WorldWideScience

Sample records for administration lewis research

  1. Lewy Body Dementia Research

    Science.gov (United States)

    ... a new treatment for hallucinations in Parkinson’s disease. Symptoms Differ in Alzheimer's when Lewy Bodies are Present June, 2015 - Lewy ... distinguish the underlying cause or causes of dementia symptoms. The diagnostic ... Alzheimer’s disease pathology alone versus those who have both ...

  2. Lewis' Educational and Research Collaborative Internship Program

    Science.gov (United States)

    Heyward, Ann; Gott, Susan (Technical Monitor)

    2004-01-01

    The Lewis Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships in addition to summer and winter extensions if funding is available and/or is requested by mentor (no less than 1 week no more than 4 weeks) for undergraduate/graduate students and secondary school teachers. Students who meet the travel reimbursement criteria receive up to $500 for travel expenses. Approximately 178 interns are selected to participate in this program each year and begin arriving the fourth week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, and lectures. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds. The purpose of this report is to document the program accomplishments for 2004.

  3. Gear and Transmission Research at NASA Lewis Research Center

    Science.gov (United States)

    Townsend, Dennis P.

    1997-01-01

    This paper is a review of some of the research work of the NASA Lewis Research Center Mechanical Components Branch. It includes a brief review of the NASA Lewis Research Center and the Mechanical Components Branch. The research topics discussed are crack propagation of gear teeth, gear noise of spiral bevel and other gears, design optimization methods, methods we have investigated for transmission diagnostics, the analytical and experimental study of gear thermal conditions, the analytical and experimental study of split torque systems, the evaluation of several new advanced gear steels and transmission lubricants and the evaluation of various aircraft transmissions. The area of research needs for gearing and transmissions is also discussed.

  4. Superconducting Microwave Electronics at Lewis Research Center

    Science.gov (United States)

    Warner, Joseph D.; Bhasin, Kul B.; Leonard, Regis F.

    1991-01-01

    Over the last three years, NASA Lewis Research Center has investigated the application of newly discovered high temperature superconductors to microwave electronics. Using thin films of YBa2Cu3O7-delta and Tl2Ca2Ba2Cu3Ox deposited on a variety of substrates, including strontium titanate, lanthanum gallate, lanthanum aluminate and magnesium oxide, a number of microwave circuits have been fabricated and evaluated. These include a cavity resonator at 60 GHz, microstrip resonators at 35 GHz, a superconducting antenna array at 35 GHz, a dielectric resonator at 9 GHz, and a microstrip filter at 5 GHz. Performance of some of these circuits as well as suggestions for other applications are reported.

  5. Lewis' Educational and Research Collaborative Intership Program Grant Closeout Report

    Science.gov (United States)

    2003-01-01

    The Lewis' Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships and 10 or 12-week fellowships for undergraduate/graduate students and secondary school teachers. Approximately 130 interns are selected to participate in this program each year and begin arriving the second week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, lectures and short courses. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds.

  6. Chemical Inventory Management at NASA Lewis Research Center

    Science.gov (United States)

    Kraft, Shirley S.; Homan, Joseph R.; Bajorek, Michael J.; Dominguez, Manuel B.; Smith, Vanessa L.

    1997-01-01

    The Chemical Management System (CMS) is a client/server application developed with Power Builder and Sybase for the Lewis Research Center (LeRC). Power Builder is a client-server application development tool, Sybase is a Relational Database Management System. The entire LeRC community can access the CMS from any desktop environment. The multiple functions and benefits of the CMS are addressed.

  7. Telecommuting (Work-At-Home) at NASA Lewis Research Center

    Science.gov (United States)

    Srinidhi, Saragur M.

    1994-01-01

    This report presents a study in evaluating the viability of providing a work-at-home (telecommuting) program for Lewis Research Center's corporate employees using Integrated Services Digital Network (ISDN). Case studies have been presented for a range of applications from casual data access to interactive access. The network performance of telemedia applications were studied against future requirements for such level of remote connectivity. Many of the popular ISDN devices were characterized for network and service functionality. A set of recommendations to develop a telecommuting policy have been proposed.

  8. Solar photovoltaics: Stand alone applications. [NASA Lewis Research Center research and development

    Science.gov (United States)

    Deyo, J. N.

    1980-01-01

    The Lewis Research Center involvement in space photovoltaic research and development and in using photovoltaics for terrestrial applications is described with emphasis on applications in which the normal source of power may be a diesel generator, batteries, or other types of power not connected to a utility grid. Once an application is processed, technology is developed and demonstrated with a user who participates in the cost and furnishes the site. Projects completed related to instruments, communication, refrigeration, and highways, are described as well as warning systems, weather stations, fire lookouts, and village power systems. A commercially available photovoltaic powered electric fence charger is the result of Lewis research and development.

  9. An Engineering Approach to Management of Occupational and Community Noise Exposure at NASA Lewis Research Center

    Science.gov (United States)

    Cooper, Beth A.

    1997-01-01

    Workplace and environmental noise issues at NASA Lewis Research Center are effectively managed via a three-part program that addresses hearing conservation, community noise control, and noise control engineering. The Lewis Research Center Noise Exposure Management Program seeks to limit employee noise exposure and maintain community acceptance for critical research while actively pursuing engineered controls for noise generated by more than 100 separate research facilities and the associated services required for their operation.

  10. A Comprehensive Approach to Management of Workplace and Environmental Noise at NASA Lewis Research Center

    Science.gov (United States)

    Cooper, Beth A.

    1995-01-01

    NASA Lewis Research Center is home to more than 100 experimental research testing facilities and laboratories, including large wind tunnels and engine test cells, which in combination create a varied and complex noise environment. Much of the equipment was manufactured prior to the enactment of legislation limiting product noise emissions or occupational noise exposure. Routine facility maintenance and associated construction also contributes to a noise exposure management responsibility which is equal in magnitude and scope to that of several small industrial companies. The Noise Program, centrally managed within the Office of Environmental Programs at LRC, maintains overall responsibility for hearing conservation, community noise control, and acoustical and noise control engineering. Centralized management of the LRC Noise Program facilitates the timely development and implementation of engineered noise control solutions for problems identified via either the Hearing Conservation of Community Noise Program. The key element of the Lewis Research Center Noise Program, Acoustical and Noise Control Engineering Services, is focused on developing solutions that permanently reduce employee and community noise exposure and maximize research productivity by reducing or eliminating administrative and operational controls and by improving the safety and comfort of the work environment. The Hearing Conservation Program provides noise exposure assessment, medical monitoring, and training for civil servant and contractor employees. The Community Noise Program aims to maintain the support of LRC's neighboring communities while enabling necessary research operations to accomplish their programmatic goals. Noise control engineering capability resides within the Noise Program. The noise control engineering, based on specific exposure limits, is a fundamental consideration throughout the design phase of new test facilities, labs, and office buildings. In summary, the Noise Program

  11. Anatomy of an organizational change effort at the Lewis Research Center

    Science.gov (United States)

    Hawker, James R.; Dali, Richard S.

    1988-01-01

    By 1979, after a long decline following the end of the Apollo program, the Lewis Research Center found its very existence endangered because it was not doing the kind of research that could attract funding at the time. New management under Andrew J. Stofan applied a program of strategic planning, participative management, and consensus decision making. A corporate-cultural change was effected which enabled Lewis to commit itself to four fundable research and development projects. Morale-building and training programs which were essential to this change are described.

  12. Historical perspectives: The role of the NASA Lewis Research Center in the national space nuclear power programs

    Science.gov (United States)

    Bloomfield, H. S.; Sovie, R. J.

    1991-01-01

    The history of the NASA Lewis Research Center's role in space nuclear power programs is reviewed. Lewis has provided leadership in research, development, and the advancement of space power and propulsion systems. Lewis' pioneering efforts in nuclear reactor technology, shielding, high temperature materials, fluid dynamics, heat transfer, mechanical and direct energy conversion, high-energy propellants, electric propulsion and high performance rocket fuels and nozzles have led to significant technical and management roles in many national space nuclear power and propulsion programs.

  13. Historical perspectives - The role of the NASA Lewis Research Center in the national space nuclear power programs

    Science.gov (United States)

    Bloomfield, H. S.; Sovie, R. J.

    1991-01-01

    The history of the NASA Lewis Research Center's role in space nuclear power programs is reviewed. Lewis has provided leadership in research, development, and the advancement of space power and propulsion systems. Lewis' pioneering efforts in nuclear reactor technology, shielding, high temperature materials, fluid dynamics, heat transfer, mechanical and direct energy conversion, high-energy propellants, electric propulsion and high performance rocket fuels and nozzles have led to significant technical and management roles in many natural space nuclear power and propulsion programs.

  14. ADMINISTRATION, TEACHING AND RESEARCH PHILOSOPHIES

    OpenAIRE

    FLORENTIN SMARANDACHE

    2015-01-01

    A simple, direct, fast point of view regarding my perception of Administration Philosophy, Teaching Philosophy, Research Philosophy (including My Own Research), and What I Can Bring to This Institution

  15. NASA Lewis Research Center low-gravity fluid management technology program

    Science.gov (United States)

    Aydelott, J. C.; Carney, M. J.; Hochstein, J. I.

    1985-01-01

    A history of the Lewis Research Center in space fluid management technology program is presented. Current programs which include numerical modeling of fluid systems, heat exchanger/radiator concept studies, and the design of the Cryogenic Fluid Management Facility are discussed. Recent analytical and experimental activities performed to support the Shuttle/Centaur development activity are highlighted.

  16. Gear noise, vibration, and diagnostic studies at NASA Lewis Research Center

    Science.gov (United States)

    Zakrajsek, J. J.; Oswald, F. B.; Townsend, D. P.; Coy, J. J.

    1990-01-01

    The NASA Lewis Research Center and the U.S. Army Aviation Systems Command are involved in a joint research program to advance the technology of rotorcraft transmissions. This program consists of analytical as well as experimental efforts to achieve the overall goals of reducing weight, noise, and vibration, while increasing life and reliability. Recent analytical activities are highlighted in the areas of gear noise, vibration, and diagnostics performed in-house and through NASA and U.S. Army sponsored grants and contracts. These activities include studies of gear tooth profiles to reduce transmission error and vibration as well as gear housing and rotordynamic modeling to reduce structural vibration and transmission and noise radiation, and basic research into current gear failure diagnostic methodologies. Results of these activities are presented along with an overview of near-term research plans in the gear noise, vibration, and diagnostics area.

  17. Amphetamine self-administration and dopamine function: assessment of gene × environment interactions in Lewis and Fischer 344 rats.

    Science.gov (United States)

    Meyer, Andrew C; Bardo, Michael T

    2015-07-01

    Previous research suggests both genetic and environmental influences on substance abuse vulnerability. The current work sought to investigate the interaction of genes and environment on the acquisition of amphetamine self-administration as well as amphetamine-stimulated dopamine (DA) release in nucleus accumbens shell using in vivo microdialysis. Inbred Lewis (LEW) and Fischer (F344) rat strains were raised in either an enriched condition (EC), social condition (SC), or isolated condition (IC). Acquisition of amphetamine self-administration (0.1 mg/kg/infusion) was determined across an incrementing daily fixed ratio (FR) schedule. In a separate cohort of rats, extracellular DA and the metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) were measured in the nucleus accumbens shell following an acute amphetamine injection (1 mg/kg). "Addiction-prone" LEW rats had greater acquisition of amphetamine self-administration on a FR1 schedule compared to "addiction-resistant" F344 rats when raised in the SC environment. These genetic differences were negated in both the EC and IC environments, with enrichment buffering against self-administration and isolation enhancing self-administration in both strains. On a FR5 schedule, the isolation-induced increase in amphetamine self-administration was greater in F344 than LEW rats. While no group differences were obtained in extracellular DA, gene × environment differences were obtained in extracellular levels of the metabolite DOPAC. In IC rats only, LEW rats showed attenuation in the amphetamine-induced decrease in DOPAC compared to F344 rats. IC LEW rats also had an attenuated DOPAC response to amphetamine compared to EC LEW rats. The current results demonstrate gene × environment interactions in amphetamine self-administration and amphetamine-induced changes in extracellular DOPAC in nucleus accumbens (NAc) shell. However, the behavioral and neurochemical differences were not related directly, indicating that

  18. A Review of Recent Aeroelastic Analysis Methods for Propulsion at NASA Lewis Research Center

    Science.gov (United States)

    Reddy, T. S. R.; Bakhle, Milind A.; Srivastava, R.; Mehmed, Oral; Stefko, George L.

    1993-01-01

    This report reviews aeroelastic analyses for propulsion components (propfans, compressors and turbines) being developed and used at NASA LeRC. These aeroelastic analyses include both structural and aerodynamic models. The structural models include a typical section, a beam (with and without disk flexibility), and a finite-element blade model (with plate bending elements). The aerodynamic models are based on the solution of equations ranging from the two-dimensional linear potential equation to the three-dimensional Euler equations for multibladed configurations. Typical calculated results are presented for each aeroelastic model. Suggestions for further research are made. Many of the currently available aeroelastic models and analysis methods are being incorporated in a unified computer program, APPLE (Aeroelasticity Program for Propulsion at LEwis).

  19. Space applications of superconducting microwave electronics at NASA Lewis Research Center

    Science.gov (United States)

    Leonard, R. F.; Bhasin, K. B.; Romanofsky, R. R.; Cubbage, C. D.; Chorey, C. Z.

    1993-01-01

    Since the discovery of high temperature superconductivity in 1987, NASA Lewis Research Center has been involved in efforts to demonstrate its advantages for applications involving microwave electronics in space, especially space communications. The program included thin film fabrication by means of laser ablation. Specific circuitry which was investigated includes microstrip ring resonators at 32 GHz, phase shifters which utilize a superconducting, optically activated switch, an 8x8 32 GHz superconducting microstrip antenna array, and an HTS-ring-resonator stabilized oscillator at 8 GHz. The latter two components are candidates for use in space experiments which are described in other papers. Experimental data on most of the circuits are presented as well as, in some cases, a comparison of their performance with an identical circuit utilizing gold or copper metallization.

  20. Research Contributions towards Guidelines for Land Administration

    DEFF Research Database (Denmark)

    Stubkjær, Erik

    . Recently, the issue of the core of the cadastral system was addressed. The presentation will summarise the research outcome, and relate it to development needs in European land administration, as illustrated by the Land Administration Guidelines. Comments on long-term capacity building and on terminology...

  1. Research Contributions towards Guidelines for Land Administration

    DEFF Research Database (Denmark)

    Stubkjær, Erik

    . Recently, the issue of the core of the cadastral system was addressed. The presentation will summarise the research outcome, and relate it to development needs in European land administration, as illustrated by theLand Administration Guidelines. Comments on long-term capacity building and on terminology...

  2. Database Support for Research in Public Administration

    Science.gov (United States)

    Tucker, James Cory

    2005-01-01

    This study examines the extent to which databases support student and faculty research in the area of public administration. A list of journals in public administration, public policy, political science, public budgeting and finance, and other related areas was compared to the journal content list of six business databases. These databases…

  3. CLARA: an integrated clinical research administration system.

    Science.gov (United States)

    Bian, Jiang; Xie, Mengjun; Hogan, William; Hutchins, Laura; Topaloglu, Umit; Lane, Cheryl; Holland, Jennifer; Wells, Thomas

    2014-10-01

    Administration of human subject research is complex, involving not only the institutional review board but also many other regulatory and compliance entities within a research enterprise. Its efficiency has a direct and substantial impact on the conduct and management of clinical research. In this paper, we report on the Clinical Research Administration (CLARA) platform developed at the University of Arkansas for Medical Sciences. CLARA is a comprehensive web-based system that can streamline research administrative tasks such as submissions, reviews, and approval processes for both investigators and different review committees on a single integrated platform. CLARA not only helps investigators to meet regulatory requirements but also provides tools for managing other clinical research activities including budgeting, contracting, and participant schedule planning.

  4. [Dementia and Lewy bodies].

    Science.gov (United States)

    Kaufer, D

    Consensus diagnostic criteria for dementia with Lewy bodies (DLB) proposed in 1996 have provided a useful foundation for research in the field. As a clinicopathologically defined entity, DLB has overlapping features of both Alzheimer s disease (AD) and Parkinson's disease (PD). Consensus criteria for DLB distinguish it from PD dementia by the earlier appearance of motor signs in the latter. Studies evaluating the standardized clinical diagnostic criteria for DLB have generally found them to be highly predictive of Lewy body pathology. However, many cases with Lewy body pathology and concomitant pathological features of AD elude clinical detection. Emerging data suggests that AD pathological features mask the clinical expression of concomitant Lewy body pathology, and that DLB and PD dementia may be more similar than distinct.

  5. Pharmacy Administration and Clinical Practice Research Agenda.

    Science.gov (United States)

    Hepler, Charles D.

    1987-01-01

    Research needs for pharmacy administration and clinical pharmacy include study of the relationship of pharmacists and society, management methods for providing health care services, pharmacist training and socialization, competence evaluation, formative and summative research on drug use control, and organizational decision making. (MSE)

  6. Advancing Administrative Supports for Research Development

    Science.gov (United States)

    Briar-Lawson, Katharine; Korr, Wynne; White, Barbara; Vroom, Phyllis; Zabora, James; Middleton, Jane; Shank, Barbara; Schatz, Mona

    2008-01-01

    Research administrative supports must parallel and reinforce faculty initiatives in research grant procurement. This article features several types of developments that draw on presentations at the National Association of Deans and Directors of Schools of Social Work meetings. Key changes in social work programs are addressed, including the…

  7. Pharmacy Administration and Clinical Practice Research Agenda.

    Science.gov (United States)

    Hepler, Charles D.

    1987-01-01

    Research needs for pharmacy administration and clinical pharmacy include study of the relationship of pharmacists and society, management methods for providing health care services, pharmacist training and socialization, competence evaluation, formative and summative research on drug use control, and organizational decision making. (MSE)

  8. Splitter-bladed centrifugal compressor impeller designed for automotive gas turbine application. [at the Lewis Research Center

    Science.gov (United States)

    Pampreen, R. C.

    1977-01-01

    Mechanical design and fabrication of two splitter-bladed centrifugal compressor impellers were completed for rig testing at NASA Lewis Research Center. These impellers were designed for automotive gas turbine application. The mechanical design was based on NASA specifications for blade-shape and flowpath configurations. The contractor made engineering drawings and performed calculations for mass and center-of-gravity, for stress and vibration analyses, and for shaft critical speed analysis. One impeller was machined to print; the other had a blade height and exit radius of 2.54 mm larger than print dimensions.

  9. LERC-SLAM - THE NASA LEWIS RESEARCH CENTER SATELLITE LINK ATTENUATION MODEL PROGRAM (IBM PC VERSION)

    Science.gov (United States)

    Manning, R. M.

    1994-01-01

    The frequency and intensity of rain attenuation affecting the communication between a satellite and an earth terminal is an important consideration in planning satellite links. The NASA Lewis Research Center Satellite Link Attenuation Model Program (LeRC-SLAM) provides a static and dynamic statistical assessment of the impact of rain attenuation on a communications link established between an earth terminal and a geosynchronous satellite. The program is designed for use in the specification, design and assessment of satellite links for any terminal location in the continental United States. The basis for LeRC-SLAM is the ACTS Rain Attenuation Prediction Model, which uses a log-normal cumulative probability distribution to describe the random process of rain attenuation on satellite links. The derivation of the statistics for the rainrate process at the specified terminal location relies on long term rainfall records compiled by the U.S. Weather Service during time periods of up to 55 years in length. The theory of extreme value statistics is also utilized. The user provides 1) the longitudinal position of the satellite in geosynchronous orbit, 2) the geographical position of the earth terminal in terms of latitude and longitude, 3) the height above sea level of the terminal site, 4) the yearly average rainfall at the terminal site, and 5) the operating frequency of the communications link (within 1 to 1000 GHz, inclusive). Based on the yearly average rainfall at the terminal location, LeRC-SLAM calculates the relevant rain statistics for the site using an internal data base. The program then generates rain attenuation data for the satellite link. This data includes a description of the static (i.e., yearly) attenuation process, an evaluation of the cumulative probability distribution for attenuation effects, and an evaluation of the probability of fades below selected fade depths. In addition, LeRC-SLAM calculates the elevation and azimuth angles of the terminal

  10. LERC-SLAM - THE NASA LEWIS RESEARCH CENTER SATELLITE LINK ATTENUATION MODEL PROGRAM (MACINTOSH VERSION)

    Science.gov (United States)

    Manning, R. M.

    1994-01-01

    The frequency and intensity of rain attenuation affecting the communication between a satellite and an earth terminal is an important consideration in planning satellite links. The NASA Lewis Research Center Satellite Link Attenuation Model Program (LeRC-SLAM) provides a static and dynamic statistical assessment of the impact of rain attenuation on a communications link established between an earth terminal and a geosynchronous satellite. The program is designed for use in the specification, design and assessment of satellite links for any terminal location in the continental United States. The basis for LeRC-SLAM is the ACTS Rain Attenuation Prediction Model, which uses a log-normal cumulative probability distribution to describe the random process of rain attenuation on satellite links. The derivation of the statistics for the rainrate process at the specified terminal location relies on long term rainfall records compiled by the U.S. Weather Service during time periods of up to 55 years in length. The theory of extreme value statistics is also utilized. The user provides 1) the longitudinal position of the satellite in geosynchronous orbit, 2) the geographical position of the earth terminal in terms of latitude and longitude, 3) the height above sea level of the terminal site, 4) the yearly average rainfall at the terminal site, and 5) the operating frequency of the communications link (within 1 to 1000 GHz, inclusive). Based on the yearly average rainfall at the terminal location, LeRC-SLAM calculates the relevant rain statistics for the site using an internal data base. The program then generates rain attenuation data for the satellite link. This data includes a description of the static (i.e., yearly) attenuation process, an evaluation of the cumulative probability distribution for attenuation effects, and an evaluation of the probability of fades below selected fade depths. In addition, LeRC-SLAM calculates the elevation and azimuth angles of the terminal

  11. Status and Development Trend of Administrative Law Research

    Institute of Scientific and Technical Information of China (English)

    Zhipeng Li

    2015-01-01

    Since the new century, the development trend of administrative law and administrative law issues have been a concern for Chinese administrative law scholars, especially in recent years, more and more scholars start to discuss " new administrative law" ,directly or indirectly," New Administrative Law" has become China' s new hot spot for administrative law research. From two aspects, which involve the new direction of the construction of the administrative law system and the new vision of the administrative law, relevant research results on law research were reviewed and commented, and a number of visions were made on the future development of China' s administrative law, which were practically significant.

  12. Lewis icing research tunnel test of the aerodynamic effects of aircraft ground deicing/anti-icing fluids

    Science.gov (United States)

    Runyan, L. James; Zierten, Thomas A.; Hill, Eugene G.; Addy, Harold E., Jr.

    1992-01-01

    A wind tunnel investigation of the effect of aircraft ground deicing/anti-icing fluids on the aerodynamic characteristics of a Boeing 737-200ADV airplane was conducted. The test was carried out in the NASA Lewis Icing Research Tunnel. Fluids tested include a Newtonian deicing fluid, three non-Newtonian anti-icing fluids commercially available during or before 1988, and eight new experimental non-Newtonian fluids developed by four fluid manufacturers. The results show that fluids remain on the wind after liftoff and cause a measurable lift loss and drag increase. These effects are dependent on the high-lift configuration and on the temperature. For a configuration with a high-lift leading-edge device, the fluid effect is largest at the maximum lift condition. The fluid aerodynamic effects are related to the magnitude of the fluid surface roughness, particularly in the first 30 percent chord. The experimental fluids show a significant reduction in aerodynamic effects.

  13. Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF and Matrix Metalloproteinases (MMPs in Lewis Tumor-Bearing Mice

    Directory of Open Access Journals (Sweden)

    Tse-Hung Huang

    2015-04-01

    Full Text Available Fucoidan, a heparin-like sulfated polysaccharide, is rich in brown algae. It has a wide assortment of protective activities against cancer, for example, induction of hepatocellular carcinoma senescence, induction of human breast and colon carcinoma apoptosis, and impediment of lung cancer cells migration and invasion. However, the anti-metastatic mechanism that fucoidan exploits remains elusive. In this report, we explored the effects of fucoidan on cachectic symptoms, tumor development, lung carcinoma cell spreading and proliferation, as well as expression of metastasis-associated proteins in the Lewis lung carcinoma (LLC cells-inoculated mice model. We discovered that administration of fucoidan has prophylactic effects on mitigation of cachectic body weight loss and improvement of lung masses in tumor-inoculated mice. These desired effects are attributed to inhibition of LLC spreading and proliferation in lung tissues. Fucoidan also down-regulates expression of matrix metalloproteinases (MMPs, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB and vascular endothelial growth factor (VEGF. Moreover, the tumor-bearing mice supplemented with fucoidan indeed benefit from an ensemble of the chemo-phylacticity. The fact is that fucoidan significantly decreases viability, migration, invasion, and MMPs activities of LLC cells. In summary, fucoidan is suitable to act as a chemo-preventative agent for minimizing cachectic symptoms as well as inhibiting lung carcinoma metastasis through down-regulating metastatic factors VEGF and MMPs.

  14. Prophylactic administration of fucoidan represses cancer metastasis by inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in Lewis tumor-bearing mice.

    Science.gov (United States)

    Huang, Tse-Hung; Chiu, Yi-Han; Chan, Yi-Lin; Chiu, Ya-Huang; Wang, Hang; Huang, Kuo-Chin; Li, Tsung-Lin; Hsu, Kuang-Hung; Wu, Chang-Jer

    2015-04-03

    Fucoidan, a heparin-like sulfated polysaccharide, is rich in brown algae. It has a wide assortment of protective activities against cancer, for example, induction of hepatocellular carcinoma senescence, induction of human breast and colon carcinoma apoptosis, and impediment of lung cancer cells migration and invasion. However, the anti-metastatic mechanism that fucoidan exploits remains elusive. In this report, we explored the effects of fucoidan on cachectic symptoms, tumor development, lung carcinoma cell spreading and proliferation, as well as expression of metastasis-associated proteins in the Lewis lung carcinoma (LLC) cells-inoculated mice model. We discovered that administration of fucoidan has prophylactic effects on mitigation of cachectic body weight loss and improvement of lung masses in tumor-inoculated mice. These desired effects are attributed to inhibition of LLC spreading and proliferation in lung tissues. Fucoidan also down-regulates expression of matrix metalloproteinases (MMPs), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and vascular endothelial growth factor (VEGF). Moreover, the tumor-bearing mice supplemented with fucoidan indeed benefit from an ensemble of the chemo-phylacticity. The fact is that fucoidan significantly decreases viability, migration, invasion, and MMPs activities of LLC cells. In summary, fucoidan is suitable to act as a chemo-preventative agent for minimizing cachectic symptoms as well as inhibiting lung carcinoma metastasis through down-regulating metastatic factors VEGF and MMPs.

  15. Scientific Self-Regulation: A Brief Primer for Research Administrators

    Science.gov (United States)

    Atkinson, Timothy N.

    2005-01-01

    The National Academies of Science recently recommended a battery of guidelines for Academe to create an "environment" conducive to the responsible conduct of research. These guidelines affect the research administration field as a whole, as research administrators will be expected to assist in these changes. Research administrators,…

  16. Lewy Body Disease

    Science.gov (United States)

    Lewy body disease is one of the most common causes of dementia in the elderly. Dementia is the loss ... enough to affect normal activities and relationships. Lewy body disease happens when abnormal structures, called Lewy bodies, ...

  17. Heat transfer results and operational characteristics of the NASA Lewis Research Center hot section cascade test facility

    Science.gov (United States)

    Gladden, H. J.; Yeh, F. C.; Fronek, D. L.

    1985-01-01

    The NASA Lewis Research Center gas turbine hot section test facility has been developed to provide a real-engine environment with well known boundary conditions for the aerothermal performance evaluation/verification of computer design codes. The initial aerothermal research data obtained are presented and the operational characteristics of the facility are discussed. This facility is capable of testing at temperatures and pressures up to 1600 K and 18 atm which corresponds to a vane exit Reynolds number range of 0.5 x 1 million to 2.5 x 1 million based on vane chord. The component cooling air temperature can be independently modulated between 330 and 700 K providing gas-to-coolant temperature ratios similar to current engine application. Research instrumentation of the test components provide conventional pressure and temperature measurements as well as metal temperatures measured by IR-photography. The primary data acquisition mode is steady state through a 704 channel multiplexer/digitizer. The test facility was configured as an annular cascade of full coverage film cooled vanes for the initial series of research tests.

  18. Convective heat transfer measurements from a NACA 0012 airfoil in flight and in the NASA Lewis Icing Research Tunnel

    Science.gov (United States)

    Poinsatte, Philip E.; Van Fossen, G. James; Dewitt, Kenneth J.

    1990-01-01

    Local heat transfer coefficients were measured on a smooth and roughened NACA 0012 airfoil. Heat transfer measurements on the 0.533 m chord airfoil were made both in flight on the NASA Lewis Twin Otter Icing Research Aircraft and in the NASA Icing Research Tunnel (IRT). Roughness was obtained by the attachment of uniform 2 mm diameter hemispheres to the airfoil surface in 4 distinct patterns. Flight data were taken for the smooth and roughened airfoil at various Reynolds numbers based on chord in the range 1.24 to 2.50 x 10 (exp 6) and at various angles of attack up to 4 deg. During these flight tests, the free stream velocity turbulence intensity was found to be very low (less than 0.1 percent). Wind tunnel data were acquired in the Reynolds number range 1.20 to 4.25 x 10 (exp t) and at angles of attack from -4 to 8 deg. The turbulence intensity in the IRT was 0.5 to 0.7 percent with the cloud generating sprays off. A direct comparison was made between the results obtained in flight and in the IRT. The higher level of turbulence in the IRT vs. flight had little effect on the heat transfer for the lower Reynolds numbers but caused a moderate increase in heat transfer at the high Reynolds numbers. Roughness generally increased the heat transfer.

  19. Qualification and application of a surface plasmon resonance-based assay for monitoring potential HAHA responses induced after passive administration of a humanized anti Lewis-Y antibody.

    Science.gov (United States)

    Szolar, O H J; Stranner, S; Zinoecker, I; Mudde, G C; Himmler, G; Waxenecker, G; Nechansky, A

    2006-06-16

    A sensitive, surface plasmon resonance (SPR)-based assay monitoring potential human-anti-human antibody (HAHA) reactions against the monoclonal antibody (mAb) IGN311 is presented. The latter is a fully humanized Lewis-Y carbohydrate specific mAb that is currently tested in a passive immune therapy approach in a clinical phase I trial. For the SPR experiments a BIACORE 3000 analyzer was used. The ligand IGN311 was covalently coupled to the carboxy-methylated dextran matrix of a CM5 research grade chip (BIACORE). In the course of a fully nested experimental design, a four parameter logistic equation was identified as appropriate calibration model ranging from 0.3 microg/mL (lower limit of quantitation, LLOQ) to 200 microg/mL (upper limit of quantitation, ULOQ) using an anti-idiotypic mAb ('HAHA mimic') as calibrator. The bias ranged from -2.4% to 5.5% and the intermediate precision expressed as 95% CI revealed values from 5.6% to 8.3%. Specificity was evaluated using six human serum matrices from healthy donors spiked with calibrator at the limit of quantitation (LOQ) with >80% of values being recovered with less than 25% relative error. The qualified assay was applied to monitor potentially induced HAHA reactivity in 11 patients from a clinical phase I trial with passively administered IGN311. Of the 11 patients, one high HAHA responder and several low responders were identified. Protein-G depletion experiments with human serum samples revealed that the observed response is predominantly caused by IgG binding to the ligand. The characteristics of these HAHA responses were all of the so-called 'Type I' which is defined by a peak response around day 15 that decreases from this point steadily suggesting that some kind of tolerance is established. Therefore, this type of HAHA response is regarded as non critical for the patient's safety.

  20. Analysis of strain gage reliability in F-100 jet engine testing at NASA Lewis Research Center

    Science.gov (United States)

    Holanda, R.

    1983-01-01

    A reliability analysis was performed on 64 strain gage systems mounted on the 3 rotor stages of the fan of a YF-100 engine. The strain gages were used in a 65 hour fan flutter research program which included about 5 hours of blade flutter. The analysis was part of a reliability improvement program. Eighty-four percent of the strain gages survived the test and performed satisfactorily. A post test analysis determined most failure causes. Five failures were caused by open circuits, three failed gages showed elevated circuit resistance, and one gage circuit was grounded. One failure was undetermined.

  1. Supporting Research: Environments, Administration and Libraries

    Science.gov (United States)

    MacColl, John; Jubb, Michael

    2011-01-01

    Last year, OCLC Research and the UK's Research Information Network (RIN) undertook a pair of parallel studies in the US and the UK on the theme of research support services in universities (Kroll and Forsman 2010; CIBER 2010). In the US, the library and scholarly information consultancy Kroll Research Associates was commissioned, and in the UK the…

  2. Reporting ethics committee approval in public administration research.

    Science.gov (United States)

    Jordan, Sara R; Gray, Phillip W

    2014-03-01

    While public administration research is thriving because of increased attention to social scientific rigor, lingering problems of methods and ethics remain. This article investigates the reporting of ethics approval within public administration publications. Beginning with an overview of ethics requirements regarding research with human participants, I turn to an examination of human participants protections for public administration research. Next, I present the findings of my analysis of articles published in the top five public administration journals over the period from 2000 to 2012, noting the incidences of ethics approval reporting as well as funding reporting. In explicating the importance of ethics reporting for public administration research, as it relates to replication, reputation, and vulnerable populations, I conclude with recommendations for increasing ethics approval reporting in public administration research.

  3. Potential for comparative public opinion research in public administration

    NARCIS (Netherlands)

    G. Bouckaert (Geert); S.G.J. Van de Walle (Steven); J. K. Kampen (Jarl)

    2005-01-01

    textabstractThe public administration and public services have always taken a marginal place in the political scientists’ behavioural research. Public administration students on the other hand tend to focus on political and administrative elites and institutions, and largely ignored citizens in

  4. Nitrogen Lewis Acids.

    Science.gov (United States)

    Pogoreltsev, Alla; Tulchinsky, Yuri; Fridman, Natalia; Gandelman, Mark

    2017-03-22

    Being a major conception of chemistry, Lewis acids have found countless applications throughout chemical enterprise. Although many chemical elements can serve as the central atom of Lewis acids, nitrogen is usually associated with Lewis bases. Here, we report on the first example of robust and modifiable Lewis acids centered on the nitrogen atom, which provide stable and well-characterized adducts with various Lewis bases. On the basis of the reactivity of nitrogen Lewis acids, we prepared, for the first time, cyclic triazanes, a class of cyclic organic compounds sequentially bearing three all-saturated nitrogen atoms (N-N-N motif). Reactivity abilities of these N-Lewis acids were explained by theoretical calculations. Properties and future applications of nitrogen Lewis acids are intriguing.

  5. Lewy Body Dementia Association

    Science.gov (United States)

    ... promoting scientific advances. Featured LBD Stories & Tributes Dad's Dementia Journey It's been years since my father passed ... I received an email from the Lewy Body Dementia Association about a benefit... Read Story The Lewy ...

  6. Use of administrative medical databases in population-based research.

    Science.gov (United States)

    Gavrielov-Yusim, Natalie; Friger, Michael

    2014-03-01

    Administrative medical databases are massive repositories of data collected in healthcare for various purposes. Such databases are maintained in hospitals, health maintenance organisations and health insurance organisations. Administrative databases may contain medical claims for reimbursement, records of health services, medical procedures, prescriptions, and diagnoses information. It is clear that such systems may provide a valuable variety of clinical and demographic information as well as an on-going process of data collection. In general, information gathering in these databases does not initially presume and is not planned for research purposes. Nonetheless, administrative databases may be used as a robust research tool. In this article, we address the subject of public health research that employs administrative data. We discuss the biases and the limitations of such research, as well as other important epidemiological and biostatistical key points specific to administrative database studies.

  7. High-temperature fatigue in metals - A brief review of life prediction methods developed at the Lewis Research Center of NASA

    Science.gov (United States)

    Halford, G. R.

    1983-01-01

    The presentation focuses primarily on the progress we at NASA Lewis Research Center have made. The understanding of the phenomenological processes of high temperature fatigue of metals for the purpose of calculating lives of turbine engine hot section components is discussed. Improved understanding resulted in the development of accurate and physically correct life prediction methods such as Strain-Range partitioning for calculating creep fatigue interactions and the Double Linear Damage Rule for predicting potentially severe interactions between high and low cycle fatigue. Examples of other life prediction methods are also discussed. Previously announced in STAR as A83-12159

  8. Research on hospital administrators' ethics: an agenda.

    Science.gov (United States)

    Williamson, S; Jauch, L R

    1995-03-01

    This discussion argues that whereas ethically questionable practices have been identified in many industries, the moral consequences of many hospital management decisions make this industry particularly worthy of ethics studies. Because health care, the hospital's product, typically represents more immediate, intimate, and possibly irreversible benefit or harm to its customer, the patient, than does the typical product of general industry, hospital executives should be held to higher ethical standards in their decision making. Yet little is known about the ethical thinking of hospital managers. Kohlberg's moral reasoning development theory and Rest's Defining Issues Test offer the theoretical base and the means to compare the ethical reasoning of hospital executives to that of their nonhospital counterparts in general industry. This research agenda can offer important clues regarding the need to emphasize ethics in health care industry educational programs.

  9. In Occupational Education: The Happy Marriage of Administration and Research

    Science.gov (United States)

    Smith, Ralph B.; Stephens, Kent G.

    1976-01-01

    The Northern California Research Group (NORCAL) organized a series of workshops for occupational administrators designed to provide insight into research procedures and practices in areas including: program effectiveness, job placement services, needs assessment, program evaluation, and follow-up studies. (NHM)

  10. Liquid water content measurements using the Phase Doppler Particle Analyzer in the NASA Lewis Icing Research Tunnel

    Science.gov (United States)

    Rudoff, R. C.; Bachalo, E. J.; Bachalo, W. D.; Oldenburg, J. R.

    1993-01-01

    The performance of a Phase Doppler Particle Analyzer (PDPA) based icing probe suitable for use in icing tunnels and airborne applications is assessed. The instrument is shown to accurately and repeatably measure liquid water content (LWC) to within better than 20 percent of the nominal expected value in the NASA Lewis IRT. This was seen to be true over a wide range of tunnel operating conditions. The principles used by the PDPA for MVD and LWC determination are discussed. Calibration curves for the IRT median volume diameter are also determined and compared to the existing calibration determined via the PMS instruments. As has been shown in previous work, the PDPA is quite repeatable. The results are typically 3 to 5 microns smaller than the existing calibrations for a given run condition. Reasons for these differences are also discussed.

  11. Emergent Paradigm: Critical Realism and Transformative Research in Educational Administration

    Science.gov (United States)

    Egbo, Benedicta

    2005-01-01

    This paper explores the prospects of using critical realism as a guiding philosophy for critical inquiry in the field of educational administration. A relatively recent philosophy in the social sciences, critical realism offers an alternative framework for researchers engaged in empirical work that is aimed at transforming undesirable social…

  12. Need for Practice-Based Research in School Administration

    Science.gov (United States)

    Kowalski, Theodore J.; Place, A. Will; Edmister, Julie; Zigler, Ted

    2009-01-01

    Purpose: This article's first objective is to establish the need for elevating the quantity and quality of practice-based research in school administration. The requirement is addressed in relation to (a) persisting social demands for school reform, (b) heightened demands for evidence-based practice in all professions, and (c) persistent…

  13. Administrative Data Linkage as a Tool for Child Maltreatment Research

    Science.gov (United States)

    Brownell, Marni D.; Jutte, Douglas P.

    2013-01-01

    Linking administrative data records for the same individuals across services and over time offers a powerful, population-wide resource for child maltreatment research that can be used to identify risk and protective factors and to examine outcomes. Multistage de-identification processes have been developed to protect privacy and maintain…

  14. Research priorities for administrative challenges of integrated networks of care.

    Science.gov (United States)

    Pilgrim, Randy; Hilton, Joshua A; Carrier, Emily; Pines, Jesse M; Hufstetler, Greg; Thorby, Suzette; Milling, T J; Cesta, Beth; Hsia, Renee Y

    2010-12-01

    In 2006, the Institute of Medicine (IOM) advanced the concept of "coordinated, regionalized, and accountable emergency care systems" to address significant problems with the delivery of emergency medical care in the United States. Achieving this vision requires the thoughtful implementation of well-aligned, system-level structures and processes that enhance access to emergency care and improve patient outcomes at a sustainable cost. Currently, the delivery of emergency medical care is supported by numerous administrative systems, including economic; reimbursement; legal and regulatory structures; licensure, credentialing, and accreditation processes; medicolegal systems; and quality reporting mechanisms. In addition, many regionalized systems may not optimize patient outcomes because of current administrative barriers that make it difficult for providers to deliver the best care. However, certain administrative barriers may also threaten the sustainability of integration efforts or prevent them altogether. This article identifies significant administrative challenges to integrating networks of emergency care in four specific areas: reimbursement, medical-legal, quality reporting mechanisms, and regulatory aspects. The authors propose a research agenda for indentifying optimal approaches that support consistent access to quality emergency care with improved outcomes for patients, at a sustainable cost. Researching administrative challenges will involve careful examination of the numerous natural experiments in the recent past and will be crucial to understand the impact as we embark on a new era of health reform.

  15. Academic Library Administrators Perceive Value in Their Librarians’ Research

    Directory of Open Access Journals (Sweden)

    Elaine Sullo

    2014-09-01

    Full Text Available A Review of: Perkins, G.H. & Slowik, A.J.W. (2013. The value of research in academic libraries. College & Research Libraries, 74(2, 143-158. Retrieved from http://crl.acrl.org/content/74/2/143.full.pdf+html Abstract Objective – To explore academic library administrators’ perceived value of their librarians’ research, specifically the importance to the profession and the library community. Design – Qualitative, exploratory study using a survey questionnaire. Setting – Academic libraries in the United States of America. Subjects – 23 library administrators. Methods – During the summer of 2010, one of the authors conducted 20-30 minute telephone interviews with 23 academic library administrators. Interviews were recorded and transcribed for coding. Interview questions 1-3 and 8-19 were content-analyzed; the authors described common themes for each of these questions. Items 4-7 had Likert scale response formats, and a mean and standard deviation were computed for each of these items. Main Results – The benefits of librarians’ research included fulfilling tenure-track requirements, enriching relationships with teaching faculty, library faculty recognition, improved services and programs, collaboration with others, research result application to daily issues, development as librarians, and improved knowledge of the research field. The perceived current changes and future issues for university libraries included increased digitization of collections, scholarly communication, and expanded instructional engagement of faculty and students, as well as future economic downturn and budget cuts. Administrators noted several methods that influenced their thinking: professional meetings, reading professional journals, informal discussions with colleagues, and social media such as Facebook and Twitter. Academic library administrators used a variety of methods to support their librarians’ research. These included tenure-track requirements

  16. Cortical Lewy Body Dementia

    Directory of Open Access Journals (Sweden)

    W. R. G. Gibb

    1990-01-01

    Full Text Available In cortical Lewy body dementia the distribution of Lewy bodies in the nervous system follows that of Parkinson's disease, except for their greater profusion in the cerebral cortex. The cortical tangles and plaques of Alzheimer pathology are often present, the likely explanation being that Alzheimer pathology provokes dementia in many patients. Pure cortical Lewy body dementia without Alzheimer pathology is uncommon. The age of onset reflects that of Parkinson's disease, and clinical features, though not diagnostic, include aphasias, apraxias, agnosias, paranoid delusions and visual hallucinations. Parkinsonism may present before or after the dementia, and survival duration is approximately half that seen in Parkinson's disease without dementia.

  17. Lewy body dementias

    DEFF Research Database (Denmark)

    Løkkegaard, Annemette; Korbo, Lise

    2017-01-01

    Dementia with Lewy bodies and Parkinson disease dementia share the same pathophysiology. Together they are called Lewy body dementias and are the second most common type of dementia. Lewy body dementias receive little attention, and patients are often misdiagnosed, leading to less than ideal...... management. In this article, diagnostic criteria combined with imaging and other biomarkers as well as current treatment recommendations are summarized, and some of the challenges for the future are outlined. Refinement of diagnosis and clarification of the pathogenesis are required in search for disease...

  18. Comparative Research: An Approach to Teaching Research Methods in Political Science and Public Administration

    Science.gov (United States)

    Engbers, Trent A

    2016-01-01

    The teaching of research methods has been at the core of public administration education for almost 30 years. But since 1990, this journal has published only two articles on the teaching of research methods. Given the increasing emphasis on data driven decision-making, greater insight is needed into the best practices for teaching public…

  19. Comparative Research: An Approach to Teaching Research Methods in Political Science and Public Administration

    Science.gov (United States)

    Engbers, Trent A

    2016-01-01

    The teaching of research methods has been at the core of public administration education for almost 30 years. But since 1990, this journal has published only two articles on the teaching of research methods. Given the increasing emphasis on data driven decision-making, greater insight is needed into the best practices for teaching public…

  20. Administration

    DEFF Research Database (Denmark)

    Bogen handler om den praksis, vi kalder administration. Vi er i den offentlige sektor i Danmark hos kontorfolkene med deres sagsmapper, computere, telefoner,, lovsamlinger,, retningslinier og regneark. I bogen udfoldes en mangfoldighed af konkrete historier om det administrative arbejde fra...... forskellige områder i den offentlige sektor. Hensigten er at forstå den praksis og faglighed der knytter sig til det administrative arbejde...

  1. Design and reactions of a carbon Lewis base/boron Lewis acid frustrated Lewis pair.

    Science.gov (United States)

    Möricke, Jennifer; Wibbeling, Birgit; Daniliuc, Constantin G; Kehr, Gerald; Erker, Gerhard

    2017-08-28

    The conjugated dienamine 4 selectively adds Piers' borane [HB(C6F5)2] to give the enamine/borane system 5, which features a boratirane structure by internal enamine carbon Lewis base to boron Lewis acid interaction. Compound 5 behaves as a C/B frustrated Lewis pair and undergoes typical addition reactions to benzaldehyde, several nitriles and to sulfur dioxide.This article is part of the themed issue 'Frustrated Lewis pair chemistry'. © 2017 The Author(s).

  2. Significance of Lewis Phenotyping Using Saliva and Gastric Tissue: Comparison with the Lewis Phenotype Inferred from Lewis and Secretor Genotypes

    OpenAIRE

    Yun Ji Hong; Sang Mee Hwang; Taek Soo Kim; Eun Young Song; Kyoung Un Park; Junghan Song; Kyou-Sup Han

    2014-01-01

    Lewis phenotypes using various types of specimen were compared with the Lewis phenotype predicted from Lewis and Secretor genotypes. This is the first logical step in explaining the association between the Lewis expression and Helicobacter pylori. We performed a study of the followings on 209 patients who underwent routine gastroscopy: erythrocyte and saliva Lewis phenotyping, gastric Lewis phenotyping by the tissue array, and the Lewis and Secretor genes genotyping. The results of phenotypin...

  3. Psychological Research With Administrative Data Sets: An Underutilized Strategy for Mental Health Services Research.

    Science.gov (United States)

    Walkup, James T; Yanos, Philip T

    2005-10-01

    A key element in the identity of professional psychologists is their commitment to base practice on the best knowledge available about a problem being tackled. Although administrative data (e.g., records of provider billing and procedures) can often shed light on the dark areas of the complex U.S. health care system, psychologists make notably little use of them. Experience teaches that decisions must often be made despite the absence of "gold standard" knowledge from the well-designed, controlled studies learned in graduate school. Increased involvement of psychologists in work using administrative data can improve service provision but requires that psychologists adopt unaccustomed approaches to research. The authors discuss administrative data's strengths and limitations, recent progress made in using them, how psychologists can acquire and use low-cost information from administrative data, and examples of questions that can be answered.

  4. Entrepreneurship in Cyberspace Research of Mru Management and Administration Students

    Directory of Open Access Journals (Sweden)

    Mindaugas Kiškis

    2013-01-01

    Full Text Available Youth entrepreneurship is one of the European Union’s public policy priorities. Student entrepreneurship in this context is particularly important as academic studies at the university shall develop an entrepreneurial personality. Student entrepreneurship is not widely examined in Lithuanian scholarly work. This phenomenon tends to be analyzed in the context of development of general entrepreneurial skills. There is no prior work on student entrepreneurship in cyberspace—most notably there is no empirical research in this area. This situation emphasizes the need for empirical studies of student entrepreneurship. The purpose of this article is to analyze student entrepreneurship in cyberspace status quo at Mykolas Romeris University (MRU. This research objective was chosen in order to determine the current status and to enable a reference for further research of student entrepreneurship in cyberspace. Additional practical goals are adopted, namely—based on the results of this study, to identify development guidelines for study programs as well as the “Entrepreneurship in Cyberspace” discipline taught in a postgraduate studies at MRU in order to focus them on the needs of future postgraduate students. The research was conducted using a survey method. Before the research three hypotheses were proposed: 1 MRU students are more enterprising than the statistical resident of Lithuania; 2 student entrepreneurship education in Management and Administration studies is inadequate; 3 students need specialized knowledge of entrepreneurship in cyberspace. After the analysis of gathered data from students all three hypotheses were confirmed: students are more entrepreneurial then the general population of Lithuania, entrepreneurial education at the university is insufficient and there is a need among students for specialized knowledge in the field of e-business. Follow-up study of the negative dynamics of student entrepreneurship should be carried

  5. Entrepreneurship in Cyberspace Research of Mru Management and Administration Students

    Directory of Open Access Journals (Sweden)

    Mindaugas Kiškis

    2012-07-01

    Full Text Available Youth entrepreneurship is one of the European Union’s public policy priorities. Student entrepreneurship in this context is particularly important as academic studies at the university shall develop an entrepreneurial personality.Student entrepreneurship is not widely examined in Lithuanian scholarly work. This phenomenon tends to be analyzed in the context of development of general entrepreneurial skills. There is no prior work on student entrepreneurship in cyberspace—most notably there is no empirical research in this area. This situation emphasizes the need for empirical studies of student entrepreneurship.The purpose of this article is to analyze student entrepreneurship in cyberspace status quo at Mykolas Romeris University (MRU. This research objective was chosen in order to determine the current status and to enable a reference for further research of student entrepreneurship in cyberspace. Additional practical goals are adopted, namely—based on the results of this study, to identify development guidelines for study programs as well as the “Entrepreneurship in Cyberspace” discipline taught in a postgraduate studies at MRU in order to focus them on the needs of future postgraduate students.The research was conducted using a survey method. Before the research three hypotheses were proposed:1 MRU students are more enterprising than the statistical resident of Lithuania;2 student entrepreneurship education in Management and Administration studies is inadequate;3 students need specialized knowledge of entrepreneurship in cyberspace.After the analysis of gathered data from students all three hypotheses were confirmed: students are more entrepreneurial then the general population of Lithuania, entrepreneurial education at the university is insufficient and there is a need among students for specialized knowledge in the field of e-business.Follow-up study of the negative dynamics of student entrepreneurship should be carried out in the

  6. Lewis Research Center battery overview

    Science.gov (United States)

    Odonnell, Patricia

    1993-01-01

    The topics covered are presented in viewgraph form and include the following: the Advanced Communications Technology Satellite; the Space Station Freedom (SSF) photovoltaic power module division; Ni/H2 battery and cell design; individual pressure vessel (IPV) nickel-hydrogen cell testing SSF support; the LeRC Electrochemical Technology Branch; improved design IPV nickel-hydrogen cells; advanced technology for IPV nickel-hydrogen flight cells; a lightweight nickel-hydrogen cell; bipolar nickel-hydrogen battery development and technology; aerospace nickel-metal hydride cells; the NASA Sodium-Sulfur Cell Technology Flight Experiment; and the lithium-carbon dioxide battery thermodynamic model.

  7. Lewis Acid Catalyzed Benzylic Bromination

    OpenAIRE

    Shibatomi, Kazutaka; Zhang, Yanhua; Yamamoto, Hisashi

    2008-01-01

    Lewis acid catalyzed bromination on aromatic side chain was achieved efficiently by using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) as a bromination reagent under mild conditions. Zirconium(IV) chloride showed the highest catalytic activity for the benzylic bromination. It was revealed that the present Lewis acid catalysis proceeds via the radical generation pathway. In contrast to Lewis acid catalysis, Brønsted acid promoted aromatic ring bromination without any benzylic bromination. Monobro...

  8. Lewis Steelhead Genetics - Lewis River Steelhead Reintroduction

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Rainbow trout and steelhead consist of the same species and often inhabit the similar habitat types within the same watershed. Although their life histories differ...

  9. Barker's Behavior Setting Theory: A Useful Conceptual Framework for Research on Educational Administration.

    Science.gov (United States)

    Eklund, S. J.; Scott, M. M.

    1985-01-01

    Research in educational administration needs a coherent empirical base for a comprehensive, ecologically valid theory of administration. This paper describes Roger Barker's Behavior Setting Theory and promotes it as a broad-based conceptual framework for research on educational administration. (Author/TE)

  10. A Biography of Distinguished Scientist Gilbert Newton Lewis (by Edward S. Lewis)

    Science.gov (United States)

    Harris, Reviewed By Harold H.

    1999-11-01

    until 1904, when he accepted a position that would not be considered a shrewd career move: Superintendent of Weights and Measures in Manila, Philippines! He was there only one year, but it was apparently a productive time, both in a minimally equipped laboratory and with the possible nascence of some of his ideas about bonding. In 1905, Lewis accepted a staff position at MIT, under A. A. Noyes, where he remained until 1912. At MIT, he continued his experimental work on thermodynamic systems and the development of modern thermodynamics, following the lead of J. W. Gibbs, whose work was being largely ignored by other chemists. As Noyes moved increasingly into administrative responsibilities, Lewis took over more and more of the supervision of scientific work in the laboratory. It was the capable job that he did for Noyes that led to his being offered a Professorship and Chair of the College of Chemistry at the University of California, Berkeley. The same spirit of adventure that took Lewis to Manila may be what led to his moving to scientifically backward California. In 1912, there was no serious science going on the Left Coast, and Berkeley was isolated from the nearest civilization (Chicago) by days of travel. Lewis initiated the expansion of great science westward, not only to Berkeley, but also to Caltech (in those days Throop Institute), UCLA, and Stanford. By dint of his contributions to thermodynamics and bonding theory (suggesting that electrons bond in pairs, long before there was quantum mechanical justification for such a strange idea), and his organizational and leadership talents, he turned the Berkeley Chemistry Department from a nonentity into one of the finest anywhere. Later in his career, he contributed to the understanding of the role of isotopes in chemistry and physics. This biography includes a useful listing of Lewis's 168 scientific publications. In an age when many renowned scientists have multiples of this number, it is perhaps good to be

  11. Dementia with Lewy bodies.

    Science.gov (United States)

    McKeith, Ian G; Burn, David J; Ballard, Clive G; Collerton, Daniel; Jaros, Evelyn; Morris, Chris M; McLaren, Andrew; Perry, Elaine K; Perry, Robert; Piggott, Margaret A; O'Brien, John T

    2003-01-01

    The objective was to summarize recent findings about the clinical features, diagnosis and investigation of dementia with Lewy (DLB) bodies, together with its neuropathology, neurochemistry and genetics. Dementia with Lewy bodies (DLB) is a primary, neurodegenerative dementia sharing clinical and pathological characteristics with both Parkinson's disease (PD) and Alzheimer's disease (AD). Antiubiquitin immunocytochemical staining, developed in the early 1990s, allowed the frequency and distribution of cortical LBs to be defined. More recently, alpha-synuclein antibodies have revealed extensive neuritic pathology in DLB demonstrating a neurobiological link with other "synucleinopathies" including PD and multiple system atrophy (MSA). The most significant correlates of cognitive failure in DLB appear to be with cortical LB and Lewy neurites (LNs) rather than Alzheimer type pathology. Clinical diagnostic criteria for DLB, published in 1996, have been subjected to several validation studies against autopsy findings. These conclude that although diagnostic specificity is high (range 79- 100%, mean 92%), sensitivity is lower (range 0- 83 %, mean, 49%). Improved methods of case detection are therefore required. Fluctuating impairments in attention, visual recognition and construction are more indicative of DLB than AD. Relative preservation of medial temporal lobe volume on structural MRI and the use of SPECT tracers for regional blood flow and the dopamine transporter are the most reliable current biomarkers for DLB. There are no genetic or CSF tests recommended for the diagnosis of DLB at present. Between 15 and 20% of all elderly demented cases reaching autopsy have DLB, making it the most common cause of degenerative dementia after AD. Exquisite, not infrequently fatal, sensitivity to neuroleptic drugs and encouraging reports of the effects of cholinesterase inhibitors on cognitive, psychiatric and neurological features, mean that an accurate diagnosis of DLB is more

  12. Reflecting on the role of literature in qualitative public administration research:learning from grounded theory

    NARCIS (Netherlands)

    L.G. Tummers (Lars); N. Karsten (Niels)

    2012-01-01

    textabstractWhen undertaking qualitative research, public administration scholars must walk a thin line between being theoretically sensitive and imposing preconceived ideas on their work. This article identifies opportunities and pitfalls in using literature in qualitative public administration res

  13. Lewis base activation of Lewis acids: development of a Lewis base catalyzed selenolactonization.

    Science.gov (United States)

    Denmark, Scott E; Collins, William R

    2007-09-13

    The concept of Lewis base activation of Lewis acids has been applied to the selenolactonization reaction. Through the use of substoichiometric amounts of Lewis bases with "soft" donor atoms (S, Se, P) significant rate enhancements over the background reaction are seen. Preliminary mechanistic investigations have revealed the resting state of the catalyst as well as the significance of a weak Brønsted acid promoter.

  14. Significance of Lewis Phenotyping Using Saliva and Gastric Tissue: Comparison with the Lewis Phenotype Inferred from Lewis and Secretor Genotypes

    Directory of Open Access Journals (Sweden)

    Yun Ji Hong

    2014-01-01

    , and le59 alleles was 74.6%, 21.3%, 3.1%, and 1.0%, respectively, among 418 alleles. The saliva Lewis phenotype was completely consistent with the Lewis phenotype inferred from Lewis and Secretor genotypes, but that of gastric mucosa could not be predicted from genotypes. Lewis phenotyping using erythrocytes is only adequate for transfusion needs. Saliva testing for the Lewis phenotype is a more reliable method for determining the peripheral Lewis phenotype of an individual and the gastric Lewis phenotype must be used for the study on the association between Helicobacter pylori and the Lewis phenotype.

  15. Structured Observation of School Administrator Work Activities: Methodological Limitations and Recommendations for Research, Part II.

    Science.gov (United States)

    Pitner, Nancy J.; Russell, James S.

    1986-01-01

    This paper critically reviews administrator work activity studies which follow the research of Henry Mintzberg. It discusses directions for future research using qualitative and quantitative methods and discourages research that relies solely on Mintzberg's structure. (Author/JAZ)

  16. Organometallic frustrated Lewis pair chemistry.

    Science.gov (United States)

    Erker, Gerhard

    2011-08-07

    Frustrated Lewis pairs are playing an increasingly important role in organometallic chemistry. Examples are presented and discussed where organometallic systems themselves serve as the Lewis base or Lewis acid components in frustrated Lewis pair chemistry, mostly through their attached functional groups. Activation of dihydrogen takes place easily in many of these systems. This may lead to the generation of novel catalyst systems but also in many cases to the occurrence of specific reactions at the periphery of the organometallic frameworks. Increasingly, FLP reactions are used to carry out functional group conversions in organometallic systems under mild reaction conditions. The limits of typical FLP reactivity are explored with selected organometallic examples, a discussion that points toward new developments, such as the discovery of facile new 1,1-carboboration reactions. Learning more and more about the broad spectrum of frustrated Lewis pair chemistry helps us to find novel reactions and applications.

  17. Inferential Statistics and the Use of Administrative Data in US Educational Research

    Science.gov (United States)

    Gibbs, Benjamin G.; Shafer, Kevin; Miles, Aaron

    2017-01-01

    While the use of inferential statistics is a nearly universal practice in the social sciences, there are instances where its application is unnecessary and potentially misleading. This is true for a portion of research using administrative data in educational research in the United States. Surveying all research articles using administrative data…

  18. 跨越古典与新古典的边界——刘易斯拐点研究新进展%Across the Border of Classical and Neoclassical:Newest Research on Lewis Turning Point

    Institute of Scientific and Technical Information of China (English)

    吴垠

    2012-01-01

    刘易斯拐点是指发展中国家从古典经济条件跨越到新古典经济条件时发展阶段出现重大转折点的时间段,其核心标志是劳动力从过剩逐渐转为短缺。这一衍生于发展经济学的理论命题,近年来越来越具有了“中国化”和“跨学科”的研究趋势。学者们的观点虽有不同,但研究的热情却十分高涨。鉴于此,本文将对:刘易斯拐点含义的理解;拐点成因的解析;刘易斯模型本身是否有缺陷;开放经济条件下的刘易斯拐点问题;刘易斯拐点“中国化”的微观机制分析;刘易斯拐点期中国社会政策与制度变迁等问题的研究新进展作一综述,以期深化对该命题的理解并提出进一步可能的热点研究方向。%Lewis turning point (LTP) refers to the periods of great turning point during development stages which develo- ping countries across from the classical economic conditions to neo-classical economic conditions,its core logo is the surplus la- bor force in developing countries has been turned into a shortage. This theoretical propositions derived from development eco- nomics has more and more characteristics with the "Chinese Style" and "interdisciplinary research trend" in recent years. Re- turn to Lewis's classic dual economics speaking to analyze the LTP theory, or according to the new phenomena and new ques- tions in evolution of the urban and rural labor market development in China and other developing countries to further reading and developing "Lewis Turning Point" theory, should make it have more fresh times characteristics and the universal explana- tory power? Although scholars have different views, the researching enthusiasm is very high. In view of this, this paper will re- view the new progress of LTP researching: the understanding of Lewis turning point meaning; the causes of turning point analyti- cal;whether the Lewis' model itself is flawed;Lewis

  19. DatSCAN In Differential Diagnostics of Lewy Body Disease.

    Science.gov (United States)

    Luzny, Jan; Ivanova, Katerina

    2016-06-01

    Differential diagnosis between Lewy body disease and Alzheimer´s disease might be difficult because of similarities of clinical symptoms in both neurodegenerative diseases. DatSCAN is a modern functional neuroimmaging method which differentiates between this similar diseases and helps in correct treatment strategy. We report our positive experience with DatSCAN in differentiating Lewy body disease from Alzheimer´s disease. This is a case report of a woman with Lewy body disease, initially diagnosed as Alzheimer´s disease. DatSCAN neuroimmaging method was used in differential diagnosis of dementia. Memory impairment, impaired activities of daily living, sleep and behavioral disturbances were present in our case. Donepezil was well tolerated, but haloperidol administration was followed by development of severe dystonia. DatSCAN showed deficient dopaminergic presynaptic transport in substantia nigra and striatum. This finding is typical for Lewy body disease not for Alzheimer´s disease. DatSCAN neuroimmaging is a suitable method for differentiating Lewy body disease from Alzheimer´s disease. Deficient dopaminergic presynaptic transport in substantia nigra and striatum is typical for Lewy body disease.

  20. 78 FR 36591 - David M. Lewis, D.M.D., Dismissal of Proceeding

    Science.gov (United States)

    2013-06-18

    ... Enforcement Administration David M. Lewis, D.M.D., Dismissal of Proceeding On December 5, 2012, the Deputy... to Show Cause to David M. Lewis, D.M.D. (Registrant), of Sacramento, California. The Show Cause Order..., according to the DI, is the Registrant's attorney. However, `` umerous Federal Courts have held that `...

  1. Distinctive research patterns on public sector performance measurement of public administration and accounting disciplines

    NARCIS (Netherlands)

    van Helden, G. Jan; Johnsen, Age; Vakkuri, Jarmo

    2008-01-01

    This article explores distinctive research patterns of public administration and accounting disciplines concerning public sector performance measurement (PSPM). Our review shows that accounting researchers from Europe investigate reasons for limited PM use and factors explaining a rational or symbol

  2. Academic Library Administrators Perceive Value in Their Librarians’ Research

    OpenAIRE

    Elaine Sullo

    2014-01-01

    A Review of: Perkins, G.H. & Slowik, A.J.W. (2013). The value of research in academic libraries. College & Research Libraries, 74(2), 143-158. Retrieved from http://crl.acrl.org/content/74/2/143.full.pdf+html Abstract Objective – To explore academic library administrators’ perceived value of their librarians’ research, specifically the importance to the profession and the library community. Design – Qualitative, exploratory study using a survey questionnaire. Setting –...

  3. A View from within: How Doctoral Students in Educational Administration Develop Research Knowledge and Identity

    Science.gov (United States)

    Murakami-Ramalho, Elizabeth; Militello, Matthew; Piert, Joyce

    2013-01-01

    This study reports on experiences of doctoral students in educational administration at a time when the effectiveness of programs preparing practitioners and academics in this field are being questioned. Concerns related to how students in educational administration developed knowledge about research and identity as researchers were closely…

  4. Academic Administrator Influence on Institutional Commitment to Open Access of Scholarly Research

    Science.gov (United States)

    Reinsfelder, Thomas L.

    2012-01-01

    This quantitative study investigated the interrelationships among faculty researchers, publishers, librarians, and academic administrators when dealing with the open access of scholarly research. This study sought to identify the nature of any relationship between the perceived attitudes and actions of academic administrators and an…

  5. 75 FR 24773 - Research and Innovative Technology Administration Advisory Council on Transportation Statistics...

    Science.gov (United States)

    2010-05-05

    ... Bureau of Transportation Statistics Research and Innovative Technology Administration Advisory Council on Transportation Statistics; Notice of Meeting AGENCY: Research and Innovative Technology Administration, U.S... on Transportation Statistics (ACTS). The meeting will be held on Friday, June 4, 2010, from 9 a.m....

  6. Academic Administrator Influence on Institutional Commitment to Open Access of Scholarly Research

    Science.gov (United States)

    Reinsfelder, Thomas L.

    2012-01-01

    This quantitative study investigated the interrelationships among faculty researchers, publishers, librarians, and academic administrators when dealing with the open access of scholarly research. This study sought to identify the nature of any relationship between the perceived attitudes and actions of academic administrators and an…

  7. 49 CFR 1.46 - Delegations to the Administrator of the Research and Innovative Technology Administration.

    Science.gov (United States)

    2010-10-01

    ... and meetings dealing with transportation R&D. (9) Manage the strategic planning process for... university participation in the planning, conduct and analysis of transportation research. (15) Manage... Council Committee on the Federal Transportation R&D Strategic Planning Process. (c) Advanced vehicle...

  8. Significance of Lewis phenotyping using saliva and gastric tissue: comparison with the Lewis phenotype inferred from Lewis and secretor genotypes.

    Science.gov (United States)

    Hong, Yun Ji; Hwang, Sang Mee; Kim, Taek Soo; Song, Eun Young; Park, Kyoung Un; Song, Junghan; Han, Kyou-Sup

    2014-01-01

    Lewis phenotypes using various types of specimen were compared with the Lewis phenotype predicted from Lewis and Secretor genotypes. This is the first logical step in explaining the association between the Lewis expression and Helicobacter pylori. We performed a study of the followings on 209 patients who underwent routine gastroscopy: erythrocyte and saliva Lewis phenotyping, gastric Lewis phenotyping by the tissue array, and the Lewis and Secretor genes genotyping. The results of phenotyping were as follows [Le(a-b-), Le(a+b-), Le(a-b+), and Le(a+b+), respectively, in order]: erythrocyte (12.4%, 25.8%, 61.2%, and 0.5%); saliva (2.4%, 27.3%, 70.3%, and 0.0%); gastric mucosa (8.1%, 6.7%, 45.5%, and 39.7%). The frequency of Le, le (59/508) , le (59/1067) , and le (59) alleles was 74.6%, 21.3%, 3.1%, and 1.0%, respectively, among 418 alleles. The saliva Lewis phenotype was completely consistent with the Lewis phenotype inferred from Lewis and Secretor genotypes, but that of gastric mucosa could not be predicted from genotypes. Lewis phenotyping using erythrocytes is only adequate for transfusion needs. Saliva testing for the Lewis phenotype is a more reliable method for determining the peripheral Lewis phenotype of an individual and the gastric Lewis phenotype must be used for the study on the association between Helicobacter pylori and the Lewis phenotype.

  9. Symptoms of Lewy Body Dementia

    Science.gov (United States)

    ... Treatment Options Join the fight against LBD! Donate Symptoms Lewy body dementia symptoms and diagnostic criteria Every person with LBD is ... or Dementia plus one or more suggestive features. Symptoms Explained In this section we'll discuss each ...

  10. 7 CFR 2.65 - Administrator, Agricultural Research Service.

    Science.gov (United States)

    2010-01-01

    ... of the health and welfare of people; human nutrition; and international food and agriculture pursuant... services includes budget, finance, personnel, procurement, property management, communications, paperwork... materials, including the results of nutrition research, training methods, procedures, and other materials...

  11. The role of administrative data in the big data revolution in social science research.

    Science.gov (United States)

    Connelly, Roxanne; Playford, Christopher J; Gayle, Vernon; Dibben, Chris

    2016-09-01

    The term big data is currently a buzzword in social science, however its precise meaning is ambiguous. In this paper we focus on administrative data which is a distinctive form of big data. Exciting new opportunities for social science research will be afforded by new administrative data resources, but these are currently under appreciated by the research community. The central aim of this paper is to discuss the challenges associated with administrative data. We emphasise that it is critical for researchers to carefully consider how administrative data has been produced. We conclude that administrative datasets have the potential to contribute to the development of high-quality and impactful social science research, and should not be overlooked in the emerging field of big data. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  12. Putting Theory into Theory: Thematic Value of Research in Public Administration Teaching

    Science.gov (United States)

    Barber, Stephen; Luke, Peter

    2016-01-01

    Research can be a powerful tool informing public administration teaching. This article takes the distinctive approach of exploring its use through the prism of the research itself by considering 10 publications by the article's authors. The existing literature revolves around students learning about the craft of research or research findings. By…

  13. 2006 Puget Sound LiDAR Consortium (PSLC) Topographic LiDAR: Lewis County, WA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Watershed Sciences, Inc. collected Light Detection and Ranging (LiDAR) data of Western Lewis County for the Puget Sound LiDAR Consortium. This data set covers...

  14. 2005 Puget Sound LiDAR Consortium (PSLC) Topographic LiDAR: Lewis County

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Terrapoint collected Light Detection and Ranging (LiDAR) data for the Lewis County project of 2005. The project site covered approximately 223 square miles, divided...

  15. 2009 Puget Sound LiDAR Consortium (PSLC) Topographic LiDAR: Lewis County, Washington

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Watershed Sciences, Inc. (WSI) collected Light Detection and Ranging (LiDAR) data for the Lewis County survey area for the Puget Sound LiDAR Consortium. This data...

  16. Student Affairs administrator shares research on Millennial Generation

    OpenAIRE

    DeLauder, Rachel

    2006-01-01

    Edward Spencer of Blacksburg, Va., associate vice president for student affairs at Virginia Tech, conducted a presentation at the North Cross School in Roanoke, Va., about his research on the Millennial Generation, which represents Americans born between 1982 and the present. The presentation, titled"Understanding and Working with Millennials," focused on the changing relationship between parents and this new generation and how parents can prepare them for success in higher education and the ...

  17. Considerations of Administrative Licensure, Provider Type, and Leadership Quality: Recommendations for Research, Policy, and Practice

    Science.gov (United States)

    Hackmann, Donald G.

    2016-01-01

    This article reviews U.S. administrative licensure regulations, focusing on type of school leader licensure, provider types, and leadership quality. Licensure obtained through university-based and alternative routes is examined. Due to limited research on alternative school administrative licensure, regulations in medicine, psychology,…

  18. Academic Librarians and Research: A Study of Canadian Library Administrator Perspectives

    Science.gov (United States)

    Berg, Selinda Adelle; Jacobs, Heidi L. M.; Cornwall, Dayna

    2013-01-01

    Within the literature exploring the role of research in academic librarianship, very little attention has been paid to the perspectives of upper library administrators. This perspective is critical because library administrators play a key role in hiring, evaluating, supporting, promoting, and tenuring professional librarians. As a way of bringing…

  19. Retrospectives, current valences and prospective dimensions of research at the Academy of Public Administration

    Directory of Open Access Journals (Sweden)

    Aurel SÎMBOTEANU

    2016-12-01

    Full Text Available The present study is an attempt to identify the social determinants, which initiated and facilitated the content and evolution of the scientific research of the administrative phenomenon in the Republic of Moldova after the declaration of independence. It also elucidates the current valences and perspectives of this activity in the context of the provisions of the recently adopted Research Strategy of the Academy of Public Administration for the period 2016-2020.

  20. Reflecting on the role of literature in qualitative public administration research:learning from grounded theory

    OpenAIRE

    2012-01-01

    textabstractWhen undertaking qualitative research, public administration scholars must walk a thin line between being theoretically sensitive and imposing preconceived ideas on their work. This article identifies opportunities and pitfalls in using literature in qualitative public administration research. Whereas the opportunities are already well known within the discipline, the pitfalls remain underexposed. We identify potential pitfalls by using insights from the grounded theory approach. ...

  1. How Do Lipids Localize in Lewy Bodies?

    NARCIS (Netherlands)

    Chaudhary, Himanshu; Subramaniam, Vinod; Claessens, Mireille

    2014-01-01

    Lewy bodies are the pathological hallmark of Parkinson's disease (PD). While fibrillar α-synuclein (αS) is the main protein component of Lewy bodies, these structures also contain lipids. To elucidate the presence of lipids in Lewy bodies, we investigated the interaction of lipids with monomeric and

  2. Lewis and Clark as Naturalists.

    Science.gov (United States)

    Smithsonian Institution, Washington, DC. National Museum of Natural History.

    Intended for use in elementary and high school education, this Web site includes a teacher's guide and three lesson plans. The site contains images of museum specimens, scientific drawings, and field photos of the plant and animal species observed by Meriwether Lewis and William Clark, along with journal excerpts, historical notes, and references…

  3. 78 FR 38846 - Potato Research and Promotion Plan; Amend the Administrative Committee Structure and Delete the...

    Science.gov (United States)

    2013-06-28

    ...; ] DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 1207 Potato Research and Promotion Plan... of the Administrative Committee (Committee) of the U.S. Potato Board (Board) and deleting the Board's mailing address from the Potato Research and Promotion Plan. The Plan is administered by the Board...

  4. Dementia with Lewy Bodies

    Science.gov (United States)

    ... Page NINDS Wernicke-Korsakoff Syndrome Information Page NINDS Whiplash Information Page NINDS Infantile Spasms Information Page NINDS ... Support Library Clinical Research Next Steps Pre-Funding: After Review Terms of Award Pre-Award Start-up ...

  5. Lewy Body Disease Treatment

    Science.gov (United States)

    ... Association, Inc. Connect With Us LinkedIn facebook twitter google youtube lbda.org Home Learn About LBD Find Support Resources Research Ways to Give About Us Contact Us Join LBDA Forum Donate Now Login Patients & Caregivers Professionals Volunteer Shop Search Sitemap ...

  6. Californian Genius: Lewis Terman's Gifted Child in Regional Perspective

    Science.gov (United States)

    Beauvais, Clémentine

    2016-01-01

    This article pays attention to the regional embeddedness of early research on giftedness, looking principally at the works of Lewis Terman and his peers, between the 1910s and 1930s. The rhetoric, ideology, and aesthetics of giftedness in those early works were, I argue, stamped by the context and imaginary of Progressive-Era California and shaped…

  7. Californian Genius: Lewis Terman's Gifted Child in Regional Perspective

    Science.gov (United States)

    Beauvais, Clémentine

    2016-01-01

    This article pays attention to the regional embeddedness of early research on giftedness, looking principally at the works of Lewis Terman and his peers, between the 1910s and 1930s. The rhetoric, ideology, and aesthetics of giftedness in those early works were, I argue, stamped by the context and imaginary of Progressive-Era California and shaped…

  8. Game analysis on Huaihe River anti-pollution administration mechanism and policy research

    Institute of Scientific and Technical Information of China (English)

    Wang Lei; Zhou Meihua

    2006-01-01

    Based on the literature review of environmental anti-pollution researches, this paper analyzes the administrative mechanism of Huaihe River anti-pollution with game theo ry. Based on the quantitative analysis on three corresponding game models with four players including local residents, enterprises, local governments and competent authorities at higher levels, this paper demonstrates four main shortcomings of current administrative mechanism of Huaihe River anti-pollution system, including low emission cost, low connivance cost, overemphasis on heavy, fine of the enterprises,neglect of the punishment on the local departments and intersected administrative mechanism. This paper sets up antipollution administrative mechanism, combining economic method with noneconomic method, government control with market mechanism, and introducing public participation. At last, this paper proposes policies, such as implementing emissions trading system, reforming public participation system, and reforming government's environmental protection mechanism to promote law enforcement.

  9. LeaderBeing: Critical Reflections on Context, Character and Challenge in the Culture of Research and Its Administration

    Science.gov (United States)

    Gabriele, Edward F.; Caines, Vaughan V.

    2014-01-01

    Servant leadership is a critical concept for understanding the ongoing importance of research administration as a central profession of service within the culture of research itself. The leadership of research administrators is both a unique gift and a challenge to the research culture. To ensure the continued productivity of the research…

  10. Alternative model for administration and analysis of research-based assessments

    Science.gov (United States)

    Wilcox, Bethany R.; Zwickl, Benjamin M.; Hobbs, Robert D.; Aiken, John M.; Welch, Nathan M.; Lewandowski, H. J.

    2016-06-01

    Research-based assessments represent a valuable tool for both instructors and researchers interested in improving undergraduate physics education. However, the historical model for disseminating and propagating conceptual and attitudinal assessments developed by the physics education research (PER) community has not resulted in widespread adoption of these assessments within the broader community of physics instructors. Within this historical model, assessment developers create high quality, validated assessments, make them available for a wide range of instructors to use, and provide minimal (if any) support to assist with administration or analysis of the results. Here, we present and discuss an alternative model for assessment dissemination, which is characterized by centralized data collection and analysis. This model provides a greater degree of support for both researchers and instructors in order to more explicitly support adoption of research-based assessments. Specifically, we describe our experiences developing a centralized, automated system for an attitudinal assessment we previously created to examine students' epistemologies and expectations about experimental physics. This system provides a proof of concept that we use to discuss the advantages associated with centralized administration and data collection for research-based assessments in PER. We also discuss the challenges that we encountered while developing, maintaining, and automating this system. Ultimately, we argue that centralized administration and data collection for standardized assessments is a viable and potentially advantageous alternative to the default model characterized by decentralized administration and analysis. Moreover, with the help of online administration and automation, this model can support the long-term sustainability of centralized assessment systems.

  11. The Incidence and Types of Occupational Role Stress among University Research Administrators

    Science.gov (United States)

    Katsapis, Christine C. A.

    2012-01-01

    This study explored the types of stressors prevalent in the self-reports of university research administrators (URAs) and examined whether or not the degree or type of role stress was influenced by: a) the affiliation of their office unit within their institution, or b) their type. Randomly selected members of NCURA were invited via e-mail to…

  12. Factors Affecting the Identification of Research Problems in Educational Administration Studies

    Science.gov (United States)

    Yalçin, Mikail; Bektas, Fatih; Öztekin, Özge; Karadag, Engin

    2016-01-01

    The purpose of this study is to reveal the factors that affect the identification of research problems in educational administration studies. The study was designed using the case study method. Criterion sampling was used to determine the work group; the criterion used to select the participants was that of having a study in the field of…

  13. Mapping the Field of Educational Administration Research: A Journal Citation Network Analysis

    Science.gov (United States)

    Wang, Yinying; Bowers, Alex J.

    2016-01-01

    Purpose: The purpose of this paper is to uncover how knowledge is exchanged and disseminated in the educational administration research literature through the journal citation network. Design/ Methodology/Approach: Drawing upon social network theory and citation network studies in other disciplines, the authors constructed an educational…

  14. Energy Research and Development Administration, Division of Safety, Standards, and Compliance respirator manual

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, D.D.; Hack, A.L.; Held, B.J.; Revoir, W.H.

    1976-05-01

    The manual has been prepared to provide technical information for contractors of the Energy Research and Development Administration (ERDA) on the application of respiratory protective devices for protection against airborne contaminants, both radioactive and nonradioactive. The various elements of a respirator program including selection and maintenance of equipment and training of personnel are described to assist in establishing adequate programs.

  15. Administrative Staff Members' Job Competency and Their Job Satisfaction in a Korean Research University

    Science.gov (United States)

    Jung, Jisun; Shin, Jung Cheol

    2015-01-01

    The purpose of this study is to explore the impact of administrative staff's job competency on their job satisfaction in a Korean research university. We conceptualized job satisfaction into three subcomponents: satisfaction in the job field, in the workplace, and with the actual task. In the regression analysis, we included demographics, inner…

  16. Supplemental testimony of John A. Patterson US Energy Research and Development Administration on Uranium Resources Availability

    Energy Technology Data Exchange (ETDEWEB)

    Patterson, J.A.

    1977-07-19

    This testimony reviews information available from the Energy Research and Development Administration (ERDA) on the domestic uranium-resource situation and the outlook for development of additional domestic supplies, availability of foreign uranium, and the relationship of uranium supply to planned nuclear generating capacity.

  17. Administrative Staff Members' Job Competency and Their Job Satisfaction in a Korean Research University

    Science.gov (United States)

    Jung, Jisun; Shin, Jung Cheol

    2015-01-01

    The purpose of this study is to explore the impact of administrative staff's job competency on their job satisfaction in a Korean research university. We conceptualized job satisfaction into three subcomponents: satisfaction in the job field, in the workplace, and with the actual task. In the regression analysis, we included demographics, inner…

  18. Demands of proper administrative conduct A research project into the ombudsprudence of the Dutch National Ombudsman

    NARCIS (Netherlands)

    Langbroek, P.M.; Rijpkema, P.

    2006-01-01

    In this article we explain and summarize a research project on the content and development of principles of proper administrative conduct as operated in complaints proceedings before the Dutch National Ombudsman and some local Ombudsman institutions. It shows how the project evolved into mainly a pr

  19. From digital positivism and administrative big data analytics towards critical digital and social media research!

    OpenAIRE

    Fuchs, Christian

    2017-01-01

    This essay argues for a paradigm shift in the study of the Internet and digital/social media. Big data analytics is the dominant paradigm. It receives large amounts of funding, is administrative and a form of digital positivism. Critical social media research is an alternative approach that combines critical social media theory, critical digital methods and critical-realist social media research ethics. Strengthening the second approach is a material question of power in academia.

  20. Frustrated Lewis pairs: Design and reactivity

    Indian Academy of Sciences (India)

    Sanjoy Mukherjee; Pakkirisamy Thilagar

    2015-02-01

    The interaction of a Lewis acid with a Lewis base results in the formation of a Lewis acid–base adduct. Understanding Lewis acids and bases is central to conceptualizing chemical interactions and constitutes a major portion of metal–ligand chemistry. Sterically encumbered/constrained Lewis pairs cannot form acid–base adducts, but such ‘Frustrated Lewis Pairs’ (FLPs), with their unquenched electronic demands can be elegantly used to simultaneously react with a third species, resulting in unusual reactivity of small molecules. Such unusual reactions, explored only in the last few years, have found several applications, e.g., heterolytic splitting of H2, activation of small molecules (CO2, N2O, etc.). FLPs have opened new opportunities in synthetic chemistry, covering organic, main group as well as transition metal chemistry. The design strategies adopted for FLP systems and their unique reactivity are discussed here.

  1. Socio-Statistical Research on the Internalization of European Administrative Space Principles in the Romanian Public Administration

    Directory of Open Access Journals (Sweden)

    Diana-Camelia Iancu

    2011-12-01

    Full Text Available The authors propose an analysis of the public administration reform in Romania by assessing whether the Romanian civil servants perform their duties according to the regulations of the European Administrative Space. The paper offers a socio-statistic perspective on the internalization of the European Administrative Space principles, namely, the rule of law, openness towards citizens, and public administration responsibility in a Romanian context, after the European Union accession. Designed within the framework of modern theories of organizational sociology that see internalization as a process of organizational learning and change, and using a relevant sample of Romanian civil servants, the paper offers important and useful results for the future Romanian policies and strategies in an integrated European arena.

  2. Building research administration applications for the academic health center: a case study.

    Science.gov (United States)

    Guard, J Roger; Brueggemann, Ralph F; Highsmith, Robert F; Marine, Stephen A; Riep, Josette R; Schick, Leslie C

    2005-11-01

    The academic health center information environment is saturated with information of varying quality and overwhelming quantity. The most significant challenge is transforming data and information into knowledge. The University of Cincinnati Medical Center's (UCMC) focus is to develop an information architecture comprising data structures, Web services, and user interfaces that enable individuals to manage the information overload so that they can create new knowledge. UCMC has accomplished much of what is reported in this article with the help of a four-year Integrated Advanced Information Management Systems (IAIMS) operation grant awarded by the National Library of Medicine in 2003. In the UCMC vision for knowledge management, individuals have reliable, secure access to information that is filtered, organized, and highly relevant for specific tasks and personal needs. Current applications and tool sets will evolve to become the next generation knowledge management applications or smart digital services. When smart digital services are implemented, silo applications will disappear. A major focus of UCMC's IAIMS grant is research administration. Testing and building out existing and new research administration applications and digital services is underway. The authors review UCMC's progress and results in developing a software architecture, tools, and services for research administration. Included are sections on the evolution to full integration, the impact of the work at UCMC to date, lessons learned during this research and development process, and future plans and needs.

  3. Modifications to Ivor Lewis esophagectomy.

    Science.gov (United States)

    David, Elizabeth A; Marshall, M Blair

    2010-11-01

    The surgical approach to esophagectomy is variable. A number of factors are considered when determining the optimal approach to esophagectomy: location and extent of disease, fibrosis, additional patient factors and surgeon preference. One of the disadvantages to some approaches is the need for a change in position, which increases operative time. Also, because typically the abdomen is initially explored, patients may later be deemed unresectable at thoracotomy. We describe time saving modifications to the standard Ivor Lewis esophagectomy that eliminate the need for repositioning and facilitate a stapled end-to-end anastomosis.

  4. The development of Lewis Henry Morgan's evolutionism.

    Science.gov (United States)

    Kuper, A

    1985-01-01

    Lewis Henry Morgan never used the term evolution in any of his major sociological works. If he may be labeled an evolutionist, the specificity of his views must be taken into account. The main "evolutionist" issue that concerned him was that of the unity or diversity of the human species. This was an urgent political and theological issue in the America of his day, and it impinged also on research on the American Indians. Morgan's first major study was designed to demonstrate the unity of origin of the American aborigines and their "Asian" origins. His methods were derived from the tradition of Indo-European philology. It was virtually as an afterthought that he added a social evolutionary component to what he conceived of as an exercise in philology. Later he came under the direct influence of the English evolutionists, and this was crucial for the conception of Ancient Society.

  5. NASA Lewis Meshed VSAT Workshop meeting summary

    Science.gov (United States)

    Ivancic, William

    1993-11-01

    NASA Lewis Research Center's Space Electronics Division (SED) hosted a workshop to address specific topics related to future meshed very small-aperture terminal (VSAT) satellite communications networks. The ideas generated by this workshop will help to identify potential markets and focus technology development within the commercial satellite communications industry and NASA. The workshop resulted in recommendations concerning these principal points of interest: the window of opportunity for a meshed VSAT system; system availability; ground terminal antenna sizes; recommended multifrequency for time division multiple access (TDMA) uplink; a packet switch design concept for narrowband; and fault tolerance design concepts. This report presents a summary of group presentations and discussion associated with the technological, economic, and operational issues of meshed VSAT architectures that utilize processing satellites.

  6. The use of research questionnaires with hearing impaired adults: online vs. paper-and-pencil administration

    Science.gov (United States)

    2012-01-01

    Background When evaluating hearing rehabilitation, it is reasonable to use self-report questionnaires as outcome measure. Questionnaires used in audiological research are developed and validated for the paper-and-pencil format. As computer and Internet use is increasing, standardized questionnaires used in the audiological context should be evaluated to determine the viability of the online administration format. The aim of this study was to compare administration of questionnaires online versus paper- and pencil of four standardised questionnaires used in hearing research and clinic. We included the Hearing Handicap Inventory for the Elderly (HHIE), the International Outcome Inventory for Hearing Aids (IOI-HA), Satisfaction with Amplification in Daily Life (SADL), and the Hospital Anxiety and Depression Scale (HADS). Methods A cross-over design was used by randomly letting the participants complete the questionnaires either online or on paper. After 3 weeks the participants filled out the same questionnaires again but in the other format. A total of 65 hearing-aid users were recruited from a hearing clinic to participate on a voluntary basis and of these 53 completed both versions of the questionnaires. Results A significant main effect of format was found on the HHIE (p questionnaires were no significant main or interaction effects of format. Significant correlations between the two ways of presenting the measures was found for all questionnaires (pquestionnaires and differences in Cronbachs α between administration formats were negligible. Conclusions For three of the four included questionnaires the participants’ scores remained consistent across administrations and formats. For the fourth included questionnaire (HHIE) a significant difference of format with a small effect size was found. The relevance of the difference in scores between the formats depends on which context the questionnaire is used in. On balance, it is recommended that the administration

  7. Drawing Lewis Structures without Anticipating Octets.

    Science.gov (United States)

    Carroll, James Allen

    1986-01-01

    After noting the grounds for labelling structures as incorrect, the guidelines for selecting which Lewis structures are most important for a molecule are introduced. Several examples of appropriate Lewis structures and the fine structural predictions that are possible are included. (JN)

  8. Deregulation Impact in Negotiating a New Electrical Contract Between NASA Glenn Research Center at Lewis Field and FirstEnergy Corp., Cleveland, Ohio, USA

    Science.gov (United States)

    Quach, Quyen T.; Zala, Laszlo F.

    2002-01-01

    The governor of the State of Ohio signed amended substitute Senate bill 3 on July 6, 1999, requiring Ohio's electric industry to change from a monopoly environment to a competitive electric environment for generation services. The start date for competitive retail generation services was set for January 1, 2001. This new deregulation law allowed all Ohioans to choose the supplier of generation service, but the transmission and distribution would remain regulated. It also required electric utilities to unbundle the three main components (generation, transmission, and distribution) and make other changes designed to produce a competitive electric generation market. While deregulation was taking shape, the NASA Glenn Research Center electrical contract with FirstEnergy Corp. of Cleveland, Ohio, was to expire on September 7, 1999. Glenn strategically evaluated and incorporated the impacts of electric deregulation in the negotiations. Glenn and FirstEnergy spent over a year in negotiations until the Glenn utility team and the FirstEnergy negotiating team came to an agreement in the fall of 2000, and a new contract became effective on January 1, 2001.

  9. A Practical, Global Perspective on Using Administrative Data to Conduct Intensive Care Unit Research.

    Science.gov (United States)

    Garland, Allan; Gershengorn, Hayley B; Marrie, Ruth Ann; Reider, Nadia; Wilcox, M Elizabeth

    2015-09-01

    Various data sources can be used to conduct research on critical illness and intensive care unit (ICU) use. Most published studies derive from randomized controlled trials, large-scale clinical databases, or retrospective chart reviews. However, few investigators have access to such data sources or possess the resources to create them. Hospital administrative data, also called health claims data, constitute an important alternative data source that can be used to address a broad range of research questions, including many that would be difficult to study in interventional studies. Such data often contain information that allows identification of ICU care, specific types of critical illness, and ICU-related procedures. The strengths of using administrative databases are that many are population-based, cover broad geographic regions, and are large enough to provide high statistical power and precise effect estimates. Linking hospital data to other databases regarding chronic care facilities, home care services, or rehabilitation services, for example, can expand the scope of research questions that can be answered. However, the limitations of administrative data must be recognized. They are not collected for research purposes; thus, data elements may vary in accuracy, and key clinical variables such as ICU-specific physiologic and laboratory data are usually lacking. Specific efforts should be made to validate the data elements used, as has been done in several world regions. As with any other research question, it is imperative that the analysis plan be carefully defined in advance and that appropriate attention be paid to potential sources of bias and confounding.

  10. On the concept of frustrated Lewis pairs.

    Science.gov (United States)

    Fontaine, Frédéric-Georges; Stephan, Douglas W

    2017-08-28

    In this concept article, we consider the notion of 'frustrated Lewis pairs' (FLPs). While the original use of the term referred to steric inhibition of dative bond formation in a Lewis pair, work in the intervening decade demonstrates the limitation of this simplistic view. Analogies to known transition metal chemistry and the applications in other areas of chemistry are considered. In the light of these findings, we present reflections on the criteria for a definition of the term 'frustrated Lewis pair'. Segregation of the Lewis acid and base and the kinetic nature of FLP reactivity are discussed. We are led to the conclusion that, while an all-inclusive definition of FLP is challenging, the notion of 'FLP chemistry' is more readily recognized.This article is part of the themed issue 'Frustrated Lewis pair chemistry'. © 2017 The Author(s).

  11. Administrative and research policies required to bring cellular therapies from the research laboratory to the patient's bedside.

    Science.gov (United States)

    Yim, Robyn

    2005-10-01

    presidential administrations on cellular therapy, variations in individual state laws, and states becoming involved in research funding, such as California's Proposition 71. Legal concerns include expanding private litigation with diversity of lawsuits, expanding lists of defendants, and the use of class-action lawsuits in research cases. Ownership issues also arise in terms of intellectual property, patents, and ownership of stem cells collected from minors, as in umbilical cord blood donations. Situations that challenge the regulatory processes established to ensure participant safety include differences in reporting requirements for private- and public-funded research and the lack of adequate funding and resources to implement and support the institutional review board (IRB) process. Financial considerations influence the development of clinical protocols, because funding is often limited. Financial incentives, personal investment in companies funding research activities, and fundraising pressures may present potential conflicts. In addition, the increasing role of emerging biotechnology start-up companies and pharmaceutical companies in clinical research introduces additional financial considerations. Administrative policies are needed to address these possible conflicts and ensure research participant safety as cellular therapies progress from the research laboratories to the patient's bedside. Administrative policies to ensure minimum standards of quality for emerging products before human clinical trials, policies to enforce consistent reporting requirements for private and public cellular research, policies to minimize financial conflicts of interest, policies to strengthen implementation of the existing IRB process and to structure into the process a consistent, systematic review of these identified conflicts, and policies to limit private litigation will help to preserve the objectivity of the review process and ultimately increase participant safety.

  12. Quantification of Lewis acid induced Brønsted acidity of protogenic Lewis bases.

    Science.gov (United States)

    Lathem, A Paige; Heiden, Zachariah M

    2017-05-09

    Proton transfer promoted by the coordination of protogenic Lewis bases to a Lewis acid is a critical step in catalytic transformations. Although the acidification of water upon coordination to a Lewis acid has been known for decades, no attempts have been made to correlate the Brønsted acidity of the coordinated water molecule with Lewis acid strength. To probe this effect, the pKa's (estimated error of 1.3 pKa units) in acetonitrile of ten protogenic Lewis bases coordinated to seven Lewis acids containing Lewis acidities varying 70 kcal mol(-1), were computed. To quantify Lewis acid strength, the ability to transfer a hydride (hydride donor ability) from the respective main group hydride was used. Coordination of a Lewis acid to water increased the acidity of the bound water molecule between 20 and 50 pKa units. A linear correlation exhibiting a 2.6 pKa unit change of the Lewis acid-water adduct per ten kcal mol(-1) change in hydride donor ability of the respective main group hydride was obtained. For the ten protogenic Lewis bases studied, the coordinated protogenic Lewis bases were acidified between 10 and 50 pKa units. On average, a ten kcal mol(-1) change in hydride donor ability of the respective main group hydride resulted in about a 2.8 pKa unit change in the Brønsted acidity of the Lewis acid-Lewis base adducts. Since attempts to computationally investigate the pKa of main group dihydrogen complexes were unsuccessful, experimental determination of the first reported pKa of a main group dihydrogen complex is described. The pKa of H2-B(C6F5)3 was determined to be 5.8 ± 0.2 in acetonitrile.

  13. The use of research questionnaires with hearing impaired adults: online vs. paper-and-pencil administration

    Directory of Open Access Journals (Sweden)

    Thorén Elisabet

    2012-10-01

    Full Text Available Abstract Background When evaluating hearing rehabilitation, it is reasonable to use self-report questionnaires as outcome measure. Questionnaires used in audiological research are developed and validated for the paper-and-pencil format. As computer and Internet use is increasing, standardized questionnaires used in the audiological context should be evaluated to determine the viability of the online administration format. The aim of this study was to compare administration of questionnaires online versus paper- and pencil of four standardised questionnaires used in hearing research and clinic. We included the Hearing Handicap Inventory for the Elderly (HHIE, the International Outcome Inventory for Hearing Aids (IOI-HA, Satisfaction with Amplification in Daily Life (SADL, and the Hospital Anxiety and Depression Scale (HADS. Methods A cross-over design was used by randomly letting the participants complete the questionnaires either online or on paper. After 3 weeks the participants filled out the same questionnaires again but in the other format. A total of 65 hearing-aid users were recruited from a hearing clinic to participate on a voluntary basis and of these 53 completed both versions of the questionnaires. Results A significant main effect of format was found on the HHIE (p Conclusions For three of the four included questionnaires the participants’ scores remained consistent across administrations and formats. For the fourth included questionnaire (HHIE a significant difference of format with a small effect size was found. The relevance of the difference in scores between the formats depends on which context the questionnaire is used in. On balance, it is recommended that the administration format remain stable across assessment points.

  14. Overview of the Veterans Health Administration (VHA) Quality Enhancement Research Initiative (QUERI)

    Science.gov (United States)

    McQueen, Lynn; Mittman, Brian S.; Demakis, John G.

    2004-01-01

    The U.S. Veterans Health Administration (VHA)'s Quality Enhancement Research Initiative (QUERI) is an innovative integration of health services research, policy, and clinical care delivery designed to improve the quality, outcomes, and efficiency of VHA health care through the identification and implementation of evidence-based practices in routine care settings. A total of eight condition-specific QUERI centers are currently in operation, each pursuing an integrated portfolio of activities designed to identify and correct gaps in clinical quality and performance and to derive generalizable scientific knowledge regarding quality improvement processes and methods and their effectiveness. This overview article describes QUERI's mission, history, structure, and activities and provides a brief summary of key findings and impacts. PMID:15187071

  15. Linking the US transplant registry to administrative claims data: expanding the potential of transplant research.

    Science.gov (United States)

    Gilmore, Amanda S; Helderman, J Harold; Ricci, Jean-Francois; Ryskina, Kira L; Feng, Sandy; Kang, Ning; Legorreta, Antonio P

    2007-06-01

    In the United States, data on transplanted and waitlisted patients collected by the Organ Procurement and Transplantation Network (OPTN) have been widely used in transplantation research. Administrative claims data, collected by health plans for reimbursement purposes, are also commonly used in health-services research. This study linked OPTN and private payer claims data to assess the relationship between data elements common to both sources. All transplanted or waitlisted patients in the registry were considered for inclusion. A multistep match algorithm was employed to link OPTN and payer data from years 1995 to 2004. Variables common to both datasets that contained relevant information for similar time periods were compared. A total of 21,419 solid organ transplant recipients and 8808 waitlist patients were included in the final linked database. Organ type and demographic variable distributions in the linked dataset were similar to the overall OPTN database. Using claims as the reference group, sensitivity and specificity values were on average 0.72 and 0.69, respectively, and were highest for the indicators of immunosuppression use at discharge and follow-up. This comparison of payer data with information reported by transplant centers to the OPTN provides important insight into the value of both data sources. Using administrative claims to augment the registry data with utilization and cost information will be useful for evaluation of both economic and clinical endpoints in solid organ transplantation.

  16. Peripheral Lewy body pathology in Parkinson's disease and incidental Lewy body disease: four cases.

    Science.gov (United States)

    Del Tredici, Kelly; Duda, John E

    2011-11-15

    The accumulation of Lewy pathology (LP) within autonomic nervous system tissues has received increased attention recently as a possible induction site for Lewy neurodegeneration and a possible source of biopsy material for biomarkers of early Parkinson's disease (PD). Here, we describe LP accumulation within various tissues involving peripheral autonomic nervous system neurons in three PD cases and one case of incidental Lewy body disease. Findings highlight the value of examining pathology within functional neuroanatomical systems and particularly the importance of Lewy neurites (LNs) in the pathophysiology of PD.

  17. Abegg, Lewis, Langmuir, and the Octet Rule.

    Science.gov (United States)

    Jensen, William B.

    1984-01-01

    Discusses major events leading to the development of the octet rule. Three conclusions based on the work of Mendeleev, Abegg, Thompson, Kossel, Lewis, and Langmuir are considered as is the debate over the rule's validity. (JN)

  18. Health Economics Studies Information Exchange; Reports of Current Research in Health Economics, and Medical Care Administration. Publication No. 1719.

    Science.gov (United States)

    Public Health Service (DHEW), Arlington, VA. Home Economics Branch.

    The first volume of a continuing series reporting research in progress in health economics and medical care organization and administration was compiled by contacting (1) graduate schools offering degrees in the health professions, sociology, economics, public administration, and public health, (2) charitable foundations indicating an interest in…

  19. Neurophysiological biomarkers for Lewy body dementias

    OpenAIRE

    Cromarty, Ruth A.; Elder, Greg J.; Graziadio, Sara; Baker, Mark; Bonanni, Laura; Onofrj, Marco; O’Brien, John T.; Taylor, John-Paul

    2016-01-01

    Objective Lewy body dementias (LBD) include both dementia with Lewy bodies (DLB) and Parkinson’s disease with dementia (PDD), and the differentiation of LBD from other neurodegenerative dementias can be difficult. Currently, there are few biomarkers which might assist early diagnosis, map onto LBD symptom severity, and provide metrics of treatment response. Traditionally, biomarkers in LBD have focussed on neuroimaging modalities; however, as biomarkers need to be simple, inexpensive and non-...

  20. Educational Research within the Administration: A Booming Business in the French-Speaking Part of Switzerland (1950-1980)

    Science.gov (United States)

    Rothen, Christina

    2016-01-01

    This paper analyses the formation and development of educational research institutions within the educational administration using the example of four research institutions in the French-speaking part of Switzerland. The analysis gives insight into the institutionalisation process of education research outside the university with special focus on…

  1. JPART Virtual Issue on Citizen-State Interactions in Public Administration Research

    DEFF Research Database (Denmark)

    Jakobsen, Morten; James, Oliver; Moynihan, Donald P.;

    2016-01-01

    of these articles in particular. These eight articles are excellent examples of the potential added value of psychological insights to key public administration questions. We hope that this Virtual Issue inspires scholars and practitioners to deepen the dialogue between public administration and psychology.......For public administration scholars, psychological theories and methods can be extremely helpful, especially when studying attitudes or behaviors of (groups of) citizens, public professionals, or public managers. Behavioral public administration explicitly connects public administration...

  2. Proposal for a European Public Health Research Infrastructure for Sharing of health and Medical administrative data (PHRIMA).

    Science.gov (United States)

    Burgun, Anita; Oksen, Dina V; Kuchinke, Wolfgang; Prokosch, Hans-Ulrich; Ganslandt, Thomas; Buchan, Iain; van Staa, Tjeerd; Cunningham, James; Gjerstorff, Marianne L; Dufour, Jean-Charles; Gibrat, Jean-Francois; Nikolski, Macha; Verger, Pierre; Cambon-Thomsen, Anne; Masella, Cristina; Lettieri, Emanuele; Bertele, Paolo; Salokannel, Marjut; Thiebaut, Rodolphe; Persoz, Charles; Chêne, Geneviève; Ohmann, Christian

    2015-01-01

    In Europe, health and medical administrative data is increasingly accumulating on a national level. Looking further than re-use of this data on a national level, sharing health and medical administrative data would enable large-scale analyses and European-level public health projects. There is currently no research infrastructure for this type of sharing. The PHRIMA consortium proposes to realise the Public Health Research Infrastructure for Sharing of health and Medical Administrative data (PHRIMA) which will enable and facilitate the efficient and secure sharing of healthcare data.

  3. Slovene critics on Sinclair Lewis's novels

    Directory of Open Access Journals (Sweden)

    Vanja Avsenak

    2010-12-01

    Full Text Available The purpose of this article is to present the reception of Sinclair Lewis's novels by Slovene critics. Initially, the article focuses on the life and workof Sinclair Lewis, giving special emphasis to social influences that made the author a representative figure in the literary and social world. Thus his works are nowadays to be understood primarily as fiction, but on the other hand also as sociological documents of a social and political situation of the period between the two world wars. Generally, the effect they produce is one of a critical discussion of the nation of the United States. When speaking of the social relevance that Lewis's novels have, it is obvious that his works are the portrayals of Americans and their deficiencies. At the time of their publication Lewis's novels received unfavourable criticism on accountof his overly open pro-European attitude and Slovene critics of the period before World War II emphasise this in much detail. It was precisely this anti-American propaganda in the novels themselves and sincerity on the part of the novelist that won the European critics as well as the readers whenit came to appreciating his works. However, Lewis's view of the Americans, as presented throughout his works, only enhanced his literary credibility as a modern writer. That is why the articles by Slovene critics that appeared after the Second World War, and even more significantly after Lewis's death, almost minutely reflect a more favourable attitude to Sinclair Lewis, which was also the case with foreign literary criticism of the post-war period. Critics still discuss the qualities and flaws of Lewis's novels, but being more lenient they no longer profess that the novels lack in artistic value. They remain, however, primarily relevant as social documents of the pre- and post-war era, which fully presented the American middle-class mentality in America and elsewhere. For this reason, the Nobel Prize for Literature awarded to

  4. Diagnosis and management of dementia with Lewy bodies

    Science.gov (United States)

    Boeve, Bradley F.; Dickson, Dennis W.; Halliday, Glenda; Taylor, John-Paul; Weintraub, Daniel; Aarsland, Dag; Galvin, James; Attems, Johannes; Ballard, Clive G.; Bayston, Ashley; Beach, Thomas G.; Blanc, Frédéric; Bohnen, Nicolaas; Bonanni, Laura; Bras, Jose; Brundin, Patrik; Burn, David; Chen-Plotkin, Alice; Duda, John E.; El-Agnaf, Omar; Feldman, Howard; Ferman, Tanis J.; ffytche, Dominic; Fujishiro, Hiroshige; Galasko, Douglas; Goldman, Jennifer G.; Gomperts, Stephen N.; Graff-Radford, Neill R.; Honig, Lawrence S.; Iranzo, Alex; Kantarci, Kejal; Kaufer, Daniel; Kukull, Walter; Lee, Virginia M.Y.; Leverenz, James B.; Lewis, Simon; Lippa, Carol; Lunde, Angela; Masellis, Mario; Masliah, Eliezer; McLean, Pamela; Mollenhauer, Brit; Montine, Thomas J.; Moreno, Emilio; Mori, Etsuro; Murray, Melissa; O'Brien, John T.; Orimo, Sotoshi; Postuma, Ronald B.; Ramaswamy, Shankar; Ross, Owen A.; Salmon, David P.; Singleton, Andrew; Taylor, Angela; Thomas, Alan; Tiraboschi, Pietro; Toledo, Jon B.; Trojanowski, John Q.; Tsuang, Debby; Walker, Zuzana; Yamada, Masahito; Kosaka, Kenji

    2017-01-01

    The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade. The revised DLB consensus criteria now distinguish clearly between clinical features and diagnostic biomarkers, and give guidance about optimal methods to establish and interpret these. Substantial new information has been incorporated about previously reported aspects of DLB, with increased diagnostic weighting given to REM sleep behavior disorder and 123iodine-metaiodobenzylguanidine (MIBG) myocardial scintigraphy. The diagnostic role of other neuroimaging, electrophysiologic, and laboratory investigations is also described. Minor modifications to pathologic methods and criteria are recommended to take account of Alzheimer disease neuropathologic change, to add previously omitted Lewy-related pathology categories, and to include assessments for substantia nigra neuronal loss. Recommendations about clinical management are largely based upon expert opinion since randomized controlled trials in DLB are few. Substantial progress has been made since the previous report in the detection and recognition of DLB as a common and important clinical disorder. During that period it has been incorporated into DSM-5, as major neurocognitive disorder with Lewy bodies. There remains a pressing need to understand the underlying neurobiology and pathophysiology of DLB, to develop and deliver clinical trials with both symptomatic and disease-modifying agents, and to help patients and carers worldwide to inform themselves about the disease, its prognosis, best available treatments, ongoing research, and how to get adequate support. PMID:28592453

  5. A Health Services Research Agenda for Bariatric Surgery Within the Veterans Health Administration.

    Science.gov (United States)

    Funk, L M; Gunnar, W; Dominitz, J A; Eisenberg, D; Frayne, S; Maggard-Gibbons, M; Kalarchian, M A; Livingston, E; Sanchez, V; Smith, B R; Weidenbacher, H; Maciejewski, Matthew L

    2017-04-01

    In 2016, the Veterans Health Administration (VHA) held a Weight Management State of the Art conference to identify evidence gaps and develop a research agenda for population-based weight management for veterans. Included were behavioral, pharmacologic, and bariatric surgery workgroups. This article summarizes the bariatric surgery workgroup (BSWG) findings and recommendations for future research. The BSWG agreed that there is evidence from randomized trials and large observational studies suggesting that bariatric surgery is superior to medical therapy for short- and intermediate-term remission of type 2 diabetes, long-term weight loss, and long-term survival. Priority evidence gaps include long-term comorbidity remission, mental health, substance abuse, and health care costs. Evidence of the role of endoscopic weight loss options is also lacking. The BSWG also noted the limited evidence regarding optimal timing for bariatric surgery referral, barriers to bariatric surgery itself, and management of high-risk bariatric surgery patients. Clinical trials of pre- and post-surgery interventions may help to optimize patient outcomes. A registry of overweight and obese veterans and a workforce assessment to determine the VHA's capacity to increase bariatric surgery access were recommended. These will help inform policy modifications and focus the research agenda to improve the ability of the VHA to deliver population-based weight management.

  6. Main Group Lewis Acid-Mediated Transformations of Transition-Metal Hydride Complexes.

    Science.gov (United States)

    Maity, Ayan; Teets, Thomas S

    2016-08-10

    This Review highlights stoichiometric reactions and elementary steps of catalytic reactions involving cooperative participation of transition-metal hydrides and main group Lewis acids. Included are reactions where the transition-metal hydride acts as a reactant as well as transformations that form the metal hydride as a product. This Review is divided by reaction type, illustrating the diverse roles that Lewis acids can play in mediating transformations involving transition-metal hydrides as either reactants or products. We begin with a discussion of reactions where metal hydrides form direct adducts with Lewis acids, elaborating the structure and dynamics of the products of these reactions. The bulk of this Review focuses on reactions where the transition metal and Lewis acid act in cooperation, and includes sections on carbonyl reduction, H2 activation, and hydride elimination reactions, all of which can be promoted by Lewis acids. Also included is a section on Lewis acid-base secondary coordination sphere interactions, which can influence the reactivity of hydrides. Work from the past 50 years is included, but the majority of this Review focuses on research from the past decade, with the intent of showcasing the rapid emergence of this field and the potential for further development into the future.

  7. Ferrocene-based Lewis acids and Lewis pairs: Synthesis and structural characterization

    Indian Academy of Sciences (India)

    Pagidi Sudhakar; Pakkirisamy Thilagar

    2013-01-01

    Optically active Lewis acids and Lewis pairs were synthesized and characterized by multinuclear NMR, UV/Vis spectroscopy and elemental analysis. Optical rotation measurements were carried out and the absolute configuration of the new chiral molecules confirmed by single crystal X-ray diffraction.

  8. Scales of Lewis basicities toward C-centered Lewis acids (carbocations).

    Science.gov (United States)

    Mayr, Herbert; Ammer, Johannes; Baidya, Mahiuddin; Maji, Biplab; Nigst, Tobias A; Ofial, Armin R; Singer, Thomas

    2015-02-25

    Equilibria for the reactions of benzhydryl cations (Ar2CH(+)) with phosphines, tert-amines, pyridines, and related Lewis bases were determined photometrically in CH2Cl2 and CH3CN solution at 20 °C. The measured equilibrium constants can be expressed by the sum of two parameters, defined as the Lewis Acidity (LA) of the benzhydrylium ions and the Lewis basicity (LB) of the phosphines, pyridines, etc. Least-squares minimization of log K = LA + LB with the definition LA = 0 for (4-MeOC6H4)2CH(+) gave a Lewis acidity scale for 18 benzhydrylium ions covering 18 orders of magnitude in CH2Cl2 as well as Lewis basicities (with respect to C-centered Lewis acids) for 56 bases. The Lewis acidities correlated linearly with the quantum chemically calculated (B3LYP/6-311++G(3df,2pd)//B3LYP/6-31G(d,p) level) methyl anion affinities of the corresponding benzhydrylium ions, which can be used as reference compounds for characterizing a wide variety of Lewis bases. The equilibrium measurements were complemented by isothermal titration calorimetry studies. Rates of SN1 solvolyses of benzhydryl chlorides, bromides, and tosylates derived from E(13-33)(+), i.e., from highly reactive carbocations, correlate excellently with the corresponding Lewis acidities and the quantum chemically calculated methyl anion affinities. This correlation does not hold for solvolyses of derivatives of the better stabilized amino-substituted benzhydrylium ions E(1-12)(+). In contrast, the correlation between electrophilic reactivities and Lewis acidities (or methyl anion affinities) is linear for all donor-substituted benzhydrylium ions E(1-21)(+), while the acceptor-substituted benzhydrylium ions E(26-33)(+) react more slowly than expected from their thermodynamic stabilities. The boundaries of linear rate-equilibrium relationships were thus defined.

  9. Experimental Research on Inhabitation Effect of Hedyotis Diffusa Willd on Lewis Lung Canser Spontaneous Metastasis in Mouse%白花蛇舌草抑制Lewis肺癌小鼠自发转移的实验研究

    Institute of Scientific and Technical Information of China (English)

    李洁; 李玉基; 李博

    2012-01-01

    Objective: To observe the effect of Hedyotis diffusa on inhibiting Lewis lung spontaneous metastasis in mouse. Methods: To establish the spontaneous metastasis model with subcutaneous injection Lewis lung cancer tumor cell suspension into the C57BL mouse through right axillaries and observe the changes of mouse's weight, solid tumor growth, lung metastasis, and immune organ index. Results: For the mice in Hedyotis diffusa role groups, the quality of mice' life obviously improved; the index of immune organs and the tumor inhibition rate were increased significantly, pulmonary metastasis nodules was significantly reduced compared with the blank group. Conclusion: Hedyotis diffusa has an inhibitory effect on Lewis lung cancer spontaneous metastasis.%目的:观察白花蛇舌草对Lewis肺癌小鼠自发转移的影响.方法:在C57BL小鼠右侧腋下皮下注射接种肺癌Lewis瘤细胞悬液,复制自发转移模型,观察小鼠体重变化、实体瘤生长情况、肺转移瘤生长情况、免疫器官指数等指标变化.结果:白花蛇舌草作用组的小鼠,小鼠生活质量得到明显改善,免疫器官指数、抑瘤率明显增加,肺部转移结节数较空白组明显减少.结论:白花蛇舌草可抑制Lewis肺癌小鼠自发转移.

  10. Quantitative Research Methods Training in Education Leadership and Administration Preparation Programs as Disciplined Inquiry for Building School Improvement Capacity

    Science.gov (United States)

    Bowers, Alex J.

    2017-01-01

    The quantitative research methods course is a staple of graduate programs in education leadership and administration. Historically, these courses serve to train aspiring district and school leaders in fundamental statistical research topics. This article argues for programs to focus as well in these courses on helping aspiring leaders develop…

  11. Research Management and Administration: A Reflection of Where We Are and Where We Need to Go as a Profession

    Science.gov (United States)

    Langley, David

    2012-01-01

    In this article, the author reflects on research management and administration (RMA) as a profession. RMA arose from the need to manage growth in the number and complexity of research awards over the last fifty years, and is an activity and profession that continues to mature. It has grown in parallel with the increasing complexity of research…

  12. Prohibition and regulatory authority: a documental research about drugs categorizing administrative process

    Directory of Open Access Journals (Sweden)

    Milena Karla Soares

    2016-09-01

    Full Text Available This work aims to map the decision making process and identify actors and foundation of regulatory normative acts within public policy about drugs, consubstantiated with the edition and updates of Portaria SVS/MS nº 344/1998, which defines rules to substances under special control and forbidden substances in Brazil, and complement the meaning of Law 11.343/2006. A documentary research was made to elucidate the following issues: compliance of the acts of National Agency for Sanitary Vigilance - ANVISA to the actualizations of the lists of the international conventions about the theme; actors who have initiative of the inclusion process of substances; steps of the process; use of social participation, decisional transparency and accountability mechanisms; consulted sources to subsidize the decision and main reasons related in the technical reports. The results shows that there’s not total compliance to the international parameters with the inclusion of substances in the Brazilian controlling lists and that the prohibition is more related to public security reasons than health damages, probably due to asymmetric influence of interest groups in the administrative process.

  13. Complexation of Nitrous Oxide by Frustrated Lewis Pairs

    NARCIS (Netherlands)

    Otten, Edwin; Neu, Rebecca C.; Stephan, Douglas W.

    2009-01-01

    Frustrated Lewis pairs comprised of a basic yet sterically encumbered phosphine with boron Lewis acids bind nitrous oxide to give intact PNNOB linkages. The synthesis, structure, and bonding of these species are described.

  14. Neuroimaging characteristics of dementia with Lewy bodies.

    Science.gov (United States)

    Mak, Elijah; Su, Li; Williams, Guy B; O'Brien, John T

    2014-01-01

    This review summarises the findings and applications from neuroimaging studies in dementia with Lewy bodies (DLB), highlighting key differences between DLB and other subtypes of dementia. We also discuss the increasingly important role of imaging biomarkers in differential diagnosis and outline promising areas for future research in DLB. DLB shares common clinical, neuropsychological and pathological features with Parkinson's disease dementia and other dementia subtypes, such as Alzheimer's disease. Despite the development of consensus diagnostic criteria, the sensitivity for differential diagnosis of DLB in clinical practice remains low and many DLB patients will be misdiagnosed. The importance of developing accurate imaging markers in dementia is highlighted by the potential for treatments targeting specific molecular abnormalities as well as the responsiveness to cholinesterase inhibitors and marked neuroleptic sensitivity of DLB. We review various brain imaging techniques that have been applied to investigate DLB, including the characteristic nigrostriatal degeneration in DLB using positron emission tomography (PET) and single-photon emission computed tomography (SPECT) tracers. Dopamine transporter loss has proven to reliably differentiate DLB from other dementias and has been incorporated into the revised clinical diagnostic criteria for DLB. To date, this remains the 'gold standard' for diagnostic imaging of DLB. Regional cerebral blood flow, 18 F-fluorodeoxygluclose-PET and SPECT have also identified marked deficits in the occipital regions with relative sparing of the medial temporal lobe when compared to Alzheimer's disease. In addition, structural, diffusion, and functional magnetic resonance imaging techniques have shown alterations in structure, white matter integrity, and functional activity in DLB. We argue that the multimodal identification of DLB-specific biomarkers has the potential to improve ante-mortem diagnosis and contribute to our

  15. Toward an Ontology of Practices in Educational Administration: Theoretical Implications for Research and Practice

    Science.gov (United States)

    Newton, Paul; Riveros, Augusto

    2015-01-01

    In this article, we argue for a study of educational administration centered on an "ontology of practices." This is an initial proposal for thinking about and conceptualizing practices in educational administration. To do this, first, we explore how practices are constituted and how they configure the social realities of practitioners.…

  16. Toward an Ontology of Practices in Educational Administration: Theoretical Implications for Research and Practice

    Science.gov (United States)

    Newton, Paul; Riveros, Augusto

    2015-01-01

    In this article, we argue for a study of educational administration centered on an "ontology of practices." This is an initial proposal for thinking about and conceptualizing practices in educational administration. To do this, first, we explore how practices are constituted and how they configure the social realities of practitioners.…

  17. Gender Imbalance in Higher Education: Insights for College Administrators and Researchers

    Science.gov (United States)

    Conger, Dylan; Dickson, Lisa

    2017-01-01

    University administrators often strive for racial, socioeconomic, and geographic diversity in their student populations. Today, administrators face a new demographic challenge as women increasingly outnumber men in applications, enrollments, and graduation rates. This article discusses the causes and potential consequences of the growing gender…

  18. Teaching Beginning Chemistry Students Simple Lewis Dot Structures

    Science.gov (United States)

    Nassiff, Peter; Czerwinski, Wendy A.

    2015-01-01

    Students beginning their initial study of chemistry often have a difficult time mastering simple Lewis dot structures. Textbooks show students how to manipulate Lewis structures by moving valence electron dots around the chemical structure so each atom has an octet or duet. However, an easier method of teaching Lewis structures for simple…

  19. Metal-free electrocatalytic hydrogen oxidation using frustrated Lewis pairs and carbon-based Lewis acids.

    Science.gov (United States)

    Lawrence, Elliot J; Clark, Ewan R; Curless, Liam D; Courtney, James M; Blagg, Robin J; Ingleson, Michael J; Wildgoose, Gregory G

    2016-04-21

    Whilst hydrogen is a potentially clean fuel for energy storage and utilisation technologies, its conversion to electricity comes at a high energetic cost. This demands the use of rare and expensive precious metal electrocatalysts. Electrochemical-frustrated Lewis pairs offer a metal-free, CO tolerant pathway to the electrocatalysis of hydrogen oxidation. They function by combining the hydrogen-activating ability of frustrated Lewis pairs (FLPs) with electrochemical oxidation of the resultant hydride. Here we present an electrochemical-FLP approach that utilises two different Lewis acids - a carbon-based N-methylacridinium cation that possesses excellent electrochemical attributes, and a borane that exhibits fast hydrogen cleavage kinetics and functions as a "hydride shuttle". This synergistic interaction provides a system that is electrocatalytic with respect to the carbon-based Lewis acid, decreases the required potential for hydrogen oxidation by 1 V, and can be recycled multiple times.

  20. Lewis Mumford and the Ecology of Technics.

    Science.gov (United States)

    Strate, Lance; Lum, Casey Man Kong

    2000-01-01

    Examines Lewis Mumford's scholarship and his contribution to the emergence of media ecology as both an intellectual tradition and a theoretical perspective on the study of technology, media, and culture. Focuses on Mumford's epochal historiography of technology, the techno-organicism in his thinking about technology and human development, and his…

  1. Renal Failure in Dementia with Lewy Bodies Presenting as Catatonia

    Directory of Open Access Journals (Sweden)

    Robert Fekete

    2013-01-01

    Full Text Available Catatonia, originally described by Karl Kahlbaum in 1874, may be regarded as a set of clinical features found in a subtype of schizophrenia, but the syndrome may also stem from organic causes including vascular parkinsonism, brain masses, globus pallidus lesions, metabolic derangements, and pharmacologic agents, especially first generation antipsychotics. Catatonia may include paratonia, waxy flexibility (cerea flexibilitas, stupor, mutism, echolalia, and catalepsy (abnormal posturing. A case of catatonia as a result of acute renal failure in a patient with dementia with Lewy bodies is described. This patient recovered after intravenous fluid administration and reinstitution of the atypical dopamine receptor blocking agent quetiapine, but benzodiazepines and amantadine are additional possible treatments. Recognition of organic causes of catatonia leads to timely treatment and resolution of the syndrome.

  2. Initial results from the Solar Dynamic (SD) Ground Test Demonstration (GTD) project at NASA Lewis

    Science.gov (United States)

    Shaltens, Richard K.; Boyle, Robert V.

    1995-01-01

    A government/industry team designed, built, and tested a 2 kWe solar dynamic space power system in a large thermal/vacuum facility with a simulated sun at the NASA Lewis Research Center. The Lewis facility provides an accurate simulation of temperatures, high vacuum, and solar flux as encountered in low earth orbit. This paper reviews the goals and status of the Solar Dynamic (SD) Ground Test Demonstration (GTD) program and describes the initial testing, including both operational and performance data. This SD technology has the potential as a future power source for the International Space Station Alpha.

  3. Tribute to Erwin Felix Lewy-Bertaut; Hommage a Erwin Felix Lewy-Bertaut

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    Erwin Lewy (alias Felix Bertaut) was born in 1913 in Germany, he emigrated to France where he undertook graduate studies in chemistry. Then, he joined the powder central laboratory where he learnt how to use international tables for structure determination. His thesis work was the X-ray study of the statistical distribution of the size of iron grains. The method Bertaut developed is still a reference in powder granulometry. Bertaut was also interested in the nascent neutron diffraction method and he flew to the United-States to improve his knowledge on this topic. Felix Bertaut created the neutron diffraction laboratory in the atomic research center in Grenoble and later he headed the CNRS' crystallography laboratory till 1982. Felix Bertaut and his laboratories became internationally renowned in crystallography, neutron diffraction and magnetism. He favored the scientific cooperation between France and Germany that led to the creation of the Laue-Langevin Institute (ILL). The ILL became European and was a key partner for building the European Synchrotron Facility (ESRF) in Grenoble. Bertaut was elected as a full member of the French Academy of Sciences in 1979, he died in 2003. (A.C.)

  4. Lewis Carroll, a educação e o ensino de geometria na Inglaterra vitoriana - Lewis Carroll, education and the teaching of geometry in victorian England

    Directory of Open Access Journals (Sweden)

    Rafael Montoito

    2015-04-01

    Full Text Available Parte da pesquisa motivada pela tradução para o português do livro Euclides e seus rivais modernos, publicado por Lewis Carroll em 1879, este artigo se inscreve numa série de estudos que visam a um exame hermenêutico dessa obra. São discutidos temas relacionados com a educação, a educação matemática e o ensino de geometria na Inglaterra vitoriana.Palavras-chave: Lewis Carroll, Euclides e seus rivais modernos, história da educação, educação matemática, geometria. LEWIS CARROLL, EDUCATION AND THE TEACHING OF GEOMETRY IN VICTORIAN ENGLANDAbstractResearch partly motivated by Lewis Carrroll's Euclid and his modern rivals (1879 portuguese translation, this paper presents some hermeneutical remarks taken as necessary to understand the context in which such book was produced. The paper focuses particularly on education, in general, and on the teaching of mathematics and geometry in victorian England.Key-words: Lewis Carroll, Euclid and his modern rivals, history of education, mathematics education, geometry. LEWIS CARROLL, LA EDUCACIÓN Y EL ENSINO DE GEOMETRÍA EN LA INGLATERRA VICTORIANAResumenParte de la investigación motivada por la traducción al portugués del libro Euclides y sus enemigos modernos, publicado por Lewis Carroll en 1879, este artículo se inscribe en una serie de estudios que tienen por objetivo hacer un examen hermenéutico de la obra. Son aquí discutidos temas relacionados como la educación, la educación matemática y la enseñanza de geometría en la Inglaterra victoriana.Palabras-clave: Lewis Carroll, Euclides y sus enemigos modernos, historia de la educación, educación matemática, geometría. LEWIS CARROLL, L’ÉDUCATION ET L’ENSEIGMENT DE GÉOMÉTRIE EN L’ANGLETERRE VICTORIENNERésuméFaisant partie de la recherche motivée par la traduction en portugais du livre Euclide et ses rivaux modernes, publié par Lewis Carrol en 1879 , cet article s’inscrit dans une série d’études dont le but

  5. Impact of Information and Communication Technologies on School Administration: Research on the Greek Schools of Secondary Education

    Science.gov (United States)

    Saiti, Anna; Prokopiadou, Georgia

    Information and Communication Technologies (ICT) may be considered as a synonym for the modernization of all organizations, including school units, as they provide for advanced and updated technological tools and applications. Nowadays, the implementation of new technologies in the schools of secondary education in Greece has been rapidly increasing. This adoption of ICT reinforces the teaching process, but also facilitates administrative transactions. The current research aims to determine the level of technological infrastructure present in the secondary schools of Greece, to what extent this equipment meets their administrative needs, to study the role of the school libraries in their contribution to the modernization of school administration, and to examine the conditions that influence the implementation of ICT in school management.

  6. Ermakov–Lewis invariants and Reid systems

    Energy Technology Data Exchange (ETDEWEB)

    Mancas, Stefan C., E-mail: stefan.mancas@erau.edu [Department of Mathematics, Embry-Riddle Aeronautical University, Daytona Beach, FL 32114-3900 (United States); Rosu, Haret C., E-mail: hcr@ipicyt.edu.mx [IPICyT, Instituto Potosino de Investigacion Cientifica y Tecnologica, Camino a la presa San José 2055, Col. Lomas 4a Sección, 78216 San Luis Potosí, S.L.P. (Mexico)

    2014-06-13

    Reid's mth-order generalized Ermakov systems of nonlinear coupling constant α are equivalent to an integrable Emden–Fowler equation. The standard Ermakov–Lewis invariant is discussed from this perspective, and a closed formula for the invariant is obtained for the higher-order Reid systems (m≥3). We also discuss the parametric solutions of these systems of equations through the integration of the Emden–Fowler equation and present an example of a dynamical system for which the invariant is equivalent to the total energy. - Highlights: • Reid systems of order m are connected to Emden–Fowler equations. • General expressions for the Ermakov–Lewis invariants both for m=2 and m≥3 are obtained. • Parametric solutions of the Emden–Fowler equations related to Reid systems are obtained.

  7. Rendezvous, un juego de Lewis Carroll

    Directory of Open Access Journals (Sweden)

    José Manuel Sánchez Muñoz

    2011-10-01

    Full Text Available Todos en mayor o menor medida asociamos el nombre de Lewis Carrolla la literatura, sobre todo a la de temática infantil, con títulos a sus espaldas como Alicia en el País de las Maravillas, Alicia a través del espejo, o La Caza del Snark. Pero además de literato, Lewis Carrol fue un hombre con bastantes inquietudes en torno a la matemática, la lógica y el pensamiento filosófico. Pero no todo el mundo es conocedor de su faceta como creativo en el campo de los juegos. Rendezvous es una de sus más sorprendentes invenciones,un juego de inteligencia para todos los públicos, cuyas directrices hacen de él un entretenimiento bastante original.

  8. Rendezvous, un juego de Lewis Carroll

    OpenAIRE

    José Manuel Sánchez Muñoz

    2011-01-01

    Todos en mayor o menor medida asociamos el nombre de Lewis Carrolla la literatura, sobre todo a la de temática infantil, con títulos a sus espaldas como Alicia en el País de las Maravillas, Alicia a través del espejo, o La Caza del Snark. Pero además de literato, Lewis Carrol fue un hombre con bastantes inquietudes en torno a la matemática, la lógica y el pensamiento filosófico. Pero no todo el mundo es conocedor de su faceta como creativo en el campo de los juegos. Rendezvous es una de sus más...

  9. Comparison of determinants of research knowledge utilization by practitioners and administrators in the field of child and family social services

    Directory of Open Access Journals (Sweden)

    Gervais Marie-Joëlle

    2010-06-01

    Full Text Available Abstract Background An important gap exists between research production and its utilization. Few studies have examined the factors affecting knowledge utilization in the field of child and family social services. Methods The objectives of the study are to describe knowledge utilization by child protection administrators and practitioners (N = 477 and to compare factors related to knowledge utilization by these two occupational groups. The study was conducted with an adapted version of the Questionnaire sur l'utilisation des connaissances (Knowledge Utilization Questionnaire. Factor analysis was used to collapse data collected on the questionnaire items. Factor score for each respondent served as independent variables in three separate multivariate regression analyses to explore variables likely to predict research-based knowledge utilization. Results A minority of respondents (18% report using on a frequent basis research-based knowledge in their practice. Relational capital between researchers and users and perceived usefulness of research based knowledge were the two factors most strongly related to utilization. There was a specificity in the factors associated with knowledge utilization according to occupational groups in child protection organizations. Use of active knowledge transfer strategies was associated with knowledge utilization by practitioners, while knowledge dissemination efforts played a more significant role for administrators. Conclusion These results encourage both the use of strategies differentiated according to users and the intensification of interactions between users and researchers to foster research knowledge utilization.

  10. The Critical Reception of Lewis Nordan

    DEFF Research Database (Denmark)

    Bjerre, Thomas Ærvold

    2010-01-01

    The essay covers the critical reception of Mississippi-writer Lewis Nordan from his debut in 1983 to the boost in scholarly attention in the new millennium. The essay covers newspaper reviews but pays particular attention to the many academic essays that have placed Nordan as a writer in the sout...... in the southern literary tradition and have highlighted themes such as magical realism, the grotesque, race relations, music, and gender....

  11. Dual Lewis Acid/Lewis Base Catalyzed Acylcyanation of Aldehydes: A Mechanistic Study.

    Science.gov (United States)

    Laurell Nash, Anna; Hertzberg, Robin; Wen, Ye-Qian; Dahlgren, Björn; Brinck, Tore; Moberg, Christina

    2016-03-07

    A mechanistic investigation, which included a Hammett correlation analysis, evaluation of the effect of variation of catalyst composition, and low-temperature NMR spectroscopy studies, of the Lewis acid-Lewis base catalyzed addition of acetyl cyanide to prochiral aldehydes provides support for a reaction route that involves Lewis base activation of the acyl cyanide with formation of a potent acylating agent and cyanide ion. The cyanide ion adds to the carbonyl group of the Lewis acid activated aldehyde. O-Acylation by the acylated Lewis base to form the final cyanohydrin ester occurs prior to decomplexation from titanium. For less reactive aldehydes, the addition of cyanide is the rate-determining step, whereas, for more reactive, electron-deficient aldehydes, cyanide addition is rapid and reversible and is followed by rate-limiting acylation. The resting state of the catalyst lies outside the catalytic cycle and is believed to be a monomeric titanium complex with two alcoholate ligands, which only slowly converts into the product. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Structuring the Administrative Organization of Local School Systems. Educational Research Service Circular No. 2.

    Science.gov (United States)

    American Association of School Administrators, Washington, DC.

    This paper is intended to assist school administrators in improving existing school organizations. It discusses the nature of organizations, provides indicators of reorganization timing, and discusses the task of reorganization. A matrix chart, used to analyze and compare different organizational structures, is provided with explanations.…

  13. Structured Observation of School Administrator Work Activities: Methodological Limitations and Recommendations for Research, Part 1.

    Science.gov (United States)

    Pitner, Nancy J.; Russell, James S.

    1986-01-01

    This paper critically reviews studies of administrator work activities which follow the work of Henry Mintzberg (1973), concentrating on these shortcomings of the method: (1) procedural difficulties in coding; (2) design limitations of classifying activities; (3) inadequate testing of Mintzberg's hypotheses; and (4) failure to explore antecedents…

  14. Developing Insight in Aspiring Researchers: Challenges Confronting Public Administration Teachers and Scholars

    Science.gov (United States)

    Jacobs, Richard M.

    2016-01-01

    A 2 × 2 matrix identifying four discrete thought processes was presented. The contributions of the first three processes in developing the knowledge base of public administration were detailed as were their limitations. It was argued that the fourth process--insight and its mental powers--builds upon the strengths and overcomes the limitations…

  15. Evaluation of Educational Administration: A Decade Review of Research (2001-2010)

    Science.gov (United States)

    Parylo, Oksana

    2012-01-01

    This sequential mixed methods study analyzed how program evaluation was used to assess educational administration and examined thematic trends in educational evaluation published over 10 years (2001-2010). First, qualitative content analysis examined the articles in eight peer-reviewed evaluation journals. This analysis revealed that numerous…

  16. 78 FR 20664 - Society of Clinical Research Associates-Food and Drug Administration: Food and Drug...

    Science.gov (United States)

    2013-04-05

    ... Clinical Practice AGENCY: Food and Drug Administration, HHS. ACTION: Notice of conference. SUMMARY: The... 8 a.m. to 5 p.m. Location: The conference will be held at the Renaissance Seattle Hotel, 515 Madison... community a high priority to help ensure the quality of FDA-regulated drugs and devices. The workshop helps...

  17. Evaluation of Educational Administration: A Decade Review of Research (2001-2010)

    Science.gov (United States)

    Parylo, Oksana

    2012-01-01

    This sequential mixed methods study analyzed how program evaluation was used to assess educational administration and examined thematic trends in educational evaluation published over 10 years (2001-2010). First, qualitative content analysis examined the articles in eight peer-reviewed evaluation journals. This analysis revealed that numerous…

  18. Parkinson's disease dementia: a diminished role for the Lewy body.

    Science.gov (United States)

    Libow, Leslie S; Frisina, Pasquale G; Haroutunian, Vahram; Perl, Daniel P; Purohit, Dushyant P

    2009-09-01

    The literature currently views Lewy bodies as central in the pathogenesis of Parkinson's disease dementia (PDD) when Alzheimer's disease (AD) or vascular pathology is not present. Because the neuropathology of PDD is not well understood, the pathological features of PDD were characterized in eighteen PD brain specimens using published criteria for AD, Diffuse Lewy Body Disease (DLBD), and Vascular Disease as a framework. Among the PD dementia (n=16) subjects, 3 (19%) did not have LBs outside of the brain stem, nor AD or vascular pathology. In two additional cases, one did have rare LBs in the neocortex and cingulate gyrus. However, these two cases did not meet the diagnostic criteria for DLBD. Beyond these 5 cases, the remaining PD dementia subjects fitted a classical pathological profile consistent with AD (38%), vascular disease (12.5%), DLBD (6%), or a combination of these pathologies (12.5%). The findings from this study do not support the hypothesis that LBs are the main substrate for dementia in PD. More research with a larger sample size is needed to determine whether the LB may be a secondary phenomenon and/or an "innocent-bystander". The entire role of the LB in PD dementia is again brought into question.

  19. National Aeronautics and Space Administration Biological and Physical Research Enterprise Strategy

    Science.gov (United States)

    2003-01-01

    As the 21st century begins, NASA's new Vision and Mission focuses the Agency's Enterprises toward exploration and discovery.The Biological and Physical Research Enterprise has a unique and enabling role in support of the Agency's Vision and Mission. Our strategic research seeks innovations and solutions to enable the extension of life into deep space safely and productively. Our fundamental research, as well as our research partnerships with industry and other agencies, allow new knowledge and tech- nologies to bring improvements to life on Earth. Our interdisciplinary research in the unique laboratory of microgravity addresses opportunities and challenges on our home planet as well as in space environments. The Enterprise maintains a key role in encouraging and engaging the next generation of explorers from primary school through the grad- uate level via our direct student participation in space research.The Biological and Physical Research Enterprise encompasses three themes. The biological sciences research theme investigates ways to support a safe human presence in space. This theme addresses the definition and control of physiological and psychological risks from the space environment, including radiation,reduced gravity, and isolation. The biological sciences research theme is also responsible for the develop- ment of human support systems technology as well as fundamental biological research spanning topics from genomics to ecologies. The physical sciences research theme supports research that takes advantage of the space environment to expand our understanding of the fundamental laws of nature. This theme also supports applied physical sciences research to improve safety and performance of humans in space. The research partnerships and flight support theme establishes policies and allocates space resources to encourage and develop entrepreneurial partners access to space research.Working together across research disciplines, the Biological and Physical

  20. Final report for the Department of Energy funded cooperative agreement ''Electronic Research Demonstration Project'' [University electronic research administration demonstration project

    Energy Technology Data Exchange (ETDEWEB)

    Rodman, John

    1998-07-31

    This is the final report for the Department of Energy (DOE) funded cooperative agreement ''Electronic Research Demonstration Project (DE-FC02-92ER35180)'' for the period August 1994-July 1998. The goal of the project, referred to as NewERA, was to demonstrate the use of open standards for electronic commerce to support research administration, otherwise referred to as Electronic Research Administration (ERA). The NewERA demonstration project provided a means to test interagency standards developed within the Federal Grant Electronic Commerce Committee, a group comprised of federal granting agencies. The NewERA program was initiated by DOE. NewERA was comprised of three separate, but related, ERA activities in preaward administration, postaward administration, and secure Internet commerce. The goal of New ERA was to demonstrate an open standard implementation of ERA using electronic data interchange, e-mail and Internet transaction security between grant applicants and DOE, along with t h e other participating agencies.

  1. Contrasting Frustrated Lewis Pair Reactivity with Selenium- and Boron-Based Lewis Acids.

    Science.gov (United States)

    Wilkins, Lewis C; Günther, Benjamin A R; Walther, Melanie; Lawson, James R; Wirth, Thomas; Melen, Rebecca L

    2016-09-05

    The activation of π-bonds in diynyl esters has been investigated by using soft and hard Lewis acids. In the case of the soft selenium Lewis acid PhSeCl, sequential activation of the alkyne bonds leads initially to an isocoumarin (1 equiv PhSeCl) and then to a tetracyclic conjugated structure with the isocoumarin subunit fused to a benzoselenopyran (3 equiv PhSeCl). Conversely, the reaction with the hard Lewis acidic borane B(C6 F5 )3 initiates a cascade reaction to yield a complex π-conjugated system containing phthalide and indene subunits. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. NASA RECON: Course development, administration, and evaluation. A research and development proposal

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Roquemore, Leroy

    1984-01-01

    This proposal addresses the development, administration, and evaluation of a set of transportable, college-level courses to educate science and engineering students in the effective use of automated scientific and technical information storage and retrieval systems, and, in particular, in the use of the NASA RECON system. Chapter 1 presents a brief introduction. Chapter 2 identifies general and specific objectives, i.e., needs analysis, course development, course administration, and course evaluation. Chapter 3 proposes the methodology to be used in successfully accomplishing these objectives. Chapter 4 highlights expected results and product deliverables, and Chapter 5 presents the project evaluation plan to be followed. Chapter 6 is a brief overview of the institutional resources available at the proposing institutions, i.e., at the University of Southwestern Louisiana and at Southern University to support the project. Chapter 7 proposes a budget, time schedule, and management plan. Chapter 8 is a summary of the foregoing.

  3. 76 FR 77008 - Notice of Administrative Boundary Change for Bureau of Land Management Offices in Montana To...

    Science.gov (United States)

    2011-12-09

    ... Bureau of Land Management Notice of Administrative Boundary Change for Bureau of Land Management Offices in Montana To Eliminate the County Split of Lewis and Clark County AGENCY: Bureau of Land Management... changed. The administrative boundary change will realign Lewis and Clark County, currently a split...

  4. Phosphorus Lewis acids: emerging reactivity and applications in catalysis.

    Science.gov (United States)

    Bayne, J M; Stephan, D W

    2016-02-21

    Part of the renaissance in main group chemistry has been a result of the focus on reactivity. This has led to the development of applications in stoichiometric reactivity and catalysis. In this tutorial review, we focus attention on the role of phosphorus-based Lewis acids in such advances. While early literature recognizes the role of P(iii) and P(v) electrophiles in coordination chemistry, it has generally been more recent studies that have focused on applications of this Lewis acidity. Applications of these novel P-based Lewis acids in stoichiometric reactivity, Lewis acid catalysis and frustrated Lewis pair (FLP) reactivity are reviewed. These advances demonstrate that P-based Lewis acids are a powerful tool for further developments in metal-free catalysis.

  5. Visual signs and symptoms of dementia with Lewy bodies

    OpenAIRE

    Armstrong, Richard A.

    2012-01-01

    Dementia with Lewy bodies ('Lewy body dementia' or 'diffuse Lewy body disease') (DLB) is the second most common form of dementia to affect elderly people, after Alzheimer's disease. A combination of the clinical symptoms of Alzheimer's disease and Parkinson's disease is present in DLB and the disorder is classified as a 'parkinsonian syndrome', a group of diseases which also includes Parkinson's disease, progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy. Ch...

  6. Exploring the Relationship between Special Education Teachers and Professional Learning Communities: Implications of Research for Administrators

    Science.gov (United States)

    Blanton, Linda P.; Perez, Yvette

    2011-01-01

    School accountability reports reveal that wide achievement gaps exist among different subgroups of students in PK-12 schools. Research findings reveal that general and special education teachers improve their classroom practices when working in professional learning communities (PLCs). In addition, research shows that special education teachers…

  7. Postdoctoral and Senior Postdoctoral Resident Research Associateship Program and Research Management Associateship Program for the National Aeronautics and Space Administration

    Science.gov (United States)

    1986-01-01

    Information on the status of all Resident Research Associated and Research Management Associates is provided. All Associated whose tenure continued as of June 1, 1985 are listed alphabetically by laboratory. Also included are their countries of citizenship and dates of tenure. The status of reporting obligations are summarized. A list of progress reports received during this reporting period is also provided. All Associates who terminated during the reporting period are listed.

  8. 78 FR 55728 - Society of Clinical Research Associates-Food and Drug Administration: Food and Drug...

    Science.gov (United States)

    2013-09-11

    ... interaction with FDA representatives. The program will focus on the relationships among FDA and clinical trial... Expects in a Pharmaceutical Clinical Trial; (4) Medical Device Aspects of Clinical Research; (5)...

  9. Tobacco regulatory science: research to inform regulatory action at the Food and Drug Administration's Center for Tobacco Products.

    Science.gov (United States)

    Ashley, David L; Backinger, Cathy L; van Bemmel, Dana M; Neveleff, Deborah J

    2014-08-01

    The U.S. Food and Drug Administration (FDA) promotes the development of regulatory science to ensure that a strong evidence base informs all of its regulatory activities related to the manufacture, marketing, and distribution of tobacco products as well as public education about tobacco product constituents and effects. Toward that end, the FDA's Center for Tobacco Products (CTP) provides funding for research studies with scientific aims that fall within its defined regulatory authority. However, given their traditional biomedical focus on basic and applied research, some researchers may not understand the principles of regulatory science or the types of studies CTP funds. The purpose of this paper is (1) to clarify the definition of regulatory science as a distinct scientific discipline, (2) to explore the role of tobacco regulatory science in order to help researchers understand the parameters and types of research that can be funded by CTP, and (3) to describe the types of research efforts that will inform the FDA's public health framework for tobacco product regulation. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

  10. A Correlation Analysis of the Relationship between Research Administrators at Predominately Undergraduate Institutions and Faculty Funding for Undergraduate Research

    Science.gov (United States)

    Waite, Joann

    2012-01-01

    The National Science Foundation data provided the necessary information for the investigation into the top 45 funded predominately undergraduate institutions. These funded institutions sponsored research office staff members were sent surveys regarding the servant leadership characteristics of their managers. The Results showed two areas of the…

  11. Synergy, compatibility, and innovation: merging Lewis acids with stereoselective enamine catalysis.

    Science.gov (United States)

    Gualandi, Andrea; Mengozzi, Luca; Wilson, Claire M; Cozzi, Pier Giorgio

    2014-04-01

    In recent years there has been an accelerated rate of development in the field of organocatalysis, with asymmetric organocatalysis now reaching full maturity. The invention of new organocatalytic reactions and the exploration of new concepts now appear in tandem with the application of organocatalytic techniques in the synthesis of natural products and active pharmaceutical ingredients (APIs). After a "golden rush" in organocatalysis, researchers are now starting to combine different methods, thereby taking advantage of the significant benefits of synergy. Metals are used in combination with organocatalytic processes, thus reaching complexity that is found in nature, where enzymes take advantage of the presence of certain metals to increase the arsenal of organic transformations available. In this Focus review, we illustrate the possibility of a "happy marriage" between Lewis acids and organocatalytic stereoselective processes. Questions have been raised about the combination of Lewis acids and organocatalysis owing to the presence of water and/or strong bases in these processes. Some Lewis acids have been shown to be compatible with organocatalysis and concepts relating to their use will be illustrated herein. To summarize the fruitful use of Lewis acids in stereoselective organocatalytic processes, we will draw attention to the advantages and selectivity achieved using this method.

  12. Publicly administrated nuclear waste management research programme 1994-1996. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Vuori, S. [ed.] [VTT Energy, Espoo (Finland)

    1997-09-01

    The main objective of the JYT-programme has been to provide the authorities with independent information and research results relevant for the safety of nuclear waste management. The main emphasis in this research programme has been devoted to the final disposal of spent fuel. The whole area of the research programme has been subdivided into following main topic areas: (1) bedrock structure and stability, rock investigation methods and characteristics and flow of ground water, (2) release of radionuclides from a repository and subsequent transport in the bedrock, (3) performance and safety assessment of repositories and other phases of nuclear waste management, (4) natural analogue studies, (5) waste management technology and costs and (6) socio political and other societal issues and environmental impact assessment.

  13. Carnap and Lewis on the External World

    Directory of Open Access Journals (Sweden)

    Ivan Ferreira da Cunha

    2014-08-01

    Full Text Available This paper compares the claims about our knowledge of the external world presented by Rudolf Carnap, in the book known as the Aufbau, to those of Clarence Irving Lewis, in Mind and the World-Order. This comparison is made in terms of the opposition to Kantian epistemology that both books establish; the Aufbau is regarded as the peak of the logicist tradition and Mind and the World-Order is taken in continuity with pragmatism. It is found that both books present knowledge of the external world as a consequence of a structural organization of human experience. However, there is an important point of divergence: the concept of verification each author adopts is different, such a concept was even a matter of discussion between Lewis and the Vienna Circle. This paper shows this disagreement but also shows how Carnap changed his point of view in the decade after the Aufbau was published, towards a standpoint which is much closer to Lewis’s ideas. In that process, nevertheless, Carnap changed his focus and did not deal with the problem of the external world anymore. This paper also seeks to draw attention to some features of the relation between Carnap and the pragmatist tradition which have only recently started to attract interest.

  14. Exercise for Individuals with Lewy Body Dementia: A Systematic Review.

    Directory of Open Access Journals (Sweden)

    Michael Inskip

    Full Text Available Individuals with Lewy body Dementia (LBD, which encompasses both Parkinson disease dementia (PDD and Dementia with Lewy Bodies (DLB experience functional decline through Parkinsonism and sedentariness exacerbated by motor, psychiatric and cognitive symptoms. Exercise may improve functional outcomes in Parkinson's disease (PD, and Alzheimer's disease (AD. However, the multi-domain nature of the LBD cluster of symptoms (physical, cognitive, psychiatric, autonomic results in vulnerable individuals often being excluded from exercise studies evaluating physical function in PD or cognitive function in dementia to avoid confounding results. This review evaluated existing literature reporting the effects of exercise interventions or physical activity (PA exposure on cluster symptoms in LBD.A high-sensitivity search was executed across 19 databases. Full-length articles of any language and quality, published or unpublished, that analysed effects of isolated exercise/physical activity on indicative Dementia with Lewy Bodies or PD-dementia cohorts were evaluated for outcomes inclusive of physical, cognitive, psychiatric, physiological and quality of life measures. The protocol for this review (Reg. #: CRD42015019002 is accessible at http://www.crd.york.ac.uk/PROSPERO/.111,485 articles were initially retrieved; 288 full articles were reviewed and 89.6% subsequently deemed ineligible due to exclusion of participants with co-existence of dementia and Parkinsonism. Five studies (1 uncontrolled trial, 1 randomized controlled trial and 3 case reports evaluating 16 participants were included. Interventions were diverse and outcome homogeneity was low. Habitual gait speed outcomes were measured in 13 participants and increased (0.18m/s, 95% CI -0.02, 0.38m/s, exceeding moderate important change (0.14m/s for PD cohorts. Other outcomes appeared to improve modestly in most participants.Scarce research investigating exercise in LBD exists. This review confirms

  15. 78 FR 52080 - Potato Research and Promotion Plan; Amend the Administrative Committee Structure and Delete the...

    Science.gov (United States)

    2013-08-22

    .... Interested persons wanting to contact the Board can reach them through their Web site, Facebook, or... amendments to the regulations. The Board can easily be contacted by using their Web site, Facebook or... proposed rule. List of Subjects in 7 CFR Part 1207 Advertising, Agricultural research, Imports,...

  16. It Takes an Eco-System: A Review of the Research Administration Technology Landscape

    Science.gov (United States)

    Saas, Tyler; Kemp, James

    2017-01-01

    Deloitte Consulting LLP conducted a review of publicly available data sources with the goal of identifying the pre- and post-award systems used in higher education. The number and type of pre- and post-award systems identified not only show that higher education institutions (HEIs) use a variety of methods to facilitate research activities, but…

  17. Energy Research and Development Administration Ad Hoc Computer Networking Group: experimental program

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, I.

    1975-03-19

    The Ad Hoc Computer Networking Group was established to investigate the potential advantages and costs of newer forms of remote resource sharing and computer networking. The areas of research and investigation that are within the scope of the ERDA CNG are described. (GHT)

  18. Internet Administration of Paper-and-Pencil Questionnaires Used in Couple Research: Assessing Psychometric Equivalence

    Science.gov (United States)

    Brock, Rebecca L.; Barry, Robin A.; Lawrence, Erika; Dey, Jodi; Rolffs, Jaci

    2012-01-01

    This study examined the psychometric equivalence of paper-and-pencil and Internet formats of key questionnaires used in couple research. Self-report questionnaires assessing interpersonal constructs (relationship satisfaction, communication/conflict management, partner support, emotional intimacy) and intrapersonal constructs (individual traits,…

  19. Graduate programs in health administration: faculty academic reputation and faculty research reputation by program location and program reputation.

    Science.gov (United States)

    Nowicki, M

    1995-01-01

    This study used program location and program reputation to describe two important faculty characteristics: academic reputation and research reputation. The study involved 44 graduate programs in health administration representing four program locations: schools of public health, business, medicine/allied health, and graduate/independent. Fourteen programs were identified as ranked programs and the remaining 30 programs were identified as unranked programs. While the study identifies many differences, few are significant, thus adding credence to the argument for diversity in program location and diminishing credence in the argument for program reputation.

  20. Interview with Smithsonian NASM Spacesuit Curator Dr. Cathleen Lewis

    Science.gov (United States)

    Lewis, Cathleen; Wright, Rebecca

    2012-01-01

    Dr. Cathleen Lewis was interviewed by Rebecca Wright during the presentation of an "Interview with Smithsonian NASM Spacesuit Curator Dr. Cathleen Lewis" on May 14, 2012. Topics included the care, size, and history of the spacesuit collection at the Smithsonian and the recent move to the state-of-the-art permanent storage facility at the Udvar-Hazy facility in Virginia.

  1. Impairments of Speech Fluency in Lewy Body Spectrum Disorder

    Science.gov (United States)

    Ash, Sharon; McMillan, Corey; Gross, Rachel G.; Cook, Philip; Gunawardena, Delani; Morgan, Brianna; Boller, Ashley; Siderowf, Andrew; Grossman, Murray

    2012-01-01

    Few studies have examined connected speech in demented and non-demented patients with Parkinson's disease (PD). We assessed the speech production of 35 patients with Lewy body spectrum disorder (LBSD), including non-demented PD patients, patients with PD dementia (PDD), and patients with dementia with Lewy bodies (DLB), in a semi-structured…

  2. Dalgarno-Lewis perturbation theory for scattering states

    Energy Technology Data Exchange (ETDEWEB)

    Amore, Paolo [Facultad de Ciencias, Universidad de Colima, Bernal Diaz del Castillo 340, Colima, Colima Mexico (Mexico)]. E-mail: paolo@ucol.mx; Fernandez, Francisco M. [INIFTA (Conicet, UNLP), Division Quimica Teorica, Diag. 113 y 64 S/N, Sucursal 4, Casilla de Correo 16, 1900 La Plata (Argentina)]. E-mail: fernande@quimica.unlp.edu.ar

    2007-07-23

    We apply the method of Dalgarno and Lewis to scattering states and discuss the choice of the unperturbed model in order to have a convergent perturbation series for the phase shift. We show that a recently proposed approach is a particular case of the method of Dalgarno and Lewis.

  3. A RESEARCH FOR THE USAGE LEVEL OF MANAGEMENT INFORMATION SYSTEMS BY SCHOOL ADMINISTRATORS

    Directory of Open Access Journals (Sweden)

    Said Kingir‎

    2013-06-01

    Full Text Available Denominated as the information age of today provided a better understanding of the value of the information day by day. The use of information technology in the globalization of the economy offers a serious competitive advantage to businesses. Even though it is foreseen to provide an economic superiority in the first place, the management information systems affect the structure and functioning of many different organizations in a positive aspect. In this context, the educational institutions that we may discuss can not be excluded. The sole aim of which is to train students in educational institutions in accordance with the objectives of the education system, the efficient use of management information systems certainly have a positive effect on this process. Decision-making processes of managers on management information systems and knowledge management provides great support to the school administrators. Management information systems in order to improve the quality of education and training in educational institutions are actively used captured that success can be said to constitute one of the pillars in the success of our young people who will shape our future. The universe of the study consists of the schools in the city centre of Diyarbakir. As the means of collecting data, questionnaire was used in the study. The data were obtained from the survey evaluated in the 18th version of Statistical Packages for the Social Sciences. Prepared for this purpose with this study of school administrators’, working in educational institutions, utilization levels and the scope of the management information systems in their institutions are discussed.

  4. LEWIS BINFORD AND HIS MORAL MAJORITY (Lewis Binford y su mayoría moral

    Directory of Open Access Journals (Sweden)

    Alice Beck Kehoe

    2011-06-01

    Full Text Available This essay looks at the late Lewis Binford’s career from the standpoint of sociology of science. His thinking and manner reflect his socialization in Virginia Baptist subculture. As convinced of his authority on science as Jerry Falwell was of his authority on Biblical morality, Lewis Binford and his third wife Sally Rosen Binford excited a group of 1960s students to follow Lewis in an outmoded version of science (hypothetico-deductive and in trusting statistics. The “frames of reference” he laboriously constructed are naïve on environmental interpretation and, because he expressed contempt for “political” aspects of archaeology, fail to take into account effects of colonialism. His work is often scientistic, in the “modern” mode that historian Dorothy Ross describes as characteristic of twentieth-century American social sciences. ESPAÑOL: En este ensayo se analiza la etapa final de la carrera de Lewis Binford desde el punto de vista de la sociología de la ciencia. Su pensamiento refleja su socialización en el seno de la subcultura de la Virginia baptista. Tan convencido de su autoridad en la ciencia como Jerry Falwell lo fuera sobre la moralidad bíblica, Lewis Binford y su tercera esposa Sally Rosen Binford animaron a un grupo estudiantes de los sesenta a seguir a Lewis a través de una versión anticuada de la ciencia (hipotético-deductiva y a confiar en la estadística. Los “marcos de referencia” que laboriosamente construyó son ingenuos en la interpretación del medio ambiente y, como expresó el desprecio por los aspectos “políticos” de la arqueología, no tienen en cuenta los efectos del colonialismo. Su trabajo es a menudo cientificista, en el sentido “moderno” que la historiadora Dorothy Ross describe como una característica de las ciencias sociales norteamericanas del siglo XX.

  5. Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies.

    Science.gov (United States)

    Sarro, Lidia; Senjem, Matthew L; Lundt, Emily S; Przybelski, Scott A; Lesnick, Timothy G; Graff-Radford, Jonathan; Boeve, Bradley F; Lowe, Val J; Ferman, Tanis J; Knopman, David S; Comi, Giancarlo; Filippi, Massimo; Petersen, Ronald C; Jack, Clifford R; Kantarci, Kejal

    2016-10-01

    Alzheimer's disease pathology frequently coexists with Lewy body disease at autopsy in patients with probable dementia with Lewy bodies. More than half of patients with probable dementia with Lewy bodies have high amyloid-β deposition as measured with (11)C-Pittsburgh compound B binding on positron emission tomography. Biomarkers of amyloid-β deposition precede neurodegeneration on magnetic resonance imaging during the progression of Alzheimer's disease, but little is known about how amyloid-β deposition relates to longitudinal progression of atrophy in patients with probable dementia with Lewy bodies. We investigated the associations between baseline (11)C-Pittsburgh compound B binding on positron emission tomography and the longitudinal rates of grey matter atrophy in a cohort of clinically diagnosed patients with dementia with Lewy bodies (n = 20), who were consecutively recruited to the Mayo Clinic Alzheimer's Disease Research Centre. All patients underwent (11)C-Pittsburgh compound B positron emission tomography and magnetic resonance imaging examinations at baseline. Follow-up magnetic resonance imaging was performed after a mean (standard deviation) interval of 2.5 (1.1) years. Regional grey matter loss was determined on three-dimensional T1-weighted magnetic resonance imaging with the tensor-based morphometry-symmetric normalization technique. Linear regression was performed between baseline (11)C-Pittsburgh compound B standard unit value ratio and longitudinal change in regional grey matter volumes from an in-house modified atlas. We identified significant associations between greater baseline (11)C-Pittsburgh compound B standard unit value ratio and greater grey matter loss over time in the posterior cingulate gyrus, lateral and medial temporal lobe, and occipital lobe as well as caudate and putamen nuclei, after adjusting for age (P < 0.05). Greater baseline (11)C-Pittsburgh compound B standard unit value ratio was also associated with greater

  6. Space Research Data Management in the National Aeronautics and Space Administration

    Science.gov (United States)

    Ludwig, G. H.

    1986-01-01

    Space related scientific research has passed through a natural evolutionary process. The task of extracting the meaningful information from the raw data is highly involved and will require data processing capabilities that do not exist today. The results are presented of a three year examination of this subject, using an earlier report as a starting point. The general conclusion is that there are areas in which NASA's data management practices can be improved and recommends specific actions. These actions will enhance NASA's ability to extract more of the potential data and to capitalize on future opportunities.

  7. National Aeronautics and Space Administration fundamental research program. Information utilization and evaluation, appendices

    Science.gov (United States)

    Estes, J. E.; Eisgruber, L.

    1981-01-01

    Important points presented and recommendations made at an information and decision processes workshop held in Asilomar, California; at a data and information performance workshop held in Houston, Texas; and at a data base use and management workshop held near San Jose, California are summarized. Issues raised at a special session of the Soil Conservation Society of America's remote sensing for resource management conference in Kansas City, Missouri are also highlighted. The goals, status and activities of the NASA program definition study of basic research requirements, the necessity of making the computer science community aware of user needs with respect to information related to renewable resources, performance parameters and criteria for judging federal information systems, and the requirements and characteristics of scientific data bases are among the topics reported.

  8. Dementia with Lewy bodies: current concepts.

    Science.gov (United States)

    Buracchio, Teresa; Arvanitakis, Zoe; Gorbien, Martin

    2005-01-01

    As life expectancy continues to increase over time, dementia is becoming an increasingly more common problem and a major cause of disability in older persons. It is now more important than ever to identify and manage common causes of dementia given variations in disease course, treatments and the possibility for modification of risk factors. Dementia with Lewy bodies (DLB) is a dementia syndrome characterized by progressive cognitive decline, with fluctuating cognition, recurrent detailed and well-formed hallucinations, and parkinsonism. This article aims to provide an overview of current concepts of DLB, including a description of the key clinical features and neuropathology, neurochemistry, and genetics of DLB, then a discussion of the relationship of DLB with Alzheimer's disease and Parkinson's disease, and, finally, a summary of current management strategies available for this disorder.

  9. Aluminium Diphosphamethanides: Hidden Frustrated Lewis Pairs.

    Science.gov (United States)

    Styra, Steffen; Radius, Michael; Moos, Eric; Bihlmeier, Angela; Breher, Frank

    2016-07-04

    The synthesis and characterisation of two aluminium diphosphamethanide complexes, [Al(tBu)2 {κ(2) P,P'-Mes*PCHPMes*}] (3) and [Al(C6 F5 )2 {κ(2) P,P'-Mes*PCHPMes*}] (4), and the silylated analogue, Mes*PCHP(SiMe3 )Mes* (5), are reported. The aluminium complexes feature four-membered PCPAl core structures consisting of diphosphaallyl ligands. The silylated phosphine 5 was found to be a valuable precursor for the synthesis of 4 as it cleanly reacts with the diaryl aluminium chloride [(C6 F5 )2 AlCl]2 . The aluminium complex 3 reacts with molecular dihydrogen at room temperature under formation of the acyclic σ(2) λ(3) ,σ(3) λ(3) -diphosphine Mes*PCHP(H)Mes* and the corresponding dialkyl aluminium hydride [tBu2 AlH]3 . Thus, 3 belongs to the family of so-called hidden frustrated Lewis pairs.

  10. The Uses of Research Sponsored by the Administration on Aging (AoA). Case Study No. 1. Transportation Services for the Elderly. Executive Summary.

    Science.gov (United States)

    Yin, Robert K.; Heinsohn, Ingrid

    This case study, one in a series of research efforts designed to examine the utilization of the Administration on Aging's research, describes the different types of uses of materials produced by a research project on improvement of transportation services for the elderly. (The materials are a state-of-the-art report, planning handbook, and…

  11. The Uses of Research Sponsored by the Administration on Aging (AoA). Case Study No. 2. Older Americans Resources and Services (OARS). Executive Summary.

    Science.gov (United States)

    Yin, Robert K.; Heinsohn, Ingrid

    This case study, one in a series of research efforts designed to examine the utilization of the Administration on Aging's research, discusses reasons for the wide utilization of the Older Americans Resources and Services (OARS) research. (The OARS methodology assesses the levels of functioning of individual elderly persons. The resulting…

  12. Administrative and curricular reform for improved environmental education and research at the university

    Energy Technology Data Exchange (ETDEWEB)

    Cobb, T.B. [Bowling Green State Univ., OH (United States). Dept. of Physics and Astronomy

    1996-12-31

    Institutes of higher education have a clear responsibility for research and education regarding the environment. Indeed, higher education is uniquely entrusted by the general public to provide unbiased and factual information about environmental issues for use in decisions regarding choices of appropriate technologies, personal lifestyles, social values, economics, law, public policy, and in many other areas. This situation places a great responsibility on the faculty members of these institutions. Not only must they be experts in their own discipline, but they also must be able to interpret social issues and translate complex and often poorly-understood theories and data to the public in a manner which is, on the one hand unbiased and representative of the known science, but on the other substantive, concise, and pertinent for the question at hand. Global warming provides a perfect example of this dilemma. Science principles from several disciplines must be integrated and translated into rational public policy in an environment of confusing and uncertain effects of specific actions. As a consequence, the public often is left confused and the esteem of the university and the associated faculty is thereby reduced.

  13. Evaluation of School Administrators. NAESP School Leadership Digest Series, Number Five. ERIC/CEM Research Analysis Series, Number Seven.

    Science.gov (United States)

    Barraclough, Terry

    Administrators have always been evaluated in one way or another. Decisions on hiring, training, promotion, and firing of administrators have always been necessary; such decisions are based on some sort of evaluation, whether formal or informal, of administrative performance. The concept of accountability has also affected administrator evaluation.…

  14. 行政组织法基本范畴与新课题%Basis Categories and New Research on the Administrative Organization Law

    Institute of Scientific and Technical Information of China (English)

    任进

    2012-01-01

    The administrative organization law is an essential part of Constitutional and administrative laws. It is generally thought that modem administrative organizations refer to administrative organs exercising national administrative powers and administering public affairs and other organizations exercising administrative powers. The connotation of administrative organizations differs from administrative organs, administrative institutions and administrative subjects. Besides, other categories should be analyzed such as differences between administrative organizations authorized by administrative organs and by laws and regulations, differences between administrative subjects and enforcement subjects of administrative laws. Since the functions of the administrative organization law has been increasingly recognized, such as allocating power limit, regulating formation of organizations and personnel, and safeguarding citizens' legitimate rights and interest according to law, research on the administrative organization law shall be paid more attention. As the administrative reform deepens, more topics require research by academia with the development of the administrative organization law.%行政组织法是宪法和行政法的重要内容之一。一般认为,现代意义的行政组织,是指行使国家行政职权、管理公共事务的行政机关以及其他行使行政职权的组织的总体。行政组织与行政机关、行政机构、行政主体含义不同,行政组织授权与法律法规授权,行政主体与行政执法主体等基本范畴也需要梳理和辨析。行政组织法对于配置职能权限、规范机构设置和编制、依法保障公民合法权益所起的重要作用已日益为人们所认识,对行政组织法的研究,也应引起重视。

  15. Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats.

    Directory of Open Access Journals (Sweden)

    Cheng-bo Fang

    Full Text Available PURPOSE: To investigate the efficacy of leflunomide in experimental autoimmune uveitis (EAU in rats. METHODS: Lewis rats were immunized with interphotoreceptor retinoid-binding peptide (IRBP in order to generate EAU. Rats received three dose of leflunomide through intragastric administration (prevention or treatment protocols after immunization at three separate doses (3 mg/kg/d; 6 mg/kg/d; 12 mg/kg/d. Cyclosporin A was administered as a positive control. Rats were euthanized during peak disease activity (day 14 or 15. Treatment effectiveness was evaluated in vivo using clinical EAU scoring (d14 and histopathological evaluation of enucleated eyes after experimental termination. The expression levels of inflammatory cytokines in the serum were quantified by ELISA. Eyeball of rats were harvested and mRNA expression of interleukin 17 (IL17 and IFN-γ were quantified through RT-PCR. Intracellular expression of interleukin (IL-17 in the activated CD4(+ T cells was assessed by flow cytometry. The effects of leflunomide inhibition on immune responses in rats were investigated in isolated lymphocytes. RESULTS: Histopathological and clinical data revealed severe intraocular inflammation in the immunized rat. Inflammation reached its peak on day 14 in this EAU model. Treatment with leflunomide significantly prevented and treated EAU-induced ocular inflammation and decreased clinical and pathological scores compared to vehicle-treated eyes. Gene expression of IL17 and IFN-γ was markedly reduced in leflunomide-treated eyes. Leflunomide significantly decreased the serum levels of IL17 and IFN-γ. The study of IL17+ T cells in peripheral blood and spleen by flow cytometry showed a decreased number of Th17 cell in rats of leflunomide prevented group. Lymphocytes from animals treated with leflunomide had decreased antigen-specific proliferation in vitro compared with lymphocytes from untreated animals. CONCLUSIONS: Oral administration of leflunomide

  16. Integration of structural health monitoring solutions onto commercial aircraft via the Federal Aviation Administration structural health monitoring research program

    Science.gov (United States)

    Swindell, Paul; Doyle, Jon; Roach, Dennis

    2017-02-01

    The Federal Aviation Administration (FAA) started a research program in structural health monitoring (SHM) in 2011. The program's goal was to understand the technical gaps of implementing SHM on commercial aircraft and the potential effects on FAA regulations and guidance. The program evolved into a demonstration program consisting of a team from Sandia National Labs Airworthiness Assurance NDI Center (AANC), the Boeing Corporation, Delta Air Lines, Structural Monitoring Systems (SMS), Anodyne Electronics Manufacturing Corp (AEM) and the FAA. This paper will discuss the program from the selection of the inspection problem, the SHM system (Comparative Vacuum Monitoring-CVM) that was selected as the inspection solution and the testing completed to provide sufficient data to gain the first approved use of an SHM system for routine maintenance on commercial US aircraft.

  17. Energy efficiency campaign for residential housing at the Fort Lewis army installation

    Energy Technology Data Exchange (ETDEWEB)

    AH McMakin; RE Lundgren; EL Malone

    2000-02-23

    In FY1999, Pacific Northwest National Laboratory conducted an energy efficiency campaign for residential housing at the Fort Lewis Army Installation near Tacoma, Washington. Preliminary weather-corrected calculations show energy savings of 10{percent} from FY98 for energy use in family housing. This exceeded the project's goal of 3{percent}. The work was funded by the U.S. DOEs Federal Energy Management Program (FEMP), Office of Energy Efficiency and Renewable Energy. The project adapted FEMP's national ``You Have the Power Campaign'' at the local level, tailoring it to the military culture. The applied research project was designed to demonstrate the feasibility of tailored, research-based strategies to promote energy conservation in military family housing. In contrast to many energy efficiency efforts, the campaign focused entirely on actions residents could take in their own homes, as opposed to technology or housing upgrades. Behavioral change was targeted because residents do not pay their own utility bills; thus other motivations must drive personal energy conservation. This campaign augments ongoing energy savings from housing upgrades carried out by Fort Lewis. The campaign ran from September 1998 through August 1999. The campaign strategy was developed based on findings from previous research and on input from residents and officials at Fort Lewis. Energy use, corrected to account for weather differences, was compared with the previous year's use. Survey responses from 377 of Fort Lewis residents of occupied housing showed that the campaign was moderately effective in promoting behavior change. Of those who were aware of the campaign, almost all said they were now doing one or more energy-efficient things that they had not done before. Most people were motivated by the desire to do the right thing and to set a good example for their children. They were less motivated by other factors.

  18. Lewis Acid-Base, Molecular Modeling, and Isotopic Labeling in a Sophomore Inorganic Chemistry Laboratory

    Science.gov (United States)

    Nataro, Chip; Ferguson, Michelle A.; Bocage, Katherine M.; Hess, Brian J.; Ross, Vincent J.; Swarr, Daniel T.

    2004-01-01

    An experiment to prepare a deuterium labeled adduct of a Lewis acid and Lewis base, to use computational methods allowing students to visualize the LUMO of Lewis acids, the HOMO of Lewis bases and the molecular orbitals of the adduct that is formed is developed. This allows students to see the interplay between calculated and experimental results.

  19. [Origin of Lewis acidity in solid materials]. DOE Final Report for Grant DE-FG02-90ER14130

    Energy Technology Data Exchange (ETDEWEB)

    Fripiat, J. J.

    2001-04-11

    The aim of the research undertaken within the framework of this DOE grant was to further understanding of the origin of the Lewis acidity in solid materials. The study centered around aluminas and alumino-silicates. The main tools for investigation of this phenomenon were high-resolution solid state {sub 27}Al NMR, complemented by EPR and the chemical determination of catalytic activity.

  20. I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature Review

    Directory of Open Access Journals (Sweden)

    Eun Joo Chung

    2015-05-01

    Full Text Available Lewy body-related disorders are characterized by the presence of Lewy bodies and Lewy neurites, which have abnormal aggregations of α-synuclein in the nigral and extranigral areas, including in the heart. 123I-metaiodobenzylguanidine (MIBG scintigraphy is a well-known tool to evaluate cardiac sympathetic denervation in the Lewy body-related disorders. MIBG scintigraphy showed low uptake of MIBG in the Lewy body-related disorders, including Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure and rapid eye movement sleep behavior disorder. This review summarizes previous results on the diagnostic applications of MIBG scintigraphy in Lewy body-related disorders.

  1. Administrative Ethics Research Based on Government Microblog:Disciplines Perspective and Research Methodology%基于政务微博的行政伦理研究

    Institute of Scientific and Technical Information of China (English)

    王亚强; 张雅丽

    2013-01-01

    基于自媒体特征优势而凸显出其实用效能的政务微博已被纳入各国政府信息化建设的内容之中。由模式演进与中西方研究状况可知,行政伦理研究正趋于规范化,责任意识凸显,基于政务微博的行政伦理研究日渐重要。我国政务微博发展可划分为微博示政、微博问政、微博行政三个阶段,可通过案例分析、概念凝练、运行过程和规约方式研究来构建合乎理性的政务微博条件下的行政伦理规范体系。多学科交叉及其不确定性决定了基于政务微博的行政伦理研究必然要涉及社会学、管理学、政治学、电子网络技术等多学科领域。在具体实践中,可通过实证主义、系统整合、历史与逻辑统一的方法来进行研究,最终通过制度安排来实现伦理规约。%The government microblog with its “We the Media”advantages and practical performances has become an important part of the information technology construction of almost every government.It shows from the model evolution and the current research in China and in the West that administrative ethics research is be-coming more and more standardized and highlighting the sense of responsibility,and therefore administrative ethics research based on government microblogging is increasingly important.The development of China's gov-ernment microblog can be divided into three phrases:“Weibo Shizheng (government microblogging of incoming communications)”,“Weibo Wenzheng (government microblogging of public -involved Q&A)”and “Weibo Xingzheng (government microblogging of outbound communications)”.This thesis,through case studies,con-densed research concepts and researches on operational processes and stipulations,attempts to construct the ad-ministrative ethics system within the rational government microblogging conditions.Owing to the interdisciplinary and multidisciplinary uncertainty

  2. Hydrogen activation using a novel tribenzyltin Lewis acid.

    Science.gov (United States)

    Cooper, Robert T; Sapsford, Joshua S; Turnell-Ritson, Roland C; Hyon, Dong-Hun; White, Andrew J P; Ashley, Andrew E

    2017-08-28

    Over the last decade there has been an explosion in the reactivity and applications of frustrated Lewis pair (FLP) chemistry. Despite this, the Lewis acids (LAs) in these transformations are often boranes, with heavier p-block elements receiving surprisingly little attention. The novel LA Bn3SnOTf (1) has been synthesized from simple, inexpensive starting materials and has been spectroscopically and structurally characterized. Subtle modulation of the electronics at the tin centre has led to an increase in its Lewis acidity in comparison with previously reported R3SnOTf LAs, and has facilitated low temperature hydrogen activation and imine hydrogenation. Deactivation pathways of the R3Sn(+) LA core have also been investigated.This article is part of the themed issue 'Frustrated Lewis pair chemistry'. © 2017 The Authors.

  3. Is It Lewy Body Dementia or Something Else?

    Science.gov (United States)

    ... Options Join the fight against LBD! Donate Is It LBD or Something Else? Early and accurate diagnosis ... dementia with Lewy bodies’ (DLB). Symptoms that differentiate it from Alzheimer’s include unpredictable levels of cognitive ability, ...

  4. Impact of predatory threat on fear extinction in Lewis rats

    OpenAIRE

    Goswami, Sonal; Cascardi, Michele; Rodríguez-Sierra, Olga E.; Duvarci, Sevil; Paré, Denis

    2010-01-01

    Humans with post-traumatic stress disorder (PTSD) are deficient at extinguishing conditioned fear responses. A study of identical twins concluded that this extinction deficit does not predate trauma but develops as a result of trauma. The present study tested whether the Lewis rat model of PTSD reproduces these features of the human syndrome. Lewis rats were subjected to classical auditory fear conditioning before or after exposure to a predatory threat that mimics a type of traumatic stress ...

  5. Measuring Outcomes of Nursing Practice, Education, and Administration. Proceedings of the Annual SCCEN Research Conference (1st, Austin, Texas, December 4-5, 1981).

    Science.gov (United States)

    Field, William E., Jr., Ed.

    Thirty-five papers on the measurement of outcomes of nursing practice, education, and administration are presented from the 1981 research conference of the Southern Council on Collegiate Education for Nursing. Papers and authors include the following: "Why Nursing Research?" (Hildegard E. Peplau); "Job Satisfaction in Nurse Faculty: Test of a…

  6. A Content analysis of articles published in Journal of the School of Business Administration: Marketing and marketing research (1972-2007)

    OpenAIRE

    BOZBAY, Zehra

    2008-01-01

    The study examined the trends of marketing articles published in Journal of the School of Business Administration, Istanbul University using content analysis method. The main objective of the study was to identify marketing and marketing research articles published in Journal of the School of Business Administration between years 1972-2007 and to assess publications' contents in order to determine the marketing trends. The trends and development in marketing were documented by the help ...

  7. A Content analysis of articles published in Journal of the School of Business Administration: Marketing and marketing research (1972-2007)

    OpenAIRE

    BOZBAY, Zehra

    2012-01-01

    The study examined the trends of marketing articles published in Journal of the School of Business Administration, Istanbul University using content analysis method. The main objective of the study was to identify marketing and marketing research articles published in Journal of the School of Business Administration between years 1972-2007 and to assess publications' contents in order to determine the marketing trends. The trends and development in marketing were documented by the ...

  8. Lewis base activation of Lewis acids: catalytic, enantioselective vinylogous aldol addition reactions.

    Science.gov (United States)

    Denmark, Scott E; Heemstra, John R

    2007-07-20

    The generality of Lewis base catalyzed, Lewis acid mediated, enantioselective vinylogous aldol addition reactions has been investigated. The combination of silicon tetrachloride and chiral phosphoramides is a competent catalyst for highly selective additions of a variety of alpha,beta-unsaturated ketone-, 1,3-diketone-, and alpha,beta-unsaturated amide-derived dienolates to aldehydes. These reactions provided high levels of gamma-site selectivity for a variety of substitution patterns on the dienyl unit. Both ketone- and morpholine amide-derived dienol ethers afforded high enantio- and diastereoselectivity in the addition to conjugated aldehydes. Although alpha,beta-unsaturated ketone-derived dienolate did not react with aliphatic aldehydes, alpha,beta-unsaturated amide-derived dienolates underwent addition at reasonable rates affording high yields of vinylogous aldol product. The enantioselectivities achieved with the morpholine derived-dienolate in the addition to aliphatic aldehydes was the highest afforded to date with the silicon tetrachloride-chiral phosphoramide system. Furthermore, the ability to cleanly convert the morpholine amide to a methyl ketone was demonstrated.

  9. Biomarkers of Parkinson's disease and Dementia with Lewy bodies.

    Science.gov (United States)

    Henchcliffe, Claire; Dodel, Richard; Beal, M Flint

    2011-12-01

    Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) are progressive and disabling neurodegenerative disorders, in which signs and symptoms overlap with each other and with other neurodegenerative conditions. Currently, diagnosis, measurement of progression, and response to therapeutic intervention rely upon clinical observation. However, there remains a critical need for validated biomarkers in each of these areas. A definitive diagnostic test would improve clinical management and enrollment into clinical trials. An objective measure of progression is vitally important in identifying neuroprotective interventions. Biomarkers may also provide insight into pathogenesis, and might therefore suggest possible novel targets for therapeutic intervention. In addition, certain biomarkers might be of use in monitoring the biochemical and physiological effects of therapeutic interventions. Development of diagnostic biomarkers has focused until recently upon imaging techniques based upon measuring loss of dopamine neurons. Additionally, advances in understanding the genetic contribution to neurodegenerative disorders, in particular in PD, have identified multiple causative genes and risk factors that in some cases may help estimate PD risk. However, recent availability of increasingly sophisticated bioinformatics technology has rendered development of fluid biomarkers feasible, opening the possibility of generally accessible blood or cerebrospinal fluid (CSF) tests that could impact upon diagnosis, management, and research in PD, PDD, and DLB.

  10. Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease.

    Science.gov (United States)

    Frigerio, Roberta; Fujishiro, Hiroshige; Maraganore, Demetrius M; Klos, Kevin J; DelleDonne, Anthony; Heckman, Michael G; Crook, Julia E; Josephs, Keith A; Parisi, Joseph E; Boeve, Bradley F; Dickson, Dennis W; Ahlskog, J Eric

    2009-09-01

    To explore whether associations of potential risk factors for incidental Lewy body disease (iLBD) are similar to those for Parkinson disease (PD). Brain autopsy study (1988-2004) of subjects without evidence of neurodegenerative disease or tremor who were evaluated by at least 1 physician within 1 year of death. Researchers analyzed incidental Lewy pathology blinded to clinical abstraction. Olmsted County, Minnesota. Subjects Residents of Olmsted County and the immediate vicinity aged older than 60 years. Whether risk factors previously associated with PD in Olmsted County are also associated with iLBD. Of 235 subjects, 34 had iLBD (14.5%). The overall risk factor profiles for iLBD and PD were fairly similar between the 2 sets of odds ratio (OR) estimates, with 11 of 16 ORs in the same direction. Prior Olmsted County studies documented 7 risk factors with statistically significant associations with PD; for physician occupation and caffeine intake, the ORs for iLBD were in the same direction and statistically significant, whereas for education, head injury, and number of children, they were in the same direction but not significant; they were in the opposite direction but not statistically significant for depression and anxiety. Incidental Lewy body disease was not associated with various end-of-life conditions or causes of death, though these patients were slightly older and more likely cachectic. Based on this exploratory study, iLBD and PD appear to have similar risk factor profiles. Thus, at least some cases of iLBD could represent preclinical PD, arrested PD, or a partial syndrome due to a lesser burden of causative factors. Incidental Lewy body disease is not explained by nonspecific end-of-life brain insults.

  11. Effects of Handling and Vehicle Injections on Adrenocorticotropic and Corticosterone Concentrations in Sprague–Dawley Compared with Lewis Rats

    Science.gov (United States)

    Deutsch-Feldman, Molly; Picetti, Roberto; Seip-Cammack, Katharine; Zhou, Yan; Kreek, Mary Jeanne

    2015-01-01

    The hypothalamic–pituitary–adrenal (HPA) axis is a key factor in the trajectory of the addiction-like cycle (a pattern of behavior characterized by escalating drug use, withdrawal, and relapse) in preclinical and clinical studies. Concentrations of HPA hormones change in laboratory animals in response to standard experimental procedures, including handling and vehicle injections. We compared HPA activity in adult male Lewis (inbred) and Sprague–Dawley (outbred) rats, 2 common strains in rodent models of addiction, after different schedules of handling and saline injections, to explore the extent to which HPA responses differ by strain and whether interindividual differences underlie addiction vulnerability. The 4 treatment conditions were no, short, or long handling and saline injections. In handled groups, rats were handled for 1 to 2 min for 3 times daily and were euthanized after 7 d (short handling) or 14 d (long handling). The injection schedule in the saline injection group mimicked that in a model of binge-like cocaine exposure. Across all treatment groups, concentrations of adrenocorticotropic hormone were higher in Sprague–Dawley than in Lewis rats. In Sprague–Dawley rats, corticosterone concentrations decreased after continued handling but remained constant in Lewis rats. Interindividual variability in hormone levels was greater in Sprague–Dawley than Lewis rats, although corticosterone variability decreased after continued handling. Prolactin did not differ between groups of either Sprague–Dawley and Lewis rats before or after handling. This study underscores the importance of prolonged handling before experimenter-provided drug-administration paradigms and of strain-associated differences that may affect study outcomes. PMID:25651089

  12. Effects of handling and vehicle injections on adrenocorticotropic and corticosterone concentrations in Sprague-Dawley compared with Lewis rats.

    Science.gov (United States)

    Deutsch-Feldman, Molly; Picetti, Roberto; Seip-Cammack, Katharine; Zhou, Yan; Kreek, Mary Jeanne

    2015-01-01

    The hypothalamic-pituitary-adrenal (HPA) axis is a key factor in the trajectory of the addiction-like cycle (a pattern of behavior characterized by escalating drug use, withdrawal, and relapse) in preclinical and clinical studies. Concentrations of HPA hormones change in laboratory animals in response to standard experimental procedures, including handling and vehicle injections. We compared HPA activity in adult male Lewis (inbred) and Sprague-Dawley (outbred) rats, 2 common strains in rodent models of addiction, after different schedules of handling and saline injections, to explore the extent to which HPA responses differ by strain and whether interindividual differences underlie addiction vulnerability. The 4 treatment conditions were no, short, or long handling and saline injections. In handled groups, rats were handled for 1 to 2 min for 3 times daily and were euthanized after 7 d (short handling) or 14 d (long handling). The injection schedule in the saline injection group mimicked that in a model of binge-like cocaine exposure. Across all treatment groups, concentrations of adrenocorticotropic hormone were higher in Sprague-Dawley than in Lewis rats. In Sprague-Dawley rats, corticosterone concentrations decreased after continued handling but remained constant in Lewis rats. Interindividual variability in hormone levels was greater in Sprague-Dawley than Lewis rats, although corticosterone variability decreased after continued handling. Prolactin did not differ between groups of either Sprague-Dawley and Lewis rats before or after handling. This study underscores the importance of prolonged handling before experimenter-provided drug-administration paradigms and of strain-associated differences that may affect study outcomes.

  13. Environmental monitoring at major U. S. Energy Research and Development Administration contractor sites: calendar year 1976. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    1977-08-01

    The purpose of this compilation is to present, in a central reference document, all of the individual annual reports summarizing the results of the environmental monitoring programs conducted at each of the Energy Research and Development Administration (ERDA) sites having a potential for environmental impact or which release a significant quantity of radioactivity or nonradioactive pollutants. Data on the levels of radioactivity and nonradioactive pollutants in effluents and the environs at each site are given, and effluent and environmental measurements and sampling results are evaluated in relation to the appropriate standards for environmental protection, including estimates of potential radiation exposures offsite. It is noteworthy that, in most cases, the potential offsite exposures are so low they cannot be determined by direct measurement methods but must be estimated by calculational techniques. All potential offsite exposures to members of the public from routine effluent releases in 1976 were less than 5 mrem/yr (i.e., less than one percent of the established radiation protection guidelines for exposure of the public). Additionally, the estimated collective man-rem dose potential to all members of the public within an 80 Km radius at all ERDA sites is less than .02 percent of the estimated man-rem dose due to natural and background environmental radiation.

  14. Researchers start complying with the requests of city administrators on earthquake risk issues: a recent case for Catania, Italy

    Science.gov (United States)

    Finazzi, D.; Frassine, L.; Pessina, V.

    2003-04-01

    Earthquake risk assessments and scenario studies carried out within national or European projects, not only have resonance in the research community, but they are becoming of increasing of interest for local administrators because of the detailed level of analysis and the nature of the results, that could be readily used. Notwithstanding their interest, the local administrators seem to have difficulties in transferring easily this kind of information into urban emergency plans. To overcome such difficulties, some damage prediction studies could be usefully re-focused on objectives that meet more directly the practical needs of city officials, such as identifying the streets that could be obstructed by the debris caused by the failure of damaged buildings in case of strong earthquakes. For Catania, a city in the Mediterranean with high exposure to earthquake risk, local operators have indicated a densely inhabited section with a critical ratio between the buildings elevation and the width of the roads. In this section, a damage scenario has been evaluated for residential buildings, considering also the strategic facilities such as schools, hospitals, city offices, together with the lifeline networks and the emergency shelter areas. The vulnerability assessment of the buildings involved is facilitated by the data gathered in a detailed recent survey (LSU survey), being now revisited and re-evaluated in the ongoing EC project RISK-UE. The ground shaking hazard has been estimated according to a deterministic scenario for an M7.2 earthquake occurring on a fault at some 12 km shortest distance from Catania. For the structures that are likely to collapse (and for those with predicted damage close to collapse), the volume of building debris has been estimated in order to quantify the fraction of it obstructing adjacent roads. Consequently, it is possible to identify the preferential escape routes to the emergency shelter areas. Different emergency levels could be

  15. Role of "external facilitation" in implementation of research findings: a qualitative evaluation of facilitation experiences in the Veterans Health Administration

    Directory of Open Access Journals (Sweden)

    Hagedorn Hildi

    2006-10-01

    Full Text Available Abstract Background Facilitation has been identified in the literature as a potentially key component of successful implementation. It has not, however, either been well-defined or well-studied. Significant questions remain about the operational definition of facilitation and about the relationship of facilitation to other interventions, especially to other change agent roles when used in multi-faceted implementation projects. Researchers who are part of the Quality Enhancement Research Initiative (QUERI are actively exploring various approaches and processes, including facilitation, to enable implementation of best practices in the Veterans Health Administration health care system – the largest integrated healthcare system in the United States. This paper describes a systematic, retrospective evaluation of implementation-related facilitation experiences within QUERI, a quality improvement program developed by the US Department of Veterans Affairs. Methods A post-hoc evaluation was conducted through a series of semi-structured interviews to examine the concept of facilitation across several multi-site QUERI implementation studies. The interview process is based on a technique developed in the field of education, which systematically enhances learning through experience by stimulating recall and reflection regarding past complex activities. An iterative content analysis approach relative to a set of conceptually-based interview questions was used for data analysis. Findings Findings suggest that facilitation, within an implementation study initiated by a central change agency, is a deliberate and valued process of interactive problem solving and support that occurs in the context of a recognized need for improvement and a supportive interpersonal relationship. Facilitation was described primarily as a distinct role with a number of potentially crucial behaviors and activities. Data further suggest that external facilitators were likely to use

  16. Relationship between vulnerability to reinforcing effects of morphine and activity of the endogenous cholecystokinin system in Lewis and Fischer rats.

    Science.gov (United States)

    Noble, Florence; Benturquia, Nadia; Crete, Dominique; Canestrelli, Corinne; Mas Nieto, Magdalena; Wilson, Jodie; Roques, Bernard P

    2012-05-01

    A great number of studies have shown the presence of physiological interactions between brain neurotransmitter systems in behavioural responses. This is the case for opioid, cholecystokinin (CCK) and dopamine systems. However, so far the role that the CCK system may play in vulnerability to consumption of drugs of abuse is not clear. This was investigated in this study using Lewis rats that are more sensitive to the reinforcing properties of drugs of abuse than Fischer rats. The extraneuronal CCK(8) levels and brain CCK(2) receptors were found higher in Fischer than in Lewis rats in the nucleus accumbens, one of the most important structures involved in drug consumption. Moreover, pharmacological modulation of the CCK system by administration of a selective CCK(2) agonist blocked, in the conditioned place preference, the reinforcing effects of morphine in Lewis rats, whereas a selective CCK(2) antagonist revealed reinforcing effects of the alkaloid in Fischer rats. These results obtained following systemic administrations of the CCK ligands were confirmed following microinjection into the nucleus accumbens. Thus, a low level of CCK efflux in the nucleus accumbens could be one of the many factors involved in drug reinforcing effects, whereas a high level of CCK efflux could attenuate it.

  17. A Comparative Career Profile in 1985-1990 Female and Male Graduates of Educational Administration from a Midwestern Research University.

    Science.gov (United States)

    Cunanan, Esmeralda S.

    In education, women are outnumbered by men four to one at the administrative level. This paper presents findings of a study that sought to determine the association between advanced degrees in educational administration and the careers of those holding such degrees. Data were obtained from questionnaires that were mailed to a total of 210 former…

  18. Sounds of silence : A research into the relationship between administrative supervision, criminal investigation and the nemo-tenetur principle

    NARCIS (Netherlands)

    Peçi, I.

    2006-01-01

    The subject of this thesis is the relationship between administrative supervision, criminal investigation and the nemo-tenetur principle. The point of departure is the distinction made in Dutch law and doctrine between administrative supervision and criminal investigation. Such a distinction is

  19. The Educational Context and Outcomes for High-School Students with Disabilities: The Perceptions of Administrators. Research Report.

    Science.gov (United States)

    Jones, Jennifer; Adams, Gary; Schumaker, Jean B.; Deshler, Donald D.; Davis, Betsy; Grossen, Bonnie; Bulgren, Janis A.; Marquis, Janet; Lenz, B. Keith

    The sixth in a series of studies investigating the educational context and outcomes for high school students with disabilities (SWDs), this study compared views of general education and special education administrators on the educational programs for SWDs and other at-risk students. Administrators in three high schools in urban areas, three in…

  20. Common Textbook and Teaching Misrepresentations of Lewis Structures

    Science.gov (United States)

    Suidan, Laila; Badenhoop, Jay K.; Glendening, Eric D.; Weinhold, Frank

    1995-07-01

    Current freshman chemistry textbooks commonly advise the drawing of Lewis structures with much emphasis on the reduction of formal charge and little on the preservation of the octet rule. This currently accepted method produces structures different from the original Lewis structures, which rarely had expanded valence shells on central atoms. Computational results from Gaussian 92 have shown us that the leading resonance structures cited in freshman chemistry textbooks are often not the most accurate to represent the molecules and are, at best, minor resonance structures, whose presentation is not worth the confusion that it causes for many first-year students. Instead, the Lewis structures that most accurately represent these molecules are the original Lewis structures, which generally abide by the octet rule. If the octet rule is more strongly stressed in the teaching of Lewis structures-thus avoiding the many complications and sources of confusion related to valence-shell expansion and reduction of formal charge-freshman chemistry students will be able to rest a little easier at night.

  1. Thierry Paquot, Lewis Mumford, Lewis Mumford. Pour une juste plénitude

    OpenAIRE

    Denoun, Martin

    2015-01-01

    La collection « Les précurseurs de la décroissance » des éditions du Passager clandestin s’étoffe rapidement et couvre une période historique très large, d’Épicure ou Lao-Tseu à Murray Bookchin ou André Gorz. L’objectif de la collection est de rendre visible la continuité de thématiques appelées aujourd’hui « décroissantes » chez des auteurs aux traditions a priori hétérogènes. Lewis Mumford, historien autodidacte des villes et des techniques, entre aujourd’hui dans cette bibliothèque décrois...

  2. The NASA Lewis Research Center Internal Fluid Mechanics Facility

    Science.gov (United States)

    Porro, A. R.; Hingst, W. R.; Wasserbauer, C. A.; Andrews, T. B.

    1991-01-01

    An experimental facility specifically designed to investigate internal fluid duct flows is described. It is built in a modular fashion so that a variety of internal flow test hardware can be installed in the facility with minimal facility reconfiguration. The facility and test hardware interfaces are discussed along with design constraints of future test hardware. The plenum flow conditioning approach is also detailed. Available instrumentation and data acquisition capabilities are discussed. The incoming flow quality was documented over the current facility operating range. The incoming flow produces well behaved turbulent boundary layers with a uniform core. For the calibration duct used, the boundary layers approached 10 percent of the duct radius. Freestream turbulence levels at the various operating conditions varied from 0.64 to 0.69 percent of the average freestream velocity.

  3. Experimental Studies of the Therapeutic Effect of Gypsophila Oldhamiana Gypsogenin on Lewis Lung Cancer in Mice

    Institute of Scientific and Technical Information of China (English)

    Guihong Tian; Ling Zhou; Ying Zhong; Wan Xu; Hong Bai; Lu Liu; Shuxiang Cui

    2008-01-01

    OBJECTIVE To observe the inhibitory effect of Gypsophila oldhamiana gypsogenin(GOG)on Lewis lung cancer growth,and to investiga te the mechanism of its anti-tumor effect.METHODS A mouse model bearing Lewis lung cancer was used.The 5 experimental groups were divided into a positive control(cis-diaminedichloroplatinum),a negative control,and high,medium and low-GOG dosage groups.The inhibitory action of GOG administration on the lung cancer was observed.After GOG treatment,the lungs were taken out and a lung coefficient computed.The expressions of VEGF,Bcl-2,Bax and P53 in the cancers were determined using immunohistochemical staining.RESULTS The tumor weight of the mice given various doses of GOG was significantly lower compared to the negative-control group(P<0.01),and the lung coefficient of the groups given high and low GOG doses was significantly lower compared to the negative-control group (P<0.01).Immunohistochemical results were shown as follows:I)The VEGF and Bcl-2 expressions in the GOG groups were significantly lower than that of the negativecontrol group(P<0.05);ii)Bax expression in the groups treated with high and medium GOG doses was significantly higher compared to the negative-control group(P<0.05);iii)The mutant P53 expression in the GOG-treated groups was significantly lower compared to the negative-control group (P<0.05).CONCLUSION GOG can inhibit the growth and metastasis of Lewis lung cancel and may exert its mechanism of tumor control by inhibition of tumor angiogenesis and induction of apoptosis.

  4. The Role of Naturalness in Lewis's Theory of Meaning

    Directory of Open Access Journals (Sweden)

    Brian Weatherson

    2013-05-01

    Full Text Available Many writers have held that in his later work, David Lewis adopted a theory of predicate meaning such that the meaning of a predicate is the most natural property that is (mostly consistent with the way the predicate is used. That orthodox interpretation is shared by both supporters and critics of Lewis's theory of meaning, but it has recently been strongly criticised by Wolfgang Schwarz. In this paper, I accept many of Schwarze's criticisms of the orthodox interpretation, and add some more. But I also argue that the orthodox interpretation has a grain of truth in it, and seeing that helps us appreciate the strength of Lewis's late theory of meaning.

  5. Development of a metastatic fluorescent Lewis Lung carcinoma mouse model

    DEFF Research Database (Denmark)

    Rask, Lene; Fregil, Marianne; Høgdall, Estrid;

    2013-01-01

    models. To examine the mechanisms involved in tumor metastasis, we first generated a stably transfected Lewis Lung carcinoma cell line expressing a far-red fluorescent protein, called Katushka. After in vivo growth in syngeneic mice, two fluorescent Lewis Lung cancer subpopulations were isolated from...... primary tumors and lung metastases. The metastasis-derived cells exhibited a significant improvement in in vitro invasive activity compared to the primary tumor-derived cells, using a quantitative invasion chamber assay. Moreover, expression levels of 84 tumor metastasis-related mRNAs, 88 cancer......-related microRNAs as well as Dicer and Drosha were determined using RT-qPCR. Compared to the primary Lewis Lung carcinoma subculture, the metastasis-derived cells exhibited statistically significantly increased mRNA levels for several matrix metalloproteinases as well as hepatocyte growth factor (HGF...

  6. Becoming a Researcher: A Reflection

    Science.gov (United States)

    Schoenfeld, Alan H.; Lewis, Katherine E.

    2016-01-01

    Viewed one way, Alan Schoenfeld's main lines of research and Katherine E. Lewis's dissertation have almost nothing in common. Schoenfeld work has focused on understanding mathematical thinking and teaching, while Lewis' work has focused on mathematical learning disabilities. Viewed another way, there are strong overlaps and strong parallels. In…

  7. Veterans Administration Databases

    Science.gov (United States)

    The Veterans Administration Information Resource Center provides database and informatics experts, customer service, expert advice, information products, and web technology to VA researchers and others.

  8. Lewis Acid Coupled Electron Transfer of Metal-Oxygen Intermediates.

    Science.gov (United States)

    Fukuzumi, Shunichi; Ohkubo, Kei; Lee, Yong-Min; Nam, Wonwoo

    2015-12-01

    Redox-inactive metal ions and Brønsted acids that function as Lewis acids play pivotal roles in modulating the redox reactivity of metal-oxygen intermediates, such as metal-oxo and metal-peroxo complexes. The mechanisms of the oxidative CH bond cleavage of toluene derivatives, sulfoxidation of thioanisole derivatives, and epoxidation of styrene derivatives by mononuclear nonheme iron(IV)-oxo complexes in the presence of triflic acid (HOTf) and Sc(OTf)3 have been unified as rate-determining electron transfer coupled with binding of Lewis acids (HOTf and Sc(OTf)3 ) by iron(III)-oxo complexes. All logarithms of the observed second-order rate constants of Lewis acid-promoted oxidative CH bond cleavage, sulfoxidation, and epoxidation reactions of iron(IV)-oxo complexes exhibit remarkably unified correlations with the driving forces of proton-coupled electron transfer (PCET) and metal ion-coupled electron transfer (MCET) in light of the Marcus theory of electron transfer when the differences in the formation constants of precursor complexes were taken into account. The binding of HOTf and Sc(OTf)3 to the metal-oxo moiety has been confirmed for Mn(IV) -oxo complexes. The enhancement of the electron-transfer reactivity of metal-oxo complexes by binding of Lewis acids increases with increasing the Lewis acidity of redox-inactive metal ions. Metal ions can also bind to mononuclear nonheme iron(III)-peroxo complexes, resulting in acceleration of the electron-transfer reduction but deceleration of the electron-transfer oxidation. Such a control on the reactivity of metal-oxygen intermediates by binding of Lewis acids provides valuable insight into the role of Ca(2+) in the oxidation of water to dioxygen by the oxygen-evolving complex in photosystem II. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Fugle og andre observationer på Lewis og Harris

    DEFF Research Database (Denmark)

    Provencal, Philippe

    2017-01-01

    En beskrivelse af observationer af især fugle men også nogle få pattedyr på øen Lewis and Harris i de Ydre Hebrider. Observationerne fandt sted fra den 19. til den 23- april 2017.......En beskrivelse af observationer af især fugle men også nogle få pattedyr på øen Lewis and Harris i de Ydre Hebrider. Observationerne fandt sted fra den 19. til den 23- april 2017....

  10. N-methylacridinium salts: carbon Lewis acids in frustrated Lewis pairs for σ-bond activation and catalytic reductions.

    Science.gov (United States)

    Clark, Ewan R; Ingleson, Michael J

    2014-10-13

    N-methylacridinium salts are Lewis acids with high hydride ion affinity but low oxophilicity. The cation forms a Lewis adduct with 4-(N,N-dimethylamino)pyridine but a frustrated Lewis pair (FLP) with the weaker base 2,6-lutidine which activates H2, even in the presence of H2O. Anion effects dominate reactivity, with both solubility and rate of H2 cleavage showing marked anion dependency. With the optimal anion, a N-methylacridinium salt catalyzes the reductive transfer hydrogenation and hydrosilylation of aldimines through amine-boranes and silanes, respectively. Furthermore, the same salt is active for the catalytic dehydrosilylation of alcohols (primary, secondary, tertiary, and ArOH) by silanes with no observable over-reduction to the alkanes. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Perceptions of academic administrators of the effect of involvement in doctoral programs on faculty members' research and work-life balance.

    Science.gov (United States)

    Smeltzer, Suzanne C; Sharts-Hopko, Nancy C; Cantrell, Mary Ann; Heverly, Mary Ann; Wise, Nancy; Jenkinson, Amanda

    2017-05-10

    Support for research strongly predicts doctoral program faculty members' research productivity. Although academic administrators affect such support, their views of faculty members' use of support are unknown. We examined academic administrators' perceptions of institutional support and their perceptions of the effects of teaching doctoral students on faculty members' scholarship productivity and work-life balance. An online survey was completed by a random sample of 180 deans/directors of schools of nursing and doctoral programs directors. Data were analyzed with descriptive statistics, chi-square analysis, and analysis of variance. Deans and doctoral program directors viewed the level of productivity of program faculty as high to moderately high and unchanged since faculty started teaching doctoral students. Deans perceived better administrative research supports, productivity, and work-life balance of doctoral program faculty than did program directors. Findings indicate the need for greater administrative support for scholarship and mentoring given the changes in the composition of doctoral program faculty. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Research on maritime administrative compulsory measures%海事行政强制措施研究

    Institute of Scientific and Technical Information of China (English)

    石钧

    2012-01-01

      Taking the seventeen administrative compulsory measures listed in the Provisions for Procedure of Maritime Administrative Compulsory Enforcement as examples, this article analyzes the traditional categories of maritime administrative compulsory measures and problems existed. Based on the principle of generality and particularity,it also puts forward suggestions on the scope of maritime administrative compulsory measures under the legal definition of Administrative Compulsory Enforcement Law.%  文中以《海事行政强制实施程序暂行规定》集中列举的17种传统行政强制措施为例,对传统海事行政强制措施的分类和存在问题加以分析,并以一般性与特殊性相结合的原则对《行政强制法》视角下海事行政强制措施的范围提出了建议。

  13. Lewis acid enhanced switching of the 1,1-dicyanodihydroazulene/vinylheptafulvene photo/thermoswitch

    DEFF Research Database (Denmark)

    Parker, Christian Richard; Tortzen, Christian Gregers; Broman, Søren Lindbæk

    2011-01-01

    Mild Lewis acids enhance the rate of the thermal conversion of vinylheptafulvene (VHF) to dihydroazulene (DHA). In the absence of light, stronger Lewis acids promote the otherwise photoinduced DHA to VHF conversion.......Mild Lewis acids enhance the rate of the thermal conversion of vinylheptafulvene (VHF) to dihydroazulene (DHA). In the absence of light, stronger Lewis acids promote the otherwise photoinduced DHA to VHF conversion....

  14. Further Research is Required to Determine Which Database Products Best Support Research in Public Administration. A review of: Tucker, James, Corey. “Database Support for Research in Public Administration.” Behavioral & Social Sciences Librarian 24.1 (2005: 47-60.

    Directory of Open Access Journals (Sweden)

    David Hook

    2006-06-01

    Full Text Available Objective – To examine the extent to which six commercial database products support student and faculty research in the area of public administration. Design – Bibliometric study. Setting – Academic library in the United States. Subjects – Six commercial business‐related database products were examined: Proquest’s ABI/INFORM Global edition (ABI, EBSCO’s Business Source Premier (BSP, Gale’s General BusinessFile ASAP (GBF, EBSCO’s Academic Search Premier (ASP, EBSCO’s Expanded Academic Index (EAI and Proquest’s International Academic Research Library (ARL. Three of the databases (ABI, BSP, GBF were chosen because they address the management, human resource, and financing elements of public administration. The other three (ASP, EAI, ARL were included because of their multidisciplinary coverage. Methods – A list of journal titles covering public administration was assembled from the Institute of Scientific Information’s Social Sciences Citation Index and previously published lists of recommended journals in the field. The author then compared the compiled list of journal titles against the journal titles indexed by the six database products. He further analyzed the results by level of journal coverage (abstract only, full‐text, and full‐text with embargo and subject area based on categories described in Ulrich’s Periodicals Directory. Main Results – The study found that three of the six database products ‐‐EAI, BSP, and ARL ‐‐ provide indexing for the greatest number of public administration journals contained in the compiled list. EIA and ARL cover the greatest number of those that are full‐text journals, while BSP and ASP cover the greatest number of those full‐text journals limited by publisher embargoes. Conclusion – The author concludes that of the six databases examined, EAI, BSP, and ARL are the best for public administration research, based on their strength in the subject areas of public

  15. Lewis acidic metal catalysed organic transformations by designed multi-component structures and assemblies

    Indian Academy of Sciences (India)

    Afsar Ali; Amit P Singh; Rajeev Gupta

    2010-05-01

    This paper presents the recent developments in designing multi-component structures including metal-organic frameworks containing Lewis acidic metal ions. The emphasis has been given to understand the design elements adopted to synthesize such structures bearing Lewis acidic metal ion. Further, few important Lewis acidic metal catalysed organic transformation reactions have been discussed demonstrating the importance of such materials for practical purposes.

  16. File list: Unc.Lng.50.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Lng.50.AllAg.Carcinoma,_Lewis_Lung mm9 Unclassified Lung Carcinoma, Lewis Lung ...http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.Lng.50.AllAg.Carcinoma,_Lewis_Lung.bed ...

  17. File list: Pol.Lng.05.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Lng.05.AllAg.Carcinoma,_Lewis_Lung mm9 RNA polymerase Lung Carcinoma, Lewis Lun...g http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.Lng.05.AllAg.Carcinoma,_Lewis_Lung.bed ...

  18. File list: Oth.Lng.20.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Lng.20.AllAg.Carcinoma,_Lewis_Lung mm9 TFs and others Lung Carcinoma, Lewis Lun...g http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.Lng.20.AllAg.Carcinoma,_Lewis_Lung.bed ...

  19. File list: Unc.Lng.10.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Lng.10.AllAg.Carcinoma,_Lewis_Lung mm9 Unclassified Lung Carcinoma, Lewis Lung ...http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.Lng.10.AllAg.Carcinoma,_Lewis_Lung.bed ...

  20. File list: Unc.Lng.05.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Lng.05.AllAg.Carcinoma,_Lewis_Lung mm9 Unclassified Lung Carcinoma, Lewis Lung ...http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.Lng.05.AllAg.Carcinoma,_Lewis_Lung.bed ...

  1. File list: His.Lng.20.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Lng.20.AllAg.Carcinoma,_Lewis_Lung mm9 Histone Lung Carcinoma, Lewis Lung SRX10...91778,SRX1091782,SRX1091785,SRX1091784,SRX1091781,SRX1091783,SRX1091780,SRX1091779 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Lng.20.AllAg.Carcinoma,_Lewis_Lung.bed ...

  2. File list: DNS.Lng.50.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.Lng.50.AllAg.Carcinoma,_Lewis_Lung mm9 DNase-seq Lung Carcinoma, Lewis Lung htt...p://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.Lng.50.AllAg.Carcinoma,_Lewis_Lung.bed ...

  3. File list: His.Lng.10.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Lng.10.AllAg.Carcinoma,_Lewis_Lung mm9 Histone Lung Carcinoma, Lewis Lung SRX10...91778,SRX1091782,SRX1091783,SRX1091779,SRX1091781,SRX1091784,SRX1091785,SRX1091780 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Lng.10.AllAg.Carcinoma,_Lewis_Lung.bed ...

  4. File list: Pol.Lng.50.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Lng.50.AllAg.Carcinoma,_Lewis_Lung mm9 RNA polymerase Lung Carcinoma, Lewis Lun...g http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.Lng.50.AllAg.Carcinoma,_Lewis_Lung.bed ...

  5. File list: Pol.Lng.20.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Lng.20.AllAg.Carcinoma,_Lewis_Lung mm9 RNA polymerase Lung Carcinoma, Lewis Lun...g http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.Lng.20.AllAg.Carcinoma,_Lewis_Lung.bed ...

  6. File list: Oth.Lng.10.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Lng.10.AllAg.Carcinoma,_Lewis_Lung mm9 TFs and others Lung Carcinoma, Lewis Lun...g http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.Lng.10.AllAg.Carcinoma,_Lewis_Lung.bed ...

  7. File list: DNS.Lng.20.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.Lng.20.AllAg.Carcinoma,_Lewis_Lung mm9 DNase-seq Lung Carcinoma, Lewis Lung htt...p://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.Lng.20.AllAg.Carcinoma,_Lewis_Lung.bed ...

  8. File list: His.Lng.05.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Lng.05.AllAg.Carcinoma,_Lewis_Lung mm9 Histone Lung Carcinoma, Lewis Lung SRX10...91778,SRX1091782,SRX1091783,SRX1091781,SRX1091784,SRX1091779,SRX1091785,SRX1091780 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Lng.05.AllAg.Carcinoma,_Lewis_Lung.bed ...

  9. File list: Oth.Lng.05.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Lng.05.AllAg.Carcinoma,_Lewis_Lung mm9 TFs and others Lung Carcinoma, Lewis Lun...g http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.Lng.05.AllAg.Carcinoma,_Lewis_Lung.bed ...

  10. File list: Unc.Lng.20.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Lng.20.AllAg.Carcinoma,_Lewis_Lung mm9 Unclassified Lung Carcinoma, Lewis Lung ...http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.Lng.20.AllAg.Carcinoma,_Lewis_Lung.bed ...

  11. File list: Pol.Lng.10.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Lng.10.AllAg.Carcinoma,_Lewis_Lung mm9 RNA polymerase Lung Carcinoma, Lewis Lun...g http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.Lng.10.AllAg.Carcinoma,_Lewis_Lung.bed ...

  12. File list: DNS.Lng.10.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.Lng.10.AllAg.Carcinoma,_Lewis_Lung mm9 DNase-seq Lung Carcinoma, Lewis Lung htt...p://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/DNS.Lng.10.AllAg.Carcinoma,_Lewis_Lung.bed ...

  13. File list: His.Lng.50.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Lng.50.AllAg.Carcinoma,_Lewis_Lung mm9 Histone Lung Carcinoma, Lewis Lung SRX10...91778,SRX1091782,SRX1091784,SRX1091780,SRX1091781,SRX1091785,SRX1091779,SRX1091783 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Lng.50.AllAg.Carcinoma,_Lewis_Lung.bed ...

  14. File list: Oth.Lng.50.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Lng.50.AllAg.Carcinoma,_Lewis_Lung mm9 TFs and others Lung Carcinoma, Lewis Lun...g http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.Lng.50.AllAg.Carcinoma,_Lewis_Lung.bed ...

  15. Frustrated Lewis pairs-assisted reduction of carbonyl compounds

    DEFF Research Database (Denmark)

    Marek, Ales; Pedersen, Martin Holst Friborg

    2015-01-01

    An alternative and robust method for the reduction of carbonyl groups by frustrated Lewis pairs (FLPs) is reported in this paper. With its very mild reaction conditions, good to excellent yields, absolute regioselectivity and the non-metallic character of the reagent, it provides an excellent too...

  16. Probability without certainty : foundationalism and the Lewis-Reichenbach debate

    NARCIS (Netherlands)

    Atkinson, David; Peijnenburg, Jeanne

    2006-01-01

    Like many discussions on the pros and cons of epistemic foundationalism, the debate between C. I. Lewis and H. Reichenbach dealt with three concerns: the existence of basic beliefs, their nature, and the way in which beliefs are related. In this paper we concentrate on the third matter, especially o

  17. Daniel Day-Lewis - veri peab voolama / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2008-01-01

    Iiri-juudi näitleja Daniel Day-Lewis, kes võitis oma rolliga P.T. Andersoni filmis "Veri hakkab voolama" parima meespeaosatäitja Oscari. Tema põhjalikust tööst rollidega läbi tema filmiloomingu

  18. Impact of Predatory Threat on Fear Extinction in Lewis Rats

    Science.gov (United States)

    Goswami, Sonal; Cascardi, Michele; Rodriguez-Sierra, Olga E.; Duvarci, Sevil; Pare, Denis

    2010-01-01

    Humans with post-traumatic stress disorder (PTSD) are deficient at extinguishing conditioned fear responses. A study of identical twins concluded that this extinction deficit does not predate trauma but develops as a result of trauma. The present study tested whether the Lewis rat model of PTSD reproduces these features of the human syndrome.…

  19. Sialyl Lewis x expression in cervical scrapes of premalignant lesions

    Indian Academy of Sciences (India)

    Noé Velázquez-Márquez; Gerardo Santos López; Lucio Jiménez Aranda; Julio Reyes Leyva; Verónica Vallejo Ruiz

    2012-12-01

    Sialylated oligosaccharides of glycoproteins and glycolipids have been implicated in tumour progression and metastases. Altered expression of glycosidic antigens has been reported in cervical cancer. In cervix premalignant lesions, an increased expression of sialic acid has been reported. In the present study we determined the expression profiles of the glycosidic antigens Tn, sialyl Tn (sTn), Lewis a (Lea), sialyl Lewis a (sLea), Lewis x (Lex) and sialyl Lewis x (sLex) in cervical scrapes with cytological diagnoses of normal, low-grade squamous intraepithelial lesions (LGSIL) and high-grade squamous intraepithelial lesions (HGSIL). Cervical scrapings were collected to detect tumour antigens expressions by flow cytometry using monoclonal antibodies. Cytometry analysis of Tn, sTn, Lea and Lex did not reveal differences at the expression level among groups. The number of positive cells to sLea antigen increased in the HGSIL group with respect to the normal group (=0.0495). The number of positive cells to sLex antigen in the samples increased with respect to the grade of squamous intraepithelial lesion (SIL) ( < 0.001, Mann–Whitney U test). The intensity of expression of this antigen increased in the HGSIL samples with respect to normal samples ( < 0.0068). sLex antigen could be a candidate to be used as biomarker for the early diagnosis of cervical cancer.

  20. Telling Lewis Hine's Story: Russell Freedman's "Kids at Work."

    Science.gov (United States)

    Zarnowski, Myra

    In "Kids at Work," Russell Freedman explores the world of child labor during the years 1908-1918 when Lewis Hine, "teacher-crusader," worked as an investigative photographer for the National Child Labor Committee (NCLC). Hine's writing and the photos he gathered from across the country revealed a "shocking reality that…

  1. Modified NASA-Lewis Chemical Equilibrium Code for MHD applications

    Energy Technology Data Exchange (ETDEWEB)

    Sacks, R. A.; Geyer, H. K.; Grammel, S. J.; Doss, E. D.

    1979-12-01

    A substantially modified version of the NASA-Lewis Chemical Equilibrium Code has recently been developed. The modifications were designed to extend the power and convenience of the Code as a tool for performing combustor analysis for MHD systems studies. This report describes the effect of the programming details from a user point of view, but does not describe the Code in detail.

  2. Probability without certainty : foundationalism and the Lewis-Reichenbach debate

    NARCIS (Netherlands)

    Atkinson, David; Peijnenburg, Jeanne

    Like many discussions on the pros and cons of epistemic foundationalism, the debate between C. I. Lewis and H. Reichenbach dealt with three concerns: the existence of basic beliefs, their nature, and the way in which beliefs are related. In this paper we concentrate on the third matter, especially

  3. Daniel Day-Lewis - veri peab voolama / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2008-01-01

    Iiri-juudi näitleja Daniel Day-Lewis, kes võitis oma rolliga P.T. Andersoni filmis "Veri hakkab voolama" parima meespeaosatäitja Oscari. Tema põhjalikust tööst rollidega läbi tema filmiloomingu

  4. Dr. Lewis Kitchener Dahl, the Dahl Rats and the ‘Inconvenient truth’ abou the Genetics of Hypertension

    Science.gov (United States)

    Joe, Bina

    2014-01-01

    Synopsis Lewis K. Dahl is regarded as an iconic figure in the field of hypertension research. During the 1960s and 1970s he published several seminal articles in the field that shed light on the relationship between salt and hypertension. Further, the Dahl rat models of hypertension that he developed by a selective breeding strategy are among the most widely used models for hypertension research. To this day, genetic studies using this model are ongoing in our laboratory. While Dr. Dahl is known for his contributions to the field of hypertension, very little, if any, of his personal history is documented. This article details a short biography of Dr. Lewis Dahl, the history behind the development of the Dahl rats and presents an overview of the results obtained through the genetic analysis of the Dahl rat as an experimental model to study the inheritance of hypertension. PMID:25646295

  5. Stress Alters the Discriminative Stimulus and Response Rate Effects of Cocaine Differentially in Lewis and Fischer Inbred Rats

    Directory of Open Access Journals (Sweden)

    Therese A. Kosten

    2012-03-01

    Full Text Available Stress enhances the behavioral effects of cocaine, perhaps via hypothalamic-pituitary-adrenal (HPA axis activity. Yet, compared to Fischer 344 (F344 rats, Lewis rats have hyporesponsive HPA axis function and more readily acquire cocaine self-administration. We hypothesized that stress would differentially affect cocaine behaviors in these strains. The effects of three stressors on the discriminative stimulus and response rate effects of cocaine were investigated. Rats of both strains were trained to discriminate cocaine (10 mg/kg from saline using a two-lever, food-reinforced (FR10 procedure. Immediately prior to cumulative dose (1, 3, 10 mg/kg cocaine test sessions, rats were restrained for 15-min, had 15-min of footshock in a distinct context, or were placed in the shock-paired context. Another set of F344 and Lewis rats were tested similarly except they received vehicle injections to test if stress substituted for cocaine. Most vehicle-tested rats failed to respond after stressor exposures. Among cocaine-tested rats, restraint stress enhanced cocaine’s discriminative stimulus effects in F344 rats. Shock and shock-context increased response rates in Lewis rats. Stress-induced increases in corticosterone levels showed strain differences but did not correlate with behavior. These data suggest that the behavioral effects of cocaine can be differentially affected by stress in a strain-selective manner.

  6. Rehabilitation-Related Research on Disability and Employer Practices Using Individual-Based National and Administrative Data Sets

    Science.gov (United States)

    Nazarov, Zafar E.; Erickson, William A.; Bruyère, Susanne M.

    2014-01-01

    Objective: It is useful to examine workplace factors influencing employment outcomes of individuals with disabilities and the interplay of disability, employment-related, and employer characteristics to inform rehabilitation practice. Design: A number of large national survey and administrative data sets provide information on employers and can…

  7. A Little More Madness in Our Methods? A Snapshot of How the Educational Leadership, Management and Administration Field Conducts Research

    Science.gov (United States)

    Thomson, Pat

    2017-01-01

    The field of educational leadership, management and administration (ELMA) uses methods drawn primarily from cognate educational disciplines. But does this matter? This paper explores the methods used in recently published papers through a snapshot of six issues of six ELMA journals. The analysis showed a preponderance of survey, interview and case…

  8. Women and Minorities in Administration. NAESP School Leadership Digest Series Number 11. ERIC/CEM Research Analysis Series, Number 13.

    Science.gov (United States)

    Coursen, David

    Literature on the role of women and minorities in school administration indicates that they both suffer from role stereotypes, although the stereotypes are somewhat different. Current literature on minority groups is limited almost entirely to discussion of blacks; the status of other racial minorities has been largely ignored. The role of blacks…

  9. A Citation-Based Ranking of German-Speaking Researchers in Business Administration with Data of Google Scholar

    Science.gov (United States)

    Dilger, Alexander; Müller, Harry

    2013-01-01

    Rankings of academics can be constructed in two different ways, either based on journal rankings or based on citations. Although citation-based rankings promise some fundamental advantages they are still not common in German-speaking business administration. However, the choice of the underlying database is crucial. This article argues that for…

  10. Research on the Cost of Government Administration%基于改善民生目标下降低政府行政成本的研究

    Institute of Scientific and Technical Information of China (English)

    林菡馨

    2012-01-01

    当前我国政府行政成本不断增长,已远远超过世界其他国家,因此对降低政府行政成本的研究不仅有利于提高政府行政效率、保障和改善民生,更有利于促进社会稳定及公平正义。根据对政府行政成本的分析,探讨造成行政成本较高的原因,提出绩效评估全面化、成本意识深入化、政府结构合理化、行政决策科学化来降低行政成本的具体措施。%The cost of government administration is increasing rapidly. So it's significant to start researching on decreasing the cost of government administration. Decrease of the cost of government administration will be beneficial for government to improve efficiency of administration and value people's live, even to attain social fairness and justice. Based on analysis of the cost of government administration, this paper puts forward several practical measures.

  11. A Thermodynamic and Kenetic Study of the Heterolytic Activation of Hydrogen by Frustrated Borane-Amine Lewis Pairs

    Energy Technology Data Exchange (ETDEWEB)

    Karkamkar, Abhijeet J.; Parab, Kshitij; Camaioni, Donald M.; Neiner, Doinita; Cho, Herman M.; Nielsen, Thomas K.; Autrey, Thomas

    2013-01-21

    Calorimetry is used to measure the reaction enthalpies of hydrogen activation by 2,6-lutidine (Lut), 2,2,6,6-tetramethylpiperidine (TMP), N-methyl-2,2,6,6-tetramethylpiperidine (MeTMP) and tri-tert-butylphosphine (TBP) with tris(pentafluorophenyl)borane (BCF). At 6.6 bar H2 the conversion of the Lewis acid Lewis base pair to the corresponding ionic pair in bromobenzene at 294 K was quantitative in under 60 minutes. Integration of the heat release from the reaction of the Frustrated Lewis Pair (FLP) with hydrogen as a function of time yields a relative rate of hydrogenation in addition to the enthalpy of hydrogenation. The half-lives of hydrogenation range from 230 seconds with TMP, ΔHH2 = -31.5(0.2) kcal/mol, to 1400 seconds with Lut, ΔHH2 = -23.4(0.4) kcal/mol. The 11B NMR spectrum of B(C6F5)3 in bromobenzene exhibits three distinct traits depending on the sterics of the Lewis base; (i) in the presence of pyridine, only the dative bond adduct pyridine--B(C6F5)3 is observed, (ii) in the presence of TMP and MeTMP only the free B(C6F5)3 is observed, and (iii) in the presence of Lut both the free B(C6F5)3 and the Lut--B(C6F5)3 adduct appear in equilibrium. A measure of the change in Keq of Lut + B(C6F5)3 <->Lut--B(C6F5)3 as a function of temperature provides thermodynamic properties of the Lewis acid Lewis base adduct, ΔH = -17.9(1.0) kcal/mol and a ΔS = -49.2(2.5) cal/mol K, suggesting the Lut--B(C6F5)3 adduct is more stable in bromobenzene than in toluene. This research was supported by the U.S. Department of Energy’s Basic Energy Sciences, Division of Chemical Sciences, Biosciences and Geosciences. D.M.C. and A.K. acknowledges support by the Laboratory Directed Research and Development program at the Pacific Northwest National Laboratory (PNNL) to perform kinetic analyses of the calorimetry data. The work was performed in part at EMSL, a national scientific user facility sponsored by the DOE Office of Biological and Environmental Research. EMSL is located at

  12. LRRK2 in Parkinson's disease and dementia with Lewy bodies

    Directory of Open Access Journals (Sweden)

    Zhu Xiongwei

    2006-11-01

    Full Text Available Abstract Background Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD. To examine whether LRRK2 is directly associated with neuropathology of PD and other related disorders, we analyzed LRRK2 in brains of patients affected by PD and dementia with Lewy bodies (DLB using highly specific antibodies to LRRK2. Results We demonstrated that anti-LRRK2 antibodies strongly labelled brainstem and cortical Lewy bodies, the pathological hallmarks of PD and DLB, respectively. In addition, anti-LRRK2 also labelled brain vasculature, axons, and neuronal cell bodies. Interestingly, the immunocytochemical profile of LRRK2 varied with different antibodies depending upon specific antigenic sites along the LRRK2 protein. All anti-LRRK2 antibodies tested that were raised against various regions of LRRK2, were found to be immunoreactive to recombinant LRRK2 on Western blots. However, only the antibodies raised against the N-terminal and C-terminal regions of LRRK2, but not the regions containing folded protein domains, were positive in immunolabeling of Lewy bodies, suggesting a differential exposure of specific antigenic sites of LRRK2 on tissue sections. Conclusion We conclude that LRRK2 is a component of Lewy bodies in both PD and DLB, and therefore plays an important role in the Lewy body formation and disease pathogenesis. Information on the cellular localization of LRRK2 under normal and pathological conditions will deepen our understanding of its functions and molecular pathways relevant to the progression of PD and related disorders.

  13. Comentarios sobre dos ensayos de sir Arthur Lewis

    Directory of Open Access Journals (Sweden)

    Currie Lauchlin

    1999-06-01

    Full Text Available

    Es un texto inédito del Profesor Lauchlin Currie, escrito en 1980 cuando todavía ocupaba su oficina en el Departamento Nacional de Planeación, En lo esencial, se trata de una crítica de algunos argumentos expuestos por Lewis en su breve libro
    The Evolution of the International Economic Order, publicado en inglés en 1978 y dos años más tarde en castellano por el Colegio de México. El problema central de este libro es el de por qué algunos países son ricos y otros son pobres. La respuesta de Lewis no dejó satisfecho al profesor Currie. A lo largo de este comentario, se observa un contrapunteo entre dos enfoques teóricos de la economía del desarrollo: la de Lewis -inicialmente expuesta en su celebre artículo sobre el desarrollo económico con oferta ilimitada de trabajo-que enfatiza la necesidad de generar un excedente agrícola como punto de partida del proceso; y la de Currie, que señala la posibilidad del crecimiento desequlibrado liderado por la actividad económica urbana, específicamente por el sector de la construcción. Aunque el profesor Currie destaca sus diferencias con Lewis, las conclusiones de ambos autores tienden a converger en torno de un punto que se resume en una frase del ensayo de Lewis, no citada en el comentario: "El motor del crecimiento debe ser el cambio tecnológico, y el comercio internacional debe servir como lubricante y no como combustible". Como bien señala el profesor Currie en su análisis, a la larga es irrelevante cuál sea el sector donde se presente ese cambio tecnológico.

  14. Developing Research Skills for Undergraduate Business Students: Experiential Learning on Introduction to Personnel Administration and Industrial Relations Course

    Science.gov (United States)

    Figueroa, Carmen I.; González, Cándida

    2014-01-01

    This paper reports on research into developing research skills in human resources management of apprentices through experiential learning. The target groups were undergraduate business students registered in the Introduction to Personnel and Industrial Relations course. The research identified the appreciation level of importance and satisfaction…

  15. Lewis Acids as Activators in CBS-Catalysed Diels-Alder Reactions: Distortion Induced Lewis Acidity Enhancement of SnCl4.

    Science.gov (United States)

    Nödling, Alexander R; Möckel, Robert; Tonner, Ralf; Hilt, Gerhard

    2016-09-05

    The effect of several Lewis acids on the CBS catalyst (named after Corey, Bakshi and Shibata) was investigated in this study. While (2) H NMR spectroscopic measurements served as gauge for the activation capability of the Lewis acids, in situ FT-IR spectroscopy was employed to assess the catalytic activity of the Lewis acid oxazaborolidine complexes. A correlation was found between the Δδ((2) H) values and rate constants kDA , which indicates a direct translation of Lewis acidity into reactivity of the Lewis acid-CBS complexes. Unexpectedly, a significant deviation was found for SnCl4 as Lewis acid. The SnCl4 -CBS adduct was much more reactive than the Δδ((2) H) values predicted and gave similar reaction rates to those observed for the prominent AlBr3 -CBS adduct. To rationalize these results, quantum mechanical calculations were performed. The frontier molecular orbital approach was applied and a good correlation between the LUMO energies of the Lewis acid-CBS-naphthoquinone adducts and kDA could be found. For the SnCl4 -CBS-naphthoquinone adduct an unusual distortion was observed leading to an enhanced Lewis acidity. Energy decomposition analysis with natural orbitals for chemical valence (EDA-NOCV) calculations revealed the relevant interactions and activation mode of SnCl4 as Lewis acid in Diels-Alder reactions. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.

    Science.gov (United States)

    McKeith, Ian G; Boeve, Bradley F; Dickson, Dennis W; Halliday, Glenda; Taylor, John-Paul; Weintraub, Daniel; Aarsland, Dag; Galvin, James; Attems, Johannes; Ballard, Clive G; Bayston, Ashley; Beach, Thomas G; Blanc, Frédéric; Bohnen, Nicolaas; Bonanni, Laura; Bras, Jose; Brundin, Patrik; Burn, David; Chen-Plotkin, Alice; Duda, John E; El-Agnaf, Omar; Feldman, Howard; Ferman, Tanis J; Ffytche, Dominic; Fujishiro, Hiroshige; Galasko, Douglas; Goldman, Jennifer G; Gomperts, Stephen N; Graff-Radford, Neill R; Honig, Lawrence S; Iranzo, Alex; Kantarci, Kejal; Kaufer, Daniel; Kukull, Walter; Lee, Virginia M Y; Leverenz, James B; Lewis, Simon; Lippa, Carol; Lunde, Angela; Masellis, Mario; Masliah, Eliezer; McLean, Pamela; Mollenhauer, Brit; Montine, Thomas J; Moreno, Emilio; Mori, Etsuro; Murray, Melissa; O'Brien, John T; Orimo, Sotoshi; Postuma, Ronald B; Ramaswamy, Shankar; Ross, Owen A; Salmon, David P; Singleton, Andrew; Taylor, Angela; Thomas, Alan; Tiraboschi, Pietro; Toledo, Jon B; Trojanowski, John Q; Tsuang, Debby; Walker, Zuzana; Yamada, Masahito; Kosaka, Kenji

    2017-07-04

    The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade. The revised DLB consensus criteria now distinguish clearly between clinical features and diagnostic biomarkers, and give guidance about optimal methods to establish and interpret these. Substantial new information has been incorporated about previously reported aspects of DLB, with increased diagnostic weighting given to REM sleep behavior disorder and (123)iodine-metaiodobenzylguanidine (MIBG) myocardial scintigraphy. The diagnostic role of other neuroimaging, electrophysiologic, and laboratory investigations is also described. Minor modifications to pathologic methods and criteria are recommended to take account of Alzheimer disease neuropathologic change, to add previously omitted Lewy-related pathology categories, and to include assessments for substantia nigra neuronal loss. Recommendations about clinical management are largely based upon expert opinion since randomized controlled trials in DLB are few. Substantial progress has been made since the previous report in the detection and recognition of DLB as a common and important clinical disorder. During that period it has been incorporated into DSM-5, as major neurocognitive disorder with Lewy bodies. There remains a pressing need to understand the underlying neurobiology and pathophysiology of DLB, to develop and deliver clinical trials with both symptomatic and disease-modifying agents, and to help patients and carers worldwide to inform themselves about the disease, its prognosis, best available treatments, ongoing research, and how to get adequate support. Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

  17. THE EFFECT OF PERSONALITY TRAITS ON LEADERSHIP BEHAVIORS: A RESEARCH ON THE STUDENTS OF BUSINESS ADMINISTRATION DEPARTMENT

    Directory of Open Access Journals (Sweden)

    Agah Sinan Ünsar

    2014-04-01

    Full Text Available In leadership definitions, it is generally approved that superior personality traits are one of the factors which form successful leadership. Furthermore, individuals follow leaders consistently and choose leaders as their role models. In this context; the purpose of this study is to investigate the effect of personality traits on leadership behaviors. Thus; a questionnaire has been implemented on the students of Trakya University Faculty of Economic and Administrative Sciences (FEAS and Vocational School of Social Sciences, Departments of Business Administration (Edirne-Turkey. Subsequently the findings have been commented by means of analyses and tables. Gender, grow-up places, educational level of students’ parents and types of high schools which students graduated from were found to affect the adopted leadership styles. Besides that, there are differences between the FEAS and the Vocational School students on extravert, responsible, open to experience personality traits and laissez-faire leadership style.

  18. Behavioral Public Administration : Combining Insights from Public Administration and Psychology

    OpenAIRE

    Grimmelikhuijsen, S.G.; Jilke, Sebastian; Leth Olsen, Asmus; Tummers, L.G.

    2016-01-01

    We propose behavioral public administration as a designated subfield in public administration which explicitly deals with the integration of theories and methods from psychology into the study of public administration. We discuss how scholars in public administration currently draw on both methodological and theoretical innovations in psychology and point to research questions in public administration which could benefit from further integration. Behavioral public administration cannot, and s...

  19. Behavioral Public Administration: Combining Insights from Public Administration and Psychology

    OpenAIRE

    2015-01-01

    We propose behavioral public administration as a designated subfield in public administration which explicitly deals with the integration of theories and methods from psychology into the study of public administration. We discuss how scholars in public administration currently draw on both methodological and theoretical innovations in psychology and point to research questions in public administration which could benefit from further integration. Behavioral public administration cannot, and s...

  20. The ABCs of the FDA: A Primer on the Role of the United States Food and Drug Administration in Medical Device Approvals and IR Research.

    Science.gov (United States)

    Adamovich, Ashley; Park, Susie; Siskin, Gary P; Englander, Meridith J; Mandato, Kenneth D; Herr, Allen; Keating, Lawrence J

    2015-09-01

    The role of the US Food and Drug Administration (FDA) in medical device regulation is important to device-driven specialties such as interventional radiology. Whether it is through industry-sponsored trials during the approval process for new devices or investigator-initiated research prospectively evaluating the role of existing devices for new or established procedures, interaction with the FDA is an integral part of performing significant research in interventional radiology. This article reviews the potential areas of interface between the FDA and interventional radiology, as understanding these areas is necessary to continue the innovation that is the hallmark of this specialty.

  1. Triazole-linked fluorescent bisboronic acid capable of selective recognition of the Lewis Y antigen.

    Science.gov (United States)

    Wang, Yan'en; Rong, Ruixue; Chen, Hua; Zhu, Mengyuan; Wang, Binghe; Li, Xiaoliu

    2017-05-01

    Cell surface carbohydrates of the Lewis blood group antigens, Lewis X (Le(x)), Lewis Y (Le(y)), Lewis A (Le(a)), and their sialylated derivatives, such as sialy Lewis X (sLe(x)) and sialy Lewis A (sLe(a)), play important roles in various recognition processes. These cell surface carbohydrates have also been associated with the development and progression of many types of cancers. Recently, we synthesized four anthracene-based fluorescent bisboronic acid sensors (compounds 2a-d) linked by 'click' chemistry with tethers of different lengths to match the epitope of various Lewis group of sugars. Among the four compounds, 2a appears to have both high sensitivity and selectivity for Le(y) among other carbohydrate antigens. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Nurturing educational research at Dartmouth Medical School: the synergy among innovative ideas, support faculty, and administrative structures.

    Science.gov (United States)

    Nierenberg, David W; Carney, Patricia A

    2004-10-01

    In recent years, Dartmouth Medical School has increased its commitment to educational research within the school, and in collaboration with other schools across the country. Passionate faculty members with ideas and expertise in particular curricular areas are one critical component needed for a successful educational research program. Other components include an atmosphere that fosters research collaborations and mentoring, and various types of institutional support structures. This same model has effectively supported basic science and clinical research for decades. Because of the complexities involved in studying medical education, Dartmouth Medical School has invested in support structures for educational grant and manuscript development, financial support for pilot projects and partial salary support for investigators and key staff members, and other support targeted toward specific research projects. Ultimately, the goal is to use the results of the school's educational research projects to improve the curriculum through cycles of hypothesis development and testing, providing evidence for subsequent curricular change. When some research findings are relevant and applicable for use in other medical schools, that is an additional benefit of the educational research process. In this report, the authors describe the development of Dartmouth Medical School's infrastructure for supporting educational research, which has helped to accelerate the educational research productivity teaching faculty now enjoy. The authors also address some of the challenges that they anticipate in the near future.

  3. The Subjects and Research Methodologies in Organizational Behavior Field: A Study on National Business Administration Congress Proceedings during 2010-2015

    Directory of Open Access Journals (Sweden)

    Seçkin Can Koyuncu

    2015-10-01

    Full Text Available This study aims to identify the tendencies about which subjects were mostly focused and which research methodologies were employed in the organizational behaviour studies over last six years, and explore the strengths and weakness of the studies in the field, and lastly give recommendations about future studies. In order to achieve this aim, I utilize content analysis on variables, research methodologies and data sources reported in the proceedings presented at National Business Administration Congresses during the years 2010-2015. As a result, it has been concluded that, in recent studies, leadership, job satisfaction, organizational commitment, performance and conflict were the mostly focused subjects. The present research indicated that 87.8% of the studies were quantitative studies and 5.3% of the studies were qualitative studies. In addition, 85.5% of the research applied survey methods and self-rating data collection method was used in 95.5% of these studies.

  4. Research Reviewed on Sports Administration Reform in China%关于我国体育行政改革的研究综述

    Institute of Scientific and Technical Information of China (English)

    王冰

    2011-01-01

    当前无论是国内还是国外,体育行政的讨论越来越受到重视,随着中国经济体制改革,特别是建立社会主义市场经济以来,中国体育行政开始发生了某种程度上的本质变化。本文分别从中央政府一级和地方政府一级的体育行政改革,以及体育行政职能方面对相关研究结果进行综述。%Whether domestic or abroad,the discussion of sports administration draws more and more attention in current.As China's economic system reforms,especially since the establishment of socialist market economy,the Chinese sports administration has occurred some extent essential changes.Related research results were reviewed respectively from the central government and the local government level of sports administration reform,as well as the functions of sports administration in this article.

  5. Theoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: a mini review.

    Science.gov (United States)

    Kuo, Andy; Smith, Maree T

    2014-08-15

    Clinically, central nervous system (CNS) disorders account for more hospitalisations and prolonged care than almost all other diseases combined. In the preclinical setting, the intracerebroventricular (ICV) route for cerebrospinal fluid (CSF) sampling or dose administration in rodent models of human CNS disorders has potential to provide key insight on the pathobiology of these conditions. Low level neuroinflammation is present in >40% of patients with severe depression or schizophrenia and so comparative assessment of CSF composition between patients and rodent models of CNS disorders is potentially invaluable for hypothesis generation and for assessing rodent model validity. As molecules in the CSF have relatively low protein binding and are freely exchanged into the extracellular fluid of the brain parenchyma, supraspinal drug administration into the CSF can produce therapeutic drug concentrations in the brain. Direct administration of investigational agents into the CSF of the lateral ventricle of the brain enables intrinsic efficacy and adverse effect profiles to be evaluated without the confounding effects of drug metabolism, due to the low capacity of the CNS to metabolise exogenous compounds. It is our view that the ICV route for CSF sampling and for administration of novel drugs in development is under-utilised in preclinical research on CNS disorders. This is due to the high degree of technical skill and low margin for error associated with correct ICV guide cannula implantation in the rat. However, these technical challenges can be overcome by using standardised procedures and attention to detail during surgery and in the post-operative period.

  6. An exploratory study of proficient undergraduate Chemistry II students' application of Lewis's model

    Science.gov (United States)

    Lewis, Sumudu R.

    This exploratory study was based on the assumption that proficiency in chemistry must not be determined exclusively on students' declarative and procedural knowledge, but it should be also described as the ability to use variety of reasoning strategies that enrich and diversify procedural methods. The study furthermore assumed that the ability to describe the structure of a molecule using Lewis's model and use it to predict its geometry as well as some of its properties is indicative of proficiency in the essential concepts of covalent bonding and molecule structure. The study therefore inquired into the reasoning methods and procedural techniques of proficient undergraduate Chemistry II students when solving problems, which require them to use Lewis's model. The research design included an original survey, designed by the researcher for this study, and two types of interviews, with students and course instructors. The purpose of the survey was two-fold. First and foremost, the survey provided a base for the student interview selection, and second it served as the foundation for the inquiry into the strategies the student use when solving survey problems. Twenty two students were interviewed over the course of the study. The interview with six instructors allowed to identify expected prior knowledge and skills, which the students should have acquired upon completion of the Chemistry I course. The data, including videos, audios, and photographs of the artifacts produced by students during the interviews, were organized and analyzed manually and using QSR NVivo 10. The research found and described the differences between proficient and non-proficient students' reasoning and procedural strategies when using Lewis's model to describe the structure of a molecule. One of the findings clearly showed that the proficient students used a variety of cues to reason, whereas other students used one memorized cue, or an algorithm, which often led to incorrect representations in

  7. From Bidentate Gallium Lewis Acids to Supramolecular Complexes.

    Science.gov (United States)

    Horstmann, Jan; Hyseni, Mentor; Mix, Andreas; Neumann, Beate; Stammler, Hans-Georg; Mitzel, Norbert W

    2017-05-22

    Bidentate gallium Lewis acids were prepared by the reaction of diethynyldiphenylsilane with neat trimethyl- or triethylgallium. Bis[(dimethylgallyl)ethynyl]diphenylsilane (1) and diethylgallyl derivative 2 were characterized as Et2 O or pyridine adducts by NMR spectroscopy; 2⋅2Py was isolated. Lewis acids 1 and 2 form host-guest adducts with bidentate nitrogen bases, but defined cyclic 1:1 adducts are only formed between 1 and bases with matching N⋅⋅⋅N distances: 4,4'-dimethyl-3,3'-bipyridinylacetylene (3), bis[(pyridin-3-yl)ethynyl]diphenylsilane (4), and bis[(2-methylpyridin-5-yl)ethynyl]diphenylsilane (5). The structures of adducts 1⋅3, 1⋅4, and 1⋅5 were established by X-ray diffraction experiments. 2⋅2Py reacts with DABCO to afford polymeric (DABCO-2-)n . © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Administrating Solr

    CERN Document Server

    Mohan, Surendra

    2013-01-01

    A fast-paced, example-based guide to learning how to administrate, monitor, and optimize Apache Solr.""Administrating Solr"" is for developers and Solr administrators who have a basic knowledge of Solr and who are looking for ways to keep their Solr server healthy and well maintained. A basic working knowledge of Apache Lucene is recommended, but this is not mandatory.

  9. 行政事业单位成本管理探析%Researches on Cost Management of Administrational Organizations

    Institute of Scientific and Technical Information of China (English)

    刘兰若

    2012-01-01

    行政事业单位的公共性、非营利性和财政性等特征决定了其在成本管理方面存在观念淡泊、成本内容不实、成本列支随意性强、成本开支结构不合理等问题,需要采取强化成本预算管理、加强采购管理、提高国有资产使用效率、完善内部控制制度和建立绩效考评制度等措施来解决。%The cost management of administrational organizations, with its specificity of public, nonprofit and administrational, would be needed to strengthen on its budget management, procurement management to enhance efficiency of national-owned cap- ital and improve internal controlling system and establish performance -efficiency evaluation system to resolve the problems that have existed in the cost management of the organizations.

  10. C.S.Lewis: The Chronicles of Narnia and imagination

    OpenAIRE

    Gojkošek, Monika

    2015-01-01

    The thesis entitled C. S. Lewis: The Chronicles of Narnia and imagination primarily focuses on the term fantastic novel, its development in Slovene literature and the definition of the term itself which changed during time. Since J. J. Kenda places The Chronicles of Narnia among fantasy literature a special emphasis is also given to the latter term. The second part of the thesis deals with the stories of The Chronicles of Narnia and the circumstances of their origin. An important part of the...

  11. Thermal degradation of polystyrene by Lewis acids in solution

    OpenAIRE

    2002-01-01

    The degradation of polystyrene in various Lewis acids [aluminum chloride, ferric chloride, borontriflouride etherate, and tin(IV) chloride] at different temperatures (75-125 degreesC) has been studied in this work. The evolution of the molecular weight distribution (MWD) has been modeled using continuous distribution kinetics with a stoichiometric kernel for random chain scission. The degradation rate was the highest in the presence of aluminum chloride. The reactions were also carried out at...

  12. Development of Fluorous Lewis Acid-Catalyzed Reactions

    Directory of Open Access Journals (Sweden)

    Joji Nishikido

    2006-08-01

    Full Text Available Organic synthetic methodology in the 21st century aims to conform to the principles of green sustainable chemistry (GSC and we may expect that in the future, the realization of GSC will be an important objective for chemical industries. An important aim of synthetic organic chemistry is to implement waste-free and environmentally-benign industrial processes using Lewis acids as versatile as aluminum choride. A key technological objective of our work in this area has been to achieve a “catalyst recycling system that utilizes the high activity and structural features of fluorous Lewis acid catalysts”. Thus, we have developed a series of novel fluorous Lewis acid catalysts, namely the ytterbium(III, scandium(III, tin(IV or hafnium(IV bis(perfluoroalkanesulfonylamides or tris(perfluoro- alkanesulfonylmethides. Our catalysts are recyclable and effective for acylations of alcohols and aromatics, Baeyer-Villiger reactions, direct esterifications and transesterifications in a fluorous biphasic system (FBS, in supercritical carbon dioxide and on fluorous silica gel supports.

  13. Lewis acidity enhancement of triarylborane by appended phosphine oxide groups.

    Science.gov (United States)

    Kwak, Jaewoo; Nghia, Nguyen Van; Lee, Junseong; Kim, Hyoseok; Park, Myung Hwan; Lee, Min Hyung

    2015-03-14

    A series of mono-, di-, and tri-phosphine oxide substituted triarylboranes, Mes2BAr (1), MesBAr2 (2), and BAr3 (3) (Ar = 4-(Ph2PO)-2,6-Me2-C6H2) were prepared to investigate the effect of a phosphine oxide group (Ph2PO) on Lewis acidity enhancement of triarylboranes. The X-ray crystal structure of 3 revealed peripheral decoration of Ph2PO groups with a C3-axis perpendicular to the trigonal boron center. UV/Vis absorption and PL spectra indicated a significant contribution of π(Mes or phenylene) → pπ(B) charge transfer in the lower-energy electronic transition. The reduction potential measured by cyclic voltammetry showed apparent LUMO stabilization by introduction of phosphine oxide groups, the extent of which gradually increased with the increasing number of phosphine oxide groups. Lewis acidity enhancement was also supported by the gradual increase in fluoride ion affinity in the order 3 > 2 > 1. Theoretical calculations suggest that introduction of a Ph2PO group into a triarylborane significantly enhances the Lewis acidity of the boron center via an inductive electron-withdrawing effect and this effect is additive for multiple phosphine oxide groups.

  14. Fullerene–Carbene Lewis Acid–Base Adducts

    KAUST Repository

    Li, Huaping

    2011-08-17

    The reaction between a bulky N-heterocylic carbene (NHC) and C60 leads to the formation of a thermally stable zwitterionic Lewis acid-base adduct that is connected via a C-C single bond. Low-energy absorption bands with weak oscillator strengths similar to those of n-doped fullerenes were observed for the product, consistent with a net transfer of electron density to the C60 core. Corroborating information was obtained using UV photoelectron spectroscopy, which revealed that the adduct has an ionization potential ∼1.5 eV lower than that of C60. Density functional theory calculations showed that the C-C bond is polarized, with a total charge of +0.84e located on the NHC framework and -0.84e delocalized on the C 60 cage. The combination of reactivity, characterization, and theoretical studies demonstrates that fullerenes can behave as Lewis acids that react with C-based Lewis bases and that the overall process describes n-doping via C-C bond formation. © 2011 American Chemical Society.

  15. Parkinson's disease dementia and dementia with Lewy bodies – epidemiology, risk factors and biomarkers

    Directory of Open Access Journals (Sweden)

    Eirik Auning

    2012-11-01

    Full Text Available Dementia with Lewy bodies (DLB and Parkinson's disease dementia (PDD are common and debilitating dementia syndromes accompanied by Parkinsonism and a range of other psychiatric, sleep and autonomic disturbances. Disease mechanisms are unknown, but aggregated Lewy bodies containing alpha-synuclein are believed to play a central role in the pathogenesis. Point-prevalence of dementia in Parkinson's disease (PD is approximately 30%, and the majority develop dementia as the disease progresses. Recent studies suggest that 25-30% of non-demented PD patients have mild cognitive impairment (MCI, and 15-20% already have it at the time of the diagnosis. PD-MCI is a strong predictor of PDD. There are few welldesigned epidemiological studies of DLB, but available evidence suggests that 15-20% of the total dementia population have DLB. Predicting future cognitive impairment is a priority, but the pre-dementia stage of DLB is essentially unexplored. Promising biomarkers are being researched, but, given the complexity of this disease, a multimodal approach is more likely to permit diagnostic precision in the future.

  16. Seeking out the sweet spot in cancer therapeutics: an interview with Lewis Cantley

    Directory of Open Access Journals (Sweden)

    2016-09-01

    Full Text Available Lewis C. Cantley, Director of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, is a world leader in cancer and metabolic disease research. His seminal discoveries have shed light on the regulation of ion pumps and other transport proteins, insulin-mediated regulation of glucose metabolism and the role of signal transduction networks in cell transformation. At Tufts University in the 1980s, Lewis and his collaborators unveiled and characterized the phosphoinositide 3-kinase (PI3K signaling pathway; a discovery that revolutionized the field of lipid signaling. In this interview, he documents his journey from serendipitous discovery of the pathway to determining its diverse physiological functions and role in cancer – an incredible odyssey that has laid the groundwork for clinical trials based on PI3K inhibitors. He also discusses the impact his early life had in spurring a thirst to understand biological processes at the molecular level, highlights how his multiple collaborations have helped in translating his basic discoveries to the clinic and explains why eating a high-sugar diet can be harmful. Ongoing studies in the Cantley lab are aimed at determining the mechanistic underpinnings of pancreatic, colorectal, ovarian and breast cancers, particularly the role of cellular metabolic pathways. The group has recently shown, amongst other breakthroughs, that vitamin C could provide a promising therapy for certain hard-to-treat cancers.

  17. Research

    African Journals Online (AJOL)

    ebutamanya

    4 mai 2016 ... L'antimoine, le chrome, le plomb et le cobalt se retrouvent élevés chez les malnutris et biens nourris. Le nickel est normal chez les malnutris et les biens nourris. ..... Liu J, Lewis G. Environmental toxicity and poor cognitive.

  18. Administrative Circulars

    CERN Multimedia

    Département des Ressources humaines

    2004-01-01

    Administrative Circular N° 2 (Rev. 2) - May 2004 Guidelines and procedures concerning recruitment and probation period of staff members This circular has been revised. It cancels and replaces Administrative Circular N° 2 (Rev. 1) - March 2000. Administrative Circular N° 9 (Rev. 3) - May 2004 Staff members contracts This circular has been revised. It cancels and replaces Administrative Circular N° 9 (Rev. 2) - March 2000. Administrative Circular N° 26 (Rev. 4) - May 2004 Procedure governing the career evolution of staff members This circular has also been revised. It Administrative Circulars Administrative Circular N° 26 (Rev. 3) - December 2001 and brings up to date the French version (Rev. 4) published on the HR Department Web site in January 2004. Operational Circular N° 7 - May 2004 Work from home This circular has been drawn up. Operational Circular N° 8 - May 2004 Dealing with alcohol-related problems...

  19. From genius inverts to gendered intelligence: Lewis Terman and the power of the norm.

    Science.gov (United States)

    Hegarty, Peter

    2007-05-01

    The histories of "intelligence" and "sexuality" have largely been narrated separately. In Lewis Terman's work on individual differences, they intersect. Influenced by G. Stanley Hall, Terman initially described atypically accelerated development as problematic. Borrowing from Galton, Terman later positioned gifted children as nonaverage but ideal. Attention to the gifted effeminate subjects used to exemplify giftedness and gender nonconformity in Terman's work shows the selective instantiation of nonaverageness as pathological a propos of effeminacy, and as ideal a propos of high intelligence. Throughout, high intelligence is conflated with health, masculinity, and heterosexuality. Terman's research located marital sexual problems in women's bodies, further undoing possibilities for evaluating heterosexual men's practices as different from a normative position. Terman's research modernized Galton's imperialist vision of a society lead by a male cognitive elite. Psychologists continue to traffic in his logic that values and inculcates intelligence only in the service of sexual and gender conformity.

  20. NASA Lewis Stirling SPRE testing and analysis with reduced number of cooler tubes

    Energy Technology Data Exchange (ETDEWEB)

    Wong, W.A.; Cairelli, J.E.; Swec, D.M.; Doeberling, T.J.; Lakatos, T.F. [National Aeronautics and Space Administration, Cleveland, OH (United States). Lewis Research Center; Madi, F.J. [Sverdrup Technology, Inc., Cleveland, OH (United States). Lewis Research Center Group

    1994-09-01

    Free-piston Stirling power converters are a candidate for high capacity space power applications. The Space Power Research Engine (SPRE), a free-piston Stirling engine coupled with a linear alternator, is being tested at the NASA Lewis Research Center in support of the Civil Space Technology Initiative. The SPRE is used as a test bed for evaluating converter modifications which have the potential to improve converter performance and for validating computer code predictions. Reducing the number of cooler tubes on the SPRE has been identified as a modification with the potential to significantly improve power and efficiency. This paper describes experimental tests designed to investigate the effects of reducing the number of cooler tubes on converter power, efficiency and dynamics. Presented are test results from the converter operating with a reduced number of cooler tubes and comparisons between this data and both baseline test data and computer code predictions.

  1. NASA Lewis Stirling SPRE testing and analysis with reduced number of cooler tubes

    Science.gov (United States)

    Wong, Wayne A.; Cairelli, James E.; Swec, Diane M.; Doeberling, Thomas J.; Lakatos, Thomas F.; Madi, Frank J.

    1992-08-01

    Free-piston Stirling power converters are candidates for high capacity space power applications. The Space Power Research Engine (SPRE), a free-piston Stirling engine coupled with a linear alternator, is being tested at the NASA Lewis Research Center in support of the Civil Space Technology Initiative. The SPRE is used as a test bed for evaluating converter modifications which have the potential to improve the converter performance and for validating computer code predictions. Reducing the number of cooler tubes on the SPRE has been identified as a modification with the potential to significantly improve power and efficiency. Experimental tests designed to investigate the effects of reducing the number of cooler tubes on converter power, efficiency and dynamics are described. Presented are test results from the converter operating with a reduced number of cooler tubes and comparisons between this data and both baseline test data and computer code predictions.

  2. Lewis acid catalyzed transformations of Z-ligustilide

    Energy Technology Data Exchange (ETDEWEB)

    Rios, Maria Yolanda [Universidad Autonoma del Estado de Morelos, Cuernavaca, Morelos (Mexico); Delgado, Guillermo [Universidad Nacional Autonoma de Mexico, Mexico, D.F. (Mexico)

    1999-08-01

    Some Lewis acid mediated reactions of Z-ligustilide (1), a bioactive constituent of the medicinal species Ligusticum porteri, were investigated. These reactions provided varying mixtures of Z-butylidenephthalide (7), E-butylidenephthalide (8), n-butyphthalide (13), and novel linear dimeric phthalides (9-12) as the main products. The formation of the dimers occurred in low yields and with regio and situ-selectivity. Initial competitive O- and C- complexation of the Lewis acid with Z-ligustilide promoted the formation of the dimers occurred in low yields and with regio and situ- selectivity. Initial competitive O- and C- complexation of the Lewis acid with Z-ligustilide promoted the formation of carbocations at C(8), C(6) and C(7), which were stabilized by the addition of the C(6')-C(7') olefin of a second unit of the starting material, to provide cations at C(6') and C(7'). Subsequent isomerizations and elimination of the catalyst afforded the dimeric products 9-12. The yields and structure of the products are quite dependent on variations of the reaction conditions and the catalyst employed. [Spanish] Se investigaron algunas reacciones de Z-ligustilidas (1), un constituyente bioactivo de la planta medicinal Ligusticum porteri, catalizadas por acidos de Lewis. Estas reacciones produjeron mezclas variables de Z-butilidenftalida (7), E-butilidenftalida (8), n-butilftalida (13), y ftalidos dimetricos lineales novedosos (9-12) como productos principales. La formacion de los dimeros procedio en rendimientos bajos y con regio- y situ-selectividad. La O- y C- complejacion competitiva inicial del acido de Lewis con Z-lingustilida promueve la formacion de cationes en C(8), C(6) y C(7), los cuales son estabilizados por la adicion de la olefina C(6')-C(7') de una segunda unidad de la materia prima para generar los cationes en C(6')-C(7'). Isomerizaciones subsecuentes y la eliminacion del catalizador conducen a los productos dimericos 9

  3. Brief history of the Office of Energy Research and Development: Federal Energy Office/Federal Energy Administration

    Energy Technology Data Exchange (ETDEWEB)

    Hibbard, W.R. Jr.

    1974-11-15

    A number of Important Issues in energy research and development which warrant special attention by the Energy Research and Development Office (ERDO) are identified and examined. Six matters considered to be of sufficient weight to be labeled Important Issues are: nuclear reactor siting policy: nuclear energy centers; the development of solar electric power; exploitation of western oil shale; improvements in mining technology for coal; assuring uranium fuel supplies; and automotive energy systems. The environmental issue is treated separately. Actions that ERDO can take to help resolve the issues are discussed.

  4. A Qualitative Research on the University Administrators' Capacity to Use Management Knowledge Tools (The Case of TRNC Universities)

    Science.gov (United States)

    Dagli, Gokmen; Silman, Fatos; Birol, Cem

    2009-01-01

    In order to reach goals and continue the ongoing learning process, like other organizations, universities also need the effective use of knowledge management. Knowledge management is an ongoing process and it has to be organized in a manner that is always open to new ideas. In universities where research and development studies play an important…

  5. The Wanderer, the Chameleon, and the Warrior: Experiences of Doctoral Students of Color Developing a Research Identity in Educational Administration

    Science.gov (United States)

    Murakami-Ramalho, Elizabeth; Piert, Joyce; Militello, Matthew

    2008-01-01

    In this article, the authors use their personal narratives and collaborative portraits as methods to shed light on the complexities of developing a research identity while journeying through a doctoral program. Using the metaphors of a wanderer, a chameleon, and a warrior, their narratives represent portraits of experiences faced by doctoral…

  6. Administrative Reform

    DEFF Research Database (Denmark)

    Plum, Maja

    Through the example of a Danish reform of educational plans in early childhood education, the paper critically addresses administrative educational reforms promoting accountability, visibility and documentation. Drawing on Foucaultian perspectives, the relation between knowledge and governing...... of administrative technology, tracing how the humanistic values of education embed and are embedded within ‘the professional nursery teacher' as an object and subject of administrative practice. Rather than undermining the humanistic potential of education, it is argued that the technology of accounting...

  7. 行政诉讼与民事诉讼交叉问题的探究%Research on the Overlapping Problems between Administrative Litigation and Civil Litigation

    Institute of Scientific and Technical Information of China (English)

    李婷

    2014-01-01

    Overlapping problems often appear between administrative litigation and civil litigation in judicial practice. How to handle these problems properly directly relates to the implementation of administrative organs in accordance with the law, the maintenance of judicial authority, the legitimate rights and interests of citizens, legal persons and other organizations. This paper researches ways to solve the overlapping problems between administrative litigation and civil litigation by analyzing one case.%行政诉讼中存在民事诉讼及民事诉讼中存在行政诉讼的行政诉讼与民事诉讼相互交叉问题常常会在在司法实践出现,对这一问题能否处理得当直接关系到能否保障行政机关依法行政,维护司法权威,使公民、法人及其他组织的合法权益得以保护。本文试通过对一起案件的分析探究处理行政诉讼与民事诉讼交叉问题的方法。

  8. Frustrated Lewis Pair Behavior of Intermolecular Annine/B(C6F5)(3) Pairs

    NARCIS (Netherlands)

    Voss, Tanja; Mahdi, Tayseer; Otten, Edwin; Froehlich, Roland; Kehr, Gerald; Stephan, Douglas W.; Erker, Gerhard

    2012-01-01

    Reactions of N,N-dimethylaniline, N-isopropyl-aniline, 1,4-C6H4(CH(2)NHtBu)(2), and benzyldimethylamine with the Lewis acid B(C6F5)(3) have been studied. In the case of N,N-dirnethylaniline the combination of the Lewis acid and base forms an almost completely noninteracting frustrated Lewis pair, wh

  9. Influence of Lewis Antigen Expression by Helicobacter pylori on Bacterial Internalization by Gastric Epithelial Cells

    OpenAIRE

    Lozniewski, Alain; Haristoy, Xavier; Rasko, David A.; Hatier, Renée; Plénat, François; Diane E Taylor; Angioi-Duprez, Karine

    2003-01-01

    The role of Helicobacter pylori lipopolysaccharide (LPS) Lewis antigens in infection is still not well known. We investigated the influence of Lewis antigen expression by H. pylori on its internalization by AGS cells and the epithelium of human gastric xenografts in nude mice using isogenic mutants in LPS biosynthetic genes. In vivo, colonization rates were unaffected by the change in H. pylori Lewis antigen expression, whereas the number of viable intracellular bacteria was significantly hig...

  10. The Use of a Satellite Communications System for Command and Control of the National Aeronautics and Space Administration Surrogate Unmanned Aerial System Research Aircraft

    Science.gov (United States)

    Howell, Charles T.; Jones, Frank; Hutchinson, Brian; Joyce, Claude; Nelson, Skip; Melum, Mike

    2017-01-01

    The NASA Langley Research Center has transformed a Cirrus Design SR22 general aviation (GA) aircraft into an Unmanned Aerial Systems (UAS) Surrogate research aircraft which has served for several years as a platform for unmanned systems research and development. The aircraft is manned with a Safety Pilot and a Research Systems Operator (RSO) that allows for flight operations almost any-where in the national airspace system (NAS) without the need for a Federal Aviation Administration (FAA) Certificate of Authorization (COA). The UAS Surrogate can be remotely controlled from a modular, transportable ground control station (GCS) like a true UAS. Ground control of the aircraft is accomplished by the use of data links that allow the two-way passage of the required data to control the aircraft and provide the GCS with situational awareness. The original UAS Surrogate data-link system was composed of redundant very high frequency (VHF) data radio modems with a maximum range of approximately 40 nautical miles. A new requirement was developed to extend this range beyond visual range (BVR). This new requirement led to the development of a satellite communications system that provided the means to command and control the UAS Surrogate at ranges beyond the limits of the VHF data links. The system makes use of the Globalstar low earth orbit (LEO) satellite communications system. This paper will provide details of the development, implementation, and flight testing of the satellite data communications system on the UAS Surrogate research aircraft.

  11. Administrative Ecology

    Science.gov (United States)

    McGarity, Augustus C., III; Maulding, Wanda

    2007-01-01

    This article discusses how all four facets of administrative ecology help dispel the claims about the "impossibility" of the superintendency. These are personal ecology, professional ecology, organizational ecology, and community ecology. Using today's superintendency as an administrative platform, current literature describes a preponderance of…

  12. The limits and robustness of reinforcement learning in Lewis signalling games

    Science.gov (United States)

    Catteeuw, David; Manderick, Bernard

    2014-04-01

    Lewis signalling games are a standard model to study the emergence of language. We introduce win-stay/lose-inaction, a random process that only updates behaviour on success and never deviates from what was once successful, prove that it always ends up in a state of optimal communication in all Lewis signalling games, and predict the number of interactions it needs to do so: N3 interactions for Lewis signalling games with N equiprobable types. We show three reinforcement learning algorithms (Roth-Erev learning, Q-learning, and Learning Automata) that can imitate win-stay/lose-inaction and can even cope with errors in Lewis signalling games.

  13. Lewis Carrol: la lógica de la imaginación

    OpenAIRE

    Cadavid, Jorge Hernando; Pontificia Universidad Javeriana, Bogotá

    2014-01-01

    Lewis Carroll es el seudónimo del autor de Alice 's Adventures in Wonderland! (Las aventuras de Alicia en el País de !as Maravillas), cyo nombre real era Charles Lutwidge Dodgson. El seudommo fue construido con los nombresde pila: Lutwidge-Lewis y Charles-Carroll (los tradujo primero al latín: Carolus yLudovico; invirtió el orden y volvió a traducirlos al inglés: Lewis Carroll). En verdad,Lewis Carroll era su alter ego: un domesticador de serpientes y sapos, prestidigitador(por arte de birlib...

  14. Direct catalytic asymmetric addition of allyl cyanide to ketones via soft Lewis acid/hard Brønsted base/hard Lewis base catalysis.

    Science.gov (United States)

    Yazaki, Ryo; Kumagai, Naoya; Shibasaki, Masakatsu

    2010-04-21

    We report that a hard Lewis base substantially affects the reaction efficiency of direct catalytic asymmetric gamma-addition of allyl cyanide (1a) to ketones promoted by a soft Lewis acid/hard Brønsted base catalyst. Mechanistic studies have revealed that Cu/(R,R)-Ph-BPE and Li(OC(6)H(4)-p-OMe) serve as a soft Lewis acid and a hard Brønsted base, respectively, allowing for deprotonative activation of 1a as the rate-determining step. A ternary catalytic system comprising a soft Lewis acid/hard Brønsted base and an additional hard Lewis base, in which the basicity of the hard Brønsted base Li(OC(6)H(4)-p-OMe) was enhanced by phosphine oxide (the hard Lewis base) through a hard-hard interaction, outperformed the previously developed binary soft Lewis acid/hard Brønsted base catalytic system, leading to higher yields and enantioselectivities while using one-tenth the catalyst loading and one-fifth the amount of 1a. This second-generation catalyst allows efficient access to highly enantioenriched tertiary alcohols under nearly ideal atom-economical conditions (0.5-1 mol % catalyst loading and a substrate molar ratio of 1:2).

  15. Structure of Flame Balls at Low Lewis-Number

    Science.gov (United States)

    Weiland, Karen J.; Ronney, Paul

    1998-01-01

    The Structure of Flame Balls at Low Lewis-Number (SOFBALL) experiment explored the behavior of a newly discovered flame phenomena called "flame balls." These spherical, stable, stationary flame structures, observed only in microgravity, provide a unique opportunity to study the interactions of the two most important processes necessary for combustion (chemical reaction and heat and mass transport) in the simplest possible configuration. The previously unobtainable experimental data provided a comparison with models of flame stability and flame propagation limits that are crucial both in assessing fire safety and in designing efficient, clean-burning combustion engines.

  16. Reduced CSF CART in dementia with Lewy bodies

    DEFF Research Database (Denmark)

    Schultz, Kristofer; Wiehager, Sara; Nilsson, Karin

    2009-01-01

    Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study......, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB...

  17. Feminine Hypostases in Epic Fantasy: Tolkien, Lewis, Rowling

    Directory of Open Access Journals (Sweden)

    Măcineanu Laura

    2015-12-01

    Full Text Available The paper identifies the types of female figures present in the works of three well-known fantasy writers, J.R.R. Tolkien, C.S. Lewis and J.K. Rowling, discussing the ways in which these characters are presented, their relationship with other characters, and their role in the economy of the novel, which is more important than may appear from a first reading. It also tries to explain the reasons that prompted the above-mentioned authors to choose these female hypostases.

  18. Surface Lewis acid-base properties of polymers measured by inverse gas chromatography.

    Science.gov (United States)

    Shi, Baoli; Zhang, Qianru; Jia, Lina; Liu, Yang; Li, Bin

    2007-05-18

    Surface Lewis acid-base properties are significant for polymers materials. The acid constant, K(a) and base constant, K(b) of many polymers were characterized by some researchers with inverse gas chromatography (IGC) in recent years. In this paper, the surface acid-base constants, K(a) and K(b) of 20 kinds of polymers measured by IGC in recent years are summarized and discussed, including seven polymers characterized in this work. After plotting K(b) versus K(a), it is found that the polymers can be encircled by a triangle. They scatter in two regions of the triangle. Four polymers exist in region I. K(b)/K(a) of the polymers in region I are 1.4-2.1. The other polymers exist in region II. Most of the polymers are relative basic materials.

  19. Cholinesterase inhibitors in Alzheimer's disease and Lewy body spectrum disorders: the emerging pharmacogenetic story

    Directory of Open Access Journals (Sweden)

    Lam Benjamin

    2009-12-01

    Full Text Available Abstract This review provides an update on the current state of pharmacogenetic research in the treatment of Alzheimer's disease (AD and Lewy body disease (LBD as it pertains to the use of cholinesterase inhibitors (ChEI. AD and LBD are first reviewed from clinical and pathophysiological perspectives. This is followed by a discussion of ChEIs used in the symptomatic treatment of these conditions, focusing on their unique and overlapping pharmacokinetic and pharmacodynamic profiles, which can be used to identify candidate genes for pharmacogenetics studies. The literature published to date is then reviewed and limitations are discussed. This is followed by a discussion of potential endophenotypes which may help to refine future pharmacogenetic studies of response and adverse effects to ChEIs.

  20. Personalized Cardiovascular Medicine Today: A Food and Drug Administration/Center for Drug Evaluation and Research Perspective.

    Science.gov (United States)

    Blaus, Alison; Madabushi, Rajanikanth; Pacanowski, Michael; Rose, Martin; Schuck, Robert N; Stockbridge, Norman; Temple, Robert; Unger, Ellis F

    2015-10-13

    Over the past decade, personalized medicine has received considerable attention from researchers, drug developers, and regulatory agencies. Personalized medicine includes identifying patients most likely to benefit and those most likely to experience adverse reactions in response to a drug, and tailoring therapy based on pharmacokinetics or pharmacodynamic response, as well. Perhaps most exciting is finding ways to identify likely responders through genetic, proteomic, or other tests, so that only likely responders will be treated. However, less precise methods such as identifying historical, demographic, or other indicators of increased or reduced responsiveness are also important aspects of personalized medicine. The cardiovascular field has not used many genetic or proteomic markers, but has regularly used prognostic variables to identify likely responders. The development of biomarker-based approaches to personalized medicine in cardiovascular disease has been challenging, in part, because most cardiovascular therapies treat acquired syndromes, such as acute coronary syndrome and heart failure, which develop over many decades and represent the end result of several pathophysiological mechanisms. More precise disease classification and greater understanding of individual variations in disease pathology could drive the development of targeted therapeutics. Success in designing clinical trials for personalized medicine will require the selection of patient populations with attributes that can be targeted or that predict outcome, and the use of appropriate enrichment strategies once such attributes are identified. Here, we describe examples of personalized medicine in cardiovascular disease, discuss its impact on clinical trial design, and provide insight into the future of personalized cardiovascular medicine from a regulatory perspective.

  1. Behavioral Public Administration: Combining Insights from Public Administration and Psychology

    DEFF Research Database (Denmark)

    Grimmelikhuijsen, Stephan; Jilke, Sebastian; Olsen, Asmus Leth

    2015-01-01

    We propose behavioral public administration as a designated subfield in public administration which explicitly deals with the integration of theories and methods from psychology into the study of public administration. We discuss how scholars in public administration currently draw on both......, behavioral public administration represents a two-way street in which public administration scholars use theories and methods from psychology, and psychologists, in turn, learn from our setting of political-administrative contexts to refine their theories and methods. Finally, we propose four principals...... methodological and theoretical innovations in psychology and point to research questions in public administration which could benefit from further integration. Behavioral public administration cannot, and should not, replace ‘conventional’ public administration, but it is complementary to it. Importantly...

  2. Special Administrative Jurisdictions

    Directory of Open Access Journals (Sweden)

    Vasilica Negruț

    2016-05-01

    Full Text Available The Constitution of Romania revised in 2003 establishes the free and voluntary nature of the special administrative jurisdictions, a fact which allows the party concerned to address either the administrative-judicial body or directly the court. If they opted for the administrative-judicial way, it must be followed to the end, then, under the terms established by the law, the party may address the court, under the right of access to justice provided by article 21 of the constitution. The administrative jurisdiction is an activity of solving an administrative litigation by specific procedural rules of judicial procedure, based on the principle of the independence, of insuring the right to defense and the administrative-jurisdictional independence activity, which results in a jurisdictional administrative act. In order to achieve the objectives of the paper, namely to highlight the essential elements of the resolution of litigation according to special administrative jurisdictions, we have achieved an analysis of the legislative acts referring to this activity, of the doctrine and jurisprudence. After examination and empirical research, the paper summarizes and specifies the general conclusions on the role and importance of special administrative courts.

  3. Lewis base activation of Lewis acids: catalytic, enantioselective addition of glycolate-derived silyl ketene acetals to aldehydes.

    Science.gov (United States)

    Denmark, Scott E; Chung, Won-Jin

    2008-06-20

    A catalytic system involving silicon tetrachloride and a chiral, Lewis basic bisphosphoramide catalyst is effective for the addition of glycolate-derived silyl ketene acetals to aldehydes. It was found that the sense of diastereoselectivity could be modulated by changing the size of the substituents on the silyl ketene acetals. In general, the trimethylsilyl ketene acetals derived from methyl glycolates with a large protecting group on the alpha-oxygen provide enantiomerically enriched alpha,beta-dihydroxy esters with high syn-diastereoselectivity, whereas the tert-butyldimethylsilyl ketene acetals derived from bulky esters of alpha-methoxyacetic acid provide enantiomerically enriched alpha,beta-dihydroxy esters with high anti-diastereoselecitvity.

  4. Offentlig administration

    DEFF Research Database (Denmark)

    Nielsen, Elof Nellemann; Rehr, Preben René

    En undervisningsbog der henvender sig til administrationsbacheloruddannelsen. Kapitlerne er inddelt efter modulerne på uddannelsen og indeholder derfor elementer af administration, forvaltning, økonomistyring, innovation, samfundsvidenskabelige metoder og politisk styrede organisationer.......En undervisningsbog der henvender sig til administrationsbacheloruddannelsen. Kapitlerne er inddelt efter modulerne på uddannelsen og indeholder derfor elementer af administration, forvaltning, økonomistyring, innovation, samfundsvidenskabelige metoder og politisk styrede organisationer....

  5. Michael Lewis: Flash Boys. Cracking the Money Code

    OpenAIRE

    Gylfi Magnússon

    2014-01-01

    Í umsögn gagnrýnanda kemur meðal annars eftirfarandi fram: Þegar á heildina er litið er þetta ágæt bók þótt hún sé ekki gallalaus. Lewis er ónákvæmur á köflum og dregur stundum upp helst til svart-hvíta mynd með því að viðra einungis hluta þeirra sjónarmiða sem máli skipta. Bókin vekur verðskuldaða athygli á ákveðnum skuggahliðum fjármálamarkaða sem full ástæða er til að gefa frekari gaum. Lewis tekst jafnframt að gæða söguna lífi með því að draga fram áhugaverðar persónur sem tengjast henni ...

  6. Michael Lewis: Flash Boys. Cracking the Money Code

    Directory of Open Access Journals (Sweden)

    Gylfi Magnússon

    2014-06-01

    Full Text Available Í umsögn gagnrýnanda kemur meðal annars eftirfarandi fram: Þegar á heildina er litið er þetta ágæt bók þótt hún sé ekki gallalaus. Lewis er ónákvæmur á köflum og dregur stundum upp helst til svart-hvíta mynd með því að viðra einungis hluta þeirra sjónarmiða sem máli skipta. Bókin vekur verðskuldaða athygli á ákveðnum skuggahliðum fjármálamarkaða sem full ástæða er til að gefa frekari gaum. Lewis tekst jafnframt að gæða söguna lífi með því að draga fram áhugaverðar persónur sem tengjast henni með ýmsum hætti.

  7. Lewis acid catalysis of a Diels-Alder reaction in water

    NARCIS (Netherlands)

    Otto, S; Bertoncin, F; Engberts, JBFN

    1996-01-01

    Here we report the first detailed study of a Diels-Alder (DA) reaction that is catalyzed by Lewis acids in water. The effect of Co2+, Ni2+, Cu2+ and Zn2+ ions as Lewis acid catalysts on the rate and endo-exo selectivity of the DA reaction between the bidentate dienophiles 3-phenyl-1-(2-pyridyl)-2-pr

  8. Catalytic Conversion of Glucose into 5-Hydroxymethylfurfural by Hf(OTf4 Lewis Acid in Water

    Directory of Open Access Journals (Sweden)

    Junjie Li

    2015-12-01

    Full Text Available A series of Lewis acidic metal salts were used for glucose dehydration to 5-hydroymethylfurfural (HMF in water. Effect of valence state, ionic radii of Lewis acidic cation, and the type of anions on the catalytic performance have been studied systematically. The experimental results showed that the valence state played an important role in determining catalytic activity and selectivity. It was found that a higher glucose conversion rate and HMF selectivity could be obtained over high valent Lewis acid salts, where the ionic radii of these Lewis acidic metal salts are usually relatively small. Analysis on the effect of the anions of Lewis acid salts on the catalytic activity and the selectivity suggested that a higher glucose conversion and HMF selectivity could be readily obtained with Cl−. Furthermore, the recyclability of high valence state Lewis acid salt was also studied, however, inferior catalytic performance was observed. The deactivation mechanism was speculated to be the fact that high valence state Lewis acid salt was comparatively easier to undergo hydrolysis to yield complicated metal aqua ions with less catalytic activity. The Lewis acidic activity could be recovered by introducing a stoichiometric amount of hydrochloric acid (HCl to the catalytic before the reaction.

  9. Lewis acid-catalyzed depolymerization of soda lignin in supercritical ethanol/water mixtures

    NARCIS (Netherlands)

    Güvenatam, Burcu; Heeres, Erik H.J.; Pidko, Evgeny A.; Hensen, Emiel J M

    2016-01-01

    The depolymerization of lignin model compounds and soda lignin by super Lewis acidic metal triflates has been investigated in a mixture of ethanol and water at 400 °C. The strong Lewis acids convert representative model compounds for the structure-forming linkages in lignin, namely α-O-4, 5-O-4

  10. Lewis acid catalysis of a Diels-Alder reaction in water

    NARCIS (Netherlands)

    Otto, S; Bertoncin, F; Engberts, JBFN

    1996-01-01

    Here we report the first detailed study of a Diels-Alder (DA) reaction that is catalyzed by Lewis acids in water. The effect of Co2+, Ni2+, Cu2+ and Zn2+ ions as Lewis acid catalysts on the rate and endo-exo selectivity of the DA reaction between the bidentate dienophiles

  11. Specific acid catalysis and Lewis acid catalysis of Diels–Alder reactions in aqueous media

    NARCIS (Netherlands)

    Mubofu, Egid B.; Engberts, Jan B.F.N.

    2004-01-01

    A comparative study of specific acid catalysis and Lewis acid catalysis of Diels–Alder reactions between dienophiles (1, 4 and 6) and cyclopentadiene (2) in water and mixed aqueous media is reported. The reactions were performed in water with copper(II) nitrate as the Lewis acid catalyst whereas

  12. Specific acid catalysis and Lewis acid catalysis of Diels-Alder reactions in aqueous media

    NARCIS (Netherlands)

    Mubofu, E.B.; Engberts, J.B.F.N.

    A comparative study of specific acid catalysis and Lewis acid catalysis of Diells-Alder reactions between dienophiles (1, 4 and 6) and cyclopentadiene (2) in water and mixed aqueous media is reported. The reactions were performed in water with copper(II) nitrate as the Lewis acid catalyst whereas

  13. An Integrated Perspective of Humanism and Supernaturalism for Education: C. S. Lewis's Version of Education

    Science.gov (United States)

    Lee, Seung Chun

    2013-01-01

    This paper explores some theoretical reflections on the connection between C. S. Lewis's thoughts on the purpose and process of education and his understanding of supernatural human nature which has been relatively little explored. An introduction about Lewis's career as a college teacher blends into the background of this paper. It is followed by…

  14. An Integrated Perspective of Humanism and Supernaturalism for Education: C. S. Lewis's Version of Education

    Science.gov (United States)

    Lee, Seung Chun

    2013-01-01

    This paper explores some theoretical reflections on the connection between C. S. Lewis's thoughts on the purpose and process of education and his understanding of supernatural human nature which has been relatively little explored. An introduction about Lewis's career as a college teacher blends into the background of this paper. It is followed by…

  15. Oral Interpretation of C.S. Lewis'"Narnia Tales": A Refracting of "Pictures."

    Science.gov (United States)

    Keefe, Carolyn

    "The Chronicles of Narnia" are a series of seven fairy tales written by C.S. Lewis that have become popular with both children and adults. Lewis points to five aspects of the fairy tale form that made the form suitable for expressing the images he saw. The aspects are: (1) no love interest; (2) no close psychology; (3) severe restraints…

  16. Specific acid catalysis and Lewis acid catalysis of Diels-Alder reactions in aqueous media

    NARCIS (Netherlands)

    Mubofu, E.B.; Engberts, J.B.F.N.

    2004-01-01

    A comparative study of specific acid catalysis and Lewis acid catalysis of Diells-Alder reactions between dienophiles (1, 4 and 6) and cyclopentadiene (2) in water and mixed aqueous media is reported. The reactions were performed in water with copper(II) nitrate as the Lewis acid catalyst whereas hy

  17. Specific acid catalysis and Lewis acid catalysis of Diels–Alder reactions in aqueous media

    NARCIS (Netherlands)

    Mubofu, Egid B.; Engberts, Jan B.F.N.

    2004-01-01

    A comparative study of specific acid catalysis and Lewis acid catalysis of Diels–Alder reactions between dienophiles (1, 4 and 6) and cyclopentadiene (2) in water and mixed aqueous media is reported. The reactions were performed in water with copper(II) nitrate as the Lewis acid catalyst whereas hyd

  18. Sentence Processing in Lewy Body Spectrum Disorder: The Role of Working Memory

    Science.gov (United States)

    Gross, Rachel G.; McMillan, Corey T.; Chandrasekaran, Keerthi; Dreyfuss, Michael; Ash, Sharon; Avants, Brian; Cook, Philip; Moore, Peachie; Libon, David J.; Siderowf, Andrew; Grossman, Murray

    2012-01-01

    Prior work has related sentence processing to executive deficits in non-demented patients with Parkinson's disease (PD). We extended this investigation to patients with dementia with Lewy bodies (DLB) and PD dementia (PDD) by examining grammatical and working memory components of sentence processing in the full range of patients with Lewy body…

  19. Reduced frequency of blood group Lewis a-b- in female Type 1 diabetes patients

    DEFF Research Database (Denmark)

    Kharagjitsingh, A.V.; Prinsen, K.; Lemkes, H.H.;

    2008-01-01

    AIMS: To examine a disputed association between the Lewis(a(-)b(-)) phenotype and Type 1 diabetes (T1D). METHODS: Lewis red blood cell phenotyping was performed for 97 T1D White patients and 100 control subjects using monoclonal antibodies. Two historical cohorts were also included as a control...

  20. Oral Interpretation of C.S. Lewis'"Narnia Tales": A Refracting of "Pictures."

    Science.gov (United States)

    Keefe, Carolyn

    "The Chronicles of Narnia" are a series of seven fairy tales written by C.S. Lewis that have become popular with both children and adults. Lewis points to five aspects of the fairy tale form that made the form suitable for expressing the images he saw. The aspects are: (1) no love interest; (2) no close psychology; (3) severe restraints…

  1. LewiSpace: An Exploratory Study with a Machine Learning Model in an Educational Game

    Science.gov (United States)

    Ghali, Ramla; Ouellet, Sébastien; Frasson, Claude

    2016-01-01

    The use of educational games as a tool for providing learners with a playful and educational aspect is widespread. In this paper, we present an educational game that we developed to teach a chemistry lesson, namely drawing a Lewis diagram. Our game is a 3D environment known as LewiSpace and aims at balancing between playful and educational…

  2. 行政伦理学研究方法论建构的若干问题%Some Issues on Constructing Research Methodology of Administrative Ethics

    Institute of Scientific and Technical Information of China (English)

    卢志雄

    2014-01-01

    当前行政伦理学研究主要有三种方法:思辨推论、历史研究和调研统计。本文认为依靠思辨推论进行研究与行政学探索客观规律的目的南辕北辙,事实上不可能得出确切结论;而后两种方法各有利弊,可以相互弥合补充。但还需要根据经验资料这一研究来源来具体分析研究中的难点,再立足行政伦理学理论架构,汲取管理学、历史学、统计学等相关学科的方法论研究成果,构建新的方法论框架。%Currently the administrative ethics mainly has three approaches:speculative reasoning , historical study , investi-gation and statistical research .The article emphasizes that speculative reasoning is just the reverse of the purpose of science of ad -ministration exploration , which in fact cannot draw any accurate conclusion .But historical study , investigation and statistical re-search have their advantages and disadvantages;moreover, they can complement each other .However, when doing the specific a-nalysis of the difficulties , we need the source of experience material , theoretical framework of administrative ethics and achievements of the methodology of the management , history, statistics and other related subjects in order to build a new framework for the meth-odology.

  3. Editorial Special issue on control theory and applications in honor of the 60th birthday of Professor Frank L. Lewis

    Institute of Scientific and Technical Information of China (English)

    Ben M.CHEN; Gang FENG

    2010-01-01

    @@ It is our great pleasure to put up this special issue in Journal of Control Theory and Applications in honor of the 60th birthday of Professor Frank Lewis, who has made many significant contributions to the field of control engineering through the years, and who is regarded as a pioneer in many areas in control and automation, which includes applied optimal control and geometric systems theory in his earlier research period, and his recent focus on intelligent nonlinear control, neural network feedback control, optimal control for nonlinear systems, H-infinity (game theory) control, approximate dynamic programming, discrete event supervisory control, intelligent diagnostics and prognostics, to name a few.

  4. 75 FR 55313 - Final Environmental Impact Statement (FEIS) for Grow the Army Actions at Fort Lewis and the...

    Science.gov (United States)

    2010-09-10

    ... Lewis-McChord, WA 98433-9500. FOR FURTHER INFORMATION CONTACT: Mr. Bill Van Hoesen, Joint Base Lewis- McChord National Environmental Policy Act (NEPA) Coordinator, at (253) 966-1780 during normal...

  5. Transcriptional network analysis in frontal cortex in Lewy body diseases with focus on dementia with Lewy bodies.

    Science.gov (United States)

    Santpere, Gabriel; Garcia-Esparcia, Paula; Andres-Benito, Pol; Lorente-Galdos, Belen; Navarro, Arcadi; Ferrer, Isidro

    2017-03-21

    The present study investigates global transcriptional changes in frontal cortex area 8 in incidental Lewy Body disease (iLBD), Parkinson disease (PD) and Dementia with Lewy bodies (DLB). We identified different co-expressed gene sets associated with disease stages, and gene ontology categories enriched in gene modules and differentially expressed genes including modules or gene clusters correlated to iLBD comprising upregulated dynein genes and taste receptors, and down-regulated innate inflammation. Focusing on DLB, we found modules with genes significantly enriched in functions related to RNA and DNA production, mitochondria and energy metabolism, purine metabolism, chaperone and protein folding system, and synapses and neurotransmission (particularly the GABAergic system). The expression of more than fifty selected genes was assessed with RT-qPCR. Our findings provide, for the first time, evidence of molecular cortical alterations in iLBD and involvement of several key metabolic pathways and gene hubs in DLB which may underlie cognitive impairment and dementia. This article is protected by copyright. All rights reserved.

  6. Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.

    Science.gov (United States)

    Toledo, Jon B; Gopal, Pallavi; Raible, Kevin; Irwin, David J; Brettschneider, Johannes; Sedor, Samantha; Waits, Kayla; Boluda, Susana; Grossman, Murray; Van Deerlin, Vivianna M; Lee, Edward B; Arnold, Steven E; Duda, John E; Hurtig, Howard; Lee, Virginia M-Y; Adler, Charles H; Beach, Thomas G; Trojanowski, John Q

    2016-03-01

    We investigated the distribution patterns of Lewy body-related pathology (LRP) and the effect of coincident Alzheimer disease (AD) pathology using a data-driven clustering approach that identified groups with different LRP pathology distributions without any diagnostic or researcher's input in two cohorts including: Parkinson disease patients without (PD, n = 141) and with AD (PD-AD, n = 80), dementia with Lewy bodies subjects without AD (DLB, n = 13) and demented subjects with AD and LRP pathology (Dem-AD-LB, n = 308). The Dem-AD-LB group presented two LRP patterns, olfactory-amygdala and limbic LRP with negligible brainstem pathology, that were absent in the PD groups, which are not currently included in the DLB staging system and lacked extracranial LRP as opposed to the PD group. The Dem-AD-LB individuals showed relative preservation of substantia nigra cells and dopamine active transporter in putamen. PD cases with AD pathology showed increased LRP. The cluster with occipital LRP was associated with non-AD type dementia clinical diagnosis in the Dem-AD-LB group and a faster progression to dementia in the PD groups. We found that (1) LRP pathology in Dem-AD-LB shows a distribution that differs from PD, without significant brainstem or extracranial LRP in initial phases; (2) coincident AD pathology is associated with increased LRP in PD indicating an interaction; (3) LRP and coincident AD pathology independently predict progression to dementia in PD, and (4) evaluation of LRP needs to acknowledge different LRP spreading patterns and evaluate substantia nigra integrity in the neuropathological assessment and consider the implications of neuropathological heterogeneity for clinical and biomarker characterization.

  7. Group dynamics in a long-term blind endeavor on Earth: An analog for space missions (Lewis & Clark Expedition group dynamic analysis)

    Science.gov (United States)

    Allner, M.; Rygalov, V.

    2008-12-01

    In 1803, President Thomas Jefferson set fourth a military expedition led by Captains M. Lewis and W. Clark (Lewis and Clark Expedition) on an exploration that would become an everlasting part of US national history and pride. Looking back at the events of this exploration, there are many similarities to the experiences future human space explorers will face as we look to colonize the Moon and travel to Mars and beyond (NASA Vision for Space Exploration, 2004): The Lewis and Clark Expedition lasted almost three years and involved a crew of 43 men traveling up the Missouri River to explore the unknown lands and a possible water route to the Pacific Ocean; The Expedition took place far away from customary comfortable environments known to European settlers in the early 18th century; The Expedition involved a remotely confined high-perceived risk environment with high levels of uncertainty providing stresses and every day challenges for the crew; Supplies brought on the mission were limited (mainly a mass/weight issue rather than cost), therefore the discovery and use of environmental resources (In-Situ Resource Utilization approach, including info-resources to mitigate uncertainty) was necessary for crew survival. The environments astronauts will encounter in space and on the Moon and Mars due to high risk and uncertainty will be in many aspects similar to what Lewis and Clark's crew experienced, as environments will be hostile and unforgiving if problems arise and aren't resolved quickly. The analysis provided in this research paper is relevant because the Lewis and Clark Expedition needed to move extensively and with minimal supplies. Polar remote settings, which were analyzed extensively, were different from this expedition due to the fact that these missions did not encompass extensive movement of crew facilities and supplies and were more like space missions orbiting the Earth. Using past space station results of performance on orbit in correlation with a

  8. Ransom, Religion, and Red Giants: C.S. Lewis and Fred Hoyle

    Science.gov (United States)

    Larsen, Kristine

    2010-01-01

    Famed fantasy writer C.S. Lewis (1898-1963) was known to friends as a well-read astronomy aficionado. However, this medieval scholar and Christian apologist embraced a pre-Copernican universe (with its astrological overtones) in his Chronicles of Narnia series and defended the beauty and relevance of the geocentric model in his final academic work, "The Discarded Image". In the "Ransom Trilogy” ("Out of the Silent Planet", "Perelandra", and "That Hideous Strength") philologist Ransom (loosely based on Lewis's close friend J.R.R. Tolkien) travels to Lewis's visions of Mars and Venus, where he interacts with intelligent extraterrestrials, battles with evil scientists, and aids in the continuation of extraterrestrial Christian values. In the final book, Ransom is joined by a handful of colleagues in open warfare against the satanic N.I.C.E. (National Institute for Coordinated Experiments). Geneticist and evolutionary biologist J.B.S. Haldane criticized Lewis for his scientifically inaccurate descriptions of the planets, and his disdain for the scientific establishment. Lewis responded to the criticism in essays of his own. Another of Lewis's favorite scientific targets was atheist Fred Hoyle, whom he openly criticized for anti-Christian statements in Hoyle's BBC radio series. Writer and Lewis friend Dorothy L. Sayers voiced her own criticism of Hoyle. In a letter, Lewis dismissed Hoyle as "not a great philosopher (and none of my scientific colleagues think much of him as a scientist.” Given Lewis's lack of respect for Hoyle, and use of creative license in describing the planets, and the flat-earth, "geocentric” Narnia, it is surprising that Lewis very carefully includes an astronomically correct description of red giants in two novels in the Narnia series ("The Magician's Nephew" and "The Last Battle"). This inclusion is even more curious given that Fred Hoyle is well-known as one of the pioneers in the field of stellar death and the properties of red giants.

  9. Interleukin-1 mediates Alzheimer and Lewy body pathologies

    Directory of Open Access Journals (Sweden)

    Liu Ling

    2006-03-01

    Full Text Available Abstract Background Clinical and neuropathological overlap between Alzheimer's (AD and Parkinson's disease (PD is now well recognized. Such cases of concurrent AD and Lewy body disease (AD/LBD show neuropathological changes that include Lewy bodies (α-synuclein aggregates, neuritic amyloid plaques, and neurofibrillary tangles (hyperphosphorylated tau aggregates. The co-occurrence of these clinical and neuropathological changes suggests shared pathogenic mechanisms in these diseases, previously assumed to be distinct. Glial activation, with overexpression of interleukin-1 (IL-1 and other proinflammatory cytokines, has been increasingly implicated in the pathogenesis of both AD and PD. Methods Rat primary cultures of microglia and cortical neurons were cultured either separately or as mixed cultures. Microglia or cocultures were treated with a secreted fragment (sAPPα of the β-amyloid precursor protein (βAPP. Neurons were treated with IL-1β or conditioned medium from sAPPα-activated microglia, with or without IL-1 receptor antagonist. Slow-release pellets containing either IL-1β or bovine serum albumin (control were implanted in cortex of rats, and mRNA for various neuropathological markers was analyzed by RT-PCR. Many of the same markers were assessed in tissue sections from human cases of AD/LBD. Results Activation of microglia with sAPPα resulted in a dose-dependent increase in secreted IL-1β. Cortical neurons treated with IL-1β showed a dose-dependent increase in sAPPα release, an effect that was enhanced in the presence of microglia. IL-1β also elevated the levels of α-synuclein, activated MAPK-p38, and phosphorylated tau; a concomitant decrease in levels of synaptophysin occurred. Delivery of IL-1β by slow-release pellets elevated mRNAs encoding α-synuclein, βAPP, tau, and MAPK-p38 compared to controls. Finally, human cases of AD/LBD showed colocalization of IL-1-expressing microglia with neurons that simultaneously

  10. NASA/FAA/NCAR Supercooled Large Droplet Icing Flight Research: Summary of Winter 1996-1997 Flight Operations

    Science.gov (United States)

    Miller, Dean; Ratvasky, Thomas; Bernstein, Ben; McDonough, Frank; Strapp, J. Walter

    1998-01-01

    During the winter of 1996-1997, a flight research program was conducted at the NASA-Lewis Research Center to study the characteristics of Supercooled Large Droplets (SLD) within the Great Lakes region. This flight program was a joint effort between the National Aeronautics and Space Administration (NASA), the National Center for Atmospheric Research (NCAR), and the Federal Aviation Administration (FAA). Based on weather forecasts and real-time in-flight guidance provided by NCAR, the NASA-Lewis Icing Research Aircraft was flown to locations where conditions were believed to be conducive to the formation of Supercooled Large Droplets aloft. Onboard instrumentation was then used to record meteorological, ice accretion, and aero-performance characteristics encountered during the flight. A total of 29 icing research flights were conducted, during which "conventional" small droplet icing, SLD, and mixed phase conditions were encountered aloft. This paper will describe how flight operations were conducted, provide an operational summary of the flights, present selected experimental results from one typical research flight, and conclude with practical "lessons learned" from this first year of operation.

  11. File list: InP.Lng.05.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Lng.05.AllAg.Carcinoma,_Lewis_Lung mm9 Input control Lung Carcinoma, Lewis Lung... http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Lng.05.AllAg.Carcinoma,_Lewis_Lung.bed ...

  12. File list: NoD.Lng.05.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Lng.05.AllAg.Carcinoma,_Lewis_Lung mm9 No description Lung Carcinoma, Lewis Lun...g http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.Lng.05.AllAg.Carcinoma,_Lewis_Lung.bed ...

  13. File list: NoD.Lng.20.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Lng.20.AllAg.Carcinoma,_Lewis_Lung mm9 No description Lung Carcinoma, Lewis Lun...g http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.Lng.20.AllAg.Carcinoma,_Lewis_Lung.bed ...

  14. File list: InP.Lng.20.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Lng.20.AllAg.Carcinoma,_Lewis_Lung mm9 Input control Lung Carcinoma, Lewis Lung... http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Lng.20.AllAg.Carcinoma,_Lewis_Lung.bed ...

  15. File list: InP.Lng.10.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Lng.10.AllAg.Carcinoma,_Lewis_Lung mm9 Input control Lung Carcinoma, Lewis Lung... http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Lng.10.AllAg.Carcinoma,_Lewis_Lung.bed ...

  16. File list: NoD.Lng.10.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Lng.10.AllAg.Carcinoma,_Lewis_Lung mm9 No description Lung Carcinoma, Lewis Lun...g http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.Lng.10.AllAg.Carcinoma,_Lewis_Lung.bed ...

  17. File list: InP.Lng.50.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Lng.50.AllAg.Carcinoma,_Lewis_Lung mm9 Input control Lung Carcinoma, Lewis Lung... http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.Lng.50.AllAg.Carcinoma,_Lewis_Lung.bed ...

  18. File list: NoD.Lng.50.AllAg.Carcinoma,_Lewis_Lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Lng.50.AllAg.Carcinoma,_Lewis_Lung mm9 No description Lung Carcinoma, Lewis Lun...g http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/NoD.Lng.50.AllAg.Carcinoma,_Lewis_Lung.bed ...

  19. Administration of Chemistry, Research Department

    African Journals Online (AJOL)

    KINETICS AND MECHANISM OF THE DIAZO COUPLING REACTION. OF ARENEDIAZO ..... by the transition state theory as v = k; I DEH" l fri / x .... d and M are the density and the molecular weight of dioxane or propan-2-ol, respectively, and x ...

  20. Administration of Chemistry, Research Department

    African Journals Online (AJOL)

    KINETICS AND MECHANISM OF THE DIAZO COU PLIHG REACTION. OF ARENEDIAZO ..... may be formulated by the transition state theory as .... d and M are the density and the molecular weight of dioxarie or propan-2-01, respectively, and ...

  1. Administration of Chemistry, Research Department

    African Journals Online (AJOL)

    rates of this acid catalyzed reaction in dioxane - water, ethanol - water, ... range of medium composition, at hydrochloric acid concentrations of 0.1 and 1 M. .... equation. mHA fHA fnzo =KSH+ mSH+ fSH+ ngo as + = KHA. 30 mA- fA— fS. (4).

  2. Database Administrator

    Science.gov (United States)

    Moore, Pam

    2010-01-01

    The Internet and electronic commerce (e-commerce) generate lots of data. Data must be stored, organized, and managed. Database administrators, or DBAs, work with database software to find ways to do this. They identify user needs, set up computer databases, and test systems. They ensure that systems perform as they should and add people to the…

  3. Database Administrator

    Science.gov (United States)

    Moore, Pam

    2010-01-01

    The Internet and electronic commerce (e-commerce) generate lots of data. Data must be stored, organized, and managed. Database administrators, or DBAs, work with database software to find ways to do this. They identify user needs, set up computer databases, and test systems. They ensure that systems perform as they should and add people to the…

  4. Differential Effects of Web-Based and Paper-Based Administration of Questionnaire Research Instruments in Authentic Contexts-of-Use

    Science.gov (United States)

    Hardre, Patricia L.; Crowson, H. Michael; Xie, Kui

    2010-01-01

    Questionnaire instruments are routinely translated to digital administration systems; however, few studies have compared the differential effects of these administrative methods, and fewer yet in authentic contexts-of-use. In this study, 326 university students were randomly assigned to one of two administration conditions, paper-based (PBA) or…

  5. Isolation and Characterization of Lewis Base Stabilized Monomeric Parent Stibanylboranes.

    Science.gov (United States)

    Marquardt, Christian; Hegen, Oliver; Hautmann, Matthias; Balázs, Gábor; Bodensteiner, Michael; Virovets, Alexander V; Timoshkin, Alexey Y; Scheer, Manfred

    2015-10-26

    The synthesis of the Lewis base stabilized monomeric parent compound of stibanylboranes, "H2 Sb-BH2 ", is reported. Through a salt metathesis route, the silyl-substituted compounds (Me3 Si)2 Sb-BH2 ⋅LB (LB=NMe3 , NHC(Me) ) were synthesized as representatives of derivatives with a Sb-B σ bond. Under very mild conditions, they could be transformed into the target compounds Me3 N⋅H2 B-HSb-BH2 ⋅NMe3 and H2 Sb-BH2 ⋅NHC(Me) , respectively. The products were characterized by X-ray structure analysis, NMR spectroscopy, IR spectroscopy, and mass spectrometry. DFT calculations give further insight into the stability and bonding of these unique compounds.

  6. Violence and mental illness: what Lewis Carroll had to say.

    Science.gov (United States)

    Torrey, E Fuller; Miller, Judy

    2014-12-01

    In 1873 Skeffington Lutwidge, a Lunacy Commission inspector of asylums in England, was killed by an asylum patient. Lutwidge was the uncle and close friend of Charles Lutwidge Dodgson, also known as Lewis Carroll. One year later, Carroll began writing The Hunting of the Snark, a poem whose meaning has mystified Carroll enthusiasts. In fact, the poem is a description of the Lunacy Commission inspection team and reflects Carroll's personal understanding of, and reaction to, the killing of his uncle by an individual with a severe mental illness. Carroll's close relationship with his uncle also explains the prominence of psychotic thinking in Carroll's work, including the Mad Hatter's tea party. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Lewy body dementia: the impact on patients and caregivers.

    Science.gov (United States)

    Zweig, Yael R; Galvin, James E

    2014-01-01

    Lewy body dementia (LBD) is the second most common neurodegenerative dementia in older adults, yet there remains a delay in diagnosis that limits healthcare providers' ability to maximize therapeutic outcomes and enhance patient and caregiver quality of life. The impact of LBD on patients includes limiting the potential exposure to medications that may cause adverse outcomes, and addressing how the disease manifestations, such as autonomic features and behavior, affect quality of life. LBD impact on caregivers has been discussed to a greater degree in the literature, and there is clear evidence of caregiver burden and grief associated with disease manifestations. Other common caregiving concerns, such as access to care, prevention of hospitalization, managing behavior, and reviewing prognosis and nursing home placement, are important to comprehensively address the needs of patients with LBD and their caregivers.

  8. [Diagnosis and treatment of multifocal motor neuropathy (Lewis-Sumner)].

    Science.gov (United States)

    Kaji, R

    1999-01-01

    We made a retrospective long-term follow-up study of 25 patients with multifocal motor neuropathy (Lewis-Sumner). The diagnosis was based upon criteria modified from those of AAEM (Sumner 1997). The electrophysiological findings indicating conduction block or focal demyelinative lesions were more diagnostic than anti-GM 1 antibody titers, which were elevated in only 40% of these patients. Demonstration of definite conduction block was not always possible in those patients who responded favorably to intravenous immunoglobulins (IVIg), whereas indirect pieces of evidence such as F-wave abnormalities or focal conduction delay or dispersion were equally helpful. IVIg had superior outcome to cyclophosphamide, which sometimes caused serious adverse effects. Three patients with severe axonal involvement showed elevated monospecific antibodies to GalNAc-GD1a.

  9. Teleparallel Energy-Momentum Distribution of Lewis-Papapetrou Spacetimes

    CERN Document Server

    Sharif, M

    2006-01-01

    In this paper, we find the energy-momentum distribution of stationary axisymmetric spacetimes in the context of teleparallel theory by using M$\\ddot{o}$ller prescription. The metric under consideration is the generalization of the Weyl metrics called the Lewis-Papapetrou metric. The class of stationary axisymmetric solutions of the Einstein field equations has been studied by Galtsov to include the gravitational effect of an {\\it external} source. Such spacetimes are also astrophysically important as they describe the exterior of a body in equilibrium. The energy density turns out to be non-vanishing and well-defined and the momentum becomes constant except along $\\theta$-direction. It is interesting to mention that the results reduce to the already available results for the Weyl metrics when we take $\\omega=0$.

  10. Teleparallel Energy-Momentum Distribution of Lewis-Papapetrou Spacetimes

    Science.gov (United States)

    Sharif, M.; Jamil Amir, M.

    In this paper, we find the energy-momentum distribution of stationary axisymmetric spacetimes in the context of teleparallel theory by using Möller prescription. The metric under consideration is the generalization of the Weyl metrics called the Lewis-Papapetrou metric. The class of stationary axisymmetric solutions of the Einstein field equations has been studied by Galtsov to include the gravitational effect of an external source. Such spacetimes are also astrophysically important as they describe the exterior of a body in equilibrium. The energy density turns out to be nonvanishing and well-defined and the momentum becomes constant except along θ-direction. It is interesting to mention that the results reduce to the already available results for the Weyl metrics when we take ω = 0.

  11. TRANSPOSICION DIDACTICA DEL MODELO CIENTIFICO DE LEWIS-LANGMUIR

    OpenAIRE

    Janneth Isabel Herreño Chaves; Rómulo Gallego Badillo; Royman Pérez Miranda

    2010-01-01

    Este artículo presenta las conclusiones obtenidas en un proyecto de investigación, en el que se auscultó la transposición didáctica que hacen del modelo de Lewis-Langmuir, diez de los textos para la enseñanza de la química más empleados por algunos profesores universitarios y de educación secundaria. Para el análisis se tuvo en cuenta lo histórico, lo epistemológico y lo didáctico. Los resultados muestran que en estos textos no hay referencia a la historia de la construcción del modelo y solo...

  12. Alcohol consumption, Lewis phenotypes, and risk of ischemic heart disease

    Energy Technology Data Exchange (ETDEWEB)

    Hein, H.O.; Suadicani, P.; Gyntelberg, F. (Rigshospitalet State Univ. Hospital, Copenhagen (Denmark). Epidemiological Research Unit); Sorenson, H. (Rigshospitalet State Univ. Hospital, Copenhagen (Denmark). Dept. of Chemical Immunology); Hein, H.O. (Univ. of Copenhagen (Denmark). Dept. of Internal Medicine)

    1993-02-13

    The authors have previously found an increased risk of ischemic heart disease (IHD) in men with the Lewis phenotype Le(a[minus]b[minus]) and suggested that the Lewis blood group has a close genetic relation with insulin resistance. The authors have investigated whether any conventional risk factors explain the increased risk in Le(a[minus]b[minus]) men. 3,383 men aged 53-75 years were examined in 1985-86, and morbidity and mortality during the next 4 years were recorded. At baseline, the authors excluded 343 men with a history of myocardial infarction, angina pectoris, intermittent claudication, or stroke. The potential risk factors examined were alcohol consumption, physical activity, tobacco smoking, serum cotinine, serum lipids, body-mass index, blood pressure, prevalence of hypertension and non-insulin-dependent diabetes mellitus, and social class. In 280 (9.6%) men with Le(a[minus]b[minus]), alcohol was the only risk factor significantly associated with risk of IHD. There was a significant inverse dose-effect relation between alcohol consumption and risk; trend tests, with adjustment for age, were significant for fatal IHD (p=0.02), all IHD (p=0.03), and all causes of death (p=0.02). In 2649 (90.4%) men with other phenotypes, there was a limited negative association with alcohol consumption. In Le(a[minus]b[minus]) men, a group genetically at high risk of IHD, alcohol consumption seems to be especially protective. The authors suggest that alcohol consumption may modify insulin resistance in Le(a[minus]b[minus]) men.

  13. Feminine Irony in the Religious Poetry of Gwyneth Lewis

    Directory of Open Access Journals (Sweden)

    Daniel SZABO

    2008-10-01

    Full Text Available Analyser l’ironie féminine dans la poésie d’une poète galloise écrivant en anglais semble en soi assez ironique pour un critique français. C’est pourquoi il paraît pertinent de faire appel à un autre critique français, Frédéric Regard, qui, dans La Force du Féminin, suggère que le féminin opère principalement dans l’ironie. L’ironie chez Gwyneth Lewis, première “National Poet” du Pays de Galles, est surprenante car elle est utilisée principalement en rapport à, ou même à l’encontre de, semble-t-il, de la religion comme pour mettre une distance avec le lecteur, avec le critique mais surtout une distance entre le poète et Dieu. Pourtant Lewis le confesse, elle se considère bien comme un (e poète religieux mais son ironie lui permet de s’affirmer en tant que poète travaillant sur et avec les mots tout en évitant tout sentimentalisme et en anticipant les critiques. Son ironie semble ainsi lui permettre petit à petit d’en venir à ce qui est selon elle l’objectif de son travail en tant que poète du sacré: faire l’éloge de Dieu.

  14. Moving From Discovery to System-Wide Change: The Role of Research in a Learning Health Care System: Experience from Three Decades of Health Systems Research in the Veterans Health Administration.

    Science.gov (United States)

    Atkins, David; Kilbourne, Amy M; Shulkin, David

    2017-01-11

    The Veterans Health Administration (VA) is unique, functioning as an integrated health care system that provides care to more than six million veterans annually and as a home to an established scientific enterprise that conducts more than $1 billion of research each year. The presence of research, spanning the continuum from basic health services to translational research, has helped the VA realize the potential of a learning health care system and has contributed to significant improvements in clinical quality over the past two decades. It has also illustrated distinct pathways by which research influences clinical care and policy and has provided lessons on challenges in translating research into practice on a national scale. These lessons are increasingly relevant to other health care systems, as the issues confronting the VA-the need to provide timely access, coordination of care, and consistent high quality across a diverse system-mirror those of the larger US health care system. Expected final online publication date for the Annual Review of Public Health Volume 38 is March 20, 2017. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

  15. Attenuation of salt-induced cardiac remodeling and diastolic dysfunction by the GPER agonist G-1 in female mRen2.Lewis rats.

    Directory of Open Access Journals (Sweden)

    Jewell A Jessup

    Full Text Available INTRODUCTION: The G protein-coupled estrogen receptor (GPER is expressed in various tissues including the heart. Since the mRen2.Lewis strain exhibits salt-dependent hypertension and early diastolic dysfunction, we assessed the effects of the GPER agonist (G-1, 40 nmol/kg/hr for 14 days or vehicle (VEH, DMSO/EtOH on cardiac function and structure. METHODS: Intact female mRen2.Lewis rats were fed a normal salt (0.5% sodium; NS diet or a high salt (4% sodium; HS diet for 10 weeks beginning at 5 weeks of age. RESULTS: Prolonged intake of HS in mRen2.Lewis females resulted in significantly increased blood pressure, mildly reduced systolic function, and left ventricular (LV diastolic compliance (as signified by a reduced E deceleration time and E deceleration slope, increased relative wall thickness, myocyte size, and mid-myocardial interstitial and perivascular fibrosis. G-1 administration attenuated wall thickness and myocyte hypertrophy, with nominal effects on blood pressure, LV systolic function, LV compliance and cardiac fibrosis in the HS group. G-1 treatment significantly increased LV lusitropy [early mitral annular descent (e'] independent of prevailing salt, and improved the e'/a' ratio in HS versus NS rats (P<0.05 as determined by tissue Doppler. CONCLUSION: Activation of GPER improved myocardial relaxation in the hypertensive female mRen2.Lewis rat and reduced cardiac myocyte hypertrophy and wall thickness in those rats fed a high salt diet. Moreover, these advantageous effects of the GPER agonist on ventricular lusitropy and remodeling do not appear to be associated with overt changes in blood pressure.

  16. BRAZILIAN ADMINISTRATION, ADMINISTRATIVE REFORM AND THE NEW STATE: THE ROLE OF ADMINISTRATIVE APPARATUS IN VARGAS ADMINISTRATION

    Directory of Open Access Journals (Sweden)

    Emerson Moura

    2016-07-01

    Full Text Available The role played by the administrative apparatus through the Department of Administrative Services in the Government policy Vargas is the object put in debate. Analyzes the theme from the the investigation of patrimonial, authoritarian and inefficient context which marks the formation and development of administrative bureaucracy, the tenders of professionalization and efficiency brought by the administrative reforms of the 1930s and 1940s with the contrast of the limitations of the import of the Weberian model in the Brazilian context and analysis of the establishment of the New State DASP and their assignments. Search the work demonstrate the control position he held directly and through the State Departments in the Brazilian Public Administration ensuring centralized and developmental policy of the government. For this is adopted as the research method of approach structuralism in order to identify the deconstruction of the phenomenon - of administrative reforms - in the superficial perception - the proposed impersonality and efficiency as the best way of achieving the public interest - its invariant structure - the search for the adequacy of the administrative apparatus and bureaucracy for pursuit of political ends pursued by the Government.

  17. Chemoselective Lewis pair polymerization of renewable multivinyl-functionalized γ-butyrolactones

    Science.gov (United States)

    Gowda, Ravikumar R.; Chen, Eugene Y.-X.

    2017-07-01

    Multivinyl-functionalized γ-butyrolactones, γ-vinyl-γ-methyl-α-methylene-γ-butyrolactone (γVMMBL) and γ-allyl-γ-methyl-α-methylene-γ-butyrolactone (γAMMBL), have been synthesized from biorenewable ethyl levulinate and effectively polymerized by Lewis pairs consisting of an organic N-heterocyclic carbene Lewis base and a strong organo-Lewis acid E(C6F5)3 (E = Al, B). This Lewis pair polymerization is quantitatively chemoselective, proceeds exclusively via polyaddition across the conjugated α-methylene double bond without participation of the γ-vinyl or γ-allyl double bond, and produces high-molecular-weight functionalized polymers with unimodal molecular-weight distributions. The Al-based Lewis pair produces a polymer with approximately 5.5 times higher molecular weight than that produced by the B-based Lewis pair. The resulting vinyl-functionalized polymers are soluble in common organic solvents and stable at room temperature, and can be thermally cured into crosslinked materials. This article is part of the themed issue 'Frustrated Lewis pair chemistry'.

  18. Role of the ABO, Secretor, and Lewis determinants in the primed lymphocyte test.

    Science.gov (United States)

    Singal, D P; Blajchman, M A; Naipaul, N; Joseph, S

    1981-05-01

    The antigenic determinants of the combined ABO, Lewis, and Secretor genes have been detected on the surface of lymphocytes by the lymphocytotoxicity test. We have studied the role of these determinants in the primed lymphocyte test (PLT), and the data demonstrate that Lewis incompatibility causes proliferative responses in PLT. On the other hand, no effects of ABO and Secretor incompatibilities were observed in this test. The frequency of the alloantigen-reactive cells (ARC) responding to Lewis and HLA-DR antigens in PLT was estimated by the limiting dilution analysis. The frequency of ARC to allogeneic Lewis-negative donors, who are positive for the sensitizing HLA-DR antigens ranged between 1:58 and 1:97. The incidence of ARC to Lewis-positive allogeneic donors who did not carry the sensitizing HLA-DR specificity was 1:94 to 1:142. These results demonstrate the presence of lymphocyte clones that are able to respond to antigens of the Lewis system. This study suggests that non-HLA antigens belonging to the Lewis system can cause stimulation of lymphocytes in the PLT test.

  19. Lewis pair polymerization by classical and frustrated Lewis pairs: acid, base and monomer scope and polymerization mechanism.

    Science.gov (United States)

    Zhang, Yuetao; Miyake, Garret M; John, Mallory G; Falivene, Laura; Caporaso, Lucia; Cavallo, Luigi; Chen, Eugene Y-X

    2012-08-14

    Classical and frustrated Lewis pairs (LPs) of the strong Lewis acid (LA) Al(C(6)F(5))(3) with several Lewis base (LB) classes have been found to exhibit exceptional activity in the Lewis pair polymerization (LPP) of conjugated polar alkenes such as methyl methacrylate (MMA) as well as renewable α-methylene-γ-butyrolactone (MBL) and γ-methyl-α-methylene-γ-butyrolactone (γ-MMBL), leading to high molecular weight polymers, often with narrow molecular weight distributions. This study has investigated a large number of LPs, consisting of 11 LAs as well as 10 achiral and 4 chiral LBs, for LPP of 12 monomers of several different types. Although some more common LAs can also be utilized for LPP, Al(C(6)F(5))(3)-based LPs are far more active and effective than other LA-based LPs. On the other hand, several classes of LBs, when paired with Al(C(6)F(5))(3), can render highly active and effective LPP of MMA and γ-MMBL; such LBs include phosphines (e.g., P(t)Bu(3)), chiral chelating diphosphines, N-heterocyclic carbenes (NHCs), and phosphazene superbases (e.g., P(4)-(t)Bu). The P(4)-(t)Bu/Al(C(6)F(5))(3) pair exhibits the highest activity of the LP series, with a remarkably high turn-over frequency of 9.6 × 10(4) h(-1) (0.125 mol% catalyst, 100% MMA conversion in 30 s, M(n) = 2.12 × 10(5) g mol(-1), PDI = 1.34). The polymers produced by LPs at RT are typically atactic (P(γ)MMBL with ∼47% mr) or syndio-rich (PMMA with ∼70-75% rr), but highly syndiotactic PMMA with rr ∼91% can be produced by chiral or achiral LPs at -78 °C. Mechanistic studies have identified and structurally characterized zwitterionic phosphonium and imidazolium enolaluminates as the active species of the current LPP system, which are formed by the reaction of the monomer·Al(C(6)F(5))(3) adduct with P(t)Bu(3) and NHC bases, respectively. Kinetic studies have revealed that the MMA polymerization by the (t)Bu(3)P/Al(C(6)F(5))(3) pair is zero-order in monomer concentration after an initial

  20. Lewis pair polymerization by classical and frustrated Lewis pairs: Acid, base and monomer scope and polymerization mechanism

    KAUST Repository

    Zhang, Yuetao

    2012-01-01

    Classical and frustrated Lewis pairs (LPs) of the strong Lewis acid (LA) Al(C 6F 5) 3 with several Lewis base (LB) classes have been found to exhibit exceptional activity in the Lewis pair polymerization (LPP) of conjugated polar alkenes such as methyl methacrylate (MMA) as well as renewable α-methylene-γ-butyrolactone (MBL) and γ-methyl- α-methylene-γ-butyrolactone (γ-MMBL), leading to high molecular weight polymers, often with narrow molecular weight distributions. This study has investigated a large number of LPs, consisting of 11 LAs as well as 10 achiral and 4 chiral LBs, for LPP of 12 monomers of several different types. Although some more common LAs can also be utilized for LPP, Al(C 6F 5) 3-based LPs are far more active and effective than other LA-based LPs. On the other hand, several classes of LBs, when paired with Al(C 6F 5) 3, can render highly active and effective LPP of MMA and γ-MMBL; such LBs include phosphines (e.g., P tBu 3), chiral chelating diphosphines, N-heterocyclic carbenes (NHCs), and phosphazene superbases (e.g., P 4- tBu). The P 4- tBu/Al(C 6F 5) 3 pair exhibits the highest activity of the LP series, with a remarkably high turn-over frequency of 9.6 × 10 4 h -1 (0.125 mol% catalyst, 100% MMA conversion in 30 s, M n = 2.12 × 10 5 g mol -1, PDI = 1.34). The polymers produced by LPs at RT are typically atactic (P γMMBL with ∼47% mr) or syndio-rich (PMMA with ∼70-75% rr), but highly syndiotactic PMMA with rr ∼91% can be produced by chiral or achiral LPs at -78 °C. Mechanistic studies have identified and structurally characterized zwitterionic phosphonium and imidazolium enolaluminates as the active species of the current LPP system, which are formed by the reaction of the monomer·Al(C 6F 5) 3 adduct with P tBu 3 and NHC bases, respectively. Kinetic studies have revealed that the MMA polymerization by the tBu 3P/ Al(C 6F 5) 3 pair is zero-order in monomer concentration after an initial induction period, and the polymerization

  1. Bringing the Future Within Reach: Celebrating 75 Years of the NASA John H. Glenn Research Center

    Science.gov (United States)

    Arrighi, Robert S.

    2016-01-01

    The National Aeronautics and Space Administration (NASA) Glenn Research Center in Cleveland, Ohio, has been making the future for 75 years. The center's work with aircraft engines, high-energy fuels, communications technology, electric propulsion, energy conversion and storage, and materials and structures has been, and continues to be, crucial to both the Agency and the region. Glenn has partnered with industry, universities, and other agencies to continually advance technologies that are propelling the nation's aerospace community into the future. Nonetheless these continued accomplishments would not be possible without the legacy of our first three decades of research, which led to over one hundred R&D 100 Awards, three Robert J. Collier Trophies, and an Emmy. Glenn, which is located in Cleveland, Ohio, is 1 of 10 NASA field centers, and 1 of only 3 that stem from an earlier research organization-the National Advisory Committee for Aeronautics (NACA). Glenn began operation in 1942 as the NACA Aircraft Engine Research Laboratory (AERL). In 1947 the NACA renamed the lab the Flight Propulsion Laboratory to reflect the expansion of the research. In September 1948, following the death of the NACA's Director of Aeronautics, George Lewis, the NACA rededicated the lab as the Lewis Flight Propulsion Laboratory. On 1 October 1958, the lab was incorporated into the new NASA space agency and was renamed the NASA Lewis Research Center. Following John Glenn's return to space on the space shuttle, on 1 March 1999 the center name was changed once again, becoming the NASA John H. Glenn Research Center.

  2. The NASA-Lewis program on fusion energy for space power and propulsion, 1958-1978

    Science.gov (United States)

    Schulze, Norman R.; Roth, J. Reece

    1990-01-01

    An historical synopsis is provided of the NASA-Lewis research program on fusion energy for space power and propulsion systems. It was initiated to explore the potential applications of fusion energy to space power and propulsion systems. Some fusion related accomplishments and program areas covered include: basic research on the Electric Field Bumpy Torus (EFBT) magnetoelectric fusion containment concept, including identification of its radial transport mechanism and confinement time scaling; operation of the Pilot Rig mirror machine, the first superconducting magnet facility to be used in plasma physics or fusion research; operation of the Superconducting Bumpy Torus magnet facility, first used to generate a toroidal magnetic field; steady state production of neutrons from DD reactions; studies of the direct conversion of plasma enthalpy to thrust by a direct fusion rocket via propellant addition and magnetic nozzles; power and propulsion system studies, including D(3)He power balance, neutron shielding, and refrigeration requirements; and development of large volume, high field superconducting and cryogenic magnet technology.

  3. A transition metal Lewis acid/base triad system for cooperative substrate binding.

    Science.gov (United States)

    Tutusaus, Oscar; Ni, Chengbao; Szymczak, Nathaniel K

    2013-03-06

    A frustrated Lewis pair accessory functionality is positioned in the secondary coordination sphere of a terpyridine ligand (Tpy(BN) = 6-morpholino-2,2':6',2″-terpyridine-6″-boronic acid pinacol ester) to promote directed Lewis acid/base interactions. Following metalation with VCl3, the utility of the metal Lewis acid/base triad (LABT) is highlighted with N2H4 as a cooperatively coordinated substrate, affording the first η(2)-[N2H3](-) vanadium complex.

  4. Diagnostic value of minor salivary glands biopsy for the detection of Lewy pathology.

    Science.gov (United States)

    Folgoas, Emmanuelle; Lebouvier, Thibaud; Leclair-Visonneau, Laurène; Cersosimo, Maria-Graciela; Barthelaix, Annick; Derkinderen, Pascal; Letournel, Franck

    2013-09-13

    The recent demonstration of the presence of Lewy pathology in the submandibular glands of Parkinson's disease (PD) patients prompted us to evaluate the diagnostic performance of minor salivary gland biopsy for PD. Minor salivary glands were examined for Lewy pathology using phosphorylated alpha-synuclein antibody in 16 patients with clinically diagnosed PD and 11 control subjects with other neurological disorders. Abnormal accumulation of alpha-synuclein was found in 3 out of 16 PD patients. Two control subjects exhibited weak phosphorylated alpha-synuclein immunoreactivity. Our results do not support the use of minor salivary glands biopsy for the detection of Lewy pathology in living subjects.

  5. Lewis and Clark National Historical Park Elk Monitoring Program Annual Report 2010

    Science.gov (United States)

    Cole, Carla; Griffin, Paul; Jenkins, Kurt

    2012-01-01

    Fiscal year 2010 was the second full year of elk monitoring protocol implementation at Lewis and Clark National Historical Park (LEWI), part of the North Coast and Cascades Network (NCCN) Inventory and Monitoring program. Elk monitoring at Lewis and Clark NHP includes two components. Fecal pellet surveys at a systematic sample of points in the Fort Clatsop unit are intended to give quantitative estimates of relative use by elk in that unit. Driving surveys on specified routes in and near the Fort Clatsop unit are intended to provide an index of elk viewing opportunities on those roads.

  6. Understanding the Role of Dispersion in Frustrated Lewis Pairs and Classical Lewis Adducts: A Domain-Based Local Pair Natural Orbital Coupled Cluster Study.

    Science.gov (United States)

    Bistoni, Giovanni; Auer, Alexander A; Neese, Frank

    2017-01-18

    The interaction of Lewis acids and bases in both classical Lewis adducts and frustrated Lewis pairs (FLPs) is investigated to elucidate the role that London dispersion plays in different situations. The analysis comprises 14 different adducts between tris(pentafluorophenyl)borane and a series of phosphines, carbenes, and amines with various substituents, differing in both steric and electronic properties. The domain-based local pair natural orbital coupled-cluster (DLPNO-CCSD(T)) method is used in conjunction with the recently introduced local energy decomposition (LED) analysis to obtain state-of-the-art dissociation energies and, at the same time, a clear-cut definition of the London dispersion component of the interaction, with the ultimate goal of aiding in the development of designing principles for acid/base pairs with well-defined bonding features and reactivity. In agreement with previous DFT investigations, it is found that the London dispersion dominates the interaction energy in FLPs, and is also remarkably strong in Lewis adducts. In these latter systems, its magnitude can be easily modulated by modifying the polarizability of the substituents on the basic center, which is consistent with the recently introduced concept of dispersion energy donors. By counteracting the destabilizing energy contribution associated with the deformation of the monomers, the London dispersion drives the stability of many Lewis adducts. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Research misconduct identified by the US Food and Drug Administration: out of sight, out of mind, out of the peer-reviewed literature.

    Science.gov (United States)

    Seife, Charles

    2015-04-01

    Every year, the US Food and Drug Administration (FDA) inspects several hundred clinical sites performing biomedical research on human participants and occasionally finds evidence of substantial departures from good clinical practice and research misconduct. However, the FDA has no systematic method of communicating these findings to the scientific community, leaving open the possibility that research misconduct detected by a government agency goes unremarked in the peer-reviewed literature. To identify published clinical trials in which an FDA inspection found significant evidence of objectionable conditions or practices, to describe violations, and to determine whether the violations are mentioned in the peer-reviewed literature. Cross-sectional analysis of publicly available documents, dated from January 1, 1998, to September 30, 2013, describing FDA inspections of clinical trial sites in which significant evidence of objectionable conditions or practices was found. For each inspection document that could be linked to a specific published clinical trial, the main measure was a yes/no determination of whether there was mention in the peer-reviewed literature of problems the FDA had identified. Fifty-seven published clinical trials were identified for which an FDA inspection of a trial site had found significant evidence of 1 or more of the following problems: falsification or submission of false information, 22 trials (39%); problems with adverse events reporting, 14 trials (25%); protocol violations, 42 trials (74%); inadequate or inaccurate recordkeeping, 35 trials (61%); failure to protect the safety of patients and/or issues with oversight or informed consent, 30 trials (53%); and violations not otherwise categorized, 20 trials (35%). Only 3 of the 78 publications (4%) that resulted from trials in which the FDA found significant violations mentioned the objectionable conditions or practices found during the inspection. No corrections, retractions, expressions

  8. Methodological approach and tools for systems thinking in health systems research: technical assistants' support of health administration reform in the Democratic Republic of Congo as an application.

    Science.gov (United States)

    Ribesse, Nathalie; Bossyns, Paul; Marchal, Bruno; Karemere, Hermes; Burman, Christopher J; Macq, Jean

    2017-03-01

    In the field of development cooperation, interest in systems thinking and complex systems theories as a methodological approach is increasingly recognised. And so it is in health systems research, which informs health development aid interventions. However, practical applications remain scarce to date. The objective of this article is to contribute to the body of knowledge by presenting the tools inspired by systems thinking and complexity theories and methodological lessons learned from their application. These tools were used in a case study. Detailed results of this study are in process for publication in additional articles. Applying a complexity 'lens', the subject of the case study is the role of long-term international technical assistance in supporting health administration reform at the provincial level in the Democratic Republic of Congo. The Methods section presents the guiding principles of systems thinking and complex systems, their relevance and implication for the subject under study, and the existing tools associated with those theories which inspired us in the design of the data collection and analysis process. The tools and their application processes are presented in the results section, and followed in the discussion section by the critical analysis of their innovative potential and emergent challenges. The overall methodology provides a coherent whole, each tool bringing a different and complementary perspective on the system.

  9. Education In Economics Versus Administrative Sciences. Research On The Gratuates’ Insertion In The Labor Market In The Context Of The New Economic Changes

    Directory of Open Access Journals (Sweden)

    Ioana Julieta Josan

    2015-01-01

    Full Text Available The purpose of the paper is to analyze the graduates’ insertion in the labor market in the context of the new economic changes and to reveal the relationship between education and their employability. This paper will focus attention on the role of formal higher education; particularly in Business and Administration graduates. The study will be based on a survey achieved through a qualitative research by the implementation of a questionnaire among a representative segment of graduates. It should be noted that this paper focuses on formal education as a mean of human capital accumulation. In the scientific literature there are studies recognized on both specialists and institutions level according to which education is the principal source of economic growth. The role of education consists in transmitting skills and aptitudes towards flexibility. This marks the entry in the new economy or knowledge society, in which competitiveness depends on skills and human capital possessed. Moreover, education is important not only for future productive capacity building but also for improving living standards. A better educated person will have more chances to get a better paying job and have more freedom to choose and decide what is best for his state of wealth. That person will also have the financial resources to take care of his health and access superior products and services.

  10. 公共行政学早期发展史上的研究与教育%Research and Education in the Early History of the Development of Public Administration

    Institute of Scientific and Technical Information of China (English)

    张康之; 张乾友

    2012-01-01

    Professional research and professional education in public administration emerged in the early 20th century, mainly linked to the rise of the municipal research movement. Municipal research movement achieved the focalization of research themes of public administration, not only accumulated a great deal of valuable raw materials, but also further highlighted the scientific orientation of methodology in public administration. It was because of the municipal research movement, which actualized the focalization of themes in public administration, and define the scientific orientation of public administration, that Ameri can scholars gradually acquired the right to speak in public administration, and assumed the leadership of the public admin istration discipline const~'uction task. After years of research and teaching, the municipal research movement summed up the practical elements and disciplinary constitutes of public administration, roughly delineated the areas of public administration, and laid a solid foundation for the prosperity of Public Administration in the 20th century.%公共行政专业研究和专业教育兴起于20世纪初期,主要是与美国市政研究运动的兴起联系在一起的。市政研究运动实现了公共行政研究主题的聚焦,不仅积累了大量宝贵的原始资料,而且在方法论上也使公共行政的科学化取向得以进一步凸现。正是由于市政研究运动,实现了公共行政的主题聚焦,并明确了公共行政的科学取向,从而使美国学者逐渐掌握了公共行政研究的话语权,承担起了领导公共行政学学科建构的任务。经过多年的研究与教学,市政研究运动总结出了公共行政的实践要素与学科构成,大致划定了公共行政的领域。为公共行政学在20世纪走向繁荣奠定了坚实的基础。

  11. Urban School Administration.

    Science.gov (United States)

    McKelvey, Troy V., Ed.; Swanson, Austin D., Ed.

    This document contains 12 papers presented at an institute for urban school administrators designed to deal with the contemporary urban educational problems incident to school desegregation, social integration, and the equality of educational opportunity. The authors of the papers relate recent research findings to practical field experience, and…

  12. ADMINISTRATIVE RULEMAKING IN ETHIOPIA:

    African Journals Online (AJOL)

    MLR

    or policy or describing the organization, procedure, or practice requirements of an agency … ... Draft Proclamation) prepared by the Justice and Legal System Research ... organ of the government as in the cases of contract law, criminal law, family ..... public is an important administrative procedure they all share in common.

  13. Administrative contracts

    Directory of Open Access Journals (Sweden)

    Vukićević-Petković Milica

    2015-01-01

    Full Text Available Administrative contracts are a special type of contract where usually one of the contracting parties is a public law body and which is concluded for the performance of public service and the realization of a public interest. They go a long way since its inception to its eventual final acceptance of all the legal systems. One of the enduring characteristics of this type of contract is their disquised or unnoticed existence. This is why only monitoring their development may lead to a complete understanding of the importance and essence of this institution as well as the need for its complete legal regulation.

  14. Heat transfer and pressure drop performance of a finned-tube heat exchanger proposed for use in the NASA Lewis Altitude Wind Tunnel

    Science.gov (United States)

    Vanfossen, G. J.

    1985-01-01

    A segment of the heat exchanger proposed for use in the NASA Lewis Altitude Wind Tunnel (AWT) facility has been tested under dry and icing conditions. The heat exchanger has the largest pressure drop of any component in the AWT loop. It is therefore critical that its performance be known at all conditions before the final design of the AWT is complete. The heat exchanger segment is tested in the NASA Lewis Icing Research Tunnel (IRT) in order to provide an icing cloud environment similar to what will be encountered in the AWT. Dry heat transfer and pressure drop data are obtained and compared to correlations available in the literature. The effects of icing sprays on heat transfer and pressure drop are also investigated.

  15. Cassini Radio Science Experiments on Saturn and Titan Preserved Because of Lewis Analysis

    Science.gov (United States)

    Wilson, Jeffrey D.

    1999-01-01

    The Cassini mission to Saturn is an international venture with participation from NASA, the European Space Agency, and the Italian Space Agency. The Cassini spacecraft was launched from Cape Canaveral in October 1997 and is scheduled to arrive at Saturn in July 2004. After arrival, the spacecraft will orbit Saturn about 60 times over a period of 4 years. During this time, the Cassini Radio Science Subsystem will be used to investigate the atmosphere and rings of Saturn and the atmosphere of its largest moon, Titan--which is larger than Mercury and is the only moon in our solar system with a dense atmosphere. A critical component in Cassini s Radio Science Subsystem is a traveling-wave tube (TWT) that was designed at the NASA Lewis Research Center and built by Hughes Electronic Dynamics Division (ref. 1). This TWT will amplify downlink microwave signals at a frequency of 32 GHz for the Deep Space Network and will be involved in a number of experiments. These include occultation experiments in which the microwave signal will be beamed through rings and atmospheres toward Earth. Researchers will analyze the received signals to determine the sizes and distributions of the particles in the rings and the structure and composition of the atmospheres. The Radio Science Subsystem also will also be used to more accurately determine the mass and size of Saturn and its moons, to investigate the solar corona, and to search for gravity waves from outside the solar system.

  16. Cassini Radio Science Experiments on Saturn and Titan Preserved Because of Lewis Analysis

    Science.gov (United States)

    Wilson, Jeffrey D.

    1999-01-01

    The Cassini mission to Saturn is an international venture with participation from NASA, the European Space Agency, and the Italian Space Agency. The Cassini spacecraft was launched from Cape Canaveral in October 1997 and is scheduled to arrive at Saturn in July 2004. After arrival, the spacecraft will orbit Saturn about 60 times over a period of 4 years. During this time, the Cassini Radio Science Subsystem will be used to investigate the atmosphere and rings of Saturn and the atmosphere of its largest moon, Titan--which is larger than Mercury and is the only moon in our solar system with a dense atmosphere. A critical component in Cassini s Radio Science Subsystem is a traveling-wave tube (TWT) that was designed at the NASA Lewis Research Center and built by Hughes Electronic Dynamics Division (ref. 1). This TWT will amplify downlink microwave signals at a frequency of 32 GHz for the Deep Space Network and will be involved in a number of experiments. These include occultation experiments in which the microwave signal will be beamed through rings and atmospheres toward Earth. Researchers will analyze the received signals to determine the sizes and distributions of the particles in the rings and the structure and composition of the atmospheres. The Radio Science Subsystem also will also be used to more accurately determine the mass and size of Saturn and its moons, to investigate the solar corona, and to search for gravity waves from outside the solar system.

  17. Overview of the NASA Lewis component technology program for Stirling power converters

    Science.gov (United States)

    Thieme, Lanny G.; Swec, Diane M.

    1992-01-01

    This paper presents an update on the NASA Lewis Stirling component technology program. The component technology program has been organized as part of the NASA Lewis effort to develop Stirling converter technology for space power applications. The Stirling space power program is part of the High Capacity Power element of the NASA Civil Space Technology Initiative. Lewis is also providing technical management of a DOE-funded project to develop Stirling converter systems for distributed dish solar terrestrial power applications. The Lewis component technology program is coordinated with the primary contract efforts of these projects but is aimed at longer term issues, advanced technologies, and independent assessments. Topics to be discussed include bearings, linear alternators, controls and load interaction, materials/life assessment, and heat exchangers.

  18. Summary of the NASA Lewis component technology program for Stirling power converters

    Science.gov (United States)

    Thieme, Lanny G.; Swec, Diane M.

    1992-01-01

    An update is presented on the NASA Lewis Stirling component technology program. The component technology program has been organized as part of the NASA Lewis effort to develop Stirling converter technology for space power applications. The Stirling space power project is part of the High Capacity Power element of the NASA Civil Space Technology Initiative (CSTI). Lewis is also providing technical management of a DOE funded project to develop Stirling converter systems for distributed dish solar terrestrial power applications. The primary contractors for the space power and solar terrestrial projects develop component technologies directly related to their project goals. This Lewis component technology program, while coordinated with these main projects, is aimed at longer term issues, advanced technologies, and independent assessments. Topics to be discussed include bearings, linear alternators, controls and load interaction, materials/life assessment, and heat exchangers.

  19. Highlighting High Performance: Adam Joseph Lewis Center for Environmental Studies, Oberlin College, Oberlin, Ohio

    Energy Technology Data Exchange (ETDEWEB)

    None

    2002-11-01

    Oberlin College’s Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials

  20. Synergistic effects between Lewis and Brønsted acids: application to the Prins cyclization.

    Science.gov (United States)

    Breugst, Martin; Grée, René; Houk, K N

    2013-10-04

    Brønsted and Lewis acids can catalyze the Prins cyclization, an efficient method for the synthesis of tetrahydropyrans from homoallylic alcohols and carbonyl compounds. Synergistic effects between weak Brønsted and Lewis acids in these reactions have been analyzed by density functional theory [M06-L/def2-QZVP/IEFPCM(CH2Cl2)//M06-L/6-311+G(2df,2p)]. In order to characterize the reactivities of the employed Lewis acids, methyl anion and hydroxide affinities were determined. On the basis of our calculations, we found that the coordination of Lewis acids to carboxylic and sulfonic acids results in a significant increase in the Brønsted acidities of the latter.

  1. Lewis Acid Catalyzed Selective Reactions of Donor-Acceptor Cyclopropanes with 2-Naphthols.

    Science.gov (United States)

    Kaicharla, Trinadh; Roy, Tony; Thangaraj, Manikandan; Gonnade, Rajesh G; Biju, Akkattu T

    2016-08-16

    Lewis acid-catalyzed reactions of 2-substituted cyclopropane 1,1-dicarboxylates with 2-naphthols is reported. The reaction exhibits tunable selectivity depending on the nature of Lewis acid employed and proceed as a dearomatization/rearomatization sequence. With Bi(OTf)3 as the Lewis acid, a highly selective dehydrative [3+2] cyclopentannulation takes place leading to the formation of naphthalene-fused cyclopentanes. Interestingly, engaging Sc(OTf)3 as the Lewis acid, a Friedel-Crafts-type addition of 2-naphthols to cyclopropanes takes place, thus affording functionalized 2-naphthols. Both reactions furnished the target products in high regioselectivity and moderate to high yields. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Barack Obama, John Lewis, and the Legacy of the Civil Rights Struggle

    Directory of Open Access Journals (Sweden)

    Glenn T. Eskew

    2012-01-01

    Full Text Available The watershed election in 2008 of Barack Obama as the first President of the United States to have African ancestry resulted from the life work of such civil rights activists as U.S. Congressman John Lewis. Born on a sharecropper’s farm in 1940, the African American Lewis grew up in segregated Alabama. As a college student in Nashville, he joined the sit-in protests and volunteered for the original Freedom Ride in 1961. He was elected chairman of the Student Nonviolent Coordinating Committee, becoming the youngest speaker at the March on Washington in 1963. The radical shift to Black ultimately forced Lewis out of SNCC. Consequently Lewis capitalized on the Voting Rights Act of 1965, turned his attentions to voter registration campaigns, and continued working within the system. In 1986 he won election to the U.S. House of Representatives to represent Atlanta’s Fifth Congressional District, a seat he continues to hold today.

  3. Different Characters of Spleen OX-62 Positive Dendritic Cells between Fischer and Lewis Rats

    Institute of Scientific and Technical Information of China (English)

    Linsong Yang; Yayi Hou

    2006-01-01

    The phenotype, DNA-binding activities of NF-κB, cytokine production, endocytosis and stimulatory capacity of spleen OX-62-positive dendritc cells (SDCs) from Fischer rats were compared with those from Lewis rats. Results showed that the expressions of CD11b, MHC-Ⅱ, CD8, CD45RA, CD54 and CD86 on SDCs were significantly higher in Fischer than those in Lewis rats. The levels of IL-2, IL-4, IL-10 and IFN-γ in SDCs from Fischer rats were distinctly higher than those from Lewis. Both stimulatory capacity and DNA-binding activities of NF-κB in SDCs were all lower in Fischer than those in Lewis rats. These differences may partly contribute to rat strainspecificity in susceptibility to chronic inflammatory stimuli.

  4. Organo-Lewis acid as cocatalyst for cationic homogenous metallocene Ziegler-Natta olefin polymerizations

    Science.gov (United States)

    Marks, Tobin J.; Chen, You-Xian

    2000-01-01

    The synthesis of the organo-Lewis acid perfluorobiphenylborane (PBB) and the activation of metallocenes for the formation of a variety of highly active homogeneous Ziegler-Natta metallocene olefin polymerization, copolymerization and ring-opening polymerization catalysts is described.

  5. Effects of fucosylated milk of goat and mouse on Helicobacter pylori binding to Lewis b antigen

    Institute of Scientific and Technical Information of China (English)

    Hong-Tao Xu; Ning Li; Lennart Hammarstr(o)m; Thomas Borén; Rolf Sj(o)str(o)m; Yao-Feng Zhao; Zheng-Xing Lian; Bao-Liang Fan; Zhi-Hui Zhao; Shu-Yang Yu; Yun-Ping Dai; Li-Li Wang; Hui-Ling Niu

    2004-01-01

    AIM: To evaluate the effects of animal milk containing fucosylated antigens on Helicobacter pylori (Hpylori) binding to Lewis b antigen.METHODS: A mammary gland expression vector containing human α1-3/4-fucosyltransferase cDNA sequences was constructed. Transient expression of human α1-3/4-fucosyltransferase cDNA in goat mammary cell and establishment of transgenic mice were performed. The adhesion inhibitory properties of milk samples were analyzed by using H pylori RESULTS: Goat milk samples were found to inhibit bacterial binding to Lewis b antigen. The highest inhibition was observed 42 h after injection of the plasmid. The binding activity of Hpylori to Lewis b antigen reduced mostly, by 83%, however milk samples from transgenic mice did not inhibit H pylori binding to Lewis b antigen.CONCLUSION: The use of "humanized" animal milk produced by the transgenic introduction of fucosylated antigen can perhaps provide an alternative therapy and preventive measure for H pylori infection.

  6. CD3 in Lewy Pathology: Does the Abnormal Recall of Neurodevelopmental Processes Underlie Parkinson's Disease

    Science.gov (United States)

    Castellani, Rudy J.; Nugent, Summer L.; Morrison, Alan L.; Zhu, Xiongwei; Lee, Hyoung-gon; Harris, Peggy L. R.; Bajić, Vladan; Sharma, Hari S.; Chen, Shu G.; Oettgen, Peter; Perry, George; Smith, Mark A.

    2011-01-01

    CD3ζ is a subunit of the CD3 molecule that, until recently, appeared restricted to T-cells and natural killer cells. However, experimental studies have demonstrated a role of CD3ζ in dendritic outgrowth in the visual system as well as in synaptic plasticity. Given the increasing evidence for uncharacteristic recapitulation of neurodevelopmental processes in neurodegenerative diseases, in this study, we evaluated brains from subjects with Parkinson's disease and Lewy body dementia for evidence of aberrant CD3 expression. Our data shows marked CD3ζ in association with the α-synuclein containing pathological lesions, i.e., Lewy bodies and Lewy neurites, in the brains of subjects with Parkinson's disease and Lewy body dementia. This finding raises the novel concept of CD3 dysregulation in these disorders as a pathogenic factor and also furthers the increasing evidence that the recall of aberrant neurodevelopmental processes underlies the pathogenesis of neurodegenerative diseases. PMID:20972807

  7. [Book review] The youngest science: notes of a medicine-watcher, by Lewis Thomas

    Science.gov (United States)

    Johnson, D.H.

    1984-01-01

    Review of: The youngest science: notes of a medicine-watcher. Alfred P. Sloan Foundation Series. Lewis Thomas. Penguin Books, 1995. Pennsylvania State University. 270 pp. ISBN: 0140243275, 9780140243277.

  8. Overview of the NASA Lewis component technology program for Stirling power converters

    Science.gov (United States)

    Thieme, Lanny G.; Swec, Diane M.

    This paper presents an update on the NASA Lewis Stirling component technology program. The component technology program has been organized as part of the NASA Lewis effort to develop Stirling converter technology for space power applications. The Stirling space power program is part of the High Capacity Power element of the NASA Civil Space Technology Initiative. Lewis is also providing technical management of a DOE-funded project to develop Stirling converter systems for distributed dish solar terrestrial power applications. The Lewis component technology program is coordinated with the primary contract efforts of these projects but is aimed at longer term issues, advanced technologies, and independent assessments. Topics to be discussed include bearings, linear alternators, controls and load interaction, materials/life assessment, and heat exchangers.

  9. Summary of the NASA Lewis component technology program for Stirling power converters

    Science.gov (United States)

    Thieme, Lanny G.; Swec, Diane M.

    1992-10-01

    An update is presented on the NASA Lewis Stirling component technology program. The component technology program has been organized as part of the NASA Lewis effort to develop Stirling converter technology for space power applications. The Stirling space power project is part of the High Capacity Power element of the NASA Civil Space Technology Initiative (CSTI). Lewis is also providing technical management of a DOE funded project to develop Stirling converter systems for distributed dish solar terrestrial power applications. The primary contractors for the space power and solar terrestrial projects develop component technologies directly related to their project goals. This Lewis component technology program, while coordinated with these main projects, is aimed at longer term issues, advanced technologies, and independent assessments. Topics to be discussed include bearings, linear alternators, controls and load interaction, materials/life assessment, and heat exchangers.

  10. Assembly of a Library of Trisaccharides as Mimics of Sialyl Lewis X via Random Combination Strategy

    Institute of Scientific and Technical Information of China (English)

    Xiang Bao MENG; Hui LI; Qing LI; Tie Ming CHENG; Zhong Jun LI

    2004-01-01

    A small library containing six positional isomers of fucosyl on the modified lactoside backbone as mimics of the Sialyl Lewis X was synthesized via random combinatorial glycosylation,which was charactered by ESI-MS and HPLC.

  11. Junior and Community College Research, Texas, 1977-78. The Seventh Annual Report to the Texas Association of Junior and Community College Instructional Administrators.

    Science.gov (United States)

    Byrd, R. Eugene, Ed.

    The first of three studies presented in this report investigated the role of the academic dean/dean of instruction as related to the effectiveness of educational leadership in junior colleges. Using the Educational Administrative Style Diagnosis Test and the Educational Administrative Appropriateness Test, 60 deans, representing 47 Texas community…

  12. Thioarsenides: A case for long-range Lewis acid-base-directed van der Waals interactions

    Energy Technology Data Exchange (ETDEWEB)

    Gibbs, Gerald V.; Wallace, Adam F.; Downs, R. T.; Ross, Nancy L.; Cox, David F.; Rosso, Kevin M.

    2011-04-01

    Electron density distributions, bond paths, Laplacian and local energy density properties have been calculated for a number of As4Sn (n = 3,4,5) thioarsenide molecular crystals. On the basis of the distributions, the intramolecular As-S and As-As interactions classify as shared bonded interactions and the intermolecular As-S, As-As and S-S interactions classify as closed-shell van der Waals bonded interactions. The bulk of the intermolecular As-S bond paths link regions of locally concentrated electron density (Lewis base regions) with aligned regions of locally depleted electron density (Lewis acid regions) on adjacent molecules. The paths are comparable with intermolecular paths reported for several other molecular crystals that link aligned Lewis base and acid regions in a key-lock fashion, interactions that classified as long range Lewis acid-base directed van der Waals interactions. As the bulk of the intermolecular As-S bond paths (~70%) link Lewis acid-base regions on adjacent molecules, it appears that molecules adopt an arrangement that maximizes the number of As-S Lewis acid-base intermolecular bonded interactions. The maximization of the number of Lewis acid-base interactions appears to be connected with the close-packed array adopted by molecules: distorted cubic close-packed arrays are adopted for alacránite, pararealgar, uzonite, realgar and β-AsS and the distorted hexagonal close-packed arrays adopted by α- and β-dimorphite. A growth mechanism is proposed for thioarsenide molecular crystals from aqueous species that maximizes the number of long range Lewis acid-base vdW As-S bonded interactions with the resulting directed bond paths structuralizing the molecules as a molecular crystal.

  13. Visual Hallucinations in PD and Lewy Body Dementias: Old and New Hypotheses

    Directory of Open Access Journals (Sweden)

    M. Onofrj

    2013-01-01

    Full Text Available Visual Hallucinations (VH are a common non-motor symptom of Parkinson’s Disease (PD and the Lewy body dementias (LBD of Parkinson's disease with dementia (PDD and Dementia with Lewy Bodies (DLB. The origin of VH in PD and LBD is debated: earlier studies considered a number of different possible mechanisms underlying VH including visual disorders, Rapid Eye Movement (REM Sleep Intrusions, dysfunctions of top down or bottom up visual pathways, and neurotransmitter imbalance.

  14. The Glycolysis of Poly(ethylene terephthalate) Waste: Lewis Acidic Ionic Liquids as High Efficient Catalysts

    OpenAIRE

    Mi Lin Zhang; Xue Feng Bai; Qun Feng Yue; Lin Fei Xiao

    2013-01-01

    Poly(ethlyene terephthalate) waste from a local market was depolymerized by ethylene glycol (EG) in the presence of Lewis acidic ionic liquids [Bmim]ZnCl3 and the qualitative analysis showed that bis(hydroxyethyl) terephthalate was the main product. Compared with ionic liquid [Bmim]Cl, the Lewis acidic ionic liquids showed highly catalytic activity in the glycolysis of poly(ethylene terephthalate) PET. Significantly, the conversion of PET and the yield of bis(hydroxyethyl) terephthalate were ...

  15. Prospective study of relations between cortical Lewy bodies, poor eyesight, and hallucinations in Alzheimer's disease.

    OpenAIRE

    McShane, R.; Gedling, K; Reading, M.; McDonald, B.; Esiri, M M; Hope, T

    1995-01-01

    The presence of hallucinations is included in some, but not all, of the sets of clinical diagnostic criteria that have been proposed for dementia associated with cortical Lewy bodies. These criteria were developed from retrospective casenote analyses. This prospective, longitudinal study suggests that, in patients with Alzheimer's disease, cortical Lewy bodies are associated with more persistent and severe hallucinations, independently of any association with severity of cognitive decline. Po...

  16. Prospective study of relations between cortical Lewy bodies, poor eyesight, and hallucinations in Alzheimer's disease.

    Science.gov (United States)

    McShane, R; Gedling, K; Reading, M; McDonald, B; Esiri, M M; Hope, T

    1995-08-01

    The presence of hallucinations is included in some, but not all, of the sets of clinical diagnostic criteria that have been proposed for dementia associated with cortical Lewy bodies. These criteria were developed from retrospective casenote analyses. This prospective, longitudinal study suggests that, in patients with Alzheimer's disease, cortical Lewy bodies are associated with more persistent and severe hallucinations, independently of any association with severity of cognitive decline. Poor eyesight contributes to the severity but not the persistence of the hallucinations.

  17. ADMINISTRATIVE CIRCULARS

    CERN Multimedia

    Division des ressources humaines

    2000-01-01

    N° 2 (Rev. 1) - March 2000Guidelines and procedures concerning recruitment and probation period of staff membersN° 9 (Rev. 2) - March 2000Staff members contractsN° 16 (Rev. 2) - January 2000TrainingN° 30 (Rev. 1) - January 2000Indemnities and reimbursements upon taking up appointment and termination of contractN° 32 - February 2000Principles and procedures governing complaints of harassmentThese circular have been amended (No 2, N° 9, N° 16 and N° 30) or drawn up (N° 32).Copies are available in the Divisional Secretariats.Note:\tAdministrative and operational circulars, as well as the lists of those in force, are available for consultation in the server SRV4_Home in the Appletalk zone NOVELL (as GUEST or using your Novell username and password), volume PE Division Data Disk.The Word files are available in the folder COM, folder Public, folder ADM.CIRC.docHuman Resources DivisionTel. 74128

  18. Fate of TCE in heated Fort Lewis soil.

    Science.gov (United States)

    Costanza, Jed; Fletcher, Kelly E; Löffler, Frank E; Pennell, Kurt D

    2009-02-01

    This study explores the transformation of trichloroethene (TCE) caused by heating contaminated soil and groundwater samples obtained from the East Gate Disposal Yard (EGDY) located in Fort Lewis, WA. After field samples transferring into glass ampules and introducing 1.5 micromol of TCE, the sealed ampules were incubated at temperatures of 25, 50, and 95 degrees C for periods of up to 95.5 days. Although TCE was completely transformed into cis-1,2-dichloroethene (cis-DCE) after 42 days at 25 degrees C by microbial activity, this transformation was not observed at 50 or 95 degrees C. Chloride levels increased after 42 days at 25 degrees C corresponding to the mass of TCE transformed to cis-DCE, were constant at 50 degrees C, and increased at 95 degrees C yielding a TCE degradation half-life of 1.6-1.9 years. These findings indicate that indigenous microbes contribute to the partial dechlorination of TCE to cis-DCE at temperatures of less than 50 degrees C, whereas interphase mass transfer and physical recovery of TCE will predominate over in situ degradation processes at temperatures of greater than 50 degrees C during thermal treatment at the EGDY site.

  19. Lewis-Sumner syndrome and multifocal motor neuropathy.

    Science.gov (United States)

    Verschueren, Annie; Azulay, Jean Philippe; Attarian, Shahram; Boucraut, José; Pellissier, Jean François; Pouget, Jean

    2005-01-01

    We compared the clinical, electrophysiological, laboratory, and pathological features of 13 patients with Lewis-Sumner syndrome (LSS) with those of 20 patients with multifocal motor neuropathy (MMN). LSS and MMN patients have several common clinical features: age at onset, weakness in the distribution of individual peripheral nerves, mild wasting, cramps and fasciculations, partial areflexia, and frequent stepwise disease course. Cerebrospinal fluid protein level was normal or slightly elevated, but always less than 100 mg/dl. Conduction blocks are the electrophysiological hallmarks of these two neuropathies, and no differences in distribution and number of blocks were found. Contrary to MMN, lower-limb involvement at onset was frequent in LSS but extension to the upper limbs was a frequent later feature of the disease. Cranial nerve involvement was noted in 4 LSS patients during relapses and absent in all MMN patients. The major distinguishing features were the clinical and electrophysiological sensory involvement in LSS, and the lack of anti-GM1 antibodies in LSS, whereas IgM anti-GM1 were found in 40% of MMN patients. Some LSS patients responded to steroid therapy, whereas this was ineffective in MMN. From these features, LSS can be considered an entity distinct from MMN, with its own clinical, laboratory, and electrophysiological characteristics, and as an intermediate link between chronic inflammatory demyelinating polyneuropathy and MMN.

  20. Lewis Swift celebrated comet hunter and the people's astronomer

    CERN Document Server

    Kronk, Gary W

    2017-01-01

    This biography covers the life of Lewis Swift (1820-1913), who discovered 13 comets and nearly 1,200 other deep sky objects. All 13 comets found by Swift now bear his name, including three periodic comets with periods of 6 years (11P/Tempel-Swift-LINEAR), 9 years (64P/Swift-Gehrels), and 133 years (109P/Swift-Tuttle). Swift's enthusiasm and success as an amateur astronomer helped make him famous in the United States. With the help of others, Swift was able to buy a 16-inch refractor, the third largest telescope in the United States at the time. Hulbert Harrington Warner built "Warner Observatory" to house this telescope. As a prolific writer and lecturer, Swift's stories appeared in newspapers and magazines, while his lectures showed that he was able to explain anything in a way that everyone could understand.  When Warner went broke during the "Panic of 1893," Swift was forced to leave his home. Almost two dozen invitations arrived from around the United States asking him to bring his telescope to their ci...

  1. Cyclosporin a. Inhibition of experimental autoimmune uveitis in Lewis rats.

    Science.gov (United States)

    Nussenblatt, R B; Rodrigues, M M; Wacker, W B; Cevario, S J; Salinas-Carmona, M C; Gery, I

    1981-01-01

    Cyclosporin A (CS-A), a selective inhibitor of T lymphocytes, is reported here to prevent S antigen (S-Ag) induced uveitis in Lewis rats. The S-Ag, found in all mammalian retinas, is uveitogenic under experimental conditions and patients with certain uveitic entities demonstrate cell mediated responses to this antigen. Daily treatment with CS-A (10 mg/kg) begun on the same day as S-Ag immunization totally inhibited the development of the uveitis in this experimental autoimmune model. Moreover a greater CS-A dose (40 mg/kg) efficiently prevented the disease process when therapy was started 7 d after S-Ag immunization. Anti-S-Ag antibody titers were observed to be similar in rats either protected or not protected with CS-A. Our data support strongly the need for T cell participation in this disease model. Since ocular inflammatory disease is an important cause of visual impairment, the data further suggest that CS-A may be useful in the treatment of patients with intractable uveitis. Images PMID:7204576

  2. Functional evaluation of cerebral cortex in dementia with Lewy bodies.

    Science.gov (United States)

    Di Lazzaro, Vincenzo; Pilato, Fabio; Dileone, Michele; Saturno, Eleonora; Profice, Paolo; Marra, Camillo; Daniele, Antonio; Ranieri, Federico; Quaranta, Davide; Gainotti, Guido; Tonali, Pietro A

    2007-08-15

    Neurochemical investigations have demonstrated central cholinergic dysfunction in patients with dementia with Lewy bodies (DLB). Central cholinergic circuits of the human brain can be tested non-invasively by coupling peripheral nerve stimulation with transcranial magnetic stimulation of the contralateral motor cortex. This test, named short latency afferent inhibition has been shown in healthy subjects to be sensitive to the blockage of muscarinic acetylcholine receptors and it is impaired in patients with Alzheimer disease (AD), a cholinergic form of dementia, while it is normal in non-cholinergic forms of dementia such as fronto-temporal dementia. We evaluated short latency afferent inhibition in a group of patients with DLB and compared the data with that from a group of AD patients and a control group of age-matched healthy individuals. Short latency afferent inhibition was significantly reduced in DLB and AD patients. The findings suggest that this method can be used as a non-invasive test for the assessment of cholinergic pathways in patients with dementia and may represent a useful additional tool for discriminating between cholinergic and non-cholinergic forms of dementia.

  3. Liquid-Phase Catalytic Transfer Hydrogenation of Furfural over Homogeneous Lewis Acid-Ru/C Catalysts.

    Science.gov (United States)

    Panagiotopoulou, Paraskevi; Martin, Nickolas; Vlachos, Dionisios G

    2015-06-22

    The catalytic performance of homogeneous Lewis acid catalysts and their interaction with Ru/C catalyst are studied in the catalytic transfer hydrogenation of furfural by using 2-propanol as a solvent and hydrogen donor. We find that Lewis acid catalysts hydrogenate the furfural to furfuryl alcohol, which is then etherified with 2-propanol. The catalytic activity is correlated with an empirical scale of Lewis acid strength and exhibits a volcano behavior. Lanthanides are the most active, with DyCl3 giving complete furfural conversion and a 97 % yield of furfuryl alcohol at 180 °C after 3 h. The combination of Lewis acid and Ru/C catalysts results in synergy for the stronger Lewis acid catalysts, with a significant increase in the furfural conversion and methyl furan yield. Optimum results are obtained by using Ru/C combined with VCl3 , AlCl3 , SnCl4 , YbCl3 , and RuCl3 . Our results indicate that the combination of Lewis acid/metal catalysts is a general strategy for performing tandem reactions in the upgrade of furans.

  4. Potential of the aminosterol, squalamine in combination therapy in the rat 13,762 mammary carcinoma and the murine Lewis lung carcinoma.

    Science.gov (United States)

    Teicher, B A; Williams, J I; Takeuchi, H; Ara, G; Herbst, R S; Buxton, D

    1998-01-01

    Squalamine, a naturally-occurring aminosterol, has demonstrated antiangiogenic activity in several experimental models. Extended treatment with other antiangiogenic agents has been shown to increase tumor oxygenation. Tumor oxygenation was measured using an Eppendorf pO2 histograph polarographic pO2 electrode system in the rat 13,762 mammary carcinoma after treatment of the tumor-bearing animals with squalamine (40 mglkg) on days 4 through 18 post tumor implantation. Under air breathing conditions, the hypoxic fraction (percent of pO2 readings squalamine treated animals. While squalamine administration alone produced only a modest effect on the growth of the 13,762 tumor, there were increases in tumor growth delay of 1.9- to 2.5-fold when squalamine was administered along with cyclophosphamide, cisplatin and paclitaxel compared with the tumor growth delays observed with the chemotherapeutic agents alone. To determine the efficacy of squalamine alone and along with cytotoxic therapies against a model of primary and systemic disease, squalamine was administered to animals bearing the Lewis lung carcinoma by daily subcutaneous injection or by continuous infusion on days 4 through 18 post tumor implantation. Squalamine as a single agent had only a modest effect on the growth of the primary Lewis lung tumor but increased the tumor growth delays produced by cyclophosphamide, cisplatin, paclitaxel and 5-fluorouracil by 2.4- to 3.8-fold compared with the anticancer drugs alone. Squalamine administration alone substantially decreased the number of lung metastases found in animals bearing the Lewis lung carcinoma and further decreased the number of lung metastases when administered along with the chemotherapeutic agents.

  5. Virtual Reality and Public Administration

    OpenAIRE

    Tózsa, István

    2013-01-01

    This study serves as an introduction to how virtual reality systems could be applied in public administration and what research tasks would be necessary to accomplish a project. E-government solutions began to emerge in public administration approximately a decade ago all over the developed world. Administration service facilities via the Internet did not attract many customers, because of the digital divide. E-government solutions were extended to mobile devices as well, but the expected bre...

  6. Helicobacter pylori Does Not Require Lewis X or Lewis Y Expression To Colonize C3H/HeJ mice

    Science.gov (United States)

    Takata, Tohru; El-Omar, Emad; Camorlinga, Margarita; Thompson, Stuart A.; Minohara, Yutaka; Ernst, Peter B.; Blaser, Martin J.

    2002-01-01

    Helicobacter pylori strains frequently express Lewis X (Lex) and/or Ley on their cell surfaces as constituents of the O antigens of their lipopolysaccharide molecules. To assess the effect of Lex and Ley expression on the ability of H. pylori to colonize the mouse stomach and to adhere to epithelial cells, isogenic mutants were created in which fucT1 alone or fucT1 and fucT2, which encode the fucosyl transferases necessary for Lex and Ley expression, were deleted. C3H/HeJ mice were experimentally challenged with either wild-type 26695 H. pylori or its isogenic mutants. All strains, whether passaged in the laboratory or recovered after mouse passage, colonized the mice well and without consistent differences. During colonization by the mutants, there was no reversion to wild type. Similarly, adherence to AGS and KatoIII cells was unaffected by the mutations. Together, these findings indicate that Le expression is not necessary for mouse gastric colonization or for H. pylori adherence to epithelial cells. PMID:12011000

  7. Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies☆

    Science.gov (United States)

    Bonanni, Laura; Perfetti, Bernardo; Bifolchetti, Stefania; Taylor, John-Paul; Franciotti, Raffaella; Parnetti, Lucilla; Thomas, Astrid; Onofrj, Marco

    2015-01-01

    Mild cognitive impairment (MCI) as a precursor of dementia with Lewy bodies (DLB) is the focus of recent research, trying to explore the early mechanisms and possible biomarkers of DLB. Quantitative electroencephalogram (QEEG) methods are able to differentiate early DLB from Alzheimer's disease (AD). The aim of the present study was to assess whether QEEG abnormalities, characterized by dominant frequency 1.5 Hz, typical of early DLB, are already present at the stage of MCI and to evaluate whether EEG abnormalities can predict the development of DLB. Forty-seven MCI subjects were followed for 3 years. EEG recordings were obtained at admission and at the end of the study. At the end of follow-up, 20 subjects had developed probable DLB (MCI-DLB), 14 had probable AD (MCI-AD), 8 did not convert to dementia, 5 developed a non-AD/DLB dementia. One hundred percent of MCI-DLB showed EEG abnormalities at admission. Ninety three percent of MCI-AD maintained a normal EEG throughout the study. QEEG may represent a powerful tool to predict the progression from MCI to DLB with a sensitivity and specificity close to 100%. PMID:25129239

  8. Operation of the 25 kW NASA Lewis Solar Regenerative Fuel Cell Testbed Facility

    Energy Technology Data Exchange (ETDEWEB)

    Voecks, G.E.; Rohatgi, N.K.; Moore, S.H. [Jet Propulsion Lab., Pasadena, CA (United States)] [and others

    1996-12-31

    Assembly of the NASA Lewis Research Center Solar Regenerative Fuel Cell Testbed Facility has recently been completed and system testing is in progress. This facility includes the integration of 50 kW photovoltaic solar cell arrays, a 25 kW proton exchange membrane (PEM) electrolysis unit, four 5 kW PEM fuel cells, high pressure hydrogen and oxygen storage vessels, high purity water storage containers, and computer monitoring, control and data acquisition. The purpose of this facility is multi-faceted, but was originally intended to serve as a testbed for evaluating a closed-loop powerplant for future NASA extended life support operations, such as a Lunar outpost, and also as a terrestrial powerplant example for remote or continuous back-up support operations. The fuel cell and electrolyzer subsystems design and assembly were conducted by the Jet Propulsion Laboratory (JPL), the photovoltaic arrays and electrical interconnect to the electrolyzer were provided by the US Navy/China Lake Naval Weapons Center, and testing and operations are being carried out by JPL.

  9. Extractive Deep Desulfurization of Liquid Fuels Using Lewis-Based Ionic Liquids

    Directory of Open Access Journals (Sweden)

    Swapnil A. Dharaskar

    2013-01-01

    Full Text Available A new class of green solvents, known as ionic liquids (ILs, has recently been the subject of intensive research on the extractive desulfurization of liquid fuels because of the limitation of traditional hydrodesulfurization method. In present work, eleven Lewis acid ionic liquids were synthesized and employed as promising extractants for deep desulfurization of the liquid fuel containing dibenzothiophene (DBT to test the desulfurization efficiency. [Bmim]Cl/FeCl3 was the most promising ionic liquid and performed the best among studied ionic liquids under the same operating conditions. It can remove dibenzothiophene from the model liquid fuel in the single-stage extraction process with the maximum desulfurization efficiency of 75.6%. It was also found that [Bmim]Cl/FeCl3 may be reused without regeneration with considerable extraction efficiency of 47.3%. Huge saving on energy can be achieved if we make use of this ionic liquids behavior in process design, instead of regenerating ionic liquids after every time of extraction.

  10. Lewis lung carcinoma regulation of mechanical stretch-induced protein synthesis in cultured myotubes.

    Science.gov (United States)

    Gao, Song; Carson, James A

    2016-01-01

    Mechanical stretch can activate muscle and myotube protein synthesis through mammalian target of rapamycin complex 1 (mTORC1) signaling. While it has been established that tumor-derived cachectic factors can induce myotube wasting, the effect of this catabolic environment on myotube mechanical signaling has not been determined. We investigated whether media containing cachectic factors derived from Lewis lung carcinoma (LLC) can regulate the stretch induction of myotube protein synthesis. C2C12 myotubes preincubated in control or LLC-derived media were chronically stretched. Protein synthesis regulation by anabolic and catabolic signaling was then examined. In the control condition, stretch increased mTORC1 activity and protein synthesis. The LLC treatment decreased basal mTORC1 activity and protein synthesis and attenuated the stretch induction of protein synthesis. LLC media increased STAT3 and AMP-activated protein kinase phosphorylation in myotubes, independent of stretch. Both stretch and LLC independently increased ERK1/2, p38, and NF-κB phosphorylation. In LLC-treated myotubes, the inhibition of ERK1/2 and p38 rescued the stretch induction of protein synthesis. Interestingly, either leukemia inhibitory factor or glycoprotein 130 antibody administration caused further inhibition of mTORC1 signaling and protein synthesis in stretched myotubes. AMP-activated protein kinase inhibition increased basal mTORC1 signaling activity and protein synthesis in LLC-treated myotubes, but did not restore the stretch induction of protein synthesis. These results demonstrate that LLC-derived cachectic factors can dissociate stretch-induced signaling from protein synthesis through ERK1/2 and p38 signaling, and that glycoprotein 130 signaling is associated with the basal stretch response in myotubes.

  11. Demência com corpos de Lewy: uma revisão para o psiquiatra Dementia with Lewy bodies: a review for psychiatrists

    Directory of Open Access Journals (Sweden)

    Almir Tavares

    2003-01-01

    Full Text Available A demência com corpos de Lewy (DCL tornou-se hoje uma entidade nosológica distinta, considerada por muitos autores a segunda causa principal de demência degenerativa, atrás apenas da doença de Alzheimer. Sua neuropatologia é caracterizada pela presença de corpos de Lewy tanto em regiões corticais como em áreas subcorticais do encéfalo. As principais manifestações clínicas incluem: declínio cognitivo progressivo, alucinações visuais recorrentes, flutuação no estado cognitivo e sinais parkinsonianos. Observa-se maior sensibilidade a efeitos indesejáveis de medicamentos neurolépticos e a resposta a medicações inibidoras da acetilcolinesterase é geralmente boa.Lewy body dementia became today a distinct nosological entity, considered by many authors the second cause of degenerative dementia, after Alzheimer's disease. Its neuropathology is caracterized by the presence of Lewy bodies both in cortical and subcortical areas of the brain. The main clinical manifestations are: progressive cognitive impairment, recurrent visual hallucinations, fluctuating cognitive status and parkinsonian signs. There is greater sensitivity to side effects of neuroleptic drugs and the response to cholinesterase inhibitors is generally good.

  12. The child labor in the United States by Lewis Hine’s lensO trabalho infantil nos Estados Unidos pelas lentes de Lewis Hine

    Directory of Open Access Journals (Sweden)

    José Pacheco dos Santos Júnior

    2013-04-01

    Full Text Available From the photographic production of Lewis Wickes Hine, this paper aims to discuss the use of photographic iconography for elucidating aspects of the history of child labor in the United States. Between 1908 and 1924, serving the National Child Labor Committee, Lewis Hine recorded and reported, through his camera, many faces of child labor in the USA and made a decisive contribution to the debate on the use of child labor in the contemporary world.A partir da produção fotográfica do estadunidense Lewis Wickes Hine, este trabalho vislumbra discutir a potencialidade do uso da iconografia fotográfica para a elucidação de aspectos da história do trabalho infantil nos Estados Unidos. Entre 1908 e 1924,a serviço do National Child Labor Committee, Lewis Hine registrou e denunciou através de sua câmera, as inúmeras faces do trabalho de crianças nos EUA e deu uma contribuição decisiva para o debate sobre o emprego do trabalho infantil no mundo contemporâneo.

  13. Lewis acid adducts of narrow band gap conjugated polymers.

    Science.gov (United States)

    Welch, Gregory C; Bazan, Guillermo C

    2011-03-30

    We report on the interaction of Lewis acids with narrow band gap conjugated copolymers containing donor and acceptor units. Examination of the widely used poly[(4,4-bis(2-ethylhexyl)cyclopenta-[2,1-b:3,4-b']dithiophene)-2,6-(diyl-alt-benzo[2,1,3]thiadiazole)-4,7-diyl] (1) shows weaker binding with B(C(6)F(5))(3) when compared with a small molecule that contains a cyclopenta-[2,1-b:3,4-b']dithiophene (CDT) unit flanked by two benzo[2,1,3]thiadiazole (BT) fragments. Studies on model compounds representative of 1, together with a comparison between B(C(6)F(5))(3) and BBr(3), indicate that the propensity for Lewis acid coordination is decreased because of steric encumbrance surrounding the BT nitrogen sites. These observations led to the design of chromophores that incorporate an acceptor unit with a more basic nitrogen site, namely pyridal[2,1,3]thiadiazole (PT). That this strategy leads to a stronger B-N interaction was demonstrated through the examination of the reaction of B(C(6)F(5))(3) with two small molecules bis(4,4-bis(hexyl)-4H-cyclopenta[2,1-b;3,4-b']dithiophene)-4,7-pyridal[2,1,3]thiadiazole (8) and bis{2-thienyl-(4,4-bis(hexyl)-4H-cyclopenta[2,1-b;3,4-b']dithiophene)}-4,7-pyridal[2,1,3]thiadiazole (9) and two polymer systems (poly[(4,4-bis(2-ethylhexyl)cyclopenta-[2,1-b:3,4-b']dithiophene)-2,6-diyl-alt-([1,2,5]thiadiazolo[3,4-c]pyridine)-4,7-diyl] (10) and poly[(4,4-bis(2-ethylhexyl)cyclopenta-[2,1-b:3,4-b']dithiophene)-2,6-diyl-alt-(4',7'-bis(2-thienyl)-[1,2,5]thiadiazolo[3,4-c]pyridine)-5,5-diyl] (11). From a materials perspective, it is worth pointing out that through the binding of B(C(6)F(5))(3), new NIR-absorbing polymers can be generated with band gaps from 1.31 to 0.89 eV. A combination of studies involving ultraviolet photoemission spectroscopy and density functional theory shows that the narrowing of the band gap upon borane coordination to the pyridal nitrogen on PT is a result of lowering the energies of both the highest occupied molecular

  14. Defining the recognition elements of Lewis Y-reactive antibodies.

    Directory of Open Access Journals (Sweden)

    Somdutta Saha

    Full Text Available Antibody response to carbohydrate antigens is often independent of T cells and the process of affinity/specificity improvement is considered strictly dependent on the germinal centers. Antibodies induced during a T cell-independent type 2 (TI-2 response are less variable and less functionally versatile than those induced with T cell help. The antigen specificity consequences of accumulation of somatic mutations in antibodies during TI-2 responses of Marginal Zone (MZ B cells is a fact that still needs explanation. Germline genes that define carbohydrate-reactive antibodies are known to sculpt antibody-combining sites containing innate, key side-chain contacts that define the antigen recognition step. However, substitutions associated with MZ B cell derived antibodies might affect the mobility and polyspecificity of the antibody. To examine this hypothesis, we analyzed antibodies reactive with the neolactoseries antigen Lewis Y (LeY to define the residue subset required for the reactive repertoire for the LeY antigen. Our molecular simulation studies of crystallographically determined and modeled antibody-LeY complexes suggests that the heavy-chain germline gene VH7183.a13.20 and the light-chain Vκ cr1 germline gene are sufficient to account for the recognition of the trisaccharide-H determinant Types 1-4, while the specificity for LeY is driven by the CDR3 backbone conformation of the heavy chain and not the side chain interactions. These results confirm that these monoclonals use germline-encoded amino acids to recognize simple carbohydrate determinants like trisaccharide-H but relies on somatic mutations in the periphery of the combining site to modify affinity for LeY through electrostatic interactions that leads to their optimized binding. These observations bring further attention to the role of mutations in T-cell independent antibodies to distinguish self from non-self carbohydrate antigens.

  15. Defining the Recognition Elements of Lewis Y-Reactive Antibodies

    Science.gov (United States)

    Saha, Somdutta; Pashov, Anastas; Siegel, Eric R.; Murali, Ramachandran; Kieber-Emmons, Thomas

    2014-01-01

    Antibody response to carbohydrate antigens is often independent of T cells and the process of affinity/specificity improvement is considered strictly dependent on the germinal centers. Antibodies induced during a T cell-independent type 2 (TI-2) response are less variable and less functionally versatile than those induced with T cell help. The antigen specificity consequences of accumulation of somatic mutations in antibodies during TI-2 responses of Marginal Zone (MZ) B cells is a fact that still needs explanation. Germline genes that define carbohydrate-reactive antibodies are known to sculpt antibody-combining sites containing innate, key side-chain contacts that define the antigen recognition step. However, substitutions associated with MZ B cell derived antibodies might affect the mobility and polyspecificity of the antibody. To examine this hypothesis, we analyzed antibodies reactive with the neolactoseries antigen Lewis Y (LeY) to define the residue subset required for the reactive repertoire for the LeY antigen. Our molecular simulation studies of crystallographically determined and modeled antibody-LeY complexes suggests that the heavy-chain germline gene VH7183.a13.20 and the light-chain Vκ cr1 germline gene are sufficient to account for the recognition of the trisaccharide-H determinant Types 1–4, while the specificity for LeY is driven by the CDR3 backbone conformation of the heavy chain and not the side chain interactions. These results confirm that these monoclonals use germline-encoded amino acids to recognize simple carbohydrate determinants like trisaccharide-H but relies on somatic mutations in the periphery of the combining site to modify affinity for LeY through electrostatic interactions that leads to their optimized binding. These observations bring further attention to the role of mutations in T-cell independent antibodies to distinguish self from non-self carbohydrate antigens. PMID:25117628

  16. Properties of lewis lung carcinoma cells surviving curcumin toxicity.

    Science.gov (United States)

    Yan, Dejun; Geusz, Michael E; Jamasbi, Roudabeh J

    2012-01-01

    The anti-inflammatory agent curcumin can selectively eliminate malignant rather than normal cells. The present study examined the effects of curcumin on the Lewis lung carcinoma (LLC) cell line and characterized a subpopulation surviving curcumin treatments. Cell density was measured after curcumin was applied at concentrations between 10 and 60 μM for 30 hours. Because of the high cell loss at 60 μM, this dose was chosen to select for surviving cells that were then used to establish a new cell line. The resulting line had approximately 20% slower growth than the original LLC cell line and based on ELISA contained less of two markers, NF-κB and ALDH1A, used to identify more aggressive cancer cells. We also injected cells from the original and surviving lines subcutaneously into syngeneic C57BL/6 mice and monitored tumor development over three weeks and found that the curcumin surviving-line remained tumorigenic. Because curcumin has been reported to kill cancer cells more effectively when administered with light, we examined this as a possible way of enhancing the efficacy of curcumin against LLC cells. When LLC cells were exposed to curcumin and light from a fluorescent lamp source, cell loss caused by 20 μM curcumin was enhanced by about 50%, supporting a therapeutic use of curcumin in combination with white light. This study is the first to characterize a curcumin-surviving subpopulation among lung cancer cells. It shows that curcumin at a high concentration either selects for an intrinsically less aggressive cell subpopulation or generates these cells. The findings further support a role for curcumin as an adjunct to traditional chemical or radiation therapy of lung and other cancers.

  17. Defining the recognition elements of Lewis Y-reactive antibodies.

    Science.gov (United States)

    Saha, Somdutta; Pashov, Anastas; Siegel, Eric R; Murali, Ramachandran; Kieber-Emmons, Thomas

    2014-01-01

    Antibody response to carbohydrate antigens is often independent of T cells and the process of affinity/specificity improvement is considered strictly dependent on the germinal centers. Antibodies induced during a T cell-independent type 2 (TI-2) response are less variable and less functionally versatile than those induced with T cell help. The antigen specificity consequences of accumulation of somatic mutations in antibodies during TI-2 responses of Marginal Zone (MZ) B cells is a fact that still needs explanation. Germline genes that define carbohydrate-reactive antibodies are known to sculpt antibody-combining sites containing innate, key side-chain contacts that define the antigen recognition step. However, substitutions associated with MZ B cell derived antibodies might affect the mobility and polyspecificity of the antibody. To examine this hypothesis, we analyzed antibodies reactive with the neolactoseries antigen Lewis Y (LeY) to define the residue subset required for the reactive repertoire for the LeY antigen. Our molecular simulation studies of crystallographically determined and modeled antibody-LeY complexes suggests that the heavy-chain germline gene VH7183.a13.20 and the light-chain Vκ cr1 germline gene are sufficient to account for the recognition of the trisaccharide-H determinant Types 1-4, while the specificity for LeY is driven by the CDR3 backbone conformation of the heavy chain and not the side chain interactions. These results confirm that these monoclonals use germline-encoded amino acids to recognize simple carbohydrate determinants like trisaccharide-H but relies on somatic mutations in the periphery of the combining site to modify affinity for LeY through electrostatic interactions that leads to their optimized binding. These observations bring further attention to the role of mutations in T-cell independent antibodies to distinguish self from non-self carbohydrate antigens.

  18. Research of Coal Mine Safety Administrative Penalties in Our Country%我国煤矿安全行政处罚问题研究

    Institute of Scientific and Technical Information of China (English)

    吴兵; 刘鸿义; 冯小燕; 苏赟

    2012-01-01

    科学认识煤矿安全行政处罚现状及存在的问题是目前我国煤矿安全立法、执法工作急需解决的重要问题之一。从我国煤矿安全行政处罚定义和要素着手,总结当前煤矿安全行政处罚特征,分析煤矿安全行政处罚存在的问题和薄弱环节,提出健全法律关系、完善煤矿安全行政处罚体系、增补行政处罚事项,赋予企业对员工安全处罚的权力等对策,为我国煤矿安全生产法律、法规的制定和煤矿安全行政处罚工作提供参考。%Scientific understanding status and problems of coal mine safety administrative penalties,it is one of the important issues for coal mine safety legislation and law enforcement which need to be resolved.In this paper it proceeds from definition and elements of coal mine safety administrative penalties in China,sums up the characteristics of the current coal mine safety administrative penalties,analyzes the problems and weaknesses of coal mine safety administrative penalties,puts forward the countermeasures which include perfecting legal relationship,improving coal mine safety administrative penalty system,adding items of administrative penalties,giving enterprises the powers to implement safety penalties for employees and so on.It provides references for the establishment of the laws and regulations for coal mine safety production and coal mine safety administrative penalties work.

  19. Research on the Categorization of Administrative Litigation in China%我国行政诉讼类型化研究

    Institute of Scientific and Technical Information of China (English)

    莫张勤

    2014-01-01

    目前,我国法律还没有确立行政诉讼的类型化,其不利后果表现为:不能全方位保障行政相对人的合法权益、不利于实现程序经济、不利于行政权与司法权之间矛盾的解决。我国学术界对于建立我国行政诉讼类型化有着多种观点与学说,其中,以“诉讼请求的内容”为划分标准的“三类说”最为可取。以“诉讼请求的内容”为划分标准,可将行政诉讼划分为:行政撤销诉讼、行政给付诉讼和行政确认诉讼三种基本类型。%At present,administrative litigation is not categorized in China,which causes serious problems in overall safeguarding legitimate rights and interests of the administrative counterpart,in achieving procedural economy,and in settling contradictions between executive power and jurisdiction. There are various views and theories in Chinese academia about the categonization of administrative litigation. Among them the most favorable is the“three-catego-ry” theory which takes litigation content as the criteria of categorization. According to the theory,administration liti-gation can be categorized into the following three categories:annulment of a specific administrative act,compensa-tion for infringement of the lawful rights and interests of a specific administrative counterpart,and verdict of whether a specific administrative act is legal or not.

  20. Nigeria Journal of Business Administration

    African Journals Online (AJOL)

    The Nigeria Journal of Business Administration has as its principal goal the promotion of academic excellence in research in the management sciences and the ... Articles are carefully selected to provide the reader with an analytical, ...

  1. Humanism, Administration and Education

    DEFF Research Database (Denmark)

    Plum, Maja

    2012-01-01

    Abstract Through the example of a Danish reform of educational plans in early childhood education, this paper analyses the emergence of a new pedagogical desire related to administrative educational reforms promoting accountability, visibility and documentation. Two arguments are made: first, it ...... the ‘professional nursery teacher’ is produced as a reflective daily researcher, who outlives her pedagogical desire as an analytical care for the optimisation of the ‘learning child’....

  2. Effectiveness of low-dose pregabalin in three patients with Lewy body disease and central neuropathic pain.

    Science.gov (United States)

    Ukai, Katsuyuki; Fujishiro, Hiroshige; Ozaki, Norio

    2017-03-01

    Many patients with Lewy body disease complain of pain, and their pain may be associated with this disease. Recently, pain has become a focus of attention in Parkinson's disease, but there is little information regarding pain in patients who have dementia with Lewy bodies. We used pregabalin to treat three Lewy body disease patients with chronic pain that may have been related to degeneration of central neurons. All three patients responded well to pregabalin at 25-50 mg/day. To our knowledge, there have been no previous reports of pregabalin showing efficacy for central neuropathic pain in Parkinson's disease or Lewy body disease.

  3. Research on Standardization Work of Administration Examination and Approval%行政审批标准化工作初探

    Institute of Scientific and Technical Information of China (English)

    陈丽君; 黄娟; 陈思嘉

    2014-01-01

    Based on the standard work on administration examination and approval in Guangdong, this paper discusses the construction thinking and structure of standards system for administration examination and approval, the development of the standards and several considerations during standards implementation.%本文以广东省行政审批标准工作实践为基础,探讨了行政审批标准体系构建的思路、体系结构框架,行政审批标准研制及实施过程中的几点考虑。

  4. Slow reactant-water exchange and high catalytic performance of water-tolerant Lewis acids.

    Science.gov (United States)

    Koito, Yusuke; Nakajima, Kiyotaka; Kobayashi, Hisayoshi; Hasegawa, Ryota; Kitano, Masaaki; Hara, Michikazu

    2014-06-23

    (31)P nuclear magnetic resonance (NMR) spectroscopic measurement with trimethylphosphine oxide (TMPO) was applied to evaluate the Lewis acid catalysis of various metal triflates in water. The original (31)P NMR chemical shift and line width of TMPO is changed by the direct interaction of TMPO molecules with the Lewis acid sites of metal triflates. [Sc(OTf)3] and [In(OTf)3] had larger changes in (31)P chemical shift and line width by formation of the Lewis acid-TMPO complex than other metal triflates. It originates from the strong interaction between the Lewis acid and TMPO, which results in higher stability of [Sc(OTf)3TMPO] and [In(OTf)3TMPO] complexes than other metal triflate-TMPO complexes. The catalytic activities of [Sc(OTf)3] and [In(OTf)3] for Lewis acid-catalyzed reactions with carbonyl compounds in water were far superior to the other metal triflates, which indicates that the high stability of metal triflate-carbonyl compound complexes cause high catalytic performance for these reactions. Density functional theory (DFT) calculation suggests that low LUMO levels of [Sc(OTf)3] and [In(OTf)3] would be responsible for the formation of stable coordination intermediate with nucleophilic reactant in water. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Intramolecular Lewis pairs with two acid sites - reactivity differences between P- and N-based systems.

    Science.gov (United States)

    Körte, Leif A; Blomeyer, Sebastian; Heidemeyer, Shari; Nissen, Jan Hendrick; Mix, Andreas; Neumann, Beate; Stammler, Hans-Georg; Mitzel, Norbert W

    2016-11-01

    The doubly acid-functionalised aniline PhN[(CH2)3B(C6F5)2]2 shows rapidly exchanging boron acid groups at the central base function and is an active frustrated Lewis pair due to cooperative hydride binding by both Lewis acids. Here we report investigations on the effect of different substituents at the central nitrogen atom and on the effect of exchanging nitrogen by phosphorus. Treatment of diallyl-tert-butylaniline with one equivalent of HB(C6F5)2 led to formation of a seven-membered iminium hydridoborate ring; after mono-hydroboration the intermediately formed frustrated Lewis pair reacts with the second allylamine function under ring closure. Phosphorus based Lewis pairs with two acid sites were prepared by hydroboration of diallylphenylphosphane and diallyl-tert-butylphosphane. Unlike the aniline PhN[(CH2)3B(C6F5)2]2 the doubly hydroborated species ((t)Bu/Ph)P[(CH2)3B(C6F5)2]2 show no dynamic exchange of the boron Lewis acid functions in solution and are not catalytically active in terms of H/D-scrambling as well as hydrogenation reactions. Quantum-chemical investigations revealed the B-P bond dissociation Gibbs free energy to be much larger than those of the nitrogen analogue. The absence of an active open form in solution prevents an activity in heterolytic hydrogen splitting.

  6. Unusual doping of donor-acceptor-type conjugated polymers using lewis acids.

    Science.gov (United States)

    Poverenov, Elena; Zamoshchik, Natalia; Patra, Asit; Ridelman, Yonatan; Bendikov, Michael

    2014-04-02

    Conjugated polymers that can undergo unusual nonoxidative doping were designed. A series of polymers based on donor-acceptor-donor (DAD) moieties 2,1,3-benzoselenadiazole, 2,1,3-benzothiadiazole, 2,1,3-benzoxadiazolebenzo[2,1,5]oxodiazole, and 2-hexylbenzotriazole as acceptor fragments and 3,4-ethylenedioxyselenophene (EDOS) and 3,4-ethylenedioxythiophene (EDOT) as donor fragments was prepared. When the studied polymers were reacted with Lewis acids and bases, notable optical switching and conductivity changes were observed, evidencing the exceptional case of efficient nonoxidative doping/dedoping. Remarkably, in previously reported works, coordination of Lewis acids causes band gap shift but not doping of the conductive polymer, while in the present study, coordination of Lewis acid to highly donating EDOT and EDOS moieties led to polymer doping. The polymers show remarkable stability after numerous switching cycles from neutral to doped states and vice versa and can be switched both electrochemically and chemically. The reactivity of the prepared polymers with Lewis acids and bases of different strengths was studied. Calculation studies of the Lewis acid coordination mode, its effect on polymer energies and band gap, support the unusual doping. The reported doping approach opens up the possibility to control the conjugation, color change, and switching of states of conjugated polymers without oxidation.

  7. Stochastic Modeling of Rainfall in Peninsular Malaysia Using Bartlett Lewis Rectangular Pulses Models

    Directory of Open Access Journals (Sweden)

    Ibrahim Suliman Hanaish

    2011-01-01

    Full Text Available Three versions of Bartlett Lewis rectangular pulse rainfall models, namely, the Original Bartlett Lewis (OBL, Modified Bartlett Lewis (MBL, and 2N-cell-type Bartlett Lewis model (BL2n, are considered. These models are fitted to the hourly rainfall data from 1970 to 2008 obtained from Petaling Jaya rain gauge station, located in Peninsular Malaysia. The generalized method of moments is used to estimate the model parameters. Under this method, minimization of two different objective functions which involve different weight functions, one weight is inversely proportional to the variance and another one is inversely proportional to the mean squared, is carried out using Nelder-Mead optimization technique. For the purpose of comparison of the performance of the three different models, the results found for the months of July and November are used for illustration. This performance is assessed based on the goodness of fit of the models. In addition, the sensitivity of the parameter estimates to the choice of the objective function is also investigated. It is found that BL2n slightly outperforms OBL. However, the best model is the Modified Bartlett Lewis MBL, particularly when the objective function considered involves weight which is inversely proportional to the variance.

  8. Role of the Lewis and ABO Blood Group Antigens in Helicobacter pylori Infection.

    Science.gov (United States)

    Keramati, Mohammad Reza; Sadeghian, Mohammad Hadi; Ayatollahi, Hosein; Badiee, Zahra; Shakibayi, Hosein; Moghimi-Roudi, Ali

    2012-07-01

    Helicobacter pylori infection is a major risk factor for chronic gastritis and gastric cancer. Some findings show increased frequencies of these diseases in individuals with type O blood and in secretors (expressing Le(b) antigen), but other studies have not found any relationship between blood groups and this infection. Given that H. pylori infection and gastric cancer are common in Iran, the assessment of the pathogenesis of this infection in relation to these blood groups could be valuable. In a cross-sectional study, we determined the ABO and Lewis blood groups of participants using the tube method and evaluated the level of anti-H. pylori immunoglobulin G using an enzyme-linked immunosorbent assay. This study included 171 Iranian blood donors from Mashhad, Iran, during 2010. The significance of the differences in the frequencies of the Lewis and ABO phenotypes between individuals infected with and without H. Pylori infection were tested using the Chi-square test. A P-value ABO blood group was O (33.9%), and the most common Lewis blood group was Le(a-b+) (54.7%). The frequencies of the ABO, Lewis, and secretion phenotypes were not significantly different between the infected and uninfected subjects. We did not find any significant relationship between the Lewis, ABO, and secretion phenotypes and H. pylori infection.

  9. Three pioneers of comparative psychology in America, 1843-1890: Lewis H. Morgan, John Bascom, and Joseph LeConte.

    Science.gov (United States)

    Johnston, Timothy D

    2003-02-01

    Scientific comparative psychology in America dates from the mid-1890s, but there is a body of earlier literature on the topic, written during a period of theistic debates over Darwinian evolution. The anthropologist Lewis H. Morgan rejected instinct as an explanation of animal behavior in 1843 and defended the mental similarities between animals and humans, although he was not an evolutionist. John Bascom's textbook Comparative Psychology (1878) is the earliest American work to use that title, and its theistic approach anticipates some arguments found in much later evolutionary works. Beginning in 1860, the geologist Joseph LeConte, who is well known for defending the compatibility of evolution and religion, wrote several articles in which he outlined a comparative evolutionary approach to psychological problems. However, these writers did not establish a coherent research tradition and were ignored by the "New Psychologists" of the 1880s.

  10. Comparing Cognitive Profiles of Licensed Drivers with Mild Alzheimer’s Disease and Mild Dementia with Lewy Bodies

    Directory of Open Access Journals (Sweden)

    Stephanie Yamin

    2016-01-01

    Full Text Available Purpose. Alzheimer’s disease (AD and dementia with Lewy Bodies (DLB constitute two of the most common forms of dementia in North America. Driving is a primary means of mobility among older adults and the risk of dementia increases with advanced age. The purpose of this paper is to describe the cognitive profile of licensed drivers with mild AD and mild DLB. Method. Licensed drivers with mild AD, mild DLB, and healthy controls completed neuropsychological tests measuring general cognition, attention, visuospatial/perception, language, and cognitive fluctuations. Results. The results showed differences between healthy controls and demented participants on almost all neuropsychological measures. Participants with early DLB were found to perform significantly worse on some measures of attention and visuospatial functioning in comparison with early AD. Discussion. Future research should examine the relationship between neuropsychological measures and driving outcomes among individuals with mild AD and mild DLB.

  11. Research on the Perfect Administration of Government Establishment%政府机构编制管理健全探析

    Institute of Scientific and Technical Information of China (English)

    邓勇; 周永胜

    2011-01-01

    Nowadays many illegal phenomenon occur through the process of administration of government establishment with a lot bad consequences to governmental construction and management. In this paper, the author thoroughly analyzes reasons behind the present situation of the administration of government establishment and puts forward specific countermeasures for perfect administration of government establishment according to the fundamentally administrative principle of scientification, standardization and legalization.%当前政府机构编制管理中出现许多违法现象,给政府机构建设和管理工作带来诸多不良后果。本文分析造成政府机构编制管理现状的原因,在坚持政府机构编制科学化、规范化和法制化管理的基本原则下,提出了健全政府机构编制管理的具体对策。

  12. Administration of Anesthesia

    Science.gov (United States)

    ... a Surgeon What We Do Administration of Anesthesia Administration of Anesthesia Oral and maxillofacial surgeons are extensively ... Injury Wisdom Teeth Management Procedures Administration of Anesthesia Administration of Anesthesia Oral and maxillofacial surgeons are extensively ...

  13. On Cultivation Mechanism of Scientific Research Innovation Capacity for the Postgraduates of Public Administration%公共管理学科研究生科研创新能力培养机制与路径选择

    Institute of Scientific and Technical Information of China (English)

    罗依平; 甘纪平; 范娜

    2011-01-01

    公共管理学科研究生科研创新能力的培养是公共管理学科研究生教育的核心内容,也是培养高层次公共管理人才的必然要求。本文在分析公共管理学科研究生科研创新能力培养机制内涵的基础上,提出了构建公共管理学科研究生科研创新能力培养机制的有效路径。%The cultivation of scientific research innovation capacity for the postgraduate of public management discipline is not only the core subject for education of the postgraduates of public administration,but also the inevitable requirement to develop high--level public administration talent. By analyzing the meaning of cultivation mechanism of scientific-- research innovation capacity for the postgraduate of public administration, the measures for building the cultivation mechanism of scientific-- re- search innovation capacity for the postgraduate of public administration discipline are put forward.

  14. Imaging amyloid in Parkinson's disease dementia and dementia with Lewy bodies with positron emission tomography.

    Science.gov (United States)

    Brooks, David J

    2009-01-01

    Although Parkinson's disease with later dementia (PDD) and dementia with Lewy bodies (DLB) are pathologically characterized by the presence of intraneuronal Lewy inclusion bodies, amyloid deposition is also associated to varying degrees with both these disorders. Fibrillar amyloid load can now be quantitated in vivo with positron emission tomography (PET) using imaging biomarkers. Here the reported findings of 11C-PIB PET studies concerning the amyloid load associated with PD and its influence on dementia are reviewed. It is concluded that the presence of amyloid acts to accelerate the dementia process in Lewy body disorders, though has little influence on its nature. Anti-amyloid strategies could be a relevant approach for slowing dementia in a number of DLB and PDD cases.

  15. Polyfunctional Lewis acids: intriguing solid-state structure and selective detection and discrimination of nitroaromatic explosives.

    Science.gov (United States)

    Swamy P, Chinna Ayya; Thilagar, Pakkirisamy

    2015-06-08

    Synthesis and crystal structures of three porphyrin-based polyfunctional Lewis acids 1-3 are reported. Intermolecular HgCl⋅⋅⋅HgCl (linear and μ-type) interactions in the solid state of the peripherally ArHgCl-decorated compound 3 lead to a fascinating 3D supramolecular architecture. Compound 3 shows a selective fluorescence quenching response to picric acid and discriminates other nitroaromatic-based explosives. For the first time, an electron-deficient polyfunctional Lewis acid is shown to be useful for the selective detection and discrimination of nitroaromatic explosives. The Stern-Volmer quenching constant and detection limits of compound 3 for picric acid are the best among the reported small-molecular receptors for nitroaromatic explosives. The electronic structure, Lewis acidity, and selective sensing characteristics of 3 are well corroborated by DFT calculations. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. On the behaviour of biradicaloid [P(μ-NTer)]2 towards Lewis acids and bases.

    Science.gov (United States)

    Hinz, Alexander; Schulz, Axel; Villinger, Alexander

    2016-05-07

    The well-known diphosphadiazane-1,3-diyl [P(μ-NTer)]2 (Ter = 2,6-bis(2,4,6-trimethyl-phenyl)-phenyl) was treated with Lewis bases such as N-heterocyclic carbenes and Lewis acids e.g. gold(i) chloride complexes. In the reaction with the Lewis base, fragmentation of the P2N2 framework was observed, yielding a salt of the type [(NHC)2P](+)[(TerN)2P](-) in a clean reaction. The reaction of [P(μ-NTer)]2 with gold(i) chloride afforded 1 : 1 and 1 : 2 complexes. The dinuclear complex [(ClAu)2P(μ-NTer)2P] displays a bridging P atom between both gold centers, as has been observed for P based zwitterions.

  17. Composition, texture and methane potential of cellulosic residues from Lewis acids organosolv pulping of wheat straw.

    Science.gov (United States)

    Constant, Sandra; Barakat, Abdellatif; Robitzer, Mike; Di Renzo, Francesco; Dumas, Claire; Quignard, Françoise

    2016-09-01

    Cellulosic pulps have been successfully isolated from wheat straw through a Lewis acids organosolv treatment. The use of Lewis acids with different hardness produced pulps with different delignification degrees. The cellulosic residue was characterised by chemical composition, X-ray diffraction, FT-IR spectroscopy, N2 physisorption, scanning electron microscopy and potential for anaerobic digestibility. Surface area and pore volume increased with the hardness of the Lewis acid, in correspondence with the decrease of the amount of lignin and hemicellulose in the pulp. The non linearity of the correlation between porosity and composition suggests that an agglomeration of cellulose fibrils occurs in the early stages of pulping. All organosolv pulps presented a significantly higher methane potential than the parent straw. A methane evolution of 295Ncm(3)/g OM was reached by a moderate improvement of the accessibility of the native straw.

  18. Dementia with lewy bodies: diagnosis and management for primary care providers.

    Science.gov (United States)

    Zupancic, Melanie; Mahajan, Aman; Handa, Kamna

    2011-01-01

    The purpose of this review is to aid primary care providers in distinguishing dementia with Lewy bodies (DLB) from Alzheimer's disease and from Parkinson's disease with dementia. Differentiating these entities has important treatment implications. A PubMed search was undertaken using the keywords Lewy body dementia, dementia with Lewy bodies, and Lewy body disease. There were no date restrictions. Only articles in the English language were reviewed. References of selected articles were reviewed for additional sources. Initially, 2,967 articles were retrieved. All 3 authors participated in data selection and extraction. Articles were further selected for content specific to epidemiology, clinical presentation, diagnostic studies, treatment, and prognosis. For articles with repetitive information, the most current article was used. This resulted in a total of 62 articles included in the review. Dementia with Lewy bodies is the second leading cause of dementia after Alzheimer's disease. The core symptoms of DLB, including cognitive fluctuations, visual hallucinations, and parkinsonism, may not always be present as a triad, and clinicians may be unaware of associated symptoms. Thus, this diagnosis is frequently missed by primary care providers. Often, DLB is misdiagnosed as Alzheimer's disease, Parkinson's disease, or a primary psychiatric illness. Treatments for DLB include cholinesterase inhibitors and N-methyl-D-aspartate antagonists. Antipsychotics should be avoided or used with caution. Dementia with Lewy bodies is an often missed diagnosis. Symptoms are often attributed to other disorders. A high clinical suspicion is helpful in accurate diagnosis, and presence of any of the core symptoms should initiate clinical suspicion of DLB. Distinguishing DLB from other disorders has important treatment implications.

  19. Two-Stage Indicators to Assess Learning Curves for Minimally Invasive Ivor Lewis Esophagectomy.

    Science.gov (United States)

    Wang, Qi; Wu, Zixiang; Chen, Gang; Zhang, Sai; Shen, Gang; Wu, Ming

    2016-10-05

    Background Minimally invasive esophagectomy (MIE) Ivor Lewis has been increasingly performed over the last two decades. To guide the implementation of this technically demanding procedure, a comprehensive assessment of MIE-Ivor Lewis learning curves should include both the general competence to accomplish the procedure and the ability to generate oncological benefits. These objectives are believed to be associated with different phases of the learning curve. Methods A retrospective review of the first 109 patients who underwent MIE-Ivor Lewis by a single qualified surgeon was conducted. Relevant variables were collected and assessed by regression analysis to identify suitable indicators for patient stratification and learning curve assessment. Thereafter, the differential analysis was performed among groups to validate the learning curve model. Results Two variables, intrathoracic gastroesophageal anastomosis time and bilateral recurrent laryngeal nerve (RLN) lymphadenectomy number, which plateaued, respectively, after the 26th and 88th cases, were selected as meaningful indicators to identify different competence levels. Therefore, 109 patients were chronologically subcategorized into three groups (the first 26 MIEs as the early group, the next 62 cases as the middle group, and 21 most recent cases as the late group). Perioperative data were compared between groups with positive results to indicate a three-phase model for a learning curve for MIE-Ivor Lewis. Conclusions An MIE-Ivor Lewis learning curve should include three discrete phases that indicate, successively, unskilled operation (general competence to accomplish, less proficiency), surgical proficiency, and oncological efficacy. Intrathoracic anastomosis time and bilateral RLN lymphadenectomy were identified as suitable indicators delineate the different stages of an MIE-Ivor Lewis learning curve.

  20. Normotension in Lewis and Dahl salt-resistant rats is governed by different genes.

    Science.gov (United States)

    Crespo, Kimberley; Chauvet, Cristina; Blain, Marilyne; Ménard, Annie; Roy, Julie; Deng, Alan Y

    2011-03-01

    Inbred rodent models simulating essential hypertension and normotension are useful tools in discovering genes controlling blood pressure (BP) homeostasis. An analysis of a F2 population made from crosses of hypertensive Dahl salt-sensitive (DSS) and normotensive Lewis rats did not detect a BP quantitative trait locus (QTL) on chromosome 7 (Chr 7). However, false negativity could not be excluded. If a BP QTL could be proven to exist, what gene(s) may be responsible for this QTL. We first constructed reciprocal congenic strains for a Chr 7 segment and determined functional domains of prominent candidate genes. A congenic strain made in the DSS rat background exhibited a BP effect, indicating that a BP QTL, C7QTL, inhabits Chr 7. Contrarily, a congenic strain constructed in the Lewis rat background did not change BP, demonstrating a dependence of C7QTL on the DSS rats environment. Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats. In contrast, the Lewis alleles of 11-beta-hydroxylase (Cyp11b1), aldosterone synthase (Cyp11b2) and Cytochrome P-450 11B3 (Cyp11b3) are identical to those of DSS rats, but different from those of DSR rats. Thus, the failure to detect a linkage between a Chr 7 segment and BP in F2(DSS × Lewis) can be attributed to false negativity. Tac2, Nxph4 and Rdh2 are priority candidate genes for C7QTL. Lewis and DSR rats are both normotensive, but their underlying genetic determinants are different.

  1. Safety management of complex research operations

    Science.gov (United States)

    Brown, W. J.

    1981-01-01

    Complex research and technology operations present many varied potential hazards which must be addressed in a disciplined independent safety review and approval process. The research and technology effort at the Lewis Research Center is divided into programmatic areas of aeronautics, space and energy. Potential hazards vary from high energy fuels to hydrocarbon fuels, high pressure systems to high voltage systems, toxic chemicals to radioactive materials and high speed rotating machinery to high powered lasers. A Safety Permit System presently covers about 600 potentially hazardous operations. The Safety Management Program described in this paper is believed to be a major factor in maintaining an excellent safety record at the Lewis Research Center.

  2. Taking a Stand for Children Through Lewis Hine’s Lens

    Directory of Open Access Journals (Sweden)

    Frédéric Perrier

    2007-01-01

    Full Text Available Benjamin Kwan and Christopher Nguyen are 14 and study at Irvine, CA, Lakeside Middle School, Jon Pang, U.S.A. They competed for the National History Day Junior Group Documentary Prize, and placed first at the State level and sixth at Nationals with their ten minute-film: “Taking a Stand for Children Through Lewis Hine’s Lens”.Their documentary concentrates on Lewis W. Hine’s crusade against child-labor with the National Child Labor Committee [1906-1918] and shows how he conducted thorough inv...

  3. Structural diversity and biological importance of ABO, H, Lewis and secretor histo-blood group carbohydrates.

    Science.gov (United States)

    de Mattos, Luiz Carlos

    ABO, H, secretor and Lewis histo-blood system genes control the expression of part of the carbohydrate repertoire present in areas of the body occupied by microorganisms. These carbohydrates, besides having great structural diversity, act as potential receptors for pathogenic and non-pathogenic microorganisms influencing susceptibility and resistance to infection and illness. Despite the knowledge of some structural variability of these carbohydrate antigens and their polymorphic levels of expression in tissue and exocrine secretions, little is known about their biological importance and potential applications in medicine. This review highlights the structural diversity, the biological importance and potential applications of ABO, H, Lewis and secretor histo-blood carbohydrates.

  4. Lewis Acid Triggered Regioselective Magnesiation and Zincation of Uracils, Uridines, and Cytidines.

    Science.gov (United States)

    Klier, Lydia; Aranzamendi, Eider; Ziegler, Dorothée; Nickel, Johannes; Karaghiosoff, Konstantin; Carell, Thomas; Knochel, Paul

    2016-03-04

    The Lewis acid MgCl2 allows control of the metalation regioselectivity of uracils and uridines. In the absence of the Lewis acid, metalation of uracil and uridine derivatives with TMPMgCl·LiCl occurs at the position C(5). In the presence of MgCl2, zincation using TMP2Zn·2LiCl·2MgCl2 occurs at the position C(6). This metalation method provides easy access to functionalized uracils and uridines. Using TMP2Zn·2LiCl·2MgCl2 also allows to functionalize cytidine derivatives at the position C(6).

  5. Cooperative Catalysis of Combined Systems of Transition-Metal Complexes with Lewis Acids: Theoretical Understanding.

    Science.gov (United States)

    Guan, Wei; Zeng, Guixiang; Kameo, Hajime; Nakao, Yoshiaki; Sakaki, Shigeyoshi

    2016-10-01

    The combination of transition-metal complexes and Lewis acids has been recently applied to several catalytic reactions, in which the Lewis acid plays a crucial role as a non-innocent additive to accelerate the reaction. In this review article, the reasons for the acceleration by the Lewis acid are discussed based on our recent theoretical studies. In the H-H σ-bond activation of a dihydrogen molecule by a nickel(0)-borane complex, the empty p orbital of the borane moiety interacts with the H-H σ bonding MO to form charge transfer (CT) from the dihydrogen molecule to the borane moiety to accelerate the reaction. In the B-F σ-bond activation of BF3 by a platinum(0)-bisphosphine complex, the second BF3 molecule interacts with the F atom that is dissociating from the B atom to stabilize the transition state and product by the CT from the F atom to the second BF3 . In this reaction, the substrate BF3 plays a crucial role as the Lewis acid to accelerate the activation of the B-F σ bond. In the nickel-catalyzed decyanative coupling of arylcarboxybenzonitriles with acetylenes, two molecules of the aluminum Lewis acid interact with the cyano N atom and the carbonyl O atom of the substrate to stabilize the transition state and intermediate. In the nickel-catalyzed alkylation of aromatic amides with alkenes, the Lewis acid enhances the para regioselectivity of alkylation by interacting with the carbonyl O atom. In the nickel-catalyzed carboxylation of sp(3) carbon and sp carbon atoms with carbon dioxide, not the σ-bond activation but the insertion reaction of carbon dioxide into the metal-carbon bond is accelerated by the Lewis acid by interacting with the O atom of carbon dioxide, because the CT from the metal-carbon bond to carbon dioxide is enhanced by the interaction. This theoretical knowledge suggests that the combination of transition-metal complex and Lewis acid can broaden the application range of transition-metal complex as catalyst. © 2016 The Chemical

  6. Polimorfismo dos genes ABO, Lewis e Secretor correlacionados com o câncer de mama

    OpenAIRE

    Gradella, Débora Barreto Teresa [UNESP

    2007-01-01

    A expressão de antígenos ABH e Lewis tem sido associada com o desenvolvimento e prognóstico do câncer, diferenciação tumoral e metástase. Considerando que o carcinoma ductal invasivo (CADI) de mama apresenta múltiplas alterações, o objetivo deste estudo foi avaliar se o polimorfismo dos genes ABO, Lewis e Secretor, bem como a fenotipagem ABO podem estar associados ao câncer de mama e com parâmetros anatomoclínicos do tumor. Foram avaliadas 76 mulheres portadoras de CADI e 78 mulheres doadoras...

  7. The Research of the Connection between Administration Corruption and System in China%中国的行政腐败与制度关系研究

    Institute of Scientific and Technical Information of China (English)

    李瑞清; 李蓉蓉

    2009-01-01

    This text analyzes the system of administration corruption,and then discusses the present condition and the relation between administration corruption and system restritction in our country.On the basis of these,it also puts forward some ways to solve the problem of administration corruption.%腐败是现代社会发展的毒瘤,反腐败对于社会的稳定和国家的长治久安具有重要的意义腐败的根源在于制度的缺陷,只有坚持制度的建设和创新,才能从源头上遏制腐败现象的蔓延.本文通过对我国行政腐败的制度分析,探讨了我国行政腐败与制度约束的关系,提出了健全和完善制度约束的一些设想.

  8. Development of a new Lewis base-tolerant chiral LBA and its application to catalytic asymmetric protonation reaction†

    OpenAIRE

    Cheon, Cheol Hong; Imahori, Tatsushi; Yamamoto, Hisashi

    2010-01-01

    A new Lewis base-tolerant LBA (Lewis Acid Assisted Brønsted Acid) derived from La(OTf)3 and (S)-HOP has been developed as a new chiral Brønsted acid. This acid has been successfully applied as a catalyst to asymmetric protonation reactions of silyl enol ethers of 2-substituted cyclic ketones.

  9. Unraveling the Complexities: An Investigation of the Factors That Induce Load in Chemistry Students Constructing Lewis Structures

    Science.gov (United States)

    Tiettmeyer, Jessica M.; Coleman, Amelia F.; Balok, Ryan S.; Gampp, Tyler W.; Duffy, Patrick L.; Mazzarone, Kristina M.; Grove, Nathaniel P.

    2017-01-01

    Mastering the ability to construct and manipulate Lewis structures is an important first step along the journey to reaching representational competence. Lewis structures serve as a convenient organizational scheme that can help students to scaffold their chemical knowledge and help them to apply it to predict a variety of physical and chemical…

  10. Lewis base catalyzed [4+2] annulation of electron-deficient chromone-derived heterodienes and acetylenes.

    Science.gov (United States)

    Dückert, Heiko; Khedkar, Vivek; Waldmann, Herbert; Kumar, Kamal

    2011-04-26

    Lewis base catalyzed [4+2] annulation reactions between electron-deficient chromone oxa- and azadienes and acetylene carboxylates provide tricyclic benzopyrones inspired by natural products. An asymmetric synthesis of the tricyclic benzopyrones was developed by using modified cinchona alkaloids as enantiodifferentiating Lewis base catalysts.

  11. "OrganicPad": An Interactive Freehand Drawing Application for Drawing Lewis Structures and the Development of Skills in Organic Chemistry

    Science.gov (United States)

    Cooper, Melanie M.; Grove, Nathaniel P.; Pargas, Roy; Bryfczynski, Sam P.; Gatlin, Todd

    2009-01-01

    Lewis structures are important for learning chemistry as they serve as an essential link between the structure of chemical compounds and their function. Unfortunately, the creation of valid Lewis structures remains an elusive goal for many students. In recent years, several web-based programs have been created that allow students to receive…

  12. Chemical, biomedical and ecological studies of SRC-I materials from the Fort Lewis Pilot Plant: a status report

    Energy Technology Data Exchange (ETDEWEB)

    Mahlum, D.D. (ed.)

    1981-01-01

    This document discusses studies performed with solvent refined coal (SRC) materials obtained from the Fort Lewis Pilot Plant during operation in the SRC-I mode. The development of analytical methodology is presented as well as results obtained from the application of these methods to light oil (LO), wash solvent (WS) and process solvent (PS). Results of cellular and animal studies with LO, WS and PS are included, along with a description of methods for the generation and characterization of LO and PS aerosols, and for exposing rats, mice and guinea pigs to these aerosols. The effects of SRC-I product on seed germination and plant growth which have also been studied are discussed. The SRC-I product, feed coal and the mineral residue have been analyzed for organic and inorganic constituents. The higher-boiling-point material, PS, exhibited significant mutagenic activity in the Ames assay; LO and WS were inactive. Process solvent also caused transformation of cultured Syrian hamster embryo cells. Additional chemical fractionation studies suggest that primary aromatic amines are major determinants of the observed mutagenic activity. Skin-painting studies with SRC-II naphtha, heavy distillate, shale oil and petroleum crude indicate a good correlation between the results of the cellular assays and skin carcinogenesis in mice. Wash solvent was more toxic after oral administration to rats than was light oil or process solvent. The effects of LO, WS and PS on development were studied after administration to pregnant rats. The tissue distribution of a number of components of PS was studied after oral administration of PS to rats. The effect of SRC-I product on the germination and growth of barley was investigated by mixing or layering the product with soil and placing the mixture in a field lysimeter.

  13. AV-1451 tau and β-amyloid positron emission tomography imaging in dementia with Lewy bodies.

    Science.gov (United States)

    Kantarci, Kejal; Lowe, Val J; Boeve, Bradley F; Senjem, Matthew L; Tosakulwong, Nikki; Lesnick, Timothy G; Spychalla, Anthony J; Gunter, Jeffrey L; Fields, Julie A; Graff-Radford, Jonathan; Ferman, Tanis J; Jones, David T; Murray, Melissa E; Knopman, David S; Jack, Clifford R; Petersen, Ronald C

    2017-01-01

    Patients with probable dementia with Lewy bodies (DLB) often have Alzheimer's disease (AD)-related pathology. Our objective was to determine the pattern of positron emission tomography (PET) tau tracer AV-1451 uptake in patients with probable DLB, compared to AD, and its relationship to β-amyloid deposition on PET. Consecutive patients with clinically probable DLB (n = 19) from the Mayo Clinic Alzheimer's Disease Research Center underwent magnetic resonance imaging, AV-1451, and Pittsburgh compound-B (PiB) PET examinations. Age- and sex-matched groups of AD dementia (n = 19) patients and clinically normal controls (n = 95) from an epidemiological cohort served as a comparison groups. Atlas- and voxel-based analyses were performed. The AD dementia group had significantly higher AV-1451 uptake than the probable DLB group, and medial temporal uptake completely distinguished AD dementia from probable DLB. Patients with probable DLB had greater AV-1451 uptake in the posterior temporoparietal and occipital cortex compared to clinically normal controls, and in probable DLB, the uptake in these regions correlated with global cortical PiB uptake (Spearman rho = 0.63; p = 0.006). Medial temporal lobe AV-1451 uptake distinguishes AD dementia from probable DLB, which may be useful for differential diagnosis. Elevated posterior temporoparietal and occipital AV-1451 uptake in probable DLB and its association with global cortical PiB uptake suggest an atypical pattern of tau deposition in DLB. ANN NEUROL 2017;81:58-67. © 2016 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.

  14. Delirium and dementia with Lewy bodies: distinct diagnoses or part of the same spectrum?

    Science.gov (United States)

    Gore, Rachel L; Vardy, Emma R L C; O'Brien, John T

    2015-01-01

    Dementia with Lewy bodies (DLB) is recognised as the second most common form of dementia in older people. Delirium is a condition of acute brain dysfunction for which a pre-existing diagnosis of dementia is a risk factor. Conversely delirium is associated with an increased risk of developing dementia. The reasons for this bidirectional relationship are not well understood. Our aim was to review possible similarities in the clinical presentation and pathophysiology between delirium and DLB, and explore possible links between these diagnoses. A systematic search using Medline, Embase and Psychinfo was performed. References were scanned for relevant articles, supplemented by articles identified from reference lists and those known to the authors. 94 articles were selected for inclusion in the review. Delirium and DLB share a number of clinical similarities, including global impairment of cognition, fluctuations in attention and perceptual abnormalities. Delirium is a frequent presenting feature of DLB. In terms of pathophysiological mechanisms, cholinergic dysfunction and genetics may provide a common link. Neuroimaging studies suggest a brain vulnerability in delirium which may also occur in dementia. The basal ganglia, which play a key role in DLB, have also been implicated in delirium. The role of Cerebrospinal fluid (CSF) and serum biomarkers for both diagnoses is an interesting area although some results are conflicting and further work in this area is needed. Delirium and DLB share a number of features and we hypothesise that delirium may, in some cases, represent early or 'prodromal' DLB. Further research is needed to test the novel hypothesis that delirium may be an early marker for future DLB, which would aid early diagnosis of DLB and identify those at high risk.

  15. Economic Analysis of Family Housing at Fort Lewis, Washington.

    Science.gov (United States)

    1985-01-01

    includes land cost based on local market value for residential subdivision land in Pierce and Thurston Counties X (2) Contract administration cost...A review of inflation guidelines indicated that the same escala - tion rate was applicable to all cost items and, therefore, differential infla- tion...economies of Pierce and Thurston Counties. It would be particu-I larly beneficial to the hard pressed construction industry where the November 1984

  16. Senior Administrators Should Have Administrative Contracts.

    Science.gov (United States)

    Posner, Gary J.

    1987-01-01

    Recognizing that termination is viewed by the employee as the equivalent to capital punishment of a career, an administrative contract can reduce the emotional and financial entanglements that often result. Administrative contracts are described. (MLW)

  17. Emotional Intelligence in School Administrators

    Directory of Open Access Journals (Sweden)

    Emine BABAOĞLAN

    2010-04-01

    Full Text Available One of the variables that affects success in business life is emotional intelligence of working people. The purpose of this research is to identify whether the school administrators’ emotional intelligence scores differ meaningfully according to their gender, marital status, branch, being a principal or assistant principal, being elementary school administrator or high school administrator, having manegerial education course or not, educational background, period of occupational service, age, length of administration service, number of children. 180 administrators working as a principals and vise principals who worked in 2005 in Düzce elementary schools and high schools were surveyed in line with this aim. Mann-Whitney U-test, Kruskal Wallis test and ANOVA were used in order to find out groups that differ from others. It has been found that school administrators’ emotional intelligence scores differ meaningfully in terms of administrators’ branch and being elementary school administrator or high school.

  18. Virtual Reality and Public Administration

    Directory of Open Access Journals (Sweden)

    István TÓZSA

    2013-02-01

    Full Text Available This study serves as an introduction to how virtual reality systems could be applied in public administration and what research tasks would be necessary to accomplish a project. E-government solutions began to emerge in public administration approximately a decade ago all over the developed world. Administration service facilities via the Internet did not attract many customers, because of the digital divide. E-government solutions were extended to mobile devices as well, but the expected breakthrough of usage has not ensued. The virtual reality form of public administration services recommended in this study has the most attractive outlay and the simplest navigation tools if compared to ‘traditional’ Internet based e-government. Thus, in accordance with the worldwide amazingly quick spread of the virtual reality systems of Second Life and 3 D types of entertainment, virtual reality applications in public administration could rely on a wide range of acceptance as well.

  19. Research on the Application of Big Data in Tourism Administration%大数据在旅游管理中的应用探讨研究

    Institute of Scientific and Technical Information of China (English)

    刘志霞

    2016-01-01

    旅游管理的核心对象———旅游服务供应链,以旅游产品为主线,由基础设施生产商、提供食住行游购娱的旅游供应商、旅游中介商、旅游者以及旅游管理部门组成。通过实现旅游供应过程中服务流、信息流、价值流的“三流”合一,大数据正深刻影响着旅游服务供应链上的各方,旅游业发展也因此开始真正迈向“智慧旅游”。%The service supply chain of tourism, as the core of the tourism administration, takes tourism products as its major target which consisted of the infrastructure manufacturers, the suppliers that provides food, accommodation, transportation, shopping and entertainment services, the travel agents, the tourists and related administrative departments. Through combing the flows of service & information as well as the value stream in the tourism services providing processes, the big data has been profoundly affecting each party in the supply chain, and the tourism industry is stepping into the era of "Intelligent Travel". Combining the service supply chain of tourism and the key technical characteristics of the big data, the practical adoption of Big Data in tourism service supply chain management will be discussed from the macro and micro dimensions, and some key technologies involved also are analyzed. Finally, the outlook for the next stage of tourism administrative development in the big data environment will be put forward.

  20. The Difficulties of Female Primary School Administrators in the Administration Process and Solution Suggestions

    Science.gov (United States)

    Kosar, Didem; Altunay, Esen; Yalçinkaya, Mu¨nevver

    2014-01-01

    The aim of this research is to determine the administration experiences of female administrators, find out the troubles they have had during their administration process, and suggest some solutions according to these experiences. The qualitative method was used in this research and data was collected via the semi-structured interview form…