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Sample records for adjusted d-dimer cut-off

  1. Elevated d-dimer cut-off values for computed tomography pulmonary angiography—d-dimer correlates with location of embolism

    Science.gov (United States)

    Kubak, Mateuzs Piotr; Borthne, Arne; Ruud, Espen Asak; Ashraf, Haseem

    2016-01-01

    Background Acute pulmonary embolism (APE) is a potentially fatal condition, and making a timely diagnosis can be challenging. Computed tomography pulmonary angiography (CTPA) has become the modality of choice, and this contributes to the increasing load on emergency room CT scanners. Our purpose was to investigate whether an elevated d-dimer cut-off could reduce the demand for CTPA while maintaining a high sensitivity and negative predictive value (NPV). Methods We retrospectively reviewed all patients referred for CTPA with suspicion of APE in 2012, and collected d-dimer values and CTPA results. We investigated the diagnostic performance of d-dimer using a 0.5 mg/L cut-off and an age adjusted cut-off. We also evaluated a new and elevated cut-off. Cases were categorized according to their CTPA result into: no embolism, peripheral embolism, lobar embolism and central embolism. Finally we investigated a possible correlation between d-dimer values and location of embolism. Results We included 1,051 CTPAs, from which 216 (21%) showed pulmonary embolism. There were concomitant d-dimer analyses in 822 CTPA examinations. The current 0.5 mg/L cut-off achieved a sensitivity and NPV of 99%. The age-adjusted cut-off achieved a sensitivity and NPV of 98%, and our suggested cut-off of 0.9 mg/L achieved a sensitivity and NPV of 97%. Conclusions We conclude that the elevated d-dimer cut-off of 0.9 mg/L achieved a high sensitivity and NPV, while reducing the number of CTPA by 27%. The correlation between d-dimer values and location of embolisms supports the suggestion of an elevated d-dimer value. PMID:27386486

  2. Using an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded

    NARCIS (Netherlands)

    Douma, Renée A.; Tan, Melanie; Schutgens, Roger E.G.; Bates, Shannon M.; Perrier, Arnaud; Legnani, Cristina; Biesma, Douwe H.; Ginsberg, Jeffrey S.; Bounameaux, Henri; Palareti, Gualtiero; Carrier, Marc; Mol, Gerben C.; Le Gal, Grégoire; Kamphuisen, Pieter W.; Righini, Marc

    2012-01-01

    Background D-dimer testing to rule out deep vein thrombosis is less useful in older patients because of a lower specificity. An age-adjusted D-dimer cut-off value increased the proportion of older patients (>50 years) in whom pulmonary embolism could be excluded. We retrospectively validated the eff

  3. Age-dependent D-dimer cut-off to avoid unnecessary CT-exams for ruling-out pulmonary embolism; Altersangepasste Anhebung des D-Dimer-Grenzwertes zur Vermeidung unnoetiger CT-Untersuchungen bei Verdacht auf Lungenarterienembolie

    Energy Technology Data Exchange (ETDEWEB)

    Altmann, M.M.; Hoehne, M.; Herold, T. [HELIOS Klinikum Berlin-Buch (Germany). Radiology; Wrede, C.E. [HELIOS Klinikum Berlin-Buch (Germany). Emergency Department; Peetz, D. [HELIOS Klinikum Berlin-Buch (Germany). Laboratory Medicine; Stroszczynski, C. [University Medical Center, Radiology, Regensburg (Germany)

    2015-09-15

    To evaluate the effect of an age-dependent D-Dimer cut-off in patients who underwent a computed tomography pulmonary angiogram (CTPA) for suspected pulmonary embolism (PE). Retrospective application of an age-dependent D-dimer cut-off (age/100 in patients aged over 50) in 530 consecutive patients, both in- and outpatients, aged over 18, who underwent CTPA for suspected PE according to the guidelines. The application of an age-dependent D-dimer cut-off showed a now negative test-result in 17 of 530 patients (3.2 %). The proportion was 4.1 % (17 of 418) in patients aged over 50. None of these 17 cases was diagnosed with PE in CTPA, the false-negative rate was 0 %. The effect could be seen in outpatients (14 of 377 [3.7 %]) as well as in inpatients(3 of 153 [2.0 %]) with no statistically significant difference (p > 0.05). The application of an age-dependent D-dimer cut-off as part of the guideline-based algorithm for suspected PE reduced the number of necessary CTPA in outpatients as well as in inpatients.

  4. How to use D-dimer in acute cardiovascular care

    DEFF Research Database (Denmark)

    Giannitsis, Evangelos; Mair, Johannes; Christersson, Christina

    2015-01-01

    D-dimer testing is important to aid in the exclusion of venous thromboembolic events (VTEs), including deep venous thrombosis and pulmonary embolism, and it may be used to evaluate suspected aortic dissection. D-dimer is produced upon activation of the coagulation system with the generation and s...... testing. For the exclusion of pulmonary embolism/deep vein thrombosis, age-adjusted cut-offs are recommend. Clinicians must be aware of the validated use of their hospital's D-dimer assay to avoid inappropriate use of this biomarker in routine care....

  5. Phase- and size-adjusted CT cut-off for differentiating neoplastic lesions from normal colon in contrast-enhanced CT colonography

    Energy Technology Data Exchange (ETDEWEB)

    Luboldt, W. [University Hospital Frankfurt, Department of Radiology, Frankfurt (Germany); Multiorgan Screening Foundation, Frankfurt (Germany); University Hospital Essen, Clinic of Angiology, Essen (Germany); Kroll, M.; Wetter, A.; Vogl, T.J. [University Hospital Frankfurt, Department of Radiology, Frankfurt (Germany); Toussaint, T.L. [Multiorgan Screening Foundation, Frankfurt (Germany); Hoepffner, N. [University Hospital Frankfurt, Department of Internal Medicine, Frankfurt (Germany); Holzer, K. [University Hospital Frankfurt, Department of Visceral and Vascular Surgery, Frankfurt (Germany); Kluge, A. [Kerckhoff Heart Center, Department of Radiology, Bad Nauheim (Germany)

    2004-12-01

    A computed tomography (CT) cut-off for differentiating neoplastic lesions (polyps/carcinoma) from normal colon in contrast-enhanced CT colonography (CTC) relating to the contrast phase and lesion size is determined. CT values of 64 colonic lesions (27 polyps <10 mm, 13 polyps {>=}10 mm, 24 carcinomas) were determined by region-of-interest (ROI) measurements in 38 patients who underwent contrast-enhanced CTC. In addition, the height (H) of the colonic lesions was measured in CT. CT values were also measured in the aorta (A), superior mesenteric vein (V) and colonic wall. The contrast phase was defined by xA + (1 - x)V using x as a weighting factor for describing the different contrast phases ranging from the pure arterial phase (x=1) over the intermediate phases (x=0.9-0.1) to the pure venous phase (x=0). The CT values of the lesions were correlated with their height (H), the different phases (xA + (1 - x)V) and the ratio [xA + (1 - x)V]/H. The CT cut-off was linearly adjusted to the imaged contrast phase and height of the lesion by the line y = m[xA + (1 - x)V]/H + y{sub 0}. The slope m was determined by linear regression in the correlation (lesion {proportional_to}[xA + (1 - x)V]//H) and the Y-intercept y{sub 0} by the minimal shift of the line needed to maximize the accuracy of separating the colonic wall from the lesions. The CT value of the lesions correlated best with the intermediate phase: 0.4A+ 0.6V(r=0.8 for polyps {>=}10 mm, r=0.6 for carcinomas, r=0.4 for polyps <10 mm). The accuracy in the differentiation between lesions and normal colonic wall increased with the height implemented as divisor, reached 91% and was obtained by the dynamic cut-off described by the formula: cut-off(A,V,H) = 1.1[0.4A + 0.6V]/H + 69.8. The CT value of colonic polyps or carcinomas can be increased extrinsically by scanning in the phase in which 0.4A + 0.6V reaches its maximum. Differentiating lesions from normal colon based on CT values is possible in contrast-enhanced CTC and

  6. The original and simplified Wells rules and age-adjusted D-dimer testing to rule out pulmonary embolism: an individual patient data meta-analysis.

    Science.gov (United States)

    van Es, N; Kraaijpoel, N; Klok, F A; Huisman, M V; Den Exter, P L; Mos, I C M; Galipienzo, J; Büller, H R; Bossuyt, P M

    2017-04-01

    Essentials Evidence for the simplified Wells rule in ruling out acute pulmonary embolism (PE) is scarce. This was a post-hoc analysis on data from 6 studies comprising 7268 patients with suspected PE. The simplified Wells rule combined with age-adjusted D-dimer testing may safely rule out PE. Given its ease of use, the simplified Wells rule is to be preferred over the original Wells rule.

  7. Serum Potassium Levels Inversely Correlate with D-Dimer In Patients with Acute-Onset Atrial Fibrillation

    Energy Technology Data Exchange (ETDEWEB)

    Cervellin, Gianfranco, E-mail: gcervellin@ao.pr.it; Bonfanti, Laura; Picanza, Alessandra; Lippi, Giuseppe [1Academic Hospital of Parma (Italy)

    2015-03-15

    D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared to subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared with subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. The aim of this study was to investigate correlations between D-dimer and serum potassium in acute-onset AF (AAF). To investigate the potential correlation between the values of serum potassium and D-dimer in patients with AAF, we retrospectively reviewed clinical and laboratory data of all emergency department visits for AAF in 2013. Among 271 consecutive AAF patients with D-dimer assessments, those with hypokalemia (n = 98) had significantly higher D-dimer values than normokalemic patients (139 versus 114 ng/mL, p = 0.004). The rate of patients with D-dimer values exceeding the diagnostic cut-off was higher in the group of patients with hypokalemia than in those with normal serum potassium (26.5% versus 16.2%; p = 0.029). An inverse and highly significant correlation was found between serum potassium and D-dimer (r = −0.21; p < 0.001), even after adjustments for age and sex (beta coefficient −94.8; p = 0.001). The relative risk for a positive D-dimer value attributed to hypokalemia was 1.64 (95% CI, 1.02 to 2.63; p = 0.040). The correlation remained statistically significant in patients free from antihypertensive drugs (r = −0.25; p = 0.018), but not in those taking angiotensin-receptor blockers, angiotensin-converting enzyme inhibitors, or diuretics. The inverse correlation between values of potassium and D-dimer in patients with AAF provides important and complementary information about the thromboembolic risk of these patients.

  8. 热阻可调式断桥复合保温砌块的研制%Development of a bridge-cut-off composite insulation block with the adjustable thermal resistance feature

    Institute of Scientific and Technical Information of China (English)

    胡永权; 任增茂; 罗天祥; 陈延军

    2015-01-01

    This paper introduces a bridge-cut-off composite insulation block with the adjustable thermal resistance feature,which structure is constituted by a new force block and insulating material.Regulating the proportion size of the insulation material and air interlayer on the basis of constant force main structure,the block can meet the demand of the wall thermal performance in different climatic regions with an economical way, and the performance price ratio of the block enhances at the same time.The block can use many kinds of waste in its production,e.g.,fly ash,construction waste.It has many advantages,such as environmental protection,energy conservation,fire preventing and so on,which can be generalized in nationwide.%介绍了一种热阻可调式断桥复合保温砌块,该砌块采用新型受力块体与绝热材料复合构造,在受力主体结构不变的基础上,可以通过调节绝热材料和空气间层配合尺寸,以最经济的方式满足不同气候环境区域对墙体热工性能的要求,增强了复合保温砌块节能性价比。该砌块在生产过程中可以利用粉煤灰、建筑垃圾等多种废弃物,具有经济、环保、节能和防火性能好等特点,适合在全国范围内推广应用。

  9. From Dimensional to Cut-Off Regularization

    CERN Document Server

    Dillig, M

    2006-01-01

    We extent the standard approach of dimensional regularization of Feynman diagrams: we replace the transition to lower dimensions by a 'natural' cut-off regulator. Introducing an external regulator of mass Lambda^(2e), we regain in the limit e -> 0 and e > 0 the results of dimensional and cut-off regularization, respectively. We demonstrate the versatility and adequacy of the different regularization schemes for practical examples (such as non covariant regularization, the axial anomaly or regularization in effective field theories).

  10. Symptom-dependent cut-offs of urine metanephrines improve diagnostic accuracy for detecting pheochromocytomas in two separate cohorts, compared to symptom-independent cut-offs.

    Science.gov (United States)

    Cho, Yoon Young; Song, Kee-Ho; Kim, Young Nam; Ahn, Seong Hee; Kim, Hyeonmok; Park, Sooyoun; Suh, Sunghwan; Kim, Beom-Jun; Lee, Soo-Youn; Chun, Sail; Koh, Jung-Min; Lee, Seung Hun; Kim, Jae Hyeon

    2016-10-01

    The development of advanced imaging techniques has increased the detection of subclinical pheochromocytomas. Because of the substantial proportions of subclinical pheochromocytomas, measurement of urine metanephrine concentrations is crucial due to detect or exclude pheochromocytoma. Although urine metanephrines are elevated in symptomatic subjects, diagnostic cut-offs according to the presence of adrenergic symptoms have not been studied. Pheochromocytomas patients who underwent adrenalectomy at Samsung Medical Center and a control group were compared to determine cut-off concentrations of urine metanephrines. An independent population was analyzed for urine metanephrines with different kits to validate the improvement in diagnostic accuracy using adjusted cut-offs. Symptom-dependent cut-offs of urine metanephrines were higher for symptomatic patients (307 μg/day in males, 235 μg/day in females for urine metanephrine, and 1,045 μg/day in males and 457 μg/day in females for urine normetanephrine) than for asymptomatic patients (206 μg/day in males, 199 μg/day in females for urine metanephrine, and 489 μg/day in males and 442 μg/day in females for urine normetanephrine). Symptom-dependent cut-offs of urine metanephrines improved a specificity from 92.7 % to 96.3 % and a high sensitivity of 97.8 % was maintained. Using the Symptom-dependent cut-offs raised diagnostic accuracy by 5.5 % (p <0.001). Similar trend was also observed in an independent population using different hormone kits. Using symptom-dependent cut-offs of urine metanephrines in symptomatic patients for pheochromocytomas resulted in a significant improvement in diagnostic accuracy in two separate cohorts.

  11. Fiber optic D dimer biosensor

    Science.gov (United States)

    Glass, Robert S.; Grant, Sheila A.

    1999-01-01

    A fiber optic sensor for D dimer (a fibrinolytic product) can be used in vivo (e.g., in catheter-based procedures) for the diagnosis and treatment of stroke-related conditions in humans. Stroke is the third leading cause of death in the United States. It has been estimated that strokes and stroke-related disorders cost Americans between $15-30 billion annually. Relatively recently, new medical procedures have been developed for the treatment of stroke. These endovascular procedures rely upon the use of microcatheters. These procedures could be facilitated with this sensor for D dimer integrated with a microcatheter for the diagnosis of clot type, and as an indicator of the effectiveness, or end-point of thrombolytic therapy.

  12. HIGH D-DIMER LEVELS PREDICT A POOR OUTCOME IN PATIENTS WITH SEVERE TRAUMA, EVEN WITH HIGH FIBRINOGEN LEVELS ON ARRIVAL: A MULTICENTER RETROSPECTIVE STUDY.

    Science.gov (United States)

    Hayakawa, Mineji; Maekawa, Kunihiko; Kushimoto, Shigeki; Kato, Hiroshi; Sasaki, Junichi; Ogura, Hiroshi; Matauoka, Tetsuya; Uejima, Toshifumi; Morimura, Naoto; Ishikura, Hiroyasu; Hagiwara, Akiyoshi; Takeda, Munekazu; Kaneko, Naoyuki; Saitoh, Daizoh; Kudo, Daisuke; Kanemura, Takashi; Shibusawa, Takayuki; Furugori, Shintaro; Nakamura, Yoshihiko; Shiraishi, Atsushi; Murata, Kiyoshi; Mayama, Gou; Yaguchi, Arino; Kim, Shiei; Takasu, Osamu; Nishiyama, Kazutaka

    2016-03-01

    Elevated D-dimer level in trauma patients is associated with tissue damage severity and is an indicator of hyperfibrinolysis during the early phase of trauma. To investigate the interacting effects of fibrinogen and D-dimer levels on arrival at the emergency department for massive transfusion and mortality in severe trauma patients in a multicenter retrospective study. This study included 519 adult trauma patients with an injury severity score ≥16. Patients with ≥10 units of red cell concentrate transfusion and/or death during the first 24 h were classified as having a poor outcome. Receiver operating characteristic curve analysis for predicting poor outcome showed the optimal cut-off fibrinogen and D-dimer values to be 190 mg/dL and 38 mg/L, respectively. On the basis of these values, patients were divided into four groups: low D-dimer (high fibrinogen (>190 mg/dL), low D-dimer (low fibrinogen (≤190 mg/dL), high D-dimer (≥38 mg/L)/high fibrinogen (>190 mg/dL), and high D-dimer (≥38 mg/L)/low fibrinogen (≤190 mg/dL). The survival rate was lower in the high D-dimer/low fibrinogen group than in the other groups. Moreover, the survival rate was lower in the high D-dimer/high fibrinogen group than in the low D-dimer/high fibrinogen and low D-dimer/low fibrinogen groups. High D-dimer level on arrival is a strong predictor of early death or requirement for massive transfusion in severe trauma patients, even with high fibrinogen levels.

  13. Necessity Analysis of Cut-off Valve for Vehicle Altitude Adjusting System of a Wheel Vehicle%某轮式车辆车姿调节系统截止阀必要性分析

    Institute of Scientific and Technical Information of China (English)

    侯友山; 孙晓光; 陈宇; 曹宇

    2015-01-01

    针对某轮式车辆车姿调节系统油气弹簧充放油口处的截止阀是否有必要的问题,建立了油气弹簧-截止阀-液压管路-液压锁局部系统的数学模型,并借助Simulink建立了仿真模型,重点就活塞杆不同运动速度下、液压管路内压力脉动情况进行仿真分析。仿真结果表明:活塞杆瞬间运动速度提高将会产生瞬间液压冲击,导致液压管路内有剧烈的压力脉动且脉动峰值较大,该压力脉动峰值会影响油气弹簧的性能及造成软管的爆裂损坏。因此车姿调节系统有必要保留此截止阀。%Aiming at the necessity of cut⁃off valve in vehicle altitude adjusting system of a wheel vehicle, the mathematical model of oil and gas spring⁃cutoff valve⁃hydraulic line⁃hydraulic lock and the simulation model were established, mainly analyzing the pressure pulsation in the pipeline under different velocity of the piston rod. The simulation results show that the instantaneous velocity of the pis⁃ton rod will produce instantaneous hydraulic impact and cause severe pressure pulsation in the hydraulic pipeline, the pressure fluctua⁃tion peak will affect the performance of the oil⁃gas spring and cause hose bursting damage. So it is necessary to keep the cut⁃off valve.

  14. Sensory cut-off point obtained from survival analysis statistics

    OpenAIRE

    Garitta, Lorena; Langohr, Klaus; Gómez Melis, Guadalupe; Hough, Guillermo; Beeren, Cindy

    2015-01-01

    In the present work we applied interval-censored survival analysis techniques to estimate sensory cut-off points based on consumer’s decision to accept or reject food products taking into account the inherent variability in sensory measurements. We compared the values obtained using this survival analysis methodology with those obtained by applying a previous regression based method. Cut-off point (COP) estimations were made for acid flavor in yogurt, strawberry flavor in a strawberry flav...

  15. Cut-off Grade Optimization for Maximizing the Output Rate

    Directory of Open Access Journals (Sweden)

    A. Khodayari

    2012-12-01

    Full Text Available In the open-pit mining, one of the first decisions that must be made in production planning stage, after completing the design of final pit limits, is determining of the processing plant cut-off grade. Since this grade has an essential effect on operations, choosing the optimum cut-off grade is of considerable importance. Different goals may be used for determining optimum cut-off grade. One of these goals may be maximizing the output rate (amount of product per year, which is very important, especially from marketing and market share points of view. Objective of this research is determining the optimum cut-off grade of processing plant in order to maximize output rate. For performing this optimization, an Operations Research (OR model has been developed. The object function of this model is output rate that must be maximized. This model has two operational constraints namely mining and processing restrictions. For solving the model a heuristic method has been developed. Results of research show that the optimum cut-off grade for satisfying pre-stated goal is the balancing grade of mining and processing operations, and maximum production rate is a function of the maximum capacity of processing plant and average grade of ore that according to the above optimum cut-off grade must be sent to the plant.

  16. Adapting the D-dimer cutoff for thrombosis detection in elderly outpatients.

    Science.gov (United States)

    Andro, Marion; Righini, Marc; Le Gal, Grégoire

    2013-06-01

    D-dimer measurement is an important step in diagnostic strategies for venous thromboembolism. It allows the safe ruling out of the diagnosis with no need for imaging tests in approximately 30% of outpatients. However, the usefulness of d-dimer is limited in elderly patients; the likelihood of a negative d-dimer strongly decreases with age, making physicians reluctant to order the test. Several attempts to improve the performance of D-dimer in elderly patients have been pursued. Recently, an age-adjusted cutoff was derived; the optimal cutoff value (in µg/l) appears to be equal to the patient's age (in years) multiplied by ten in patients over 50 years of age with a low pretest clinical risk of venous thromboembolism. This age-adjusted cutoff value has been extensively and externally validated in retrospective studies that included mostly outpatients with suspected deep vein thrombosis or pulmonary embolism and used various quantitative D-dimer assays. All available studies confirmed the increased usefulness and similar safety of the age-adjusted cutoff compared with the conventional cutoff, the most important benefit being obtained in elderly patients. However, before any recommendation for clinical practice can be made, a prospective diagnostic management outcome study is lacking, in which all low clinical risk patients with D-dimer levels below their age-adjusted cutoff would be left untreated with no further diagnostic testing.

  17. Designing the sound of a cut-off drum

    CERN Document Server

    Martinetti, Pierre

    2015-01-01

    The spectral action in noncommutative geometry naturally implements an ultraviolet cut-off, by counting the eigenvalues of a (generalized) Dirac operator lower than an energy of unification. Inverting the well known question "how to hear the shape of a drum ?", we ask what drum can be designed by hearing the truncated music of the spectral action ? This makes sense because the same Dirac operator also determines the metric, via Connes distance. The latter thus offers an original way to implement the high-momentum cut-off of the spectral action as a short distance cut-off on space. This is a non-technical presentation of the results of http://arxiv.org/abs/1305.2605

  18. A PROBLEM OF CUTTING OFF THE LAMINATED SEMIS TYPE PLATE

    Directory of Open Access Journals (Sweden)

    Florin Ciofu

    2012-11-01

    Full Text Available A problem often coped on many domains such as wood manufacturing, glass, plastics and metallic platework industry, is the shaping or cutting off a big plate in many pieces. With this purpose there are algorithms of optimizing for positioning the parts following to be cut off from a row plate. From mathematical point of view, in positioning the parts on a raw plate the number of solutions increase four times evrey time a new part is added, and in case of finding the best solution for about few hundreds of pieces or parts would require years of processing on the most performant computers nowadays – for an analogy remember the famous story with the rice beads which the King had to pay to the master teaching him the chess: twice more for each square of the chessboard; for the total quantity assessment, King ascertained that the crops in his whole life wouldn’t have been enough.

  19. Hemoglobin cut-off values in healthy Turkish infants

    Institute of Scientific and Technical Information of China (English)

    Ahmet Arvas; Emel Gür; DurmuşDoğan

    2014-01-01

    Background: Anemia is a widespread public health problem associated with an increased risk of morbidity and mortality. This study was undertaken to determine the cut-off value of hemoglobin for infant anemia. Methods: A cross-sectional retrospective study was carried out at well-baby clinics of a tertiary care hospital. A total of 1484 healthy infants aged between 4 to 24 months were included in the study. The relationship of hemoglobin (Hb) levels with mother age, birth weight, weight gain rate, feeding, and gender was evaluated. Results: The Hb levels were assessed in four age groups (4 months, 6 months, 9-12 months, and 15-24 months) and the cut-off values of Hb were determined. Hb cut-off values (5th percentile for age) were detected as 97 g/L and 93 g/L at 4 months and 6 months, respectively. In older infants, the 5th percentile was 90.5 g/L and 93.4 g/L at 9-12 months and 15-24 months, respectively. The two values were lower than the World Health Organization criteria for anemia, which could partly due to the lack of information on iron status in our population. However, this difference highlights the need for further studies on normal Hb levels in healthy infants in developing countries. Hb levels of females were higher in all age groups; however, a statistically significant difference was found in gender in only 6 month-old infants. No statistically significant difference was found among Hb levels, mother's age, birth weight, weight gain rate, and nutritional status. Conclusion: Hb cut-off values in infants should be re-evaluated and be compatible with growth and development of children in that community.

  20. Large D-Dimer Fluctuation in Normal Pregnancy

    DEFF Research Database (Denmark)

    Hedengran, Katrine K; Andersen, Malene R; Stender, Steen

    2016-01-01

    pregnancies were recruited. D-dimer was repeatedly measured during pregnancy, at active labor, and on the first and second postpartum days. Percentiles for each gestational week were calculated. Each individual D-dimer was normalized by transformation into percentiles for the relevant gestational age......Introduction. D-dimer levels increase throughout pregnancy, hampering the usefulness of the conventional threshold for dismissing thromboembolism. This study investigates the biological fluctuation of D-dimer in normal pregnancy. Methods. A total of 801 healthy women with expected normal...... normal pregnancy, repeated D-dimer measurements are of no clinical use in the evaluation of thromboembolic events during pregnancy....

  1. Energetics of southeastern Pacific cut-off lows

    Science.gov (United States)

    Gan, Manoel Alonso; Piva, Everson Dal

    2016-06-01

    The existence of cut-off lows (COLs) over South Pacific and South America is often associated with adverse weather events such as intense precipitation over the central region of South America, frost episodes in southern Brazil and the development of Andes lee cyclones and intense cyclones over the southern coast of Brazil. Despite this importance, the formation and maintenance mechanisms of the COLs are not well understood. To detail the significant variability in terms of the eddy kinetic energy equation for fifty cases of COLs that formed over the southeastern Pacific Ocean is the aim of this study. Only the cases of COLs that formed over the ocean and remained there during most of their life were chosen. The main terms of the equation [ageostrophic flux convergence (AFC), baroclinic conversion (BRC) and barotropic conversion (BRT)] were calculated using the 6-hourly gridded data from the National Centers for Environmental Prediction/Department of Energy reanalysis. The formation mechanism of the COLs was associated with BRC and AFC. During the midlife period, the BRC term converted eddy kinetic energy to eddy potential energy and the AFC had a positive contribution until 6 h after the midlife point. In the dissipation phase, the BRC term remained positive and AFC became negative. The BRT extracted kinetic energy from the COL during the entire life cycle. The AFC term was the most important in all phases of the cut-off lifetime, and it was the responsible for extending the cut-off lifetime while the others terms were negatives.

  2. Norms for the mini-mental state examination: adjustment of the cut-off point in population-based studies (evidences from the Bambuí health aging study Normas para o uso do mini-exame do estado mental: adequação do ponto de corte em estudos populacionais (evidências do Projeto Bambuí

    Directory of Open Access Journals (Sweden)

    Érico Castro-Costa

    2008-09-01

    Full Text Available OBJECTIVE: To estimate the prevalence of cognitive impairment in an elderly population-based cohort, using several Mini-Mental State Examination (MMSE cut-off points recommended by Brazilian authors and to examine the percentile distribution of MMSE scores in the study population. METHOD: A total of 1558 subjects aged >60 years (89.4% of the total, living in the city of Bambuí, MG, completed the MMSE and were included in the present study. RESULTS: The estimated prevalences of cognitive impairment varied from 13.2% to 27.0% depending on the cut-off point and agreement varied widely between them (kappa range: 0.38 to 0.88. Cut-off point 13/14 corresponded to the 5th percentile and 21/22 corresponded to the lower quartile of the MMSE score distribution. CONCLUSION: In the absence of comparable cut-off points, percentile distributions are more adequate for population-based studies of elderly with low schooling level.OBJETIVO: Estimar a prevalência de déficit cognitivo em uma base populacional de idosos, utilizando-se os diferentes pontos de corte do Mini-Exame do Estado Mental (MEEM recomendados por autores brasileiros e verificar a distribuição em percentis da pontuação do MEEM na população estudada. MÉTODO: Participaram do estudo 1558 (89,4% do total indivíduos com idade >60 anos residentes na cidade de Bambuí, MG, que foram submetidos ao MEEM. RESULTADOS: A prevalência estimada de déficit cognitivo variou de 13,2% a 27,0%, dependendo do ponto de corte utilizado, observando-se grande variação na sua concordância (índices de kappa entre 0,38 e 0,88. O ponto de corte de 13/14 correspondeu ao 5º percentil e o de 21/22, ao quartil inferior da distribuição dos escores do MEEM. CONCLUSÃO: Na ausência de pontos de corte comparáveis, a distribuição em percentis é mais adequada para estudos de base populacional de idosos com baixa escolaridade.

  3. Permeability porosity relationships (K, Phi cut-off)

    Energy Technology Data Exchange (ETDEWEB)

    Djettou, F.; Reda, H. [Sonatrach, Algiers (Algeria)

    1995-08-01

    Several reservoirs of Lower Devonian in Ghadames basin present porosities greater than 10 Pu, but during the test they are rather impermeable. It seems that this phenomena extends to BERKINE and Rhourd Messaoud areas. This seriously affect the estimation of recovery reserves. The best we can do is to study and try to understand reservoir problems. The method we choose is based on statistical analysis of test results and their comparison with core and log measurements. It concerns mainly cummulative curves of productive and non-productive tests (dry test). This involves about 20 wells where are can define: Siegenian with: Fine grained in BBK and ROM Coarse grained toward BRN - Emsian is rather homogeneous in the region. The sand cut-off porosity is greater than 11 Pu. However the reservoir can`t produce itself then we can not take account in reserve estimation. In conclusion, a sandy reservoir of Lower Devonian in Ghadames basin may be very porous (11-12%) and impermeable while in the other cases reservoirs can produce with porosity of 7 or 8 Po. However a HC definition based on cut-off porosity in Ghadames basin should be done before net pay an recovery reserves estimation.

  4. Genetic predictors of fibrin D-dimer levels in healthy adults

    Science.gov (United States)

    Smith, Nicholas L.; Huffman, Jennifer E.; Strachan, David P.; Huang, Jie; Dehghan, Abbas; Trompet, Stella; Lopez, Lorna M.; Shin, So-Youn; Baumert, Jens; Vitart, Veronique; Bis, Joshua C.; Wild, Sarah H.; Rumley, Ann; Yang, Qiong; Uitterlinden, Andre G; Stott, David. J.; Davies, Gail; Carter, Angela M.; Thorand, Barbara; Polašek, Ozren; McKnight, Barbara; Campbell, Harry; Rudnicka, Alicja R.; Chen, Ming-Huei; Buckley, Brendan M.; Harris, Sarah E.; Williams, Frances M. K.; Peters, Annette; Pulanic, Drazen; Lumley, Thomas; de Craen, Anton J.M.; Liewald, David C.; Gieger, Christian; Campbell, Susan; Ford, Ian; Gow, Alan J.; Luciano, Michelle; Porteous, David J.; Guo, Xiuqing; Sattar, Naveed; Tenesa, Albert; Cushman, Mary; Slagboom, P. Eline; Visscher, Peter M.; Spector, Tim D.; Illig, Thomas; Rudan, Igor; Bovill, Edwin G.; Wright, Alan F.; McArdle, Wendy L.; Tofler, Geoffrey; Hofman, Albert; Westendorp, Rudi G.J.; Starr, John M.; Grant, Peter J.; Karakas, Mahir; Hastie, Nicholas D.; Psaty, Bruce M.; Wilson, James F.; Lowe, Gordon D. O.; O’Donnell, Christopher J; Witteman, Jacqueline CM; Jukema, J. Wouter; Deary, Ian J.; Soranzo, Nicole; Koenig, Wolfgang; Hayward, Caroline

    2011-01-01

    Background Fibrin fragment D-dimer is one of several peptides produced when cross-linked fibrin is degraded by plasmin, and is the most widely-used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search. Methods and Results A genome-wide investigation of the genomic correlates of plasma D-dimer levels was conducted among 21,052 European-ancestry adults. Plasma levels of D-dimer were measured independently in each of 13 cohorts. Each study analyzed the association between ~2.6 million genotyped and imputed variants across the 22 autosomal chromosomes and natural-log transformed D-dimer levels using linear regression in additive genetic models adjusted for age and sex. Among all variants, 74 exceeded the genome-wide significance threshold and marked 3 regions. At 1p22, rs12029080 (p-value 6.4×10−52) was 46.0 kb upstream from F3, coagulation factor III (tissue factor). At 1q24, rs6687813 (p-value 2.4×10−14) was 79.7 kb downstream of F5, coagulation factor V. At 4q32, rs13109457 (p-value 2.9×10−18) was located between 2 fibrinogen genes: 10.4 kb downstream from FGG and 3.0 kb upstream from FGA. Variants were associated with a 0.099, 0.096, and 0.061 unit difference, respectively, in natural-log transformed D-dimer and together accounted for 1.8% of the total variance. When adjusted for non-synonymous substitutions in F5 and FGA loci known to be associated with D-dimer levels, there was no evidence of an additional association at either locus. Conclusions Three genes were associated with fibrin D-dimer levels, of which the F3 association was the strongest and has not been previously reported. PMID:21502573

  5. Physical and cut-off effects of heavy sea quarks

    CERN Document Server

    Knechtli, Francesco; Bruno, Mattia; Finkenrath, Jacob; Leder, Björn; Marinkovic, Marina; Sommer, Rainer

    2014-01-01

    We simulate a theory with two dynamical O($a$) improved Wilson quarks whose mass $M$ ranges from a factor eight up to a factor two below the charm quark mass and at three values of the lattice spacing ranging from 0.066 to 0.034 fm. This theory is a prototype to study the decoupling of heavy quarks. We measure the mass and cut-off dependence of ratios of gluonic observables defined from the Wilson flow or the static potential. The size of the 1/$M$ corrections can be determined and disentangled from the lattice artifacts. The difference with the pure gauge theory is at the percent level when two quarks with a mass of the charm quark are present.

  6. General cutting-off die for trapezoidal sheet%梯形料片通用切断模设计

    Institute of Scientific and Technical Information of China (English)

    徐柏鸿

    2013-01-01

      介绍了一种可快速调整刀口间隙、切口位置、角度的梯形料通用切断模,配套自动矫平送料机,实现了切断模的自动化生产,提高了生产效率,降低了生产成本,取得了较好的经济效益。%A general cutting-off die being able to quickly adjust the trapezoidal sheet was presented which was used in the automatic leveling feeder. Through implementing the auto⁃matic production using cutting-off die, the production efficiency was improved and its cost was reduced.

  7. Explaining the use of attribute cut-off values in decision making by means of involvement

    DEFF Research Database (Denmark)

    Peschel, Anne O.; Grebitus, Carola; Colson, Gregory

    2016-01-01

    evidence on consumers’ heterogeneous use of attribute cut-offs with a unique focus on the relationship with consumer involvement, a key component in consumer choice theory. Behavioral data from an online choice experiment on beef steak employing shelf simulations are combined with questions defining...... respondents’ attribute cut-off values and their validated Personal Involvement Inventory (PII). Evidence from the analysis indicates that consumers who are highly involved are more likely to exhibit attribute cut-off values and are less likely to violate their cut-off values. Further investigation using...... a latent class model identifies several key consumer segments (e.g., a price sensitive group) based on their choice behavior and reveals that the relationship between involvement, cut-off use and cut-off violations is not uniform across consumer segments....

  8. Transferring Cut-off Values between Assays for Cerebrospinal Fluid Alzheimer's Disease Biomarkers

    OpenAIRE

    Garcia Barrado, Leandro; Coart, Els; Vanderstichele, Hugo M. J.; Burzykowski, Tomasz

    2015-01-01

    Current technologies quantifying cerebrospinal fluid biomarkers to identify subjects with Alzheimer's disease pathology report different concentrations in function of technology and suffer from between-laboratory variability. Hence, lab- and technology-specific cut-off values are required. It is common practice to establish cut-off values on small datasets and, in the absence of well-characterized samples, to transfer the cut-offs to another assay format using 'side-by-side' testing of sample...

  9. Emission Enhancement in a Plasmonic Waveguide at Cut-Off

    Directory of Open Access Journals (Sweden)

    Andrea Alù

    2011-01-01

    Full Text Available Enhancement of molecular emission is usually obtained by coupling small optical emitters with external resonant structures and systems, as first established by Purcell several decades ago, and verified in several recent investigations using molecules or quantum dots coupled with plasmonic nanoantennas. Here we theoretically investigate in detail a different mechanism for emission enhancement, based on our recent idea of a plasmonic nanolauncher [Phys. Rev. Lett. 2009, 103, 043902], i.e., a metamaterial-inspired ultranarrow waveguide channel operating near its cut-off frequency. Such system is not necessarily at resonance, but its peculiar operation may provide enhanced emission over a relatively broad physical area, which may allow enhancement of emission independent of the position of an individual or of a group of molecules along such plasmonic channel, and the possibility to bend and route the emitted energy with large flexibility. We present here extensive theoretical and numerical results that confirm this intuition and may envision a novel method for molecular emission enhancement at the nanoscale, with more flexibility than the conventional Purcell resonance techniques.

  10. Optimal cut-off values and population means of waist circumference in different populations.

    Science.gov (United States)

    Wang, Zhiqiang; Ma, Jun; Si, Damin

    2010-12-01

    Abdominal obesity is a risk factor for cardiometabolic disease, and has become a major public health problem in the world. Waist circumference is generally used as a simple surrogate marker to define abdominal obesity for population screening. An increasing number of publications solely rely on the method that maximises sensitivity and specificity to define 'optimal' cut-off values. It is well documented that the optimal cut-off values of waist circumference vary across different ethnicities. However, it is not clear if the variation in cut-off values is a true biological phenomenon or an artifact of the method for identifying optimal cut-off points. The objective of the present review was to assess the relationship between optimal cut-offs and population waist circumference levels. Among sixty-one research papers, optimal cut-off values ranged from 65·5 to 101·2 cm for women and 72·5 to 103·0 cm for men. Reported optimal cut-off values were highly correlated with population means (correlation coefficient: 0·91 for men and 0·93 for women). Such a strong association was independent of waist circumference measurement techniques or the health outcomes (dyslipidaemia, hypertension or hyperglycaemia), and existed in some homogeneous populations such as the Chinese and Japanese. Our findings raised some concerns about applying the sensitivity and specificity approach to determine cut-off values. Further research is needed to understand whether the differences among populations in waist circumference were genetically or environmentally determined, and to understand whether using region-specific cut-off points can identify individuals with the same absolute risk levels of metabolic and cardiovascular outcomes among different populations.

  11. Explaining the use of attribute cut-off values in decision making by means of involvement

    DEFF Research Database (Denmark)

    Peschel, Anne Odile; Grebitus, Carola; Colson, Gregory;

    2016-01-01

    evidence on consumers’ heterogeneous use of attribute cut-offs with a unique focus on the relationship with consumer involvement, a key component in consumer choice theory. Behavioral data from an online choice experiment on beef steak employing shelf simulations are combined with questions defining...... a latent class model identifies several key consumer segments (e.g., a price sensitive group) based on their choice behavior and reveals that the relationship between involvement, cut-off use and cut-off violations is not uniform across consumer segments....

  12. Human papillomavirus testing in primary cervical screening and the cut-off level for hybrid capture 2 tests

    DEFF Research Database (Denmark)

    Rebolj, Matejka; Bonde, Jesper; Njor, Sisse Helle;

    2011-01-01

    To determine the trade-off between the sensitivity and the specificity for high grade cervical intraepithelial neoplasia at hybrid capture 2 cut-off values above the standard = 1 relative light units/cut-off level (rlu/co)....

  13. The acoustic cut-off frequency of the Sun and the solar magnetic activity cycle

    CERN Document Server

    Jimenez, A; Palle, P L

    2011-01-01

    The acoustic cut-off frequency -the highest frequency for acoustic solar eigenmodes- is an important parameter of the solar atmosphere as it determines the upper boundary of the p-mode resonant cavities. At frequencies beyond this value, acoustic disturbances are no longer trapped but traveling waves. Interference amongst them give rise to higher-frequency peaks -the pseudomodes- in the solar acoustic spectrum. The pseudomodes are shifted slightly in frequency with respect to p modes making possible the use of pseudomodes to determine the acoustic cut-off frequency. Using data from GOLF and VIRGO instruments on board the SOHO spacecraft, we calculate the acoustic cut-off frequency using the coherence function between both the velocity and intensity sets of data. By using data gathered by these instruments during the entire lifetime of the mission (1996 till the present), a variation in the acoustic cut-off frequency with the solar magnetic activity cycle is found.

  14. Epidemiological cut-off values for Flavobacterium psychrophilum MIC data generated by a standard test protocol

    DEFF Research Database (Denmark)

    Smith, P.; Endris, R.; Kronvall, G.;

    2016-01-01

    Epidemiological cut-off values were developed for application to antibiotic susceptibility data for Flavobacterium psychrophilum generated by standard CLSI test protocols. The MIC values for ten antibiotic agents against Flavobacterium psychrophilum were determined in two laboratories. For five a...

  15. The Mass Shell of the Nelson Model without Cut-Offs

    CERN Document Server

    Bachmann, S; Pizzo, A

    2011-01-01

    The massless Nelson model describes non-relativistic, spinless quantum particles interacting with a relativistic, massless, scalar quantum field. The interaction is linear in the field. We analyze the one particle sector. First, we construct the renormalized mass shell of the non-relativistic particle for an arbitrarily small infrared cut-off that turns off the interaction with the low energy modes of the field. No ultraviolet cut-off is imposed. Second, we implement a suitable Bogolyubov transformation of the Hamiltonian in the infrared regime. This transformation depends on the total momentum of the system and is non-unitary as the infrared cut-off is removed. For the transformed Hamiltonian we construct the mass shell in the limit where both the ultraviolet and the infrared cut-off are removed. Our approach is constructive and leads to explicit expansion formulae which are amenable to rigorously control the S-matrix elements.

  16. Less pollution - less raw materials - less noise: Automatic cylinder cut-off technology

    Energy Technology Data Exchange (ETDEWEB)

    1987-01-01

    VW's automatic cylinder cut-off technology displays its advantages especially in city traffic - as road tests have proved. Though no fuel saving was measured on motorways it came up to 16% when driving on country roads and 30% in inner city traffic. One intends to use cylinder cut-off first for diesel cars as the restart reliability of diesel engines is much higher than that of petrol engines. (HW)

  17. Spin Cut-off Parameter of Nuclear Level Density and Effective Moment of Inertia

    Institute of Scientific and Technical Information of China (English)

    A.N. Behkami; M. Soltani

    2005-01-01

    The spin cut-off parameter of the nuclear level density and effective moment of inertia for a large number of nuclei have been determined from analysis of the experimental data on S-wave neutron resonances and spins of lowlying levels. Contrary to claims made before, it is shown the spin cut-off parameter differs considerably from their corresponding rigid body values, and the energy dependence of the effective moment of inertia confirms the interacting fermion model prediction.

  18. Cut-off wavenumber of Alfven waves in partially ionized plasmas of the solar atmosphere

    CERN Document Server

    Zaqarashvili, T V; Ballester, J L; Khodachenko, M L

    2012-01-01

    Alfven wave dynamics in partially ionized plasmas of the solar atmosphere shows that there is indeed a cut-off wavenumber, i.e. the Alfven waves with wavenumbers higher than the cut-off value are evanescent. The cut-off wavenumber appears in single-fluid magnetohydrodynamic (MHD) approximation but it is absent in a multi-fluid approach. Up to now, an explanation for the existence of the cut-off wavenumber is still missing. The aim of this paper is to point out the reason for the appearance of a cut-off wavenumber in single-fluid MHD. Beginning with three-fluid equations (with electrons, protons and neutral hydrogen atoms), we performed consecutive approximations until we obtained the usual single-fluid description is obtained. We solved the dispersion relation of linear Alfven waves at each step and sought the approximation responsible of the cut-off wavenumber appearance. We have found that neglecting inertial terms significantly reduces the real part of the Alfven frequency although it never becomes zero. T...

  19. Phase properties of the cut-off high-order harmonics

    CERN Document Server

    Khokhlova, M A

    2015-01-01

    The cut-off regime of high-order harmonic generation (HHG) by atoms in an intense laser field is studied numerically and analytically. We find that the cut-off regime is characterized by equal dephasing between the successive harmonics. The change of the harmonic phase-locking when HHG evolves from the cut-off to the plateau regime determines the optimal bandwidth of the spectral region which should be used for attosecond pulse generation via amplitude gating technique. The cut-off regime is also characterized by a linear dependence of the harmonic phase on the fundamental intensity. The proportionality coefficient grows as the cube of the fundamental wavelength, thus this dependence becomes very important for the HHG by mid-infrared fields. Moreover, for every high harmonic there is a {\\it range} of laser intensities providing the generation in the cut-off regime and the atomic response magnitude in this regime can be greater than that in the plateau regime. Thus the cut-off regime substantially contributes ...

  20. Effect of copper slag recovery on hydrometallurgical cut-off grades considering environmental aspects

    Institute of Scientific and Technical Information of China (English)

    AFSHIN AKBARI; ESMAEIL RAHIMI

    2016-01-01

    Determining the hydrometallurgical cut-off grades specifies the destination of low grade materials and this is subjected to more benefits in mining. Copper production rate is considered as one of the fundamental issues in hydrometallurgical cut-off grades determination. Slags are remarked as one of the main sources of copper. It is not only regarded as a waste but also identified as another resource extracting base metals. Slags are characterized by copper high grade. Thus, slag copper recovery can be led to different cut-off grades and net present value (NPV). The current research scrutinizes the effect of slag recovery by both flotation and hydrometallurgical methods on the hydrometallurgical cut-off grades. For this purpose, the optimum cut-off grade algorithms of hydrometallurgical methods are developed by considering associated environmental parameters, incomes and also the costs. Then, their optimum amounts are calculated with NPV maximization as an objective function. The results indicate that considering slag copper recovery in the hydrometallurgical cut-off grade algorithms reduces the environmental costs caused by slag dumping and leads to more NPV by 9%.

  1. Preoperative plasma D-dimer is a predictor of one-year survival in colorectal cancer patients: a prospective clinical cohort study

    DEFF Research Database (Denmark)

    Stender, Mogens; Larsen, Torben Bjerregaard; Frøkjær, J.B.;

    PURPOSE: The study examined if preoperative plasma D-dimer level was associated with the postoperative cumulative incidence of deep venous thrombosis in patients with colorectal cancer admitted for intended curative surgery. METHODS: In 176 consecutive patients with newly-diagnosed colorectal...... cancer and absence of preoperative deep venous thrombosis, we measured the preoperative plasma D-dimer levels and performed compression ultrasonography for deep venous thrombosis prior to surgery, as well as one week, one month, and one year after surgery. RESULTS: The cumulative incidence of deep venous...... thrombosis up to one year after surgery was 20 percent (95 percent confidence interval, 12 to 31 percent) in the positive D-dimer group compared with 5 percent (95 percent confidence interval, 2 to 12 percent) in the negative D-dimer group. The adjusted hazard ratio of deep venous thrombosis in the positive...

  2. Atmospheric structure and acoustic cut-off frequency of roAp stars

    CERN Document Server

    Audard, N; Morel, P; Provost, J P; Weiss, W W

    1998-01-01

    Some of the rapidly oscillating (CP2) stars, have frequencies which are larger than the theoretical acoustic cut-off frequency. As the cut-off frequency depends on the T(tau) relation in the atmosphere, we have computed models and adiabatic frequencies for pulsating Ap stars with T(tau) laws based on Kurucz model atmospheres and on Hopf's purely radiative relation. The frequency-dependent treatment of radiative transfer as well as an improved calculation of the radiative pressure in Kurucz model atmospheres increase the theoretical acoustic cut-off frequency by about 200 microHz, which is closer to the observations. For alpha Cir we find models with Kurucz atmospheres which have indeed a cut-off frequency beyond the largest observed frequency and which are well within the Teff - L error box. For HD 24712 only models which are hotter by about 100 K and less luminous by nearly 10% than what is actually the most probable value would have an acoustic cut-off frequency large enough. One may thus speculate that the...

  3. Calculating broad neutron resonances in a cut-off Woods-Saxon potential

    Energy Technology Data Exchange (ETDEWEB)

    Baran, A.; Noszaly, Cs. [Faculty of Informatics, University of Debrecen, PO Box 12, Debrecen (Hungary); Salamon, P. [Hungarian Academy of Sciences (ATOMKI), Institute for Nuclear Research, PO Box 51, Debrecen (Hungary); Vertse, T. [Faculty of Informatics, University of Debrecen, PO Box 12, Debrecen (Hungary); Hungarian Academy of Sciences (ATOMKI), Institute for Nuclear Research, PO Box 51, Debrecen (Hungary)

    2015-07-15

    In a cut-off Woods-Saxon (CWS) potential with realistic depth S -matrix poles being far from the imaginary wave number axis form a sequence where the distances of the consecutive resonances are inversely proportional with the cut-off radius value, which is an unphysical parameter. Other poles lying closer to the imaginary wave number axis might have trajectories with irregular shapes as the depth of the potential increases. Poles being close repel each other, and their repulsion is responsible for the changes of the directions of the corresponding trajectories. The repulsion might cause that certain resonances become antibound and later resonances again when they collide on the imaginary axis. The interaction is extremely sensitive to the cut-off radius value, which is an apparent handicap of the CWS potential. (orig.)

  4. Investigation of the negative-mass behaviors occurring below a cut-off frequency

    Energy Technology Data Exchange (ETDEWEB)

    Yao Shanshan; Zhou Xiaoming; Hu Gengkai, E-mail: zhxming@bit.edu.c, E-mail: hugeng@bit.edu.c [School of Aerospace Engineering, Beijing Institute of Technology, Beijing 100081 (China)

    2010-10-15

    Negative-mass phenomena occurring below a cut-off frequency are examined using both theoretical and experimental methods. The paper begins with an investigation of a mass-spring structure, the effective mass of which is shown to be negative below a specific frequency. Due to the decaying nature of lattice waves in the negative-mass system, the transmission drop induced by negative effective mass is demonstrated experimentally. Further investigation is conducted for a rectangular solid waveguide with clamped boundary conditions. It is shown that the lowest bandgap mode of the clamped waveguide can be attributed to negative effective mass below a cut-off frequency. Based on this observation, elastic metamaterials made of a steel grid filled with styrene butadiene rubber are designed and fabricated. Both the simulation and experimental analyses demonstrate that the designed metamaterials have negative effective mass below a cut-off frequency.

  5. Calculating broad neutron resonances in a cut-off Woods-Saxon potential

    CERN Document Server

    Baran, Á; Salamon, P; Vertse, T

    2015-01-01

    In a cut-off Woods-Saxon potential with realistic depth $S$-matrix poles being far from the imaginary wave number axis form a sequence where the distances of the consecutive resonances are inversely proportional with the cut-off radius value. Other poles lying closer to the imaginary wave number axis might have trajectories with irregular shapes as the depth of the potential increases. Poles being close repel each other, and their repulsion is responsible for the changes of the directions of the corresponding trajectories. The interaction is extremely sensitive to the cut-off radius value. The repulsion might cause that certain resonances become antibound and later resonances again when they collide on the imaginary axis.

  6. Secondary proton production at small atmospheric depths as a function of the geomagnetic cut-off

    Energy Technology Data Exchange (ETDEWEB)

    Papini, P. [Florence Univ. (Italy)]|[INFN, Florence (Italy); Grimani, C. [Perugia Univ. (Italy)]|[INFN, Perugia (Italy); Stephens, S.A. [Tata Institute of Fundamental Research, Bombay (International Commission on Radiation Units and Measurements)

    1995-09-01

    A detailed calculation of the energy spectrum of secondary protons in the atmosphere is being carried out in the energy range 20 MeV - 40 GeV. In this calculation, it is taken into account all processes leading to the production of secondary protons as a function of the atmospheric depth has been calculated using all relevant energy loss processes. In this paper, it is examine the effect of the geomagnetic cut-off on the spectral shape of secondary protons specially at energies below the geomagnetic cut-off for small atmospheric depths.

  7. Suppressing the weakly bound states in the photoassociation dynamics by using a frequency cut-off laser pulse

    Institute of Scientific and Technical Information of China (English)

    Lin Feng; Zhang Wei; Zhao Ze-Yu; Cong Shu-Lin

    2012-01-01

    The photoassociation dynamics of ultracold lithium atoms controlled by a cut-off pulse has been investigated theoretically by solving numerically the time-dependent Schr(o)dinger equation using the mapped Fourier grid method.The frequency components of the laser pulse close to the atomic resonance are partly cut off.Compared with the typical Gauss-type pulses,the cut-off pulse is helpful to suppress efficiently the weakly bound states and prepare the associated molecules in the lower vibrational states.Especially,the dependence of photoassociation probability on the cut-off position of the laser pulse is explored.

  8. Determination of a saliva cotinine cut-off to distinguish pregnant smokers from pregnant non-smokers

    DEFF Research Database (Denmark)

    Hegaard, Hanne K; Kjaergaard, Hanne; Møller, Lars F;

    2007-01-01

    Objective validation of smoking status is necessary. Earlier studies have used saliva cotinine concentrations between 14.2 and 30 ng/ml as cut-off values to distinguish pregnant smokers from non-smokers. However, these cut-offs derive from studies including men and non-pregnant women. This consti......Objective validation of smoking status is necessary. Earlier studies have used saliva cotinine concentrations between 14.2 and 30 ng/ml as cut-off values to distinguish pregnant smokers from non-smokers. However, these cut-offs derive from studies including men and non-pregnant women...

  9. Age- and sex-dependent reference intervals for D-dimer

    DEFF Research Database (Denmark)

    Haase, Christine; Joergensen, Maja; Ellervik, Christina;

    2013-01-01

    A low D-dimer is commonly used to exclude venous thromboembolism in low risk patients. However, the reference intervals are poorly defined and D-dimer has been shown to increase by patient age. We aimed to establish age- and sex-dependent D-dimer reference intervals and to test the consequence...

  10. Chronic kidney disease : Defining clinical cut-offs for albumin:creatinine ratio

    NARCIS (Netherlands)

    Bakker, Stephan J L

    2013-01-01

    Albuminuria is rapidly gaining recognition as a marker of the presence and of the progression of chronic kidney disease (CKD). In a new study, Naresh et al. attempt to define cut-off values for percentage change in urinary albumin:creatinine ratio that reflect changes in CKD status rather than rando

  11. Effective spectral density functions from finite cut-off frequencies of baths

    CERN Document Server

    Liang, Xian-Ting

    2009-01-01

    Firstly, we obtain the effective spectral density functions of baths for two basic open quantum systems by setting cut-off frequencies of the baths finite. By using the spectral density functions and the conventional ones from infinite cut-off frequency of the baths we investigate the dynamics of open qubits. When the cut-off frequencies of the baths are smaller than about 5 times of the Rabi frequency of the qubits, the two kinds of spectral density functions result in different qubits' dynamics. Secondly, we obtain the effective spectral density functions of the baths for another two complex models from finite cut-off frequencies of the baths and through which we investigate the dynamics of open qubits in these models. One of these models is a quantum system couple to an intermediate harmonic oscillator and both of them couple to their independent baths respectively, and the other is both of them couple to a common bath. The qubit in the later model has longer decoherence and relaxation times. In the invest...

  12. Rise time of proton cut-off energy in 2D and 3D PIC simulations

    CERN Document Server

    Babaei, Javad; Londrillo, Pasquale; Mirzanejad, Saeed; Rovelli, Tiziano; Sinigardi, Stefano; Turchetti, Giorgio

    2016-01-01

    The Target Normal Sheath Acceleration (TNSA) regime for proton acceleration by laser pulses is experimentally consolidated and fairly well understood. However, uncertainties remain in the analysis of particle-in-cell (PIC) simulation results. The energy spectrum is exponential with a cut-off, but the maximum energy depends on the simulation time, following different laws in two and three dimensional (2D, 3D) PIC simulations, so that the determination of an asymptotic value has some arbitrariness. We propose two empirical laws for rise time of the cut-off energy in 2D and 3D PIC simulations, suggested by a model in which the proton acceleration is due to a surface charge distribution on the target rear side. The kinetic energy of the protons that we obtain follows two distinct laws, which appear to be nicely satisfied by PIC simulations. The laws depend on two parameters: the scaling time, at which the energy starts to rise, and the asymptotic cut-off energy. The values of the cut-off energy, obtained by fitti...

  13. Prevalensi Sarkopenia pada Lansia di Komunitas (Community Dwelling berdasarkan Dua Nilai Cut-off Parameter Diagnosis

    Directory of Open Access Journals (Sweden)

    Vitriana

    2016-09-01

    Full Text Available Sarcopenia, aging muscle mass loss, and function syndromes can lead to decreased quality of life and increased elderly mortality. The availability of various screening methods and operational definitions in different studies has produced different findings of sarcopenia prevalence. The purpose of this study was to discover the prevalence of sarcopenia in Indonesian community-dwelling elderly based on muscle mass measured by bioimpedance analysis, handgrip strength using hand dynamometer, and physical performance based on six minutes walking test with two different cut-off point parameters of sarcopenia, i.e. the cut-off point recommended by Asian Working Group for Sarcopenia (AWGS and the cut-off point based on the reference used in Taiwan elderly population reference due to the lack of references for Indonesian elderly population. A cross-sectional study was conducted to 229 participants (71 men and 158 women from the community-dwelling elderly population between August and December 2014 in Bandung and Jatinangor. The results of the study showed that the sarcopenia prevalence in this study based on AWGS was 9.1% (7.4% in men and 1.7% in women while the prevalence based on the Taiwan reference revealed a prevalence of 40.6% (20.1% in men and 20.5% in women. This highly different prevalences shows the importance of defining a specific cut-off point for elderly population in community-dwelling Indonesia to get a more accurate sarcopenia prevalence.

  14. 76 FR 33161 - Installation and Use of Engine Cut-off Switches on Recreational Vessels

    Science.gov (United States)

    2011-06-08

    ... will then become highlighted in blue. In the ``Document Type'' drop down menu select ``Proposed Rule...'' box, which will then become highlighted in blue. In the ``Keyword'' box, insert ``USCG-2009-0206'' and... and impose a smaller burden on the economy,'' and specifically noted engine cut-off switches...

  15. A New Regularization Mechanism for the Boltzmann Equation Without Cut-Off

    Science.gov (United States)

    Silvestre, Luis

    2016-11-01

    We apply recent results on regularity for general integro-differential equations to derive a priori estimates in Hölder spaces for the space homogeneous Boltzmann equation in the non cut-off case. We also show an a priori estimate in {L^∞} which applies in the space inhomogeneous case as well, provided that the macroscopic quantities remain bounded.

  16. Establishing streptomycin epidemiological cut-off values for Salmonella and Escherichia coli. Microbial Drug Resistance

    NARCIS (Netherlands)

    Garcia-Migura, L.; Sunde, M.; Karlsmose, S.; Veldman, K.T.; Schroeter, A.; Guerra, B.; Granier, S.A.; Perrin-Guyomard, A.; Gicquel-Bruneau, M.; Franco, A.; Englund, S.; Teale, C.; Heiska, H.; Clemente, L.; Boerlin, P.; Moreno, M.A.; Daignault, D.; Mevius, D.J.; Hendriksen, R.S.; Aarestrup, F.M.

    2012-01-01

    This study was conducted to elucidate the accuracy of the current streptomycin epidemiological cut-off value (ECOFF) for Escherichia coli and Salmonella spp. A total of 236 Salmonella enterica and 208 E. coli isolates exhibiting MICs between 4 and 32¿mg/L were selected from 12 countries. Isolates we

  17. Comparison of different DIAGNOdent cut-off limits for in vivo detection of occlusal caries.

    Science.gov (United States)

    Heinrich-Weltzien, Roswitha; Kühnisch, J; Oehme, T; Ziehe, A; Stösser, L; García-Godoy, F

    2003-01-01

    This study tested recently recommended cut-off limits for the laser fluorescence based device DIAGNOdent (KaVo) for detection of occlusal caries. Two hundred and forty-eight permanent molars from 94 patients (mean age 19.2 years) of a general dental practice were included. After professional tooth cleaning, the teeth were examined visually and by the laser fluorescence method. The extent of occlusal lesions (gold standard) was determined after minimal operative intervention. Upon fissure opening, 24 teeth had enamel caries and 224 teeth revealed dentin caries, of which 58 and 166, respectively, were up to or beyond half the dentin. The optimal cut-off limits based on the highest kappa-values (0.51 and 0.54) were > 18 for superficial dentinal caries (D3) and > 37 for deep dentinal caries (D4). The comparison with DIAGNOdent cut-offs given by the manufacturer (n = 4) and those based on clinical trials with in vivo validation (n = 4) and in vitro studies with histological validation (n = 3) revealed a considerable variation in performance. Recommended cut-offs between 17 and 21 for superficial dentin lesions were in the same order of magnitude (0.48-0.51). On the D4 level, only the manufacturer's cut-off of > 34 achieved the best performance (0.51). According to the highest kappa-values and the area under the ROC curves (D3: A(z) = 0.903; D4: A(z) = 0.830), the agreement between the extent of validated caries and laser fluorescence value is still unsatisfactory.

  18. Raised BMI cut-off for overweight in Greenland Inuit – a review

    Directory of Open Access Journals (Sweden)

    Stig Andersen

    2013-08-01

    Full Text Available Background. Obesity is associated with increased morbidity and premature death. Obesity rates have increased worldwide and the WHO recommends monitoring. A steep rise in body mass index (BMI, a measure of adiposity, was detected in Greenland from 1963 to 1998. Interestingly, the BMI starting point was in the overweight range. This is not conceivable in a disease-free, physically active, pre-western hunter population. Objective. This led us to reconsider the cut-off point for overweight among Inuit in Greenland. Design and findings. We found 3 different approaches to defining the cut-off point of high BMI in Inuit. First, the contribution to the height by the torso compared to the legs is relatively high. This causes relatively more kilograms per centimetre of height that increases the BMI by approximately 10% compared to Caucasian whites. Second, defining the cut-off by the upper 90-percentile of BMI from height and weight in healthy young Inuit surveyed in 1963 estimated the cut-off point to be around 10% higher compared to Caucasians. Third, if similar LDL-cholesterol and triglycerides are assumed for a certain BMI in Caucasians, the corresponding BMI in Inuit in both Greenland and Canada is around 10% higher. However, genetic admixture of Greenland Inuit and Caucasian Danes will influence this difference and hamper a clear distinction with time. Conclusion. Defining overweight according to the WHO cut-off of a BMI above 25 kg/m2 in Greenland Inuit may overestimate the number of individuals with elevated BMI.

  19. Multiple Sclerosis Questionnaire for Job Difficulties (MSQ-Job): definition of the cut-off score.

    Science.gov (United States)

    Schiavolin, Silvia; Giovannetti, Ambra Mara; Leonardi, Matilde; Brenna, Greta; Brambilla, Laura; Confalonieri, Paolo; Frangiamore, Rita; Mantegazza, Renato; Moscatelli, Marco; Clerici, Valentina Torri; Cortese, Francesca; Covelli, Venusia; Ponzio, Michela; Zaratin, Paola; Raggi, Alberto

    2016-05-01

    Multiple Sclerosis (MS) mainly affects people of working age. The Multiple Sclerosis Questionnaire for Job Difficulties (MSQ-Job) was designed to measure difficulties in work-related tasks. Our aim is to define cut-off score of MSQ-Job to identify potential critical situations that might require specific attention. A sample of patients with MS completed the MSQ-Job, WHODAS 2.0 and MSQOL-54 respectively for work difficulties, disability and health-related quality of life (HRQoL) evaluation. K-means Cluster Analysis was used to divide the sample in three groups on the basis of HRQoL and disability. ANOVA test was performed to compare the response pattern between these groups. The cut-off score was defined using the receiver operating characteristic (ROC) curve analyses for MSQ-Job total and count of MSQ-Job items scores ≥3: a score value corresponding to the maximum of the sensitivity-to-specificity ratio was chosen as the cut-off. Out of 180 patients enrolled, twenty were clustered in the higher severity group. The area under the ROC curve was 0.845 for the MSQ-Job total and 0.859 for the count of MSQ-Job items scores ≥3 while the cut-off score was 15.8 for MSQ-Job total and 8 for count of items scored ≥3. We recommend the use of MSQ-Job with this calculation as cut-off for identifying critical situations, e.g. in vocational rehabilitation services, where work-related difficulties have a significant impact in terms of lower quality of life and higher disability.

  20. THE INTEGRAL HIGH-ENERGY CUT-OFF DISTRIBUTION OF TYPE 1 ACTIVE GALACTIC NUCLEI

    Energy Technology Data Exchange (ETDEWEB)

    Malizia, A.; Molina, M.; Bassani, L.; Stephen, J. B. [IASF-Bologna, INAF, Via Gobetti 101, I-40129 Bologna (Italy); Bazzano, A.; Ubertini, P. [IAPS-Roma, INAF, Via Fosso del Cavaliere 100, I-00133 Roma (Italy); Bird, A. J., E-mail: malizia@iasfbo.inaf.it [School of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ (United Kingdom)

    2014-02-20

    In this Letter we present the primary continuum parameters, the photon index Γ, and the high-energy cut-off E {sub c} of 41 type-1 Seyfert galaxies extracted from the International Gamma-Ray Astrophysics Laboratory (INTEGRAL) complete sample of active galactic nuclei (AGNs). We performed broadband (0.3-100 keV) spectral analysis by simultaneously fitting the soft and hard X-ray spectra obtained by XMM and INTEGRAL/IBIS-Swift/BAT, respectively, in order to investigate the general properties of these parameters, in particular their distribution and mean values. We find a mean photon index of 1.73 with a standard deviation of 0.17 and a mean high-energy cut-off of 128 keV with a standard deviation of 46 keV for the whole sample. This is the first time that the cut-off energy is constrained in such a large number of AGNs. We have 26 measurements of the cut-off, which corresponds to 63% of the entire sample, distributed between 50 and 200 keV. There are a further 11 lower limits mostly below 300 keV. Using the main parameters of the primary continuum, we have been able to obtain the actual physical parameters of the Comptonizing region, i.e., the plasma temperature kT {sub e} from 20 to 100 keV and the optical depth τ < 4. Finally, with the high signal-to-noise ratio spectra starting to come from NuSTAR it will soon be possible to better constrain the cut-off values in many AGNs, allowing the determination of more physical models and thus better understand the continuum emission and geometry of the region surrounding black holes.

  1. D-dimer testing for safe exclusion and risk stratification in patients with acute pulmonary embolism in primary care

    Directory of Open Access Journals (Sweden)

    Zhou Yin

    2015-01-01

    Full Text Available Background: Safe exclusion and risk stratification are currently recommended for the initial management of patients with acute pulmonary embolism (APE. The aim of this study was to assess the safe exclusion and risk stratification value of D-dimer (DD for APE when tested at the beginning of admission. Materials and Methods: All consecutive Chinese APE patients and controls were recruited from January 2010 to December 2012. All measurements of serum indexes were made in duplicate and blinded to the patients′ status. All the 40 patients with the first episode of APE were confirmed by multi-detector computed tomographic pulmonary angiography. The plasma prothrombin time (PT, activated partial thromboplastin time, thrombin time, fibrinogen, and DD levels were measured within 24 h of admission. We used the Mann-Whitney U-test to determine the differences between groups and drew receiver operator characteristic curve to evaluate the indexes′ value in the APE screening. Results: The PT and DD in the APE group were significantly higher than those in the disease control group (P 1820 μg/L as cut-off value, the sensitivity, specificity, positive and negative predictive value was 82.5%, 75.2%, 56.9%, and 91.6%, respectively. Conclusion: The patients with APE showed significant higher DD levels compared with disease controls, suggesting a negative qualitative DD test result can safely and efficiently exclude APE in primary care.

  2. Methodological issues in the design of a rheumatoid arthritis activity score and its cut-offs

    Directory of Open Access Journals (Sweden)

    Collignon O

    2014-07-01

    Full Text Available Olivier Collignon Centre de Recherche Public de la Santé (CRP-Santé, Competences Centre for Methodology and Statistics (CCMS, Strassen, Luxembourg Abstract: Activity of rheumatoid arthritis (RA can be evaluated using several scoring scales based on clinical features. The most widely used one is the Disease Activity Score involving 28 joint counts (DAS28 for which cut-offs were proposed to help physicians classify patients. However, inaccurate scoring can lead to inappropriate medical decisions. In this article some methodological issues in the design of such a score and its cut-offs are highlighted in order to further propose a strategy to overcome them. As long as the issues reviewed in this article are not addressed, results of studies based on standard disease activity scores such as DAS28 should be considered with caution. Keywords: DAS28, disease activity score, penalized logistic regression, clinical prediction, modeling

  3. Edge plasmons and cut-off behavior of graphene nano-ribbon waveguides

    Science.gov (United States)

    Hou, Haowen; Teng, Jinghua; Palacios, Tomás; Chua, Soojin

    2016-07-01

    Graphene nano-ribbon waveguides with ultra-short plasmon wavelength are a promising candidate for nanoscale photonic applications. Graphene edge plasmons are the fundamental and lowest losses mode. Through finite element method, edge plasmons show large effective refractive index and strong field confinement on nanoscale ribbons. The edge plasmons follow a k1/2 dispersion relation. The wavelengths of the edge plasmons and center plasmons differ by a fixed factor. The width of edge plasmon is inversely proportional to wave vector of edge plasmon kedge. Edge defects associate with graphene nano-ribbon induce extra losses and reduce the propagation length. Cut-off width of edge plasmons reduces with increasing frequency. Cut-off width of center plasmon is enlarged by edge component but the enlargement effect diminishing with the increase of kedge. The results are important for the application of graphene plasmon towards ultra-compact photonic devices.

  4. Correlation analysis between plasma D-dimer levels and orthopedic trauma severity

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li-dan; LIU Hong-bo; LI Yu-neng; MA Hai-mei; LIU Ya-bo; WANG Man-yi

    2012-01-01

    Background The correlation between the plasma D-dimer level and deep vein thrombosis has not been conclusive in various studies.The aim of this research was to study the relationship between plasma D-dimer levels and the severity of orthopedic trauma by retrospective examination of orthopedic trauma cases.Methods Clinically acute trauma and non-acute trauma patients were selected and their plasma D-dimer levels were measured.Plasma D-dimer levels in patients of these two groups were compared.The relationship between the plasma D-dimer level and the severity of the trauma was also studied.Results There were 548 cases in the acute trauma group and 501 cases in the non-acute trauma group.The levels of plasma D-dimer were significantly higher in the acute trauma group than in the non-acute trauma group (P <0.01).In the acute trauma group,the correlation between the D-dimer level and the number of fractures was a positive linear correlation (r=0.9532).Conclusions Elevated plasma D-dimer is common in trauma patients.The D-dimer level and the number of fractures in the trauma patients are closely correlated.D-dimer is not only an indicator for the diagnosis of deep vein thrombosis and pulmonary embolus,but also an indicator of the severity of trauma in acute trauma patients.

  5. Introduction of a distance cut-off into structural alignment by the double dynamic programming algorithm.

    Science.gov (United States)

    Toh, H

    1997-08-01

    Two approximations were introduced into the double dynamic programming algorithm, in order to reduce the computational time for structural alignment. One of them was the so-called distance cut-off, which approximately describes the structural environment of each residue by its local environment. In the approximation, a sphere with a given radius is placed at the center of the side chain of each residue. The local environment of a residue is constituted only by the residues with side chain centers that are present within the sphere, which is expressed by a set of center-to-center distances from the side chain of the residue to those of all the other constituent residues. The residues outside the sphere are neglected from the local environment. Another approximation is associated with the distance cut-off, which is referred to here as the delta N cut-off. If two local environments are similar to each other, the numbers of residues constituting the environments are expected to be similar. The delta N cut-off was introduced based on the idea. If the difference between the numbers of the constituent residues of two local environments is greater than a given threshold value, delta N, the evaluation of the similarity between the local environments is skipped. The introduction of the two approximations dramatically reduced the computational time for structural alignment by the double dynamic programming algorithm. However, the approximations also decreased the accuracy of the alignment. To improve the accuracy with the approximations, a program with a two-step alignment algorithm was constructed. At first, an alignment was roughly constructed with the approximations. Then, the epsilon-suboptimal region for the alignment was determined. Finally, the double dynamic programming algorithm with full structural environments was applied to the residue pairs within the epsilon-suboptimal region to produce an improved alignment.

  6. Method and systems for power control of internal combustion engines using individual cycle cut-off

    Energy Technology Data Exchange (ETDEWEB)

    Fedorenko, Y.; Korzhov, M.; Filippov, A.; Atamanenko, N.

    1996-09-01

    A new method of controlling power has been developed for improving efficiency and emissions performance of internal combustion engines at partial load. The method involves cutting-off some of the work cycles, as the load decreases, to obtain required power. Theoretical and experimental material is presented to illustrate the underlying principle, the implementation means and the results for the 4- and 8-cylinder piston engine and a twin rotor Wankel engine applications.

  7. A framework for cut-off sampling in business survey design

    OpenAIRE

    Bee, Marco; Benedetti, Roberto; Espa, Giuseppe

    2007-01-01

    In sampling theory the large concentration of the population with respect to most surveyed variables constitutes a problem which is difficult to tackle by means of classical tools. One possible solution is given by cut-off sampling, which explicitly prescribes to discard part of the population; in particular, if the population is composed by firms or establishments, the method results in the exclusion of the “smallest” firms. Whereas this sampling scheme is common among practitioners, its the...

  8. Evaluation of novel large cut-off ultrafiltration membranes for adenovirus serotype 5 (Ad5 concentration.

    Directory of Open Access Journals (Sweden)

    Piergiuseppe Nestola

    Full Text Available The purification of virus particles and viral vectors for vaccine and gene therapy applications is gaining increasing importance in order to deliver a fast, efficient, and reliable production process. Ultrafiltration (UF is a widely employed unit operation in bioprocessing and its use is present in several steps of the downstream purification train of biopharmaceuticals. However, to date few studies have thoroughly investigated the performance of several membrane materials and cut-offs for virus concentration/diafiltration. The present study aimed at developing a novel class of UF cassettes for virus concentration/diafiltration. A detailed study was conducted to evaluate the effects of (i membrane materials, namely polyethersulfone (PES, regenerated cellulose (RC, and highly cross-linked RC (xRC, (ii nominal cut-off, and (iii UF device geometry at different production scales. The results indicate that the xRC cassettes with a cut-off of approximately 500 kDa are able to achieve a 10-fold concentration factor with 100% recovery of particles with a process time twice as fast as that of a commercially available hollow fiber. DNA and host cell protein clearances, as well as hydraulic permeability and fouling behavior, were also assessed.

  9. Evaluation of novel large cut-off ultrafiltration membranes for adenovirus serotype 5 (Ad5) concentration.

    Science.gov (United States)

    Nestola, Piergiuseppe; Martins, Duarte L; Peixoto, Cristina; Roederstein, Susanne; Schleuss, Tobias; Alves, Paula M; Mota, José P B; Carrondo, Manuel J T

    2014-01-01

    The purification of virus particles and viral vectors for vaccine and gene therapy applications is gaining increasing importance in order to deliver a fast, efficient, and reliable production process. Ultrafiltration (UF) is a widely employed unit operation in bioprocessing and its use is present in several steps of the downstream purification train of biopharmaceuticals. However, to date few studies have thoroughly investigated the performance of several membrane materials and cut-offs for virus concentration/diafiltration. The present study aimed at developing a novel class of UF cassettes for virus concentration/diafiltration. A detailed study was conducted to evaluate the effects of (i) membrane materials, namely polyethersulfone (PES), regenerated cellulose (RC), and highly cross-linked RC (xRC), (ii) nominal cut-off, and (iii) UF device geometry at different production scales. The results indicate that the xRC cassettes with a cut-off of approximately 500 kDa are able to achieve a 10-fold concentration factor with 100% recovery of particles with a process time twice as fast as that of a commercially available hollow fiber. DNA and host cell protein clearances, as well as hydraulic permeability and fouling behavior, were also assessed.

  10. Cut-off proposal for the detection of ketamine in hair.

    Science.gov (United States)

    Salomone, A; Gerace, E; Diana, P; Romeo, M; Malvaso, V; Di Corcia, D; Vincenti, M

    2015-03-01

    Ketamine is a powerful anesthetic drug used in both human and veterinary surgery, but it is also commonly misused because of its psychotropic properties. Since the abuse of this drug has been reported in many countries worldwide, its determination in hair samples is offered as a specialist test by hundreds of laboratories. However, unlike other common drugs of abuse, a cut-off level for ketamine in hair has not been fixed yet. Therefore, aim of this study is to propose a concentration value for ketamine in hair analysis, in order to discriminate between chronic and occasional use, and between active use and external contamination. After considering the chemical properties of this molecule, and the experimental data collected in our laboratory or reported in several other published studies, we propose a cut-off level of 0.5ng/mg, as indicative of repeated exposure to ketamine. Additionally, we suggest that the detection of the metabolite norketamine should be mandatory to prove active intake and exclude false positive result from external contamination. Thus, a reasonable cut-off value for norketamine could be fixed at 0.1ng/mg, while the minimal concentration ratio norketamine/ketamine may be positively established at 0.05.

  11. Clustered star formation as a natural explanation for the Halpha cut-off in disk galaxies.

    Science.gov (United States)

    Pflamm-Altenburg, Jan; Kroupa, Pavel

    2008-10-02

    The rate of star formation in a galaxy is often determined by the observation of emission in the Halpha line, which is related to the presence of short-lived massive stars. Disk galaxies show a strong cut-off in Halpha radiation at a certain galactocentric distance, which has led to the conclusion that star formation is suppressed in the outer regions of disk galaxies. This is seemingly in contradiction to recent observations in the ultraviolet which imply that disk galaxies have star formation beyond the Halpha cut-off, and that the star-formation-rate surface density is linearly related to the underlying gas surface density, which is a shallower relationship than that derived from Halpha luminosities. In a galaxy-wide formulation, the clustered nature of star formation has recently led to the insight that the total galactic Halpha luminosity is nonlinearly related to the galaxy-wide star formation rate. Here we show that a local formulation of the concept of clustered star formation naturally leads to a steeper radial decrease in the Halpha surface luminosity than in the star-formation-rate surface density, in quantitative agreement with the observations, and that the observed Halpha cut-off arises naturally.

  12. Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy.

    Directory of Open Access Journals (Sweden)

    Birgit Grund

    Full Text Available Despite effective antiretroviral treatment (ART, HIV-positive individuals are at increased risk of serious non-AIDS conditions (cardiovascular, liver and renal disease, and cancers, perhaps due in part to ongoing inflammation and/or coagulation. To estimate the potential risk reduction in serious non-AIDS conditions or death from any cause that might be achieved with treatments that reduce inflammation and/or coagulation, we examined associations of interleukin-6 (IL-6, D-dimer, and high-sensitivity C-reactive protein (hsCRP levels with serious non-AIDS conditions or death in 3 large cohorts.In HIV-positive adults on suppressive ART, associations of IL-6, D-dimer, and hsCRP levels at study entry with serious non-AIDS conditions or death were studied using Cox regression. Hazard ratios (HR adjusted for age, gender, study, and regression dilution bias (due to within-person biomarker variability were used to predict risk reductions in serious non-AIDS conditions or death associated with lower "usual" levels of IL-6 and D-dimer.Over 4.9 years of mean follow-up, 260 of the 3766 participants experienced serious non-AIDS conditions or death. IL-6, D-dimer and hsCRP were each individually associated with risk of serious non-AIDS conditions or death, HR = 1.45 (95% CI: 1.30 to 1.63, 1.28 (95% CI: 1.14 to 1.44, and 1.17 (95% CI: 1.09 to 1.26 per 2x higher biomarker levels, respectively. In joint models, IL-6 and D-dimer were independently associated with serious non-AIDS conditions or death, with consistent results across the 3 cohorts and across serious non-AIDS event types. The association of IL-6 and D-dimer with serious non-AIDS conditions or death was graded and persisted throughout follow-up. For 25% lower "usual" IL-6 and D-dimer levels, the joint biomarker model estimates a 37% reduction (95% CI: 28 to 46% in the risk of serious non-AIDS conditions or death if the relationship is causal.Both IL-6 and D-dimer are independently associated with

  13. Determination of a saliva cotinine cut-off to distinguish pregnant smokers from pregnant non-smokers

    DEFF Research Database (Denmark)

    Hegaard, Hanne K; Kjaergaard, Hanne; Møller, Lars F;

    2007-01-01

    Objective validation of smoking status is necessary. Earlier studies have used saliva cotinine concentrations between 14.2 and 30 ng/ml as cut-off values to distinguish pregnant smokers from non-smokers. However, these cut-offs derive from studies including men and non-pregnant women....... This constitutes a problem, as recent studies have reported an accelerated metabolism in pregnant smokers. The aim of this study was to determine the optimum cut-off cotinine level distinguishing pregnant smokers from pregnant non-smokers....

  14. [Clinical use of D-dimer in patients with cancer].

    Science.gov (United States)

    Lecumberri, Ramón; Pegenaute, Carlota; Páramo, José A

    2011-10-15

    There is a well-known close relationship between cancer and the haemostatic system. Plasma D-dimer (DD) is a marker of fibrin generation and lysis. In the clinical practice, its main use is in the diagnostic algorithms of venous thromboembolism (VTE), and it is one of the diagnostic criteria of disseminated intravacular coagulation. In patients with cancer, the specificity of DD is lower than in the general population, reducing its usefulness. However, there is a growing evidence that points out a possible application of DD in the clinical management of cancer patients as a predictor of VTE, marker of hidden cancer in patients with idiopathic VTE, or even as an independent prognostic factor of response to chemotherapy and survival. In this review, the current evidence supporting the use of DD in cancer patients is critically exposed and discussed.

  15. Brug af D-dimer til at udelukke dyb venøs trombose i overekstremiteterne

    DEFF Research Database (Denmark)

    Ahler-Toftehøj, Hans-Ulrik; Mikkelsen, Peter

    2009-01-01

    D-dimer is often used to exclude deep venous thrombosis, primarily in the lower extremities. We describe a 38-year-old man who had deep venous thrombosis in the left vena subclavia in spite of a normal D-dimer. Only one inconclusive survey compares the value of D-dimer and upper extremity deep...... venous thrombosis. We conclude that where deep venous thrombosis of the upper extremities is suspected, you cannot rely on the D-dimer value, but should examine the patient using other modalities such as colour Doppler ultrasound. Udgivelsesdato: 2009-Sep...

  16. Cut-off wavenumber of Alfvén waves in partially ionized plasmas of the solar atmosphere

    Science.gov (United States)

    Zaqarashvili, T. V.; Carbonell, M.; Ballester, J. L.; Khodachenko, M. L.

    2012-08-01

    Context. Alfvén wave dynamics in partially ionized plasmas of the solar atmosphere shows that there is indeed a cut-off wavenumber, i.e. the Alfvén waves with wavenumbers higher than the cut-off value are evanescent. The cut-off wavenumber appears in single-fluid magnetohydrodynamic (MHD) approximation but it is absent in a multi-fluid approach. Up to now, an explanation for the existence of the cut-off wavenumber is still missing. Aims: The aim of this paper is to point out the reason for the appearance of a cut-off wavenumber in single-fluid MHD. Methods: Beginning with three-fluid equations (with electrons, protons and neutral hydrogen atoms), we performed consecutive approximations until we obtained the usual single-fluid description. We solved the dispersion relation of linear Alfvén waves at each step and sought the approximation responsible of the cut-off wavenumber appearance. Results: We have found that neglecting inertial terms significantly reduces the real part of the Alfvén frequency although it never becomes zero. Therefore, the cut-off wavenumber does not exist at this stage. However, when the inertial terms together with the Hall term in the induction equation are neglected, the real part of the Alfvén frequency becomes zero. Conclusions: The appearance of a cut-off wavenumber, when Alfvén waves in partially ionized regions of the solar atmosphere are studied, is the result of neglecting inertial and Hall terms, therefore it has no physical origin.

  17. Energy loss in unstable QGP - problem of the upper cut-off

    Directory of Open Access Journals (Sweden)

    Carrington Margaret E.

    2014-04-01

    Full Text Available The energy loss of a highly energetic parton in a weakly coupled quark-gluon plasma is studied as an initial value problem. An extremely prolate plasma, where the momentum distribution is infinitely elongated along one direction, is considered. The energy loss is strongly time and direction dependent and its magnitude can much exceed the equilibrium value. It is logarithmically ultraviolet divergent. We argue that a good approximation to the energy loss can be obtained if this divergence is cut off with the parton energy.

  18. Renormalization and Computation II: Time Cut-off and the Halting Problem

    CERN Document Server

    Manin, Yuri I

    2009-01-01

    This is the second installment to the project initiated in [Ma3]. In the first Part, I argued that both philosophy and technique of the perturbative renormalization in quantum field theory could be meaningfully transplanted to the theory of computation, and sketched several contexts supporting this view. In this second part, I address some of the issues raised in [Ma3] and provide their development in three contexts: a categorification of the algorithmic computations; time cut--off and Anytime Algorithms; and finally, a Hopf algebra renormalization of the Halting Problem.

  19. Aligning DNA on Si surface and cutting off by tips of atomic force microscope

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    DNA is a kind of promising molecule as nano-lead to build or connect nano-devices due to its stable linear structure and certain conductivity. Many methods have been applied to constructing nano-patterns by using DNA molecule. In this report it is presented that (-DNA was aligned on Si substrate by using the free-flowing method and then imaged by an atomic force microscope (AFM). After the second liquid flow, a catenary-like pattern and a crossed network of -DNA were formed. In addition, the aligned (-DNA was successfully cut off by tips of AFM.

  20. Sensitivity studies of spin cut-off models on fission fragment observables

    Directory of Open Access Journals (Sweden)

    Thulliez L.

    2016-01-01

    Full Text Available A fission fragment de-excitation code, FIFRELIN, is being developed at CEA Cadarache. It allows probing the characteristics of the prompt emitted particles, neutrons and gammas, during the de-excitation process of fully accelerated fission fragments. The knowledge of the initial states of the fragments is important to accurately reproduce the fission fragment observables. In this paper a sensitivity study of various spin cut-off models, completely defining the initial fission fragment angular momentum distribution has been performed. This study shows that the choice of the model has a significant impact on gamma observables such as spectrum and multiplicity and almost none on the neutron observables.

  1. On the discovery of the Greisen–Zatzepin–Kuzmin cut-off

    Indian Academy of Sciences (India)

    Tadeusz Wibig

    2009-11-01

    The recent claim of the `5 sigma' observation of the Greisen–Zatzepin–Kuzmin cut-off by the HiRes group based on their nine years data is a significant step towards the eventual solution of one of the most intriguing questions in physics for more than 40 years. Recent results from Pierre Auger Observatory seem to confirm the statement. However, the word `significance' is used in the mentioned paper in a sense which is not quite obvious. In the present paper we argue that this claim is a little premature.

  2. Dimensional versus cut-off renormalization and the nucleon-nucleon interaction

    CERN Document Server

    Ghosh, A; Talukdar, B; Ghosh, Angsula; Adhikari, Sadhan K.

    1998-01-01

    The role of dimensional regularization is discussed and compared with that of cut-off regularization in some quantum mechanical problems with ultraviolet divergence in two and three dimensions with special emphasis on the nucleon-nucleon interaction. Both types of renormalizations are performed for attractive divergent one- and two-term separable potentials, a divergent tensor potential, and the sum of a delta function and its derivatives. We allow energy-dependent couplings, and determine the form that these couplings should take if equivalence between the two regularization schemes is to be enforced. We also perform renormalization of an attractive separable potential superposed on an analytic divergent potential.

  3. Dimensional versus cut-off renormalization and the nucleon-nucleon interaction

    Science.gov (United States)

    Ghosh, Angsula; Adhikari, Sadhan K.; Talukdar, B.

    1998-10-01

    The role of dimensional regularization is discussed and compared with that of cut-off regularization in some quantum mechanical problems with ultraviolet divergence in two and three dimensions with special emphasis on the nucleon-nucleon interaction. Both types of renormalizations are performed for attractive divergent one- and two-term separable potentials, a divergent tensor potential, and the sum of a delta function and its derivatives. We allow energy-dependent couplings, and determine the form that these couplings should take if equivalence between the two regularization schemes is to be enforced. We also perform renormalization of an attractive separable potential superposed on an analytic divergent potential.

  4. Evaluation of Serum D-dimer Levels in Children with Pneumonia

    Directory of Open Access Journals (Sweden)

    Nilgün Selçuk Duru

    2016-03-01

    Full Text Available Aim: The aim of this study was to investigate the relationship of plasma D-dimer levels with duration of hospitalization and radiological and laboratory findings in patients with pneumonia. Methods: Forty-seven patients with pneumonia (31 boys and 16 girls, mean age: 4.2±4.7 years were included in the study. The patients were divided into two groups according to duration of hospitalization and three groups according to radiological findings. D-dimer and other laboratory findings were compared between the groups. Results: The mean serum D-dimer level was 1333.5±1364.4 ng/L. There was no statistically significant difference in D-dimer, leukocyte, erythrocyte sedimentation rate (ESR and C-reactive protein (CRP between the groups divided according to duration of hospitalization. In addition, there was no statistically difference in D-dimer levels between the groups divided according to radiological findings. Age, percentage of neutrophils, ESR and fibrinogen levels were higher in patients with lobar pneumonia when compared with the other groups and CRP level was higher in lobar pneumonia group when compared to interstitial pneumonia group. D-dimer levels were negatively correlated with age and positively correlated with ESR, CRP, and fibrinogen. Conclusion: In our study, D-dimer levels were high in patient with pneumonia. Further studies with a larger number of patients are necessary to determine the role of D-dimer levels as an acutephase reactant in patients with pneumonia

  5. Genetic predictors of fibrin D-dimer levels in healthy adults

    NARCIS (Netherlands)

    N.L. Smith (Nicholas); J.E. Huffman (Jennifer E.); D.P. Strachan (David); J. Huang (Jian); A. Dehghan (Abbas); S. Trompet (Stella); L.M. Lopez (Lorna M.); S.Y. Shin (So Youn); J. Baumert (Jens); V. Vitart (Veronique); J.C. Bis (Joshua); S.H. Wild (Sarah); A. Rumley (Ann); Q. Yang (Qiong Fang); A.G. Uitterlinden (André); D.J. Stott (David. J.); G. Davies (Gareth); A.M. Carter (Angela M.); B. Thorand (Barbara); O. Polašek (Ozren); B. McKnight (Barbara); H. Campbell (Harry); A.R. Rudnicka (Alicja); M.H. Chen (Min-hsin); B.M. Buckley (Brendan M.); S.E. Harris (Sarah); A. Peters (Annette); D. Pulanic (Drazen); T. Lumley (Thomas); A.J.M. de Craen (Anton J.M.); D.C. Liewald (David C.); C. Gieger (Christian); I. Ford (Ian); A.J. Gow (Alan J.); M. Luciano (Michelle); D.J. Porteous (David J.); X. Guo (Xiuqing); N. Sattar (Naveed); A. Tenesa (Albert); M. Cushman (Mary Ann); P.E. Slagboom (Eline); P.M. Visscher (Peter M.); T.D. Spector (Tim); T. Illig (Thomas); I. Rudan (Igor); E.G. Bovill (Edwin G.); A.F. Wright (Alan); W.L. McArdle (Wendy); G.H. Tofler (Geoffrey); A. Hofman (Albert); R.G.J. Westendorp (Rudi); J.M. Starr (John); P.J. Grant (Peter J.); M. Karakas (Mahir); N.D. Hastie (Nicholas D.); B.M. Psaty (Bruce); J.F. Wilson (James); G.D.O. Lowe (Gordon); C.J. O'Donnell (Christopher); J.C.M. Witteman (Jacqueline); J.W. Jukema (Jan Wouter); I.J. Deary (Ian); N. Soranzo (Nicole); W. Koenig (Wolfgang); C. Hayward (Caroline)

    2011-01-01

    textabstractBACKGROUND: Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wi

  6. Changes in fibrin D-dimer, fibrinogen, and protein S during pregnancy

    DEFF Research Database (Denmark)

    Hansen, Anette Tarp; Andreasen, Birgitte Horst; Salvig, Jannie Dalby

    2010-01-01

    Background. Pregnancy is a hypercoagulable state with a 5- to 10- fold higher risk of venous thromboembolism. Existing reference intervals for fibrin D-dimer (D-dimer), functional fibrinogen (fibrinogen) and protein S, free antigen (protein S) are based on non-pregnant patients and reference...... intervals for pregnant patients are warranted. Objectives. The aim of the present study was to contribute to the establishment of reference intervals for D-dimer, fibrinogen and protein S during pregnancy and to discuss the use of the analyses during pregnancy. Methods. We included 55 healthy pregnant women...... in gestational week 11–17, with normal current pregnancy. Blood samples were collected in gestational weeks 11–17, 21–27 and 34–37. The three plasma parameters D-dimer, fibrinogen and protein S were analysed by STA-R Evolution®. Results. A significant rise in D-dimer was found from first to second trimester (p...

  7. Receiver Operating Characteristic (ROC to Determine Cut-Off Points of Biomarkers in Lung Cancer Patients

    Directory of Open Access Journals (Sweden)

    Heidi L. Weiss

    2004-01-01

    Full Text Available The role of biomarkers in disease prognosis continues to be an important investigation in many cancer studies. In order for these biomarkers to have practical application in clinical decision making regarding patient treatment and follow-up, it is common to dichotomize patients into those with low vs. high expression levels. In this study, receiver operating characteristic (ROC curves, area under the curve (AUC of the ROC, sensitivity, specificity, as well as likelihood ratios were calculated to determine levels of growth factor biomarkers that best differentiate lung cancer cases versus control subjects. Selected cut-off points for p185erbB-2 and EGFR membrane appear to have good discriminating power to differentiate control tissues versus uninvolved tissues from patients with lung cancer (AUC = 89% and 90%, respectively; while AUC increased to at least 90% for selected cut-off points for p185erbB-2 membrane, EGFR membrane, and FASE when comparing between control versus carcinoma tissues from lung cancer cases. Using data from control subjects compared to patients with lung cancer, we presented a simple and intuitive approach to determine dichotomized levels of biomarkers and validated the value of these biomarkers as surrogate endpoints for cancer outcome.

  8. Characterization of thermal cut-off mechanisms in prismatic lithium-ion batteries

    Science.gov (United States)

    Venugopal, Ganesh

    Lithium-ion (Li-ion) cells that are subjected to electrical abuse, overcharge and external short-circuit in particular, exhibit a rapid increase in cell temperature that could potentially lead to catastrophic disassembly of the cell. For this reason these cells are integrated or combined with one or more safety components that are designed to restrict or even prevent current flow through the cell under abusive conditions. In this work, the characteristics of these components in several prismatic Li-ion cells are studied by monitoring the impedance ( Z) at 1 kHz and the open circuit voltage (OCV) of the discharged cells as a function of temperature. All the cells studied were found to use polyethylene-based shutdown (SD) separators that were irreversibly activated within a narrow temperature range between 130 and 135°C. In some cells irreversible cut-off was also provided by a current interrupt device (CID) or a thermal fuse. Both these devices had a circuit-breaker effect, causing the impedance of the cell to rise infinitely and the OCV to drop to zero. In addition to these irreversible cut-off mechanisms, some cells also contained internal or external positive-temperature-coefficient (PTC) devices that could provide current-limiting capability over a very wide temperature range. The interdependence of the thermal behavior of these components on each other and on other thermally dependant processes like cell venting, separator meltdown and weld joint failure are also discussed.

  9. Determining a diagnostic cut-off on the Teate Depression Inventory

    Directory of Open Access Journals (Sweden)

    Balsamo M

    2014-06-01

    Full Text Available Michela Balsamo, Aristide SagginoDepartment of Psychological Sciences, Humanities and Territory, G. d’Annunzio University of Chieti-Pescara, Chieti, ItalyAbstract: A small but growing body of literature suggests that the Teate Depression ­Inventory (TDI may be an “objective” measure of depression compared with other commonly used scales. Furthermore, the TDI has strong psychometric properties in both clinical and nonclinical samples. The present study aimed to extend the use of TDI by identifying cut-off scores that could differentiate varying levels of depression severity in a group of clinically diagnosed depression disorder patients (N=125. Three receiver operating characteristic curve analyses indicated cut-off scores of 21 (sensitivity =0.86, specificity =0.94, and classification accuracy =0.90; 36 (sensitivity =0.84, specificity =0.96, and classification accuracy =0.92; and 50 (sensitivity =0.81, specificity =0.93, and classification accuracy =0.90, for minimal, mild, moderate, and severe depression, respectively. Results suggest that the TDI measures depression severity across a broad range with high test accuracy and may be appropriately used to screen for depression.Keywords: major depression, ROC curve, self-report scales, Rasch analysis, depression screening

  10. Cut-Off Values of Visceral Adiposity to Predict NAFLD in Brazilian Obese Adolescents

    Directory of Open Access Journals (Sweden)

    Ana Paula Grotti Clemente

    2013-01-01

    Full Text Available Objectives. The present study aimed at determining cut-off points of visceral fat to predict NAFLD and analyzed metabolic disorders of obese adolescents. Methods. Cross-sectional study involved 165 obese adolescents ranged in age from 15 to 19 years. Glycemia, hepatic transaminases, lipid profile, and insulin resistance were analyzed. Visceral and subcutaneous fat were measured by ultrasound and body composition by plesthysmography. Results. The NAFLD adolescents had significantly higher values for body mass, BMI-for-age, BMI, total fat, waist circumference, and visceral fat when compared with non-NAFLD obese adolescents in both genders. Moreover, there were significant positive correlations between visceral fat with the variables BMI-for-age (r=0.325,, TG (r=0.277, AST (r=0.509, ALT (r=0.519, WC (r=0.390, and visceral/subcutaneous ratio (r=0.790 for NAFLD group. Total fat, triglycerides, and visceral fat were the independent predictors to NAFLD. Analysis of the ROC curves revealed cut-off points of visceral fat of 4.47 cm for girls and 4.21 cm for boys. Conclusions. The results may suggest that abdominal ultrasonography procedure may be a safe alternative method of assessing visceral adiposity aiming to be considered to the development of preventive and treatment strategies in obese individuals. This clinial trial is registered with ClinicalTrial.gov (NCT01358773.

  11. Establishing Streptomycin Epidemiological Cut-Off Values for Salmonella and Escherichia coli

    DEFF Research Database (Denmark)

    Migura, Lourdes Garcia; Sunde, Marianne; Karlsmose, Susanne

    2011-01-01

    This study was conducted to elucidate the accuracy of the current streptomycin epidemiological cut-off value (ECOFF) for Escherichia coli and Salmonella spp. A total of 236 Salmonella enterica and 208 E. coli isolates exhibiting MICs between 4 and 32 mg/L were selected from 12 countries. Isolates...... were investigated by polymerase chain reaction for aadA, strA, and strB streptomycin resistance genes. Out of 236 Salmonella isolates, 32 (13.5%) yielded amplicons for aadA (n = 23), strA (n = 9), and strB (n = 11). None of the 60 Salmonella isolates exhibiting MIC 4 mg/L harbored resistance genes....... Of the Salmonella isolates exhibiting MICs 8 mg/L, 16 mg/L, and 32 mg/L, 1.6%, 15%, and 39%, respectively, tested positive for one or more genes. For most monitoring programs, the streptomycin ECOFF for Salmonella is wild type (WT) ≤32 or ≤16 mg/L. A cut-off value of WT ≤32 mg/L would have misclassified 13...

  12. Proceedings from the Fissile Material Cut-off seminar in Stockholm

    Energy Technology Data Exchange (ETDEWEB)

    Arbman, G. [ed.

    1998-07-01

    The Swedish Defence Research Establishment hosted an international expert seminar on the subject of verifying a prohibition of the production of fissile material for nuclear weapons purpose (cut-off) in Stockholm, June 3-5 1998. The objective of the seminar was to provide an opportunity for informal discussions among scientific and technical experts on various technical matters relating to the verification of a future Fissile Material Cut-off Treaty (FMCT). A stated aim of the seminar was to keep issues of scope to a minimum. Invited speakers and commentators were given an opportunity to present their views as written contributions. The present seminar proceedings are essentially the result of these views. In addition, short summaries of the discussions following each session are included. Although an attempt was made to be as complete and accurate as possible in reproducing these discussions, the editors apologise if some important points or statements have been omitted. If so, the main reason is that the documentation of the discussions were based on written notes, not taped recordings. Eight longer contributions have been separately indexed.

  13. One strategy to enhance electrochemical properties of Ni-based cathode materials under high cut-off voltage for Li-ion batteries

    Science.gov (United States)

    Liang, Longwei; Jiang, Feng; Cao, Yanbing; Hu, Guorong; Du, Ke; Peng, Zhongdong

    2016-10-01

    Well-distributed, nano-sized and amorphous or crystalized NaTi2(PO4)3 (NTP) coating layer with high ionic conductivity is successfully introduced onto the surface of LiNi0.6Co0.2Mn0.2O2 (LNCM) particles by a simple and effective mechanical activation method followed by adjusting the reheating temperature appropriately. The promoting influence of NTP coating on the structure stability, cycle life and high rate capability under elevated cut-off voltage has been investigated in-depth. Particularly for the crystalized NTP-coated LNCM, the main reason for the enhanced electrochemical performance can be attributed to the NTP layer with rhombohedral structure providing convenient and low activation barrier diffusion pathways for Li+ ions to insert/extract the interface of electrode/electrolyte. Besides, the NTP-coated layer with stable structure can effectively inhibit the surface side reaction during the long charge/discharge process under high cut-off voltage, which will reduce the harmful insulative by-products. It's worth mentioning that the cyclic stability of crystalized NTP-coated LNCM between 3.0 and 4.6 V is also improved significantly even under the rigorous test environment.

  14. The Evaluation of Pulmonary Embolism Diagnosis Using SPECT V/Q Imaging Combined with D-Dimer Assay

    Directory of Open Access Journals (Sweden)

    LU Xia;MENG Jing-jing;XIE Xiao-fen;WANG Qian

    2016-11-01

    patients with clinically suspected pulmonary embolism (PE referred to the Nuclear Medicine Department of Beijing Anzhen Hospital from January to July 2014, were enrolled in the study. The patients were divided into PE group (n=101 and non PE group (n=55. We compared the diagnostic performance of SPECT V/Q, D-dimer and SPECT V/Q combined with D-dimer measurement. The SPECT V/Q images were reconstructed by Oasis of Philips and interpreted by the attending nuclear physician using a diagnostic cut-off of one segmental or two subsegmental mismatches. D-dimer had good sensitivity of 70.3% and bad specificity of 61.8% in the 156 patients. SPECT V/Q had good performance both sensitivity (85.1% and specificity (90.9%. But when SPECT V/Q combined with D-dimer, there were best diagnostic sensitivity (91.1% and specificity (98.2% in PE detection, especially in embolization extent less than 15%. SPECT V/Q combined with D-dimer measurement are effective and safe diagnostic management.

  15. The Cut-off Values of Triglycerides and Glucose Index for Metabolic Syndrome in American and Korean Adolescents.

    Science.gov (United States)

    Moon, Shinje; Park, Joon Sung; Ahn, Youhern

    2017-03-01

    The aim of this study was to establish ethnic- and gender-specific cut-off values of triglycerides and glucose index (TyG index) for clinical usefulness in a representative sample of Mexican American, Non-Hispanic White, Non-Hispanic Black, and Korean adolescents. The data were collected from datasets of the National Health and Nutrition Examination Survey between 1999 and 2012, and the Korean National Health and Nutrition Examination Survey between 2005 and 2013. Receiver operating characteristic curve analysis was used to find valid cut-off values of the TyG index for metabolic syndrome. The total number of eligible participants was 3,164 in the US and 4,873 in Korea. The optimal cut-off value with the Cook et al. definition revealed 8.55 in Mexican American, 8.55 in Non-Hispanic White, 8.35 in Non-Hispanic Black, and 8.45 in Korean, respectively. The cut-off value with the de Ferranti et al. definition was 8.45, 8.45, 8.15, and 8.35, and the cut-off value with the International Diabetes Federation definition was 8.65, 8.65, 8.15, and 8.55, respectively. These findings may be clinically useful for evaluating insulin resistance for determining metabolic abnormalities in adolescents.

  16. Cut-off characterisation of energy spectra of bright fermi sources: Current instrument limits and future possibilities

    Science.gov (United States)

    Romoli, C.; Taylor, A. M.; Aharonian, F.

    2017-02-01

    In this paper some of the brightest GeV sources observed by the Fermi-LAT were analysed, focusing on their spectral cut-off region. The sources chosen for this investigation were the brightest blazar flares of 3C 454.3 and 3C 279 and the Vela pulsar with a reanalysis with the latest Fermi-LAT software. For the study of the spectral cut-off we first explored the Vela pulsar spectrum, whose statistics in the time interval of the 3FGL catalog allowed strong constraints to be obtained on the parameters. We subsequently performed a new analysis of the flaring blazar SEDs. For these sources we obtained constraints on the cut-off parameters under the assumption that their underlying spectral distribution is described by a power-law with a stretched exponential cut-off. We then highlighted the significant potential improvements on such constraints by observations with next generation ground based Cherenkov telescopes, represented in our study by the Cherenkov Telescope Array (CTA). Adopting currently available simulations for this future observatory, we demonstrate the considerable improvement in cut-off constraints achievable by observations with this new instrument when compared with that achievable by satellite observations.

  17. Influence of Different Cut-Off Values on the Diagnosis of Mild Cognitive Impairment in Parkinson's Disease

    Directory of Open Access Journals (Sweden)

    Inga Liepelt-Scarfone

    2011-01-01

    Full Text Available Comparable to Alzheimer's disease, mild cognitive impairment in Parkinson's disease (PD-MCI is associated with an increased risk for dementia. However different definitions of PD-MCI may have varying predictive accuracy for dementia. In a cohort of 101 nondemented Parkinson patients who underwent neuropsychological testing, the frequency of PD-MCI subjects and PD-MCI subtypes (i.e., amnestic/nonamnestic was determined by use of varying healthy population-based cut-off values. We also investigated the association between defined PD-MCI groups and ADL scales. Varying cut-off values for the definition of PD-MCI were found to affect frequency of PD-MCI subjects (9.9%–92.1% and, maybe more important, lead to a “shift” of proportion of detected PD-MCI subtypes especially within the amnestic single-domain subtype. Models using a strict cut-off value were significantly associated with lower ADL scores. Thus, the use of defined cut-off values for the definition of PD-MCI is highly relevant for comparison purposes. Strict cut-off values may have a higher predictive value for dementia.

  18. [Negative D-dimers and exclusion of venous thromboembolism--own experience].

    Science.gov (United States)

    Dworakowska, Dorota; Kazimierska, Ewa; Weyer-Hepka, Jolanta; Skibowska-Bielińska, Anna; Swiatkowska-Stodulska, Renata; Lubińska, Monika; Czestochowska, Eugenia

    2005-12-01

    The assessment of D-dimer concentration has become essential step during diagnostic algorithm of venous thromboembolism (VTE). This test characterizes high sensitivity but limited specificity. Negative D-dimer with high probability excludes VTE. The aim of this study was to assess the percentage of patients treated in Department of Internal Medicine, Endocrinology and Haemostatic Disorders, Medical University of Gdańisk, who in spite of clinical signs of VTE showed normal D-dimer level. Between 2000 and 2004 in our department 57 cases with recent deep vein thrombosis (DVT) were diagnosed, in 2 cases with co-existence of pulmonary embolism (PE). The D-dimer concentration was assessed in patients' plasma with the use of immunoturbidometry. Between 57 cases with VTE, 7 patients (12%) showed normal D-dimer level (<500 microg/ml). This group consisted of 4 men and 3 women, aged from 40 to 82 years (the mean age of 58 years). In all 7 cases DVT was diagnosed, in 2 patients with concomitent PE. The final diagnosis was confirmed by compression ultrasonography and pulmonary scintigraphy. Our analysis underlines the observation that occurrence of VTE and negative d-dimer concentration is possible and may probably be related to methodological limitations. However, the lack of increase of D-dimer could also be caused by fibrinolysis alteration.

  19. Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories

    Directory of Open Access Journals (Sweden)

    G. Der Sahakian

    2010-01-01

    Full Text Available Background. Strategies combining pretest clinical assessment and D-dimers measurement efficiently and safely rule out venous thromboembolism events (VTE in low- and intermediate-risk patients. Objectives. As process of ageing is associated with altered concentrations of coagulation markers including an increase in D-dimers levels, we investigated whether D-dimers could reliably rule out VTE across age categories. Method. We prospectively assessed the test performance in 1,004 patients visiting the emergency department during the 6-month period with low or intermediate risk of VTE who also received additional diagnostic procedures. Results. 67 patients had VTE with D-dimers levels above the threshold, and 3 patients displayed D-dimers levels below the threshold. We observed that specificity of D-dimers test decreased in an age-dependent manner. However, sensitivity and negative predictive value remained at very high level in each age category including older patients. Conclusion. We conclude that, even though D-dimers level could provide numerous false positive results in elderly patients, its high sensitivity could reliably help physicians to exclude the diagnosis of VTE in every low- and intermediate-risk patient.

  20. Why did Van Gogh cut off his ear? The problem of alternative explanations in psychobiography.

    Science.gov (United States)

    Runyan, W M

    1981-06-01

    One of the tasks of personality psychology is to explain the behavior of individual human beings. Vincent Van Gogh, for example, cut off the lower half of his left ear and gave it to a prostitute. More than a dozen different explanations of his actions have been proposed. Is one of these explanations true, are all of them true, or, perhaps, are none of them true? And how can we know? This incident is examined in order to explore some of the problems in applying personality theories to the life of a single individual. A sequential procedure for generating and critically evaluating alternative explanatory conjectures is presented a a partial, although not a complete, solution to the problem of multiple interpretations.

  1. Percentile curves for body fatness and cut-offs to define malnutrition in Russians

    Science.gov (United States)

    Nikolaev, D. V.; Rudnev, S. G.; Starunova, O. A.; Eryukova, T. A.; Kolesnikov, V. A.; Ponomareva, E. G.; Soboleva, N. P.; Sterlikov, S. A.

    2013-04-01

    Here, we report first results of the large-scale ongoing bioelectrical impedance body composition study in Russians. By the end of 2012, 216 out of 800 Russian Health Centres submitted raw bioimpedance data on 844,221 adults and children aged 5-80 years, representing nearly 0.6% of the Russian population, who were accessed cross-sectionally using the same type of bioimpedance meter, ABC-01 Medas. Estimates of overweight, obesity, and normal weight obesity prevalence in the general population, as well as characteristics of diagnostic sensitivity and specificity of the conventional WHO BMI-based criteria of obesity depending on age are obtained. The smoothed reference centile curves for percentage fat mass are constructed, and localized cut-offs for fatness and thinness are provided that can be used both at the individual and epidemiological levels.

  2. The Warm DM halo mass function below the cut-off scale

    CERN Document Server

    Angulo, Raul E; Abel, Tom

    2013-01-01

    Warm Dark Matter (WDM) cosmologies are a viable alternative to the Cold Dark Matter (CDM) scenario. Unfortunately, an accurate scrutiny of the WDM predictions with N-body simulations has proven difficult due to numerical artifacts. Here, we report on cosmological simulations that, for the first time, are devoid of those problems, and thus, are able to accurately resolve the WDM halo mass function well below the cut-off. We discover a complex picture, with perturbations at different evolutionary stages populating different ranges in the halo mass function. On the smallest mass scales we can resolve, identified objects are typically centres of filaments that are starting to collapse. On intermediate mass scales, objects typically correspond to fluctuations that have collapsed and are in the process of relaxation, whereas the high mass end is dominated by objects similar to haloes identified in CDM simulations. When explicitly show how the formation of low-mass haloes is suppressed, which translates into a stron...

  3. The puzzle about the radial cut-off in galactic disks

    CERN Document Server

    Narayan, C A; Narayan, Chaitra A.; Jog, Chanda J.

    2003-01-01

    The stellar disk in a spiral galaxy is believed to be truncated physically because the disk surface brightness is observed to fall faster than that for an exponential in the outer, faint regions. We review the literature associated with this phenomenon and find that a number of recent observations contradict the truncation picture. Hence we question the very existence of a physical outer cut-off in stellar disks. We show, in this paper, that the observed drop in the surface brightness profiles in fact corresponds to a negligible decrease in intensity, and that this minor change at the faint end appears to be exaggerated on a log-normal plot. Since minor deviations from a perfect exponential are common throughout the disk, we suggest that such a deviation at the faint end could easily give rise to the observed sharp drop.

  4. From Newton's Law to the Linear Boltzmann Equation Without Cut-Off

    Science.gov (United States)

    Ayi, Nathalie

    2017-01-01

    We provide a rigorous derivation of the linear Boltzmann equation without cut-off starting from a system of particles interacting via a potential with infinite range as the number of particles N goes to infinity under the Boltzmann-Grad scaling. More particularly, we will describe the motion of a tagged particle in a gas close to global equilibrium. The main difficulty in our context is that, due to the infinite range of the potential, a non-integrable singularity appears in the angular collision kernel, making no longer valid the single-use of Lanford's strategy. Our proof relies then on a combination of Lanford's strategy, of tools developed recently by Bodineau, Gallagher and Saint-Raymond to study the collision process, and of new duality arguments to study the additional terms associated with the long-range interaction, leading to some explicit weak estimates.

  5. From Newton's Law to the Linear Boltzmann Equation Without Cut-Off

    Science.gov (United States)

    Ayi, Nathalie

    2017-03-01

    We provide a rigorous derivation of the linear Boltzmann equation without cut-off starting from a system of particles interacting via a potential with infinite range as the number of particles N goes to infinity under the Boltzmann-Grad scaling. More particularly, we will describe the motion of a tagged particle in a gas close to global equilibrium. The main difficulty in our context is that, due to the infinite range of the potential, a non-integrable singularity appears in the angular collision kernel, making no longer valid the single-use of Lanford's strategy. Our proof relies then on a combination of Lanford's strategy, of tools developed recently by Bodineau, Gallagher and Saint-Raymond to study the collision process, and of new duality arguments to study the additional terms associated with the long-range interaction, leading to some explicit weak estimates.

  6. Estimation of cut-off wavelength of rare earth doped single-mode fibers

    Science.gov (United States)

    Kaur, Jagneet; Thyagarajan, K.; Pal, B. P.

    1999-11-01

    A new empirical relation is proposed describing spectral variation of mode-field radius (MFR) as inferred from measurements in the far-field of the fiber. It is shown that using this relation, it is possible to estimate the cut-off wavelength ( λc) of the fiber. The proposed technique is successfully tested through measurements made on two standard step index single-mode fibers, as well as on an erbium doped fiber (EDF) having λc falling within its strong absorption band around 980 nm. This empirical formula is more accurate than the widely used Marcuse's formula to describe spectral dependence of MFR determined through measurements made in the fiber's far-field. The proposed technique is especially suited for estimation of λc of doped fibers in which λc falls within an absorption band.

  7. Refining Game Addiction Questionnairs: Evidence for a natural cut-off point?

    DEFF Research Database (Denmark)

    Nielsen, Rune Kristian

    2013-01-01

    This paper presents data from a pilot study, which was designed to illuminate critical flaws in the currently used instruments used to measure the prevalence of ‘computer game addiction’. The study found that the prevalence rate could be set anywhere between 23% and 0,6% depending on how the data......’ from ‘addicted gamers’ by making implicit assumptions about negative effects explicit will cause prevalence rates to drop even further. Unexpectedly, the data from this modified questionnaire provides preliminary evidence for a natural cut-off point that clearly separates addicted play from normal play...... is unique in the field of prevalence studies of computer game addiction both in its design and its findings. The findings and conclusions need to be addressed by future research in the area....

  8. Evaluation of D-dimer test in patients on chronic hemodialysis

    Directory of Open Access Journals (Sweden)

    Vurusic Branimir

    2013-07-01

    Full Text Available Determining the value of D-Dimer is a routine test in case of suspecting thromboembolic event. In patients on chronic dialysis, baseline concentrations for biomarkers have changed in widespread clinical use, which prompted us to measure the concentration of D-dimer, due to disorders of hemostasis in chronic kidney failure. From the evaluation of the findings of D-dimer in 67 patients and the available literature we can conclude that the value of the test in the diagnosis of thromboembolic events has significantly decreased.

  9. Factors associated with D-dimer levels in HIV-infected individuals

    DEFF Research Database (Denmark)

    Borges, Alvaro H; O'Connor, Jemma L; Phillips, Andrew N;

    2014-01-01

    [IL-6]), antiretroviral therapy (ART) use, ART regimens, co-morbidities (hepatitis B/C, diabetes mellitus, prior cardiovascular disease), smoking, renal function (estimated glomerular filtration rate [eGFR] and cystatin C) and cholesterol. RESULTS: Women from all age groups had higher D-dimer levels...... viruses, was positively correlated with D-dimer. Other factors independently associated with higher D-dimer levels were black race, higher plasma HIV RNA levels, being off ART at baseline, and increased levels of CRP, IL-6 and cystatin C. In contrast, higher baseline CD4+ counts and higher high...

  10. D-dimer is useful in assessing the vulnerable blood in elderly patients with coronary disease

    Institute of Scientific and Technical Information of China (English)

    Yansong Zheng; Qiang Zeng; Liping Zhang; Liufa Duan; Kunlun He; Qiufu Zheng

    2008-01-01

    Background and objective The value of D-dimer in the risk stratification of patients with coronary artery diseas(CAD)and the relationship between D-dimer and the diseased coronary arteries remains controversial or unclear.especially in the elderly.Thisstudy was to evaluate the usefulness of D-djmer as a biomarker in assessing the vuinerable blood in the elderly patients with coronarydisease.Methods Sixty elderly (≥60 years old)male patients with suspected CAD were enrolled in this prospective study.Patients were divided into CAD group(n=41,10 with stable angina and 31 with unstable angina)and control group(n=19)according to their coronary angiography Results Clinicalinformation including age,body mass index(BMI),smoking index,and thecomplications of Primary hypertension or diabetes.and CAD family history was collected.Venous blood was sampled serially for thedetermination of total cholesterol,HDL cholesterol,LDL cholesterol,triglycerides,apoAl,apoB,glucose,uric acid,homocysteine(Hey),hs-CRP,soluble thrombomodulin(sTM),and marker of fibrinolytic system and hypercoagulability,such as D-dimer,fibrinogen,etc.The extent of coronary atherosclerosis was assessed.using the Gensini scoring system on the basis of coronary angiography.Results Compared with the controls.the patients with CAD had significantly higher levels of D-dimer.D-dimer level wassignificantly correlated to age.hs-CR P.Hcy,and PAI-1.Patients with D-dimer levels in the top triplicate of D-dimer level hadsignificantly higher prevalence of unstable angina compared with patients in the lowest triplicate(OR=4.8,Z=3.28,P=0.001).In anordinal logistic regression.the OR value ofdeveloping more serious CAD augmented 3.1-foid with each increasing triplicate of D-dimer.Patients with unstable angina had a significantly higher level of D-dimer than the controls(P=0.005),and an increasing trend comparedwith patients with stable angina (P=0.059).whereas there was no difference between the patients with stable angina and

  11. Diagnostic Accuracy of a New d-Dimer Assay (Sclavo Auto d-Dimer) for Exclusion of Deep Vein Thrombosis in Symptomatic Outpatients.

    Science.gov (United States)

    Legnani, Cristina; Cini, Michela; Frascaro, Mirella; Rodorigo, Giuseppina; Sartori, Michelangelo; Cosmi, Benilde

    2017-04-01

    In patients presenting non-high clinical pretest probability (PTP), a negative d-dimer can exclude venous thromboembolism without imaging tests. However, each d-dimer assay should be validated in prospective studies. We evaluated an automated d-dimer immunoassay using the Sclavo Auto d-dimer (Sclavo Diagnostics Int, Sovicille, Italy) provided by Dasit Diagnostica (Cornaredo, Milan, Italy). Three hundred two consecutive outpatients suspected of leg deep vein thrombosis (DVT) with non-high PTP were included. The Sclavo Auto d-dimer assay was evaluated on 2 analyzers (Sysmex CA-7000 and Sysmex CS-2100; Sysmex Corporation, Kobe, Japan, provided by Dasit). The cutoff value (200 ng/mL) was established a priori. Prevalence of DVT was 11.9%. Since no false-negative patients were detected, the sensitivity and negative predictive values (NPVs) were 100% (sensitivity = CA-7000: 100% [95% confidence interval, CI: 93.3-100], CS-2100: 100% [95% CI: 93.3-100]; NPV = CA-7000: 100% [95% CI: 97.9-100], CS-2100: 100% [95% CI: 98.0-100]). Specificity was 65.4% (95% CI: 59.4-71.1) and 69.2% (95% CI: 63.3-74.7) for CA-7000 and CS-2100, respectively. Specificity increased when a higher cutoff value (234 ng/mL) was used for patients aged ≥60 years without compromising the safety. Assay reproducibility was satisfactory at concentrations near the cutoff value (total coefficient of variations d-dimer assay was accurate when used for DVT diagnostic workup in outpatients with non-high PTP. Based on its high sensitivity and NPV, it can be used as a stand-alone test in outpatients with non-high PTP. Given its high specificity, the number of patients in whom further imaging techniques can be avoided increased, improving the yield of the test.

  12. Role of neutron and proton system in spin cut off parameter and entropy of {sup 89,90}Y

    Energy Technology Data Exchange (ETDEWEB)

    Rahmatinejad, A. [Department of Physics, Faculty of Science, University of Zanjan, Zanjan (Iran, Islamic Republic of); Razavi, R., E-mail: rrazavin@ihu.ac.ir [Physics Department, Faculty of Science, Imam Hossein Comprehensive University, Tehran (Iran, Islamic Republic of); Kakavand, T. [Department of Physics, Faculty of Science, Imam Khomeini International University, Qazvin (Iran, Islamic Republic of)

    2015-09-15

    The nuclear level densities, entropies and spin cut off parameters have been determined in {sup 89,90}Y nuclei using the BCS model with inclusion of pairing interaction. The results have a good agreement with the recent experimental data on the level densities measured by the Oslo group. In addition, the entropy excess of {sup 90}Y compared to {sup 89}Y as a function of temperature has been extracted. Also, the role of neutron and proton systems in the entropy excess as well as the spin cut off excess have been investigated using the entropy excess ratio and spin cut off excess ratio introduced in our previous publication. The role of the neutron system at low temperatures, the temperatures below critical temperature, in the semi-magic nucleus {sup 89}Y is similar compared to the closed shell proton system in the tin isotopes.

  13. Role of neutron and proton system in spin cut off parameter and entropy of 89,90Y

    Science.gov (United States)

    Rahmatinejad, A.; Razavi, R.; Kakavand, T.

    2015-09-01

    The nuclear level densities, entropies and spin cut off parameters have been determined in 89,90Y nuclei using the BCS model with inclusion of pairing interaction. The results have a good agreement with the recent experimental data on the level densities measured by the Oslo group. In addition, the entropy excess of 90Y compared to 89Y as a function of temperature has been extracted. Also, the role of neutron and proton systems in the entropy excess as well as the spin cut off excess have been investigated using the entropy excess ratio and spin cut off excess ratio introduced in our previous publication. The role of the neutron system at low temperatures, the temperatures below critical temperature, in the semi-magic nucleus 89Y is similar compared to the closed shell proton system in the tin isotopes.

  14. Cut-off point for WHOQOL-bref as a measure of quality of life of older adults.

    Science.gov (United States)

    Silva, Patrícia Aparecida Barbosa; Soares, Sônia Maria; Santos, Joseph Fabiano Guimarães; Silva, Líliam Barbosa

    2014-06-01

    OBJECTIVE To propose a cut-off for the World Health Organization Quality of Life-Bref (WHOQOL-bref) as a predictor of quality of life in older adults.METHODS Cross-sectional study with 391 older adults registered in the Northwest Health District in Belo Horizonte, MG, Southeastern Brazil, between October 8, 2010 and May 23, 2011. The older adults' quality of life was measured using the WHOQOL-bref. The analysis was rationalized by outlining two extreme and simultaneous groups according to perceived quality of life and satisfaction with health (quality of life good/satisfactory - good or very good self-reported quality of life and being satisfied or very satisfied with health - G5; and poor/very poor quality of life - poor or very poor self-reported quality of life and feeling dissatisfied or very dissatisfied with health - G6). A Receiver-Operating Characteristic curve (ROC) was created to assess the diagnostic ability of different cut-off points of the WHOQOL-bref.RESULTS ROC curve analysis indicated a critical value 60 as the optimal cut-off point for assessing perceived quality of life and satisfaction with health. The area under the curve was 0.758, with a sensitivity of 76.8% and specificity of 63.8% for a cut-off of ≥ 60 for overall quality of life (G5) and sensitivity 95.0% and specificity of 54.4% for a cut-off of < 60 for overall quality of life (G6).CONCLUSIONS Diagnostic interpretation of the ROC curve revealed that cut-off < 60 for overall quality of life obtained excellent sensitivity and negative predictive value for tracking older adults with probable worse quality of life and dissatisfied with health.

  15. Establishing New Cut-Off Limits for Galactose 1-Phosphate-Uridyltransferase Deficiency for the Dutch Newborn Screening Programme.

    Science.gov (United States)

    Kemper, E A; Boelen, A; Bosch, A M; van Veen-Sijne, M; van Rijswijk, C N; Bouva, M J; Fingerhut, R; Schielen, P C J I

    2016-05-21

    Newborn screening for classical galactosemia in the Netherlands is performed by five laboratories and is based on the measurement of galactose 1-phosphate-uridyltransferase (GALT) activity and total galactose (TGAL) in heel prick blood spots. Unexpected problems with the GALT assay posed a challenge to switch to a new assay. The aim of this study was to make an analytical and clinical evaluation of GALT assays to replace the current assay and to establish new cut-off values (COVs).First, the manual assay from PerkinElmer (NG-1100) and the GSP assay were compared by analyzing 626 anonymous heel prick samples in parallel. Secondly, a manual GSP method was evaluated and 2,052 samples were compared with the automated GSP assay. Finally, a clinical evaluation was performed by collecting data from 93 referred newborns.No satisfactory correlation was observed between GALT activity measured with the manual NG-1100 assay and the automated GSP assay. An acceptable correlation was found between the manual and automated GSP assay. Intra- and inter-assay variation of the automated GSP were 1.8-10.0% and 3.1-13.9%, respectively. Evaluation of clinical data demonstrated that adjusting the COVs for GALT to 2.0 U/dl and TGAL to 1,100 μmol/l improved specificity of screening for classical galactosemia.An assay designed for automated processing to measure GALT activity in heel prick samples works equally well when processed manually. We therefore adopted both methods in the Dutch screening laboratories. As a result of this evaluation new COVs for GALT and TGAL have been introduced and are valid from July 2015.

  16. Approach to realize sharp cut-off characteristics multi-ring optical filters; Fukugo ringu kyoshin koha fuiruta no shadan tokusei no kyushunka ni taisuru kento

    Energy Technology Data Exchange (ETDEWEB)

    Furuta, Hirosuke; Tsuruta, Ken' ichi; Miyamoto, Tokuo

    1999-03-01

    Recently, optical filters for wavelength division multiplexing (WDM) systems has been very intensively investigated. However, the report on improved cut-off characteristics is very few. For this reason, we tried to improve cut-off characteristics of filters adding feedback route to the ring resonators. Very sharp cut-off characteristics are obtained. But the attenuation loss become down. It may be very effective to improve the cut-off characteristics of filters to adding a new feedback route to the resonators but some new measurements must be necessary to keep the high stop band loss. (author)

  17. Anthropometric parameters’ cut-off points and predictive value for metabolic syndrome in women from Cartagena, Colombia

    Directory of Open Access Journals (Sweden)

    Gustavo José Mora-García

    2014-03-01

    Full Text Available Objective. To estimate anthropometric parameters’ (APs cut-off points and association for metabolic syndrome (MetS. Materials and methods. A cross-sectional study was carried out with a total of 434 adult women from Cartagena de Indias, Colombia, in 2012. APs measured were waist circumference (WC, body mass index (BMI, body adiposity index (BAI, waist-hip ratio (WHR and waist-height ratio (WHtR. Cut-off points were estimated by a receiver operating characteristic curve (ROC. Logistic regression was applied to estimate possible associations. Results. Cut-off points for WC, BMI, BAI, WHR and WHtR were 85 cm, 28 kg/m2, 39%, 0.80 and 56, respectively. Only WHtR was associated to MetS (OR=1.11, CI95% [1.07-1.15]. Conclusion. WC cut-off point was higher than those proposed for Latin-American women by the Joint Interim Statement (JIS. WHtR had a low predictive value for MetS.

  18. Quantum fields and Poisson processes: interaction of a cut-off boson field with a quantum particle

    Energy Technology Data Exchange (ETDEWEB)

    Bertrand, J.; Rideau, G.; Gaveau, B.

    1985-01-01

    The solution of the Schroedinger equation for a boson field interacting with a quantum particle is written as an expectation on a Poisson process counting the variations of the boson-occupation numbers for each momentum. An energy cut-off is needed for the expectation to be meaningful.

  19. Quantum fields and poisson processes: Interaction of a cut-off boson field with a quantum particle

    Science.gov (United States)

    Bertrand, Jacqueline; Gaveau, Bernard; Rideau, Guy

    1985-01-01

    The solution of the Schrödinger equation for a boson field interacting with a quantum particle is written as an expectation on a Poisson process counting the variations of the boson-occupation numbers for each momentum. An energy cut-off is needed for the expectation to be meaningful.

  20. Flexible Lab-Tailored Cut-Offs for Suitability of Formalin-Fixed Tumor Samples for Diagnostic Mutational Analyses

    Science.gov (United States)

    Mariani, Sara; Tondat, Fabrizio; Pacchioni, Donatella; Molinaro, Luca; Barreca, Antonella; Macrì, Luigia; Chiusa, Luigi; di Celle, Paola Francia; Cassoni, Paola; Sapino, Anna

    2015-01-01

    The selection of proper tissues from formalin-fixed and paraffin-embedded tumors before diagnostic molecular testing is responsibility of the pathologist and represents a crucial step to produce reliable test results. The international guidelines suggest two cut-offs, one for the percentage and one for the number of tumor cells, in order to enrich the tumor content before DNA extraction. The aim of the present work was two-fold: to evaluate to what extent a low percentage or absolute number of tumor cells can be qualified for somatic mutation testing; and to determine how assay sensitivities can guide pathologists towards a better definition of morphology-based adequacy cut-offs. We tested 1797 tumor specimens from melanomas, colorectal and lung adenocarcinomas. Respectively, their BRAF, K-RAS and EGFR genes were analyzed at specific exons by mutation-enriched PCR, pyrosequencing, direct sequencing and real-time PCR methods. We demonstrate that poorly cellular specimens do not modify the frequency distribution of either mutated or wild-type DNA samples nor that of specific mutations. This observation suggests that currently recommended cut-offs for adequacy of specimens to be processed for molecular assays seem to be too much stringent in a laboratory context that performs highly sensitive routine analytical methods. In conclusion, new cut-offs are needed based on test sensitivities and documented tumor heterogeneity. PMID:25844806

  1. Intense, Narrow-band THz Emission from a Current Source Immersed in Cut-off of Plasma-like Media

    Science.gov (United States)

    Hur, Min Sup; Ersfeld, Bernhard; Noble, Adam; Suk, Hyyong; Jaroszynski, Dino

    2016-10-01

    Recently we found an interesting behavior of the electromagnetic radiation emerging from cut-off condition of a plasma-like medium, when it is driven by a current source. Differently from conventional total reflection of the incident wave at the cut-off, we found a spatially diffusing and temporally growing electromagnetic field from the current source. Direct result of such diffusion-growth is the selectively enhanced emission (SEE) at the cut-off frequency from a generally broadband current oscillation. We demonstrate examples demonstrating the SEE. One is the two-color-driven THz emission from field ionization of the gas slab located in a tapered waveguide. The emission propagating through the waveguide exhibits a significantly enhanced spectral density at the cut-off frequency. The other example is the THz emission from a magnetized plasma driven by two colliding ultra-short laser pulses. Since a very narrow-band emission can be selectively enhanced from a broadband radiation source, the SEE concept can be used for conversion of a general broadband THz source to a narrow-band one by locating it in a meta-structure such as the waveguide or a plasma-like medium. We discuss other possible systems to which SEE can be applied.

  2. Cut-off Characterisation of Energy Spectra of Bright Fermi Sources: Current instrument limits and future possibilities

    CERN Document Server

    Romoli, C; Aharonian, F

    2016-01-01

    In this paper some of the brightest GeV sources observed by the Fermi-LAT were analysed, focusing on their spectral cut-off region. The sources chosen for this investigation were the brightest blazar flares of 3C 454.3 and 3C 279 and the Vela pulsar using catalogue data and reanalysis with the latest Fermi-LAT software. For the study the spectral cut-off we first explored the Vela pulsar spectrum, whose statistics in the 3FGL catalog allowed strong constraints to be obtained on the parameters. We subsequently performed a new analysis of the flaring blazar SEDs. For these sources we obtained constraints on the cut-off parameters under the assumption that their underlying spectral distribution is described by a power-law with a stretched exponential cut-off. We then highlighted the significant potential improvements on such constraints by observations with next generation ground based Cherenkov telescopes, represented in our study by the Cherenkov Telescope Array (CTA). Adopting currently available simulations ...

  3. Cut-off levels and diagnostic accuracy of infliximab trough levels and anti-infliximab antibodies in Crohn's disease

    DEFF Research Database (Denmark)

    Steenholdt, Casper; Bendtzen, Klaus; Brynskov, Jørn

    2011-01-01

    Reasons for infliximab failure in Crohn's disease and ulcerative colitis are debated. Serum levels of infliximab and anti-infliximab antibodies have been associated with loss of response. We aimed at determining cut-off levels for infliximab and anti-infliximab antibody concentrations associated...

  4. ELISA Cut-off Point for the Diagnosis of Human Brucellosis; a Comparison with Serum Agglutination Test

    Directory of Open Access Journals (Sweden)

    Anahita Sanaei Dashti

    2012-03-01

    Full Text Available Background: Brucellosis is a world-wide disease, which has a diverse clinical manifestation, and its diagnosis has to be proven by laboratory data. Serum agglutination test (SAT is the most-widely used test for diagnosing brucellosis. The enzyme linked immunosorbent assay (ELISA can also determine specific antibody classes against brucella. It is a sensitive, simple and rapid test, which could be an acceptable alternative to SAT with fewer limitations, however, like any other new test it should be further evaluated and standardized for various populations. This study was planned to determine an optimal cut-off point, for ELISA which would offer maximum sensitivity and specificity for the test when compared to SAT.Methods: Four hundred and seven patients with fever and other compatible symptoms of brucellosis were enrolled in the study. Serum agglutination test, 2-Mercaptoethanol test, and ELISA were performed on their sera. Results: The cut-off point of 53 IU/ml of ELISA-IgG yielded the maximal sensitivity and specificity comparing to the other levels of ELISA-IgG, and was considered the best cut off-point of ELISA-IgG to diagnose acute brucellosis. At this cut-off, the sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio were 84.09%, 85.38%, 62.20, 94.90, 5.75, 0.18, respectively.Conclusion: The best cut-off point of ELISA-IgG is 53 IU/ml, which yields the maximal sensitivity and specificity to diagnose acute brucellosis.

  5. Extended characterization of a new class of membranes for blood purification: the high cut-off membranes.

    Science.gov (United States)

    Boschetti-de-Fierro, Adriana; Voigt, Manuel; Storr, Markus; Krause, Bernd

    2013-07-01

    High cut-off membranes are a new class of blood purification membranes whose particular characteristics present challenges for commonly-used characterization methods. Dextran sieving curves for representative blood purification membranes of the high-flux and high cut-off types were measured and compared to curves for the glomerular filtration barrier (GFB). The performance was also determined after blood exposure for the most permeable synthetic membranes. High cut-off membranes were observed to be more open than the GFB before blood exposure, but become tighter and more selective after the exposure, keeping the permeation for low and middle molecules while restraining the filtration of large species. Based on dextran sieving experiments for a variety of commercially available blood purification membranes, we present a novel method for classifying blood purification membranes. By using a well-established technique and introducing a new characteristic parameter for the sieving curve--the molecular weight retention onset (MWRO)--a graph of molecular weight cut-off versus molecular weight retention onset provides the landscape of dialysis membrane types. This meaningful representation is based on only one in vitro method, and allows the membrane classification by indirectly considering two structural parameters: pore size and pore size distribution. In this way, the families of low-flux, high-flux, protein leaking, and high cut-off membranes are clearly differentiated. The differentiation allows for the definition of MWCO/MWRO regions for the different types, so that further classification of newly developed membranes can be easily achieved.

  6. Fast Modeling of Large Wave Energy Farms Using Interaction Distance Cut-Off

    Directory of Open Access Journals (Sweden)

    Malin Göteman

    2015-12-01

    Full Text Available In many wave energy concepts, power output in the MW range requires the simultaneous operation of many wave energy converters. In particular, this is true for small point-absorbers, where a wave energy farm may contain several hundred devices. The total performance of the farm is affected by the hydrodynamic interactions between the individual devices, and reliable tools that can model full farms are needed to study power output and find optimal design parameters. This paper presents a novel method to model the hydrodynamic interactions and power output of very large wave energy farms. The method is based on analytical multiple scattering theory and uses time series of irregular wave amplitudes to compute the instantaneous power of each device. An interaction distance cut-off is introduced to improve the computational cost with acceptable accuracy. As an application of the method, wave energy farms with over 100 devices are studied in the MW range using one month of wave data measured at an off-shore site.

  7. Susceptibility profile and epidemiological cut-off values of Cryptococcus neoformans species complex from Argentina.

    Science.gov (United States)

    Córdoba, Susana; Isla, Maria G; Szusz, Wanda; Vivot, Walter; Altamirano, Rodrigo; Davel, Graciela

    2016-06-01

    Epidemiological cut-off values (ECVs) based on minimal inhibitory concentration (MIC) distribution have been recently proposed for some antifungal drug/Cryptococcus neoformans combinations. However, these ECVs vary according to the species studied, being serotypes and the geographical origin of strains, variables to be considered. The aims were to define the wild-type (WT) population of the C. neoformans species complex (C. neoformans) isolated from patients living in Argentina, and to propose ECVs for six antifungal drugs. A total of 707 unique C. neoformans isolates obtained from HIV patients suffering cryptococcal meningitis were studied. The MIC of amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole and posaconazole was determined according to the EDef 7.2 (EUCAST) reference document. The MIC distribution, MIC50 , MIC90 and ECV for each of these drugs were calculated. The highest ECV, which included ≥95% of the WT population modelled, was observed for flucytosine and fluconazole (32 μg ml(-1) each). For amphotericin B, itraconazole, voriconazole and posaconazole, the ECVs were: 0.5, 0.5, 0.5 and 0.06 μg ml(-1) respectively. The ECVs determined in this study may aid in identifying the C. neoformans strains circulating in Argentina with decreased susceptibility to the antifungal drugs tested.

  8. Detection of cut-off point for rapid automized naming test in good readers and dyslexics

    Directory of Open Access Journals (Sweden)

    Zahra Soleymani

    2014-01-01

    Full Text Available Background and Aim: Rapid automized naming test is an appropriate tool to diagnose learning disability even before teaching reading. This study aimed to detect the cut-off point of this test for good readers and dyslexics.Methods: The test has 4 parts including: objects, colors, numbers and letters. 5 items are repeated on cards randomly for 10 times. Children were asked to name items rapidly. We studied 18 dyslexic students and 18 age-matched good readers between 7 and 8 years of age at second and third grades of elementary school; they were recruited by non-randomize sampling into 2 groups: children with developmental dyslexia from learning disabilities centers with mean age of 100 months, and normal children with mean age of 107 months from general schools in Tehran. Good readers selected from the same class of dyslexics.Results: The area under the receiver operating characteristic curve was 0.849 for letter naming, 0.892 for color naming, 0.971 for number naming, 0.887 for picture naming, and 0.965 totally. The overall sensitivity and specificity was 1 and was 0.79, respectively. The highest sensitivity and specificity were related to number naming (1 and 0.90, respectively.Conclusion: Findings showed that the rapid automized naming test could diagnose good readers from dyslexics appropriately.

  9. Accuracy of Cameriere's cut-off value for third molar in assessing 18 years of age.

    Science.gov (United States)

    De Luca, S; Biagi, R; Begnoni, G; Farronato, G; Cingolani, M; Merelli, V; Ferrante, L; Cameriere, R

    2014-02-01

    Due to increasingly numerous international migrations, estimating the age of unaccompanied minors is becoming of enormous significance for forensic professionals who are required to deliver expert opinions. The third molar tooth is one of the few anatomical sites available for estimating the age of individuals in late adolescence. This study verifies the accuracy of Cameriere's cut-off value of the third molar index (I3M) in assessing 18 years of age. For this purpose, a sample of orthopantomographs (OPTs) of 397 living subjects aged between 13 and 22 years (192 female and 205 male) was analyzed. Age distribution gradually decreases as I3M increases in both males and females. The results show that the sensitivity of the test was 86.6%, with a 95% confidence interval of (80.8%, 91.1%), and its specificity was 95.7%, with a 95% confidence interval of (92.1%, 98%). The proportion of correctly classified individuals was 91.4%. Estimated post-test probability, p was 95.6%, with a 95% confidence interval of (92%, 98%). Hence, the probability that a subject positive on the test (i.e., I3Mage or older was 95.6%.

  10. Holographic Dark Energy Model with Hubble Horizon as an IR Cut-off

    CERN Document Server

    Xu, Lixin

    2009-01-01

    The main task of this paper is to realize a cosmic observational compatible present accelerated expansion and past decelerated expansion universe in the framework of holographic dark energy model when the Hubble horizon $H$ as an IR cut-off. When the model parameter $c$ of time variable cosmological constant (CC) $\\Lambda(t)=3c^{2}H^{2}(t)$ becomes time or scale dependent, another extra term is gained in the effective equation of sate (EoS) of the vacuum energy $w^{eff}_{\\Lambda}=-c^2-d\\ln c^{2}/3d\\ln a$. This extra term can make the effective EoS of time variable CC cross the cosmological boundary and phantom-like at present. For the lack of a first principle and fundamental physics theory to obtain the form $c^2$, we give a simple parameterized $c^2$ as an example which is confronted by the cosmic observations including SN Ia, BAO and CMB shift parameter $R$. The result shows that the model is consistent with cosmic observations.

  11. D-dimer assay in Egyptian patients with Gaucher disease: correlation with bone and lung involvement.

    Science.gov (United States)

    Sherif, Eman M; Tantawy, Azza A G; Adly, Amira A M; Kader, Hossam A; Ismail, Eman A R

    2011-04-01

    Gaucher disease is the most frequent lysosomal storage disorder. Bone and lung involvement are two major causes of morbidity in this disease. D-dimer is a reliable indicator of active microvascular thrombosis, even in patients without overt hypercoagulation. This study aimed to assess D-dimer levels in Gaucher disease, correlating this marker to clinical characteristics and radiological parameters to investigate its role as a potential predictor for the occurrence and severity of skeletal and pulmonary manifestations. The study population consisted of 56 Egyptian patients with Gaucher disease, 36 had type 1 Gaucher disease (64.3%) and 20 had type 3 Gaucher disease (35.7%). Thirty healthy individuals were enrolled as a control group. D-dimer levels were significantly higher in all patients with Gaucher disease compared with controls (P < 0.001). Patients with type 3 showed significantly higher D-dimer concentrations compared with type 1 (P < 0.001). Pulmonary involvement was present in a significant proportion among type 3 Gaucher patients (P < 0.05), whereas bone changes were present in a higher percentage in type 1 compared with type 3 Gaucher patients. D-dimers were significantly higher in patients with abnormal MRI findings of the long bones and in those with ground glass appearance on high-resolution computerized tomography of the chest compared with patients with normal radiology (P < 0.001). Splenectomized patients displayed significantly higher D-dimer levels compared with nonsplenectomized patients (P < 0.001). Our results suggest that D-dimer is significantly elevated in Gaucher disease, particularly type 3, and may be considered as a potential marker of risk prediction of bone and lung involvement that could be used to monitor treatment response.

  12. CT Findings of Disease with Elevated Serum D-Dimer Levels in an Emergency Room Setting

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Ji Youn; Kwon, Woo Cheol; Kim, Young Ju [Dept. of Radiology, Wonju Christian Hospital, Yensei University Wonju College of Medicine, Wonju (Korea, Republic of)

    2012-01-15

    Pulmonary embolism and deep vein thrombosis are the leading causes of elevated serum D-dimer levels in the emergency room. Although D-dimer is a useful screening test because of its high sensitivity and negative predictive value, it has a low specificity. In addition, D-dimer can be elevated in various diseases. Therefore, information on the various diseases with elevated D-dimer levels and their radiologic findings may allow for accurate diagnosis and proper management. Herein, we report the CT findings of various diseases with elevated D-dimer levels in an emergency room setting, including an intravascular contrast filling defect with associated findings in a venous thromboembolism, fracture with soft tissue swelling and hematoma formation in a trauma patient, enlargement with contrast enhancement in the infected organ of a patient, coronary artery stenosis with a perfusion defect of the myocardium in a patient with acute myocardial infarction, high density of acute thrombus in a cerebral vessel with a low density of affected brain parenchyma in an acute cerebral infarction, intimal flap with two separated lumens in a case of aortic dissection, organ involvement of malignancy in a cancer patient, and atrophy of a liver with a dilated portal vein and associated findings.

  13. Clinical applicability of D-dimer assay in the diagnosis of pulmonary embolism reduces with aging

    Directory of Open Access Journals (Sweden)

    Luca Masotti

    2007-12-01

    Full Text Available Despite modern algorithms have been proposed for diagnosis of pulmonary embolism (PE, it remains understimed and often missed in clinical practice, especially in elderly patients, resulting in high morbidity and mortality when early and correctly untreated. One of the main controversial issue is represented by the role and applicability of D-dimer in the diagnostic work up of geriatric patients. Most recent guidelines in young-adult patients suggest to perform D-dimer assay by ELISA or immunoturbidimetric methods only in non high pre-test clinical probability (PTP patients; in these patients negative D-dimer can safely rule out the diagnosis of PE. This strategy is safe also in elderly patients; however the percentage of patients with non high PTP and negative D-dimer reduces progressively with age, making difficult its clinical applicability. The Authors, starting from two case reports, up date the diagnostic management of PE underling the limitations of D-dimer assay in elderly patients.

  14. Metacognitive impairments in schizophrenia are arrested at extreme levels of psychopathy: The cut-off effect.

    Science.gov (United States)

    Abu-Akel, Ahmad; Heinke, Dietmar; Gillespie, Steven M; Mitchell, Ian J; Bo, Sune

    2015-11-01

    Psychopathy and metacognitive difficulties have been associated with the occurrence of violence in schizophrenia. However, evidence suggests that nonschizophrenic psychopaths match or even outperform healthy controls on tests of metacognition. We hypothesize that the metacognitive difficulties associated with schizophrenia may be ameliorated by comorbid psychopathy. To this end, metacognition (using the Metacognition Assessment Scale-Abbreviated [MAS-A]) and psychopathy (using the Hare Psychopathy Checklist-Revised [PCL-R]) are assessed in 79 patients with schizophrenia with a history of criminal offending. Piecewise regression reveals that the association between metacognition and psychopathy changes from a negative to a positive association at a breakpoint corresponding to a score of 24 on the PCL-R. This score is within the range of the cut-off point used for the diagnosis of psychopathy in Europe, which corresponds to a score of 26 on the PCL-R. The patients scoring above 24 on the PCL-R demonstrated better overall metacognitive abilities, suggesting that these patients constitute a specific group in which schizophrenia has an attenuated impairing effect on metacognition. However, this effect was absent for the Mastery subscale of the MAS-A, which refers to the ability to use one's own mental states to solve social and psychological dilemmas. Our results suggest that the relative preservation of metacognitive abilities in schizophrenic patients with extreme levels of psychopathy may contribute to their offending behavior as it may enable them to understand how to manipulate and extort their victims. However, enhancing the Mastery domain of metacognition in these patients may attenuate this offending behavior.

  15. Potential interface slip analysis of Peribonka Dam plastic concrete cut-off wall

    Energy Technology Data Exchange (ETDEWEB)

    Morency, J.Y.; Chahde, J.; Bigras, A. [Hydro-Quebec, Montreal, PQ (Canada); Garand, P.; Rattue, A. [SNC-Lavalin Inc., Montreal, PQ (Canada)

    2006-07-01

    The Peribonka hydroelectric development is currently under construction near the confluence of the Manouane River with the Peribonka River in Quebec. It includes an 80 m high dam and two dykes of zoned earth fills with a till core, an underground power house with an installed capacity of 385 MW, a diversion tunnel and a spillway. The Peribonka dam will be built on a highly permeable alluvial foundation. The design includes a 10 m high working platform in the river between the cofferdams and a plastic concrete cut-off wall (COW) down to bedrock. The maximum depth of the COW in a narrow canyon will be 115 m. A bi-dimensional finite element stress and deformation analysis software (SDAS) was used to model the stress-strain behaviour of the foundation soils and the COW under the dam. The SDAS software made it possible to determine the vertical deformations as well as the horizontal stress distribution in the foundation soils. It was shown that due to the oedometric nature of the loading of the soil, no significant shear stress was generated due to the soil deformations in the foundation below the axis of the dam. However, the finite element program did not allow hyperbolic model slip elements. As such, it was not possible to evaluate if negative skin friction occurred at the soilplastic concrete interface. For that reason, a one-dimensional model allowing the simulation of negative or positive friction between the soil and the COW was developed. This model considered the elastic-plastic behaviour of the COW using a hyperbolic model. It showed that nowhere, except in the upper 2 to 3 m of the COW embedment in the core, was negative friction able to mobilize the full value of the internal friction angle of the soil. 4 refs., 1 tab., 9 figs.

  16. Elevation in D-dimer concentrations is positively correlated with gestation in normal uncomplicated pregnancy

    Directory of Open Access Journals (Sweden)

    Jeremiah ZA

    2012-08-01

    Full Text Available Zaccheaus A Jeremiah,1 Teddy C Adias,2 Margaret Opiah,3 Siyeoforiye P George,4 Osaro Mgbere,5 Ekere J Essien61Department of Medical Laboratory Sciences, Niger Delta University, Wilberforce Island, Nigeria; 2Bayelsa State College of Health Technology, Ogbia-Town, Nigeria; 3Department of Maternal and Child Health, Faculty of Nursing, Niger Delta University, Wilberforce Island, Nigeria; 4Postgraduate Hematology Unit, Rivers State University of Science and Technology, Port Harcourt, Nigeria; 5Houston Department of Health and Human Services, Houston, TX, USA; 6Institute of Community Health, University of Houston, Houston, TX, USABackground: D-dimer levels have been reported to increase progressively during pregnancy, but how this affects Nigerian women is not well known.Objective: This study aims to determine the D-dimer concentration and its relationship to other coagulation parameters among pregnant women in Port Harcourt, Nigeria.Method: In a cross-sectional observational study conducted in Port Harcourt, Nigeria, 120 pregnant women and 60 nonpregnant controls, drawn from a tertiary health institution in the Niger Delta, Nigeria, were assessed, using the standard procedures, for the following parameters: D-dimer concentration, prothrombin time, activated partial thromboplastin time, platelet count, hemoglobin, and packed cell volume.Results: The median D-dimer concentration of 153.1 ng/mL in the pregnant group was found to be significantly elevated when compared with the control value of 118.5 ng/mL (t = 2.348, P = 0.021. Conversely, there was a marked depression in the platelet count among pregnant women (193.5 × 109/L when compared with 229.0 × 109/L in the control group (t = 3.424; P = 0.001. There was no statistically significant difference in the values for the prothrombin time and the activated partial thromboplastin time between pregnant and nonpregnant women. D-dimer values correlated positively and significantly with gestation (r = 0

  17. D-Dimer Levels before HIV Seroconversion Remain Elevated Even after Viral Suppression and Are Associated with an Increased Risk of Non-AIDS Events.

    Science.gov (United States)

    Freiberg, Matthew S; Bebu, Ionut; Tracy, Russell; So-Armah, Kaku; Okulicz, Jason; Ganesan, Anuradha; Armstrong, Adam; O'Bryan, Thomas; Rimland, David; Justice, Amy C; Agan, Brian K

    2016-01-01

    The mechanism underlying the excess risk of non-AIDS diseases among HIV infected people is unclear. HIV associated inflammation/hypercoagulability likely plays a role. While antiretroviral therapy (ART) may return this process to pre-HIV levels, this has not been directly demonstrated. We analyzed data/specimens on 249 HIV+ participants from the US Military HIV Natural History Study, a prospective, multicenter observational cohort of >5600 active duty military personnel and beneficiaries living with HIV. We used stored blood specimens to measure D-dimer and Interleukin-6 (IL-6) at three time points: pre-HIV seroconversion, ≥6 months post-HIV seroconversion but prior to ART initiation, and ≥6 months post-ART with documented HIV viral suppression on two successive evaluations. We evaluated the changes in biomarker levels between time points, and the association between these biomarker changes and future non-AIDS events. During a median follow-up of 3.7 years, there were 28 incident non-AIDS diseases. At ART initiation, the median CD4 count was 361cells/mm3; median duration of documented HIV infection 392 days; median time on ART was 354 days. Adjusted mean percent increase in D-dimer levels from pre-seroconversion to post-ART was 75.1% (95% confidence interval 24.6-148.0, p = 0.002). This increase in D-dimer was associated with a significant 22% increase risk of future non-AIDS events (p = 0.03). Changes in IL-6 levels across time points were small and not associated with future non-AIDS events. In conclusion, ART initiation and HIV viral suppression does not eliminate HIV associated elevation in D-dimer levels. This residual pathology is associated with an increased risk of future non-AIDS diseases.

  18. Cut-off analysis of 19-cell Yb-doped double-cladding rod-type photonic crystal fibers.

    Science.gov (United States)

    Poli, F; Coscelli, E; Alkeskjold, T T; Passaro, D; Cucinotta, A; Leick, L; Broeng, J; Selleri, S

    2011-05-09

    Yb-doped double-cladding large mode area rod-type photonic crystal fibers are a key component for power scaling in fiber laser systems. Recently, designs with 19-cell core defect, that is with 19 missing air-holes in the center of the photonic crystal cladding, have been proposed, with reported core diameter up to 100 μm. In this paper an analysis of the cut-off wavelength of the first high-order mode in such low-NA fibers is reported, accounting for different approaches for the definition of the cladding effective index. Results have shown that taking into account the finite fiber cross-section and considering the first cladding mode of the actual fiber is mandatory to obtain a correct estimate of the cut-off wavelength.

  19. Ordinary mode reflectometry. Modification of the scattering and cut-off responses due to the shape of localized density fluctuations

    Energy Technology Data Exchange (ETDEWEB)

    Fanack, C.; Boucher, I.; Heuraux, S.; Leclert, G. [Centre National de la Recherche Scientifique (CNRS), 54 - Nancy (France). Lab. de Physique du Solide; Clairet, F.; Zou, X.L. [Association Euratom-CEA, Centre d`Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee

    1996-01-01

    Ordinary wave reflectometry in a plasma containing a localized density perturbation is studied with a 1-D model. The phase response is studied as a function of the wavenumber and position of the perturbation. It is shown that it strongly depends upon the perturbation shape and size. For a small perturbation wavenumber, the response is due to the oscillation of the cut-off layer. For larger wavenumbers, two regimes are found: for a broad perturbation, the phase response is an image of the perturbation itself; for a narrow perturbation, it is rather an image of the Fourier transform. For tokamak plasmas it turns out that, for the fluctuation spectra usually observed, the phase response comes primarily from those fluctuations that are localized at the cut-off. Results of a 2-D numerical model show that geometry effects are negligible for the scattering by radial fluctuations. (author). 18 refs.

  20. [Receiver operating characteristic analysis and the cost--benefit analysis in determination of the optimal cut-off point].

    Science.gov (United States)

    Vránová, J; Horák, J; Krátká, K; Hendrichová, M; Kovaírková, K

    2009-01-01

    An overview of the use of Receiver Operating Characteristic (ROC) analysis within medicine is provided. A survey of the theory behind the analysis is offered together with a presentation on how to create a ROC curve and how to use Cost--Benefit analysis to determine the optimal cut-off point or threshold. The use of ROC analysis is exemplified in the "Cost--Benefit analysis" section of the paper. In these examples, it can be seen that the determination of the optimal cut-off point is mainly influenced by the prevalence and the severity of the disease, by the risks and adverse events of treatment or the diagnostic testing, by the overall costs of treating true and false positives (TP and FP), and by the risk of deficient or non-treatment of false negative (FN) cases.

  1. ANP, BNP and D-dimer predict right ventricular dysfunction in patients with acute pulmonary embolism

    DEFF Research Database (Denmark)

    Mortensen, Jann; Jensen, Claus V; Von Der Recke, Peter;

    2010-01-01

    The aim of this study was to predict right ventricular dysfunction (RVD) using plasma concentration of D-dimer, pro-atrial natriuretic peptide (pro-ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1) and cardiac troponin I (TNI) in patients with pulmonary embolism (PE).......The aim of this study was to predict right ventricular dysfunction (RVD) using plasma concentration of D-dimer, pro-atrial natriuretic peptide (pro-ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1) and cardiac troponin I (TNI) in patients with pulmonary embolism (PE)....

  2. Improved nonparametric estimation of the optimal diagnostic cut-off point associated with the Youden index under different sampling schemes.

    Science.gov (United States)

    Yin, Jingjing; Samawi, Hani; Linder, Daniel

    2016-07-01

    A diagnostic cut-off point of a biomarker measurement is needed for classifying a random subject to be either diseased or healthy. However, the cut-off point is usually unknown and needs to be estimated by some optimization criteria. One important criterion is the Youden index, which has been widely adopted in practice. The Youden index, which is defined as the maximum of (sensitivity + specificity -1), directly measures the largest total diagnostic accuracy a biomarker can achieve. Therefore, it is desirable to estimate the optimal cut-off point associated with the Youden index. Sometimes, taking the actual measurements of a biomarker is very difficult and expensive, while ranking them without the actual measurement can be relatively easy. In such cases, ranked set sampling can give more precise estimation than simple random sampling, as ranked set samples are more likely to span the full range of the population. In this study, kernel density estimation is utilized to numerically solve for an estimate of the optimal cut-off point. The asymptotic distributions of the kernel estimators based on two sampling schemes are derived analytically and we prove that the estimators based on ranked set sampling are relatively more efficient than that of simple random sampling and both estimators are asymptotically unbiased. Furthermore, the asymptotic confidence intervals are derived. Intensive simulations are carried out to compare the proposed method using ranked set sampling with simple random sampling, with the proposed method outperforming simple random sampling in all cases. A real data set is analyzed for illustrating the proposed method.

  3. Successful use of combined high cut-off haemodialysis and bortezomib for acute kidney injury associated with myeloma cast nephropathy.

    LENUS (Irish Health Repository)

    Ward, F

    2012-05-01

    We present the case of a 58-year old female with de novo dialysis-dependent acute kidney injury (AKI) secondary to myeloma cast nephropathy. The patient underwent extended high cut-off haemodialysis (HCO-HD), in conjunction with bortezomib-based chemotherapy, and soon became dialysis independent with normal renal function. To our knowledge, this is the first time this treatment strategy has been employed successfully in an Irish centre.

  4. Sinus cut-off sign: A helpful sign in the CT diagnosis of diaphragmatic rupture associated with pleural effusion

    Energy Technology Data Exchange (ETDEWEB)

    Kaya, Seyda Ors [Pamukkale University Medical School, Department of Thoracic Surgery, Denizli (Turkey)]. E-mail: skaya@pamukkale.edu.tr; Karabulut, Nevzat [Pamukkale University Medical School, Department of Radiology, Denizli (Turkey); Yuncu, Gokhan [Pamukkale University Medical School, Department of Thoracic Surgery, Denizli (Turkey); Sevinc, Serpil [Pamukkale University Medical School, Department of Thoracic Surgery, Denizli (Turkey); Kiroglu, Yilmaz [Pamukkale University Medical School, Department of Radiology, Denizli (Turkey)

    2006-08-15

    The objective of our study was to describe the 'sinus cut-off' sign at CT in the diagnosis of diaphragmatic rupture in patients with blunt abdominal trauma complicated with pleural effusion, and evaluate its utility in an experimental model. Between January 2004 and March 2005, we observed an unusual interruption of costophrenic sinus at CT in three patients with blunt abdominal trauma accompanied with pleural effusion. This observation prompted us to evaluate the utility of this sign in an experimental model. Laparotomically, we created 2 cm diapragmatic lacerations at each hemidiaphragm in two rabbits and pushed up the abdominal viscera with omentum through the defect. To simulate hemothorax, we also injected 5-10 mL of diluted contrast material into the pleural space. Using a dual-slice helical CT scanner, limited thoracoabdominal CT examination was performed before and after injection of intrapleural contrast material. The images were analyzed for the presence of CT signs for diaphragmatic injury. The left posterior costophrenic sulcus was interrupted in all of the three patients with left pleural effusion. While it was associated with other findings of diaphragmatic injury, the 'sinus cut-off sign' was the sole finding in one patient. The sinus cut-off sign was observed on the CT scans of 100% of the rabbits with a left and right sided diaphragmatic rupture. The 'sinus cut-off sign' is useful and can increase the CT detection of acute diaphragmatic injury associated with pleural effusion.

  5. Cut-off values of blood mercury concentration in relation to increased body mass index and waist circumference in Koreans.

    Science.gov (United States)

    Bae, Suhyun; Park, Soo-Jung; Yeum, Kyung-Jin; Choi, Beomhee; Kim, Young-Sang; Joo, Nam-Seok

    2016-04-01

    Blood mercury (methyl-mercury) from environmental exposure may be related to inflammation in our body. We investigated the cut-off values of blood mercury concentration in relation to increased body mass index (BMI) and waist circumference. On the basis of data obtained from the Korea National Health and Nutrition Examination Survey (KNHANES, 2008-2012), 11,159 subjects (5543 males and 5616 females) were analyzed cross-sectionally. Partial correlation, linear regression, and analysis of covariance (according to the mercury quartile) tests were performed to evaluate the relationship between blood mercury and BMI or waist circumference. In addition, we determined the cut-off values of blood mercury concentration in relation to increased BMI and waist circumference in both genders. Mean values of blood mercury concentration were 5.07 ± 0.07 μg/L in males and 3.59 ± 0.04 μg/L in females. After log transformation of blood mercury, significant (p waist circumference. BMI and waist circumference showed a significant and gradual increase as mercury quartile increased in both genders. Blood mercury concentration was weakly but significantly (p waist circumference. Cut-off values of blood mercury concentration correlated with increased BMI and waist circumference were around 3.95 μg/L in males and 3.40 μg/L in females.

  6. Interstellar flow longitude from pickup ion cut-off observations at 1 AU with STEREO and ACE

    Science.gov (United States)

    Möbius, E.; Lee, M. A.; Gloeckler, G.; Drews, C.; Keilbach, D.

    2016-11-01

    A precision determination of the interstellar neutral (ISN) flow direction is important in several ways. As a cardinal axis of the heliosphere it has strong leverage on the plane subtended by the ISN velocity and interstellar magnetic field vector, which controls the shape of the heliosphere and its interaction with the interstellar medium. Continuing observations of the ISN flow through the heliosphere for several decades allow the search for potential temporal variations of the ISN flow and comparison with astronomical observations. Recent efforts to obtain a consistent ISN vector and temperature with Ulysses and IBEX neutral gas observations point to remaining uncertainties and potential systematic effects. In particular, IBEX measurements provide a very precise relation between ISN flow longitude and speed via the hyperbolic trajectory equation, but they contain larger uncertainties along the parameter tube defined by this relation. The pickup ion (PUI) cut-off variation with ecliptic longitude at 1 AU can provide a complementary determination of the ISN flow longitude with high precision. We compare STEREO PLASTIC and ACE SWICS observations with a simple analytical model of the cut-off. We perform a Pearson correlation analysis of the cut-off as a function of ecliptic longitude with its mirrored function and obtain the symmetry axis with a statistical uncertainty <0.1°. Here we test variations of this value due to Poisson fluctuations in the original data with simulations and due to systematic effects with multi year and location ACE SWICS and STEREO PLASTIC samples.

  7. Insulin sensitivity indices: a proposal of cut-off points for simple identification of insulin-resistant subjects.

    Science.gov (United States)

    Radikova, Z; Koska, J; Huckova, M; Ksinantova, L; Imrich, R; Vigas, M; Trnovec, T; Langer, P; Sebokova, E; Klimes, I

    2006-05-01

    Demanding measurement of insulin sensitivity using clamp methods does not simplify the identification of insulin resistant subjects in the general population. Other approaches such as fasting- or oral glucose tolerance test-derived insulin sensitivity indices were proposed and validated with the euglycemic clamp. Nevertheless, a lack of reference values for these indices prevents their wider use in epidemiological studies and clinical practice. The aim of our study was therefore to define the cut-off points of insulin resistance indices as well as the ranges of the most frequently obtained values for selected indices. A standard 75 g oral glucose tolerance test was carried out in 1156 subjects from a Caucasian rural population with no previous evidence of diabetes or other dysglycemias. Insulin resistance/sensitivity indices (HOMA-IR, HOMA-IR2, ISI Cederholm, and ISI Matsuda) were calculated. The 75th percentile value as the cut-off point to define IR corresponded with a HOMA-IR of 2.29, a HOMA-IR2 of 1.21, a 25th percentile for ISI Cederholm, and ISI Matsuda of 57 and 5.0, respectively. For the first time, the cut-off points for selected indices and their most frequently obtained values were established for groups of subjects as defined by glucose homeostasis and BMI. Thus, insulin-resistant subjects can be identified using this simple approach.

  8. The first cut-off wall in the Indian Himalayas for the dam of the Dhauliganga hydroelectric project

    Energy Technology Data Exchange (ETDEWEB)

    Brunner, W.G. [Bauer Maschinen GmbH, Berlin (Germany)

    2006-07-01

    This paper provided details a Bauer cutter used to build a cut-off wall for the Dhaulinganga power plant project in the Himalayan mountains. The dam for the project was built as a 56 m high concrete-faced rockfill dam with a length of 270 m at the crown. A cut-off wall was constructed on the upstream side of the dam extending down from the dam's plinth to the bedrock level. A Bauer cutter was used to key the cut-off wall straight into the bedrock, which omitted the need for a grout curtain. The cut-off wall is 1 m thick and 70 m deep, with a total area of 8000 m{sup 2}. The wall was constructed as a series of primary and secondary panels. Excavation of the panels was carried out in single bites by the Bauer DHG hydraulic diaphragm wall grabs, supported a box chisel, cross chisel and a Bauer BC 40 rock cutter. Trench stability was provided by bentonite slurry. The closing forces were activated by a cylinder which was installed vertically inside the base body. The Bauer cutter continuously removed soil and rock from the bottom of the trench for mixing with the bentonite slurry. The slurry was then pumped through a ring main of hose pipes to a desanding plant where it was cleaned and returned to the trench. Advantages offered by using the cutter included a consistently high output, an extremely high degree of verticality, watertight joints, and the ability to cut through hard boulders. Use of the cutter at the Dhaulinganga site showed that the project could not be carried out successfully without the use of the cutter, which was used whenever grab and chisel methods were unable to achieve satisfactory rates of penetration. Deployment of the cutter was essential to key the cut-off wall into the underlying bedrock. It was concluded that the Dhualinganga project will provide a model for future power generation projects in the Indian Himalayas. 11 figs.

  9. Serum D-dimer concentrations in nephrotic syndrome track with albuminuria, not estimated glomerular filtration rate.

    LENUS (Irish Health Repository)

    Sexton, D J

    2012-01-01

    The nephrotic syndrome is associated with an increased risk of venous and arterial thrombosis. There are little published data on the distribution, interpretation or determinants of serum D-dimer levels in patients with the nephrotic syndrome. We aimed to describe this relationship.

  10. Variable D-dimer thresholds for diagnosis of clinically suspected acute pulmonary embolism

    NARCIS (Netherlands)

    Van der Hulle, T.; Den Exter, P. L.; Erkens, P. G. M.; Van Es, J.; Mos, I. C. M.; Ten Cate, H.; Kamphuisen, P. W.; Hovens, M. M. C.; Buller, H. R.; Klok, F. A.; Huisman, M. V.

    2013-01-01

    Background Computed tomography pulmonary angiography (CTPA) is frequently requested using diagnostic algorithms for suspected pulmonary embolism (PE). For suspected deep vein thrombosis, it was recently shown that doubling the D-dimer threshold in patients with low pretest probability safely decreas

  11. D-dimer is useful in the diagnosis of cortical venous sinus thrombosis

    Directory of Open Access Journals (Sweden)

    Misra Usha

    2009-01-01

    Full Text Available Background: Estimations of D-dimer correlate with deep vein thrombosis and pulmonary thromboembolism and may serve as a marker of cortical venous sinus thrombosis (CVST. Aim: To study the usefulness of D-dimer in the diagnosis of CVST. Materials and Methods: A total of 26 patients with CVST were subjected to a detailed medical history and neurological evaluation. A cranial MRI was carried out on a 1.5T scanner using T1, T2, and DWI sequences and two-dimensional time of flight MR venography. D-dimer was estimated using a rapid latex agglutination slide test using monoclonal antibodies. Results: The age of patients ranged between 16 and 70 years old (median 31 years old; 8 were males and were examined after a mean duration of 22 days of symptoms. Cortical venous thrombosis was attributed to puerperium in 4 patients, infection in 5 patients, and pregnancy, dehydration, insect bite, and migraine in 1 patient each. Superior sagittal sinus was involved in 15 patients, transverse sinus in 16 patients, straight sinus in 3 patients, sigmoid sinus in 7 patients, and cavernous and deep system in 1 patient each. A total of 12 patients had more than one sinus involvement. D-dimer was positive in 20 patients and correlated with the duration of symptoms but not with the extent of sinus thrombosis and the outcome. Conclusion: D-dimer is useful in patients suspected of CVST and patients with positive test results should be urgently sent for MR imaging.

  12. The Diagnostic Value of D-dimer, Procalcitonin and CRP in Acute Appendicitis

    Directory of Open Access Journals (Sweden)

    Bulent Kaya, Baris Sana, Cengiz Eris, Koray Karabulut, Orhan Bat, Riza Kutanis

    2012-01-01

    Full Text Available BACKGROUND: The early diagnosis of acute abdomen is of great importance. To date, several inflammatory markers have been used for the diagnosis of acute abdominal conditions, including acute appendicitis. The aim of this study was to evaluate the diagnostic utility of D-dimer, Procalcitonin (PCT and C-reactive protein (CRP measurements in the acute appendicitis.METHODS: This prospective study was conducted between March 1st, 2010 and July 1st, 2011. In this period, seventy-eight patients were operated with the diagnosis of acute appendicitis, and D-dimer, PCT and CRP levels of the patients were measured. The patients were grouped as phlegmonous appendicitis (Group 1, gangrenous appendicitis (Group 2, perforated appendicitis (Group 3 and negative appendectomy (Group 4 according to the surgical findings and histopathological results.RESULTS: Of 78 patients, 54 (69.2 % were male and 24 (30.8 % were female, and the mean age was 25.4 ± 11.1 years (range, 18 to 69 years. 66 (84.6 % patients had increased leukocyte count (white blood cell count. The PCT values were higher than the upper normal limit in 20 (25.6% patients, followed by D-dimer in 22 (28.2 % patients and CRP in 54 (69.2 % patients. The diagnostic value of leukocyte count and CRP in acute appendicitis was higher than that of the other markers, whereas leukocyte count showed very low specificity. CRP values were higher in perforated appendicitis when compared with the phlegmonous appendicitis (p<0.05. However, PCT and D-dimer showed lower diagnostic values (26% and 31%, respectively.CONCLUSION: An increase in CRP levels alone is not sufficient to make the diagnosis of acute appendicitis. However, CRP levels may differentiate between phlegmonous appendicitis and perforated appendicitis. Due to their low sensitivity and diagnostic value, PCT and D-dimer are not better markers than CRP for the diagnosis of acute appendicitis.

  13. Concentration of D-dimers in healthy cats and sick cats with and without disseminated intravascular coagulation (DIC).

    Science.gov (United States)

    Tholen, Inger; Weingart, Christiane; Kohn, Barbara

    2009-10-01

    The objective of this prospective study was to measure concentrations of D-dimers in 48 cats with various diseases and in 20 healthy cats to evaluate the sensitivity and specificity for D-dimers to diagnose disseminated intravascular coagulation (DIC). The cats were classified as having DIC if an underlying disease and at least three of the following criteria were present: thrombocytopenia, prolonged activated partial thromboplastin time, prothrombin time or thrombin time, schistocytes and/or a reduced antithrombin activity. D-dimer concentrations were measured using a semi-quantitative latex agglutination (LA) test (Accuclot D-Dimer, Sigma Diagnostics). The D-dimer test was positive for 8/12 cats with DIC and for 16/36 sick cats without DIC. D-dimers were negative for all healthy control cats. The comparison of the sick cats with DIC and those without DIC revealed a specificity and sensitivity of the D-dimer test of 56% and 67%; a comparison of the results for healthy cats and cats with DIC revealed a specificity and sensitivity of 100% and 67%, respectively. The D-dimer LA test is only of limited value for the diagnosis of DIC in cats.

  14. High frequency cut-off in 1/f conductivity noise of hole-doped La1-x Ca x MnO3 manganite single crystals

    Science.gov (United States)

    Przybytek, Jacek; Fink-Finowicki, Jan; Puźniak, Roman; Jung, Grzegorz

    2016-05-01

    High frequency bias and temperature-dependent Lorentzian cut-off has been observed in the 1/f spectra of the conductivity fluctuations in low hole-doped ferromagnetic insulating La1-x Ca x MnO3 manganite at low temperatures. The cut-off frequency depends on dc current bias and temperature. The high frequency cut-off has been tentatively associated with intrinsic limits of the appearance of 1/f noise in the hopping regime of the Coulomb glass state. The assumption is validated by the fact that the Efros-Shklovskii temperature {{T}\\text{ES}} , estimated from the fit of the model to the experimentally measured temperature dependence of the cut-off frequency, has the same value as the temperature {{T}\\text{ES}} evaluated independently from the temperature dependence of the resistivity in the corresponding temperature range.

  15. D-dimer for prediction of long-term outcome in cryptogenic stroke patients with patent foramen ovale.

    Science.gov (United States)

    Kim, Young Dae; Song, Dongbeom; Nam, Hyo Suk; Lee, Kijeong; Yoo, Joonsang; Hong, Geu-Ru; Lee, Hye Sun; Nam, Chung Mo; Heo, Ji Hoe

    2015-08-31

    Patent foramen ovale (PFO) is a potential cause of cryptogenic stroke, given the possibility of paradoxical embolism from venous to systemic circulation. D-dimer level is used to screen venous thrombosis. We investigated the risk of embolism and mortality according to the presence of PFO and D-dimer levels in cryptogenic stroke patients. A total of 570 first-ever cryptogenic stroke patients who underwent transesophageal echocardiography were included in this study. D-dimer was assessed using latex agglutination assay during admission. The association of long-term outcomes with the presence of PFO and D-dimer levels was investigated. PFO was detected in 241 patients (42.3 %). During a mean 34.0 ± 22.8 months of follow-up, all-cause death occurred in 58 (10.2 %) patients, ischaemic stroke in 33 (5.8 %), and pulmonary thromboembolism in 6 (1.1 %). Multivariate Cox regression analysis showed that a D-dimer level of > 1,000 ng/ml was an independent predictor for recurrent ischaemic stroke in patients with PFO (hazard ratio 5.341, 95 % confidence interval 1.648-17.309, p=0.005), but not in those without PFO. However, in patients without PFO, a D-dimer level of > 1,000 ng/ml was independently related with all-cause mortality. The risk of pulmonary thromboembolism tended to be high in patients with high D-dimer levels, regardless of PFO. Elevated D-dimer levels in cryptogenic stroke were predictive of the long-term outcome, which differed according to the presence of PFO. The coexistence of PFO and a high D-dimer level increased the risk of recurrent ischaemic stroke. The D-dimer test in cryptogenic stroke patients may be useful for predicting outcomes and deciding treatment strategy.

  16. Different diagnostic cut-off values of urinary fractionated metanephrines according to sex for the diagnosis of pheochromocytoma in Korean subjects.

    Science.gov (United States)

    Sohn, Seo Young; Park, Hyung Doo; Lee, Soo Youn; Kim, Jung Han; Jung, Byong Chang; Kim, Hye Jeong; Jang, Hye Won; Kim, Kwang Won; Lee, Moon Kyu; Min, Yong Ki; Kim, Jae Hyeon

    2012-01-01

    The diagnosis of pheochromocytoma depends on the documentation of catecholamine overproduction. The use of urinary fractionated metanephrines has recently become common for the diagnosis of pheochromocytoma. In order to avoid false positive and false negative results, optimal cut-off levels are necessary; however, there have been few published reports on whether different cut-off levels are needed to diagnose pheochromocytoma according to sex. We reviewed the medical records of 815 subjects (including 103 pheochromocytoma patients) whose of 24-h urinary fractionated metanephrine was measured using high-performance liquid chromatography methods and adrenal imaging at Samsung Medical Center. Receiver operating characteristic (ROC) curves were used to determine cut-off values according to sex. The upper limit values of fractionated metanephrine in healthy volunteers and the control group were significantly higher in male subjects compared with females. When we applied cut-off values according to sex, the diagnostic efficacies (defining a positive test as either metanephrine or normetanephrine levels above the cut-off value) were a sensitivity of 96% in male subjects and 98.1% in female subjects and a specificity of 88.6% in male subjects and 94.1% in female subjects. However, when we applied cut-off values without considering sex, the specificity decreased from 88.6% to 77.8% in male subjects. In this study, urinary fractionated metanephrines had a high level of sensitivity and specificity for the diagnosis of pheochromocytoma. However, diagnostic cut-off values were higher in male subjects than in female subjects. Therefore, different cut-off values may be needed according to sex to diagnose pheochromocytoma in Koreans.

  17. Waist circumference cut-off values for the prediction of cardiovascular risk factors clustering in Chinese school-aged children: a cross-sectional study

    OpenAIRE

    Xu Ying; Du Lin; Li Yanping; Hu Xiaoqi; Hills Andrew P; Liu Ailing; Byrne Nuala M; Ma Guansheng

    2010-01-01

    Abstract Background Waist circumference has been identified as a valuable predictor of cardiovascular risk in children. The development of waist circumference percentiles and cut-offs for various ethnic groups are necessary because of differences in body composition. The purpose of this study was to develop waist circumference percentiles for Chinese children and to explore optimal waist circumference cut-off values for predicting cardiovascular risk factors clustering in this population. Met...

  18. Cut-Offs and Response Criteria for the Hospital Universitario La Princesa Index (HUPI) and Their Comparison to Widely-Used Indices of Disease Activity in Rheumatoid Arthritis

    OpenAIRE

    González-Álvaro, Isidoro; Castrejón, Isabel; Ortiz, Ana M; Toledano, Esther; Castañeda, Santos; García-Vadillo, Alberto; Carmona, Loreto; ,

    2016-01-01

    Objective To estimate cut-off points and to establish response criteria for the Hospital Universitario La Princesa Index (HUPI) in patients with chronic polyarthritis. Methods Two cohorts, one of early arthritis (Princesa Early Arthritis Register Longitudinal [PEARL] study) and other of long-term rheumatoid arthritis (Estudio de la Morbilidad y Expresión Clínica de la Artritis Reumatoide [EMECAR]) including altogether 1200 patients were used to determine cut-off values for remission, and for ...

  19. Gestational Age-specific Cut-off Values Are Needed for Diagnosis of Subclinical Hypothyroidism in Early Pregnancy.

    Science.gov (United States)

    Kim, Hye Sung; Kim, Byoung Jae; Oh, Sohee; Lee, Da Young; Hwang, Kyu Ri; Jeon, Hye Won; Lee, Seung Mi

    2015-09-01

    During the first trimester of pregnancy, thyroid-stimulating hormone (TSH) >2.5 mIU/L has been suggested as the universal criterion for subclinical hypothyroidism. However, TSH levels change continuously during pregnancy, even in the first trimester. Therefore the use of a fixed cut-off value for TSH may result in a different diagnosis rate of subclinical hypothyroidism according to gestational age. The objective of this study was to obtain the normal reference range of TSH during the first trimester in Korean gravida and to determine the diagnosis rate of subclinical hypothyroidism using the fixed cut-off value (TSH >2.5 mIU/L). The study population consisted of pregnant women who were measured for TSH during the first trimester of pregnancy (n=492) and nonpregnant women (n=984). Median concentration of TSH in pregnant women was lower than in non-pregnant women. There was a continuous decrease of median TSH concentration during the first trimester of pregnancy (median TSH concentration: 1.82 mIU/L for 3+0 to 6+6 weeks; 1.53 mIU/L for 7+0 to 7+6 weeks; and 1.05 mIU/L for 8+0 to 13+6 weeks). Using the fixed cut-off value of TSH >2.5 mIU/L, the diagnosis rate of subclinical hypothyroidism decreased significantly according to the gestational age (GA) at TSH (25% in 3+0 to 6+6 weeks, 13% in 7+0 to 7+6 weeks, and 9% for 8+0 to 13+6 weeks, Phypothyroidism.

  20. Bronchodilator response cut-off points and FEV 0.75 reference values for spirometry in preschoolers

    Science.gov (United States)

    Burity, Edjane Figueiredo; Pereira, Carlos Alberto de Castro; Jones, Marcus Herbert; Sayão, Larissa Bouwman; de Andrade, Armèle Dornelas; de Britto, Murilo Carlos Amorim

    2016-01-01

    ABSTRACT Objective: To determine the cut-off points for FEV1, FEV0.75, FEV0.5, and FEF25-75% bronchodilator responses in healthy preschool children and to generate reference values for FEV0.75. Methods: This was a cross-sectional community-based study involving children 3-5 years of age. Healthy preschool children were selected by a standardized questionnaire. Spirometry was performed before and after bronchodilator use. The cut-off point of the response was defined as the 95th percentile of the change in each parameter. Results: We recruited 266 children, 160 (60%) of whom were able to perform acceptable, reproducible expiratory maneuvers before and after bronchodilator use. The mean age and height were 57.78 ± 7.86 months and 106.56 ± 6.43 cm, respectively. The success rate for FEV0.5 was 35%, 68%, and 70% in the 3-, 4-, and 5-year-olds, respectively. The 95th percentile of the change in the percentage of the predicted value in response to bronchodilator use was 11.6%, 16.0%, 8.5%, and 35.5% for FEV1, FEV0.75, FEV0.5, and FEF25-75%, respectively. Conclusions: Our results provide cut-off points for bronchodilator responsiveness for FEV1, FEV0.75, FEV0.5, and FEF25-75% in healthy preschool children. In addition, we proposed gender-specific reference equations for FEV0.75. Our findings could improve the physiological assessment of respiratory function in preschool children. PMID:27812631

  1. Exploration of the optimal diameter cut-off value in patients with nonfunctional adrenal tumor suitable for surgery

    Directory of Open Access Journals (Sweden)

    Dan-dan LIU

    2016-12-01

    Full Text Available Objective  To analyze the pathology of the patients with nonfunctional adrenal tumor (NFA, and explore the optimal diameter cut-off value. Methods  The clinical data of 243 patients with NFA, evaluated in the Department of Endocrinology and operated in the Department of Urology of General Hospital of Chinese PLA from Feb. 1996 to Jan. 2016, were collected. The patients were divided into two groups according to pathology: those in real demand of surgery were classified to the surgery-need group (n=57, while the others were categorized as the surgery-unwanted group (n=186. The general situation, pathological type and tumor diameter of the two groups and the factors affecting the surgery were analyzed, and the ROC curve was used to explore the optimal surgery cut-off value, which represents the maximum value of the sum of sensitivity and specificity. Results  Of the 57 patients in surgery-need group (27 males and 30 females, the lesions were on the right in 31 cases, on the left in 25 cases, and on bilateral sides in 1 case; the median of lesion diameter was 4.5cm, and the average age was 41.5±12.1 years old. Of the 186 patients in surgery-unwanted group (87 males and 99 females, the lesions were on the right in 99 cases, on the left in 86 cases, and on bilateral sides in 1 case; the median of lesion diameter was 3.0cm, and the average age was 50.6±10.9 years old. Logistic regression revealed that lesion diameter might be a risk factor (OR=1.340, 95%CI 1.266-1.418, P=0.000 and age be a protective factor (OR=0.942, 95%CI 0.929-0.955, P=0.000 for real demand of surgery. The area under the ROC curve (AUC of lesion diameter was 0.757(95%CI 0.681-0.833. The optimal cut-off value was 4.1cm (sensitivity 60.7% and specificity 83.0%. Conclusions  Younger patients with bigger lesion diameter may have greater possibility for surgery. The optimal surgery cut-off value of the lesion diameter is 4.1cm. DOI: 10.11855/j.issn.0577-7402.2016.11.11

  2. Determination of the optimal cut-off point for ELISA test for diagnosis of brucellosis in Iran

    Directory of Open Access Journals (Sweden)

    Soudbakhsh A

    2009-09-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Finding a reliable diagnostic method for brucellosis is the most challengeable problem. In this study we determined the optimal diagnostic cut-off point for ELISA test."n"nMethods: We gathered 56 confirmed cases of brucellosis. Furthermore blood samples from 126 controls including 73 healthy controls and 53 without brucellosis febrile patients were collected. In all of the cases and controls ELISA Ig G and ELISA Ig M levels were measured and compared with each other by Box plot graph and the Receiver Operating Characteristic (ROC curve. The sensitivity and specificity of ELISA Ig G and Ig M were fixed in different cut-off values and Ig G and Ig M levels yielding maximal sensitivity plus specificity were selected for determination of optimal cut-off point."n"nResults: The nineteen patients had positive blood cultures for Brucella melitensis. The standard agglutination test results were 1/160 or more in 54 patients. The Box plot graph indicated a high degree of dispersion for Ig G and Ig M data in patients with brucellosis compared with febrile patients without brucellosis and healthy controls. We observed partial overlap for Ig M data (not for Ig G between cases and controls. The area under ROC curve for

  3. Accuracy and cut-off point selection in three-class classification problems using a generalization of the Youden index.

    Science.gov (United States)

    Nakas, Christos T; Alonzo, Todd A; Yiannoutsos, Constantin T

    2010-12-10

    We study properties of the index J(3), defined as the accuracy, or the maximum correct classification, for a given three-class classification problem. Specifically, using J(3) one can assess the discrimination between the three distributions and obtain an optimal pair of cut-off points c(1)sum of the correct classification proportions will be maximized. It also serves as the generalization of the Youden index in three-class problems. Parametric and non-parametric approaches for estimation and testing are considered and methods are applied to data from an MRS study on human immunodeficiency virus (HIV) patients.

  4. A neoantigenic determinant in the D-dimer fragment of fibrin

    NARCIS (Netherlands)

    Lugovskoy, E.V.; Kolesnikova, I.N.; Gritsenko, P.G.; Zolotareva, E.N.; Gaffney, P.; Nieuwenhuizen, W.; Komisarenko, S.V

    2002-01-01

    Monoclonal antibody (mAb) III-3b binds D-dimer with Kd = 1.4 × 10-10 M without cross-reaction with fibrin(ogen). The epitope for this mAb is in Bβ134-190, presumably in Bβ155-160. The latter site is buried in the coiled coil structure of fibrin(ogen) but it is exposed as a neoantigenic determinant i

  5. Dynamic Changes, Cut-Off Points, Sensitivity, and Specificity of Laboratory Data to Differentiate Macrophage Activation Syndrome from Active Disease

    Directory of Open Access Journals (Sweden)

    Raheleh Assari

    2015-01-01

    Full Text Available Purpose. To compare the laboratory data and changes in these data between patients with MAS and patients with flare-up of the autoimmune diseases. Methods. In a prospective study, the static laboratory data and dynamic changes in the selected data in 17 consecutive patients with MAS and 53 patients with active disease of SJIA, PJIA, Kawasaki disease, and SLE were compared. The ROC curve analysis was used to evaluate cut-off points, sensitivity, and specificity of the static and dynamic laboratory data to differentiate between MAS and active disease. Results. In the MAS group, the mean CRP3, ALT, AST, total bilirubin, ferritin, LDH, PT, PTT, and INR were significantly higher and the mean WBC2, PMN2, Lymph2, Hgb1, 2, 3, ESR2, serum albumin, and sodium were significantly lower than in control group. Some of the important cut-off points were PLT2 38.5, ALT > 38, WBC 5277 ng/mL. Conclusion. The dynamic changes in some laboratory data, especially PLT, can differentiate between MAS and active disease. The changes in WBC, PMN, and ESR and the levels of the liver enzymes may also be helpful in the early differentiation. Very high levels of ferritin may also help the diagnosis along with other clinical and laboratory signs.

  6. Cut-off scaling of high-harmonic generation driven by a femtosecond visible optical parametric amplifier

    Science.gov (United States)

    Cirmi, Giovanni; Lai, Chien-Jen; Granados, Eduardo; Huang, Shu-Wei; Sell, Alexander; Hong, Kyung-Han; Moses, Jeffrey; Keathley, Phillip; Kärtner, Franz X.

    2012-10-01

    We studied high-harmonic generation (HHG) in Ar, Ne and He gas jets using a broadly tunable, high-energy optical parametric amplifier (OPA) in the visible wavelength range. We optimized the noncollinear OPA to deliver tunable, femtosecond pulses with 200-500 µJ energy at the 1 kHz repetition rate with excellent spatiotemporal properties, suitable for HHG experiments. By tuning the central wavelength of the OPA while keeping other parameters (energy, duration and beam size) constant, we experimentally studied the scaling law of cut-off energy with the driver wavelength in helium. Our measurements show a λ1.7 + 0.2 dependence of the HHG cut-off photon energy over the full visible range in agreement with previous experiments of near- and mid-IR wavelengths. By tuning the central wavelength of the driver source, the high-order harmonic spectra in the extreme ultraviolet cover the full range of photon energy between ˜25 and ˜100 eV. Due to the high coherence intrinsic in HHG, as well as the broad and continuous tunability in the extreme UV range, a high energy, high repetition rate version of this source might be an ideal seed for free electron lasers.

  7. STS-114: Engine Cut-Off Sensors Are a No-Go: Teaching Notes for NASA Case Study

    Science.gov (United States)

    Ransom, Khadijah S.; Johnson, Grace K.

    2013-01-01

    This case study format is intended to simulate the experience of facing the same difficult challenges and making the same critical decisions as managers, engineers, and scientists in the Space Shuttle Program. It has been designed for use in the classroom setting to help students develop skills related to decision-making. Students will read about the engine cut-off sensor anomaly which created challenges during the STS-114 mission and have the opportunity to make decisions as lead NASA engineers and Mission Management Team members. Included within this document are three case study presentation options - class discussion, group activity, and open-ended research. Please read the full case prior to in-class presentation to allow ample time for students' analysis and reflection, as well as to prepare additional questions. activities or exercises, material selection, etc. Depending upon the setting of your presentation and the number of participants, please choose at least one presentation format beforehand and plan accordingly. You may expect the following learning objectives by using the proposed formats. Learning Objectives: To enable students to experience the responsibilities of NASA management, engineers, and analysis; to discover possible procedures for investigating system anomalies; to become familiar with the liquid hydrogen low level engine cut-off sensor, including its function, connecting components, and location within the Space Shuttle; and to encourage critical analysis and stimulating discussion of Space Shuttle mission challenges.

  8. Accuracy of cut-off value by measurement of third molar index: Study of a Colombian sample.

    Science.gov (United States)

    De Luca, Stefano; Aguilar, Lina; Rivera, Marcela; Palacio, Luz Andrea Velandia; Riccomi, Giulia; Bestetti, Fiorella; Cameriere, Roberto

    2016-04-01

    The aim of this cross-sectional study was to test the accuracy of cut-off value of 0.08 by measurement of third molar index (I3M) in assessing legal adult age of 18 years in a sample of Colombian children and young adults. Digital orthopantomographs of 288 Colombian children and young adults (163 girls and 125 boys), aged between 13 and 22 years, were analysed. Concordance correlation coefficient (ρc) and κ statistics (Cohen's Kappa coefficient) showed that repeatability and reproducibility are high for both intra- and inter-observer error. κ statistics for intra- and inter-observer agreement in decision on adult or minor was 0.913 and 0.877, respectively. Age distribution gradually decreases as I3M increases in both girls and boys. For girls, the sensitivity test was 95.1% (95% CI 87.1%-95%) and specificity was 93.8% (95% CI 87.1%-98.8%). The proportion of correctly classified individuals was 95.1%. For boys, the sensitivity test was 91.7% (95% CI 85.1%-96.8%) and specificity was 90.6% (95% CI 82.1%-97.8%). The proportion of correctly classified individuals was 89.7%. The cut-off value of 0.08 is highly useful to determine if a subject is 18 years of age or older or not.

  9. Determination of the accuracy and optimal cut-off point for ELISA test in diagnosis of human brucellosis in Iran.

    Science.gov (United States)

    Hasibi, Mehrdad; Jafari, Sirus; Mortazavi, Habibollah; Asadollahi, Marjan; Esmaeeli Djavid, Gholamreza

    2013-01-01

    In endemic area the most challenging problem for brucellosis is to find a reliable diagnostic method. In this case-control study, we investigated the accuracy of ELISA test for diagnosis of human brucellosis and determined the optimal cut-off value for ELISA results in Iran. The laboratory diagnosis of brucellosis was performed by blood isolation of Brucella organism with a BACTEC 9240 system and/or detection of Brucella antibodies by standard agglutination test (titer ≥ 1:160). Serum level of ELISA IgG and ELISA IgM from 56 confirmed cases of brucellosis and 126 controls were compared with each other by Box plot graph and Receiver Operating Characteristic (ROC) curve. Box plot graphs showed the high degree of dispersion for IgG and IgM data in patients compared with all controls. We observed partially overlapping for IgM data (not for IgG) between cases and controls in graphs. The area under ROC curve for distinguishing between cases and controls was larger for IgG compared to IgM. Based on results of this study, ELISA IgG test was more reliable than ELISA IgM test in diagnosis of human brucellosis in Iran. Using a cut-off of 10 IU/ml and 50 IU/ml had most sensitivity (92.9%) and most specificity (100%) for ELISA IgG test, respectively.

  10. Preoperative diagnosis of breast diseases by dynamic MR mammography. Cut off point establishment for signal intensity ratio

    Energy Technology Data Exchange (ETDEWEB)

    Tsuchiya, Juji; Nagata, Takayasu; Kawagoe, Hajime; Tachibana, Susumu; Kajima, Toshihiko; Hoshino, Mutsuo [Ibi General Hospital, Gifu (Japan); Uno, Takashi; Shimokawa, Kuniyasu

    1997-12-01

    We have revealed that a dynamic study of the breast using MR imaging technique can estimate objectively benign-malignant differentiative diagnosis. Subjects were 41 cases of breast lesion, including 13 cases of breast cancer, 21 cases of mastopathy, six cases of fibroadenoma and one case of intraductal papillomatosis and the results of them were investigated in comparison with histopathological diagnosis. As so the method, we drew up time-signal intensity ratio curve plotting signal intensity ratio at each 30 second of dynamic MR mammography after Gd-DTPA administration. We found a especially high significant difference between cancer and mastopathy, within 90 second after Gd-DTPA administration (p=0.0000). Still more, we established cut off point concerning with establishment of 95% confidence interval, that is, at 30 second after Gd-DTPA administration of point equivalent 1.53 at 60 second equivalent 2.00, at 90 second equivalent 2.47, and about this estimating maneuver using the cut off point we named Dynamic ratio method. We can estimate preoperatively not only benign-malignant differentiative diagnosis with breast tumor, but also neighboring infiltration and lymph node metastasis of breast cancer using this Dynamic ratio method. Over again, Dynamic ratio method provides fine information to preoperative decision of resecting region for breast conserving surgery. The efficiency of this method is sensitivity=92.3%, specificity=89.3% and positive predictive value=80.0%. (author)

  11. Effects of inductive waves on multi-band below-cut-off transmission in waveguides loaded with dielectric metamaterials

    Directory of Open Access Journals (Sweden)

    Fang Chen

    2014-10-01

    Full Text Available Unusual backward and forward wave propagation in below cut-off waveguides loaded with dielectric metamaterials comprised of linear arrays of dielectric resonators (DRs has been investigated by using theoretical, numerical, and experimental methods. Transmission bands were shown to correspond to three lowest resonances in arrays and were analyzed by using the concepts of magneto- and electro-inductive (MI and EI waves describing the transfer of resonance excitation along the chains of coupled resonators. Equivalent circuit models (ECMs have been constructed to describe MI and EI wave propagation and to obtain the dispersion diagrams. Good agreement between the obtained data and the results of full-wave simulations, theoretical calculations, and experiments provided an opportunity to determine coupling coefficients characterizing interaction between DRs in arrays at various resonances. It was shown that ripples observed in below cut-off transmission bands are transmission resonances caused by Fabry-Perot oscillations of inductive waves at impedance mismatch at the array ends. Fitting the transmission spectra for MI/EI waves in arrays, calculated by using the Transfer Matrix Method to the spectra obtained by using full-wave simulations/measurements, allowed for determining the ECM parameters to fully characterize the DR array properties.

  12. CFT dual of the AdS Dirichlet problem : Fluid/Gravity on cut-off surfaces

    CERN Document Server

    Brattan, Daniel K; Loganayagam, R; Rangamani, Mukund

    2011-01-01

    We study the gravitational Dirichlet problem in AdS spacetimes with a view to understanding the boundary CFT interpretation. We define the problem as bulk Einstein's equations with Dirichlet boundary conditions on fixed timelike cut-off hypersurface. Using the fluid/gravity correspondence, we argue that one can determine non-linear solutions to this problem in the long wavelength regime. On the boundary we find a conformal fluid with Dirichlet constitutive relations, viz., the fluid propagates on a `dynamical' background metric which depends on the local fluid velocities and temperature. This boundary fluid can be re-expressed as an emergent hypersurface fluid which is non-conformal but has the same value of the shear viscosity as the boundary fluid. The hypersurface dynamics arises as a collective effect, wherein effects of the background are transmuted into the fluid degrees of freedom. Furthermore, we demonstrate that this collective fluid is forced to be non-relativistic below a critical cut-off radius in...

  13. Variation of D-dimer values as assessment of pulmonary thromboembolism during adulticide treatment of heartworm disease in dogs.

    Science.gov (United States)

    Carretón, E; Morchón, R; González-Miguel, J; Simón, F; Juste, M C; Montoya-Alonso, J A

    2013-07-01

    Dirofilaria immitis adult worms lodged in the pulmonary arteries are the causative agent of heartworm disease, characterized by endarteritis and obstruction of the blood flow. Dying worms form embolic fragments which trigger thrombosis. Thus, pulmonary thromboembolism is an inevitable consequence of successful adulticide therapy. Clinical signs of pulmonary thromboembolisms are highly variable and non-specific, and its diagnosis is often difficult to obtain. The D-dimer assay is considered the marker of choice for dogs with a suspicion of pulmonary thromboembolism. The aim of the present study was to evaluate the variation of D-dimer and platelets in 15 heartworm-infected dogs during the adulticide treatment with ivermectin, doxycycline and melarsomine. Nine dogs were considered to have a low parasite burden and 6 had a high burden. Measurements were carried out on days 0, 60, and afterwards weekly on days 67, 75, 82, 91, 98, 106, 113, 120, and finally on day 271 after treatment. 40% of dogs showed pathological concentrations of D-dimer and 40% showed slight or mild thrombocytopenia on day 0. The levels of D-dimer decreased by day 60, probably due to the joint action of the ivermectin, doxycycline and exercise restriction. All dogs with high parasite burden showed elevated values of D-dimer on several occasions during the treatment, reaching the highest values the first and second week after the injections of melarsomine. Only 33.3% of the dogs with low parasite burden showed elevated D-dimer levels at some point during the treatment, and all of them showed undetectable levels from the third week after the first injection of melarsomine. On day 271, all dogs showed undetectable levels of D-dimer. There was no correlation between thrombocytopenia and levels of D-dimer during the treatment. The evaluation of serum D-dimer appears to be a supportive test in the assessment and monitoring of pulmonary thromboembolism in dogs with heartworm disease during the adulticide

  14. Validation of an immunochromatographic D-dimer test to presumptively identify menstrual fluid in forensic exhibits.

    Science.gov (United States)

    Holtkötter, Hannah; Dierig, Lisa; Schürenkamp, Marianne; Sibbing, Ulla; Pfeiffer, Heidi; Vennemann, Marielle

    2015-01-01

    Identifying the biological source of a crime scene stain can be crucial for police investigations in many scenarios. Blood is one of the most common fluids found, and accurate differentiation between peripheral blood and menstrual fluid could provide valuable information regarding the issue of consent in sexual assault cases. For the detection of menstrual fluid, no easy-to-use presumptive test is available to date. Therefore, this study aimed to validate a simple immunochromatographic test for the indication of menstrual fluid, focusing on a D-dimer assay. The Clearview® rapid D-dimer test provides a diagnostic assay for the detection of fibrin degradation products. We validated the sensitivity and robustness of the assay using fresh and dried menstrual fluid samples, body fluid mixtures, diluted samples, and casework swabs. Cross reactivity was tested for saliva, semen, vaginal fluid, and blood. No false positive results were obtained; it was possible to successfully analyze mixtures, highly diluted samples, and casework swabs. The results of this study indicate that the D-dimer assay reliably detects menstrual fluid in forensic exhibits and is easy to implement into the current workflow of body fluid identification.

  15. d-dimer testing as an adjunct to ultrasonography in patients with clinically suspected deep vein thrombosis: prospective cohort study

    Science.gov (United States)

    Bernardi, Enrico; Prandoni, Paolo; Lensing, Anthonie W A; Agnelli, Giancarlo; Guazzaloca, Giuliana; Scannapieco, Gianluigi; Piovella, Franco; Verlato, Fabio; Tomasi, Cristina; Moia, Marco; Scarano, Luigi; Girolami, Antonio

    1998-01-01

    Objective To investigate the efficacy of using a rapid plasma d-dimer test as an adjunct to compression ultrasound for diagnosing clinically suspected deep vein thrombosis. Design d-dimer concentrations were determined in all patients with a normal ultrasonogram at presentation. Repeat ultrasonography was performed 1 week later only in patients with abnormal d-dimer test results. Main outcome measure Patients with normal ultrasonograms were not treated with anticoagulants and were followed for 3 months for thromboembolic complications. Setting University research and affiliated centres. Subjects 946 patients with clinically suspected deep vein thrombosis. Results Ultrasonograms were abnormal at presentation in 260 (27.5%) patients. Of the remaining 686 patients tested for d-dimer, 88 (12.8%) had abnormal concentrations. During follow up venous thromboembolic complications occurred in one of the 598 patients who were not treated with anticoagulants and who had an initial normal ultrasonogram and d-dimer concentration, whereas thromboembolic complications occurred in two of the 83 untreated patients who had abnormal d-dimer concentrations but a normal repeat ultrasonogram. The cumulative incidence of venous thromboembolic complications during follow up was 0.4% (95% confidence interval 0% to 0.9%). The rapid plasma d-dimer test used as an adjunct to compression ultrasonography resulted in a reduction in the mean number of repeat ultrasound examinations and additional hospital visits from 0.7 to 0.1 per patient. Conclusions Testing for d-dimer as an adjunct to a normal baseline ultrasound examination decreased the number of subsequent ultrasound examinations considerably without any increased risk of venous thromboembolic complications in patients not receiving anticoagulants. The use of ultrasound and testing for d-dimer enabled treatment decisions to be made at the time of presentation in most patients. Key messagesPatients with clinically suspected deep vein

  16. A clinically based prognostic index for diffuse large B-cell lymphoma with a cut-off at 70 years of age significantly improves prognostic stratification: population-based analysis from the Danish Lymphoma Registry.

    Science.gov (United States)

    Gang, Anne O; Pedersen, Michael; d'Amore, Francesco; Pedersen, Lars M; Jensen, Bo A; Jensen, Paw; Møller, Michael B; Mourits-Andersen, Hans T; Pedersen, Robert S; Klausen, Tobias W; de N Brown, Peter

    2015-01-01

    The introduction of rituximab and generally improved health among elderly patients have increased the survival of patients with diffuse large B-cell lymphoma (DLBCL). The International Prognostic Index (IPI) from 1992 is based on pre-rituximab data from clinical trials including several lymphoma subtypes. We applied IPI factors to a population-based rituximab-treated cohort of 1990 patients diagnosed 2000-2010 and explored new factors and the optimal prognostic age cut-off for DLBCL. Multivariate-analyses (MVA) confirmed the prognostic value of all IPI factors except the presence of > 1 extranodal lesion. The optimal age cut-off was 70 years. In a MVA of albumin, lymphocyte count, sex, immunoglobulin G, bulky disease, hemoglobin and B-symptoms, only albumin was prognostic. We propose: (1) a modified DLBCL prognostic index (DLBCL-PI) including: age (70 years), performance status (PS), lactate dehydrogenase (LDH), stage and albumin level, and (2) a separate age-adjusted DLBCL-PI for patients ≤ 70 years including PS, LDH, albumin level and > 1 extranodal lesion, however excluding stage.

  17. Elevated D-dimers in attacks of hereditary angioedema are not associated with increased thrombotic risk

    Science.gov (United States)

    Reshef, A; Zanichelli, A; Longhurst, H; Relan, A; Hack, C E

    2015-01-01

    Background Recommended management of attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency (C1-INH-HAE) includes therapy with exogenous C1INH. Thrombotic/thromboembolic events (TEE) have been reported with plasma-derived C1INH, but so far none with recombinant human C1INH (rhC1INH). This phase III, randomized, placebo (saline)-controlled study evaluated the safety of rhC1INH 50 IU/kg for the treatment of acute attacks in 74 patients with C1-INH-HAE. Methods Monitoring for TEE and assessment of risk of deep vein thrombosis (DVT) by the Wells prediction rule were performed, and levels of fibrin degradation products (plasma D-dimers) were assessed before study drug administration (baseline), 2 h, and 7 days posttreatment. Results Plasma D-dimer levels were elevated in 80% of the patients (median [25th–75th percentiles]: 2149 [480–5105] μg/l; normal ≤250 μg/l) and were higher in patients with submucosal (abdominal, oropharyngeal–laryngeal) attacks (3095 [890–10000] μg/l; n = 29) compared with subcutaneous (peripheral, facial) attacks (960 [450–4060] μg/l; n = 35). Median plasma D-dimer levels were comparable across treatment groups at baseline (1874 [475–4568] μg/l rhC1INH; 2259 [586–7533] μg/l saline) and 2 h postinfusion (2389 [760–4974] μg/l rhC1INH; 2550 [310–8410] μg/l saline); median plasma D-dimer levels were decreased by Day 7 in both groups (425 [232–3240] μg/l rhC1INH; 418 [246–2318] μg/l saline). No increased risk of DVT was identified, nor any TEE reported in rhC1INH treated or controls. Conclusion Elevated plasma D-dimer levels were associated with acute C1-INH-HAE attacks, particularly with submucosal involvement. However, rhC1INH therapy was not associated with thrombotic events. PMID:25640891

  18. Impact of High-Cut-Off Dialysis on Renal Recovery in Dialysis-Dependent Multiple Myeloma Patients: Results from a Case-Control Study.

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    Hans U Gerth

    Full Text Available High-cut-off hemodialysis (HCO-HD can effectively reduce high concentrations of circulating serum free light chains (sFLC in patients with dialysis-dependent acute kidney injury (AKI due to multiple myeloma (MM. Therefore, the aim of this study was to analyze renal recovery in a retrospective single-center cohort of dialysis-dependent MM patients treated with either conventional HD (conv. HD or HCO-HD.The final cohort consisted of 59 patients treated with HCO-HD (n = 42 or conv. HD (n = 17. A sustained sFLC response was detected in a significantly higher proportion of HCO-HD patients (83.3% compared with conv. HD patients (29.4%; p = 0.007. The median duration of sFLC required to reach values <1000 mg/l was 14.5 days in the HCO-HD group and 36 days in the conv. HD group. The corresponding rates of renal recovery were 64.3% and 29.4%, respectively (chi-squared test, p = 0.014. Multivariate regression and decision tree analysis (recursive partitioning revealed HCO-HD (adjusted odds ratio [OR] 6.1 [95% confidence interval (CI 1.5-24.5], p = 0.011 and low initial uric acid values (adjusted OR 1.3 [95%CI 1.0-1.7], p = 0.045 as independent and paramount variables associated with a favorable renal outcome.In summary, the results from this retrospective case-control study suggest in addition to novel agent-based chemotherapy a benefit of HCO-HD in sFLC removal and renal outcome in dialysis-dependent AKI secondary to MM. This finding was especially pertinent in patients with low initial uric acid values, resulting in a promising renal recovery rate of 71.9%. Further prospective studies are warranted.

  19. D-二聚体的检测及临床应用%Detection and Application of D-dimer

    Institute of Scientific and Technical Information of China (English)

    张勇

    2011-01-01

    D-dimer is one of specific degradation products of cross-linked fibrin,D-dimer levels increase reflects the enhancement of secondary thrombolytic activity in vivo.In view of the formation principle of D-dimer has been widely used in clinical diagnosis and treatment,the clinical testing and application of D-dimer are emphatically reviewed.%D-二聚体是交联纤维蛋白的特异性降解产物之一,D-二聚体水平增高反映体内继发性纤溶活性增强.鉴于D-二聚体的形成原理已被广泛应用于临床诊断和治疗,现着重对D-二聚体的临床检测及应用作一综述.

  20. Prognostic associations of preoperative plasma levels of fibrinogen and D-dimer after curative resection in patients with colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    王俊锋

    2013-01-01

    Objective To explore the associations of preoperative plasma levels of fibrinogen and D-dimer with clinico-pathologic parameters and overall survival in colorectal cancer patients after curative resection.Methods From

  1. Suggested cut-off values for vitamin D as a risk marker for total and cardiac death in patients with suspected acute coronary syndrome

    Directory of Open Access Journals (Sweden)

    Patrycja Anna Naesgaard

    2016-02-01

    Full Text Available Background: Several studies have demonstrated an association between low vitamin D levels and cardiovascular risk. Vitamin D cut off levels are still under debate. Objectives: To assess two cut-off levels, 40 nmol/L and 70 nmol/L, respectively, for vitamin D measured as 25-hydroxyvitamin D [25(OHD] in chest pain patients with suspected acute coronary syndrome.Methods: We investigated 1853 patients from coastal-Norway and inland Northern-Argentina. A similar database was used for pooling of data. 2-year follow-up data including all-cause mortality, cardiac death and sudden cardiac death in the total patient population were analyzed, applying univariate and multivariable analysis. Results: 255 patients with known vitamin D concentrations died. In the multivariable analysis, there was a decrease in total mortality above a cut-off level of 40 nmol/L and a decrease in cardiac death above a cut-off level of 70 nmol/L, [HRs of 0.66 (95% CI, 0.50 – 0.88, p = 0.004 and 0.46 (95% CI, 0.22 – 0.94, p = 0.034, respectively].Conclusion: Vitamin D cut-off levels of 40 nmol/L and 70 nmol/L, were related to total mortality and cardiac death, respectively.

  2. On a holographic dark energy model with a Nojiri-Odintsov cut-off in general relativity

    CERN Document Server

    Khurshudyan, M

    2016-01-01

    In this paper we consider the models of the accelerated expanding large scale universe~(according to general relativity) containing a generalized holographic dark energy with a Nojiri - Odintsov cut - off. The second component of the darkness is assumed to be the pressureless cold dark matter according to observed symmetries of the large scale universe. Moreover, we assume specific forms of the interaction between these two components and besides the cosmographic analysis, we discuss appropriate results from $Om$ and $Om3$ analysis and organize a closer look to the models via the statefinder hierarchy analysis, too. In this way we study mainly impact of the interaction on the dynamics of the background of our universe~(within specific forms of interaction). To complete the cosmographic analysis, the present day values of the statefinder parameters $(r,s)$ and $(\\omega^{\\prime}_{de}, \\omega_{de})$ has been estimated for all cases and the validity of the generalized second law of thermodynamics is demonstrated....

  3. NUMERICAL SIMULATION OF 3-D TURBULENT FLOWS IN A CUT-OFF VALVE AND ANALYSIS OF FLOW CHARACTERISTICS IN PIPE

    Institute of Scientific and Technical Information of China (English)

    He Zhi-guo; Mao Gen-hai; Yuan Xing-ming

    2003-01-01

    The 3-D turbulent flows in a valve pipe were described by the incompressible Reynolds-averaged Navier-Stokes equations with an RNG k-ε turbulence model. With the finite volume method and a body-fitted coordinate system, the discretised equations were solved by the SIMPLEST algorithm. The numerical result of a cut-off valve with curved inlet shows the flow characteristics and the main cause of energy loss when fluid flows through a valve. And then, the boundaries of valve were modified in order to reduce the energy loss. The computational results of modified valve show that the numerical value of turbulent kinetic energy is lower, and that the modified design of the 3-D valve boundaries is much better. The analysis of the result also shows that RNG k-ε turbulence model can successfully be used to predict the 3-D turbulent separated flows and the secondary flow inside valve pipes.

  4. How does a low-mass cut-off in the stellar IMF affect the evolution of young star clusters?

    CERN Document Server

    Kouwenhoven, M B N; de Grijs, R; Rose, M; Kim, Sungsoo S

    2014-01-01

    We investigate how different stellar initial mass functions (IMFs) can affect the mass loss and survival of star clusters. We find that IMFs with radically different low-mass cut-offs (between 0.1 and 2 Msun) do not change cluster destruction time-scales as much as might be expected. Unsurprisingly, we find that clusters with more high-mass stars lose relatively more mass through stellar evolution, but the response to this mass loss is to expand and hence significantly slow their dynamical evolution. We also argue that it is very difficult, if not impossible, to have clusters with different IMFs that are initially "the same", since the mass, radius and relaxation times depend on each other and on the IMF in a complex way. We conclude that changing the IMF to be biased towards more massive stars does speed up mass loss and dissolution, but that it is not as dramatic as might be thought.

  5. Evaluation of the Diagnostic Accuracy of Serum D-Dimer Levels in Pregnant Women with Adnexal Torsion

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    Hasan Onur Topçu

    2015-01-01

    Full Text Available We aimed to evaluate the diagnostic accuracy of serum D-dimer levels in pregnant women with adnexal torsion (AT. The pregnant women with ovarian cysts who suffered from pelvic pain were divided into two groups; the first group consisted of the cases with surgically proven as AT (n = 17 and the second group consisted of the cases whose pain were resolved in the course of follow-up period without required surgery (n = 34. The clinical characteristics and serum D-dimer levels were compared between the groups. Patients with AT had a higher rate of elevated serum white blood cell (WBC count (57% vs. 16%, p = 0.04 and serum D-dimer levels (77% vs. 21%, p < 0.01 on admission in the study group than in the control group. Elevated D-dimer and cyst diameter larger than 5 cm yielded highest sensitivity (82% for each; whereas the presence of nausea and vomiting and elevated CRP had the highest specificity (85% and 88%, respectively. This is the first study that evaluates the serum D-dimer levels in humans in the diagnosis of AT, and our findings supported the use of D-dimer for the early diagnosis of AT in pregnant women.

  6. The Development of Appropriate Waist-to-Hip Ratio Cut- off Points: Survey in Large Iranian Adult Population

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    A.S. Jahanlou

    2015-07-01

    Full Text Available Introduction & Objective: Proportion of Waist-to-Hip Ratio (WHR is an indicator of abdominal obesity, which is supported by some studies but rejected by others. The aim of this study was to examine the accuracy of the WHR and obtain suitable cut- off points for detecting obesity among adult Iranians. Materials & Methods: In this cross-sectional-descriptive study the sample consisted of 19366 adults. The data collection took place from 2009 to 2014, using Bioelectrical Impedance Analysis (BIA. The following data were obtained: WHR, Percentile of Body Fat (PBF, To-tal Fat (TF, and Soft Lean Mass (SLM. Sensitivity and specificity, based on World Health Organization’s Gold Standards were calculated for both sexes at three age groups. The data analysis included t-test, chi-square, ROC curve, and linear regression. Results: All study variables were correlated with each other. Age was only correlated with the WHR. Percentages of sensitivity and Negative Predictive Value (NPV were 84.2% and 85.6% in women; 21% and 50.7% in men. Increase in age was associated with increase in sensitivity in men and women, and NPV in men. The suitable cut-off points for men and women were found to be 87.5% and 83.5%, respectively. Conclusion: Waist-to-Hip ration is a suitable indictor of obesity for Iranian women but not men, especially among those who are under 59 years old. (Sci J Hamadan Univ Med Sci 2015; 22 (2: 144-151

  7. A new perspective of the climatological features of upper-level cut-off lows in the Southern Hemisphere

    Science.gov (United States)

    Pinheiro, Henri Rossi; Hodges, Kevin Ivan; Gan, Manoel Alonso; Ferreira, Nelson Jesuz

    2017-01-01

    This study presents a detailed view of the seasonal variability of upper-level cut-off lows (COLs) in the Southern Hemisphere. The COLs are identified and tracked using data from a 36-year period of the European Centre for Medium Range Weather Forecast reanalysis (ERA-Interim). The objective identification of the COLs uses a new approach, which is based on 300 hPa relative vorticity minima, and three restrictive criteria of the presence of a cold-core, stratospheric potential vorticity intrusion, and cut-off cyclonic circulation. The highest COL activity is in agreement with previous studies, located near three main continental areas (Australia, South America, and Africa), with maximum frequencies usually observed in the austral autumn. The COL mean intensity values show a marked seasonal and spatial variation, with maximum (minimum) values during the austral winter (summer), a unique feature that has not been observed previously in studies based on the geopotential. The link between intensity and lysis is examined, and finds that weaker systems are more susceptible to lysis in the vicinity of the Andes Cordillera, associated with the topographic Rossby wave. Lysis and genesis regions are close to each other, confirming that COLs are quasi-stationary systems. Also, COLs tend to move eastward and are faster over the higher latitudes. The mean growth/decay rates coincide with the major genesis and lysis density regions, such as the significant decay values across the Andes all year. As a consequence of using vorticity for the tracking method a longer lifetime of COLs is detected than in other studies, but this does not affect the total frequency of occurrence. Comparisons with other studies suggest that the differences in seasonality are due to uncertainties in the reanalyses and the methods used to identify COLs.

  8. Immunohistochemical evaluation of tissue factor, fibrin/fibrinogen and D-dimers in canine gliomas.

    Science.gov (United States)

    de la Fuente, Cristian; Pumarola, Martí; Blasco, Ester; Fernández, Francisco; Viu, Judit; Añor, Sònia

    2014-06-01

    In human gliomas, tissue factor (TF) is overexpressed, associated with the grade of malignancy and influences tumour biology. Intra-tumoural fibrin/fibrinogen deposition and activation of the fibrinolytic system also play a role in tumour cell proliferation and angiogenesis. The first aim of the present study was to investigate TF expression and the presence of fibrin/fibrinogen and D-dimers in canine glioma biopsies, graded according to the World Health Organization (WHO) classification of tumours of the central nervous system. The second aim was to investigate the occurrence of intravascular thrombosis (IVT) in canine gliomas, as a potential histological marker of glioma type or grade of malignancy. An immunohistochemical study using antibodies against TF, fibrin/fibrinogen and D-dimers was performed with 24 glioma samples, including 15 oligodendrogliomas, 6 astrocytomas and 3 mixed gliomas. Immunohistochemical data were statistically analysed to determine whether there was any relationship between glioma type and grade of malignancy. All gliomas were moderate to strongly positive for TF and the staining score was significantly higher (P = 0.04) in high-grade (III or IV) than in low-grade (II) gliomas. Intra-tumoural fibrin/fibrinogen deposition was detected in all tumour biopsies assessed, and D-dimers were detected in 17/24 gliomas. IVT was a frequent finding, but was not linked to a specific glioma type or malignancy grade. TF expression, fibrin/fibrinogen deposition, extravascular fibrinolytic system activation and IVT occur in canine gliomas. Canine glioma might be a suitable model for studying coagulation and fibrinolysis as potential therapeutic targets for human gliomas.

  9. Cut-Offs and Response Criteria for the Hospital Universitario La Princesa Index (HUPI) and Their Comparison to Widely-Used Indices of Disease Activity in Rheumatoid Arthritis

    Science.gov (United States)

    Castrejón, Isabel; Ortiz, Ana M.; Toledano, Esther; Castañeda, Santos; García-Vadillo, Alberto; Carmona, Loreto

    2016-01-01

    Objective To estimate cut-off points and to establish response criteria for the Hospital Universitario La Princesa Index (HUPI) in patients with chronic polyarthritis. Methods Two cohorts, one of early arthritis (Princesa Early Arthritis Register Longitudinal [PEARL] study) and other of long-term rheumatoid arthritis (Estudio de la Morbilidad y Expresión Clínica de la Artritis Reumatoide [EMECAR]) including altogether 1200 patients were used to determine cut-off values for remission, and for low, moderate and high activity through receiver operating curve (ROC) analysis. The areas under ROC (AUC) were compared to those of validated indexes (SDAI, CDAI, DAS28). ROC analysis was also applied to establish minimal and relevant clinical improvement for HUPI. Results The best cut-off points for HUPI are 2, 5 and 9, classifying RA activity as remission if ≤2, low disease activity if >2 and ≤5), moderate if >5 and <9 and high if ≥9. HUPI’s AUC to discriminate between low-moderate activity was 0.909 and between moderate-high activity 0.887. DAS28’s AUCs were 0.887 and 0.846, respectively; both indices had higher accuracy than SDAI (AUCs: 0.832 and 0.756) and CDAI (AUCs: 0.789 and 0.728). HUPI discriminates remission better than DAS28-ESR in early arthritis, but similarly to SDAI. The HUPI cut-off for minimal clinical improvement was established at 2 and for relevant clinical improvement at 4. Response criteria were established based on these cut-off values. Conclusions The cut-offs proposed for HUPI perform adequately in patients with either early or long term arthritis. PMID:27603313

  10. Evaluation of an Optimal Cut-Off Point for the Ki-67 Index as a Prognostic Factor in Primary Breast Cancer: A Retrospective Study

    Science.gov (United States)

    Tashima, Rumiko; Nishimura, Reiki; Osako, Tomofumi; Nishiyama, Yasuyuki; Okumura, Yasuhiro; Nakano, Masahiro; Fujisue, Mamiko; Toyozumi, Yasuo; Arima, Nobuyuki

    2015-01-01

    The Ki-67 index is an important biomarker for indicating the proliferation of cancer cells and is considered to be an effective prognostic factor for breast cancer. However, a standard cut-off point for the Ki-67 index has not yet been established. Therefore, the aim of this retrospective study was to determine an optimal cut-off point in order to establish it as a more accurate prognostic factor. Immunohistochemical analysis of the Ki-67 index was performed on 4329 patients with primary breast cancer from August 1987 to March 2012. Out of this sample, there were 3186 consecutive cases from September 1997 with simultaneous evaluations of ER, PgR and HER2 status. Cox's proportional hazard model was used to perform univariate and multivariate analyses of the factors related to OS. The hazard ratios (HR) and the p values were then compared to determine the optimal cut-off point for the Ki-67 index. The median Ki-67 index value was 20.5% (mean value 26.2%). The univariate analysis revealed that there was a statistically significant negative correlation with DFS and OS and the multivariate analysis revealed that the Ki-67 index value was a significant factor for DFS and OS. The top seven cut-off points were then carefully chosen based on the results of the univariate analysis using the lowest p-values and the highest HR as the main selection criteria. The multivariate analysis of the factors for OS showed that the cut-off point of 20% had the highest HR in all of the cases. However, the cutoff point of 20% was only a significant factor for OS in the Luminal/HER2- subtype. There was no correlation between the Ki-67 index value and OS in any of the other subtypes. These data indicate that the optimal cut-off point of 20% is the most effective prognostic factor for Luminal/HER2- breast cancer. PMID:26177501

  11. Cross section of reaction 181Ta(p,nγ)181W and the influence of the spin cut-off parameter on the cross section

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jun-Jie; HU Bi-Tao

    2011-01-01

    In this work,the program Cindy was modified to calculate the formation cross section of each energy level of residual nucleus 181W resulting from the reaction 181Ta(p,nγ)181 W.The concerned cross sections calculated at proton energy Ep=4.5-8.5 MeV agreed well with experimental results.The influence of the spin cut-off parameter in the energy level density model on the cross section was studied.The obtained results show that the influence of spin cut-off is obvious for lower energy levels.

  12. DIAGNOSTIC VALUE OF D-DIMER MEASUREMENT IN PATIENTS SUSPECTED TO HAVE CEREBRAL VENOUS THROMBOSIS

    Directory of Open Access Journals (Sweden)

    M Ghaffarpour

    2008-12-01

    Full Text Available "nAmong the causes of headache, cerebral venous and/or dural sinus thrombosis (CVT is an important challenge because of its variable clinical presentation, having negative brain CT in up to 30% of cases and unavailability of MRI in some situations. On the other hand as D-Dimer (DD test has been reported to be a sensitive test for the exclusion of venous thromboembolism, we sought whether it could be useful in the diagnosis of cerebral venous thrombosis. A prospective study of 104 consecutive patients with headache or unusual ischemic stroke (infarction in brain CT, but not compatible with any brunch of cerebral arteries, suggesting CVT was conducted between 2003 and 2005. D-Dimer test determined for all patients in the emergency ward before MRI or MRV was performed. Titers above 500 ng/ml were regarded as positive test. From a total 104 patients, 21 cases (20.2% were confirmed (by MRI and/or MRV to have CVT, 20/21 (95.7% of whom had positive DD test. In the remainder 83 (without CVT it was only positive in 16.8% (14/83, which was statistically meaningful (P < 0.001. Specificity, sensitivity, negative and positive predictive values of DD test were 83.1, 95.2, 98.6 and 58.8%, respectively, so application of this test would be useful in the diagnosis of CVT and values below 500 ng/ml make acute thrombosis unlikely.

  13. Prognostic role of D-dimer for in-hospital and 1-year mortality in exacerbations of COPD

    Directory of Open Access Journals (Sweden)

    Hu G

    2016-10-01

    Full Text Available Guoping Hu,1 Yankui Wu,2 Yumin Zhou,3 Zelong Wu,1 Liping Wei,1 Yuqun Li,1 GongYong Peng,3 Weiqiang Liang,1 Pixin Ran3 1Department of Respiratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 2Department of Respiratory Disease of People’s Hospital of Guangxi Zhuang Autonomous Region, Guangxi Zhuang Autonomous Region, 3Guangzhou Institute of Respiratory Disease, State Key Lab of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China Background and objective: Serum D-dimer is elevated in respiratory disease. The objective of our study was to investigate the effect of D-dimer on in-hospital and 1-year mortality after acute exacerbations of chronic obstructive pulmonary disease (AECOPD. Methods: Upon admission, we measured 343 AECOPD patients’ serum D-dimer levels and arterial blood gas analysis, and recorded their clinical characteristics. The level of D-dimer that discriminated survivors and non-survivors was determined using a receiver operator curve (ROC. The risk factors for in-hospital mortality were identified through univariate analysis and multiple logistic regression analyses. To evaluate the predictive role of D-dimer for 1-year mortality, univariate and multivariate Cox regression analyses were performed. Results: In all, 28 patients died, and 315 patients survived in the in-hospital period. The group of dead patients had lower pH levels (7.35±0.11 vs 7.39±0.05, P<0.0001, higher D-dimer, arterial carbon dioxide tension (PaCO2, C-reactive protein (CRP, and blood urea nitrogen (BUN levels (D-dimer 2,244.9±2,310.7 vs 768.2±1,078.4 µg/L, P<0.0001; PaCO2: 58.8±29.7 vs 46.1±27.0 mmHg, P=0.018; CRP: 81.5±66, P=0.001; BUN: 10.20±6.87 vs 6.15±3.15 mmol/L, P<0.0001, and lower hemoglobin levels (118.6±29.4 vs 128.3±18.2 g/L, P=0.001. The areas under the ROC curves of D-dimer for in-hospital death were 0

  14. Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China

    Institute of Scientific and Technical Information of China (English)

    HOU Xin Guo; ZHANG Xiu Ping; JIANG Mei; WANG Wei Qing; NING Guang; ZHENG Hui Zhen; MA Ai Xia; SUN Yu; SONG Jun; LIN Peng; LIANG Kai; WANG Chuan; LIU Fu Qiang; LI Wen Juan; XIAO Juan; GONG Lei; WANG Mei Jian; LIU Ji Dong; YAN Fei; YANG Jun Peng; WANG Ling Shu; TIAN Meng; MA Ze Qiang; ZHAO Ru Xing; JIANG Ling; CHEN Li; YANG Wei Fang; WANG Ji Xiang; LI Cheng Qiao; WANG Yu Lian; LIU Shu Min; Hu Xiu Ping

    2014-01-01

    Objective To study the optimal waist circumference (WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome (MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China.

  15. Cosmological properties and reconstruction of scalar field models of the Holographic Dark Energy model with Granda-Oliveros cut-off in Kaluza-Klein cosmology

    Science.gov (United States)

    Pasqua, Antonio; Chattopadhyay, Surajit; Assaf, Khudhair A.; Salako, Ines G.

    2016-06-01

    In this paper, we study the properties of the Holographic Dark Energy (HDE) model in the context of Kaluza-Klein (KK) cosmology with infrared cut-off given by the recently proposed by Granda-Oliveros cut-off, which contains a term proportional to the time derivative of the Hubble parameter and one proportional to the Hubble parameter squared. Moreover, this cut-off is characterized by two free parameters which are the proportional constants of the two terms of the cut-off. We derive the expression of the Equation of State (EoS) parameter ωD and of the deceleration parameter q for both non-interacting and interacting Dark Sectors and in the limiting case of a flat Dark Dominated Universe. Moreover, we study the squared speed of the sound vs2 and the statefinder diagnostic \\{r,s\\} in order to understand the cosmological properties of the model considered. We also develop a correspondence between the model considered and three scalar field models: the tachyon, the k-essence and the quintessence ones.

  16. Cut-off points for mild, moderate, and severe pain on the visual analogue scale for pain in patients with chronic musculoskeletal pain

    NARCIS (Netherlands)

    Boonstra, Anne M.; Schiphorst Preuper, Henrica R. Schiphorst; Balk, Gerlof A.; Stewart, Roy E.

    2014-01-01

    The aim of this study was to find the cut-off points on the visual analogue scale (VAS) to distinguish among mild, moderate, and severe pain, in relation to the following: pain-related interference with functioning; verbal description of the VAS scores; and latent class analysis for patients with ch

  17. Enhanced Narrow-band, Coherent Emission from a Current Source Immersed in Cut-off of a Plasma-like Medium

    Science.gov (United States)

    Hur, Min Sup; Ersfeld, Bernhard; Noble, Adam; Suk, Hyyong; Jaroszynski, Dino

    2016-10-01

    In plasma-like media sharing a similar dispersion relation, there exists a cut-off frequency to make the wave number zero. This particular situation has been understood classically in a way that the radiation impedance becomes infinite, resulting in a total reflection of an incident wave. However, in this framework of understanding the cut-off, a pure current source immersed in the cut-off region leads to infinite radiation power from Ohm's law. This is obviously unphysical and requires a different approach to address the problem. In this presentation, we show that by solving the driven time-dependent Schrödinger equation, the radiation at the cut-off frequency can be selectively enhanced by several times the pure vacuum-emission. Important question here is whether such current sources are available in practical systems. We find that quasi-current sources are actually ubiquitous as long as the conversion efficiency from the current driver to the radiation emission is low. We demonstrate two such cases by PIC simulations; THz radiation from a plasma driven by colliding laser pulses, and THz from two-color lasers enclosed by a tapered waveguide. We also discuss the previous experimental results in terms of this enhanced emission concept.

  18. Quantum fields and poisson processes II: Interaction of boson-boson and boson-fermion fields with a cut-off

    Science.gov (United States)

    Bertrand, J.; Gaveau, B.; Rideau, G.

    1985-05-01

    Quantum field evolutions are written as expectation values with respect to Poisson processes in two simple models: interaction of two boson fields (with conservation of the number of particles in one field) and interaction of a boson with a fermion field. The introduction of a cut-off ensures that the expectation values are well-defined.

  19. Waist circumference cut-off in relation to body mass index and percentage of body fat in adult women from Merida, Mexico.

    Science.gov (United States)

    Datta Banik, Sudip; Dickinson, Federico

    2015-01-01

    Waist circumference (WC) as an index of central obesity is related to body mass index (BMI) and percent body fat (PBF). Waist circumference data were analyzed to identify a WC cut-off for adult women with respect to BMI-based obesity (≥ 30 kg/m²) and PBF. The sample was 138 women aged 22 to 41 years with Maya ancestry (based on surnames) in Merida, Yucatan, measured during 2011 - 2013. Anthropometric parameters included height, body weight (BW), and BMI. The PBF was estimated by bioelectrical impedance. Estimated cut-offs per centimeter WC (80 - 99 cm) were predicted by BMI for obesity (≥ 30 kg m⁻²; binomial: Yes = 1, No = 0) and PBF (continuous variable) using binary logistic regression analyses. Mean age was 32 years, mean BMI was 29 kg m(-2) and mean WC was 89 cm. The sample exhibited high PBF (44 %), and high rates of overweight (44%) and obesity (40%). The threshold WC (≥ 93 cm) had high sensitivity (80%), specificity (82%), Youden Index value (0.62), and correct classification rate (82%). The area under the receiver operating characteristic curve was 88 %. The WC ≥ 93 cm cut-off had corresponding values for mean BMI (34 kg m⁻²) and PBF (47%). The optimal WC cut-off at 93 cm significantly identified central obesity for BMI ≥ 30 kg m⁻² and PBF for this sample.

  20. Using Logistic Regression for Validating or Invalidating Initial Statewide Cut-Off Scores on Basic Skills Placement Tests at the Community College Level

    Science.gov (United States)

    Secolsky, Charles; Krishnan, Sathasivam; Judd, Thomas P.

    2013-01-01

    The community colleges in the state of New Jersey went through a process of establishing statewide cut-off scores for English and mathematics placement tests. The colleges wanted to communicate to secondary schools a consistent preparation that would be necessary for enrolling in Freshman Composition and College Algebra at the community college…

  1. Lattice cut-off effects and their reduction in studies of QCD thermodynamics at non-zero temperature and chemical potential

    CERN Document Server

    Hegde, P; Laermann, E; Shcheredin, S

    2008-01-01

    We clarify the relation between the improvement of dispersion relations in the fermion sector of lattice regularized QCD and the improvement of bulk thermodynamic observables. We show that in the infinite temperature limit the cut-off dependence in dispersion relations can be eliminated up to O(a^n) corrections, if the quark propagator is chosen to be rotationally invariant up to this order. In bulk thermodynamic observables this eliminates cut-off effects up to the same order at vanishing as well as non-vanishing chemical potential. We furthermore show, that in the infinite temperature, ideal gas limit the dependence of finite cut-off corrections on the chemical potential is given by Bernoulli polynomials which are universal as they do not depend on a particular discretization scheme. We explicitly calculate leading and next-to-leading order cut-off corrections for some staggered and Wilson fermion type actions and compare these with exact evaluations of the free fermion partition functions. This also includ...

  2. Estimation of Saliva Cotinine Cut-Off Points for Active and Passive Smoking during Pregnancy—Polish Mother and Child Cohort (REPRO_PL)

    Science.gov (United States)

    Polanska, Kinga; Krol, Anna; Kaluzny, Pawel; Ligocka, Danuta; Mikolajewska, Karolina; Shaheen, Seif; Walton, Robert; Hanke, Wojciech

    2016-01-01

    A reliable assessment of smoking status has significant public health implications and is essential for research purposes. The aim of this study was to determine optimal saliva cotinine cut-off values for smoking during pregnancy. The analyses were based on data from 1771 women from the Polish Mother and Child Cohort. Saliva cotinine concentrations were assessed by high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-ESI + MS/MS). The saliva cotinine cut-off value for active smoking was established at 10 ng/mL (sensitivity 96%, specificity 95%) and for passive smoking at 1.5 ng/mL (sensitivity 63%, specificity 71%). About 5% of the self-reported non-smoking women were classified as smokers based on the cotinine cut-off value. Significantly more younger, single, and less educated self-reported non-smokers had a cotinine concentration higher than 10 ng/mL compared to those who were older, married, and who had a university degree. Close to 30% of the non-smokers who indicated that smoking was not allowed in their home could be classified as exposed to passive smoking based on the cut-off value. The study suggests that self-reported smoking status is a valid measure of active smoking, whereas in the case of passive smoking, a combination of questionnaire data and biomarker verification may be required. PMID:27941658

  3. A new three-component signal model to objectively select power Doppler wall filter cut-off velocity for quantitative microvascular imaging

    Science.gov (United States)

    Elfarnawany, Mai; Lacefield, James C.

    2013-03-01

    The wall-filter selection curve (WFSC) method was developed to automatically select cut-off velocities for high-frequency power Doppler imaging. Selection curves are constructed by plotting color pixel density (CPD) as a function of wall filter cut-off velocity. A new three-component mathematical model is developed to guide the design of an online implementation of the method for in vivo imaging. The model treats Doppler imaging as a signal detection task in which the scanner must distinguish intravascular pixels from perivascular and extravascular pixels and includes a cost function to identify the optimum cut-off velocity that provides accurate vascular quantification and minimizes the effect of color pixel artifacts on visualization of vascular structures. The goodness of fit of the three-component model to flow-phantom data is significantly improved compared to a previous two-component model (F test, p new model indicate that selection curves should be sampled using at least 100 cut-off velocities to ensure robust performance of the automated WFSC method and determine an upper bound on CPD variability that ensures reliable vascular quantification accuracy, defined as CPD within 5% of the reference vascular volume fraction. Results of the simulations also provide evidence that limiting the selection of the cut-off velocity to a binary choice between the middle and right end of the characteristic interval is sufficient to meet the quantification accuracy goal. The model provides an intuitive, empirical description of the relationship between system settings and blood-flow detection performance in power Doppler imaging.

  4. Detection of relevant colonic neoplasms with PET/CT: promising accuracy with minimal CT dose and a standardised PET cut-off

    Energy Technology Data Exchange (ETDEWEB)

    Luboldt, Wolfgang [Multiorgan Screening Foundation, Frankfurt (Germany); University Hospital Frankfurt, Department of Radiology, Frankfurt am Main (Germany); University Hospital Dresden, Clinic and Policlinic of Nuclear Medicine, Dresden (Germany); Volker, Teresa; Zoephel, Klaus; Kotzerke, Joerg [University Hospital Dresden, Clinic and Policlinic of Nuclear Medicine, Dresden (Germany); Wiedemann, Baerbel [University Hospital Dresden, Institute of Medical Informatics and Biometrics, Dresden (Germany); Wehrmann, Ursula [University Hospital Dresden, Clinic and Policlinic of Surgery, Dresden (Germany); Koch, Arne; Abolmaali, Nasreddin [University Hospital Dresden, Oncoray, Dresden (Germany); Toussaint, Todd; Luboldt, Hans-Joachim [Multiorgan Screening Foundation, Frankfurt (Germany); Middendorp, Markus; Gruenwald, Frank [University Hospital Frankfurt, Department of Nuclear Medicine, Frankfurt (Germany); Aust, Daniela [University Hospital Dresden, Department of Pathology, Dresden (Germany); Vogl, Thomas J. [University Hospital Frankfurt, Department of Radiology, Frankfurt am Main (Germany)

    2010-09-15

    To determine the performance of FDG-PET/CT in the detection of relevant colorectal neoplasms (adenomas {>=}10 mm, with high-grade dysplasia, cancer) in relation to CT dose and contrast administration and to find a PET cut-off. 84 patients, who underwent PET/CT and colonoscopy (n=79)/sigmoidoscopy (n=5) for (79 x 6+5 x 2)=484 colonic segments, were included in a retrospective study. The accuracy of low-dose PET/CT in detecting mass-positive segments was evaluated by ROC analysis by two blinded independent reviewers relative to contrast-enhanced PET/CT. On a per-lesion basis characteristic PET values were tested as cut-offs. Low-dose PET/CT and contrast-enhanced PET/CT provide similar accuracies (area under the curve for the average ROC ratings 0.925 vs. 0.929, respectively). PET demonstrated all carcinomas (n=23) and 83% (30/36) of relevant adenomas. In all carcinomas and adenomas with high-grade dysplasia (n=10) the SUV{sub max} was {>=}5. This cut-off resulted in a better per-segment sensitivity and negative predictive value (NPV) than the average PET/CT reviews (sensitivity: 89% vs. 82%; NPV: 99% vs. 98%). All other tested cut-offs were inferior to the SUV{sub max}. FDG-PET/CT provides promising accuracy for colorectal mass detection. Low dose and lack of iodine contrast in the CT component do not impact the accuracy. The PET cut-off SUV{sub max}{>=} 5 improves the accuracy. (orig.)

  5. D-dimer is not elevated in asymptomatic high altitude climbers after descent to 5340 m: the Mount Everest Deep Venous Thrombosis Study (Ev-DVT).

    Science.gov (United States)

    Zafren, Ken; Feldman, Joanne; Becker, Robert J; Williams, Sarah R; Weiss, Eric A; Deloughery, Tom

    2011-01-01

    We performed this study to determine the prevalence of elevated D-dimer, a marker for deep venous thrombosis (DVT), in asymptomatic high altitude climbers. On-site personnel enrolled a convenience sample of climbers at Mt. Everest Base Camp (Nepal), elevation 5340 m (17,500 ft), during a single spring climbing season. Subjects were enrolled after descent to base camp from higher elevation. The subjects completed a questionnaire to evaluate their risk factors for DVT. We then performed a D-dimer test in asymptomatic individuals. If the D-dimer test was negative, DVT was considered ruled out. Ultrasound was available to perform lower-extremity compression ultrasounds to evaluate for DVT in case the D-dimer was positive. We enrolled 76 high altitude climbers. None had a positive D-dimer test. The absence of positive D-dimer tests suggests a low prevalence of DVT in asymptomatic high altitude climbers.

  6. On the newtonian limit and cut--off scales of isothermal dark matter halos with cosmological constant

    CERN Document Server

    Sussman, R A; Sussman, Roberto A.; Hernandez, Xavier

    2003-01-01

    We examine isothermal dark matter halos in hydrostatic equilibrium with a cosmological constant Lambda =Omega_\\Lambda rho_{crit}c^2, where Omega_\\Lambda=0.7, and rho_{crit} is the present value of the critical density with h=0.65. The Newtonian limit of General Relativity yields equilibrium equations that are different from those arising by merely coupling an ``isothermal sphere'' to the Lambda-field within a Newtonian framework. The conditions for the existence and stability of circular geodesic orbits show the existence of (I) an ``isothermal region'' (0r_1) dominated by the Lambda-field, where the Newtonian potential oscillates and circular orbits exist in disconnected patches of the domain of r; (III) a ``transition region'' (r_20.008 M_\\odot {pc}^3, in agreement with rotation curve studies of dwarf galaxies. Since r_2 marks the largest radius of a stable circular orbit, it provides a ``cut off'' radius. For current estimates of rho_c and velocity dispersion of galactic structures, this is around five tim...

  7. Endogenous gamma-hydroxybutyric acid (GHB) concentrations in post-mortem specimens and further recommendation for interpretative cut-offs.

    Science.gov (United States)

    Andresen-Streichert, Hilke; Jensen, P; Kietzerow, J; Schrot, M; Wilke, N; Vettorazzi, E; Mueller, A; Iwersen-Bergmann, S

    2015-01-01

    When interpreting gamma-hydroxybutyric acid (GHB) concentrations in post-mortem specimens, a possible increase in GHB concentrations because of post-mortem generation must be considered. In this study, endogenous GHB concentrations in post-mortem biological fluids were investigated. Additionally, we review post-mortem GHB concentrations already published in the literature. Heart and peripheral blood samples, cerebrospinal fluid, urine, and vitreous humor were collected from 64 autopsies in subjects where the cause of death excluded GHB exposure. Sample analysis was carried out either on the day of autopsy or later after immediate freezing and storage at -20 °C. GHB concentrations in venous blood samples (n = 61) were GHB concentrations in cases where there were signs of beginning putrefaction at the time of autopsy (n = 9) and cases without obvious signs of putrefaction. In one case with advanced putrefaction, the GHB concentration in venous blood was 32.7 mg/L. In conclusion, for post-mortem venous blood, urine, and cerebrospinal fluid, an interpretative cut-off of 30 mg/L for GHB concentrations is suggested in cases where GHB analysis is conducted on the day of sample collection at autopsy or if samples have been stored at -20 °C immediately after collection.

  8. Kinetic Isotope Effects from QM/MM Subset Hessians: "Cut-Off" Analysis for SN2 Methyl Transfer in Solution.

    Science.gov (United States)

    Williams, Ian H

    2012-02-14

    Isotopic partition-function ratios and kinetic isotope effects for reaction of S-adenosylmethionine with catecholate in water are evaluated using a subset of 324 atoms within its surrounding aqueous environment at the AM1/TIP3P level. Two alternative methods for treating motion in the six librational degrees of freedom of the subset atoms relative to their environment are compared. A series of successively smaller subset Hessians are generated by cumulative deletion of rows and columns from the initial 972 × 972 Hessian. We find that it is better to treat these librations as vibrations than as translations and rotations and that there is no need to invoke the Teller-Redlich product rule. The validity of "cut-off" procedures for computation of isotope effects with truncated atomic subsets is assessed: to ensure errors in ln(KIE) < 1% (or 2% for the quantum-corrected KIE) for all isotopic substitutions considered, it is necessary to use a less-restrictive procedure than is suggested by the familiar two-bond cutoff rule.

  9. Urinary hepcidin identifies a serum ferritin cut-off for iron supplementation in young athletes: a pilot study.

    Science.gov (United States)

    Borrione, P; Spaccamiglio, A; Rizzo, M; Termine, A; Chierto, E; Campostrini, N; Quaranta, F; Di Gianfrancesco, A; Pigozzi, F

    2011-01-01

    The use of iron supplements should be a judicious choice, primarily when considering the possible risks deriving from an unjustified treatment. In trained athletes, levels of ferritin between 15 and 30 microg/L are frequently observed. Within this ferritin range, the usefulness of iron supplementation is still controversial. The aim of the present study is to evaluate the clinical usefulness of hepcidin assessment in the analysis of the iron status of young non-anemic athletes. Fifty young athletes were enrolled. The subjects were divided into 4 groups according to their ferritin levels. No statistically significant difference was found regarding hepcidin levels between athletes with ferritin lower than 15 microg/L and those in the 15-30 microg/L range. Similarly, no difference was found between athletes with ferritin higher than 50 microg/L and those in the 30-50 microg/L range. On the contrary, statistically significant differences were found between athletes with ferritin levels ranging from 15 to 30 microg/L and those in the 30-50 microg/L range. The present study suggests that serum ferritin levels below 30 microg/L indicate an asymptomatic iron deficiency status inhibiting hepcidin expression and that 30 microg/L should be considered the ferritin cut-off when considering an iron supplementation in young athletes.

  10. Accuracy of a cut-off value based on the third molar index: Validation in an Australian population.

    Science.gov (United States)

    Franklin, Daniel; Karkhanis, Shalmira; Flavel, Ambika; Collini, Federica; DeLuca, Stefano; Cameriere, Roberto

    2016-09-01

    According to Recommendation N°196 of the Australian Law Reform Commission (ALRC), the age at which a child reaches adulthood for the purposes of criminal law should be 18 years in all Australian jurisdictions. With specific reference to age at majority, the only tooth with development spanning adolescence (and thus the legally relevant 18 years of age) is the third molar, which limits the number of methods that can be applied from those available in the published literature. The aim of the present study is to test the accuracy of the third molar index (I3M=0.08), based on the correlation between chronological age and normalized measures of the open apices and height of the third mandibular molar, in order to assess the legal adult age of 18 years. Digital orthopantomographs of 143 living Australian subjects (72 boys and 71 girls) are analyzed. The results demonstrate that the sensitivity is 0.90 in boys and 0.90 in girls; associated specificity values are 0.85 and 0.87 respectively. We conclude that the cut-off value of I3M=0.08 is statistically robust and thus valid for forensic application in an Australian population.

  11. Values of the Wells and Revised Geneva Scores Combined with D-dimer in Diagnosing Elderly Pulmonary Embolism Patients

    Directory of Open Access Journals (Sweden)

    Dan-Jie Guo

    2015-01-01

    Full Text Available Background: Pulmonary embolism (PE can be difficult to diagnose in elderly patients because of the coexistent diseases and the combination of drugs that they have taken. We aimed to compare the clinical diagnostic values of the Wells score, the revised Geneva score and each of them combined with D-dimer for suspected PE in elderly patients. Methods: Three hundred and thirty-six patients who were admitted for suspected PE were enrolled retrospectively and divided into two groups based on age (≥65 or <65 years old. The Wells and revised Geneva scores were applied to evaluate the clinical probability of PE, and the positive predictive values of both scores were calculated using computed tomography pulmonary arteriography as a gold standard; overall accuracy was evaluated by the area under the curve (AUC of receiver operator characteristic curve; the negative predictive values of D-dimer, the Wells score combined with D-dimer, and the revised Geneva score combined with D-dimer were calculated. Results: Ninety-six cases (28.6% were definitely diagnosed as PE among 336 cases, among them 56 cases (58.3% were ≥65 years old. The positive predictive values of Wells and revised Geneva scores were 65.8% and 32.4%, respectively (P < 0.05 in the elderly patients; the AUC for the Wells score and the revised Geneva score in elderly was 0.682 (95% confidence interval [CI]: 0.612-0.746 and 0.655 (95% CI: 0.584-0.722, respectively (P = 0.389. The negative predictive values of D-dimer, the Wells score combined with D-dimer, and the revised Geneva score combined with D-dimer were 93.7%, 100%, and 100% in the elderly, respectively. Conclusions: The diagnostic value of the Wells score was higher than the revised Geneva score for the elderly cases with suspected PE. The combination of either the Wells score or the revised Geneva score with a normal D-dimer concentration is a safe strategy to rule out PE.

  12. Normal D-dimer ved dyb venøs trombose i en overekstremitet hos to patienter med pacemaker

    DEFF Research Database (Denmark)

    Byrne, Christina; Abdulla, Jawdat; Christensen, Jan Kim

    2015-01-01

    Danish guidelines recommend the use of D-dimer to exclude deep venous thrombosis (DVT) in the lower extremities. However, guidelines are lacking for DVT in the upper extremities. We describe two young women with transvenous pacemaker electrodes and symptomatic DVT in related veins. Despite a normal...... D-dimer, DVT was verified by colour Doppler ultrasound in both cases. The guidelines of American College of Chest Physicians recommend initial evaluation using colour Doppler ultrasound as front-line examination. Accordingly, we suggest a similar revision of Danish guidelines incorporating upper...... extremity DVT as well....

  13. Values of the Wells and Revised Geneva Scores Combined with D-dimer in Diagnosing Elderly Pulmonary Embolism Patients

    Institute of Scientific and Technical Information of China (English)

    Dan-Jie Guo; Can Zhao; Ya-Dan Zou; Xu-Hang Huang; Jing-Min Hu; Lin Guo

    2015-01-01

    Background:Pulmonary embolism (PE) can be difficult to diagnose in elderly patients because of the coexistent diseases and the combination of drugs that they have taken.We aimed to compare the clinical diagnostic values of the Wells score,the revised Geneva score and each of them combined with D-dimer for suspected PE in elderly patients.Methods:Three hundred and thirty-six patients who were admitted for suspected PE were enrolled retrospectively and divided into two groups based on age (_>65 or <65 years old).The Wells and revised Geneva scores were applied to evaluate the clinical probability of PE,and the positive predictive values of both scores were calculated using computed tomography pulmonary arteriography as a gold standard;overall accuracy was evaluated by the area under the curve (AUC) of receiver operator characteristic curve;the negative predictive values of D-dimer,the Wells score combined with D-dimer,and the revised Geneva score combined with D-dimer were calculated.Results:Ninety-six cases (28.6%) were definitely diagnosed as PE among 336 cases,among them 56 cases (58.3%) were >65 years old.The positive predictive values of Wells and revised Geneva scores were 65.8% and 32.4%,respectively (P < 0.05) in the elderly patients;the AUC for the Wells score and the revised Geneva score in elderly was 0.682 (95% confidence interval [CI]:0.612-0.746) and 0.655 (95% CI:0.584-0.722),respectively (P =0.389).The negative predictive values of D-dimer,the Wells score combined with D-dimer,and the revised Geneva score combined with D-dimer were 93.7%,100%,and 100% in the elderly,respectively.Conclusions:The diagnostic value of the Wells score was higher than the revised Geneva score for the elderly cases with suspected PE.The combination of either the Wells score or the revised Geneva score with a normal D-dimer concentration is a safe strategy to rule out PE.

  14. Body composition-derived BMI cut-offs for overweight and obesity in Indians and Creoles of Mauritius: comparison with Caucasians

    Science.gov (United States)

    Hunma, S; Ramuth, H; Miles-Chan, J L; Schutz, Y; Montani, J-P; Joonas, N; Dulloo, A G

    2016-01-01

    Background and Aims: Global estimates of overweight and obesity prevalence are based on the World Health Organisation (WHO) body mass index (BMI) cut-off values of 25 and 30 kg m−2, respectively. To validate these BMI cut-offs for adiposity in the island population of Mauritius, we assessed the relationship between BMI and measured body fat mass in this population according to gender and ethnicity. Methods: In 175 young adult Mauritians (age 20-42 years) belonging to the two main ethnic groups—Indians (South Asian descent) and Creoles (African/Malagasy descent), body weight, height and waist circumference (WC) were measured, total body fat assessed by deuterium oxide (D2O) dilution and trunk (abdominal) fat by segmental bioimpedance analysis. Results: Compared to body fat% predicted from BMI using Caucasian-based equations, body fat% assessed by D2O dilution in Mauritians was higher by 3–5 units in Indian men and women as well as in Creole women, but not in Creole men. This gender-specific ethnic difference in body composition between Indians and Creoles is reflected in their BMI–Fat% relationships, as well as in their WC–Trunk Fat% relationships. Overall, WHO BMI cut-offs of 25 and 30 kg m−2 for overweight and obesity, respectively, seem valid only for Creole men (~24 and 29.5, respectively), but not for Creole women whose BMI cut-offs are 2–4 units lower (21–22 for overweight; 27–28 for obese) nor for Indian men and women whose BMI cut-offs are 3–4 units lower (21–22 for overweight; 26–27 for obese). Conclusions: The use of BMI cut-off points for classifying overweight and obesity need to take into account both ethnicity and gender to avoid gross adiposity status misclassification in this population known to be at high risk for type-2 diabetes and cardiovascular diseases. This is particularly of importance in obesity prevention strategies both in clinical medicine and public health. PMID:27698347

  15. Evaluation of an Optimal Cut-Off Point for the Ki-67 Index as a Prognostic Factor in Primary Breast Cancer: A Retrospective Study.

    Directory of Open Access Journals (Sweden)

    Rumiko Tashima

    Full Text Available The Ki-67 index is an important biomarker for indicating the proliferation of cancer cells and is considered to be an effective prognostic factor for breast cancer. However, a standard cut-off point for the Ki-67 index has not yet been established. Therefore, the aim of this retrospective study was to determine an optimal cut-off point in order to establish it as a more accurate prognostic factor. Immunohistochemical analysis of the Ki-67 index was performed on 4329 patients with primary breast cancer from August 1987 to March 2012. Out of this sample, there were 3186 consecutive cases from September 1997 with simultaneous evaluations of ER, PgR and HER2 status. Cox's proportional hazard model was used to perform univariate and multivariate analyses of the factors related to OS. The hazard ratios (HR and the p values were then compared to determine the optimal cut-off point for the Ki-67 index. The median Ki-67 index value was 20.5% (mean value 26.2%. The univariate analysis revealed that there was a statistically significant negative correlation with DFS and OS and the multivariate analysis revealed that the Ki-67 index value was a significant factor for DFS and OS. The top seven cut-off points were then carefully chosen based on the results of the univariate analysis using the lowest p-values and the highest HR as the main selection criteria. The multivariate analysis of the factors for OS showed that the cut-off point of 20% had the highest HR in all of the cases. However, the cutoff point of 20% was only a significant factor for OS in the Luminal/HER2- subtype. There was no correlation between the Ki-67 index value and OS in any of the other subtypes. These data indicate that the optimal cut-off point of 20% is the most effective prognostic factor for Luminal/HER2- breast cancer.

  16. Effect of Body Mass Index on All-cause Mortality and Incidence of Cardiovascular Diseases - Report for Meta-Analysis of Prospective Studies on Optimal Cut-off Points of Body Mass Index in Chinese Adults

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Objective To verify the optimal cut-off points for overweight and obesity in Chinese adults based on the relationship of baseline body mass index (BMI) to all-cause mortality, and incidence of cardiovascular diseases from pooled data of Chinese cohorts. Methods The prospective study data of existing cohort studies in China were collected, and the age-adjusted all-cause mortality stratified by BMI were estimated. The similar analysis was repeated after excluding deaths within the first three years of follow-up and after excluding smokers. The incidence of age-adjusted coronary heart disease (CHD) and stroke stratified by BMI were also analyzed. Multiple Cox regression coefficients of BMI for the incidence of CHD and stroke after controlling other risk factors were pooled utilizing the methods of weighting by inverse of variance to reveal whether BMI had independent effect and its strength on the incidence of CHD and stroke. Results The data of 4 cohorts including 76 227persons, with 745 346 person-years of follow-up were collected and analyzed. The age-adjusted allcause mortality stratified by BMI showed a U-shaped curve, even after excluding deaths within the first three years of follow-up and excluding smokers. Age-adjusted all-cause mortality increased when BMI was lower than 18.5 and higher than 28. The incidence of CHD and stroke, especially ishemic stroke increased with increasing BMI, this was consistent with parallel increasing of risk factors. Cox regression analysis showed that BMI was an independent risk factor for both CHD and stroke. Each amount of 2 kg/m2 increase in baseline BMI might cause 15.4%, 6.1% and 18.8 % increase in relative risk of CHD, total stroke and ischemic stroke. Reduction of BMI to under 24 might prevent the incidence of CHD by 11% and that of stroke by15 % for men, and 22 % of both diseases for women. Conclusion BMI ≤18.5, 24-27.9 and ≥28 (kg/m2) is the appropriate cut-off points for underweight, overweight and obesity in

  17. Medium Cut-Off (MCO) Membranes Reduce Inflammation in Chronic Dialysis Patients—A Randomized Controlled Clinical Trial

    Science.gov (United States)

    Zickler, Daniel; Schindler, Ralf; Willy, Kevin; Martus, Peter; Pawlak, Michael; Storr, Markus; Hulko, Michael; Boehler, Torsten; Glomb, Marcus A.; Liehr, Kristin; Henning, Christian; Templin, Markus; Trojanowicz, Bogusz; Ulrich, Christof; Werner, Kristin; Fiedler, Roman; Girndt, Matthias

    2017-01-01

    Background To increase the removal of middle-sized uremic toxins a new membrane with enhanced permeability and selectivity, called Medium Cut-Off membrane (MCO-Ci) has been developed that at the same time ensures the retention of albumin. Because many middle-sized substances may contribute to micro-inflammation we hypothesized that the use of MCO-Ci influences the inflammatory state in hemodialysis patients. Methods The randomized crossover trial in 48 patients compared MCO-Ci dialysis to High-flux dialysis of 4 weeks duration each plus 8 weeks extension phase. Primary endpoint was the gene expression of TNF-α and IL-6 in peripheral blood mononuclear cells (PBMCs), secondary endpoints were plasma levels of specified inflammatory mediators and cytokines. Results After four weeks of MCO-Ci the expression of TNF-α mRNA (Relative quantification (RQ) from 0.92 ± 0.34 to 0.75 ± 0.31, -18.5%, pkappa and lambda free light chains, urea and an increase for Lp-PLA2 (PLA2G7) compared to High-flux. Albumin levels dropped significantly after 4 weeks of MCO dialysis but increased after additional 8 weeks of MCO dialysis. Twelve weeks treatment with MCO-Ci was well tolerated regarding the number of (S)AEs. In the extension period levels of CRP, TNF-α-mRNA and IL-6 mRNA remained stable in High-flux as well as in MCO-Ci. Conclusions MCO-Ci dialyzers modulate inflammation in chronic HD patients to a greater extent compared to High-flux dialyzers. Transcription of pro-inflammatory cytokines in peripheral leukocytes is markedly reduced and removal of soluble mediators is enhanced with MCO dialysis. Serum albumin concentrations stabilize after an initial drop. These results encourage further trials with longer treatment periods and clinical endpoints. PMID:28085888

  18. High-speed video of competing and cut-off leaders prior to "upward illumination-type" lightning ground strokes

    Science.gov (United States)

    Stolzenburg, Maribeth; Marshall, Thomas; Karunarathne, Sumedhe; Karunarathna, Nadeeka; Warner, Tom; Orville, Richard

    2013-04-01

    This study presents evidence to test a hypothesis regarding the physical mechanism resulting in very weak "upward illumination" (UI) type ground strokes occurring within a few milliseconds after a normal return stroke (RS) of a negative lightning flash. As described in previous work [Stolzenburg et al., JGR D15203, 2012], these short duration (strokes form a new ground connection, without apparent connection to the main RS, over their relatively short (return path. From a dataset of 170 video flashes acquired in 2011 (captured at 50000 frames per second), we find 20 good UI examples in 18 flashes at 2.5-32.3 km distance from the camera. Average separation values are 1.26 ms and 1.9 km between the ground connections of the UI and main RS. Based on electric field change data for the flashes, the estimated peak current of the UI strokes averages -5.0 kA, about one-third the average value for the preceding RS. In 15 cases the video data show a distinct stepped leader to the UI which develops concurrently with the stepped leader to the main RS. Estimated altitude of the UI leader tip just before the main RS occurs ranges from 0 to 610 m, and in 7 cases steps are visible in the UI leader after the main RS. In most of the examples the RS and UI appear as separate channels for their entire visible portion, but in 5 cases there is a junction indicating the UI leader is a cut-off branch from the main leader. A generalized schematic of the seven main luminosity stages in a typical UI, along with video examples showing each of these stages and electric field change data, will be presented.

  19. Combined Effect of an Atmospheric River and a Cut-off Low in Hiroshima Flooding Event on August 19, 2014

    Science.gov (United States)

    Takayabu, Y. N.; Hirota, N.; Kato, M.; Arakane, S.

    2015-12-01

    An extraordinary precipitation over 100 mmhr-1in Hiroshima on August 19, 2014, caused a flash flood which resulted in 74 fatalities and collapse of 330 houses. In order to examine the meteorological background of this flooding event, we carried out a detailed analysis utilizing rain gauge data, satellite precipitation dataset, and a meso scale and a global scale objective analyses provided from the Japan Meteorological Agency. Then, we performed numerical experiments using a nonhydrostatic compressible equation model called the Cloud-Resolving Storm Simulator (CReSS). As a result, a combined effect of an atmospheric river (AR) and a cut-off low (COL) in this flooding event was elucidated. During the event, a filamentary transport of moisture extending from the Indochina Peninsula to the Japanese Islands was observed along the southern side of the subtropical jet, forming an AR. This AR had a deep structure with an amount of free tropospheric moisture comparable to that of the boundary layer. Concurrently, there was a COL, detached from the Mid-Pacific Trough, moving northwestward toward the Japanese Archipelago. With various sensitivity experiments, we concluded that a mid-tropospheric instability associated with the cold core of the COL and a dynamical ascent induced in its foreside, collaboratively worked with the anomalous moisture in the free troposphere associated with the AR, to extraordinarily enhance the precipitation over Hiroshima region. An orographic effect to concentrate the precipitation in this region was also confirmed. An implication on a difference in effects of AR in this event with a climatologically moist boundary layer, from those in the US west coast with a very dry environment, was also obtained. Acknowledgment: This study is supported by the Environment Research and Technology Development Fund (2-1503) of the Ministry of the Environment, Japan, and by the Ministry of Education, Culture, Sports, Science and Technology, Japan.

  20. Cut-off value of FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction in a Korean population

    Directory of Open Access Journals (Sweden)

    Chung KS

    2016-08-01

    Full Text Available Kyung Soo Chung,1,2 Ji Ye Jung,1,2 Moo Suk Park,1,2 Young Sam Kim,1,2 Se Kyu Kim,1,2 Joon Chang,1,2 Joo Han Song1,2 1Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; 2Institute of Chest Disease, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea Background: Forced expiratory volume in 1 second (FEV1/forced expiratory volume in 6 seconds (FEV6 has been proposed as an alternative to FEV1/forced vital capacity (FVC for detecting airway obstruction. A fixed cut-off value for FEV1/FEV6 in a Korean population is lacking. We investigated a fixed cut-off for FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction.Materials and methods: We used data obtained in the 5 years of the Fifth and Sixth Korean National Health and Nutrition Examination Survey. A total of 14,978 participants aged ≥40 years who underwent spirometry adequately were the study cohort. “Airway obstruction” was a fixed cut-off FEV1/FVC <70% according to the Global Initiative for Chronic Obstructive Lung Disease guidelines. We also used European Respiratory Society/Global Lung Initiative 2012 equations for the FEV1/FVC lower limit of normal.Results: Among the 14,978 participants (43.5% male, 56.5% female; mean age: 56.9 years for men and 57.0 years for women, 14.0% had obstructive lung function according to a fixed cut-off FEV1/FVC <70%. Optimal FEV1/FEV6 cut-off for predicting FEV1/FVC <70% was 75% using receiver operating characteristic curve analyses (area under receiver operating characteristic curve =0.989, 95% confidence interval 0.987–0.990. This fixed cut-off of FEV1/FEV6 showed 93.8% sensitivity, 94.8% specificity, 74.7% positive predictive value, 98.9% negative predictive value, and 0.8 Cohen’s kappa coefficient. When compared with FEV1/FVC < lower limit of normal, FEV1/FEV6 <75% tended to over-diagnose airflow limitation (just like a fixed cut-off

  1. Criteria to interpret cancer biomarker increments crossing the recommended cut-off compared in a simulation model focusing on false positive signals and tumour detection time

    DEFF Research Database (Denmark)

    Lund, Flemming; Hyltoft Petersen, Per; Pedersen, Merete Frejstrup;

    2014-01-01

    BACKGROUND: Several criteria have been proposed to interpret increments in serological cancer biomarker concentrations starting from low baseline concentrations crossing the cut-off. None of the criteria have been compared for their ability to signal tumour growth when ≤2% false positive results...... are accepted. METHODS: The cancer biomarker Tissue Polypeptide Antigen was used as an example. Seven criteria to interpret increments in concentrations were investigated by computer simulations. Firstly, for each criterion, we identified a baseline concentration stratified for three levels of biological...... that different types of criteria should be used within different intervals of below cut-off level concentrations if the rate of false positive signals of marker increments should be kept ≤2%....

  2. A cautionary note about the cross-national and clinical validity of cut-off points for the Maslach Burnout Inventory.

    Science.gov (United States)

    Schaufeli, W B; Van Dierendonck, D

    1995-06-01

    In the present study, burnout scores of three samples, as measured with the Maslach Burnout Inventory, were compared: (1) the normative American sample from the test-manual (N = 10,067), (2) the normative Dutch sample (N = 3,892), and (3) a Dutch outpatient sample (N = 142). Generally, the highest burnout scores were found for the outpatient sample, followed by the American and Dutch normative samples, respectively. Slightly different patterns were noted for each of the three components. Probably sampling bias, i.e., the healthy worker effect, or cultural value patterns, i.e., femininity versus masculinity, might be responsible for the results. It is concluded that extreme caution is required when cut-off points are used to classify individuals by burnout scores; only nation-specific and clinically derived cut-off points should be employed.

  3. Determining cut-off values for neck circumference as a measure of the metabolic syndrome amongst a South African cohort: the SABPA study

    OpenAIRE

    Hoebel, Svelka; Malan, Leone; Van Ridder, Johannes Hendrik

    2012-01-01

    The aim was to determine receiver operating characteristic (ROC) neck circumference (NC) cut offs best associated with the metabolic syndrome (MetS) in a South African cohort. We included 409 urban Africans and Caucasians and stratified them into gender and age groups (25–45 years; 45–65 years). Measurements included anthropometric, fasting overnight urine and biological markers for the MetS (systolic and diastolic blood pressure, glucose, triglycerides, and high density lipoprotein). ROC ana...

  4. Cut-off points for mild, moderate, and severe pain on the visual analogue scale for pain in patients with chronic musculoskeletal pain.

    Science.gov (United States)

    Boonstra, Anne M; Schiphorst Preuper, Henrica R; Balk, Gerlof A; Stewart, Roy E

    2014-12-01

    The aim of this study was to find the cut-off points on the visual analogue scale (VAS) to distinguish among mild, moderate, and severe pain, in relation to the following: pain-related interference with functioning; verbal description of the VAS scores; and latent class analysis for patients with chronic musculoskeletal pain. A total of 456 patients were included. Pain was assessed using the VAS and verbal rating scale; functioning was assessed using the domains of the Short Form (36) Health Survey (SF-36). Eight cut-off point schemes were tested using multivariate analysis of variance (MANOVA), ordinal logistic regression, and latent class analysis. The study results showed that VAS scores ⩽ 3.4 corresponded to mild interference with functioning, whereas 3.5 to 6.4 implied moderate interference, and ⩾ 6.5 implied severe interference. VAS scores ⩽ 3.4 were best described for patients with chronic musculoskeletal pain as mild pain, 3.5 to 7.4 as moderate pain, and ⩾ 7.5 as severe pain. Latent class analysis found that a 3-class solution fitted best, resulting in the classes 0.1 to 3.8, 3.9 to 5.7, and 5.8 to 10 cm. Findings from our study agree with those of some other studies, although many other studies found different optimal cut-off point schemes. As there appear to be no universally accepted cut-off points, and in view of the low-to-moderate associations between VAS scores and functioning and between VAS and verbal rating scale scores, the correct classification of VAS scores as mild, moderate. or severe in clinical practice seems doubtful.

  5. Prediction of subacute infarct lesion volumes by processing apparent diffusion coefficient maps based on apparent diffusion coefficient cut-off values in patients with acute stroke

    Institute of Scientific and Technical Information of China (English)

    郭翔

    2014-01-01

    Objective To explore the feasibility of prediction of subacute infarct lesion volumes by processing ADC maps based on ADC cut-off values in patients with acute stroke.Methods MRI was performed in 20 patients with clinically diagnosed acute infarct less than 6 h after stroke onset.The MRI included a DWI and conventional MRI.The follow-up MR examinations of all the patients

  6. Cerebrospinal fluid neopterin analysis in neuropediatric patients: establishment of a new cut off-value for the identification of inflammatory-immune mediated processes.

    Directory of Open Access Journals (Sweden)

    Marta Molero-Luis

    Full Text Available OBJECTIVE: A high level of cerebrospinal fluid (CSF neopterin is a marker of central nervous system inflammatory-immune mediated processes. We aimed to assess data from 606 neuropediatric patients, describing the clinical and biochemical features of those neurological disorders presenting CSF neopterin values above a new cut-off value that was defined in our laboratory. METHODS: To establish the new CSF neopterin cut-off value, we studied two groups of patients: Group 1 comprised 68 patients with meningoencephalitis, and Group 2 comprised 52 children with a confirmed peripheral infection and no central nervous system involvement. We studied 606 CSF samples from neuropediatric patients who were classified into 3 groups: genetic diagnosis (A, acquired/unknown etiologic neurologic diseases (B and inflammatory-immune mediated processes (C. RESULTS: The CSF neopterin cut-off value was 61 nmol/L. Out of 606 cases, 56 presented a CSF neopterin level above this value. Group C had significantly higher CSF neopterin, protein and leukocyte values than the other groups. Sixteen of twenty-three patients in this group had a CSF neopterin level above the cut-off, whereas three and seven patients presented increased leukocyte and protein values, respectively. A significant association was found among CSF neopterin, proteins and leukocytes in the 606 patients. White matter disturbances were associated with high CSF neopterin concentrations. CONCLUSIONS: Although children with inflammatory-immune mediated processes presented higher CSF neopterin values, patients with other neurological disorders also showed increased CSF neopterin concentrations. These results stress the importance of CSF neopterin analysis for the identification of inflammatory-immune mediated processes.

  7. Changes in D-dimer and inflammatory biomarkers before ischemic events in patients with peripheral artery disease: The BRAVO Study.

    Science.gov (United States)

    McDermott, Mary McGrae; Liu, Kiang; Green, David; Greenland, Philip; Tian, Lu; Kibbe, Melina; Tracy, Russell; Shah, Sanjiv; Wilkins, John T; Huffman, Mark; Zhao, Lihui; Huang, Chiang-Ching; Auerbach, Amanda; Liao, Yihua; Skelly, Christopher L; McCarthy, Walter; Lloyd Jones, Donald

    2016-02-01

    Whether circulating biomarker levels increase shortly before an ischemic heart disease (IHD) event is unknown. We studied whether levels of D-dimer, C-reactive protein (CRP), and serum amyloid A (SAA) are higher within 2 months of an IHD event compared to time periods more than 2 months before the IHD event. We assembled 595 participants with peripheral artery disease (PAD) and followed them for up to 3 years. Blood samples were obtained every 2 months. The primary outcome was IHD events: myocardial infarctions, unstable angina, or IHD death. We used a nested case-control design. Fifty participants (cases) had events and were each matched by age, sex, duration in the study, and number of blood draws to two controls without events. Among cases, the mean D-dimer value of 1.105 obtained within 2 months of the event was higher than values obtained 10 months (0.68 mg/L, pevent. Compared to controls, median D-dimer levels in cases were higher 4 months (p=0.017), 6 months (p=0.005), and 8 months (p=0.028) before the event. Values of CRP and SAA obtained within two months of an IHD event not consistently higher than values obtained during the prior months. In PAD participants with an IHD event, D-dimer was higher within 2 months of the event, compared to most values obtained 10 to 32 months previously. D-dimer was also higher in cases as compared to controls during most visits within 8 months of the IHD event.

  8. Plasma level of D-dimer accompanying different types of gynecologic surgery and effects of prophylactic subcutaneous injection of heparin calcium

    Directory of Open Access Journals (Sweden)

    Sakika Yanai

    2015-06-01

    Conclusions: Plasma levels of D-dimer on POD-1 were higher than those on the DPE in each type of gynecologic surgery. The D-dimer level remained high even on POD-6, and not changed by prophylactic subcutaneous injection of heparin calcium. [Int J Reprod Contracept Obstet Gynecol 2015; 4(3.000: 551-554

  9. Advances in the clinical application of high cut-off hemodialysis%高截留量血液透析临床应用进展

    Institute of Scientific and Technical Information of China (English)

    邬步云

    2012-01-01

    高截留量膜最初用于清除严重脓毒症的炎症介质,近年来被用于治疗骨髓瘤管型肾病、横纹肌溶解等疾病,并有望用于终末期肾病患者大分子毒素的清除.本文就高截留量膜的定义、理论基础、高截留量血液透析相关技术及临床应用进展作一简述.%Initially designed to remove the inflamamatory mediators in the patients with severe sepsis,high cut-off membranes have being applicated in the treatment of myeloma kidney and rhabdomyolysis. Furthermore, high cut-off membranes have a potential for the removal of uremic toxins with large molecules in the patients with .end-stage renal disease. This review is to summarize the definition, rational, techniques and advancement in the clinical application of high cut-off membranes.

  10. Optimal Elasticity cut-off value for discriminating Healthy to Pathological Fibrotic patients employing Fuzzy C-Means automatic segmentation in Liver Shear Wave Elastography images

    Science.gov (United States)

    Gatos, Ilias; Tsantis, Stavros; Skouroliakou, Aikaterini; Theotokas, Ioannis; Zoumpoulis, Pavlos S.; Kagadis, George C.

    2015-09-01

    The aim of the present study is to determine an optimal elasticity cut-off value for discriminating Healthy from Pathological fibrotic patients by means of Fuzzy C-Means automatic segmentation and maximum participation cluster mean value employment in Shear Wave Elastography (SWE) images. The clinical dataset comprised 32 subjects (16 Healthy and 16 histological or Fibroscan verified Chronic Liver Disease). An experienced Radiologist performed SWE measurement placing a region of interest (ROI) on each subject's right liver lobe providing a SWE image for each patient. Subsequently Fuzzy C-Means clustering was performed on every SWE image utilizing 5 clusters. Mean Stiffness value and pixels number of each cluster were calculated. The mean stiffness value feature of the cluster with maximum pixels number was then fed as input for ROC analysis. The selected Mean Stiffness value feature an Area Under the Curve (AUC) of 0.8633 with Optimum Cut-off value of 7.5 kPa with sensitivity and specificity values of 0.8438 and 0.875 and balanced accuracy of 0.8594. Examiner's classification measurements exhibited sensitivity, specificity and balanced accuracy value of 0.8125 with 7.1 kPa cutoff value. A new promising automatic algorithm was implemented with more objective criteria of defining optimum elasticity cut-off values for discriminating fibrosis stages for SWE. More subjects are needed in order to define if this algorithm is an objective tool to outperform manual ROI selection.

  11. Improving Screening Cut-Off Scores for DSM-5 Adolescent Anxiety Disorder Symptom Dimensions with the Screen for Child Anxiety Related Emotional Disorders

    Directory of Open Access Journals (Sweden)

    William W. Hale III

    2014-01-01

    Full Text Available Presently most adolescent anxiety disorder screening instruments make their determination of running a high risk for an anxiety disorder on the basis of a cut-off score measured by a single screening which can lead to false positives. Therefore, the goal of this study is to examine whether a repeated administration of the SCARED screening instrument for DSM-5 anxiety disorder symptoms could help in the detection of true positives while also avoiding false positives. Participants were 923 early adolescents from the general community. The adolescents’ ages at the first annual screening ranged from 10 to 15 with an average of 12.5 years. In a prospective five-year longitudinal design, the adolescents completed the SCARED screening instrument for anxiety disorder symptoms on a yearly basis. To detect true positives and avoid false positives, the data were analyzed with Receiver Operating Characteristics (ROC cut-off score analyses. ROC cut-off score analyses revealed that the sensitivity and specificity of high risk were greatly improved for repeated screenings above those of a single screening. The findings of this study demonstrate that a screening instrument (such as the SCARED should be administered not just once but several times in order to better determine true positives and avoid false positives.

  12. Prevalence of body mass index and body weight cut-off points for in vitro fertilization treatment at U.S. clinics and current clinic weight loss strategy recommendations.

    Science.gov (United States)

    Turner-McGrievy, Gabrielle M; Grant, Breănna L

    2015-09-01

    The goal of this study was to determine how many clinics providing in vitro fertilization (IVF) in the United States require a body mass index (BMI) or body weight cut-off point to determine treatment eligibility. US clinics listed as members on the Society of Assisted Reproduction website in late 2013 were contacted by phone between January and March 2014. Clinic personnel were asked if a BMI or body weight cut-off points was used to determine IVF treatment eligibility and what strategies they recommended for their patients to achieve a healthy body weight. Of the 379 clinics contacted, 347 responded (92% response rate) and 35% (n = 120) reported using a BMI or body weight cut-off points to determine eligibility for IVF treatment. Mean BMI (± SD) cut-off points was 38.4 ± 5.2 kg/m(2) and mean body weight (± SD) cut-off points was 130.2 ± 14.8 kg. Of the clinics using a set cut-off points, half (46%) provided no weight loss recommendations for patients. A sizable portion of US IVF clinics report a required or preferred BMI or body weight cut-off points for treatment. Despite this, most clinics did not provide a recommended program or approach for weight loss with very few clinics reporting an in-house program.

  13. Further performance evaluation of 5.3 μm cut-off Hawaii-2RG detectors

    Science.gov (United States)

    Ives, Derek; Beckmann, Udo; Alvarez, Domingo; Finger, Gert; Geimer, Christoph; Heininger, Matthias; Mehrgan, Leander; Tulloch, Simon

    2016-07-01

    ESO has now delivered or tested in-house, four new 5.3 μm cut-off H2RG detectors, for various projects, such as MATISSE for the VLTI and the upgrade project for CRIRES, the cryogenic high-resolution infrared echelle spectrograph for the VLT. The specified instruments have required the implementation of some of the more unusual read out options for these detectors, which may have already been used by other groups, for example, the line-reset-read and line-read-reset modes rather than the standard global reset mode. The detectors are also offered with both output speed options, that is, the standard slow, low noise readout and the faster, higher noise readout, where > 10 frames/s are possible. In the process of building these detector systems and implementing these new options we have delved deeper into some of the lesser known features of these detectors and tried to characterize them more fully. It is important that these characteristics are well understood before delivery of the next generation of detectors for the ELTs where high speed and windowing options are required. We obtain very good performance at 2 Mpixel/s pixel speeds with less than 40 e- rms read noise, in all other aspects such as linearity, noise versus number of non-destructive reads and cross talk then the performance of the outputs is the same as slow speed operation. However, the high speed output stages are quite complex to operate, they need to be very well tuned and are prone to oscillation, if not set correctly. We will report on the best bias options to optimize their performance. Some stability issues are also seen with the slow outputs and this is also reported. Likewise we have observed differences between global reset and line reset for the detectors, manifested in a significant increase in detector full well for the line reset option, this also will be reported on. We have also determined that there may be signal induced by the detector readout clocking process for certain detector

  14. Determining a Cut-Off Point for Scores of the Breastfeeding Self-Efficacy Scale-Short Form: Secondary Data Analysis of an Intervention Study in Japan.

    Directory of Open Access Journals (Sweden)

    Keiko Nanishi

    Full Text Available Breastfeeding self-efficacy can be measured with the Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF. Mothers with low BSES-SF scores stop exclusive breastfeeding prematurely, but specific interventions can prevent that undesirable outcome. Because those interventions can be expensive, often one must decide which mothers will receive them. For that purpose, a cut-off BSES-SF score would be useful, but none is available. Therefore, we aimed to assess the overall accuracy of BSES-SF scores as predictors of not practicing post-discharge exclusive breastfeeding, and to choose an appropriate cut-off score for making that prediction.This is a secondary data analysis of an intervention study. Data from 378 women in two non-Baby-Friendly Hospitals were analyzed. Participants were women in their third trimester who were 16 years of age or older, were able to read and write Japanese, were expected to have a singleton birth, and had completed the BSES-SF before discharge. BSES-SF scores were measured before discharge. Breastfeeding status was assessed 4 weeks and 12 weeks postpartum. Receiver Operating Characteristic (ROC curves were used to assess the predictive ability of the BSES-SF and to inform the choice of a cut-off point.For both of the ROC curves (4 and 12 weeks postpartum the area under the curve was 0.74. To obtain a high sensitivity, a cut-off score of 50 was chosen. With that cut-off score the sensitivity was 79% and the specificity was 52% 4 weeks postpartum, and they were 77% and 52%, respectively, 12 weeks postpartum.In conclusion, the BSES-SF has moderate overall accuracy to distinguish women who will not practice exclusive breastfeeding after discharge from those who will. At non-Baby-Friendly hospitals in Japan, interventions to support exclusive breastfeeding might be considered for new mothers who have BSES-SF scores that are less than or equal to 50.

  15. Increased tissue factor, MMP-8, and D-dimer expression in diabetic patients with unstable advanced carotid atherosclerosis

    Directory of Open Access Journals (Sweden)

    Jerzy Krupinski

    2007-09-01

    Full Text Available Jerzy Krupinski1,2, Marta M Turu1,2, M Angels Font1, Nesser Ahmed3, Matthew Sullivan3, Ana Luque1,2, Francisco Rubio1, Lina Badimon2, Mark Slevin31Department of Neurology, Stroke Unit, University Hospital of Bellvitge (HUB, Fundacio IDIBELL, Barcelona, Spain; 2Cardiovascular Research Centre, IIBB/CSIC-HSCSP-UAB, Barcelona, Spain; 3School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, United KingdomAbstract: Advanced atherogenesis is characterized by the presence of markers of enhanced prothrombotic capacity, attenuated fibrinolysis, and by clinical conditions associated with defective coagulation. Diabetes may be associated with enhanced lesion instability and atherosclerotic plaque rupture. Plaques obtained from 206 patients undergoing carotid endarterectomy were divided into diabetic (type 2 and nondiabetic and analyzed by Western blotting and immunohistochemistry to detect tissue factor (TF, metalloproteinases (MMP-2, -8, -9, and fibrin/fibrinogen related antigens, and in situ zymography to detect MMP activity. Plasma samples were quantified for TF procoagulant activity, C-reactive protein, fibrinogen and D-dimer. Diabetic and symptomatic patients with hypoechogenic plaques had increased plasma TF activity and D-dimer, compared with those with hyperechogenic plaques (p = 0.03, p = 0.007, respectively. Diabetic, symptomatic patients had higher plasma D-dimer levels than asymptomatic patients (p = 0.03. There was a significant correlation between intramural TF levels and D-dimer in diabetic patients with symptomatic disease (p = 0.001, r2 = 0.4. In diabetic patients, plasma fibrinogen levels were higher in patients with hypoechogenic plaques (p = 0.007. Diabetic patients with ulcerated plaques had higher plasma D-dimer and MMP-8 levels than those with fibrous plaques (p = 0.02, p = 0.01, respectively. This data suggests that currently available circulating markers may be clinically useful to select

  16. A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study

    Directory of Open Access Journals (Sweden)

    V. P. Diego

    2010-01-01

    D-dimer levels were normalized in our study. We found that D-dimer levels were heritable, at about 23% heritability (P≈.00001. In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM. We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM. Conclusions. To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. These results warrant further investigation.

  17. The role of serum D-dimer level in the diagnosis of patients admitted to the emergency department complaining of chest pain.

    Science.gov (United States)

    Orak, M; Ustündağ, M; Güloğlu, C; Alyan, O; Sayhan, M B

    2010-01-01

    This study investigated D-dimer levels in 241 patients admitted to the emergency department with sudden-onset chest pain. The patient group included those diagnosed with acute coronary syndrome (ACS; i.e., unstable angina pectoris [USAP], non-ST elevated myocardial infarction [NSTEMI], ST-elevated myocardial infarction [STEMI]); the control group included those diagnosed with non-cardiac chest pain. Mean serum levels of D-dimer, creatine kinase-MB (CK-MB) and troponin I (TPI) were compared between the groups. Levels of D-dimer, CK-MB and TPI in the patient group were significantly higher than in the control group. There were also significantly higher D-dimer, CK-MB and TPI levels in the STEMI and NSTEMI patient subgroups compared with the control group. Only the D-dimer level was significantly higher in the USAP subgroup versus the control group. The sensitivity and specificity of D-dimer for ACS were 83.7% and 95.4%, respectively, suggesting that evaluating D-dimer levels might be useful in the emergency room for diagnosing ACS and predicting mortality in patients presenting with acute chest pain.

  18. Predictive value of D-dimer for portal vein thrombosis after portal hypertension surgery in hepatitis B virus-related cirrhosis

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    AIM: To evaluate the predictive value of D-dimer as a predictive indicator of portal vein thrombosis (PVT) after portal hypertension surgery in hepatitis B virus-related cirrhosis.METHODS: A prospective study was carried out in 52 patients who had undergone surgery for portal hypertension in hepatitis B virus-related cirrhosis.Changes in perioperative dynamic D-dimer were observed. The sensitivity, specificity, positive predictive values and negative predictive values of D-dimer were calculated, and ROC curves were analyzed.RESULTS: The D-dimer levels in the group developing postoperative PVT was significantly higher than those in the group not developing PVT (P = 0.001), and the ROC semi-quantitative and qualitative analysis of D-dimer showed a moderate predictive value in PVT (semiquantitative value Az = 0.794, P = 0.000; qualitative analysis: Az = 0.739, P = 0.001).CONCLUSION: Dynamic monitoring of D-dimer levels in patients with portal hypertension after surgery can help early diagnosis of PVT, as in cases where the D-dimer levels steadily increase and exceed 16 μg/mL, the possibility of PVT is very high.

  19. The Sensitivity and Specificity of High Sensitive CRP, D-Dimer and IL-6 in Acute Coronary Syndrome

    Directory of Open Access Journals (Sweden)

    Özlem Yiğit

    2011-11-01

    Full Text Available Objective: ACS is the life threatening causes of chest pain. The aim of this study is to detect the sensitivity and specificity of CRP, IL-6 and D-dimer and identify their role in predicting adverse cardiac events. Material and Methods: All patients describing typical chest pain were enrolled in the study. Demographic features and final diagnosis were written and serum specimens were collected. All patients were telephoned after one month to determine if there were any adverse cardiac events. Results: There were 132 patients, (94 male, 38 female. The mean age was 60.92±10.78. 55 patients were diagnosed as AMI (37 STEMI and 18 NSTEMI 60 patients as unstable angina pectoris, 15 patients as stable angina pectoris and 2 patients as non cardiac chest pain. 6 patients died in the hospital. 15 patients had adverse cardiac events (12 recurrent AMI, 2 sudden cardiac death, 1 stroke. The levels of D-dimer, CRP and IL-6 at the presentation were not predictive for adverse events. Conclusion: D-dimer, CRP and IL-6 levels were high both in ACS and stable angina. Detecting the predictive value for adverse cardiac events requires larger patient numbers and longer follow up times.

  20. Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China

    Institute of Scientific and Technical Information of China (English)

    ZHOU Hai Cheng; TIAN Hao Ming; JI Qiu He; ZHU Da Long; CHEN Li; GUO Xiao Hui; ZHAO Zhi Gang; Li Qiang; ZHOU Zhi Guang; GE Jia Pu; SHAN Guang Liang; LAI Ya Xin; SHAN Zhong Yan; JIA Wei Ping; YANG Wen Ying; LU Ju Ming; WENG Jian Ping; JI Li Nong; LIU Jie

    2014-01-01

    Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome (MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces (autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation (IDF) criteria and modified IDF criteria. Results The age-standardized prevalence of MetS was 24.2%(22.1%in men and 25.8%in women) and 19.5% (22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6%in men and 7.8%in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity (90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China.

  1. Bovine Tuberculosis in Cattle in the Highlands of Cameroon: Seroprevalence Estimates and Rates of Tuberculin Skin Test Reactors at Modified Cut-Offs

    Directory of Open Access Journals (Sweden)

    J. Awah-Ndukum

    2012-01-01

    Full Text Available The aim of this study was to obtain epidemiological estimates of bovine tuberculosis (TB prevalence in cattle in the highlands of Cameroon using two population-based tuberculin skin test (TST surveys in the years 2009 and 2010. However, prior to the TST survey in 2010, blood was collected from already chosen cattle for serological assay. Anti-bovine TB antibodies was detected in 37.17% of tested animals and bovine TB prevalence estimates were 3.59%–7.48%, 8.92%–13.25%, 11.77%–17.26% and 13.14%–18.35% for comparative TST at ≥4 mm, ≥3 mm and ≥2 mm cut-off points and single TST, respectively. The agreement between TST and lateral flow was generally higher in TST positive than in TST negative subjects. The K coefficients were 0.119, 0.234, 0.251 and 0.254 for comparative TST at ≥4 mm, ≥3 mm and ≥2 mm cut-off points and the single TST groups, respectively. Chi square statistics revealed that strong (P48 associations existed between seroprevalence rates and TST reactors. The study suggested that using lateral flow assay and TST at severe interpretations could improve the perception of bovine TB in Cameroon. The importance of defining TST at modified cut-offs and disease status by post-mortem detection and mycobacterial culture of TB lesions in local environments cannot be overemphasised.

  2. Raising cut-off value of prostate specific antigen (PSA for biopsy in symptomatic men in India to reduce unnecessary biopsy

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    Shalini Agnihotri

    2014-01-01

    Full Text Available Background & objectives: The characteristics of prostate specific antigen (PSA for trans-rectal ultrasonography guided prostate biopsy in men with lower urinary tract symptoms (LUTS are not well defined. This study was carried out to analyse the threshold of PSA for biopsy in symptomatic men in India. Methods: From January 2000 to June 2011, consecutive patients who had digital rectal examination (DRE and PSA testing done for LUTS were included in this study. PSA was done with ELISA technique. Patients with acute or chronic prostatitis, prostatic abscess, history of surgery on prostate within the previous three months and patients on 5α-reductase inhibitors or on urethral catheter were excluded. Results: Of the 4702 patients evaluated, 70.9 per cent had PSA of less than 4 ng/ml and 29.1 per cent had PSA of more than 4 ng/ml. Of these, 875 men with a mean age of 65.72±7.4 (range 50-75 yr had trans rectal ultrasonography (TRUS guided biopsy. Twenty five men had biopsy at PSA level of 20 ng/ml. Positive predictive value of PSA in ranges of 4.1-10, 10.1-20, >20 ng/ml was 15.2, 24 and 62.6 per cent, respectively with negative DRE. PSA cut-off to do biopsy was derived by ROC curve as 5.82 ng/ml for all the men. When the subjects were further stratified on the basis of DRE findings, a cut-off of 5.4 ng/ml was derived in men with normal DRE. Interpretation & conclusions: A cut-off for biopsy in symptomatic men with negative DRE could safely be raised to 5.4 ng/ml, which could avoid subjecting 10 per cent of men to undergo unnecessary biopsy.

  3. Using a 3% Proton Density Fat Fraction as a Cut-off Value Increases Sensitivity of Detection of Hepatic Steatosis, Based on Results from Histopathology Analysis.

    Science.gov (United States)

    Nasr, Patrik; Forsgren, Mikael F; Ignatova, Simone; Dahlström, Nils; Cedersund, Gunnar; Leinhard, Olof Dahlqvist; Norén, Bengt; Ekstedt, Mattias; Lundberg, Peter; Kechagias, Stergios

    2017-03-09

    It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy ((1)H-MRS), instead of collecting and analyzing liver biopsies to detect steatosis. However, the current PDFF cut-off value (5%) used to define steatosis by magnetic resonance was derived from studies that did not use histopathology as the reference standard. We performed a prospective study to determine the accuracy of (1)H-MRS PDFF in measurement of steatosis using histopathology analysis as the standard. We collected clinical, serologic, (1)H-MRS PDFF, and liver biopsy data from 94 adult patients with increased levels of liver enzymes (6 months or more) referred to the Department of Gastroenterology and Hepatology at Linköping University Hospital in Sweden from 2007 through 2014. Steatosis was graded using the conventional histopathology method and fat content was quantified in biopsy samples using stereological point counts (SPCs). We correlated (1)H-MRS PDFF findings with SPCs (r = 0.92; P <.001). (1)H-MRS PDFF results correlated with histopathology results (ρ = 0.87; P <.001), and SPCs correlated with histopathology results (ρ = 0.88; P <.001). All 25 subjects with PDFF values of 5.0% or more had steatosis based on histopathology findings (100% specificity for PDFF). However, of 69 subjects with PDFF values below 5.0% (negative result), 22 were determined to have steatosis based on histopathology findings (53% sensitivity for PDFF). Reducing the PDFF cut-off value to 3.0% identified patients with steatosis with 100% specificity and 79% sensitivity; a PDFF cut-off value of 2.0% identified patients with steatosis with 94% specificity and 87% sensitivity. These findings might be used to improve non-invasive detection of steatosis.

  4. Optimal cut-off criteria for duplex ultrasound for the diagnosis of restenosis in stented carotid arteries: Review and protocol for a diagnostic study

    Directory of Open Access Journals (Sweden)

    Brown Martin M

    2009-07-01

    Full Text Available Abstract Background Carotid angioplasty with stenting is a relatively new, increasingly used, less-invasive treatment for the treatment of symptomatic carotid artery stenosis. It is being evaluated in ongoing and nearly finished randomized trials. An important factor in the evaluation of stents is the occurrence of in-stent restenosis. An un-stented carotid artery is likely to have a more elastic vessel wall than a stented one, even if stenosis is present. Therefore, duplex ultrasound cut-off criteria for the degrees of an in-stent stenosis, based on blood velocity parameters, are probably different from the established cut-offs used for un-stented arteries. Routine criteria can not be applied to stented arteries but new criteria need to be established for this particular purpose. Methods/Design Current literature was systematically reviewed. From the selected studies, the following data were extracted: publication year, population size, whether the study was prospective, duplex ultrasound cut-off criteria reported, which reference test was used, and if there was an indication for selection bias and for verification bias in particular. Previous studies often were retrospective, or the reference test (DSA or CTA was carried out only when a patient was suspected of having restenosis at DUS, which may result in verification bias. Results In general, the velocity cut-off values for stenosis measurements in stented arteries were higher than those reported for unstented arteries. Previous studies often were retrospective, or the reference test (DSA or CTA was carried out only when a patient was suspected of having restenosis at DUS, which may result in verification bias. Discussion To address the deficiencies of the existing studies, we propose a prospective cohort study nested within the International Carotid Stenting Study (ICSS, an international multi-centre trial in which over 1,700 patients have been randomised between stenting and CEA. In this

  5. A clinically based prognostic index for diffuse large B-cell lymphoma with a cut-off at 70 years of age significantly improves prognostic stratification

    DEFF Research Database (Denmark)

    Gang, Anne O; Pedersen, Michael; d'Amore, Francesco

    2015-01-01

    The introduction of rituximab and generally improved health among elderly patients have increased the survival of patients with diffuse large B-cell lymphoma (DLBCL). The International Prognostic Index (IPI) from 1992 is based on pre-rituximab data from clinical trials including several lymphoma...... subtypes. We applied IPI factors to a population-based rituximab-treated cohort of 1990 patients diagnosed 2000-2010 and explored new factors and the optimal prognostic age cut-off for DLBCL. Multivariate-analyses (MVA) confirmed the prognostic value of all IPI factors except the presence of > 1 extranodal...

  6. Extracorporeal light chain elimination: high cut-off (HCO) hemodialysis parallel to chemotherapy allows for a high proportion of renal recovery in multiple myeloma patients with dialysis-dependent acute kidney injury.

    Science.gov (United States)

    Heyne, Nils; Denecke, Barbara; Guthoff, Martina; Oehrlein, Katharina; Kanz, Lothar; Häring, Hans-Ulrich; Weisel, Katja C

    2012-05-01

    Acute kidney injury (AKI) is frequent in multiple myeloma (MM) patients and strongly affects prognosis, with particularly poor outcomes in patients requiring hemodialysis. Introduction of the novel therapeutic agents to MM therapy has improved myeloma response and renal outcome. This case series reviews the efficacy of combined systemic and extracorporeal therapy to further optimize time to light chain (serum-free light chain (sFLC)) reduction and renal recovery in MM patients with dialysis-dependent AKI (n = 19). High cut-off (HCO) hemodialysis for extracorporeal sFLC removal was initiated in parallel to chemotherapy. Combined therapy resulted in early sFLC response after a median of 13 (range 4-48) days and 6 (3-22) HCO hemodialysis sessions. Time to sFLC response was shorter in patients recovering renal function. Median time to dialysis independence was 15 (4-64) days. By intent-to-treat analysis, sustained renal recovery was achieved in 73.7% (77.8% adjusted for death) of patients. In multivariate analysis, duration of AKI prior to initiation of therapy was an independent predictor of renal functional outcome. Combining HCO hemodialysis for extracorporeal sFLC elimination and effective chemotherapy is a novel treatment strategy allowing for early and sustained sFLC reduction and a high proportion of renal recovery in these patients. Timely diagnosis and onset of therapy is essential for improving renal outcome.

  7. Determination of the cut-off score of an endoscopic scoring method to predict whether elderly patients with dysphagia can eat pureed diets

    Institute of Scientific and Technical Information of China (English)

    Torao Sakamoto; Akira Horiuchi; Toshiyuki Makino; Masashi Kajiyama; Naoki Tanaka; Masamitsu Hyodo

    2016-01-01

    AIM: To identify the cut-off value for predicting the ability of elderly patients with dysphagia to swallow pureed diets using a new endoscopy scoring method. METHODS: Endoscopic swallowing evaluation of pureed diets were done in patients ≥ 65 years with dysphagia. The Hyodo-Komagane score for endoscopic swallowing evaluation is expressed as the sum(0-12) of four degrees(0-3) with four parameters:(1) salivary pooling in the vallecula and piriform sinuses;(2) the response of glottal closure reflex induced by touching the epiglottis with the endoscope;(3) the location of the bolus at the time of swallow onset assessed by "white-out" following swallowing of test jelly; and(4) pharyngeal clearance after swallowing of test jelly. We used receiver operating characteristic(ROC) curve analysis to retrospectively analyze the association between the total score and successful oral intake of pureed diets. RESULTS: One hundred and seventy-eight patients were enrolled including 113 men(63%), mean age 83 years(range, 66-98). One hundred and twenty-six patients(71%) were able to eat pureed diets during the observation period(mean ± SD, 19 ± 14 d). In ROC analysis, the cut-off value of the score for eating the pureed diets was 7(sensitivity = 0.98; specificity = 0.91).CONCLUSION: The Hyodo-Komagane endoscopic score is useful to predict the ability to eat pureed diets in elderly patients with dysphagia.

  8. Rocking at 81 and Rolling at 34: ROC Cut-Off Scores for the Negative Acts Questionnaire–Revised in Serbia

    Science.gov (United States)

    Petrović, Ivana B.; Vukelić, Milica; Čizmić, Svetlana

    2017-01-01

    Researchers are still searching for the ways to identify different categories of employees according to their exposure to negative acts and psychological experience of workplace bullying. We followed Notelaers and Einarsen’s application of the ROC analysis to determine the NAQ-R cut-off scores applying a “lower” and “higher” threshold. The main goal of this research was to develop and test different gold standards of personal and organizational relevance in determining the NAQ-R cut-off scores in a specific cultural and economic context of Serbia. Apart from combining self-labeling as a victim with self-perceived health, the objectives were to test the gold standards developed as a combination of self-labeling with life satisfaction, self-labeling with intention to leave and a complex gold standard based on self-labeling, self-perceived health, life satisfaction and intention to leave taken together. The ROC analysis on Serbian workforce data supports applying of different gold standards. For identifying employees in a preliminary stage of bullying, the most applicable was the gold standard based on self-labeling and intention to leave (score 34 and higher). The most accurate identification of victims could be based on the most complex gold standard (score 81 and higher). This research encourages further investigation of gold standards in different cultures. PMID:28119652

  9. Cut-off effect in antimicrobial activity and in membrane perturbation efficiency of the homologous series of N,N-dimethylalkylamine oxides.

    Science.gov (United States)

    Devínsky, F; Kopecka-Leitmanová, A; Sersen, F; Balgavý, P

    1990-11-01

    The antimicrobial activity of the homologous series of N,N-dimethylalkylamine oxides (DMAO) was found to be quasi parabolically dependent on alkyl chain length with a maximum at n approximately 15 and n approximately 12 for Staphylococcus aureus and Escherichia coli, respectively. The physiochemical properties of DMAOs as characterized by critical micelle concentrations, retention times of 1-alkenes generated from DMAOs by gas-liquid chromatography, Rm values in reversed phase chromatography, and bacterial lipid/aqueous phase partition coefficients were found to correlate with the alkyl chain length. The effect of DMAOs on the structure of the model membrane prepared from isolated lipids from Escherichia coli as detected by a spin probe method was maximal for the alkyl chain length n approximately 10-12 coinciding with the maximum in the antimicrobial activity observed with Escherichia coli. It is suggested that the cut-off in the DMAO antimicrobial activity is caused by the cut-off in the DMAO perturbing effect on the membrane structure.

  10. Triceps and Subscapular Skinfold Thickness Percentiles and Cut-Offs for Overweight and Obesity in a Population-Based Sample of Schoolchildren and Adolescents in Bogota, Colombia

    Science.gov (United States)

    Ramírez-Vélez, Robinson; López-Cifuentes, Mario Ferney; Correa-Bautista, Jorge Enrique; González-Ruíz, Katherine; González-Jiménez, Emilio; Córdoba-Rodríguez, Diana Paola; Vivas, Andrés; Triana-Reina, Hector Reynaldo; Schmidt-RioValle, Jacqueline

    2016-01-01

    The assessment of skinfold thickness is an objective measure of adiposity. The aims of this study were to establish Colombian smoothed centile charts and LMS L (Box–Cox transformation), M (median), and S (coefficient of variation) tables for triceps, subscapular, and triceps + subscapular skinfolds; appropriate cut-offs were selected using receiver operating characteristic (ROC) analysis based on a population-based sample of children and adolescents in Bogotá, Colombia. A cross-sectional study was conducted in 9618 children and adolescents (55.7% girls; age range of 9–17.9 years). Triceps and subscapular skinfold measurements were obtained using standardized methods. We calculated the triceps + subscapular skinfold (T + SS) sum. Smoothed percentile curves for triceps and subscapular skinfold thickness were derived using the LMS method. ROC curve analyses were used to evaluate the optimal cut-off point of skinfold thickness for overweight and obesity, based on the International Obesity Task Force definitions. Subscapular and triceps skinfolds and T + SS were significantly higher in girls than in boys (p < 0.001). The ROC analysis showed that subscapular and triceps skinfolds and T + SS have a high discriminatory power in the identification of overweight and obesity in the sample population in this study. Our results provide sex- and age-specific normative reference standards for skinfold thickness values from a population from Bogotá, Colombia. PMID:27669294

  11. Triceps and Subscapular Skinfold Thickness Percentiles and Cut-Offs for Overweight and Obesity in a Population-Based Sample of Schoolchildren and Adolescents in Bogota, Colombia

    Directory of Open Access Journals (Sweden)

    Robinson Ramírez-Vélez

    2016-09-01

    Full Text Available The assessment of skinfold thickness is an objective measure of adiposity. The aims of this study were to establish Colombian smoothed centile charts and LMS L (Box–Cox transformation, M (median, and S (coefficient of variation tables for triceps, subscapular, and triceps + subscapular skinfolds; appropriate cut-offs were selected using receiver operating characteristic (ROC analysis based on a population-based sample of children and adolescents in Bogotá, Colombia. A cross-sectional study was conducted in 9618 children and adolescents (55.7% girls; age range of 9–17.9 years. Triceps and subscapular skinfold measurements were obtained using standardized methods. We calculated the triceps + subscapular skinfold (T + SS sum. Smoothed percentile curves for triceps and subscapular skinfold thickness were derived using the LMS method. ROC curve analyses were used to evaluate the optimal cut-off point of skinfold thickness for overweight and obesity, based on the International Obesity Task Force definitions. Subscapular and triceps skinfolds and T + SS were significantly higher in girls than in boys (p < 0.001. The ROC analysis showed that subscapular and triceps skinfolds and T + SS have a high discriminatory power in the identification of overweight and obesity in the sample population in this study. Our results provide sex- and age-specific normative reference standards for skinfold thickness values from a population from Bogotá, Colombia.

  12. Power-law and Logarithmic Entropy Corrected Holographic Dark Energy Models in Brans-Dicke Cosmology with Granda-Oliveros Cut-Off

    CERN Document Server

    Pasqua, Antonio; Myrzakulov, Ratbay

    2015-01-01

    In this paper, the cosmological implications of the Power Law Entropy Corrected Holographic Dark Energy (PLECHDE) and the Logarithmic Entropy Corrected Holographic Dark Energy (LECHDE) models in the context of Brans-Dicke (BD) cosmology for both non-interacting and interacting DE and Dark Matter (DM) are studied. As the system infrared cut-off, we choose the recently proposed Granda-Oliveros cut-off, which contains a term proportional to the first time derivative of the Hubble parameter and one term proportional to $H^2$, i.e. the Hubble parameter squared. We obtain the expressions of three quantities, i.e. the Equation of State (EoS) parameter $\\omega_D$, the deceleration parameter $q$ and the evolutionary form of the energy density parameter $\\Omega'_D$ of the PLECHDE and LECHDE models in a non-flat Universe for non-interacting and interacting DE and DM as well. Moreover, we investigate the limiting cases corresponding to: a) absence of entropy corrections; b) Einstein's gravity; and c) concomitantly absenc...

  13. InGaAs Photodetectors Cut-off at 1.9μm Grown by Gas-Source Molecular Beam Epitaxy

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yong-Gang; HAO Guo-Qiang; GU Yi; ZHU Cheng; LI Ai-Zhen; LIU Tian-Dong

    2005-01-01

    @@ Using a linear graded Inx Ga1- x As as the buffer layer, positive-intrinsic-negative wavelength-extended In0.6Ga0.4As photodetectors with 50% cut-off wavelength of 1.9μm at room temperature were grown by using gas-source molecular beam epitaxy, and their performance over a wide temperature range has been extensively investigated. The detectors show typical dark current at bias voltage 50mV and the resistance-area product RO A of 7nA/765Ωcm2 and 31pA/404kΩcm2 at 290K and 210K, respectively. The thermal activation energy of the dark current in the temperature range 250-350 K is 0.488 eV.

  14. Residual magnetic field profiles and their current density profiles of coated conductors for fast and slow cut-off current operations

    Energy Technology Data Exchange (ETDEWEB)

    Sun, J.; Taillouli, M.; Hamabe, M.; Watanabe, H.; Chikumoto, N.; Yamaguchi, S. [Chubu University, Kasugai, Aichi (Japan); Shyshkin, O. [V. N. Karazin Kharkiv National University, Kharkov (Ukraine)

    2015-03-15

    Coated conductor is an important candidate for power cable applications due to its high current density. Even for DC power cable transmission, we must study the transport properties of HTS tapes after slow and fast discharge. In order to evaluate relation of the magnetic field with applied current we developed a scanning magnetic field measurements system by employing a Hall probe. This work presents the measurements of the magnetic fields above a coated conductor by varying applied current pattern. In the work, a transport current of 100 A, less than the critical current, is applied to YBCO coated conductor. We measured the residual magnetic field distributions after cut off the transport current with slow and fast operations. The results show differences of the magnetic field profiles and the corresponding current profiles by an inverse solution from the magnetic field measurement between these two operations because of the hysteresis of coated conductor excited by the transport current.

  15. Establishment of cut off values for vanillylmandelic acid and homovanillic acid in 24-hr urine accumulation during mass screening for neuroblastoma.

    Science.gov (United States)

    Nishi, M; Miyake, H; Takeda, T; Takasugi, N; Sato, Y; Hanai, J

    1987-09-01

    The establishment of cut off values in vanillylmandelic acid (VMA) and homovanillic acid (HVA) in 24-hr urine specimens for the purpose of separating true positive cases from normal infants has been discussed. The specimens were collected at the time when thorough examinations under a mass screening programme for neuroblastoma were taking place, and data from 17 infants with neuroblastoma (patients) and 50 healthy infants (controls) have been employed. The function square root VMA2 + HVA2 = 34 (micrograms/mg of creatinine) separated the two groups with no overlapping cases. This function represents the distance from the origin of the VMA-HVA co-ordinates, and is thought to be one of the most reasonable discriminant methods when considering the distribution pattern of the data for normal cases and patients.

  16. EARLY APPLICATION OF HIGH CUT-OFF HAEMODYALISIS FOR DE-NOVO MYELOMA NEPHROPATHY IS ASSOCIATED WITH LONG-TERM DIALYSIS-INDEPENDENCY AND RENAL RECOVERY

    Directory of Open Access Journals (Sweden)

    Alhossain A. Khalafallah

    2013-01-01

    Full Text Available Background Multiple myeloma (MM is a haematological malignancy associated with kidney injury resulting from cast nephropathy, which can be caused by monoclonal free light chains (FLC. It has been demonstrated that reduction of FLC can lead to a higher proportion of patients recovering renal function with a better outcome, especially if extended high cut-off haemodialysis (HCO-HD combined with chemotherapy is used. Patients and Methods In this study, four cases of MM nephropathy were treated with HCO-HD and chemotherapy at a single institution during the period from August 2009 to August 2011. All of the patients presented with acute renal failure and high serum FLC. All patients underwent a bone marrow biopsy to confirm the diagnosis of MM, according to the WHO criteria. Three patients had de-novo MM and one patient had relapsed light chain myeloma disease. All patients underwent HCO-HD concomitantly with specific myeloma therapy once the diagnosis or relapse of MM was established. Results After a median follow up of 26 months, (range, 13-36 our data showed that all patients had a significant decrease in serum FLC through HCO-HD, proving the effectiveness of HCO-HD in managing MM. De-novo MM patients restored their renal function and achieved low-level FLC early on the treatment and become dialysis-independent. One patient with relapsed myeloma remained dialysis dependant. Conclusion Our study suggests that if myeloma nephropathy associated with light-chain disease, HCO-HD should be initiated as early as possible. At the same time a specific MM treatment should be initiated to gain control of the disease and salvage the kidneys in order to achieve dialysis-independency. Further trials to confirm our results are warranted. Key Words: Multiple myeloma, renal failure, High cut-off haemodialysis, chemotherapy, outcome.

  17. The optimum cut-off value to differentiate Echinococcus granulosus sensu stricto from other species of E. granulosus sensu lato using larval rostellar hook morphometry.

    Science.gov (United States)

    Soriano, S V; Pierangeli, N B; Pianciola, L A; Mazzeo, M; Lazzarini, L E; Debiaggi, M F; Bergagna, H F J; Basualdo, J A

    2015-01-01

    Cystic echinococcosis caused by Echinococcus granulosus sensu lato is one of the most important helminth zoonoses in the world; it affects both humans and livestock. The disease is endemic in Argentina and highly endemic in the province of Neuquén. Considerable genetic and phenotypic variation has been demonstrated in E. granulosus, and ten different genotypes (G1-G10) have been identified using molecular tools. Echinococcus granulosus sensu lato may be considered a species complex, comprised of E. granulosus sensu stricto (G1-G3), E. equinus (G4), E. ortleppi (G5) and E. canadensis (G6-G10). In endemic areas, the characterization of cystic echinococcosis molecular epidemiology is important in order to apply adequate control strategies. A cut-off value for larval large hook total length to distinguish E. granulosus sensu stricto isolates from those produced by other species of the complex was defined for the first time. Overall, 1780 larval hooks of 36 isolates obtained from sheep (n= 11, G1), goats (n= 10, G6), cattle (n= 5, G6) and pigs (n= 10, G7) were analysed. Validation against molecular genotyping as gold standard was carried out using the receiver operating characteristic (ROC) curve analysis. The optimum cut-off value was defined as 26.5 μm. The proposed method showed high sensitivity (97.8%) and specificity (91.1%). Since in most endemic regions the molecular epidemiology of echinococcosis includes the coexistence of the widely distributed E. granulosus sensu stricto G1 strain and other species of the complex, this technique could be useful as a quick and economical tool for epidemiological and surveillance field studies, when fertile cysts are present.

  18. Evaluating the Possibility of Defining Cut-Off Points for ΔFA% in Order to Differentiate Four Major Types of Peri-Tumoral White Matter Tract Involvement

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    Deilami

    2015-07-01

    Full Text Available Background Diffusion tensor imaging (DTI and its different scalar values such as fractional anisotropy (FA have recently been used for evaluation of peri-tumoral white matter (WM involvement to help define safer surgical excision margins. Objectives The purpose of this study is to evaluate the possibility of defining diagnostic cut-off points for differentiating four major types of peri-tumoral WM involvement using FA. Patients and Methods DTI was performed in 12 patients with high presumption of having brain tumors, on a 1.5 T MRI scanner. DTI data was processed by MedINRIA software. Two-hundred region of interests (ROI were evaluated: 100 in the lesion zone and the rest in the normal WM in the contralateral hemisphere. FA value related to each ROI was measured, and the percentage of FA decrement (ΔFAs% was calculated. Results Of the 100 ROIs on the lesion side, 74 were related to high-grade lesions, 23 to low-grade ones, and three to “gliosis”. There were 54 “infiltrated”, 22 “displaced”, 15 “disrupted”, and 9 “edematous” tracts. The major type of fiber involvement, both in low-grade and high-grade tumors was “infiltrated, whereas “edematous” fibers comprised the minority. ΔFA% was more than -35 for “displaced” and “edematous” fibers, and less than -35 for the majority of “disrupted” ones, but “infiltrated” fibers had scattered distribution. Mean ΔFA% was the least for “disrupted”, followed by “infiltrated”, “edematous” and “displaced” parts. Conclusion Introducing definite diagnostic cut-points was not possible, due to overlap. Based on the fact that “disruption” is the most aggressive process, a sensitivity analysis was carried out for “disrupted” fibers for several presumptive cut-off points.

  19. Lipid ratios and appropriate cut off values for prediction of diabetes: a cohort of Iranian men and women

    Directory of Open Access Journals (Sweden)

    Hadaegh Farzad

    2010-08-01

    Full Text Available Abstract Background Dyslipidemia is a risk factor for incident type 2 diabetes; however, no study has specifically assessed the lipid ratios (i.e. total cholesterol (TC/high density lipoprotein cholesterol (HDL-C and triglyceride (TG/HDL-C as predictors of diabetes. We aimed to compare the independent association between the different lipid measures with incident diabetes over a median follow up of 6.4 years in Iranian men and women. Method The study population consisted of 5201 non diabetic (men = 2173, women = 3028 subjects, aged ≥20 years. The risk factor adjusted odds ratios (ORs for diabetes were calculated for every 1 standard deviation (SD change in TC, log-transformed TG, HDL-C, non-HDL-C, TC/HDL-C and log-transformed TG/HDL-C using multivariate logistic regression analysis. Receiver operator characteristic (ROC curve analysis was used to define the points of the maximum sum of sensitivity and specificity (MAXss of each lipid measure as a predictor of diabetes. Result We found 366 (146 men and 220 women new diabetes cases during follow-up. The risk-factor-adjusted ORs for a 1 SD increase in TG, TC/HDL-C and TG/HDL-C were 1.23, 1.27 and 1.25 in men; the corresponding risks in females were 1.36, 1.14, 1.39 respectively (all p Conclusion TC/HDL-C and TG/HDL-C showed similar performance for diabetes prediction in men population however; among women TG/HDL-C highlighted higher risk than did TC/HDL-C, although there was no difference in discriminatory power. Importantly, HDL-C had a protective effect for incident diabetes only among women.

  20. The Optimal Ethnic-Specific Waist-Circumference Cut-Off Points of Metabolic Syndrome among Low-Income Rural Uyghur Adults in Far Western China and Implications in Preventive Public Health.

    Science.gov (United States)

    He, Jia; Ma, Rulin; Liu, Jiaming; Zhang, Mei; Ding, Yusong; Guo, Heng; Mu, Lati; Zhang, Jingyu; Wei, Bin; Yan, Yizhong; Ma, Jiaolong; Pang, Hongrui; Li, Shugang; Guo, Shuxia

    2017-02-08

    Background: Metabolic syndrome is pandemic; however, the cut-off values for waist circumference (WC) vary widely depending on the ethnic groups studied and the criteria applied for WC measurement. Previous studies for defining optimal WC cut-off points included high-income and urban settings, and did not cover low-income, rural settings, especially for ethnic minorities. This study aimed at defining optimal ethnic-specific WC cut-off points in a low-income, rural population comprising the largest inhabitant minority group residing in far Western China. Methods: Questionnaire-based surveys, physical examinations, and blood testing of 3542 individuals were conducted in 2010, using a stratified cluster random sampling method in rural Uyghur residents (≥18 years old) from 12 villages in Xinjiang, China, approximately 4407 km away from the capital city, Beijing. Metabolic syndrome was defined according to the International Diabetes Federation (IDF) criteria. Optimal, ethnic-specific WC cut-off values for diagnosing metabolic syndrome were determined using receiver operator characteristic (ROC) curve analysis. Results: As WC increased, there was a significant, increasing trend of detection and risk in rural Uyghur adults, regardless of the presence of ≥1 or ≥2 components of metabolic syndrome by IDF criteria. The optimal ethnic-specific WC cut-off point to predict the presence of metabolic syndrome was 85 cm for men and 82 cm for women. With these cut-off points, the prevalence rates of metabolic syndrome among men, women, and overall population in Uyghur adults were 19.5%, 23.0%, and 21.3%, respectively. Conclusions: We report a high prevalence of metabolic syndrome, especially in women, among rural Uyghurs in Western China. A WC cut-off of 85 cm in men and 82 cm in women was the best predictor of metabolic syndrome in this population. Because of the cost-effectiveness in measuring WC, we recommend that these WC cut-off points be integrated into local preventive

  1. Cut-Off Points for Mild, Moderate, and Severe Pain on the Numeric Rating Scale for Pain in Patients with Chronic Musculoskeletal Pain: Variability and Influence of Sex and Catastrophizing

    Science.gov (United States)

    Boonstra, Anne M.; Stewart, Roy E.; Köke, Albère J. A.; Oosterwijk, René F. A.; Swaan, Jeannette L.; Schreurs, Karlein M. G.; Schiphorst Preuper, Henrica R.

    2016-01-01

    Objectives: The 0–10 Numeric Rating Scale (NRS) is often used in pain management. The aims of our study were to determine the cut-off points for mild, moderate, and severe pain in terms of pain-related interference with functioning in patients with chronic musculoskeletal pain, to measure the variability of the optimal cut-off points, and to determine the influence of patients’ catastrophizing and their sex on these cut-off points. Methods: 2854 patients were included. Pain was assessed by the NRS, functioning by the Pain Disability Index (PDI) and catastrophizing by the Pain Catastrophizing Scale (PCS). Cut-off point schemes were tested using ANOVAs with and without using the PSC scores or sex as co-variates and with the interaction between CP scheme and PCS score and sex, respectively. The variability of the optimal cut-off point schemes was quantified using bootstrapping procedure. Results and conclusion: The study showed that NRS scores ≤ 5 correspond to mild, scores of 6–7 to moderate and scores ≥8 to severe pain in terms of pain-related interference with functioning. Bootstrapping analysis identified this optimal NRS cut-off point scheme in 90% of the bootstrapping samples. The interpretation of the NRS is independent of sex, but seems to depend on catastrophizing. In patients with high catastrophizing tendency, the optimal cut-off point scheme equals that for the total study sample, but in patients with a low catastrophizing tendency, NRS scores ≤ 3 correspond to mild, scores of 4–6 to moderate and scores ≥7 to severe pain in terms of interference with functioning. In these optimal cut-off schemes, NRS scores of 4 and 5 correspond to moderate interference with functioning for patients with low catastrophizing tendency and to mild interference for patients with high catastrophizing tendency. Theoretically one would therefore expect that among the patients with NRS scores 4 and 5 there would be a higher average PDI score for those with low

  2. The Optimal Ethnic-Specific Waist-Circumference Cut-Off Points of Metabolic Syndrome among Low-Income Rural Uyghur Adults in Far Western China and Implications in Preventive Public Health

    Directory of Open Access Journals (Sweden)

    Jia He

    2017-02-01

    Full Text Available Background: Metabolic syndrome is pandemic; however, the cut-off values for waist circumference (WC vary widely depending on the ethnic groups studied and the criteria applied for WC measurement. Previous studies for defining optimal WC cut-off points included high-income and urban settings, and did not cover low-income, rural settings, especially for ethnic minorities. This study aimed at defining optimal ethnic-specific WC cut-off points in a low-income, rural population comprising the largest inhabitant minority group residing in far Western China. Methods: Questionnaire-based surveys, physical examinations, and blood testing of 3542 individuals were conducted in 2010, using a stratified cluster random sampling method in rural Uyghur residents (≥18 years old from 12 villages in Xinjiang, China, approximately 4407 km away from the capital city, Beijing. Metabolic syndrome was defined according to the International Diabetes Federation (IDF criteria. Optimal, ethnic-specific WC cut-off values for diagnosing metabolic syndrome were determined using receiver operator characteristic (ROC curve analysis. Results: As WC increased, there was a significant, increasing trend of detection and risk in rural Uyghur adults, regardless of the presence of ≥1 or ≥2 components of metabolic syndrome by IDF criteria. The optimal ethnic-specific WC cut-off point to predict the presence of metabolic syndrome was 85 cm for men and 82 cm for women. With these cut-off points, the prevalence rates of metabolic syndrome among men, women, and overall population in Uyghur adults were 19.5%, 23.0%, and 21.3%, respectively. Conclusions: We report a high prevalence of metabolic syndrome, especially in women, among rural Uyghurs in Western China. A WC cut-off of 85 cm in men and 82 cm in women was the best predictor of metabolic syndrome in this population. Because of the cost-effectiveness in measuring WC, we recommend that these WC cut-off points be integrated into

  3. Predictive values of D-dimer assay, GRACE scores and TIMI scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction

    Science.gov (United States)

    Satilmisoglu, Muhammet Hulusi; Ozyilmaz, Sinem Ozbay; Gul, Mehmet; Ak Yildirim, Hayriye; Kayapinar, Osman; Gokturk, Kadir; Aksu, Huseyin; Erkanli, Korhan; Eksik, Abdurrahman

    2017-01-01

    Purpose To determine the predictive values of D-dimer assay, Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) risk scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Patients and methods A total of 234 patients (mean age: 57.2±11.7 years, 75.2% were males) hospitalized with NSTEMI were included. Data on D-dimer assay, GRACE and TIMI risk scores were recorded. Logistic regression analysis was conducted to determine the risk factors predicting increased mortality. Results Median D-dimer levels were 349.5 (48.0–7,210.0) ng/mL, the average TIMI score was 3.2±1.2 and the GRACE score was 90.4±27.6 with high GRACE scores (>118) in 17.5% of patients. The GRACE score was correlated positively with both the D-dimer assay (r=0.215, P=0.01) and TIMI scores (r=0.504, P=0.000). Multivariate logistic regression analysis revealed that higher creatinine levels (odds ratio =18.465, 95% confidence interval: 1.059–322.084, P=0.046) constituted the only significant predictor of increased mortality risk with no predictive values for age, D-dimer assay, ejection fraction, glucose, hemoglobin A1c, sodium, albumin or total cholesterol levels for mortality. Conclusion Serum creatinine levels constituted the sole independent determinant of mortality risk, with no significant values for D-dimer assay, GRACE or TIMI scores for predicting the risk of mortality in NSTEMI patients.

  4. Safe Exclusion of Deep Vein Thrombosis by a Rapid Sensitive ELISA D-dimer and Compression Ultrasonography in 1330 Outpatients With Suspected DVT.

    Science.gov (United States)

    Michiels, Jan Jacques; Maasland, Hanny; Moossdorff, Wim; Lao, Mildred; Gadiseur, Alain; Schroyens, Wilfried

    2016-09-01

    Of 1330 outpatients with suspected deep vein thrombosis (DVT), a normal enzyme-linked immunosorbent assay (ELISA) d-dimer (VIDAS) of DVT, the CUS was positive for the alternative diagnoses (AD): Bakers cyst, muscle hematoma, or old DVT in 62 (5.8%); superficial vein thrombosis without DVT in 78 (7.4%), and leg edema or varices in 17%. A second CUS in 641 patients was positive in 26 (4.0%), indicating an NPV of 96% after a first negative CUS. The NPV of the combination of a negative first CUS and a ELISA d-dimer test DVT and AD for subsequent evaluation in a large prospective study.

  5. Comparison of three kinds of methods of detection of d-dimer%3种检测D-二聚体方法的比较

    Institute of Scientific and Technical Information of China (English)

    裴依菲; 尹娟

    2015-01-01

    目的:干式免疫散射色谱法,免疫比浊法,VIDAS D-二聚体定量分析3种方法测定D-二聚体进行比较。方法:用干式免疫散射色谱法,免疫比浊法,VIDAS D-二聚体定量分析3种方法对待测样本分别进行测定。结果:3组特异性较一致,但VIDAS D-二聚体定量分析方法准确度和线性范围均优于另外2种方法,且不受溶血、脂血、胆血及类风湿因子( RF)的影响。结论:VIDAS D-二聚体定量分析方法准确度高和灵敏度高,线性范围广,且不受溶血、脂血、胆血及类风湿因子( RF)的影响,WHO建议D-二聚体国际检测标准方法为ELISA( VIDAS D-Dimer),是检测D-二聚体的首选方法。%Objective To discuss dry scatter chromatography, immunoturbidimetric method, VIDAS d-dimer in quantitative analysis of three kinds of methods for the determination of d-dimer were compared.Methods:Using dry scatter chromatography, immunoturbidimet-ric method, VIDAS d-dimer analysis three ways to measure the samples were measured.Results:Three groups of specificity was gener-ally agreed, VIDAS d-dimer method accuracy and linearity were better than the other two methods, and was not affected by hemolysis, blood lipid, blood and bile of rheumatoid factor ( RF) effects.Conclusion:VIDAS d-dimer analysis method of high accuracy and high sensitivity, wide range of linear and not affected by hemolysis, blood lipid, blood and bile of rheumatoid factor ( RF) of, WHO recom-mended international standard method for detecting d-dimer as ELISA ( VIDAS D-Dimer) , which should be the preferred method for the detection of d-dimer.

  6. The relationship between level of plasma D-dimer and survival time in metastatic gastric cancer patients%血浆D-二聚体水平与转移性胃癌患者生存期的关系

    Institute of Scientific and Technical Information of China (English)

    Xiaodong Jiao; Jianxin Qian; Guanzhen Yu; Rui Li; Zhan Wang; Jin Wang; Xiaoqiang Gu; Jiejun Wang

    2011-01-01

    Objective: The principal purpose of this study was to determine the relationship between level of plasma D-dimer and survival time in metastatic gastric cancer patients. Methods: We retrospectively collected the data of plasma D-dimer in metastatic gastric cancer patients admitted in our Department (Department of Oncology, The Affiliated Changzheng Hospital, The Second Military Medical University, Shanghai, China) from October 2006 to October 2008 and analyzed the relationship between level of plasma D-dimer and survival time along with other clinicopathologic parameters. Results: A total of 82 patients were studied in our research, 52 were males and 30 females, and the mean age was 57 years. The 48 cases had a normal plasma D-dimer level (< 300 μg/L) and 34 had a high plasma D-dimer level (≥ 300 μg/L). In the normal and high plasma D-dimer level groups, the mean survival times were 10.9 (95% CI: 9.8-12.2) months and 6.8 (95% CI: 4.4-7.6) months respectively, and the difference was statistically significant. Conclusion: Metastatic gastric cancer patients with high plasma D-dimer level had significantly shorter survival time than those with normal plasma D-dimer level. Level of plasma D-dimer can be referred as a potential predictor in metastatic gastric cancer patients.

  7. Alzheimer's disease dementia as the diagnosis best supported by the cerebrospinal fluid biomarkers: difference in cut-off levels from thai experience.

    Science.gov (United States)

    Senanarong, V; Siwasariyanon, N; Washirutmangkur, L; Poungvarin, N; Ratanabunakit, C; Aoonkaew, N; Udomphanthurak, S

    2012-01-01

    Objectives. To determine how beta-amyloid 1-42 (Aβ 1-42), total tau (tTau), and phosphorylated tau (pTau) levels in CSF behave in a cohort of Thai patients from the Memory Clinic in Bangkok, Thailand. Methods. During 2009-2011, twenty eight subjects from the memory clinic at Siriraj Hospital had CSF analysis for AD biomarkers. Aβ 1-42, tTau, and pTau (at amino acid 181) were measured in CSF by ELISA technique. Results. Mean of Thai mental state examination (TMSE) of 28 Thai cohort was 16.48 (6.63). Fourteen had AD, ten had non-AD dementia, and four non-cases were those with subjective memory complaint (SMC) without dementia. Mean CSF Aβ 1-42, tTau, ptau (181), and pTau/Aβ 1-42 in the AD group were 241.36 (60.14) pg/mL, 222.79 (212.24) pg/mL, 40.79 (27.84) pg/mL, and 0.18 (0.12) accordingly. Mean CSF Aβ 1-42, tTau, pTau (181), and pTau/Aβ 1-42 in the non-AD dementia group were 430.40 (125.18) pg/mL, 349.30 (692.16) pg/mL, 36.80 (14.90) pg/mL, and 0.09 (0.04) accordingly. Mean CSF Aβ 1-42, tTau, pTau (181), and pTau/Aβ 1-42 in the non-cases with SMC without dementia were 499.75 (93.44) pg/mL, 137.25 (62.74) pg/mL, 31.75 (17.48) pg/mL, and 0.06 (0.02). There is significant difference (P < 0.05) among the 3 groups in CSF Aβ 1-42 and pTau/Aβ 1-42. We propose mean + 1.5 SD of CSF Aβ 1-42 in AD group (331.57 pg/mL) to be the cut-off point in Thai subjects. Conclusion. There are significant different in CSF Aβ 1-42 and CSF p-tau/Aβ 1-42 among those with AD, non-AD dementia and non cases with SMC without dementia in Thai cohort. Cut-off point of CSF Aβ 1-42 of 331.57 pg/mL is suggested in Thai study.

  8. Vocoder Excitation Model Based on Voicing Cut-Off Frequency%基于语音截止频率的声码器激励模型

    Institute of Scientific and Technical Information of China (English)

    徐静云; 赵晓群; 李荣芸; 王峤

    2015-01-01

    在低速率声码器中,对激励信号的描述直接影响重建语音的质量。为了改善音质,提出一种基于语音截止频率的声码器激励模型。该模型编码时通过语音截止频率将激励谱分成谐波和噪声2个子带,谐波子带的激励谱幅度引入离散余弦变换变维模型进行描述,语音截止频率进行4 bit 非线性量化。解码时将恢复出的谐波子带激励谱幅度进行傅里叶反变换,噪声子带则由白噪声进行以语音截止频率为阻带截止频率的高通滤波,最后由谐波子带和噪声子带叠加出激励。实验结果表明,该模型提高了全带激励谱幅度和谐波噪声成分的描述精度,可使重建语音的音质得以明显改善,主客观指标更优,对男声更为突出。%A vocoder excitation model based on voicing cut-off frequency(VCO) was presented. In enco-ding part, the excitation spectrum was divided into two distinct spectral bands by VCO: harmonic sub-band and noise sub-band, the model of variable dimension through discrete cosine transform was used to express the excitation spectral parameter of harmonic sub-band, and VCO was quantized through 4bits nonlinear scalar quantization. In decoding part, the recovered excitation spectral parameter of harmonic sub-band was inversely Fourier transformed, the noise sub-band was obtained by the white noise pass through a high pass filter which used the VCO as the stop-band cut-off frequency, harmonic sub-band and noise sub-band were superimposed to get the excitation. The model greatly improves the description preci-sion of the entire spectral envelope and harmonic plus noise components. With better subjective and ob-jective indicators, especially for male’s speech, the reconstructed speech shows more natural.

  9. Removal of methadone by extended dialysis using a high cut-off dialyzer: implications for the treatment of overdose and for pain management in patients undergoing light chain removal.

    Science.gov (United States)

    Arelin, Viktor; Schmidt, Julius J; Kayser, Nathalie; Kühn-Velten, W Nikolaus; Suhling, Hendrik; Eden, Gabriele; Kielstein, Jan T

    2016-06-01

    The synthetic opioid methadone hydrochloride has a low molecular weight of 346 D, a high volume of distribution (4 - 7 L/kg), and is lipophilic. It is used as an analgesic and for the maintenance treatment of opiate dependence. In drug addicts, methadone is frequently involved in mixed intoxications that can lead to death. Here we present the case of a drug addict in whom a high cut-off dialysis membrane together with extended dialysis was used in the setting of suspected overdose and acute kidney injury. Although the observed dialyzer plasma clearance (31.5 mL/min) and reduction ratio (38%) were higher than previously reported for standard hemodialysis, the total amount of methadone in the spent dialysate after 1 extended dialysis session was quite low. Hence, even extended dialysis with a high cut-off membrane does not seem to offer a clinically relevant benefit in the setting of overdose for enhanced methadone removal. On the other hand, in patients undergoing high cut-off dialysis for the removal of light chains, methadone could still be used as an analgesic without an additional dose after high cut-off hemodialysis.

  10. Establishment the cut-off value of congenital hypothyroidism on newborn in Guangzhou city%广州市新生儿先天性促甲状腺素筛查切值的建立和探讨

    Institute of Scientific and Technical Information of China (English)

    蒋翔; 江剑辉; 李蓓; 吴伽; 陈倩瑜; 曹伟锋; 贾雪芳; 李慧

    2013-01-01

    【Objective】 To get the distribution of thyroid stimulating hormone (TSH) and cut-off value in Guangzhou city. 【Method】 The results of 209 534 newborns were analysed from September 2011 to August 2012,which was described by percentiles and ROC curve,and determined the reasonable cut-off value combined with the actual screening results. 【Results】 The distribution of newborn screen was deflection,P99 was 9. 63 mU/L,the optimal cut-off value was 14 mU/L by ROC curve,the low cut-off value of our lab was 9 mU/L and the high cut-off value was 25 mU/L. 【Conclusion】 It is necessary to establish the reasonable cut-off value before earring out the neonatal screening. The determination of low and high cut-off value and establishment of recall-back methods are effective mode for neonatal screening.%[目的]探讨广州地区新生儿先天性促甲状腺素的水平分布并建立本地区的筛查实验切值. [方法]对广州市2011年9月-2012年8月间209 534例新生儿先天性甲状腺功能低下筛查的结果进行统计,使用百分位数法及ROC曲线计算促甲状腺素(thyroid stimulating hormone,TSH)参考切值,并结合实际筛查工作确定合理的切值. [结果]新生儿疾病筛查TSH水平呈偏态分布,TSH水平P99为9.63 mU/L,ROC曲线计算的最佳TSH值为14 mU/L,最终确定的TSH低切值为9 mU/L,高切值为25 mU/L. [结论]在开展筛查工作之前必须根据本地区的实际情况确立适宜的切值,确立高低两个切值并建立不同的召回方式对甲低筛查工作是合理有效的模式.

  11. Analysis on Cutting-off of Non-fire-fighting Power Supply of Metro Stations%地铁车站非消防电源的切除分析

    Institute of Scientific and Technical Information of China (English)

    郭莉

    2014-01-01

    现行国家相关设计规范对火灾时非消防电源的切除提出了明确的规定,但对火灾时切除非消防电源的目的、方式(手动方式或自动方式)及位置并未形成一致的要求。针对这些问题,进行较为深入的分析。明晰了火灾时切除非消防电源的主要原则和目标,即:避免造成人员恐慌和二次事故;避免火灾的进一步扩大;保证火灾扑救人员的安全,避免造成触电事故;在保证消防救灾的前提下,尽量减小断电范围。最后,结合地铁车站用电负荷及运营管理的特点,提出车站设备区、公共区发生火灾时切除非消防电源的原则、方式及位置。%In the current national design codes and standards,there are definite provisions for the cutting-off of the non-fire-fighting power supply,however,there are no specific provisions on the purposes,manners (manual cutting-off manner or automatic cutting-off manner)and positions of the cutting-off of the non-fire-fighting power supply.In this article,analysis is made on the purposes,manners (manual cutting-off manner or automatic cutting-off manner)and positions of the cutting-off of the non-fire-fighting power supply.The main principles and purposes of the cutting-off of the non-fire-fighting power supply in case of fire are defined,i.e.,trying to avoid passenger chaos and secondary incident,trying to avoid further spread of the fire,trying to ensure the safety of the firefighters and trying to minimize the power cutting-off scope.Finally,the principles,manners and positions of the cutting-off of the non-fire-fighting power supply in case of fire occurring in the equipment area and public area of Metro stations are proposed on basis of the features of the power load and operation management of Metro stations.

  12. Evaluation of epidemiological cut-off values indicates that biocide resistant subpopulations are uncommon in natural isolates of clinically-relevant microorganisms.

    Directory of Open Access Journals (Sweden)

    Ian Morrissey

    Full Text Available To date there are no clear criteria to determine whether a microbe is susceptible to biocides or not. As a starting point for distinguishing between wild-type and resistant organisms, we set out to determine the minimal inhibitory concentration (MIC and minimal bactericidal concentration (MBC distributions for four common biocides; triclosan, benzalkonium chloride, chlorhexidine and sodium hypochlorite for 3319 clinical isolates, with a particular focus on Staphylococcus aureus (N = 1635 and Salmonella spp. (N = 901 but also including Escherichia coli (N = 368, Candida albicans (N = 200, Klebsiella pneumoniae (N = 60, Enterobacter spp. (N = 54, Enterococcus faecium (N = 53, and Enterococcus faecalis (N = 56. From these data epidemiological cut-off values (ECOFFs are proposed. As would be expected, MBCs were higher than MICs for all biocides. In most cases both values followed a normal distribution. Bimodal distributions, indicating the existence of biocide resistant subpopulations were observed for Enterobacter chlorhexidine susceptibility (both MICs and MBCs and the susceptibility to triclosan of Enterobacter (MBC, E. coli (MBC and MIC and S. aureus (MBC and MIC. There is a concern on the potential selection of antibiotic resistance by biocides. Our results indicate however that resistance to biocides and, hence any potential association with antibiotic resistance, is uncommon in natural populations of clinically relevant microorganisms.

  13. Patient Acceptable Symptom State in Self-Report Questionnaires and Composite Clinical Disease Index for Assessing Rheumatoid Arthritis Activity: Identification of Cut-Off Points for Routine Care

    Directory of Open Access Journals (Sweden)

    Fausto Salaffi

    2015-01-01

    Full Text Available Objective. To provide information on the value of Patient Acceptable Symptom State (PASS in rheumatoid arthritis (RA by the identification of PASS thresholds for patient-reported outcomes (PROs composite scores. Methods. The characteristics of RA patients with affirmative and negative assignment to PASS were compared. Contributors to physician response were estimated by logistic regression models and PASS thresholds by the 75th percentile and receiver-operating characteristic (ROC curve methods. Results. 303 RA patients completed the study. All PROs were different between the PASS (+ and PASS (− groups (p<0.0001. The thresholds with the 75th percentile approach were 2.0 for the RA Impact of Disease (RAID score, 2.5 for the PRO-CLinical ARthritis Activity (PRO-CLARA index, and 1.0 for the Recent-Onset Arthritis Disability (ROAD questionnaire. The cut-off values for Clinical Disease Activity Index (CDAI were in the moderate range of disease activity. Assessing the size of the logistic regression coefficients, the strongest predictors of PASS were the disease activity (p=0.0007 and functional state level (0.006. Conclusion. PASS thresholds were relatively high and many patients in PASS had moderate disease activity states according to CDAI. Factors such as disease activity and physical function may influence a negative PASS.

  14. Cut-off of Non-fire Power Supply in Civil Buiding%民用建筑非消防电源的切除

    Institute of Scientific and Technical Information of China (English)

    樊海东

    2011-01-01

    Fire fighting system is related to personal property and is importance in design and examination.The rules about cutting off non-fine power supply under firing had be early set.But following the improvement of people's life,the classification of non-fire%消防系统关系到人身及财产安全,一直是设计及审查的重点。关于火灾状态下非消防电源的切除要求各规范中早有规定,但随着生活水平的提高,非消防电源的分类日趋复杂。就火灾状态下如何合理切断非消防电源进行了论述,希望电气设计师在设计过程中加深对众多规范的理解,使设计成果更加合理。

  15. Determining cut-off values for neck circumference as a measure of the metabolic syndrome amongst a South African cohort: the SABPA study.

    Science.gov (United States)

    Hoebel, S; Malan, L; de Ridder, J H

    2012-10-01

    The aim was to determine receiver operating characteristic (ROC) neck circumference (NC) cut offs best associated with the metabolic syndrome (MetS) in a South African cohort. We included 409 urban Africans and Caucasians and stratified them into gender and age groups (25-45 years; 45-65 years). Measurements included anthropometric, fasting overnight urine and biological markers for the MetS (systolic and diastolic blood pressure, glucose, triglycerides, and high density lipoprotein). ROC analysis determined pathological (NC) cut-points of 39 and 35 cm for young and older African men; 32 and 35 cm for young and old African women; 40 and 41 cm for Caucasian men; 34 and 33 cm for Caucasian women. Pathological NC cut-points significantly predicted MetS in all ethnic-gender-age groups except in African women (ORs 2.3-5.4; 95% CI 1.36-16.5). Multiple regression analyses revealed that MetS prevalence and ROC cut-points were not associated with renal impairment in any groups. ROC NC cut-points demonstrated that NC may be used as an additional anthropometric marker to predict the MetS in a South African cohort but not in African women.

  16. UV Filtering of Dye-Sensitized Solar Cells: The Effects of Varying the UV Cut-Off upon Cell Performance and Incident Photon-to-Electron Conversion Efficiency

    Directory of Open Access Journals (Sweden)

    Matthew Carnie

    2012-01-01

    Full Text Available With current technology, UV filters are essential to ensure long-term dye-sensitized solar cell (DSC stability. Blocking photons, however, will have an obvious effect on device performance and upon its incident photon-to-current conversion efficiency (IPCE. Filters have been applied to DSC devices with a range of cut-off wavelengths in order to assess how different levels of filtering affect the performance and IPCE of devices made with three different dyes, namely N719, Z907, and N749. It is shown that dyes that extend their IPCE further into the NIR region suffer lesser relative efficiency losses due to UV filtering than dyes with narrower action spectra. Furthermore, the results are encouraging to those working towards the industrialisation of DSC technology. From the results presented it can be estimated that filtering at a level intended to prevent direct band gap excitation of the TiO2 semiconductor should cause a relative drop in cell efficiency of no more than 10% in forward illuminated devices and no more than 2% in reverse illuminated devices.

  17. PREVALENCE OF WASTED, OVERWEIGHT AND OBESE CHILDREN BASED ON WORLD HEALTH ORGANISATION CUT-OFFS FOR BODY MASS INDEX, IN A URBAN SLUM

    Directory of Open Access Journals (Sweden)

    Sukanya Badami

    2014-11-01

    Full Text Available INTRODUCTION: BMI is a good indicator of levels of body fat, and it is known that having a BMI that is either too low or too high is associated with an increased risk of ill health during childhood as well as later in life. BMI is relatively quick and easy to calculate and as a result, is used for population surveys and by health professionals when assessing individual patients. OBJECTIVES: To assess the prevalence of wasted, overweight and obese children in an urban slum using WHO child growth standards BMI cut offs. MATERIALS AND METHODS: Study included 150 urban slum children of whom 77 were boys and 73 were girls. Anthropometric data in the form of height in cms and weight in kgs were collected by standard methods as reported by D. B. Jelliffe. BMI was calculated. Analysis of data was done according to WHO child growth standards. RESULTS: The prevalence of wasting was 25.97% in boys and 24.65% in girls. Among boys 1.29% were at risk of overweight, 2.59% were overweight, 2.59% were obese. Among girls 5.47% were at risk of overweight and 2.73% were obese. CONCLUSION: It can concluded from the study that undernutrition remains the main problem than overnutrition. However, the rapid changes in the dietary patterns and life styles occurring in many developing countries warrant close monitoring of overweight prevalence in children so that preventive measures can be taken in timely manner.

  18. Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients

    DEFF Research Database (Denmark)

    Stender, Mogens; Frøkjaer, Jens Brøndum; Hagedorn Nielsen, Tina Sandie

    2008-01-01

    The preoperative prevalence of deep venous thrombosis (DVT) in patients with colorectal cancer may be as high as 8%. In order to minimize the risk of pulmonary embolism, it is important to rule out preoperative DVT. A large study has confirmed that a negative D-dimer test in combination with a low...

  19. Interleukin 6 Is a Stronger Predictor of Clinical Events Than High-Sensitivity C-Reactive Protein or D-Dimer During HIV Infection

    DEFF Research Database (Denmark)

    Borges, Álvaro H; O'Connor, Jemma L; Phillips, Andrew N;

    2016-01-01

    BACKGROUND:  Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hsCRP), and D-dimer levels are linked to adverse outcomes in human immunodeficiency virus (HIV) infection, but the strength of their associations with different clinical end points warrants investigation. METHODS:  Participants...

  20. Clinical study on the influence of phloroglucinol on plasma angiotensin II and D-Dimer index in patients with severe pregnancy-induced hypertension.

    Science.gov (United States)

    Ai, Liang; Lan, Xinzhi; Wang, Limin; Xu, Yanjie; Zhang, Bin

    2016-07-01

    To observe the effect of phloroglucinol on plasma angiotensin II and D-dimer index when it was applied to patients with severe pregnancy-induced hypertension. 212 cases of severe pregnancy-induced hypertension patients diagnosed clinically were selected to be randomly divided into the research group and the control group. The research groups were given phloroglucinol, while the control groups were given magnesium sulfate. The plasma angiotensin II and D-dimer index in patients were detected before treatment and after 7 days respectively with statistical analysis of results. The diffidence after treatment was statistically significant (P0.05). It showed that the research group could reduce the plasma D-dimer and angiotensin II index in severe pregnancy-induced hypertension patients, and its effect was significantly better than the control group according to the plasma D-dimer and angiotensin II index changes in patients, it indicated that it was effective of phloroglucinol treatment for patients with pregnancy-induced hypertension disease and superior to the western medicine conventional treatment, worth clinical promotion.

  1. The predictive values of D-dimer for the early prognosis of the acute myocardial infarction(AMI):a review of 3134 AMI patients

    Institute of Scientific and Technical Information of China (English)

    杨军

    2013-01-01

    Objective To investigate whether D-dimer could be an early warning signal for patients with acute myocardial infarction(AMI),then may be helpful in risk accessment in emergency department. Methods Three thousand one hundred and thirty-four emergency AMI cases admitted to

  2. Selective D-dimer thresholds in the diagnostic management for symptomatic pulmonary embolism does not lead to acceptable 3 months venous thromboembolism recurrence rates

    NARCIS (Netherlands)

    Van Der Hulle, T.; Den Exter, P.L.; Klok, F.A.; Erkens, P.G.M.; Van Es, J.; Kamphuisen, P.W.; Huisman, M.V.; Mos, I.C.M.; Ten Cate, H.

    2013-01-01

    Background: With current diagnostic algorithms for pulmonary embolism (PE) CT-scan imaging is still frequently necessary. For deep vein thrombosis it was very recently shown (Linkins et al. Ann Intern Med 2013; 158:93-100) that doubling the D-dimer threshold in patients with low clinical probability

  3. D-二聚体在急性心肌梗死中的应用%Application of D - dimer in Acute Myocardial Infarction

    Institute of Scientific and Technical Information of China (English)

    廖佩娟; 谢睿彬

    2014-01-01

    Objective To explore tje application of value of tje D-dimer in patients witj acute myocardial infarction,to guide tje D- dimer in tje diagnosis and differential diagnosis of acute myocardial infarction disease. Method Tje results in 203 patients witj acute myocardial infarction D-dimer were analyzed retrospectively from January 2010 to June 2013. Results 97. 0% of patients witj acute myo-cardial infarction D-dimer values <0. 5 ng/ml,wjile only 3. 0% of patients witj acute myocardial infarction values of D-dimer acuity≥0. 5 ng/ml. Conclusion D-dimer value in 97% of patients witj acute myocardial infarction< 0. 5 ng/ml level,it is advantageous to tje diagnosis of acute myocardial infarction patients witj cjest pain and D-dimer value jigjer diseases sucj as pulmonary embolism,and tje identification of aortic dissection.%目的:探讨D-二聚体在急性心肌梗死患者中的应用价值,指导D-二聚体在急性心肌梗死疾病中的诊断和鉴别诊断。方法:回顾性分析2010年~2013年6月203例冠心病,急性心肌梗死患者D-二聚体的结果。结果:97.0%的急性心肌梗死患者D-二聚体值<0.5 ng/ml,仅有3.0%的急性心肌梗死患者D-二聚体值≥0.5 ng/ml。结论:D-二聚体值在97%的急性心肌梗死患者中<0.5 ng/ml水平,有利于在胸痛患者诊断中急性心肌梗死与D-二聚体值较高的疾病如肺栓塞及主动脉夹层的鉴别。

  4. Comparing the Cervista HPV HR test and Hybrid Capture 2 assay in a Dutch screening population: improved specificity of the Cervista HPV HR test by changing the cut-off.

    Directory of Open Access Journals (Sweden)

    Aniek Boers

    Full Text Available The diagnostic performance of the widely-used Cervista HPV HR test was compared to the Hybrid Capture 2 (HC2 test in a Dutch population-based cervical cancer screening program. In 900 scrapings of women with normal cytomorphology, specificity was 90% (95%CI: 87.84-91.87 for the Cervista HPV HR test and 96% (95%CI: 94.76-97.37 for the HC2 test with 93% agreement between both tests (κ = 0.5, p<0.001. The sensitivity for CIN2+ using 65 scrapings of women with histological-confirmed CIN2+ was 91% (95%CI: 80.97-96.51 for the Cervista HPV HR test and 92% (95%CI: 82.94-97.43 for the HC2 test with 95% agreement between both tests (κ = 0.7, p<0.001. Fifty-seven of 60 HC2 negative/Cervista positive cases tested HPV-negative with PCR-based HPV assays; of these cases 56% were defined as Cervista triple-positive with FOZ values in all 3 mixes higher than the second cut-off of 1.93 (as set by manufacturer. By setting this cut-off at 5.0, specificity improved significantly without affecting sensitivity. External validation of this new cut-off at 5.0 in triple-positive scrapings of women selected from the SHENCCASTII database revealed that 22/24 histological normal cases now tested HPV-negative in the Cervista HPV HR test, while CIN2+ lesions remained HPV-positive. The intra-laboratory reproducibility of the Cervista HPV HR test (n = 510 showed a concordance of 92% and 93% for cut-off 1.93 and 5.0 (κ = 0.83 and κ = 0.84, p<0.001 and inter-laboratory agreement of the Cervista HPV HR test was 90% and 93% for cut-off 1.93 and 5.0 (κ = 0.80 and κ = 0.85, p<0.001. In conclusion, the specificity of the Cervista HPV HR test could be improved significantly by increasing the second cut-off from 1.93 to 5.0, without affecting the sensitivity of the test in a population-based screening setting.

  5. Alzheimer’s Disease Dementia as the Diagnosis Best Supported by the Cerebrospinal Fluid Biomarkers: Difference in Cut-Off Levels from Thai Experience

    Directory of Open Access Journals (Sweden)

    V. Senanarong

    2012-01-01

    Full Text Available Objectives. To determine how beta-amyloid 1-42 (Aβ 1-42, total tau (tTau, and phosphorylated tau (pTau levels in CSF behave in a cohort of Thai patients from the Memory Clinic in Bangkok, Thailand. Methods. During 2009–2011, twenty eight subjects from the memory clinic at Siriraj Hospital had CSF analysis for AD biomarkers. Aβ 1-42, tTau, and pTau (at amino acid 181 were measured in CSF by ELISA technique. Results. Mean of Thai mental state examination (TMSE of 28 Thai cohort was 16.48 (6.63. Fourteen had AD, ten had non-AD dementia, and four non-cases were those with subjective memory complaint (SMC without dementia. Mean CSF Aβ 1-42, tTau, ptau (181, and pTau/Aβ 1-42 in the AD group were 241.36 (60.14 pg/mL, 222.79 (212.24 pg/mL, 40.79 (27.84 pg/mL, and 0.18 (0.12 accordingly. Mean CSF Aβ 1-42, tTau, pTau (181, and pTau/Aβ 1-42 in the non-AD dementia group were 430.40 (125.18 pg/mL, 349.30 (692.16 pg/mL, 36.80 (14.90 pg/mL, and 0.09 (0.04 accordingly. Mean CSF Aβ 1-42, tTau, pTau (181, and pTau/Aβ 1-42 in the non-cases with SMC without dementia were 499.75 (93.44 pg/mL, 137.25 (62.74 pg/mL, 31.75 (17.48 pg/mL, and 0.06 (0.02. There is significant difference (P<0.05 among the 3 groups in CSF Aβ 1-42 and pTau/Aβ 1-42. We propose mean + 1.5 SD of CSF Aβ 1-42 in AD group (331.57 pg/mL to be the cut-off point in Thai subjects. Conclusion. There are significant different in CSF Aβ 1-42 and CSF p-tau/Aβ 1-42 among those with AD, non-AD dementia and non cases with SMC without dementia in Thai cohort. Cut-off point of CSF Aβ 1-42 of 331.57 pg/mL is suggested in Thai study.

  6. Cut off from supplies - sulfate exhaustion and implications for methane emissions in a brackish rewetted peatland after separation from the coast

    Science.gov (United States)

    Koebsch, Franziska; Liu, Bo; Schmiedinger, Iris; Spitzy, Alejandro; Köhler, Stefan; Koch, Marian; Jurasinski, Gerald; Gehre, Matthias; Sachs, Torsten; Böttcher, Michael

    2016-04-01

    Coastal ecosystems are at the interface between marine and freshwater and exhibit a special geochemistry. We investigate the S and C geochemistry of a coastal, degraded fen peatland. The site has been cut off from the Baltic Sea since 1995 and was rewetted with freshwater from the surrounding catchment in 2010. Despite of locally high pore water sulfate (SO42-) concentrations, the fen turned into a strong source for methane (CH4) with annual budgets up to 0.26±0.06 kg m-2 (Hahn et al. 2015). To reconcile this apparent contradiction we use concentration patterns and stable isotope signatures of water, SO42-, pyrite, dissolved carbon, and CH4 (δ2H, δ13C, δ18O, δ34S) along a transect with increasing distance to the Baltic coastline (300-1500 m). The current peatland geochemistry is characterized by a combination of relict signals reflecting former brackish water intrusion events and indicators of recent human activities such as internal eutrophication and increasing freshwater contribution. The shallow peat layer (depth mostly ≤ 55 cm) exhibited a pronounced vertical gradient with a freshwater-front lying on top of the brackish water layer. S geochemistry was decoupled from present brackish water distribution as marine SO42- was almost completely biotically reduced and converted to pyrite. The remaining pore water SO42- pool was remarkably 34S-enriched in relation to Baltic Sea SO42- (up to +86.4 and +21‰, respectively) and also δ34S-values of pyrite were comparatively high (+4.8‰), thereby demonstrating a distinct reservoir effect under closed-system conditions. However, one of the profiles situated 1150 m from the Baltic Sea coast line exhibited a contrasting S pattern with pronounced excess of isotopically lighter SO42- at depth (up to 32.8 mM and +22.7‰). We hypothesize, that local groundwater seeps might provide electron acceptors such as NO3- for the contemporary oxidation of pyrite. δ13C in DIC exhibited a pronounced vertical shift from -23.9

  7. Cut off values of laser fluorescence for different storage methods at different time intervals in comparison to frozen condition: A 1 year in vitro study

    Directory of Open Access Journals (Sweden)

    Rudra Kaul

    2014-01-01

    Full Text Available Aims: The aim of the following study is to evaluate the change in laser fluorescence (LF values for extracted teeth stored in different solutions over 1 year period, to give cut-off values for different storage media at different time intervals to get them at par with the in vivo conditions and to see which medium gives best results with the least change in LF values and while enhancing the validity of DIAGNOdent in research. Materials and Methods: Ninety extracted teeth selected, from a pool of frozen teeth, were divided into nine groups of 10 each. Specimens in Groups 1-8 were stored in 1% chloramine, 10% formalin, 10% buffered formalin, 0.02% thymol, 0.12% chlorhexidine, 3% sodium hypochlorite, a commercially available saliva substitute-Wet Mouth (ICPA Pharmaceuticals and normal saline respectively at 4°C. The last group was stored under frozen condition at −20°C without contact with any storage solution. DIAGNOdent was used to measure the change the LF values at day 30, 45, 60, 160 and 365. Statistical Analysis Used: The mean change in LF values in different storage mediums at different time intervals were compared using two-way ANOVA. Results: At the end of 1 year, significant decrease in fluorescence (P < 0.05 was observed in Groups 1-8. Maximum drop in LF values occurred between day 1 and 30. Group 9 (frozen specimens did not significantly change their fluorescence response. Conclusions: An inevitable change in LF takes place due to various storage media commonly used in dental research at different time intervals. The values obtained from our study can remove the bias caused by the storage media and the values of LF thus obtained can hence be conveniently extrapolated to the in vivo condition.

  8. Cut off values of laser fluorescence for different storage methods at different time intervals in comparison to frozen condition: A 1 year in vitro study

    Science.gov (United States)

    Kaul, Rudra; Kaul, Vibhuti; Farooq, Riyaz; Wazir, Nikhil Dev; Khateeb, Shafayat Ullah; Malik, Altaf H; Masoodi, Ajaz Amin

    2014-01-01

    Aims: The aim of the following study is to evaluate the change in laser fluorescence (LF) values for extracted teeth stored in different solutions over 1 year period, to give cut-off values for different storage media at different time intervals to get them at par with the in vivo conditions and to see which medium gives best results with the least change in LF values and while enhancing the validity of DIAGNOdent in research. Materials and Methods: Ninety extracted teeth selected, from a pool of frozen teeth, were divided into nine groups of 10 each. Specimens in Groups 1-8 were stored in 1% chloramine, 10% formalin, 10% buffered formalin, 0.02% thymol, 0.12% chlorhexidine, 3% sodium hypochlorite, a commercially available saliva substitute-Wet Mouth (ICPA Pharmaceuticals) and normal saline respectively at 4°C. The last group was stored under frozen condition at −20°C without contact with any storage solution. DIAGNOdent was used to measure the change the LF values at day 30, 45, 60, 160 and 365. Statistical Analysis Used: The mean change in LF values in different storage mediums at different time intervals were compared using two-way ANOVA. Results: At the end of 1 year, significant decrease in fluorescence (P < 0.05) was observed in Groups 1-8. Maximum drop in LF values occurred between day 1 and 30. Group 9 (frozen specimens) did not significantly change their fluorescence response. Conclusions: An inevitable change in LF takes place due to various storage media commonly used in dental research at different time intervals. The values obtained from our study can remove the bias caused by the storage media and the values of LF thus obtained can hence be conveniently extrapolated to the in vivo condition. PMID:24778506

  9. Burst of reactive oxygen species (ROS in pedicel mediated fruit abscission after carbohydrate supply was cut off in longan (Dimocarpus longan

    Directory of Open Access Journals (Sweden)

    Ziqin eYang

    2015-05-01

    Full Text Available Cutting off carbohydrate supply to longan (Dimocarpus longan Lour. fruit by girdling and defoliation or by detachment induced 100% abscission within a few days. We used these treatments to study the involvement of reactive oxygen species (ROS in fruit abscission. Girdling plus defoliation decreased sugar concentrations in the fruit and pedicel and depleted starch grains in the chloroplasts in the cells of abscission zone. Prior to the occurrence of intensive fruit abscission, there was a burst in ROS in the pedicel, which peaked at 1 day after treatment (DAT, when H2O2 in the abscission zone was found to be chiefly located along the plasma membrane (PM. H2O2 was found exclusively in the cell walls 2 DAT, almost disappeared 3 DAT, and reappeared in the mitochondria and cell walls 4 DAT. Signs of cell death such as cytoplasm breakdown were apparent from 3 DAT. The burst of ROS coincided with a sharp increase in the activity of PM-bound NADPH oxidase in the pedicel. At the same time, activities of antioxidant enzymes including superoxide dismutase (SOD, catalase and peroxidase (POD were all increased by the treatment and maintained higher than those in the control. Accompanying the reduction in H2O2 abundance, there was a sharp decrease in PM-bound NADPH oxidase activity after 1 DAT in the treated fruit. H2O2 scavenger dimethylthiourea (DMTU, 1 g L-1 significantly inhibited fruit abscission in detached fruit clusters and suppressed the increase in cellulase activity in the abscission zone. These results suggest that fruit abscission induced by carbohydrate stress is mediated by ROS. Roles of ROS in regulating fruit abscission were discussed in relation to its subcellular distribution.

  10. The role of hs-CRP, D-dimer and fibrinogen in differentiating etiological subtypes of ischemic stroke.

    Science.gov (United States)

    Liu, Li-Bin; Li, Mu; Zhuo, Wen-Yan; Zhang, Yu-Sheng; Xu, An-Ding

    2015-01-01

    The aim of this study was to evaluate the diagnostic value of the serum biochemical markers high-sensitivity C-reactive protein (hs-CRP), D-dimer (DD) and fibrinogen (Fg) in differentiating etiological subtypes of ischemic stroke. This study was a retrospective case-only study, consecutively including patients with acute ischemic stroke. All patients were classified into subtypes using the TOAST classification system. A total of 317 patients were evaluated. Hs-CRP and DD levels were significantly different among the subtypes and were the highest in CE, followed by LAA and SAA; no significant difference between the subtypes was found for Fg. Hs-CRP > 6.96 mg/L was classified as the CE subtype, with a sensitivity of 41% and a specificity of 74%; DD > 791.30 ng/mL was classified as CE, with a sensitivity of 58% and a specificity of 78%. The combination of hs-CRP and DD classification as CE yielded a sensitivity of 65% and a specificity of 91%. DD > 791.30 ng/mL was considered an independent predictive factor of CE. Hs-CRP and DD could be useful for identifying the etiological subtypes of acute ischemic stroke, especially for predicting CE. The diagnostic value of DD was higher than that of hs-CRP.

  11. Residual vein thrombosis and D-dimer for optimizing duration of anticoagulation in idiopathic deep vein thrombosis.

    Science.gov (United States)

    Malato, Alessandra; Saccullo, Giorgia; Iorio, Alfonso; Ageno, Walter; Siragusa, Sergio

    2010-01-01

    Long-term anticoagulant treatment is highly effective in preventing recurrent Venous Thrombo-Embolism (VTE) in patients with idiopathic Deep Vein Thrombosis (DVT) of the lower limbs, though associated with an increased risk for major bleeding that may offset the benefits of anticoagulation. Accordingly to recent guidelines, patients with idiopathic DVT should be treated for at least 3 months and then should be evaluated for the risk-benefit ratio of long-term therapy. However, such 'time for decision' is often unclear and the optimal duration of VKA remains debatable. In recent studies, markers for the assessment of the individual risk for recurrent thrombosis have been proposed, which can be of help to establish the optimal duration of VKA treatment; among them, the D-dimer (D-d) assay and the Residual Vein Thrombosis (RVT) assessment by Compression Ultra-Sonography (CUS) were shown to be the most suitable. Studies' results showed that negative results of these parameters after 3 to 6 months of therapy, identify a group of patients at low-risk for recurrent thrombosis in whom VKA treatment can be withheld. In the present review we will discuss advantages and potential limits of using these individual markers for the management of patients with a first episode of DVT of the lower limbs.

  12. Impact analysis of different cut-off plans on river floods%不同裁弯取直方案对河道行洪影响分析

    Institute of Scientific and Technical Information of China (English)

    郭志学; 钟友胜; 吕伟

    2014-01-01

    T wo-dimensional numerical models were used to analyze the impacts of tw o cut-off plans on river floods in the up-stream of Fu River in Chengdu City. T he first cut-off plan assigned the elevation difference of the curve reach to the whole riv-er, and the second cut-off plan assigned t he elevation difference to one step-fall. The results show ed that ( 1) both cut-off plans can decrease the wat er level and increase the velocity in the upstream of orthodontic curved river channel and w eaken the flow dynamics in the old river channel; ( 2) the first cut-off plan has higher w eakening impacts on the flow discharge and hydrody-namic parameters in the old river channel than the second cut- off plan; ( 3) the second cut-off plan can cause high velocity in the local area, w hich is disadvantageous to the river channel erosion and has apparent noise pollution; and ( 4) the first plan is similar to the natural cut-off river progress by assigning the elevation difference to the w hole river channel therefore it is more reasona-ble.%采用二维数学模型,对成都市府河上游段河道裁弯取直工程进行了对比分析,探讨了弯颈落差全河段分摊和设置集中跌落两种不同裁弯取直方案对河道行洪的影响。结果表明,不同裁弯取直方案均会造成畸弯河道上游主槽水位降低和流速的增加,并引起老河湾水流动力的减弱;落差分摊方案对老河湾分流量及水流动力参数的消弱作用更大,上游河道水位降低更为明显;从流速沿程分布规律来看,设置集中跌落的裁弯取直方案将引起局部河段流速过高,对河道冲刷安全不利,且存在明显的噪声污染。但是,落差分摊方案将弯颈落差通过工程措施直接分摊到整治河段范围,更接近自然裁弯取直的河道演变过程,因此该工程方案更为合理。

  13. Modeling and analysis on spark discharge of capacitive circuit with cut-off type protection%截止型保护方式下容性电路短路火花放电模型及分析

    Institute of Scientific and Technical Information of China (English)

    于月森; 张望; 孟庆海; 伍小杰

    2013-01-01

    提出截止型输出短路保护方式下本质安全型开关变换器火花放电的容性等效电路模型.通过在IEC火花试验装置上进行试验,研究截止型保护方式下容性电路火花放电的规律,建立截止型保护方式下容性电路火花放电数学模型.分析与实验表明,建立的数学模型与实际基本相符;截止放电模式与自然放电模式在火花放电规律方面有显著的差异;截止放电模式下减小截止时间和减小电容值均能提高本质安全性能,但在不同取值范围效果不同.%It was proposed that the equivalent circuit model of intrinsically safe switching converter with cut-off type output short circuit protection was capacitive circuit with cut-off type protection. The discharge characteristic of the capacitive circuit with cut-off type protection was found out through a large number of spark discharge experiment in IEC spark test apparatus. The spark discharge mathematical model was established. Analysis and experimental results show that mathematical model is consistent with the reality. The spark discharge laws are significant differences between natural discharge mode and cut-off discharge mode. Under natural discharge mode, both shortening the discharge time and reducing the capacitance value could improve the performance of intrinsical safety, but there are different effects in different value range.

  14. 中国哈萨克族成人代谢综合征腰围适宜切点研究%The optimum cut-off points of waist circumference for identifying metabolic syndrome in Kazak adults

    Institute of Scientific and Technical Information of China (English)

    高静; 王宁; 王建疆; 娜孜姑丽; 谢自敬; 毛新民; 李琳琳

    2010-01-01

    探讨哈萨克族成人代谢综合征(MS)诊断的腰围适宜切点.选取2 052例哈萨克族成人,依据国际糖尿病联盟标准,检出两个以上MS组分的假阳性和假阴性率均较低的腰围切点为男性≥99 cm,女性≥88 cm.建议哈萨克族成人以此切点作为MS的检出标准.%The optimum cut-off point of waist circumference for identifying metabolic syndrome(MS)in Kazak was investigated.Based on Internationul Diabetes Eederation.2052 Kazak adults were analysed.At the cut-off point of waist circumference(≥199 cm for men,≥88 cm for women),the rates of false positive and negative for identifying MS were reduced to a minimum.The two cut-off points were possibly appropriate for identifying MS in Kazak.

  15. D-dimer Test

    Science.gov (United States)

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  16. Usefulness of Clinical Prediction Rules, D-dimer, and Arterial Blood Gas Analysis to Predict Pulmonary Embolism in Cancer Patients

    Directory of Open Access Journals (Sweden)

    Shazia Awan

    2017-03-01

    Full Text Available Objectives: Pulmonary embolism (PE is seven times more common in cancer patients than non-cancer patients. Since the existing clinical prediction rules (CPRs were validated predominantly in a non-cancer population, we decided to look at the utility of arterial blood gas (ABG analysis and D-dimer in predicting PE in cancer patients. Methods: Electronic medical records were reviewed between December 2005 and November 2010. A total of 177 computed tomography pulmonary angiograms (CTPAs were performed. We selected 104 individuals based on completeness of laboratory and clinical data. Patients were divided into two groups, CTPA positive (patients with PE and CTPA negative (PE excluded. Wells score, Geneva score, and modified Geneva score were calculated for each patient. Primary outcomes of interest were the sensitivities, specificities, positive, and negative predictive values for all three CPRs. Results: Of the total of 104 individuals who had CTPAs, 33 (31.7% were positive for PE and 71 (68.3% were negative. There was no difference in basic demographics between the two groups. Laboratory parameters were compared and partial pressure of oxygen was significantly lower in patients with PE (68.1 mmHg vs. 71 mmHg, p = 0.030. Clinical prediction rules showed good sensitivities (88−100% and negative predictive values (93−100%. An alveolar-arterial (A-a gradient > 20 had 100% sensitivity and negative predictive values. Conclusions: CPRs and a low A-a gradient were useful in excluding PE in cancer patients. There is a need for prospective trials to validate these results.

  17. Antimicrobial Susceptibility of Flavobacterium psychrophilum from Chilean Salmon Farms and their Epidemiological Cut-off Values using Agar Dilution and Disk Diffusion Methods

    Directory of Open Access Journals (Sweden)

    Claudio D Miranda

    2016-11-01

    Full Text Available Flavobacterium psychrophilum is the most important bacterial pathogen for freshwater farmed salmonids in Chile. The aims of this study were to determine the susceptibility to antimicrobials used in fish farming of Chilean isolates and to calculate their epidemiological cut-off (COWT values. A number of 125 Chilean isolates of F. psychrophilum were isolated from reared salmonids presenting clinical symptoms indicative of flavobacteriosis and their identities were confirmed by 16S rRNA polymerase chain reaction. Susceptibility to antibacterials was tested on diluted Mueller-Hinton by using an agar dilution MIC method and a disk diffusion method. The COWT values calculated by Normalised Resistance Interpretation (NRI analysis allow isolates to be categorized either as wild-type fully susceptible (WT or as manifesting reduced susceptibility (NWT. When MIC data was used, NRI analysis calculated a COWT of ≤ 0.125 μg mL-1, ≤ 2 μg mL-1 and ≤ 0.5 μg mL-1 for amoxicillin, florfenicol and oxytetracycline, respectively. For the quinolones, the COWT were ≤1 μg mL-1, ≤ 0.5 μg mL-1 and ≤ 0.125 μg mL-1 for oxolinic acid, flumequine and enrofloxacin respectively. The disc diffusion data sets obtained in this work were extremely diverse and were spread over a wide range. For the quinolones there was a close agreement between the frequencies of NWT isolates calculated using MIC and disc data. For oxolinic acid, flumequine and enrofloxacin the frequencies were 45, 39 and 38% using MIC data, and 42, 41 and 44%, when disc data were used. There was less agreement with the other antimicrobials, because NWT frequencies obtained using MIC and disc data respectively, were 24% and 10% for amoxicillin, 8% and 2% for florfenicol and 70% and 64% for oxytetracycline. Considering that the MIC data was more precise than the disc diffusion data, MIC determination would be the preferred method for susceptibility testing for this species and the NWT frequencies

  18. Combined use of the National Early Warning Score and D-dimer levels to predict 30-day and 365-day mortality in medical patients

    DEFF Research Database (Denmark)

    Nickel, Christian H; Kellett, John; Cooksley, Tim;

    2016-01-01

    AIM: To investigate the combined use of NEWS and D-dimer levels to predict the 30-day and 365-day mortality rates of a cohort of Danish patients with complete follow-up. METHODS: Post-hoc retrospective observational study of acutely admitted medical patients aged 18 years or older who had D......-dimer measured within 6h after arrival to two medical admission units in Denmark. RESULTS: The final study population consisted of 1201 patients with a median age of 65.0 years (range 18.0-107.0 years), and 44.7% were of male sex. Four patients (0.3%) died within 24h of admission, 69 (5.7%) within 30 days...... and 198 (16.5%) within 365 days. On admission, 576 (48%) patients had a NEWS≥3 - of these 441 had a D-dimer≥0.50mgL(-1): 55 (12.5%) of these patients died within 30 days, compared with 5 (3.7%) of the 135 patients with a D-dimer

  19. Dual energy CT pulmonary blood volume assessment in acute pulmonary embolism - correlation with D-dimer level, right heart strain and clinical outcome

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, Ralf W.; Frellesen, Claudia; Schell, Boris; Lehnert, Thomas; Jacobi, Volkmar; Vogl, Thomas J.; Kerl, J.M. [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Frankfurt (Germany); Renker, Matthias [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Frankfurt (Germany); Medical University of South Carolina, Heart and Vascular Center, Ashley River Tower, Charleston, SC (United States); Ackermann, Hanns [Clinic of the Goethe University, Department of Biostatistics and Mathematical Modelling, Frankfurt (Germany); Schoepf, U.J. [Medical University of South Carolina, Heart and Vascular Center, Ashley River Tower, Charleston, SC (United States)

    2011-09-15

    To investigate the role of perfusion defect (PD) size on dual energy CT pulmonary blood volume assessment as predictor of right heart strain and patient outcome and its correlation with d-dimer levels in acute pulmonary embolism (PE). 53 patients with acute PE who underwent DECT pulmonary angiography were retrospectively analyzed. Pulmonary PD size caused by PE was measured on DE iodine maps and quantified absolutely (VolPD) and relatively to the total lung volume (RelPD). Signs of right heart strain (RHS) on CT were determined. Information on d-dimer levels and readmission for recurrent onset of PE and death was collected. D-dimer level was mildly (r = 0.43-0.47) correlated with PD size. Patients with RHS had significantly higher VolPD (215 vs. 73 ml) and RelPD (9.9 vs. 2.9%) than patients without RHS (p < 0.003). There were 2 deaths and 1 readmission due of PE in 18 patients with >5% RelPD, while no such events were found for patients with <5% RelPD. Pulmonary blood volume on DECT in acute PE correlates with RHS and appears to be a predictor of patient outcome in this pilot study. (orig.)

  20. Preparation and Analysis of Lyophilization Characterization of Human D-dimer%人D-二聚体的制备及其冻干性质的分析

    Institute of Scientific and Technical Information of China (English)

    武建伟; 才蕾; 王继华; 唐时幸

    2014-01-01

    以人源纤维蛋白原为原材料制备D-二聚体,将其制成冻干品并分析其冻干性质。使用凝血酶、Factor XIIIa酶解纤维蛋白原,获得交联纤维蛋白。经纤溶酶降解交联纤维蛋白,生成纤维蛋白降解产物。超滤除去纤维蛋白降解产物中的小分子物质,可获得较高纯度的D-二聚体。通过筛选和优化冻干方案,将D-二聚体制备成冻干品。经检测可知,D-二聚体冻干品可在37℃稳定保存12 d;复溶后在25℃稳定保存8 d;复溶后在4℃稳定保存30 d;复溶时,常用复溶溶剂对其复溶后的活性检测无明显影响。%D-dimer is formed by sequential action of 3 enzymes from fibrinogen. After producing D-dimer, we did the research on its lyophilization process. To produce cross-linked fibrin, fibrinogen was digested by thrombin and Factor XIIa. Then, fibrin degradation products (FDP)was prepared from cross-linked fibrin being degraded by plasmin. D-dimer was purified from FDP through ultrafiltration and prepared into lyophilized powder. By optimizing the lyophilization program, lyophilized D-dimer was stable for at least 12 days at 37℃, stable for at least 8 days at 25℃ and 30 days at 4℃ after reconstitution, and not different when being dissolved by different solvent.The preparation system established in this research is feasible and efficient. Depend on its stability, lyophilized D-dimer could be provided as biological raw materials for further research.

  1. {sup 18}F-FDG PET/CT for detection of malignant peripheral nerve sheath tumours in neurofibromatosis type 1: tumour-to-liver ratio is superior to an SUV{sub max} cut-off

    Energy Technology Data Exchange (ETDEWEB)

    Salamon, Johannes [University Medical Centre Hamburg-Eppendorf, Department of Diagnostic and Interventional Radiology, Hamburg (Germany); University Hospital Hamburg-Eppendorf, Department of Diagnostic and Interventional Radiology, Hamburg (Germany); Veldhoen, Simon [University Medical Centre Hamburg-Eppendorf, Department of Diagnostic and Interventional Radiology, Hamburg (Germany); University Medical Centre Wuerzburg, Department of Diagnostic and Interventional Radiology, Wuerzburg (Germany); Apostolova, Ivayla [Otto-von-Guericke University, Department of Radiology and Nuclear Medicine, Magdeburg (Germany); Bannas, Peter; Yamamura, Jin; Herrmann, Jochen; Adam, Gerhard; Derlin, Thorsten [University Medical Centre Hamburg-Eppendorf, Department of Diagnostic and Interventional Radiology, Hamburg (Germany); Friedrich, Reinhard E. [University Medical Centre Hamburg-Eppendorf, Department of Oral and Maxillofacial Surgery, Hamburg (Germany); Mautner, Victor F. [University Medical Centre Hamburg-Eppendorf, Department of Neurology, Hamburg (Germany)

    2014-02-15

    To evaluate the usefulness of normalising intra-tumour tracer accumulation on {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) to reference tissue uptake for characterisation of peripheral nerve sheath tumours (PNSTs) in neurofibromatosis type 1 (NF1) compared with the established maximum standardised uptake value (SUVmax) cut-off of >3.5. Forty-nine patients underwent FDG PET/CT. Intra-tumour tracer uptake (SUVmax) was normalised to three different reference tissues (tumour-to-liver, tumour-to-muscle and tumour-to-fat ratios). Receiver operating characteristic (ROC) analyses were used out to assess the diagnostic performance. Histopathology and follow-up served as the reference standard. Intra-tumour tracer uptake correlated significantly with liver uptake (r{sub s} = 0.58, P = 0.016). On ROC analysis, the optimum threshold for tumour-to-liver ratio was >2.6 (AUC = 0.9735). Both the SUVmax cut-off value of >3.5 and a tumour-to-liver ratio >2.6 provided a sensitivity of 100 %, but specificity was significantly higher for the latter (90.3 % vs 79.8 %; P = 0.013). In patients with NF1, quantitative {sup 18}F-FDG PET imaging may identify malignant change in neurofibromas with high accuracy. Specificity could be significantly increased by using the tumour-to-liver ratio. The authors recommend further evaluation of a tumour-to-liver ratio cut-off value of >2.6 for diagnostic intervention planning. (orig.)

  2. Predictive Values of Body Mass Index and Waist Circumference for Risk Factors of Certain Related Diseases in Chinese Adults - Study on Optimal Cut-off Points of Body Mass Index and Waist Circumference in Chinese Adults

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    For prevention of obesity in Chinese population, it is necessary to define the optimal range of healthy weight and the appropriate cut-off points of BMI and waist circumference for Chinese adults. The Working Group on Obesity in China under the support of International Life Sciences Institute Focal point in China organized a meta-analysis on the relation between BMI, waist circumference and risk factors of related chronic diseases (e. g.,high diabetes, diabetes mellitus, and lipoprotein disorders). Methods 13 population studies in all met the criteria for enrollment, with data of 239 972 adults (20-70 year) surveyed in the 1990s. Data on waist circumference was available for 111411 persons and data on serum lipids and glucose were available for more than 80 000. The study populations located in 21provinces, municipalities and autonomous regions in mainland China as well as in Taiwan. Each enrolled study provided data according to a common protocol and uniform format. The Center for data management in Department of Epidemiology, Fu Wai Hospital was responsible for statistical analysis. Results and conclusion The prevalence of hypertension, diabetes, dyslipidemia and clustering of risk factors all increased with increasing levels of BMI or waist circumference. BMI at 24 with best sensitivity and specificity for identification of the risk factors, was recommended as the cut-off point for overweight, BMI at 28 which may identify the risk factors with specificity around 90 % was recommended as the cut-off point for obesity. Waist circumference beyond 85 cm for men and beyond 80 cm for women were recommended as the cut-off points for central obesity.Analysis of population attributable risk percent illustrated that reducing BMI to normal range (<24) could prevent 45%-50% clustering of risk factors. Treatment of obese persons (BMI ≥ 28)with drugs could prevent 15%-17% clustering of risk factors. The waist circumference controlled under 85 cm for men and under 80 cm for

  3. Design of Cut-off Ditch at Valley-type Small Waste Sanitary Landfill Site in Southwest China%西南地区山谷型小型垃圾填埋场截洪沟设计

    Institute of Scientific and Technical Information of China (English)

    邹许鑫; 吕燕; 尹滔

    2012-01-01

    对西南地区山谷型小型垃圾填埋场截洪沟设计展开探讨,结合相关规范优选适用于西南地区的截洪沟设计充满度、设计流速、径流系数等关键设计参数,对截洪沟的流量计算、断面选择、沟壁沟底材料及基础设计、出水口及转弯段的设计、整体平面布置等进行讨论,提出三种优化截洪沟断面.通过截洪沟的优化设计可实现清污分流,降低渗滤液产量,减少雨水对垃圾渗滤液收集及处理系统的冲击,降低垃圾渗滤液处理成本,确保垃圾填埋场正常、安全运行.%The design of cut-off ditch at valley-type small landfill site in the southwest China is explored. The design parameters of cut-off ditch applicable to the southwest China, such as design filling degree, design flow, runoff coefficient and other key design parameters are selected according to the related codes. The flow calculation, cross section selection, materials and foundation design for the ditch walls and bottom, design of outlet and curved segment and overall layout are discussed. Three kinds of optimized cross sections of cut-off ditch are proposed. The optimization design of cut-off dilch can achieve the separation of rainwater and sewage, reduce the leachate production, mitigate the impact of rainwater on collection and treatment systems of landfill leachate, thus reducing the treatment cost of landfill leachate and ensuring the normal and safe operation of landfill site.

  4. Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese

    Science.gov (United States)

    Lee, C. H.; Shih, A. Z. L.; Woo, Y. C.; Fong, C. H. Y.; Leung, O. Y.; Janus, E.; Cheung, B. M. Y.; Lam, K. S. L.

    2016-01-01

    Background The optimal reference range of homeostasis model assessment of insulin resistance (HOMA-IR) in normal Chinese population has not been clearly defined. Here we address this issue using the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS), a prospective population-based cohort study with long-term follow-up. Material & Methods In this study, normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) were defined according to the 1998 World Health Organization criteria. Dysglycemia referred to IFG, IGT or T2DM. This study comprised two parts. Part one was a cross-sectional study involving 2,649 Hong Kong Chinese subjects, aged 25–74 years, at baseline CRISPS-1 (1995–1996). The optimal HOMA-IR cut-offs for dysglycemia and T2DM were determined by the receiver-operating characteristic (ROC) curve. Part two was a prospective study involving 872 subjects who had persistent NGT at CRISPS-4 (2010–2012) after 15 years of follow-up. Results At baseline, the optimal HOMA-IR cut-offs to identify dysglyceia and T2DM were 1.37 (AUC = 0.735; 95% confidence interval [CI] = 0.713–0.758; Sensitivity [Se] = 65.6%, Specificity [Sp] = 71.3%] and 1.97 (AUC = 0.807; 95% CI = 0.777–0.886; Se = 65.5%, Sp = 82.9%) respectively. These cut-offs, derived from the cross-sectional study at baseline, corresponded closely to the 75th (1.44) and 90th (2.03) percentiles, respectively, of the HOMA-IR reference range derived from the prospective study of subjects with persistent NGT. Conclusions HOMA-IR cut-offs, of 1.4 and 2.0, which discriminated dysglycemia and T2DM respectively from NGT in Southern Chinese, can be usefully employed as references in clinical research involving the assessment of insulin resistance. PMID:27658115

  5. Age-Adjusted PSA Levels in Prostate Cancer Prediction: Updated Results of the Tyrol Prostate Cancer Early Detection Program.

    Directory of Open Access Journals (Sweden)

    Isabel Heidegger

    Full Text Available To reduce the number of unnecessary biopsies in patients with benign prostatic disease, however, without missing significant PCa the present study re-evaluates the age-dependent PSA cut-offs in the Tyrol Prostate Cancer (PCa early detection program.The study population included 2225 patients who underwent prostate biopsy due to elevated PSA levels at our department. We divided our patient collective into four age groups: ≤49 years (n = 178, 50-59 years (n = 597, 60-69 years (n = 962 and ≥70 years (n = 488. We simulated different scenarios for PSA cut-off values between 1.25 and 6 ng/mL and fPSA% between 15 and 21% for all four age groups and calculated sensitivity, specificity, confidence intervals and predictive values.PCa was detected in 1218 men (54.7%. We found that in combination with free PSA ≤21% the following PSA cut-offs had the best cancer specificity: 1.75 ng/ml for men ≤49 years and 50-59 years, 2.25 ng/ml for men aged 60-69 years and 3.25 ng/ml for men ≥70 years. Using these adjusted PSA cut-off values all significant tumors are recognized in all age groups, yet the number of biopsies is reduced. Overall, one biopsy is avoided in 13 to 14 men (number needed to screen = 13.3, reduction of biopsies = 7.5% when decision regarding biopsy is done according to the "new" cut-off values instead of the "old" ones. For the different age groups the number needed to screen to avoid one biopsy varied between 9.2 (≤49 years and 17.4 (50-59 years.With "new", fine-tuned PSA cut-offs we detect all relevant PCa with a significant reduction of biopsies compared to the "old" cut-off values. Optimization of age-specific PSA cut-offs is one step towards a smarter strategy in the Tyrol PCa Early Detection Program.

  6. Von Willebrand Factor, ADAMTS13 and D-Dimer Are Correlated with Different Levels of Nephropathy in Type 1 Diabetes Mellitus.

    Directory of Open Access Journals (Sweden)

    Caroline Pereira Domingueti

    Full Text Available We have investigated whether von Willebrand factor, ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13, and D-Dimer were associated with different levels of renal function in patients with type 1 diabetes. Patients were classified according to level of renal function through estimated glomerular filtration rate: ≥90 and <130mL/min/1,73m2, n=52 (control group, ≥60 and <90mL/min/1,73m2, n=29 (mild renal dysfunction group, <60mL/min/1,73m2, n=28 (severe renal dysfunction group; and through urinary albumin excretion: normoalbuminuria, microalbuminuria and macroalbuminuria. Von Willebrand factor, ADAMTS13, and D-Dimer plasma levels were determined by enzyme-linked immunosorbent assay. ADAMTS13 activity was determined by fluorescence resonance energy transfer assay. Von Willebrand factor levels were increased in patients with mild (P=0.001 and severe (P<0.001 renal dysfunction as compared to the control group. ADAMTS13 levels were also increased in mild (P=0.029 and severe (P=0.002 renal dysfunction groups in comparison to the control group, while ADAMTS13 activity was increased only in the severe renal dysfunction group as compared to the control group (P=0.006. No significant differences were observed among the groups regarding von Willebrand factor/ADAMTS13 ratio. ADAMTS13 activity/ADAMTS13 levels ratio was reduced in patients with mild (P=0.013 and severe (P=0.015 renal dysfunction as compared to the control group. D-Dimer levels were increased in patients with mild (P=0.006 and severe (P<0.001 renal dysfunction as compared to the control group; it was also higher in patients with severe renal dysfunction as compared to the mild renal dysfunction group (P=0.019. Similar results were found for albuminuria classification. Increased von Willebrand factor, ADAMTS13, and D-Dimer levels and decreased ADAMTS13 activity/ADAMTS13 levels ratio are associated with renal dysfunction in patients with type 1 diabetes

  7. Thickness-Independent Ultrasonic Imaging Applied to Abrasive Cut-Off Wheels: An Advanced Aerospace Materials Characterization Method for the Abrasives Industry. A NASA Lewis Research Center Technology Transfer Case History

    Science.gov (United States)

    Roth, Don J.; Farmer, Donald A.

    1998-01-01

    Abrasive cut-off wheels are at times unintentionally manufactured with nonuniformity that is difficult to identify and sufficiently characterize without time-consuming, destructive examination. One particular nonuniformity is a density variation condition occurring around the wheel circumference or along the radius, or both. This density variation, depending on its severity, can cause wheel warpage and wheel vibration resulting in unacceptable performance and perhaps premature failure of the wheel. Conventional nondestructive evaluation methods such as ultrasonic c-scan imaging and film radiography are inaccurate in their attempts at characterizing the density variation because a superimposing thickness variation exists as well in the wheel. In this article, the single transducer thickness-independent ultrasonic imaging method, developed specifically to allow more accurate characterization of aerospace components, is shown to precisely characterize the extent of the density variation in a cut-off wheel having a superimposing thickness variation. The method thereby has potential as an effective quality control tool in the abrasives industry for the wheel manufacturer.

  8. On-line cut-off technique and organic modifier addition aided signal enhancement for trace analysis of carbohydrates in cellulase hydrolysate by ion exclusion chromatography-electrospray ionization mass spectrometry.

    Science.gov (United States)

    Cheng, Cheanyeh; Tsai, Hsiang-Rong; Chang, Kuo-Chung

    2006-06-30

    Paper cellulose has been hydrolyzed with calcium alginate immobilized cellulase to produce carbohydrate products and the three trace sugars, galactose, arabinose, and mannose in the cellulase hydrolysate have been analyzed by HPIEC/ESI-MS. Applying the on-line cut-off technique to the HPIEC/ESI-MS can cut the high concentration glucose off to eliminate its interference on the peaks of minor sugars and enhance their signals from 1.1- to 1.6-fold. However, the on-line post column addition of 15% ethanol to the eluate can increase the signal of the three trace sugars, galactose, arabinose, and mannose up to 17-, 23-, and 11-fold, respectively, and make the corresponding detection limits as 0.04, 0.04, and 0.03 ppm. The accuracies of the quantitative analysis for the three trace sugars with the signal enhanced HPIEC/ESI-MS by the two enhancement methods were larger than 95%. The precisions of the analytical results were also greatly improved by the assistance of the two techniques and were less than 6.5%. The quantitative analysis of the three trace sugars was performed with the internal standard method and the internal standard (IS) was sorbitol. Overall, the signal enhancement of HPIEC/ESI-MS and quantification of the three trace sugars by the on-line cut-off technique and organic modifier addition was successful.

  9. High Voltage Test Power’s Fast Cutting-off Device Based on Infrared%基于红外线的高压试验电源快速切断装置

    Institute of Scientific and Technical Information of China (English)

    胡双双; 周刚; 胡海平; 邱东晓; 金海; 潘克菲

    2015-01-01

    High voltage power system during the test will generate tens of kilovolts or more high-pressure. Therefore,to ensure the safety of persons and equipment is a basic requirement.However,approaches of the traditional use of ropes or fence to seclude the high voltage test area can not protect the safety of personnel and equipment at the root when testing personnel or foreign body mistakenly go in the charged region.This paper presented a program of fast high voltage test power cut-off device based on infrared.It can make audible voice alarm,at the same time quickly cut off high voltage power supply,to ensure the safety of persons and equipment from the source,when testing personnel or foreign objects mistakenly go in the charged region.%提出了一种基于红外线的高压试验电源快速切断的方案,并设计了装置的硬件电路和系统软件。经现场试验,当有人员或异物误入带电区域时,发出声光语音报警的同时快速切断高压电源,从源头上保证人身和设备安全。

  10. An approach for the delineation of a generic cut-off value for local respiratory tract irritation by irritating or corrosive substances as a pragmatic tool to fulfill REACH requirements.

    Science.gov (United States)

    Messinger, H

    2014-04-01

    Under the current European legislation for the Registration, Evaluation, Authorisation and restriction of Chemicals (REACHs) a Derived No Effect Level (DNEL) has to be delineated for acute and chronic inhalation effects. The majority of available experimental studies are performed by the oral route of exposure. Route to route extrapolation poses particular problems for irritating or corrosive substances but the necessity for additional animal studies with inhalation exposure needs to be balanced with the regulatory information requirements. Existing occupational exposure limits (OEL) as surrogate for cut-off limits representing safe exposure under working conditions were grouped under certain criteria for substances that are legally classified in Europe as irritating or corrosive. As a result, it was shown that the OEL for irritating substances in this dataset is not lower than 10mg/m(3) and for corrosives not lower than 1mg/m(3). Under certain conditions these generic limits could be applied as a pragmatic, but still sufficiently reliable and protective upper cut-off limit approach to avoid additional animal tests with irritating or corrosive chemicals. The respective systemic toxicity profiles and physical-chemical properties need to be considered. Specific exclusion criteria for the discussed concept apply.

  11. Study on Spectral Response beyond Cut off of Cs2Te Ultra Violet Photo Cathode%Cs2Te紫外光电阴极带外光谱响应研究

    Institute of Scientific and Technical Information of China (English)

    李晓峰; 姜云龙; 李靖雯; 姬明; 李金沙; 张勤东

    2015-01-01

    With the strong light as the input, the spectral response beyond cut off of the Cs2Te ultraviolet photo cathode is measured. The results show that the spectral response of the Cs2Te cathode beyond cut off is lower, and is several orders of magnitude lower than that within the cutoff. The peak sensitivity of within cutoff can be greater than 40mA/W, but the spectral response beyond cut off can be as low as 10-3mA/W order of magnitude at 550nm wavelength. The divergence of spectral response beyond cut off of Cs2Te ultraviolet photo cathode made with the same process is large. According to the test of three different visible light photo cathode, namely Na2KSb (Cs), K2CsSb and GaAs (Cs-O), it is proved that these three kinds of visible light photo cathode also have certain spectral response. The test data show that the spectral response beyond cut off is related to the size of the work function (positive electron affinity cathode) or the band gap (negative electron affinity cathode). The smaller the work function or the band gap is, the greater the spectral response beyond cut off. The spectral response beyond cut off is a common phenomenon for photo cathode. The reason is that the effect of multiphoton absorption, i.e. multiphoton effect. Because Cs2Te photo cathodes are present spectral response beyond cut off, thus, when solar blind image intensifier adopting Cs2Te photo cathodes is used in the strong sun light or straight to the sun's light, detected signal would be disturbed by the light of the sun, or by the image of the sun like. Thus solar blind image intensifier does not have the sun blind characteristic. In order to make the solar blind ultraviolet image intensifier fully equipped with solar blind characteristic, solar blind filter is needed. Combining solar blind filter with spectral response of Cs2Te cathode beyond cut off, solar blind image intensifier can achieve complete solar blind. So in the practical application of ultra violet detecting, the solar

  12. 虎红平板凝集试验确诊布鲁杆菌病截断值的探讨%Cut-off value of rose bengal plate agglutination test in rapid diagnosis of brucellosis

    Institute of Scientific and Technical Information of China (English)

    马志东; 刘云霞; 李艳红; 李建云

    2013-01-01

    Objective To find out the cut-off value of rose bengal plate agglutination test(RBPT) in rapid diagnosis of brucellosis.Methods From May to June 2009,398 people who came to the outpatient department of Inner Mongolia Center for Endemic Disease Control and Research were diagnosed brucellosis by RBPT and tube agglutination test (SAT).Tube agglutination test as a gold standard,rose bengal plate agglutination test,its authenticity and reliability were evaluated.Results Taking positive predictive value 100.0% as the selection standard,the cut-off value of RBPT was "++" which could be used to diagnose brucellosis.The sensitivity was 83.3%; the specificity was 100.0%; the Youden index was 0.832; and the compliance rote was 89.9%.Conclusion The cut-off value "++" of RBPT to diagnosis brucellosis is worthy of clinical promotion.%目的 探讨虎红平板凝集试验确诊布鲁杆菌病凝集度的截断值.方法 内蒙古地方病防治研究中心门诊部选择2009年5月至2009年6月,进行布鲁杆菌病检查的398人,进行试管凝集试验和虎红平板凝集试验检测,以试管凝集试验为金标准,探讨虎红平板凝集试验诊断布鲁杆菌病的截断值,并对可靠性和真实性进行评价.结果 以阳性预测值100.0%作为筛选标准,虎红平板凝集试验快速确诊布鲁杆菌病的截断值为“++”,以该凝集度强度作为截断值进行布鲁杆菌病诊断,灵敏度为83.3%,特异度为100.0%,约登指数为0.823,符合率为89.9%.结论 以虎红平板凝集试验的“++”作为截断值诊断布鲁杆菌病,值得临床推广.

  13. Clinical Significance of Fibrinogen and D-dimer Detection in Esophageal Cancer%食管癌患者纤维蛋白原与D-二聚体检测的临床意义

    Institute of Scientific and Technical Information of China (English)

    刘瑜; 林晓铭; 池闯; 程德志

    2012-01-01

    目的 检测并研究食管癌患者血浆中纤维蛋白原(FIB)和D-二聚体(D-dimer,DD)的变化及其临床意义.方法 对60例食管癌患者和8例健康人血浆中FIB和D-二聚体进行检测并同临床指标间进行统计学分析.结果 食管癌组血浆中的FIB和D-二聚体水平明显高于正常对照组(P<0.01);同患者的淋巴结转移情况及P-TNM分期有关(P <0.05或P<0.01),而同性别及年龄不相关(P>0.05).结论 食管癌患者的FIB及D-二聚体高于正常,并同淋巴结转移及P-TNM分期相关且与患者的生存期呈明显的负相关.%Objective To explore the clinical significance of fibrinogen and D - dimer detection in esophageal squamous cell cancer. Methods The fibrinogen and D - dimer were detected in 60 esophageal cancer patients and 8 healthy adults, and the data were analyzed with clinical indexes by SPSS. Results Levdel of fibrinogen and D - dimer in esophageal cancer patients were higher than that in healthy group (P 0. 05 ). Conclusion Compared with healthy group, significantly higher serum fibrinogen and D - dimer levels were detected in esophageal cancer patients. There was closely relationship between fibrinogen and D - dimer levels in esophageal cancer patients and lymph node metastases, p - TNM stage,and they were negatively correlated with lifetime.

  14. 蒙古族农牧民代谢综合征诊断的腰围切点观察%Observation of the cut-off point of waist circumference for diagnosing metabolic syndrome in Mongolian peasants and herdsmen

    Institute of Scientific and Technical Information of China (English)

    刘洋; 刘永跃; 王健; 阿尔斯楞; 李永山; 张永红; 佟伟军

    2011-01-01

    Objective To survey the cut-off point of waist circumference for diagnosing metabolic syndrome (MS) in Chinese Mongolian peasants and herdsmen. Methods Based on the IDF consensus worldwide definition of metabolic syndrome (2005), 2589 Mongolia adults aged over 20 years from agricultural and pastoral areas in Tongliao city were enrolled to analyze the Ors of the clustering of MS components at different sizes of waist circumference. The sensitivity , specificity and area under the ROC curve by different cut-off points of waist circumference for identifying at least two components of MS were estimated to find the cut-off points for men and women in Mongolia. Results The Ors of the clustering of MS components were increased significantly with the sizes of waist circumference. The waist circumference( ≥ 84cm for men, ≥81 cm for women) corresponded to the largest area under the ROC curve , namely, at these cut-off points, the rates of sensitivity and specificity for identifying MS were relatively high. Conclusion The cut-points of WC according to IDF criteria are high for men of Mongolia peasant and herdsmen. It should be lowered to 85cm for men and 80cm for women. This recommendation needs to be further confirmed by follow-up studies in Mongolian people.%目的 研究我国蒙古族农牧民代谢综合征(MS)诊断的腰围(WC)适宜切点. 方法 以内蒙古自治区通辽市科左后旗朝鲁吐苏木和奈曼旗固日班花苏木32个自然村2589名年龄大于20岁的蒙古族农牧民为研究对象,以国际糖尿病联盟(IDF) MS全球共识诊断标准为基础,分析蒙古族男女不同WC水平与MS其他组分聚集的关联,检出至少两个组分存在时灵敏度和特异度均较高的WC界限,作为诊断蒙古族农牧民MS的WC切点,并以此计算不同年龄组MS的检出率. 结果 随WC增大,MS组分聚集的OR值显著增高.当男性WC≥84 cm、女性WC≥81 cm时,ROC曲线下面积最大. 结论 IDF标准在蒙古族农牧民男性

  15. PtSi红外探测器截止波长延长研究%Study on Extension of Cut-off Wavelength of PtSi Infrared Detectors

    Institute of Scientific and Technical Information of China (English)

    刘爽; 杨家德; 刘飒; 宁永功; 陈艾

    2001-01-01

    The basic theory of the extension of cut-off wavelength of PtSi infrared detectors is discussed.Three methods are introduced including Tl+ and Ir+ doping, MBE growth of P+layer and B+, In+ low-energy ion-implantation.%讨论了将PtSi红外探测器截止波长延长的理论基础,并介绍了采用在衬底掺入Tl+和Ir+,MBE生长P+层以及低能离子注入B+,In+来延长PtSi红外探测器截止波长的三种方法。

  16. Clinical Application of D dimer in Venous Thromboembolism%D二聚体测定在静脉血栓栓塞中的临床应用

    Institute of Scientific and Technical Information of China (English)

    李恒; 张凯; 黄津; 王毅

    2011-01-01

    @@ 静脉血栓栓塞(venous thromboembolism ,VTE)是临床常见的血栓性疾病,其中最主要的是深静脉血栓栓塞症(deep venous thrombosis ,DVT)和肺栓塞(pulmonary embolism ,PE),因其发病率和致死率均高而倍受国内外医者之重视.D二聚体(D-dimer,D-D)是经凝血酶及因子作用的交联纤维蛋白经纤溶酶降解后产生的终末产物,是反映体内凝血和纤溶的理想分子标志物之一.

  17. Diagnostic and prognostic value of brain natriuretic peptide (BNP) concentrations in very elderly heart disease patients: specific geriatric cut-off and impacts of age, gender, renal dysfunction, and nutritional status.

    Science.gov (United States)

    Blondé-Cynober, F; Morineau, G; Estrugo, B; Fillie, E; Aussel, C; Vincent, J-P

    2011-01-01

    Confirming the presence of heart failure (HF) in geriatric patients is made difficult by the overlapping symptoms with other diseases and by limited access to investigative techniques such as echography, and the clinical signs are either non-constant or difficult to interpret. In this context, BNP measurement could prove highly useful. We determined a cut-off value of BNP for diagnosing HF in geriatric patients and gauged its predictive power in terms of cardiovascular events, dependence and death within a 6-month timeframe. This clinical and biological study was performed in patients, 44 women and 20 men, age>65 years with suspected HF hospitalized in the geriatric unit at Emile-Roux hospital. Echography was performed at baseline examination. BNP concentrations were determined at baseline examination and at 2 and 6 months later. Renal function was assessed via the Cockroft-Gault formula. Nutritional status was assessed using the geriatric nutritional risk index (GNRI). Final reference diagnosis was established by both cardiologist and geriatrician. The diagnostic value of BNP was assessed by area under the ROC curve. The average age of the 64 patients was 84.3±7.4 years. The final diagnosis was HF in 26 patients (41%). A BNPvalue of 90% (accuracy 80%) for excluding the diagnosis of HF. BNP values were predictive of cardiovascular events over a 2-month timeframe in patients with HF and over a 6-month timeframe in the global population. BNP values were not predictive of mortality in patients with or without HF. BNP testing should help to differentiate pulmonary from cardiac etiologies of dyspnea, but a specific cut-off point has to be used in geriatric settings, mainly for patients presenting nutritional and renal dysfunctions.

  18. Pulmoner emboli tanısında D-dimer düzeyleri ile ventilasyon/perfüzyon sintigrafisindeki bulgular arasındaki ilişki

    Directory of Open Access Journals (Sweden)

    Zekiye Hasbek

    2014-09-01

    Full Text Available Amaç. Pulmoner emboli (PE ölüm riskinin yüksek olması ve PE kuşkusu ile başlanan antikoagülan tedavinin yüksek kanama riski taşıması, tanının en kısa sürede doğrulanmasını ya da dışlanmasını gerektiren kardiovasküler hastalıktır. Ventilasyon/perfüzyon (V/P sintigrafisi PE şüphesinde yaygın kullanılan testlerden biridir. D-dimer fibrin yıkımının bir ürünüdür. Ancak akut trombozlar için spesifik değildir. Bu çalışmada amacımız, D-dimer düzeyleri ile ventilasyon/perfüzyon sintigrafisindeki perfüzyon defekt sayısı arasındaki ilişkiyi araştırmaktı. Yöntem. Çalışmamızda, PE ön tanısı ile takip edilen 100 olgunun D-dimer düzeyleri ile V/P sintigrafileri arasındaki ilişki araştırıldı. Hastaların sintigrafik bulguları perfüzyon defekti açısından; “perfüzyon defekti yok”, “subsegmenter tutulum”, “bir segment tutulum”, “iki segment tutulum”, “üç segment tutulum” ve “üçten fazla segment tutulum” şeklinde altı gruba; pulmoner emboli olasılığı açısından ise “pulmoner emboli yok”, “düşük olasılıklı”, “orta olasılıklı” ve “yüksek olasılıklı” şeklinde dört gruba ayrıldı. D-dimer düzeyi referans aralığı 0,00-0,50 µg/mL idi. Bulgular. Çalışmaya alınan 100 hastanın 52’si erkek 48’i kadındı. Pulmoner emboli olmayan 65 hastada D-dimer: 4,39 ± 9 µg/mL; düşük olasılıklı 20 hastada D-dimer: 4,57 ± 4 µg/mL; orta olasılıklı olan 9 hastada D-dimer: 6,38 ± 6 µg/mL; yüksek olasılıklı olan 6 hastada D-dimer: 8.0±8µg/mL olarak bulundu (p>0,05. Perfüzyon defekti izlenen segment sayısına göre; perfüzyon defekti olmayan 22 hastada D-dimer: 3,01 ± 4 µg/mL; subsegmenter defekti olan 8 hastada D-dimer: 3,62 ± 3 µg/mL; 1 segment defekti olan 14 hastada D-dimer: 10,7 ± 18 µg/mL; 2 segment defekti olan 11 hastada D-dimer: 3,16 ± 2 µg/mL; 3 segment defekti olan 10 hastada D-dimer: 3,86 ± 3

  19. COPD患者D-二聚体和纤维蛋白原检测的临床价值%The clinical value of D-Dimer and plasma fibrinogen in patients with chronic obstructive pulmonary disease

    Institute of Scientific and Technical Information of China (English)

    周洋; 龚建化; 黄河; 张家洪

    2012-01-01

    目的 探讨COPD患者血浆D-二聚体和纤维蛋白原检测的临床意义.方法 分别检测122例按病情严重程度分期、分度的COPD患者和30例健康对照组血浆D-二聚体和纤维蛋白原含量,分析比较各组间血浆D-二聚体和纤维蛋白原含量的差异.结果 COPD患者血浆D-二聚体和纤维蛋白原含量明显高于健康对照组(P<0.05),且急性加重期明显高于稳定期(P<0.05).在75例急性加重期COPD患者中,轻、中、重、极重度患者其血浆D-二聚体和纤维蛋白原含量间相互比较(P<0.05).结论 COPD患者存在血液高凝状态,且随着病情的加重而加重,对其监测和预防性使用抗凝、溶栓剂是非常必要的.%Objective To investigate the clinical significance of the level of plasma D-dimer and plasma fibrinogen in patients with COPD. Methods According to severity stage, the plasma D-dimer and plasma fibrinogen level were measured in 122 patients with COPD. 30 healthy subjects were included as controls. All the measures of D-dimer and plasma fibrinogen were compared between the groups. Results The levels of D-dimer and fibrinogen in 122 patients were significantly higher than those in the control group (P < 0.05 ) , and the levels of D-dimer and fibrinogen in the acute exacerbation were significantly higher than those in the stable. In 75 patients with acute exacerbation of COPD patients, the levels of plasma D-dimer and fibrinogen in mild, moderate, severe and critical patients were compared, and the group differences were statistically significant (P < 0. 05 ). Conclusion The patients with COPD are in a state of hy-percoagulability, and the levels of plasma D-dimer and fibrinogen are related to the severity of COPD attack. To monitor and preventively use anticoagulant, the use of thrombolytic agent is necessary.

  20. Relativity analysis of serum D-dimer content to stage and onset age of stroke%血浆D-二聚体含量与脑卒中病期、发病年龄的相关性研究

    Institute of Scientific and Technical Information of China (English)

    李东燕

    2002-01-01

    Objective To assess its significance to diagnosis, treating and prognosis of ischemic cerebrovascular disease by measuring plasma D dimer of 100 patients. Method By enzyme linked immunosorbent assay and double antibody sandwich assay, making color matching under 492 nm wavelength and to gain the plasma D dimer content value according to the standard curve.Result Serum D dimer content of acute cerebral infarction patients was significantly increase, which reflect increase of fibrinolysis activity and increase of thrombin production.It is a valuable index to hypercoagulation state and thrombosis. The Older the age, the higher the plasma D dimer content. Conclusion It is suggested that there was apparent change of D dimer in course of ischemic cerebrovascular diseases and in patients beyond 60, which engender hypercoagulation state leading to disease.

  1. D-二聚体水平在系统性红斑狼疮的临床意义%The clinical significance of D-dimer in systemic lupus erythematosus

    Institute of Scientific and Technical Information of China (English)

    李春; 穆荣; 任立敏; 范文强; 任长吉; 栗占国

    2010-01-01

    目的 了解系统性红斑狼疮(SLE)患者D-二聚体水平及其临床意义.方法 选北京大学人民医院住院的261例SLE患者,收集临床及实验室资料,分析D-二聚体水平及其与SLE患者临床特征及实验室检查指标的相关性.结果 (1)除外合并肾功能不全、严重感染、弥漫性血管内凝血(DIC)、肝功能异常、妊娠及外伤等可能影响D-二聚体水平的因素,261例SLE患者中入选205例,其中D-二聚体水平升高者达69.3%(142/205).(2)D-二聚体水平升高与SLE疾病活动指数(SLEDAI)评分呈正相关(r=0.598,P=0.000),并与抗双链DNA抗体阳性、C反应蛋白(GRP)升高、补体C3、补体C4降低等有一定相关性.(3)D-二聚体水平升高者脏器损伤比例增加,狼疮性肾炎(58.5%比38.1%)、神经精神性狼疮的发生率(18.3%比4.8%)明显高于D-二聚体水平正常者.(4)伴有血栓形成的SLE患者均有D-二聚体水平升高,但不合并血栓形成者D-二聚体水平升高或正常.结论 D-二聚体水平升高可见于SLE活动期及有重要脏器损伤者,并不必然提示血栓形成.但是,伴发血栓形成的SLE患者均有D-二聚体升高.%Objective To investigate the clinical significance of D-dimer in systemic lupus erythematosus (SLE). Methods The study group comprised 261 SLE patients who were admitted in ward from 2005 to 2008 in Peking University People's Hospital Collect the clinical data to investigate the clinical significance of D-dimer. Results ( 1 ) The D-dimer levels of 56 patients were increased due to coexist reduced renal function, infections, disseminated intravascular coagulation ( DIC), liver disorders, pregnancy and injury. With the exception of above patients, 142 ( 69. 3 ) patients were increased in total 205 patients. (2)The level of D-dimer was positively correlated with SLE disease activity index( SLEDAI ) score ( r =0. 598,P =0. 000), and was associated with anti-dsDNA antibody, ESR, C-reactive protein(CRP) and complement C3

  2. On the comparison of the polarisation behaviour of exchange-biased AF/F NiMn/Fe 37Co 48Hf 15 bi-layer and multi-layer films with increased ferromagnetic cut-off frequencies

    Science.gov (United States)

    Seemann, K.; Leiste, H.; Krüger, K.

    2012-03-01

    Antiferromagnetic/ferromagnetic (AF/F) NiMn/Fe37Co48Hf15 films were investigated with respect to their exchange bias, in-plane unidirectional anisotropy, polarisation and high frequency behaviour. After deposition, carried out by r.f. magnetron sputtering, the films were post-annealed for 4 h at 300 °C in a static magnetic field, in order to induce exchange-bias, which results in a unidirectional anisotropy. Dependent on the presence of a bi-layer or multi-layer sandwich structure the films show a different exchange-bias field-ferromagnetic inter-layer thickness behaviour with exchange-bias fields μ0*Heb between 2 and 10 mT. The in-plane uniaxial (single film) or unidirectional anisotropy fields μ0*HUF were between 4 and 18 mT. This results in a significant increase of the cut-off frequency in the GHz range in comparison to a single Fe37Co48Hf15 film, which is shown by frequency-dependent permeability plots. High damping in the imaginary part of the permeability, i.e., high resonance line broadening could be observed for films with high coercivity μ0*Hc of around 7 mT in the easy axis of magnetisation.

  3. Optimal cut-off point of waist-to-height ratio for predicting metabolic syndrome%腰围身高比预测代谢综合征的切点研究

    Institute of Scientific and Technical Information of China (English)

    蒋建家; 张雅萍; 林振忠; 牟伦盼; 孙炳庆; 苏劲波

    2015-01-01

    Objective To investigate the relationship between waist-to-height ratio and metabolic syndrome,in order to identify the optimal cut-off point of waist-to-height ratio for predicting metabolic syndrome.Methods In this cross-sectional study,we recruited 343 people who received physical examination in First Hospital of Quanzhou between January 2012 and June 2014,and collected the information of their waist circumference,height,weight,blood pressure,laboratory test results (including fasting blood glucose,2-hour glucose after oral glucose tolerance test,triglyceride,high-density lipoprotein cholesterol) and visceral fat area assessed by computed tomography.Then a receiver operating characteristic (ROC) curve analysis was used to estimate the optimal cut-off points of waist-to-height ratio for the prediction of metabolic syndrome.Results Among the 343 people,there were 195 metabolic syndrome patients,the prevalence rate was 56.8%,which was 70.2% in men (127/181) and 42.0% in women (68/162).In ROC curve analysis,the area under the curve of waist-to-height ratio for the prediction of metabolic syndrome was 0.664 for men,and 0.673 for women.The optimal cut-off point of waist-to-height ratio for predicting metabolic syndrome was 0.543 0 (sensitivity 88.2%,specificity 44.4%) for men,and 0.568 3 (sensitivity 86.8%,specificity 46.8%).Conclusion The optimal cut-off point of waist-to-height ratio for predicting metabolic syndrome in Quanzhou population is 0.543 0 for men and 0.568 3 for women.%目的 研究腰围身高比与代谢综合征的关系,寻找腰围身高比预测代谢综合征的最佳切点.方法 采用横断面调查方法,纳入2012年1月至2014年6月在福建医科大学附属泉州第一医院进行体检的343名人员,体检项目包括腰围、身高、体质量、血压、实验室检查(包括空腹血糖、口服葡萄糖耐量试验2h血糖、三酰甘油、高密度脂蛋白胆固醇)、CT测定腹腔内脂肪面积.通过受试者工

  4. Cutting off Mediation. Agamben as Master Thinker

    Directory of Open Access Journals (Sweden)

    Astrid Deuber-Mankowsky

    2015-02-01

    Full Text Available Agamben’s Homo Sacer turns centrally upon “bare life”. However, the following subjects are not thematized: natality, gender, sexuality, the relation of the sexes, the heterosexual character of the symbolic order and political culture, the interest of women in the reproduction of life. The entire question of sexual difference —like that of the difference between victim and perpetrator, between witnesses and those born afterwards— is banned from Agamben’s horizon. Thus a deep unease remains, which this paper is intended to explore. It will first present the methodological and theoretical inspirations, which Homo Sacer owes to the thought of Carl Schmitt. Secondly it will show that Schmitt’s concepts of nomos and the state of exception cannot provide a suitable basis for rewriting Foucault’s concept of biopolitics.

  5. Analysis of D-dimer level of normal pregnancy and pregnancy hypertension syndrome pregnant woman%正常妊娠与妊娠高血压综合征孕妇D-二聚体水平分析

    Institute of Scientific and Technical Information of China (English)

    李明兰

    2014-01-01

    Objective:To analyze the difference of D-dimer level of normal pregnancy and pregnancy hypertension syndrome pregnant woman,and to explore the influence of hypertension on D-two dimer level of pregnant women.Methods:128 pregnant women were selected from March 2010 to October 2013.According to with hypertension or not,they were divided into the pregnancy induced hypertension syndrome group(60 cases) and the normal pregnancy group(68 cases),at the same time,70 healthy women were selected as the control group.We compared the plasma D-dimer level of the three groups.Results:The D-dimer level of pregnancy induced hypertension group and normal pregnancy group were significantly higher than those of the control group(P<0.05,P<0.01).The D-dimer level of pregnancy induced hypertension group were significantly higher than that of normal pregnancy group(P<0.05);between the different degree pregnancy induced hypertension,the plasma D-dimer level had significant difference(P<0.05).Conclusion:The plasma D-dimer content of normal pregnancy is increased,and the blood is become hypercoagulable state.Patients with hypertensive disorders in pregnancy have the pathological changes of the coagulation system,and the plasma D-dimer level is higher than that of normal pregnancy.We suggest that we should examine the plasma D-dimer level of patients with hypertension of pregnancy,and understand the existence of thrombotic diseases,to protect the health of mother and infant.%目的:分析正常妊娠与妊娠高血压综合征孕妇血浆D-二聚体水平差异,探讨高血压对妊娠期妇女D-二聚体水平的影响。方法:2010年3月-2013年10月收治妊娠期孕妇128例,按照是否合并高血压分为妊娠期高血压综合征组(60例)和正常妊娠组(68例),另选择同期健康女性70例作为对照组。对比3组血浆D-二聚体水平。结果:妊娠高血压组、正常妊娠组D-二聚体水平显著高于对照组(P<0.05,P<0.01)。妊娠高血压

  6. 皮肤点刺试验阳性界值与sIgE对间歇性变应性鼻炎的诊断价值%Diagnostic value of positive cut-off values in skin prick test and sIgE for intermittent allergic rhinitis

    Institute of Scientific and Technical Information of China (English)

    石晓; 魏利召; 王东; 刘一

    2014-01-01

    Objective To explore the influence of different positive cut-off values of skin prick test(SPT) in the evaluation of serum specific IgE(sIgE) in the diagnosis of allergic rhinitis(AR) soldiers in Inner Mongolia,and to evaluate the diagnostic consistency between SPT and serum sIgE.Methods66 soldiers in a station of Inner Mongolia who had positive clinical symptoms and signs of AR were accepted SPT with 23 kinds of inhalant allergens, then 31 intermittent AR soldiers were selected, who had no less than 4 positive SPT and higher level of positve results. According to SPT, aforementioned 31 soldiers underwent detection of Artemisia vulgaris, Artemisia absinthium, Ambrosia trifida, Humulus scandens, Ulmus americana, Salix caprea, Betula verrucosa and taraxaci sIgE that was performed, using UniCAP100 system. The reference standard of AR was established according to the clinical symptoms, signs and positive SPT. The influence of diagnostic value of sIgE was evaluated based on“+”and“++”positive cut-off value of SPT, respectively. The diagnostic indexes includes sensitivity, specificity, positive predictive value, negative predictive value and concordance rate. And the diagnostic consistency between SPT and serum sIgE was also evaluated.Results ①Artemisia pollen was the major allergen among intermittent AR soldiers at this station and its SPT positive rate was more than 60%, followed by Sunflower, Humulus scandens, ragweed, Betula alba, Ulmus americana and Salix caprea in turns, with the SPT positive rate being more than 30%.②Based on“+” positive cut-off value of SPT, the sensitivity of serum sIgE ranged from 0.500(Humulus scandens) to 0.982(Artemisia), the specificity ranged from 0.500(ragweed, Ulmus americana, Betula verrucosa) to 1.000(Artemisia), and the concordance rate ranged from 0.581(Humulus scandens) to 0.984(Artemisia). When adjusting the cut-off value to“++”, the sensitivity of serum sIgE ranged from 0.524(Humulus scandens) to 0.982(Artemisia

  7. ROC curve establish to cut-off value of hematologic indicators for thalassemia screening%ROC曲线确立血液学各指标在地贫筛查中的CUT-OFF值

    Institute of Scientific and Technical Information of China (English)

    张强; 何升; 阙婷; 唐燕青

    2013-01-01

    Objective: Establish to cut - off value of hematologic indicators for thalassemia screening. Methods: Use SYSMEX he- matology analyzer to detect MCV, MCH, RDW - CV, Hb RBC, use HPLC analyzer HBA2. All of examples carry out thalassemia gene test which apply gap - per and RDB principle. Result: MCV MCH are better than other hematologic indicators. In thalassemia screening. MCV is higher than MCH RDW - CV HBA2 showed value for β thalassemia screening. RBC and HB have screening of limited value. Conclusion; Laboratory should establish; to suit cutoff value in order to ruduse missed diagnosis and Diagnostic Errors.%目的 用ROC曲线(受试者工作特征曲线)确立各血液学指标在地贫筛查中的切值.方法 以SYSMEX五分类血细胞分析仪进行全血细胞计数,记录RBC,HB,MCH,MCV,RDW-CV的数值.用伯乐HPLC进行血红蛋白电泳分析记录HBA2值.所有标本进行地中海贫血基因检测.采用gap-pcr及RDB(反向点杂交)原理对筛查结果进行验证.结果 在地贫筛查中MCV和MCH比较有价值,MCV的价值略大于MCH,RDW-CV,和HBA2对β地贫的筛查价值更加的显著,而RBC及HB在地贫筛查中价值不大.结论 为减少漏诊及误诊,实验室应该建立合适的切值

  8. Comparison of VerifyNow-P2Y12 test and Flow Cytometry for monitoring individual platelet response to clopidogrel. What is the cut-off value for identifying patients who are low responders to clopidogrel therapy?

    Directory of Open Access Journals (Sweden)

    Castelli Alfredo

    2009-05-01

    Full Text Available Abstract Background Dual anti-platelet therapy with aspirin and a thienopyridine (DAT is used to prevent stent thrombosis after percutaneous coronary intervention (PCI. Low response to clopidogrel therapy (LR occurs, but laboratory tests have a controversial role in the identification of this condition. Methods We studied LR in patients with stable angina undergoing elective PCI, all on DAT for at least 7 days, by comparing: 1 Flow cytometry (FC to measure platelet membrane expression of P-selectin (CD62P and PAC-1 binding following double stimulation with ADP and collagen type I either in the presence of prostaglandin (PG E1; 2 VerifyNow-P2Y12 test, in which results are reported as absolute P2Y12-Reaction-Units (PRU or % of inhibition (% inhibition. Results Thirty controls and 52 patients were analyzed. The median percentage of platelets exhibiting CD62P expression and PAC-1 binding by FC evaluation after stimulation in the presence of PG E1 was 25.4% (IQR: 21.4–33.1% and 3.5% (1.7–9.4%, respectively. Only 6 patients receiving DAT (11.5% had both values above the 1st quartile of controls, and were defined as LR. Evaluation of the same patients with the VerifyNow-P2Y12 test revealed that the area under the receiver-operating-characteristic (ROC curve was 0.94 (95% CI: 0.84–0.98, p 213 PRU gave the maximum accuracy for the detection of patients defined as having LR by FC. Conclusion In conclusion our findings show that a cut-off value of ≤ 15% inhibition or > 213 PRU in the VerifyNow-P2Y12 test may provide the best accuracy for the identification of patients with LR.

  9. 电励磁同步电动机转矩角截止负反馈闭环控制%Torque-Angle Cut-Off Negative Feedback Closed-Loop Control Strategy of Electrical Excited Synchronous Motor

    Institute of Scientific and Technical Information of China (English)

    谢慕君; 步伟明; 冯敬芳; 王志乾

    2013-01-01

    针对电励磁同步电动机负载变化易失步的问题,通过对转矩角特性分析,提出了一种基于转矩角截止负反馈的控制策略。阐述了利用转矩角控制防止失步的原理,建立了基于同步电动机磁链观测的转矩角数学模型,并设计了转矩角外环、励磁电流内环的双闭环控制系统。仿真结果表明,该控制策略与常规控制相比,适应负载变化的能力显著提高,有效抑制了电机的失步,为电机的稳定控制开辟了新途径。%Aiming at the problem that the electrical synchronous excited motor will be out of step with the load changes, this paper raised a control strategy based on torque-angle cut-off feedback via the analysis of torque-angle characteristics. Discussion was made to the principle using torque-angle control to prevent out-of-step. The mathematical model of torque-angle was constructed based on the flux linkage observation of synchronous motors and the double closed-loop control system for the outer loop adopting torque-angle and the inner loop adopting field current were designed. The simulation results show that compared with conventional control, this control strategy obviously met the requirements of load changes, effectively restraining out-of-step of motors, which opens up a new way for stable control of motors.

  10. ADJUSTMENT FACTORS AND ADJUSTMENT STRUCTURE

    Institute of Scientific and Technical Information of China (English)

    Tao Benzao

    2003-01-01

    In this paper, adjustment factors J and R put forward by professor Zhou Jiangwen are introduced and the nature of the adjustment factors and their role in evaluating adjustment structure is discussed and proved.

  11. Body mass index cut-offs for overweight and obesity in Chinese children and adolescents aged 2-18 years%中国2~18岁儿童青少年超重和肥胖筛查体重指数界值点的研究

    Institute of Scientific and Technical Information of China (English)

    李辉; 宗心南; 季成叶; 米杰

    2010-01-01

    Objective To study the body cut-offs of mass index (BMI) for the purpose of screening overweight and obesity for Chinese children and adolescents aged 2-18 years. Methods Based on the BMI growth reference values for Chinese children aged 0-18, using the common methods to establish the BMI cut-offs for screening overweight and obesity. These methods were having the same empirical percentile or Z scores and the BMI value at 18 years consistent with adults.Three sets of BMI cut-offs, including (BMI24, BMI28) , (P85, P95) and (Z1, Z2) , were initially identified. Differences were compared on different cut-off points and prevalence rates of overweight and obesity with different BMI reference, different values and "prevalence" of overweight and obesity based on "2004 Beijing Child and Adolescent Metabolic Syndrome Study ". Cut-offs standards which recommended by the Chinese Working Group on Obesity for Children (WGOC) and by the International Obesity Task Force (IOTF) were also used. Finally the appropriate cut-offs were defined. Results Three sets of BMI cut-offs for screening overweight and obesity for Chinese children and adolescents aged 2-18 years were obtained according to the above mentioned methods for selection. The prevalence rates of overweight and obesity defined by those cut-offs appeared not to be significantly different. Compared with the WGOC, the BMI cut-off points for screening overweight and obesity for both boys and girls from our study were very close to the WGOC', but cut-off points for screening overweight for girls aged 8.5-15.5 y was 0.3-1.0 kg/m2 lower than the WGOC'. Going through the database on screening of "2004 Beijing Children's Metabolic Syndrome Survey ", the prevalence of overweight for girls was about 3.4% higher than using the cut-offs of WGOC. Conclusion Results from this study suggested that the BMI cut-offs passed through the cut-off point of BMI24 and BMI28 at 18 years was appropriate for screening overweight and obesity in

  12. GDM患者D-二聚体、CRP和尿酸检测的临床意义%Clinical significance of D-Dimer, c-reactive protein and uric acid test in patients with gestational diabetes mellitus

    Institute of Scientific and Technical Information of China (English)

    聂艳华; 赵丽萍

    2014-01-01

    目的:探讨妊娠期糖尿病( GDM)患者血浆D-二聚体、C反应蛋白( CRP)和尿酸检测的临床意义。方法检测108例GDM孕妇血浆D-二聚体、CRP和尿酸的水平,同时选择108例健康孕妇作为对照,分析血浆D-二聚体、CRP和尿酸在GDM诊断中的临床意义。结果 GDM患者血浆D-二聚体、CRP和尿酸与健康孕妇相应参数比较,差异均有统计学意义( t值分别为2.33、8.61、7.73,均P<0.05)。结论 D-二聚体、CRP和尿酸的测定在GDM的诊断和预后判断中具有重要临床价值。%Objective To explore the clinical significance of D-dimer, c-reactive protein (CRP) and uric acid test in patients with gestational diabetes mellitus ( GDM) .Methods Plasma D-dimer, CRP and uric acid level of 108 cases of GDM were tested , and 108 healthy pregnant women were selected as controls .The clinical significance of D-dimer, CRP and uric acid level in the diagnosis of GDM was analyzed.Results Plasma D-dimer, CRP and uric acid level in patients with GDM were significantly different from those of the controls (t value was 2.33, 8.61 and 7.73, respectively, all P<0.05).Conclusion The determination of D-dimer, CRP and uric acid has important clinical value in the diagnosis and prognosis judgment of GDM .

  13. D-二聚体定量检测在毛细支气管炎中的应用%Application of quantitative detection of D-dimer in bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    陈学高

    2015-01-01

    Objective To investigate the clinical significance of D-dimer changes in children with bronchiol-itis. Methods 61 children with bronchiolitis were selected and divided into the normal group and the severe group based on their situation, and 11 healthy children were taken as the control group. The levels of D-dimer were detec-ted. Results The level of D-dimer was significantly higher in the study group than in the control group, and it was higher in the severe group than in the normal group (P<0. 01). After the treatment, the level of D-dimer decreased significantly in the severe group (P<0. 01). Conclusion The level of plasma D-dimer can be used to judge the se-verity of bronchiolitis.%目的:探讨毛细支气管炎患儿D-二聚体( D-D)水平变化及临床意义。方法随机选取61例毛细支气管炎住院患儿,根据病情程度分为普通组与重症组,同时选取11例同龄健康婴儿作为正常对照组。检测其血浆D-二聚体水平。结果毛细支气管炎患儿组血浆D-二聚体水平显著高于对照组,重症毛细支气管炎患儿血浆D-二聚体水平显著高于普通患儿组,差异具有统计学意义(P<0.01)。而且重症毛细支气管炎患儿治疗前后血浆D-二聚体水平差异显著,具有统计学意义( P<0.01)。结论血浆D-二聚体水平检测可用于毛细支气管炎病情严重程度的判定。

  14. 检测D-二聚体对快速筛查主动脉夹层的临床意义%Clinical significance of D-dimer in rapid screening for acute aortic dissection

    Institute of Scientific and Technical Information of China (English)

    杨军; 王烁; 李春盛

    2010-01-01

    目的 探讨D-二聚体及其他易获得的实验室指标对筛查急性主动脉夹层的意义.方法 回顾性分析明确诊断为急性主动脉夹层及急性冠状动脉综合征患者的外周血白细胞、C反应蛋白、肌钙蛋白-Ⅰ以及D-二聚体的检测结果,结合临床症状,以logistic回归分析方法分析各项指标对急性主动脉夹层的临床诊断意义,并以受试者工作特征曲线评价诊断结果.结果 Ⅰ型急性主动脉夹层患者D-二聚体明显升高,与Ⅱ型、Ⅲ型患者比较差异有统计学意义(P值分别为0.011和0.002).D-二聚体、白细胞及C反应蛋白是Ⅰ型急性主动脉夹层的独立危险因素.可以建立logistic回归方程,以D-二聚体对方程式结果影响最大,受试者工作特征曲线亦支持此分析结果.结论 D-二聚体影响对Ⅰ型急性主动脉夹层有诊断意义,结合外周血白细胞和C反应蛋白等指标可以对急性主动脉夹层进行快速筛查.%Objective To investigate clinical significance of D-dimer and other easily-obtained laboratory parameters in rapid screening for acute aortic dissection ( AAD). Methods Data of general health, clinical symptoms, white blood cell (WBC) count, serum levels of C-reactive protein (CRP),cardiac troponin Ⅰ (cTn Ⅰ ) and D-dimer in patients with confirmed AAD and acute coronary syndrome (ACS) were retrospectively analyzed. Significance of varied parameters in clinical diagnosis for AAD was evaluated by logistic regression model and their diagnostic values were evaluated by receiver operating characteristics (ROC) curve. Results Serum level of D-dimer increased significantly in patients with type Ⅰ AAD, as compared with that in those with type Ⅱ and type Ⅲ (P = 0. 111 and 0. 002, respectively). D-dimer, WBC and CRP all were independent risk factors for type Ⅰ AAD by logistic regression model fitted,with the largest effect of D-dimer. Analysis by ROC curve with sensitivities and specificities of

  15. 血浆D-二聚体测定在深静脉血栓形成中的意义%Measuring of D-dimer in patients with deep venous thrombosis

    Institute of Scientific and Technical Information of China (English)

    徐颖; 钱申贤

    2013-01-01

    目的:探讨血浆D-二聚体测定对深静脉血栓形成(DVT)诊断和疗效评估的意义及DVT患者临床危险因素。方法回顾性分析435例DVT患者的血浆D-二聚体水平,同时在体检人群中随机选择150例作为对照组,比较分析DVT患者中135例初诊时的危险因素。进一步监测其中的33例DVT患者治疗后1~3d、7~10d、15d的血浆D-二聚体变化情况。结果 DVT患者血浆D-二聚体水平与对照组相比有统计学差异(P=0.000),抗凝治疗的有效率为78.8%。治疗有效组DVT患者的血浆D-二聚体下降程度与无效组相比有统计学差异(P=0.005)。年龄<40岁的DVT患者中手术和外伤是主要危险因素,而年龄≥40岁患者中肿瘤、内科疾病、中心静脉置管及长期卧床是其主要危险因素。结论血浆D-二聚体是DVT诊断及疗效评估的重要指标,DVT危险因素是其一级预防的依据。%Objective To investigate plasma D- dimer levels in patients with deep venous thrombosis (DVT). Methods Plasma D- dimer levels were measured in 435 patients with DVT, and 150 healthy subjects (controls). The clinical data and plas-ma D- dimer levels were retrospectively analyzed in 135 DVT patients and the D- dimer levels were monitored in 33 DVT patients during the anticoagulation therapy at different time points (at 1~3d, 7~10d and 15d). Results Compared to healthy subjects, plasma D- dimer levels in DVT patients were significantly increased (P=0.000). The overal effective rate of treatment was 78.8%, D- dimer levels in effective patientws was significantly decreased after treatment (P=0.005). For patients aged<40, surgery and trauma were major risk factors of DVT;for those aged≥40, medical diseases, cancer, placement of central venous catheter and long- term bed rest were major risk factors. Conclusion Measurement of plasma D- dimer levels is of value in diagnosis and monotoring of therapeutic effect for patients with deep vein

  16. Relationship between disseminated intravascular coagu-lation and levels of plasma thrombinogen segment 1+2,D-dimer, and thrombomodulin in patients with multiple injuries

    Institute of Scientific and Technical Information of China (English)

    ZHU Yu-jun; HUANG Xian-kai

    2009-01-01

    Objective: To explore the relationship between dis-seminated intravascular coagulation (DIC) and levels of plasma thrombinogen segment 1+2 (F1+2), D-dimer (D-D), and thrombomodulin (TM) in patients with severe multiple injuries.Methods: In this study, 66 patients (49 males and 17 females, aged 15-74 years, mean=38.4 years) with multiple injuries, who were admitted to our hospital within 24 hours after injury with no personal or family history of hematopathy or coagulopathy, were divided into a minor injury group (ISS≥16, n=45) according to the injury severity. The patients in the major injury group were divided into a subgroup complicated with DIC (DIC subgroup, n=12) and a subgroup compli-cated with no DIC (non-DIC subgroup, n=33). Ten healthy people (7 males and 3 females, aged 22-61 years, mean=36.5 years±9.0 years), who received somatoscopy and diagnosed as healthy, served as the control group. Venous blood samples were collected once in the control group and 1, 3 and 7 days after trauma in the injury groups. The F1+2 and TM concentrations were determined by enzyme linked immunosorbent assay (ELISA), and D-D concentrations were measured by automated latex enhanced immunoassay. Results: F1+2, D-D and TM levels were higher in the minor and major injury groups than in the control group.They were markedly higher in the major injury group than in the minor injury group. In the non-DIC subgroup, F1+2 levels declined gradually while D-D and TM levels declined continuously. In the DIC subgroup, F1+2 and D-D levels remained elevated while TM levels exhibited an early rise and subsequent decrease. Plasma F1+2, D-D and TM levels were higher in the DIC patients than in the non-DIC patients. Injury-induced increases in F1+2, D-D and TM plasma lev-els had significant positive correlation with each other at each time point.Conclusions: Besides being related to trauma severity, F1+2, D-D and TM levels correlate closely with the occur-rence of posttraumatic DIC. Therefore

  17. Role of signal-to-cut-off ratios of anti-hepatitis C virus antibody by enzyme immunoassays along with ID-NAT for screening of whole blood donors in India

    Directory of Open Access Journals (Sweden)

    Satyam Arora

    2016-01-01

    Full Text Available Background: The use of elevated signal-to-cut off ratios (S/CO as an alternate to further supplemental testing (i.e., RIBA has been included in the guidelines provided by the Centres for Disease Control and Prevention for HCV diagnostic purposes since 2003. With availability of screening by NAT and non availability of RIBA, further confirmation of HCV infection has been possible at the molecular level (RNA. Aims: To study the role of S/CO ratios of anti hepatitis C virus antibody detection by enzyme immunoassays (EIA along with ID-NAT for screening of whole blood donors. Methods: In this study we reviewed the donor screening status for anti HCV from January 2013 to May 2014. All the donations were screened for anti HCV with fourth generation ELISA (BioRad Monolisa Ag-Ab Ultra as well as with ID NAT (Procleix Ultrio. The S/CO ratio of all the anti-HCV reactive samples were analysed for their presence of HCV RNA. Results: On screening 21,115 donors for HCV, 83 donors (0.39% were found reactive on pilot tube and repeat plasma bag testing (S/Co ratio ≥1 by ELISA. 41 donors were HCV RNA reactive with ID-NAT. 4 samples out of 41 were NAT yields and 37 were concordant reactive with ELISA. The S/Co ratio of anti-HCV reactive samples ranged from 0.9-11.1 [mean = 5.1; SD ΁ 2.9] whereas S/Co ratio of anti HCV and NAT reactive samples (concordant positives ranged from 4.1-11.1 [mean 7.3]. In our analysis we found that S/CO ratio of 4 showed positive predictive value (PPV and sensitivity of 100%. Summary/Conclusions: Our study showed that S/CO of 4 for anti HCV on ELISA would have maximum positive predictive value of having donor with HCV RNA. S/CO ratio of 4 is very close to 3.8 which was the CDC guideline. The presence of anti-HCV does not distinguish between current or past infections but a confirmed anti-HCV-positive result indicates the need for counseling and medical evaluation for HCV infection.

  18. Pontos de corte para a aptidão cardiorrespiratória e a triagem de fatores de risco para doenças cardiovasculares na infância Cardiorespiratory fitness cut offs points and cardiovascular risk factors screening at infancy

    Directory of Open Access Journals (Sweden)

    Gabriel Gustavo Bergmann

    2010-10-01

    Full Text Available O principal objetivo deste estudo foi analisar a validade e propor novos pontos de corte para aptidão cardiorrespiratória de escolares de sete a 12 anos de idade. A amostra foi constituída por 1.413 escolares. A aptidão cardiorrespiratória foi medida através do teste de corrida/caminhada de nove minutos. O colesterol total e as pressões arterial sistólica e diastólica foram medidas e através delas foram criadas referências de fatores de risco para doenças cardiovasculares. Através da curva receiver operating characteristic entre a aptidão cardiorrespiratória e as referências de fatores de risco para doenças cardiovasculares foram identificados os valores dos pontos de corte. Adicionalmente foi utilizada a análise bivariada seguida do cálculo de razão de chances (odds ratio-OR para identificar quanto os indivíduos que não atenderam os pontos de corte propostos tinham a mais de chance de apresentar fatores de risco para doenças cardiovasculares. Os resultados indicaram que, dentre as propostas analisadas, a que foi sugerida neste estudo apresentou melhores ajustamentos entre sensibilidade e especificidade. Os resultados da análise bivariada mostraram que indivíduos que não atenderam os pontos de corte propostos têm maiores chances de apresentarem fatores de risco para doenças cardiovasculares.The main objective of the study was to analyze and propose news cardiorespiratory fitness cut offs points for 7 to 12-year old school students. The sample was composed of 1,413 students. Cardiorespiratory fitness was measured by the 9-minutes walking/running test. Total cholesterol and systolic and diastolic blood pressure were measured and with their results cardiovascular risk factors reference were designed. The Receiver Operating Characteristic curve between cardiorespiratory fitness and cardiovascular risk factors reference identified the cut offs point values. The bivariate analysis and odds ratio (OR calculation was used to

  19. Integration Technology of Combining Binary-layer Foundation Excavation Dewatering with Suspended Cut-off Wall and Recharge%二元地基基坑降水结合悬挂式防渗墙及回灌一体化技术

    Institute of Scientific and Technical Information of China (English)

    王恒; 李守德; 王由国; 柯倩雯; 张灿虹

    2015-01-01

    In this paper,a generalized model of the typical cross-section is used to study the consequence of excavation dewatering with suspended cut-off wall and recharge well which have some effects on water head and ground subsidence which is outside of excavation. The comparisons of the condition of excavation direct precipitation , the condition of cut-off wall excavation precipitation and the condition of cut-off wall and recharge well excavation dewatering are analyzed. The result shows that suspended cut-off wall and recharge well can significantly enhance the water head and effectively reduce the settlement in the outside of the excavation,reduce the unit sedimentation of soft soil,have little effect on the unit sedimentation of silt and sand layers. Meanwhile,the comparisons of the tilt ratio of three conditions indicate the distance away from cut-off wall and recharge well closer ,the smaller the differential settlement.%通过构造基坑降水三维概化模型,利用有限元软件FLAC3D分析悬挂式防渗墙和回灌对基坑坑外的水头和地面沉降影响,主要将基坑直接降水工况、设置防渗墙的基坑降水工况和设置防渗墙及回灌井的基坑降水工况进行对比分析。分析结果表明防渗墙和回灌井,可明显提升坑外水头,有效降低了坑外沉降,减小软土层的单位沉降值,对粉砂层和细砂层的单位沉降值影响很小。同时,对比三种工况下的倾斜比,说明了距离防渗墙与回灌井越近,不均匀沉降越小。

  20. Convexity Adjustments

    DEFF Research Database (Denmark)

    M. Gaspar, Raquel; Murgoci, Agatha

    2010-01-01

    A convexity adjustment (or convexity correction) in fixed income markets arises when one uses prices of standard (plain vanilla) products plus an adjustment to price nonstandard products. We explain the basic and appealing idea behind the use of convexity adjustments and focus on the situations...

  1. D-二聚体检测在2型糖尿病并发症诊断中的应用%D-dimer in the detection of complications of diabetes diagnosis

    Institute of Scientific and Technical Information of China (English)

    彭易清

    2009-01-01

    目的 研究血浆D-二聚体在2型糖尿病相关并发症诊断的价值.方法 将74例糖尿病患者分为无并发症组(45例)、并发症组(29例),同时设健康对照组(46例),采用ELISA法分别测定各组血浆D-二聚体水平并进行比较.结果 糖尿病并发症组D-二聚体水平明显高于健康对照组(P0.05).结论 检测糖尿病D-二聚体是糖尿病并发血管病变的诊断指标之一.严格控制血糖、监测D-二聚体对防治糖尿病并发症有一定意义.%Objective To study the clinical significance of blood plasma D-dimer in diabetes mel-litus patients. Methods Divides into 74 example diabetes group without the complication group (45 examples), the complication group (29examples), and carries on the comparison with the control group 46 examples, uses the ELISA method to determine each group of blood plasma D-direct level separate-ly. Results Diabetes complication group D-dimer level is higher than the control group obviously(P0.05). Conclusion The examination diabetes D-direct is one of diabetes con-current blood vessel pathological change's diagnosis targets. The strict control blood sugar, monitors the D-dimer to prevent and control diabetes complication to have certain significance.

  2. Sensitivität des D-Dimers zum Ausschluß venöser thromboembolischer Erkrankungen im klinischen Alltag

    Directory of Open Access Journals (Sweden)

    Lohr G

    2007-01-01

    (falsch negative Rate 1,3 %. Die Sensitivität betrug hier 98,7 %. In unserer Arbeit zeigen sich im Vergleich D-Dimere alleine und Kombination D-Dimertest/KW mit verschiedenen Scoresystemen zwar nicht signifikante Unterschiede in den falsch negativen Ergebnissen, bei allerdings geringer Fallzahl. Die falsch negative Rate von 3,8 % bei alleiniger D-Dimertestung ist bei diesen potentiell tödlichen Erkrankungen hoch. Die Sensitivität und die Sicherheit der Ausschlußdiagnostik kann durch den Einsatz von Scoresystemen in Kombination mit D-Dimertests, die nicht invasiv sind, erhöht werden, und somit eine einfache, leicht durchzuführende und optimale Ergänzung darstellen.

  3. 同型半胱氨酸与D-二聚体检测在妊娠期高血压诊断中的应用%Application of homocysteine and the D-dimer detection in pregnancy induced hypertension

    Institute of Scientific and Technical Information of China (English)

    王海鲜

    2014-01-01

    目的:探讨妊娠期高血压患者检测同型半胱氨酸、血浆D-二聚体的临床意义。方法:检测83例妊娠期高血压患者以及80例血压正常的孕妇的同型半胱氨酸、血浆D-二聚体水平,同时选择85例非妊娠妇女作为对照。结果:妊娠期高血压患者同型半胱氨酸、D-二聚体水平与健康孕妇和非妊娠妇女相比较,差异均有统计学意义(P<0.01);健康孕妇和非妊娠对照组的D-二聚体水平相比较,差异有统计学意义(P<0.01),而同型半胱氨酸水平差异无统计学意义(P>0.05)。结论:同型半胱氨酸、D-二聚体测定在妊娠期高血压的早期诊断和预后判定中具有重要诊断价值。%Objective to study the patients with gestational hypertension homocysteine and the clinical significance of plasma D -dimer.Methods to test 83 cases of gestational hypertension patients,80 cases of pregnant women with normal blood pressure homocys-teine,plasma D -dimer level,at the same time,choose 85 cases of without pregnant women as control .results the patients with gestational hypertension homocysteine,D -dimer level compared with healthy pregnant women and without pregnant women,the difference had statistical significance (P0. 01)conclusion ho-mocysteine,determination of D -dimer in gestational hypertension has important value in early diagnosis and prognosis judgement.

  4. 急性脑梗死患者血浆D-二聚体水平变化%The significance of blood plasma D-Dimer level in diagnosing and treating the acute cerebral infarction patients in the community hospital

    Institute of Scientific and Technical Information of China (English)

    张惠光

    2009-01-01

    目的 观察急性脑梗死患者血浆D-二聚体水平的变化及临床意义.方法 对71例急性脑梗死患者急性期、恢复期和64例健康体检者采用双抗体夹心法检测血浆D-二聚体水平.结果 急性脑梗死患者急性期血浆D-二聚体水平:72 h(1.54±0.91)mg/L、第7天(1.32±0.86)mg/L,较恢复期第15天(0.49±0.31)mg/L、第30天(0.32±0.14)me/L和健康体检者(0.31±0.81)mg/L明显增高(t=2.576、t=2.807,P<0.01).结论 检测血浆D-二聚体可作为急性期脑梗死病情判定及疗效观察的有效指标.%Objective To throagh observing the change of plasma D-Dimer level in the acute cerebral infarction patients to provide the experimental foundation for further research of pathology,physiology pathological process judgment and observation of curative effect.Methods To measure the plasma D-Dimer level by ELISA in 71 cases of acute wrebral infarction patients and 64 healthy controls.Results The plasma D-Dimer level in the acute cerebral infarction patients in acute period was 72h(1.54 ±0.91)mg/L、7d(1.32 ±0.86)mg/L significantly higher than 15d (0.49±0.31)mg/L30d(0.32±0.14)mg/L at resume period patients and(0.31 ±0.81)mg/L at normal controls and dropped in resume period(t =2.576,t =2.807,P<0.01).They had significant difference.Conclusion The results indicate that acute cerebral infarction is in the manifestation of hyper coagulation,plasma D-Dimer measuring was valuable for pathological process judgment and observation of curative effect of acute cerebral infarction.

  5. Association of CRP and D-Dimer with secondary pulmonary hypertension in patients with AECOPD%CRP及D-Dimer在慢性阻塞性肺疾病急性加重期继发肺动脉高压中的相关性

    Institute of Scientific and Technical Information of China (English)

    金丛; 黄相增

    2014-01-01

    Objective To explore the clinical significance of C-reaction protein ( CRP ) and D-Dimer levels in patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD ) complicated by pulmonary hypertension (PH) and their association with HP. Methods Arterial blood gas and levels of CRP and D-Dimer were detected in 150 patients with AECOPD. Results Levels of CRP, D-Dimer, and PaCO2 were higher but PO2 level was lower in patients with moderate to severe PH than those with mild PH and the control subjects. Levels of CRP and D-Dimer were higher in patients with mild PH than the control subjects. Levels of CRP, D-Dimer, and PCO2 levels had a linear relationship with PASP, while PO2 was negatively correlated with PASP. Levels of CRP and D-Dimer were positively related with PCO2, while were negatively correlated with PO2. Conclusions Levels of CRP and D-Dimer can be used as an indicator for estimating the severity of pulmonary hypertension in patients with AECOPD.%目的:探讨C反应蛋白(CRP)及D-二聚体(D-Dimer)在慢性阻塞性肺疾病急性加重期(AECOPD)合并肺动脉高压( PH )患者中的临床意义及相关性。方法:150例AECOPD患者进行CRP、D-Dimer及动脉血气检测。结果:AECOPD合并中重度PH组患者CRP、D-Dimer、PaCO2水平高于轻度PH组及对照组,(P<0.05),而PaO2水平低于轻度PH组及对照组(P<0.05)。AECOPD合并轻度PH组患者CRP、D-Dimer水平高于对照组(P<0.05)。 CRP、D-Dimer、PaCO2与肺动脉收缩压(PASP)呈正相关;PaO2与PASP呈负相关;CRP、D-Dimer 与 PaCO2呈正相关;CRP、D-Dimer 与 PaO2呈负相关。结论:CRP 及 D-Dimer 水平可作为AECOPD患者判断PH严重程度的指标。

  6. A Method of Multi-channel Data Acquisition with Adjustable Sampling Rate

    Directory of Open Access Journals (Sweden)

    Su Shujing

    2013-09-01

    Full Text Available Sampling rate of current signal acquisition systems are singular. Aiming at this shortcoming, a method of multi-channel data acquisition(DAQ with adjustable sampling rate is presented. The method realizes the cut-off frequency of anti-aliasing filter controlled by program with the help of switched-capacitor; by independently pulsing sampling signal of different ADCs, 16-channel sampling rate are adjustable within the range 50ksps, 25ksps, 10ksps, 5ksps, 1ksps. Theoretical analysis and experimental verification pointing at the proposed method are implemented: theoretical analysis shows that parameters of the filter meet the design requirements; experimental results show that cut-off frequency of the anti-aliasing filter matches variable sampling rate very well; choosing appropriate sampling rate according to the characteristics of the measured signal not only can well restore the measured signal, but also prevents system resources from waste. This method can meet needs of testing various signals with different frequency at the same time.  

  7. Comparison of PCT, CRP, D-Dimer, Lactate, TNF-α, IL-1β, IL-6 and lL-10 in Development of Systemic Inflammatory Response Syndrome and Sepsis on Patients with Isolated Head Trauma and Polytrauma

    Directory of Open Access Journals (Sweden)

    Emine Dağlı

    2012-12-01

    Full Text Available Objective: In this study, it was aimed to compare the relationship between Glasgow Coma Scale (GKS, ISS values, PCT, CRP, D-Dimer, laktat, TNF-α, IL-1β, IL-6, IL-10 in patients with polytrauma and isolated head trauma in conjunction with SIRS and sepsis. Material and Method: Total of 68 patients (32 polytrauma, 36 isolated head trauma aged between 18-65 years were enrolled in the study. For 7 days of follow up, the biochemical parameters were analysed on the days 0, 1, 3, 5, 7 and the ISS, GCS score and growth rates of SIRS and sepsis were recorded. Results: It was demonstrated that for patients with isolated head trauma, SIRS (80.6%, sepsis (38.9% and mortality values (71.4% were higher and there is a statistically important linear and inverse relationship between ISS and GCS values (p<0.05. During sepsis and SIRS phases, CRP elevated in both groups, whereas PCT only in the polytrauma group. D-Dimer values were investigated high in both groups, but atypically decreased on day 3 in isolated head trauma group. Lactate, TNF-α and, IL-1β were within reference values, IL-6 and IL-10 values were elevated in both groups but were higher in the polytrauma group. Conclusion: Although multiple variations were detected in serum markers of pro-inflamatory and acute phase proteins, we thought that these are inadequate in predicting mortality and complications such as SIRS and sepsis.

  8. 脊柱关节炎患者D-二聚体和纤维蛋白原检测临床意义初探%Detection and clinical significance of blood of D-Dimer and fibrinogen in spondyloarthritis

    Institute of Scientific and Technical Information of China (English)

    王育凯

    2013-01-01

    Objective To detect the clinical significance of D-Dimer and fibrinogen in the blood of spondyloarthritis (SpA) patients.Methods D-Dimer and fibrinogen of blood were detected among 50 patients with SpA,rheumatoid arthritis (RA),and systemic lupus erythematosus (SLE).further to investigate the relationship of other factors,such as patient global score (PGS),doctor global score (DGS),erythrocyte sedimentation rate (ESR),C-reactvie protein (CRP),platelet (PLT),serum ferritin (SF),and Human Leucocyte Antigen-B27 (HLA-B27).Results The titer of D-Dimer in SpA was significantly lower than that of the RA and SLE group [(535 ±748),(3477 ±4808) and (1285 ±2131) μg/L respectively,P <0.05].The level of fibrinogen in three groups was no significant difference.PGS and DGS was higher in SpA patients with positive D-Dimer and fibrinogen than those with control group (P < 0.05).The values of ESR,CRP and SF in SpA patients with positive D-Dimer and fibrinogen were significantly higher than those in patients with control group.There was positive correlation between D-Dimer and fibrinogen and ESR (r =0.37 and 0.55 respectively,P < 0.01),CRP (r =0.54 and 0.54 respectively,P < 0.01),and DGS (r =0.13 and 0.19 respectively,P<0.01).D-Dimer had positive correlation with PGS (r=0.15,P<0.01).Conclusion The level of D-Dimer and fibrinogen in the blood of SpA patients in increased,and is positively correlated with disease activities.The results indicated that the activation of coagulation-fibrinolytic system may play a role in the pathogenesis of SpA.%目的 探讨检测D-二聚体和纤维蛋白原(Fib)在脊柱关节炎(SpA)患者中的临床意义.方法 比较50例SpA、50例类风湿关节炎(RA)和50例SLE患者血中D-二聚体和Fib水平.并研究其与患者总体评分(PGS)、医生总体评分(DGS)、ESR、CRP、血小板、铁蛋白、HLA-B27等指标的关系.结果 SpA组、RA组、SLE组的血D-二聚体水平分别为(535±748)、(3 477±4 808)和(1 285±2 131

  9. The Brazilian hazard-based cut-off criteria for pesticide registration: a critical appraisal / Critérios de exclusão baseados em perigo adotados no Brasil para registro de pesticidas: Uma avalição crítica

    Directory of Open Access Journals (Sweden)

    Francisco José Roma Paumgartten

    2013-02-01

    Full Text Available Brazil, the world’s top consumer of agricultural pesticides, adopts a unique hazard-based cut-off approach to pesticide registration. Cut-off criteria for mutagenicity, carcinogenicity, teratogenicity, hormonal disturbances and damage to reproductive organs were introduced by the Pesticide Law enacted in 1989. As far as health is concerned, law enforcement is additionally regulated by rules issued by the federal health authority (National Agency for Health Surveillance – ANVISA. Contrasting to the European Union’s hazard-based cut-off criteria for pesticides, Brazilian rules do not make an exception for “negligible” exposures. Moreover, Brazilian regulations have shortcomings (e.g. no reference to relevance of Mode of Action to humans that make cut-off criteria difficult to be put into effect. The deficiencies of regulations and difficulties to consistently apply the hazard-based cut-off criteria are appraised in this article. Adoption of a risk assessment approach or cut-off criteria based on classification into the Globally Harmonized System’s hazard categories 1A and 1B is suggested. Resumo O Brasil, líder mundial do consumo de agro-químicos, adota uma singular abordagem para registro de agrotóxicos que é baseada em critérios de exclusão quanto à periculosidade. Critérios de exclusão para mutagenicidade, carcinogenicidade, teratogenicidade, distúrbios hormonais e dano a órgãos reprodutivos foram introduzidos pela Lei de Agrotóxicos promulgada em 1989. Em relação à saúde, a aplicação da lei é também regulada por portarias publicadas pela autoridade sanitária federal (Agência Nacional de Vigilância Sanitária – ANVISA. Em contraste com os critérios de exclusão baseados na periculosidade que a União Européia usa para agrotóxicos, a regulamentação brasileira não faz exceção para exposições insignificantes. Além disso, a regulamentação brasileira apresenta deficiências (e.g., não faz men

  10. Effects of neurofeedback on the level of D-dimer in patients with cerebral infarction%脑电生物反馈对脑梗死患者D-二聚体的影响

    Institute of Scientific and Technical Information of China (English)

    刘文杰; 胡义奎

    2013-01-01

    目的 探讨超脑电生物反馈对脑梗死患者的纤溶系统指标D-二聚体(D-dimer)的影响. 方法 共选取发病72 h内入院的急性脑梗死患者126例,运用随机数字表法分为脑电生物反馈治疗组(治疗组)62例及常规治疗组(对照组)64例,2组患者均接受神经内科常规药物治疗,治疗组在常规治疗基础上给予脑电生物反馈治疗.所有患者在入院时及治疗2周后进行血浆D-二-聚体的检测及美国国立卫生院卒中量表(NIHSS)评分.结果 经2周治疗后,治疗组有效率(88.7%)明显优于常规治疗组(68.7%,P<0.05);2组患者入院时D-二聚体水平高于阴性对照组(P<0.05),2周后2组D-二聚体水平较入院时降低(P<0.05),且治疗组变化幅度较对照组显著(P<0.05). 结论 脑电生物反馈治疗能下调D-二聚体,对脑梗死患者的神经功能有显著改善作用.%Objective To investigate the effects of neurofeedback on the level of D-dimer in the patients with acute cerebral infarction. Methods All 126 patients with cerebral infarction within the first 72 h from stroke onset were randomly divided into the control group(64 cases) and therapy group(62 cases). All patients received routine treatment, and the patients in therapy group were given additional neurofeedback. In both groups, the plasma level of D-dimer was measured by double antibodies sandwich enzyme linked immunosorbent assay (ELISA) at the time of admission and 2 weeks later. According to National Institute of Health Stroke Scale (NIHSS) ,the effect was evaluated at the time of admission and 2 weeks later. Results The score of NIHSS and the level of D-dimer were significantly decreased after therapy in both groups. The efficacy in therapy group was more significant than that in control group (88. 7% vs 68. 7% ,P < 0. 05). Conclusions Neurofeedbak is effective in treating the acute cerebral infarction by decreasing the level of D-dimer.

  11. On the application of plastic concrete cut-off wall in Huashan Reservoir Risk Removal Reinforcement Project%浅谈塑性混凝土防渗墙在花山水库除险加固工程中的应用

    Institute of Scientific and Technical Information of China (English)

    劳正绍; 梁水新; 陆家辉

    2016-01-01

    Plastic concrete cut-off wall is a plastic wall structure with certain compressive strength and impermeability capacity,and lower modulus of elasticity,which can be controlled artificially for curbing leakage,piping,etc.Plastic concrete cut-off wall not only can cut off seepage flow of the dam (soil)body and lower seepage slope in the dam (soil) body,but also can withstand certain vertical and horizontal load.It can adapt to the surrounding dam (soil ) body deformation and foundation deformation,thereby greatly reducing stress in the wall,avoiding wall cracking,saving cement and reducing the cost of the engineering seepage control with remarkable effect.%塑性混凝土防渗墙是一种塑性墙体结构,具有一定的抗压强度和抗渗能力,有较低的弹性模量,并可人为地控制,抑制渗漏、管涌等。塑性混凝土防渗墙不仅能有效截断坝(土)体的渗透水流和降低坝(土)体中渗透坡降,还能承受一定的垂直和水平荷载,能适应周围坝(土)体变形、地基变形,大大减小墙体内应力,避免墙体开裂,且可节约水泥,降低工程防渗造价,效果显著。

  12. Nursing care of sectioned skin-flap ligation for early pedicle cut-off in 93 patients with Ⅲ-grade burns%93例Ⅲ度烧伤患者分段结扎皮瓣早期断蒂的护理

    Institute of Scientific and Technical Information of China (English)

    林玉丹; 黄书润; 邱双双; 李丽香; 沈秋凤

    2011-01-01

    This paper introduces the nursing care of sectioned skin-flap ligation for early pedicle cut-off in 93 patients with Ⅲ-grade burns. During pedicle ligation,nursing care focused on close observation of blood circulation of the skin flap,especially within the 24 hours after ligation,so as to detect and deal with problems as early as possible and prevent ischemia and necrosis of skin flap. Careful and gentle operations to relieve patients' pain on the premise of tight ligation. After ligation,the key points were changing dressings timely to prevent wound infection and suture reaction,as well as early functional exercises after pedicle cut-off. The average time of pedicle cut-off in the 93 patients was 10 days with good therapeutic outcome and without necrosis of skin flap.%对93例接受分段结扎皮瓣早期断蒂的患者进行观察及护理.认为护理要点包括:每次结扎蒂部时均严密观察皮瓣血液循环,特别是结扎后24h内,及时发现问题,并采取积极的处理措施,建立皮瓣情况评估单,预防皮瓣缺血、坏死;结扎时做到耐心沟通,动作轻柔,既保证扎紧蒂部又能减轻患者的疼痛;结扎后加强换药,减少伤口感染及线头反应等并发症;断蒂后尽早行功能锻练.本组平均断蒂时间10d,结扎或断蒂后皮瓣无坏死,随访结果满意.

  13. Chiropractic Adjustment

    Science.gov (United States)

    ... syndrome) A certain type of stroke (vertebral artery dissection) after neck manipulation Don't seek chiropractic adjustment ... Chiropractic treatment. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2015. Shekelle P, et al. Spinal ...

  14. Reliability, validity and cut-off value of the childhood autism spectrum test%儿童孤独症谱系测验量表的信度、效度及临界值

    Institute of Scientific and Technical Information of China (English)

    关智勇; 龚建华; 陈艳琳; 周首俊; 李丽

    2016-01-01

    Objective To explore the applicability of the childhood autism spectrum test (CAST) of children in Mainland China according to autism screening,in order to provide the effective reference for the identification and diagnosis of autism spectrum disorders of children.Methods Two hundreds and fifty-two typical developing children,and 61 autistic children who were confirmed by psychological clinic of Child Healthcare Clinic,Shenzhen Luohu District Maternal and Child Health Care Hospital who were conformed with diagnosis standards of Diagnostic and Statistical Manual of Mental Disorders Fifth Edition(DSM-5) by using CAST Chinese version were assessed,and the reliability and validity analysis were made on the CAST scale.The receiver operating characteristic curve was drew to determine the optimal threshold value,and the sensitivity,specificity and positive predictive value were calculated.Results CAST Chinese version had good reliability,Cronbach's α was 0.880.Split-half reliability coefficient r was 0.821,and the whole scale calibration reliability coefficient was 0.902.There was statistically significant difference between items and the total score(P<0.05).The consistency between the CAST ≥4 years old children and diagnosis standards of DSM-5 reached 0.884(P=0.000).The consistency 3-<4 years old children and diagnosis standards of DSM-5 reached 0.867 (P=0.000).Among the screening of the children who were ≥4 years old,the cut off was 15 scores that the sensitivity and specificity were best.With the children of 3-<4 years old,a designated cut-point should be 17 scores.Conclusions There are good reliability and validity of CAST,which can be used to mainland China,as well as to screen autistic children more than 3 years old.%目的 探讨儿童孤独症谱系测验(CAST)量表在中国大陆儿童孤独症筛查的适用性,为儿童孤独症谱系障碍的识别与诊断提供有效参考.方法 采用CAST量表对252例健康儿童及深圳市罗湖区妇幼

  15. 血浆FIB、FDP及D-二聚体在妊娠期高血压疾病中的临床应用%The clinical application of FIB, FDP and the D - dimer in high blood pressure in pregnancy

    Institute of Scientific and Technical Information of China (English)

    娄峻; 王永利

    2012-01-01

    目的:探讨妊娠期高血压患者血浆FIB、FDP及D-二聚体病理变化.方法:选择健康组非妊娠妇女80名,正常妊娠组62名,妊娠期高血压患者轻度32名、中度40名、重度28名,分别同时测量血浆FIB、FDP及D-二聚体值.结果:妊娠期高血压组血浆中FIB、FDP及D-二聚体的测定值明显高于健康非妊娠组及正常妊娠组,差异均有统计学意义(P<0.05),且随妊娠期高血压病情的严重程度而增加.结论:对于妊娠期高血压疾病临床早期预防、发现、治疗及重度妊娠期高血压疾病的DIC与子癫形成具有临床应用价值.%Objective: To study the pathological changes of FIB, FDP and the D - dimer in plasma of the patients with high blood pressure in pregnancyMethods; The 80 health no - pregnant women and 62 normal pregnancy women and 100 patients with high blood pressure in pregnancy were choose. Of the 100 patients, 32 patients were mild, 40 were moderate, and 28 were severe. FIB, FDP and the D -dimer value in plasma of all the women were measured respectivelyResulte: FIB, FDP and the D - dimer value in plasma of the patients with high blood pressure in pregnancy were significantly higher than that of the health no - pregnant women and the normal pregnancy women ( P <0. 05) . Conclusion; Early prevention, diagnosis and treatment of hypertensive disorder complicating pregnancy have clinical application value for avoiding the occurring of D1C and edampsia

  16. Application of pipe-joint technology in Kaoshantun Reservoir dam concrete cut-off wall construction%接头管法在靠山屯水库大坝混凝土防渗墙施工中的应用

    Institute of Scientific and Technical Information of China (English)

    金文

    2016-01-01

    本文以辽宁锦州义县靠山屯水库大坝混凝土防渗墙施工为例,针对接头施工质量难控制问题,对接头管法施工工艺中接头管下设、拔管时机控制与起拔力确定等关键技术进行了阐述分析,并结合工程实际,提出了混凝土防渗墙接头管施工常见问题及其解决措施,以期对此类地下连续墙施工有所借鉴。%In the paper,Liaoning Jinzhou Kaoshantun Reservoir dam concrete cut-off wall construction is adopted as an example.The key technologies of pipe-joint installation,pipe removal timing control,removal force datermination,etc. during pipe-joint technology construction process are described and analyzed aiming at difficult quality control in joint construction.Engineering practice is combined for proposing common problems and solutions in concrete cut-off wall pipe-joint construction,thereby providing reference for similar underground continuous wall construction.

  17. 全国225家实验室 D-二聚体决定限的调查与分析%National wide survey and analysis on decision limits of D-Dimer in 225 laboratories

    Institute of Scientific and Technical Information of China (English)

    何法霖; 王薇; 钟堃; 张妍; 赵彦; 李国华; 王治国

    2015-01-01

    Objective To calculate and describe the decision limits of 2014 external quality assessment(EQA) programs in D-Dimer of 225 labs.Methods To collectedthe information of decision limits which come from the 2014 External Quality Assessment ( EQA) programs in D-Dimer.All data from maternal and child care service centers , children′s hospitals and corporations were excluded .Then all the abnormal values and errors were eliminated either .Data of 225 labs statistics were processed by Microsoft Excel 2007, which include the mean, median, maximum value, minimum value, P2.5 and P97.5.Weanalyzed the sources of decision limits and then get the data filtered .The reagent manufacturer 's instructions data are reservedas a reference source and data are analyzed according to differentreagents .Results According to the surveys of decision limits sources ,most of thereference sources use the reagent manufacturer′s instructions. According to the surveys,the mean and median of each test project is close .The P2.5 and P97.5 distribution ranges are: D-Dimer(DDU) 0.3 -1.33 μg/ml,D-Dimer(FEU) 0.23 -1.50 μg/ml,with significant differences.According to the surveys , most P2.5 and P97.5 reagent distributions are significantly different . Conclusion The decision limitsof the mean and median of each test item are approximate ,and the P2.5 and P97.5 distributions of each test item are poorly consistent .%目的:统计并描述2014年全国225家回报D-二聚体决定限。方法选择卫生部临床检验中心2014年全国D-二聚体室间质量评价回报结果中参评单位的决定限信息,剔除所有妇幼保健院、儿童医院和各类公司的结果,再剔除所有异常值和错误数据,使用Microsoft Excel 2007对225家实验室进行统计分析,包括平均值、中位数、最小值、最大值、P2.5和P97.5。统计决定限来源,同时对数据进行筛选,保留决定限来源于试剂厂家说明书的数据,

  18. Establishment of reference intervals of plasma D-dimer for different age crowd of a certain hospital%某医院不同年龄人群D-二聚体生物参考区间的建立

    Institute of Scientific and Technical Information of China (English)

    杨明; 齐永志; 李娜; 张海超; 马骢

    2011-01-01

    Objective To establish reference intervals of plasma D-dimer for different age crowd of a certain hospital.Methods Plasma D-dimer of 618 healthy individuals was detected by the automated blood coagulation analyzer ACLTOP.Data of different age groups were statistically analyzed by SPSS 13.0.Results Biological reference intervals were obtained for different age groups:the 30 -50 years group (0 -217 mg/L),the 51 -80 years group (0 -343 mg/L) and the 81 -90 years group (0 -540 mg/L).Conclusions The biological reference intervals derived from our experimental laboratory conditions are more suitable to clinical application.%目的 建立某医院不同年龄人群D-二聚体生物参考区间.方法 用ACLTOP全自动血液凝固分析仪对618名健康体检者的血浆进行D-二聚体检测,运用SPSS 13.0对不同年龄组的数据进行统计分析.结果 得到不同年龄人群D-二聚体生物参考区间:30~50岁0~217 mg/L,51~80岁0~343 mg/L,81 ~90岁0~540 mg/L.结论 本实验室获得的D-二聚体参考区间适合本院临床应用.

  19. D-Dimer Use and Pulmonary Embolism Diagnosis in Emergency Units: Why Is There Such a Difference in Pulmonary Embolism Prevalence between the United States of America and Countries Outside USA?

    Science.gov (United States)

    Pernod, Gilles; Caterino, Jeffrey; Maignan, Maxime; Tissier, Cindy; Kassis, Jeannine; Lazarchick, John

    2017-01-01

    Objective Although diagnostic guidelines are similar, there is a huge difference in pulmonary embolism (PE) prevalence between the United States of America (US) and countries outside the USA (OUS) in the emergency care setting. In this study, we prospectively analyze patients’ characteristics and differences in clinical care that may influence PE prevalence in different countries. Methods An international multicenter prospective diagnostic study was conducted in a standard-of-care setting. Consecutive outpatients presenting to the emergency unit and suspected for PE were managed using the Wells score, STA-Liatest® D-Dimers and imaging. Results The prevalence of PE in the study was 7.9% in low and moderate risk patients. Among the 1060 patients with low or moderate pre-test probability (PTP), PE prevalence was four times higher in OUS (10.7%) than in the US (2.5%) (P < 0.0001). The mean number of imaging procedures performed for one new PE diagnosis was 3.3 in OUS vs 17 in the US (P < 0.001). Stopping investigation in the case of negative D-dimers (DD combined) with low/moderate PTP was more frequent in OUS (92.7%) than in the US (75.7%) (P < 0.01). Moreover, the use of imaging was much higher in the US (44.4% vs 19.2% in OUS) in the case of moderate PTP combined with negative DD. Conclusion Differences between US and OUS PE prevalence in emergency setting might be explained by differences in patients' characteristics and mostly in care patterns. US physicians performed computed tomographic pulmonary angiography more often than in Europe in cases of low/moderate PTP combined with negative DD. Trial Registration ClinicalTrials.gov NCT01221805 PMID:28085911

  20. Salary adjustments

    CERN Multimedia

    HR Department

    2008-01-01

    In accordance with decisions taken by the Finance Committee and Council in December 2007, salaries are adjusted with effect from 1 January 2008. Scale of basic salaries and scale of stipends paid to fellows (Annex R A 5 and R A 6 respectively): increased by 0.71% with effect from 1 January 2008. As a result of the stability of the Geneva consumer price index, the following elements do not increase: a)\tFamily Allowance, Child Allowance and Infant Allowance (Annex R A 3); b)\tReimbursement of education fees: maximum amounts of reimbursement (Annex R A 4.01) for the academic year 2007/2008. Related adjustments will be applied, wherever applicable, to Paid Associates and Students. As in the past, the actual percentage increase of each salary position may vary, due to the application of a constant step value and rounding effects. Human Resources Department Tel. 73566

  1. Salary adjustments

    CERN Multimedia

    HR Department

    2008-01-01

    In accordance with decisions taken by the Finance Committee and Council in December 2007, salaries are adjusted with effect from 1 January 2008. Scale of basic salaries and scale of stipends paid to fellows (Annex R A 5 and R A 6 respectively): increased by 0.71% with effect from 1 January 2008. As a result of the stability of the Geneva consumer price index, following elements do not increase: a) Family Allowance, Child Allowance and Infant Allowance (Annex R A 3). b) Reimbursement of education fees: maximum amounts of reimbursement (Annex R A 4.01) for the academic year 2007/2008. Related adjustments will be implemented, wherever applicable, to Paid Associates and Students. As in the past, the actual percentage increase of each salary position may vary, due to the application of a constant step value and the rounding effects. Human Resources Department Tel. 73566

  2. Prognostic value of Ki67 and p53 in patients with estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer: Validation of the cut-off value of the Ki67 labeling index as a predictive factor

    Science.gov (United States)

    OHARA, MASAHIRO; MATSUURA, KAZUO; AKIMOTO, ETSUSHI; NOMA, MIDORI; DOI, MIHOKO; NISHIZAKA, TAKASHI; KAGAWA, NAOKI; ITAMOTO, TOSHIYUKI

    2016-01-01

    The aim of this study was to evaluate the significance of the Ki67 labeling index and p53 status as prognostic and predictive indicators of operable estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer. Among 697 consecutive patients with primary breast cancer who underwent curative surgery between 2002 and 2013, 308 patients with ER-positive and HER2-negative breast cancer were assessed. The results of the multivariate Cox analysis demonstrated that a high Ki67 labeling index was significantly associated with a short recurrence-free interval (RFI) (p=0.004) and was marginally associated with a worse overall survival (p=0.074). A positive p53 status was not associated with worse outcomes. To validate the cut-off values of the Ki67 labeling index for identifying patients who may benefit from additional chemotherapy, prognostic factors were investigated in breast cancer patients treated postoperatively with endocrine therapy alone. Analysis of receiver operating characteristic curves demonstrated that a Ki67 labeling index cut-off of 20.0% was optimal for predicting recurrence among patients who did not receive adjuvant chemotherapy. The 5-year RFIs for patients with Ki67 <20 and ≥20% were 97.2 and 86.6%, respectively (p=0.0244). A high Ki67 labeling index (≥20%) was significantly associated with large tumors (p<0.01), lymph node metastasis (p=0.0236) and positive p53 status (p<0.001). The univariate analysis demonstrated that Ki67 labeling index ≥20%, lymph node metastasis and progesterone receptor negativity were significant worse prognostic factors for RFI (p=0.0333, 0.0116 and 0.0573, respectively). The Ki67 labeling index was found to be a useful prognostic factor in patients with ER-positive and HER2-negative breast cancer and the cut-off values of the Ki67 labeling index for making a decision regarding adjuvant treatment were validated. PMID:27073684

  3. 死胎患者产前母体D-二聚体水平变化的相关性研究%Correlation Study of Antepartum D-dimer Levels in Stillbirth Patients

    Institute of Scientific and Technical Information of China (English)

    王欲; 杜鹃

    2011-01-01

    目的 探讨死胎患者分娩前母体D-二聚体水平的变化.方法比较27例死胎患者和293例健康孕妇产前凝血与纤溶检验学指标的差异,分析死胎患者产前D-二聚体浓度与年龄、孕次、产次、孕周、血小板计数、凝血功能、肝脏功能等临床指标的相关性.结果死胎患者的产前母体D-二聚体水平[409(102~18 021)μg/L]高于健康孕妇[216(1O~850)μg/L](P=0.000),而凝血酶原时间、凝血酶原时间活动度、凝血酶原标准化比值、活化部分凝血酶原时间、纤维蛋白原含量、凝血酶凝结时间与健康孕妇比较无统计学差异(P>0.05).死胎患者D-二聚体水平与年龄、孕次、产次、孕周、血小板计数、凝血功能(凝血酶原时间、凝血酶原时间活动度、凝血酶原标准化比值、活化部分凝血酶原时间、纤维蛋白原、凝血酶凝结时间)、肝脏功能(白蛋白、球蛋白、谷丙转氨酶、谷草转氨酶、碱性磷酸酶、胆碱酯酶、总胆红素)等18项指标均不相关(r分别为0.114、0.239、0.174、-0.182、-0.268、-0.160、0.267、0.006、-0.131、-0.204、-0.023、-0.277、-0.069、0.165、0.249、-0.041、-0.103、-0.016,P均>0.05).结论死胎患者分娩前D-二聚体水平升高,母体血液不但呈高凝状态,继发性纤维蛋白溶解也增强.%Abstract Objective To investigate the antepartum variation of D-dimer in stillbirth patients. Methods We compared the indicators of coagulation and fibrinolysis between stillbirth pregnant women (n = 27) and normal pregnant women (n = 293), and analysed the correlation between antepartum D-dimer concentration and maternal age, gravidity, parity, gestational weeks,platelet count,coagulation function,liver function in stillbirth patients. Results D-dimer concentration in stillbirth pregnant women were higher than that in normal pregnant women (P = 0.000), and there was no statistical difference in prothrombin time, prothrombin time activity

  4. Research Progress on the Relationship of Coronary Heart Disease and D-dimer,Lipoprotein(a),Fibrinogen%D-二聚体、脂蛋白(a)、纤维蛋白原和冠心病关系研究进展

    Institute of Scientific and Technical Information of China (English)

    龚小鹏

    2012-01-01

    冠心病(CHD)与D-二聚体、脂蛋白(a)、纤维蛋白原(FG)有着密切的关联,CHD患者中D-二聚体、脂蛋白(a)、FG较高,但它们之间相互作用的机制仍不明确.近年来的研究显示,D-二聚体、脂蛋白(a)和FG可能参与CHD的发病过程,因此通过测定D-二聚体、脂蛋白(a)和FG在不同危险程度的CHD患者中的含量,评估它们对于CHD的发生、发展具有重要意义.%Coronary heart disease( CHD)is closely associated with D-dimer,lipoprotein( a)and fibrino-gen( FG),CHD patients have higher levels of D-dimer,lipoprotein( a),fibrinogen while the mechanism of the interaction between them remains unclear. In recent years, studies have shown that D-dimer,lipoprotein ( a )and fibrinogen may be involved in the pathogenesis of coronary heart disease, so by measuring D-dimer, lipoprotein( a )and fibrinogen level in patients with coronary heart disease is of great significance for assessing the genesis and development of CHD.

  5. Effect of Tongmai Jiangzhi Oral Liquid (通脉降脂口服液) on Serum P-selectin,von Willebrand Factors and D-Dimer in Patients with Atherosclerosis

    Institute of Scientific and Technical Information of China (English)

    沈晓君; 史云菊; 王玲

    2004-01-01

    Objective: To explore the role of cytokines on the pathogenesis of atherosclerosis, and the lectins (Ps), von Willebrand (vWF), and D-dimer (D-D) in atherosclerosis (AS) patients. Methods: Sixtythree AS patients were randomly divided into the treated group ( n = 33, treated with TMJZ, 10 ml each time, three times a day) and the control group (n = 30, treated with Lovastatin, 10 mg, once daily). The levels of serum lipids (enzymatic methods), Ps, vWF, and D-D were measured before and after 8 weeks of treatment. Results: Serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), apo-protein B-100 (apoB-100) were significantly decreased (P<0.05 or P< 0.01) and high-density lipoprotein cholesterol (HDL-C) was significantly raised (P<0.05) after TM JZ treatment. Serum Ps,vWF, and D-D also declined (P<0.05) after treatment. There was no significant difference between the treated and the control groups in these parameters except serum HDL-C level. Conclusion: TMJZ has good therapeutic effect in regulating serum lipids, improving endothelial cell function, inhibiting activation of platelets, and preventing the disturbance of blood coagulation/fibrinolysis function in patients with AS.

  6. LC Filter Design for Wide Band Gap Device Based Adjustable Speed Drives

    DEFF Research Database (Denmark)

    Vadstrup, Casper; Wang, Xiongfei; Blaabjerg, Frede

    2014-01-01

    the LC filter with a higher cut off frequency and without damping resistors. The selection of inductance and capacitance is chosen based on capacitor voltage ripple and current ripple. The filter adds a base load to the inverter, which increases the inverter losses. It is shown how the modulation index......This paper presents a simple design procedure for LC filters used in wide band gap device based adjustable speed drives. Wide band gap devices offer fast turn-on and turn-off times, thus producing high dV/dt into the motor terminals. The high dV/dt can be harmful for the motor windings and bearings...... affects the capacitor capacitor and the inverter current....

  7. 概率截断值对先进轻水堆核电厂应急计划区划分的影响%Impact of Cut-Off Probability on Emergency Planning Zone Sizing for Advanced Light Water Reactors

    Institute of Scientific and Technical Information of China (English)

    黄挺; 曲静原; 曹建主

    2012-01-01

    In 1997, NRC performed an evaluation of emergency planning for the evolutionary and advanced light water reactors, and indicated that no changes to emergency planning (EP) requirements were warranted in the existing technical framework. However, NRC also recognized if the lower probability of severe accidents or the longer time period between accident initiation and release of radioactive material was considered, the changes to EP requirements for advanced light water reactors might be warranted and the emergency planning zone (EPZ) sizing might be reduced. This means that if the accidents which probabilities are lower than a cut-off probability are not considered, there may be a significant impact on the EPZ sizing. AP1000 was selected as an example in this study and the probable impacts of different cut-off probabilities were studied by using MACCS code in accordance with the NUREG-0396 method. The results show that, only if the cut-off probability is higher than the occurrence probability of the accident which has relatively serious consequence and high probability, there will be a significant impact on the EPZ sizing for the advanced light water reactor.%1997年,美国核管会(NRC)在对被动与改进型先进轻水堆的应急计划进行评估后指出,在现有的技术框架下先进轻水堆的应急计划应当保持不变,但也表明如果考虑到严重事故发生概率更低,事故的延迟时间更长,则有可能简化对先进轻水堆的应急计划要求,减小应急计划区.这意味着,如果在事故选择时不考虑低于某一概率截断值的事故,则有可能对先进轻水堆核电厂应急计划区的划分产生较大的影响.本文以AP1000核电机组为例,参考美国NUREG-0396的方法,使用MACCS程序对选取不同事故概率截断值可能产生的影响进行研究.研究结果表明,只有当概率截断值高于某些相对概率较大、而后果较为严重的事故的发生概率时,才会对先进轻水堆应

  8. Determinación del valor umbral de tamizaje de la glicemia en ayunas, para identificar la intolerancia a los carbohidratos, en mujeres con síndrome de ovarios poliquísticos Determination of fasting plasma glucose cut-off valuefor the identification of abnormal carbohydrate tolerance in women with polycystic ovarian syndrome

    Directory of Open Access Journals (Sweden)

    Yai-Linn Chang

    2012-12-01

    Full Text Available Objetivo: determinar el valor predictivo de la glucosa en ayunas, para identificar intolerancia a los carbohidratos en pacientes con síndrome de ovario poliquístico. Materiales y métodos: a 100 mujeres con diagnóstico de síndrome de ovario poliquístico, se les realizó una prueba de tolerancia a 75 g de glucosa. Resultados: la sensibilidad para una cifra umbral de 101 mg/dl, fue de un 41,7%, IC 95%: 23% - 63%, y la especificidad de un 92,1%, IC95 %:83% - 97%. Con un valor predictivo positivo del 62,5%, y negativo del 83,3%.El valor de corte óptimo fue de 93mg /dl, con una sensibilidad del 75%, IC 95%: 53%-89%, y una especificidad del 73,7%, IC 95%: 62%-83%. La cifra de corte umbral óptima de la glicemia en ayunas para el tamizaje de intolerancia en mujeres con SOPQ, fue de 93 mg/dl. Conclusiones: las recomendaciones actuales para diagnosticar intolerancia a los carbohidratos, en mujeres con síndrome de ovario poliquístico, no son apropiadas.Objective: To determine the predictive value of fasting glucose to identify abnormal carbohydrate tolerance in patients with polycystic ovary syndrome. Materials and methods: 100 women diagnosed with polycystic ovary syndrome underwent a tolerance test toa 75 gdose of glucose. Results: Sensitivity for a threshold value of 101 mg/dl was 41.7% (95% C.I.: 23% - 63% and specificity 92.1% (95% C.I.: 83% - 97%; with a positive predictive value of 62.5% and a negative predictive value of 83.3%. The optimum cut-off value was 93 mg/dL, with a sensitivity of 75% (95% C.I.: 53% - 89% and a specificity of 73.7% (95% C.I.: 62% - 83%. The optimum fasting plasma glucose cut-off value for intolerance in women with PCOS was 93md/dL. Conclusions: The current recommendations for diagnosing abnormal carbohydrate tolerance in women with polycystic ovary syndrome are not appropriate.

  9. Approaches for predicting long-term sickness absence. Re: Schouten et al. "Screening manual and office workers for risk of long-term sickness absence: cut-off points for the Work Ability Index".

    Science.gov (United States)

    van Amelsvoort, Ludovic Gpm; Jansen, Nicole W H; Kant, I Jmert

    2015-05-01

    an overestimation of the predictive value. A methodological approach of related issues is provided in the works of Glymour et al (5) and Hamilton et al (6). This phenomenon is even more clearly illustrated by the predictive properties of the workability index, as described by Alavinia et al (7, page 328), which reported that "when adjusted for individual characteristics, lifestyle factors, and work characteristics, two dimensions of the WAI were significant predictors for both moderate and long durations of sickness absence: (i) the presence of sickness absence in the past 12 months prior to the medical examination and (ii) experienced limitations due to health problems." So, when applied to the study by Schouten et al (1), this means that most of the predictive value would be related to the factors "sickness absence in the past 12 months". In addition, we object to the use of the term "screening" in the Schouten et al study as it includes workers with the intended outcome (long-term sickness absence). One can identify three separate aims to study the longitudinal association between risk factors and subsequent long-term sickness absence: (i) to establish causal risk factors for long-term sickness absence, often to find clues for primary preventive strategies (beyond the scope here); (ii) to identify high-risk workers who are still at work and might benefit from an intervention before sickness absence occurs (secondary prevention); and (iii) to identify workers on sick leave who might suffer a below-average return-to-work rate or have a high risk for the recurrence of (long-term) sickness absence and might benefit from intensification or optimization of the return-to-work process (tertiary prevention). In this light, one needs to separate screening instruments from predictive instruments and reserve the term "screening" for the situation as defined by Wilson and Junger (8, page 7): "The object of screening for disease is to discover those among the apparently well

  10. Relationship of pneumonia severity index with serum levels of NT?proBNP and D?Dimer in elderly patients with community?acquired pneumonia%老年社区获得性肺炎患者PSI分级与NT-proBNP及血清D-二聚体的关系

    Institute of Scientific and Technical Information of China (English)

    邱建凯; 尹占良; 张芳芳; 李令娟; 姚海珍

    2016-01-01

    目的 探讨老年社区获得性肺炎(CAP)患者肺炎严重度指数(PSI)分级与血清N末端脑钠肽前体(NT-proBNP)和D-二聚体(D-Dimer)水平的关系.方法 选择本院收治的162例老年CAP患者为老年肺炎组,正常对照组为50例无基础疾病的健康体检人群.患者入院后24 h内进行临床数据收集,评估PSI,根据入院后28 d内是否死亡分为存活组与死亡组.同时检测老年肺炎组及正常对照组血清NT-proBNP与D-Dimer浓度,分析并比较CAP患者PSI分级与血清NT-proBNP及D-Dimer水平的关系.结果 (1)老年肺炎组血清NT-proBNP、D-Dimer水平明显高于正常对照组(P<0.05).(2)老年肺炎组患者血清NT-proBNP及D-Dimer水平随PSI分级增加而升高.不同PSI分级患者间NT-proBNP及D-Dimer水平比较,差异均有统计学意义(P<0.05).CAP患者死亡率随PSI分级增加而上升(P<0.05).(3)死亡组在入院时PSI评分、血清NT-proBNP及D-Dimer水平均明显高于存活组,差异有统计学意义(P<0.05).结论 NT-proBNP、D-Dimer不仅可作为诊断老年CAP的有效指标,而且与老年CAP患者PSI分级有一定的关系.%Objective To explore the relationship of pneumonia severity index(PSI) with serum levels of NT-proBNP and D-Dimer in elderly patients with community-acquired pneumonia ( CAP ) . Methods 162 elderly cases of CAP in our hospital were chosen as senile pneumonia group from March 2012 to July 2015. Fifty cases of healthy people without basic diseases were selected as normal control group. Clinical data of CAP patients were collected within 24 h after admission and PSI was assessed. All the patients were divided into survival group and death group within 28 d after admission. Serum levels of NT-proBNP and D-Dimer were detected in two groups. The relationship of PSI with serum levels of NT-proBNP, D-Dimer was analyzed. Results ( 1) Serum levels of NT-proBNP and D-Dimer in senile pneumonia group were significantly higher than those in normal control group( P

  11. D-二聚体在老年下肢深静脉血栓预测中的临界值探讨%Critical Value of D-dimer in Elderly Patients in Lower Limb Deep Vein Thrombosis

    Institute of Scientific and Technical Information of China (English)

    殷明春

    2014-01-01

    Objective:To investigate the D-dimer (DD) in elderly patients with lower extremity deep vein thrombosis (DVT) of the prediction critical value,in order to provide reference for clinical diagnosis of senile lower limb DVT.Methods:482 patients with DD enzyme-linked immunosorbent method of elderly hospitalized patients with clinical data were retrospectively analyzed,73 cases of lower limb DVT occurred for DVT group,in which 34 cases aged 60~79,p 80,39,409 cases lower extremity DVT occurred not as a set of DVT.Results:DVT group average DD(2.67±0.61)mg/L,not DVT group is(1.71±0.35)mg/L,DVT is significantly higher than non DVT group (P0.05),specificity is higher than in patients with 60~69 years old or 80 years old patients (P0.05),2.0mg/L,3.0mg/L in two age groups the sensitivity and specificity of comparative differences statistically significant (P0.05),对60~69岁患者诊断特异性高于≥80岁患者(P0.05),2.0mg/L、3.0mg/L时两个年龄段的敏感性及特异性比较差异具有统计学意义(P<0.05)。结论:60~69岁老年患者DD预测下肢DVT时临界值以0.5mg/L适宜,年龄≥80岁的老年患者则DD临界值调整为2.0mg/L更为合适。

  12. Imaging of deep venous thrombosis in patients using a radiolabelled anti-D-dimer Fab' fragment ({sup 99m}Tc-DI-DD3B6/22-80B3): results of a phase I trial

    Energy Technology Data Exchange (ETDEWEB)

    Macfarlane, David [University of Queensland, School of Medicine, Brisbane (Australia); Socrates, Angelides; Larcos, George [University of Sydney, Department of Medicine, Sydney (Australia)]|[Westmead Hospital, Department of Nuclear Medicine and Ultrasound, Westmead (Australia)]|[Westmead Hospital, Centre for Biomedical Imaging and Research, Westmead (Australia); Eisenberg, Paul [Amgen Inc, Thousand Oaks, CA (United States); Roach, Paul [University of Sydney, Department of Medicine, Sydney (Australia)]|[Royal North Shore Hospital, Nuclear Medicine, St. Leonards (Australia); Gerometta, Michael [Agen Biomedical Pty Ltd, Brisbane (Australia); Smart, Richard; Tsui, Wendy [St. George Hospital, Nuclear Medicine Department, Sydney (Australia)]|[University of New South Wales, Department of Medicine, Sydney (Australia); Scott, Andrew M. [Austin Hospital, Centre for PET, Melbourne (Australia)]|[Ludwig Institute, Melbourne (Australia)

    2009-02-15

    {sup 99m}Tc-DI-DD3B6/22-80B3 (ThromboView registered, hereafter abbreviated to {sup 99m}Tc-DI-80B3 Fab') is a radiolabelled humanised monoclonal Fab' fragment with affinity and specificity for D-dimer domains of cross-linked fibrin. Detection of thromboembolic events has been demonstrated in canine models. The study objectives were evaluation of safety and characterisation of biodistribution, immunogenicity and pharmacokinetic profile of increasing doses of {sup 99m}Tc-DI-80B3 Fab' in subjects with acute lower-limb DVT. Twenty-six patients with acute lower limb DVT were enrolled. Of these, 21 received a single intravenous dose of 0.5 mg (n = 6), 1.0 mg (n = 9) or 2 mg (n = 6) {sup 99m}Tc-DI-80B3 Fab'. Blood and urine samples and gamma camera images were collected to 24 h after administration for pharmacokinetic and dosimetry analysis. Vital signs, electrocardiography, hematological and biochemical data and human anti-human antibody (HAHA) levels were monitored for up to 30 days following administration. Patients were assigned to either planar or single photon emission computed tomographic (SPECT) imaging of the thorax at 4 h following injection. Thirty-five adverse events were reported in 15 of the 21 subjects. Those deemed possibly related to administration of {sup 99m}Tc-DI-80B3 Fab' included mild hypertension, mild elevation of LD (lactate dehydrogenase) and moderate elevation of ALT (alanine transaminase). HAHA assays remained negative. Pharmacokinetics and organ dosimetry were comparable to prior normal volunteer data. Localisation of Thromboview registered to sites of known thrombus was evident as early as 30 min post-injection. In subjects with acute DVT, {sup 99m}Tc-DI-80B3 Fab' was well tolerated with favourable characteristics for the detection of acute venous thrombosis. (orig.)

  13. 肝硬化患者血浆D-二聚体的检测与分析(比浊法)%Testing and analysis of Plasma D-dimer in patients with liver cirrhosis

    Institute of Scientific and Technical Information of China (English)

    于广名

    2010-01-01

    目的:经过检测不同临床分级的肝硬化患者血浆中D-二聚体(D-Dimer)的水平,进一步来研究其鉴别诊断的意义和肝病凝血功能障碍的发病机理.方法:应用日本Sysmex CA1500检测仪,采用免疫比浊法来检测样本的D-二聚体含量.结果:肝硬化患者D-二聚体水平明显高于对照组(健康人),差异有统计学意义(P<0.01).肝硬化患者肝功能A、B、C级者血浆D-二聚体水平逐渐升高,分别与对照组进行两两比较,差异均有统计学意义(P<0.01).肝硬化并消化道出血者血浆D-二聚体水平非出血者高,差异有统计学意义(P<0.01).肝硬化患者HBsAg阳性的血浆D-二聚体水平较HBsAg阴性高,差异有统计学意义(P<0.05).故病情及肝功能损害越重,血浆D-二聚体含量越高.结论:血浆D-二聚体的含量在肝硬化各临床分级的患者血浆中明显增高,患者的病情越严重、肝脏功能越差则其血浆中D-二聚体的含量就越高.

  14. D-二聚体定量检测在排除静脉血栓性疾病中的作用——推荐性指南(CLSI H59-P)解读%Value of D-dimer quantitative detection in precluding venous throbosis-understanding of CLSI H59 guide

    Institute of Scientific and Technical Information of China (English)

    陈华云; 胡晓波

    2011-01-01

    @@ 2010年,临床实验室标准化研究所(Clinical andLaboratory Standards Institute,CLSI)出版了H59-P指南.该指南指出,在低、中临床危险度峰值时,定量检测D-二聚体(D-Dimer,D-D)用作静脉血栓栓塞症(VTE)的排除性诊断.

  15. The Value of D-dimer and Fibrinogen in the Diagnosis of Coronary Artery Disease%血浆D-二聚体和纤维蛋白原检测在冠心病临床诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    陈高科

    2014-01-01

    Objective:To study the significance of detection of plasma D-dimer and fibrinogen in the diagnosis of coronary artery disease.Method:The level of plasma D-dimer and fibrinogen of 108 patients with different types of coronary artery diseases and 62 health people from May 2011 to Dec 2012 were detected. The results of plasma D-dimer and fibrinogen were analyzed.Result:The levels of plasma D-dimer and fibrinogen of acute myocardial infarction(AMI) patients were higher than those of healthy people,unstable angina pectoris(UAP) and stable angina pectoris(SAP) patients(P0.05).Conclusion:The detection of plasma D-dimer and fibrinogen contribute to the diagnosis and typing of coronary heart disease.%目的:研究血浆D-二聚体和纤维蛋白原检测在冠心病临床诊断中的意义。方法:对2011年5月-2012年12月在笔者所在医院就诊的108例不同类型的冠心病患者及62例正常体检者的血浆D-二聚体及纤维蛋白原水平进行检测,分析D-二聚体及纤维蛋白原检测结果在冠心病临床诊断中的意义。结果:急性心肌梗死患者的D-二聚体及纤维蛋白原水平高于正常体检者、不稳定型心绞痛患者和稳定型心绞痛组患者,差异均有统计学意义(P0.05)。结论:临床血浆D-二聚体及纤维蛋白原水平的检测有助于冠心病分型诊断。

  16. 凝血四项和D-二聚体检测对子痫前期的应用价值%The Application Value of Detection of Four Items of Coagulation Routine and D-Dimer in the Early Stage of Eclampsia

    Institute of Scientific and Technical Information of China (English)

    张佳夫; 李艳玲

    2016-01-01

    Objective To discuss the application value of the detection of coagulation routine and D-Dimer for preeclampsia.Methods Detection of 67 cases in PE, 60 normal pregnant women and 70 non-pregnant women in coagulation routine and D-Dimer levels.ResultsThe time of TT, PT and the level of D-dimer in observation group were higher than those in control group (P<0.05). The TT and PT time and the level of D-dimer of severe PE patients were higher than those of low-grade PE patients (P<0.05).Conclusion The blood of pregnant women with preeclampsia is a high coagulation state, the pathological and physiological basis of eclampsia, MODS and DIC and the D-dimer level can be used as one of the indicators to judge the severity of PE.%目的:探讨检测凝血四项[凝血酶时间(TT)、部分凝血活酶时间(APTT)、凝血酶原时间(PT)和纤维蛋白原含量(FBG)]和D-二聚体(D-Dimer)在子痫前期(PE)的应用价值。方法检测67例PE孕妇、60例正常孕妇和70例非孕期妇女的凝血四项、D-Dimer和hs-CRP水平。结果观察组TT、PT时间和D-D水平高于对照组(P <0.05),APTT时间和FBG水平低于对照组(P<0.05);重度PE患者TT、PT时间和D-D水平高于轻度PE患者(P<0.05),APTT时间和FBG水平低于轻度PE患者(P<0.05)。结论子痫前期孕妇血液呈高凝状态,可能是发生子痫抽搐、MODS和DIC的病理生理基础,D-D水平可作为初步判断PE病情严重程度的指标之一。

  17. On the Cut-off Point for Combinatorial Group Testing

    DEFF Research Database (Denmark)

    Fischer, Paul; Klasner, N.; Wegener, I.

    1999-01-01

    The following problem is known as group testing problem for n objects. Each object can be essential (defective) or non-essential (intact). The problem is to determine the set of essential objects by asking queries adaptively. A query can be identified with a set Q of objects and the query Q is an...

  18. Man Cuts Off Penis in Fit of Religious Fervor

    Institute of Scientific and Technical Information of China (English)

    朱土英

    2002-01-01

    一位菲律宾的男子自残,用利刃割下了自己的阳物。主要原因是其妻离他而去。到首都马尼拉去做保姆(housemaid)了。他想象自己的阳物正像眼镜蛇一样逼近其他女性(his penis as a"cobra"(眼镜蛇)drawing him towardwomen),而《马太福音》曾云:If your hand or your foot causes you to sin,cut it offand throw it away.于是,此君对自己下了“毒手”。可幸的是,手术成功,割下的阳物又被接上。只是短了20%……

  19. Jealous Wife Cuts Off Husband’s Testicle

    Institute of Scientific and Technical Information of China (English)

    杨芳

    2001-01-01

    本文提供了一个有用的表达:extra-marital affair(婚外恋),本文提供了一个惊人的案例:香港一女子把不忠诚的丈夫的一个睾丸割掉了,本文还提供了一个不争的事实:婚外恋苦人害己!】

  20. Tentative Colistin Epidemiological Cut-Off Value for Salmonella spp

    DEFF Research Database (Denmark)

    Agersø, Yvonne; Torpdahl, Mia; Zachariasen, Camilla

    2012-01-01

    The objective of this research was to determine minimal inhibitory concentration (MIC) population distributions for colistin for Salmonella on subtype level. Furthermore, we wanted to determine if differences in MIC for colistin could be explained by mutations in pmrA or pmrB encoding proteins...... involved in processes that influence the binding of colistin to the cell membrane. During 2008–2011, 6,583 Salmonella enterica subsp. enterica isolates of human origin and 1931 isolates of animal/meat origin were collected. The isolates were serotyped, and susceptibility was tested towards colistin (range...... 1–16 mg/L). Moreover, 37 isolates were tested for mutations in pmrA and pmrB by polymerase chain reaction (PCR) and DNA sequencing. MIC distribution for colistin at serotype level showed that Salmonella Dublin (n=198) followed by Salmonella Enteritidis (n=1247) were less susceptible than “other...

  1. [ANTHROPOMETRIC PARAMETERS' CUT-OFF POINTS FOR DIAGNOSIS OF SARCOPENIA].

    Science.gov (United States)

    Canda Moreno, Alicia S

    2015-08-01

    Introducción: la sarcopenia es un síndrome caracterizado por baja masa muscular junto con pérdida de fuerza y/o disminución del rendimiento físico. Debido al envejecimiento de nuestra población, se ha producido un aumento de su prevalencia relacionada con la edad, a la que se suman otros factores causados por ciertas enfermedades o la malnutrición. Objetivo: ofrecer una herramienta para el diagnóstico de sarcopenia que determine de forma accesible la pérdida de masa muscular. Material y métodos: se realizó un protocolo antropométrico estandarizado en 883 varones y 506 mujeres, sanos y activos, de edad entre 20 y 39 años. Se calcularon los siguientes índices de desarrollo muscular: perímetros (brazo, antebrazo, muslo y pierna), perímetros corregidos (brazo, muslo y pierna), áreas musculares transversales (CSA de brazo, muslo y pierna) y masa muscular total (kg), en porcentaje (%) y relativa a la talla (kg/m2) mediante la ecuación de Lee. Se fijó como punto de corte el percentil 2,5 (rango inferior del 95% del intervalo de confianza) para las variables estudiadas. Resultados: se encontraron diferencias significativas (p muscular fue en varones de 9,1 kg/m2, y en mujeres de 7,3 kg/m2. Y para las CSA (cm2) varón vs. mujer: brazo, 37,7 vs. 24,2; muslo, 154,3 vs. 115,8; y pierna, 78,8 vs. 60,2. Conclusiones: existe dimorfismo sexual que exige criterios diagnósticos diferenciados. La técnica antropométrica puede servir como screening de sarcopenia en el estudio de grandes poblaciones.

  2. New oral cut-off time limits in NSW.

    Science.gov (United States)

    Nittis, Maria; Franco, Michele; Cochrane, Clint

    2016-11-01

    Standard collection procedure for the investigation of allegations of penile - oral assault has traditionally been the oral swab. Review of both the literature and NSW forensic laboratory results from oral swabbing has highlighted the sub-optimal nature of this method for the recovery of both sperm and offender DNA. 554 oral swabs, collected in NSW from 2010 to 2015, were analysed. Sperm detection occurred in only 4.2%. In the same period there was analysis of 104 oral rinses (of which 16.4% were positive for sperm) and 71 peri-oral samples (of which 18.3% were positive for sperm). As a result, a decision was made to revise forensic collection guidelines for sample collection in cases of penile - oral assault. Oral swabbing is no longer recommended. Current NSW forensic collection guidelines recommend the collection of both an oral rinse and a peri-oral (lip) swab. Samples are to be taken in the first 12 h after a penile - oral assault in all cases where there is a suspicion of oral assault. Oral collections may be extended to 24 h post penile - oral assault in those cases where there is either a clear recollection of ejaculation into the mouth (or ejaculation elsewhere prior to penile penetration of the mouth) or in those cases where a complainant is clear that there had been penile penetration of the mouth but is unable to recall whether or not ejaculation has taken place.

  3. Characteristics Of Fused Couplers Below Cut-Off

    Science.gov (United States)

    Meyer, T. J.; Tekippe, V. J.

    1989-02-01

    A number of different architectures are being explored for the utilization of optical fiber in the subscriber loop. In addition to reliability and maintainability, cost is a prime consideration since full implementation of fiber in the local loop will not occur until it is economically viable. It is becoming increasingly clear that in order to accommodate a number of ISDN applications, including high definition television (HDTV), singlemode fiber with a singlemode laser at the terminal end will be required. The situation at the subscriber end is quite different, however. The data rates are expected to be low on the return path to allow for POTS ( plain old telephone service) and some data transfer. When this requirement is combined with cost and reliability considerations, the inexpensive lasers developed for the CD (compact disk) market become quite attractive. The biggest disadvantage of this source is that the fiber which is optimized for singlemode operation at 1300nm tends to be multimode in the 800nm band where these lasers operate. Previous papers have considered such effects as modal noise and pulse dispersion when using these lasers with fiber that is singlemode in the 1300nm band.[1] Another consideration is the passive components required to implement such an architecture. Figure 1 shows a typical bidirectional design with full duplex operation on a single fiber. The key component is the 800/1300 wavelength division multiplexer/demultiplexer (WDM). Because of the multimode nature of the fiber in the 800nm band, all fiber approaches to fabricating the WDM, such as the fused beconical taper (FBT) approach, raise new issues which are not encountered, for example, with 1300/1500nm WDM's.[2] In this paper we discuss the effects of the multimode behavior of the fiber on the performance of fused couplers and WDM's.

  4. How to preserve symmetries with cut-off regularized integrals?

    CERN Document Server

    Varin, T; örtel, M; Urban, M

    2006-01-01

    We present a prescription to calculate the quadratic and logarithmic divergent parts of several integrals employing a cutoff in a coherent way, i.e. in total agreement with symmetry requirements. As examples we consider one-loop Ward identities for QED and a phenomenological chiral model.

  5. Correlative Analysis of the Relationships and Differences on D-dimer, Fibrinogen and Antithrombin Ⅲ Between Varied Clinical Periods of Cerebral Infarction%D-D、Fb和AT-Ⅲ在脑梗死不同时期的变化及相关性分析

    Institute of Scientific and Technical Information of China (English)

    徐威香; 武蓉珍; 胡晓蕾

    2012-01-01

    目的:探讨血浆D-二聚体(D-D)、纤维蛋白原(Fb)和抗凝血酶Ⅲ(AT-Ⅲ)在脑梗死(CI)不同时期的变化及其临床意义.方法:根据临床特征,对260例CI患者进行分组,其中CI急性期组80例、进展期组41例、非进展期组65例、康复期组74例;90例体检健康者为正常对照组.采用SYSMEX CA7000血凝仪分别检测其血浆D-D、Fb和AT-Ⅲ水平.结果:CI急性期、进展期、非进展期患者D-D、Fb含量均明显高于正常对照组(P<0.01),AT-Ⅲ低于正常对照组(P<0.01);脑梗死组中,D-D与AT-Ⅲ呈负相关(P<0.01),D-D与Fb呈正相关(P<0.01),AT-Ⅲ与Fb无相关性.结论:CI患者D-D、Fb、AT-Ⅲ变化显著,D-D升高伴随AT-Ⅲ含量降低,提示D-D、Fb、AT-Ⅲ共同参与了梗死发生发展的病理生理过程,可作为CI临床危险分级和病情监测的指标.%Objective To investigate the differences and its clinical significance of D-dimer, fibrinogen and antithrombin Ⅲ between varied clinical periods of cerebral infarction( CI). Methods 328 CI patients were rolled into the study, and they were divided into four groups due to their different clinical periods as follows: group acute period (80) , group progressing(41) , group non-pro-gressing(65) , group convalescence(74). And, 90 healthy volunteers were rolled into the normal control group. Their plasma D-dimer, fibrinogen and antithrombin HI were detected on SYSMEX CA7000 automatic coagulation analyzer. Results D-dimer and fibrinogen of CI patients in the acute, progressing and non-progressing periods were significantly higher (P <0.01) than those of healthy volunteers, while antithrombin Ⅲ of them was significantly lower (P<0.01) than that of healthy volunteers. In CI patients, D-dimer correlated negatively with antithrombin Ⅲ, while positively with fibrinogen. No significant relationship was observed between antithrombin Ⅲ and fibrinogen. ConclUSin D-dimer, fibrinogen and antithrombin Ⅲ of CI patients varied significantly

  6. 血浆D-二聚体及纤维蛋白原在非小细胞肺癌患者围术期监测中的应用价值%Value of plasma D-dimer,fibrinogen levels monitoring in non-small cell lung cancer patients in perioperative period

    Institute of Scientific and Technical Information of China (English)

    江吕泉; 高坤祥; 郑建; 陈建; 吴昊; 陈林松

    2013-01-01

    Objective Bleeding or thrombotic diseases are easily to be found in non - small cell lung cancer ( NSCLC ) patients, because the equilibrium of their coagulation system might be disturbed due to tumor burden or surgical injury. In the study, we studied the value of plasma D - dimer and fibrinogen levels monitoring in patients with non - small cell lung cancer before and after surgery. Methods The plasma D - dimer and fibrinogen levels were measured in 254 patients with non - small cell lung cancer and 52 patients with benign lung tumor, and then we followed up to record the D - dimer and fibrinogen levels change in postoperative patients. Results The plasma levels of D - dimer and fibrinogen in non - small cell lung cancer patients were found to be significantly higher than those in patients with benign lung tumor ( P < 0. 01). Significant differences in D - dimer and fibrinogen levels were found among different stages of non - small cell lung cancer ( P < 0. 01 ) , which suggested that coagulation and fibrinolysis dysfunction in patients with non - small cell lung cancer aggravated along with the progression of disease. The D - dimer and fibrinogen levels kept at a high level or rose suddenly after a transient decrease in 15 patients who had thrombotic diseases after operation. Conclusions Monitoring the plasma D - dimer and fibrinogen levels in patients with non - small cell lung cancer before and after operation helps find out those who have high risk of thrombotic diseases and preventing thrombtic disease after operation. It also helps us to strive for early prevention, early diagnosis,early treatment,nd to improve the prognosis of the patients.%目的 探讨血浆D-二聚体及纤维蛋白原(fibrinogen,FIB)在非小细胞肺癌患者手术前、后监测中的应用价值.方法 测定254例非小细胞肺癌患者和52例肺部良性肿瘤患者血浆D-二聚体及FIB水平,对其术后D-二聚体及FIB变化进行随访监测.结果 非小细胞肺癌组

  7. The plasma D-dimer levels and their clinical significance in liver cirrhosis patients with portal vein thrombosis%肝硬化门静脉血栓患者血浆D-二聚体水平及其临床意义

    Institute of Scientific and Technical Information of China (English)

    姜佳丽; 展玉涛; 李莉

    2012-01-01

    Objective To investigate the plasma D-dimer levels and their clinical significance in liver cirrhosis (LC) patients with portal vein thrombosis (PVT) .Methods 77 patients with LC were selected and 31 had PVT, and 46 had not.The PVT was diagnosed by CT scan and the D-dimer levels were detected.Results The plasma D-dimer levels in patients with PVT were significantly higher than that in without PVT (l.2±0.5 mg/1 vs. 0.6±0.4mg/l;P<0.0l) ;The plasma D-dimer level in PVT patients with severe esophageal varices group (l.3±0.5mg/l) was higher significantly than that in patients with mild esophageal varices group (0.9±0.5mg/l,P<0.05) ;The plasma D-dimer level in patients with gastrointestinal bleeding (1.5±0.5mg/l) was higher significantly than that in patients without gastrointestinal bleeding (0.8±0.4mg/LP<0.0l) ; The plasma D-dimer level in death group (l.318±0.512mg/l) was higher significantly than in survived group (1.0±0.4mg/l,P<0.01).Conclusion Plasma D-dimer level increases in patients with LC and might prompt the PVT formation.%目的 探讨肝硬化门静脉血栓(PVT)患者血浆D-二聚体水平及其临床意义.方法 在77例肝硬化患者中,PVT形成患者31例,无血栓形成患者46例,依据螺旋CT检查诊断PVT,采用乳胶凝集法检测血浆D-二聚体水平.结果 血栓组和无血栓组患者血浆D-二聚体水平分别为1.2±0.5 mg/l和0.6±0.4mg/l(P<0.01);血栓组伴中重度食管静脉曲张患者血浆D-二聚体水平(1.3±0.5mg/l)显著高于轻度食管静脉曲张患者(0.9±0.5mg/l,P<0.05);血栓形成伴消化道出血和死亡患者血浆D- 二聚体水平显著高于无出血和生存患者(P<0.01).结论 肝硬化患者血浆D-二聚体水平升高可能与PVT形成有关,并严重影响预后.

  8. Avaliação do desempenho diagnóstico e do valor de corte para o índice de respiração rápida e superficial na predição do insucesso da extubação Evaluation of the diagnostic performance and cut-off value for the rapid shallow breathing index in predicting extubation failure

    Directory of Open Access Journals (Sweden)

    Aline Roberta Danaga

    2009-06-01

    Full Text Available OBJETIVO: Avaliar o desempenho diagnóstico do índice de respiração rápida e superficial (IRRS na predição do insucesso da extubação de pacientes adultos em terapia intensiva e verificar a adequação do valor de corte clássico para esse índice. MÉTODOS: Estudo prospectivo realizado na unidade de terapia intensiva de adultos do Hospital das Clínicas da Faculdade de Medicina de Botucatu, através da avaliação do IRRS em 73 pacientes consecutivos considerados clinicamente prontos para extubação. RESULTADOS: O IRRS com valor de corte clássico (105 ciclos/min/L apresentou sensibilidade de 20% e especificidade de 95% (soma = 115%. A análise da curva receiver operator characteristic (ROC demonstrou melhor valor de corte (76,5 ciclos/min/L, o qual forneceu sensibilidade de 66% e especificidade de 74% (soma = 140%, e a área sob a curva ROC para o IRRS foi de 0,78. CONCLUSÕES: O valor de corte clássico do IRRS se mostrou inadequado nesta casuística, prevendo apenas 20% dos pacientes com falha na extubação. A obtenção do novo valor de corte permitiu um acréscimo substancial de sensibilidade, com aceitável redução da especificidade. O valor da área sob a curva ROC indicou satisfatório poder discriminativo do índice, justificando a validação de sua aplicação.OBJECTIVE: To evaluate the diagnostic performance of the rapid shallow breathing index (RSBI in predicting extubation failure among adult patients in the intensive care unit and to determine the appropriateness of the classical RSBI cut-off value. METHODS: This was a prospective study conducted in the adult intensive care unit of the Botucatu School of Medicine Hospital das Clínicas. The RSBI was evaluated in 73 consecutive patients considered clinically ready for extubation. RESULTS: The classical RSBI cut-off value (105 breaths/min/L presented a sensitivity of 20% and a specificity of 95% (sum = 115%. Analysis of the receiver operator characteristic (ROC curve

  9. A cut-off low in southern South America: dynamic and thermodynamic processes Um caso de vórtice ciclonico desprendido em altos níveis no sul da América do Sul: processos dinâmicos e termodinâmicos

    Directory of Open Access Journals (Sweden)

    Alejandro Anibal Godoy

    2011-12-01

    Full Text Available The dynamic and thermodynamic processes involved in the life cycle of a cutoff low occurred in March 2007 are studied. These processes are analyzed using the vorticity and thermodynamic equations and a set of analyses generated with the BRAMS model. The main processes that explain the segregation of the subtropical part of the trough are the horizontal advection of cyclonic vorticity at high levels and warm horizontal advection at middle levels, both over the Pacific Ocean extending south to the Patagonia region, building the ridge located upstream of the trough. Increased intensity of the upper level low pressure system is mainly explained by intensification of the ridges down and upstream. The divergence effect is opposed to the horizontal advection of vorticity which explains the stagnation of the cut-off low windward of the Andes. The decay stage is dominated by warm vertical advection. Assuming the conservation of potential vorticity the analysis of parcel trajectories , allowed detecting the entrance of stratospheric air to middle levels of the lower troposphere around the cut-off low.Neste trabalho foram estudados os processos dinâmicos e termodinâmicos que envolvem o ciclo de vida de um caso de vórtice ciclônico desprendido em altos níveis, que ocorreu em março de 2007. Tais processos são analisados através dos termos das equações de vorticidade e termodinâmica usando um conjunto de análises geradas com o modelo BRAMS. Os principais processos que explicam o desprendimento da parte subtropical de um cavado são a advecção horizontal da vorticidade anticiclonica em níveis altos e a advecção horizontal de ar quente em níveis médios, ambas sobre o sul do Oceano Pacífico e estendendo-se em direção a região Patagônica, aprofundando a crista localizada corrente acima do cavado. A continuidade do aprofundamento desta crista, juntamente com a crista localizada corrente abaixo do cavado são as responsáveis da intensifica

  10. 联检NSE、CYFRA21-1、D-二聚体、Fib在肺癌患者中的临床意义%Clinical significance of the combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen for the patients with lung cancer

    Institute of Scientific and Technical Information of China (English)

    谢颖; 贾张军; 张云生

    2014-01-01

    Objective To discuss the clinical significance of the combined determination of NSE,CYFRA21-1, D-Dimer, Fibrinogen for lung cancer patients. Methods The levels of serum NSE and CYFRA21-1 were detected by electrochemical analysis in 256 lung cancer patients, 200 patients with benign lung diseases and 200 health subjects. The levels of plasma D-Dimer and Fibrinogen were detected by immunoturbidimetric assays. The relationship of NSE, CYFRA21-1, D-Dimer and Fibrinogen levels with the clinical stages of lung cancer was analyzed by statistics. Results The levels of NSE, CYFRA21-1, D-Dimer and Fibrinogen in patients with lung cancer were significantly higher than those in patients with benign lung diseases and healthy controls(PCYFRA21-1 > D-Dimer > Fibrinogen.CYFRA21-1 showed the highest sensitivity(69.0%) in squamous cellcarcinoma, and NSE showed the highest sensitivity(68.4%%) in smal celllung cancer. The combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen might significantly improve the sensitivity for the diagnosis of lung cancer. The combined determination of NSE,CYFRA21-1, D-Dimer, Fibrinogen showed the highest sensitivity(89.8%).NSE,CYFRA21-1, D-Dimer, Fibrinogen were positively related to the clinical stages of lung cancer. With the increasing of clinical stages, the levels of NSE,CYFRA21-1, D-Dimer, Fibrinogen in Ⅲ/Ⅳ stage were significantly higher than those in Ⅰ/Ⅱ stage(correlation coefficie nt(r)=0.315,0.425,0.669,0.523,). Conclusions The combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen has an important clinical significance in the clinical diagnosis, differentiation, monitor and clinical stage of lung cancer.%联合检测神经元特异烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)、D-二聚体(D-D)、Fib(纤维蛋白原),探讨其在肺癌患者中的临床意义。方法肺癌组(256例)、肺良性疾病组(200例)和正常对照组(200例)的血清NSE、CYFRA21-1水平采用电化学发光分析法检测,血

  11. 节段截桥局限漂浮技术治疗胸椎黄韧带骨化症%Segmental cut-off bridge and local floating technology for the treatment of ossification of ligamentum flavum in throracic spine

    Institute of Scientific and Technical Information of China (English)

    梁卫东; 张健; 盛伟斌

    2013-01-01

    Objective To explore the efficacy and safety of segmental cut-off bridge and local floating technology for the treatment of ossification of ligamentum flavum (OLF) in throracic spine.Methods Retrospective study was performed in 98 patients with thoracic OLF who under went operation.There was 56 males and 42 females with an average age of 45.8 (35-73) years.The average duration of onset was 17 (3-51) months.The main clinical symptoms were numbness and paraesthesia (n=90),lower limb weakness and walking trouble (n =46),positive pyramidal tract signs (n =33) and sphincter function obstacle (n =9).OLF was screened and diagnosed by radiology,magnetic resonance imaging (MRI),computed tomography (CT) or CT myelography (CTM).A total of 142 OLF nidus were spotted.The lesions involved single segment (n =32),double segments (n =56),three segments (n =6) and ≥ four segments (n =4).And the locations were at upper throracic segment (T1-4) (n =34),middle throracic segment (T5-8) (n =23) and lower throracic segment (T9-12) (n =42).The OLF nidus were removed by local floating technology off windowing at cephalic and caudal ends and a cut-off bridge at both sides of involved segments.Pre-and post-operative Japanese Orthopedic Association (JOA) scores and Epstein grades were recorded to evaluate the outcomes.Results The mean loss volume of blood was 320 ml and operative duration 155 min.All cases recovered independent activities.The mean follow-up period was 28 (13-48) months.The mean preoperative JOA score was 4.3 (1-8) points and the mean postoperative JOA score 9.7 (5-11) points.The recovery rate was 78.8%.According to Epstein grade,the excellent and good rate was 86.7%.Conclusion As a common cause of thoracic spinal cord compression,OLF should be operated as early as possible.Based upon clinical and imaging findings,the application of segmental cut-off bridge and local floating technology is both safe and efficacious in the treatment of OLF in throracic spine.%目的 探

  12. Value of serum D-dimer levels to the elderly patients with pulmonary infection in the emergency%急诊80岁以上老年肺炎患者D-二聚体检测的意义

    Institute of Scientific and Technical Information of China (English)

    周卫华; 金东生; 朱旖; 李晓红

    2014-01-01

    Objective To investigate the relationship of serum D-dimer(D-D) levels with severity of pulmonary infection in the elderly patients over 80 years old in emergency.Methods The data of 143 cases (older than 80 years old) of pulmonary infection from December 2012 to December 2013 in emergency were retrospectively reviewed.The patients were assigned to the following pneumonia subgroups:segmental pneumonia,lobar pneumonia,and multilobar pneumonia,according to radiologic extension.They were divided into complication group and non-complication group.Results The serum D-D levels in the three subgroups were (295.24±49.11) ng/ml,(868.42 ± 941.11) ng/ml,(1706.67 ± 1210.44) ng/ml,respectively.There were significant difference between three groups(P<0.01).The serum level of D-D in segmental pneumonia group was significantly lower than that in lobar pneumonia group and multilobar pneumonia group (P<0.05).Serum D-D levels in complication group and non-complication group were (1226.78 ± 1173.83) ng/ml and (310.56± 361.30) ng/ml,and there was significant difference between the two groups (P<0.05).Conclusions The serum D-D level is associated with the severity of pneumonia in the elderly patients,and D-D could be used as an indicator for disease status of the elderly patients with pulmonary infection in emergency.%目的 研究≥80岁老年肺炎急诊患者血清D-二-聚体水平与病情严重程度的关系,探讨急诊检测D-二聚体的意义. 方法 回顾分析2012年12月至2013年12月我院急诊≥80岁老年肺炎患者血清D-二聚体水平,按照肺部影像改变范围分3组,单肺段肺炎组、单肺叶组和多肺叶肺炎组;按基础合并症分3组:无合并症组、单种合并症组、多种合并症组,在亚组内进行D-二聚体水平比较分析. 结果 单肺段肺炎组与单肺叶组和多肺叶组比较D-二聚体水平明显较低,差异有统计学意义(P<0.01);有基础合并症组较无合并症组D-二聚体水平增

  13. Value and Signiifcance of Antithrombin III, D-dimer and Platelet Detection for Sepsis in Children%抗凝血酶Ⅲ、D-二聚体和血小板检测在儿童脓毒症中的价值意义

    Institute of Scientific and Technical Information of China (English)

    程文文; 仇丽霞

    2016-01-01

    Objective to analyze value and significance of Antithrombin III, D-dimer and platelet detection for sepsis in children. Methods choose 40 cases sepsis patients treated in our hospital and 40 cases healthy checkup children as observation objects, admission time was from June 2014 to August 2015, healthy children were treated as control group, and sepsis children as experimental group, exam antithrombin III, D-dimer and platelet and observe index difference between healthy and sepsis children.Results examination result difference of antithrombin III, D-dimer and platelet between control healthy children and experimental sepsis group showed statistical significance (P< 0.05).Conclusion examination of antithrombin III, D-dimer and platelet for sepsis children has great value, which is worthy of clinical promotion.%目的:分析抗凝血酶Ⅲ、D-二聚体和血小板检测在儿童脓毒症中的价值及意义。方法选择我院收治的40例脓毒症患儿及40例健康体检儿童作为本次观察对象,收治时间为2014年6月至2015年8月,将健康体检儿童作为对照组,将脓毒症患儿作为实验组,检测抗凝血酶Ⅲ、D-二聚体和血小板,观察健康体检儿童及脓毒症患儿之间检测指标的差异。结果对照组健康体检儿童及实验组脓毒症患儿之间对比的抗凝血酶Ⅲ、D-二聚体和血小板检测结果均存在显著差异(P<0.05),统计学有意义。结论针对儿童脓毒症患儿实施抗凝血酶Ⅲ、D-二聚体和血小板检测的价值意义较大,值得临床推广。

  14. 先天性心脏病患儿术前充血性心力衰竭年龄分层后血浆氨基末端B型脑利钠肽前体诊断界值的研究%Cut-off values of amino-terminal pro-B-type natriuretic peptide for the diagnosis of chronic heart failure in children of age stratification with congenital heart disease prior to heart surgery

    Institute of Scientific and Technical Information of China (English)

    林春旺; 曾祥林; 孟秀会; 江少虎; 欧阳辉

    2013-01-01

    目的 通过检测先天性心脏病(congenital heart disease,CHD)患儿在行心脏手术前血浆中的氨基末端B型脑利钠肽前体(amino-terminal pro-B-type natriuretic peptide,NT-proBNP)血浆浓度,绘制ROC曲线分析其敏感度、特异度及约登指数,探讨0~5岁经年龄分层前后充血性心力衰竭(congestiveheart failure,CHF)患儿血浆NT-proBNP诊断界值.方法 测定2011年1月至2013年1月收治的100例CHD术前患儿(试验组)及100例正常儿童(对照组)血浆NT-proBNP,合并CHF的CHD患儿(CHF组)经年龄分层又分为0~1岁组、~3岁组和~5岁组,探讨各自的NT-proBNP诊断CHF的界值.结果 100例CHD患儿中,34例符合改良Ross心力衰竭诊断标准,试验组在年龄分层前按照ROC曲线选取的NT-proBNP诊断CHF界值为502 ng/L,经年龄分层后0~1岁组、~3岁组、~5岁组的NT-proBNP诊断CHF界值分别为552 ng/L、449ng/L、349 ng/L.结论 该研究结果显示,合并CHF的CHD术前患儿经年龄分层后0~1岁组、~3岁组、~5岁组的NT-proBNP诊断CHF界值分别为552 ng/L、449ng/L、349 ng/L.%Objective To detect the plasma amino-terminal pro-B-type natriuretic peptide (NT-ProBNP) of children with congenital heart disease(CHD) prior to heart surgery,to analysize its sensitivity,specificity and Youden index by receiver operating characteristic(ROC) curve,to explore the cut-off values of plasma NTProBNP for the diagnosis of congestive heart failure(CHF) in children under 5 years old before and after age stratification.Method The plasma NT-proBNP was detected for 100 children with CHD prior to heart surgery (experimental group) and 100 normal children(control group) between January 2011 to January 2013.Age stratification(0 ~ 1 year group,~3 years group and ~ 5 year group) was conducted in children with CHF younger than 5 years old to explore the cut-off values of plasma NT-ProBNP for the diagnosis of CHF.Results The NT-proBNP of 34 patients with CHF(n =100) was in

  15. On the comparison of the polarisation behaviour of exchange-biased AF/F NiMn/Fe{sub 37}Co{sub 48}Hf{sub 15} bi-layer and multi-layer films with increased ferromagnetic cut-off frequencies

    Energy Technology Data Exchange (ETDEWEB)

    Seemann, K., E-mail: klaus.seemann@kit.edu [Karlsruhe Institute of Technology KIT (Campus North), Institute for Applied Materials, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Leiste, H.; Krueger, K. [Karlsruhe Institute of Technology KIT (Campus North), Institute for Applied Materials, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany)

    2012-03-15

    Antiferromagnetic/ferromagnetic (AF/F) NiMn/Fe{sub 37}Co{sub 48}Hf{sub 15} films were investigated with respect to their exchange bias, in-plane unidirectional anisotropy, polarisation and high frequency behaviour. After deposition, carried out by r.f. magnetron sputtering, the films were post-annealed for 4 h at 300 Degree-Sign C in a static magnetic field, in order to induce exchange-bias, which results in a unidirectional anisotropy. Dependent on the presence of a bi-layer or multi-layer sandwich structure the films show a different exchange-bias field-ferromagnetic inter-layer thickness behaviour with exchange-bias fields {mu}{sub 0} Low-Asterisk H{sub eb} between 2 and 10 mT. The in-plane uniaxial (single film) or unidirectional anisotropy fields {mu}{sub 0}*H{sub UF} were between 4 and 18 mT. This results in a significant increase of the cut-off frequency in the GHz range in comparison to a single Fe{sub 37}Co{sub 48}Hf{sub 15} film, which is shown by frequency-dependent permeability plots. High damping in the imaginary part of the permeability, i.e., high resonance line broadening could be observed for films with high coercivity {mu}{sub 0}*H{sub c} of around 7 mT in the easy axis of magnetisation. - Highlights: Black-Right-Pointing-Pointer Static and dynamic properties of NiMn/Fe{sub 37}Co{sub 48}Hf{sub 15} bi- and multi-layer films. Black-Right-Pointing-Pointer Theoretic analysis of the H{sub eb}- field difference of bi- and multi-layer films. Black-Right-Pointing-Pointer Two-stage magnetic process in the polarisation curves of the AF/F multi-layers. Black-Right-Pointing-Pointer Damping at the ferromagnetic permeability resonance state of AF/F multi-layers. Black-Right-Pointing-Pointer Derivation of the ferromagnetic resonance of AF/F multi-layer films.

  16. Annual Adjustment Factors

    Data.gov (United States)

    Department of Housing and Urban Development — The Department of Housing and Urban Development establishes the rent adjustment factors - called Annual Adjustment Factors (AAFs) - on the basis of Consumer Price...

  17. 临床预测评分与D-二聚体结合诊断肺动脉栓塞的价值分析%The value analysis of clinical prediction score and D-dimer combination in the diagnosis of pulmona-ry embolism

    Institute of Scientific and Technical Information of China (English)

    王欣; 贾俐聪; 冯靖涛

    2016-01-01

    Objective In order to improve the early diagnosis of pulmonary embolism prediction ability,study and application of the receiver operating characteristic curve( ROC)analysis and comparison of plasma D-dimer,Wells score and modified Ge-neva score predictive value in diagnosis of pulmonary embolism. Method A retrospective analysis of 50 patients with suspected pulmonary embolism patients,plasma D-dimer,Wells score and modified Geneva score and spiral CT pulmonary angiography ( CTPA)examination. Application of ROC curve comparison of plasma D-dimer,Wells score and modified Geneva score predic-tive value in diagnosis of pulmonary embolism. Results The accuracy rate of plasma D-dimer in the diagnosis of pulmonary em-bolism was 80%,which was significantly higher than the Wells score(40%)and modified Geneva score(72%). The diagnostic accuracy rate of D-dimer detection and modified Geneva score combined was 94. 7%( 36/38 ),which was significantly higher than only using clinical prediction score diagnosis accuracy rate;Wells score and modified Geneva score was higher,the greater the probability of pulmonary embolism,predict the layered modified Geneva score was significantly higher than that in the accura-cy of Wells score,The plasma D-dimer,Wells score and modified Geneva score ROC curve prediction area pulmonary embolism respectively(0. 891 ± 0. 047),(0. 766 ± 0. 073)and(0. 815 ± 0. 070),statistically significant difference between groups( P﹤0. 05). 30 cases of plasma D-dimer detection with suspected pulmonary embolism negative,in the later follow-up(3 months) imaging were not found in pulmonary embolism. Conclusion The combination of plasma D-dimer and modified Geneva score is an effective means to predict early diagnosis of pulmonary embolism.%目的:为提高肺动脉栓塞早期预测诊断能力,探讨并应用受试者工作特征曲线( ROC)分析比较D-二聚体、Wells评分和改良Geneva评分对肺栓塞的预测诊断价

  18. Prognostic values of heart-type fatty acid-binding protein and D-dimer level in plasma in acute pulmonary embolism patients%心肌型脂肪酸结合蛋白联合血浆D-二聚体对肺栓塞预后评估的临床意义

    Institute of Scientific and Technical Information of China (English)

    陶琳; 杨毅

    2015-01-01

    ObjectiveTo evaluate the clinical value of heart-type fatty acid-binding protein (H-FABP) and D-dimer in assessing the prognosis of acute pulmonary embolism (APE). MethodsTotaly 120 APE patients were hospitalized from January 2011 to December 2014 and enroled in this study. The plasma H-FABP and D-dimer level were measured by enzyme-linked immunosorbent assay. The APE patients were divided three groups including low-risk, middle-risk and high-risk group by European heart association new guidelines. According to the clinical prognosis, the APE patients were divided into survival and death group. The H-FABP and D-dimer level in different groups and the relationship with the prognosis were assessed.ResultsWith the increased severity in patients, the H-FABP and D-dimer level were significantly elevated (P<0.05); the H-FABP and D-dimer level were significantly higher in death group as compared with survival group (P<0.05). The H-FABP and D-dimer level were positively correlated (r=0.693,P=0.000). ROC curves analysis results showed that the area under curve of H-FABP was 0.845 (95%CI: 0.752-0.918), and optimal operating point (OOP) was 8.65 µg/L, which had 81.24% sensitivity and 84.14% specificity; ACU of D-dimer was 0.832 (95%CI: 0.728-0.899), and OOP was 1.25 mg/L, which had 83.72% sensitivity and 82.65% specificity.Conclusion The H-FABP and D-dimer can effectively assess severity and prognosis of APE patients, meanwhile, it provide an objective basis for the clinical individual treatment and reducing the mortality rate of APE patients.%目的:探讨心肌型脂肪酸结合蛋白(H-FABP )联合血浆 D-二聚体在评价急性肺栓塞(APE)患者预后中的临床价值。方法选取本院2011年1月至2014年12月确诊的APE患者120例为研究对象,采用酶联免疫吸附法分别测定外周血H-FABP及D-二聚体浓度。根据病情严重程度将APE患者分为低危组、中危组及高危组;根据临床转归,分为存活组和死亡组

  19. D-Dimer combined with glycated hemoglobin level of cerebral small vessel disease condition prediction effect%D - D 二聚体水平联合糖化血红蛋白对脑小血管疾病病情的预测效果

    Institute of Scientific and Technical Information of China (English)

    周绍英; 伍辉; 王真艳; 刘连琴

    2015-01-01

    three sets. The high standards for the PI group of patients in which PI ﹥ 1. 5,this group included 49 patients. The group of patients with PI standard 1. 2≤PI≤1. 5 included 66 patients. Low PI group standards for PI ﹤ 1. 2 included 50 patients. The healthy control group included 50 cases. D - D- dimer,glycosylated hemoglobin,PI,blood pressure,weight,height and other basic information of all patients were detected and compared a-mong the four groups. The other indexes included D - D dimer blood samples,the difference of glycohemoglobin. Multivariate Logistic regression was used to determine the risk of cerebral small vessel disease,and analyze the relationship between glycated hemoglobin and D - dimer and cere-bral small vessel disease condition. Results The difference D - dimer and glycated hemoglobin content of the four groups of the study were statis-tically significant. Pairwise comparisons between groups were statistically difference. D - dimer,glycosylated hemoglobin were small risk factors for vascular disease. Pesrson correlation analysis showed that glycated hemoglobin levels and severity of cerebral small vessel disease of the disease was positively correlated( r = 0. 669,P = 0. 013). D - Dimer and severity of cerebral small vessel disease condition had a positive correlation( r =0. 683,P = 0. 010). Conclusion The severity of D - dimer levels and glycosylated hemoglobin content of cerebral small vessel disease had a positive correlation between clinically by D - Dimer levels and glycated hemoglobin,which can predict disease cerebral small vessel disease to a certain extent.

  20. Correlation of plasma D-dimer, T lymphocyte subsets, CRP level with Apgar score of neonates in pregnant women with pregnancy-induced hypertension during perinatal period%妊高征孕妇围生期血浆D-二聚体、T细胞亚群及CRP水平与胎儿Apgar评分的相关性

    Institute of Scientific and Technical Information of China (English)

    钟晓红

    2014-01-01

    Objective It is to explore the correlation of plasma D -dimer ( D-D) , T lymphocyte subsets , CRP level with Apgar score of neonates in pregnant women with pregnancy-induced hypertension ( PIH) during perinatal period .Methods 120 pregnant women with PIH were selected as observation group , and 60 healthy pregnant women were selected as control group . Plasma D-D, CD4 +and CD8 +T cell lymphocyte subsets and CRP level of the two groups were detected before and 3d after delivery , and Apgar scores of neonates were recorded after delivery .By applying Pearson correlation analysis , the correlation of plasma D-dimer, T lymphocyte subsets proportion , CRP level and Apgar score of neonates was analyzed .Besides, the correlation of D-dimer, CD4+/CD8 +, CRP index, and Apgar score of neonates was analyzed by multiple logistic regression analysis.Results There was no statistical difference in plasma D -D, CD4+/CD8 +and CRP before and 3d after delivery in control group (P>0.05), while observation group’s plasma D-D and CRP decreased (P<0.05), and CD4 +/CD8 +in-creased (P<0.05).By comparison, D-dimer, CRP, and CD4 +/CD8 +before and 3d after delivery in observation group were all higher than those in control group (P<0.05).By Pearson correlation, it showed that D -dimer, CD4 +/CD8+, CRP and Apgar score of neonates were both negative correlation with each other (P<0.05).By multiple logistic regression a-nalysis, D-dimer and CD4 +/CD8 +are independent forecast factors for Apgar score of neonates (OR=0.673, P=0.032;OR=0.543, P=0.026).Conclusion Plasma D-dimer, T lymphocyte subsets and CRP in pregnant women with PIH during perinatal period have clinical value for assessment of Apgar score of neonates .%目的:探讨妊娠高血压综合征孕妇围生期血浆D-二聚体( D-dimer )、T细胞亚群、C反应蛋白( CRP)与胎儿Apgar评分的相关性。方法选取妊高征孕妇120例设为观察组;另选取同期孕检的健康孕妇60例设为对照组。检测2

  1. 联合检测血清降钙素原、C反应蛋白、乳酸、D-二聚体水平在儿童脓毒症中的意义%Significance of combined detection of serum procalcitonin, C-reactive protein, lactic acid and D-dimer level in children with sepsis

    Institute of Scientific and Technical Information of China (English)

    陈晓锐; 彭俊旭; 郑华

    2016-01-01

    目的:探讨血清降钙素原、C反应蛋白、乳酸、D-二聚体水平在儿童脓毒症联合检测的意义。方法选取64例我院治疗的脓毒症,根据患儿病情情况,将脓毒症组分为一般脓毒症和重度脓毒症组,另选择32例健康儿童为正常对照组。于入院后1h内测定血清降钙素原、C反应蛋白、乳酸、D-二聚体水平。结果脓毒症患儿组血清降钙素原、C反应蛋白、乳酸、D-二聚体水平较正常儿童组明显升高,差异有统计学意义( P<0.01);重度脓毒组血清降钙素原、乳酸水平在诊断为脓毒症后的6 h、24 h、48 h比一般脓毒症组升高,差异有统计学意义(P<0.01),C反应蛋白水平在两组中比较差异无统计学意义(P>0.05);脓毒症组并发DIC者四项指标同时升高,且死亡组血清降钙素原、乳酸、D-二聚体水平比存活组更高,差异有统计学意义(P均<0.01)。结论在脓毒症患儿中联合检测血清降钙素原、C反应蛋白、乳酸、D-二聚体水平可能可以提高诊断早期脓毒症及判断病情严重程度及预后的水平。%Objective To explore the significance of combined detection of serum procalcitonin, C-reactive protein, lactic acid and D-dimer levels in children with sepsis.Methods 64 cases with sepsis according to their situation were divided into general sepsis and severe sepsis group, and 32 cases healthy children were selected as control group.Serum procalcitonin, C-reactive protein, lactic acid and D-dimer levels were detected within 1h after they were hospitalized.Results Serum procalcitonin, C-reactive protein, lactic acid and D-dimer levels in sepsis group were significantly higher (P0.05);All the four parameters in sepsis group complicated with DIC increased at the same time, and in death group, serum procalcitonin, lactic acid and D-dimer levels were significantly higher than the survival group ( P <0.01 ) . Conclusions

  2. 儿童单纯性肥胖危险因素分析及与血浆D-二聚体的相关性%Analysis of risk factors of childhood simple obesity and its relationship with plasma D-dimer

    Institute of Scientific and Technical Information of China (English)

    张晓杰; 刘静; 孙利伟; 田玉玲

    2012-01-01

    目的 探讨儿童单纯性肥胖的危险因素以及血浆D-二聚体与肥胖的相关性.方法 采用问卷调查和体格测量的方法调查2006年1月 - 2010年12月就诊的单纯性肥胖儿童530例,其中102例测定血浆D-二聚体.同时选取120例性别、年龄、地区分布相匹配的健康儿童作对照,其中89例测定血浆D-二聚体.结果 肥胖儿童出生体质量、其父母平均体质指数(BMI)均较对照组明显增高,差异有统计学意义(P均< 0.01);肥胖儿童较正常对照儿童每日运动时间少,睡眠时间和看电视时间多,差异均有统计学意义(P均< 0.01);儿童肥胖与饮食有关;肥胖儿童有心血管病家族史的比例明显高于对照组,血浆D-二聚体含量(0.85 ± 0.31)mg/L亦较对照组(0.30 ± 0.11)mg/L明显增高,差异均有统计学意义(P < 0.001).结论 儿童肥胖是遗传因素和环境因素共同作用的结果,血浆D-二聚体与儿童单纯性肥胖具有相关性.%Objective To investigate the risk factors of children simple obesity and the association of plasma D-dimer and children simple obesity. Methods The height and body weight of 530 outpatients with simple obesity were measured and questionnaire survey was processed from January 2006 to December 2010. The plasma D-dimer was tested in 102 children of them. Meanwhile, 120 healthy children were selected as control with matched gender, age and region. The plasma D-dimer was also measured. Results The birth weight and the mean parents BMI of obese children were significantly higher than those of control group (P < 0.01). Compared with the control group, obese children daily exercised less time but spent more time on sleeping and watching TV (all P < 0.01). Children obesity was diet related, and the percentage of family history of cardiovascular disease and the levels of D-dimer in obese children were significantly higher than those in control group (P < 0.001). Conclusions Obesity in children is

  3. 茂名地区中老年人血浆D-二聚体参考区间的建立及应用评估%The plasma D-Dimer reference range establishment and the evaluation in the middle-aged and elderly of Maoming Area

    Institute of Scientific and Technical Information of China (English)

    冯程娟; 苏东梅; 陈和勇; 杨松娣

    2015-01-01

    目的:建立并了解中老年人血浆D-二聚体的参考区间,提高血浆D-二聚体在中老年人患者中的应用价值。方法选取2012年10月~2014年11月广州中医药大学附属茂名市中医院内科健康体检的50岁以上中老年人685名(男411名,女274名),发生肺栓塞5例,静脉血栓症4例及健康青年对照组164名。将50岁以上的中老年人按男、女及年龄分为50~0.05)。D-二聚体参考区间随年龄而逐渐升高,各年龄段均高于健康人群的疾病界定值(0.5 mg/L)。采用上述参考区间评估9例患者的D-二聚体水平,均为阳性结果。结论本研究初步建立并评估了茂名地区50岁以上中老年人血浆D-二聚体参考区间,提高了D-二聚体检测在中老年人群中的应用价值。%Objective To establish and understand the plasmatic D-Dimer reference range in the middle-aged and el-derly, and improve the application value of D-Dimer in the middle-aged and elderly. Methods From Octorber 2012 to Novenber 2014, selected 685 old people aged over 50 years (male 411 cases, female 274 cases) who had joined the medicine health examination in Department of Internal Medicine, Maoming Traditional Chinese Medical Hospital Affili-ated to Guangzhou University of Traditional Chinese Medicine, and 5 patients with venous, 4 patients with venous throm-bosis and 164 healthy youths (as the control group). The elderly aged over 50 years were divided into 50-0.05). With the age increasing, the diseased value of definition of all ages were higher than those in healthy population (0.5 mg/L). Using the reference interval to evaluate the D-Dimer level of 9 patients, the results were positive. Conclusion This study es-tablishes and evaluates the plasma D-Dimer reference interval among the elderly aged over 50 years old in Maoming Area, and improves the application value of D-Dimer in the middle-aged and elderly.

  4. 依达拉奉对急性脑梗死患者超敏C-反应蛋白及D-二聚体的影响%Effects of Edaravone on the levels of hs-CRP and D-dimer in Patients with Acute Cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    杜金明; 闫宗廷

    2010-01-01

    目的 探讨依达拉奉对急性脑梗死患者血清超敏C-反应蛋白(hs-CRP)、D-二聚体的影响及临床疗效.方法 86例急性脑梗死患者随机分为两组,即常规治疗组和治疗组,治疗组在常规治疗基础上给予依达拉奉30 mg每天2次静脉点滴,连用14 d.治疗前后测定血清hs-CRP、D-二聚体的变化并用中国卒中量表(Chinese stroke scale,CSS)及巴氏指数(Barthel index,BI)评定.结果 两组患者hs-CRP和D-二聚体均下降,治疗组明显低于常规治疗组(P<0.05).治疗后两组CSS及BI评分指数较治疗前均明显增加,治疗组评分高于常规治疗组(P<0.05).结论 依达拉奉可降低急性脑梗死患者hs-CRP、D-二聚体的水平,有益于患者神经功能的恢复.%Objective To investigate the effects of edaravone on the levels of high sensitivity C-reactive protein(hs-CRP) and D-dimer in patients with acute ischemic cerebral infarction. Methods A total of 86 patients with acute ischemic cerebral infarction were randomly divided and assigned into therapy group and control group. The control group was given a routine treatment of acute ischemic stroke. The therapy group was treated with edaravone in addition to the routine treatment. hs-CRP and D-dimer were measured before and after treatment. Barthel index(BI) and Chinese stroke Scale(CSS) of two groups were assessed before treatment and after treatment. Results The levels of hs-CRP and D-dimer were deceased after treatment. After the start of edaravone ,the levels of hs-CRP and D-dimer of therapy group were significantly lower than those of control group(P <0.05). The scores of CSS and BI of two groups improved after treatment,and scores of CSS and BI of the therapy group were better than those of the control group(P< 0.05). Conclusion Edaravone could decrease the levels of hs-CRP and D-dimer and is beneficial to improve neurofunctional recovery.

  5. 困难气道危险因素Logistic回归分析及身高甲颏距离比最佳临界点%Logistic regression analysis of the risk factors for difficult airway and the cut-off value of height-to-thyromental distance ratio

    Institute of Scientific and Technical Information of China (English)

    靳皓; 陈萍

    2015-01-01

    Objective To analyze the risk factors for difficult airway in laryngoscopy and mask ventilation. Methods A total of 300 patients receiving general anesthesia with tracheal intubation were examined preoperatively for height, thyromental and sternomental distance (TMD), range of neck movement, inter-incisor distance, and modified Mallampati class. Intubation Difficult Score was used to identify a difficult laryngoscopy. Difficult airway was defined as either difficult laryngoscopy or difficult mask ventilation. The association between the airway characteristics and difficult airway was analyzed by logistic regression analysis, and the cut-off values for the height-to-TMD ratio was determined by the ROC curve. Results and Conclusion Eight airway characteristics were identified to contribute to a difficult airway, including (OR [95%CI]) the height-to-TMD ratio (3.58[1.95-8.46]), modified Mallampati class (3.34 [1.82-7.14]), BMI (3.07 [1.64-6.69]), history of a previous difficult airway (2.79 [1.28-5.25]), a thick neck (2.15 [1.04-4.37]), range of neck movement (1.98 [0.96-3.89]), sternomental and angulus mandibulae distance (1.46 [0.67-3.04]), and inter-incisor distance (1.01 [0.49-2.54]). The optimal cut-off value for the height-to-TMD ratio was 22.8 for predicting a difficult airway.%目的:根据常用气道评估指标探究困难气道的危险因素。方法选择300例拟行气管插管全麻的患者,术前测量身高、甲颏距离、颈部后仰度、张口度、改良Mallampati分级等气道评估指标。以困难插管评分>5分为困难气管插管,结合困难面罩通气共同定义困难气道。通过logistic回归分析评估各项指标与困难气道相关性,并通过ROC曲线计算受试人群身高甲颏距离比最佳临界点。结果共8项相关因素按相对危险度估计值(OR)由大到小依次为:身高甲颏距离比3.58(1.95~8.46)、改良Mallampati分级3.34(1.82~7.14)、体质量指数3.07(1.64~6.69

  6. Covariate Adjustment in Receiver Operating Characteristic Curve Analysis for PSA in Diagnosis of Prostate Cancer

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    Emre DEMIR

    2016-10-01

    Full Text Available Objective: Markers which are used for classification into two groups, such as patient / healthy, benign/malignant or prediction of optimal cut off value for diagnostic test and evaluating the performance of diagnostic tests is evaluated by Receiver Operating Characteristic (ROC curve in the diagnostic test researches. In classification accuracy research, some variables such as gender and age, commonly is not similar in groups. In these cases, covariates should be considered to estimate in the area under ROC and covariate adjustment for ROC should be performed. This study aims to introduce methods in the literature for the effect of covariate adjustment and to present an application with sample from the health field. Material and Methods: In the study, we introduced methods used in the literatüre for covariate adjustment and prediction of the area under ROC curves as well as an application with data from the field of urology. In this study, 105 PSA (prostate specific antigen measurements were taken in order to examine the covariate effect for the age variable and to assess the diagnostic performance of PSA measurements with regard to pathologic methods. Results: Covariate effect were found statistically significant with 0.733 parameter estimation of the age in ROC curves analysis with PSA data (p<0.001. According to the methods (Non-parametric (empirical, non-parametric (normal, semi-parametric (empirical, parametric (normal that estimates of the area under ROC curves which is obtained without covariate effect were found 0.708, 0.629, 0.709 and 0.628, respectively, by using PSA measurements. Area under the curve that obtained by covariate adjustment were significantly lower as compared to the traditional ROC with estimation 0.580, 0.577, 0.582 and 0.579. Conclusion: Area under the ROC curves should be estimated with adjustment according to the covariates that could affect the markers value of diagnostic tests performed in concert with matching

  7. D-二聚体和肌钙蛋白I比值在致命性胸痛病因诊断中的应用%Application of the ratio of D-dimer and Troponin I in etiological diagnosis of acute chest pain

    Institute of Scientific and Technical Information of China (English)

    夏武杰; 杨鹏麟

    2016-01-01

    Objective To investigate the value of plasma d- dimer, troponin I and their ratio in etiological diagnosis of acute chest pain. Methods The data of 786 patients (534 male, 252 female, aged from 28 to 93 years) admission for acute chest pain and diagnosed as either acute myocardial infarction (AMI), acute pulmonary embolism (APE) or acute aorta dissection (AAD) were analyzed retrospectively. AMI was divided into ST segment elevation and non- ST segment elevation myocardial infarciton (STEMI, NSTEMI). Serum d- dimer, troponin I and their ratio were analyzed. The receiver operating characteristic curve (ROC curve) was performed to determine the value of d- dimer, troponin I, the ratio of d- dimer to troponin I (Rd) and troponin I to d- dimer (Rc) in the differential diagnosis of STEMI, NSTEMI, APE and AAD. Results D- dimer was significantly higher in AAD(11.13μg/ml) and APE groups(3.92μg/ml)than STEMI(0.38μg/ml) and NSTEMI groups(0.34μg/ml)(al P<0.05). There was significant difference between ADD and APE groups(P<0.05) and no significant difference between STEMI and NSTEMI groups. Troponin I was significantly higher in STEMI group(5.000ng/ml) than in NSTEMI group (3.035 ng/ml)(P<0.05). Both of them were significantly higher than 0.030 ng/ml in APE and AAD groups (al P<0.05). From STEMI to NSTEMI to APE to AAD, Rc was decreasing and Rd was increasing. There was significant difference between any two groups (al P<0.05). The ROC curve showed that Rc was superior to troponin I and Rd superior to d- dimer in the differential diagnosis of these diseases. Conclusion The ratios of D- dimmer to troponin I and troponin I to D- dimmer are benefit to improve the sensitivity and specificity of each parameter in the diagnosis of acute chest pain.%目的:探讨D-二聚体、肌钙蛋白I及其比值在鉴别致命性胸痛病因诊断中的应用。方法因胸痛或胸闷至我院急诊确诊为心肌梗死、肺栓塞、主动脉夹层的患者786例,男性534

  8. 儿童过敏性紫癜外周血血小板参数及D-二聚体水平变化%Analysis of Peripheral Platelet Parameters and D-dimer in Children with Henoch-Sch(o)nlein Purpura

    Institute of Scientific and Technical Information of China (English)

    孙燕; 张惠君; 常红; 张秋业; 陈玉秀

    2013-01-01

    目的:探讨外周血血小板参数及D-二聚体水平在儿童过敏性紫癜(Henoch-Schonlein purpura,HSP)的变化及临床意义.方法:选择2010年6月至2012年5月间青岛大学医学院附属医院儿科住院过敏性紫癜患儿137例为研究对象,儿童保健科健康查体儿童50例为对照组.血小板参数包括血小板计数(PLT)、平均血小板体积(MPV)、血小板压积(PCT)、血小板体积分布宽度(PDW),采用XE-2100全血细胞分析仪、电阻抗法检测;血浆D-二聚体采用胶乳比浊法检测.结果:与对照组比较,HSP患儿急性期外周血PLT、PCT显著升高(P<0.05),而MPV显著降低(P<0.05),PDW无显著差异(P>0.05);有无胃肠道出血HSP组间和有无肾脏受损HSP组间血小板参数并无显著性差异(p>0.05).84例(61.3%)HSP患儿急性期血浆D-二聚体水平增高,其绝对浓度(中位数)为435 ng/ml,显著高于正常水平(0-300 ng/ml);不同HSP临床表型组间血D-二聚体异常率和绝对浓度均无显著性差异(X2=2.75,P>0.05;H=3.37,P>0.05);合并胃肠道出血组与无消化道出血组比较HSP病儿血浆D-二聚体水平显著升高(Z=-2.691,P<0.05);合并肾损害与无肾损害组比较HSP病儿血浆D-二聚体水平显著降低(Z=-4.063,P<0.05).结论:HSP患儿急性期血液处于高凝及继发的纤溶状态,早期检测血小板参数及D-二聚体变化水平,指导临床诊断及临床用药.%Objective:To investigate the levels and clinical significance of peripheral platelet parameters and d-dimer in children with Henoch-Sch?nlein purpura (HSP).Methods:One hundred and thirty-seven patients diagnosed as HSP and fifty healthy children were enrolled.Platelet parameters,including platelet counts (PLT),mean platelet volume (MPV),platelet crit (PCT),platelet distribution width (PDW) were measured by resistance method using XE-2100 automatic blood count device.Plasma d-dimer was measured by latex turbidity.Results:Compared with that in

  9. Clinical Significance of B Type Natriuretic Peptide and D-dimer in Patients with Chronic Pulmonary Heart Disease Detection%B型脑钠肽和D-二聚体在慢性肺源性心脏病患者中检测的临床意义

    Institute of Scientific and Technical Information of China (English)

    郭春霞

    2013-01-01

    目的:探讨B型脑钠肽(BNP)和D-二聚体(D-dimer)在慢性肺源性心脏病(CPHD)患者中的水平变化,分析其临床意义。方法:用免疫比浊法测定单纯慢性阻塞性肺疾病(COPD)患者,慢性肺源性心脏病(CPHD)急性加重期和临床缓解期患者的血浆D-二聚体含量,同时用免疫荧光法检测各组患者的B型脑钠肽水平,用血气分析仪测定各组患者的pH值、动脉血氧压(PaO2)、动脉二氧化碳分压(PaCO2),观察比较各组BNP、D-dimer含量的差异和进行动脉血气分析。结果:慢性肺源性心脏病患者急性加重期和临床缓解期患者血浆D-二聚体含量分别为(2.74±0.87)μg/L、(2.09±0.77)μg/L,均较单纯性COPD组患者的(1.67±0.65)μg/L明显升高,差异均有统计学意义(P<0.05);CPHD急性加重期和临床缓解期患者BNP水平分别为(919.34±189.33)pg/mL、(213.60±31.74)pg/mL,较单纯性COPD组患者(37.30±12.74)pg/mL明显增高,各组比较差异均有统计学意义(P<0.01)。BNP、D-dimer含量与PaO2呈负相关,与PaCO2呈正相关(P<0.05)。结论:联合检测B型脑钠肽和D-二聚体水平变化对慢性肺源性心脏病患者病情变化、疗效监测及预后有重要的临床意义。%Objective:To study the B-type natriuretic peptide(BNP)and D- dimer(D-dimer)levels in patients with chronic pulmonary heart disease(CPHD)and analyze its clinical significance.Method:Plasma D-dimer content by nephelometry and B-type natriuretic peptide levels by immunofluorescence assay were detected in patients with simple chronic obstructive pulmonary disease(COPD),chronic pulmonary heart disease (CPHD)in acute exacerbation and remission respectively,pH value,PaO2 and PaCO2 were determined by blood gas analyzer.Differences of the content of BNP,the D-dimer levels and arterial blood gas analysis were observed and compared among the groups.Result:Plasma D-dimer

  10. Establishment of D-dimer reference intervals for pregnant women of 34 gestational weeks and its predictive value on postpartumhemorrhage%上海地区孕晚期血浆D-二聚体参考范围的建立及其预测产后出血的意义

    Institute of Scientific and Technical Information of China (English)

    蔡眉; 沈虹; 唐振华

    2015-01-01

    Objective: To establish reference intervals for D-dimer during the third trimester of pregnancy in Shang-hai women, and to analyze the factors influencing the D-dimer level for evaluating its clinical significance in postpartum hemorrhage. Methods: 6398 cases of healthy pregnant women (healthy group) of 34 weeks gestation aged 19 to 49 years from maternity department in our hospital were enrolled, they had received routine medical examination from January 2013 to July 2014. Immune turbidimetric method was used to detect the plasma D-dimer level in pregnant woman at 34 weeks gestation. Changes in D-dimer level were analyzed in 2 834 cases with obstetric risk factors (uterus anomaly, abnormal placenta, anemia, amniotic fluid anomalies, history of high blood pressure, diabetes, adverse pregnancy) (observed group) and in 347 cases of postpartum hemorrhage. Forty healthy non-pregnant women when not menstruating were enrolled as control group. Results:The median level of plasma D-dimer was 1.25 mg/L (95%CI:1.22-1.28) in 6 398 healthy pregnant women,and was 1.89 mg/L (95%CI:1.82-1.96) in 2 834 cases with obstetric risk factors. There was significant difference between the two groups (P0.05). D-dimer level was 0.30 mg/L(95%CI:0.22-0.38)in control group. Plasma D-dimer level had predictive value for postpartum hemorrhage in pregnant women with obstetric risk factors (OR=2.01, 95%CI:1.57-2.56), while had no predic-tive value for postpartum hemorrhage in healthy pregnant women. Conclusions: The 95% reference range for D-dimer in-tervals in healthy pregnant women at 34 weeks gestation is <3.05 mg/L, which is much higher than that in healthy non-pregnant women when not menstruating. D-dimer has predictive value for postpartum hemorrhage in pregnant women with obstetric risk factors.%目的:建立上海地区健康孕妇孕晚期(34孕周)血浆D-二聚体参考范围,对影响D-二聚体的相关因素进行统计分析,评价其在预测孕妇产后出血中的

  11. 腋窝皱襞小切口大汗腺剪除术根治腋臭334例疗效观察及围手术期护理%The Clinical Effect Observation and Perioperative Care of A Treatment Method, Cutting off Apocrine Sweat Gland Precisely with Minimally Invasive in Axillary Folds, for Bromhidrosis

    Institute of Scientific and Technical Information of China (English)

    张璃; 林孝华; 宣喧; 李智铭

    2011-01-01

    目的 观察腋窝皱襞小切口大汗腺剪除术根治腋臭的疗效,探讨其围手术期预防并发症的措施.方法 入选患者均沿腋毛区外1.0cm处标记手术区域,在腋窝中央皮肤皱褶处切口,长约1.5 ~2.0cm,沿皮下组织浅层分离术区皮肤组织,翻转皮瓣,剪除皮肤上脂肪组织、大汗腺及毛囊,修剪成仅含皮肤全层和真皮下血管网的超薄皮瓣,再缝合切口.结果 334例患者,共治疗668侧,均有效,痊愈412侧,显效256侧,无效0侧.围手术期出现皮下血肿21侧、局部皮肤坏死6侧、切口延迟愈合11侧、局部湿疹样皮炎12侧、水疱和血疱56侧,积极对症处理后,预后良好.结论 腋窝皱襞小切口大汗腺剪除术根治腋臭,疗效肯定,手术切口瘢痕不明显.围手术期应积极预防和处理各种并发症的发生.%Objective To discuss the clinical effect and perioperative care of a treatment method to cure the bromhidro-sis completely. Methods Mark the surgical area 1cm away around the armpit hair, draw the operative incision along the center of the area, which is around 1.5 ~2.0cm; Peel and turn off the skin, directly cut off the fat, apocrine sweat gland and hair follicle attached to the skin, and left full-thickness skin and subcutaneous vascular net only, then sew up the incision. Results Total 334 suffers, 668 sides were all cured properly. Of which 412 sides were healed completely. 256 sides gained remarkable curative effect. There were some complications incurred,such as subcutaneous hematoma(21 sides) ,local skin necrosis(6 sides) , delayed wound healing (11 sides ), local eczematous dermatitis ( 12 sides ), blister and blood blister ( 56 sides). In the end, they had also been appropriately cured. Conclusion This surgery is a useful treatment method for bromhidrosis, and the Scar is not obvious. However, it is also necessary to prevent and appropriately cure in case of any complications.

  12. Un caso de baja segregada en niveles altos en el sur de Sudamérica: descripción del ciclo de vida y su relación con la precipitación A case of high level cut-off cyclonic vortex over southern South America: description of the life cycle and its relation to precipitation

    Directory of Open Access Journals (Sweden)

    Alejandro Anibal Godoy

    2011-09-01

    Full Text Available En este trabajo se analiza el ciclo de vida de una baja segregada que afectó el sur de Sudamérica entre el 26 de Marzo y el 2 de Abril del 2007 y se explora la relación existente entre las diferentes etapas de este sistema y la precipitación ocurrida sobre la franja central de Argentina. Además se evalúa si otros procesos coadyuvaron para la ocurrencia de la misma. Las características más relevantes de este sistema son su larga duración y el lento desplazamiento, ya que entre el inicio y el fin de su vida se desplaza sólo 780 km, manteniéndose estacionario, durante las etapas de segregación y madurez, por más de 56 hs frente a la costa central chilena. Esta última característica favorece la formación de un sistema de baja presión sobre el noroeste de Argentina y la persistencia de una corriente en chorro en capas bajas del norte que se extiende desde el centro de Bolivia hasta norte argentino. La masa de aire con características tropicales conducida por esta configuración y la convergencia en niveles bajos favorecieron el desarrollo convectivo. La precipitación acumulada durante estas etapas, en algunas regiones del sur del litoral argentino, superó los 300 mm, produciendo extensas inundaciones en la región. Durante la etapa de decaimiento (96 hs de duración, el sistema se debilita a medida que se desplaza hacia el este y las precipitaciones afectaron las provincias del centro-oeste de Argentina donde la lluvia en 48 horas duplicó el promedio mensual de marzo.This paper describes the life cycle of a high level cut-off cyclonic vortex that affected southern South America between 26 March and 2 April 2007, and explores the relationship between the evolution stages of the system and the rainfall over central Argentina. The possibility of other processes contributing to rainfall is also analyzed. The most relevant characteristics of this system were its length and slow displacement: from its development to decay it moved only

  13. Determinação de escore e nota de corte do módulo de asma do International Study of Asthma and Allergies in Childhood para discriminação de adultos asmáticos em estudos epidemiológicos Determining the score and cut-off point that would identify asthmatic adults in epidemiological studies using the asthma module of the International Study of Asthma and Allergies in Childhood questionnaire

    Directory of Open Access Journals (Sweden)

    Elayne de Fátima Maçãira

    2005-12-01

    Full Text Available OBJETIVO: Validar o questionário padronizado escrito do International Study of Asthma and Allergies in Childhood, módulo sobre asma, para pesquisa de prevalência de asma, estabelecendo seu escore e a nota de corte para discriminação de adultos asmáticos. MÉTODOS: Entrevistamos pacientes ambulatoriais adultos, 40 asmáticos e 38 controles, pareados por sexo e idade, utilizando o módulo de asma do International Study of Asthma and Allergies in Childhood, composto por oito aspectos dicotômicos de asma. Determinamos o escore e a nota de corte para discriminação de asmáticos, definindo sua sensibilidade, especificidade e índice de Youden. Validamos o método em contraposição ao diagnóstico clínico e funcional. A reprodutibilidade das questões individuais foi testada por meio de reentrevistas de metade dos pacientes após algumas semanas. RESULTADOS: O escore variou de 0 a 14 pontos. Um escore = 5 pontos permitiu discriminar pacientes asmáticos (sensibilidade = 93%, especificidade = 100% e índice de Youden = 0,93. A maioria das questões apresentou boa reprodutibilidade, observada em reentrevista após 48,2 ± 11,1 dias (Kappa e Kappa ponderado variando de 0,43 a 1,00 para as questões individuais. CONCLUSÃO: A validação de uma nota de corte permite uma interpretação alternativa às informações fornecidas pelo módulo de asma do International Study of Asthma and Allergies in Childhood, levando em conta o conjunto das informações e não somente as respostas individuais de cada questão em estudos de prevalência de asma em adultos.OBJECTIVE: To validate, for use in asthma prevalence studies, the asthma module of the standardized written questionnaire developed for use in the International Study of Asthma and Allergies in Childhood, establishing the score and cut-off point that would identify asthmatic adults. METHODS: We interviewed 78 adult outpatients (40 adult asthmatics and 38 age-matched and gender-matched controls

  14. Benchmarking judgmentally adjusted forecasts

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans); L.P. de Bruijn (Bert)

    2015-01-01

    markdownabstractMany publicly available macroeconomic forecasts are judgmentally-adjusted model-based forecasts. In practice usually only a single final forecast is available, and not the underlying econometric model, nor are the size and reason for adjustment known. Hence, the relative weights give

  15. ADJUSTABLE CHIP HOLDER

    DEFF Research Database (Denmark)

    2009-01-01

    An adjustable microchip holder for holding a microchip is provided having a plurality of displaceable interconnection pads for connecting the connection holes of a microchip with one or more external devices or equipment. The adjustable microchip holder can fit different sizes of microchips...

  16. Clinical analysis of hemorheology, fibrinogen, D-dimer change in acute myocardial infarction%急性心肌梗死患者血液流变学、纤维蛋白原及D-二聚体的变化及其临床意义

    Institute of Scientific and Technical Information of China (English)

    苏华; 谢睿彬

    2012-01-01

    目的 观察急性心肌梗死(AMI)患者血液流变学、纤维蛋白原及D-二聚体的变化,探讨其临床价值.方法 选择我院收治的AMI患者44例作为AMI组,陈旧性心肌梗死(OMI)患者32作为OMI组,并选取同期门诊体检的健康人30例作为NC组.应用全自动血黏度测试仪测定受试对象血液流变学指标、纤维蛋白原(Fig)和D-二聚体水平,并对结果进行比较分析.结果 ①AMI组纤维蛋白原、D-二聚体水平较OMI组和NC组明显升高,差异有统计学意义(P<0.05),OMI组与NC组纤维蛋白原、D-二聚体水平比较差异无统计学意义(P>0.05);②AMI组与OMI组和NC组比较,血液流变学检查全血黏度低切、全血黏度中切、全血黏度高切、血浆黏度、红细胞压积、红细胞聚集指数、血沉均有不同程度的增高,差异有统计学意义(P<0.05),OMI组与NC组血液流变学指标比较差异无统计学意义(P>0.05).结论 急性心肌梗死患者血浆纤维蛋白原、D-二聚体水平明显升高,血液流变学指标发生明显改变,血液流变学及凝血机制异常在急性心肌梗死的发生和发展中起到重要作用,对于急性心肌梗死的诊断、疗效观察和预后判断有一定的临床价值.%Objective To observe hemorheology, fibrinogen, D-dimer change in acute myocardial infarction, and discuss its clinical value. Methods 44 patients with acute myocardial infarction (AMI) were selected as AMI group, 32 patients with old myocardial infarction (OMI) as the OMI group, and 30 cases of healthy people during the same period as the NC group. Hemorheology, fibrinogen (FIG), and the D-dimer levels were tested. Results FIG and D-dimer levels in AMI group were significantly increased compared with those in the OMI group or NC group (P< 0.05), but no difference of FIG and D-dimerbetween OMI group and NC group. Hemorheology check blood viscosity, low cut, cut in whole blood viscosity, high shear whole blood viscosity, plasma

  17. D-二聚体和凝血4项检测在孕妇产前检查中的临床价值分析%The clinical value analysis of D-Dimer and cruor detection in antenatal examination for pregnantwomen

    Institute of Scientific and Technical Information of China (English)

    邹庆红

    2013-01-01

    目的 探讨D二聚体和凝血4项检测在孕妇产前检查中的临床价值,提高妊娠高血压综合征孕妇分娩的安全性.方法 2011年8月~2012年5月,收集正常晚期妊娠妇女50例(晚孕正常组)、晚期妊娠合并妊娠高血压综合征妇女50例(晚孕妊高征组)和门诊体检非妊娠健康妇女50例(对照组),检测D-二聚体、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原(FIB).结果 晚孕妊高征组血清D-二聚体水平最高,对照组最低,差异有统计学意义(p<0.05).晚孕妊高征组PT和APTT水平最低,FIB水平最高,对照组PT和APTT水平最高,FIB水平最低,3组之间差异有统计学意义(P<0.05);3组间TT水平比较,差异无统计学意义(P>0.05).结论 正常妊娠妇女及妊娠高血压综合征妇女血液均处于高凝状态,产前检测D二聚体和凝血4项水平,有助于防止孕妇在分娩过程中发生血栓性疾病或弥漫性血管内凝血,减少产科意外的发生,可以作为产前筛查的主要指标.%Objective To investigate D-Dimer and cruor detection in antenatal examination for pregnant women, and improve the safety of pregnancy-induced hypertension pregnant woman. Methods From August 2011 to May 2012,researchers collected 50 cases of normal late pregnancy women (late pregnancy normal group) , 50 cases of iate pregnancy with pregnancy-induced hypertension women (late pregnancy with pregnancy-induced hypertension group) and 50 cases of non pregnancy healthy women (control group) , detected d-dimer, prothrombin time (PT) , activated part thromboplastin time (APTT) , thrombin time (TT) and fibrinogen ( FIB). Results The D-Dimer level of late pregnancy with pregnancy-induced hypertension group is the highest, and which of the control group is minimum, the differences indicated statistical significance (P 0. 05). Conclusion Normal pregnancy women and pregnancy-induced hypertension women are at a high cruor

  18. Clinical Significance of Brain Natriuretic Peptide(BNP),Cadiac TroponinⅠ(cTnⅠ),and D-dimer Detection in the Acute Pulmonary Embolism(APE)%血浆脑钠肽、肌钙蛋白Ⅰ联合D-二聚体检测对急性肺栓塞患者的临床意义

    Institute of Scientific and Technical Information of China (English)

    常慧

    2016-01-01

    Objective:To discuss the clinical significance of BNP, cTnⅠ and D-dimer detection in patients with APE.Method:76 patients with APE were divided into the massive APE group of 36 cases and the non massive APE group of 40 cases according to the embolization area, then the levels of BNP,cTnⅠ and D-dimer, right heart function and mortality of two groups were contrasted.Result:The levels of BNP and cTnⅠ in the massive APE group were significantly higher than the non massive APE group,the differences were statistically significant(P0.05).The incidence of right heart function failure and the fatality rate in the massive APE group was respectively 69.4% and 22.2%, significantly higher than 15.0% and 2.5% in the non massive PE group,the difference was statistically significant(P0.05)。大面积APE患者患右心功能不全发生率及病死率分别为69.4%与22.2%,均显著高于非大面积APE组的15.0%与2.5%,两组比较差异均有统计学意义(P<0.01)。结论:通过对APE患者血浆BNP、cTnⅠ水平的检测可对患者进行危险分层及预后评估,D-二聚体水平的检测可作为诊断APE的排除指标。

  19. 慢性阻塞性肺疾病急性加重期二氧化碳分压与D-二聚体的相关性研究%Study on the relationship between partial pressure of carbon dioxide and D-dimer in acute exacerbation of chronic obstructive pulmonary disease

    Institute of Scientific and Technical Information of China (English)

    王志安

    2014-01-01

    Objective To study the relationship between partial pressure of carbon dioxide(PaCO2) and D-dimer in acute exacerbation of chronic obstructive pulmonary disease (COPD),to provide a scientific basis and guidance for clinical treatment.Methods Forty-six COPD with acute exacerbation patients from January 2011 to January 2013 in our hospital were selected as observation objects,set as observation group,measured D-dimer and PaCO2 levels before and after treatment; forty-six healthy volunteers were selected as control group,measured D-dimer and PaCO2 level,and compared the levels between two groups.Results The observation group before treatment,two D-dimer,PaCO2 levels were (353±220.8) μg/L,(64.7±16.2) mmHg,control group D-two mer,PaCO2 levels were (73.6±21.1) μg/L,(40.3±4.5) mmHg,the observation group were significantly higher than those in control group,the difference between the two groups was significant (P <0.05) ;observation after treatment,D-two dimer,PaCO2 levels were (96.4 ± 24.8) μg/L,(46.3 ± 7.4) mmHg,the no significant difference with the control group (P >0.05).Conclusions Partial pressure of carbon dioxide and D-dimer levels in acute exacerbation of COPD was significantly higher inhealthy people,so the treatment of COPD patients,need to closely monitor patients with D-dimer and PaCO2 levels,to understand the progress of disease.%目的 探讨COPD患者在急性加重期PaCO2和D-二聚体的相关性,为临床治疗提供科学依据和指导.方法 选择2011年1月至2013年1月在鄂州市中心医院住院治疗的46例COPD急性加重期患者作为观察对象,设为观察组,测定治疗前后血浆D-二聚体、PaCO2水平;选择46例健康志愿者作为对照组,检测其血浆D-二聚体、PaCO2水平,比较两组血浆D-二聚体、PaCO2水平.结果 观察组治疗前D-二聚体、PaCO2水平分别为(353±220.8) μg/L、(64.7±16.2) mmHg,对照组D-二聚体、PaCO2水平分别为(73.6±21.1) μg/L、(40.3±4.5) mmHg,观察组均

  20. Change of pregnancy-associated protein A,urinary transferrin, D-dimer in patients with hypertension in pregnancy%妊娠相关蛋白 A、尿转铁蛋白、D-二聚体在妊娠期高血压病患者中的变化

    Institute of Scientific and Technical Information of China (English)

    张丽岩; 刘艳庚; 颜媛

    2015-01-01

    Objective To observe the significance of pregnancy-associated protein A (PAPP-A ), urinary transferrin,D-dimer in patients with hypertension in pregnancy and their correlation.Methods The study enrolled 120 patients with pregnancy-induced hypertension syndrome as pregnancy-induced hypertension group,at the same period, 30 healthy pregnant women with a full-term pregnancy were selected as the normal pregnancy group and 20 non-pregnant healthy women were as the healthy control group.The levels of PAPP-A,urinary transferrin and D-dimer were observed in pregnancy-induced hypertension group,normal pregnancy group and healthy control group,their levels and disease severity were detected in pregnancy-induced hypertension group and their relationship was explored. Results The levels of PAPP-A,urinary transferrin and D-dimer in pregnancy-induced hypertension group were significantly higher than those of normal pregnancy group and healthy control group (P < 0.01 ),and the levels in normal pregnancy group were also higher compared with those of healthy control group (P <0.01),as the severity of pregnancy-induced hypertension increased,the levels of PAPP-A,urinary transferrin and D-dimer increased (P <0.01).There were positive correlation between PAPP-A and urinary transferrin (r =0.593,P <0.01)or D-dimer (r=0.692,P <0.01),while there were positive correlation between D-dimer and urinary transferrin (r =0.622,P <0.01).Conclusion There are of great significances between the severity of pregnancy-induced hypertension and levels of PAPP-A,urinary transferrin,D-dimmer,and the items can be provided for the early diagnosis and treatment of pregnancy-induced hypertension.%目的:观察妊娠相关蛋白 A(PAPP-A)、尿转铁蛋白、D-二聚体在妊娠期高血压疾病患者检测中的意义及其相关性分析。方法选择在我院就诊的妊娠期高血压疾病患者120例,为妊娠期高血压疾病组,选择同期足月妊娠的健康孕妇30例,为正常妊娠组,选

  1. The Value of Clinical Examination of C-reactive Protein and D-dimer in Patients with Acute Leukemia and Infection%C反应蛋白和D-二聚体对急性白血病伴感染患者的临床检查价值

    Institute of Scientific and Technical Information of China (English)

    林少芳; 罗志敏

    2014-01-01

    目的:探讨C反应蛋白和D-二聚体对急性白血病伴感染患者的临床检查价值。方法选取该院血液科2011年1月—2013年12月诊断为急性白血病的住院病人,诊断为有感染的患者定义为感染组40例;诊断为弥漫性血管内凝血的患者为弥漫性血管内凝血组40例;同时有感染与弥漫性血管内凝血的患者归为感染+弥漫性血管内凝血组40例。测取各组C反应蛋白和D-二聚体数值。结果感染组、弥漫性血管内凝血组及感染+弥漫性血管内凝血组C反应蛋白和D-二聚体分别为[(42.8依10.5)mg/L、(0.8依0.3)μg/L;(16.5依5.8)mg/L、(1.5依0.6)μg/L;(88.7依21.7)mg/L、(6.8依1.7)μg/L],C反应蛋白和D-二聚体以联合组最高,弥漫性血管内凝血组最低,三组的差异有统计学意义(P<0.05);以C反应蛋白[(<10 mg/L)、(10≤,<100 mg/L)、(≥100 mg/L)]进行分层,CRP≥100 mg/L的人群中,发生DIC比例及血中D-二聚体值最高,而C反应蛋白<10 mg/L的人群中,发生DIC比例及血中D-二聚体值最低,差异有统计学意义(P<0.05)。结论该研究认为急性白血病病人普遍存在感染和异常凝血,可以C反应蛋白和D-二聚体作为检测指标,判断患者是否有发生弥漫性血管内凝血与感染的风险。%Objective To evaluate the value of clinical examination of C-reactive protein and D-dimer in acute leukemia patients with infection. Methods The inpatients diagnosed with acute leukemia in the Department of Hematology of our hospital were se-lected. Those acute leukemia patients complicated by infection were set as the infection group(40 cases), those complicated by dis-seminated intravascular coagulation(DIC) were set as the disseminated intravascular coagulation group(40 cases), and those compli-cated by infection and DIC were set as the infection and disseminated intravascular coagulation group(40 cases). And the values of C-reactive protein and D-dimer

  2. Adjusting wheal size measures to correct atopy misclassification

    Directory of Open Access Journals (Sweden)

    Zhang H

    2011-08-01

    Full Text Available Hongmei Zhang1,*, Wilfried Karmaus1,*, Jianjun Gan2, Weichao Bao1,*, Yan D Zhao3, Dewi Rahardja3, John W Holloway5, Martha Scott4,5, Syed Hasan Arshad4,51Department of Epidemiology and Biostatistics, The University of South Carolina, Columbia, SC, USA; 2GlaxoSmithKline, Research Triangle Park, NC, USA; 3Department of Clinical Science and Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA; 4The David Hide Asthma and Allergy Research Center, St Mary’s Hospital, Newport, Isle of Wight, UK; 5School of Medicine, University of Southampton, Southampton, UK *These authors contributed equally to this articlePurpose: Skin prick testing (SPT is fundamental to the practice of clinical allergy identifying relevant allergens and predicting the clinical expression of disease. Wheal sizes on SPT are used to identify atopic cases, and the cut-off value for a positive test is commonly set at 3 mm. However, the measured wheal sizes do not solely reflect the magnitude of skin reaction to allergens, but also skin reactivity (reflected in the size of histamine reaction and other random or non-random factors. We sought to estimate wheal sizes exclusively due to skin response to allergens and propose gender-specific cutoff points of atopy.Methods: We developed a Bayesian method to adjust observed wheal sizes by excluding histamine and other factor effects, based on which revised cutoff points are proposed for males and females, respectively. The method is then applied to and intensively evaluated using a study population aged 18, at a location on the Isle of Wight in the United Kingdom. To evaluate the proposed approach, two sample t-tests for population means and proportion tests are applied.Results: Four common aeroallergens, house dust mite (HDM, grass pollen, dog dander, and alternaria are considered in the study. Based on 3 mm cutoff, males tend to be more atopic than females (P-values are between 0.00087 and 0.062. After applying the

  3. Selection of the open pit mining cut-off grade strategy under price uncertainty using a risk based multi-criteria ranking system / Wybór strategii określania warunku opłacalności wydobycia w kopalniach odkrywkowych w warunkach niepewności cen w oparciu o wielokryterialny system rankingowy z uwzględnieniem czynników ryzyka

    Science.gov (United States)

    Azimi, Yousue; Osanloo, Montza; Esfahanipour, Akbar

    2012-12-01

    Cut-off Grade Strategy (COGS) is a concept that directly influences the financial, technical, economic, environmental, and legal issues in relation to exploitation of a mineral resource. A decision making system is proposed to select the best technically feasible COGS under price uncertainty. In the proposed system both the conventional discounted cash flow and modern simulation based real option valuations are used to evaluate the alternative strategies. Then the conventional expected value criterion and a multiple criteria ranking system were used to rank the strategies based on the two valuation methods. In the multiple criteria ranking system besides the expected value other stochastic orders expressing abilities of strategies in producing extra profits, minimizing losses and achieving the predefined goals of the exploitation strategy are considered. Finally, the best strategy is selected based on the overall average rank of strategies through all ranking systems. The proposed system was examined using the data of Sungun Copper Mine. To assess the merits of the alternatives better, ranking process was done at both high (prevailing economic condition) and low price conditions. Ranking results revealed that at different price conditions and valuation methods, different results would be obtained. It is concluded that these differences are due to the different behavior of the embedded option to close the mine early, which is more likely to be exercised under low price condition rather than high price condition. The proposed system would enhance the quality of decision making process by providing a more informative and certain platform for project evaluation.

  4. Family Adjustment to Aphasia

    Science.gov (United States)

    ... Public / Speech, Language and Swallowing / Disorders and Diseases Family Adjustment to Aphasia Richard S. was a senior manager ... It also presents a great challenge to the family. There may be tension among family members and ...

  5. Remotely Adjustable Hydraulic Pump

    Science.gov (United States)

    Kouns, H. H.; Gardner, L. D.

    1987-01-01

    Outlet pressure adjusted to match varying loads. Electrohydraulic servo has positioned sleeve in leftmost position, adjusting outlet pressure to maximum value. Sleeve in equilibrium position, with control land covering control port. For lowest pressure setting, sleeve shifted toward right by increased pressure on sleeve shoulder from servovalve. Pump used in aircraft and robots, where hydraulic actuators repeatedly turned on and off, changing pump load frequently and over wide range.

  6. Weighted triangulation adjustment

    Science.gov (United States)

    Anderson, Walter L.

    1969-01-01

    The variation of coordinates method is employed to perform a weighted least squares adjustment of horizontal survey networks. Geodetic coordinates are required for each fixed and adjustable station. A preliminary inverse geodetic position computation is made for each observed line. Weights associated with each observed equation for direction, azimuth, and distance are applied in the formation of the normal equations in-the least squares adjustment. The number of normal equations that may be solved is twice the number of new stations and less than 150. When the normal equations are solved, shifts are produced at adjustable stations. Previously computed correction factors are applied to the shifts and a most probable geodetic position is found for each adjustable station. Pinal azimuths and distances are computed. These may be written onto magnetic tape for subsequent computation of state plane or grid coordinates. Input consists of punch cards containing project identification, program options, and position and observation information. Results listed include preliminary and final positions, residuals, observation equations, solution of the normal equations showing magnitudes of shifts, and a plot of each adjusted and fixed station. During processing, data sets containing irrecoverable errors are rejected and the type of error is listed. The computer resumes processing of additional data sets.. Other conditions cause warning-errors to be issued, and processing continues with the current data set.

  7. 辨认和控制能力精神医学评定量表划界标准与实证效度%Cut-off point and empirical validity of psychiatric assessment scale of cognitive and volition capacity in crime

    Institute of Scientific and Technical Information of China (English)

    李毅; 高北陵; 胡峰; 李学武; 王轶; 吴冬凌

    2014-01-01

    目的 检验辨认和控制能力精神医学评定量表(Psychiatric Assessment Scale of Cognitive and Volition Capacity in crime,PASCVC)的实证效度,并制定全国常模.方法 于2009年8月至2011年12月间在全国七大行政区的十五家司法鉴定机构共收集评定辨认和控制能力的司法精神鉴定案例1 000例,由量表评定者用PASCVC、精神病人限定刑事责任能力评定量表(Diminished Criminal Responsibility Rating Scale,DCRRS)和暴力作案行为人刑事责任能力评定量表(Criminal Responsibility Rating Scale of Violence,CRRSV)进行评分,所有案例均由鉴定人做出辨认和控制能力完全丧失、大部分丧失、部分丧失、小部分丧失、稍有受损和正常的六个等级判断.结果 ①依据频数分布表的结果得出:辨认和控制能力完全丧失的划界分为≤56、大部分丧失为57~ 66、部分丧失为67~76、小部分丧失为77~ 87、稍有受损为88~ 100、正常为≥101.②六级划界分评定的等级划分结果与专家鉴定意见的相关为0.939 (P=0.001).③PASCVC与DCRRS和CRRSV的一致性Kappa值分别为0.838和0.835 (P<0.001).④PASCVC量表评定和专家评定两种方法分别建立判别函数,回代判别量表与专家判断的正确率分别为86.9%和85.1%;两种分级结果的一致性Kappa值为0.857 (P<0.001).结论 该量表具有较好的实证效度,可作为辨认和控制能力司法鉴定的客观评定工具.%Objective To test the cut-off point and empirical validity of psychiatric assessment scale of cognitive and volition capacity for suspects in crime (PASCVC).Methods One thousand of forensic psychiatry cases from fifteen bodies of the seven administrative regions in China were collected for forensic assessment by the three scales of PASCVC,DCRRS and CRRSV in August 2009 to December 201 l.in all cases by the appraiser to make six grade judgment of the cognitive and volition capacity including completely lost

  8. Clinical values and optimal cut-off points of basic vital signs in early identiifcation of critical hand, foot, and mouth disease%基础生命体征对危重型手足口病的早期诊断价值

    Institute of Scientific and Technical Information of China (English)

    杜兴媛; 李英; 邓坤; 温淑媚; 蓝灵利; 侯国祯; 张宝明

    2015-01-01

    Objective To study the clinical values of basic vital signs in early identiifcation of critical hand-foot-mouth disease (HFMD). Methods The clinical data of 358 children with severe HFMD [212 cases in stage 2 (central nervous system involvement) and 146 cases in stage 3 (earlier stage of cardiopulmonary failure, critical type)] were reviewed. The diagnostic values of peak temperature and duration of fever, as well as the heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) in different age groups, for critical HFMD (stage 3) were analyzed using the receiver operating characteristic (ROC) curve. Results HFMD might progress to critical type in case of HR ≥148.5 beats/minutes, RR ≥36.5 times/minutes, SBP≥95 mm Hg, and DBP≥59 mm Hg among children aged 0-1 year. HR≥142.5 times/minutes, RR≥31.5 times/mintes, SBP≥103 mm Hg, and DBP≥60.5 mm Hg in children aged 1-2 years had a certain diagnostic value for critical HFMD. HFMD might progress to critical type in case of HR ≥139.5 times/minutes, RR ≥29.5 times/minutes, and SBP≥103 mm Hg among children ≥3 years of age. The sensitivity and speciifcity of every indicator were higher than 0.517 and 0.769, respectively. The area under the ROC curve (AUC) for peak temperature was 0.507 (P=0.816, compared with AUC=0.5). When the duration of fever was≥5.5 days, the sensitivity and speciifcity were 0.589 and 0.571, respectively. Conclusions HR, RR, and BP are good indicators to identify critical HFMD (stage 3) early. The optimal cut-off points conform to the age characteristics of children. DBP in children ≥3 years of age, peak temperature, and duration of fever have a low value in early identiifcation of critical HFMD.%目的:探讨基础生命体征在早期识别危重型手足口病中的诊断价值。方法收集2010年1月至2014年8月358例重症手足口病患儿(2期重型212例,3期危重型146例)的临床资料,

  9. Use of a Sampling Area-Adjusted Adenosine Triphosphate Bioluminescence Assay Based on Digital Image Quantification to Assess the Cleanliness of Hospital Surfaces

    Directory of Open Access Journals (Sweden)

    Yu-Huai Ho

    2016-06-01

    Full Text Available Contaminated surfaces play an important role in the transmission of pathogens. We sought to establish a criterion that could indicate “cleanliness” using a sampling area–adjusted adenosine triphosphate (ATP assay. In the first phase of the study, target surfaces were selected for swab sampling before and after daily cleaning; then, an aerobic colony count (ACC plate assay of bacteria and antibiotic-resistant bacteria was conducted. ATP swabs were also tested, and the ATP readings were reported as relative light units (RLUs. The results of the ACC and ATP assays were adjusted according to the sampling area. During the second phase of the study, a new cleaning process employing sodium dichloroisocyanurate (NaDCC was implemented for comparison. Using the criterion of 2.5 colony-forming units (CFU/cm2, 45% of the sampled sites were successfully cleaned during phase one of the study. During phase two, the pass rates of the surface samples (64% were significantly improved, except under stringent (5 RLU/cm2 and lax (500 RLU ATP criteria. Using receiver-operating characteristic curve analysis, the best cut-off point for an area-adjusted ATP level was 7.34 RLU/cm2, which corresponded to culture-assay levels of <2.5 CFU/cm2. An area adjustment of the ATP assay improved the degree of correlation with the ACC-assay results from weak to moderate.

  10. Diagnostic Value of D-Dimer’s Serum Level in Iranian Patients with Cerebral Venous Thrombosis

    Science.gov (United States)

    Hashami, Leila; Rakhshan, Vahid; Karimian, Hoda; Moghaddasi, Mehdi

    2016-01-01

    Cerebral venous thrombosis (CVT) is a long-term debilitating vascular brain disease with high morbidity and mortality. It may be associated with rise in D-dimer level. The aim of this study was to examine this potential association and identify the critical D-dimer cut-off level corresponding to increase the risk of CVT. This case-control study was conducted on two groups of patients with and without CVT attending the Rasool Akram Hospital (Iran) during 2014 and 2015. D-dimer levels were measured by the rapid sensitive D-dimer assay. Data were analyzed by Spearman’s correlation coefficient test, independent-samples t-test, backward-selection multiple linear regression and multiple binary logistic regression analyses. Sensitivity-specificity tests were used to detect D-dimer cut-off for CVT. Differences between the D-dimer levels of the case and control groups were significant (P<0.001). It showed that each level of increase in the number of symptoms could increase the risk of thrombosis occurrence for about 3.5 times. All symptom types except for headache were associated with D-dimer level, while headache has negative association with D-dimer level. D-dimer cut-off point for CVT diagnosis was estimated at 350 ng/mg. We concluded that D-dimer serum level significantly rises in CVT patients. A rounded cut-off point of 350 ng/mg can be used as a diagnostic criterion for CVT prediction. PMID:27441064

  11. Diagnostic value of D-dimer’s serum level in Iranian patients with cerebral venous thrombosis

    Directory of Open Access Journals (Sweden)

    Leila Hashami

    2016-06-01

    Full Text Available Cerebral venous thrombosis (CVT is a longterm debilitating vascular brain disease with high morbidity and mortality. It may be associated with rise in D-dimer level. The aim of this study was to examine this potential association and identify the critical D-dimer cut-off level corresponding to increase the risk of CVT. This case-control study was conducted on two groups of patients with and without CVT attending the Rasool Akram Hospital (Iran during 2014 and 2015. D-dimer levels were measured by the rapid sensitive D-dimer assay. Data were analyzed by Spearman’s correlation coefficient test, independent-samples t-test, backward-selection multiple linear regression and multiple binary logistic regression analyses. Sensitivity-specificity tests were used to detect D-dimer cut-off for CVT. Differences between the D-dimer levels of the case and control groups were significant (P<0.001. It showed that each level of increase in the number of symptoms could increase the risk of thrombosis occurrence for about 3.5 times. All symptom types except for headache were associated with D-dimer level, while headache has negative association with D-dimer level. D-dimer cut-off point for CVT diagnosis was estimated at 350 ng/mg. We concluded that D-dimer serum level significantly rises in CVT patients. A rounded cut-off point of 350 ng/mg can be used as a diagnostic criterion for CVT prediction.

  12. Predicting deep venous thrombosis using Wells scoring system combined with D-dimer and fibrin degradation product%复合骨折后下肢深静脉血栓形成Wells评分与D-二聚体及纤维蛋白降解产物的预测

    Institute of Scientific and Technical Information of China (English)

    沈明荃; 谢增如

    2014-01-01

    背景:文献报道各种对深静脉血栓形成的诊断方法,但是结合危险度预测评分系统及多种实验室指标对深静脉血栓形成的预测诊断率的提高尚不明确。  目的:使用Wel s评分系统并结合D-二聚体及纤维蛋白降解产物提高诊断创伤后下肢深静脉血栓敏感性。方法:下肢骨折及脊柱骨折患者82例,排除患病前合并深静脉血栓形成高危因素的患者及曾患有深静脉血栓形成的患者。入院后检测患者D-二聚体、纤维蛋白酶原降解产物、纤维蛋白酶原、凝血酶原时间、部分活化凝血酶原时间、血小板计数、C-反应蛋白及血沉相关指标,并做彩色多普勒下肢超声检测。根据下肢深静脉栓塞评分表(Wel s评分表)评分分为低危、中危及高危患者。  结果与结论:彩色多普勒下肢超声检测深静脉血栓形成组30例;非深静脉血栓形成组52例,两组患者 D-二聚体及纤维蛋白降解产物的峰值差异有显著性意义(P OBJECTIVE:To improve the diagnosis sensitivity of traumatic deep venous thrombosis of lower extremity using Wel s scoring system combined D-dimer and fibrin degradation product. METHODA total of 82 patients with low limb fractures and spine fracture were included in this study, those patients with high risk factors of deep venous thrombosis or with the history of deep venous thrombosis were excluded. After admission, the fol owing indicators of deep venous thrombosis were determined, including D-dimer, fibrin degradation product, fibrinogenase, prothrombin time, activated partial thrombokinase time, blood platelets count, C-reaction protein, and erythrocyte sedimentation rate. In addition, Doppler ultrasound detection of double lower limbs deep vein was performed, and the results were recorded. According to scoring system of deep venous thrombosis of lower extremity (Wel s scoring system), the patients were assigned into low-risk, middle

  13. 高压氧联合神经节苷脂对脑出血患者凝血酶、血清髓鞘碱性蛋白、D-二聚体的影响%Effect of hyperbaric oxygen combined with ganglion glycosides on thrombin, serum myelin basic protein and D-dimer in patients with intracerebral hemorrhage

    Institute of Scientific and Technical Information of China (English)

    陈伟; 王茂德; 王宁; 鲍刚; 王拓

    2016-01-01

    Objective To observe the effect of hyperbaric oxygen combined with ganglion glycosides on thrombin, se-rum myelin basic protein and D-dimer in patients with intracerebral hemorrhage.Methods Selected from June 2014 to June 2015, 100 cases of cerebral hemorrhage patients in Xi'an Jiaotong University First Affiliated Hospital neurosurgery department as the research object, according to the order of admission, they were randomly divided into control group and observation group, each group of 50 cases, on the basis of conventional therapy patients in control group were treated with ganglioside treatment, the observation group given hyperbaric oxygen combined with ganglioside treatment.Before and after treatment, thrombin, serum myelin basic protein, D-dimer, hematoma volume, neurological function defect score ( NIHSS) , daily life a-bility score ( ADL) were observed, and the clinical effect was evaluated.Results Before treatment, 2 groups of thrombin, serum myelin basic protein ( MBP) , D-dimer, volume of hematoma, NIHSS and ADL score differences had no statistical sig-nificance ( P >0.05), after treatment, two groups of thrombin, serum myelin basic protein (MBP), D-dimer, hematoma volume and NIHSS score compared with those before treatment were significantly decreased ( P <0.05), ADL score before treatment were significantly higher ( P <0.05) , and the observation group was more obvious than that of the control group, the above indicators improved ( P <0.05).The control group cured rate, significant progress rate, improvement rate were 24.00%, 36.00%, 24.00%, the observation group were 30.00%and 40.00%, 24.00%observed group, the total efficien-cy is remarkably higher than that of the control group (94.00%vs.84.00%,χ2 =3.55, P <0.05).Conclusion Hyperbaric oxygen combined with ganglion glycosides can reduce the level of thrombin, serum myelin basic protein and D-dimer levels in patients with cerebral hemorrhage,and improve the therapeutic effect.%目的:观察高压

  14. Relationship between serum biomarkers of procalcitonin, lactate, D-dimer and disease severity in sepsis children%降钙素原、乳酸、D-二聚体水平与脓毒血症患儿病情的关系

    Institute of Scientific and Technical Information of China (English)

    汪江萍; 刘自光; 郭彩云

    2013-01-01

    Objective To explore the relationship between serum biomarkers of procalcitonin (PCT),lactate,D-dimer and disease severity in sepsis children.Methods 86 cases of sepsis were reviewed from January 2008 to January 2013.86 cases of sepsis were classified as early sepsis group,severe sepsis group and septic shock group.Patients were divided into survival group and death group according to their outcome.Serum biomarkers of PCT,lactate and D-dimer were measured and were analyzed their correlation with the prognosis of critically ill children according to pediatric critical illness score (PCIS).Results There were significantly difference on the level of three biomarkers in early sepsis group,severe sepsis group and septic shock group (P<0.05).There were significantly negative correction on the survival group and death group with PCIS (P<0.05).Conclusions The joint detection of serum biomarkers of PCT,lactate and D-dimer has guiding significance in the early diagnosis for children sepsis.Children with higher PCT,lactate and D-dimerin levels and lower PCIS were worse and had poorer prognosis.%目的 探讨血降钙素原(PCT)、乳酸和D-二聚体3种生物标记物评估脓毒血症患儿病情严重程度及预后的临床价值.方法 收集2008年1月至2013年1月86例脓毒血症患儿的临床资料,将其按病情严重程度分为早期脓毒症组、严重脓毒症组和脓毒症休克组;回顾性研究则将所有患儿根据预后分为生存组及死亡组.分别比较各组患儿血降钙素原、乳酸、D-二聚体水平和小儿危重病例评分(PCIS),观察血降钙素原、乳酸、D-二聚体3种标记物水平评估病情严重程度及预后的临床价值.结果 不同严重程度的脓毒血症的3组患儿中,3种标记物水平及PCIS比较差异均有统计学意义(P<0.05).生存组患儿血降钙素原、乳酸、D-二聚体水平和PCIS与死亡组比较差异均有统计学意义(P<0.05),且呈负相关关系.结论 血降钙素原

  15. Wells 量表和修正的 Geneva 评分联合 D-二聚体对肺栓塞的预测价值%The validity of Wells'Criteria and Geneva Scoring System (revised) combined with D-dimer in predicting pulmonary embolism

    Institute of Scientific and Technical Information of China (English)

    凌燕君; 邹晓

    2015-01-01

    目的:评价Wells量表和修正的Geneva评分系统联合D-二聚体诊断肺栓塞的意义。方法应用受试者工作特征曲线,通过Wells量表和修正的Geneva评分系统联合D-二聚体检验方法,得出修正的Geneva和Wells评分,联合D-二聚体阳性来比较两种方法的差别。结果通过Wells评分的ROC曲线得出以≥4.25作为预测值,其灵敏度30.2%,特异度92.6%;通过Geneva评分的ROC曲线得细化以≥6.5作为预测值,其灵敏度64.7%,特异度85.2%。在Wells评分中以最佳分界值4.25分为界,Geneva评分中以最佳分界值6.5分为界,联合D-二聚体检测准确率有明显差别。结论根据Geneva评分≥6.5分或Wells评分≥4.25分者联合D-二聚体阳性时,高度怀疑肺栓塞。%Objective To evaluate the validity of Wells’ Criteria and Geneva Scoring System combined with D-dimer as two different methods for predicting pulmonary embolism.Method The Wells score and the Geneva score were first obtained by the Wells’ Criteria and the Geneva Scoring System ( revised) combined with D – dimer respectively.The validity of the two methods was then evaluated and compared for their difference in accuracy sensitivity, and specificity.Findings The Wells score evaluated by the ROC curve was≥4.25 as the predictive value.Its sensitivity was 30.2%and its specificity of 92.6%.The Geneva score evaluated by the ROC curve was refined to≥6.5 as the predictive value.Its sensitivity was 64. 7%and its specificity of 85.2%.Of the Wells scores the best cutoff value was 4.25 while of the Geneva optimal the optimal cutoff score was 6.5.Combined with D-dimer, significant difference could be found between the two methods. Conclusion The sensitivity and specificity of the revised Geneva score were better than those of the Wells rule.When the revised Geneva scores arrive at a value≥6.5 or the Wells scores arrive a value≥4.25, and the D-dimer is positive

  16. The significance of detection of D-dimer, fibrinogen and antithrombin-Ⅲin the patients with typy-2 diabet-ic nephropathy%D-二聚体、纤维蛋白原及抗凝血酶Ⅲ联合检测对早期2型糖尿病肾病的诊断价值

    Institute of Scientific and Technical Information of China (English)

    杨玲

    2015-01-01

    目的:探究D-二聚体、纤维蛋白原( FIB)及抗凝血酶Ⅲ( AT-Ⅲ)联合检测2型糖尿病早期肾损伤的临床诊断价值。方法选取某院2型糖尿病患者206例,根据24 h尿白蛋白排泄率( UAE)分为无蛋白尿组116例( UAE<30 mg/24 h)与微量白蛋白尿组90例(30 mg/24 h≤UAE<300 mg/24 h),并选取同期健康体检者103例作为健康对照组,比较血浆D-二聚体、FIB、AT-Ⅲ3项指标的变化。结果微量白蛋白尿组D-二聚体、FIB含量明显高于无蛋白尿组和健康对照组,差异均有统计学意义(P<0畅05),而三组AT-Ⅲ的活性比较差异无统计学意义(P>0畅05)。3项指标联合检测的微量蛋白尿组患者为93畅3%,比单项检测的阳性率高,差异有统计学意义(P<0畅05)。 D-二聚体、FIB、AT-Ⅲ与尿白蛋白排泄率呈正相关,相关系数(r)依次为0畅812、0畅672、0畅621(P<0畅05)。结论 D-二聚体、FIB检测对于2型糖尿病肾病的早期判断以及疾病的早期预防和病情监测有重要意义。%Objective To explore the D-dimer, fibrinogen (FIB), antithrombin Ⅲ (AT-Ⅲ) joint detection of early renal damage in type 2 diabetes to assess the diagnostic value of clinical application.Methods According to the 24 h urine albumin excre-tion rate ( UAE) , 206 patients selected from type 2 diabetes patients were divided into 116 cases without albuminuria group ( UAE0.05).Three indicators of joint detection of trace albuminuria group of patients was 93.3%, positive rate than single detection are high, the difference was statistically significant (P<0.05).D-dimer, FIB, the AT-Ⅲand UAE are positively related to the level of the correlation coefficient r of 0.812, 0.672, and 0.621 (P<0.05).Conclusion The detection of D-dimer, FIB in type 2 diabetic nephropathy early judgement and early prevention of disease and illness monitoring is im-portant.

  17. 五种D-二聚体检测方法用于排除可疑静脉血栓栓塞症的临床评价%Evaluation of Five D-dimer Assays for the Exclusion of Venous Thromboembolism

    Institute of Scientific and Technical Information of China (English)

    周静; 孙家瑜; 孙加冠; 刘琳; 徐勇; 江虹

    2009-01-01

    目的 评价5种D-二聚体(D-dimer,DD)检测方法在排除疑似静脉血栓栓塞症(VTE)中的价值.方法 采用传统酶联免疫吸附法(ELISA)、快速ELISA法(VIDAS DD)、光电散射免疫比浊法(DD Plus)、免疫比浊法(Liatest STAGO DD)、胶体金免疫渗透法(NycoCard DD),检测75例临床疑似VTE患者血浆DD含量,其结果与疾病诊断的金标准进行比较,以评价各种方法的特点、相关性及诊断效能.结果 Liatest STAGO DD、DD Plus,VIDAS DD、传统ELISA DD检测都显示出良好的诊断效能(AUC均大于0.7),其中Liatest STAGO DD 的敏感性(96.7%)和阴性预测值(95.5%)最高,AUC(0.814)最大,对排除VTE的诊断效能最大.传统ELISA法的特异性最高,为48.9%.各方法间有明显的相关性,其中VIDAS DD与Liatest STAGO DD相关性最好(r=0.9106),与传统ELISA方法相关性比较表明Liatest STAGO DD和VIDAS DD与传统ELISA方法相关性较好,r分别为0.8360和0.8764.结论 Liatest STAGO DD、DD Plus、VIDAS DD检测快速简便,适用于单个样本的检测,有良好的诊断效能,有望取代传统ELISA法用于临床;临床应结合自身实际情况选择DD检测方法并确定其用于排除VTE的临界值.%Objective To evaluate the diagnostic performance of five D-dimer assays for the exclusion of suspected venous thromboembolis (VTE). Methods The plasma D-dimer levels of 75 suspected VTE patients were tested with ELISA, VIDAS DD, DD Plus, Liatest STAGO DD, and NycoCard DD. The results of the five assays were compared with the gold standard of diagnosis of VTE. Results Liatest STAGO DD, DD Plus, VIDAS DD and ELISA had good diagnostic performance for the exclusion of suspected VTE. Liatest STAGO DD had the greatest accuracy for differentiating diagnosis, with 0. 814 of area under the curve (AUC), 96. 7% of sensitivity, and 95. 5% of negative predictive value. ELISA had the greatest specificity (48. 9%). The five assays showed good correlations, with VIDAS DD and Liatest STAGO DD

  18. Auto Adjusting Astronomical Telescope

    Directory of Open Access Journals (Sweden)

    Rohit R. Ghalsasi

    2014-04-01

    Full Text Available Astronomical telescope is powerful and basic tool for star or celestial observation. Here we proposed integrated system using Raspberry Pi for auto adjusting astronomical telescope. This integrated circuit helps to control stellar monitoring, stellar targeting, and tracking functions of telescope. Astro compass gives the direction of the celestial objects.

  19. Psychological Adjustment and Homosexuality.

    Science.gov (United States)

    Gonsiorek, John C.

    In this paper, the diverse literature bearing on the topic of homosexuality and psychological adjustment is critically reviewed and synthesized. The first chapter discusses the most crucial methodological issue in this area, the problem of sampling. The kinds of samples used to date are critically examined, and some suggestions for improved…

  20. Sustainable urban regime adjustments

    DEFF Research Database (Denmark)

    Quitzau, Maj-Britt; Jensen, Jens Stissing; Elle, Morten;

    2013-01-01

    The endogenous agency that urban governments increasingly portray by making conscious and planned efforts to adjust the regimes they operate within is currently not well captured in transition studies. There is a need to acknowledge the ambiguity of regime enactment at the urban scale. This direc...

  1. 妊娠高血压患者与D-二聚体、维生素B12、血清同型半胱氨酸的关系%The relationship between pregnancy-induced hypertension and D-dimer, vitamin B12 and serum homocysteine

    Institute of Scientific and Technical Information of China (English)

    俞小飞; 徐燕; 张梦

    2015-01-01

    目的:探讨不同孕期孕妇D-二聚体(D-D)、维生素B12、血清同型半胱氨酸(HCY)与妊娠高血压疾病(PIH)之间的关系。方法:选取在我院进行产检的孕妇287例为研究对象,其中PIH孕妇86例,正常妊娠孕妇201例,根据孕期对不同孕妇血清D-D、维生素B12、HCY水平进行检测。结果:PIH组与正常妊娠组比较,孕中期及孕晚期血清HCY水平与D-D水平明显升高(P<0.05),且在孕中期及孕晚期,PIH组及正常妊娠组孕妇血清HCY水平与D-D水平呈正相关,而与维生素B12均无相关性。结论:在孕中晚期进行HCY水平及D-D水平检测可作为预测PIH的一个重要的危险因素。%Objective:To evaluate the Relationship between the serum levels of homocysteine, D-dimer, vitamin B12 and pregnancy-induced hypertension in different pregnancies. Methods:287 pregnant women who registered for prenatal examination of pregnant in the hospital were selected as research subjects. And there were 86 cases of PIH and 201 cases of normal pregnancy among them. The serum levels of homocysteine, D-dimer, vitamin B12 were detected according to different pregnancy.Results:Compared with normal pregnancy group, the serum HCY and D-D level of PIH group significantly increased in medium and late pregnancy periods (P0.05). Conclusions:n middle and late pregnancy periods, to detect the levels of HCY and D-D be an improtant risk factor of PIH.

  2. 急性冠脉综合征中超敏C反应蛋白联合D-二聚体检测的研究进展%THE DEVELOPMENT OF COMBINED TESTING OF HYPER-SENSITIVE C REACTIVE PROTEIN AND D-DIMER IN ACUTE CORONARY SYMDROME

    Institute of Scientific and Technical Information of China (English)

    杜丽萍; 扈瑞平; 王学磊; 曾显坤

    2015-01-01

    ACS的临床表现可为,胸闷、胸痛伴气短、出汗,心衰,心律失常以及猝死。并伴有冠脉血管痉挛,管腔明显狭窄,甚至完全被堵塞,从而出现心肌缺血缺氧,严重时心肌坏死[1]。近年来研究发现:其进展过程中伴随的生化标记物超敏C反应蛋白、D-二聚体的改变可帮助临床医师及早识别病人的临床症状并为心电图改变不典型病人提供积极个体化的治疗方案,同时对评估其病情及预后、起到极大的作用。现将对急性冠脉综合征中( ACS)超敏C反应蛋白联合D-二聚体检测的研究进展进行综述。%Acute coronary symdrome( ACS) is caused by cononary atherosclerosis rupture, platelet adhesion, platelet aggregation, platelet release, through which the coagulation system is activated leading to the blood clot. ACS is usually accompanied by vasospasm,stenosis of arte-rioles,even worse,myocardial ischemia from completely blocking and myocardial necrosis. The research tells us that through biochemical marker-hyper sensitive C reactive protein and D-dimer ( increase ) , phisician can recognize some symdromes in early time,help ACS patients with atypical ECG changes and give them individual treatment;in addition,the two marker also play an important role in evaluating severity and prognosis. This review will present development in application of hyper-sensitive C reative protein and D-dimer in ACS.

  3. 重症肺炎患者FDP、D-二聚体和炎症指标的变化及临床意义%Change and the clinical significance of fibrinogen degradation products,D-dimer and inflammatory indicators in the patients with severe pneumonia

    Institute of Scientific and Technical Information of China (English)

    徐巧巧; 邢丽华

    2015-01-01

    Objective To observe the change of fibrinolytic system function,D-dimer and inflammatory index in the patients with severe pneumonia,and to investigate the clinical significance.Methods Forty patients with severe pnemonia from June 2013 to June 2014 in the RICU in the first affiliated hospital of Zhengzhou university and forty cases of health check-up in the same period in the physical examination center were selected.The fibrinogen degradation (FDP),D-dimer (D-D),procalcitonin (PCT),C-reactive protien(CRP),erythrocyte sedimentation rate (ESR) in the serum were tested.Results Campared with the control group,the FDP and D-D significanty increased and the value of PCT,CRP,ESR elevated in the group with severe pneumonia(P <0.05).Conclusions The FDP and the D-D can reflect the function of blood coagulation system.The mechanism of coagulation and fibrinolytic function becomes disorder for the patients with severe pneumonia,which is related to the inflamamation.So observation for the changes of the above indexes might be helpful for the conditon assessment and the treatment.%目的 探讨重症肺炎患者纤溶系统功能和炎症指标的变化及临床意义.方法 选取2013年6月至2014年6月期间入住郑州大学第一附属医院RICU的40例重症肺炎患者与本院体检中心同期40例健康体检者作为研究对象,分别测定其血清中的纤维蛋白原降解产物(FDP)、D-二聚体(D-D)、降钙素原(PCT)、C-反应蛋白(CRP)、血沉(ESR).结果 重症肺炎组FDP及D-D明显升高,PCT、CRP、ESR水平升高,与正常对照组比较差异有统计学意义(P<0.05).结论 重症肺炎患者存在凝血纤溶系统功能的紊乱与炎症反应有关,FDP和D-D反应凝血纤溶系统的功能,注意FDP、D-D及炎症指标的变化在重症肺炎病情评估及指导治疗中具有一定价值.

  4. Use of a Sampling Area-Adjusted Adenosine Triphosphate Bioluminescence Assay Based on Digital Image Quantification to Assess the Cleanliness of Hospital Surfaces.

    Science.gov (United States)

    Ho, Yu-Huai; Wang, Lih-Shinn; Jiang, Hui-Li; Chang, Chih-Hui; Hsieh, Chia-Jung; Chang, Dan-Chi; Tu, Hsin-Yu; Chiu, Tan-Yun; Chao, Huei-Jen; Tseng, Chun-Chieh

    2016-06-09

    Contaminated surfaces play an important role in the transmission of pathogens. We sought to establish a criterion that could indicate "cleanliness" using a sampling area-adjusted adenosine triphosphate (ATP) assay. In the first phase of the study, target surfaces were selected for swab sampling before and after daily cleaning; then, an aerobic colony count (ACC) plate assay of bacteria and antibiotic-resistant bacteria was conducted. ATP swabs were also tested, and the ATP readings were reported as relative light units (RLUs). The results of the ACC and ATP assays were adjusted according to the sampling area. During the second phase of the study, a new cleaning process employing sodium dichloroisocyanurate (NaDCC) was implemented for comparison. Using the criterion of 2.5 colony-forming units (CFU)/cm², 45% of the sampled sites were successfully cleaned during phase one of the study. During phase two, the pass rates of the surface samples (64%) were significantly improved, except under stringent (5 RLU/cm²) and lax (500 RLU) ATP criteria. Using receiver-operating characteristic curve analysis, the best cut-off point for an area-adjusted ATP level was 7.34 RLU/cm², which corresponded to culture-assay levels of ATP assay improved the degree of correlation with the ACC-assay results from weak to moderate.

  5. Metric adjusted skew information

    DEFF Research Database (Denmark)

    Hansen, Frank

    2008-01-01

    establish a connection between the geometrical formulation of quantum statistics as proposed by Chentsov and Morozova and measures of quantum information as introduced by Wigner and Yanase and extended in this article. We show that the set of normalized Morozova-Chentsov functions describing the possible...... quantum statistics is a Bauer simplex and determine its extreme points. We determine a particularly simple skew information, the "¿-skew information," parametrized by a ¿ ¿ (0, 1], and show that the convex cone this family generates coincides with the set of all metric adjusted skew informations.......We extend the concept of Wigner-Yanase-Dyson skew information to something we call "metric adjusted skew information" (of a state with respect to a conserved observable). This "skew information" is intended to be a non-negative quantity bounded by the variance (of an observable in a state...

  6. Fiscal adjustment in Brazil

    Directory of Open Access Journals (Sweden)

    Fabiana Rocha

    2003-03-01

    Full Text Available Two questions are addressed in this paper. The first one is the determination of periods of fiscal consolidation and fiscal stimulus. The second one is the importance of the composition of fiscal adjustments for their success, defined as a declining debt to GDP ratio. We, characterize 1994 and 1999 as points of fiscal consolidation. The 1994 consolidation can not be considered successful since after that period the debt to GDP ratio has grown continuously. The adjustment can be characterized as a type 2 adjustment (Alesina and Perotti (1997 in the sense that cuts were made mainly in public investment, while government wages and transfers remained almost unchanged. This type of adjustment usually has a low likelihood of being a success.Duas questões são tratadas neste artigo. A primeira é a determinação dos períodos de consolidação fiscal e estímulo fiscal. A segunda questão é a importância da composição dos ajustamentos fiscais para o seu sucesso, definido como um declínio na razo dívida/PIB. Nós, caracterizamos 1994 e 1999 como pontos de consolidação fiscal. A consolidação de 1994 não pode ser considerada um sucesso pois nos anos seguintes a razão dívida/PIB cresceu continuamente. O ajustamento pode ser considerado como um ajustamento do tipo 2 (Alesina and Perotti, 1997 no sentido de que foram feitos cortes principalmente no investimento público, enquanto os salários e transferências permaneceram praticamente inalterados. Este tipo de ajustamento geralmente tem uma baixa probabilidade de sucesso.

  7. Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis Avaliação dos níveis séricos de D-dímeros entre doentes com urticária crônica, psoríase e urticária vasculite

    Directory of Open Access Journals (Sweden)

    Paulo Ricardo Criado

    2013-06-01

    Full Text Available BACKGROUND: It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation. We performed a transversal and case-control study of patients with chronic urticaria and patients with psoriasis, in our outpatient clinic to evaluate the production of D-dimer. OBJECTIVE: To evaluate D-dimer serum levels in patients with chronic urticaria and its possible correlation with disease activity. PATIENTS AND METHODS: The study was conducted from October 2010 until March 2011. We selected 37 consecutive patients from our Allergy Unit and Psoriasis Unit, and divided them into three groups for statistical analysis: (i 12 patients with active chronic urticaria (CU; (ii 10 patients with chronic urticaria under remission and (iii 15 patients with psoriasis (a disease with skin inflammatory infiltrate constituted by neutrophils, lymphocytes and monocytes. Another five patients with urticarial vasculitis were allocated in our study, but not included in statistical analysis. The serum levels of D-dimer were measured by Enzyme Linked Fluorescent Assay (ELFA, and the result units were given in ng/ml FEU. RESULTS: Patients with active chronic urticaria had the highest serum levels of D-dimer (p FUNDAMENTOS: Tem sido demonstrado que os neutrófilos, eosinófilos e monócitos, sob estímulo apropriado, podem expressar fator tecidual e, portanto, ativar a via extrínseca da coagulação. Realizamos um estudo transversal e caso-controle de pacientes com urticária crônica e pacientes com psoríase em nosso ambulatório para avaliar a produção de dímero-D. OBJETIVO: Avaliar níveis de dímero-D em pacientes com urticária crônica e sua possível correlação com a atividade da doença. PACIENTES E MÉTODOS: O estudo foi conduzido de outubro de 2010 até março de 2011. Nós selecionamos 37 pacientes consecutivos da Unidade de Alergia e Unidade de

  8. Efficacy of low molecular weight heparin on severe pneumonia in elderly patients with high level of D-dimer%低分子肝素钠辅助治疗D二聚体升高的老年重症肺炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    倪军; 林宏; 孙嵘; 刘伟春; 郑海燕; 王倩

    2013-01-01

    Objective To evaluate the clinical effect and safety of low molecular weight heparin in the treatment of severe pneumonia in elderly patients with high D-dimer.Methods Eighty-nine cases of severe pneumonia with high level of D-dimer were randomly divided into two groups.The experiment group was given subcutaneous injection of low molecular weight heparin 5000 IU/d for 5 to 7 days.The control group was given conventional therapy.Artery Blood oxygen pressure(PaO2) in arterial blood and C-reactive protein concentration (CRP),D-dimer before and after treatment were measured.The fatality rate and adverse drug reactions were observed.Results After anticoagulant therapy,PaO2 in the experimental group had a more significant improvement than that in the control group [(77.4 ± 12.9) mmHg vs (62.8 ±12.3) mmHg,P <0.05].The level of D-dimer in the experiment group had a more significant decrease than that in the control group[(0.66 ±0.38) mg/L vs (1.19 ±0.55) mg/L,P <0.01].The experiment group had shorter hospital stay (days) and lower cost of hospitalization than the control group.There was no statistical difference in the fatality rate between two groups (9.09 % vs 20.45%,P > 0.05).The adverse drug reactions were few and mild in both groups.Conclusions Low molecular weight heparin is effective and safe to severe pneumonia in elderly patients.%目的 观察低分子肝素在老年重症肺炎患者中的治疗作用及不良反应. 方法 将2009年1月自2012年12月闸北区中心医院住院的D二聚体(D-D)升高的老年重症肺炎患者随机分为抗凝组和对照组.抗凝组予低分子肝素钠(法安明5000 IU/d,皮下注射)治疗;对照组仅给予常规治疗.观察2组治疗前后D-D、静脉血C反应蛋白浓度、动脉血氧分压(PaO2).比较2组平均住院天数及住院费用,观察2组病死率及不良反应. 结果 抗凝组治疗后D-D较对照组显著降低(P<0.01),为(0.66±0.38) mg/L和(1.19±0.55) mg/L.抗凝组治疗后PaO2

  9. Adjustment Criterion and Algorithm in Adjustment Model with Uncertain

    Directory of Open Access Journals (Sweden)

    SONG Yingchun

    2015-02-01

    Full Text Available Uncertainty often exists in the process of obtaining measurement data, which affects the reliability of parameter estimation. This paper establishes a new adjustment model in which uncertainty is incorporated into the function model as a parameter. A new adjustment criterion and its iterative algorithm are given based on uncertainty propagation law in the residual error, in which the maximum possible uncertainty is minimized. This paper also analyzes, with examples, the different adjustment criteria and features of optimal solutions about the least-squares adjustment, the uncertainty adjustment and total least-squares adjustment. Existing error theory is extended with new observational data processing method about uncertainty.

  10. Jordan Adjusted Human Development

    OpenAIRE

    Ababsa, Myriam

    2014-01-01

    Jordan Human Development Index (HDI) and Adjusted Human Development Index (IHDI) In 1990, the United Nations Development Programme designed a Human Development Index composed of life expectancy at birth, level of education and gross domestic product (GDP) per capita. In 2011, the UNDP ranked Jordan 95th out of 187 countries with a human development index of 0.698, up from 0.591 in 1990, making it the leading medium-range country for human development (fig. VIII.1). In 2010, the inequality adj...

  11. Adjustable Reeds For Weaving

    Science.gov (United States)

    Farley, Gary L.

    1994-01-01

    Local characteristics of fabrics varied to suit special applications. Adjustable reed machinery proposed for use in weaving fabrics in various net shapes, widths, yarn spacings, and yarn angles. Locations of edges of fabric and configuration of warp and filling yarns varied along fabric to obtain specified properties. In machinery, reed wires mounted in groups on sliders, mounted on lengthwise rails in reed frame. Mechanisms incorporated to move sliders lengthwise, parallel to warp yarns, by sliding them along rails; move sliders crosswise by translating reed frame rails perpendicular to warp yarns; and crosswise by spreading reed rails within group. Profile of reed wires in group on each slider changed.

  12. Continuously adjustable Pulfrich spectacles

    Science.gov (United States)

    Jacobs, Ken; Karpf, Ron

    2011-03-01

    A number of Pulfrich 3-D movies and TV shows have been produced, but the standard implementation has inherent drawbacks. The movie and TV industries have correctly concluded that the standard Pulfrich 3-D implementation is not a useful 3-D technique. Continuously Adjustable Pulfrich Spectacles (CAPS) is a new implementation of the Pulfrich effect that allows any scene containing movement in a standard 2-D movie, which are most scenes, to be optionally viewed in 3-D using inexpensive viewing specs. Recent scientific results in the fields of human perception, optoelectronics, video compression and video format conversion are translated into a new implementation of Pulfrich 3- D. CAPS uses these results to continuously adjust to the movie so that the viewing spectacles always conform to the optical density that optimizes the Pulfrich stereoscopic illusion. CAPS instantly provides 3-D immersion to any moving scene in any 2-D movie. Without the glasses, the movie will appear as a normal 2-D image. CAPS work on any viewing device, and with any distribution medium. CAPS is appropriate for viewing Internet streamed movies in 3-D.

  13. Adolescent Mothers' Adjustment to Parenting.

    Science.gov (United States)

    Samuels, Valerie Jarvis; And Others

    1994-01-01

    Examined adolescent mothers' adjustment to parenting, self-esteem, social support, and perceptions of baby. Subjects (n=52) responded to questionnaires at two time periods approximately six months apart. Mothers with higher self-esteem at Time 1 had better adjustment at Time 2. Adjustment was predicted by Time 2 variables; contact with baby's…

  14. Adjusting to the Emergent

    DEFF Research Database (Denmark)

    Revsbæk, Line

    In her doctoral thesis Line Revsbaek explores newcomer innovation related to organizational entry processes in a changing organization. She introduces process philosophy and complexity theory to research on organizational socialization and newcomer innovation. The study challenges assumptions...... in standardized induction programs where newcomers are cast in roles as insecure novices needing to be “taught the ropes” of the organizational culture. Linked with this, it is suggested that the prevailing dichotomy of ‘newcomer assimilation’ versus ‘organizational accommodation’ is replaced with a notion...... of ‘adjusting to the emergent’. Newcomer innovation is portrayed as carrying a variety of possible significations, such as unintentional innovation effects of newcomer’s proactive self-socializing behavior; an inspirational basis for designing innovation-generating employee induction; ‘resonant instances...

  15. The diagnostic value of plasma D-dimer and fibrinogen in lower limb deep venous thrombosis%血浆D-二聚体与纤维蛋白原在下肢深静脉血栓中的诊断价值

    Institute of Scientific and Technical Information of China (English)

    王旭东

    2014-01-01

    目的:探讨D-二聚体(DD)和纤维蛋白原(FIB)在下肢深静脉血栓形成(DVT)诊断中的临床意义。方法对52例疑似DVT患者进行血浆DD和FIB检测,并计算D-二聚体/纤维蛋白原比值(D/F值),根据彩色多普勒超声检查结果明确诊断,同时选取健康体检者50例作为对照组。结果 DVT组血浆DD、FIB及D/F值均明显高于健康对照组,差异有统计学意义(P<0.01);DVT组与非DVT组比较,DVT组DD、FIB和D/F值明显高于非DVT组具有显著性差异(P<0.01),D/F值、DD、FIB对诊断DVT的敏感度分别为98%、94%、85%,D/F值在诊断DVT中较单独应用DD或FIB有较高的敏感度。结论检测血浆DD、FIB及D/F比值可提高DVT临床诊断的特异性,对下肢深静脉血栓的早期诊断具有重要的临床意义。%Objective To explore the diagnostic value of plasma D-dimer and fibrinogen in lower limb deep venous thrombosis(DVT). Methods 52 patients with suspected DVT were selected to be carried out the test on plasma DD and FIB :and calculated d-dimer/fibrinogen ratio(D/F values).According to color doppler ultrasonography examination results determined diagnosis. At the same time: 50 healthy subjects were in the control group. Results The plasma DD and FIB levels and D/F values in DVT group were significantly higher than that of the healthy control group:the differences were statistically significant(P < 0.01). The plasma DD and FIB levels and D/F values in DVT group were higher than those in non-DVT group:and there was significant difference(P<0.01). The sensitivity of D/F values:DD and FIB were respectively 98%,94%,85%.The D/F values had higher sensitivity than the DD or FIB increased in the diagnosis of DVT. Conclusion The testing of plasma DD:FIB and D/F values could improve the specificity in DVT diagnosis and had important clinical significance on the early diagnosis of DVT.

  16. 脑梗死患者 hs-CRP FIB D-二聚体及血脂相关指标检测结果的分析%Analysis of plasma hs-CRP,FIB,D-dimer and lipids related indicators in patients with cerebral infarction

    Institute of Scientific and Technical Information of China (English)

    郑红云; 李艳; 李松

    2014-01-01

    目的:探讨血脂相关指标、超敏C反应蛋白(hs-CRP)、纤维蛋白原(FIB)和D-二聚体水平与脑梗死发病的相关性。方法选取脑梗死患者259例(脑梗死组),同期健康体检者210例作为对照组。采用酶比色法测定血脂相关指标[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白(Apo)A1、ApoB、ApoE]水平;采用荧光免疫干式定量法测定hs-CRP ;用凝固法检测FIB ;采用免疫比浊法测定D-二聚体水平。结果与对照组相比,脑梗死患病组TG、LDL-C、ApoA1、ApoE、hs-CRP、D-二聚体及FIB水平均显著升高(P<0.01),而 HDL-C水平则显著降低(P<0.01),TC与A poB水平差异无统计学意义( P>0.05)。结论炎症、血脂、凝血与纤溶系统可相互影响,并与脑梗死的发生和发展关系密切,联合检测有助于辅助诊断脑梗死。%Objective To study the lipids related indicators ,high-sensitivity C-reactive protein(hs-CRP) ,FIB and D-dimer levels in cerebral infarction patients .Methods 259 cerebral infraction patients(cerebral infraction group) and 210 healthy individuals(con-trol group) were enrolled in the study .Plasma lipids related indicators such as TC ,TG ,HDL-C ,LDL-C ,ApoA1 ,ApoB ,ApoE levels were measured by enzymatic colorimetric assay .Quantitative fluorescence immunoassay was used to determine serum level of hs-CRP .FIB levels were determined by using coagulation method ,and D-dimer levels by using immune turbidimetric method .Results Compared with the control group ,the TG ,LDL-C ,ApoA1 ,ApoE and hs-CRP levels were significantly higher in the cerebral infarc-tion group(P0 .05) .Conclusion Lipids ,inflammation ,coagulation and fibrinolysis are closely relat-ed in the development of cerebral infarction ,and combined detection helps diagnose cerebral infarction .

  17. 血清肌酸激酶、C-反应蛋白和D-二聚体水平的测定在绞窄性肠梗阻早期诊断中的应用价值%Application value of level determination of serum creatine kinase, C-reactive protein and D-dimer in the early diagnosis of strangulated intestinal obstruction

    Institute of Scientific and Technical Information of China (English)

    张壮儒; 林楚怀; 杨永怀

    2016-01-01

    Objective: To analyze the value of level determination of serum creatine kinase, C-reactive protein and D-dimer in the early diagnosis of strangulated intestinal obstruction. Methods: 35 cases of strangulating intestinal obstruction patients admitted in our hospital from April 2013 to 2015 April were treated as observation group, and 35 patients admitted during the same period with simple obstruction were taken as the experimental group. Serum creatine kinase, C- reactive protein and D- dimer levels of 30 cases of healthy volunteers were examined as a control group. All patients received serum creatine kinase, C- reactive protein and D- dimer levels measured to compare their test results and analyze the correlation between the three indicators. Results: Compared with the control group, the levels of serum creatine kinase, C- reactive protein and D- dimer were not significantly different (P>0.05), while the serum creatine kinase, C- reactive protein and D- dimer levels of the observation group were significantly higher than those in the experimental group and the control group, the difference was statistically significant (P<0.05). The serum creatine kinase, C-reactive protein and D-dimer levels of the observation group among the three indexes were positively correlated. Conclusion: The detection of serum creatine kinase, C- reactive protein and D- dimer levels can effectively determine the level of strangulating intestinal obstruction, accurately determine the degree of injury patients and provide useful information for the treatment of late stage patients which is worthy of promotion.%目的:分析血清肌酸激酶、C-反应蛋白和 D-二聚体水平的测定在绞窄性肠梗阻早期诊断中的应用价值。方法:选择我院2013年4月—2015年4月收治的35例绞窄性肠梗阻患者作为观察组研究对象,和同期收治的35例单纯性肠梗阻患者作为实验组研究对象,同时,收集我院行血清肌酸激酶、C-反应蛋白

  18. 血浆脑钠肽、肌钙蛋白Ⅰ联合D-二聚体检测在急性肺栓塞中的意义%Clinical Significance of Brain Natriuretic Peptide, Cadiac Troponin Ⅰ, and D-dimer Detection in the Acute Pulmonary Embolism

    Institute of Scientific and Technical Information of China (English)

    耿红霞

    2015-01-01

    目的:探讨急性肺栓塞(APE)患者血浆脑钠肽(BNP)、肌钙蛋白Ⅰ(cTnⅠ)与D-二聚体(D-dimer)水平的临床意义.方法:选取52例APE患者,根据栓塞面积分为大面积APE组与非大面积APE组,测定两组患者的BNP、cTnⅠ、D-二聚体水平、右心功能不全发生率及病死率.结果:大面积APE组BNP、cTnⅠ值显著高于对非大面积APE组,差异有统计学意义(P<0.05),两组D-dimer比较差异无统计学意义(P>0.05);大面积APE患者右心功能不全发生率及病死率(73.1%、26.9%)均显著高于非大面积APE组(15.4%、3.8%),差异有统计学意义(P<0.05).结论:血浆BNP、cTnⅠ水平检测可用于APE患者危险分层及预后评估,D-dimer水平检测可作为诊断APE的排除指标.

  19. Correlation between risk factors of deep vein thrombosis in patients with low-extremitytrauma and plasma D-Dimer%下肢创伤后深静脉血栓形成的危险因素及其与D-二聚体的相关性

    Institute of Scientific and Technical Information of China (English)

    邓淼; 杨渝勇; 曹国永; 李杰

    2014-01-01

    目的 研究下肢创伤后深静脉血栓(deep vein thrombosis,DVT)的发生率、危险因素及D-二聚体(D-Dimer)水平对DVT的诊断价值.方法 回顾性分析我院收治的260例下肢骨折患者的资料,均行彩色多普勒超声检查,以明确有无下肢DVT形成,并统计各类骨折DVT的发生率,对DVT(+)组与DVT(-)组,术前制动时间≥7 d组和术前制动时间<7d组,男性与女性,高龄组与低龄组患者的D-Dimer浓度及DVT的发生率进行统计学分析.结果 下肢骨折总的血栓发生率为12.3%.骨盆骨折中DVT发病率最高(28.57%),足踝部骨折较低(1.54%),创伤后D-Dimer在DVT(+)组的浓度(1527±373)μg/L高于DVT(-)组的(552 ±262) μg/L(P <0.05).结论 下肢骨折DVT的发生率为12.3%.高龄、高凝因素、卧床时间大于7d、吸烟史为DVT的危险因素.D-Dimer浓度正常对排除DVT具有重要意义.且卧床时间等因素对其存在影响.

  20. 半导体激光血管内照射结合电针对血管性痴呆智力及D-二聚体的影响%The Influence of Semiconductor laser Intravascular Irradiation Combined with Electric Acupunture to Vascular Dementia and D-dimer

    Institute of Scientific and Technical Information of China (English)

    莫飞智; 李建强

    2000-01-01

    为探讨激光血管内照射结合电针治疗血管性痴呆(Vascular Dementia,VD)的作用,将90例VD患者按区组随机法分为激光合电针组、电针组和药物组(氢化麦角碱,Dihy-droergotoxine,DHET),每组30例。检测治疗前后长谷川痴呆修改量表(Hasegawa Dementi-a Scale,HDS-R)及血中D-二聚体(D-dimer)的变化情况,共观察6周。结果HDS-R的改善,激光合电针组较电针组及药物组显著。其有效率:激光合电针组66.67%,电针组56.67%,药物组23.33%(P<0.005)。激光合电针组在降低D-二聚体方面较电针组及药物组明显(P<0.05,P<0.005),而电针组与药物组无显著性差异(P>0.05)。结论是,激光合电针法可促进VD患者智能的康复,提高生活质量,其近期疗效优于电针组和药物组。

  1. Expression of ICAM-1, P-selectin, D-dimer in placental tissue and matemal plasm of preeclampsia patients%ICAM-1、P-selectin、D-dimer在子痫前期胎盘和血浆表达研究

    Institute of Scientific and Technical Information of China (English)

    岳永飞; 许多

    2014-01-01

    目的 探讨细胞间黏附分子(ICAM-1)、p-选择素(P-selectin)、D二聚体(D-dimer)在子痫前期发生发展中的作用.方法 随机选取子痫前期患者39例为研究组,37例正常妊娠孕妇为对照组,采用免疫组织化学技术检测两组胎盘组织中ICAM-l、P-selectin的表达情况;采用酶联免疫吸附法(ELISA)检测两组血浆ICAM-1、P-selectin和D-dimer的表达水平.结果 子痫前期组胎盘ICAM-1、P-selectin的表达明显高于对照组(P<0.05);两组血浆均有ICAM-1、P-selectin和D-dimer的表达,子痫前期组的血浆ICAM-1、P-selectin和D-dimer表达明显高于对照组(P<0.05).结论 子痫前期患者ICAM-1、P-selectin和D-dimer表达升高可能与子痫前期的发生发展有关,监测这些指标对病情判断及指导治疗具有重要意义.

  2. Application of body mass index adjusted for fat mass (BMIfat obtained by bioelectrical impedance in adults

    Directory of Open Access Journals (Sweden)

    Mírele Savegnago Mialich

    2014-08-01

    Full Text Available Introduction: Body mass index (BMI has been one of the methods most frequently used for diagnose obesity, but it isn't consider body composition. Objective: This study intends to apply one new adiposity index, the BMI adjusted for fat mass (BMIfat developed by Mialich, et al. (2011, in a adult Brazilian sample. Methods: A cross-sectional study with 501 individuals of both genders (366 women, 135 men aged 17 to 38 years and mean age was 20.4 ± 2.8 years, mean weight 63.0 ± 13.5 kg, mean height 166.9 ± 9.0 cm, and BMI 22.4 ± 3.4 kg/m². Results and discussion: High and satisfactory R2 values were obtained, i.e., 91.1%, 91.9% and 88.8% for the sample as a whole and for men and women, respectively. Considering this BMIfat were developed new ranges, as follows: 1.35 to 1.65 (nutritional risk for malnutrition, > 1.65 and ≤ 2.0 (normal weight and > 2.0 (obesity. The BMIfat had a more accurate capacity of detecting obese individuals (0.980. 0.993, 0.974 considering the sample as a whole and women and men, respectively, compared to the traditional BMI (0.932, 0.956, 0.95. Were also defined new cut-off points for the traditional BMI for the classification of obesity, i.e.: 25.24 kg/m² and 28.38 kg/m² for men and women, respectively. Conclusion: The BMIfat was applied for the present population and can be adopted in clinical practice. Further studies are needed to determine its application to different ethnic groups and to compare this index to others previously described in the scientific literature.

  3. 全髋关节置换术后血浆D-二聚体及纤维蛋白降解产物浓度变化特点的临床意义%Total hip arthroplasty plasma D- dimer and fibrin degradation product concentration changes of clinical significance

    Institute of Scientific and Technical Information of China (English)

    周胜虎; 甄平; 郑宁刚; 高明暄; 田琦; 常彦峰; 李旭升

    2013-01-01

    Objective To investigate the total hip arthroplasty D-dimer (DD) and fibrin degradation products (FDPS) concentration and its effect on the dynamic changes of the early diagnosis of deep venous thrombosis (DVT) value. Methods From July 2011 to May 2012 126 cases of hip replacement patients, their data were retrospectively analyzed, including 56 males and 70 females; aged 38 to 92 years, mean 75.6 years old. According to 7 days after lower extremity B-test results, patients were divided into thrombus group of 32 patients, 94 cases of non-thrombotic group . By immune nephelometry were measured on admission, postoperative 1d, 4d, 7d plasma D-dimer and fibrin degradation products (FDPS) concentration, the relevant test results OK statistical analysis, combined with B-test results, analysis comparison of plasma DD, FDPS two detection index and joint detection sensitivity of the results. Results 126 cases of arthroplasty patients with DD and FDPS values increased in varying degrees postoperatively . Different time points after DD and FDPS plasma concentrations were higher than those without DVT patients, the difference was statistically significant (P<0.05). FDPS after 4, 7 days significantly increased (P<0.01). Compared with baseline in both groups at each time point after DD were significantly increased, peaking at 1 day after surgery : no thrombus group (2469.9±508.3) μg/L, thrombosis group (3472.2 ± 690.7)μg/L (P<0.01);FDPS increased significantly after 4, 7 days and 7 days values increased significantly compared with the value of 4 days:Non-thrombosis group (3673.4±480.7)μg/L, thrombosis group.Conclusion Patients with total hip arthroplasty plasma D-dimer and fibrin degradation product concentration for dynamic monitoring of early diagnosis of DVT has important value.%目的:探讨全髋关节置换术后血浆D-二聚体(DD)及纤维蛋白降解产物(FDPs)浓度的动态变化特点及其对早期诊断下肢深静脉血栓

  4. Metric-adjusted skew information

    DEFF Research Database (Denmark)

    Liang, Cai; Hansen, Frank

    2010-01-01

    We give a truly elementary proof of the convexity of metric-adjusted skew information following an idea of Effros. We extend earlier results of weak forms of superadditivity to general metric-adjusted skew information. Recently, Luo and Zhang introduced the notion of semi-quantum states...... on a bipartite system and proved superadditivity of the Wigner-Yanase-Dyson skew informations for such states. We extend this result to the general metric-adjusted skew information. We finally show that a recently introduced extension to parameter values 1 information is a special case...... of (unbounded) metric-adjusted skew information....

  5. Convexity Adjustments for ATS Models

    DEFF Research Database (Denmark)

    Murgoci, Agatha; Gaspar, Raquel M.

    Practitioners are used to value a broad class of exotic interest rate derivatives simply by preforming for what is known as convexity adjustments (or convexity corrections). We start by exploiting the relations between various interest rate models and their connections to measure changes. As a re......Practitioners are used to value a broad class of exotic interest rate derivatives simply by preforming for what is known as convexity adjustments (or convexity corrections). We start by exploiting the relations between various interest rate models and their connections to measure changes....... As a result we classify convexity adjustments into forward adjustments and swaps adjustments. We, then, focus on affine term structure (ATS) models and, in this context, conjecture convexity adjustments should be related of affine functionals. In the case of forward adjustments, we show how to obtain exact...... formulas. Concretely for LIBOR in arrears (LIA) contracts, we derive the system of Riccatti ODE-s one needs to compute to obtain the exact adjustment. Based upon the ideas of Schrager and Pelsser (2006) we are also able to derive general swap adjustments useful, in particular, when dealing with constant...

  6. Adjustment computations spatial data analysis

    CERN Document Server

    Ghilani, Charles D

    2011-01-01

    the complete guide to adjusting for measurement error-expanded and updated no measurement is ever exact. Adjustment Computations updates a classic, definitive text on surveying with the latest methodologies and tools for analyzing and adjusting errors with a focus on least squares adjustments, the most rigorous methodology available and the one on which accuracy standards for surveys are based. This extensively updated Fifth Edition shares new information on advances in modern software and GNSS-acquired data. Expanded sections offer a greater amount of computable problems and their worked solu

  7. Adjusting CA19-9 values to predict malignancy in obstructive jaundice: Influence of bilirubin and C-reactive protein

    Institute of Scientific and Technical Information of China (English)

    Gaetano La Greca; Maria Sofia; Rosario Lombardo; Saverio Latteri; Agostino Ricotta; Stefano Puleo; Domenico Russello

    2012-01-01

    AIM:To find a possible relationship between inflammation and CA19-9 tumor marker by analyzing data from patients with benign jaundice (BJ) and malignant jaundice (MJ).METHODS:All patients admitted for obstructive jaundice,in the period 2005-2009,were prospectively enrolled in the study,obtaining a total of 102 patients.On admission,all patients underwent complete standard blood test examinations including C-reactive protein (CRP),bilirubin,CA19-9.Patients were considered eligible for the study when they presented obstructive jaundice confirmed by instrumental examinations and increased serum bilirubin levels (total bilirubin > 2.0 mg/dL).The standard cut-off level for CA19-9 was 32 U/mL,whereas for CRP this was 1.5 mg/L.The CA19-9 level was adjusted by dividing it by the value of serum bilirubin or by the CRP value.The patients were divided into 2 groups,MJ and BJ,and after the adjustment a comparison between the 2 groups of patients was performed.Sensitivity,specificity and positive predictive values were calculated before and after the adjustment.RESULTS:Of the 102 patients,51 were affected by BJ and 51 by MJ.Pathologic CA19-9 levels were found in 71.7% of the patients.In the group of 51 BJ patients there were 29 (56.9%) males and 22 (43.1%) females with a median age of 66 years (range 24-96 years),whereas in the MJ group there were 24 (47%) males and 27 (53%) females,with a mean age of 70 years (range 30-92 years).Pathologic CA19-9 serum level was found in 82.3% of MJ.CRP levels were pathologic in 66.6% of the patients with BJ and in 49% with MJ.Bilirubin and CA19-9 average levels were significantly higher in MJ compared with BJ (P =0.000 and P =0.02),while the CRP level was significantly higher in BJ (P =0.000).Considering a CA19-9 cut-off level of 32 U/mL,82.3% in the MJ group and 54.9% in the BJ group were positive for CA19-9 (P =0.002).A CA19-9 cut-off of 100 U/mL increases the difference between the two groups:35.3% in BJ and 68.6

  8. Spousal Adjustment to Myocardial Infarction.

    Science.gov (United States)

    Ziglar, Elisa J.

    This paper reviews the literature on the stresses and coping strategies of spouses of patients with myocardial infarction (MI). It attempts to identify specific problem areas of adjustment for the spouse and to explore the effects of spousal adjustment on patient recovery. Chapter one provides an overview of the importance in examining the…

  9. Mood Adjustment via Mass Communication.

    Science.gov (United States)

    Knobloch, Silvia

    2003-01-01

    Proposes and experimentally tests mood adjustment approach, complementing mood management theory. Discusses how results regarding self-exposure across time show that patterns of popular music listening among a group of undergraduate students differ with initial mood and anticipation, lending support to mood adjustment hypotheses. Describes how…

  10. A complete generalized adjustment criterion

    NARCIS (Netherlands)

    Perković, Emilija; Textor, Johannes; Kalisch, Markus; Maathuis, Marloes H.

    2015-01-01

    Covariate adjustment is a widely used approach to estimate total causal effects from observational data. Several graphical criteria have been developed in recent years to identify valid covariates for adjustment from graphical causal models. These criteria can handle multiple causes, latent confound

  11. Bayes linear covariance matrix adjustment

    CERN Document Server

    Wilkinson, Darren J

    1995-01-01

    In this thesis, a Bayes linear methodology for the adjustment of covariance matrices is presented and discussed. A geometric framework for quantifying uncertainties about covariance matrices is set up, and an inner-product for spaces of random matrices is motivated and constructed. The inner-product on this space captures aspects of our beliefs about the relationship between covariance matrices of interest to us, providing a structure rich enough for us to adjust beliefs about unknown matrices in the light of data such as sample covariance matrices, exploiting second-order exchangeability and related specifica