonhuman serotypes may have wider clinical potential based, in part, on the lack of ubiquitous memory immunity. Whereas a few of the human serotype capsids have been studied at the structural level, none of the nonhuman serotypes has been analyzed. The basis laid by the analysis of human AdV (hAdV) has allowed us to determine ...

  20. Six cases of hypophosphataemic osteomalacia induced by adefovir dipivoxil%阿德福韦酯致低磷性骨软化症六例分析

    Institute of Scientific and Technical Information of China (English)

    张楠; 邵明玮; 黄爱; 栗夏莲; 秦贵军; 汪丽娟

    2013-01-01

    分析近14个月确诊的6例阿德福韦酯(ADV)相关性肾病患者的临床资料及诊治经过.结果显示,服用ADV 10~20 mg/d,2~3年后出现全身多处骨关节疼痛.均有低磷、低尿酸血症,成骨指标明显升高,1例血肌酐升高,5例有低血钾、肾性糖尿,4例有蛋白尿,影像学检查提示骨质疏松、骨软化、假性骨折.确诊后停用ADV,经补磷及活性D3后,3~6周疼痛缓解,1~2.5个月血尿酸正常,1~2个月肾性糖尿及蛋白尿消失.提示ADV应用超过2年,应注意其引起的肾损害,定期监测肾功能、电解质、尿常规可早期发现肾损害.血尿酸降低是一个较好的诊疗观察指标.%[Summary] An analysis of clinical data was performed in 6 patients diagnosed as adefovir dipivoxil (ADV)-induced nephropathy in recent 14 months.The results showed that all of six patients suffered from pain over multiple joints after taking ADV 10-20 mg/d for 2-3 years,along with hypophosphatemia,hypouricemia,and raised osteogenesis index.One case had increased serum creatinine,5 cases had hypokalemia,renal glycosuria,and4 cases had albuminuria.Imageological examination showed osteoporosis,osteomalacia,and pseudo fracture.After discontinuance of ADV treatment,joint pain was obviously relieved within 3-6 weeks,blood uric acid level returned to normal within 1-2.5 months,and renal glycosuria and albuminuria disappeared by 1-2 months.The results suggest that after taking ADV for more than two years,attention should be paid to the nephropathy induced by ADV and regular monitoring of renal function,blood electrolyte,and urine should be mandatory.Hypouricemia is a reliable index of diagnosis and treatment in this event.

  1. Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy

    OpenAIRE

    Zhang, Xing-Guo; Miao, Jing; Li, Min-wei; Jiang,Sai-Ping; Hu, Fu-Qiang; Du, Yong-Zhong

    2008-01-01

    Herein, solid lipid nanoparticles (SLN) were proposed as a new drug delivery system for adefovir dipivoxil (ADV). The octadecylamine-fluorescein isothiocynate (ODA-FITC) was synthesized and used as a fluorescence maker to be incorporated into SLN to investigate the time-dependent cellular uptake of SLN by HepG2.2.15. The SLN of monostearin with ODA-FITC or ADV were prepared by solvent diffusion method in an aqueous system. About 15 wt% drug entrapment efficiency (EE) and 3 wt% drug loading (D...

  2. Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To establish the more feasible and sensitive assessment approach to the detection of adefovir (ADV) resistance-associated hepatitis B virus (HBV) quasispecies.METHODS: Based on the characteristics of rtA181V/T and rtN236T mutations, a new approach based on real-time fluorescent quantitative polymerase chain reaction (RT-PCR) was established for the detection of ADV-resistant HBV quasispecies, total HBV DNA, rtA181 and rtN236 mutations in blood samples from 32 chronic hepatitis B (CHB) patients with unsa...

  3. Assessing Photocatalytic Oxidation Using Modified TiO 2 Nanomaterials for Virus Inactivation in Drinking Water: Mechanisms and Application

    Science.gov (United States)

    Liga, Michael Vincent

    Photocatalytic oxidation is an alternative water treatment method under consideration for disinfecting water. Chlorine disinfection can form harmful byproducts, and some viruses (e.g. adenoviruses) are resistant to other alternative disinfection methods. Photocatalytic oxidation using nano-sized photocatalytic particles (e.g. TiO2, fullerene) holds promise; however, it is limited by its low efficiency and long required treatment times. This research focuses on improving virus inactivation by photocatalytic oxidation by modifying catalysts for improved activity, by analyzing virus inactivation kinetics, and by elucidating the inactivation mechanisms of adenovirus serotype 2 (AdV2) and bacteriophage MS2. Modifying TiO2 with silver (nAg/TiO2) or silica (SiO2-TiO2) improves the inactivation kinetics of bacteriophage MS2 by a factor of 3-10. nAg/ TiO2 increases hydroxyl radical (HO·) production while SiO2 increases the adsorption of MS2 to TiO 2. These results suggest that modifying the photocatalyst surface to increase contaminant adsorption is an important improvement strategy along with increasing HO· production. The inactivation kinetics of AdV2 by P25 TiO2 is much slower than the MS2 inactivation kinetics and displays a strong shoulder, which is not present in the MS2 kinetics. nAg/TiO2 initially improves the inactivation rate of AdV2. SiO2-TiO2 reduces the AdV2 inactivation kinetics since adsorption is not significantly enhanced, as it is with MS2. Amino-C60 is highly effective for AdV2 inactivation under visible light irradiation, making it a good material for use in solar disinfection systems. The efficacy of amino-fullerene also demonstrates that singlet oxygen is effective for AdV2 inactivation. When exposed to irradiated TiO2, AdV2 hexon proteins are heavily damaged resulting in the release of DNA. DNA damage is also present but may occur after capsids break. With MS2, the host interaction protein is rapidly damaged, but not the coat protein. The kinetics

  4. Quantum stopping times stochastic integral in the interacting Fock space

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Yuanbao, E-mail: kangyuanb@163.com [College of Mathematics Science, Chong Qing Normal University, Chongqing 400047 (China)

    2015-08-15

    Following the ideas of Hudson [J. Funct. Anal. 34(2), 266-281 (1979)] and Parthasarathy and Sinha [Probab. Theory Relat. Fields 73, 317-349 (1987)], we define a quantum stopping time (QST, for short) τ in the interacting Fock space (IFS, for short), Γ, over L{sup 2}(ℝ{sup +}), which is actually a spectral measure in [0, ∞] such that τ([0, t]) is an adapted process. Motivated by Parthasarathy and Sinha [Probab. Theory Relat. Fields 73, 317-349 (1987)] and Applebaum [J. Funct. Anal. 65, 273-291 (1986)], we also develop a corresponding quantum stopping time stochastic integral (QSTSI, for abbreviations) on the IFS over a subspace of L{sup 2}(ℝ{sup +}) equipped with a filtration. As an application, such integral provides a useful tool for proving that Γ admits a strong factorisation, i.e., Γ = Γ{sub τ]} ⊗ Γ{sub [τ}, where Γ{sub τ]} and Γ{sub [τ} stand for the part “before τ” and the part “after τ,” respectively. Additionally, this integral also gives rise to a natural composition operation among QST to make the space of all QSTs a semigroup.

  5. Disease: H00396 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available am Pract 55:500-2 (2006) PMID:21120728 MacDonald N, Hatchette T, Elkout L, Sarwal S Mumps is back: why is mumps eradication not worki...ng? Adv Exp Med Biol 697:197-220 (2011) PMID:19815120 (d

  6. Chinese Public’s Willingness to Pay for CO2 Emissions Reductions: A Case Study from Four Provinces/Cities

    Directory of Open Access Journals (Sweden)

    Duan Hong-Xia

    2014-01-01

    Citation: Duan, H.-X., Lü, Y.-L., Li, Y., 2014. Chinese public’s willingness to pay for CO2 emissions reductions: A case study from four provinces/cities. Adv. Clim. Change Res. 5(2, doi: 10.3724/SP.J.1248.2014.100.

  7. Comparison of different DNA isolation methods and use of dodecyle trimethyl ammonium bromide (DTAB for the isolation of DNA from meat products

    Directory of Open Access Journals (Sweden)

    Yusuf OZsENSOY

    2016-12-01

    Conclusion: DNA isolation kit, another best method, is recommended due to quality and quantity of DNA for researchers who do not want that phenol/chloroform method have toxic substances. This study is also the first study in which DTAB method is used for DNA extraction from meat products. [J Adv Vet Anim Res 2016; 3(4.000: 368-374

  8. Transportation scenario of Black Bengal goats in Gabtoli and Sirajganj markets of Bangladesh

    Directory of Open Access Journals (Sweden)

    Mohammed Nazmus sakib

    2016-03-01

    Conclusion: From this study it is concluded that Black Bengal goats became physically unfit during long time transportation although majority of the farmers took proper management practices. Therefore, changes in behavioral responses might be alleviated through creating awareness to animal raiser as well transporter. [J Adv Vet Anim Res 2016; 3(1.000: 38-44

  9. Quality assessment of imported powder milk at Mansoura city, Egypt

    Directory of Open Access Journals (Sweden)

    Adel Abdelkhalek

    2016-03-01

    Conclusion: Based on the Egyptian Standards, the samples were satisfactory in terms of the association of Salmonella spp., E. coli, and fungi. Contamination with Staph. aureus warrans the public health. Thus, appropriate care and preventive measures are suggested. [J Adv Vet Anim Res 2016; 3(1.000: 75-78

  10. Two parvoviruses that cause different diseases in mink have different transcription patterns: Transcription analysis of mink enteritis virus and Aleutian mink disease parvovirus the same cell line

    DEFF Research Database (Denmark)

    Storgaard, T.; Oleksiewicz, M.; Bloom, M.E.;

    1997-01-01

    The two parvoviruses of mink cause very different diseases, Mink enteritis virus (MEV) is associated with rapid, high-level viral replication and acute disease, In contrast, infection with Aleutian mink disease parvovirus (ADV) is associated with persistent, low-level viral replication and chronic...

  11. Seroprevalence of Chlamydia abortus in camel in the western region of Libya

    Directory of Open Access Journals (Sweden)

    Rabia Elzlitne

    2016-06-01

    Conclusion: The present findings signify the C. abortus as a potential agent to cause abortion in Libyan camel (C. dromedarius. Besides, the persons who handle camels in Libya are at risk of infecting with C. abortus. [J Adv Vet Anim Res 2016; 3(2.000: 178-183

  12. Measuring violations of General Relativity from single gravitational wave detection by non-spinning binary systems: higher-order asymptotic analysis

    CERN Document Server

    Tso, Rhondale

    2015-01-01

    A frequentist asymptotic expansion method for error estimation is employed for a network of gravitational wave detectors to assess the capability of gravitational wave observations, with Adv. LIGO and Adv. Virgo, to distinguish between the post-Einsteinian (ppE) description of coalescing binary systems and that of GR. When such errors are smaller than the parameter value, there is possibility to detect these violations from GR. A parameter space with inclusion of dominant dephasing ppE parameters is used for a study of first- and second-order (co)variance expansions, focusing on the inspiral stage of a nonspinning binary system of zero eccentricity detectible through Adv. LIGO and Adv. Virgo. Our procedure is more reliable than frequentist studies based only on Fisher information estimates and complements Bayesian studies. Second-order asymptotics indicate the possibility of constraining deviations from GR in low-SNR ($\\rho \\sim 15-17$) regimes. The errors on $\\beta$ also increase errors of other parameters s...

  13. A Molecular Analysis of the Induction of Class II Major Histocompatibility Antigen Expression on Murine Macrophages by Interferon-Gamma and Its Down-Regulation by Interferon-Alpha/Beta and Dexamethasone

    Science.gov (United States)

    1989-11-09

    to Drs. Kathleen Barr, Carl Dieffenbach, Marion Fultz, M. Michele Hogan, Paul Kinchington, John McGowan, Larry Smith and M. Kim Warren for their...endotoxins and host immune responses. Adv. Immunol. 28:293. Morrissey, P. J., L. Bressler, L. S. Park, A. Alpert , and S. Gillis. 1987. Granulocyte

  14. Convective Heat Transfer in Internal Gas Flows with Temperature-Dependent Properties.

    Science.gov (United States)

    1982-06-30

    effects of variable properties have been provided by Petukhov [1970],specifically for turbulent flow in circular tubes.and by Leontiev o for the...243-249. Leontiev , A. I., 1966. Heat and mass transfer in turbulent boundary layers, Adv. Heat Transfer, 3, pp. 33-100. Leung, E. Y., V. M. Kays and W

  15. Onderzoek location based marketing: Mobile = location = effect

    NARCIS (Netherlands)

    Gisbergen, M.S. van; Huhn, A.E.; Khan, V.J.; Ketelaar, P.E.

    2011-01-01

    Onderzoekers van de NHTV (Internationaa Hoger Onderwijs Breda, Radboud Universiteit, DVJ Insights en Popai Benelux lieten consumenten in een virtuele supermarkt advertenties via de smartphone ontvangen wanneer men langs het geadverteerde product liep. De uitkomsten laten zien dat 'location based adv

  16. Telewarfare and Military Medicine: White Paper/State of the Art Report On AFMS Support to the Emerging Paradigm of Employed-in-Place Operations

    Science.gov (United States)

    2011-09-30

    syndrome’? Population-based healthcare for chronic idiopathic pain and fatigue after war; Adv Psychosom Med. 2004; 25:102-22. Review. 30) Ferguson CJ...White RF, Wolfe J, Borgos MS, Davis JD, Pepper L, Clapp R, Sutker PB, Vasterling JJ, Ozonoff D.; Health status of Persian Gulf War veterans: self

  17. Arctic Basemaps In Google Maps

    DEFF Research Database (Denmark)

    Muggah, J.; Mioc, Darka

    2010-01-01

    The Ocean Mapping Group has been collecting data in the Arctic since 2003 and there are approximately 2,000 basemaps. In the current online storage format used by the OMG, it is difficult to view the data and users cannot easily pan and zoom. The purpose of this research is to investigate the adv...

  18. Aujeszky's disease virus production in disposable bioreactor

    Indian Academy of Sciences (India)

    I Slivac; V Gaurina Srček; K Radošević; I Kmetič; Z Kniewald

    2006-09-01

    A novel, disposable-bag bioreactor system that uses wave action for mixing and transferring oxygen was evaluated for BHK 21 C13 cell line growth and Aujeszky’s disease virus (ADV) production. Growth kinetics of BHK 21 C13 cells in the wave bioreactor during 3-day period were determined. At the end of the 3-day culture period and cell density of 1.82 × 106 cells ml–1, the reactor was inoculated with 9 ml of gE- Bartha K-61 strain ADV suspension (105.9 TCID50) with multiplicity of infection (MOI) of 0.01. After a 144 h incubation period, 400 ml of ADV harvest was obtained with titre of 107.0 TCID50 ml–1, which corresponds to 40,000 doses of vaccine against AD. In conclusion, the results obtained with the wave bioreactor using BHK 21 C13 cells showed that this system can be considered as suitable for ADV or BHK 21 C13 cell biomass production.

  19. Occurrence of adenovirus infection and clinical impact in paediatric stem cell transplant recipients

    Directory of Open Access Journals (Sweden)

    Gabriele Bianco

    2016-10-01

    Full Text Available In this study, the occurrence and clinical impact of adenovirus (AdV infection was investigated in paediatric hematopoietic stem cell transplantation (HSCT recipients. A number of 603 specimens (including whole blood, respiratory and other samples from 181 patients were tested by real-time polymerase chain reaction; clinical outcome was investigated. Overall, 118/603 (19.6% specimens from 21/181 (11.6% patients resulted positive to AdV (including 17.3, 29.9, 17.6, and 15.8% of total number of whole blood, respiratory, urine and other specimens, respectively. On whole blood specimens, viral loads ranged from <600 (limit of detection to >5×106 copies/mL, with a median value 2×104. Multiple specimens were positive in patients in which viral load on whole blood was high. Adenoviral positivity on whole blood was associated to poor prognosis, as death occurred in three of ten (30% patients with persistent positivity on whole blood specimens, also despite the administration of an antiviral agent (cidofovir. Adenovirus infection can account for systemic and/or organ-specific signs/symptoms in approximately 10% of paediatric HSCT recipients. At moment, there is no indication for routine monitor of AdV in these patients, although AdV aetiology of infectious transplant complications should be taken in account.

  20. Severe Necrotizing Adenovirus Tubulointerstitial Nephritis in a Kidney Transplant Recipient

    Directory of Open Access Journals (Sweden)

    Ravi Parasuraman

    2013-01-01

    Full Text Available Adenoviruses (AdV are emerging pathogens with a prevalence of 11% viruria and 6.5% viremia in kidney transplant recipients. Although AdV infection is common, interstitial nephritis (ADVIN is rare with only 13 biopsy proven cases reported in the literature. We report a case of severe ADVIN with characteristic histological features that includes severe necrotizing granulomatous lesion with widespread tubular basement membrane rupture and hyperchromatic smudgy intranuclear inclusions in the tubular epithelial cells. The patient was asymptomatic at presentation, and the high AdV viral load (quantitative PCR>2,000,000 copies/mL in the urine and 646,642 copies/mL in the serum confirmed the diagnosis. The patient showed excellent response to a combination of immunosuppression reduction, intravenous cidofovir, and immunoglobulin therapy resulting in complete resolution of infection and recovery of allograft function. Awareness of characteristic biopsy findings may help to clinch the diagnosis early which is essential since the disseminated infection is associated with high mortality of 18% in kidney transplant recipients. Cidofovir is considered the agent of choice for AdV infection in immunocompromised despite lack of randomized trials, and the addition of intravenous immunoglobulin may aid in resolution of infection while help prevention of rejection.

  1. Colloidal Stability of Gold Nanoparticles Coated with Multithiol-Poly(ethylene glycol) Ligands: Importance of Structural Constraints of the Sulfur Anchoring Groups

    Science.gov (United States)

    2013-08-13

    dimercaptooctanoic acid) has a chiral center at C6 position. Those two enantiomers have slightly different low energy conformer for both sulfur...PEGylated Nanoparticles for Biological and Pharmaceutical Applications. Adv Drug Deliver Rev 2012, 64, 246-255. 14. Oh, E.; Fatemi, F. K.; Currie

  2. Why Advisory Services in Small Firm Ownership Transfers Fail : Three Policy Recommendations to Improve Support

    NARCIS (Netherlands)

    Teeffelen, Lex van

    2011-01-01

    Many policy makers are unaware of the pitfalls in ownership transfers in SMEs and the inadequate advisory services. This paper presents the economic importance of business transfers, the research evidence to date on the main issues in ownership changes and discusses potential policies to reduce (adv

  3. The Passive, Ground-Based, Electro-Optical Detection of Synchronous Satellites

    Science.gov (United States)

    1978-06-19

    Lincoln Laboratory, M.I.T. (16 August 1974), DDC AD-785137/1. 47 12. V. J. Santilli and G. B. Conger III, Adv. Electron. Electron Phys. 33A, 219...Air Force Systems Command, USAF Andrews AFB Washington, DC 20331 12. REPORT DATE 19 June 1978 13. NUMBER OF PAGES 54 14. MONITORING

  4. Acquired natural enemies of the weed biological control agent Oxyops vitiosa (Coleoptera: Curculionidae)

    Science.gov (United States)

    The Australian curculionid Oxyops vitiosa Pascoe was introduced into Florida during 1997 as a biological control agent of the invasive tree Melaleuca quinquenervia (Cav.) S.T. Blake. Populations of the weevil increased rapidly and became widely distributed throughout much of the invasive tree’s adve...

  5. Functional consequences of iron deficiency in Chinese female workers.

    NARCIS (Netherlands)

    Li, R.

    1993-01-01

    Women of the reproductive age in China play a very important role in the labour force. Information on anaemia prevalence in this group is hardly available, notwithstanding the fact that iron deficiency anaemia is considered to be a major public health problem in China. Iron deficiency may cause adve

  6. The Kidney and Acid-Base Regulation

    Science.gov (United States)

    Koeppen, Bruce M.

    2009-01-01

    Since the topic of the role of the kidneys in the regulation of acid base balance was last reviewed from a teaching perspective (Koeppen BM. Renal regulation of acid-base balance. Adv Physiol Educ 20: 132-141, 1998), our understanding of the specific membrane transporters involved in H+, HCO , and NH transport, and especially how these…

  7. New Applications of Ionization and Fluorescence Techniques for Detecting and Characterization of Open-Shell Organometallics in the Gas Phase

    Science.gov (United States)

    1992-06-01

    Poliakoff , M.; Weitz, E. Adv~ Organomet Chem. 19 86,25,277. 21. (a) Graham, M. A.; Perutz, R. N.; Poliakoff , M.; Turner, J. J. J. Organomet Chem. 1972,34...Turner, J. J. J. Am. Chem. Soc. 1975,97,4800. (e) Burdett, J. K.; Graham, M. A.; Perutz, R. N.; Poliakoff , M.; Turner, J. J.; Turner, R. F. J. Am. Chem

  8. New Applications of Ionization and Fluorescence Techniques for Detection and Characterization of Open-Shell Organometallics in the Gas Phase

    Science.gov (United States)

    1992-06-01

    112, 3668. 20. Poliakoff , M.; Weitz, E. Adv Organomet. Chem. 19 86, 25,277. 21. (a) Graham, M. A.; Perutz, R. N.; Poliakoff , M.; Turner, J. J. J...Perutz, R. N.; Turner, J. J. J. Am. Chem. Soc. 1975,97,4800. (e) Burdett, J. K.; Graham, M. A.; Perutz, R. N.; Poliakoff , M.; Turner, J. J.; Turner

  9. Random Sampling of Squamate Reptiles in Spanish Natural Reserves Reveals the Presence of Novel Adenoviruses in Lacertids (Family Lacertidae) and Worm Lizards (Amphisbaenia)

    Science.gov (United States)

    Szirovicza, Leonóra; López, Pilar; Kopena, Renáta; Benkő, Mária; Martín, José; Pénzes, Judit J.

    2016-01-01

    Here, we report the results of a large-scale PCR survey on the prevalence and diversity of adenoviruses (AdVs) in samples collected randomly from free-living reptiles. On the territories of the Guadarrama Mountains National Park in Central Spain and of the Chafarinas Islands in North Africa, cloacal swabs were taken from 318 specimens of eight native species representing five squamate reptilian families. The healthy-looking animals had been captured temporarily for physiological and ethological examinations, after which they were released. We found 22 AdV-positive samples in representatives of three species, all from Central Spain. Sequence analysis of the PCR products revealed the existence of three hitherto unknown AdVs in 11 Carpetane rock lizards (Iberolacerta cyreni), nine Iberian worm lizards (Blanus cinereus), and two Iberian green lizards (Lacerta schreiberi), respectively. Phylogeny inference showed every novel putative virus to be a member of the genus Atadenovirus. This is the very first description of the occurrence of AdVs in amphisbaenian and lacertid hosts. Unlike all squamate atadenoviruses examined previously, two of the novel putative AdVs had A+T rich DNA, a feature generally deemed to mirror previous host switch events. Our results shed new light on the diversity and evolution of atadenoviruses. PMID:27399970

  10. Sustained Release Oral Nanoformulated Green Tea for Prostate Cancer Prevention

    Science.gov (United States)

    2013-05-01

    delivery to treat age-related macular degeneration . Mol Vis, 18, 2300-8. 23. Borchard, G. (2001) Chitosans for gene delivery. Adv Drug Deliv Rev, 52...imadzu Pro s, a SIL-20 fireTM C18 mobile phas ml/min and API 4000 ada) equipp spectromet ive analyses tive analyse ical chroma (i) shows e chromato

  11. 77 FR 28909 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

    Science.gov (United States)

    2012-05-16

    ... in Endnote 3. Endnote 3 provides that ``ADV'' means, with respect to an ETP Holder, the number of... for the calendar month (or partial month, as applicable) in which the executions occurred. Endnote 3... described above. Explanatory Endnote 8 of the Fee Schedule describes the market data revenue rebate...

  12. 77 FR 67419 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing and Immediate Effectiveness of a...

    Science.gov (United States)

    2012-11-09

    ... and the volume threshold of 3,500,000 contracts described in endnote 5 in the Fee Schedule (ii) the $100,000 fee cap described in endnote 6 of the Fee Schedule, (iii) the 75% volume threshold related to... Electronic ADV Tiers, and (v) the 120,000 and 200,000 volume thresholds described in endnote 17 of the...

  13. 77 FR 56886 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

    Science.gov (United States)

    2012-09-14

    ... Endnote 4. The Exchange proposes to define the ADV as the average number of shares the ETP Holder has..., 2012.\\7\\ \\6\\ See Endnote 3. \\7\\ See Endnote 3. ETP Holders may elect to adopt the ``Variable Fee... participants will not be subject to this fee schedule. \\8\\ See Endnote 9. As stated above, an ETP Holder...

  14. 77 FR 14450 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

    Science.gov (United States)

    2012-03-09

    ... liquidity based upon an ETP Holder's Liquidity Adding ADV (as such term is defined in Endnote 3 of the Fee... whether the security is Tape A, B or C. Corresponding edits are made to Endnote 3 to reflect the... (as defined in Endnote 4 of the Fee Schedule) that add liquidity in AutoEx, the Exchange...

  15. 76 FR 20412 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

    Science.gov (United States)

    2011-04-12

    ... daily volume (as such term is defined in Endnote 3 of the Fee Schedule, ``Liquidity Adding ADV'') is less than 20 basis points of Total Consolidated Average Daily Volume (as defined in Endnote 13 of the... with Endnote 8), and NSX Rule 16.4 would be deleted in its entirety. \\5\\ NSX Rule 16.4(b). To...

  16. Mineralogy of Antarctica Dry Valley Soils: Implications for Pedogenic Processes on Mars

    Science.gov (United States)

    Quinn, J. E.; Ming, D. W.; Morris, R. V.; Douglas, S.; Kounaves, S. P.; McKay, C. P.; Tamppari, L, K.; Smith, P. H.; Zent, A. P.; Archer, P. D., Jr.

    2010-01-01

    The Antarctic Dry Valleys (ADVs) located in the Transantarctic Mountains are the coldest and driest locations on Earth. The mean annual air temperature is -20 C or less and the ADVs receive 100mm or less of precipitation annually in the form of snow. The cold and dry climate in the ADVs is one of the best terrestrial analogs for the climatic conditions on Mars [2]. The soils in the ADVs have been categorized into three soil moisture zones: subxerous, xerous and ultraxerous. The subxerous zone is a coastal region in which soils have ice-cemented permafrost relatively close to the surface. Moisture is available in relatively large amounts and soil temperatures are above freezing throughout the soil profile (above ice permafrost) in summer months. The xerous zone, the most widespread of the three zones, is an inland region with a climate midway between the subxerous and ultraxerous. The soils from this zone have dry permafrost at moderate depths (30-75cm) but have sufficient water in the upper soil horizons to allow leaching of soluble materials. The ultraxerous zone is a high elevation zone, where both temperature and precipitation amounts are very low resulting in dry permafrost throughout the soil profile. The three moisture regime regions are similar to the three microclimatic zones (coastal thaw, inland mixed, stable upland) defined by Marchant and Head.

  17. The Impact of Abstract versus Concrete Product Communications on Consumer Decision-making Processes

    NARCIS (Netherlands)

    M.N.G. van Ginkel-Bieshaar (Mirjam)

    2012-01-01

    textabstractWith the growth of online shopping, a new era of market communication is administered. Internet as a combined communication- and sales-channel has blurred the borders between persuasive communications to activate goals (i.e., abstract messages that are traditionally communicated via adve

  18. Vegetables Business Opportunities in Ghana: 2014

    NARCIS (Netherlands)

    Saavedra Gonzalez, Y.R.; Dijkxhoorn, Y.; Elings, A.; Glover-Tay, J.; Koomen, I.; Maden, van der E.C.L.J.; Nkansah, G.; Obeng, P.

    2014-01-01

    This report addresses the current performance, overall business climate of the vegetable sector and tries to come up with a number of business opportunities. These include business opportunities for high-quality exports, greenhouse technology, and healthy food for the domestic market. It equally adv

  19. Reassuring results on birth outcomes in children fathered by men treated with azathioprine/6-mercaptopurine within 3 months before conception

    DEFF Research Database (Denmark)

    Nørgård, B M; Magnussen, B; Larsen, M D;

    2017-01-01

    OBJECTIVE: Information on the safety of paternal use of azathioprine (AZA) and 6-mercaptopurine (6-MP) prior to conception is limited. Based on nationwide data from the Danish health registries, we examined the association between paternal use of AZA/6-MP within 3 months before conception and adv...

  20. Military Medical Revolution: Military Trauma System

    Science.gov (United States)

    2012-01-01

    for hypotensive patients with penetrating torso injuries. N Engl J Med. 1994;331:1105. 10. Arishita GI, Vayer JS, Bellamy RF. Cervical spine... orthosis change hearts and minds? J Surg Orthop Adv. 2011;20:8 18. 49. Patzkowski JC, Blanck RV, Owens JG, et al. Comparative effect of or- thosis