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Sample records for adult holding conditions

  1. Improving mating performance of mass-reared sterile Mediterranean fruit flies (Diptera: Tephritidae) through changes in adult holding conditions: demography and mating competitiveness

    International Nuclear Information System (INIS)

    Mass rearing conditions affect the mating behavior of Mediterranean fruit flies (medflies) Ceratitis capitata (Wiedemann). We evaluated the effect of slight changes in the adult holding conditions of adult flies maintained for egg production on their mating performance. Colonization was initiated from wild flies collected as larvae from infested coffee berries (Coffea arabica L.). When pupae were close to adult emergence, they were randomly divided into 3 groups and the emerging adults were reared under the following conditions: (1) Metapa System (MS, control), consisting of 70 x 45 x 15 cm aluminum frame, mesh covered cages, with a density of 2,200 flies per cage and a 1:1 initial sex ratio; (2) Insert System (IS), with the same type of cage, and the same fly density and sex ratio as in the MS treatment, but containing twelve Plexiglas pieces (23 x 8.5 cm) to provide additional horizontal surface areas inside the cage; and (3) Sex-ratio System (SS), same as IS, but in this case the initial male: female ratio was 4:1. Three d later, newly emerged females were introduced, so the ratio became 3:1 and on the 6th d another group of newly emerged females was added to provide a 2:1 final sex ratio, at which the final density reached 1,675 flies per cage. The eggs collected from each of the 3 treatments were reared independently following standard procedures and the adults were held under the same experimental conditions. This process was repeated for over 10 to 13 generations (1 year). The experiment was repeated 3 times in 3 consecutive years, starting each replicate with a new collection of wild flies. Life tables were constructed for each treatment at the parental, 3rd, 6th, and 9th generations. Standard quality control parameters (pupation at 24 h, pupal weight, adult emergence, and flight ability), were estimated for each treatment every third generation in the third year. For the last generation each year, mating competitiveness was evaluated in field cage tests

  2. Exercise holds immediate benefits for affect and cognition in younger and older adults.

    Science.gov (United States)

    Hogan, Candice L; Mata, Jutta; Carstensen, Laura L

    2013-06-01

    Physical activity is associated with improved affective experience and enhanced cognitive processing. Potential age differences in the degree of benefit, however, are poorly understood because most studies examine either younger or older adults. The present study examined age differences in cognitive performance and affective experience immediately following a single bout of moderate exercise. Participants (144 community members aged 19 to 93) were randomly assigned to one of two experimental conditions: (a) exercise (15 min of moderate intensity stationary cycling) or (b) control (15 min completing ratings of neutral IAPS images). Before and after the manipulation, participants completed tests of working memory and momentary affect experience was measured. Results suggest that exercise is associated with increased levels of high-arousal positive affect (HAP) and decreased levels of low-arousal positive affect (LAP) relative to control condition. Age moderated the effects of exercise on LAP, such that younger age was associated with a drop in reported LAP postexercise, whereas the effects of exercise on HAP were consistent across age. Exercise also led to faster RTs on a working memory task than the control condition across age. Self-reported negative affect was unchanged. Overall, findings suggest that exercise may hold important benefits for both affective experience and cognitive performance regardless of age. PMID:23795769

  3. Treatment of Chronic Breath-Holding in an Adult with Severe Mental Retardation: A Clinical Case Study

    Science.gov (United States)

    Reed, Derek D.; Martens, Brian K.

    2008-01-01

    We describe a clinical case study surrounding the behavioral assessment and operant treatment of, an adult with severe mental retardation who engaged in chronic breath-holding. In this clinical case, previous neurological and medical testing had ruled out biological bases for the individual's breath-holding. A functional behavioral assessment…

  4. Chronic conditions in adults with cerebral palsy

    OpenAIRE

    Peterson, MD; Ryan, JM; Hurvitz, EA; E Mahmoudi

    2015-01-01

    Adults with cerebral palsy (CP) represent a growing population whose health status and healthcare needs are poorly understood.1 Mortality records reveal that death due to ischemic heart disease and cancer is higher among adults with CP;2 however, there have been no national surveillance efforts to track disease risk in this population. We examined estimates of chronic conditions in a population-representative sample of adults with CP.

  5. When Distraction Holds Relevance: A Prospective Memory Benefit for Older Adults

    Directory of Open Access Journals (Sweden)

    Joana S. Lourenço

    2015-06-01

    Full Text Available Evidence is accumulating to show that age-related increases in susceptibility to distracting information can benefit older more than young adults in several cognitive tasks. Here we focus on prospective memory (i.e., remembering to carry out future intentions and examine the effect of presenting distracting information that is intention-related as a function of age. Young and older adults performed an ongoing 1-back working memory task to a rapid stream of pictures superimposed with to-be-ignored letter strings. Participants were additionally instructed to respond to target pictures (namely, animals and, for half of the participants, some strings prior to the targets were intention-related words (i.e., animals. Results showed that presenting intention-related distracting information during the ongoing task was particularly advantageous for target detection in older compared to young adults. Moreover, a prospective memory benefit was observed even for older adults who showed no explicit memory for the target distracter words. We speculate that intention-related distracter information enhanced the accessibility of the prospective memory task and suggest that when distracting information holds relevance to intentions it can serve a compensatory role in prospective remembering in older adults.

  6. Discrimination among adults with craniofacial conditions.

    Science.gov (United States)

    Roberts, Rachel M

    2014-01-01

    The primary goal of this study was to establish the level of perceived discrimination experienced by adults with congenital craniofacial conditions in Australia and to examine predictors of discrimination. Specifically, this study tested whether social support mediates the relationship between discrimination and health. Adults (n = 93) who had been treated at the Australian Craniofacial Unit, Women's and Children's Hospital, Adelaide for congenital craniofacial conditions (not including cleft lip and/or palate) completed questionnaires examining satisfaction with life, quality of life, anxiety and depression, self-esteem, satisfaction with social support, and satisfaction with appearance. A substantial minority of adults with congenital craniofacial conditions reported that they experience discrimination almost every day in a range of areas. Higher reports of discrimination were related to older age, being male, and less education. Other factors related to higher discrimination included lower levels of satisfaction with life, self-esteem, satisfaction with appearance and mental quality of life, as well as higher levels of anxiety and depression. Social support partially mediated the relationship between discrimination and mental health outcomes. The current study shows that discrimination experiences continue into adulthood confirming the importance of ensuring patients are well supported both by psychosocial services as well as within their own social support networks. PMID:24240765

  7. Modelling of fatigue crack growth in Inconel 718 under hold time conditions - application to a flight spectrum

    OpenAIRE

    Lundström, Erik; Simonsson, Kjell; Månsson, Tomas; Gustafsson, David

    2014-01-01

    Gas turbine operating cycles at high temperatures often consist of load reversals mixed with hold times; the latter occurring either as cruise for aero engines or at continuous power output for land based turbines, but also at low frequency loading conditions, e.g. slow “ramp up” of engine thrust. The hold time conditions cause the crack to grow by intergranular fracture due to material damage near the crack tip, thus rapidly increasing the crack growth rate. Since the damaged zone will affec...

  8. Sensory Over-Responsivity in Adults with Autism Spectrum Conditions

    Science.gov (United States)

    Tavassoli, Teresa; Miller, Lucy J.; Schoen, Sarah A.; Nielsen, Darci M.; Baron-Cohen, Simon

    2014-01-01

    Anecdotal reports and empirical evidence suggest that sensory processing issues are a key feature of autism spectrum conditions. This study set out to investigate whether adults with autism spectrum conditions report more sensory over-responsivity than adults without autism spectrum conditions. Another goal of the study was to identify whether…

  9. Multiple Chronic Conditions Among US Adults: A 2012 Update

    OpenAIRE

    Ward, Brian W.; Schiller, Jeannine S.; Goodman, Richard A.

    2014-01-01

    The objective of this research was to update earlier estimates of prevalence rates of single chronic conditions and multiple (>2) chronic conditions (MCC) among the noninstitutionalized, civilian US adult population. Data from the 2012 National Health Interview Survey (NHIS) were used to generate estimates of MCC for US adults and by select demographic characteristics. Approximately half (117 million) of US adults have at least one of the 10 chronic conditions examined (ie, hypertension, coro...

  10. When Distraction Holds Relevance: A Prospective Memory Benefit for Older Adults

    OpenAIRE

    Lourenço, Joana S.; Maylor, Elizabeth A

    2015-01-01

    Evidence is accumulating to show that age-related increases in susceptibility to distracting information can benefit older more than young adults in several cognitive tasks. Here we focus on prospective memory (i.e., remembering to carry out future intentions) and examine the effect of presenting distracting information that is intention-related as a function of age. Young and older adults performed an ongoing 1-back working memory task to a rapid stream of pictures superimposed with to-be-...

  11. Exercise Holds Immediate Benefits for Affect and Cognition in Younger and Older Adults

    OpenAIRE

    Hogan, Candice L.; Mata, Jutta; Carstensen, Laura L.

    2013-01-01

    Physical activity is associated with improved affective experience and enhanced cognitive processing. Potential age differences in the degree of benefit, however, are poorly understood because most studies examine either younger or older adults. The present study examined age differences in cognitive performance and affective experience immediately following a single bout of moderate exercise. Participants (144 community members aged 19 to 93) were randomly assigned to one of two experimental...

  12. The beliefs adults and children hold about television and video games.

    Science.gov (United States)

    Sneed, C; Runco, M A

    1992-05-01

    In Phase 1 of this study, we asked 23 parents between the ages of 30 and 52 years and 26 children between the ages of 10 and 19 years to list effects of television and video games on children. A questionnaire was developed using the most frequently given responses (e.g., television influences children's aggressive behavior, verbal abilities, or time with friends). In Phase 2, this questionnaire was administered to different groups of parents and children and a control group of adults without offspring (N = 204) who were asked to rate the influence of each item on the questionnaire. Multivariate analyses of variance indicated that there were similarities and differences among the groups. For example, parents and other adults held similar beliefs about the influence of television, but parents held more positive beliefs about the influence of video games than the other adults. Children held more positive beliefs about the influence of television than parents, but parents and children held similar beliefs about the influence of video games. PMID:1527774

  13. Crack growth threshold under hold time conditions in DA Inconel 718 – A transition in the crack growth mechanism

    Directory of Open Access Journals (Sweden)

    E. Fessler

    2016-01-01

    Full Text Available Aeroengine manufacturers have to demonstrate that critical components such as turbine disks, made of DA Inconel 718, meet the certification requirements in term of fatigue crack growth. In order to be more representative of the in service loading conditions, crack growth under hold time conditions is studied. Modelling crack growth under these conditions is challenging due to the combined effect of fatigue, creep and environment. Under these conditions, established models are often conservative but the degree of conservatism can be reduced by introducing the crack growth threshold in models. Here, the emphasis is laid on the characterization of crack growth rates in the low ΔK regime under hold time conditions and in particular, on the involved crack growth mechanism. Crack growth tests were carried out at high temperature (550 °C to 650 °C under hold time conditions (up to 1200 s in the low ΔK regime using a K-decreasing procedure. Scanning electron microscopy was used to identify the fracture mode involved in the low ΔK regime. EBSD analyses and BSE imaging were also carried out along the crack path for a more accurate identification of the fracture mode. A transition from intergranular to transgranular fracture was evidenced in the low ΔK regime and slip bands have also been observed at the tip of an arrested crack at low ΔK. Transgranular fracture and slip bands are usually observed under pure fatigue loading conditions. At low ΔK, hold time cycles are believed to act as equivalent pure fatigue cycles. This change in the crack growth mechanism under hold time conditions at low ΔK is discussed regarding results related to intergranular crack tip oxidation and its effect on the crack growth behaviour of Inconel 718 alloy. A concept based on an “effective oxygen partial pressure” at the crack tip is proposed to explain the transition from transgranular to intergranular fracture in the low ΔK regime.

  14. Modelling of high temperature fatigue crack growth in Inconel 718 under hold time conditions

    OpenAIRE

    Gustafsson, David; Lundström, Erik; Simonsson, Kjell

    2013-01-01

    Inconel 718 is a frequently used material for gas turbine applications at temperatures up to 650 °C. The main load cycle for such components is typically defined by the start-up and shut-down of the engine. It generally includes hold times at high temperatures, which have been found to have a potential for greatly increasing the fatigue crack growth rate with respect to the number of load cycles. However, these effects may be totally or partly cancelled by other load features, such as overloa...

  15. Conditional cash transfers, adult work incentives, and poverty

    OpenAIRE

    Skoufias, Emmanuel; Di Maro,Vincenzo

    2006-01-01

    Conditional cash transfer (CCT) programs aim to alleviate poverty through monetary and in-kind benefits, as well as reduce future levels of poverty by encouraging investments in education, health, and nutrition. The success of CCT programs at reducing poverty depends on whether, and the extent to which, cash transfers affect adult work incentives. The authors examine whether the PROGRESA program of Mexico affects adult participation in the labor market and overall adult leisure time, and they...

  16. Effect of Holding Conditions on the Detection of Chikungunya and Venezuelan Equine Encephalitis Viruses in Mosquito Pools.

    Science.gov (United States)

    Andrews, Elizabeth S; Turell, Michael J

    2016-03-01

    Emerging and re-emerging arboviruses continue to be a threat to global public health, and viral surveillance of mosquito populations is critical for mosquito control operations. Due to the tropical climate of many of the affected areas, it may be difficult to maintain a cold chain as the samples travel from collection sites to laboratories for testing. We determined how suboptimal holding temperatures affected the ability to detect viruses in pools of mosquitoes. Adult female Aedes albopictus and Ae. taeniorhynchus individuals were inoculated with chikungunya virus or Venezuelan equine encephalitis virus suspensions, respectively, and placed at 26°C for 8 days. One infected mosquito was then added to a vial of 24 negative mosquitoes and held at -80°C, -20°C, 4°C, 22°C, or 35°C for up to 14 days. Mosquito pools were analyzed for both infectious virus by plaque assay and for viral ribonucleic acid (RNA) with reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR). At higher temperatures, the amount of infectious virus decreased rapidly, but viruses in samples held at 4°C or lower remained relatively stable. In contrast, viral RNA was detectable from pools held at all temperatures and holding times by RT-qPCR. Cycle threshold (Ct) values increased as temperatures and holding times increased. These findings suggest that if viral RNA detection is the goal of surveillance efforts, then mosquito pools do not require storage at ≤4°C. This enhances the feasibility of field-based arbovirus surveillance programs in which maintaining a cold chain may not be a possibility. PMID:27105216

  17. Adult beetles compensate for poor larval food conditions.

    Science.gov (United States)

    Müller, Thorben; Müller, Caroline

    2016-05-01

    Life history traits of herbivores are highly influenced by the quality of their hosts, i.e., the composition of primary and secondary plant metabolites. In holometabolous insects, larvae and adults may face different host plants, which differ in quality. It has been hypothesised that adult fitness is either highest when larval and adult environmental conditions match (environmental matching) or it may be mainly determined by optimal larval conditions (silver spoon effect). Alternatively, the adult stage may be most decisive for the actual fitness, independent of larval food exposure, due to adult compensation ability. To determine the influence of constant versus changing larval and adult host plant experiences on growth performance, fitness and feeding preferences, we carried out a match-mismatch experiment using the mustard leaf beetle, Phaedon cochleariae. Larvae and adults were either constantly reared on watercress (natural host) or cabbage (crop plant) or were switched after metamorphosis to the other host. Growth, reproductive traits and feeding preferences were determined repeatedly over lifetime and host plant quality traits analysed. Differences in the host quality led to differences in the development time and female reproduction. Egg numbers were significantly influenced by the host plant species experienced by the adults. Thus, adults were able to compensate for poor larval conditions. Likewise, the current host experience was most decisive for feeding preferences; in adult beetles a feeding preference was shaped regardless of the larval host plant. Larvae or adults reared on the more nutritious host, cabbage, showed a higher preference for this host. Hence, beetles most likely develop a preference when gaining a direct positive feedback in terms of an improved performance, whereby the current experience matters the most. Highly nutritious crop plants may be, in consequence, all the more exploited by potential pests that may show a high plasticity in

  18. Vascular regulation of adult neurogenesis under physiological and pathological conditions

    Directory of Open Access Journals (Sweden)

    Masato eSawada

    2014-03-01

    Full Text Available Neural stem cells in the mammalian adult brain continuously produce new neurons throughout life. Accumulating evidence in rodents suggests that various aspects of adult neurogenesis, including the genesis, migration, and maturation of new neurons, are regulated by factors derived from blood vessels and their microenvironment. Brain injury enhances both neurogenesis and angiogenesis, thereby promoting the cooperative regeneration of neurons and blood vessels. In this paper, we briefly review the mechanisms for the vascular regulation of adult neurogenesis in the ventricular-subventricular zone under physiological and pathological conditions, and discuss their clinical potential for brain regeneration strategies.

  19. Analysis of Conditional Value-at-Risk for Newsvendor with Holding and Backorder Cost under Market Search

    Institute of Scientific and Technical Information of China (English)

    LI Jianbin; GAO Chengxiu; HU Wei; YANG Lei

    2007-01-01

    We consider a distribution system with one supplier and two retailers. For the two retailers, they face different demand and are both risk averse. We study a single period model which the supplier has ample goods and the retailers order goods separately. Market search is measured as the fraction of customers who unsatisfied with their "local" retailer due to stock-out, and search for the goods at the other retailer before leaving the system. We investigate how the retailers game for order quantity in a Conditional Value-at-Risk framework and study how risk averse degree, market search level,holding cost and backorder cost influence the optimal order strategies. Furthermore, we use uniform distribution to illustrate these results and obtain Nash equilibrium of order strategies.

  20. Multiple Chronic Conditions in Older Adults with Acute Coronary Syndromes.

    Science.gov (United States)

    Alfredsson, Joakim; Alexander, Karen P

    2016-05-01

    Older adults presenting with acute coronary syndromes (ACSs) often have multiple chronic conditions (MCCs). In addition to traditional cardiovascular (CV) risk factors (ie, hypertension, hyperlipidemia, and diabetes), common CV comorbidities include heart failure, stroke, and atrial fibrillation, whereas prevalent non-CV comorbidities include chronic kidney disease, anemia, depression, and chronic obstructive pulmonary disease. The presence of MCCs affects the presentation (eg, increased frequency of type 2 myocardial infarctions [MIs]), clinical course, and prognosis of ACS in older adults. In general, higher comorbidity burden increases mortality following MI, reduces utilization of ACS treatments, and increases the importance of developing individualized treatment plans. PMID:27113147

  1. Study of Water-holding Indicators of Various Environmental Groups of Trees and Shrubs under Zhezkazgan Region Conditions

    Directory of Open Access Journals (Sweden)

    Alexandra Sh. Dodonova

    2013-01-01

    Full Text Available The article studies water content of leaves and water-holding capacity of trees and shrubs of twelve kinds of plants. Water-holding capacity analysis was conducted in summer, which is stressful for the plants. It was determined that water-holding capacity of plants is minimal in spring and summer, while these functions increase in mid and late summer. Basing on these data, all trees and shrubs were divided into 3 groups by water-holding capacity: low, medium and high. Plants of the third group are recommended for the semi-arid zone Zhezkazgan Region landscaping.

  2. Improving efficacy of the sterile insect technique by incorporation of hormone and dietary supplements into adult holding protocols

    International Nuclear Information System (INIS)

    Full text: One of the most effective and environmentally sound methods for suppression or eradication of pest insects is the Sterile Insect Technique (SIT) pioneered by E. F. Knipling. It was first implemented effectively to eradicate the screwworm fly from Florida and since has been used to control numerous lepidopteran and dipteran pests. Control is achieved in SIT by mass-release of sterile males who mate with wild females. Females that mate with sterile males do not produce viable eggs that over time, results in population decline and suppression or eventual eradication. The key to optimising efficacy of SIT is to produce sterile males that compete as well as, or out-compete, wild males in mating opportunities with wild females. Although SIT is an effective control tool, it is expensive in terms of both money and time, thus cost benefits must be clearly defined in order to balance the needs for effective control with funding constraints. One of the more significant costs associated with SIT protocols is that frequently males require many days to become sexually mature. For example males of many of Tephritid and tsetse fly species require 7 days to become fully mature. If males are held for several days prior to release, costs of holding are high and mortality prior to release and mating reduces the effective number of sterile males available. One way of improving efficacy of SIT management protocols is to develop methods to accelerate reproductive development in sterile males, while still optimising reproductive performance. Developing ways to effectively accelerate reproductive development of sterile males while insuring that males are capable of competing effectively against wild males for mating with wild females requires a thorough knowledge of the endogenous mechanists that regulate reproductive development and sexual signaling. However, few studies have been conducted on the endogenous regulation of sexual maturity and signaling in male insects. Our

  3. Alcohol Consumption, Medical Conditions, and Health Behavior in Older Adults

    OpenAIRE

    Satre, Derek; Nancy P. Gordon; Weisner, Constance

    2007-01-01

    Objectives: To examine associations between drinking patterns, medical conditions and behavioral health risks among older adults. Methods: Analyses compared survey participants (health plan members ages 65 to 90, N = 6,662) who drank moderately to those who drank over recommended limits or did not drink. Results: Over-limit drinking was associated with smoking; not trying to eat low fat foods (in men), and lower BMI (in women). Predictors of not drinking during the prior 12 months included...

  4. Effects of different drying conditions on the rehydration ratio and water holding capacity properties in three different species of algae Ulva lactuca, Codium vermilara and Codium tomentosum

    Directory of Open Access Journals (Sweden)

    Paulo Marques Nunes

    2014-06-01

    In this work, it was concluded that higher drying temperature conditions originate lower rehydration ratio and consequent lower water holding capacity possibly due to a higher physical damage in the algae tissues. It was also observed that both Codium species have higher values for these two parameters than Ulva lactuca, under the same rehydration conditions.

  5. Assisting the Adult with a Respiratory Condition: Pharmacology. Care of the Adult.

    Science.gov (United States)

    Anoka-Hennepin Area Vocational Technical Inst., MN.

    These two units for students in a practical nursing program provide supplemental instruction, with a focus on pharmacology, in caring for adult patients with a respiratory condition. Unit titles are Antibiotics, and Drugs that Affect the Respiratory System. Each unit contains the following: objectives, an introduction, and five to nine learning…

  6. Reality Monitoring and Metamemory in Adults with Autism Spectrum Conditions.

    Science.gov (United States)

    Cooper, Rose A; Plaisted-Grant, Kate C; Baron-Cohen, Simon; Simons, Jon S

    2016-06-01

    Studies of reality monitoring (RM) often implicate medial prefrontal cortex (mPFC) in distinguishing internal and external information, a region linked to autism-related deficits in social and self-referential information processing, executive function, and memory. This study used two RM conditions (self-other; perceived-imagined) to investigate RM and metamemory in adults with autism. The autism group showed a deficit in RM, which did not differ across source conditions, and both groups exhibited a self-encoding benefit on recognition and source memory. Metamemory for perceived-imagined information, but not for self-other information, was significantly lower in the autism group. Therefore, reality monitoring and metamemory, sensitive to mPFC function, appear impaired in autism, highlighting a difficulty in remembering and monitoring internal and external details of past events. PMID:26899724

  7. Adult vultures outperform juveniles in challenging thermal soaring conditions

    Science.gov (United States)

    Harel, Roi; Horvitz, Nir; Nathan, Ran

    2016-01-01

    Due to the potentially detrimental consequences of low performance in basic functional tasks, individuals are expected to improve performance with age and show the most marked changes during early stages of life. Soaring-gliding birds use rising-air columns (thermals) to reduce energy expenditure allocated to flight. We offer a framework to evaluate thermal soaring performance, and use GPS-tracking to study movements of Eurasian griffon vultures (Gyps fulvus). Because the location and intensity of thermals are variable, we hypothesized that soaring performance would improve with experience and predicted that the performance of inexperienced individuals (5 years). No differences were found in body characteristics, climb rates under low wind shear, and thermal selection, presumably due to vultures’ tendency to forage in mixed-age groups. Adults, however, outperformed juveniles in their ability to adjust fine-scale movements under challenging conditions, as juveniles had lower climb rates under intermediate wind shear, particularly on the lee-side of thermal columns. Juveniles were also less efficient along the route both in terms of time and energy. The consequences of these handicaps are probably exacerbated if juveniles lag behind adults in finding and approaching food. PMID:27291590

  8. Identifying the lost generation of adults with autism spectrum conditions.

    Science.gov (United States)

    Lai, Meng-Chuan; Baron-Cohen, Simon

    2015-11-01

    Autism spectrum conditions comprise a set of early-onset neurodevelopmental syndromes with a prevalence of 1% across all ages. First diagnosis in adulthood has finally become recognised as an important clinical issue due to the increasing awareness of autism, broadening of diagnostic criteria, and the introduction of the spectrum concept. Thus, the idea of a lost generation of people who were previously excluded from a diagnosis of classic autism has arisen. Making a first diagnosis of autism spectrum conditions in adults can be challenging for practical reasons (eg, no person to provide a developmental history), developmental reasons (eg, the acquisition of learnt or camouflaging strategies), and clinical reasons (eg, high frequency of co-occurring disorders). The diagnostic process includes referral, screening, interviews with informants and patients, and functional assessments. In delineating differential diagnoses, true comorbidities, and overlapping behaviour with other psychiatric diagnoses, particular attention should be paid to anxiety, depression, obsessive-compulsive disorder, psychosis, personality disorders, and other neurodevelopmental disorders. Possible misdiagnosis, especially in women, should be explored. The creation of supportive, accepting, and autism-friendly social and physical environments is important and requires a coordinated effort across agencies and needs support from government policies. PMID:26544750

  9. 17 CFR 240.15c3-1g - Conditions for ultimate holding companies of certain brokers or dealers (Appendix G to 17 CFR 240...

    Science.gov (United States)

    2010-04-01

    ... application under § 240.15c3-1e(a)). (B) A graph reflecting, for each business line, the daily intra-month VaR... holding companies of certain brokers or dealers (Appendix G to 17 CFR 240.15c3-1). 240.15c3-1g Section 240... companies of certain brokers or dealers (Appendix G to 17 CFR 240.15c3-1). As a condition for a broker...

  10. The Effects of Childhood, Adult, and Community Socioeconomic Conditions on Health and Mortality among Older Adults in China

    OpenAIRE

    Wen, Ming; Gu, Danan

    2011-01-01

    Using a large, nationally representative longitudinal sample of Chinese aged 65 and older, this study examines the effects of childhood, adult, and community socioeconomic conditions on mortality and several major health outcomes. The role of social mobility is also tested. We find that childhood socioeconomic conditions exert long-term effects on functional limitations, cognitive impairment, self-rated health, and mortality independent of adult and community socioeconomic conditions. Achieve...

  11. Selected Diagnosed Chronic Conditions by Sexual Orientation: A National Study of US Adults, 2013

    OpenAIRE

    Ward, Brian W.; Joestl, Sarah S.; Adena M. Galinsky; Dahlhamer, James M.

    2015-01-01

    Introduction Research is needed on chronic health conditions among lesbian, gay, and bisexual populations. The objective of this study was to examine 10 diagnosed chronic conditions, and multiple (≥2) chronic conditions (MCC), by sexual orientation among US adults. Methods The 2013 National Health Interview Survey was used to generate age-adjusted prevalence rates and adjusted odds ratios of diagnosed chronic conditions and MCC for civilian, noninstitutionalized US adults who identified as ga...

  12. Pathways from childhood abuse and other adversities to adult health risks: The role of adult socioeconomic conditions.

    Science.gov (United States)

    Font, Sarah A; Maguire-Jack, Kathryn

    2016-01-01

    Adverse childhood experiences (ACEs), including child abuse, have been linked with poor health outcomes in adulthood. The mechanisms that explain these relations are less understood. This study assesses whether associations of ACEs and health risks are mediated by adult socioeconomic conditions, and whether these pathways are different for maltreatment than for other types of adversities. Using the Behavioral Risk Factor Surveillance System 2012 survey (N=29,229), we employ structural equation modeling to (1) estimate associations of the number and type of ACEs with five health risks-depression, obesity, tobacco use, binge drinking, and self-reported sub-optimal health; and (2) assess whether adult socioeconomic conditions-marriage, divorce and separation, educational attainment, income and insurance status-mediate those associations. Findings suggest both direct and indirect associations between ACEs and health risks. At high numbers of ACEs, 15-20% of the association between number of ACEs and adult health risks was attributable to socioeconomic conditions. Associations of three ACEs (exposure to domestic violence, parental divorce, and residing with a person who was incarcerated) with health risks were nearly entirely explained by socioeconomic conditions in adulthood. However, child physical, emotional, and sexual abuse were significantly associated with several adult health risks, beyond the effects of other adversities, and socioeconomic conditions explained only a small portion of these associations. These findings suggest that the pathways to poor adult health differ by types of ACEs, and that childhood abuse is more likely than other adversities to have a direct impact. PMID:26059537

  13. Classification of Older Adults Who Have Diabetes by Comorbid Conditions, United States, 2005–2006

    OpenAIRE

    Laiteerapong, Neda; Iveniuk, James; John, Priya M.; Laumann, Edward O.; Huang, Elbert S.

    2012-01-01

    Introduction Older adults who have diabetes vary widely in terms of comorbid conditions; these conditions help determine the risks and benefits of intensive glycemic control. Not all people benefit from intensive glycemic control. The objective of this study was to classify by comorbid conditions older American adults who have diabetes to identify those who are less likely to benefit from intensive glycemic control. Methods We used latent class analysis to identify subgroups of a nationally r...

  14. Effects of the hold and relax-agonist contraction technique on recovery from delayed onset muscle soreness after exercise in healthy adults

    OpenAIRE

    Cha, Hyun-Gyu; Kim, Myoung-Kwon

    2015-01-01

    [Purpose] This study was conducted to verify the effects of the hold relax-agonist contraction and passive straight leg raising techniques on muscle activity, fatigue, and range of motion of the hip joint after the induction of delayed onset muscle soreness in the hamstring muscle. [Subjects] Sixty subjects were randomly assigned to a hold relax-agonist contraction group and a passive straight leg raising group. [Methods] Subjects in the experimental group underwent hold relax-agonist contrac...

  15. Assessment of reproducibility and stability of different breath-hold maneuvres by dynamic MRI: comparison between healthy adults and patients with pulmonary hypertension

    International Nuclear Information System (INIS)

    To assess the stability and reproducibility of different breath-hold levels in healthy volunteers and patients using dynamic MRI (dMRI). In ten healthy volunteers and ten patients with pulmonary hypertension (PH) and normal lung function craniocaudal intrathoracic distances (CCD) were measured during inspiratory and expiratory breath-hold (15 s) (in healthy volunteers additionally at a self-chosen mid-inspiratory breath-hold) using dMRI (trueFISP, three images/s). To evaluate stability and intraobserver reproducibility of the different breath-hold levels, CCDs, time-distance curves, confidence intervals (CIs), Mann-Witney U test and regression equations were calculated. In healthy volunteers there was a substantial decrease of the CCD during the inspiratory breath-hold in contrast to the expiratory breath-hold. The CI at inspiration was 2.84±1.28 in the right and 2.1±0.68 in the left hemithorax. At expiration the CI was 2.54±1.18 and 2.8±1.48. Patients were significantly less able to hold their breath at inspiration than controls (P<0.05). In patients CI was 4.53±4.06 and 3.46±2.21 at inspiration and 4.45±4.23 and 4.76±3.73 at expiration. Intraobserver variability showed no significant differences either in patients or in healthy subjects. Reproducibility was significantly lower at a self-chosen breath-hold level of the healthy volunteers. DMRI is able to differentiate stability and reproducibility of different breath-hold levels. Expiratory breath-hold proved to be more stable than inspiratory breath-hold in healthy volunteers and patients. (orig.)

  16. Assessment of reproducibility and stability of different breath-hold maneuvres by dynamic MRI: comparison between healthy adults and patients with pulmonary hypertension

    Energy Technology Data Exchange (ETDEWEB)

    Plathow, Christian [German Cancer Research Center Heidelberg, Department of Radiology, Heidelberg (Germany); Eberhard-Karls-University Tuebingen, Department of Diagnostic Radiology, Tuebingen (Germany); Ley, Sebastian; Zaporozhan, Julia; Puderbach, Michael; Eichinger, Monika; Zuna, Ivan; Kauczor, Hans-Ulrich [German Cancer Research Center Heidelberg, Department of Radiology, Heidelberg (Germany); Schoebinger, Max; Meinzer, Hans-Peter [German Cancer Research Center Heidelberg, Department of Medical and Biological Informatics, Heidelberg (Germany); Gruenig, Ekkehard [University of Heidelberg, Department of Internal Medicine III, Heidelberg (Germany)

    2006-01-01

    To assess the stability and reproducibility of different breath-hold levels in healthy volunteers and patients using dynamic MRI (dMRI). In ten healthy volunteers and ten patients with pulmonary hypertension (PH) and normal lung function craniocaudal intrathoracic distances (CCD) were measured during inspiratory and expiratory breath-hold (15 s) (in healthy volunteers additionally at a self-chosen mid-inspiratory breath-hold) using dMRI (trueFISP, three images/s). To evaluate stability and intraobserver reproducibility of the different breath-hold levels, CCDs, time-distance curves, confidence intervals (CIs), Mann-Witney U test and regression equations were calculated. In healthy volunteers there was a substantial decrease of the CCD during the inspiratory breath-hold in contrast to the expiratory breath-hold. The CI at inspiration was 2.84{+-}1.28 in the right and 2.1{+-}0.68 in the left hemithorax. At expiration the CI was 2.54{+-}1.18 and 2.8{+-}1.48. Patients were significantly less able to hold their breath at inspiration than controls (P<0.05). In patients CI was 4.53{+-}4.06 and 3.46{+-}2.21 at inspiration and 4.45{+-}4.23 and 4.76{+-}3.73 at expiration. Intraobserver variability showed no significant differences either in patients or in healthy subjects. Reproducibility was significantly lower at a self-chosen breath-hold level of the healthy volunteers. DMRI is able to differentiate stability and reproducibility of different breath-hold levels. Expiratory breath-hold proved to be more stable than inspiratory breath-hold in healthy volunteers and patients. (orig.)

  17. Acceptance of Conditional Suicide and Euthanasia among Adult Americans.

    Science.gov (United States)

    Johnson, David; And Others

    1980-01-01

    Analysis indicates that religious intensity, sex, age, and education are important associational variables regarding attitudes toward suicide and euthanasia. Males are more accepting than females. Females are influenced by family life conditions. Males are influenced by health status. (JMF)

  18. Multiple Chronic Conditions among Adults Aged 45 and Over: Trends Over the Past 10 Years

    Science.gov (United States)

    ... needs and use for Medicare and other payers. Keywords: hypertension, diabetes, cancer, prevalence The percentage of adults ... with two or more chronic conditions had increasing difficulty obtaining needed medical care and prescription drugs because ...

  19. Childhood and adult social conditions and risk of stroke

    OpenAIRE

    Grau, Armin J.; Ling, Paul; Palm, Frederik; Urbanek, Christian; Becher, Heiko; Buggle, Florian

    2012-01-01

    Background: Socioeconomic conditions may strongly influence the risk of stroke. We tested the hypotheses that indexes of social status in different life periods including childhood are inversely associated with stroke risk and that there is a cumulative effect of social conditions during lifetime on the risk of stroke. Furthermore, we investigated whether social advancement compared to the parental generation is associated with reduced stroke risk. Methods: In a case-control study, we assesse...

  20. Prenatal Choline Availability Alters the Context Sensitivity of Pavlovian Conditioning in Adult Rats

    Science.gov (United States)

    Lamoureux, Jeffrey A.; Meck, Warren H.; Williams, Christina L.

    2008-01-01

    The effects of prenatal choline availability on Pavlovian conditioning were assessed in adult male rats (3-4 mo). Neither supplementation nor deprivation of prenatal choline affected the acquisition and extinction of simple Pavlovian conditioned excitation, or the acquisition and retardation of conditioned inhibition. However, prenatal choline…

  1. Holding fast.

    Science.gov (United States)

    Gourville, John T

    2005-06-01

    CEO Peter Walsh faces a classic innovator's dilemma. His company, Crescordia, produces high-quality metal plates, pins, and screws that orthopedic surgeons use to repair broken bones. In fact, because the company has for decades refused to compromise on quality, there are orthopedic surgeons who use nothing but Crescordia hardware. And now these customers have begun to clamor for the next generation technology: resorbable hardware. Resorbables offer clear advantages over the traditional hardware. Like dissolving sutures, resorbable plates and screws are made of biodegradable polymers. They hold up long enough to support a healing bone, then gradually and harmlessly disintegrate in the patient's body. Surgeons are especially looking forward to using resorbables on children, so kids won't have to undergo a second operation to remove the old hardware after their bones heal, a common procedure in pediatrics. The new products, however, are not yet reliable; they fail about 8% of the time, sometimes disintegrating before the bone completely heals and sometimes not ever fully disintegrating. That's why Crescordia, mindful of its hard-earned reputation, has delayed launching a line using the new technology. But time is running out. A few competitors have begun to sell resorbables despite their imperfections, and these companies are picking up market share. Should Crescordia join the fray and risk tarnishing its brand? Or should the company sit tight until it can offer a perfect product? Commenting on this fictional case study are Robert A. Lutz, vice chairman of product development at General Motors; Clayton M. Christensen, the Robert and Jane Cizik Professor of Business Administration at Harvard Business School; Jason Wittes, a senior equity analyst covering medical supplies and devices at Leerink Swann; and Nick Galakatos, a general partner of MPM Capital. PMID:15938437

  2. Participation and Well-Being Among Older Adults Living with Chronic Conditions

    OpenAIRE

    Anaby, D.; Miller, W C; Jarus, T.; Eng, J. J.; Noreau, L

    2011-01-01

    This study explored the unique contribution of participation (daily activities and social roles) in explaining well-being of older adults living with chronic conditions and examined which aspect of participation (accomplishment of participation or satisfaction with participation) was more important in describing their well-being. Two hundred older adults with chronic conditions completed the following assessments: Satisfaction with Life Scale to measure well-being; Assessment of Life Habits t...

  3. Primary Care of Adult Women: Common Dermatologic Conditions.

    Science.gov (United States)

    Ruiz de Luzuriaga, Arlene M; Mhlaba, Julie; Roman, Carly

    2016-06-01

    Dermatologic disease often presents in the primary care setting. Therefore, it is important for the primary care provider to be familiar with the presentation, diagnosis, and treatment of common skin conditions. This article provides an overview of acne, rosacea, melasma, vitiligo, alopecia, nonmelanoma, and melanoma skin cancer, dermatitis, and lichen sclerosus. PMID:27212088

  4. Reduced-intensity conditioned allogeneic SCT in adults with AML.

    Science.gov (United States)

    Reshef, R; Porter, D L

    2015-06-01

    AML is currently the most common indication for reduced-intensity conditioned (RIC) allo-SCT. Reduced-intensity regimens allow a potent GVL response to occur with minimized treatment-related toxicity in patients of older age or with comorbidities that preclude the use of myeloablative conditioning. Whether RIC SCT is appropriate for younger and more standard risk patients is not well defined and the field is changing rapidly; a prospective randomized trial of myeloablative vs RIC (BMT-CTN 0901) was recently closed when early results indicated better outcomes for myeloablative regimens. However, detailed results are not available, and all patients in that study were eligible for myeloablative conditioning. RIC transplants will likely remain the standard of care as many patients with AML are not eligible for myeloablative conditioning. Recent publication of mature results from retrospective and prospective cohorts provide contemporary efficacy and toxicity data for these attenuated regimens. In addition, recent studies explore the use of alternative donors, introduce regimens that attempt to reduce toxicity without reducing intensity, and identify predictive factors that pave the way to personalized approaches. These studies paint a picture of the future of RIC transplants. Here we review the current status of RIC allogeneic SCT in AML. PMID:25730186

  5. Conditional health threats: health beliefs, decisions, and behaviors among adults.

    Science.gov (United States)

    Ronis, D L

    1992-01-01

    We combined the health belief model with the theory of subjective expected utility to derive hypotheses about the relations among health beliefs and preventive decisions. The central implication of this combination of theories is the importance of conceptualizing, measuring, and communicating about health threats in ways that are clearly conditional on action. It is important to distinguish, for example, between how susceptible to a disease a person thinks he or she would be if that person were and were not to take a preventive action. An experimental study of judgments about a hypothetical preventive action was conducted to test many of the theoretically derived hypotheses. A correlation study of dental flossing behavior was conducted to test the hypotheses as they apply to overt behavior rather than to judgment. Results of both studies supported most of the tested hypotheses, especially those related to the conditional conceptualization of health threats. Implications for theory, research methods, and practical applications are discussed. PMID:1582381

  6. Understanding unskilled work as a condition for participation in adult education and training

    Directory of Open Access Journals (Sweden)

    Sissel Kondrup

    2015-10-01

    Full Text Available This article discusses how to comprehend why people working in unskilled jobs are less likely than other groups to position themselves as educable subjects and engage in adult education and training. The article outlines how different research traditions examining recruitment to and participation in adult education and training reveal and explain distinctive participation patterns. These traditions are critically reviewed to identify how they provide specific understandings as well as certain blind spots. The review reveals a striking absence of research into unskilled work and thus a tendency to overlook how engagement in particular kinds of work condition people's perception of adult education and training. It is finally argued that future research must pay closer attention to people's specific work-life and examine how engagement in specific historical, social and material (changing work practices condition their perception of adult education and training.

  7. Effect of MDMA (ecstasy) on activity and cocaine conditioned place preference in adult and adolescent rats

    OpenAIRE

    Åberg, Maria; Wade, Dean; Wall, Erin; Izenwasser, Sari

    2006-01-01

    MDMA (ecstasy) is a drug commonly used in adolescence, and many users of MDMA also use other illicit drugs. It is not known whether MDMA during adolescence alters subsequent responses to cocaine differently than in adults. This study examined the effects of MDMA in adolescent and adult rats on cocaine conditioned reward. At the start of these experiments, adolescent rats were at postnatal day (PND) 33 and adult rats at PND 60. Each rat was treated for seven days with MDMA (2 or 5 mg/kg/day or...

  8. Health conditions and their impact among adolescents and young adults with Down syndrome.

    Directory of Open Access Journals (Sweden)

    Terri J Pikora

    Full Text Available OBJECTIVE: To examine the prevalence of medical conditions and use of health services among young adults with Down syndrome and describe the impact of these conditions upon their lives. METHODS: Using questionnaire data collected in 2011 from parents of young adults with Down syndrome we investigated the medical conditions experienced by their children in the previous 12 months. Univariate, linear and logistic regression analyses were performed. RESULTS: We found that in addition to the conditions commonly experienced by children with Down syndrome, including eye and vision problems (affecting 73%, ear and hearing problems (affecting 45%, cardiac (affecting 25% and respiratory problems (affecting 36%, conditions also found to be prevalent within our young adult cohort included musculoskeletal conditions (affecting 61%, body weight (affecting 57%, skin (affecting 56% and mental health (affecting 32% conditions and among young women menstrual conditions (affecting 58%. Few parents reported that these conditions had no impact, with common impacts related to restrictions in opportunities to participate in employment and community leisure activities for the young people, as well as safety concerns. CONCLUSION: There is the need to monitor, screen and provide appropriate strategies such as through the promotion of healthy lifestyles to prevent the development of comorbidities in young people with Down syndrome and, where present, to reduce their impact.

  9. Effect of Breath Holding on Spleen Volume Measured by Magnetic Resonance Imaging

    OpenAIRE

    Inoue, Yusuke; Nakajima, Ai; Mizukami, Shinya; Hata, Hirofumi

    2013-01-01

    Objective Ultrasonographic studies have demonstrated transient reduction in spleen volume in relation to apnea diving. We measured spleen volume under various respiratory conditions by MR imaging to accurately determine the influence of ordinary breath holding on spleen volumetry. Materials and Methods Twelve healthy adult volunteers were examined. Contiguous MR images of the spleen were acquired during free breathing and during respiratory manipulations, including breath holding at the end o...

  10. Purine metabolism in response to hypoxic conditions associated with breath-hold diving and exercise in erythrocytes and plasma from bottlenose dolphins (Tursiops truncatus).

    Science.gov (United States)

    del Castillo Velasco-Martínez, Iris; Hernández-Camacho, Claudia J; Méndez-Rodríguez, Lía C; Zenteno-Savín, Tania

    2016-01-01

    In mammalian tissues under hypoxic conditions, ATP degradation results in accumulation of purine metabolites. During exercise, muscle energetic demand increases and oxygen consumption can exceed its supply. During breath-hold diving, oxygen supply is reduced and, although oxygen utilization is regulated by bradycardia (low heart rate) and peripheral vasoconstriction, tissues with low blood flow (ischemia) may become hypoxic. The goal of this study was to evaluate potential differences in the circulating levels of purine metabolism components between diving and exercise in bottlenose dolphins (Tursiops truncatus). Blood samples were taken from captive dolphins following a swimming routine (n=8) and after a 2min dive (n=8). Activity of enzymes involved in purine metabolism (hypoxanthine guanine phosphoribosyl transferase (HGPRT), inosine monophosphate deshydrogenase (IMPDH), xanthine oxidase (XO), purine nucleoside phosphorylase (PNP)), and purine metabolite (hypoxanthine (HX), xanthine (X), uric acid (UA), inosine monophosphate (IMP), inosine, nicotinamide adenine dinucleotide (NAD(+)), adenosine, adenosine monophosphate (AMP), adenosine diphosphate (ADP), ATP, guanosine diphosphate (GDP), guanosine triphosphate (GTP)) concentrations were quantified in erythrocyte and plasma samples. Enzymatic activity and purine metabolite concentrations involved in purine synthesis and degradation, were not significantly different between diving and exercise. Plasma adenosine concentration was higher after diving than exercise (p=0.03); this may be related to dive-induced ischemia. In erythrocytes, HGPRT activity was higher after diving than exercise (p=0.007), suggesting an increased capacity for purine recycling and ATP synthesis from IMP in ischemic tissues of bottlenose dolphins during diving. Purine recycling and physiological adaptations may maintain the ATP concentrations in bottlenose dolphins after diving and exercise. PMID:26506131

  11. The Prevalence of Undiagnosed Geriatric Health Conditions among Adult Protective Service Clients

    Science.gov (United States)

    Heath, John M.; Brown, Merle; Kobylarz, Fred A.; Castano, Susan

    2005-01-01

    Purpose: We sought to determine the prevalence of remediable health conditions from in-home geriatric assessments of referred adult protective service (APS) clients suffering elder mistreatment. Design and Methods: We used a retrospective cohort study of 211 APS clients (74% female; age, M = 77 years) in two central New Jersey counties. Results:…

  12. Developmental aspects of fear: Comparing the acquisition and generalization of conditioned fear in children and adults.

    Science.gov (United States)

    Schiele, Miriam A; Reinhard, Julia; Reif, Andreas; Domschke, Katharina; Romanos, Marcel; Deckert, Jürgen; Pauli, Paul

    2016-05-01

    Most research on human fear conditioning and its generalization has focused on adults whereas only little is known about these processes in children. Direct comparisons between child and adult populations are needed to determine developmental risk markers of fear and anxiety. We compared 267 children and 285 adults in a differential fear conditioning paradigm and generalization test. Skin conductance responses (SCR) and ratings of valence and arousal were obtained to indicate fear learning. Both groups displayed robust and similar differential conditioning on subjective and physiological levels. However, children showed heightened fear generalization compared to adults as indexed by higher arousal ratings and SCR to the generalization stimuli. Results indicate overgeneralization of conditioned fear as a developmental correlate of fear learning. The developmental change from a shallow to a steeper generalization gradient is likely related to the maturation of brain structures that modulate efficient discrimination between danger and (ambiguous) safety cues. © 2016 The Authors. Developmental Psychobiology Published by Wiley Periodicals, Inc. Dev Psychobiol 58: 471-481, 2016. PMID:26798984

  13. Standard methods for maintaining adult Apis mellifera in cages under in vitro laboratory conditions

    NARCIS (Netherlands)

    Williams, G.R.; Alaux, C.; Costa, C.; Csaki, C.; Steen, van der J.J.M.

    2013-01-01

    Adult honey bees are maintained in vitro in laboratory cages for a variety of purposes. For example, researchers may wish to perform experiments on honey bees caged individually or in groups to study aspects of parasitology, toxicology, or physiology under highly controlled conditions, or they may c

  14. Prevalence of Multiple Chronic Conditions Among US Adults: Estimates From the National Health Interview Survey, 2010

    OpenAIRE

    Ward, Brian W.; Schiller, Jeannine S.

    2013-01-01

    Preventing and ameliorating chronic conditions has long been a priority in the United States; however, the increasing recognition that people often have multiple chronic conditions (MCC) has added a layer of complexity with which to contend. The objective of this study was to present the prevalence of MCC and the most common MCC dyads/triads by selected demographic characteristics. We used respondent-reported data from the 2010 National Health Interview Survey (NHIS) to study the US adult civ...

  15. Ablation of mouse adult neurogenesis alters olfactory bulb structure and olfactory fear conditioning

    Directory of Open Access Journals (Sweden)

    Matthew Valley

    2009-11-01

    Full Text Available Adult neurogenesis replenishes olfactory bulb (OB interneurons throughout the life of most mammals, yet during this constant fl ux it remains unclear how the OB maintains a constant structure and function. In the mouse OB, we investigated the dynamics of turnover and its impact on olfactory function by ablating adult neurogenesis with an x-ray lesion to the subventricular zone (SVZ. Regardless of the magnitude of the lesion to the SVZ, we found no change in the survival of young adult born granule cells (GCs born after the lesion, and a gradual decrease in the population of GCs born before the lesion. After a lesion producing a 96% reduction of incoming adult born GCs to the OB, we found a diminished behavioral fear response to conditioned odor cues but not to audio cues. Interestingly, despite this behavioral defi cit and gradual anatomical changes, we found no electrophysiological changes in the GC population assayed in vivo through dendro-dendritic synaptic plasticity and odor-evoked local fi eld potential oscillations. These data indicate that turnover in the granule cell layer is generally decoupled from the rate of adult neurogenesis, and that OB adult neurogenesis plays a role in a wide behavioral system extending beyond the OB.

  16. Factors influencing adult physical health after controlling for current health conditions: evidence from a british cohort.

    Directory of Open Access Journals (Sweden)

    Helen Cheng

    Full Text Available This study explored a longitudinal data set of 6875 British adults examining the effects of parental social status (measured at birth, cognitive ability (at age 11 yrs, personality traits, education and occupational attainment on physical health and functioning (all measured at age 50 yrs, after taking account of current health conditions (number of illness. Correlation analysis showed that parental social class, childhood cognitive ability, education and occupation, and two personality traits (Emotional Stability/Neuroticism, and Conscientiousness were all significantly associated with adult physical health variables. Structural equation modelling showed that health conditions and personality traits were significantly, and inversely, associated with physical health (indicated by good daily physical functioning, relative absence of pain, perceived health, and low level of limitations at work due to physical health. Parental social status, childhood intelligence, educational and occupational attainment were all modestly, but significantly and directly, associated with adult physical health. The effect of childhood intelligence on adult physical health was, in part, mediated through Emotional Stability and Conscientiousness. After controlling for health conditions Emotional Stability was the strongest predictor of physical health. Implications and limitations are discussed.

  17. Understanding unskilled work as a condition for participation in adult education and training

    DEFF Research Database (Denmark)

    Kondrup, Sissel

    2015-01-01

    This article discusses how to comprehend why people working unskilled jobs are less likely than other groups to position themselves as educable subjects and engage in adult education and training. This article outlines how different research traditions examining recruitment to and participation...... a tendency to overlook how engagement in specific kinds of work condition people’s perception of adult education and training. It is finally argued that future research must pay closer attention to people’s specific work-life and examine how engagement in specific historical, social and material (changing...... in adult education and training reveal and explain distinctive participation patterns. These traditions are critically reviewed in order to identify how they provide certain understandings and entail certain blind spots. The review reveals a striking absence of research into unskilled work and thus...

  18. A review of health utilities across conditions common in paediatric and adult populations

    Directory of Open Access Journals (Sweden)

    Hopkins Robert B

    2010-01-01

    Full Text Available Abstract Background Cost-utility analyses are commonly used in economic evaluations of interventions or conditions that have an impact on health-related quality of life. However, evaluating utilities in children presents several challenges since young children may not have the cognitive ability to complete measurement tasks and thus utility values must be estimated by proxy assessors. Another solution is to use utilities derived from an adult population. To better inform the future conduct of cost-utility analyses in paediatric populations, we reviewed the published literature reporting utilities among children and adults across selected conditions common to paediatric and adult populations. Methods An electronic search of Ovid MEDLINE, EMBASE, and the Cochrane Library up to November 2008 was conducted to identify studies presenting utility values derived from the Health Utilities Index (HUI or EuroQoL-5Dimensions (EQ-5D questionnaires or using time trade off (TTO or standard gamble (SG techniques in children and/or adult populations from randomized controlled trials, comparative or non-comparative observational studies, or cross-sectional studies. The search was targeted to four chronic diseases/conditions common to both children and adults and known to have a negative impact on health-related quality of life (HRQoL. Results After screening 951 citations identified from the literature search, 77 unique studies included in our review evaluated utilities in patients with asthma (n = 25, cancer (n = 23, diabetes mellitus (n = 11, skin diseases (n = 19 or chronic diseases (n = 2, with some studies evaluating multiple conditions. Utility values were estimated using HUI (n = 33, EQ-5D (n = 26, TTO (n = 12, and SG (n = 14, with some studies applying more than one technique to estimate utility values. 21% of studies evaluated utilities in children, of those the majority being in the area of oncology. No utility values for children were reported in skin

  19. Characteristics of Adults with Down Syndrome: prevalence of age-related conditions

    Directory of Open Access Journals (Sweden)

    Angelo eCarfì

    2014-12-01

    Full Text Available Introduction. In the last decades, life expectancy of persons with Down syndrome (DS has dramatically increased and it is estimated that they will be living as long as the general population within a generation. Despite being included among the progeroid syndromes, because of the presence of features typically observed in older adults, DS is still regarded as a disease of pediatric interest. Because limited knowledge is available on the clinical characteristics of adults with DS, this study aimed to assess clinical and non-clinical features of this population and to describe similarities to the geriatric population. Methods. In this study, we described 60 adults with DS evaluated at the Day Hospital of the Geriatric Department of the Policlinico A. Gemelli, Università Cattolica del Sacro Cuore in Rome. Individuals were assessed through a standardized protocol. Results. The mean age of study participants was 38 years (range, 18 to 58 years and 42 (70.0% were women. Geriatric conditions were highly prevalent: severe cognitive impairment was diagnosed in 39 (65.0% participants, behavioral symptoms were present in 25 (41.7% and functional impairment in 23 (38.3%. Six (10.0% participants lived in institutions and 11 (18.3% were diagnosed as obese. The mean number of drugs used was 2.4; use of psychotropic drugs was highly prevalent. The most common chronic diseases were thyroid problems (44, 73.3%, followed by mood disorders (19, 31.7%, osteoporosis (18, 30.0% and cardiac problems (10, 16.7%. Geriatric conditions and chronic diseases were more prevalent among participants aged ≥40 years. Conclusions. Several similarities between older adults and adults with DS were observed. Comorbidities, geriatric conditions, cognitive and functional deficits and social problems are highly prevalent in both populations, contributing to the high complexity of these patients’ assessment and treatment.

  20. Load release balance test under unstable conditions effectively discriminates between physically active and sedentary young adults.

    Science.gov (United States)

    Zemková, E; Štefániková, G; Muyor, J M

    2016-08-01

    This study investigates test-retest reliability and diagnostic accuracy of the load release balance test under four varied conditions. Young, early and late middle-aged physically active and sedentary subjects performed the test over 2 testing sessions spaced 1week apart while standing on either (1) a stable or (2) an unstable surface with (3) eyes open (EO) and (4) eyes closed (EC), respectively. Results identified that test-retest reliability of parameters of the load release balance test was good to excellent, with high values of ICC (0.78-0.92) and low SEM (7.1%-10.7%). The peak and the time to peak posterior center of pressure (CoP) displacement were significantly lower in physically active as compared to sedentary young adults (21.6% and 21.0%) and early middle-aged adults (22.0% and 20.9%) while standing on a foam surface with EO, and in late middle-aged adults on both unstable (25.6% and 24.5%) and stable support surfaces with EO (20.4% and 20.0%). The area under the ROC curve >0.80 for these variables indicates good discriminatory accuracy. Thus, these variables of the load release balance test measured under unstable conditions have the ability to differentiate between groups of physically active and sedentary adults as early as from 19years of age. PMID:27203382

  1. Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging.

    Directory of Open Access Journals (Sweden)

    Elias Georges Gebara

    2013-08-01

    Full Text Available Adult hippocampal neurogenesis results in the formation of new neurons and is a process of brain plasticity involved in learning and memory. The proliferation of adult neural stem or progenitor cells is regulated by several extrinsic factors such as experience, disease or aging and intrinsic factors originating from the neurogenic niche. Microglia is very abundant in the dentate gyrus and increasing evidence indicates that these cells mediate the inflammation-induced reduction in neurogenesis. However, the role of microglia in neurogenesis in physiological conditions remains poorly understood. In this study, we monitored microglia and the proliferation of adult hippocampal stem/progenitor cells in physiological conditions known to increase or decrease adult neurogenesis, voluntary running and aging respectively. We found that the number of microglia in the dentate gyrus was strongly inversely correlated with the number of stem/progenitor cells and cell proliferation in the granule cell layer. Accordingly, co-cultures of decreasing neural progenitor/glia ratio showed that microglia but not astroglia reduced the number of progenitor cells. Together, these results suggest that microglia inhibits the proliferation of neural stem/progenitor cells despite the absence of inflammatory stimulus.

  2. Effects of different drying conditions on the rehydration ratio and water holding capacity properties in three different species of algae Ulva lactuca, Codium vermilara and Codium tomentosum

    OpenAIRE

    Rodrigues, Sidónio; Afonso, Clélia; Mouga, Teresa; Nunes, Paulo

    2014-01-01

    Over the last years, algae have been increasingly used in Human food due their rich chemical and nutritional composition, particularly the high supply of essential nutrients to the human body such as protein and dietary fiber. Dietary fiber can be divided into two different types: soluble and insoluble. The characteristics of soluble dietary fiber are related to some physical and chemical properties such as rehydration ratio and water holding capacity and are important in assigning t...

  3. A Behavioral Comparison of Male and Female Adults with High Functioning Autism Spectrum Conditions

    OpenAIRE

    Meng-Chuan Lai; Lombardo, Michael V.; Greg Pasco; Ruigrok, Amber N V; Wheelwright, Sally J.; Sadek, Susan A; Bhismadev Chakrabarti; Simon Baron-Cohen

    2011-01-01

    Autism spectrum conditions (ASC) affect more males than females in the general population. However, within ASC it is unclear if there are phenotypic sex differences. Testing for similarities and differences between the sexes is important not only for clinical assessment but also has implications for theories of typical sex differences and of autism. Using cognitive and behavioral measures, we investigated similarities and differences between the sexes in age- and IQ-matched adults with ASC (h...

  4. Reducing Recidivism and Symptoms in Emerging Adults with Serious Mental Health Conditions and Justice System Involvement

    OpenAIRE

    Davis, Maryann; Sheidow, Ashli J.; McCart, Michael R.

    2015-01-01

    The peak years of offending in the general population and among those with serious mental health conditions (SMHC) are during emerging adulthood. There currently are no evidence-based interventions for reducing offending behavior among 18–21 year olds, with or without SMHC. This open trial examined outcomes from an adaptation of Multisystemic Therapy (MST), an effective juvenile recidivism reduction intervention, modified for use with emerging adults with SMHC and recent justic...

  5. Factors Influencing Adult Physical Health after Controlling for Current Health Conditions: Evidence from a British Cohort

    OpenAIRE

    Cheng, Helen; Furnham, Adrian

    2013-01-01

    This study explored a longitudinal data set of 6875 British adults examining the effects of parental social status (measured at birth), cognitive ability (at age 11 yrs), personality traits, education and occupational attainment on physical health and functioning (all measured at age 50 yrs), after taking account of current health conditions (number of illness). Correlation analysis showed that parental social class, childhood cognitive ability, education and occupation, and two personality t...

  6. Original article Future perspectives as a condition of positive adaptation of young adults after traumatic experience

    OpenAIRE

    Marzanna Farnicka

    2014-01-01

    Background The paper presents the results of a study on the possible role of sense of influencing one’s life and expectations towards the future as a personal condition of adaptation. In accordance with the theory of formulation of temporal perspectives, these variables were assumed to be related to construction of the psychological reality of the subjects. Participants and procedure The study involved 162 adults in two groups, with traumatic experience and without such e...

  7. Thermal conditions during juvenile development affect adult dispersal in a spider

    OpenAIRE

    Bonte, Dries; Travis, Justin M. J.; Clercq, Nele De; Zwertvaegher, Ingrid; Lens, Luc

    2008-01-01

    Abstract: Understanding the causes and consequences of dispersal is a prerequisite for the effective management of natural populations. Rather than treating dispersal as a fixed trait, it should be considered a plastic process that responds to both genetic and environmental conditions. Here, we consider how the ambient temperature experienced by juvenile Erigone atra, a spider inhabiting crop habitat, influences adult dispersal. This species exhibits 2 distinct forms of dispersal, ballooning ...

  8. A review of health utilities across conditions common in paediatric and adult populations

    OpenAIRE

    Hopkins Robert B; Bischof Matthias; Burke Natasha; Tarride Jean-Eric; Goeree Linda; Campbell Kaitryn; Xie Feng; O'Reilly Daria; Goeree Ron

    2010-01-01

    Abstract Background Cost-utility analyses are commonly used in economic evaluations of interventions or conditions that have an impact on health-related quality of life. However, evaluating utilities in children presents several challenges since young children may not have the cognitive ability to complete measurement tasks and thus utility values must be estimated by proxy assessors. Another solution is to use utilities derived from an adult population. To better inform the future conduct of...

  9. Relationship between Anthropometric Factors, Gender, and Balance under Unstable Conditions in Young Adults

    OpenAIRE

    Júlia Maria D’Andréa Greve; Mutlu Cuğ; Deniz Dülgeroğlu; Guilherme Carlos Brech; Angelica Castilho Alonso

    2013-01-01

    The objective of this study was to evaluate the relationship between the anthropometric factors of height, body mass, body mass index and postural balance and to compare the balance indices between genders in the upright standing position, in healthy adult subjects under conditions of instability. Forty individuals were subjected to functional tests of body stability using the Biodex Balance System, and the resulting indices were correlated with body mass, height, and body mass index, and als...

  10. Thermal conditions during juvenile development affect adult dispersal in a spider.

    Science.gov (United States)

    Bonte, Dries; Travis, Justin M J; De Clercq, Nele; Zwertvaegher, Ingrid; Lens, Luc

    2008-11-01

    Understanding the causes and consequences of dispersal is a prerequisite for the effective management of natural populations. Rather than treating dispersal as a fixed trait, it should be considered a plastic process that responds to both genetic and environmental conditions. Here, we consider how the ambient temperature experienced by juvenile Erigone atra, a spider inhabiting crop habitat, influences adult dispersal. This species exhibits 2 distinct forms of dispersal, ballooning (long distance) and rappelling (short distance). Using a half-sib design we raised individuals under 4 different temperature regimes and quantified the spiders' propensity to balloon and to rappel. Additionally, as an indicator of investment in settlement, we determined the size of the webs build by the spiders following dispersal. The optimal temperature regimes for reproduction and overall dispersal investment were 20 degrees C and 25 degrees C. Propensity to perform short-distance movements was lowest at 15 degrees C, whereas for long-distance dispersal it was lowest at 30 degrees C. Plasticity in dispersal was in the direction predicted on the basis of the risks associated with seasonal changes in habitat availability; long-distance ballooning occurred more frequently under cooler, spring-like conditions and short-distance rappelling under warmer, summer-like conditions. Based on these findings, we conclude that thermal conditions during development provide juvenile spiders with information about the environmental conditions they are likely to encounter as adults and that this information influences the spider's dispersal strategy. Climate change may result in suboptimal adult dispersal behavior, with potentially deleterious population level consequences. PMID:18974219

  11. Relationship between continuity of care and adverse outcomes varies by number of chronic conditions among older adults with diabetes

    OpenAIRE

    DuGoff, Eva H.; Bandeen-Roche, Karen; Anderson, Gerard F.

    2016-01-01

    Background: Continuity of care is a basic tenant of primary care practice. However, the evidence on the importance of continuity of care for older adults with complex conditions is mixed. Objective: To assess the relationship between measurement of continuity of care, number of chronic conditions, and health outcomes. Design: We analyzed data from a cohort of 1,600 US older adults with diabetes and ≥1 other chronic condition in a private Medicare health plan from July 2010 to December 2011. M...

  12. The Effects of Carcass Conditioning on Shear Force Values and Water Holding Capacity of Different Skeletal Muscles of Malaysian Indigenous (MALIN Sheep and the Changes in Their pH and Glycogen Contents

    Directory of Open Access Journals (Sweden)

    Panandam Jothi Malar

    2011-01-01

    Full Text Available This study investigated the effects of carcass conditioning on shear force values and water holding capacity of various major skeletal muscles (Infraspinatus, Supraspinatus, Triceps brachii, Longissimus dorsi, Rectus femoris, Vastus lateralis, Semitendinosus, Semimembranosus and Adductor femoris obtained from a total of 18, 1 year old Malaysian Indigenous rams. It also studied the effect of conditioning on changes in their pH and glycogen contents. Sequel to the conditioning, muscle samples were analysed for shear force values and water holding capacity. The postmortem conditioning resulted in significant decline (p>0.05 in muscle pH, glycogen, shear force values and drip loss while the cooking loss remained unaffected. Statistically, there was no interaction (p>0.05 between the conditioning period and muscle type and this indicates that the effects of conditioning on muscle pH, shear force values, drip loss and cooking loss were independent of the muscle type. Meanwhile, its effect on glycogen was influenced by the muscle type.

  13. Measuring health-related quality of life in adults with chronic conditions in primary care settings

    Science.gov (United States)

    Hand, Carri

    2016-01-01

    Abstract Objective To describe health-related quality of life (HRQOL) conceptual frameworks, critically review 3 commonly used HRQOL scales relevant to adults with chronic conditions in primary care settings, and make recommendations for using HRQOL scales in primary care practice. Data sources Information was accessed regarding HRQOL conceptual and theoretical approaches. A comprehensive search strategy identified 3 commonly used scales that met the review criteria and evidence regarding use of the scales in adults with chronic conditions in community settings. Scale selection Scales were selected if they were designed for clinical use; were easy to administer; were generic and broad in content areas; and contained some individualized items. Scales were critiqued according to content development, theoretical basis, psychometric properties, scoring, feasibility, the concepts being measured, and the number of items that measured an individualized concept. Synthesis Early HRQOL approaches focused on health and functional status while recent approaches incorporate individualized concepts such as the person’s own values and the environment. The abbreviated World Health Organization Quality of Life Scale (WHOQOL-BREF), the 36-Item Short Form Health Survey (SF-36), and the Duke Health Profile were critiqued. All address physical, mental, and social domains, while the WHOQOL-BREF also addresses environment. Psychometric evidence supports use of the SF-36 and WHOQOL-BREF with this population. The SF-36 has the most evidence of responsiveness but has some floor and ceiling effects, while the WHOQOL-BREF does not appear to have floor or ceiling effects but has limited evidence of responsiveness. The WHOQOL-BREF has the highest proportion of individualized items. Conclusion Measurement of HRQOL in adults with chronic conditions can support patient management and contribute to primary care service evaluation. Scales that are based on a broad definition of health and that

  14. Reducing recidivism and symptoms in emerging adults with serious mental health conditions and justice system involvement.

    Science.gov (United States)

    Davis, Maryann; Sheidow, Ashli J; McCart, Michael R

    2015-04-01

    The peak years of offending in the general population and among those with serious mental health conditions (SMHC) are during emerging adulthood. There currently are no evidence-based interventions for reducing offending behavior among 18-21 year olds, with or without SMHC. This open trial examined outcomes from an adaptation of Multisystemic Therapy (MST), an effective juvenile recidivism reduction intervention, modified for use with emerging adults with SMHC and recent justice system involvement. MST for emerging adults (MST-EA) targets MH symptoms, recidivism, problem substance use, and young adult functional capacities. All study participants (n = 41) were aged 17-20 and had a MH diagnosis and recent arrest or incarceration. Implementation outcomes indicated that MST-EA was delivered with strong fidelity, client satisfaction was high, and the majority of participants successfully completed the intervention. Research retention rates also were high. Pre-post-analyses revealed significant reductions in participants' MH symptoms, justice system involvement, and associations with antisocial peers. PMID:25023764

  15. Biomechanics in young and adult italian standardbred trotter horses in real racing conditions.

    Science.gov (United States)

    Vilar, J M; Spadari, A; Billi, V; Desini, V; Santana, A

    2008-06-01

    This study was undertaken to characterize and establish the kinematic standards of Italian standardbred trotter horses in real racing conditions. Certain parameters, such as the angles of both front and hind fetlock joints, stride length, stride frequency and average speed in youngs and adults are presented, examinated and compared with statistical tests. The angles and stride length were obtained using ONTRACK software over frames extracted from two CANON MV630i digital videocameras. For the stride frequency, a third identical videocamera filmed the horses to count the number of beats per minute. The average speed was calculated by multiplying the stride frequency by the stride length and transforming the result into kilometers per hour. The data reveal that as speed increases, younger horses have more extended fetlock joints than adults. Contrary to this, at the maximum speed (hereafter referred to as sprint speed) the adults increase both their stride frequency and stride length, while young horses increase stride frequency and decrease stride length. We think that the knowledge of these parameters in competition breeds could have potential relevance as they may reveal early indicators of the development of proper and adequate characteristics in young horses of those breeds. PMID:18431685

  16. Co-Occurrence of Leading Lifestyle-Related Chronic Conditions Among Adults in the United States, 2002-2009

    OpenAIRE

    Ford, Earl S.; Croft, Janet B.; Posner, Samuel F.; Goodman, Richard A.; Giles, Wayne H.

    2013-01-01

    Introduction Public health and clinical strategies for meeting the emerging challenges of multiple chronic conditions must address the high prevalence of lifestyle-related causes. Our objective was to assess prevalence and trends in the chronic conditions that are leading causes of disease and death among adults in the United States that are amenable to preventive lifestyle interventions. Methods We used self-reported data from 196,240 adults aged 25 years or older who participated in the Nat...

  17. Associations between U.S. Adult Obesity and State and County Economic Conditions in the Recession

    Directory of Open Access Journals (Sweden)

    Qi Zhang

    2014-01-01

    Full Text Available This study examines the association between state and county unemployment rates and individuals’ body weight status during the latest recession in the U.S. We used the U.S. Behavioral Risk Factor Surveillance System (BRFSS data in 2007, 2009 and 2011, which were collected from 722,692 American adults aged 18 or older. Overweight and obesity were defined as body mass index (BMI ≥25, and ≥30, respectively. Multivariate linear and logistic regressions were applied to assess the association between BMI, risks of overweight and obesity, and state and county unemployment rates. State unemployment rates were negatively associated with individual BMI across years, while county unemployment rates were significantly positively associated with BMI and obesity rates in all years (p < 0.05. However, the scale of the positive relationship was reduced in 2009 and 2011. Stratified analyses were conducted among adults with employment and without employment. The unemployed group’s body weight status was not related to state- and county-level economic conditions in most times. In the pooled analyses with all three years’ data, the relationship between unemployment rates and body weight status were consistently reduced after the recession of 2008–2009. Our results indicated that macroeconomic conditions at different levels can have different associations with individuals’ obesity risk across time.

  18. Jianglong Holding Restructured

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    After seven months’shut-down,Guangfeng Dyeing&Printing Co.,Ltd.started operation on May 18th,in situconversion of Zhejiang Jianglong Dyeing&Printing HoldingCo.,Ltd.This marks the successful restructure of JianglongHolding.Jianglong was a vertical enterprise invloving in dyeing/printing,textile/garment manufactunng and trade.On Oct.

  19. Effects of heavy metal exposure on the condition and health of adult great tits (Parus major)

    International Nuclear Information System (INIS)

    We examined the possible effects of heavy metal exposure on the quality and health of adult great tits (Parus major) at four study sites along a pollution gradient near a non-ferrous smelter in Belgium. Tarsus length, wing length, body mass and condition of great tits were compared with respect to study site, age (first-year and older great tits), sex and season (birds caught in winter and during breeding). Tarsus length did not differ significantly among study sites. The wing length of great tits was larger at the study site furthest from the smelter, especially for older great tits. The length of the outermost tail feathers, however, did not differ significantly among study sites. We found no signs of loss of body mass or condition towards the pollution source. The body mass and condition was lowest for female great tits at the site furthest from the smelter, especially during winter. Haematocrit values did not differ significantly among sites. Overall, we found no clear significant effects of heavy metal pollution on morphological measurements and health parameters of great tits. - Heavy metal pollution had no clear effect on condition and health, but this may have been masked by habitat quality differences and gene flow

  20. A behavioral comparison of male and female adults with high functioning autism spectrum conditions.

    Directory of Open Access Journals (Sweden)

    Meng-Chuan Lai

    Full Text Available Autism spectrum conditions (ASC affect more males than females in the general population. However, within ASC it is unclear if there are phenotypic sex differences. Testing for similarities and differences between the sexes is important not only for clinical assessment but also has implications for theories of typical sex differences and of autism. Using cognitive and behavioral measures, we investigated similarities and differences between the sexes in age- and IQ-matched adults with ASC (high-functioning autism or Asperger syndrome. Of the 83 (45 males and 38 females participants, 62 (33 males and 29 females met Autism Diagnostic Interview-Revised (ADI-R cut-off criteria for autism in childhood and were included in all subsequent analyses. The severity of childhood core autism symptoms did not differ between the sexes. Males and females also did not differ in self-reported empathy, systemizing, anxiety, depression, and obsessive-compulsive traits/symptoms or mentalizing performance. However, adult females with ASC showed more lifetime sensory symptoms (p = 0.036, fewer current socio-communication difficulties (p = 0.001, and more self-reported autistic traits (p = 0.012 than males. In addition, females with ASC who also had developmental language delay had lower current performance IQ than those without developmental language delay (p<0.001, a pattern not seen in males. The absence of typical sex differences in empathizing-systemizing profiles within the autism spectrum confirms a prediction from the extreme male brain theory. Behavioral sex differences within ASC may also reflect different developmental mechanisms between males and females with ASC. We discuss the importance of the superficially better socio-communication ability in adult females with ASC in terms of why females with ASC may more often go under-recognized, and receive their diagnosis later, than males.

  1. Preformed stainless steel crown in special conditions in adults: Two case reports

    Directory of Open Access Journals (Sweden)

    S Madhu

    2015-01-01

    Full Text Available Stainless steel crowns (SSC are extensively used in child patients. They are mainly used following the pulp therapy in deciduous teeth. They are also used in multi-surface restoration, as an abutment in space maintainers, correction of anterior tooth cross bite, restoration of hypoplasic teeth, etc. In permanent teeth, they are mainly used as interim restorations following root canal treatment in first molars prior to the eruption of permanent second molars. The main advantage of SSC is its limited chair side time, durability and ease of placement. Patients with conditions such as pregnancy and old age who cannot tolerate multiple and long appointments can greatly benefit from the use of SSC. Though SSC can be used by other dental specialties very effectively, its use seems to be limited to pediatric dentistry. Presented here are few adult cases in which SSC is given with good success.

  2. Obesity and Malnutrition: Impact of Habitat and Living Conditions in Adult Urban Population in Argentina

    Directory of Open Access Journals (Sweden)

    Karina Temporelli

    2015-05-01

    Full Text Available Introduction: malnutrition refers to imbalances (either deficit or excess in energy intake, protein and / or nutrients including underweight and obesity. The aim of this work is identify the contribution of individual factors, habits and life conditions in nutritional status. Material and methods: estimates of relative risk ratios are obtained from a multinomial logistic model using microdata from the National Survey of Risk Factors conducted in 2005 and 2009 in Argentinean‘ cities among adult population. Results: malnutrition is associated with constitutive and socioeconomic variables, while habits are also important in the obesity case. Discussion: both types of problems coexist in Argentine due to high heterogeneity in life styles, turning difficult the design of public interventions aimed to solve them. This complexity highlights the importance of a careful and specific multidimensional approach (medical, social, economical.

  3. A Comparison of the Visual Attention Patterns of People with Aphasia and Adults without Neurological Conditions for Camera-Engaged and Task-Engaged Visual Scenes

    Science.gov (United States)

    Thiessen, Amber; Beukelman, David; Hux, Karen; Longenecker, Maria

    2016-01-01

    Purpose: The purpose of the study was to compare the visual attention patterns of adults with aphasia and adults without neurological conditions when viewing visual scenes with 2 types of engagement. Method: Eye-tracking technology was used to measure the visual attention patterns of 10 adults with aphasia and 10 adults without neurological…

  4. Psychological Stressors and Burden of Medical Conditions in Older Adults: A Psychosomatic Approach

    Directory of Open Access Journals (Sweden)

    Arash Mani

    2009-12-01

    Full Text Available "n  "n  "nObjective: "nIn geriatric practice, the impact of psychological distress on health status has been undermined due to ageism, atypical presentation and less tendency to report negative affect among elderly people. Few studies have examined the impact of psychological stressors on medical burden in older adults. The current study has investigated the correlation of psychological distress and burden of medical conditions in a sample of older people .     "n  "n  "nMethod: A convenient study sample of 120 elderly subjects was recruited from the places where there was greater chance for the elderly people to attend. Data were collected by a trained research assistant using perceived stress scale, cumulative illness rating scale, geriatric depressive scale and a demographic questionnaire.     "n  "n  "nResults: "nOur participants perceived more level of stress than the average for their age. In the current study, the burden of medical condition was significantly correlated with the level of perceived stress(r = .197, p = .044. Moreover, in regression analysis, perceived stress was the strongest predictor for physical health morbidity (R2 =.049, significant f= .03.     "n  "n  "nConclusions: "nThe result of this study suggested that the psychological stressors contribute to poor health outcome in older adults ; the area that is usually overlooked due to ageism and its physiological related changes. The medical practitioners should consider the psychological distress as a part of etiological factors implicating in health morbidity among their aged patients.

  5. Holding Costs and Equilibrium Arbitrage

    OpenAIRE

    Tuckman, Bruce; Vila, Jean-Luc.

    1993-01-01

    This paper constructs a dynamic model of the equilibrium determination of relative prices when arbitragers face holding costs. The major findings are that 1) models based on riskless arbitrage arguments alone may not provide usefully tight bounds on observed prices, 2) arbitragers are often most effective in eliminating the mispricings of shorter-term assets, 3) arbitrage activity increases the mean reversion of changes in the mispricing process and reduces their conditional volatility, and 4...

  6. Social conditions and urban environment associated with participation in the Ciclovia program among adults from Cali, Colombia

    OpenAIRE

    Luis Fernando Gómez; Janeth Mosquera; Olga Lucia Gómez; José Moreno; Jose D. Pinzon; Enrique Jacoby; Magda Cepeda; Diana Celmira Parra

    2015-01-01

    Abstract The Ciclovia program (CP) has emerged as an effective initiative to promote active living in urban spaces in Latin America. This study assessed the association between social conditions, the urban environment and participation in the CP among adults living in the city of Cali, Colombia. A cross-sectional study was conducted in 2011 and 2012 among 719 adults aged 18 to 44. Urban environment measures were obtained using Geographic Information Systems. A multilevel logistic regression w...

  7. Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction

    OpenAIRE

    Korf-Klingebiel, Mortimer; Kempf, Tibor; Schlüter, Klaus-Dieter; Willenbockel, Christian; Brod, Torben; Heineke, Jörg; Volker J Schmidt; Jantzen, Franziska; Ralf P Brandes; Sugden, Peter H.; Drexler, Helmut; Molkentin, Jeffery D.; Wollert, Kai C.

    2011-01-01

    BACKGROUND: Fibroblast growth factor 9 (FGF9) is secreted from bone marrow cells, which have been shown to improve systolic function after myocardial infarction (MI) in a clinical trial. FGF9 promotes cardiac vascularization during embryonic development but is only weakly expressed in the adult heart. METHODS AND RESULTS: We used a tetracycline-responsive binary transgene system based on the α-myosin heavy chain promoter to test whether conditional expression of FGF9 in the adult myocardiu...

  8. Periodontal conditions and associated factors among adults and the elderly: findings from the first National Oral Health Survey in Uruguay

    OpenAIRE

    Susana M. Lorenzo; Ramón Alvarez; Ernesto Andrade; Virginia Piccardo; Alejandro Francia; Fernando Massa; Marcos Britto Correa; Marco Aurélio Peres

    2015-01-01

    Abstract The aims of this study were to assess the prevalence of periodontal conditions in the Uruguayan adult and elderly population and its association with socioeconomic and behavioral characteristics. Data from adults (35-44, n = 358) and elderly (65-74, n = 411) who participated in the first National Oral Health Survey, Uruguay, 2011, were used. The survey included a household questionnaire addressing socioeconomic characteristics, and tobacco use. Bleeding on probing (BOP), periodontal ...

  9. Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes

    OpenAIRE

    Pastos, Karen M.; Slayton, William B.; Rimsza, Lisa M.; Young, Linda; Sola-Visner, Martha C.

    2006-01-01

    Umbilical cord blood (CB) is a valuable source of stem cells for transplantation, but CB transplantations are frequently complicated by delayed platelet engraftment. The reasons underlying this are unclear. We hypothesized that CB- and peripheral-blood (PB)–derived megakaryocytes (MKs) respond differently to the adult hematopoietic microenvironment and to thrombopoietin (Tpo). To test this, we cultured CB- and PB-CD34+ cells in adult bone marrow stromal conditioned media (CM) or unconditioned...

  10. Original article Future perspectives as a condition of positive adaptation of young adults after traumatic experience

    Directory of Open Access Journals (Sweden)

    Marzanna Farnicka

    2014-10-01

    Full Text Available Background The paper presents the results of a study on the possible role of sense of influencing one’s life and expectations towards the future as a personal condition of adaptation. In accordance with the theory of formulation of temporal perspectives, these variables were assumed to be related to construction of the psychological reality of the subjects. Participants and procedure The study involved 162 adults in two groups, with traumatic experience and without such experience, aged 18-35. The tools used in the study included: Rosenberg Self-Esteem Scale (SES, Boszkiewicz Questionnaire: Life Experience Questionnaire, events evaluation and expectations of changes in the future. Results The study revealed significant differences between people from the two groups in the scope of self-evaluation, sense of influence on events and future expectations. Conclusions The results pointed to the need for adjustment of therapeutic and preventive treatment to future expectations, evaluation of events and the current stage of development, as indicated by personal conditions of adaptation.

  11. Conditioned fear in adult rats is facilitated by the prior acquisition of a classically conditioned motor response

    OpenAIRE

    Lindquist, Derick H.; Mahoney, Luke P.; Steinmetz, Joseph E.

    2010-01-01

    Early in eyeblink classical conditioning, amygdala-dependent fear responding is reported to facilitate acquisition of the cerebellar-dependent eyeblink conditioned response (CR), in accord with the two-process model of conditioning (Konorski, 1967). In the current study, we predicted that the conditioned fear (e.g., freezing) observed during eyeblink conditioning may become autonomous of the eyeblink CR and amenable to further associative modification. Conditioned freezing was assessed during...

  12. National Survey of Oral/Dental Conditions Related to Tobacco and Alcohol Use in Mexican Adults

    Directory of Open Access Journals (Sweden)

    Carlo Eduardo Medina-Solís

    2014-03-01

    Full Text Available Oral diseases are a major burden on individuals and health systems. The aim of this study was to determine whether consumption of tobacco and alcohol were associated with the prevalence of oral/dental problems in Mexican adults. Using data from the National Performance Evaluation Survey 2003, a cross-sectional study part of the World Health Survey, dental information from a representative sample of Mexico (n = 22,229, N = 51,155,740 was used to document self-reported oral/dental problems in the 12 months prior to the survey. Questionnaires were used to collect information related to sociodemographic, socioeconomic, and other risk factors. Three models were generated for each age group (18–30, 31–45 and 46–98 years. The prevalence of oral/dental conditions was 25.7%. Adjusting for sex, schooling, socioeconomic position, diabetes, and self-reported health, those who used tobacco (sometimes or daily (OR = 1.15, p = 0.070; OR = 1.24, p < 0.01; and OR = 1.16, p < 0.05, for each age group respectively or alcohol (moderate or high (OR = 1.26, p < 0.001; OR = 1.18, p < 0.01 and OR = 1.30, p < 0.001, for each age group respectively had a higher risk of reporting oral/dental problems. Because tobacco and alcohol use were associated with self-reported oral/dental problems in one out of four adults, it appears advisable to ascertain how direct is such link; more direct effects would lend greater weight to adopting measures to reduce consumption of tobacco and alcohol for the specific purpose of improving oral health.

  13. Importance of lunar and temporal conditions for spotlight surveys of adult black-footed ferrets

    Science.gov (United States)

    Eads, David A.; Jachowski, David S.; Millspaugh, Joshua J.; Biggins, Dean E.

    2012-01-01

    Black-footed ferrets (Mustela nigripes) spend most daylight hours underground in prairie dog (Cynomys) burrows and exhibit aboveground movements primarily at night. Moonlight can influence the activity patterns of ferrets and, consequently, might influence the efficiency of spotlight surveys used by biologists to monitor ferret populations. We related detection of adult ferrets during postbreeding spotlight surveys to lunar and temporal conditions. We most frequently located ferrets during surveys in which the moon breached the horizon. The data suggested intersexual differences in response to moonlight. We located male ferrets most frequently during nights with greater moon illumination, but we did not detect a correlation between moon illumination and spotlight detection of female ferrets. In general, moonlight could facilitate aboveground navigation by ferrets. However, it seems activity under bright moonlight could be costly for female ferrets while they raise young. Detection of ferrets also varied among months. We detected female ferrets most frequently in August–September, when mothers increase hunting efforts to acquire prey for growing offspring (kits). Detection of adult female ferrets declined in October, when kits were likely independent of their mother. We located male ferrets most frequently in September–October, when males might increase activity to monitor female ferrets and male competitors. Consideration of lunar and temporal influences and standardization of postbreeding surveys could enhance site-specific assessment of reintroduction success and across-site assessment of species recoveiy progress. We suggest that postbreeding surveys for ferrets should be enhanced by concentrating efforts in August–September during moonlit nights when the moon is above the horizon.

  14. Effects of Mirazid® and myrrh volatile oil on adult Fasciola gigantica under laboratory conditions

    Institute of Scientific and Technical Information of China (English)

    AM Massoud; HA Shalaby; RM El Khateeb; MS Mahmoud; MA Kutkat

    2012-01-01

    Objective: To evaluate the effects of Mirazid® and myrrh volatile oil on adult Fasciola gigantica (F. gigantica ) under laboratory conditions. Methods: The effects of oleoresin extract of myrrh (Mirazid®) and myrrh volatile oil on the surface morphology of adult F. gigantica following treatment in vitro had been determined by scanning electron microscopy. The results were compared with those observed in the fluke tegument following incubation in triclabendazole sulphoxide (TCBZ-SO), active form, (Fasinex®, Ciba-Geigy). Results: Observations of the efficacy of Mirazid® oleoresin extract and myrrh volatile oil indicated that both products showed dose-dependent anthelmintic efficacy. The anterior half of the fluke was consistently more severely affected than the posterior half. The surface changes induced by Mirazid® oleoresin extract were less severe than those observed after exposure to either myrrh volatile oil or TCBZ-SO. Flukes showed swelling after these treatments, but its level and blebbing were much greater with myrrh volatile oil; in which patches of tegumental sloughing were observed in the apical cone and the posterior mid-body region of flukes. This was not observed after treatment with Mirazid® oleoresin extract. Conclusions: The comparatively more disruption, observed in myrrh volatile oil exposed specimens, compared to that exposed to Mirazid® oleoresin extract might suggest that the anthelmintic activity of Mirazid® oleo resin extract was attributed to its content of volatile oil. So, increasing the concentration of myrrh volatile oil in Mirazid® might possibly help to developing its anthelmintic activity.

  15. Adult Strabismus

    Science.gov (United States)

    ... Conditions Frequently Asked Questions Español Condiciones Chinese Conditions Adult Strabismus En Español Read in Chinese Can anything be done for adults with strabismus (misaligned eyes)? Yes. Adults can benefit ...

  16. Hydraulic fuel hold down

    International Nuclear Information System (INIS)

    A method of holding down fuel assemblies in pressurized water reactors is described which minimizes flow restrictions, compensates for variations in primary coolant flow, and provides a steam release path through the reactor in the event of a loss of coolant accident. A pressure vessel is divided by a seal plate structure into a high-pressure and a low-pressure plenum. A piston in sliding relationship with the seal has push rods attached which hold down the fuel asemblies of the core. (LL)

  17. Conditional, genetic disruption of ciliary neurotrophic factor receptors reveals a role in adult motor neuron survival

    OpenAIRE

    Lee, Nancy; Robitz, Rachel; Zurbrugg, Rebekah J; Karpman, Adam M; Mahler, Ashley M.; Cronier, Samantha A.; Vesey, Rachel; Spearry, Rachel P.; Zolotukhin, Sergei; MacLennan, A. John

    2008-01-01

    Indirect evidence suggests that endogenous ciliary neurotrophic factor (CNTF) receptor signaling can promote motor neuron (MN) survival in the adult. If so, proper targeting of this signaling may selectively counteract the effects of adult MN diseases. However, direct evidence for CNTF receptor involvement in adult MN survival is lacking, presumably because the unconditional blockade of the mouse CNTF receptor in vivo [through genetic disruption of the essential CNTF receptor α (CNTFRα) gene]...

  18. The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice.

    Directory of Open Access Journals (Sweden)

    Valérie Manceau

    Full Text Available The brain-enriched protein kinase KIS (product of the gene UHMK1 has been shown to phosphorylate the human splicing factor SF1 in vitro. This phosphorylation in turn favors the formation of a U2AF(65-SF1-RNA complex which occurs at the 3' end of introns at an early stage of spliceosome assembly. Here, we analyzed the effects of KIS knockout on mouse SF1 phosphorylation, physiology, adult behavior, and gene expression in the neonate brain. We found SF1 isoforms are differently expressed in KIS-ko mouse brains and fibroblasts. Re-expression of KIS in fibroblasts restores a wild type distribution of SF1 isoforms, confirming the link between KIS and SF1. Microarray analysis of transcripts in the neonate brain revealed a subtle down-regulation of brain specific genes including cys-loop ligand-gated ion channels and metabolic enzymes. Q-PCR analyses confirmed these defects and point to an increase of pre-mRNA over mRNA ratios, likely due to changes in splicing efficiency. While performing similarly in prepulse inhibition and most other behavioral tests, KIS-ko mice differ in spontaneous activity and contextual fear conditioning. This difference suggests that disregulation of gene expression due to KIS inactivation affects specific brain functions.

  19. Social resources and disordered living conditions: evidence from a national sample of community-residing older adults.

    Science.gov (United States)

    York Cornwell, Erin

    2014-07-01

    For older adults aging in the community, living conditions can promote health, enhance coping, and reduce disablement--but they can also create stress and increase risks of illness, accidents, and decline. Although socioeconomic disparities in housing likely contribute to inequalities in interior conditions, I argue that living conditions are also shaped by social resources such as coresidential relationships, social network ties, and social support. In this article, I examine the distribution of a set of risky or stressful physical and ambient living conditions including structural disrepair, clutter, lack of cleanliness, noise, and odor. Using data from the National Social Life, Health, and Aging Project (NSHAP), I find that low-income and African American older adults have more disordered living conditions as do those with poorer physical and mental health. In addition, older adults who have a coresident partner, more nonresidential network ties, and more sources of instrumental support are exposed to fewer risky or harmful living conditions. This suggests that living conditions are an important, though overlooked, mechanism through which household composition, social networks, and social support affect health and well-being in later life. PMID:25651314

  20. Treatment, risk factors, and outcome of adults with relapsed AML after reduced intensity conditioning for allogeneic stem cell transplantation

    DEFF Research Database (Denmark)

    Schmid, Christoph; Labopin, Myriam; Nagler, Arnon; Niederwieser, Dietger; Castagna, Luca; Tabrizi, Reza; Stadler, Michael; Kuball, Jürgen; Cornelissen, Jan; Vorlicek, Jiri; Socié, Gerard; Falda, Michele; Vindeløv, Lars; Ljungman, Per; Jackson, Graham; Kröger, Nicolaus; Rank, Andreas; Polge, Emmanuelle; Rocha, Vanderson; Mohty, Mohamad

    2012-01-01

    Since information on management and outcome of adults with AML relapsing after allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning (RIC HSCT) is scarce, a retrospective registry study was performed by the Acute Leukemia Working Party of EBMT. Among 2815 RIC...

  1. Genetic Conditions: A Resource Book and Instructional Guide to Human Heredity and Birth Defects for Kindergarten Through Adult Education.

    Science.gov (United States)

    California State Dept. of Education, Sacramento.

    Designed for administrators, teachers, school nurses, and others involved in health education for kindergarten through adult education, the resource guide provides curriculum ideas for instruction in genetic conditions, heredity, and birth defects. Student learning objectives, content information, learning activities, and evaluation methods are…

  2. Shenzhen Textile Holdings

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Shenzhen Textile(Holdings)Co.,Ltd,founded in 1994 on the basis of the state-owned Shenzhen Textile Industry Company,listed on Shenzhen Stock Exchange in name of"Shen Fangzhi A"and"Shen Fangzhi B"in August 1994,the Group is mainly engaged in manufacturing,as well

  3. Glucocorticoid receptor blockade in the posterior interpositus nucleus reverses maternal separation-induced deficits in adult eyeblink conditioning

    OpenAIRE

    Wilber, Aaron A.; Lin, Grant L.; Wellman, Cara L.

    2010-01-01

    Previously, we showed that neonatal maternal separation impaired eyeblink conditioning in adult rats. This impairment is correlated with increased glucocorticoid receptor (GR) expression in the cerebellar posterior interpositus nucleus, a critical site of learning-related plasticity. To assess whether increased GR expression is responsible for the separation-induced learning impairment, we infused a GR antagonist (mifepristone) or vehicle into the posterior interpositus during eyeblink condit...

  4. Overweight, obesity and related conditions: a cross-sectional study of adult inpatients at a Norwegian Hospital

    OpenAIRE

    Følling, Ingrid Sørdal; Kulseng, Bård; Helvik, Anne-Sofie

    2014-01-01

    Background Overweight, obesity and associated conditions are major public health concerns in Norway. The prevalence of overweight and obesity in the general population in Norway is increasing, but there are limited data on how the situation is in hospitals. This study aimed to find the prevalence of overweight and obesity, and explore the associations of overweight, obesity and its related medical conditions in an adult in-patient sample at specified somatic and psychiatric departments at St....

  5. Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviours

    Directory of Open Access Journals (Sweden)

    Lillian eGarrett

    2015-11-01

    Full Text Available Adult neurogenesis occurs in the adult mammalian subventricular zone (SVZ along the walls of the lateral ventricles and the subgranular zone (SGZ of the hippocampal dentate gyrus. While a burgeoning body of research implicates adult neurogenesis in olfactory bulb (OB - and hippocampal-related behaviors, the precise function continues to elude. To further assess the behavioral importance of adult neurogenesis, we herein generated a novel inducible transgenic mouse model of adult neurogenesis reduction where mice with CreERT2 under doublecortin (DCX promoter control were crossed with mice where diphtheria toxin A (DTA was driven by the Rosa26 promoter. Activation of DTA, through the administration of tamoxifen (TAM, results in a specific reduction of DCX+ immature neurons in both the hippocampal dentate gyrus and OB. We show that the decrease of DCX+ cells causes impaired social discrimination ability in both young adult (from 3 months and middle (from 10 months aged mice. Furthermore, these animals showed an age-independent altered coping behavior in the Forced Swim Test without clear changes in anxiety-related behavior. Notably, these behavior changes were reversible on repopulating the neurogenic zones with DCX+ cells on cessation of the tamoxifen treatment, demonstrating the specificity of this effect. Overall, these results support the notion that adult neurogenesis plays a role in social memory and in stress coping but not necessarily in anxiety-related behavior.

  6. Mesenteric vasculitis in adults with Henoch-Schonlein purpura: a not-so-benign condition.

    LENUS (Irish Health Repository)

    Sibartie, V

    2009-02-07

    INTRODUCTION: The gastrointestinal manifestations of Henoch-Schonlein purpura (HSP) are well characterised, but their recognition can be difficult when they occur in isolation. Furthermore, HSP can run a more serious course in adults, compared to children, in whom the disease usually occurs. MATERIALS AND METHODS: We describe two cases that illustrate the challenges of HSP with mesenteric vasculitis and the outcome in adults. CONCLUSION: Although self-limiting in most patients, the outcome of HSP in adults can be far from benign and even fatal.

  7. Differences in the definition of internal target volumes using slow CT alone or in combination with thin-slice CT under breath-holding conditions during the planning of stereotactic radiotherapy for lung cancer

    International Nuclear Information System (INIS)

    Purpose: To investigate how the delineations of the internal target volume (ITV) made from 'slow' CT alter with reference to 'thin-slice' CT. Materials and methods: Thin-slice CT images taken under breath-holding conditions and slow CT images taken under shallow-breathing conditions (8 s/image) of 11 lung cancers were used for this study. Five radiation oncologists delineated ITV of the 11 lesions using slow CT images (ITV1), and then redefined them with reference to thin-slice CT images (ITV2). SD-images (standard deviation image) were created for all patients from ITV images in order to visualize the regional variation of the ITVs. Results: The mean value of ITV2 was smaller than that initially defined by ITV1. There was no significant change in ITV1 and ITV2 between operators with regard to standard deviation in volume. There was a significant difference in the distribution of the ratio of ITV1 to ITV2 obtained on thin-slice CTs between cases with and without ground glass opacity. In cases without ground glass opacity there was a tendency for ITV2 to have a smaller volume than ITV1. Conclusions: Combined use of slow CT and thin-slice CT in delineation of ITV contours appeared to be useful in making adjustments for obscured tumor images caused by respiratory movement

  8. Peripheral Blood Monocytes as Adult Stem Cells: Molecular Characterization and Improvements in Culture Conditions to Enhance Stem Cell Features and Proliferative Potential

    OpenAIRE

    Hendrik Ungefroren; Ayman Hyder; Maren Schulze; Fawzy El-Sayed, Karim M.; Evelin Grage-Griebenow; Nussler, Andreas K.; Fred Fändrich

    2016-01-01

    Adult stem or programmable cells hold great promise in diseases in which damaged or nonfunctional cells need to be replaced. We have recently demonstrated that peripheral blood monocytes can be differentiated in vitro into cells resembling specialized cell types like hepatocytes and pancreatic beta cells. During phenotypic conversion, the monocytes downregulate monocyte/macrophage differentiation markers, being indicative of partial dedifferentiation, and are partially reprogrammed to acquire...

  9. Physical activity as a mediator of the impact of chronic conditions on quality of life in older adults

    Directory of Open Access Journals (Sweden)

    Miller William C

    2007-12-01

    Full Text Available Abstract Background Chronic conditions could negatively affect the quality of life of older adults. This may be partially due to a relative lack of physical activity. We examined whether physical activity mediates the relationship between different chronic conditions and several health outcomes that are important to the quality of life of older adults. Methods The data were taken from the Canadian Community Health Survey (cycle 1.1, a cross-section survey completed in 2001. Only respondents who were 65 years or older were included in our study (N = 22,432. The Health Utilities Index Mark 3 (HUI3 was used to measure overall quality of life, and to measure selected health outcomes (dexterity, mobility, pain, cognition, and emotional wellbeing that are considered to be of importance to the quality of life of older adults. Leisure-time physical activity was assessed by determining weekly energy expenditure (Kcal per week based on the metabolic equivalents of self-reported leisure activities. Linear and logistic regression models were used to determine the mediating effect of leisure-time physical activity while controlling for demographic variables (age and sex, substance use (tobacco use and alcohol consumption, and obesity. Results Having a chronic condition was associated with a relative decrease in health utility scores and a relative increase in mobility limitations, dexterity problems, pain, emotional problems (i.e., decreased happiness, and cognitive limitations. These negative consequences could be partially attributed to a relative lack of physical activity in older adults with a chronic condition (14% mediation for the HUI3 score. The corresponding degree of mediation was 18% for mobility limitations, 5% for pain, and 13% for emotional wellbeing (statistically significant mediation was not observed for the other health attributes. These values varied with respect to the different chronic conditions examined in our study. Conclusion Older

  10. Tenskinmetric Evaluation of Surface Energy Changes in Adult Skin: Evidence from 834 Normal Subjects Monitored in Controlled Conditions

    Directory of Open Access Journals (Sweden)

    Camilla Dal Bosco

    2014-03-01

    Full Text Available To evaluate the influence of the skin aging critical level on the adult skin epidermal functional state, an improved analytical method based on the skin surface energetic measurement (TVS modeling was developed. Tenskinmetric measurements were carried out non-invasively in controlled conditions by contact angle method using only a water-drop as reference standard liquid. Adult skin was monitored by TVS Observatory according to a specific and controlled thermal protocol (Camianta protocol in use at the interconnected “Mamma Margherita Terme spa” of Terme Euganee. From June to November 2013, the surface free energy and the epidermal hydration level of adult skin were evaluated on arrival of 265 male and 569 female adult volunteers (51–90 years of age and when they departed 2 weeks later. Sensitive measurements were carried out at 0.1 mN/m. High test compliance was obtained (93.2% of all guests. Very interesting results are obtained. The high sensitivity and discrimination power of tenskinmetry combined with a thermal Camianta protocol demonstrate the possibility to evaluate at baseline level the surface energetic changes and the skin reactivity which occurs on adult skin.

  11. Pharmacological reduction of adult hippocampal neurogenesis modifies functional brain circuits in mice exposed to a cocaine conditioned place preference paradigm.

    Science.gov (United States)

    Castilla-Ortega, Estela; Blanco, Eduardo; Serrano, Antonia; Ladrón de Guevara-Miranda, David; Pedraz, María; Estivill-Torrús, Guillermo; Pavón, Francisco Javier; Rodríguez de Fonseca, Fernando; Santín, Luis J

    2016-05-01

    We investigated the role of adult hippocampal neurogenesis in cocaine-induced conditioned place preference (CPP) behaviour and the functional brain circuitry involved. Adult hippocampal neurogenesis was pharmacologically reduced with temozolomide (TMZ), and mice were tested for cocaine-induced CPP to study c-Fos expression in the hippocampus and in extrahippocampal addiction-related areas. Correlational and multivariate analysis revealed that, under normal conditions, the hippocampus showed widespread functional connectivity with other brain areas and strongly contributed to the functional brain module associated with CPP expression. However, the neurogenesis-reduced mice showed normal CPP acquisition but engaged an alternate brain circuit where the functional connectivity of the dentate gyrus was notably reduced and other areas (the medial prefrontal cortex, accumbens and paraventricular hypothalamic nucleus) were recruited instead of the hippocampus. A second experiment unveiled that mice acquiring the cocaine-induced CPP under neurogenesis-reduced conditions were delayed in extinguishing their drug-seeking behaviour. But if the inhibited neurons were generated after CPP acquisition, extinction was not affected but an enhanced long-term CPP retention was found, suggesting that some roles of the adult-born neurons may differ depending on whether they are generated before or after drug-contextual associations are established. Importantly, cocaine-induced reinstatement of CPP behaviour was increased in the TMZ mice, regardless of the time of neurogenesis inhibition. The results show that adult hippocampal neurogenesis sculpts the addiction-related functional brain circuits, and reduction of the adult-born hippocampal neurons increases cocaine seeking in the CPP model. PMID:25870909

  12. Does Information Improve the Health Behavior of Adults Targeted by a Conditional Transfer Program?

    Science.gov (United States)

    Avitabile, Ciro

    2012-01-01

    We use data from the evaluation sample of Mexico's Food Assistance Program (PAL) to study whether including the attendance at health and nutrition classes among the requirements for receiving a transfer affects the health behavior of adults living in localities targeted by the program. The experimental trial has four different treatment types,…

  13. Prisoners' and Non-Institutional Adults' Perceptions of Conditions Affecting Their Learning.

    Science.gov (United States)

    Fagan, William T.

    1989-01-01

    A study used the Intellectual Achievement Responsibility Questionnaire and the Nowicki-Strickland Internal-External Control Scale to understand the nature of internal and external factors in the lives of two groups of low literate adults--26 prisoners and 26 persons in noninstitutional settings. Results showed that both groups attribute their…

  14. Effect of Breath Holding on Spleen Volume Measured by Magnetic Resonance Imaging.

    Directory of Open Access Journals (Sweden)

    Yusuke Inoue

    Full Text Available Ultrasonographic studies have demonstrated transient reduction in spleen volume in relation to apnea diving. We measured spleen volume under various respiratory conditions by MR imaging to accurately determine the influence of ordinary breath holding on spleen volumetry.Twelve healthy adult volunteers were examined. Contiguous MR images of the spleen were acquired during free breathing and during respiratory manipulations, including breath holding at the end of normal expiration, breath holding at deep inspiration, and the valsalva maneuver, and spleen volume was measured from each image set based on the sum-of-areas method. Acquisition during free breathing was performed with respiratory triggering. The duration of each respiratory manipulation was 30 s, and five sets of MR images were acquired serially during each manipulation.Baseline spleen volume before respiratory manipulation was 173.0 ± 79.7 mL, and the coefficient of variance for two baseline measures was 1.4% ± 1.6%, suggesting excellent repeatability. Spleen volume decreased significantly just after the commencement of respiratory manipulation, remained constant during the manipulation, and returned to the control value 2 min after the cessation of the manipulation, irrespective of manipulation type. The percentages of volume reduction were 10.2% ± 2.9%, 10.2% ± 3.5%, and 13.3% ± 5.7% during expiration breath holding, deep-inspiration breath holding, and the valsalva maneuver, respectively, and these values did not differ significantly.Spleen volume is reduced during short breath-hold apnea in healthy adults. Physiological responses of the spleen to respiratory manipulations should be considered in the measurement and interpretation of spleen volume.

  15. Periodontal conditions in 35-44 and 65-74-year-old adults in Denmark

    DEFF Research Database (Denmark)

    Krustrup, Ulla; Petersen, Poul Erik

    2006-01-01

    OBJECTIVES: To assess the periodontal health status in the Danish adult population and to analyze how the level of periodontal health is associated with age, gender, urbanization, socio-economic factors, and dental visiting habits; furthermore, to compare the periodontal health status of Danish...... teeth with shallow and deep pockets than those with high education. Persons with regular dental visiting habits had fewer teeth with gingival bleeding, shallow and deep pockets than individuals with irregular dental visiting habits. CONCLUSION: Reorientation of the Danish dental health-care services is...... needed with further emphasis on preventive care, and public health programs should focus on risk factors shared by chronic diseases in order to improve the periodontal health of Danish adults....

  16. Holding the Tension.

    Science.gov (United States)

    Feudtner, Chris

    2016-05-01

    My colleagues and I had been asked by a member of a clinical team to help sort through the ethics of stopping a life-sustaining intervention for a very ill child. We had already talked with the parents, the physicians, and the folks from nursing, social work, and chaplaincy. Terms like "suffering," "cruel," "compassion," and "moral distress" had been uttered, as had terms like "inappropriate," "unethical," "neglectful," and "risk-management." The group had now stuffed all of these polarizing thoughts and feelings into this cramped room with only one door. And everyone was looking at me. What skill, competency, or inner capacity must one possess to hold and manage such tension? PMID:27150423

  17. Effect of electric barrier on passage and physical condition of juvenile and adult rainbow trout

    Science.gov (United States)

    Layhee, Megan J.; Sepulveda, Adam; Shaw, Amy; Smuckall, Matthew; Kapperman, Kevin; Reyes, Alejandro

    2016-01-01

    Electric barriers can inhibit passage and injure fish. Few data exist on electric barrier parameters that minimize these impacts and on how body size affects susceptibility, especially to nontarget fish species. The goal of this study was to determine electric barrier voltage and pulse-width settings that inhibit passage of larger bodied rainbow trout Oncorhynchus mykiss (215–410 mm fork length) while allowing passage of smaller bodied juvenile rainbow trout (52–126 mm) in a static laboratory setting. We exposed rainbow trout to 30-Hz pulsed-direct current voltage gradients (0.00–0.45 V cm−1) and pulse widths (0.0–0.7 ms) and recorded their movement, injury incidence, and mortality. No settings tested allowed all juveniles to pass while impeding all adult passage. Juvenile and adult rainbow trout avoided the barrier at higher pulse widths, and fewer rainbow trout passed the barrier at 0.7-ms pulse width compared to 0.1 ms and when the barrier was turned off. We found no effect of voltage gradient on fish passage. No mortality occurred, and we observed external bruising in 5 (7%) juvenile rainbow trout and 15 (21%) adult rainbow trout. This study may aid managers in selecting barrier settings that allow for increased juvenile passage.

  18. Person-Centered Care for Older Adults with Chronic Conditions and Functional Impairment: A Systematic Literature Review.

    Science.gov (United States)

    Kogan, Alexis Coulourides; Wilber, Kathleen; Mosqueda, Laura

    2016-01-01

    Person-centered care (PCC) shifts focus away from the traditional biomedical model in favor of embracing personal choice and autonomy for people receiving health services. It has become an important avenue for improving primary care, and older adults remain a priority target for PCC because they are more likely to have complex care needs than younger individuals. Nevertheless, despite a growing body of evidence regarding its use, PCC still lacks an agreed-upon definition. A literature review was conducted to explore extant scholarship on PCC for older adults, assess corresponding definitions of PCC, and identify important elements of quality PCC. Nearly 3,000 articles published between 1990 and 2014 were identified. Excluding search results outside the parameters of this study, the final review comprised 132 nonduplicate sources focused on patient-centered care or PCC in older adults. Fifteen descriptions of PCC were identified, addressing 17 central principles or values. The six most-prominent domains of PCC were holistic or whole-person care, respect and value, choice, dignity, self-determination, and purposeful living. The body of evidence reviewed suggests that PCC is an important area of growing interest. Although multiple definitions and elements of PCC abound-with many commonalities and some overlap-the field would benefit from a consensus definition and list of essential elements to clarify how to operationalize a PCC approach to health care and services for older adults. This work guided the development of a separate American Geriatrics Society expert panel statement presenting a standardized definition and a list of PCC elements for older adults with chronic conditions or functional impairment. PMID:26626408

  19. Periodontal conditions and associated factors among adults and the elderly: findings from the first National Oral Health Survey in Uruguay.

    Science.gov (United States)

    Lorenzo, Susana M; Alvarez, Ramón; Andrade, Ernesto; Piccardo, Virginia; Francia, Alejandro; Massa, Fernando; Correa, Marcos Britto; Peres, Marco Aurélio

    2015-11-01

    The aims of this study were to assess the prevalence of periodontal conditions in the Uruguayan adult and elderly population and its association with socioeconomic and behavioral characteristics. Data from adults (35-44, n = 358) and elderly (65-74, n = 411) who participated in the first National Oral Health Survey, Uruguay, 2011, were used. The survey included a household questionnaire addressing socioeconomic characteristics, and tobacco use. Bleeding on probing (BOP), periodontal pockets (CPI) and clinical attachment loss (CAL) were measured by clinical examination. A multivariable analysis was carried out. Considering both age groups, the prevalence of mild/severe periodontal disease was 21.8% and 9.12% for severe periodontal disease. Adjusted analyses revealed an association between high education and all outcomes. Attendance at dental services was negatively associated with BOP and mild to severe periodontitis. Periodontal outcomes were higher in disadvantaged socioeconomic groups. Tobacco consumption has a strong association with periodontal disease in the elderly. PMID:26840821

  20. Impact of conditioning with TBI in adult patients with T-cell ALL who receive a myeloablative allogeneic stem cell transplantation

    DEFF Research Database (Denmark)

    Cahu, X; Labopin, M; Giebel, S;

    2016-01-01

    Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a therapeutic option for adult patients with T-cell ALL (T-ALL). Meanwhile, few allo-SCT data specific to adult T-ALL have been described thus far. Specifically, the optimal myeloablative conditioning regimen is unknown. In this...

  1. Lower conditioning leisure-time physical activity in young adults born preterm at very low birth weight.

    Directory of Open Access Journals (Sweden)

    Nina Kaseva

    Full Text Available BACKGROUND: Adults born preterm at very low birth weight (VLBW, <1500 g have elevated levels of risk factors for cardiovascular diseases and type 2 diabetes. Preliminary observations suggest that this could partly be explained by lower rates of physical activity. The aim of this study was to assess physical activity in healthy young adults born preterm at very low birth weight compared with term-born controls. METHODOLOGY/PRINCIPAL FINDINGS: We studied 94 unimpaired young adults, aged 21-29 years, born at VLBW and 101 age-, sex-, and birth hospital-matched term-born controls from one regional center in Southern Finland. The participants completed a validated 30-item 12-month physical activity questionnaire and the NEO-Personality Inventory based on the Big Five taxonomy, the most commonly used classification of personality traits. Yearly frequency, total time, total volume and energy expenditure of conditioning and non-conditioning leisure-time physical activity (LTPA and commuting physical activity were compared between VLBW and term-born subjects. A subset of participants underwent dual-energy x-ray absorptiometry for body composition measurement. Data were analyzed by multiple linear regression. Compared with controls, VLBW participants had lower frequency [-38.5% (95% CI; -58.9, -7.7], total time [-47.4% (95% CI; -71.2, -4.1], total volume [-44.3% (95% CI; -65.8, -9.2] and energy expenditure [-55.9% (95% CI; -78.6, -9.4] of conditioning LTPA when adjusted for age, sex, body mass index, smoking, parental education and personality traits. Adjusting for lean body mass instead of body mass index attenuated the difference. There were no differences in non-conditioning LTPA or commuting physical activity. CONCLUSIONS/SIGNIFICANCE: Compared with term-born controls, unimpaired VLBW adults undertake less frequent LTPA with lower total time and volume of exercise resulting in lower energy expenditure. Differences in personality that exist between the

  2. Embryonic Methamphetamine Exposure Inhibits Methamphetamine Cue Conditioning and Reduces Dopamine Concentrations in Adult N2 Caenorhabditis elegans.

    Science.gov (United States)

    Katner, Simon N; Neal-Beliveau, Bethany S; Engleman, Eric A

    2016-01-01

    Methamphetamine (MAP) addiction is substantially prevalent in today's society, resulting in thousands of deaths and costing billions of dollars annually. Despite the potential deleterious consequences, few studies have examined the long-term effects of embryonic MAP exposure. Using the invertebrate nematode Caenorhabditis elegans allows for a controlled analysis of behavioral and neurochemical changes due to early developmental drug exposure. The objective of the current study was to determine the long-term behavioral and neurochemical effects of embryonic exposure to MAP in C. elegans. In addition, we sought to improve our conditioning and testing procedures by utilizing liquid filtration, as opposed to agar, and smaller, 6-well testing plates to increase throughput. Wild-type N2 C. elegans were embryonically exposed to 50 μM MAP. Using classical conditioning, adult-stage C. elegans were conditioned to MAP (17 and 500 μM) in the presence of either sodium ions (Na+) or chloride ions (Cl-) as conditioned stimuli (CS+/CS-). Following conditioning, a preference test was performed by placing worms in 6-well test plates spotted with the CS+ and CS- at opposite ends of each well. A preference index was determined by counting the number of worms in the CS+ target zone divided by the total number of worms in the CS+ and CS- target zones. A food conditioning experiment was also performed in order to determine whether embryonic MAP exposure affected food conditioning behavior. For the neurochemical experiments, adult worms that were embryonically exposed to MAP were analyzed for dopamine (DA) content using high-performance liquid chromatography. The liquid filtration conditioning procedure employed here in combination with the use of 6-well test plates significantly decreased the time required to perform these experiments and ultimately increased throughput. The MAP conditioning data found that pairing an ion with MAP at 17 or 500 μM significantly increased the preference

  3. Allergic conditions and risk of hematological malignancies in adults: a cohort study

    Directory of Open Access Journals (Sweden)

    Schwartzbaum Judith

    2004-11-01

    Full Text Available Abstract Background Two contradictory hypotheses have been proposed to explain the relationship between allergic conditions and malignancies, the immune surveillance hypothesis and the antigenic stimulation hypothesis. The former advocates that allergic conditions may be protective against development of cancer, whereas the latter proposes an increased risk. This relationship has been studied in several case-control studies, but only in a few cohort studies. Methods The association between allergic conditions and risk of developing leukemia, Hodgkin's disease, non-Hodgkin's lymphoma and myeloma was investigated in a cohort of 16,539 Swedish twins born 1886–1925. Prospectively collected, self-reported information about allergic conditions such as asthma, hay fever or eczema was obtained through questionnaires administered in 1967. The cohort was followed 1969–99 and cancer incidence was ascertained from the Swedish Cancer Registry. Results Hives and asthma tended to increase the risk of leukemia (relative risk [RR] = 2.1, 95% Confidence Interval [CI] 1.0–4.5 and RR = 1.6, 95% CI 0.8–3.5, respectively. There was also an indication of an increased risk of non-Hodgkin's lymphoma associated with eczema during childhood (RR = 2.3, 95% CI 1.0–5.3. Conclusion In contrast to most previous studies, our results do not indicate a protective effect of allergic conditions on the risk of developing hematological malignancies. Rather, they suggest that allergic conditions might increase the risk of some hematological malignancies.

  4. Adolescent and adult rats differ in the amnesic effects of acute ethanol in two hippocampus-dependent tasks: Trace and contextual fear conditioning.

    Science.gov (United States)

    Hunt, Pamela S; Barnet, Robert C

    2016-02-01

    Experience-produced deficits in trace conditioning and context conditioning have been useful tools for examining the role of the hippocampus in learning. It has also been suggested that learning in these tasks is especially vulnerable to neurotoxic effects of alcohol during key developmental periods such as adolescence. In five experiments we systematically examined the presence and source of age-dependent vulnerability to the memory-disrupting effects of acute ethanol in trace conditioning and contextual fear conditioning. In Experiment 1a pre-training ethanol disrupted trace conditioning more strongly in adolescent (postnatal day, PD30-35) than adult rats (PD65-75). In Experiment 1b when pre-training ethanol was accompanied by pre-test ethanol no deficit in trace conditioning was observed in adolescents, suggesting that state-dependent retrieval failure mediated ethanol's disruption of trace conditioning at this age. Experiment 2a and b examined the effect of ethanol pretreatment on context conditioning. Here, adult but not adolescent rats were impaired in conditioned freezing to context cues. Experiment 2c explored state-dependency of this effect. Pre-training ethanol continued to disrupt context conditioning in adults even when ethanol was also administered prior to test. Collectively these findings reveal clear age-dependent and task-dependent vulnerabilities in ethanol's disruptive effects on hippocampus-dependent memory. Adolescents were more disrupted by ethanol in trace conditioning than adults, and adults were more disrupted by ethanol in context conditioning than adolescents. We suggest that adolescents may be more susceptible to changes in internal state (state-dependent retrieval failure) than adults and that ethanol disrupted performance in trace and context conditioning through different mechanisms. Relevance of these findings to theories of hippocampus function is discussed. PMID:26192910

  5. Increased adult hippocampal neurogenesis is not necessary for wheel running to abolish conditioned place preference for cocaine in mice.

    Science.gov (United States)

    Mustroph, M L; Merritt, J R; Holloway, A L; Pinardo, H; Miller, D S; Kilby, C N; Bucko, P; Wyer, A; Rhodes, J S

    2015-01-01

    Recent evidence suggests that wheel running can abolish conditioned place preference (CPP) for cocaine in mice. Running significantly increases the number of new neurons in the hippocampus, and new neurons have been hypothesised to enhance plasticity and behavioral flexibility. Therefore, we tested the hypothesis that increased neurogenesis was necessary for exercise to abolish cocaine CPP. Male nestin-thymidine kinase transgenic mice were conditioned with cocaine, and then housed with or without running wheels for 32 days. Half of the mice were fed chow containing valganciclovir to induce apoptosis in newly divided neurons, and the other half were fed standard chow. For the first 10 days, mice received daily injections of bromodeoxyuridine (BrdU) to label dividing cells. On the last 4 days, mice were tested for CPP, and then euthanized for measurement of adult hippocampal neurogenesis by counting the number of BrdU-positive neurons in the dentate gyrus. Levels of running were similar in mice fed valganciclovir-containing chow and normal chow. Valganciclovir significantly reduced the numbers of neurons (BrdU-positive/NeuN-positive) in the dentate gyrus of both sedentary mice and runner mice. Valganciclovir-fed runner mice showed similar levels of neurogenesis as sedentary, normal-fed controls. However, valganciclovir-fed runner mice showed the same abolishment of CPP as runner mice with intact neurogenesis. The results demonstrate that elevated adult hippocampal neurogenesis resulting from running is not necessary for running to abolish cocaine CPP in mice. PMID:25393660

  6. Increases in the numerical density of GAT-1 positive puncta in the barrel cortex of adult mice after fear conditioning.

    Directory of Open Access Journals (Sweden)

    Ewa Siucinska

    Full Text Available Three days of fear conditioning that combines tactile stimulation of a row of facial vibrissae (conditioned stimulus, CS with a tail shock (unconditioned stimulus, UCS expands the representation of "trained" vibrissae, which can be demonstrated by labeling with 2-deoxyglucose in layer IV of the barrel cortex. We have also shown that functional reorganization of the primary somatosensory cortex (S1 increases GABAergic markers in the hollows of "trained" barrels of the adult mouse. This study investigated how whisker-shock conditioning (CS+UCS affected the expression of puncta of a high-affinity GABA plasma membrane transporter GAT-1 in the barrel cortex of mice 24 h after associative learning paradigm. We found that whisker-shock conditioning (CS+UCS led to increase expression of neuronal and astroglial GAT-1 puncta in the "trained" row compared to controls: Pseudoconditioned, CS-only, UCS-only and Naïve animals. These findings suggest that fear conditioning specifically induces activation of systems regulating cellular levels of the inhibitory neurotransmitter GABA.

  7. Social relations and filial maturity in middle-aged adults: contextual conditions and psychological determinants.

    Science.gov (United States)

    Perrig-Chiello, P; Sturzenegger, M

    2001-02-01

    The aim of this paper is to highlight the contextual and psychological preconditions of parent help and helpfulness in a sample of 260 middle-aged persons belonging to two age groups, 40-45 years and 50-55 years. In a first step we want to focus on the description of the contextual situation of the persons of this "hinge generation": What are their available social networks; what are their commitments towards children and parents in terms of perceived obligation and investment; how is their perceived balance of giving and receiving; how do they anticipate and experience dependency of their parents? In a second step we will highlight the readiness of middle-aged women and men to help their parents as well as the effectively reported help. Here we are interested in the psychological determinants of such attitude and behaviour. Structural equation models are performed to estimate the predictory power of personality variables, control beliefs and reported stress (family and job) on filial helpfulness and help. Results suggest that differential aspects such as gender and age group explain a large amount of variance of the variables intergenerational commitment and satisfaction with social networks and have--along with personality variables--a strong impact on filial help and helpfulness of middle-aged adults. PMID:11310223

  8. The Impact of Listening Condition on Background Noise Acceptance for Young Adults with Normal Hearing

    Science.gov (United States)

    Gordon-Hickey, Susan; Moore, Robert E.; Estis, Julie M.

    2012-01-01

    Purpose: To evaluate the effect of different speech conditions on background noise acceptance. A total of 23 stimulus pairings, differing in primary talker gender (female, male, conventional), number of background talkers (1, 4, 12), and gender composition of the background noise (female, male, mixed) were used to evaluate background noise…

  9. Relationships between nutritional condition of adult females and relative carrying capacity for rocky mountain Elk

    Science.gov (United States)

    Piasecke, J.R.; Bender, L.C.

    2009-01-01

    Lactation can have significant costs to individual and population-level productivity because of the high energetic demands it places on dams. Because the difference in condition between lactating and dry Rocky Mountain elk (Cervus elaphus nelsoni) cows tends to disappear as nutritional quality rises, the magnitude of that difference could be used to relate condition to habitat quality or the capability of habitats to support elk. We therefore compared nutritional condition of ???2.5-yr-old lactating and dry cows from six free-ranging RockyMountain elk populations throughout the United States.Our goal was to quantify differential accrual of body fat (BF) reserves to determine whether the condition of dry and lactating cows could be used to define relevant management thresholds of habitat quality (i.e., relative carrying capacity) and consequently potential performance of elk populations. Levels of BF that lactating cows were able to accrue in autumn and the proportional difference in BF between dry and lactating cows in autumn were related (F 1-2,10???16.2, Pnutritionally stressed condition, which may be limiting population performance. Using the logistic model to predict relative proximity to ecological carrying capacity (ECC), our population-years ranged from3-97%ofECCand proportion of the population lactating (an index of calf survival) was negatively related to proportion of ECC. Results indicate that the proportional difference in accrual of BF between lactating and dry cows can provide a sensitive index to where elk populations reside relative to the quality of their range.

  10. Mure skal holde zombierne ude

    DEFF Research Database (Denmark)

    Stockmarr, Leila

    2013-01-01

    Vi bygger som besatte mure og barrierer for at holde flygtninge ude og tæmme de negative konsekvenser af den neoliberale globalisering.......Vi bygger som besatte mure og barrierer for at holde flygtninge ude og tæmme de negative konsekvenser af den neoliberale globalisering....

  11. Are early onset aging conditions correlated to daily activity functions in youth and adults with Down syndrome?

    Science.gov (United States)

    Lin, Jin-Ding; Lin, Lan-Ping; Hsu, Shang-Wei; Chen, Wen-Xiu; Lin, Fu-Gong; Wu, Jia-Ling; Chu, Cordia

    2014-11-13

    This study aims to answer the research question of "Are early onset aging conditions correlated to daily activity functions in youth and adults with Down syndrome (DS)?" A cross-sectional survey was employed to recruit 216 individuals with DS over 15 years of age in the analyses. A structured questionnaire included demographic data, brief self-reported aging conditions, Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID) and activity of daily living (ADL) scales were completed by the primary caregivers who were well-suited for providing information on the functioning conditions of the DS individuals. Results showed that the most five frequent aging conditions (sometimes, usually and always) included frailty (20.2%), vision problem (15.8%), loss of language ability (15.3%), sleep problem (14.9%) and memory impairment (14.5%). Other onset aging conditions included more chronic diseases (13.9%), hearing loss (13%), chewing ability and tooth loss (12.5%), incontinence (11.1%), depressive syndrome (7.7%), falls and gait disorder (7.2%), loss of taste and smell (7.2%). The data also showed scores of DSQIID, onset aging conditions and ADL has significant relationships each other in Pearson's correlation tests. Finally, multiple linear regression analyses indicated onset aging conditions (β=-0.735, p<0.001) can significantly predicted the variation in ADL scores after adjusting other factors (R(2)=0.381). This study suggests that the authority should initiate early intervention programs aim to improve healthy aging and ADL functions for people with DS. PMID:25462513

  12. Obesity and Malnutrition: Impact of Habitat and Living Conditions in Adult Urban Population in Argentina

    OpenAIRE

    Karina Temporelli; Valentina Viego

    2015-01-01

    Introduction: malnutrition refers to imbalances (either deficit or excess) in energy intake, protein and / or nutrients including underweight and obesity. The aim of this work is identify the contribution of individual factors, habits and life conditions in nutritional status. Material and methods: estimates of relative risk ratios are obtained from a multinomial logistic model using microdata from the National Survey of Risk Factors conducted in 2005 and 2009 in Argentinean‘ cities among adu...

  13. Nestin Expression in Embryonic and Adult Human Teeth under Normal and Pathological Conditions

    OpenAIRE

    About, Imad; Laurent-Maquin, Dominique; Lendahl, Urban; Mitsiadis, Thimios A.

    2000-01-01

    Nestin is an intermediate filament most related to neurofilaments and expressed predominantly in the developing nervous system and muscles. In the present study we examined the in vivo distribution of nestin in human teeth during embryonic development and in permanent teeth under normal and pathological conditions. The results show that nestin is first expressed at the bell stage and that its distribution is restricted in pulpal cells located at the cusp area of the fetal teeth. In young perm...

  14. Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy

    OpenAIRE

    Lai, Ka-Man V.; Gonzalez, Michael; Poueymirou, William T.; Kline, William O.; Na, Erqian; Zlotchenko, Elizabeth; Stitt, Trevor N.; Economides, Aris N.; Yancopoulos, George D.; Glass, David J.

    2004-01-01

    Skeletal muscle atrophy is a severe morbidity caused by a variety of conditions, including cachexia, cancer, AIDS, prolonged bedrest, and diabetes. One strategy in the treatment of atrophy is to induce the pathways normally leading to skeletal muscle hypertrophy. The pathways that are sufficient to induce hypertrophy in skeletal muscle have been the subject of some controversy. We describe here the use of a novel method to produce a transgenic mouse in which a constitutively active form of Ak...

  15. Adolescent social defeat increases adult amphetamine conditioned place preference and alters D2 dopamine receptor expression

    OpenAIRE

    Burke, Andrew R.; Watt, Michael J.; Forster, Gina L.

    2011-01-01

    Components of the brain’s dopaminergic system, such as dopamine receptors, undergo final maturation in adolescence. Exposure to social stress during human adolescence contributes to substance abuse behaviors. We utilized a rat model of adolescent social stress to investigate the neural mechanisms underlying this correlation. Rats exposed to repeated social defeat in adolescence (P35–P39) exhibited increased conditioned place preference (CPP) for amphetamine (1 mg/kg) in adulthood (P70). In co...

  16. The food-conditioned place preference task in adolescent, adult and aged rats of both sexes

    OpenAIRE

    Rubinow, Marisa J.; Hagerbaumer, Diana A.; Juraska, Janice M.

    2008-01-01

    The rat basolateral amygdala shows neuroanatomical sex differences, continuing development after puberty and aging-related alterations. Implications for amygdala-dependent memory processes were explored here by testing male and female hooded rats in adolescence, adulthood and old age on the food-conditioned place preference task. While aged rats were unimpaired, adolescents failed to learn the task. This finding may be related to ongoing development of the basolateral amygdala and related mem...

  17. Sensory Bias Predicts Postural Stability, Anxiety, and Cognitive Performance in Healthy Adults Walking in Novel Discordant Conditions

    Science.gov (United States)

    Brady, Rachel A.; Batson, Crystal D.; Peters, Brian T.; Mulavara, Ajitkumar P.; Bloomberg, Jacob J.

    2010-01-01

    We designed a gait training study that presented combinations of visual flow and support surface manipulations to investigate the response of healthy adults to novel discordant sensorimotor conditions. We aimed to determine whether a relationship existed between subjects visual dependence and their scores on a collective measure of anxiety, cognition, and postural stability in a new discordant environment presented at the conclusion of training (Transfer Test). A treadmill was mounted to a motion base platform positioned 2 m behind a large visual screen. Training consisted of three walking sessions, each within a week of the previous visit, that presented four 5-minute exposures to various combinations of support surface and visual scene manipulations, all lateral sinusoids. The conditions were scene translation only, support surface translation only, simultaneous scene and support surface translations in-phase, and simultaneous scene and support surface translations 180 out-of-phase. During the Transfer Test, the trained participants received a 2-minute novel exposure. A visual sinusoidal roll perturbation, with twice the original flow rate, was superimposed on a sinusoidal support surface roll perturbation that was 90 out of phase with the scene. A high correlation existed between normalized torso translation, measured in the scene-only condition at the first visit, and a combined measure of normalized heart rate, stride frequency, and reaction time at the transfer test. Results suggest that visually dependent participants experience decreased postural stability, increased anxiety, and increased reaction times compared to their less visually dependent counterparts when negotiating novel discordant conditions.

  18. Chemical immobilization of adult female Weddell seals with tiletamine and zolazepam: effects of age, condition and stage of lactation

    Directory of Open Access Journals (Sweden)

    Harcourt Robert G

    2006-02-01

    Full Text Available Abstract Background Chemical immobilization of Weddell seals (Leptonychotes weddellii has previously been, for the most part, problematic and this has been mainly attributed to the type of immobilizing agent used. In addition to individual sensitivity, physiological status may play an important role. We investigated the use of the intravenous administration of a 1:1 mixture of tiletamine and zolazepam (Telazol® to immobilize adult females at different points during a physiologically demanding 5–6 week lactation period. We also compared performance between IV and IM injection of the same mixture. Results The tiletamine:zolazepam mixture administered intravenously was an effective method for immobilization with no fatalities or pronounced apnoeas in 106 procedures; however, there was a 25 % (one animal in four mortality rate with intramuscular administration. Induction time was slightly longer for females at the end of lactation (54.9 ± 2.3 seconds than at post-parturition (48.2 ± 2.9 seconds. In addition, the number of previous captures had a positive effect on induction time. There was no evidence for effects due to age, condition (total body lipid, stage of lactation or number of captures on recovery time. Conclusion We suggest that intravenous administration of tiletamine and zolazepam is an effective and safe immobilizing agent for female Weddell seals. Although individual traits could not explain variation in recovery time, we suggest careful monitoring of recovery times during longitudinal studies (> 2 captures. We show that physiological pressures do not substantially affect response to chemical immobilization with this mixture; however, consideration must be taken for differences that may exist for immobilization of adult males and juveniles. Nevertheless, we recommend a mass-specific dose of 0.50 – 0.65 mg/kg for future procedures with adult female Weddell seals and a starting dose of 0.50 mg/kg for other age classes and other

  19. The effect of environmental conditions on viability of irradiated codling moth Cydia Pomonella (L.) adults

    International Nuclear Information System (INIS)

    Cooled (4 ± 2 Centigrade) codling moth, Cydia pomonella (L.) males exposed to dose of 350 Gy were released in apple orchards starting at 6:00 o'clock in the morning until 4:00 in the afternoon at 2 h. intervals. Moths were released in shade (under trees) or in the sun (between trees), the number of dead moths after 20 minutes of release were recorded, percentage mortality was calculated and compared with unirradiated controls. The effect of ambient temperature and relative humidity on moth survival and activity was evaluated by counting the number of caught males by pheromone traps. Results showed that percentage mortality increased with increase in temperature and decrease in relative humidity and reached to 82% at 30 Centigrade and 40% Rh., when irradiated moths were released under direct sun shine. However, when moths were released in the shade under the same conditions, survival rate was as high as 91%. Results also showed that percentage survival in irradiated males was less than in the control when moths were released under direct sunshine. Results of monitoring moth activity also showed that pheromone trap continued to catch males for up to 8 days which may suggests that released males lived under field conditions for no less than one week. (author)

  20. Social conditions and urban environment associated with participation in the Ciclovia program among adults from Cali, Colombia.

    Science.gov (United States)

    Gómez, Luis Fernando; Mosquera, Janeth; Gómez, Olga Lucia; Moreno, José; Pinzon, Jose D; Jacoby, Enrique; Cepeda, Magda; Parra, Diana Celmira

    2015-11-01

    The Ciclovia program (CP) has emerged as an effective initiative to promote active living in urban spaces in Latin America. This study assessed the association between social conditions, the urban environment and participation in the CP among adults living in the city of Cali, Colombia. A cross-sectional study was conducted in 2011 and 2012 among 719 adults aged 18 to 44. Urban environment measures were obtained using Geographic Information Systems. A multilevel logistic regression was used for the analysis. Slightly more than 7% of participants had participated in the CP in the previous four weekends. Being male and having a high school degree were positively associated with participation in the CP. Participation in the CP was positively associated with living in neighborhoods with Ciclovia lanes. In contrast, a negative association was found among those living in neighborhoods with a presence of traffic fatalities. This study provides new insights about a recreational program that has potential health benefits in a region marked by urban inequalities in terms of opportunities for physical activity. PMID:26648379

  1. Social conditions and urban environment associated with participation in the Ciclovia program among adults from Cali, Colombia

    Directory of Open Access Journals (Sweden)

    Luis Fernando Gómez

    2015-11-01

    Full Text Available Abstract The Ciclovia program (CP has emerged as an effective initiative to promote active living in urban spaces in Latin America. This study assessed the association between social conditions, the urban environment and participation in the CP among adults living in the city of Cali, Colombia. A cross-sectional study was conducted in 2011 and 2012 among 719 adults aged 18 to 44. Urban environment measures were obtained using Geographic Information Systems. A multilevel logistic regression was used for the analysis. Slightly more than 7% of participants had participated in the CP in the previous four weekends. Being male and having a high school degree were positively associated with participation in the CP. Participation in the CP was positively associated with living in neighborhoods with Ciclovia lanes. In contrast, a negative association was found among those living in neighborhoods with a presence of traffic fatalities. This study provides new insights about a recreational program that has potential health benefits in a region marked by urban inequalities in terms of opportunities for physical activity.

  2. Periodontal conditions and associated factors among adults and the elderly: findings from the first National Oral Health Survey in Uruguay

    Directory of Open Access Journals (Sweden)

    Susana M. Lorenzo

    2015-11-01

    Full Text Available Abstract The aims of this study were to assess the prevalence of periodontal conditions in the Uruguayan adult and elderly population and its association with socioeconomic and behavioral characteristics. Data from adults (35-44, n = 358 and elderly (65-74, n = 411 who participated in the first National Oral Health Survey, Uruguay, 2011, were used. The survey included a household questionnaire addressing socioeconomic characteristics, and tobacco use. Bleeding on probing (BOP, periodontal pockets (CPI and clinical attachment loss (CAL were measured by clinical examination. A multivariable analysis was carried out. Considering both age groups, the prevalence of mild/severe periodontal disease was 21.8% and 9.12% for severe periodontal disease. Adjusted analyses revealed an association between high education and all outcomes. Attendance at dental services was negatively associated with BOP and mild to severe periodontitis. Periodontal outcomes were higher in disadvantaged socioeconomic groups. Tobacco consumption has a strong association with periodontal disease in the elderly.

  3. Effects of different drying conditions on the rehydration ratio and water holding capacity properties in three different species of algae Ulva lactuca, Codium vermilara and Codium tomentosum

    OpenAIRE

    Paulo Marques Nunes

    2014-01-01

    Over the last years, algae have been increasingly used in Human food due their rich chemical and nutritional composition, particularly the high supply of essential nutrients to the human body such as protein and dietary fiber. Dietary fiber can be divided into two different types: soluble and insoluble. The characteristics of soluble dietary fiber are related to some physical and chemical properties such as rehydration ratio and water holding capacity and are important in assigning the fun...

  4. The study of oral conditions by the full mouth roentgenograms in young adults

    International Nuclear Information System (INIS)

    The author examined 515 full mouth roentgenograms stored in the Dept. of Oral Radiology, college of Dentistry, Seoul National University. For evaluating the efficiency of the routine full mouth roentgenograms, each of abnormal conditions such as impacted teeth, missing, caries, crown, filling and apical lesions was observed. The results obtained were as follows; 1. Among 14.420 teeth examined, missing teeth were 174, impacted 16, caries 161 and treated, 162. 2. The incidence of impacted third molar was close to 18.7 percent and the incidence of missing third molar was about 33.4 percent. 3. Among carious and treated teeth, 178 teeth (1.2%) were needed observation of root apex. 4. There is a considerable relation between the incidence or size of apical lesion and the accuracy of endodontical treat. 5. Among the teeth with apical lesion, upper and lower first molars were most frequent (about 41%), upper and lower canine were rare (about 1.7%).

  5. Exemplifying whole-plant ozone uptake in adult forest trees of contrasting species and site conditions

    International Nuclear Information System (INIS)

    Whole-tree O3 uptake was exemplified for Picea abies, Fagus sylvatica and Larix decidua in stands at high and low altitude and contrasting water availability through sap flow measurement in tree trunks, intrinsically accounting for drought and boundary layer effects on O3 flux. O3 uptake of evergreen spruce per unit foliage area was enhanced by 100% at high relative to low elevation, whereas deciduous beech and larch showed similar uptake regardless of altitude. The responsiveness of the canopy conductance to water vapor and, as a consequence, O3 uptake to soil moisture and air humidity did not differ between species. Unifying findings at the whole-tree level will promote cause-effect based O3 risk assessment and modeling. - Sap flow-based assessment of whole-tree O3 uptake reflects similar responsiveness of canopy conductance and O3 uptake across contrasting tree species and site conditions

  6. State and Regional Prevalence of Diagnosed Multiple Chronic Conditions Among Adults Aged ≥18 Years - United States, 2014.

    Science.gov (United States)

    Ward, Brian W; Black, Lindsey I

    2016-01-01

    The prevalence and care management of multiple (two or more) chronic conditions (MCC) are important public health concerns (1). Approximately 25% of U.S. adults have diagnoses of MCC (2). Care management of MCC presents a challenge to both patients and providers because of the substantial costs associated with treating more than one condition and the traditional care strategies that focus on single conditions as opposed to enhanced care coordination (3,4). Maintaining surveillance, targeting service delivery, and projecting resources are all important to meet this challenge, and these actions can be informed by identifying state and other regional variations in MCC prevalence (5,6). Data from the 2014 National Health Interview Survey (NHIS) were used to estimate prevalence of MCC (defined as two or more of 10 diagnosed chronic conditions) for each U.S. state and region by age and sex. Significant state and regional variation in MCC prevalence was found, with state-level estimates ranging from 19.0% in Colorado to 38.2% in Kentucky. MCC prevalence also varied by region, ranging from 21.4% in the Pacific region to 34.5% in the East South Central region. The prevalence of MCC was higher among women than among men within certain U.S. regions, and was higher in older persons in all regions. Such findings further the research and surveillance objectives stated in the U.S. Department of Health and Human Services (HHS) publication, Multiple Chronic Conditions: A Strategic Framework (1). Furthermore, geographic disparities in MCC prevalence can inform state-level surveillance programs and groups targeting service delivery or allocating resources for MCC prevention activities. PMID:27467707

  7. Uncertainty Quantification for Cargo Hold Fires

    CERN Document Server

    DeGennaro, Anthony M; Martinelli, Luigi; Rowley, Clarence W

    2015-01-01

    The purpose of this study is twofold -- first, to introduce the application of high-order discontinuous Galerkin methods to buoyancy-driven cargo hold fire simulations, second, to explore statistical variation in the fluid dynamics of a cargo hold fire given parameterized uncertainty in the fire source location and temperature. Cargo hold fires represent a class of problems that require highly-accurate computational methods to simulate faithfully. Hence, we use an in-house discontinuous Galerkin code to treat these flows. Cargo hold fires also exhibit a large amount of uncertainty with respect to the boundary conditions. Thus, the second aim of this paper is to quantify the resulting uncertainty in the flow, using tools from the uncertainty quantification community to ensure that our efforts require a minimal number of simulations. We expect that the results of this study will provide statistical insight into the effects of fire location and temperature on cargo fires, and also assist in the optimization of f...

  8. Pre-partum diet of adult female bearded seals in years of contrasting ice conditions.

    Directory of Open Access Journals (Sweden)

    Mark A Hindell

    Full Text Available Changing patterns of sea-ice distribution and extent have measurable effects on polar marine systems. Beyond the obvious impacts of key-habitat loss, it is unclear how such changes will influence ice-associated marine mammals in part because of the logistical difficulties of studying foraging behaviour or other aspects of the ecology of large, mobile animals at sea during the polar winter. This study investigated the diet of pregnant bearded seals (Erignathus barbatus during three spring breeding periods (2005, 2006 and 2007 with markedly contrasting ice conditions in Svalbard using stable isotopes (δ(13C and δ(15N measured in whiskers collected from their newborn pups. The δ(15N values in the whiskers of individual seals ranged from 11.95 to 17.45 ‰, spanning almost 2 full trophic levels. Some seals were clearly dietary specialists, despite the species being characterised overall as a generalist predator. This may buffer bearded seal populations from the changes in prey distributions lower in the marine food web which seems to accompany continued changes in temperature and ice cover. Comparisons with isotopic signatures of known prey, suggested that benthic gastropods and decapods were the most common prey. Bayesian isotopic mixing models indicated that diet varied considerably among years. In the year with most fast-ice (2005, the seals had the greatest proportion of pelagic fish and lowest benthic invertebrate content, and during the year with the least ice (2006, the seals ate more benthic invertebrates and less pelagic fish. This suggests that the seals fed further offshore in years with greater ice cover, but moved in to the fjords when ice-cover was minimal, giving them access to different types of prey. Long-term trends of sea ice decline, earlier ice melt, and increased water temperatures in the Arctic are likely to have ecosystem-wide effects, including impacts on the forage bases of pagophilic seals.

  9. Pre-partum diet of adult female bearded seals in years of contrasting ice conditions.

    Science.gov (United States)

    Hindell, Mark A; Lydersen, Christian; Hop, Haakon; Kovacs, Kit M

    2012-01-01

    Changing patterns of sea-ice distribution and extent have measurable effects on polar marine systems. Beyond the obvious impacts of key-habitat loss, it is unclear how such changes will influence ice-associated marine mammals in part because of the logistical difficulties of studying foraging behaviour or other aspects of the ecology of large, mobile animals at sea during the polar winter. This study investigated the diet of pregnant bearded seals (Erignathus barbatus) during three spring breeding periods (2005, 2006 and 2007) with markedly contrasting ice conditions in Svalbard using stable isotopes (δ(13)C and δ(15)N) measured in whiskers collected from their newborn pups. The δ(15)N values in the whiskers of individual seals ranged from 11.95 to 17.45 ‰, spanning almost 2 full trophic levels. Some seals were clearly dietary specialists, despite the species being characterised overall as a generalist predator. This may buffer bearded seal populations from the changes in prey distributions lower in the marine food web which seems to accompany continued changes in temperature and ice cover. Comparisons with isotopic signatures of known prey, suggested that benthic gastropods and decapods were the most common prey. Bayesian isotopic mixing models indicated that diet varied considerably among years. In the year with most fast-ice (2005), the seals had the greatest proportion of pelagic fish and lowest benthic invertebrate content, and during the year with the least ice (2006), the seals ate more benthic invertebrates and less pelagic fish. This suggests that the seals fed further offshore in years with greater ice cover, but moved in to the fjords when ice-cover was minimal, giving them access to different types of prey. Long-term trends of sea ice decline, earlier ice melt, and increased water temperatures in the Arctic are likely to have ecosystem-wide effects, including impacts on the forage bases of pagophilic seals. PMID:22693616

  10. Main and Interactive Effects of Emotion Dysregulation and Breath-Holding Duration in Relation to Panic-Relevant Fear and Expectancies about Anxiety-Related Sensations among Adult Daily Smokers

    OpenAIRE

    Brandt, Charles P.; Johnson, Kirsten A.; Schmidt, Norman B.; Zvolensky, Michael J.

    2011-01-01

    The current study investigated the main and interactive effects of emotion dysregulation and distress tolerance in relation to panic-relevant variables among daily smokers. The sample consisted of 172 adults (61.2% male; Mage = 31.58, SD = 11.51), who reported smoking an average of 15.99 cigarettes per day (SD = 10.00). Results indicated that both emotion dysregulation and distress tolerance were significantly related to interoceptive fear and agoraphobia. Additionally, emotion dysregulation,...

  11. Contribution of Chronic Conditions to the Disability Burden across Smoking Categories in Middle-Aged Adults, Belgium

    Science.gov (United States)

    Yokota, Renata Tiene de Carvalho; Nusselder, Wilma Johanna; Robine, Jean-Marie; Tafforeau, Jean; Deboosere, Patrick; Van Oyen, Herman

    2016-01-01

    Introduction Smoking is considered the single most important preventable cause of morbidity and mortality worldwide, contributing to increased incidence and severity of disabling conditions. The aim of this study was to assess the contribution of chronic conditions to the disability burden across smoking categories in middle-aged adults in Belgium. Methods Data from 10,224 individuals aged 40 to 60 years who participated in the 1997, 2001, 2004, or 2008 Health Interview Surveys in Belgium were used. Smoking status was defined as never, former (cessation ≥2 years), former (cessation <2 years), occasional light (<20 cigarettes/day), daily light, and daily heavy (≥20 cigarettes/day). To attribute disability to chronic conditions, binomial additive hazards models were fitted separately for each smoking category adjusted for gender, except for former (cessation <2 years) and occasional light smokers due to the small sample size. Results An increasing trend in the disability prevalence was observed across smoking categories in men (never = 4.8%, former (cessation ≥2 years) = 5.8%, daily light = 7.8%, daily heavy = 10.7%) and women (never = 7.6%, former (cessation ≥2 years) = 8.0%, daily light = 10.2%, daily heavy = 12.0%). Musculoskeletal conditions showed a substantial contribution to the disability burden in men and women across all smoking categories. Other important contributors were depression and cardiovascular diseases in never smokers; depression, chronic respiratory diseases, and diabetes in former smokers (cessation ≥2 years); chronic respiratory diseases, cancer, and cardiovascular diseases in daily light smokers; cardiovascular diseases and chronic respiratory diseases in men and depression and diabetes in women daily heavy smokers. Conclusions Beyond the well-known effect of smoking on mortality, our findings showed an increasing trend of the disability prevalence and different contributors to the disability burden across smoking categories. This

  12. Chronic Conditions and Utility-Based Health-Related Quality of Life in Adult Childhood Cancer Survivors.

    Science.gov (United States)

    Yeh, Jennifer M; Hanmer, Janel; Ward, Zachary J; Leisenring, Wendy M; Armstrong, Gregory T; Hudson, Melissa M; Stovall, Marilyn; Robison, Leslie L; Oeffinger, Kevin C; Diller, Lisa

    2016-09-01

    Health utility, a summary measure of quality of life, has not been previously used to compare outcomes among childhood cancer survivors and individuals without a cancer history. We estimated health utility (0, death; 1, perfect health) using the Short Form-6D (SF-6D) in survivors (n = 7105) and siblings of survivors (n = 372) (using the Childhood Cancer Survivor Study cohort) and the general population (n = 12 803) (using the Medical Expenditures Panel Survey). Survivors had statistically significantly lower SF-6D scores than the general population (mean = 0.769, 95% confidence interval [CI] = 0.766 to 0.771, vs mean = 0.809, 95% CI = 0.806 to 0.813, respectively, ITALIC! PYoung adult survivors (age 18-29 years) reported scores comparable with general population estimates for people age 40 to 49 years. Among survivors, SF-6D scores were largely determined by number and severity of chronic conditions. No clinically meaningful differences were identified between siblings and the general population (mean = 0.793, 95% CI = 0.782 to 0.805, vs mean = 0.809, 95% CI = 0.806 to 0.813, respectively). This analysis illustrates the importance of chronic conditions on long-term survivor quality of life and provides encouraging results on sibling well-being. Preference-based utilities are informative tools for outcomes research in cancer survivors. PMID:27102402

  13. 31 CFR 800.217 - Hold.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Hold. 800.217 Section 800.217 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF INVESTMENT... FOREIGN PERSONS Definitions § 800.217 Hold. The terms hold(s) and holding mean legal or...

  14. Potential therapeutic competition in community-living older adults in the U.S.: use of medications that may adversely affect a coexisting condition.

    Directory of Open Access Journals (Sweden)

    Songprod Jonathan Lorgunpai

    Full Text Available OBJECTIVE: The 75% of older adults with multiple chronic conditions are at risk of therapeutic competition (i.e. treatment for one condition may adversely affect a coexisting condition. The objective was to determine the prevalence of potential therapeutic competition in community-living older adults. METHODS: Cross-sectional descriptive study of a representative sample of 5,815 community-living adults 65 and older in the U.S, enrolled 2007-2009. The 14 most common chronic conditions treated with at least one medication were ascertained from Medicare claims. Medication classes recommended in national disease guidelines for these conditions and used by ≥ 2% of participants were identified from in-person interviews conducted 2008-2010. Criteria for potential therapeutic competition included: 1, well-acknowledged adverse medication effect; 2 mention in disease guidelines; or 3 report in a systematic review or two studies published since 2000. Outcomes included prevalence of situations of potential therapeutic competition and frequency of use of the medication in individuals with and without the competing condition. RESULTS: Of 27 medication classes, 15 (55.5% recommended for one study condition may adversely affect other study conditions. Among 91 possible pairs of study chronic conditions, 25 (27.5% have at least one potential therapeutic competition. Among participants, 1,313 (22.6% received at least one medication that may worsen a coexisting condition; 753 (13% had multiple pairs of such competing conditions. For example, among 846 participants with hypertension and COPD, 16.2% used a nonselective beta-blocker. In only 6 of 37 cases (16.2% of potential therapeutic competition were those with the competing condition less likely to receive the medication than those without the competing condition. CONCLUSIONS: One fifth of older Americans receive medications that may adversely affect coexisting conditions. Determining clinical outcomes in these

  15. The Parent Control in the Mechanical Engineering Management-Holding

    Science.gov (United States)

    Šnircová, Jana; Hodulíková, Petra; Joehnk, Peter

    2012-12-01

    The group of entities under the control of parent, so called holding, is arisen as the result and the most often used form of the business concentration nowadays. The paper is focused to find special tasks of parent company for to preserve effective unified economic control in the management-holding. The unified economic control the holding exists in the conditions of the main conflict of interest - holding is not a legal but economic unit and the connected companies into it have a legal autonomy with the economic dependence. The unified economic control limits the financial independence of every individual company of the holding. The attention in the paper is concentrated to the management concept of the parent control, i.e. the parent company supervises the control of intragroup flows and all of subsidiaries production activities.

  16. Income level and chronic ambulatory care sensitive conditions in adults: a multicity population-based study in Italy

    Directory of Open Access Journals (Sweden)

    Forastiere Francesco

    2009-12-01

    Full Text Available Abstract Background A relationship between quality of primary health care and preventable hospitalizations has been described in the US, especially among the elderly. In Europe, there has been a recent increase in the evaluation of Ambulatory Care Sensitive Conditions (ACSC as an indicator of health care quality, but evidence is still limited. The aim of this study was to determine whether income level is associated with higher hospitalization rates for ACSC in adults in a country with universal health care coverage. Methods From the hospital registries in four Italian cities (Turin, Milan, Bologna, Rome, we identified 9384 hospital admissions for six chronic conditions (diabetes, hypertension, congestive heart failure, angina pectoris, chronic obstructive pulmonary disease, and asthma among 20-64 year-olds in 2000. Case definition was based on the ICD-9-CM coding algorithm suggested by the Agency for Health Research and Quality - Prevention Quality Indicators. An area-based (census block income index was used for each individual. All hospitalization rates were directly standardised for gender and age using the Italian population. Poisson regression analysis was performed to assess the relationship between income level (quintiles and hospitalization rates (RR, 95% CI separately for the selected conditions controlling for age, gender and city of residence. Results Overall, the ACSC age-standardized rate was 26.1 per 10.000 inhabitants. All conditions showed a statistically significant socioeconomic gradient, with low income people being more likely to be hospitalized than their well off counterparts. The association was particularly strong for chronic obstructive pulmonary disease (level V low income vs. level I high income RR = 4.23 95%CI 3.37-5.31 and for congestive heart failure (RR = 3.78, 95% CI = 3.09-4.62. With the exception of asthma, males were more vulnerable to ACSC hospitalizations than females. The risks were higher among 45-64 year

  17. Chronic conditions and sleep problems among adults aged 50 years or over in nine countries: a multi-country study 

    OpenAIRE

    Koyanagi, Ai; Garin, Noe; Olaya, Beatriz; Ayuso-Mateos, Jose Luis; Chatterji, Somnath; Leonardi, Matilde; Koskinen, Seppo; Tobiasz-Adamczyk, Beata; Haro, Josep Maria

    2014-01-01

    BACKGROUND: Data on the association between chronic conditions or the number of chronic conditions and sleep problems in low- or middle-income countries is scarce, and global comparisons of these associations with high-income countries have not been conducted. METHODS: Data on 42116 individuals 50 years and older from nationally-representative samples of the Collaborative Research on Ageing in Europe (Finland, Poland, Spain) and the World Health Organization's Study on Global Ageing and Adult...

  18. THE INERT HOLDING RATIO OF COAL ANDTHE STRENGTH OF COKE

    Institute of Scientific and Technical Information of China (English)

    陈鹏

    1996-01-01

    The variation regularity of coke strength was investigated in terms of the genetic fac-tors and petrographic parameters of coal in collaboration with the technical properties of coal. Aconcept of inert holding ratio of coal was proposed. There is an optimal inert holding ratio for dif-ferent ranks of coals for making coke with highest combined strength. The additive property of in-ert holding ratio under normal conditions was demonstrated with actual examples of coal blending.Thus it is possible to predict the combined strength of coke through reflectance, content of inertcomponents and caking index (Ro, max-I-G) diagram system.

  19. Blocking glucocorticoid receptors at adolescent age prevents enhanced freezing between repeated cue-exposures after conditioned fear in adult mice raised under chronic early life stress.

    Science.gov (United States)

    Arp, J Marit; Ter Horst, Judith P; Loi, Manila; den Blaauwen, Jan; Bangert, Eline; Fernández, Guillén; Joëls, Marian; Oitzl, Melly S; Krugers, Harm J

    2016-09-01

    Early life adversity can have long-lasting impact on learning and memory processes and increase the risk to develop stress-related psychopathologies later in life. In this study we investigated (i) how chronic early life stress (ELS) - elicited by limited nesting and bedding material from postnatal day 2 to 9 - affects conditioned fear in adult mice and (ii) whether these effects can be prevented by blocking glucocorticoid receptors (GRs) at adolescent age. In adult male and female mice, ELS did not affect freezing behavior to the first tone 24h after training in an auditory fear-conditioning paradigm. Exposure to repeated tones 24h after training also resulted in comparable freezing behavior in ELS and control mice, both in males and females. However, male (but not female) ELS compared to control mice showed significantly more freezing behavior between the tone-exposures, i.e. during the cue-off periods. Intraperitoneal administration of the GR antagonist RU38486 during adolescence (on postnatal days 28-30) fully prevented enhanced freezing behavior during the cue-off period in adult ELS males. Western blot analysis revealed no effects of ELS on hippocampal expression of glucocorticoid receptors, neither at postnatal day 28 nor at adult age, when mice were behaviorally tested. We conclude that ELS enhances freezing behavior in adult mice in a potentially safe context after cue-exposure, which can be normalized by brief blockade of glucocorticoid receptors during the critical developmental window of adolescence. PMID:27246249

  20. SPECIALIZATION AND SUSTAINABLE DEVELOPMENT OF AGRICULTURAL HOLDINGS

    Directory of Open Access Journals (Sweden)

    Zofia Kołoszko-Chomentowska

    2016-03-01

    Full Text Available In the present article, an attempt was made to assess the sustainability of agricultural holdings with diff erent directions of production. Agricultural holdings in the Podlaskie voivodeship registered in the FADN system in 2011–2012 were investigated. Assessment accounted for agroecological indicators (share of permanent grasslands, share of cereals in crops, soil coverage with vegetation, stock density and economic indicators (profi tableness of land and labor. Analysis was conducted according to a classifi cation into agricultural holding types: fi eldcrops, dairy cattle, and granivores. Fieldcrop and granivore holdings achieved more favourable environmental sustainability indicators. Holdings specializing in dairy cattle breeding posed a threat to the natural environment, mainly due to their excessive stock density. Economic sustainability assessment showed that granivore holdings were assessed most favorably. In these holdings, holding income per full-time worker was 37% greater than in fi eldcrop holdings and 57% greater than in dairy cattle holdings.

  1. China Rare Earth Holdings Limited

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    China Rare Earth Holdings Limited is a large trans-area corporation and a public company listed in Hong Kong Stock Exchange (Name: China Rare Earth, Code: 0769), with headquarter in Hong Kong. Located on the bank of beautiful Taihu Lake, the subsidiary in Yinxing covers area of 200,000 m2. It has nearly 1,000 employees, 30% of whom are technical staffs. After self-administration and effort, the company passed ISO 9001: 2000 and ISO 14000 Certificaitons.

  2. Transparency and International Portfolio Holdings

    OpenAIRE

    Gelos, Gaston; Wei, Shang-Jin

    2004-01-01

    Does country transparency affect international portfolio investment? We examine this question by constructing new measures of transparency and by making use of a unique micro dataset on portfolio holdings of emerging market funds around the world. We distinguish between government and corporate transparency. There is clear evidence that funds invest systematically less in less transparent countries. There is also some evidence that during crises, funds flee from non-transparent countries to a...

  3. Goedel's Incompleteness Theorems hold vacuously

    OpenAIRE

    Anand, Bhupinder Singh

    2002-01-01

    In an earlier paper, "Omega-inconsistency in Goedel's formal system: a constructive proof of the Entscheidungsproblem" (math/0206302), I argued that a constructive interpretation of Goedel's reasoning establishes any formal system of Arithmetic as omega-inconsistent. It follows from this that Goedel's Theorem VI holds vacuously. In this paper I show that Goedel's Theorem XI essentially states that, if we assume there is a P-formula [Con(P)] whose standard interpretation is equivalent to the a...

  4. Hormone responsiveness of cultured Sertoli cells obtained from adult rats after their rapid isolation under less harsh conditions.

    Science.gov (United States)

    Gautam, M; Bhattacharya, I; Devi, Y S; Arya, S P; Majumdar, S S

    2016-05-01

    During adulthood, testicular Sertoli cells (Sc) coordinate all stages of germ cell (Gc) development involved in sperm production. However, our understanding about the functions of adult Sc is limited because of the difficulties involved in the process of isolating these cells from the adult testis, mainly because of the presence of large number of advanced Gc which interfere with Sc isolation at this age. Most of our knowledge about Sc function are derived from studies which used pre-pubertal rat Sc (18 ± 2-day old) as it is easy to isolate and culture Sc at this age. To this end, we established a less time consuming and less harsh procedure of isolating Sc from adult (60 days of age) rat testis for facilitating research on Sc-mediated regulation of spermatogenesis during adulthood. The cells were isolated using collagenase digestion at higher temperature, reducing the exposure time of cells to the enzyme. Step-wise digestion with intermittent removal of small clusters of tissue helped in increasing the yield of Sc. Isolated Sc were cultured and treated with FSH and testosterone (T) to evaluate their hormone responsiveness in terms of lactate, E2 , cAMP production. Adult Sc were found to be active and produced high amounts of lactate in a FSH-independent manner. FSH-mediated augmentation of cAMP and E2 production by adult Sc was less as compared with that by pre-pubertal Sc obtained from 18-day-old rats. Androgen-binding ability of adult Sc was significantly higher than pre-pubertal Sc. Although T treatment remarkably augmented expression of Claudin 11, it failed to augment lactate production by adult Sc. This efficient and rapid procedure for isolation and culture of functionally viable adult rat Sertoli cells may pave the way for determining their role in regulation and maintenance of spermatogenesis. PMID:26991307

  5. Does combined cognitive training and physical activity training enhance cognitive abilities more than either alone? A four-condition randomized controlled trial among healthy older adults

    Directory of Open Access Journals (Sweden)

    Evelyn eShatil

    2013-03-01

    Full Text Available Cognitive training and aerobic training are known to improve cognitive functions. To examine the separate and combined effects of such training on cognitive performance, four groups of healthy older adults embarked on a four months cognitive and/or mild aerobic training. A first group (n=33, mean age=80 [66-90] engaged in cognitive training, a second (n=29, mean age=81 [65-89] in mild aerobic training, a third (n=29, mean age=79 [70-93] in the combination of both and a fourth (n=31, mean age=79 [71-92] control group engaged in book-reading activity. The outcome was a well validated multi-domain computerized cognitive evaluation for older adults. The results indicate that, when compared to older adults who did not engage in cognitive training (the mild aerobic and control groups older adults who engaged in cognitive training (separate or combined training groups showed significant improvement in cognitive performance on Hand-Eye Coordination, Global Visual Memory (working memory and long-term memory, Speed of Information Processing, Visual Scanning and Naming. Indeed, individuals who did not engage in cognitive training showed no such improvements. Those results suggest that cognitive training is effective in improving cognitive performance and that it (and not mild aerobic training is driving the improvement in the combined condition. Results are discussed in terms of the special circumstances of aerobic and cognitive training for older adults who are above 80 years of age.

  6. Do More Economists Hold Stocks?

    DEFF Research Database (Denmark)

    Christiansen, Charlotte; Joensen, Juanna Schröter; Rangvid, Jesper

    , even when controlling for several background characteristics. We make use of a large register-based panel data set containing detailed information on the educational attainments and various financial and socioeconomic variables. We model the stock market participation decision by the probit model. The......A unique data set enables us to test the hypothesis that more economists than otherwise identical investors hold stocks due to informational advantages. We confirm that economists have a significantly higher probability of participating in the stock market than investors with any other education...

  7. Allowance Holdings and Transfers Data Inventory

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Allowance Holdings and Transfers Data Inventory contains measured data on holdings and transactions of allowances under the NOx Budget Trading Program (NBP), a...

  8. Seeking Conditions of Possibility: (Re)conceptualising Democratic Discursive Practices in a Rights-Based Approach to Adult Education

    Science.gov (United States)

    Chopra, Priti

    2014-01-01

    This paper draws on ethnographic vignettes in an Indian rights-based approach to adult education programmes in order to examine the contestations and negotiations of facilitators in interface situations involving programme capacity building, monitoring and evaluation practice. The paper proposes that making visible the hegemonic nature of…

  9. Demographic Characteristics, Health Conditions, and Residential Service Use in Adults with Down Syndrome in 25 U.S. States

    Science.gov (United States)

    Stancliffe, Roger J.; Lakin, K. Charlie; Larson, Sheryl A.; Engler, Joshua; Taub, Sarah; Fortune, Jon; Bershadsky, Julie

    2012-01-01

    This study describes service users with Down syndrome (N = 1,199) and a comparative sample with intellectual and developmental disabilities but not Down syndrome (N = 11,182), drawn from National Core Indicator surveys of adult service users in 25 U.S. states. Individuals with Down syndrome were younger than were individuals without Down syndrome.…

  10. Ultrasonic methods for locating hold-up

    International Nuclear Information System (INIS)

    Hold-up remains one of the major contributing factors to unaccounted for materials and can be a costly problem in decontamination and decommissioning activities. Ultrasonic techniques are being developed to noninvasively monitor hold-up in process equipment where the inner surface of such equipment may be in contact with the hold-up material. These techniques may be useful in improving hold-up measurements as well as optimizing decontamination techniques

  11. A description of medical conditions in adults with autism spectrum disorder: A follow-up of the 1980s Utah/UCLA Autism Epidemiologic Study.

    Science.gov (United States)

    Jones, Kyle B; Cottle, Kristina; Bakian, Amanda; Farley, Megan; Bilder, Deborah; Coon, Hilary; McMahon, William M

    2016-07-01

    This study describes medical conditions experienced by a population-based cohort of adults with autism spectrum disorder whose significant developmental concerns were apparent during childhood. As part of a 25-year outcome study of autism spectrum disorder in adulthood, medical histories were collected on 92 participants (N = 69 males) who were first ascertained as children in the mid-1980s, 11 of whom were deceased at the time of follow-up. Questionnaires queried medical symptoms, disorders, hospitalizations, surgeries, and medication use. Median age at follow-up was 36 years (range: 23.5-50.5 years), and intellectual disability co-occurred in 62%. The most common medical conditions were seizures, obesity, insomnia, and constipation. The median number of medical conditions per person was 11. Increased medical comorbidity was associated with female gender (p = 0.01) and obesity (p = 0.03), but not intellectual disability (p = 0.79). Adults in this cohort of autism spectrum disorder first ascertained in the 1980s experience a high number of chronic medical conditions, regardless of intellectual ability. Understanding of these conditions commonly experienced should direct community-based and medical primary care for this population. PMID:26162628

  12. The effect of a cognitive-motor intervention on voluntary step execution under single and dual task conditions in older adults: a randomized controlled pilot study

    Directory of Open Access Journals (Sweden)

    Pichierri G

    2012-07-01

    Full Text Available Giuseppe Pichierri,1 Amos Coppe,1 Silvio Lorenzetti,2 Kurt Murer,1 Eling D de Bruin11Institute of Human Movement Sciences and Sport, Department of Health Sciences and Technology, ETH Zurich, Switzerland; 2Institute for Biomechanics, Department of Health Sciences and Technology, ETH Zurich, SwitzerlandBackground: This randomized controlled pilot study aimed to explore whether a cognitive-motor exercise program that combines traditional physical exercise with dance video gaming can improve the voluntary stepping responses of older adults under attention demanding dual task conditions.Methods: Elderly subjects received twice weekly cognitive-motor exercise that included progressive strength and balance training supplemented by dance video gaming for 12 weeks (intervention group. The control group received no specific intervention. Voluntary step execution under single and dual task conditions was recorded at baseline and post intervention (Week 12.Results: After intervention between-group comparison revealed significant differences for initiation time of forward steps under dual task conditions (U = 9, P = 0.034, r = 0.55 and backward steps under dual task conditions (U = 10, P = 0.045, r = 0.52 in favor of the intervention group, showing altered stepping levels in the intervention group compared to the control group.Conclusion: A cognitive-motor intervention based on strength and balance exercises with additional dance video gaming is able to improve voluntary step execution under both single and dual task conditions in older adults.Keywords: fall prevention, exercise, dance, video game

  13. Phase-Type Models of Channel-Holding Times in Cellular Communication Systems

    DEFF Research Database (Denmark)

    Christensen, Thomas Kaare; Nielsen, Bo Friis; Iversen, Villy Bæk

    2004-01-01

    In this paper, we derive the distribution of the channel-holding time when both cell-residence and call-holding times are phase-type distributed. Furthermore, the distribution of the number of handovers, the conditional channel-holding time distributions, and the channel-holding time when cell re...... residence times are correlated are derived. All distributions are of phase type, making them very general and flexible. The channel-holding times are of importance in performance evaluation and simulation of cellular mobile communication systems....

  14. 7 CFR 984.33 - Hold.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Hold. 984.33 Section 984.33 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Handling Definitions § 984.33 Hold. Hold means to maintain possession or keep control of, in proper...

  15. 76 FR 36625 - Mutual Holding Company

    Science.gov (United States)

    2011-06-22

    ... Office of Thrift Supervision Mutual Holding Company AGENCY: Office of Thrift Supervision (OTS), Treasury... collection. Title of Proposal: Mutual Holding Company. OMB Number: 1550-0072. Form Numbers: MHC-1 (OTS Form... whether the applicant meets the statutory and regulatory criteria to form a mutual holding company...

  16. 76 FR 20458 - Mutual Holding Company

    Science.gov (United States)

    2011-04-12

    ... Office of Thrift Supervision Mutual Holding Company AGENCY: Office of Thrift Supervision (OTS), Treasury... collection. Title of Proposal: Mutual Holding Company. OMB Number: 1550-0072. Form Numbers: MHC-1 (OTS Form... whether the applicant meets the statutory and regulatory criteria to form a mutual holding company...

  17. A series of abnormal climatic conditions caused the most severe outbreak of first-generation adults of the meadow moth ( Loxostege sticticalis L.) in China

    Science.gov (United States)

    Chen, Xiao; Zeng, Juan; Zhai, Baoping

    2016-06-01

    The meadow moth, Loxostege sticticalis L., is a destructive migratory pest in the northern temperate zone. The outbreak mechanism of first-generation adults in China remains unclear. In 2008, the density of first-generation larvae was very low or even negligible in most sites in China. However, a great number of first-generation adults appeared unexpectedly in late July, and their offspring caused the most severe infestation on record. The present study aims to determine where the large influx of immigrant adults originated from and how this unprecedented population was established. Source areas were explored by trajectory analysis, and climatic patterns related to the population increase were investigated. Results showed that the outbreak population mainly immigrated from Northeast Mongolia and the Chita State of Russia, and the buildup of such a large population could be attributed to an exceptional northward migration of overwintered adults from North China to East Mongolia in the spring of 2007 and unusually favourable climatic conditions in the next two growth seasons. These results indicated that the population dynamics of meadow moth in Northeast Asia would be difficult to predict when only considering local climatic factors and population size within one country. International joint monitoring and information sharing related to this pest between China, Mongolia and Russia should be implemented.

  18. Role of physical activity, physical fitness, and chronic health conditions on the physical independence of community-dwelling older adults over a 5-year period.

    Science.gov (United States)

    Pereira, Catarina; Baptista, Fátima; Cruz-Ferreira, Ana

    2016-01-01

    The variability in the individual characteristics and habits could help determine how older adults maintain independence. The impact of the variability in physical activity, physical fitness, body composition, and chronic health conditions (co-morbidities) on the independence of older adults, especially over time, is seldom examined. This study aims to analyze quantitatively the impact of baseline values and changes in physical activity, physical fitness, body composition, and co-morbidities on the physical independence of community-dwelling, older adults over a 5-year period. Data from 106 and 85 community-dwelling adults (≥60 years) were collected at baseline and after five years, respectively. Linear regression selected the main predictors of changes in physical independence as follows: the baseline physical independence (β=0.032, R(2)=9.9%) and co-morbidities (β=-0.191, R(2)=6.3%) and the changes in co-morbidities (β=-0.244, R(2)=10.8%), agility (β=-0.288, R(2)=6.7%), aerobic endurance (β=0.007, R(2)=3.2%), and walking expenditure (β=0.001, R(2)=5.1%) (pindependence, baseline co-morbidities, and changes in co-morbidities, walking, agility, and aerobic endurance predicted physical independence over five years regardless of age and gender. Gains of up to 8.3% in physical independence were associated with improvements in these variables, which corresponds to regaining independence for performing one or two activities of daily living. PMID:26966842

  19. A series of abnormal climatic conditions caused the most severe outbreak of first-generation adults of the meadow moth (Loxostege sticticalis L.) in China

    Science.gov (United States)

    Chen, Xiao; Zeng, Juan; Zhai, Baoping

    2015-10-01

    The meadow moth, Loxostege sticticalis L., is a destructive migratory pest in the northern temperate zone. The outbreak mechanism of first-generation adults in China remains unclear. In 2008, the density of first-generation larvae was very low or even negligible in most sites in China. However, a great number of first-generation adults appeared unexpectedly in late July, and their offspring caused the most severe infestation on record. The present study aims to determine where the large influx of immigrant adults originated from and how this unprecedented population was established. Source areas were explored by trajectory analysis, and climatic patterns related to the population increase were investigated. Results showed that the outbreak population mainly immigrated from Northeast Mongolia and the Chita State of Russia, and the buildup of such a large population could be attributed to an exceptional northward migration of overwintered adults from North China to East Mongolia in the spring of 2007 and unusually favourable climatic conditions in the next two growth seasons. These results indicated that the population dynamics of meadow moth in Northeast Asia would be difficult to predict when only considering local climatic factors and population size within one country. International joint monitoring and information sharing related to this pest between China, Mongolia and Russia should be implemented.

  20. Auditory training can improve working memory, attention, and communication in adverse conditions for adults with hearing loss

    OpenAIRE

    Ferguson, Melanie A.; Henshaw, Helen

    2015-01-01

    Auditory training (AT) helps compensate for degradation in the auditory signal. A series of three high-quality training studies are discussed, which include, (i) a randomized controlled trial (RCT) of phoneme discrimination in quiet that trained adults with mild hearing loss (n = 44), (ii) a repeated measures study that trained phoneme discrimination in noise in hearing aid (HA) users (n = 30), and (iii) a double-blind RCT that directly trained working memory (WM) in HA users (n = 57). AT res...

  1. Auditory training can improve working memory, attention and communication in adverse conditions for adults with hearing loss

    OpenAIRE

    Melanie Ann Ferguson; Helen eHenshaw

    2015-01-01

    Auditory training (AT) helps compensate for degradation in the auditory signal. A series of three high-quality training studies are discussed, (i) a randomized controlled trial (RCT) of phoneme discrimination in quiet that trained adults with mild hearing loss (n=44), (ii) a repeated measures study that trained phoneme discrimination in noise in hearing aid (HA) users (n=30), and (iii) a double-blind RCT that directly trained working memory (WM) in HA users (n=57). AT resulted in generalized ...

  2. Survival and weight change among adult individuals of Periplaneta americana (Linnaeus, 1758) (Blattaria, Blattidae) subject to various stress conditions

    OpenAIRE

    Jucelio Peter Duarte; Francielly Felchicher; Paulo Bretanha Ribeiro; Marcial Corrêa Cárcamo

    2015-01-01

    Periplaneta americana is a species of great importance to public health, since it can act as a vector of many pathogens and it reaches large populations in urban environments. This is probably due to its ability to resist starvation and desiccation. This study aimed to evaluate the effects of absence of water and food on survival and weight change among adult P. americana individuals and check whether the initial weight of individuals influences on their survival. Four groups having twenty P....

  3. Chemical immobilization of adult female Weddell seals with tiletamine and zolazepam: effects of age, condition and stage of lactation

    OpenAIRE

    Harcourt Robert G; Bradshaw Corey JA; Wheatley Kathryn E; Davis Lloyd S; Hindell Mark A

    2006-01-01

    Abstract Background Chemical immobilization of Weddell seals (Leptonychotes weddellii) has previously been, for the most part, problematic and this has been mainly attributed to the type of immobilizing agent used. In addition to individual sensitivity, physiological status may play an important role. We investigated the use of the intravenous administration of a 1:1 mixture of tiletamine and zolazepam (Telazol®) to immobilize adult females at different points during a physiologically demandi...

  4. Water holding capacity and swelling of casein hydrogels

    NARCIS (Netherlands)

    de Kruif, C; Anema, Skelte G.; Zhu, Changjun; Havea, Palatasa; Coker, Christina

    2015-01-01

    The water holding capacity of casein gels was investigated by measuring the swelling and de-swelling under a variety of conditions of temperature and salt concentration. Transglutaminase cross-linked sodium caseinate (15% w/w) gels will swell in good solvents or shrink in poor solvents until an equi

  5. Adolescent Social Defeat Induced Alterations in Social Behavior and Cognitive Flexibility in Adult Mice: Effects of Developmental Stage and Social Condition

    Science.gov (United States)

    Zhang, Fan; Yuan, Sanna; Shao, Feng; Wang, Weiwen

    2016-01-01

    Negative social experiences during adolescence increase the risk of psychiatric disorders in adulthood. Using “resident-intruder” stress, the present study aimed to investigate the effects of adolescent social defeat on emotional and cognitive symptoms associated with psychiatric disorders during adulthood and the effects of the developmental stage and social condition on this process. In Experiment 1, animals were exposed to social defeat or manipulation for 10 days during early adolescence (EA, postnatal days [PND] 28–37), late adolescence (LA, PND 38–47), and adulthood (ADULT, PND 70–79) and then singly housed until the behavioral tests. Behaviors, including social avoidance of the defeat context and cortically mediated cognitive flexibility in an attentional set-shifting task (AST), were assessed during the week following stress or after 6 weeks during adulthood. We determined that social defeat induced significant and continuous social avoidance across age groups at both time points. The mice that experienced social defeat during adulthood exhibited short-term impairments in reversal learning (RL) on the AST that dissipated after 6 weeks. In contrast, social defeat during EA but not LA induced a delayed deficit in extra-dimensional set-shifting (EDS) in adulthood but not during adolescence. In Experiment 2, we further examined the effects of social condition (isolation or social housing after stress) on the alterations induced by social defeat during EA in adult mice. The adult mice that had experienced stress during EA exhibited social avoidance similar to the avoidance identified in Experiment 1 regardless of the isolation or social housing after the stress. However, social housing after the stress ameliorated the cognitive flexibility deficits induced by early adolescent social defeat in the adult mice, and the social condition had no effect on cognitive function. These findings suggest that the effects of social defeat on emotion and cognitive

  6. Investasi: Komparasi Strategi Buy and Hold dengan Pendekatan Teknikal

    Directory of Open Access Journals (Sweden)

    Natica Ardani

    2012-01-01

    Full Text Available This research aims to analyse effectivity of technical analysis moving average compare to buy and hold strategy on index LQ-45 (as emerging market and S&P500 (as developed market. Using descriptive approach, this research analysed by metastock program with moving average exponential crossovers method. This research data samples use LQ45 and S&P500 from year 2001-2011. The findings of this research indicate that technical analysis more effective when economic situation on crisis (bearish. Whereas buy and hold strategy more effective on good economic condition (bullish. The results consistent for LQ-45 and S&P500.

  7. Auditory training can improve working memory, attention and communication in adverse conditions for adults with hearing loss

    Directory of Open Access Journals (Sweden)

    Melanie Ann Ferguson

    2015-05-01

    Full Text Available Auditory training (AT helps compensate for degradation in the auditory signal. A series of three high-quality training studies are discussed, (i a randomized controlled trial (RCT of phoneme discrimination in quiet that trained adults with mild hearing loss (n=44, (ii a repeated measures study that trained phoneme discrimination in noise in hearing aid (HA users (n=30, and (iii a double-blind RCT that directly trained working memory (WM in HA users (n=57. AT resulted in generalized improvements in measures of self-reported hearing, competing speech and complex cognitive tasks that all index executive functions. This suggests that for AT related benefits, the development of complex cognitive skills may be more important than the refinement of sensory processing. Furthermore, outcome measures should be sensitive to the functional benefits of auditory training. For WM training, lack of far-transfer to untrained outcomes suggests no generalized benefits to real-world listening abilities. We propose that combined auditory-cognitive training approaches, where cognitive enhancement is embedded within auditory tasks, are most likely to offer generalized benefits to the real-world listening abilities of adults with hearing loss.

  8. ALICE Holds Up to Challenge

    CERN Multimedia

    2006-01-01

    ALICE's main austenitic stainless steel support structure (the Space Frame) has recently gone through many tests that proved quite challenging: insuring the structure is sound and lowering it horizontally into the ALICE cavern. This structure is constructed to hold the large volume detectors, such as the Time Projection Chamber, Transition Radiation Detector and Time of Flight inside the ALICE solenoid magnet. After the final assembly at CERN, two large mobile cranes were needed for the job of lifting and turning the 14 tonne frame onto its side. Once shifted, it was placed in Building SX2, one of the surface assembly areas designated for ALICE. The structure, which is 8 m in diameter and 7 m long, underwent many tests in its new position. Geometric control tests were performed by measuring each of the 18 cells and placing wooden or metal samples constructed to the same dimensions as the real thing inside the structure. The most important check was the movement of the real Time Projection Chamber from its s...

  9. Corporate Cash Holdings, National Culture, and Multinationality

    OpenAIRE

    Andres Ramirez; Solomon Tadesse

    2007-01-01

    We examine the relations between national cultures, the multinationality of the firm and its holdings of cash. We develop several hypotheses from well known corporate finance theories and theories of the multinational firm, positing that cultural factors as well as the degree of multinationality of firms influence their decisions to hold cash. In particular, firms in countries with high uncertainty avoidance, as a national culture, hold more cash as a way to hedge against undesired states of ...

  10. Feasibility Study of Regenerative Burners in Aluminum Holding Furnaces

    Science.gov (United States)

    Hassan, Mohamed I.; Al Kindi, Rashid

    2014-09-01

    Gas-fired aluminum holding reverberatory furnaces are currently considered to be the lowest efficiency fossil fuel system. A considerable volume of gas is consumed to hold the molten metal at temperature that is much lower than the flame temperature. This will lead to more effort and energy consumption to capture the excessive production of the CO2. The concern of this study is to investigate the feasibility of the regenerative-burners' furnaces to increase the furnace efficiency to reduce gas consumption per production and hence result in less CO2 production. Energy assessments for metal holding furnaces are considered at different operation conditions. Onsite measurements, supervisory control and data acquisition data, and thermodynamics analysis are performed to provide feasible information about the gas consumption and CO2 production as well as area of improvements. In this study, onsite measurements are used with thermodynamics modeling to assess a 130 MT rectangular furnace with two regenerative burners and one cold-air holding burner. The assessment showed that the regenerative burner furnaces are not profitable in saving energy, in addition to the negative impact on the furnace life. However, reducing the holding and door opening time would significantly increase the operation efficiency and hence gain the benefit of the regenerative technology.

  11. Prescription Drug Use Among Adults With Chronic Conditions in South Korea: Dual Burden of Health Care Needs and Socioeconomic Vulnerability.

    Science.gov (United States)

    Jung, Youn; Byeon, Jinok; Chung, Haejoo

    2016-01-01

    The aim of this study is to identify the social determinants of prescription drug use among adults with chronic diseases by examining the associations between socioeconomic position and prescription medicine use and perceived burden for pharmaceutical expenditure, using a sample of the Korean population from the 2008 Korea Health Panel, with 4 analytic models. Controlled with health status and the type of health insurance, the probability of using prescription drugs and overall spending on drugs significantly increased with rising income level, while perceived burden for out-of-pocket payment significantly decreased. These results imply that the poor are likely to underuse prescription drugs compared with their wealthier counterparts with the same need for health care, probably due to economic barriers. PMID:26512028

  12. Prenatal alcohol exposure alters synaptic activity of adult hippocampal dentate granule cells under conditions of enriched environment.

    Science.gov (United States)

    Kajimoto, Kenta; Valenzuela, C Fernando; Allan, Andrea M; Ge, Shaoyu; Gu, Yan; Cunningham, Lee Anna

    2016-08-01

    Prenatal alcohol exposure (PAE) results in fetal alcohol spectrum disorder (FASD), which is characterized by a wide range of cognitive and behavioral deficits that may be linked to impaired hippocampal function and adult neurogenesis. Preclinical studies in mouse models of FASD indicate that PAE markedly attenuates enrichment-mediated increases in the number of adult-generated hippocampal dentate granule cells (aDGCs), but whether synaptic activity is also affected has not been studied. Here, we utilized retroviral birth-dating coupled with whole cell patch electrophysiological recordings to assess the effects of PAE on enrichment-mediated changes in excitatory and inhibitory synaptic activity as a function of DGC age. We found that exposure to an enriched environment (EE) had no effect on baseline synaptic activity of 4- or 8-week-old aDGCs from control mice, but significantly enhanced the excitatory/inhibitory ratio of synaptic activity in 8-week-old aDGCs from PAE mice. In contrast, exposure to EE significantly enhanced the excitatory/inhibitory ratio of synaptic activity in older pre-existing DGCs situated in the outer dentate granule cell layer (i.e., those generated during embryonic development; dDGCs) in control mice, an effect that was blunted in PAE mice. These findings indicate distinct electrophysiological responses of hippocampal DGCs to behavioral challenge based on cellular ontogenetic age, and suggest that PAE disrupts EE-mediated changes in overall hippocampal network activity. These findings may have implications for future therapeutic targeting of hippocampal dentate circuitry in clinical FASD. © 2016 Wiley Periodicals, Inc. PMID:27009742

  13. Increased adult hippocampal neurogenesis is not necessary for wheel running to abolish conditioned place preference for cocaine in mice

    OpenAIRE

    Mustroph, M.L.; Merritt, J R; Holloway, A.L.; Pinardo, H.; Miller, D S; Kilby, C.N.; Bucko, P.; Wyer, A.; Rhodes, J S

    2014-01-01

    Recent evidence suggests wheel running can abolish conditioned place preference (CPP) for cocaine in mice. Running significantly increases the number of new neurons in the hippocampus, and new neurons have been hypothesized to enhance plasticity and behavioral flexibility. Therefore, we tested the hypothesis that increased neurogenesis was necessary for exercise to abolish cocaine CPP. Male nestin thymidine kinase transgenic mice were conditioned with cocaine, and then housed with or without ...

  14. Outdoor air pollution, meteorological conditions and indoor factors in dwellings in relation to sick building syndrome (SBS) among adults in China.

    Science.gov (United States)

    Lu, Chan; Deng, Qihong; Li, Yuguo; Sundell, Jan; Norbäck, Dan

    2016-08-01

    Indoor environment is associated with the sick building syndrome (SBS), but little is known about the contribution of outdoor air pollution and meteorological conditions to SBS. We studied associations between outdoor air pollution, meteorological parameters and selected indoor exposure and building characteristics at home and weekly SBS symptoms in a standardized questionnaire study among 3485 randomly selected adults in China. Outdoor factors included particulate matters with diameter bathroom reduced dermal symptoms OR=0.66 (0.44-0.99). Females were more susceptible to redecoration and window pane condensation than men. No associations with SBS were observed for outdoor air pollutants or meteorological parameters in the final models combining indoor and outdoor factors, although SO2, T, and RH were associated with some SBS symptoms (fatigue, eyes and nose symptoms) in the separate outdoor models. In conclusion, indoor mold/dampness, air pollution from redecoration and poorer ventilation conditions in dwellings can be risk factors for SBS symptoms in an adult Chinese population, especially among females. PMID:27101454

  15. Holding equine oocytes in a commercial embryo-holding medium: New perspective on holding temperature and maturation time.

    Science.gov (United States)

    Dini, Pouya; Bogado Pascottini, Osvaldo; Ducheyne, Kaatje; Hostens, Miel; Daels, Peter

    2016-09-15

    In the present study, we examined the effect of holding equine oocytes in Syngro embryo holding medium (EHM) overnight at either 4 °C, 17 °C, or 22 °C to 25 °C, on the time to maturation and developmental competence. We also examined the effect of placing denuded oocyte without extruded polar body back in maturation condition on subsequent maturation rate. In experiment 1, cumulus-oocyte complexes (COCs) were recovered postmortem and placed in EHM at 22 °C to 25 °C for 18 to 20 hours (OH) or placed directly in maturation (DM). The maturation rate was assessed after 22, 24, or 28 hours of culture. After denuding cumulus cells at 22 or 24 hours, oocytes without obvious polar body were placed back into culture and reassessed at subsequent time points. At 22 hours, a higher proportion of oocytes placed in OH achieved nuclear maturation than those placed in DM (63% and 37%, respectively, P = 0.008). At 24 and 28 hours, no significant differences in the % MII stage oocytes were observed between OH and DM. The nuclear maturation rate for OH oocytes was similar at 22, 24, and 28 hours, indicating that the maximum maturation rate was reached at an earlier time than that in DM. Oocytes fertilized by intracytoplasmic sperm injection resulted in a 7.1% and 6.3% blastocyst rate for OH and DM, respectively. Denuding oocytes after 22 hours or more of culture did not have an adverse effect on the final nuclear maturation rate. After 28 hours of culture, the same nuclear maturation rate (MII) was reached for nondenuded oocytes and oocytes denuded after 22 hours of 24 hours of culture. In experiment 2, COCs were held overnight at room temperature in EHM, then placed in maturation for 20, 22, and 28 hours. Nuclear maturation rate was significantly lower at 20 hours than 22 and 28 hours of culture and was similar at 22 and 28 hours, suggesting that at least 22 hours of culture is required to reach maximal maturation rate for stored oocytes (43%, 62%, and 65% at 20, 22

  16. Leucocytes in adult burrowing parrots in the wild: variation between contrasting breeding seasons, gender, and individual condition

    OpenAIRE

    Plischke, Andreas; Quillfeldt, Petra; Lubjuhn, Thomas; Merino, Santiago; Masello, Juan F.

    2009-01-01

    Abstract Wild birds exposed to stressors may modulate their investment in immunity. We studied the leucocytes of breeding burrowing parrots (Cyanoliseus patagonus) in Patagonia during five breeding seasons, during which global climate events such as a strong La Ni?a and a weak El Ni?o occurred. We observed strong inter-annual variation in the ratio of heterophils to lymphocytes (H/L), with higher H/L during the adverse conditions of La Ni?a compared with the favourable conditions o...

  17. NextGen Flight Deck Surface Trajectory-Based Operations (STBO): Contingency Holds

    Science.gov (United States)

    Bakowski, Deborah Lee; Hooey, Becky Lee; Foyle, David C.; Wolter, Cynthia A.; Cheng, Lara W. S.

    2013-01-01

    The purpose of this pilot-in-the-loop taxi simulation was to investigate a NextGen Surface Trajectory-Based Operations (STBO) concept called "contingency holds." The contingency-hold concept parses a taxi route into segments, allowing an air traffic control (ATC) surface traffic management (STM) system to hold an aircraft when necessary for safety. Under nominal conditions, if the intersection or active runway crossing is clear, the hold is removed, allowing the aircraft to continue taxiing without slowing, thus improving taxi efficiency, while minimizing the excessive brake use, fuel burn, and emissions associated with stop-and-go taxi. However, when a potential traffic conflict exists, the hold remains in place as a fail-safe mechanism. In this departure operations simulation, the taxi clearance included a required time of arrival (RTA) to a specified intersection. The flight deck was equipped with speed-guidance avionics to aid the pilot in safely meeting the RTA. On two trials, the contingency hold was not released, and pilots were required to stop. On two trials the contingency hold was released 15 sec prior to the RTA, and on two trials the contingency hold was released 30 sec prior to the RTA. When the hold remained in place, all pilots complied with the hold. Results also showed that when the hold was released at 15-sec or 30-sec prior to the RTA, the 30-sec release allowed pilots to maintain nominal taxi speed, thus supporting continuous traffic flow; whereas, the 15-sec release did not. The contingency-hold concept, with at least a 30-sec release, allows pilots to improve taxiing efficiency by reducing braking, slowing, and stopping, but still maintains safety in that no pilots "busted" the clearance holds. Overall, the evidence suggests that the contingency-hold concept is a viable concept for optimizing efficiency while maintaining safety.

  18. A cognitive-motor intervention using a dance video game to enhance foot placement accuracy and gait under dual task conditions in older adults: a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Pichierri Giuseppe

    2012-12-01

    Full Text Available Abstract Background Computer-based interventions have demonstrated consistent positive effects on various physical abilities in older adults. This study aims to compare two training groups that achieve similar amounts of strength and balance exercise where one group receives an intervention that includes additional dance video gaming. The aim is to investigate the different effects of the training programs on physical and psychological parameters in older adults. Methods Thirty-one participants (mean age ± SD: 86.2 ± 4.6 years, residents of two Swiss hostels for the aged, were randomly assigned to either the dance group (n = 15 or the control group (n = 16. The dance group absolved a twelve-week cognitive-motor exercise program twice weekly that comprised progressive strength and balance training supplemented with additional dance video gaming. The control group performed only the strength and balance exercises during this period. Outcome measures were foot placement accuracy, gait performance under single and dual task conditions, and falls efficacy. Results After the intervention between-group comparison revealed significant differences for gait velocity (U = 26, P = .041, r = .45 and for single support time (U = 24, P = .029, r = .48 during the fast walking dual task condition in favor of the dance group. No significant between-group differences were observed either in the foot placement accuracy test or in falls efficacy. Conclusions There was a significant interaction in favor of the dance video game group for improvements in step time. Significant improved fast walking performance under dual task conditions (velocity, double support time, step length was observed for the dance video game group only. These findings suggest that in older adults a cognitive-motor intervention may result in more improved gait under dual task conditions in comparison to a traditional strength and balance exercise program

  19. Sibling Status Effects: Adult Expectations.

    Science.gov (United States)

    Baskett, Linda Musun

    1985-01-01

    This study attempted to determine what expectations or beliefs adults might hold about a child based on his or her sibling status alone. Ratings on 50 adjective pairs for each of three sibling status types, only, oldest, and youngest child, were assessed in relation to adult expectations, birth order, and parental status of rater. (Author/DST)

  20. 78 FR 66097 - Acies Corporation, Immtech Pharmaceuticals, Inc., MRU Holdings, Inc., MSTI Holdings, Inc., Nestor...

    Science.gov (United States)

    2013-11-04

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Acies Corporation, Immtech Pharmaceuticals, Inc., MRU Holdings, Inc., MSTI Holdings, Inc., Nestor... there is a lack of current and accurate information concerning the securities of Immtech...

  1. The Engagement in Physical Activity for Middle-Aged and Older Adults with Multiple Chronic Conditions: Findings from a Community Health Assessment

    Directory of Open Access Journals (Sweden)

    Wei-Chen Lee

    2013-01-01

    Full Text Available The current aging trends accompanying the increasing prevalence of multiple chronic conditions (MCCs and decreasing participation in physical activity (PA have swept the United States. In light of the magnitude of this phenomenon, this study seeks to identify the most common MCC combinations and their relationships with PA level. A cross-sectional study, Brazos Valley Health Assessment, was conducted between October 2009 and July 2010. All data analyses were performed by STATA 12.0. The overall sample which met the inclusion criteria is 2,603. Among people older than 45 years, chronic conditions of cardiovascular, endocrine, and musculoskeletal systems were the most prevalent. Participants with three chronic conditions were less likely to meet the PA standard than those with only two chronic conditions. Younger age, women, rural residence, and unsafe environments were related to the lower PA level. After adjusting for seven covariates, all MCCs combinations adversely affect the level of PA (, . People with MCCs were among the least active subgroups despite the health benefits of doing exercise. Given the well-documented benefits of physical activity for delaying the onset or progression of MCCs, public health efforts to enhance regular PA in middle-aged and older adults are recommended.

  2. A randomized controlled trial of telemonitoring in older adults with multiple chronic conditions: the Tele-ERA study

    Directory of Open Access Journals (Sweden)

    Takahashi Paul Y

    2010-09-01

    Full Text Available Abstract Background Older adults with multiple chronic illnesses are at risk for worsening functional and medical status and hospitalization. Home telemonitoring may help slow this decline. This protocol of a randomized controlled trial was designed to help determine the impact of home telemonitoring on hospitalization. The specific aim of the study reads as follows: to determine the effectiveness of home telemonitoring compared with usual care in reducing the combined outcomes of hospitalization and emergency department visits in an at-risk population 60 years of age or older. Methods/Design Two-hundred patients with the highest 10% Mayo Clinic Elder Risk Assessment scores will be randomly assigned to one of two interventions. Home telemonitoring involves the use of a computer device, the Intel Health Guide, which records biometric and symptom data from patients in their homes. This information is monitored by midlevel providers associated with a primary care medical practice. Under the usual care scenario, patients make appointments with their providers as problems arise and use ongoing support such as a 24-hour nurse line. Patients will have initial evaluations of gait and quality of life using instruments such as the SF-12 Health Survey, the Kokmen Short Test of Mental Status, and the PHQ-9 health questionnaire. Patients will be followed for 1 year for primary outcomes of hospitalizations and emergency department visits. Secondary analysis will include quality of life, compliance with the device, and attitudes about telemonitoring. Sample size is based on an 80% power to detect a 36% difference between the two groups. The primary analysis will involve Cox proportional time-to-event analysis. Secondary analysis will use t-test comparisons for continuous variables and the chi square test for proportional analysis. Discussion Patients randomized to home telemonitoring will have daily assessments of their health status using the device

  3. Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice

    OpenAIRE

    Besnard, Valérie; Matsuzaki, Yohei; Clark, Jean; Xu, Yan; Wert, Susan E.; Ikegami, Machiko; Stahlman, Mildred T.; Weaver, Timothy E.; Hunt, Alan N.; Postle, Anthony D.; Whitsett, Jeffrey A.

    2010-01-01

    ATP-binding cassette A3 (ABCA3) is a lipid transport protein required for synthesis and storage of pulmonary surfactant in type II cells in the alveoli. Abca3 was conditionally deleted in respiratory epithelial cells (Abca3Δ/Δ) in vivo. The majority of mice in which Abca3 was deleted in alveolar type II cells died shortly after birth from respiratory distress related to surfactant deficiency. Approximately 30% of the Abca3Δ/Δ mice survived after birth. Surviving Abca3Δ/Δ mice developed emphys...

  4. Active hold-down for heat treating

    Science.gov (United States)

    Collins, Jr., Earl R. (Inventor)

    1988-01-01

    A vacuum hold-down is described, for holding a thin film workpiece while it undergoes large temperature changes and corresponding dimensional changes, which permits creep of the workpiece to avoid damage thereto while still holding it on a support surface. The support surface has a multiplicity of holes arranged in a plurality of zones. The vacuum is repeatedly interrupted at the holes lying at different zones while it continues to be applied at the other zones, to permit creep of the workpiece at a zone when vacuum is not applied thereto.

  5. Home-based subcutaneous immunoglobulin G replacement therapy under real-life conditions in children and adults with antibody deficiency

    Directory of Open Access Journals (Sweden)

    Hoffmann F

    2010-06-01

    Full Text Available Abstract Background Subcutaneous immunoglobulin (SCIG therapy is an alternative to intravenous immunoglobulin (IVIG therapy. Methods We evaluated the efficacy and safety of the SCIG Vivaglobin® (formerly known as Beriglobin® SC under real-life conditions in a post-marketing observational study in 82 patients with primary or secondary antibody deficiencies. Health-related quality of life (HRQoL was evaluated in a subset of 30 patients previously treated with IVIG (including 11 children Results The mean serum immunoglobulin G (IgG trough level during SCIG treatment (7.5 g/L was higher than during previous IVIG treatment (6.6 g/L; p Conclusion This study confirms that therapy with Vivaglobin® at home is effective, safe, well tolerated, and improves quality of life in patients with antibody deficiency.

  6. Association of Psychosocial Conditions, Oral Health, and Dietary Variety with Intellectual Activity in Older Community-Dwelling Japanese Adults.

    Directory of Open Access Journals (Sweden)

    Kimiko Tomioka

    Full Text Available This study examined the factors related to intellectual activity in community-dwelling elderly persons.Self-administered questionnaires mailed to all people aged ≥65 years in a dormitory suburb in Japan (n = 15,210. The response rate was 72.2%. Analytical subjects (n = 8,910 were those who lived independently and completely answered questions about independent and dependent variables and covariates. Independent variables included psychosocial conditions (i.e., social activities, hobbies, and a sense that life is worth living (ikigai, oral health (i.e., dental health behaviors and oral function evaluated by chewing difficulties, swallowing difficulties, and oral dryness, and dietary variety measured using the dietary variety score (DVS. A dependent variable was intellectual activity measured using the Tokyo Metropolitan Institute of Gerontology Index of Competence. Covariates included age, gender, family structure, pensions, body mass index, alcohol, smoking, medical history, self-rated health, medications, cognitive function, depression, and falling. Logistic regression was used to estimate the odds ratio (OR for poor intellectual activity.Poor intellectual activity was reported by 28.9% of the study population. After adjustment for covariates and independent variables, poor intellectual activity was significantly associated with nonparticipation in social activities (OR = 1.90, 95%CI = 1.61-2.24, having neither hobbies nor ikigai (3.13, 2.55-3.84, having neither regular dental visits nor daily brushing (1.70, 1.35-2.14, the poorest oral function (1.61, 1.31-1.98, and the lowest DVS quartile (1.96, 1.70-2.26.These results indicate that psychosocial conditions, oral health, and dietary variety are independently associated with intellectual activity in elderly persons. The factors identified in this study may be used in community health programs for maintaining the intellectual activity ability of the elderly.

  7. Interactive effects of early and later nutritional conditions on the adult antioxidant defence system in zebra finches.

    Science.gov (United States)

    Noguera, José C; Monaghan, Pat; Metcalfe, Neil B

    2015-07-01

    In vertebrates, antioxidant defences comprise a mixture of endogenously produced components and exogenously obtained antioxidants that are derived mostly from the diet. It has been suggested that early-life micronutritional conditions might influence the way in which the antioxidant defence system operates, which could enable individuals to adjust the activity of the endogenous and exogenous components in line with their expected intake of dietary antioxidants if the future environment resembles the past. We investigated this possibility by experimentally manipulating the micronutrient content of the diet during different periods of postnatal development in the zebra finch (Taeniopygia guttata). Birds that had a low micronutrient diet during the growth phase initially had a lower total antioxidant capacity (TAC) than those reared under a high micronutrient diet, but then showed a compensatory response, so that by the end of the growth phase, the TAC of the two groups was the same. Interestingly, we found an interactive effect of micronutrient intake early and late in development: only those birds that continued with the same dietary treatment (low or high) throughout development showed a significant increase in their TAC during the period of sexual maturation. A similar effect was also found in the level of enzymatic antioxidant defences (glutathione peroxidase; GPx). No significant effects were found in the level of oxidative damage in lipids [malondialdehyde (MDA) levels]. These findings demonstrate the importance of early and late developmental conditions in shaping multiple aspects of the antioxidant system. Furthermore, they suggest that young birds may adjust their antioxidant defences to enable them to 'thrive' on diets rich or poor in micronutrients later in life. PMID:25987737

  8. Surface expression of hippocampal NMDA GluN2B receptors regulated by fear conditioning determines its contribution to memory consolidation in adult rats.

    Science.gov (United States)

    Sun, Yan-Yan; Cai, Wei; Yu, Jie; Liu, Shu-Su; Zhuo, Min; Li, Bao-Ming; Zhang, Xue-Han

    2016-01-01

    The number and subtype composition of N-methyl-d-aspartate receptor (NMDAR) at synapses determines their functional properties and role in learning and memory. Genetically increased or decreased amount of GluN2B affects hippocampus-dependent memory in the adult brain. But in some experimental conditions (e.g., memory elicited by a single conditioning trial (1 CS-US)), GluN2B is not a necessary factor, which indicates that the precise role of GluN2B in memory formation requires further exploration. Here, we examined the role of GluN2B in the consolidation of fear memory using two training paradigms. We found that GluN2B was only required for the consolidation of memory elicited by five conditioning trials (5 CS-US), not by 1 CS-US. Strikingly, the expression of membrane GluN2B in CA1was training-strength-dependently increased after conditioning, and that the amount of membrane GluN2B determined its involvement in memory consolidation. Additionally, we demonstrated the increases in the activities of cAMP, ERK, and CREB in the CA1 after conditioning, as well as the enhanced intrinsic excitability and synaptic efficacy in CA1 neurons. Up-regulation of membrane GluN2B contributed to these enhancements. These studies uncover a novel mechanism for the involvement of GluN2B in memory consolidation by its accumulation at the cell surface in response to behavioral training. PMID:27487820

  9. Surface expression of hippocampal NMDA GluN2B receptors regulated by fear conditioning determines its contribution to memory consolidation in adult rats

    Science.gov (United States)

    Sun, Yan-Yan; Cai, Wei; Yu, Jie; Liu, Shu-Su; Zhuo, Min; Li, Bao-Ming; Zhang, Xue-Han

    2016-01-01

    The number and subtype composition of N-methyl-d-aspartate receptor (NMDAR) at synapses determines their functional properties and role in learning and memory. Genetically increased or decreased amount of GluN2B affects hippocampus-dependent memory in the adult brain. But in some experimental conditions (e.g., memory elicited by a single conditioning trial (1 CS-US)), GluN2B is not a necessary factor, which indicates that the precise role of GluN2B in memory formation requires further exploration. Here, we examined the role of GluN2B in the consolidation of fear memory using two training paradigms. We found that GluN2B was only required for the consolidation of memory elicited by five conditioning trials (5 CS-US), not by 1 CS-US. Strikingly, the expression of membrane GluN2B in CA1was training-strength-dependently increased after conditioning, and that the amount of membrane GluN2B determined its involvement in memory consolidation. Additionally, we demonstrated the increases in the activities of cAMP, ERK, and CREB in the CA1 after conditioning, as well as the enhanced intrinsic excitability and synaptic efficacy in CA1 neurons. Up-regulation of membrane GluN2B contributed to these enhancements. These studies uncover a novel mechanism for the involvement of GluN2B in memory consolidation by its accumulation at the cell surface in response to behavioral training. PMID:27487820

  10. Alternative Medicine Taking Hold Among Americans: Report

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_159511.html Alternative Medicine Taking Hold Among Americans: Report More than $30 ... chunk of their health care dollars on alternative medicine, such as acupuncture, yoga, chiropractic care and natural ...

  11. Validity of actigraphs uniaxial and triaxial accelerometers for assessment of physical activity in adults in laboratory conditions

    International Nuclear Information System (INIS)

    Few studies to date have directly compared the Actigraphs GT1M and the GT3X, it would be of tremendous value to know if these accelerometers give similar information about intensities of PA. Knowing if output is similar would have implications for cross-examination of studies. The purpose of the study was to assess the validity of the GT1M and the GT3X Actigraph accelerometers for the assessment of physical activity against oxygen consumption in laboratory conditions. Forty-two college-aged participants aged 18-25 years wore the GT1M and the GT3X on their right hip during treadmill exercise at three different speeds, slow walking 4.8 km.h-1, fast walking 6.4 km.h-1, and running 9.7 km.h-1). Oxygen consumption was measured minute-by minute using a metabolic system. Bland-Altman plots were used to assess agreement between activity counts from the GT3X and GT1M, and correlations were assessed the ability of the accelerometers to assess physical activity. Bias for 4.8 km.h-1 was 2814.4 cpm (limits 1211.3 to 4417.4), for 6.4 km.h-1 was 3713.6 cpm (limits 1573.2 to 5854.0), and for 9.7 km.h-1 was−3811.2 cpm (limits 842.1 to 6780.3). Correlations between counts per minute for the GT1M and the GT3X were significantly correlated with VO2 (r = 0.881, p < 0.001; r = 0.810, p < 0.001 respectively). The present study showed that both the GT1M and the GT3X accurately measure physical activity when compared to oxygen consumption

  12. High voltage holding in the negative ion sources with cesium deposition

    Energy Technology Data Exchange (ETDEWEB)

    Belchenko, Yu.; Abdrashitov, G.; Ivanov, A.; Sanin, A.; Sotnikov, O., E-mail: O.Z.Sotnikov@inp.nsk.su [Budker Institute of Nuclear Physics, Siberian Branch of Russian Academy of Sciences, Novosibirsk (Russian Federation)

    2016-02-15

    High voltage holding of the large surface-plasma negative ion source with cesium deposition was studied. It was found that heating of ion-optical system electrodes to temperature >100 °C facilitates the source conditioning by high voltage pulses in vacuum and by beam shots. The procedure of electrode conditioning and the data on high-voltage holding in the negative ion source with small cesium seed are described. The mechanism of high voltage holding improvement by depletion of cesium coverage is discussed.

  13. 12 CFR 575.14 - Subsidiary holding companies.

    Science.gov (United States)

    2010-01-01

    ... subsidiary holding company conducts in accordance with the purchase priorities set forth in 12 CFR part 563b... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Subsidiary holding companies. 575.14 Section... COMPANIES § 575.14 Subsidiary holding companies. (a) Subsidiary holding companies. A mutual holding...

  14. Long-Term Fate Mapping Using Conditional Lentiviral Vectors Reveals a Continuous Contribution of Radial Glia-Like Cells to Adult Hippocampal Neurogenesis in Mice.

    Directory of Open Access Journals (Sweden)

    Sarah-Ann Aelvoet

    Full Text Available Newborn neurons are generated throughout life in two neurogenic regions, the subventricular zone and the hippocampal dentate gyrus. Stimulation of adult neurogenesis is considered as an attractive endogenous repair mechanism to treat different neurological disorders. Although tremendous progress has been made in our understanding of adult hippocampal neurogenesis, important questions remain unanswered, regarding the identity and the behavior of neural stem cells in the dentate gyrus. We previously showed that conditional Cre-Flex lentiviral vectors can be used to label neural stem cells in the subventricular zone and to track the migration of their progeny with non-invasive bioluminescence imaging. Here, we applied these Cre-Flex lentiviral vectors to study neurogenesis in the dentate gyrus with bioluminescence imaging and histological techniques. Stereotactic injection of the Cre-Flex vectors into the dentate gyrus of transgenic Nestin-Cre mice resulted in specific labeling of the nestin-positive neural stem cells. The labeled cell population could be detected with bioluminescence imaging until 9 months post injection, but no significant increase in the number of labeled cells over time was observed with this imaging technique. Nevertheless, the specific labeling of the nestin-positive neural stem cells, combined with histological analysis at different time points, allowed detailed analysis of their neurogenic potential. This long-term fate mapping revealed that a stable pool of labeled nestin-positive neural stem cells continuously contributes to the generation of newborn neurons in the mouse brain until 9 months post injection. In conclusion, the Cre-Flex technology is a valuable tool to address remaining questions regarding neural stem cell identity and behavior in the dentate gyrus.

  15. 78 FR 64596 - Celerity Partners IV, LLC, Celerity AHI Holdings SPV, LLC, and All Aboard America! Holdings, Inc...

    Science.gov (United States)

    2013-10-29

    ... Surface Transportation Board Celerity Partners IV, LLC, Celerity AHI Holdings SPV, LLC, and All Aboard... America! Holdings, Inc. (AHI), Celerity AHI Holdings SPV, LLC (Celerity Holdings), and Celerity Partners..., New Mexico, and Texas. \\2\\ See Celerity Partners IV, LLC, Celerity AHI Holdings SPV, LLC, and...

  16. Association between ambient air pollution, meteorological conditions and exacerbations of asthma and chronic obstructive pulmonary disease in adult citizens of the town of Smederevo

    Directory of Open Access Journals (Sweden)

    Stevanović Ivan

    2016-01-01

    Full Text Available Introduction. Smederevo is the only town in Serbia with a steel factory, whose exhausts contribute to air pollution. Therefore, the city conducts continuous monitoring of air quality. In recent years, high levels of particulate matter (PM, including coarse (PM10 and fine (PM2.5 particles in the air have frequently been recorded. The aim of this study was to assess association between exacerbation of asthma or chronic obstructive pulmonary disease (COPD in adults and air pollution or meteorological conditions. Methods. The study was conducted in the secondary care General Hospital in Smederevo covering approximately 81, 000 inhabitants living in the area of about 7 km around the automatic station for air quality monitoring from which the verified data were collected. Data on patients were obtained from medical records. The correlation between the incidence of diseases exacerbation and the number of days with exceedance of air pollutants limit level per month, as well as meteorological conditions, was tested with parametric Pearson bivariate correlation test in program SPSS. Results. The study population consisted of adults registered as asthma or COPD suffering patients (n = 1,624 with 570 episodes of remarkable exacerbations (moderate or severe of the disease in 2011. Asthma exacerbation was significantly more frequent in women than in men. The number of days with high levels of PM2.5 per month was statistically significantly associated with the total number of exacerbation (moderate and severe of both asthma and COPD episodes among the female patients. There was also a statistically significant association between the number of days with PM2.5 exceedance and the number of moderate exacerbations in the subgroups of nonsmokers and obese patients. A significant correlation of the number of days with the exceedance of PM10 limit level was shown only for the subgroup of obese, non-smoking patients with moderate exacerbation. A significant negative

  17. Decompression sickness following breath-hold diving.

    Science.gov (United States)

    Schipke, J D; Gams, E; Kallweit, Oliver

    2006-01-01

    Despite convincing evidence of a relationship between breath-hold diving and decompression sickness (DCS), the causal connection is only slowly being accepted. Only the more recent textbooks have acknowledged the risks of repetitive breath-hold diving. We compare four groups of breath-hold divers: (1) Japanese and Korean amas and other divers from the Pacific area, (2) instructors at naval training facilities, (3) spear fishers, and (4) free-dive athletes. While the number of amas is likely decreasing, and Scandinavian Navy training facilities recorded only a few accidents, the number of spear fishers suffering accidents is on the rise, in particular during championships or using scooters. Finally, national and international associations (e.g., International Association of Free Drives [IAFD] or Association Internationale pour Le Developpment De L'Apnee [AIDA]) promote free-diving championships including deep diving categories such as constant weight, variable weight, and no limit. A number of free-diving athletes, training for or participating in competitions, are increasingly accident prone as the world record is presently set at a depth of 171 m. This review presents data found after searching Medline and ISI Web of Science and using appropriate Internet search engines (e.g., Google). We report some 90 cases in which DCS occurred after repetitive breath-hold dives. Even today, the risk of suffering from DCS after repetitive breath-hold diving is often not acknowledged. We strongly suggest that breath-hold divers and their advisors and physicians be made aware of the possibility of DCS and of the appropriate therapeutic measures to be taken when DCS is suspected. Because the risk of suffering from DCS increases depending on depth, bottom time, rate of ascent, and duration of surface intervals, some approaches to assess the risks are presented. Regrettably, none of these approaches is widely accepted. We propose therefore the development of easily manageable

  18. Control of Precision Grip Force in Lifting and Holding of Low-Mass Objects.

    Directory of Open Access Journals (Sweden)

    Yuichi Hiramatsu

    Full Text Available Few studies have investigated the control of grip force when manipulating an object with an extremely small mass using a precision grip, although some related information has been provided by studies conducted in an unusual microgravity environment. Grip-load force coordination was examined while healthy adults (N = 17 held a moveable instrumented apparatus with its mass changed between 6 g and 200 g in 14 steps, with its grip surface set as either sandpaper or rayon. Additional measurements of grip-force-dependent finger-surface contact area and finger skin indentation, as well as a test of weight discrimination, were also performed. For each surface condition, the static grip force was modulated in parallel with load force while holding the object of a mass above 30 g. For objects with mass smaller than 30 g, on the other hand, the parallel relationship was changed, resulting in a progressive increase in grip-to-load force (GF/LF ratio. The rayon had a higher GF/LF force ratio across all mass levels. The proportion of safety margin in the static grip force and normalized moment-to-moment variability of the static grip force were also elevated towards the lower end of the object mass for both surfaces. These findings indicate that the strategy of grip force control for holding objects with an extremely small mass differs from that with a mass above 30 g. The data for the contact area, skin indentation, and weight discrimination suggest that a decreased level of cutaneous feedback signals from the finger pads could have played some role in a cost function in efficient grip force control with low-mass objects. The elevated grip force variability associated with signal-dependent and internal noises, and anticipated inertial force on the held object due to acceleration of the arm and hand, could also have contributed to the cost function.

  19. Cognitive-motor interference while grasping, lifting and holding objects.

    Directory of Open Access Journals (Sweden)

    Erwan Guillery

    Full Text Available In daily life, object manipulation is usually performed concurrently to the execution of cognitive tasks. The aim of the present study was to determine which aspects of precision grip require cognitive resources using a motor-cognitive dual-task paradigm. Eighteen healthy participants took part in the experiment, which comprised two conditions. In the first condition, participants performed a motor task without any concomitant cognitive task. They were instructed to grip, lift and hold an apparatus incorporating strain gauges allowing a continuous measurement of the force perpendicular to each contact surface (grip force, GF as well as the total tangential force applied on the object (load force, LF. In the second condition, participants performed the same motor task while concurrently performing a cognitive task consisting in a complex visual search combined with counting. In the dual-task condition, we found a significant increase in the duration of the preload phase (time between initial contact of the fingers with the apparatus and onset of the load force, as well as a significant increase of the grip force during the holding phase, indicating that the cognitive task interfered with the initial force scaling performed during the preload phase and the fine-tuning of grip force during the hold phase. These findings indicate that these aspects of precision grip require cognitive resources. In contrast, other aspects of the precision grip, such as the temporal coupling between grip and load forces, were not affected by the cognitive task, suggesting that they reflect more automatic processes. Taken together, our results suggest that assessing the dynamic and temporal parameters of precision grip in the context of a concurrent cognitive task may constitute a more ecological and better-suited tool to characterize motor dysfunction in patients.

  20. Appealing Features of Vocational Support Services for Hispanic and non-Hispanic Transition Age Youth and Young Adults with Serious Mental Health Conditions.

    Science.gov (United States)

    Stone, Rosalie A Torres; Delman, Jonathan; McKay, Colleen E; Smith, Lisa M

    2015-10-01

    Transition age youth and young adults (TAYYAs) diagnosed with serious mental health conditions (SMHCs) are at greater risk of being unemployed compared to their peers without SMHCs. Job counseling and job placement services are the greatest predictor of competitive employment, yet we have limited knowledge about what TAYYAs believe they need to obtain gainful employment. In person, qualitative interviews were conducted with 57 non-Hispanic and Hispanic TAYYAs with SMHCs enrolled in three vocational support programs in MA (Vocational Rehabilitation, Individual Placement and Support; the Clubhouse Model as described by the International Center for Clubhouse Development). Six themes emerged from the data: three themes were identified as social capital (supportive relationships, readily available workplace supports, and vocational preparation), two themes related to human capital (effective educational supports and work experience), and one theme related to cultural capital (social skills training). Unique features (Spanish-speaking staff and/or familiar in Latino culture, familial-like staff support) were frequently noted by Hispanic TAYYAs. PMID:24647622

  1. How Much Popcorn Will Our Classroom Hold?

    Science.gov (United States)

    Rommel-Esham, Katie

    2007-01-01

    "How much popcorn will our classroom hold?" This intriguing question sparked a terrific integrated science and math exploration that the author conducted with fifth-and sixth-grade students. In the process of finding the classroom's volume, students developed science-process skills (e.g., developing a plan, measurement, collecting and interpreting…

  2. Should we Hold the Obese Responsible?

    DEFF Research Database (Denmark)

    Nielsen, Morten Ebbe Juul; Andersen, Martin Marchman

    2014-01-01

    of responsibility puts aside questions of the past and holds a person responsible by reference to some desirable future state of affairs and will typically mean that he or she is subjected to criticism, censure, or other negative appraisals or that he or she is held cost-responsible in some form, for example...

  3. Electric disc brakes hold nuclear aircraft carriers

    International Nuclear Information System (INIS)

    Two nuclear-powered aircraft carriers, the U.S.S. Nimitz and the soon-to-be-completed U.S.S. Dwight D. Eisenhower, use electric disc brakes to stop and hold lines on warping and mooring capstans during docking maneuvers and mooring operations

  4. Package Holds Five Monolithic Microwave Integrated Circuits

    Science.gov (United States)

    Mysoor, Narayan R.; Decker, D. Richard; Olson, Hilding M.

    1996-01-01

    Packages protect and hold monolithic microwave integrated circuit (MMIC) chips while providing dc and radio-frequency (RF) electrical connections for chips undergoing development. Required to be compact, lightweight, and rugged. Designed to minimize undesired resonances, reflections, losses, and impedance mismatches.

  5. CNPC Hong Kong (Holdings) Ltd. Established

    Institute of Scientific and Technical Information of China (English)

    Wu Yaowen; Yang Hanfeng

    1997-01-01

    @@ On the occasion of the return of Hong Kong to the motherland, CNPC Hong Kong (Holdings) Ltd. is formally established in April, 1997 in Hong Kong. This important event marks the beginning of a new and prosperous stage in the trade and economic cooperation currently forged between the mainland petroleum industry and Hong Kong's financial,industrial and commercial circles.

  6. Empowerment Amongst Teachers Holding Leadership Positions

    Science.gov (United States)

    Avidov-Ungar, Orit; Friedman, Izhak; Olshtain, Elite

    2014-01-01

    This study used semi-structured in-depth interviews to explore empowerment patterns among teachers who hold leadership positions in school. Our qualitative analysis presents a hierarchical ladder with three types of empowerment amongst these teachers, ranging from limited empowerment through rewarding empowerment to change-enhancing empowerment.…

  7. Whether to sell or hold a stock

    OpenAIRE

    Rishel, Raymond

    2006-01-01

    For a simple model of a stock, whose stock price is a geometric Brownian motion in which the drift rate changes back and forth between positive and negative values, optimal selling times are computed. An infinite optimal selling time meaning you should just hold the stock.

  8. The Mental Health of Older LGBT Adults.

    Science.gov (United States)

    Yarns, Brandon C; Abrams, Janet M; Meeks, Thomas W; Sewell, Daniel D

    2016-06-01

    There are approximately one million older lesbian, gay, bisexual, and transgender (LGBT) adults in the USA. Their mental health issues result from interactions between genetic factors and stress associated with membership in a sexual minority group. Although advancements in acceptance and equal treatment of LGBT individuals have been occurring, sexual minority status remains associated with risks to physical and mental well-being. Older LGBT adults are more likely to have experienced mistreatment and discrimination due to living a majority of their lives prior to recent advancements in acceptance and equal treatment. All LGBT adults experience one common developmental challenge: deciding if, when, and how to reveal to others their gender identity and/or sexual orientation. LGBT individuals have higher rates of anxiety, depression, and substance use disorders and also are at increased risk for certain medical conditions like obesity, breast cancer, and human immunodeficiency virus (HIV). Improved education and training of clinicians, coupled with clinical research efforts, holds the promise of improved overall health and life quality for older LGBT adults. PMID:27142205

  9. Hold-Up Time Analysis of a DC-Link Module With a Series Voltage Compensator

    DEFF Research Database (Denmark)

    Wang, Huai; Liu, Wenchao; Chung, Henry

    2012-01-01

    A dc-link module composed of dc-link capacitors and a series voltage compensator has been proposed. It has been verified that the module can reduce the dc-link capacitance to 10–20% while achieving a very low voltage ripple across its output terminals. This paper investigates the required dc......-link capacitance when a certain period of hold-up time is considered. Trade-off design conditions are presented and the hold-up time is compared with the solution without the series voltage compensator. The analysis is crucial to power converters connected to critical loads when hold-up time is required. The...

  10. Pharmacokinetics of single oral dose trazodone : a randomized, two-period, cross-over trial in healthy, adult, human volunteers under fed condition

    Directory of Open Access Journals (Sweden)

    PRASHANT eKALE

    2015-10-01

    Full Text Available Objective To assess the bioequivalence of single dose trazodone hydrochloride USP 100 mg tablets administered as an oral dose under fed condition. Methods This study was an open-label, balanced, randomized, two-sequence, two-treatment, two-period, single oral dose, crossover bioequivalence study in healthy, adult, human subjects under fed conditions. After an overnight fast of at least 10 hours, the subjects were served a high fat and high calorie vegetarian breakfast, which they were required to consume within 30 minutes. A single oral dose (100 mg of either the test or the reference product was administered to the subjects. The primary pharmacokinetic parameters, maximum plasma concentration (Cmax and area under the plasma concentration–time curve (AUC from time zero to last measurable concentration (AUC0-t and extrapolated to infinity (AUC0- were compared by an analysis of variance using log-transformed data. Bioequivalence was concluded if the 90% confidence intervals (CIs of the adjusted geometric mean (gMean ratios for Cmax and AUC were within the predetermined range of 80%-125%, in accordance with regulatory requirements. Results For the test formulation, the trazodone gMean Cmax was 1480.9 ng/mL (vs. 1520.2 ng/mL for reference, AUC0-t was 18193.0 ng·h/mL (vs. 18209.8 ng·h/mL and AUC0- was 19346.3 ng·h/mL (vs. 19393.4 ng·h/mL. The 90% CIs for the ratio (test/reference were 93.0-102.0% for Cmax, 96.7-103.2% for AUC0-t and 96.1-103.5% for AUC0-. There were no deaths or serious adverse events during the conduct of the study. Conclusion Test product when compared with the Reference product meets the bioequivalence criteria with respect to the rate and extent of absorption of Trazodone under fed condition.

  11. 26 CFR 301.9100-9T - Election by a bank holding company to forego grandfather provision for all property representing...

    Science.gov (United States)

    2010-04-01

    ... described in the proviso of section 4(a)(2) of the Bank Holding Company Act). (f) Conditional certification... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Election by a bank holding company to forego... Election by a bank holding company to forego grandfather provision for all property representing...

  12. The effects of breath-holding on pulmonary regurgitation measured by cardiovascular magnetic resonance velocity mapping

    Directory of Open Access Journals (Sweden)

    Babu-Narayan Sonya V

    2009-01-01

    Full Text Available Abstract Background Pulmonary regurgitation is a common and clinically important residual lesion after repair of tetralogy of Fallot. Cardiovascular magnetic resonance (CMR phase contrast velocity mapping is widely used for measurement of pulmonary regurgitant fraction. Breath-hold acquisitions, usually acquired during held expiration, are more convenient than the non-breath-hold approach, but we hypothesized that breath-holding might affect the amount of pulmonary regurgitation. Methods Forty-three adult patients with a previous repair of tetralogy of Fallot and residual pulmonary regurgitation were investigated with CMR. In each, pulmonary regurgitant fraction was measured from velocity maps transecting the pulmonary trunk, acquired during held expiration, held inspiration, by non-breath-hold acquisition, and also from the difference of right and left ventricular stroke volume measurements. Results Pulmonary regurgitant fraction was lower when measured by velocity mapping in held expiration compared with held inspiration, non-breath-hold or stroke volume difference (30.8 vs. 37.0, 35.6, 35.4%, p = 0.00017, 0.0035, 0.026. The regurgitant volume was lower in held expiration than in held inspiration (41.9 vs. 48.3, p = 0.0018. Pulmonary forward flow volume was larger during held expiration than during non-breath-hold (132 vs. 124 ml, p = 0.0024. Conclusion Pulmonary regurgitant fraction was significantly lower in held expiration compared with held inspiration, free breathing and stroke volume difference. Altered airway pressure could be a contributory factor. This information is relevant if breath-hold acquisition is to be substituted for non-breath-hold in the investigation of patients with a view to re-intervention.

  13. 12 CFR 225.124 - Foreign bank holding companies.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Foreign bank holding companies. 225.124 Section... SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.124 Foreign bank holding companies. (a) Effective December 1, 1971,...

  14. 26 CFR 53.4943-8 - Business holdings; constructive ownership.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Business holdings; constructive ownership. 53... Business Holdings § 53.4943-8 Business holdings; constructive ownership. (a) Constructive ownership—(1) In general. For purposes of section 4943, in computing the holdings in a business enterprise of a...

  15. 12 CFR 583.20 - Savings and loan holding company.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Savings and loan holding company. 583.20... REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.20 Savings and loan holding company. The term savings and loan holding company means any company that directly or indirectly controls a...

  16. 12 CFR 583.4 - Bank holding company.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Bank holding company. 583.4 Section 583.4 Banks... AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.4 Bank holding company. The term bank holding company means any company which has control over any bank or over any company that is or becomes a bank...

  17. Adult Human Neurogenesis: from Microscopy to Magnetic Resonance Imaging

    Directory of Open Access Journals (Sweden)

    AmandaSierra

    2011-04-01

    Full Text Available Neural stem cells reside in well-defined areas of the adult human brain and are capable of gene-rating new neurons throughout the life span. In rodents, it is well established that the new born neurons are involved in olfaction as well as in certain forms of memory and learning. In humans, the functional relevance of adult human neurogenesis is being investigated, in particular its implication in the etiopathology of a variety of brain disorders. Adult neurogenesis in the human brain was discovered by utilizing methodologies directly imported from the rodent research, such as immunohistological detection of proliferation and cell-type specific biomarkers in postmortem or biopsy tissue. However, in the vast majority of cases, these methods do not support longitudinal studies; thus, the capacity of the putative stem cells to form new neurons under different disease conditions cannot be tested. More recently, new technologies have been specifically developed for the detection and quantification of neural stem cells in the living human brain. These technologies rely on the use of magnetic resonance imaging, available in hospitals worldwide. Although they require further validation in rodents and primates, these new methods hold the potential to test the contribution of adult human neurogenesis to brain function in both health and disease. This review reports on the current knowledge on adult human neurogenesis. We first review the different methods available to assess human neurogenesis, both ex vivo and in vivo and then appraise the changes of adult neurogenesis in human diseases.

  18. 78 FR 31590 - Sears Holdings Management Corporation, A Division Of Sears Holdings Corporation, Hoffman Estates...

    Science.gov (United States)

    2013-05-24

    ... management segment of the supply chain unit. The Department also received information from the subject firm... management services, another petitioner supplied project coordinator analytics services, and the third... Employment and Training Administration Sears Holdings Management Corporation, A Division Of Sears...

  19. The Effect of Education on Equity Holdings

    OpenAIRE

    Hryshko, Dmytro; Luengo-Prado, Maria; Bent E. Sørensen

    2010-01-01

    We study the effect of education on equity ownership in the form of stocks or mutual funds (outside of retirement accounts). We find a causal effect of education on stockholding using the number of colleges in the county where the respondent grew up as an instrument and data from the Panel Study of Income Dynamics. The effect is particularly strong for whites from non-privileged backgrounds. We explore the channels through which education affects equity holdings using the Wisconsin Longitudin...

  20. Novel Findings in Breath-Holding Spells

    OpenAIRE

    Azab, Seham F. A.; Siam, Ahmed G.; Saleh, Safaa H.; Elshafei, Mona M.; Elsaeed, Wafaa F.; Arafa, Mohamed A.; Bendary, Eman A.; Farag, Elsayed M.; Basset, Maha A.A.; Ismail, Sanaa M.; Elazouni, Osama M.A.

    2015-01-01

    Abstract The mechanism of breath-holding spells (BHS) is not fully understood and most probably multifactorial; so, this study was designed to clarify the pathophysiology of BHS through assessing some laboratory parameters and electrocardiographic (ECG) changes which might be contributing to the occurrence of the attacks. Another aim of the study was to evaluate the differences in the pathophysiology between pallid and cyanotic types of BHS. This was a prospective study performed in Zagazig U...

  1. Saskatchewan Energy Holdings Ltd. consolidated financial statements

    International Nuclear Information System (INIS)

    The consolidated financial statements of Saskatchewan Energy Holdings Ltd. (formerly Saskatchewan Energy Corporation) as of December 31, 1990, and the consolidated statements of earnings and retained earnings and changes in cash position for the year are presented. Data include an inventory of supplies, natural gas in storage, property, plant and equipment. Financial statements are also presented for the year ending December 31, 1989, with comparative figures for the seven months ending December 31, 1988

  2. Prevalence of influenza vaccination and its association with health conditions and risk factors among Kansas adults in 2013: a cross-sectional study

    OpenAIRE

    Santaularia, Jeanie; Hou, Wei; Perveen, Ghazala; Welsh, Ericka; Faseru, Babalola

    2016-01-01

    Background According to the Centers for Disease Control and Prevention, approximately 5-20 % of people are affected by influenza annually, and influenza causes more than 200,000 hospitalizations each year. The purpose of this study is to estimate the prevalence of influenza vaccination among high risk adults in Kansas. Methods The 2013 Kansas BRFSS data (n = 20,712) were analyzed to assess the prevalence of receiving influenza vaccination among Kansas adults, overall and for selected demograp...

  3. Consecutive Intake of Fermented Milk Containing Bifidobacterium breve Strain Yakult and Galacto-oligosaccharides Benefits Skin Condition in Healthy Adult Women

    OpenAIRE

    Kano, Mitsuyoshi; MASUOKA, Norie; Kaga, Chiaki; SUGIMOTO, Saho; IIZUKA, Ryoko; MANABE, Katsuyuki; SONE, Toshiro; OEDA, Kazutoshi; NONAKA, Chiaki; MIYAZAKI, Kouji; ISHIKAWA, Fumiyasu

    2013-01-01

    A double-blind, placebo-controlled, randomized trial was conducted to investigate the beneficial effect of probiotic and prebiotic fermented milk on the skin of healthy adult women. Forty healthy Japanese adult female volunteers with healthy skin randomly received either a bottle of probiotic and prebiotic fermented milk containing Bifidobacterium breve strain Yakult and galacto-oligosaccharides (GOS) (active group) or a non-fermented placebo milk containing neither probiotics nor GOS (placeb...

  4. Effects of a tongue-holding maneuver during swallowing evaluated by high-resolution manometry.

    OpenAIRE

    Umeki, Hiroshi; Takasaki, Kenji; Enatsu, Kaori; Tanaka, Fujinobu; Kumagami, Hidetaka; Takahashi, Haruo

    2009-01-01

    OBJECTIVE: This study aimed to investigate the effects of a tongue-holding maneuver (THM) during swallowing using a novel high-resolution manometry (HRM) system. STUDY DESIGN: Case series with planned data collection. MATERIALS AND METHODS: Thirty-three asymptomatic Japanese adults were studied. A solid-state HRM assembly with 36 circumferential sensors spaced 1-cm apart was positioned to record pressures from the velopharynx to the upper esophagus at rest and during swallowing. The maximum v...

  5. Energy cost and optimisation in breath-hold diving.

    Science.gov (United States)

    Trassinelli, M

    2016-05-01

    We present a new model for calculating locomotion costs in breath-hold divers. Starting from basic mechanics principles, we calculate the work that the diver must provide through propulsion to counterbalance the action of drag, the buoyant force and weight during immersion. Compared to those in previous studies, the model presented here accurately analyses breath-hold divers which alternate active swimming with prolonged glides during the dive (as is the case in mammals). The energy cost of the dive is strongly dependent on these prolonged gliding phases. Here we investigate the length and impacts on energy cost of these glides with respect to the diver characteristics, and compare them with those observed in different breath-hold diving species. Taking into account the basal metabolic rate and chemical energy to propulsion transformation efficiency, we calculate optimal swim velocity and the corresponding total energy cost (including metabolic rate) and compare them with observations. Energy cost is minimised when the diver passes through neutral buoyancy conditions during the dive. This generally implies the presence of prolonged gliding phases in both ascent and descent, where the buoyancy (varying with depth) is best used against the drag, reducing energy cost. This is in agreement with past results (Miller et al., 2012; Sato et al., 2013) where, when the buoyant force is considered constant during the dive, the energy cost was minimised for neutral buoyancy. In particular, our model confirms the good physical adaption of dolphins for diving, compared to other breath-hold diving species which are mostly positively buoyant (penguins for example). The presence of prolonged glides implies a non-trivial dependency of optimal speed on maximal depth of the dive. This extends previous findings (Sato et al., 2010; Watanabe et al., 2011) which found no dependency of optimal speed on dive depth for particular conditions. The energy cost of the dive can be further

  6. Synchronized Position Hold, Engage, Reorient, Experimental Satellites

    Science.gov (United States)

    Miller, David W.; Wilson, Edward; How, Jonathan; Sanenz-Otero, Alvar; Chamitoff, Gregory

    2009-01-01

    Synchronized Position Hold, Engage, Reorient, Experimental Satellites (SPHERES) are bowling-ball sized spherical satellites. They will be used inside the space station to test a set of well-defined instructions for spacecraft performing autonomous rendezvous and docking maneuvers. Three free-flying spheres will fly within the cabin of the station, performing flight formations. Each satellite is self-contained with power, propulsion, computers and navigation equipment. The results are important for satellite servicing, vehicle assembly and formation flying spacecraft configurations. SPHERES is a testbed for formation flying by satellites, the theories and calculations that coordinate the motion of multiple bodies maneuvering in microgravity. To achieve this inside the ISS cabin, bowling-ball-sized spheres perform various maneuvers (or protocols), with one to three spheres operating simultaneously . The Synchronized Position Hold, Engage, Reorient, Experimental Satellites (SPHERES) experiment will test relative attitude control and station-keeping between satellites, re-targeting and image plane filling maneuvers, collision avoidance and fuel balancing algorithms, and an array of geometry estimators used in various missions. SPHERES consists of three self-contained satellites, which are 18 sided polyhedrons that are 0.2 meter in diameter and weigh 3.5 kilograms. Each satellite contains an internal propulsion system, power, avionics, software, communications, and metrology subsystems. The propulsion system uses CO2, which is expelled through the thrusters. SPHERES satellites are powered by AA batteries. The metrology subsystem provides real-time position and attitude information. To simulate ground station-keeping, a laptop will be used to transmit navigational data and formation flying algorithms. Once these data are uploaded, the satellites will perform autonomously and hold the formation until a new command is given.

  7. A conceptual holding model for veterinary applications

    Directory of Open Access Journals (Sweden)

    Nicola Ferrè

    2014-05-01

    Full Text Available Spatial references are required when geographical information systems (GIS are used for the collection, storage and management of data. In the veterinary domain, the spatial component of a holding (of animals is usually defined by coordinates, and no other relevant information needs to be interpreted or used for manipulation of the data in the GIS environment provided. Users trying to integrate or reuse spatial data organised in such a way, frequently face the problem of data incompatibility and inconsistency. The root of the problem lies in differences with respect to syntax as well as variations in the semantic, spatial and temporal representations of the geographic features. To overcome these problems and to facilitate the inter-operability of different GIS, spatial data must be defined according to a “schema” that includes the definition, acquisition, analysis, access, presentation and transfer of such data between different users and systems. We propose an application “schema” of holdings for GIS applications in the veterinary domain according to the European directive framework (directive 2007/2/EC - INSPIRE. The conceptual model put forward has been developed at two specific levels to produce the essential and the abstract model, respectively. The former establishes the conceptual linkage of the system design to the real world, while the latter describes how the system or software works. The result is an application “schema” that formalises and unifies the information-theoretic foundations of how to spatially represent a holding in order to ensure straightforward information-sharing within the veterinary community.

  8. A mathematical model of aerosol holding chambers

    DEFF Research Database (Denmark)

    Zak, M; Madsen, J; Berg, E;

    1999-01-01

    A mathematical model of aerosol delivery from holding chambers (spacers) was developed incorporating tidal volume (VT), chamber volume (Vch), apparatus dead space (VD), effect of valve insufficiency and other leaks, loss of aerosol by immediate impact on the chamber wall, and fallout of aerosol......-mentioned factors, initial loss of aerosol by impact on the chamber wall is most important for the efficiency of a spacer. With a VT of 195 mL, the AeroChamber and Babyhaler were emptied in two breaths, the NebuChamber in four breaths, and the Nebuhaler in six breaths. Insufficiencies of the expiratory valves were...

  9. ON THE DEVELOPMENTAL THEORY OF AGING .1. STARVATION RESISTANCE AND LONGEVITY IN DROSOPHILA-MELANOGASTER IN RELATION TO PRE-ADULT BREEDING CONDITIONS

    NARCIS (Netherlands)

    ZWAAN, BJ; BIJLSMA, R; HOEKSTRA, RF

    1991-01-01

    The developmental theory of ageing predicts a positive correlation between developmental time and adult longevity. Experiments that vary larval density and food level have been carried out to test this prediction. The results show differences in viability, developmental time, starvation resistance a

  10. The Design of Reactor Internals Hold-Down Spring

    Directory of Open Access Journals (Sweden)

    Guohong Xue

    2016-01-01

    Full Text Available Hold down spring(HDS, clamped between the upper support plate flange and the core barrel flange inside a pressurized reactor vessel, is used to provide a downward force to keep the core barrel stable and from being lifted off from the vessel ledge during reactor normal operation. Spring designer used to think under certain extreme operating conditions, the spring could be lifted off from the ledge because the spring is not stiff enough to prevent the “lift-off”. Therefore, the spring was designed as stiff as it practically can be. However, finite element study indicated that the magnitude of preload is a strong function of friction coefficient. To find the magnitude of the friction coefficient, a series of tests were conducted on 1/10 scale hold down spring samples of three different spring designs. From the test results, it was found that the friction coefficient increases rapidly as the number of loading cycles increases. This implies that the spring preload would increase rapidly during plant operation. Therefore, it is concluded that, because of the strong frictional effect, not only the current design is more than adequate, but also should be made even softer.

  11. 49 CFR 178.338-9 - Holding time.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Holding time. 178.338-9 Section 178.338-9... Specifications for Containers for Motor Vehicle Transportation § 178.338-9 Holding time. (a) “Holding time” is the time, as determined by testing, that will elapse from loading until the pressure of the...

  12. 26 CFR 1.563-2 - Personal holding company tax.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Personal holding company tax. 1.563-2 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Deduction for Dividends Paid § 1.563-2 Personal holding company tax. In the case of a personal holding company subject to the provisions of section 541, dividends paid...

  13. In vitro differentiation of human adipose-derived adult stromal cells into neuron-like cells in hippocampal astrocyte conditioned medium

    Institute of Scientific and Technical Information of China (English)

    Xinchun Ye; Hongjun He; Feng Yang; Kepeng Zhao; Jun Yao; Bin Liu

    2006-01-01

    BACKGROUND: At present, researches on differentiating from human adipose-derived adult stromal cells (hADASC) to neuron-like cells are focus on inducing by artificial-synthetic compound solution;however,hippocampal astrocyte conditioned medium(HCAM)can induce in vitro differentiation from hADASC to neuron-like cells is still unclear.OBJECTIVE:To observe whether HCAM can induce in vitro differentiation from hADASC to neuron-like cells.DESIGN:Randomized control study.SETTING:Department of Neurology,Taixing People's Hospital;Central Laboratory,North China Coal Medical College.MATERIALS:Donor of adipose tissue was donated by female volunteers suffering from caesarean section in the department of obstetrics & gynecology in our hospital and aged 20-35 years. Adipose tissue was collected from subcutaneous tissue of abdomen during the operation.In addition.8 male newborn Wistar rats within 24 hours with average body mass of 20 g were provided by Animal Institute of Chinese Academy of Medical Sciences.Rabbit-anti-human Nestin polyclonal antibody.Rabbit-anti-human glial fibriliary acidic protein (GFAP)polyclonal antibody, rabbit-anti-human neuro-specific enolase polyclonal antibody and mouse-anti-human microtubal associated protein 2(MAP-2)polyclonal antibody were provided by Wuhan Boster Company.METHODS:The experiment was carried out in the Central Laboratory of North China Coal Medical College from October 2004 to June 2005.hADASC was cultured with HCAM and its growth and morphological changes were observed under inverted phase contrast microscope.Immunocytochemistry.immunofluorescence and Western blotting were used to evaluate the expressions of Nestin,which was a specific sign of nerve precursor,neuro-specific enolase and MAP-2,which was a specific sign of nerve cell,and GFAP,which was a specific sign of neuroglial cells.MAIN OUTCOME MEASURES:Nestin,which was a specific sign of nerve precursor,neuro-specific enolase and MAP-2,which was a specific sign of nerve cell

  14. 77 FR 27855 - Celerity Partners IV, LLC, Celerity AHI Holdings SPV, LLC, and All Aboard America! Holdings, Inc...

    Science.gov (United States)

    2012-05-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Celerity Partners IV, LLC, Celerity AHI Holdings SPV, LLC, and All Aboard... SPV, LLC (Celerity Holdings), and Celerity Partners IV, LLC (Celerity Partners)...

  15. Adult learning in modernity

    DEFF Research Database (Denmark)

    Rasmussen, Palle

    2007-01-01

    The paper discusses the conditions for the growth of adult education in modern societies. It is argued that in modern adult life individual biographical reflection plays an increasing role, not only for educational and occupational choice but also in the process of identity formation and emotional...

  16. 78 FR 52391 - Supervision and Regulation Assessments for Bank Holding Companies and Savings and Loan Holding...

    Science.gov (United States)

    2013-08-23

    ... to prepare their financial statements in accordance with statutory accounting principles (SAP) and... Financial Statements for Bank Holding Companies (FR Y-9C); \\2\\ 12 U.S.C. 1841(a). A company that, on... the Board's use of generally accepted accounting principles (GAAP) in determining whether a company...

  17. A mathematical model of aerosol holding chambers

    DEFF Research Database (Denmark)

    Zak, M; Madsen, J; Berg, E;

    1999-01-01

    A mathematical model of aerosol delivery from holding chambers (spacers) was developed incorporating tidal volume (VT), chamber volume (Vch), apparatus dead space (VD), effect of valve insufficiency and other leaks, loss of aerosol by immediate impact on the chamber wall, and fallout of aerosol...... in the chamber with time. Four different spacers were connected via filters to a mechanical lung model, and aerosol delivery during "breathing" was determined from drug recovery from the filters. The formula correctly predicted the delivery of budesonide aerosol from the AeroChamber (Trudell Medical, London......-mentioned factors, initial loss of aerosol by impact on the chamber wall is most important for the efficiency of a spacer. With a VT of 195 mL, the AeroChamber and Babyhaler were emptied in two breaths, the NebuChamber in four breaths, and the Nebuhaler in six breaths. Insufficiencies of the expiratory valves were...

  18. Novelty-induced conditioned place preference, sucrose preference, and elevated plus maze behavior in adult rats after repeated exposure to methylphenidate during the preweanling period

    OpenAIRE

    Crawford, Cynthia A.; Der-Ghazarian, Taleen; Britt, Cynthia E.; Varela, Fausto A.; Kozanian, Olga O.

    2013-01-01

    Early treatment with methylphenidate has a persistent effect on the affective (i.e., anxiety- and depressive-like) behaviors of adult rats and mice. Interestingly, age at methylphenidate exposure appears to be a critical determinant influencing the expression of affective behaviors. In the present study, we exposed rats to methylphenidate during the preweanling period (i.e., PD 11-PD 20) because this ontogenetic period is analogous to early childhood in humans (an age associated with increasi...

  19. DOES UNCOVERED INTEREST RATE PARITY HOLD IN TURKEY?

    Directory of Open Access Journals (Sweden)

    Ozcan Karahan

    2012-01-01

    Full Text Available Most of the earlier empirical studies focusing on developed countries failed to give evidence in favor of the Uncovered Interest Rate Parity (UIP. After intensive financial liberalization processes and mostly preferred free exchange rate regimes, a new area of research starts to involve the investigation whether UIP holds for developing economies differently. Accordingly, we tested the UIP for Turkey’s monthly interest rate and exchange rate data between 2002 and 2011. We run conventional regressions in the form of Ordinary Least Squares (OLS and used a simple Generalized Autoregressive Conditional Heteroskedasticity (GARCH analysis. The empirical results of both methods do not support the validity of UIP for Turkey. Thus, together with most of the earlier empirical studies focusing on developed countries and detecting the invalidity of UIP, we can argue that the experience of Turkey and developed economies are not different.

  20. Anesthesia for Adults Having Eye Surgery

    Science.gov (United States)

    ... Conditions Frequently Asked Questions Español Condiciones Chinese Conditions Anesthesia for Adults Having Eye Surgery En Español What kinds of anesthesia are available for adults having eye surgery? A “ ...

  1. Effect of repetitive end-inspiration breath holding on very short-term heart rate variability in healthy humans

    International Nuclear Information System (INIS)

    Very short-term heart rate variability (HRV) is thought to reflect dynamic changes in autonomic nervous activity, which is helpful in understanding the role of autonomic nervous function (ANF) in the mechanisms underlying apnea-induced cardiac arrhythmias. The goal of this study was to investigate the effect of repetitive end-inspiration breath holding on very short-term HRV. A total of 32 young healthy participants took part in the experiments. Three trials were performed, each involving seven repetitive end-inspiration breath holding and a 30 s recovery period between breath holding. Durations of breath holding in the three trials were 1:2:3. The study first evaluated the effect of analyzed data lengths on the stability of HRV indices and determined three HRV indices suitable for very short-term analysis. The results showed that in most cases, during breath holding, the square root of the mean squared differences of successive normal RR intervals (rMSSD) was significantly lower, but normalized units of the power in the low frequency band ranging from 0.04 to 0.15 Hz (nLF) and LF/high frequency (HF) were significantly higher than those during corresponding durations under the normal breathing conditions. On the contrary, during recovery after breath holding, rMSSD was significantly higher but nLF and LF/HF were lower than normal. Moreover, the durations of breath holding had no significant influence on the variations of LF/HF. In addition, as participants repeated the breath holding, HRV indices varied non-linearly. HRV changes may indicate sympathetic activation during breath holding and parasympathetic activation during recovery after breath holding. In conjunction with the existing physiological interpretation based on changes in heart rate, the results may imply that breath holding leads to both cardiac sympathetic and parasympathetic activation simultaneously, which may be a possible pathogenic factor of apnea-induced arrhythmias. (paper)

  2. Mental models students hold of zoos

    Science.gov (United States)

    Patrick, Patricia Gail

    The purpose of this study was to depict the mental models high school students, ages 14-18, hold of zoos. This study also examined how students define conservation and the role of zoos in conservation. This study examined the differences in mental models of 84 students (1) 21 students who had visited a zoo with their teacher in the same semester in which the study was conducted, (2) 21 students who had visited a zoo during another school year with their teacher, (3) 21 students who had visited the zoo without a teacher, and (4) 21 students who had never visited a zoo. It also examined the mental models of students of different ethnicities and examined differences in mental models of young men and women. This study was conducted and the data analyzed using a qualitative methodology research design. All 84 students completed a demographic questionnaire, a concept map, and a ranking concepts exercise. Twenty-four students were interviewed. The findings indicated that: (1) students who had visited a zoo have a richer mental model of zoos than students who have never visited a zoo, (2) students who had visited a zoo with their teacher provided a deeper richer understanding of the roles of zoos in conservation and education, (3) students who have never visited a zoo do have mental models of zoos, (4) students do not mention conservation with respect to zoos unless specifically asked about the role of zoos in conservation, and (5) students did not mention the zoo's connection to species survival nor did they view zoos as a source of information for conservation-related topics. The data indicated that the mental models student hold of zoos consist of seven themes: (1) organisms, (2) people, (3) amenities, (4) descriptive terms, (5) habitats, (6) education, and (7) conservation. The seven themes were defined and used to create the Zoo Acuity Model. The central constructs of the Zoo Acuity Model are the Observation Framework, the Interaction Framework, and the Information

  3. Does combined cognitive training and physical activity training enhance cognitive abilities more than either alone? A four-condition randomized controlled trial among healthy older adults

    OpenAIRE

    Shatil, Evelyn

    2013-01-01

    Cognitive training and aerobic training are known to improve cognitive functions. To examine the separate and combined effects of such training on cognitive performance, four groups of healthy older adults embarked on a 4 months cognitive and/or mild aerobic training. A first group [n = 33, mean age = 80 (66–90)] engaged in cognitive training, a second [n = 29, mean age = 81 (65–89)] in mild aerobic training, a third [n = 29, mean age = 79 (70–93)] in the combination of both, and a fourth [n ...

  4. Does combined cognitive training and physical activity training enhance cognitive abilities more than either alone? A four-condition randomized controlled trial among healthy older adults

    OpenAIRE

    Evelyn Shatil

    2013-01-01

    Cognitive training and aerobic training are known to improve cognitive functions. To examine the separate and combined effects of such training on cognitive performance, four groups of healthy older adults embarked on a four months cognitive and/or mild aerobic training. A first group (n=33, mean age=80 [66-90]) engaged in cognitive training, a second (n=29, mean age=81 [65-89]) in mild aerobic training, a third (n=29, mean age=79 [70-93]) in the combination of both and a fourth (n=31, mean a...

  5. Influence of the section size and holding time on the graphite parameters of ductile iron production

    Directory of Open Access Journals (Sweden)

    S. Bockus

    2009-01-01

    Full Text Available This work was conducted to establish the conditions required to produce a desirable structure of the castings of various section sizes. This investigation was focused on the study of the influence of cooling rate or section size and holding time on graphite parameters of the ductile iron. Plates having thickness between 3 and 50mm were cast in sand molds using the same melt. The present investigation has shown that the section size of ductile iron castings and holding time had strong effect on the graphite parameters of the castings.

  6. The Determinants of International Portfolio Holdings and Home Bias

    OpenAIRE

    Shujing Li; Hamid Faruqee; Yan, Isabel K.

    2004-01-01

    Despite the liberalization of foreign portfolio investment around the globe since the early 1980s, the home-bias phenomenon is still found to exist. Using a relatively new IMF survey dataset of cross-border equity holdings, this paper tests new structural equations from a consumption-based asset-pricing model on international portfolio holdings. Using of stock data allows us to provide new and clear-cut evidence on the determinants of international portfolio holdings.

  7. The effect of acetazolamide on breath holding at high altitude.

    OpenAIRE

    Morrissey, S. C.; Keohane, K.; Coote, J.H.

    1987-01-01

    The effect of altitude and acetazolamide on breath holding was studied in 20 individuals. Breath holding time was reduced progressively during ascent. There was an additional reduction in the acetazolamide group at low but not at high altitude. The initial difference between the two groups may have been related to a lower CSF pH when on acetazolamide. At high altitude the finding of similar breath holding times in the two groups may have been due to acclimatization in the placebo group.

  8. Intangible Capital and Corporate Cash Holdings: Theory and Evidence

    OpenAIRE

    Dalida Kadyrzhanova; Antonio Falato; Jae Sim

    2012-01-01

    The rise in intangible capital is a fundamental driver of the secular trend in US corporate cash holdings over the last decades. We construct a new measure of intangible capital and show that intangible capital is the most important firm-level determinant of corporate cash holdings. Our measure accounts for almost as much of the secular increase in cash since the 1980s as all other standard determinants together. We then develop a new model of corporate cash holdings that introduces intangibl...

  9. Multiple-Job Holding Among Male Workers in Greece.

    OpenAIRE

    Livanos, Ilias; Zangelidis, Alexandros

    2008-01-01

    This paper studies the incidence of multiple job-holding in Greece and contributes to the literature by examining its determinants, its variance across different regions and the effect of the business cycle on its occurrence. The empirical analysis highlights the importance of both pecuniary and non-pecuniary motives behind multiple job-holding, and reveals significant variations in its incidence across regions, with areas that have a large primary sector having higher multiple job-holding ra...

  10. Cash Holdings, Corporate Governance Structure and Firm Valuation

    OpenAIRE

    Kin-Wai Lee; Cheng-Few Lee

    2009-01-01

    Firms with higher board independence, smaller boards, and lower expected managerial entrenchment, have lower cash holdings. We find that the positive association between cash holdings and managerial entrenchment is mitigated by stronger board structures. Specifically, in firms with higher expected managerial entrenchment, those with higher proportion of outside director on the board and smaller board size have lower cash holdings. We also find that firm value is negatively associated with cas...

  11. Progress Report on Long Hold Time Creep Fatigue of Alloy 617 at 850°C

    Energy Technology Data Exchange (ETDEWEB)

    Carroll, Laura Jill [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-10-01

    Alloy 617 is the leading candidate material for an intermediate heat exchanger for the very high temperature reactor. To evaluate the behavior of this material in the expected service conditions, strain-controlled cyclic tests that include long hold times up to 240 minutes at maximum tensile strain were conducted at 850°C. In terms of the total number of cycles to failure, the fatigue resistance decreased when a hold time was added at peak tensile strain. Increases in the tensile hold duration degraded the creep-fatigue resistance, at least to the investigated strain controlled hold time of up to 60 minutes at the 0.3% strain range and 240 minutes at the 1.0% strain range. The creep-fatigue deformation mode is considered relative to the lack of saturation, or continually decreasing number of cycles to failure with increasing hold times. Additionally, preliminary values from the 850°C creep-fatigue data are calculated for the creep-fatigue damage diagram and have higher values of creep damage than those from tests at 950°C.

  12. Progress Report on Long Hold Time Creep Fatigue of Alloy 617 at 850°C

    International Nuclear Information System (INIS)

    Alloy 617 is the leading candidate material for an intermediate heat exchanger for the very high temperature reactor. To evaluate the behavior of this material in the expected service conditions, strain-controlled cyclic tests that include long hold times up to 240 minutes at maximum tensile strain were conducted at 850°C. In terms of the total number of cycles to failure, the fatigue resistance decreased when a hold time was added at peak tensile strain. Increases in the tensile hold duration degraded the creep-fatigue resistance, at least to the investigated strain controlled hold time of up to 60 minutes at the 0.3% strain range and 240 minutes at the 1.0% strain range. The creep-fatigue deformation mode is considered relative to the lack of saturation, or continually decreasing number of cycles to failure with increasing hold times. Additionally, preliminary values from the 850°C creep-fatigue data are calculated for the creep-fatigue damage diagram and have higher values of creep damage than those from tests at 950°C.

  13. Height of Northern Jordanian middle-class adults, born 1960-1990 in the response to improving socio-economic conditions.

    Science.gov (United States)

    Abu Dalou, Ahmad Yosuf

    2016-09-01

    The purpose of this study is to document and explain secular trends in stature among Northern Jordanian men and women between the years of birth 1960 and 1990, as they relate to overall per capita socio-economic improvement, the stature of 360 adults from two Northern governorates, those of Jerash and Irbid, was measured. General linear model (GLM) was used to examine the effect of birth-decade, education level of subject, and their interaction on mean stature of each sex separately. GLM results revealed that women who were born during the following three decades pooled together (1951-1980) did not differ significantly in mean stature from those born during (1981-1990). Among men, stature of those born in the two pooled birth-decades together (1951-1970) did not significantly differ of those were born in the two pooled birth-decades (1971-1990). PMID:27130990

  14. Adult Education and Adult Learning

    DEFF Research Database (Denmark)

    Illeris, Knud

    Kort beskrivelse Bogen, 'Adult Education og Adult Learning', giver et fyldestgørende overblik over forståelsen af voksenuddannelse og læring. Abstract I "Adult Education and Adult Learning' ser Knud Illeris på voksenuddannelse fra to perspektiver. På den ene side beskrives de aktuelle udfordringer...

  15. Novel Findings in Breath-Holding Spells

    Science.gov (United States)

    Azab, Seham F.A.; Siam, Ahmed G.; Saleh, Safaa H.; Elshafei, Mona M.; Elsaeed, Wafaa F.; Arafa, Mohamed A.; Bendary, Eman A.; Farag, Elsayed M.; Basset, Maha A.A.; Ismail, Sanaa M.; Elazouni, Osama M.A.

    2015-01-01

    Abstract The mechanism of breath-holding spells (BHS) is not fully understood and most probably multifactorial; so, this study was designed to clarify the pathophysiology of BHS through assessing some laboratory parameters and electrocardiographic (ECG) changes which might be contributing to the occurrence of the attacks. Another aim of the study was to evaluate the differences in the pathophysiology between pallid and cyanotic types of BHS. This was a prospective study performed in Zagazig University Hospitals. Seventy-six children diagnosed with BHS were included as follows: 32 children with cyanotic BHS, 14 children with pallid BHS, and 30 healthy children as a control group. All children were subjected to the following: full history taking, clinical examination, and laboratory work up in the form of CBC, serum iron, ferritin, and zinc levels. Twenty-four hours ambulatory ECG (Holter) recording was also performed. No significant statistical difference was found between cyanotic and pallid groups regarding family history of BHS, severity, and precipitating factors of the attacks. Frequent runs of respiratory sinus arrhythmia (RSA) during 24 hours ECG were significantly higher in children with BHS; the frequency of RSA was significantly correlated with the frequency (severity) of the attacks. Low serum ferritin was significantly associated with BHS groups but not correlated with the severity of the attacks. Autonomic dysregulation evidenced by frequent RSA is considered to be an important cause of BHS in children and is correlated with the frequency of the attacks. Low serum ferritin is additional factor in the pathophysiology. Both pallid and cyanotic BHS are suggested to be types of the same disease sharing the same pathophysiology. PMID:26181556

  16. Keeping up appearances : The role of identity concealment in the workplace among adults with degenerative eye conditions and its relationship with wellbeing and career outcomes

    NARCIS (Netherlands)

    Spiegel, Tali; De Bel, Vera; Steverink, Nardi

    2016-01-01

    Purpose: This study aims to describe the interplay between the work trajectories and the passing patterns of individuals with degenerative eye conditions in different phases of their career, as well as the disease progression and the career and well-being outcomes associated with different works and

  17. Keeping up appearances: the role of identity concealment in the workplace among adults with degenerative eye conditions and its relationship with wellbeing and career outcomes

    NARCIS (Netherlands)

    Spiegel, Tali; De Bel, Vera; Steverink, Nardi

    2016-01-01

    Purpose: This study aims to describe the interplay between the work trajectories and the passing patterns of individuals with degenerative eye conditions in different phases of their career, as well as the disease progression and the career and well-being outcomes associated with different works and

  18. Early developed section of the jaw as an index of prenatal growth conditions in adult roe deer Capreolus capreolus

    DEFF Research Database (Denmark)

    Høye, Toke Thomas; Forchhammer, Mads Cedergreen

    2006-01-01

    -maturing bones are poor predictors of resource limitations during early development, as later benign conditions may lead to compensatory growth. We analysed the temporal growth dynamics of different sections of the lower jaw of roe deer Capreolus capreolus and found that the medioanterior section of the lower...

  19. Children's Participation in Preschool--On the Conditions of the Adults? Preschool Staff's Concepts of Children's Participation in Preschool Everyday Life

    Science.gov (United States)

    Sandberg, Anette; Eriksson, Anette

    2010-01-01

    The purpose of this study was to investigate, analyse and describe preschool staff's concepts of children's participation in everyday preschool life, as well as preschool staff's experiences and concepts of what characterises the children who participate. Furthermore, it addresses the conditions that preschool staff consider as crucial in…

  20. Air Conditioning and Refrigeration. Volume XXVI. 1975 Edition of Course of Study Outlines. Middlesex County Vocational and Technical High Schools and Middlesex County Adult Technical Schools.

    Science.gov (United States)

    Capizzi, James

    The two courses of study described and outlined here are offered at Burr D. Coe Vocational and Technical High School in East Brunswick, New Jersey, for students wishing to prepare for a career in air conditioning and refrigeration. Section 1 deals with a 4-year high school course, Section 2 with a 1-year course for those who have completed high…

  1. A Pilot Investigation regarding Speech-Recognition Performance in Noise for Adults with Hearing Loss in the FM+HA Listening Condition

    Science.gov (United States)

    Lewis, M. Samantha; Gallun, Frederick J.; Gordon, Jane; Lilly, David J.; Crandell, Carl

    2010-01-01

    While the concurrent use of the hearing aid (HA) microphone with frequency modulation (FM) technology can decrease speech-recognition performance, the FM+HA condition is still an important setting for users of both HA and FM technology. The primary goal of this investigation was to evaluate the effect of attenuating HA gain in the FM+HA listening…

  2. 31 CFR 223.16 - List of certificate holding companies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false List of certificate holding companies...) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE SURETY COMPANIES DOING BUSINESS WITH THE UNITED STATES § 223.16 List of certificate holding companies. A list of qualified companies...

  3. 76 FR 54717 - Supervised Securities Holding Companies Registration

    Science.gov (United States)

    2011-09-02

    ... company, the biographical information requested in the Interagency Biographical and Financial Report FR... Existing Information Collections: The Annual Report of Bank Holding Companies (FR Y-6), The Report of Foreign Banking Organizations (FR Y-7), The Consolidated Financial Statements for Bank Holding...

  4. Holdings of the Federal German Government in 1988

    International Nuclear Information System (INIS)

    The report provides an overview of the direct and more important indirect holdings of the Federal German Government and its special assets ERP, Compensation Fund, Federal Mail and Federal Railway. Part A provides a total survey of the number of government holdings. For the direct holdings of the Federal Government and its special assets the shares in nominal capital and registered foundation capital, number of employees and dividend on profits are presented. In Parts B to M, the narrative parts, the most important holdings are reported on more in detail (sphere of activities, economic development, composition of the corporate bodies). The listing order does not reflect any order of importance. The following part N contains alphabetic indexes. Indexes I and II list all the direct holdings of the Federal Government and its special assets irrespective of the nominal capital volume and share of holdings. In index III, are listed only companies with corporate activites and a nominal capital of at least 100.000 German Marks of which the Federal Government and/or its special assets hold directly or indirectly at least 25 percent. Holdings of these undertakings of which the Federal Government does not have majority ownership, and which are not dependent on it under the regulations governing shareholdings either, are not considered. (orig.)

  5. Reaching the Crossroads of Two Lists for Periodicals Holdings

    Science.gov (United States)

    Coombs, Karen A.

    2004-01-01

    As an information and instruction librarian at SUNY-Cortland, the author is responsible for designing, developing, and maintaining the Library's Web site. In this article, she describes her experience in combining print/microform holdings list. She pursued a strategy that would make the two holding lists "appear" as one by using XML. She iterates…

  6. Acute effects of cannabis on breath-holding duration.

    Science.gov (United States)

    Farris, Samantha G; Metrik, Jane

    2016-08-01

    Distress intolerance (an individual's perceived or actual inability to tolerate distressing psychological or physiological states) is associated with cannabis use. It is unknown whether a biobehavioral index of distress intolerance, breath-holding duration, is acutely influenced (increased or decreased) by cannabis. Such information may further inform understanding of the expression of psychological or physiological distress postcannabis use. This within-subjects study examined whether smoked marijuana with 2.7%-3.0% delta-9-tetrahydrocannabinol (THC), relative to placebo, acutely changed duration of breath holding. Participants (n = 88; 65.9% male) were nontreatment-seeking frequent cannabis users who smoked placebo or active THC cigarette on two separate study days and completed a breath-holding task postsmoking. Controlling for baseline breath-holding duration and participant sex, THC produced significantly shorter breath-holding durations relative to placebo. There was a significant interaction of drug administration × frequency of cannabis use, such that THC decreased breath-holding time among less frequent but not among more frequent users. Findings indicate that cannabis may exacerbate distress intolerance (via shorter breath-holding durations). As compared to less frequent cannabis users, frequent users display tolerance to cannabis' acute effects including increased ability to tolerate respiratory distress when holding breath. Objective measures of distress intolerance are sensitive to contextual factors such as acute drug intoxication, and may inform the link between cannabis use and the expression of psychological distress. (PsycINFO Database Record PMID:27454678

  7. Optimization of holding tank system for medical radioactive waste

    International Nuclear Information System (INIS)

    Holding tank systems are used for the disposal of medical radioactive waste. A short cut method including economic valuation work for the optimization of holding tank system is developed. A case study work was also performed via the developed method. The optimum tank arrangement for this case was found. (author)

  8. Holding Periods, Illiquidity and Disposition Effect in a Developing Economy

    Directory of Open Access Journals (Sweden)

    Muhammad Aftab,

    2012-01-01

    Full Text Available This paper aims to empirically investigate holding periods, illiquidity and disposition effect in Karachi Stock Exchange (KSE. KSE 100 Index Companies daily data were collected for a period of five year i.e. 2003-2007. Daily returns, holding periods, illiquidity and volatility were calculated through this data. These variables were regressed in models used by Visaltanachoti et al. (2007 to calculate annual holding periods, illiquidity and disposition effect. The results have revealed that there exists disposition effect in KSE. Holding periods were found positively related to illiquidity and negatively associated with stock returns. Further, holding periods were long for illiquid stocks and short for less illiquid stocks. The study is significant in the sense that it’s perhaps the first study conducted in a developing country like Pakistan.

  9. Impact of Cranial Irradiation Added to Intrathecal Conditioning in Hematopoietic Cell Transplantation in Adult Acute Myeloid Leukemia With Central Nervous System Involvement

    International Nuclear Information System (INIS)

    Purpose: Neither the prognostic importance nor the appropriate management of central nervous system (CNS) involvement is known for patients with acute myeloid leukemia (AML) undergoing hematopoietic cell transplantation (HCT). We examined the impact of a CNS irradiation boost to standard intrathecal chemotherapy (ITC). Methods and Materials: From 1995 to 2005, a total of 648 adult AML patients received a myeloablative HCT: 577 patients were CNS negative (CNS-), and 71 were CNS positive (CNS+). Of the 71 CNS+ patients, 52 received intrathecal chemotherapy alone (CNS+ITC), and 19 received ITC plus an irradiation boost (CNS+RT). Results: The CNS-, CNS+ITC, and CNS+RT patients had 1- and 5-year relapse-free survivals (RFS) of 43% and 35%, 15% and 6%, and 37% and 32%, respectively. CNS+ITC patients had a statistically significant worse RFS compared with CNS- patients (hazard ratio [HR], 2.65; 95% confidence interval [CI], 2.0-3.6; p < 0.0001). CNS+RT patients had improved relapse free survival over that of CNS+ITC patients (HR, 0.45; 95% CI, 0.2-0.8; p = 0.01). The 1- and 5-year overall survivals (OS) of patients with CNS-, CNS+ITC, and CNS+RT, were 50% and 38%, 21% and 6%, and 53% and 42%, respectively. The survival of CNS+RT were significantly better than CNS+ITC patients (p = 0.004). After adjusting for known risk factors, CNS+RT patients had a trend toward lower relapse rates and reduced nonrelapse mortality. Conclusions: CNS+ AML is associated with a poor prognosis. The role of a cranial irradiation boost to intrathecal chemotherapy appears to mitigate the risk of CNS disease, and needs to be further investigated to define optimal treatment strategies.

  10. Sex differences in the effects of ethanol pre-exposure during adolescence on ethanol-induced conditioned taste aversion in adult rats

    OpenAIRE

    Sherrill, Luke K.; Berthold, Claire; Koss, Wendy A.; Juraska, Janice M.; Gulley, Joshua M.

    2011-01-01

    Alcohol use, which typically begins during adolescence and differs between males and females, is influenced by both the rewarding and aversive properties of the drug. One way adolescent alcohol use may modulate later consumption is by reducing alcohol s aversive properties. Here, we used a conditioned taste aversion (CTA) paradigm to determine if pre-exposure to alcohol (ethanol) during adolescence would attenuate ethanol-induced CTA assessed in adulthood in a sex-dependent manner. Male and f...

  11. Sex differences in the effects of ethanol pre-exposure during adolescence on ethanol-induced conditioned taste aversion in adult rats.

    Science.gov (United States)

    Sherrill, Luke K; Berthold, Claire; Koss, Wendy A; Juraska, Janice M; Gulley, Joshua M

    2011-11-20

    Alcohol use, which typically begins during adolescence and differs between males and females, is influenced by both the rewarding and aversive properties of the drug. One way adolescent alcohol use may modulate later consumption is by reducing alcohol's aversive properties. Here, we used a conditioned taste aversion (CTA) paradigm to determine if pre-exposure to alcohol (ethanol) during adolescence would attenuate ethanol-induced CTA assessed in adulthood in a sex-dependent manner. Male and female Long-Evans rats were given intraperitoneal (i.p.) injections of saline or 3.0g/kg ethanol in a binge-like pattern during postnatal days (PD) 35-45. In adulthood (>PD 100), rats were given access to 0.1% saccharin, followed by saline or ethanol (1.0 or 1.5g/kg, i.p.), over four conditioning sessions. We found sex differences in ethanol-induced CTA, with males developing a more robust aversion earlier in conditioning. Sex differences in the effects of pre-exposure were also evident: males, but not females, showed an attenuated CTA in adulthood following ethanol pre-exposure, which occurred approximately nine weeks earlier. Taken together, these findings indicate that males are more sensitive to the aversive properties of ethanol than females. In addition, the ability of pre-exposure to the ethanol US to attenuate CTA is enhanced in males compared to females. PMID:21767576

  12. Common Conditions in Newborns

    Science.gov (United States)

    ... Prenatal Baby Bathing & Skin Care Breastfeeding Crying & Colic Diapers & Clothing Feeding & Nutrition Preemie Sleep Teething & Tooth Care Toddler Preschool Gradeschool Teen Young Adult Healthy Children > Ages & Stages > Baby > Common Conditions in ...

  13. Role of cerebral blood flow in extreme breath holding

    Directory of Open Access Journals (Sweden)

    Bain Anthony R.

    2016-01-01

    Full Text Available The role of cerebral blood flow (CBF on a maximal breath-hold (BH in ultra-elite divers was examined. Divers (n = 7 performed one control BH, and one BH following oral administration of the non-selective cyclooxygenase inhibitor indomethacin (1.2 mg/kg. Arterial blood gases and CBF were measured prior to (baseline, and at BH termination. Compared to control, indomethacin reduced baseline CBF and cerebral delivery of oxygen (CDO2 by about 26% (p < 0.01. Indomethacin reduced maximal BH time from 339 ± 51 to 319 ± 57 seconds (p = 0.04. In both conditions, the CDO2 remained unchanged from baseline to the termination of apnea. At BH termination, arterial oxygen tension was higher following oral administration of indomethacin compared to control (4.05 ± 0.45 vs. 3.44 ± 0.32 kPa. The absolute increase in CBF from baseline to the termination of apnea was lower with indomethacin (p = 0.01. These findings indicate that the impact of CBF on maximal BH time is likely attributable to its influence on cerebral H+ washout, and therefore central chemoreceptive drive to breathe, rather than to CDO2.

  14. Higher Early Monocyte and Total Lymphocyte Counts Are Associated with Better Overall Survival after Standard Total Body Irradiation, Cyclophosphamide, and Fludarabine Reduced-Intensity Conditioning Double Umbilical Cord Blood Allogeneic Stem Cell Transplantation in Adults.

    Science.gov (United States)

    Le Bourgeois, Amandine; Peterlin, Pierre; Guillaume, Thierry; Delaunay, Jacques; Duquesne, Alix; Le Gouill, Steven; Moreau, Philippe; Mohty, Mohamad; Campion, Loïc; Chevallier, Patrice

    2016-08-01

    This single-center retrospective study aimed to report the impact of early hematopoietic and immune recoveries after a standard total body irradiation, cyclophosphamide, and fludarabine (TCF) reduced-intensity conditioning (RIC) regimen for double umbilical cord blood (dUCB) allogeneic stem cell transplantation (allo-SCT) in adults. We analyzed 47 consecutive patients older than 17 years who engrafted after a dUCB TCF allo-SCT performed between January 2006 and April 2013 in our department. Median times for neutrophil and platelet recoveries were 17 (range, 6 to 59) and 37 days (range, 0 to 164), respectively. The 3-year overall (OS) and disease-free survivals, relapse incidence, and nonrelapse mortality were 65.7%, 57.2%, 27.1%, and 19%, respectively. In multivariate analysis, higher day +30 monocyte (≥615/mm(3); hazard ratio [HR], .04; 95% confidence interval [CI], .004 to .36; P < .01) and day +42 lymphocyte (≥395/mm(3); HR, .16; 95% CI, .03 to .78; P = .02) counts were independently associated with better OS. These results suggest that early higher hematopoietic and immune recovery is predictive of survival after dUCB TCF RIC allo-SCT in adults. Factors other than granulocyte colony-stimulating factor, which was used in all cases, favoring expansion of monocytes or lymphocytes, should be tested in the future as part of the UCB transplantation procedure. PMID:27118570

  15. An insulin based model to explain changes and interactions in human breath-holding.

    Science.gov (United States)

    Dangmann, Rosita

    2015-06-01

    Until now oxygen was thought to be the leading factor of hypoxic conditions. Whereas now it appears that insulin is the key regulator of hypoxic conditions. Insulin seems to regulate the redox state of the organism and to determine the breakpoint of human breath-holding. This new hypoxia-insulin hypotheses might have major clinical relevance. Besides the clinical relevance, this hypothesis could explain, for the first time, why the training of the diaphragm, among other factors, results in an increase in breath-holding performance. Elite freedivers/apnea divers are able to reach static breath-holding times to over 6 min. Untrained persons exhibit an unpleasant feeling after more or less a minute. Breath-holding is stopped at the breakpoint. The partial oxygen pressure as well as the carbon dioxide pressure failed to directly influence the breakpoint in earlier studies. The factors that contribute to the breakpoint are still under debate. Under hypoxic conditions the organism needs more glucose, because it changes from the oxygen consuming pentose phosphate (36 ATP/glucose molecule) to the anaerobic glycolytic pathway (2ATP/glucose molecule). Hence insulin, as it promotes the absorption of glucose, is set in the center of interest regarding hypoxic conditions. This paper provides an insulin based model that could explain the changes and interactions in human breath-holding. The correlation between hypoxia and reactive oxygen species (ROS) and their influence on the sympathetic nerve system and hypoxia-inducible factor 1 alpha (HIF-1α) is dealt with. It reviews as well the direct interrelation of HIF-1α and insulin. The depression of insulin secretion through the vagus nerve activation via inspiration is discussed. Furthermore the paper describes the action of insulin on the carotid bodies and the diaphragm and therefore a possible role in respiration pattern. Freedivers that go over the breakpoint of breath-holding could exhibit seizures and thus the effect of

  16. Cash holdings of German open-end equity funds: Does ownership matter?

    OpenAIRE

    Dötz, Niko; Weth, Mark

    2013-01-01

    In the light of the recent financial crisis, the discussion on the nature of runs and on the stabilizing role of liquidity holdings has intensified. This paper explores the cash management conducted by German open-end equity funds for the period between 2005 and 2010. Since ownership structures may have important consequences according to recent work, we distinguish funds whose shares are predominantly held by retail investors from funds with a stronger institutional orientation. Conditional ...

  17. FUNCTIONING OF AGRICULTURAL HOLDINGS IN UKRAINE: STRONG AND WEAK SIDES

    Directory of Open Access Journals (Sweden)

    Postgraduate, assistant Sergii Ivanovich TODORIUK

    2014-06-01

    Full Text Available One of the organizational forms of the agricultural management which is gaining popularity in the world is agricultural holdings. The essence of agricultural holdings is considered in the article. Also the peculiarities of their functioning in Ukraine and determination of the strengths and weaknesses of their activities is defined, as well as perspectives of their further functioning. Agrarian holding, as a relatively new organizational legal form of managing in Ukraine has its advantages and disadvantages. As the experience shows the advantages of agrarian holdings over the subjects of management are revealed mainly in the economic sphere. While their disadvantages over the subjects of management are revealed in social and ecological spheres. This is a negative moment considering the implementation in Ukraine of the concept of the sustainable development, which means the combination of these main components (economic component, environmental component, social component.

  18. Gut Bacteria May Hold Clues to Chronic Fatigue Syndrome

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_159905.html Gut Bacteria May Hold Clues to Chronic Fatigue Syndrome Intestinal ... doctors -- may be influenced by a person's intestinal bacteria -- sometimes called gut microbiome, new research finds. "Patients ...

  19. Veterinary students to hold community dog wash April 10

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Veterinary students enrolled in the Virginia-Maryland Regional College of Veterinary Medicine will hold a community dog wash on Saturday, April 10 from 8 a.m. to 3 p.m. on Virginia Tech's Blacksburg campus.

  20. Patent holdings of US biotherapeutic companies in major markets.

    Science.gov (United States)

    Sebastian, Teena E; Yerram, Chandra Bindu; Saberwal, Gayatri

    2009-05-01

    In previous studies we examined the (United States, US) patent holdings of 109 largely North American biotech companies developing therapeutics that, in particular, have an interest in discovery stage science. There appears little correlation between the number of patents and the number of products of individual companies. Here we quantified and compared the 103 US-headquartered companies' patent holdings in Australia, Canada, Europe, Japan and the US. The companies demonstrate variable and surprising patterns of patent holdings across these countries or regions. For most companies, patent holdings are not in proportion to the importance of the country as a biotech or pharma market. These results have implications for the patenting strategies of small biotech companies involved in drug discovery. PMID:19429502

  1. ENERGY STAR Certified Commercial Hot Food Holding Cabinet

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 2.0 ENERGY STAR Program Requirements for Commercial Hot Food Holding Cabinets that are...

  2. The Hold-up Problem Under Common Agency

    OpenAIRE

    Antonio Nicita; Simone Sepe

    2012-01-01

    Many real world transactions occur in a common agency environment in which an agent interacts with several principals having competing interests. The hold-up literature, however, has so far neglected to investigate common agency transactions. In this paper, we consider the hold-up problem that arises in a context where there are a monopolistic seller and multiple buyers on the one side and all the parties on the other are required to make specific self-investments. Our contribution is twofold...

  3. Impact of breath holding on cardiovascular respiratory and cerebrovascular health.

    Science.gov (United States)

    Dujic, Zeljko; Breskovic, Toni

    2012-06-01

    Human underwater breath-hold diving is a fascinating example of applied environmental physiology. In combination with swimming, it is one of the most popular forms of summer outdoor physical activities. It is performed by a variety of individuals ranging from elite breath-hold divers, underwater hockey and rugby players, synchronized and sprint swimmers, spear fishermen, sponge harvesters and up to recreational swimmers. Very few data currently exist concerning the influence of regular breath holding on possible health risks such as cerebrovascular, cardiovascular and respiratory diseases. A literature search of the PubMed electronic search engine using keywords 'breath-hold diving' and 'apnoea diving' was performed. This review focuses on recent advances in knowledge regarding possibly harmful physiological changes and/or potential health risks associated with breath-hold diving. Available evidence indicates that deep breath-hold dives can be very dangerous and can cause serious acute health problems such a collapse of the lungs, barotrauma at descent and ascent, pulmonary oedema and alveolar haemorrhage, cardiac arrest, blackouts, nitrogen narcosis, decompression sickness and death. Moreover, even shallow apnoea dives, which are far more frequent, can present a significant health risk. The state of affairs is disturbing as athletes, as well as recreational individuals, practice voluntary apnoea on a regular basis. Long-term health risks of frequent maximal breath holds are at present unknown, but should be addressed in future research. Clearly, further studies are needed to better understand the mechanisms related to the possible development or worsening of different clinical disorders in recreational or competitive breath holding and to determine the potential changes in training/competition regimens in order to prevent these adverse events. PMID:22574634

  4. The carbon holdings of northern Ecuador's mangrove forests

    OpenAIRE

    Hamilton, Stuart E.; Lovette, John; Borbor, Mercy; Millones, Marco

    2016-01-01

    Within a GIS environment, we combine field measures of mangrove diameter, mangrove species distribution, and mangrove density with remotely sensed measures of mangrove location and mangrove canopy cover to estimate the mangrove carbon holdings of northern Ecuador. We find that the four northern estuaries of Ecuador contain approximately 7,742,999 t (plus or minus 15.47 percent) of standing carbon. Of particular high carbon holdings are the Rhizophora mangle dominated mangrove stands found in-...

  5. De determinanten van cash holdings bij Belgische KMO's

    OpenAIRE

    Vanbaelen, Niels

    2011-01-01

    Deze eindverhandeling handelt over de determinanten die een invloed kunnen hebben op het niveau van cash holdings van Belgische KMO's. Dit werkstuk beslaat zeven hoofdstukken. Eerst en vooral wordt de probleemstelling uitgewerkt in hoofdstuk één gevolgd door een definiëring van het begrip KMO in hoofdstuk twee. Vervolgens komt in hoofdstuk drie een uitgebreide literatuurstudie aan bod. In hoofdstuk vier worden de determinanten van de cash holdings besproken, welke uit de literatuurstudie voor...

  6. INNOVATION DEVELOPMENT MANAGEMENT IN VERTICALLY INTEGRATED HOLDING COMPANY

    OpenAIRE

    Uspenskaja, N.

    2015-01-01

    The trend towards production consolidation and integration processes taking place both in the Russian and global economies leads to development of business associations, with a holding company being the most common form in Russia and around the globe. The evidence in favor of the formation of holding companies is that they can benefit from the scale (bulk purchasing, centralized stuff training); in the global capital and exports markets they can be more effective than smaller businesses and, ...

  7. Breath-hold CT attenuation correction for quantitative cardiac SPECT

    OpenAIRE

    Koshino, Kazuhiro; Fukushima, Kazuhito; Fukumoto, Masaji; Sasaki, Kazunari; Moriguchi, Tetsuaki; Hori, Yuki; Zeniya, Tsutomu; Nishimura, Yoshihiro; Kiso, Keisuke; Iida, Hidehiro

    2012-01-01

    Background Attenuation correction of a single photon emission computed tomography (SPECT) image is possible using computed tomography (CT)-based attenuation maps with hybrid SPECT/CT. CT attenuation maps acquired during breath holding can be misaligned with SPECT, generating artifacts in the reconstructed images. The purpose of this study was to investigate the effects of respiratory phase during breath-hold CT acquisition on attenuation correction of cardiac SPECT imaging. Methods A series o...

  8. 同性恋者精神健康相关问题%MENTAL HEALTH CONDITION OF GAY AND LESBIAN IN ADULTS AND ADOLESCENTS

    Institute of Scientific and Technical Information of China (English)

    杨峘; 张亚林

    2011-01-01

    When one's sexual orientation absolutely or mainly pointed to the same sex, this phenomenon called homosexuality. People with same sexual orientation faced much more pressure and discrimination, but they hardly been accepted by our society and barely got social support. They were also often been connected with negative social events while few people concern their mental health. Adolescents with same sex orientation were especially vulnerable groups, because they were in important period of both growth and sexual orientation improvement. This article is trying to discuss the epidemiology and mental health problems of these people, and overview their mental health condition.%某一个体的性欲完全或主要指向同性时,这一现象和个体分别称同性恋和同性恋者.同性恋作为客观存在的事实依然很难被人们接受,同性恋者也常常受到歧视,面临着比主流人群更多的压力,却很少能得到社会支持.人们总是将这部分人群与不良的社会现象联系起来,却很少关注他们的精神健康状况.尤其是青少年同性恋者,作为处于生长发育关键时期并有着非主流的性取向的特殊人群,更是值得关注的弱势群体.本文试图通过对同性恋者和青少年同性恋者的流行学及其精神卫生相关问题进行综述,以现其精神健康状况.

  9. Trunk muscle fatigue during a lateral isometric hold test: what are we evaluating?

    Directory of Open Access Journals (Sweden)

    Pagé Isabelle

    2012-04-01

    Full Text Available Abstract Background Side bridge endurance protocols have been suggested to evaluate lateral trunk flexor and/or spine stabilizer muscles. To date, no study has investigated muscle recruitment and fatigability during these protocols. Therefore the purpose of our study was to quantify fatigue parameters in various trunk muscles during a modified side bridge endurance task (i.e. a lateral isometric hold test on a 45° roman chair apparatus and determine which primary trunk muscles get fatigued during this task. It was hypothesized that the ipsilateral external oblique and lumbar erector spinae muscles will exhibit the highest fatigue indices. Methods Twenty-two healthy subjects participated in this study. The experimental session included left and right lateral isometric hold tasks preceded and followed by 3 maximal voluntary contractions in the same position. Surface electromyography (EMG recordings were obtained bilaterally from the external oblique, rectus abdominis, and L2 and L5 erector spinae. Statistical analysis were conducted to compare the right and left maximal voluntary contractions (MVC, surface EMG activities, right vs. left holding times and decay rate of the median frequency as the percent change from the initial value (NMFslope. Results No significant left and right lateral isometric hold tests differences were observed neither for holding times (97.2 ± 21.5 sec and 96.7 ± 24.9 sec respectively nor for pre and post fatigue root mean square during MVCs. However, participants showed significant decreases of MVCs between pre and post fatigue measurements for both the left and right lateral isometric hold tests. Statistical analysis showed that a significantly NMFslope of the ipsilateral external oblique during both conditions, and a NMFslope of the contralateral L5 erector spinae during the left lateral isometric hold test were steeper than those of the other side’s respective muscles. Although some participants

  10. Adult medulloblastoma.

    OpenAIRE

    Pobereskin, L; Treip, C

    1986-01-01

    Twelve cases of adult onset medulloblastoma are presented. Clinical features, treatment and outcome are discussed. It was found that the survival rates for adults are no better than for children. There were no clinical or histological features that distinguished these tumours from those occurring in childhood, except for a higher incidence of hemisphere lesions.

  11. High voltage pulse conditioning

    Science.gov (United States)

    Springfield, Ray M.; Wheat, Jr., Robert M.

    1990-01-01

    Apparatus for conditioning high voltage pulses from particle accelerators in order to shorten the rise times of the pulses. Flashover switches in the cathode stalk of the transmission line hold off conduction for a determinable period of time, reflecting the early portion of the pulses. Diodes upstream of the switches divert energy into the magnetic and electrostatic storage of the capacitance and inductance inherent to the transmission line until the switches close.

  12. Cyclic Creep Behavior with Hold Time under Tension-Tension Loading Cycles of Grade 91 Steel

    International Nuclear Information System (INIS)

    Cyclic deformation behavior is very important in practice because the high-temperature structural components are exposed under the cyclic conditions of repeated loading. In the case of static creep (SC), the response of the material is simple as a static state of monotonic loading. However, in the case of cyclic creep (CC), it is complex because of a dynamic loading. So far, cyclic creep data have been rarely reported and it has not been understood well whether the cyclic creep will accelerate or retard the creep rate and creep life compared with static creep, because not only is the plastic deformation under cyclic loading drastically different from that under monotonic loading, but the cyclic creep response is also dependent on the cycling frequency, stress range, stress ratio, and hold period of cycling. Therefore, it is necessary to clarify the cyclic creep behavior influencing the creep deformation and fracture process. The cyclic creep behavior for Gr, 91 steel was investigated from a series of cyclic creep tests which was performed with various hold times and stress ratios under tension-tension loading cycles. The results showed that at the test conditions of the short hold time (HT=1 and 3 min) and higher stress ratios (R=0.90 and 0.95), the cyclic rupture time increased sharply and the creep rate decreased largely

  13. Changing medical students' attitudes toward older adults.

    Science.gov (United States)

    Gonzales, Ernest; Morrow-Howell, Nancy; Gilbert, Pat

    2010-01-01

    Given the growth in the number of older adults and the ageist attitudes many in the health care profession hold, interventions aimed at improving health professionals' attitudes toward older adults are imperative. Vital Visionaries is an intergenerational art program designed to improve medical students' attitudes toward older adults. Participants met for four 2-hour sessions at local art museums to create and discuss art. Three hundred and twenty-eight individuals (112 treatment group, 96 comparison, 120 older adults) in eight cities participated in the program and evaluation. Participants completed pre-and postsurveys that captured their attitude toward older adults, perception of commonality with older adults, and career plans. Findings suggest that medical students' attitudes toward old adults were positive at pretest. However, Vital Visionary students became more positive in their attitudes toward older adults at posttest (p career plans (p = .35). Findings from this demonstration project suggest that socializing medical students with healthy older adults through art programs can foster positive attitudes and enhance their sense of commonality with older adults. PMID:20730650

  14. Reasons for holding a Consensus Conference on neuropsychological rehabilitation in adult patients.

    Science.gov (United States)

    Làdavass, E; Paolucci, S; Umiltà, C

    2011-03-01

    Neuropsychological deficits are common in various cerebrovascular, neurodegenerative and traumatic pathologies. Neuropsychological rehabilitation refers to a set of interventions that aim to improve a person's ability to perform cognitive tasks by retraining previously learned skills and teaching compensatory strategies. However, today there are some relevant points that need of further investigations. In 2007, a Task Force was set up under the auspices of several scientific societies that operate in the field of psychology, neuropsychology, rehabilitation and neurology (AIP, GIRN, SIMFER, SIN, SINP, and SPAN) with the aim to clarify the theoretical background of neuropsychological rehabilitation and to assess the diagnostic instruments and the treatments available to date. This consensus conference (CC), using methods derived from those of Evidence-Based-Medicine (EMB), evaluated several points, including: a) legal aspects; b) epidemiological aspects; c) neuropsychological rehabilitation of attentional and executive disorders; d) neuropsychological rehabilitation of speech/language disorders; e) neuropsychological rehabilitation of visual field defects; f) neuropsychological rehabilitation of neglect; g) neuropsychological rehabilitation of memory disorders; h) cognitive rehabilitation of arm apraxia; i) neuropsychological rehabilitation of Alzheimer disease; j) rehabilitation of multiple sclerosis; k) rehabilitation of severe brain injuries; l) rehabilitation of mild to moderate brain injuries; m) rehabilitation of behavioral disorders in severe brain injuries. Then, CC submitted to a specific Jury a final report with summary tables and questions. The final meeting of the Jury was held in Siena in February 2010. PMID:21448122

  15. The Effects of Mothers' Past Infant-Holding Preferences on Their Adult Children's Face Processing Lateralisation

    Science.gov (United States)

    Vervloed, Mathijs P. J.; Hendriks, Angelique W.; van den Eijnde, Esther

    2011-01-01

    Face processing development is negatively affected when infants have not been exposed to faces for some time because of congenital cataract blocking all vision (Le Grand, Mondloch, Maurer, & Brent, 2001). It is not clear, however, whether more subtle differences in face exposure may also have an influence. The present study looked at the effect of…

  16. Analysis of Hold Down Force for IVTM in PGSFR

    International Nuclear Information System (INIS)

    The PGSFR (Prototype Generation IV Sodium Cooled Fast Reactor) is a new design for a compact sodium-cooled fast nuclear reactor. The main components of the IVTM (In-Vessel Transfer Machine) for PGSFR are composed of the upper driving part, the main tube and the pantograph arm including the gripper. The bottom of the pantograph arm has a tapered feature machined into it at the interface where it contacts the surrounding core assemblies when the hold down is engaged. A tapered feature on the core hold down assembly engages features in the top of the core assemblies and may help to reduce the deflections at the bottom of the main structural support tube while under refueling loads. Hold down force is one of the most important parameter for design IVTM. Elastic FE analysis was performed to calculate hold down force and displacement. The hold down force and displacement are 3626.8 N and -2.27 mm, respectively. The calculated values will be used to design IVTM for PGSFR. The maximum reaction force of fuel assembly is 641.05 N. The calculated values will be used to design receptacle and lower grid plate for PGSFR

  17. Diabetes: Unique to Older Adults

    Science.gov (United States)

    ... Glaucoma High Blood Pressure Managing Multiple Health Problems Pain Management Peripheral ... section provides information to help older adults and their caregivers consider their disease or condition in conjunction with ...

  18. Liver Disease and Adult Vaccination

    Science.gov (United States)

    ... and click "GO" or visit Healthmap Vaccine Finder . Liver Disease and Adult Vaccination Recommend on Facebook Tweet ... critical for people with health conditions such as liver disease. If you have chronic liver disease, talk ...

  19. Mind-body relationships in elite apnea divers during breath holding: a study of autonomic responses to acute hypoxemia

    OpenAIRE

    Laurino, Marco; Menicucci, Danilo; Mastorci, Francesca; Allegrini, Paolo; Piarulli, Andrea; Scilingo, Enzo P.; Bedini, Remo; Pingitore, Alessandro; Passera, Mirko; L'Abbate, Antonio; Gemignani, Angelo

    2012-01-01

    The mental control of ventilation with all associated phenomena, from relaxation to modulation of emotions, from cardiovascular to metabolic adaptations, constitutes a psychophysiological condition characterizing voluntary breath-holding (BH). BH induces several autonomic responses, involving both autonomic cardiovascular and cutaneous pathways, whose characterization is the main aim of this study. Electrocardiogram and skin conductance (SC) recordings were collected from 14 elite divers duri...

  20. Step 8: Encourages All Mothers, Families to Touch, Hold, Breastfeed, Care for Their Babies: The Coalition for Improving Maternity Services:

    OpenAIRE

    Storton, Sharon

    2007-01-01

    Step 8 of the Ten Steps to Mother-Friendly Care encourages all mothers and families, including those with sick or premature newborns or infants with congenital problems, to touch, hold, breastfeed, and care for their babies to the extent compatible with their conditions. The rationales for compliance with the step and systematic review are presented.

  1. Skin Conditions

    Science.gov (United States)

    Your skin is your body's largest organ. It covers and protects your body. Your skin Holds body fluids in, preventing dehydration Keeps harmful ... it Anything that irritates, clogs, or inflames your skin can cause symptoms such as redness, swelling, burning, ...

  2. Reactor internals and hold down spring stiffness/reaction calculation

    International Nuclear Information System (INIS)

    Background: Hold down spring is a structural component that supports the reactor pressure vessel. It is located between the flange and barrel components, and has a function that transfers the force caused by reactor pressure vessel cap to barrel flange. Purpose: This paper attempts to have an analysis calculation and comparison of AP1OOO and LPP Hold down spring. Methods: This article inherited Qinshan nuclear power hold down spring analysis method, use analytical method and FEM method to solve the problem. Results: The stress and deflection of HDS are calculated. Since the friction coefficient may have a large effect, the results of different friction coefficients are also analyzed. Conclusions: This paper compared the Qinshan, AP1000 and LPP HDS design advantages and disadvantages and proposed two kinds of new design, expected to have a reference value for follow-up engineers. (authors)

  3. C-14/I-29 Preservation and Hold Time Survey

    Energy Technology Data Exchange (ETDEWEB)

    Kitchen, S. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-04-08

    Preservation and hold time of radionuclides must account for both nuclear half-lives and nonnuclear loss mechanisms, but variations in the latter are often neglected. Metals-based defaults are inappropriate for long-lived non-metals C-14 and I-129, which are vulnerable to chemical and biological volatilization. Non-acidification is already widely practiced for them. Recommended addition measures from radiological and chemical literature include glass containers where possible, water filtration where possible, headspace minimization, light shielding, cold (4°C) storage and unfiltered water hold time of 28 days. Soil hold time may need to be shortened when water-logged, excessively sandy, or still adjusting to significant new contamination.

  4. Internationalization and Corporate Cash Holdings: Evidence from Brazil and Mexico

    Directory of Open Access Journals (Sweden)

    Newton Arata

    2015-05-01

    Full Text Available This research expands on previous studies of cash holdings and their determinants by studying the relationship between the degree of internationalization and the level of corporate cash holdings. We used a sample of nonfinancial, publicly traded companies from Brazil and Mexico for the period from 2006 to 2010. Our results suggest that the degree of internationalization is a determinant of cash, and that cash holding increases quadratically as the degree of company internationalization grows. Such behavior was different from the North American company studies in Chiang and Wang (2011. Similar to previous studies, both Trade-off and Pecking Order predictions are relevant control variables in our model. Finally, companies held less cash on their balance sheets during the precrisis period.

  5. Care of Adult Refugees with Chronic Conditions.

    Science.gov (United States)

    Terasaki, Genji; Ahrenholz, Nicole Chow; Haider, Mahri Z

    2015-09-01

    Refugees share a common experience of displacement from their country of origin, migration, and resettlement in an unfamiliar country. More than 17 million people have fled their home countries due to war, generalized violence, and persecution. US primary care physicians must care for their immediate and long-term medical needs. Challenges include (1) language and cultural barriers, (2) high rates of mental health disorders, (3) higher prevalence of latent infections, and (4) different explanatory models for chronic diseases. This article discusses management strategies for common challenges that arise in the primary care of refugees. PMID:26320045

  6. Adult teachers

    DEFF Research Database (Denmark)

    Larsen, Lea Lund

    2011-01-01

    In this paper I examine the research into the process of adult teachers’ practice-based learning as a part of an on-going project titled “Competence development through practice-based learning – a study of adult teacher’s learning processes”. The project relies on the notion of the adult teacher as...... a 'reflective practitioner’, who develops 'the language of practice’, through experience and learns when she is exposed to 'disjuncture’. Research done on continuing professional development and the inquiries done in the field of teacher thinking and within this the research on novices becoming...

  7. PETRA - The Licence Holding Model. PETRA working paper no. 4

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    The licence-holding status of individual family members is a significant factor in decisions over modal choice for particular journeys, for all members of the family. It is also a central factor in describing the car ownership status of the family. This paper present the disaggregate drivers licence holding model, LICENCE, which assigns licences to the individual members of the family in the PETRA model system. The assignment is based on the specific characteristics of the individual members, and relies on cross-sectional data. (au)

  8. Self-control, financial literacy & the co-holding puzzle

    OpenAIRE

    Gathergood, John; Weber, Jörg

    2014-01-01

    We use UK survey data to analyze the puzzling co-existence of high cost revolving consumer credit alongside low yield liquid savings in household balance sheets, which we name the ‘co-holding puzzle'. Approximately 12% of households in our sample co-hold, on average, £3800 of revolving consumer credit on which they incur interest charges, even though they could immediately pay down all this debt using their liquid assets. Co-holders are typically more financially literate, with above average ...

  9. Internal capital market efficiency of Belgian holding companies

    OpenAIRE

    Gautier, Axel; Malika HAMADI

    2004-01-01

    In this paper, we raise the following two questions. (1) Do Belgian holding companies operate an internal capital market to transfer financial resources amongst their subsidiaries? And if yes, (2) is the internal capital market efficient? To answer the first question, we check if group cash flow is a determinant of the group members investment spending. The answer is positive if the holding company’s subsidiary is affiliated to a coordination center and negative otherwise. To ans...

  10. Holding Pressure and Its Influence on Quality in PIM Technology

    Directory of Open Access Journals (Sweden)

    Pavel Petera

    2012-01-01

    Full Text Available The PIM (powder injection molding process consists of several steps in which faults can occur. The quality of the part that is produced usually cannot be seen until the end of the process. It is therefore necessary to find a way to discover the fault earlier in the process. The cause of defects is very often “phase separation” (inhomogeneity in powder distribution, which can also be influenced by the holding pressure. This paper evaluates the powder distribution with a new method based on density measurement. Measurements were made using various holding pressure values.

  11. 'Holding' and 'endorsing' claims in the course of scientific activities.

    Science.gov (United States)

    Lacey, Hugh

    2015-10-01

    My principal aims are to show that holding, adopting and endorsing (definitions of which I provide) are distinct cognitive attitudes that may be taken towards claims at different moments of scientific activities, and that none of them are reducible to acceptance (as defined by Jonathan Cohen); to explore in detail the differences between holding and accepting, using the controversies about GMOs to provide illustrations; and to draw some implications pertinent to democratic decision-making concerning public policies about science and technology, and to the responsibilities that scientists thereby incur. PMID:26386534

  12. Adult Strabismus

    Science.gov (United States)

    ... will likely improve the double vision and depth perception. Also, strabismus affects adults in emotional, social, and ... muscle surgery is usually not severe. Headache, pulling sensation with eye movement and foreign body sensation in ...

  13. In vivo proton MRS of normal pancreas metabolites during breath-holding and free-breathing

    Energy Technology Data Exchange (ETDEWEB)

    Su, T.-H. [Department of Radiology, Beijing Friendship Hospital, Capital Medical University, 95 Yong-An Road, Beijing (China); Jin, E.-H., E-mail: erhujin1@hotmail.com [Department of Radiology, Beijing Friendship Hospital, Capital Medical University, 95 Yong-An Road, Beijing (China); Shen, H. [GE China Company Ltd, Healthcare, General Electric Company, Beijing (China); Zhang, Y.; He, W. [Department of Radiology, Beijing Friendship Hospital, Capital Medical University, 95 Yong-An Road, Beijing (China)

    2012-07-15

    Aim: To characterize normal pancreas metabolites using in vivo proton magnetic resonance spectroscopy ({sup 1}H MRS) at 3 T under conditions of breath-holding and free-breathing. Materials and methods: The pancreases of 32 healthy volunteers were examined using {sup 1}H MRS during breath-holding and free-breathing acquisitions in a single-voxel point-resolved selective spectroscopy sequence (PRESS) technique using a 3 T MRI system. Resonances were compared between paired spectra of the two breathing modes. Furthermore, correlations between lipid (Lip) content and age, body-mass index (BMI), as well as choline (Cho) peak visibility of the normal pancreas were analysed during breath-holding. Results: Twenty-nine pairs of spectra were successfully obtained showing three major resonances, Lip, Cho, cholesterol and the unsaturated parts of the olefinic region of fatty acids (Chol + Unsat). Breath-hold spectra were generally better, with higher signal-to-noise ratios (SNR; Z=-2.646, p = 0.008) and Cho peak visible status (Z=-2.449, p = 0.014). Correlations were significant between spectra acquired by the two breathing modes, especially for Lip height, Lip area, and the area of other peaks at 1.9-4.1 ppm. However, the Lip resonance was significantly different between the spectra of the two breathing modes (p < 0.05). In the breath-holding spectra, there were significant positive correlations between Lip peak height, area, and age (r = 0.491 and 0.521, p = 0.007 and 0.004), but not between Lip peak area and BMI. There was no statistical difference in Cho resonances between males and females. The Lip peak height and area were significantly higher in the Cho peak invisible group than in the Cho peak visible group (t = 2.661 and 2.353, p = 0.030 and 0.043). Conclusion: In vivo{sup 1}H MRS of the normal pancreas at 3 T is technically feasible and can characterize several metabolites. {sup 1}H MRS during breath-holding acquisition is superior to that during free

  14. Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment

    Directory of Open Access Journals (Sweden)

    Chan Godfrey CF

    2008-02-01

    Full Text Available Abstract Background Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated. Methods and Results The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this sequence, 5–10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34 and all were rescanned within one month at the standardization centre in London (intersite reproducibility. The local interstudy reproducibility (coefficient of variance and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms. Conclusion The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia.

  15. Physiological alterations in UV-irradiated cells: liquid holding recovery

    International Nuclear Information System (INIS)

    The biochemical and physiological alterations that occur in ultraviolet irradiated cells, during liquid holding have been studied. Incubation in buffer acts not to interfer directly with the mechanic repairs but by promoting metabolic alterations that would block some irreversible and lethal physiological responses. (L.M.J.)

  16. 26 CFR 1.543-1 - Personal holding company income.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Personal holding company income. 1.543-1 Section 1.543-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX.... Although the O Corporation particularly desired the services of A for an entertainment program it...

  17. Research Animal Holding Facility Prevents Space Lab Contamination

    Science.gov (United States)

    Savage, P. D., Jr.; Jahns, G. C.; Dalton, B. P.; Hogan, R. P.; Wray, A. E.

    1991-01-01

    Healthy environment for both rodents and human researchers maintained. Research animal holding facility (RAHF) and rodent cage prevent solid particles (feces, food bits, hair), micro-organisms, ammonia, and odors from escaping into outside environment during spaceflight. Rodent cage contains compartments for two animals. Provides each drinking-water dispenser, feeding alcove, and activity-monitoring port. Feeding and waste trays removable.

  18. Let's Hold Hands: A Project Connecting Children around the World

    Science.gov (United States)

    MacMillan, Meredith

    2010-01-01

    The story of the Let's Hold Hands dolls began in Korphe, a village in northern Pakistan. In 1933, after a failed attempt to climb K2, a weak, exhausted American mountaineer named Greg Mortenson staggered into Korphe. The villagers cared for him and helped him regain his strength. To repay their kindness, he vowed to return to help build the…

  19. The myth of the early aviation patent hold-up

    DEFF Research Database (Denmark)

    Katznelson, Ron D; Howells, John

    2015-01-01

    The prevailing historical accounts of the formation of the U.S. aircraft “patent pool” in 1917 assume the U.S. Government necessarily intervened to alleviate a patent hold-up among private aircraft manufacturers. We show these accounts to be inconsistent with the historical facts. We show that de...

  20. 49 CFR 176.145 - Segregation in single hold vessels.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Segregation in single hold vessels. 176.145 Section 176.145 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS... VESSEL Detailed Requirements for Class 1 (Explosive) Materials Segregation § 176.145 Segregation...

  1. Texas Hold 'em Online Poker: A Further Examination

    Science.gov (United States)

    Hopley, Anthony A. B.; Dempsey, Kevin; Nicki, Richard

    2012-01-01

    Playing Texas Hold 'em Online Poker (THOP) is on the rise. However, there is relatively little research examining factors that contribute to problem gambling in poker players. The aim of this study was to extend the research findings of Hopley and Nicki (2010). The negative mood states of depression, anxiety and stress were found to be linked to…

  2. A Hold-out method to correct PCA variance inflation

    DEFF Research Database (Denmark)

    Garcia-Moreno, Pablo; Artes-Rodriguez, Antonio; Hansen, Lars Kai

    2012-01-01

    introduced. We propose a Hold-out procedure whose computational cost is lower and, unlike the LOO method, the number of SVD's does not scale with the sample size. We analyze its properties from a theoretical and empirical point of view. Finally we apply it to a real classification scenario....

  3. 77 FR 32881 - Supervised Securities Holding Company Registration

    Science.gov (United States)

    2012-06-04

    ... the Board. C. Use of Plain Language Section 722 of the Gramm-Leach-Bliley Act requires the Federal banking agencies to use plain language in all proposed and final rules published after January 1, 2000... for a Foreign Organization to Acquire a U.S. Bank or Bank Holding Company (FR Y-3F; OMB No....

  4. Gas hold-up in stirred tank reactors

    NARCIS (Netherlands)

    Yawalkar, A.A.; Pangarkar, V.G.; Beenackers, A.A C M

    2002-01-01

    Based on a study of the gas hold-up data for stirred tank reactor generated in the present work and the data available in the literature for large stirred tank reactors (T = 0.57 m to 2.7 m) equipped with disc turbines and pitched blade downflow turbines a correlation is presented which reliably pre

  5. A sample-hold and analog multiplexer for multidetector systems

    International Nuclear Information System (INIS)

    A new sample-hold circuit with an analog multiplexer system is described. Designed for multichannel acquistion of data from an air shower array, the system is being used for accurate measurements of pulse heights from 16 channels by the use of a single ADC. (orig.)

  6. The physiology and pathophysiology of human breath-hold diving.

    Science.gov (United States)

    Lindholm, Peter; Lundgren, Claes E G

    2009-01-01

    This is a brief overview of physiological reactions, limitations, and pathophysiological mechanisms associated with human breath-hold diving. Breath-hold duration and ability to withstand compression at depth are the two main challenges that have been overcome to an amazing degree as evidenced by the current world records in breath-hold duration at 10:12 min and depth of 214 m. The quest for even further performance enhancements continues among competitive breath-hold divers, even if absolute physiological limits are being approached as indicated by findings of pulmonary edema and alveolar hemorrhage postdive. However, a remarkable, and so far poorly understood, variation in individual disposition for such problems exists. Mortality connected with breath-hold diving is primarily concentrated to less well-trained recreational divers and competitive spearfishermen who fall victim to hypoxia. Particularly vulnerable are probably also individuals with preexisting cardiac problems and possibly, essentially healthy divers who may have suffered severe alternobaric vertigo as a complication to inadequate pressure equilibration of the middle ears. The specific topics discussed include the diving response and its expression by the cardiovascular system, which exhibits hypertension, bradycardia, oxygen conservation, arrhythmias, and contraction of the spleen. The respiratory system is challenged by compression of the lungs with barotrauma of descent, intrapulmonary hemorrhage, edema, and the effects of glossopharyngeal insufflation and exsufflation. Various mechanisms associated with hypoxia and loss of consciousness are discussed, including hyperventilation, ascent blackout, fasting, and excessive postexercise O(2) consumption. The potential for high nitrogen pressure in the lungs to cause decompression sickness and N(2) narcosis is also illuminated. PMID:18974367

  7. Reliability of the Non-Communicating Adult Pain Checklist (NCAPC), Assessed by Different Groups of Health Workers

    Science.gov (United States)

    Lotan, M.; Moe-Nilssen, R.; Ljunggren, A. E.; Strand, L. I.

    2009-01-01

    Evaluating pain in adults with intellectual and developmental disability (IDD) is a challenge. The Non-Communicating Adults Pain Checklist (NCAPC) was recently developed from the Non-Communicating Children's Pain Checklist (NCCPC) and examined in a group of adults with IDD (N = 228) and found to hold satisfactory construct validity, internal…

  8. The hold-time effects on the low cycle fatigue behaviors of 316 SS in PWR primary environment

    International Nuclear Information System (INIS)

    The effects of the environments on fatigue life of the structural materials used in nuclear power plants (NPPs) were known to be significant according to the extensive test results. Accordingly, the fatigue analysis procedures and the design fatigue curves were proposed in the ASME Code. However, the implication that the existing ASME design fatigue curves did not sufficiently reflect the effect of the operation conditions of nuclear power plants emerged as an issue to be resolved. One of possible reasons to explain the discrepancy is that the laboratory test conditions do not represent the actual plant transients. Therefore, it is necessary to clarify the effects of light water environments on fatigue life while considering more plant-relevant transient conditions such as hold-time. For this reason, this study will focus on the fatigue life of type 316 stainless steel (SS) in the pressurized water reactor (PWR) environments while incorporating the hold-time during the low cycle fatigue (LCF) test in simulated PWR environments. The objective of this study is to characterize the effects of hold-time on the fatigue life of austenitic stainless steels in PWR environments in comparison with the existing fixed strain rate results. Low cycle fatigue life tests were conducted for the type 316 SS in 310 .deg. C air and simulated PWR environments. To simulate the heat-up and cool-down transient, sub-peak strain holding during the down-hill of strain amplitude was chosen. Currently, LCF tests with 60 seconds holding are in progress. The 0.4, 0.04%/s strain rate condition test results are presented in this study, which shows somewhat longer fatigue life

  9. On the relation between water pools and water holding capacity in cod muscle

    DEFF Research Database (Denmark)

    Andersen, Charlotte Møller; Jørgensen, Bo

    2004-01-01

    Low-field 1H nuclear magnetic resonance (NMR) relaxations were measured on muscle, minced muscle and centrifuged mince from cod that had been treated under various frozen and chill storage conditions. By using multi-way chemometrics, uni-exponential profiles were obtained, from which the transverse...... measures of water holding capacity (WHC) in a way that WHC related to the original water content could be predicted well for the whole and the minced muscle. The centrifuged samples gave optimal predictions of WHC related to the dry matter content, probably because the centrifuged samples are similar to...

  10. 26 CFR 1.553-1 - Foreign personal holding company income.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Foreign personal holding company income. 1.553-1... TAX (CONTINUED) INCOME TAXES (CONTINUED) Foreign Personal Holding Companies § 1.553-1 Foreign personal holding company income. Foreign personal holding company income shall consist of the items defined...

  11. 26 CFR 301.6501(f)-1 - Personal holding company tax.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Personal holding company tax. 301.6501(f)-1... Collection § 301.6501(f)-1 Personal holding company tax. If a corporation which is a personal holding company... capital stock of the corporation, the personal holding company tax for such year may be assessed, or...

  12. A comparison of the physiological responses to underwater arm cranking and breath holding between synchronized swimmers and breath holding untrained women.

    Science.gov (United States)

    Alentejano, Teresa C; Bell, Gordon J; Marshall, Dru

    2012-05-01

    Exercise and breath holding in the water such as that performed in the sport of synchronized swimming may evoke the physiological consequences of the diving response. The purpose of this study was to investigate the physiological responses of breath holding during underwater arm cranking in synchronized swimmers who are trained in breath holding and compare these responses to untrained women. Each participant performed 6 breath holding periods in the water (2 × 10s, 2 × 20s and 2 × 25s) with 2 minutes of normal breathing in between, in either an ascending or descending order while performing arm crank exercise. The intensity of arm crank exercise was set below the individual ventilatory threshold. Both synchronized swimmers and controls were matched on sitting height and then randomly divided into 2 groups: one group started breath holding with the longest (25s) breath holding periods while the other group began breath holding with the shortest (10s) breath holding periods. The synchronized swimmers experienced a significant decrease in heart rate while breath holding for 20 and 25s but the changes in heart rate for the control group was not consistent between subgroups. Full recovery from breath holding was identified for minute ventilation after 25s of recovery from breath holding for all groups. Results suggest synchronized swimmers exhibited a better adaptation to breath holding while exercising underwater. PMID:23487567

  13. Pharmacological blockade of either, cannabinoid CB1 or CB2 receptors, prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rats.

    Directory of Open Access Journals (Sweden)

    EDUARDO eBLANCO-CALVO

    2014-01-01

    Full Text Available Addiction to major drugs of abuse such as cocaine has been recently linked to alterations on adult neurogenesis in the hippocampus. The endogenous cannabinoid system modulated this proliferative response since pharmacological activation/blockade of cannabinoid CB1 and CB2 receptors by modulating not only neurogenesis but also cell death in the brain. In the present study, we evaluated whether the endogenous cannabinoid system affects cocaine-induced alterations in cell proliferation . To this end we examined if pharmacological blockade of either CB1 (Rimonabant, 3 mg/kg or CB2 receptors (AM630, 3 mg/kg affects cell proliferation (labeled with BrdU, found in the subventricular zone (SVZ of the lateral ventricles and the dentate subgranular zone (SGZ. In addition, we measured cell apoptosis (monitored by the expression of cleaved caspase-3 and glial activation ( by analizing the expression of GFAP and Iba-1 in the striatum and hippocampus, during acute or repeated (4 days cocaine administration (20 mg/kg. Results showed that acute cocaine decreased the number of BrdU+ cells in SVZ and SGZ. In contrast, repeated cocaine reduced the number of BrdU+ cells in SVZ only. Both acute and repeated cocaine increased the number of cleaved caspase-3+, GFAP+ and Iba1+ cells in the hippocampus, an effect counteracted by AM630 or Rimonabant that increased the number of BrdU+, GFAP+ and Iba1+ cells in the hippocampus. These results indicate that changes on neurogenic, apoptotic and gliosis processes, which were produced as a consequence of repeated cocaine administration, were normalized by the pharmacological blockade of CB1 and CB2. The restoring effects of cannabinoid receptor blockade on hippocampal cell proliferation were associated with a prevention of the induction of conditioned locomotion, but not of cocaine-induced sensitization.

  14. Weakened Immune System and Adult Vaccination

    Science.gov (United States)

    ... click "GO" or visit Healthmap Vaccine Finder . Weakened Immune System and Adult Vaccination Recommend on Facebook Tweet Share ... people with health conditions such as a weakened immune system. If you have cancer or other immunocompromising conditions, ...

  15. The carbon holdings of northern Ecuador's mangrove forests

    CERN Document Server

    Hamilton, Stuart E; Borbor, Mercy; Millones, Marco

    2016-01-01

    Within a GIS environment, we combine field measures of mangrove diameter, mangrove species distribution, and mangrove density with remotely sensed measures of mangrove location and mangrove canopy cover to estimate the mangrove carbon holdings of northern Ecuador. We find that the four northern estuaries of Ecuador contain approximately 7,742,999 t (plus or minus 15.47 percent) of standing carbon. Of particular high carbon holdings are the Rhizophora mangle dominated mangrove stands found in-and-around the Cayapas-Mataje Ecological Reserve in northern Esmeraldas Province, Ecuador and certain stands of Rhizophora mangle in-and-around the Isla Corazon y Fragata Wildlife Refuge in central Manabi Province, Ecuador. Our field driven mangrove carbon estimate is higher than all but one of the comparison models evaluated. We find that basic latitudinal mangrove carbon models performed at least as well, if not better, than the more complex species based allometric models in predicting standing carbon levels. In additi...

  16. Emulsifying salt increase stability of cheese emulsions during holding

    DEFF Research Database (Denmark)

    Hougaard, Anni Bygvrå; Sijbrandij, Anna G.; Varming, Camilla;

    2015-01-01

    In cheese powder production, cheese is mixed and melted with water and emulsifying salt to form an emulsion (cheese feed) which is required to remain stable at 60°C for 1h and during further processing until spray drying. Addition of emulsifying salts ensures this, but recent demands for reduction...... of sodium and phosphate in foods makes production of cheese powder without or with minimal amounts of emulsifying salts desirable. The present work uses a centrifugation method to characterize stability of model cheese feeds. Stability of cheese feed with emulsifying salt increased with holding time at 60°C......, especially when no stirring was applied. No change in stability during holding was observed in cheese feeds without emulsifying salt. This effect is suggested to be due to continued exerted functionality of the emulsifying salt, possibly through reorganizations of the mineral balance....

  17. CPR: Adult

    Medline Plus

    Full Text Available Refresher Center Home FIRST AID, CPR and AED LIFEGUARDING Refresher Putting It All Together: CPR—Adult (2:03) Refresher videos only utilize this player QUICK LINKS Home RedCross.org Purchase Course Materials Shop Our Store ...

  18. Does Competition Solve the Hold-up Problem?

    OpenAIRE

    Leonardo Felli; Kevin Roberts

    2001-01-01

    In an environment in which both buyers and sellers can undertake match specific investments, the presence of market competition for matches may solve hold-up and coordination problems generated by the absence of complete contingent contracts. In particular, this paper shows that when matching is assortative and sellers' investments precede market competition then investments are constrained efficient. One equilibrium is efficient with efficient matches but also there can be equilibria with co...

  19. Does competition solve the hold-up problem?

    OpenAIRE

    Leonardo Felli; Kevin Roberts

    2001-01-01

    In an environment in which both buyers and sellers can undertake match specific investments, the presence of market competition for matches may solve hold-up and coordination problems generated by the absence of complete contingent contracts. In particular, this paper shows that when matching is assortative and sellers’ investments precede market competition then investments are constrained efficient. One equilibrium is efficient with efficient matches but also there can be equilibria with co...

  20. Does Competition Solve the Hold-up Problem?

    OpenAIRE

    Leonardo Felli; Kevin Roberts

    2000-01-01

    In an environment in which both workers and firms undertake match specific investments, the presence of market competition for matches may solve the hold-up problems generated by the absence of complete contingent contracts. In particular, this paper shows that when matching is assortative and workers' investments precede market competition for matches investments are constrained efficient. Inefficiencies can arise in this framework as multiple equilibria of the competition game. Only one of ...

  1. Does Competition Solve the Hold-up Problem?

    OpenAIRE

    Kevin Roberts; Leonardo Felli

    2000-01-01

    In an environment in which both buyers and sellers can undertake match specific investments, the presence of market competition for matches may solve hold-up and coordination problems generated by the absence of complete contingent contracts. In particular, this paper shows that when matching is assortative and sellers investments precede market competition then investments are constrained efficient. One equilibrium is efficient with efficient matches but also there can be equilibria with coo...

  2. What determines the use of holding companies and ownership chains?

    OpenAIRE

    Alfons J. Weichenrieder; Jack Mintz

    2008-01-01

    The paper investigates the role of holding companies and conduit entities in German inbound and outbound FDI. It identifies the relevant conduit countries that act as stepping stones. Several tax and non-tax factors for the set-up of indirect structures are empirically identified. Withholding taxes, credit systems in capital exporting countries and the possibility of group consolidation are shown to be empirically important for the design of ownership chains in foreign direct investment.

  3. 举办晚会%Holding a Party

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ Please be quiet,everyone.I have something important to tell you.The Students Union is going to hold a party on Saturday evening,August 15,to welcome our friend from England.The party will be held in the third floor of the Main Building.It will begin at 7:50 p.m.There is music,singing,dancing games and exchanging of gifts.

  4. Clinical and Laboratory Findings of Patients with Breath Holding Spells

    Directory of Open Access Journals (Sweden)

    Özlem Özdemir

    2009-09-01

    Full Text Available Aim: The aim of this prospective study was to evaluate the clinical characteristics; physical findings, cardiological, hematological and neurological problems; treatment approaches; and the prognosis of children with breath holding spells.Materials and Method: Seventhy patients were included in this study. All patients were evaluated with detailed history and physical examination. Complete blood count, serum iron and iron binding capacity were studied; cardiological (telecardiography, electrocardiography, if necessary echocardiography and event recorder and neurological investigations (electroencephalography were done during the admission. Patients with iron deficiency anemia and iron deficiency were treated with ferrous sulphate orally. In patients with normal hematological values, no medication was used. After a two-month treatment period patients underwent control hematological evaluation. Frequency of the spells, age of disappearance of spells (defined as 6 months without spells, disappearance ratios between the three groups were compared. Results: The percentage of cyanotic, palloric and mixt type of breath holding spells of 70 patients included in the study were 67.1, 14.3 and 18.6, respectively. It was determined that psychogenic factors played a role in 77.1% of our patients. There were iron deficiency anemia in 39 (55.7%, iron deficiency in 12 (17.2% and normal hematological parameters in 19 (27.1% of 70 patients. The QTc values were normal in all of them. EEG’s were normal in 56 (80%, dysrhythmic in 11 (15.7% and pathologic in (4.3%. There was a positive family history of breath holding spells in 44.3% of those with breath holding spells. Conclusion: We determined that there was a correlation between the iron levels and the frequency of spells. The lower the iron levels the higher the frequency of spells. There was a dramatic decrease of 92% in spells with low doses of iron supplementation especially in the anemic group. (Journal of

  5. A superconducting analog track-and-hold circuit

    International Nuclear Information System (INIS)

    A superconducting analog track-and-hold circuit has been designed, fabricated, and tested. Experimental results demonstrate a 1.2-GHz bandwidth and a 25-dB dynamic range. Model calculations indicate that an optimized circuit with a critical current density of 10,000 A/cm/sup 2/ can achieve a 4-GHz bandwidth and a 35-dB dynamic range

  6. Please Hold me Up: Why Firms Grant Exclusive Dealing Contracts

    OpenAIRE

    David De Meza; Marianno Selvaggi

    2003-01-01

    Why do irreplaceable firms with a choice of suppliers or customers deliberately expose themselves to the threat of hold up by contracting ex ante to deal with only one of them? Our explanation revolves around the multiple equilibria intrinsic to situations of unverifiable investment and many traders. Exclusive dealing eliminates inefficient equilibria in which too many firms invest too little. The enhanced ex post bargaining power of the chosen firm is beneficial for incentives whilst the dis...

  7. Cortical mechanisms for shifting and holding visuospatial attention

    OpenAIRE

    Kelley, Todd A.; Serences, John T.; Giesbrecht, Barry; Yantis, Steven

    2007-01-01

    Access to visual awareness is often determined by covert, voluntary deployments of visual attention. Voluntary orienting without eye movements requires decoupling attention from the locus of fixation, a shift to the desired location and maintenance of attention at that location. We used event-related fMRI to dissociate these components while observers shifted attention among three streams of letters and digits, one located at fixation and two in the periphery. Compared to holding attention at...

  8. Clinical and Laboratory Findings of Patients with Breath Holding Spells

    OpenAIRE

    Özlem Özdemir; Serpil Çalışkan Can; Evren Semizel; Mehmet S. Okan

    2009-01-01

    Aim: The aim of this prospective study was to evaluate the clinical characteristics; physical findings, cardiological, hematological and neurological problems; treatment approaches; and the prognosis of children with breath holding spells.Materials and Method: Seventhy patients were included in this study. All patients were evaluated with detailed history and physical examination. Complete blood count, serum iron and iron binding capacity were studied; cardiological (telecardiography, electro...

  9. Holding Period Return-Risk Modeling: Ambiguity in Estimation

    OpenAIRE

    2003-01-01

    In this paper we explore the theoretical and empirical problems of estimating average (excess) return and risk of US equities over various holding periods and sample periods. Our findings are relevant for performance evaluation, for estimating the historical equity risk premium, and for investment simulation. Using a unique set of US equity data series, comprising monthly prices and dividends based on consistent definitions over the 132 year period 1871-2002, we investigate the complex effect...

  10. Holding Period Return-Risk Modeling: Ambiguity in Estimation

    OpenAIRE

    Hallerbach, Winfried

    2003-01-01

    textabstractIn this paper we explore the theoretical and empirical problems of estimating average (excess) return and risk of US equities over various holding periods and sample periods. Our findings are relevant for performance evaluation, for estimating the historical equity risk premium, and for investment simulation. Using a unique set of US equity data series, comprising monthly prices and dividends based on consistent definitions over the 132 year period 1871-2002, we investigate the co...

  11. Roles and challenges of Brazilian small holding agriculture

    OpenAIRE

    Buainain, Antonio Marcio; Garcia, Junior Ruiz

    2013-01-01

    This paper aims at a critical review of roles, perspectives and challenges of small holding agriculture in Brazil, highlighting in particular the role of public policies and technological innovation in meeting current challenges to secure poverty reduction and sustainable growth. Though the paper draws exclusively from the Brazilian experience, some of the issues raised reflect also the reality of other Latin American countries. Lessons and policy implications for other emerging economies wil...

  12. Legal Statement authorized by Veken Holding Group Co.,Ltd.

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    According to Patent Law of the People’s Republic of China,Implementing Regulations of the Patent Law of the People’s Republic of China,and other laws and regulations,Zhejiang Heyi Law Office has been authorized by Veken Holding Group Co.,Ltd.("Veken Group")to announce the statement as below to protect the legal rights of the patentee.

  13. Lodging of a constitutional complaint. Reason: Inhibition to hold a demonstration

    International Nuclear Information System (INIS)

    The Federal Consitutional Court states the conditions allowing issue of a preliminary order of court - in this case, for reinstating the suspensive effect of a protest lodged against an inhibition to hold a demonstration, i.e. for allowing the demonstration to be held - in the event that due to lack of time the Federal Constitutional Court is not in a position to sufficiently clarify the state of facts. The constitutional complaint and petition for preliminary order had been filed at the evening before the day the demonstration was planned to be held. Judging from the facts and circumstances given in the notice inhibiting the demonstration, and the conditions stated by the Administrative Court, there is reason enough to presume that holding the demonstration near the building site of the Wackersdorf Reprocessing Plant will very likely lead to endangering public peace and order. Against this background, the Federal Constitutional Court cannot see reasons to deviate from the assessment of facts given in the decision protested against. This all the more as the wording of the attacked decisions is such that it can be assumed that the constitutional principles stated by the Federal Constitutional Court in its Brokdorf decision (of May 14, 1985) have duly been taken into account. (orig./HSCH)

  14. Exploring Clinical Psychology Doctoral Students' Attitudes towards Adults with Substance Use Disorders

    Science.gov (United States)

    Mundon, Chandra R.

    2013-01-01

    This study sought to determine whether clinical psychology doctoral students hold uniquely stigmatizing views of adults with substance use disorders (SUDs) compared to adults with other clinical disorders. Through the use of clinical vignettes and attitudinal measures, three hypotheses investigated clinical psychology doctoral students'…

  15. "An Elusive Bird": Perceptions of Music Learning among Canadian and American Adults

    Science.gov (United States)

    Kruse, Nathan B.

    2009-01-01

    Discovering the perceptions that non-professional adult musicians hold regarding their participation in community ensembles may help improve instruction as well as the ability to more fully understand the implications of lifelong music making. Andragogy, or the teaching and learning strategies associated with adult learning, provided the impetus…

  16. The Impact of Labels and Behaviors on the Stigmatization of Adults with Asperger's Disorder

    Science.gov (United States)

    Butler, Robert C.; Gillis, Jennifer M.

    2011-01-01

    Currently, there is a paucity of literature on stigmatization of adults with Asperger's Disorder (AD). Therefore, this study examined whether young adults hold stigmatizing views towards individuals with AD and if that stigmatization is elicited by behaviors or labels. College students (N = 195) read one of six vignettes. A modified Social…

  17. [Adult twins].

    Science.gov (United States)

    Charlemaine, Christiane

    2006-12-31

    This paper explores the deep roots of closeness that twins share in their youngest age and their effect on their destiny at the adult age. Psychologists believe the bond between twins begins in utero and develops throughout the twins' lives. The four patterns of twinship described show that the twin bond is determined by the quality of parenting that twins receive in their infancy and early childhood. Common problems of adult twins bring about difficulties to adapt in a non-twin world. The nature versus nurture controversy has taken on new life focusing on inter-twin differences and the importance of parent-child interaction as fundamental to the growth and development of personality. PMID:17352324

  18. Major Depression Among Adults

    Science.gov (United States)

    ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ...

  19. Panic Disorder among Adults

    Science.gov (United States)

    ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ...

  20. Bipolar Disorder Among Adults

    Science.gov (United States)

    ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ...

  1. Obstructive sleep apnea - adults

    Science.gov (United States)

    Sleep apnea - obstructive - adults; Apnea - obstructive sleep apnea syndrome - adults; Sleep-disordered breathing - adults; OSA - adults ... When you sleep, all of the muscles in your body become more relaxed. This includes the muscles that help keep your ...

  2. Adult Immunization

    OpenAIRE

    Omer Coskun

    2008-01-01

    Despite the many advances in modern medicine, each year thousands of people in the world die from diseases that are easily prevented by safe and effective vaccines. Few measures in preventive medicine are of such proven value and as easy to implement as routine immunization against infectious diseases. Prevention of infection by immunization is a lifelong process. There are a number of vaccines that all adults (¡I18 years) require. There are also other vaccines that need to be tailored t...

  3. Adult Leukemias

    OpenAIRE

    Moore, Lyall K.

    1984-01-01

    Over the past several years, advances have been made in the classification, diagnosis and therapy of the adult leukemias. The overall prognosis and quality of life have improved greatly, especially for patients with acute nonlymphoblastic leukemias. Some of the advances are described in this article. The importance of the clinical, laboratory and diagnostic tests for acute, chronic granulocytic and chronic lymphocytic leukemia are stressed. The therapy and prognosis for patients with the vari...

  4. A case of spinal epidural haematoma during breath-hold diving.

    Science.gov (United States)

    Tremolizzo, Lucio; Patassini, Mirko; Malpieri, Massimo; Ferrarese, Carlo; Appollonio, Ildebrando

    2012-06-01

    Spinal epidural haematoma (SEH) is a rare condition usually the result of bleeding of the epidural venous plexus that might present with acute spinal cord compression. It is often due to traumatic events, but 'spontaneous' cases have been described, usually related to different predisposing conditions, such as coagulopathies. A 47-year-old male presented with severe frontal headache and intense cervical pain which developed during a protracted breath-hold spearfishing session. A cervical spine MRI performed 12 days after symptom onset showed a small epidural blood collection on the left side of the spinal canal, at the C7-T1 level. One week later, blood was no longer present and the asymptomatic patient was discharged. Protracted minor trauma (neck flexion) and repeated Valsalva manoeuvres might have played a role in the genesis of this event. The role of decompression sickness is discussed as well. PMID:22828819

  5. Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat.

    Science.gov (United States)

    Blanco-Calvo, Eduardo; Rivera, Patricia; Arrabal, Sergio; Vargas, Antonio; Pavón, Francisco Javier; Serrano, Antonia; Castilla-Ortega, Estela; Galeano, Pablo; Rubio, Leticia; Suárez, Juan; Rodriguez de Fonseca, Fernando

    2014-01-01

    Addiction to major drugs of abuse, such as cocaine, has recently been linked to alterations in adult neurogenesis in the hippocampus. The endogenous cannabinoid system modulates this proliferative response as demonstrated by the finding that pharmacological activation/blockade of cannabinoid CB1 and CB2 receptors not only modulates neurogenesis but also modulates cell death in the brain. In the present study, we evaluated whether the endogenous cannabinoid system affects cocaine-induced alterations in cell proliferation. To this end, we examined whether pharmacological blockade of either CB1 (Rimonabant, 3 mg/kg) or CB2 receptors (AM630, 3 mg/kg) would affect cell proliferation [the cells were labeled with 5-bromo-2'-deoxyuridine (BrdU)] in the subventricular zone (SVZ) of the lateral ventricle and the dentate subgranular zone (SGZ). Additionally, we measured cell apoptosis (as monitored by the expression of cleaved caspase-3) and glial activation [by analyzing the expression of glial fibrillary acidic protein (GFAP) and Iba-1] in the striatum and hippocampus during acute and repeated (4 days) cocaine administration (20 mg/kg). The results showed that acute cocaine exposure decreased the number of BrdU-immunoreactive (ir) cells in the SVZ and SGZ. In contrast, repeated cocaine exposure reduced the number of BrdU-ir cells only in the SVZ. Both acute and repeated cocaine exposure increased the number of cleaved caspase-3-, GFAP- and Iba1-ir cells in the hippocampus, and this effect was counteracted by AM630 or Rimonabant, which increased the number of BrdU-, GFAP-, and Iba1-ir cells in the hippocampus. These results indicate that the changes in neurogenic, apoptotic and gliotic processes that were produced by repeated cocaine administration were normalized by pharmacological blockade of CB1 and CB2. The restorative effects of cannabinoid receptor blockade on hippocampal cell proliferation were associated with the prevention of the induction of conditioned locomotion

  6. Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat

    Science.gov (United States)

    Blanco-Calvo, Eduardo; Rivera, Patricia; Arrabal, Sergio; Vargas, Antonio; Pavón, Francisco Javier; Serrano, Antonia; Castilla-Ortega, Estela; Galeano, Pablo; Rubio, Leticia; Suárez, Juan; Rodriguez de Fonseca, Fernando

    2014-01-01

    Addiction to major drugs of abuse, such as cocaine, has recently been linked to alterations in adult neurogenesis in the hippocampus. The endogenous cannabinoid system modulates this proliferative response as demonstrated by the finding that pharmacological activation/blockade of cannabinoid CB1 and CB2 receptors not only modulates neurogenesis but also modulates cell death in the brain. In the present study, we evaluated whether the endogenous cannabinoid system affects cocaine-induced alterations in cell proliferation. To this end, we examined whether pharmacological blockade of either CB1 (Rimonabant, 3 mg/kg) or CB2 receptors (AM630, 3 mg/kg) would affect cell proliferation [the cells were labeled with 5-bromo-2′-deoxyuridine (BrdU)] in the subventricular zone (SVZ) of the lateral ventricle and the dentate subgranular zone (SGZ). Additionally, we measured cell apoptosis (as monitored by the expression of cleaved caspase-3) and glial activation [by analyzing the expression of glial fibrillary acidic protein (GFAP) and Iba-1] in the striatum and hippocampus during acute and repeated (4 days) cocaine administration (20 mg/kg). The results showed that acute cocaine exposure decreased the number of BrdU-immunoreactive (ir) cells in the SVZ and SGZ. In contrast, repeated cocaine exposure reduced the number of BrdU-ir cells only in the SVZ. Both acute and repeated cocaine exposure increased the number of cleaved caspase-3-, GFAP- and Iba1-ir cells in the hippocampus, and this effect was counteracted by AM630 or Rimonabant, which increased the number of BrdU-, GFAP-, and Iba1-ir cells in the hippocampus. These results indicate that the changes in neurogenic, apoptotic and gliotic processes that were produced by repeated cocaine administration were normalized by pharmacological blockade of CB1 and CB2. The restorative effects of cannabinoid receptor blockade on hippocampal cell proliferation were associated with the prevention of the induction of conditioned

  7. Effects of Saving and Spending Patterns on Holding Time Distribution

    CERN Document Server

    Ding, N; Wang, Y; Ding, Ning; Xi, Ning; Wang, Yougui

    2003-01-01

    The effects of saving and spending patterns on holding time distribution of money are investigated based on the ideal gas-like models. We show the steady-state distribution obeys an exponential law when the saving factor is set uniformly, and a power law when the saving factor is set diversely. The power distribution can also be obtained by proposing a new model where the preferential spending behavior is considered. The association of the distribution with the probability of money to be exchanged has also been discussed.

  8. Introduction to probability with Texas Hold'em examples

    CERN Document Server

    Schoenberg, Frederic Paik

    2011-01-01

    ""… quite entertaining and fun to read. … I had a very good time reading this book … as a teacher this is definitely a book I would recommend as a pleasant introduction to the world of probability theory.""-Julien Sohier, CHANCE, June 2013""The students will need to understand and have some familiarity with the rules and play of Texas Hold'em. Subject to that, this provides a refreshing new introduction to the subject matter. It is certainly worth considering for your next year's intake of students.""-David J. Hand, International Statistical Review (2013), 81, 2""Recent trends in probability a

  9. Henan Non-ferrous Holding Company Set Up in Henan

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>Henan Non-ferrous Holding Co.(hereinafter referred to as Henan Non-ferrous),an enterprise set up under the joint effort of 3 enterprises with state-owned assets namely Shenhuo Group,Yichuan Power and Yulian Group,has started its operation under tight schedule.The focus of the current operation is acquisition,for which a number of alumina and aluminum processing enterprises are on the list of Henan Non-ferrous.China Nonferrous Metals Monthly reported this news at our last issue,now we try to analysis more details behind the decision.

  10. A head-holding device for computed tomography

    International Nuclear Information System (INIS)

    Immobilization of the head using a bite plate and a head immobilizer was studied. Head was fixed by holding both ears by acryl plates with small metal rings inserted to ear holes. The position of the head was adjusted by the computed radiogram of the tings. A U-type ABS resin with molybdenum compound was developed as a bite plate. Reproducibility test of the computed tomogram showed that the error of the position and angle was within 1 mm 10, respectively. (Nakanishi, T.)

  11. Public Utility Holding Company Act of 1935: 1935--1992

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-15

    This report provides an economic and legislative history and analysis of the Public Utilities Holding Company Act (PUHCA) of 1935. This Act was substantially amended for the first time in 1992 by passage of the Energy Policy Act (EPACT). The report also includes a discussion of the issues which led to the amendment of PUHCA and projections of the impact of these changes on the electric industry. The report should be of use to Federal and State regulators, trade associations, electric utilities, independent power producers, as well as decision-makers in Congress and the Administration.

  12. La Holding Estrategia Fiscal Para las Empresas Familiares

    OpenAIRE

    Rosa Hilda Hernandez Sandoval; Sandra Patricia de la Garza Cienfuegos; Laura Leticia Gaona Tamez

    2010-01-01

    La presente investigación se realizó en Monclova, Coah., en el año 2011 y tiene por objeto constituir una empresa holding para obtener beneficios fiscales sin caer en la evasión o elusión fiscal, esta alternativa permite controlar desde la cúspide a las demás empresas subsidiarias que han sido creadas. Los resultados muestran que existen en México 4,862 empresas familiares que consolidan para efectos fiscales, las cuales se encuentran integradas en 422 grupos. En este régimen de fiscalización...

  13. 青壮年肺结核发病影响因素的条件Logistic回归分析%A Conditional Logistic Regression Analysis on Risk Factors of Pulmonary Tuherculosis in Young Adults

    Institute of Scientific and Technical Information of China (English)

    唐惠红; 何志青; 龚芳; 胡贵方; 资青兰

    2012-01-01

    目的 探讨25~54岁青壮年肺结核发病的影响因素.方法 抽取广州市25~54岁青壮年涂阳肺结核患者150例,从涂阳肺结核患者家庭密切接触者中按照与病例性别相同、年龄相近(≤3岁)原则作1∶1配对,使用统一的调查表进行调查;对24个变量进行单因素条件Logistic回归分析,筛选出有统计学意义的变量再采用多因素条件Logistic回归分析.结果 单因素分析发现14个变量与青壮年肺结核发生有关;其中低收入、承担家庭经济主要责任、吸烟、饮酒、婚姻、住房拥挤、居室阴暗、生活事件总刺激量和消极应对9个变量经多因素分析进入模型,OR(95.0%CI)分别为6.444(2.467~16.834)、3.083(1.026~9.260)、1.383(0.961~1.988)、2.161(1.231~3.794)、0.038(0.008~0.177)、28.505(1.263~643.123)、4.792(1.793~ 12.808)、1.031(1.006~1.057)、1.087(1.000~1.181).结论 低收入、承担家庭经济主要责任、吸烟、饮酒、住房拥挤、居室阴暗、生活事件总刺激量大和消极应对是青壮年肺结核的危险因素,婚姻是青壮年肺结核的保护因素.%Objective To explore the risk factors of pulmonary tuberculosis (TB) among young adults of 25 - 54 years of age. Methods A total of 150 new smear - positive pulmonary TB patients aged 25 - 54 years in Guangzhou were recruited as cases. The same amount of healthy people from family members with close contact with the patients was recruited as controls and paired with the cases according to the same gender and similar age (age gap, no more than 3 years). Interview was carried out with a uniform questionnaire. Variables of statistical significance screened from 24 variables by the univariate conditional Logistic regression analysis were further subjected to multivariate conditional Logistic regression analysis. Results The univariate analysis showed that 14 variables were associated with TB prevalence, among which 9 variables, that is, low income

  14. Corporate Cash Holdings and Shareholder Risk : Investigating the relationship between corporate cash holdings and the risk of stocks listed on the Stockholm Stock Exchange

    OpenAIRE

    Olausson, Jonas; Löfgren, Christoffer

    2013-01-01

    Corporate cash holdings is a topic constantly under review, companies hoarding cash are criticized by shareholders who rather have companies using their cash for new investments or dividend payouts. Recent academic research has discovered that levels of cash holding are high in times when risk is deemed to be high and found that levels of corporate cash holdings are substantially higher than they used to, making more coverage and a better understanding of the phenomenon crucial. This thesis i...

  15. Adult hepatoblastoma

    OpenAIRE

    Javier A. Cienfuegos; Tania Labiano; Nicolás Pedano; Gabriel N. Zozaya; Pablo Martí-Cruchaga; Ángel Panizo; Fernando Rotellar

    2013-01-01

    Adult hepatoblastoma (AHB) is a very rare tumor, having been described 45 cases up to June 2012. In contrast to HB in infancy (IHB), it has poor prognosis. We present the case of a 37-year-old asymptomatic woman who consulted for a large -12 cm diameter- mass involving segments 5 and 6 of the liver, and alfa-fetoprotein of 1,556,30 UI/mL. A bisegmentectomy was carried out. The microscopic study confirmed the AHB diagnosis, revealing the presence of epithelial cells forming clusters, trabecula...

  16. In which Financial Markets do Mutual Fund Theorems hold true?

    CERN Document Server

    Schachermayer, Walter; Taflin, Erik

    2007-01-01

    The Mutual Fund Theorem (MFT) is considered in a general semimartingale financial market S with a finite time horizon T, where agents maximize expected utility of terminal wealth. It is established that: 1) Let N be the wealth process of the num\\'eraire portfolio (i.e. the optimal portfolio for the log utility). If any path-independent option with maturity T written on the num\\'eraire portfolio can be replicated by trading \\emph{only} in N, then the (MFT) holds true for general utility functions, and the num\\'eraire portfolio may serve as mutual fund. This generalizes Merton's classical result on Black-Scholes markets. Conversely, under a supplementary weak completeness assumption, we show that the validity of the (MFT) for general utility functions implies the same replicability property for options on the num\\'eraire portfolio described above. 2) If for a given class of utility functions (i.e. investors) the (MFT) holds true in all complete Brownian financial markets S, then all investors use the same utili...

  17. BREATH-HOLDING SPELLS: AN ANALYSIS OF 43 CASES

    Directory of Open Access Journals (Sweden)

    M.R. Ashrafi

    2006-10-01

    Full Text Available Objective:Breath holding spells, very often misinterpreted as epileptic seizures,are most common in children aged 6 months to 6 years of age. Inthis investigation, we sought to prospectively document the naturalhistory of breath holding spells (BHS among children with cyanotic,pallid and mixed type BHS referred for neurological consultation.Materials & Methods:This was a cross-sectional study in which a total of 43 children (23boys, 20 girls with BHS, admitted to the out patient clinic of theChildren's Hospital Medical Center, between Sept 1998 and June1999, were enrolled. A structured interview was under taken at thetime of initial consultation to confirm BHS and its type, associatedphenomenon, family history, sex and age at initiation of spells.Laboratory, electroencephalographic and electrocardiographic testswere done.Results:Patients were between 1.7 and 42.8 months (mean age 18.4 months.In 76.8% of cases, BHS began during the first 12 months of age.Anger and pain were the most common triggering factors (65.1 %.A positive family history of BHS was identified in 51% and parentalconsanguinity was found in 30% of cases. The spells were cyanoticin 79.1% (34 children. 78% of cases were iron deficient and 53%of cases had iron deficiency anemia.Conclusion:The results of this study emphasize the role of genetic factors in BHS;measurement of hemoglobin and serum ferritin is recommended allsuch cases

  18. In vitro holding and PLD repair. Pt. 1

    International Nuclear Information System (INIS)

    The stationary or plateau-phase of commonly used rodent cell lines like the V79 are often assumed to be quiescent (non-mitotic). An analysis of cell turnover in V79 plateau-phase cultures through BrUdR-incorporation combined with FUdR-block and light exposure (S-phase cytocide) revealed such cultures to be in a state of kinetic equilibrium. Even when the state of maximal permissible density was acquired, at least 50% of the population of cells were cycling within the time for one population doubling. Attempts at holding the cells from cycling (through nutrient-depletion and serum-privation) were unsuccessful, although the turnover-rate was reduced. Our assays for X-irradiated clonogenic survivors after attempted holding combined with delayed plating (DP) showed differences in the survival curves for exponentially growing and confluent cultures. Elimination of cycling cells by S-phase cytocide removed these differences. Since a significant fraction of plateau-phase cells are not mitotically quiescent (Q), one must eliminate the proliferating (P) fraction if one wishes to examine the PLDR of the Q cells. For V79 cells, removal of the P cells eliminates the higher survival (usually interpreted as Q cell PLDR) of plateau-phase cells. (orig.)

  19. Holdings of type specimens of plants in herbaria of China

    Directory of Open Access Journals (Sweden)

    Yong Yang

    2012-07-01

    Full Text Available Species diversity is one of the central topics of biodiversity. Type specimens are the permanent vouchers of taxonomic names, and are irreplaceable as a means to safeguard the stability of the nomenclatural system. Holdings of common specimens and type specimens are indices reflecting historical accumulation of botanical studies for a certain country or region. This paper reviews holdings of common specimens and type specimens in herbaria worldwide and those native to China. Overall, we conclude that type collections in herbaria of China are relatively less than the world on average, because plants from China were studied by western botanists for over 400 years before Chinese botanists started to collect specimens and study plants in the early twentieth century. Based on digitization of type specimens housed in native herbaria, it is now urgent to digitize not only type specimens of Chinese herbaria, but also those held in herbaria abroad. In addition, the number of collections per species in Chinese herbaria is much less than the world average. For Chinese botanical researchers, it is important to conduct investigations in poorly studied areas in China and overseas, and to enhance the overall number and representation of specimens for each species.

  20. Clinical Efficacy of Piracetam on Breath Holding Spells in Children

    Directory of Open Access Journals (Sweden)

    F. Ashrafzadeh

    2004-07-01

    Full Text Available Breath holding spells (BHS is a type of syncope in children , most commonly encontered in the early years of life. Although these athacks don't damage the brain , if these are frequent or prolonged cause , parents frighten , so physician should intervent. In this study we evaluated clinical efficacy of piracetam on B.H.S of children in Mashhad Ghaem Hospital during 2001-2002.In this double blind placebo control study , piracetam or placebo on a randomized basis was administered to children with 40 mg/kg/day in 2 divided doses for 2 months. From the 41 children that were enrolled , 21 cases received piracetam and 20 cases received placebo. Parents denoted the numbers of spells two months before and two months after taking drug. Control of breath holding spells were observed in 90.5% of patients in the group taking piracetam as compared with 40% in the group taking placebo (P = 0.002. Of the all patients 10 cases had iron deficiency anemia so they had taken elemental Fe too. The side effects were the same in these two groups. The results of this study indicated that piracetam was efficient for the treatment of children with B.H.S without greater incidence adverse effects than placebo.

  1. Obtaining a TRIP microstructure by thermomechanical treatment without isothermal holding

    Science.gov (United States)

    Masek, B.; Jirkova, H.; Kucerova, L.; F-X Wagner, M.

    2016-03-01

    The contemporary development of technological processes for the production of modern multiphase steels can be characterized by the need for precise control of their technological parameters. The design of modern technological processes that allow sophisticated microstructures to be obtained usually cannot be carried out on real production equipment for technical as well as economical reasons. Therefore, new processes and test devices are continuously being developed to make it possible to simulate and model thermomechanical treatments on small specimens with precise control and monitoring of process parameters. A simulator for experimental modelling of thermomechanical processes has been developed at the University of West Bohemia. In this paper, to demonstrate the feasibility of simulating thermomechanical treatments with this setup on a lab scale, we discuss the thermomechanical treatment of TRIP steels without isothermal holding - a processing route that is difficult to handle and thus poses several technological as well as economic problems. The realistic processing of wire rolling with different cooling strategies is tested on the TRIP CMnSiNb steel. Our results show that the processing route without isothermal holding allows to obtain multiphase microstructures with a tensile strength of up to 835 MPa and a ductility A5mm = 25%.

  2. A Comparison of the Physiological Responses to Underwater Arm Cranking and Breath Holding Between Synchronized Swimmers and Breath Holding Untrained Women

    OpenAIRE

    Alentejano, Teresa C.; Bell, Gordon J; Marshall, Dru

    2012-01-01

    Exercise and breath holding in the water such as that performed in the sport of synchronized swimming may evoke the physiological consequences of the diving response. The purpose of this study was to investigate the physiological responses of breath holding during underwater arm cranking in synchronized swimmers who are trained in breath holding and compare these responses to untrained women. Each participant performed 6 breath holding periods in the water (2 × 10s, 2 × 20s and 2 × 25s) with ...

  3. Refractories materials characterization for aluminum melting and holding furnaces: an alternative for a better performance

    International Nuclear Information System (INIS)

    The industrial needs in reducing the energy consumption is part of a continuing search towards higher levels of sustainability and competitiveness. Considering these aspects, the aluminum industry seeks new alternatives for a better performance of aluminum melting and holding furnaces and this aim is directly dependent on the refractory materials ability to conserve heat and withstand the mechanical, chemical and thermal degradation processes. This paper presents the thermo-mechanical characterization of five aluminous dense commercial refractory (average density of 2.7 g / cm ³), used in such equipment. The results indicated that choosing the most suitable composition requires the evaluation of the microstructure aspects, such as porosity, permeability and pore size, and also the refractory's physical integrity, such as thermal shock resistance, abrasion resistance and high temperature modulus of rupture. The laboratory tests allowed the characterization of all the materials at the same conditions. Moreover, it was possible to optimize the selection of lining materials for melting and holding furnaces and to provide basis to a possible costs improvements synergy. (author)

  4. The influence of hold time on the onset of plastic deformation in silicon

    International Nuclear Information System (INIS)

    The transformation of diamond-cubic silicon to the metallic β-Sn phase is known to be “sluggish,” even when the critical pressure (∼11 GPa) for the transformation is reached. In this letter, we use nanoindentation to apply pressures to just above the critical threshold. In this regime, the sample displays purely elastic behavior at zero hold time. As the hold time at maximum load is increased up to 180 s, the percentage of indents that plastically deform also increase. Interestingly, the indents deform via one of two distinct processes: either via a phase transformation to a mixed bc8/r8-Si end phase, or by initiation of crystalline defects. Raman spectroscopy and cross-sectional transmission electron microscopy are used to show that the two deformation mechanisms are mutually exclusive under the indentation conditions presented here, and elastic modelling was utilized to propose a model for this mutually exclusive behavior. Hence, this behavior enhances the potential for application of the exotic bc8/r8-Si end phase

  5. Presumed Arterial Gas Embolism After Breath-Hold Diving in Shallow Water.

    Science.gov (United States)

    Harmsen, Stefani; Schramm, Dirk; Karenfort, Michael; Christaras, Andreas; Euler, Michael; Mayatepek, Ertan; Tibussek, Daniel

    2015-09-01

    Dive-related injuries are relatively common, but almost exclusively occur in recreational or scuba diving. We report 2 children with acute central nervous system complications after breath-hold diving. A 12-year-old boy presented with unilateral leg weakness and paresthesia after diving beneath the water surface for a distance of ∼25 m. After ascent, he suddenly felt extreme thoracic pain that resolved spontaneously. Neurologic examination revealed right leg weakness and sensory deficits with a sensory level at T5. Spinal MRI revealed a nonenhancing T2-hyperintense lesion in the central cord at the level of T1/T2 suggesting a spinal cord edema. A few weeks later, a 13-year-old girl was admitted with acute dizziness, personality changes, confusion, and headache. Thirty minutes before, she had practiced diving beneath the water surface for a distance of ∼25 m. After stepping out, she felt sudden severe thoracic pain and lost consciousness. Shortly later she reported headache and vertigo, and numbness of the complete left side of her body. Neurologic examination revealed reduced sensibility to all modalities, a positive Romberg test, and vertigo. Cerebral MRI revealed no pathologic findings. Both children experienced a strikingly similar clinical course. The chronology of events strongly suggests that both patients were suffering from arterial gas embolism. This condition has been reported for the first time to occur in children after breath-hold diving beneath the water surface without glossopharyngeal insufflation. PMID:26260715

  6. The Holding Company as an Instrument of Companies’ Tax-Financial Policy Formation

    OpenAIRE

    Dominik Gajewski

    2013-01-01

    The aim of this article is to present the holding institution as an economic and taxation solution. This article describes the holding company, indicates its advantages and disadvantages, and compares it to similar solutions. The main goal of holding companies is to change tax policies. As a result of these institutions, companies can change their tax status and economic situation. The holding institution influences the economic development of its constituent companies. The functioning of a h...

  7. 77 FR 45342 - Maxfield and Oberton Holdings, LLC; Complaint

    Science.gov (United States)

    2012-07-31

    ..., despite making no significant design or physical changes to the product since its introduction in 2009, Respondent subsequently rebranded Buckyballs as an adult executive desk toy and/or stress reliever, marketing... the products. 29. Since recalling Buckyballs , Respondent agreed to certain labeling and...

  8. Holding On to Our Kids in a Peer Culture

    Science.gov (United States)

    Mate, Gabor

    2010-01-01

    The chief and most damaging of the competing attachments undermining parental and elder authority and love is the increasing bonding of children with their peers. The disorder affecting today's young children and adolescents is rooted in their loss of orientation toward the nurturing adults in their lives. For the first time in history, young…

  9. Rationale for the Design of a Web-based Programming Course for Adults

    DEFF Research Database (Denmark)

    Bennedsen, Jens; Caspersen, Michael Edelgaard

    2003-01-01

    assistant as well as the other students. Another serious drawback is the reduced bandwidth in communication among the different actors. Precautions have to be taken in order to compensate for these and other drawbacks. We describe a web-based introductory programming course for adults and the rationale...... for choosing technologies and organizing the course in order to compensate for the drawbacks inherent in this kind of teaching. Our conclusions, although presented in the context of an introductory programming course, holds for most other construction-based courses as well. In the first part we set the stage...... by describing the relevant context and identifying the special conditions stemming from the course being an introductory programming course. In the second part we present a thorough discussion of the consequences of converting to a webbased course. Based on these consequences, we discuss what is meant...

  10. Analysis of spread and persistence for stream insects with winged adult stages.

    Science.gov (United States)

    Vasilyeva, Olga; Lutscher, Frithjof; Lewis, Mark

    2016-03-01

    Species such as stoneflies have complex life history details, with larval stages in the river flow and adult winged stages on or near the river bank. Winged adults often bias their dispersal in the upstream direction, and this bias provides a possible mechanism for population persistence in the face of unidirectional river flow. We use an impulsive reaction-diffusion equation with non-local impulse to describe the population dynamics of a stream-dwelling organism with a winged adult stage, such as stoneflies. We analyze this model from a variety of perspectives so as to understand the effect of upstream dispersal on population persistence. On the infinite domain we use the perspective of weak versus local persistence, and connect the concept of local persistence to positive up and downstream spreading speeds. These spreading speeds, in turn are connected to minimum travelling wave speeds for the linearized operator in upstream and downstream directions. We show that the conditions for weak and local persistence differ, and describe how weak persistence can give rise to a population whose numbers are growing but is being washed out because it cannot maintain a toe hold at any given location. On finite domains, we employ the concept of a critical domain size and dispersal success approximation to determine the ultimate fate of the populations. A simple, explicit formula for a special case allows us to quantify exactly the difference between weak and local persistence. PMID:26376648

  11. 49 CFR 557.6 - Determination whether to hold a public hearing.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Determination whether to hold a public hearing... AND REMEDY OF DEFECTS § 557.6 Determination whether to hold a public hearing. (a) The Administrator... complaints; (4) The ability of the NHTSA to resolve the problem without holding a hearing; and (5)...

  12. 26 CFR 53.4943-3 - Determination of excess business holdings.

    Science.gov (United States)

    2010-04-01

    ... indirectly, of the power to direct or cause the direction of the management and policies of a business... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Determination of excess business holdings. 53... Business Holdings § 53.4943-3 Determination of excess business holdings. (a) Excess business...

  13. 10 CFR 2.1502 - Commission decision to hold legislative hearing.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Commission decision to hold legislative hearing. 2.1502... AND ISSUANCE OF ORDERS Legislative Hearings § 2.1502 Commission decision to hold legislative hearing. (a) The Commission may, in its discretion, hold a legislative hearing in either a...

  14. 26 CFR 1.954-2 - Foreign personal holding company income.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Foreign personal holding company income. 1.954... company income. (a) Computation of foreign personal holding company income—(1) Categories of foreign personal holding company income. For purposes of subpart F and the regulations under that subpart,...

  15. 46 CFR 154.300 - Segregation of hold spaces from other spaces.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Segregation of hold spaces from other spaces. 154.300 Section 154.300 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS... Equipment Ship Arrangements § 154.300 Segregation of hold spaces from other spaces. Hold spaces must...

  16. 14 CFR 417.218 - Hold-and-resume gate analysis.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Hold-and-resume gate analysis. 417.218..., DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.218 Hold-and-resume gate... analysis must construct a hold-and-resume gate for each populated or otherwise protected area. After...

  17. The Health of Aging Lesbian, Gay and Bisexual Adults in California

    OpenAIRE

    Wallace, Steven P; Cochran, Susan D.; Durazo, Eva M.; Ford, Chandra L.

    2011-01-01

    Research on the health of lesbian, gay and bisexual (LGB) adults generally overlooks the chronic conditions that are the most common health concerns of older adults. This brief presents unique population-level data on aging LGB adults (ages 50–70) documenting that they have higher rates of several serious chronic physical and mental health conditions compared to similar heterosexual adults. Although access to care appears similar for aging LGB and heterosexual adults, aging LGB adults general...

  18. The Health of Aging Lesbian, Gay and Bisexual Adults in California

    OpenAIRE

    Wallace, Steven P; Cochran, Susan D.; Durazo, Eva M.; Ford, Chandra L.

    2011-01-01

    Research on the health of lesbian, gay and bisexual (LGB) adults generally overlooks the chronic conditions that are the most common health concerns of older adults. This brief presents unique population-level data on aging LGB adults (ages 50-70) documenting that they have higher rates of several serious chronic physical and mental health conditions compared to similar heterosexual adults. Although access to care appears similar for aging LGB and heterosexual adults, aging LGB adults general...

  19. Understanding the Burden of Adult Female Acne

    OpenAIRE

    Tanghetti, Emil A.; Kawata, Ariane K.; Daniels, Selena R.; Yeomans, Karen; Burk, Caroline T; Callender, Valerie D.

    2014-01-01

    Objective: Typically regarded as an adolescent condition, acne among adult females is also prevalent. Limited data are available on the clinical characteristics and burden of adult female acne. The study objective was to describe clinical characteristics and psychosocial impact of acne in adult women. Design: Cross-sectional, web-based survey. Setting: Data were collected from a diverse sample of United States females. Participants: Women ages 25 to 45 years with facial acne (≥25 visible lesi...

  20. Results of Hg speciation testing on MCU strip effluent hold tank (SEHT) and decontaminated salt solution hold tank (DSSHT) materials

    Energy Technology Data Exchange (ETDEWEB)

    Bannochie, C. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-09-17

    The Savannah River National Laboratory (SRNL) was tasked with preparing and shipping samples for Hg speciation by Eurofins Frontier Global Sciences, Inc. in Seattle, WA on behalf of the Savannah River Remediation (SRR) Mercury Task Team.i,ii The tenth shipment of samples was designated to include Modular Caustic Side Solvent Extraction Unit (MCU) Strip Effluent Hold Tank (SEHT) and MCU Decontaminated Salt Solution Hold Tank (DSSHT) materials from processing Salt Batch 7b. The MCU SEHT (MCU-15-722) and DSSHT (MCU-15-709) samples were pulled on June 15, 2015. All MCU samples were received at SRNL on June 16, 2015. The DSSHT sample was moved the same day to refrigeration, while the SEHT sample was placed in the Shielded Cells. On July 9, 2015 it was opened and an aliquot diluted 1:100 with Eurofins deionized water and a portion of the diluted sample transferred to a Teflon® bottle prior to moving it to refrigeration that same day. All samples were kept in the dark and refrigerated until final dilutions were prepared for shipment to Eurofins.

  1. China will Hold Seminar to Greet the World Standards Day

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Here comes 2004, the 35th session of the World Standards Day. The theme of this session is"Standards Connect the World", which is precisely a good turning point not only for the domestic economy to connect rails gradually with international, but also for national government to consummate and strengthen the standardization management system, to advance standardization work, and to raise the standardization level, after China's entrance into the World Trade Organization. Therefore, when the 35th session of the World Standards Day is arriving, sponsored by the SAC (Standardization Administration of China) and organized by CAS (China Association for Standardization), China will hold a seminar on October 14 in the Great Hall of the People.

  2. Predictive maintenance for the heated hold-up tank

    International Nuclear Information System (INIS)

    We present a numerical method to compute an optimal maintenance date for the test case of the heated hold-up tank. The system consists of a tank containing a fluid whose level is controlled by three components: two inlet pumps and one outlet valve. A thermal power source heats up the fluid. The failure rates of the components depends on the temperature, the position of the three components monitors the liquid level in the tank and the liquid level determines the temperature. Therefore, this system can be modeled by a hybrid process where the discrete (components) and continuous (level, temperature) parts interact in a closed loop. We model the system by a piecewise deterministic Markov process, propose and implement a numerical method to compute the optimal maintenance date to repair the components before the total failure of the system

  3. Experimental determination of bone cortex holding power of orthopedic screw

    Directory of Open Access Journals (Sweden)

    Bolliger Neto Raul

    1999-01-01

    Full Text Available Cylindrical specimens of bone measuring 15 mm in diameter were obtained from the lateral cortical layer of 10 pairs of femurs and tibias. A central hole 3.2 mm in diameter was drilled in each specimen. The hole was tapped, and a 4.5 mm cortical bone screw was inserted from the outer surface. The montage was submitted to push-out testing up to a complete strip of the bone threads. The cortical thickness and rupture load were measured, and the shear stress was calculated. The results were grouped according to the bone segment from which the specimen was obtained. The results showed that bone cortex screw holding power is dependent on the bone site. Additionally, the diaphyseal cortical bone tissue is both quantitatively and qualitatively more resistant to screw extraction than the metaphyseal tissue.

  4. Apparatus for the ultrasonic examination of shroud hold down bolts

    International Nuclear Information System (INIS)

    A process of testing hold down bolts depending from the sides of a steam separator within a nuclear reactor is described the process comprising the steps of: maintaining the steam separator under water; moving the bolts to unlatch the bolts from brackets on the shroud adjacent the steam separator; providing a shoe having a piezoelectric device mounted to the bottom of the shoe and exposed upwardly; providing a remotely actuated clamp attached to the shoe overlying the piezoelectric device; providing a mount to the shoe for manipulating the shoe underwater in a depending relationship at the bottom end of a pole; providing a pole and attaching the pole to the shoe; manipulating the shoe to the bottom of the bolt; and clamping the shoe to the bolt; and testing the bolt with the piezoelectric device

  5. Acute Shoulder Injuries in Adults.

    Science.gov (United States)

    Monica, James; Vredenburgh, Zachary; Korsh, Jeremy; Gatt, Charles

    2016-07-15

    Acute shoulder injuries in adults are often initially managed by family physicians. Common acute shoulder injuries include acromioclavicular joint injuries, clavicle fractures, glenohumeral dislocations, proximal humerus fractures, and rotator cuff tears. Acromioclavicular joint injuries and clavicle fractures mostly occur in young adults as the result of a sports injury or direct trauma. Most nondisplaced or minimally displaced injuries can be treated conservatively. Treatment includes pain management, short-term use of a sling for comfort, and physical therapy as needed. Glenohumeral dislocations can result from contact sports, falls, bicycle accidents, and similar high-impact trauma. Patients will usually hold the affected arm in their contralateral hand and have pain with motion and decreased motion at the shoulder. Physical findings may include a palpable humeral head in the axilla or a dimple inferior to the acromion laterally. Reduction maneuvers usually require intra-articular lidocaine or intravenous analgesia. Proximal humerus fractures often occur in older patients after a low-energy fall. Radiography of the shoulder should include a true anteroposterior view of the glenoid, scapular Y view, and axillary view. Most of these fractures can be managed nonoperatively, using a sling, early range-of-motion exercises, and strength training. Rotator cuff tears can cause difficulty with overhead activities or pain that awakens the patient from sleep. On physical examination, patients may be unable to hold the affected arm in an elevated position. It is important to recognize the sometimes subtle signs and symptoms of acute shoulder injuries to ensure proper management and timely referral if necessary. PMID:27419328

  6. Adult Immunization

    Directory of Open Access Journals (Sweden)

    Omer Coskun

    2008-04-01

    Full Text Available Despite the many advances in modern medicine, each year thousands of people in the world die from diseases that are easily prevented by safe and effective vaccines. Few measures in preventive medicine are of such proven value and as easy to implement as routine immunization against infectious diseases. Prevention of infection by immunization is a lifelong process. There are a number of vaccines that all adults (¡I18 years require. There are also other vaccines that need to be tailored to meet individual variations in risk resulting from occupation, foreign travel, underlying illness, lifestyle and age. In this study, we tried to review this important subject. [TAF Prev Med Bull. 2008; 7(2: 159-166

  7. Adult Immunization

    Directory of Open Access Journals (Sweden)

    Omer Coskun

    2008-04-01

    Full Text Available Despite the many advances in modern medicine, each year thousands of people in the world die from diseases that are easily prevented by safe and effective vaccines. Few measures in preventive medicine are of such proven value and as easy to implement as routine immunization against infectious diseases. Prevention of infection by immunization is a lifelong process. There are a number of vaccines that all adults (¡I18 years require. There are also other vaccines that need to be tailored to meet individual variations in risk resulting from occupation, foreign travel, underlying illness, lifestyle and age. In this study, we tried to review this important subject. [TAF Prev Med Bull 2008; 7(2.000: 159-166

  8. Near-ultraviolet illumination inhibits the liquid holding recovery in Escherichia coli B

    International Nuclear Information System (INIS)

    Liquid holding recovery (LHR) consists of an increase in the survival of UV-irradiated cells when they are held under non-nutrient conditions before plating. In this study we investigated in E. coli B cells the effect of the growth inhibition induced by near UV (365 nm) illumination (groth delay, GD) before irradiation with UV-254 nm on the amplitude of LHR and the induction of an SOS function (filamentation) during the liquid period. Our results demosntrated that pre-illumination with near-UV inhibits LHR and the induction of filamentation when the cells are incubated in nutrient medium. Moreover, this inhibition is due to GD, an effect caused by a photoproduct in the E. coli t-RNA, the 8-13 link. (author). 11 refs, 1 fig, 1 tab

  9. Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat

    OpenAIRE

    Blanco-Calvo, Eduardo; Rivera, Patricia; Arrabal, Sergio; Vargas, Antonio; Pavón, Francisco Javier; Serrano, Antonia; Castilla-Ortega, Estela; Galeano, Pablo; Rubio, Leticia; Suárez, Juan; Rodriguez de Fonseca, Fernando

    2014-01-01

    Addiction to major drugs of abuse, such as cocaine, has recently been linked to alterations in adult neurogenesis in the hippocampus. The endogenous cannabinoid system modulates this proliferative response as demonstrated by the finding that pharmacological activation/blockade of cannabinoid CB1 and CB2 receptors not only modulates neurogenesis but also modulates cell death in the brain. In the present study, we evaluated whether the endogenous cannabinoid system affects cocaine-induced alter...

  10. Pharmacological blockade of either, cannabinoid CB1 or CB2 receptors, prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rats.

    OpenAIRE

    EDUARDO eBLANCO-CALVO; PATRICIA eRIVERA; SERGIO eARRABAL; ANTONIO eVARGAS; FRANCISCO JAVIER ePAVON; ANTONIA eSERRANO; PABLO eGALEANO; LETICIA eRUBIO; JUAN eSUAREZ; FERNANDO eRODRIGUEZ DE FONSECA

    2014-01-01

    Addiction to major drugs of abuse such as cocaine has been recently linked to alterations on adult neurogenesis in the hippocampus. The endogenous cannabinoid system modulated this proliferative response since pharmacological activation/blockade of cannabinoid CB1 and CB2 receptors by modulating not only neurogenesis but also cell death in the brain. In the present study, we evaluated whether the endogenous cannabinoid system affects cocaine-induced alterations in cell proliferation . To this...

  11. Does the Coase theorem hold in real markets? An application to the negotiations between waterworks and farmers in Denmark

    DEFF Research Database (Denmark)

    Abildtrup, Jens; Jensen, Frank; Dubgaard, Alex

    2012-01-01

    The Coase theorem depends on a number of assumptions, among others, perfect information about each other’s payoff function, maximising behaviour and zero transaction costs. An important question is whether the Coase theorem holds for real market transactions when these assumptions are violated. T.......g. expropriation) may, under some conditions, be a more effective and cost efficient approach for the protection of vulnerable groundwater resources in Denmark.......The Coase theorem depends on a number of assumptions, among others, perfect information about each other’s payoff function, maximising behaviour and zero transaction costs. An important question is whether the Coase theorem holds for real market transactions when these assumptions are violated...

  12. Effect of Holding Time Before Solidification on Double-Oxide Film Defects and Mechanical Properties of Aluminum Alloys

    Science.gov (United States)

    El-Sayed, Mahmoud Ahmed; Salem, Hanadi A. G.; Kandeil, Abdelrazek Youssef; Griffiths, W. D.

    2011-12-01

    Double-oxide films (bifilms) have been held responsible for the variability in mechanical properties of aluminum castings. It has been suggested that the air entrapped inside a bifilm can react with the surrounding melt, leading to its consumption, which might improve the mechanical properties of the castings. In this work the effect of holding the melt before solidification on the distribution of mechanical properties, and by implication on entrained double oxide films, was investigated for several different aluminum alloys. The Weibull moduli of plate castings were determined under tensile conditions, and their fracture surfaces were examined for evidence of oxide films. The results suggested the occurrence of two competing mechanisms during the holding treatment: (1) the consumption of air inside the bifilms by reaction with the surrounding molten metal that may lead to improvements in mechanical properties and (2) the accompanying diffusion of hydrogen into the bifilms, which would be expected to have a deleterious effect on properties.

  13. Conscious Choking: Adult and Child

    Medline Plus

    Full Text Available ... and AED LIFEGUARDING Refresher Conscious Choking—Adult and Child (2:25) QUICK LINKS Home RedCross.org Purchase Course Materials Shop Our Store Contact Us Privacy Policy Terms and Conditions All rights reserved. 2011 American National Red Cross.

  14. SU-E-J-62: Breath Hold for Left-Sided Breast Cancer: Visually Monitored Deep Inspiration Breath Hold Amplitude Evaluated Using Real-Time Position Management

    Energy Technology Data Exchange (ETDEWEB)

    Conroy, L; Quirk, S; Smith, WL [The University of Calgary, Calgary, AB (Canada); Tom Baker Cancer Centre, Calgary, AB (Canada); Yeung, R; Phan, T [The University of Calgary, Calgary, AB (Canada); Hudson, A [Tom Baker Cancer Centre, Calgary, AB (Canada)

    2015-06-15

    Purpose: We used Real-Time Position Management (RPM) to evaluate breath hold amplitude and variability when gating with a visually monitored deep inspiration breath hold technique (VM-DIBH) with retrospective cine image chest wall position verification. Methods: Ten patients with left-sided breast cancer were treated using VM-DIBH. Respiratory motion was passively collected once weekly using RPM with the marker block positioned at the xiphoid process. Cine images on the tangent medial field were acquired on fractions with RPM monitoring for retrospective verification of chest wall position during breath hold. The amplitude and duration of all breath holds on which treatment beams were delivered were extracted from the RPM traces. Breath hold position coverage was evaluated for symmetric RPM gating windows from ± 1 to 5 mm centered on the average breath hold amplitude of the first measured fraction as a baseline. Results: The average (range) breath hold amplitude and duration was 18 mm (3–36 mm) and 19 s (7–34 s). The average (range) of amplitude standard deviation per patient over all breath holds was 2.7 mm (1.2–5.7 mm). With the largest allowable RPM gating window (± 5 mm), 4 of 10 VM-DIBH patients would have had ≥ 10% of their breath hold positions excluded by RPM. Cine verification of the chest wall position during the medial tangent field showed that the chest wall was greater than 5 mm from the baseline in only 1 out of 4 excluded patients. Cine images verify the chest wall/breast position only, whether this variation is acceptable in terms of heart sparing is a subject of future investigation. Conclusion: VM-DIBH allows for greater breath hold amplitude variability than using a 5 mm gating window with RPM, while maintaining chest wall positioning accuracy within 5 mm for the majority of patients.

  15. SU-E-J-62: Breath Hold for Left-Sided Breast Cancer: Visually Monitored Deep Inspiration Breath Hold Amplitude Evaluated Using Real-Time Position Management

    International Nuclear Information System (INIS)

    Purpose: We used Real-Time Position Management (RPM) to evaluate breath hold amplitude and variability when gating with a visually monitored deep inspiration breath hold technique (VM-DIBH) with retrospective cine image chest wall position verification. Methods: Ten patients with left-sided breast cancer were treated using VM-DIBH. Respiratory motion was passively collected once weekly using RPM with the marker block positioned at the xiphoid process. Cine images on the tangent medial field were acquired on fractions with RPM monitoring for retrospective verification of chest wall position during breath hold. The amplitude and duration of all breath holds on which treatment beams were delivered were extracted from the RPM traces. Breath hold position coverage was evaluated for symmetric RPM gating windows from ± 1 to 5 mm centered on the average breath hold amplitude of the first measured fraction as a baseline. Results: The average (range) breath hold amplitude and duration was 18 mm (3–36 mm) and 19 s (7–34 s). The average (range) of amplitude standard deviation per patient over all breath holds was 2.7 mm (1.2–5.7 mm). With the largest allowable RPM gating window (± 5 mm), 4 of 10 VM-DIBH patients would have had ≥ 10% of their breath hold positions excluded by RPM. Cine verification of the chest wall position during the medial tangent field showed that the chest wall was greater than 5 mm from the baseline in only 1 out of 4 excluded patients. Cine images verify the chest wall/breast position only, whether this variation is acceptable in terms of heart sparing is a subject of future investigation. Conclusion: VM-DIBH allows for greater breath hold amplitude variability than using a 5 mm gating window with RPM, while maintaining chest wall positioning accuracy within 5 mm for the majority of patients

  16. Brain tumor - primary - adults

    Science.gov (United States)

    ... Vestibular schwannoma (acoustic neuroma) - adults; Meningioma - adults; Cancer - brain tumor (adults) ... Primary brain tumors include any tumor that starts in the brain. Primary brain tumors can start from brain cells, ...

  17. Brain tumor - primary - adults

    Science.gov (United States)

    ... Vestibular schwannoma (acoustic neuroma) - adults; Meningioma - adults; Cancer - brain tumor (adults) ... wireless devices Head injuries Smoking Hormone therapy SPECIFIC TUMOR TYPES Brain tumors are classified depending on: Location of the ...

  18. Adult Still's disease

    Science.gov (United States)

    Still's disease - adult; AOSD ... than 1 out of 100,000 people develop adult-onset Still's disease each year. It affects women more often than men. The cause of adult Still's disease is unknown. No risk factors for ...

  19. Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.

    Science.gov (United States)

    Lafkas, Daniel; Shelton, Amy; Chiu, Cecilia; de Leon Boenig, Gladys; Chen, Yongmei; Stawicki, Scott S; Siltanen, Christian; Reichelt, Mike; Zhou, Meijuan; Wu, Xiumin; Eastham-Anderson, Jeffrey; Moore, Heather; Roose-Girma, Meron; Chinn, Yvonne; Hang, Julie Q; Warming, Søren; Egen, Jackson; Lee, Wyne P; Austin, Cary; Wu, Yan; Payandeh, Jian; Lowe, John B; Siebel, Christian W

    2015-12-01

    Prevailing dogma holds that cell-cell communication through Notch ligands and receptors determines binary cell fate decisions during progenitor cell divisions, with differentiated lineages remaining fixed. Mucociliary clearance in mammalian respiratory airways depends on secretory cells (club and goblet) and ciliated cells to produce and transport mucus. During development or repair, the closely related Jagged ligands (JAG1 and JAG2) induce Notch signalling to determine the fate of these lineages as they descend from a common proliferating progenitor. In contrast to such situations in which cell fate decisions are made in rapidly dividing populations, cells of the homeostatic adult airway epithelium are long-lived, and little is known about the role of active Notch signalling under such conditions. To disrupt Jagged signalling acutely in adult mammals, here we generate antibody antagonists that selectively target each Jagged paralogue, and determine a crystal structure that explains selectivity. We show that acute Jagged blockade induces a rapid and near-complete loss of club cells, with a concomitant gain in ciliated cells, under homeostatic conditions without increased cell death or division. Fate analyses demonstrate a direct conversion of club cells to ciliated cells without proliferation, meeting a conservative definition of direct transdifferentiation. Jagged inhibition also reversed goblet cell metaplasia in a preclinical asthma model, providing a therapeutic foundation. Our discovery that Jagged antagonism relieves a blockade of cell-to-cell conversion unveils unexpected plasticity, and establishes a model for Notch regulation of transdifferentiation. PMID:26580007

  20. Chronic Cough in Adults (Beyond the Basics)

    Science.gov (United States)

    ... of Use ©2016 UpToDate, Inc. Patient education: Chronic cough in adults (Beyond the Basics) Authors Ronald C ... and helps to prevent infection. However, sometimes a cough can become a chronic condition. A chronic cough ...

  1. Accountability in Teenage Dating Violence: A Comparative Examination of Adult Domestic Violence and Juvenile Justice Systems Policies

    Science.gov (United States)

    Zosky, Diane L.

    2010-01-01

    Unlike in the adult criminal justice system, where domestic violence policies hold perpetrators accountable for their violence, the juvenile justice system rarely addresses teenage dating violence. Although the adult criminal justice system has pursued policies toward intimate partner violence grounded on a "zero tolerance" ideology, the juvenile…

  2. Performance in Older Adults

    Directory of Open Access Journals (Sweden)

    David Predovan

    2012-01-01

    Full Text Available Growing evidence supports the use of physical training interventions to improve both physical and cognitive performances in healthy older adults. Few studies have examined the impact of aerobic exercise on Stroop task performance, a measure of executive functions. In the current 3-month aerobic training study, 50 older adults (mean age = 67.96 ± 6.25 years were randomly assigned to either a three-month physical training group or to a control group (waiting list. Training sessions were 3 times per week for 60 minutes. All participants completed pre- and post-test measures of cognitive performance using the modified Stroop task and physical performance (Rockport one-mile test. Compared to controls, the training group showed significant improvements in physical capacity (P<0.001 and enhanced Stroop performance, but only in the inhibition/switching condition (P<0.03. Furthermore, the increase in aerobic capacity induced by the training regimen correlated negatively with reaction time in the inhibition/switching condition of the Stroop task at posttest (r=−0.538; P=0.007. Importantly, the reported gains in cognitive performance were observed after only three months of physical training. Taken together, the results suggest that even short-term physical interventions can enhance older adults’ executive functions.

  3. Mice lacking the PSD-95–interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning

    OpenAIRE

    Hanwool Park; Jinhee Yang; Ryunhee Kim; Yan Li; Yeunkum Lee; Chungwoo Lee; Jongil Park; Dongmin Lee; Hyun Kim; Eunjoon Kim

    2015-01-01

    Protein ubiquitination has a significant influence on diverse aspects of neuronal development and function. Dorfin, also known as Rnf19a, is a RING finger E3 ubiquitin ligase implicated in amyotrophic lateral sclerosis and Parkinson’s disease, but its in vivo functions have not been explored. We report here that Dorfin is a novel binding partner of the excitatory postsynaptic scaffolding protein PSD-95. Dorfin-mutant (Dorfin −/−) mice show reduced adult neurogenesis and enhanced long-term pot...

  4. Portal venous blood flow while breath-holding after inspiration or expiration and during normal respiration in controls and cirrhotics

    International Nuclear Information System (INIS)

    In this study, we used magnetic resonance (MR) imaging to measure portal blood flow in 12 healthy controls and 17 cirrhotics while they were breath-holding after inspiration and after expiration. We then compared the results with measurements made during normal respiration in the healthy controls and cirrhotics. Blood flow in the main portal vein under basal fasting conditions was quantitated using the cine phase-contrast MR velocity mapping method. Three measurements were made on one occasion, as follows: throughout the cardiac cycle during normal respiration, with the subject breath-holding after maximal inspiration, and with the subject breath-holding after maximal expiration. During normal respiration, portal blood flow was 1.3±0.2 l/min in controls vs 1.0±0.1 l/min in cirrhotics (P<0.0001); while subjects were breath-holding after inspiration, portal blood flow was 1.0±0.2 l/min in controls vs 0.9±0.1 l/min in cirrhotics; and while subjects were breath-holding after expiration, portal blood flow was 1.5±0.2 l/min in controls vs 1.1±0.2 l/min in cirrhotics (P<0.0001). The differences were primarily due to changes in flow velocity. When the magnitude of these hemodynamic changes in the three respiratory conditions was compared in controls and cirrhotics, analysis of variance (ANOVA) showed a significant difference (P<0.0001). In controls, portal blood flow decreased during maximal inspiration relative to flow during normal respiration (-24.6±8.3%). Changes in portal blood flow in controls were greater than in cirrhotics (-13.5±4.5%) (P<0.0001); however, the difference in blood flow increase associated with maximal expiration between the two groups (+11.8±9.4% vs +5.9±11.5%) was not significant. We found that the respiration-induced hemodynamic variation in portal blood flow was less in cirrhotics than in the healthy controls. Portal blood flow measurements made during normal respiration using MR imaging closely reflect nearly physiologic conditions

  5. Portal venous blood flow while breath-holding after inspiration or expiration and during normal respiration in controls and cirrhotics

    Energy Technology Data Exchange (ETDEWEB)

    Sugano, Shigeo; Yamamoto, Kunihiro; Sasao, Ken-ichiro; Watanabe, Manabu [Saiseikai Wakakusa Hospital, Yakohama (Japan)

    1999-07-01

    In this study, we used magnetic resonance (MR) imaging to measure portal blood flow in 12 healthy controls and 17 cirrhotics while they were breath-holding after inspiration and after expiration. We then compared the results with measurements made during normal respiration in the healthy controls and cirrhotics. Blood flow in the main portal vein under basal fasting conditions was quantitated using the cine phase-contrast MR velocity mapping method. Three measurements were made on one occasion, as follows: throughout the cardiac cycle during normal respiration, with the subject breath-holding after maximal inspiration, and with the subject breath-holding after maximal expiration. During normal respiration, portal blood flow was 1.3{+-}0.2 l/min in controls vs 1.0{+-}0.1 l/min in cirrhotics (P<0.0001); while subjects were breath-holding after inspiration, portal blood flow was 1.0{+-}0.2 l/min in controls vs 0.9{+-}0.1 l/min in cirrhotics; and while subjects were breath-holding after expiration, portal blood flow was 1.5{+-}0.2 l/min in controls vs 1.1{+-}0.2 l/min in cirrhotics (P<0.0001). The differences were primarily due to changes in flow velocity. When the magnitude of these hemodynamic changes in the three respiratory conditions was compared in controls and cirrhotics, analysis of variance (ANOVA) showed a significant difference (P<0.0001). In controls, portal blood flow decreased during maximal inspiration relative to flow during normal respiration (-24.6{+-}8.3%). Changes in portal blood flow in controls were greater than in cirrhotics (-13.5{+-}4.5%) (P<0.0001); however, the difference in blood flow increase associated with maximal expiration between the two groups (+11.8{+-}9.4% vs +5.9{+-}11.5%) was not significant. We found that the respiration-induced hemodynamic variation in portal blood flow was less in cirrhotics than in the healthy controls. Portal blood flow measurements made during normal respiration using MR imaging closely reflect nearly

  6. Leaning in and holding on: team support with unexpected death.

    Science.gov (United States)

    Kobler, Kathie

    2014-01-01

    Integral to the care of medically fragile infants and children is the sobering reality that not all will survive. Supporting children and families through the dying process requires knowledge, skill, compassion, and a willingness to be present to the suffering of others. As healthcare professionals journey with a dying child, they experience an ongoing dual nature of their own grief, shifting between focusing on the loss at hand or avoiding the loss and refocusing their attention elsewhere. This internal conflict may be potentiated with the sudden, unexpected death of a patient, which affords little time for caregivers to process their own experience of the loss. When an unanticipated death occurs, a palpable grief ripples through the entire unit, impacting caregivers, the bereaved parents, and other patients and families. Such an event holds the potential for either team disorganization or growth. This article presents a case study of one unit's response to the unexpected death of a long-term patient, which caused caregivers to lean in to support each other. Using a case study approach, the author identifies strategies to best guide teams when death arrives without warning, and provides ideas for cocreating ritual to honor relationship in the midst of tragedy. PMID:24445436

  7. Recent Ground Hold and Rapid Depressurization Testing of Multilayer Systems

    Science.gov (United States)

    Johnson, Wesley L.

    2014-01-01

    In the development of flight insulation systems for large cryogenic orbital storage (spray on foam and multilayer insulation), testing need include all environments that are experienced during flight. While large efforts have been expended on studying, bounding, and modeling the orbital performance of the insulation systems, little effort has been expended on the ground hold and ascent phases of a mission. Historical cryogenic in-space systems that have flown have been able to ignore these phases of flight due to the insulation system being within a vacuum jacket. In the development phase of the Nuclear Mars Vehicle and the Shuttle Nuclear Vehicle, several insulation systems were evaluated for the full mission cycle. Since that time there had been minimal work on these phases of flight until the Constellation program began investigating cryogenic service modules and long duration upper stages. With the inception of the Cryogenic Propellant Storage and Transfer Technology Demonstration Mission, a specific need was seen for the data and as such, several tests were added to the Cryogenic Boil-off Reduction System liquid hydrogen test matrix to provide more data on a insulation system. Testing was attempted with both gaseous nitrogen (GN2) and gaseous helium (GHe) backfills. The initial tests with nitrogen backfill were not successfully completed due to nitrogen liquefaction and solidification preventing the rapid pumpdown of the vacuum chamber. Subsequent helium backfill tests were successful and showed minimal degradation. The results are compared to the historical data.

  8. Committee monitors mission vitality in local holding companies.

    Science.gov (United States)

    Clifton, R

    1987-01-01

    Although consciousness of a religious institute's sponsorship or mission in the nineteenth and early twentieth centuries was secondary to the more important function of religious formation, the health care environment in recent years has demanded a closer attention to mission. Religious institutes have identified the need to further articulate statements of mission and philosophy and to develop mechanisms to evaluate their effectiveness in promoting the community's values. In response to this need, Bon Secours Health System, Columbia, MD, developed a standing committee, the mission committee, to oversee the mission activities of the entities within each of its local holding companies. Among its responsibilities are the periodic review of programs, the monitoring of social justice actions in which the local corporation may be involved, the recommendation of policy concerning ethical and medical-moral issues to the board of directors, and the identification of educational need in these areas. A special focus on the system's mission activity has been indigent care, an area that the mission committee both monitors and directs. As a governance structure, the mission committee complements rather than detracts from the chief executive officer's responsibility for mission. Since its creation in 1983, it has proved valuable not only in ensuring the system's mission effectiveness but also in integrating the operations and mission perspectives. PMID:10280362

  9. The development of a Space Shuttle Research Animal Holding Facility

    Science.gov (United States)

    Jagow, R. B.

    1980-01-01

    The ability to maintain the well being of experiment animals is of primary importance to the successful attainment of life sciences flight experiment goals. To assist scientists in the conduct of life sciences flight experiments, a highly versatile Research Animal Holding Facility (RAHF) is being developed for use on Space Shuttle/Spacelab missions. This paper describes the design of the RAHF system, which in addition to providing general housing for various animal species, approximating the environment found in ground based facilities, is designed to minimize disturbances of the specimens by vehicle and mission operations. Life-sustaining capabilities such as metabolic support and environmental control are provided. RAHF is reusable and is a modular concept to accommodate animals of different sizes. The basic RAHF system will accommodate a combination of 24 500-g rats or 144 mice or a mixed number of rats and mice. An alternative design accommodates four squirrel monkeys. The entire RAHF system is housed in a single ESA rack. The animal cages are in drawers which are removable for easy access to the animals. Each cage contains a waste management system, a feeding system and a watering system all of which will operate in zero or one gravity.

  10. Participation patterns in adult education

    DEFF Research Database (Denmark)

    Desjardins, Richard; Rubenson, Kjell

    2013-01-01

    This article focuses on evidence regarding cross-national patterns of participation in adult education and an interpretation of these patterns from an institutional and public policy perspective. The interpretation follows from the perspective that sustaining high and widely distributed levels of...... problems that otherwise lead to underinvestment in skills and/or inequity in the distribution of access to education and training and hence skills. Hence, it is argued that institutional contexts and public policy measures condition participation patterns in adult education, and are thus worthwhile to...

  11. Method of mechanical holding of cantilever chip for tip-scan high-speed atomic force microscope

    International Nuclear Information System (INIS)

    In tip-scan atomic force microscopy (AFM) that scans a cantilever chip in the three dimensions, the chip body is held on the Z-scanner with a holder. However, this holding is not easy for high-speed (HS) AFM because the holder that should have a small mass has to be able to clamp the cantilever chip firmly without deteriorating the Z-scanner’s fast performance, and because repeated exchange of cantilever chips should not damage the Z-scanner. This is one of the reasons that tip-scan HS-AFM has not been established, despite its advantages over sample stage-scan HS-AFM. Here, we present a novel method of cantilever chip holding which meets all conditions required for tip-scan HS-AFM. The superior performance of this novel chip holding mechanism is demonstrated by imaging of the α3β3 subcomplex of F1-ATPase in dynamic action at ∼7 frames/s

  12. Effects of holding temperature and time on semi-solid isothermal heat-treated microstructure of ZA84 magnesium alloy

    Institute of Scientific and Technical Information of China (English)

    YANG Ming-bo; PAN Fu-sheng; CHENG Ren-ju; SHEN Jia

    2008-01-01

    The feasibility of fabricating ZA84 magnesium alloy with non-dendritic microstructure by a semi-solid isothermal heat treatment process and the effects of holding temperature and time on the semi-solid isothermal heat-treated microstructure of the alloy were investigated. The results indicate that it is possible to produce ZA84 alloy with non-dendritic microstructure by suitable semi-solid isothermal heat treatment. After being treated at 560-575℃ for 120min, ZA84 magnesium alloy can obtain a non-dendritic microstructure with 14.2%-25.6% liquid fraction and an average size of 56-65μm of the unmelted primary solid particles. With the increasing holding time from 30 to 120min or holding temperature from 560 to 575℃, the average size of unmelted primary solid particles decreases and globular tendency becomes more obvious. Under the experimental condition, the microstructural evolution of ZA84 alloy during semi-solid isothermal treatment is mainly composed of three stages of initial coarsening. structulseparation and spheroidization. The subsequent coarsening of spheroidal grains is not observed.

  13. Development of Small-sized Fluid Control Valve with Self-holding Function Using Permanent Magnet

    Science.gov (United States)

    Akagi, Tetsuya; Dohta, Shujiro; Ueda, Hirofumi

    Recently, force feedback devices in virtual reality and power assisted nursing care systems have received much attention and active research. In such a control system, an actuator and a driving device such as a control valve are mounted on the human body. In this condition, the size and weight of the control valve become serious problems. At the same time, the valve should be operated with lower energy consumption because of using a limited electrical power. The typical electro magnetic solenoid valve drives its spool using a larger solenoid to open the valve. The complex construction of the valve for sealing makes its miniaturization and the fabrication of a low cost valve more difficult. In addition, the solenoid in the valve consumes more electrical power while the valve is kept opening. The purpose of our study is to develop a small-sized, lightweight, lower energy consumption and flexible control valve that can be safe enough to mount on the human body at a lower cost. In our pervious study, we proposed and tested the control valve that can open using a vibration motor. In this study, we propose and test a new type of fluid control valve with a self-holding function. The new valve uses a permanent magnet ball. It has a cylindrical magnet and two solenoids. The self-holding function of the valve is done as follows. When one side of the solenoid is stimulated by the current momentarily, the solenoid gives a repulsive force to the cylindrical magnet. The magnet moves toward the opposite side of the solenoid and is attracted to the iron core. Then, the magnet ball moves toward the cylindrical magnet and opens the orifice. The valve can keep open without electrical energy. As a result, the valve with the extremely lower energy consumption can be developed.

  14. Assessing Water Temperature Zones in Idealized Holding Pools for Chinook Salmon: A Hypothetical Study Based on the Regulated Lower San Joaquin River

    Science.gov (United States)

    Sivakumaran, K.; Villamizar, S. R.; Pai, H.; Aguilar, A.; Harmon, T. C.

    2014-12-01

    In regulated rivers such as the Lower San Joaquin River (LSJR) in California, environmental policy requires releasing adequate flows to maintain habitat quality for flora and fauna. The prescribed reservoir releases on the LSJR are tied to water year classifications in order to help satisfy competing water demands in dry years. The question remains as to whether relatively low releases will be adequate to maintain habitat quality for key aquatic species under current and projected climate conditions. This work examines one critical determinant of anadromous fish habitat suitability, water temperature, as a function of reservoir release conditions. More specifically, we study idealized pools subject to the conditions of the LSJR using an established 2D (longitudinal and vertical) flow and heat transport model (CE-QUAL-W2). We assessed the releases in the context of the spring run Chinook salmon (Onchorhynchus tshawytscha) life cycle (the key species in an ongoing restoration effort), focusing on summer holding conditions. Our objective was to determine the conditions under which pools provide sufficiently cool havens for the holding salmon under current and projected climate conditions. Using river bathymetry from measured cross-sections and a high-resolution DEM lidar product, we created a range of ideal pool size representative of LSJR conditions. After calibrating hydraulic and heat transfer parameters using available temperature profiles, we simulated temperature profiles in the pools for scheduled flow releases, at different downstream locations from the reservoir. Results include modeled temperature profiles in holding pools, and derived estimates of suitable holding capacity under a range of pool, releases and climate conditions. Potential engineering modifications are explored as potential mitigation strategies, such as modified flow schedules, riparian shading, pool sizes and pool relocations.

  15. Covariant jump conditions in electromagnetism

    International Nuclear Information System (INIS)

    A generally covariant four-dimensional representation of Maxwell’s electrodynamics in a generic material medium can be achieved straightforwardly in the metric-free formulation of electromagnetism. In this setup, the electromagnetic phenomena are described by two tensor fields, which satisfy Maxwell’s equations. A generic tensorial constitutive relation between these fields is an independent ingredient of the theory. By use of different constitutive relations (local and non-local, linear and non-linear, etc.), a wide area of applications can be covered. In the current paper, we present the jump conditions for the fields and for the energy–momentum tensor on an arbitrarily moving surface between two media. From the differential and integral Maxwell equations, we derive the covariant boundary conditions, which are independent of any metric and connection. These conditions include the covariantly defined surface current and are applicable to an arbitrarily moving smooth curved boundary surface. As an application of the presented jump formulas, we derive a Lorentzian type metric as a condition for existence of the wave front in isotropic media. This result holds for ordinary materials as well as for metamaterials with negative material constants. - Highlights: ► Covariant metric-free jump conditions for the electromagnetic field are derived. ► Covariantly defined surface current is considered. ► Lorentzian type metric from existence of the wave front in isotropic media. ► The result holds for ordinary materials as well as for metamaterials.

  16. Child Adversity, Adult Intimate Partner Violence and Inflammation in Young Adults

    OpenAIRE

    Dellor, Elinam Dzifa

    2016-01-01

    Negative childhood experiences and adult intimate partner violence may leave individuals vulnerable to poor mental and physical health in adulthood. Victims of emotional abuse and intimate partner violence have a higher risk of developing chronic medical conditions in adult life, including cardiovascular disease. Similarly, adults who lived in poverty as children have higher risk of cardiovascular disease. The immune system releases acute-phase proteins such as C-reactive protein (CRP) not o...

  17. Why do holding companies in pyramidal groups trade at a discount?

    OpenAIRE

    ROMMENS, An; DELOOF, Marc; Jegers, Marc

    2004-01-01

    Holding companies, which play an important role in corporate finance in Belgium and in other Continental European countries, often trade at a discount to their estimated net asset value (NAV). First, we discuss possible explanations for this discount: holding company destroys value, NAV overestimates actual value, noise traders cause underpricing, and private benefits of control. Second, we investigate the discount of the Belgian holding company Cobepa, for which detailed information on the c...

  18. Dosimetric and clinical advantages of deep inspiration breath-hold (DIBH) during radiotherapy of breast cancer

    OpenAIRE

    Bruzzaniti, Vicente; Abate, Armando; Pinnarò, Paola; D’Andrea, Marco; Infusino, Erminia; Landoni, Valeria; Soriani, Antonella; Giordano, Carolina; Ferraro, Anna Maria; Strigari, Lidia

    2013-01-01

    Background To investigate the potential dosimetric and clinical benefits of Deep Inspiration Breath-Hold (DIBH) technique during radiotherapy of breast cancer compared with Free Breathing (FB). Methods Eight left-sided breast cancer patients underwent a supervised breath hold during treatment. For each patient, two CT scans were acquired with and without breath hold, and virtual simulation was performed for conventional tangential fields, utilizing 6 or 15 MV photon fields. The resulting dose...

  19. Trend Definition or Holding Strategy: What Determines the Profitability of Candlestick Technical Trading Strategies?

    OpenAIRE

    Tsung-Hsun Lu; Yi-Chi Chen; Yu-Chin Hsu

    2014-01-01

    We ask what determines the profitability of candlestick patterns. Is it the definition of trend and/or the holding strategy that one uses in candlestick charting analysis? To answer this, we conduct a systematic investigation by considering three definitions of trend and four holding strategies. Based on the DJIA components data, we find that eight three-day reversal patterns with a Caginalp-Laurent holding strategy are profitable after we account for data-snooping bias. We also find that our...

  20. Pneumomediastinum is induced during glossopharyngeal insufflation in breath-hold divers.

    OpenAIRE

    2010-01-01

    In breath-hold diving as in ordinary scuba diving, there are reported incidents of serious neurological symptoms, mimicking cerebral insults. The etiology for the symptoms in breath-hold diving is uncertain. It has been speculated that it may be due to decompression sickness, provided that there is enough nitrogen in tissue to cause supersaturation. However, as far as we are aware of, such venous gas bubbles have not been demonstrated. Neurological symptoms during breath-hold diving may also ...

  1. EFFECTS OF ORAL IRON SUPPLEMENT ON BREATH-HOLDING SPELLS IN CHILDREN

    OpenAIRE

    S.H. TONEKABONI MD; S. Alavi MD; F. Mahvelati MD; Z. TABASI MD

    2009-01-01

    Objectives:Breath holding spells are one of the most frequent and important diagnostic challenges in pediatrics. The aim of this study, conducted on pediatric patients referring to the pediatric neurology clinic in Hormozgan province, was to evaluate therapeutic effects of iron on breath holding spellsMaterials and Methods:35 children (19 males and 16 females), aged between 3 to 60 months, with a history of breath-holding spells, were included in the trial. To obtain all relevant data a speci...

  2. International Holding Company as an Optimal Structure for Optimizing Tax Liabilities of Taxpayers

    OpenAIRE

    E. K. Garaeva

    2015-01-01

    The paper analyzes the tax issues of holding companies using the example of the EU countries. The articledescribes and studies a number of ways to optimize the taxation of international holding companies; discussesthe challenges currently faced by the tax authorities of different countries in the implementation of tax controlover the functioning of the integrated structures. The paper considers advantages and disadvantages of taxoptimization of international holding companies, the cost of com...

  3. Liquid holding recovery and photoreactivation of the ultraviolet-inactivated vibrios

    International Nuclear Information System (INIS)

    The kinetics of liquid holding recovery and photoreactivation of the ultra-violet-inactivated vibrios have been investigated. Photoreactivation was highest (about 80%) for Vibrio cholerae (classical) strains but the liquid holding recovery was highest (about 29%) for Vibrio parahemolyticus ones. Significance of the differences between any two of the four vibrio biotypes in respect of their liquid holding recovery and also photoreactivation was analysed statistically. (auth.)

  4. The effects of breath-holding on pulmonary regurgitation measured by cardiovascular magnetic resonance velocity mapping

    OpenAIRE

    Babu-Narayan Sonya V; Johansson Bengt; Kilner Philip J

    2009-01-01

    Abstract Background Pulmonary regurgitation is a common and clinically important residual lesion after repair of tetralogy of Fallot. Cardiovascular magnetic resonance (CMR) phase contrast velocity mapping is widely used for measurement of pulmonary regurgitant fraction. Breath-hold acquisitions, usually acquired during held expiration, are more convenient than the non-breath-hold approach, but we hypothesized that breath-holding might affect the amount of pulmonary regurgitation. Methods For...

  5. Researching participation in adult education

    DEFF Research Database (Denmark)

    Kondrup, Sissel

    labour. This has fostered an interest in examining why and how people engage in adult education, how participation and especially non-participation in adult education can be explained and how participation rates can be increased. In this paper I outline different traditions within research on recruitment...... peoples’ learner identity – their perceived needs and opportunities to engage in different learning activities – is a result of their continuing experience process conditioned by their engagement in a specific historical, social and material work life.......It is a widespread perception that the challenge of increasing participation in adult education and training has intensified due to the transformation from industrial to knowledge based societies and the transformation implies that it becomes pivotal to increase the supply of highly qualified...

  6. Science in europe/the antinuclear movement takes hold.

    Science.gov (United States)

    Hawkes, N

    1977-09-16

    Five months after the announcement of President Carter's nonproliferation policy, the common wisdom in this country is that Europe has hardly wavered in its rush toward nuclear power. The cry that "Europe will do what it wants whether the United States builds a breeder or not" is often heard from American nuclear interests, with apparent justification as the State Department has shown little visible progress in negotiating new agreements and some signs of retreating from its original goals. But popular protest against nuclear power has reached a pitch in Europe that would be barely imaginable today in this country, and the political strength of the antinuclear forces has become formidable, not only in Sweden where nuclear power was a pivotal issue last year, but across the continent. West Germany's research minister recently predicted that that country's two ruling coalition parties will vote for a complete moratorium on nuclear construction when they meet this fall, and some observers predict that any moratorium contingent on creation of a waste disposal site could last up to 12 years. Beyond public opposition, the plutonium breeder is running into trouble in Germany for many of the same reasons it has in the United States; program delays, safety concerns, and cost overruns threaten to undermine the claim that it can one day become an economically competitive energy source. Nuclear opposition is far from being a single-issue movement in Europe, as groups of many political persuasions embrace it for their own reasons. But as the following report by Nigel Hawkes details, the Carter administration policy is not the only thing holding back nuclear power in Europe.-W.D.M. PMID:17753327

  7. Characterization plan for the waste holding basin (3513 impoundment)

    International Nuclear Information System (INIS)

    US Department of Energy (DOE) facilities are required to comply fully with all federal and state regulations. In response to this requirement, the Oak Ridge National Laboratory (ORNL) has established the remedial action program, to provide comprehensive management of areas where past research, development, and waste management activities have been conducted and have resulted in residual contamination of facilities or the environment. One of the objectives of this program is to define the extent of contamination at these sites. The intent is to document the known environmental characteristics of the sites and identify the additional actions, such as sampling, analytical measurements, and modeling, necessary to confirm contamination and the possible migration of contaminants from the sites. One of these sites is the waste holding basin (3513 impoundment). The 3513 impoundment is an unlined waste settling basin constructed in 1944 for collection of ORNL wastewater before its discharge into White Oak Creek. Operation of the facility ceased in 1976 when a new process waste treatment plant came into operation. Considerable site-specific environmental information has been developed over the years relative to the type and quantities of radionuclides and hazardous substances contained in the pond water and sediment. The concentrations and patterns of distribution for many of the radionuclides in the aquatic biota as well as for the terrestrial plants growing on the berm of the impoundment have been determined by DOE ecological studies. Recently, some data were collected that evaluate the extent of contaminant movement to the groundwater. Results from these studies are summarized in this report. Also included in this report is an outline of additional tasks needed to obtain the necessary information to model the transport and dose pathways of hazardous substances from the site

  8. Chromosomal Conditions

    Science.gov (United States)

    ... labor & premature birth The newborn intensive care unit (NICU) Birth defects & other health conditions Loss & grief Tools & ... labor & premature birth The newborn intensive care unit (NICU) Birth defects & other health conditions Loss & grief Ask ...

  9. Novel hold-release functionality in a P300 brain-computer interface

    Science.gov (United States)

    Alcaide-Aguirre, R. E.; Huggins, J. E.

    2014-12-01

    Assistive technology control interface theory describes interface activation and interface deactivation as distinct properties of any control interface. Separating control of activation and deactivation allows precise timing of the duration of the activation. Objective. We propose a novel P300 brain-computer interface (BCI) functionality with separate control of the initial activation and the deactivation (hold-release) of a selection. Approach. Using two different layouts and off-line analysis, we tested the accuracy with which subjects could (1) hold their selection and (2) quickly change between selections. Main results. Mean accuracy across all subjects for the hold-release algorithm was 85% with one hold-release classification and 100% with two hold-release classifications. Using a layout designed to lower perceptual errors, accuracy increased to a mean of 90% and the time subjects could hold a selection was 40% longer than with the standard layout. Hold-release functionality provides improved response time (6-16 times faster) over the initial P300 BCI selection by allowing the BCI to make hold-release decisions from very few flashes instead of after multiple sequences of flashes. Significance. For the BCI user, hold-release functionality allows for faster, more continuous control with a P300 BCI, creating new options for BCI applications.

  10. Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

    Science.gov (United States)

    Bartlett, Frederick R.; Colgan, Ruth M.; Donovan, Ellen M.; Carr, Karen; Landeg, Steven; Clements, Nicola; McNair, Helen A.; Locke, Imogen; Evans, Philip M.; Haviland, Joanne S.; Yarnold, John R.; Kirby, Anna M.

    2014-01-01

    Breath-holding techniques reduce the amount of radiation received by cardiac structures during tangential-field left breast radiotherapy. With these techniques, patients hold their breath while radiotherapy is delivered, pushing the heart down and away from the radiotherapy field. Despite clear dosimetric benefits, these techniques are not yet in widespread use. One reason for this is that commercially available solutions require specialist equipment, necessitating not only significant capital investment, but often also incurring ongoing costs such as a need for daily disposable mouthpieces. The voluntary breath-hold technique described here does not require any additional specialist equipment. All breath-holding techniques require a surrogate to monitor breath-hold consistency and whether breath-hold is maintained. Voluntary breath-hold uses the distance moved by the anterior and lateral reference marks (tattoos) away from the treatment room lasers in breath-hold to monitor consistency at CT-planning and treatment setup. Light fields are then used to monitor breath-hold consistency prior to and during radiotherapy delivery. PMID:25046661

  11. Tensile hold time effects on isothermal and thermal low-cycle fatigue of 304 stainless steel

    International Nuclear Information System (INIS)

    In high temperature low-cycle fatigue tests, it has often been noted that the fatigue life can be reduced, sometimes drastically, by imposing hold periods under tensile strain and that the effect increases with the length of the hold time. The generally accepted reason for this is that creep effects become more significant with time, and this has sometimes been substantiated by metallographic evidence of increasingly brittle intergranular fracture with increasing hold time or with decreasing cyclic frequency. This paper presents results of Isothermal and Thermal-Mechanical low-cyclic fatigue tests on 304 stainless steel with various tensile hold times. (author)

  12. Adult Neurogenesis in Drosophila

    OpenAIRE

    Ismael Fernández-Hernández; Christa Rhiner; Eduardo Moreno

    2013-01-01

    Adult neurogenesis has been linked to several cognitive functions and neurological disorders. Description of adult neurogenesis in a model organism like Drosophila could facilitate the genetic study of normal and abnormal neurogenesis in the adult brain. So far, formation of new neurons has not been detected in adult fly brains and hence has been thought to be absent in Drosophila. Here, we used an improved lineage-labeling method to show that, surprisingly, adult neurogenesis occurs in the m...

  13. Depression in Older Adults

    OpenAIRE

    Fiske, Amy; Wetherell, Julie Loebach; Gatz, Margaret

    2009-01-01

    Depression is less prevalent among older adults than among younger adults but can have serious consequences. Over half of cases represent a first onset in later life. Although suicide rates in the elderly are declining, they are still higher than in younger adults and more closely associated with depression. Depressed older adults are less likely to endorse affective symptoms and more likely to display cognitive changes, somatic symptoms, and loss of interest than are younger adults. Risk fac...

  14. Detrimental role of prolonged sleep deprivation on adult neurogenesis

    OpenAIRE

    Fernandes, Carina; Rocha, Nuno Barbosa F.; Rocha, Susana; Herrera-Solís, Andrea; Salas-Pacheco, José; García-García, Fabio; Murillo-Rodríguez, Eric; Yuan, Ti-Fei; Machado, Sergio; Arias-Carrión, Oscar

    2015-01-01

    Adult mammalian brains continuously generate new neurons, a phenomenon called adult neurogenesis. Both environmental stimuli and endogenous factors are important regulators of adult neurogenesis. Sleep has an important role in normal brain physiology and its disturbance causes very stressful conditions, which disrupt normal brain physiology. Recently, an influence of sleep in adult neurogenesis has been established, mainly based on sleep deprivation studies. This review provides an overview o...

  15. Investigation of Gas Hold up and Power Consumption in a Stirred Tank Bioreactor Using Single and Dual Impeller Configurations

    OpenAIRE

    ALI KARIMI; FARIDEH GOLBABAEI; MOHAMMADREZA MEHRNIA; KAZEM MOHAMMAD; MASOUD NEGHAB; AHMAD NIKPEY; MOHAMMADREZA POURMAND

    2015-01-01

     A laboratory stirred tank bioreactor with six single and dual-impeller configurations was tested to obtain the optimum operating conditions for future biological processes. Six impeller combinations consisting of three basic impeller types, namely Rushton turbine (RT), pitched 4blade (P4B) and pitched 2blade (P2B) downward flow were investigated in 1.77 L bioreactor working volume. Power consumption and gas hold-up measurements were taken over a range of 100-1000 rpm of stirring speed and 1-...

  16. Adult Cancers in Adolescents and Young Adults.

    Science.gov (United States)

    Laurence, Valérie; Marples, Maria; Stark, Daniel P

    2016-01-01

    The pattern of cancer seen in young people changes with increasing age, transitioning from childhood- to adult-type cancer in adolescence and the third decade. The risk factors, presentation and biology of cancer in young adults differ from those in the older adult population. Factors of particular significance in adolescents and young adults (AYAs) include genetic predisposition to adult-type cancer, diagnostic uncertainty, long-term morbidity and considerations of fertility. New systemic therapies are being introduced that can prolong life and even increase the chance of cure, but the impact on AYAs is uncertain, as these patients are often under-represented in clinical trials. Here, we discuss the management of AYAs with 3 of the most common cancers affecting adults, when they emerge in the AYA populations, and therefore are currently met by medical oncologists - breast cancer, colorectal cancer and melanoma. PMID:27595357

  17. Intraspecific and interspecific pre-adult competition on the neotropical region colonizer Zaprionus indianus (Diptera: Drosophilidae under laboratory conditions Competição pré-adulta intra e interespecífica, em Zaprionus indianus (Diptera: Drosophilidae, espécie colonizadora da região neotropical, sob condições laboratoriais

    Directory of Open Access Journals (Sweden)

    Luís Gustavo da Conceição Galego

    2005-01-01

    Full Text Available This study analyzes the pre-adult interactions of Zaprionus indianus, a recently-introduced species in Brazil, with two others Drosophilidae under laboratory conditions. The effects of larval residues on the viability and on the developmental time of Z. indianus, Drosophila simulans and D. sturtevanti were used to evaluate pre-adult competitive interactions, conditioning the culture medium with larval residues. Pre-adult interactions between Z. indianus, D. sturtevanti and D. simulans may affect their relative abundance over time, since the viability of Z. indianus was negatively affected by residues of D. sturtevanti, and its residues reduced the viability of D. simulans and the developmental time of both D. simulans and D. sturtevanti.Este estudo é uma análise das interações pré-adultas, sob condições laboratoriais, da mosca-do-figo Zaprionus indianus, espécie recentemente introduzida no Brasil, com dois outros drosofilídeos. A interferência de meio de cultura, acrescido de resíduos larvais, sobre a viabilidade e o tempo de desenvolvimento de Z. indianus, Drosophila simulans e D. sturtevanti foi utilizada para avaliar as interações competitivas pré-adultas. As interações pré-adultas entre Z. indianus, D. sturtevanti e D. simulans podem afetar sua abundância relativa ao longo do tempo, pois a viabilidade de Z. indianus foi negativamente afetada por resíduos de D. sturtevanti; os resíduos da mosca-do-figo reduziram a viabilidade de D. simulans e o tempo de desenvolvimento tanto de D. simulans como de D. sturtevanti.

  18. European consensus statement on diagnosis and treatment of adult ADHD: the European Network adult ADHD

    LENUS (Irish Health Repository)

    Kooij, Sandra JJ

    2010-09-03

    Abstract Background Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe. Methods The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated. Results Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated? Conclusions ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group.

  19. Speeding Up Sigmatropic Shifts-To Halve or to Hold.

    Science.gov (United States)

    Tantillo, Dean J

    2016-04-19

    Catalysis is common. Rational catalyst design, however, is at the frontier of chemical science. Although the histories of physical organic and synthetic organic chemistry boast key chapters involving [3s,3s] sigmatropic shifts, catalysis of these reactions is much less common than catalysis of ostensibly more complex processes. The comparative dearth of catalysts for sigmatropic shifts is perhaps a result of the perception that transition state structures for these reactions, like their reactants, are nonpolar and therefore not amenable to selective stabilization and its associated barrier lowering. However, as demonstrated in this Account, transition state structures for [3s,3s] sigmatropic shifts can in fact have charge distributions that differ significantly from those of reactants, even for hydrocarbon substrates, allowing for barriers to be decreased and rates increased. In some cases, differences in charge distribution result from the inclusion of heteroatoms at specific positions in reactants, but in other cases differences are actually induced by catalysts. Perhaps surprisingly, strategies for complexation of transition state structures that remain nonpolar are also possible. In general, the strategies for catalysis employed can be characterized as involving either mechanistic intervention, where a catalyst induces a change from the concerted mechanism expected for a [3s,3s] sigmatropic shift to a multistep process (cutting the transformation into halves or smaller pieces) whose overall barrier is decreased relative to the concerted process, or transition state complexation, where a catalyst simply binds (holds) more tightly to the transition state structure for a [3s,3s] sigmatropic shift than to the reactant, leading to a lower barrier in the presence of the catalyst. Both of these strategies can be considered to be biomimetic in that enzymes frequently induce multistep processes and utilize selective transition state stabilization for the steps involved

  20. Lexicographic probability, conditional probability, and nonstandard probability

    OpenAIRE

    Halpern, Joseph Y.

    2003-01-01

    The relationship between Popper spaces (conditional probability spaces that satisfy some regularity conditions), lexicographic probability systems (LPS's), and nonstandard probability spaces (NPS's) is considered. If countable additivity is assumed, Popper spaces and a subclass of LPS's are equivalent; without the assumption of countable additivity, the equivalence no longer holds. If the state space is finite, LPS's are equivalent to NPS's. However, if the state space is infinite, NPS's are ...

  1. 20 CFR 703.103 - Stock companies holding Treasury certificates of authority.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Stock companies holding Treasury certificates... REGULATIONS Authorization of Insurance Carriers § 703.103 Stock companies holding Treasury certificates of authority. A stock company furnishing evidence that it is authorized to write workmen's...

  2. 75 FR 10863 - Savings Association Holding Company Report H-(b)11

    Science.gov (United States)

    2010-03-09

    ... Office of Thrift Supervision Savings Association Holding Company Report H-(b)11 AGENCY: Office of Thrift... collection. Title of Proposal: Savings Association Holding Company Report H- (b)11. OMB Number: 1550-0060. Form Numbers: OTS Form H-(b)11. Regulation requirement: 12 CFR part 584.1. Description: Section...

  3. 78 FR 73915 - Community Alliance, Inc., Defi Global, Inc., Easy Energy, Inc., Industry Concept Holdings, Inc...

    Science.gov (United States)

    2013-12-09

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Community Alliance, Inc., Defi Global, Inc., Easy Energy, Inc., Industry Concept Holdings, Inc... information concerning the securities of Industry Concept Holdings, Inc. because it has not filed any...

  4. 46 CFR 32.75-20 - Hold spaces and bulkheads-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Hold spaces and bulkheads-TB/ALL. 32.75-20 Section 32.75-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Hull Requirements for Wood Hull Tank Vessels Constructed Prior to November 10, 1936 § 32.75-20 Hold spaces and...

  5. 77 FR 26585 - Steel Partners Holdings L.P.; Notice of Application

    Science.gov (United States)

    2012-05-04

    ... COMMISSION Steel Partners Holdings L.P.; Notice of Application April 27, 2012. AGENCY: Securities and... Investment Company Act of 1940 (``Act''). Summary of Application: Steel Partners Holdings L.P. (``SPH... its acquisition of WebBank in 1998 until July 14, 2009. 2. Prior to December 2008, Steel Partners...

  6. 12 CFR 1500.3 - What are the holding periods permitted for merchant banking investments?

    Science.gov (United States)

    2010-01-01

    ... CFR 225 appendix A) to merchant banking investments held by that financial holding company; and (B) In... 12 Banks and Banking 7 2010-01-01 2010-01-01 false What are the holding periods permitted for merchant banking investments? 1500.3 Section 1500.3 Banks and Banking DEPARTMENT OF THE TREASURY...

  7. Heterogeneity among methicillin-resistant Staphylococcus aureus from Italian pig finishing holdings

    DEFF Research Database (Denmark)

    Battisti, A.; Franco, A.; Merialdi, G.;

    2010-01-01

    A survey for methicillin-resistant Staphylococcus aureus (MRSA) in finishing pig holdings was carried out in Italy in 2008. MRSA isolates were characterised by spa-. SCCmec- and antimicrobial susceptibility typing. A prevalence of 38% (45/118, 95% CI 29.4-46.9%) positive holdings was observed...

  8. 46 CFR 154.305 - Segregation of hold spaces from the sea.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Segregation of hold spaces from the sea. 154.305 Section... Equipment Ship Arrangements § 154.305 Segregation of hold spaces from the sea. In vessels having cargo... sea by: (a) A double bottom if the cargo tanks meet this part for design temperatures colder than...

  9. 12 CFR 225.101 - Bank holding company's subsidiary banks owning shares of nonbanking companies.

    Science.gov (United States)

    2010-01-01

    ...) apply to the aggregate amount of stock held in a particular organization by the bank holding company... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company's subsidiary banks owning... company's subsidiary banks owning shares of nonbanking companies. (a) The Board's opinion has...

  10. 26 CFR 1.954-2T - Foreign personal holding company income (temporary).

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Foreign personal holding company income... holding company income (temporary). (a) through (c)(2)(i) For further guidance see, § 1.954-2(a) through (c)(2)(i). (ii) Substantiality of foreign organization. For purposes of paragraph (c)(1)(iv) of...

  11. 12 CFR 225.102 - Bank holding company indirectly owning nonbanking company through subsidiaries.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Bank holding company indirectly owning nonbanking company through subsidiaries. 225.102 Section 225.102 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN...

  12. The Ins and Outs of Breath Holding: Simple Demonstrations of Complex Respiratory Physiology

    Science.gov (United States)

    Skow, Rachel J.; Day, Trevor A.; Fuller, Jonathan E.; Bruce, Christina D.; Steinback, Craig D.

    2015-01-01

    The physiology of breath holding is complex, and voluntary breath-hold duration is affected by many factors, including practice, psychology, respiratory chemoreflexes, and lung stretch. In this activity, we outline a number of simple laboratory activities or classroom demonstrations that illustrate the complexity of the integrative physiology…

  13. Methodology of correcting strategy for the formation of a holding intellectual capital

    Directory of Open Access Journals (Sweden)

    Liliya R. Iksanova

    2014-01-01

    Full Text Available Objective to rationalize the strategy and management of the holding intellectual capital. Methods in this work we have applied the methods of analysis synthesis comparison induction and deduction. Results a phased methodology of correcting strategy for the intellectual capital formation in a holding is developed. Basing on the analysis of economicstatistical functions the impact of the intellectual capital reproduction costs on innovative activity is estimated. For each of the received options recommendations are given for the rationalisation strategies and systems of intellectual capital management. the developed technique is tested on the specific example of a holding. Scientific novelty a method is proposed to correct the strategy for the intellectual capital formation in a holding. The basis of the method is the analysis of the influence functions of the intellectual capital reproduction cost on innovative activity where the innovative products works services share in the total structure of the enterprise production should be used as one of the most common indicators of innovation activity of a holding. Practical value an opportunity to detect the most and the least effective holding enterprises from the point of view of intellectual capital and to develop a system of measures for the specification of the provisions of the new development strategy of the intellectual capital of a holding thereby contributing to the development of competitive advantages of a holding.

  14. 75 FR 15709 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Science.gov (United States)

    2010-03-30

    ... regulations to become a bank holding company and/or to acquire the assets or the ownership of, control of, or...Financial, Inc., Pigeon Forge, Tennessee; to become a bank holding company by acquiring 100 percent of the outstanding shares of SmartBank, Pigeon Forge, Tennessee. Board of Governors of the Federal Reserve...

  15. 76 FR 27669 - Automotive Components Holdings, LLC, a Subsidiary of Ford Motor Company, Saline Plant Division...

    Science.gov (United States)

    2011-05-12

    ..., 2010 (75 FR 65514). The workers are engaged in employment related to the production of interior... Employment and Training Administration Automotive Components Holdings, LLC, a Subsidiary of Ford Motor... Application for Reconsideration for the workers and former workers of Automotive Components Holdings, LLC,...

  16. Poultry water holding capacity measurements using infrared spectroscopies correlated to traditional methods

    Science.gov (United States)

    Water holding capacity (WHC) in chicken meat is directly correlated with the quality of the meat. Lower water holding capacity is linked with decreased sensory qualities and therefore lower consumer satisfaction. Additionally, measurement of WHC is subject to wide variations which can depend on many...

  17. 77 FR 76160 - New Generation Biofuels Holdings, Inc.; Order of Suspension of Trading

    Science.gov (United States)

    2012-12-26

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION New Generation Biofuels Holdings, Inc.; Order of Suspension of Trading December 21, 2012. It... concerning the securities of New Generation Biofuels Holdings, Inc. because it has not filed any...

  18. Simulation of the high temperature intergranular strain hardening in fatigue of materials with hold time

    International Nuclear Information System (INIS)

    This paper aims to simulate the behavior of some alloys in high temperature fatigue-relaxation (creep), for a long hold time (one month for each cycle) when laboratory experiments are difficult to realize. The first part presents an estimation of the internal intergranular stresses. The second part deals with the recovery occurring during the hold time. (A.L.B.)

  19. Improving Work Participation of Young Adults with Physical Disabilities

    OpenAIRE

    Verhoef, Joan

    2015-01-01

    markdownabstract__Abstract__ This thesis addresses the work participation of young adults with physical disabilities caused by a chronic condition. With increasing numbers of young people with a chronic physical condition living into adulthood, knowledge about the development of work participation in these young adults and the support they need to achieve suitable employment is needed. Interventions to improve the work participation of young adults with physical disabilities were lacking. The...

  20. Impact of collection container material and holding times on sample integrity for mercury and methylmercury in water

    Energy Technology Data Exchange (ETDEWEB)

    Riscassi, Ami L [ORNL; Miller, Carrie L [ORNL; Brooks, Scott C [ORNL

    2014-01-01

    Mercury (Hg) and methylmercury (MeHg) concentrations in streamwater can vary on short timescales (hourly or less) during storm flow and on a diel cycle; the frequency and timing of sampling required to accurately characterize these dynamics may be difficult to accomplish manually. Automated sampling can assist in sample collection; however use has been limited for Hg and MeHg analysis due to stability concerns of trace concentrations during extended storage times. We examined the viability of using automated samplers with disposable low-density polyethylene (LDPE) sample bags to collect industrially contaminated streamwater for unfiltered and filtered Hg and MeHg analysis. Specifically we investigated the effect of holding times ranging from hours to days on streamwater collected during baseflow and storm flow. Unfiltered and filtered Hg and MeHg concentrations decreased with increases in time prior to sample processing; holding times of 24 hours or less resulted in concentration changes (mean 11 7% different) similar to variability in duplicates collected manually during analogous field conditions (mean 7 10% different). Comparisons of samples collected with manual and automated techniques throughout a year for a wide range of stream conditions were also found to be similar to differences observed between duplicate grab samples. These results demonstrate automated sampling into LDPE bags with holding times of 24 hours or less can be effectively used to collect streamwater for Hg and MeHg analysis, and encourage the testing of these materials and methods for implementation in other aqueous systems where high-frequency sampling is warranted.