Sample records for additional delayed regional

  1. Effects of additional food in a delayed predator-prey model.

    Sahoo, Banshidhar; Poria, Swarup


    We examine the effects of supplying additional food to predator in a gestation delay induced predator-prey system with habitat complexity. Additional food works in favor of predator growth in our model. Presence of additional food reduces the predatory attack rate to prey in the model. Supplying additional food we can control predator population. Taking time delay as bifurcation parameter the stability of the coexisting equilibrium point is analyzed. Hopf bifurcation analysis is done with respect to time delay in presence of additional food. The direction of Hopf bifurcations and the stability of bifurcated periodic solutions are determined by applying the normal form theory and the center manifold theorem. The qualitative dynamical behavior of the model is simulated using experimental parameter values. It is observed that fluctuations of the population size can be controlled either by supplying additional food suitably or by increasing the degree of habitat complexity. It is pointed out that Hopf bifurcation occurs in the system when the delay crosses some critical value. This critical value of delay strongly depends on quality and quantity of supplied additional food. Therefore, the variation of predator population significantly effects the dynamics of the model. Model results are compared with experimental results and biological implications of the analytical findings are discussed in the conclusion section.

  2. Formation of "delayed risks" in regional innovative production

    Olga Avdeychik


    Full Text Available The article considers specific features of functioning of regional complexes within the framework of joint realization of both Sustainable Development Concept and an innovation strategy which provides a synergistic result of achieving optimal economic parameters while minimizing negative anthropogenic impact on the environment. Violation of the optimal equilibrium in the simultaneous implementation of both strategies increases the probability of manifestation of environmental and economic risks and economic risks, due to increasing share of waste at different stages of life cycle of industrial products with a predominant innovation component. Disproportions in the implementation of modern approaches to innovations functioning with regard to regional specifics of sustainable development increase adverse effects on the ecosystem. Forming a background of delayed technologic and environmental risk, they increase the likelihood of economic risk, reducing the effectiveness of already implemented innovations. An effective strategy for minimization of delayed risks to different species is the formation of regional cluster structures which include industrial, managerial, research and training components based on integration of intellectual, material and technological resources.

  3. Robust H∞ control of uncertain systems with two additive time-varying delays

    Syed, Ali M.; Saravanakumar, R.


    This paper is concerned with the problem of delay-dependent robust H∞ control for a class of uncertain systems with two additive time-varying delays. A new suitable Lyapunov-Krasovskii functional (LKF) with triple integral terms is constructed and a tighter upper bound of the derivative of the LKF is derived. By applying a convex optimization technique, new delay-dependent robust H∞ stability criteria are derived in terms of linear matrix inequalities (LMI). Based on the stability criteria, a state feedback controller is designed such that the closed-loop system is asymptotically stable. Finally, numerical examples are given to illustrate the effectiveness of the proposed method. Comparison results show that our results are less conservative than the existing methods. Project supported by the Fund from the Department of Science and Technology of India (Grant No. SR/FTP/MS-039/2011).




    is no effect of Tramadol on onset of motor blocked in both the group. In post - operative period the need of analgesic is delayed in group 2 which is statistically significant.( p value is 0.00001 We observe post - oper ative nausea and vomiting events more in group - 1(24% and in group - 2 (16 % but there isno statistical difference. Pain is the significant factor for post - operative nausea and vomiting. Group 2 patients (Tramadol group are more comfortable with tourniquet intra - operatively but statistically it is not significant. Intraoperative discomfort may attribute to anxiety and fear along with possibility of dilution of drugs because of inadequate exsanguination . CONCLUSION : We conclude that addition of injection Tra madol 50mg in intravenous regional anesthesia will improve the onset of sensory blockade and improves the post - operative analgesia without any increase of postoperative nausea and vomiting. Also it is concluded that injection Tramadol has no effect on moto r blocked.

  5. Mixed butanols addition to gasoline surrogates: Shock tube ignition delay time measurements and chemical kinetic modeling

    AlRamadan, Abdullah S.


    The demand for fuels with high anti-knock quality has historically been rising, and will continue to increase with the development of downsized and turbocharged spark-ignition engines. Butanol isomers, such as 2-butanol and tert-butanol, have high octane ratings (RON of 105 and 107, respectively), and thus mixed butanols (68.8% by volume of 2-butanol and 31.2% by volume of tert-butanol) can be added to the conventional petroleum-derived gasoline fuels to improve octane performance. In the present work, the effect of mixed butanols addition to gasoline surrogates has been investigated in a high-pressure shock tube facility. The ignition delay times of mixed butanols stoichiometric mixtures were measured at 20 and 40bar over a temperature range of 800-1200K. Next, 10vol% and 20vol% of mixed butanols (MB) were blended with two different toluene/n-heptane/iso-octane (TPRF) fuel blends having octane ratings of RON 90/MON 81.7 and RON 84.6/MON 79.3. These MB/TPRF mixtures were investigated in the shock tube conditions similar to those mentioned above. A chemical kinetic model was developed to simulate the low- and high-temperature oxidation of mixed butanols and MB/TPRF blends. The proposed model is in good agreement with the experimental data with some deviations at low temperatures. The effect of mixed butanols addition to TPRFs is marginal when examining the ignition delay times at high temperatures. However, when extended to lower temperatures (T < 850K), the model shows that the mixed butanols addition to TPRFs causes the ignition delay times to increase and hence behaves like an octane booster at engine-like conditions. © 2015 The Combustion Institute.

  6. A Modified Time-Delay Addition Method to Extract Resistive Leakage Current of MOSA

    Khodsuz, Masume; Mirzaie, Mohammad


    Metal oxide surge arresters are one of the most important equipment for power system protection against switching and lightning over-voltages. High-energy stresses and environmental features are the main factors which degrade surge arresters. In order to verify surge arresters good condition, their monitoring is necessary. The majority of surge arrester monitoring techniques is based on total leakage current decomposition of their capacitive and resistive components. This paper introduces a new approach based on time-delay addition method to extract the resistive current from the total leakage current without measuring voltage signal. Surge arrester model for calculating leakage current has been performed in ATP-EMTP. In addition, the signal processing has been done using MATLAB software. To show the accuracy of the proposed method, experimental tests have been performed to extract resistive leakage current by the proposed method.

  7. Fokker-Planck description for a linear delayed Langevin equation with additive Gaussian noise

    Giuggioli, Luca; McKetterick, Thomas John; Kenkre, V. M.; Chase, Matthew


    We construct an equivalent probability description of linear multi-delay Langevin equations subject to additive Gaussian white noise. By exploiting the time-convolutionless transform and a time variable transformation we are able to write a Fokker-Planck equation (FPE) for the 1-time and for the 2-time probability distributions valid irrespective of the regime of stability of the Langevin equations. We solve exactly the derived FPEs and analyze the aging dynamics by studying analytically the conditional probability distribution. We discuss explicitly why the initially conditioned distribution is not sufficient to describe fully out a non-Markov process as both preparation and observation times have bearing on its dynamics. As our analytic procedure can also be applied to linear Langevin equations with memory kernels, we compare the non-Markov dynamics of a one-delay system with that of a generalized Langevin equation with an exponential as well as a power law memory. Application to a generalization of the Green-Kubo formula is also presented.

  8. β-delayed proton emission in the 100Sn region

    Lorusso, G.; Becerril, A.; Amthor, A.; Baumann, T.; Bazin, D.; Berryman, J. S.; Brown, B. A.; Cyburt, R. H.; Crawford, H. L.; Estrade, A.; Gade, A.; Ginter, T.; Guess, C. J.; Hausmann, M.; Hitt, G. W.; Mantica, P. F.; Matos, M.; Meharchand, R.; Minamisono, K.; Montes, F.; Perdikakis, G.; Pereira, J.; Portillo, M.; Schatz, H.; Smith, K.; Stoker, J.; Stolz, A.; Zegers, R. G. T.


    β-delayed proton emission from nuclides in the neighborhood of 100Sn was studied at the National Superconducting Cyclotron Laboratory (NSCL). The nuclei were produced by fragmentation of a 120 MeV/nucleon 112Sn primary beam on a Be target. Beam purification was provided by the A1900 Fragment Separator and the Radio Frequency Fragment Separator. The fragments of interest were identified and their decay was studied with the NSCL Beta Counting System in conjunction with the Segmented Germanium Array. The nuclei 96Cd, 98Ing, 98Inm, and 99In were identified as β-delayed proton emitters, with branching ratios bβp=5.5(40)%, 5.5-2+3%, 19(2)%, and 0.9(4)%, respectively. The branching ratios for 89Ru, 91,92Rh, 93Pd, and 95Ag were deduced for the first time with bβp=3-1.7+1.9%, 1.3(5)%, 1.9(1)%, 7.5(5)%, and 2.5(3)%, respectively. The bβp=22(1)% value for 101Sn was deduced with higher precision than previously reported. The impact of the newly measured bβp values on the composition of the type I x-ray burst ashes was studied.

  9. Beta-delayed proton emission in the 100Sn region

    Lorusso, G; Amthor, A; Baumann, T; Bazin, D; Berryman, J S; Brown, B A; Cyburt, R H; Crawford, H L; Estrade, A; Gade, A; Ginter, T; Guess, C J; Hausmann, M; Hitt, G W; Mantica, P F; Matos, M; Meharchand, R; Minamisono, K; Montes, F; Perdikakis, G; Pereira, J; Portillo, M; Schatz, H; Smith, K; Stoker, J; Stolz, A; Zegers, R G T


    Beta-delayed proton emission from nuclides in the neighborhood of 100Sn was studied at the National Superconducting Cyclotron Laboratory. The nuclei were produced by fragmentation of a 120 MeV/nucleon 112Sn primary beam on a Be target. Beam purification was provided by the A1900 Fragment Separator and the Radio Frequency Fragment Separator. The fragments of interest were identified and their decay was studied with the NSCL Beta Counting System (BCS) in conjunction with the Segmented Germanium Array (SeGA). The nuclei 96Cd, 98Ing, 98Inm and 99In were identified as beta-delayed proton emitters, with branching ratios bp = 5.5(40)%, 5.5+3 -2%, 19(2)% and 0.9(4)%, respectively. The bp for 89Ru, 91,92Rh, 93Pd and 95Ag were deduced for the first time with bp = 3+1.9 -1.7%, 1.3(5)%, 1.9(1)%, 7.5(5)% and 2.5(3)%, respectively. The bp = 22(1)% for 101Sn was deduced with higher precision than previously reported. The impact of the newly measured bp values on the composition of the type-I X-ray burst ashes was studied.

  10. Identification and systematical studies of the electron-capture delayed fission (ECDF) in the lead region

    Pauwels, D B; Lane, J


    In our recent experiment (March 2007) at the velocity filter SHIP(GSI) we observed the electron-capture delayed fission of the odd-odd isotope $^{194}$At. This is the first unambiguous identification of this phenomenon in the very neutron-deficient nuclei in the vicinity of the proton shell closure at Z=82. In addition, the total kinetic energy (TKE) for the daughter nuclide $^{194}$Po was measured, despite the fact that this isotope does not decay via spontaneous fission. Semi-empirical analysis of the electron-capture Q$_{EC}$ values and fission barriers B$_{f}$ shows that a relatively broad island of ECDF must exist in this region of the Nuclide Chart, with some of the nuclei having unusually high ECDF probabilities. Therefore, this Proposal is intended to initiate the systematic identification and study of $\\beta$-delayed fission at ISOLDE in the very neutron-deficient lead region. Our aim is to provide unique low-energy fission data (e.g. probabilities, TKE release, fission barriers and their isospin dep...

  11. Searching for additional disease loci in a genomic region.

    Thomson, Glenys; Barcellos, Lisa F; Valdes, Ana M


    Our aim is to review methods to optimize detection of all disease genes in a genetic region. As a starting point, we assume there is sufficient evidence from linkage and/or association studies, based on significance levels or replication studies, for the involvement in disease risk of the genetic region under study. For closely linked markers, there will often be multiple associations with disease, and linkage analyses identify a region rather than the specific disease-predisposing gene. Hence, the first task is to identify the primary (major) disease-predisposing gene or genes in a genetic region, and single nucleotide polymorphisms thereof, that is, how to distinguish true associations from those that are just due to linkage disequilibrium with the actual disease-predisposing variants. Then, how do we detect additional disease genes in this genetic region? These two issues are of course very closely interrelated. No existing programs, either individually or in aggregate, can handle the magnitude and complexity of the analyses needed using currently available methods. Further, even with modern computers, one cannot study every possible combination of genetic markers and their haplotypes across the genome, or even within a genetic region. Although we must rely heavily on computers, in the final analysis of multiple effects in a genetic region and/or interaction or independent effects between unlinked genes, manipulation of the data by the individual investigator will play a crucial role. We recommend a multistrategy approach using a variety of complementary methods described below.

  12. An LMI Approach to H∞ Performance Analysis of Continous-Time System with Two Additive Time-Varying Delays

    Wrastawa Ridwan


    Full Text Available This paper investigates the problem of H∞ performance analysis for continous–time systems with two additive time-varying delays in the state. Our objective is focused on stability analysis of a continuous system with two time-varying delays with an H∞ disturbance attenuation level γ. By exploiting Lyapunov-Krasovski functional and introducing free weighting matrix variables, LMI stability condition have been derived.

  13. Subchronic delayed neurotoxicity evaluation of jet engine lubricants containing phosphorus additives.

    Daughtrey, W; Biles, R; Jortner, B; Ehrich, M


    Synthetic polyol-based lubricating oils containing 3% of either commercial tricresyl phosphate (TCP), triphenylphosphorothionate (TPPT), or butylated triphenyl phosphate (BTP) additive were evaluated for neurotoxicity in the adult hen using clinical, biochemical, and neuropathological endpoints. Groups of 17-20 hens were administered the oils by oral gavage at a "limit dose" of 1 g/kg, 5 days a week for 13 weeks. A group of positive control hens was included which received 7.5 mg/kg of one isomer of TCP (tri-ortho-cresyl phosphate, TOCP) on the same regimen, with an additional oral dose of 500 mg/kg given 12 days before the end of the experiment. A negative control group received saline. Neurotoxic esterase (NTE) activity in brain and spinal cord of hens dosed with the lubricating oils was not significantly different from saline controls after 6 weeks of treatment. After 13 weeks of dosing, NTE was inhibited 23 to 34% in brains of lubricant-treated hens. Clinical assessments of walking ability did not indicate any differences between the negative control group and lubricant-treated hens. Moreover, neuropathological examination revealed no alterations indicative of organophosphorus-induced delayed neuropathy (OPIDN). In hens treated with the positive control, significant inhibition of NTE was observed in brain and spinal cord at both 6 and 13 weeks of dosing; this group also demonstrated clinical impairment and pathological lesions indicative of OPIDN. In conclusion, the results of the present study indicated that synthetic polyol-based lubricating oils containing up to 3% TCP, TPPT, or BTP had low neurotoxic potential and should not pose a hazard under realistic conditions of exposure.

  14. Stability Region Analysis of PID and Series Leading Correction PID Controllers for the Time Delay Systems



    Full Text Available This paper describes the stability regions of PID (Proportional +Integral+ Derivative and a new PID with series leading correction (SLC for Networked control system with time delay. The new PID controller has a tuning parameter ‘β’. The relation between β, KP, KI and KD is derived. The effect of plant parameters on stabilityregion of PID controllers and SLC-PID controllers in first-order and second-order systems with time delay are also studied. Finally, an open-loop zero was inserted into the plant-unstable second order system with time delay so that the stability regions of PID and SLC-PID controllers get effectively enlarged. The total system isimplemented using MATLAB/Simulink.

  15. Delayed onset of tricuspid valve flow in repaired tetralogy of Fallot: an additional mechanism of diastolic dysfunction and interventricular dyssynchrony

    Benson Lee N


    Full Text Available Abstract Background Diastolic dysfunction of the right ventricle (RV is common after repair of tetralogy of Fallot. While restrictive physiology in late diastole has been well known, dysfunction in early diastole has not been described. The present study sought to assess the prevalence and mechanism of early diastolic dysfunction of the RV defined as delayed onset of the tricuspid valve (TV flow after TOF repair. Methods The study population consisted of 31 children with repaired TOF (mean age ± SD, 12.3 ± 4.1 years who underwent postoperative cardiovascular magnetic resonance (CMR. The CMR protocol included simultaneous phase-contrast velocity mapping of the atrioventricular valves, which enabled direct comparison of the timing and patterns of tricuspid (TV and mitral (MV valve flow. The TV flow was defined to have delayed onset when its onset was > 20 ms later than the onset of the MV flow. The TV and MV flow from 14 normal children was used for comparison. The CMR results were correlated with the findings on echocardiography and electrocardiography. Result Delayed onset of the TV flow was observed in 16/31 patients and in none of the controls. The mean delay time was 64.81 ± 27.07 ms (8.7 ± 3.2% of R-R interval. The delay time correlated with the differences in duration of the TV and MV flow (55.94 ± 32.88 ms (r = 0.90, p Conclusions Early diastolic dysfunction with delayed onset of TV flow is common after TOF repair, and is associated with reduced RV ejection fraction. It is a further manifestation of interventricular dyssynchrony and represent an additional mechanism of ventricular diastolic dysfunction.

  16. Batch arrival retrial queue with delay time and additional multi-optional repair

    D. Sumitha


    Full Text Available This paper deals with MX/G/1 retrial queue with unreliable server and multi-optional repair. It is assumed that the server is subject to active breakdowns and the repair of the failed server starts after a random amount of time. Restoration of the failed server is done with two phases, first essential and second multi optional. After completion of the repair the server continues the interrupted service and it is not allowed to accept new customers until the interrupted customer leaves the system. The retrial, service, delay and repair times are arbitrarily distributed. The model is analysed using the supplementary variable technique and the probability generating function of system size at random epoch and stochastic decomposition are obtained. Performance measures and reliability indices to predict the behaviour of the system are derived.

  17. Delayed addition of nitrogen-rich substrates during composting of municipal waste

    Nigatu, Abebe Nigussie; Bruun, Sander; Kuyper, Thomas W.;


    Municipal waste is usually composted with an N-rich substrate, such as manure, to increase the N content of the product. This means that a significant amount of nitrogen can be lost during composting. The objectives of this study were (i) to investigate the effect of split addition of a nitrogen......-rich substrate (poultry manure) on nitrogen losses and greenhouse gas emissions during composting and to link this effect to different bulking agents (coffee husks and sawdust), and (ii) to assess the effect of split addition of a nitrogen-rich substrate on compost stability and sanitisation. The results showed...... addition increased methane emissions by up to 50% compared to split addition of the substrate. Hence, the timing of the addition of the N-rich substrate had only a marginal effect on total non-CO2 greenhouse gas emissions. Split addition of the N-rich substrate resulted in compost that was just as stable...

  18. Achievable Rate Regions for the Causal Cognitive Interference Channel With Delay

    Mirmohseni, Mahtab; Aref, Mohammad Reza


    In this paper, we introduce the Causal Cognitive Interference Channel With Delay (CC-IFC-WD) in which the cognitive user transmission can depend on the L future received symbols as well as the past ones. Taking the effect of the link delays into account, CC-IFC-WD fills the gap between the genie-aided and causal cognitive radio channels. We study three special cases: 1)Classical CC-IFC (L=0), 2)CC-IFC without delay (L=1) and 3)CC-IFC with a block length delay (L=n). In each situation, we obtain an inner bound on the capacity region. Our coding schemes make use of cooperative strategy by generalized block Markov superposition coding, collaborative strategy by rate splitting, and Gel'fand-Pinsker coding in order to pre-cancel part of the interference. Moreover, instantaneous relaying and non-causal partial Decode-and-Forward are employed in the second and third cases, respectively. The derived achievable rate regions under special conditions, reduce to several previously known ones.

  19. Calibration of regional ionospheric delay with uncombined precise point positioning and accuracy assessment

    Li Wei; Cheng Pengfei; Bei Jinzhong; Wen Hanjiang; Wang Hua


    A new method for the calibration of regional ionospheric delay based on uncombined precise point positioning (U-PPP) is proposed in this study. The performance of the new method was comparatively validated in terms of its accuracy and robustness with respect to the phase-smoothed pseudorange (PSP) method through two short-baseline experiments. Accuracy of the PPP-derived ionospheric delays was further assessed by interpolating them to a user station to perform single-frequency simulated kinematic PPP. Two 24-hr period datasets of four continuous operation reference system (CORS) stations were analyzed, collected during calm and disturbed ionospheric conditions, respectively. The single-frequency GPS observables from a user station, that were a-priori corrected by the interpolated ionospheric delays, were utilized to implement single-frequency PPP (SF-PPP). The results show that interpolation accuracy is better than 1 dm and, with the proposed method, is less affected by the ionospheric activity; meanwhile, positioning accuracy of SF-PPP was 4 ∼5 cm (horizontal) and better than 1 dm (vertical). For comparison, two reference SF-PPP solutions were also obtained, in which the ionospheric delays are eliminated either by forming semi-combination observations or by using global ionosphere maps (GIM) model values; in both cases the positioning accuracy was only 4 ∼7 dm (horizontal) and 1 m (vertical). These results provide a further demonstration of the performance of PPP-based regional ionospheric calibration in the parameter domain.

  20. Delayed ENSO impact on spring precipitation over North/Atlantic European region

    Herceg Bulic, Ivana [Faculty of Science, University of Zagreb, Andrija Mohorovicic Geophysical Institute, Department of Geophysics, Zagreb (Croatia); Kucharski, Fred [Abdus Salam International Centre for Theoretical Physics, Earth System Physics Section, Trieste (Italy)


    The delayed impact of winter sea-surface temperature (SST) anomalies in tropical Pacific on spring precipitation over the North Atlantic/European (NAE) region is examined using both measured and modeled data for the period 1901-2002. In an AMIP-type Atmospheric General Circulation Model (AGCM) ensemble, the observed delayed spring precipitation response in Europe to winter ENSO-related SST anomalies is well reproduced. A series of targeted AGCM/coupled GCM experiments are performed to further investigate the mechanisms for this delayed influence. It is found that late winter ENSO SST anomalies lead to the well-documented Rossby wave train arching from the Pacific into the Atlantic region. A positive (negative) ENSO event leads to a quasi-barotropic trough (ridge) in the North Atlantic region. The resulting wind and cloud changes cause anomalies in the surface heat fluxes that result in negative (positive) SST anomalies in the central North Atlantic and anomalies of the opposite sign further to the south. The SST anomalies persist into spring and the atmospheric response to these anomalies is an extension of the ENSO-induced trough (ridge) into the European region, leading to enhanced (reduced) moisture flux and low-level convergence (divergence) and thus positive (negative) precipitation anomalies. Although the signal is overall relatively weak (correlation coefficients of European spring rainfall with winter ENSO SSTs of about 0.3), a proper representation of the outlined mechanism in seasonal forecasting systems may lead to improved seasonal predictions. (orig.)

  1. Effects of time delay on stochastic resonance of a periodically driven linear system with multiplicative and periodically modulated additive white noises

    Du Lu-Chun; Mei Dong-Cheng


    Stochastic resonance (SR) of a periodically driven time-delayed linear system with multiplicative white noise and periodically modulated additive white noise is investigated. In the condition of small delay time, an approximate analytical expression of output signal-to-noise ratio (SNR) is obtained. The analytical results indicate that (1) there exists a resonance peak in the curve for SNR versus time delay; (2) the time delay will suspend the SR dramatically for SNR versus other parameters of the system, such as noise intensity, correlation intensity, and signal frequency, once a certain value is reached, the SR phenomenon disappears.

  2. Delayed Proton Emission in the A=70 Region, a Strobe for Level Density and Particle Width


    The delayed particle emission, which is a characteristic signature of the most exotic nuclei decay, provides a wide variety of spectroscopic information among which level density, and gives in some cases access to selected microscopic structures. In regard to these two aspects the $\\beta^+$-EC delayed proton emission in the A=70 neutron deficient mass region is of special interest to be investigated. Indeed, in this area located close to the proton drip line and along the N=Z line, the delayed proton emission constitutes an access to level density in the Q$_{EC}$-S$_p$ window of the emitting nucleus. Moreover, the unbound states populated by the EC process are expected to exhibit lifetimes in the vicinity of the K electronic shell filling time ($\\tau\\!\\sim\\!2\\times10^{-16}$s) and so the particle widths can be reached via proton X-ray coincidence measurements (PXCT). From theoretical approaches strongly deformed low-spin proton unbound levels which may be populated in the T$_Z$ = 1/2 precursors decay are predi...

  3. Increased risk of schizophrenia from additive interaction between infant motor developmental delay and obstetric complications: evidence from a population-based longitudinal study.

    Clarke, Mary C


    Obstetric complications and developmental delay are well-established risk factors for schizophrenia. The authors investigated whether these risk factors interact in an additive manner to further increase risk for schizophrenia.

  4. Delay-Induced Triple-Zero Bifurcation in a Delayed Leslie-Type Predator-Prey Model with Additive Allee Effect

    Jiang, Jiao; Song, Yongli; Yu, Pei


    In this paper, a Leslie-type predator-prey model with ratio-dependent functional response and Allee effect on prey is considered. We first study the existence of the multiple positive equilibria and their stability. Then we investigate the effect of delay on the distribution of the roots of characteristic equation and obtain the conditions for the occurrence of simple-zero, double-zero and triple-zero singularities. The formulations for calculating the normal form of the triple-zero bifurcation of the delay differential equations are derived. We show that, under certain conditions on the parameters, the system exhibits homoclinic orbit, heteroclinic orbit and periodic orbit.

  5. Genetic Otx2 mis-localization delays critical period plasticity across brain regions.

    Lee, H H C; Bernard, C; Ye, Z; Acampora, D; Simeone, A; Prochiantz, A; Di Nardo, A A; Hensch, T K


    Accumulation of non-cell autonomous Otx2 homeoprotein in postnatal mouse visual cortex (V1) has been implicated in both the onset and closure of critical period (CP) plasticity. Here, we show that a genetic point mutation in the glycosaminoglycan recognition motif of Otx2 broadly delays the maturation of pivotal parvalbumin-positive (PV+) interneurons not only in V1 but also in the primary auditory (A1) and medial prefrontal cortex (mPFC). Consequently, not only visual, but also auditory plasticity is delayed, including the experience-dependent expansion of tonotopic maps in A1 and the acquisition of acoustic preferences in mPFC, which mitigates anxious behavior. In addition, Otx2 mis-localization leads to dynamic turnover of selected perineuronal net (PNN) components well beyond the normal CP in V1 and mPFC. These findings reveal widespread actions of Otx2 signaling in the postnatal cortex controlling the maturational trajectory across modalities. Disrupted PV+ network function and deficits in PNN integrity are implicated in a variety of psychiatric illnesses, suggesting a potential global role for Otx2 function in establishing mental health.Molecular Psychiatry advance online publication, 14 February 2017; doi:10.1038/mp.2017.1.

  6. Reactive changes in astrocytes, and delayed neuronal death, in the rat hippocampal CA1 region following cerebral ischemia/reperfusion

    Guiqing Zhang; Xiang Luo; Zhiyuan Yu; Chao Ma; Shabei Xu; Wei Wang


    BACKGROUND: Blood supply to the hippocampus is not provided by the middle cerebral artery. However, previous studies have shown that delayed neuronal death in the hippocampus may occur following focal cerebral ischemia induced by middle cerebral artery occlusion. OBJECTIVE: To observe the relationship between reactive changes in hippocampal astrocytes and delayed neuronal death in the hippocampal CA1 region following middle cerebral artery occlusion. DESIGN, TIME AND SETTING: The immunohistochemical, randomized, controlled animal study was performed at the Laboratory of Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, from July to November 2007. MATERIALS: Rabbit anti-glial fibrillary acidic protein (GFAP) (Neomarkers, USA), goat anti-rabbit IgG (Sigma, USA) and ApoAlert apoptosis detection kit (Biosciences Clontech, USA) were used in this study. METHODS: A total of 42 healthy adult male Wistar rats, aged 3-5 months, were randomly divided into a sham operation group (n = 6) and a cerebral ischemia/reperfusion group (n = 36). In the cerebral ischemia/reperfusion group, cerebral ischemia/reperfusion models were created by middle cerebral artery occlusion. In the sham operation group, the thread was only inserted into the initial region of the internal carotid artery, and middle cerebral artery occlusion was not induced. Rats in the cerebral ischemia/reperfusion group were assigned to a delayed neuronal death (+) subgroup and a delayed neuronal death (-) subgroup, according to the occurrence of delayed neuronal death in the ischemic side of the hippocampal CA1 region following cerebral ischemia. MAIN OUTCOME MEASURES: Delayed neuronal death in the hippocampal CA1 region was measured by Nissl staining. GFAP expression and delayed neuronal death changes were measured in the rat hippocampal CA1 region at the ischemic hemisphere by double staining for GFAP and TUNEL. RESULTS: After 3 days of ischemia

  7. $\\beta$-delayed fission in proton-rich nuclei in the lead region

    AUTHOR|(CDS)2085005; Huyse, Mark; Popescu, Lucia

    Nuclear fission is the breakup of an atomic nucleus into two (sometimes three) fragments, thereby releasing a large amount of energy. Soon after its discovery in the late 1930’s, the gross properties of the fission phenomenon were explained by macroscopic nuclear models. Certain features however, such as asymmetric fission-fragment mass distributions in the actinide region, require the inclusion of microscopic effects. This interplay of the microscopic motion of individual nucleons on this macroscopic process is, until today, not yet fully understood. The phenomenon of fission has therefore been of recurring interest for both theoretical and experimental studies. This thesis work focuses on the $\\beta$-delayed fission ($\\beta$DF) process, an excellent tool to study low-energy fission of exotic nuclei, which was discovered in 1966 in the actinide region. In this two-step process, a precursor nucleus first undergoes $\\beta$-decay to an excited level in the daughter nucleus, which may subsequently fission. Rec...

  8. Combined action of time-delay and colored cross-associated multiplicative and additive noises on stability and stochastic resonance for a stochastic metapopulation system

    Wang, Kang-Kang; Zong, De-Cai; Wang, Ya-Jun; Li, Sheng-Hong


    In this paper, the transition between the stable state of a big density and the extinction state and stochastic resonance (SR) for a time-delayed metapopulation system disturbed by colored cross-correlated noises are investigated. By applying the fast descent method, the small time-delay approximation and McNamara and Wiesenfeld's SR theory, we investigate the impacts of time-delay, the multiplicative, additive noises and colored cross-correlated noise on the SNR and the shift between the two states of the system. Numerical results show that the multiplicative, additive noises and time-delay can all speed up the transition from the stable state to the extinction state, while the correlation noise and its correlation time can slow down the extinction process of the population system. With respect to SNR, the multiplicative noise always weakens the SR effect, while noise correlation time plays a dual role in motivating the SR phenomenon. Meanwhile, time-delay mainly plays a negative role in stimulating the SR phenomenon. Conversely, it could motivate the SR effect to increase the strength of the cross-correlation noise in the SNR-β plot, while the increase of additive noise intensity will firstly excite SR, and then suppress the SR effect.

  9. Vascular Steal Explains Early Paradoxical Blood Oxygen Level-Dependent Cerebrovascular Response in Brain Regions with Delayed Arterial Transit Times

    Julien Poublanc


    Full Text Available Introduction: Blood oxygen level-dependent (BOLD magnetic resonance imaging (MRI during manipulation of inhaled carbon dioxide (CO2 can be used to measure cerebrovascular reactivity (CVR and map regions of exhausted cerebrovascular reserve. These regions exhibit a reduced or negative BOLD response to inhaled CO2. In this study, we sought to clarify the mechanism behind the negative BOLD response by investigating its time delay (TD. Dynamic susceptibility contrast (DSC MRI with the injection of a contrast agent was used as the gold standard in order to provide measurement of the blood arrival time to which CVR TD could be compared. We hypothesize that if negative BOLD responses are the result of a steal phenomenon, they should be synchronized with positive BOLD responses from healthy brain tissue, even though the blood arrival time would be delayed. Methods: On a 3-tesla MRI system, BOLD CVR and DSC images were collected in a group of 19 patients with steno-occlusive cerebrovascular disease. For each patient, we generated a CVR magnitude map by regressing the BOLD signal with the end-tidal partial pressure of CO2 (PETCO2, and a CVR TD map by extracting the time of maximum cross-correlation between the BOLD signal and PETCO2. In addition, a blood arrival time map was generated by fitting the DSC signal with a gamma variate function. ROI masks corresponding to varying degrees of reactivity were constructed. Within these masks, the mean CVR magnitude, CVR TD and DSC blood arrival time were extracted and averaged over the 19 patients. CVR magnitude and CVR TD were then plotted against DSC blood arrival time. Results: The results show that CVR magnitude is highly correlated to DSC blood arrival time. As expected, the most compromised tissues with the longest blood arrival time have the lowest (most negative CVR magnitude. However, CVR TD shows a noncontinuous relationship with DSC blood arrival time. CVR TD is well correlated to DSC blood arrival time

  10. Canagliflozin Lowers Postprandial Glucose and Insulin by Delaying Intestinal Glucose Absorption in Addition to Increasing Urinary Glucose Excretion

    Polidori, David; Sha, Sue; Mudaliar, Sunder; Ciaraldi, Theodore P.; Ghosh, Atalanta; Vaccaro, Nicole; Farrell, Kristin; Rothenberg, Paul; Henry, Robert R.


    OBJECTIVE Canagliflozin, a sodium glucose cotransporter (SGLT) 2 inhibitor, is also a low-potency SGLT1 inhibitor. This study tested the hypothesis that intestinal canagliflozin levels postdose are sufficiently high to transiently inhibit intestinal SGLT1, thereby delaying intestinal glucose absorption. RESEARCH DESIGN AND METHODS This two-period, crossover study evaluated effects of canagliflozin on intestinal glucose absorption in 20 healthy subjects using a dual-tracer method. Placebo or c...

  11. The Structure of the Broad Line Region in AGN: I. Reconstructed Velocity-Delay Maps

    Grier, C J; Horne, Keith; Bentz, M C; Pogge, R W; Denney, K D; De Rosa, G; Martini, Paul; Kochanek, C S; Zu, Y; Shappee, B; Siverd, R; Beatty, T G; Sergeev, S G; Kaspi, S; Salvo, C Araya; Bird, J C; Bord, D J; Borman, G A; Che, X; Chen, C; Cohen, S A; Dietrich, M; Doroshenko, V T; Efimov, Yu S; Free, N; Ginsburg, I; Henderson, C B; King, A L; Mogren, K; Molina, M; Mosquera, A M; Nazarov, S V; Okhmat, D N; Pejcha, O; Rafter, S; Shields, J C; Skowron, J; Szczygiel, D M; Valluri, M; van Saders, J L


    We present velocity-resolved reverberation results for five active galactic nuclei. We recovered velocity-delay maps using the maximum-entropy method for four objects: Mrk 335, Mrk 1501, 3C120, and PG2130+099. For the fifth, Mrk 6, we were only able to measure mean time delays in different velocity bins of the H\\beta\\ emission line, but see tentative evidence of combined virial motion and infalling gas. The four velocity-delay maps show unique dynamical signatures for each object. For 3C120, the Balmer lines show kinematic signatures consistent with both an inclined disk and infalling gas, but the HeII 4686 emission line is suggestive only of inflow. The Balmer lines in Mrk 335, Mrk 1501, and PG 2130+099 show signs of infalling gas, but the HeII emission in Mrk 335 is consistent with an inclined disk. The maps for 3C120 and Mrk 335 are two of the most clearly defined velocity-delay maps to date. These maps constitute a large increase in the number of objects for which we have resolved velocity-delay maps and ...

  12. Analysis of a grid ionospheric vertical delay and its bounding errors over West African sub-Saharan region

    Abe, O. E.; Otero Villamide, X.; Paparini, C.; Radicella, S. M.; Nava, B.


    Investigating the effects of the Equatorial Ionization Anomaly (EIA) ionosphere and space weather on Global Navigation Satellite Systems (GNSS) is very crucial, and a key to successful implementation of a GNSS augmentation system (SBAS) over the equatorial and low-latitude regions. A possible ionospheric vertical delay (GIVD, Grid Ionospheric Vertical Delay) broadcast at a Ionospheric Grid Point (IGP) and its confidence bounds errors (GIVE, Grid Ionospheric Vertical Error) are analyzed and compared with the ionospheric vertical delay estimated at a nearby user location over the West African Sub-Saharan region. Since African sub-Saharan ionosphere falls within the EIA region, which is always characterized by a disturbance in form of irregularities after sunset, and the disturbance is even more during the geomagnetically quiet conditions unlike middle latitudes, the need to have a reliable ionospheric threat model to cater for the nighttime ionospheric plasma irregularities for the future SBAS user is essential. The study was done during the most quiet and disturbed geomagnetic conditions on October 2013. A specific low latitude EGNOS-like algorithm, based on single thin layer model, was engaged to simulate SBAS message in the study. Our preliminary results indicate that, the estimated GIVE detects and protects a potential SBAS user against sampled ionospheric plasma irregularities over the region with a steep increment in GIVE to non-monitored after local sunset to post midnight. This corresponds to the onset of the usual ionospheric plasma irregularities in the region. The results further confirm that the effects of the geomagnetic storms on the ionosphere are not consistent in affecting GNSS applications over the region. Finally, this paper suggests further work to be investigated in order to improve the threat integrity model activity, and thereby enhance the availability of the future SBAS over African sub-Saharan region.

  13. Canagliflozin Lowers Postprandial Glucose and Insulin by Delaying Intestinal Glucose Absorption in Addition to Increasing Urinary Glucose Excretion

    Polidori, David; Sha, Sue; Mudaliar, Sunder; Ciaraldi, Theodore P.; Ghosh, Atalanta; Vaccaro, Nicole; Farrell, Kristin; Rothenberg, Paul; Henry, Robert R.


    OBJECTIVE Canagliflozin, a sodium glucose cotransporter (SGLT) 2 inhibitor, is also a low-potency SGLT1 inhibitor. This study tested the hypothesis that intestinal canagliflozin levels postdose are sufficiently high to transiently inhibit intestinal SGLT1, thereby delaying intestinal glucose absorption. RESEARCH DESIGN AND METHODS This two-period, crossover study evaluated effects of canagliflozin on intestinal glucose absorption in 20 healthy subjects using a dual-tracer method. Placebo or canagliflozin 300 mg was given 20 min before a 600-kcal mixed-meal tolerance test. Plasma glucose, 3H-glucose, 14C-glucose, and insulin were measured frequently for 6 h to calculate rates of appearance of oral glucose (RaO) in plasma, endogenous glucose production, and glucose disposal. RESULTS Compared with placebo, canagliflozin treatment reduced postprandial plasma glucose and insulin excursions (incremental 0- to 2-h area under the curve [AUC0–2h] reductions of 35% and 43%, respectively; P < 0.001 for both), increased 0- to 6-h urinary glucose excretion (UGE0–6h, 18.2 ± 5.6 vs. <0.2 g; P < 0.001), and delayed RaO. Canagliflozin reduced AUC RaO by 31% over 0 to 1 h (geometric means, 264 vs. 381 mg/kg; P < 0.001) and by 20% over 0 to 2 h (576 vs. 723 mg/kg; P = 0.002). Over 2 to 6 h, canagliflozin increased RaO such that total AUC RaO over 0 to 6 h was <6% lower versus placebo (960 vs. 1,018 mg/kg; P = 0.003). A modest (∼10%) reduction in acetaminophen absorption was observed over the first 2 h, but this difference was not sufficient to explain the reduction in RaO. Total glucose disposal over 0 to 6 h was similar across groups. CONCLUSIONS Canagliflozin reduces postprandial plasma glucose and insulin by increasing UGE (via renal SGLT2 inhibition) and delaying RaO, likely due to intestinal SGLT1 inhibition. PMID:23412078

  14. Combining Meteosat-10 satellite image data with GPS tropospheric path delays to estimate regional integrated water vapor (IWV) distribution

    Leontiev, Anton; Reuveni, Yuval


    Using GPS satellites signals, we can study different processes and coupling mechanisms that can help us understand the physical conditions in the lower atmosphere, which might lead or act as proxies for severe weather events such as extreme storms and flooding. GPS signals received by ground stations are multi-purpose and can also provide estimates of tropospheric zenith delays, which can be converted into accurate integrated water vapor (IWV) observations using collocated pressure and temperature measurements on the ground. Here, we present for the first time the use of Israel's dense regional GPS network for extracting tropospheric zenith path delays combined with near-real-time Meteosat-10 water vapor (WV) and surface temperature pixel intensity values (7.3 and 10.8 µm channels, respectively) in order to assess whether it is possible to obtain absolute IWV (kg m-2) distribution. The results show good agreement between the absolute values obtained from our triangulation strategy based solely on GPS zenith total delays (ZTD) and Meteosat-10 surface temperature data compared with available radiosonde IWV absolute values. The presented strategy can provide high temporal and special IWV resolution, which is needed as part of the accurate and comprehensive observation data integrated in modern data assimilation systems and is required for increasing the accuracy of regional numerical weather prediction systems forecast.

  15. Immediate and delayed micro-tensile bond strength of different luting resin cements to different regional dentin.

    Ali, Abdelraheem Mohamed; Hamouda, Ibrahim Mohamed; Ghazy, Mohamed Hamed; Abo-Madina, Manal Mohamed


    We sought to evaluate immediate and delayed micro-tensile bond strength of Panavia F2.0 and Multilink Sprint resin cement to superficial, deep and cervical dentin. Thirty-six freshly extracted non-carious human molars were sectioned in the mesiodistal direction to expose three different dentin regions including superficial dentin (1 mm below the dentine-enamel junction), deep dentin (1 mm above the highest pulp horn) and cervical dentin (0.5 mm above the cemento-enamel junction and 0.5 mm below the dentine-enamel junction). Resin cements were applied on dentin surfaces and composite blocks were luted under constant seating pressure. Each group was divided into three subgroups according to time intervals. Specimens were sectioned to obtain sticks of 1 mm(2) in diameter and subjected to microtensile bond strength testing at a cross head speed of 1 mm/min. Both resin cements showed higher micro-tensile bond strength to superficial dentin than that to deep or cervical dentin (P Micro-tensile bond strengths of Panavia F2.0 were higher than those of Multilink Sprint at different dentin regions (P micro-tensile bond strengths were higher than those of delayed micro-tensile bond strengths for both resin cements (P micro-tensile bond strengths to different dentin regions.

  16. Immediate and delayed micro-tensile bond strength of different luting resin cements to different regional dentin

    Ali, Abdelraheem Mohamed; Hamouda, Ibrahim Mohamed; Ghazy, Mohamed Hamed; Abo-Madina, Manal Mohamed


    We sought to evaluate immediate and delayed micro-tensile bond strength of Panavia F2.0 and Multilink Sprint resin cement to superficial, deep and cervical dentin. Thirty-six freshly extracted non-carious human molars were sectioned in the mesiodistal direction to expose three different dentin regions including superficial dentin (1 mm below the dentine-enamel junction), deep dentin (1 mm above the highest pulp horn) and cervical dentin (0.5 mm above the cemento-enamel junction and 0.5 mm bel...

  17. Proteasome alteration and delayed neuronal death in hippocampal CA1 and dentate gyrus regions following transient cerebral ischemia

    Pengfei Ge; Tianfei Luo; Jizhou Zhang; Haifeng Wang; Wenchen Li; Yongxin Luan; Feng Ling; Yi'nan Luo


    BACKGROUND:Proteasome dysfunction has been reported to induce abnormal protein aggregation and cell death.OBJECTIVE:To investigate the effect of proteasome changes on delayed neuronal death in CA1 and dentate gyrus (DG) regions of the rat hippocampus following transient cerebral ischemia.DESIGN,TIME AND SETTING:A randomized,controlled animal experiment.The study was performed at the Department of Biochemistry and Molecular Biology,Norman Bethune Medical College of Jilin University,from September 2006 to May 2008.MATERIALS:Rabbit anti-19S S10B polyclonal antibody was purchased from Bioreagents,USA;propidium iodide and fluorescently-labeled goat anti-rabbit IgG were purchased from Jackson Immunoresearch,USA;hematoxylin and eosin staining solution was purchased from Sigma,USA;LSM 510 confocal microscope was purchased from Zeiss,Germany.METHODS:A total of 40 healthy Wistar rats,male,4 months old,were randomly divided into sham surgery group (n=8) and model group (n=32).Ischemic models were established in the model group by transient clamping of the bilateral carotid arteries and decreased blood pressure.After 20 minutes of global ischemia,the clamp was removed to allow blood flow for 30 minutes,4,24,and 72 hours,respectively,with 8 rats at each time point.The bilateral carotid arteries were not ligated in the sham surgery group.MAIN OUTCOME MEASURES:Neuronal death in the CA1 and DG regions was observed by hematoxylin-eosin staining.Proteasome expression in CA1 and DG region neurons was detected by immunohistochemistry.RESULTS:Hematoxylin-eosin staining showed neuronal death in the CA1 region alone at 72 hours of reperfusion following ischemia.In comparison to the sham surgery group,a significant decrease in proteasome expression was observed,by immunohistochemistry,in the CA1 and DG regions in the model group,following 30 minutes,4,24,and 72 hours of reperfusion (P<0.01).After 72 hours of reperfusion following ischemia,proteasome expression had almost completely

  18. Frequency, delay and velocity analysis for intrinsic channel region of carbon nanotube field effect transistors

    P. Geetha


    Full Text Available Gate wrap around field effect transistor is preferred for its good channel control. To study the high frequency behaviour of the device, parameters like cut-off frequency, transit or delay time, velocity are calculated and plotted. Double-walled and array of channels are considered in this work for enhanced output and impedance matching of the device with the measuring equipment terminal respectively. The perfomance of double-walledcarbon nanotube is compared with single-walled carbon nanotube and found that the device with double-wall shows appreciable improvement in its characteristics. Analysis of these parameters are done with various values of source/drain length, gate length, tube diameters and channel densities. The maximum cut-off frequency is found to be 72.3 THz with corresponding velocity as 5x106 m/s for channel density as 3 and gate length as 11nm. The number of channel is varied from 3 to 21 and found that the perfromance of the device containing double-walled carbon nano tube is better for channel number lesser than or equal to 12. The proposed modelling can be used for designing devices to handle high speed applications of future generation.

  19. Transferability of regional permafrost disturbance susceptibility modelling using generalized linear and generalized additive models

    Rudy, Ashley C. A.; Lamoureux, Scott F.; Treitz, Paul; van Ewijk, Karin Y.


    To effectively assess and mitigate risk of permafrost disturbance, disturbance-prone areas can be predicted through the application of susceptibility models. In this study we developed regional susceptibility models for permafrost disturbances using a field disturbance inventory to test the transferability of the model to a broader region in the Canadian High Arctic. Resulting maps of susceptibility were then used to explore the effect of terrain variables on the occurrence of disturbances within this region. To account for a large range of landscape characteristics, the model was calibrated using two locations: Sabine Peninsula, Melville Island, NU, and Fosheim Peninsula, Ellesmere Island, NU. Spatial patterns of disturbance were predicted with a generalized linear model (GLM) and generalized additive model (GAM), each calibrated using disturbed and randomized undisturbed locations from both locations and GIS-derived terrain predictor variables including slope, potential incoming solar radiation, wetness index, topographic position index, elevation, and distance to water. Each model was validated for the Sabine and Fosheim Peninsulas using independent data sets while the transferability of the model to an independent site was assessed at Cape Bounty, Melville Island, NU. The regional GLM and GAM validated well for both calibration sites (Sabine and Fosheim) with the area under the receiver operating curves (AUROC) > 0.79. Both models were applied directly to Cape Bounty without calibration and validated equally with AUROC's of 0.76; however, each model predicted disturbed and undisturbed samples differently. Additionally, the sensitivity of the transferred model was assessed using data sets with different sample sizes. Results indicated that models based on larger sample sizes transferred more consistently and captured the variability within the terrain attributes in the respective study areas. Terrain attributes associated with the initiation of disturbances were

  20. Risk analysis of the delayed ettringite formation in pile caps foundation in the metropolitan region of Recife - PE - Brasil

    I. F. Torres

    Full Text Available ABSTRACT Currently, there is an awareness that is critical to assess the durability characteristics of concrete with as much attention as the mechanical properties. The durability of concrete structures can often be affected by chemical attacks, jeopardizing its performance and security. When concrete is subjected to high temperature at early ages, many physical and chemical changes in hardened concrete may occur. It iswidely accepted that concrete subjected to these conditions of temperature and exposed to moisture is prone to cracking due to Delayed Ettringite Formation (DEF. This work aims at providing a DEF risk analysis on foundation pile caps at the Metropolitan Region of Recife - PE. Temperature rise measurement was performed in situ at 5 different caps through datalogger and thermocouples equipments. Furthermore, the Duggan test was performed in order to assess the level of expansion of 3 cements studied: X (CP II E 40, Y (CP II F 32 and Z (CP V ARI RS. Simultaneously, the chemical compositions of these cements and their respective clinkers were quantified by analysis of X-ray fluorescence (XRF. The cement X (CP II E 40 showed the chemical characteristics favoring with more intensity DEF and, as a result, higher level of expansion in the test Duggan. It is noteworthy that incorporation of metakaolin (8% and 16% and silica fume (5% and 10% showed mitigating potential of expansions. It is important to point out that all factors related to thermal properties and chemical composition of the concrete used in the region converge to a condition of ideal susceptibility for triggering DEF. Therefore, it is essential at least minimum and basic requirements in the design specification in order to avoid high temperatures in the massive concrete elements, preventing them from delayed ettringite formation.

  1. Sixteen additional enhancers associated with the chicken Sox2 locus outside the central 50-kb region.

    Okamoto, Ryuji; Uchikawa, Masanori; Kondoh, Hisato


    The transcription factor Sox2 plays a central role in the regulation of neuro-sensory development, and many other developmental processes. To gain an in depth understanding of the Sox2 gene regulation, we previously investigated the Sox2-proximal 50-kb region of the chicken genome to determine enhancers based on functional assays using chicken embryo electroporation. We identified 11 enhancers with specificity for neuro-sensory tissues. In this study, we extended the analysis of Sox2 locus-associated enhancers to a 200-kb region and identified 16 additional enhancers with functions in neuro-sensory development. These enhancers roughly correspond to a fraction of the sequence blocks that are highly conserved between chicken and mammalian genomes. The neural enhancers were activated in sequence, thereby creating a complex pattern of functional overlaps in the developing central nervous system (CNS). The variations in the specificities of the sensory enhancers also reflected the intermediate steps of sensory tissue development. This study provides an example where a single transcription factor gene has numerous regulatory elements that allow it to fulfill many functional roles in different biological contexts.

  2. The combination of trastuzumab and pertuzumab administered at approved doses may delay development of trastuzumab resistance by additively enhancing antibody-dependent cell-mediated cytotoxicity.

    Tóth, Gábor; Szöőr, Árpád; Simon, László; Yarden, Yosef; Szöllősi, János; Vereb, György


    Although the recently concluded CLEOPATRA trial showed clinical benefits of combining trastuzumab and pertuzumab for treating HER2-positive metastatic breast cancer, trastuzumab monotherapy is still the mainstay in adjuvant settings. Since trastuzumab resistance occurs in over half of these cancers, we examined the mechanisms by which treatment of intrinsically trastuzumab-resistant and -sensitive tumors can benefit from the combination of these antibodies. F(ab')2 of both trastuzumab and pertuzumab were generated and validated in order to separately analyze antibody-dependent cell-mediated cytotoxicity (ADCC)-based and direct biological effects of the antibodies. Compared to monotherapy, combination of the two antibodies at clinically permitted doses enhanced the recruitment of natural killer cells responsible for ADCC, and significantly delayed the outgrowth of xenografts from intrinsically trastuzumab-resistant JIMT-1 cells. Antibody dose-response curves of in vitro ADCC showed that antibody-mediated killing can be saturated, and the two antibodies exert an additive effect at sub-saturation doses. Thus, the additive effect in vivo indicates that therapeutic tissue levels likely do not saturate ADCC. Additionally, isobole studies with the in vitro trastuzumab-sensitive BT-474 cells showed that the direct biological effect of combined treatment is additive, and surpasses the maximum effect of either monotherapy. Our results suggest the combined therapy is expected to give results that are superior to monotherapy, whatever the type of HER2-positive tumor may be. The combination of both antibodies at maximum clinically approved doses should thus be administered to patients to recruit maximum ADCC and cause maximum direct biological growth inhibition.

  3. Additional effects of taurine on the benefits of BCAA intake for the delayed-onset muscle soreness and muscle damage induced by high-intensity eccentric exercise.

    Ra, Song-Gyu; Miyazaki, Teruo; Ishikura, Keisuke; Nagayama, Hisashi; Suzuki, Takafumi; Maeda, Seiji; Ito, Masaharu; Matsuzaki, Yasushi; Ohmori, Hajime


    Taurine (TAU) has a lot of the biological, physiological, and pharmocological functions including anti-inflammatory and anti-oxidative stress. Although previous studies have appreciated the effectiveness of branched-chain amino acids (BCAA) on the delayed-onset muscle soreness (DOMS), consistent finding has not still convinced. The aim of this study was to examine the additional effect of TAU with BCAA on the DOMS and muscle damages after eccentric exercise. Thirty-six untrained male volunteers were equally divided into four groups, and ingested a combination with 2.0 g TAU (or placebo) and 3.2 g BCAA (or placebo), thrice a day, 2 weeks prior to and 4 days after elbow flexion eccentric exercise. Following the period after eccentric exercise, the physiological and blood biochemical markers for DOMS and muscle damage showed improvement in the combination of TAU and BCAA supplementation rather than in the single or placebo supplementations. In conclusion, additional supplement of TAU with BCAA would be a useful way to attenuate DOMS and muscle damages induced by high-intensity exercise.

  4. Detection of postischemic regional left ventricular delayed outward wall motion or diastolic stunning after exercise-induced ischemia in patients with stable effort angina by using color kinesis.

    Ishii, Katsuhisa; Miwa, Kunihisa; Sakurai, Takahiro; Kataoka, Kazuaki; Imai, Makoto; Kintaka, Aya; Aoyama, Takeshi; Kawanami, Masaki


    To determine whether postischemic diastolic stunning could be detected using color kinesis, we evaluated regional left ventricular (LV) diastolic wall motion in 36 patients with stable effort angina and a coronary stenosis (> or = 70% of luminal diameter), and in 30 control subjects. Regional LV filling fraction in the short-axis view during the first 30% of the LV filling time (color kinesis diastolic index) was determined before, 20 minutes, 1 hour, and 24 hours after the treadmill exercise test. In 33 of the 36 patients (92%), new regional LV delayed outward motion during early diastole (color kinesis diastolic index < or = 40%) was detected at 20 minutes after exercise. The regional LV delayed diastolic wall motion showed significant improvement but persisted 1 hour afterward in 20 of 36 patients (56%), and disappeared 24 hours after exercise. Detection of regional stunned myocardium with impaired diastolic function may be a useful tool for the diagnosis of coronary artery disease.

  5. Targeted silencing of DNA-specific B cells combined with partial plasma cell depletion displays additive effects on delaying disease onset in lupus-prone mice.

    Nikolova-Ganeva, K A; Gesheva, V V; Todorov, T A; Voll, R E; Vassilev, T L


    Targeting autoreactive B lymphocytes at any stage of their differentiation could yield viable therapeutic strategies for treating autoimmunity. All currently used drugs, including the most recently introduced biological agents, lack target specificity. Selective silencing of double-stranded DNA-specific B cells in animals with spontaneous lupus has been achieved previously by the administration of a chimeric antibody molecule that cross-links their DNA-reactive B cell immunoglobulin receptors with inhibitory FcγIIb (CD32) receptors. However, long-lived plasmacytes are resistant to this chimeric antibody as well as to all conventional treatments. Bortezomib (a proteasome inhibitor) depletes most plasma cells and has been shown recently to suppress disease activity in lupus mice. We hypothesized that the co-administration of non-toxic doses of bortezomib, that partially purge long-lived plasma cells, together with an agent that selectively silences DNA-specific B cells, should have additive effects in an autoantibody-mediated disease. Indeed, our data show that the simultaneous treatment of lupus-prone MRL/lpr mice with suboptimal doses of bortezomib plus the chimeric antibody resulted in the prevention or the delayed appearance of the disease manifestations as well as in a prolonged survival. The effect of the combination therapy was significantly stronger than that of the respective monotherapies and was comparable to that observed after cyclophosphamide administration.

  6. Saethre-Chotzen syndrome with severe developmental delay associated with deletion of chromosomic region 7p15 --> pter.

    Touliatou, V; Mavrou, A; Kolialexi, A; Kanavakis, E; Kitsiou-Tzeli, S


    Saethre-Chotzen syndrome represents one of the most common types of craniosynostosis inherited as an autosomal dominant disorder while sporadic cases have also been reported. It is characterized by high penetrance and variable expressivity, leading to difficulties in clinical diagnosis. Some patients, who exhibit most of the diagnostic criteria of Saethre-Chotzen syndrome, have structural abnormalities of chromosome 7. The case of a 4 year old boy with notable dysmorphic features compatible with Saethre-Chotzen syndrome and severe developmental delay is described. Conventional and molecular cytogenetic analysis of peripheral blood samples from the patient and his parents revealed partial monosomy of chromosomal region 7p15 --> pter de novo. The TWIST gene, located on chromosome 7p21.1, is thought to be a negative transcriptional regulator involved in osteoblast differentiation and maturation and it is thought that haploinsufficiency of the gene can cause the disorder. The diagnosis of Saethre-Chotzen syndrome and the identification of the chromosomal abnormality in the patient facilitated genetic counseling of the family.

  7. Serotonin Transporter Promoter Region (5-HTTLPR) Polymorphism Is Not Associated With Paroxetine-Induced Ejaculation Delay in Dutch Men With Lifelong Premature Ejaculation

    Janssen, Paddy K C; Zwinderman, Aeilko H; Olivier, Berend; Waldinger, Marcel D


    PURPOSE: To investigate the association between the 5-HT-transporter-gene-linked promoter region (5-HTTLPR) polymorphism and 20-mg paroxetine-induced ejaculation delay in men with lifelong premature ejaculation (LPE). MATERIALS AND METHODS: This was a prospective study of 10 weeks of paroxetine trea

  8. Dynamics of cerebral tissue injury and perfusion after temporary hypoxia-ischemia in the rat - Evidence for region-specific sensitivity and delayed damage

    Dijkhuizen, RM; Knollema, S; van der Worp, H. Bart; Ter Horst, GJ; De Wildt, DJ; van der Sprenkel, JWB; Tulleken, KAF; Nicolay, K


    Background and Purpose-Selective regional sensitivity and delayed damage in cerebral ischemia provide opportunities for directed and late therapy for stroke. Our aim was to characterize the spatial and temporal profile of ischemia-induced changes in cerebral perfusion and tissue status, with the use

  9. The structure of the broad-line region in active galactic nuclei. I. Reconstructed velocity-delay maps

    Grier, C.J.; Peterson, B.M.; Pogge, R.W.;


    We present velocity-resolved reverberation results for five active galactic nuclei. We recovered velocity-delay maps using the maximum entropy method for four objects: Mrk 335, Mrk 1501, 3C 120, and PG 2130+099. For the fifth, Mrk 6, we were only able to measure mean time delays in different...

  10. Attosecond time delay in the photoionization of Mn in the $3p \\rightarrow 3d$ giant resonance region

    Dolmatov, V K; Deshmukh, P C; Manson, S T


    The dramatic effect of the $3p \\rightarrow 3d$ giant autoionization resonance on time delay of photoemission from the $3d$ and $4s$ valence subshells of the Mn atom is unraveled. Strong sensitivity of the time delay of the $4s$ photoemission to the final-state term of the ion-remainder [${\\rm Mn^{+}}(4s^{1},$$^{5}S)$ vs. ${\\rm Mn^{+}}(4s^{1},$$^{7}S)$] is discovered. The features of time delay uncovered in Mn photoionization are expected to be general properties of transition-metal atoms and ions. The "spin-polarized" random phase approximation with exchange was employed in the study.

  11. Delayed Treatment with Sodium Hydrosulfide Improves Regional Blood Flow and Alleviates Cecal Ligation and Puncture (CLP)-Induced Septic Shock.

    Ahmad, Akbar; Druzhyna, Nadiya; Szabo, Csaba


    Cecal ligation and puncture (CLP)-induced sepsis is a serious medical condition, caused by a severe systemic infection resulting in a systemic inflammatory response. Recent studies have suggested the therapeutic potential of donors of hydrogen sulfide (H2S), a novel endogenous gasotransmitter and biological mediator in various diseases. The aim of the present study was to assess the effect of H2S supplementation in sepsis, with special reference to its effect on the modulation of regional blood flow. We infused sodium hydrosulfide (NaHS), a compound that produces H2S in aqueous solution (1, 3, or 10 mg/kg/h, for 1 h at each dose level) in control rats or rats 24 h after CLP, and measured blood flow using fluorescent microspheres. In normal control animals, NaHS induced a characteristic redistribution of blood flow, and reduced cardiac, hepatic, and renal blood flow in a dose-dependent fashion. In contrast, in rats subjected to CLP, cardiac, hepatic, and renal blood flow was significantly reduced; infusion of NaHS (1 mg/kg/h and 3 mg/kg/h) significantly increased organ blood flow. In other words, the effect of H2S on regional blood flow is dependent on the status of the animals (i.e., a decrease in blood flow in normal controls, but an increase in blood flow in CLP). We have also evaluated the effect of delayed treatment with NaHS on organ dysfunction and the inflammatory response by treating the animals with NaHS (3 mg/kg) intraperitoneally (i.p.) at 24 h after the start of the CLP procedure; plasma levels of various cytokines and tissue indicators of inflammatory cell infiltration and oxidative stress were measured 6 h later. After 24 h of CLP, glomerular function was significantly impaired, as evidenced by markedly increased (over 4-fold over baseline) blood urea nitrogen and creatinine levels; this increase was also significantly reduced by treatment with NaHS. NaHS also attenuated the CLP-induced increases in malondialdehyde levels (an index of

  12. The perspective of private practitioners regarding tuberculosis case detection and treatment delay in Amhara Region, Ethiopia: a cross-sectional study

    Yimer Solomon A


    Full Text Available Abstract Background Engaging all health care providers in tuberculosis (TB control has been incorporated as an essential component of World Health Organization's Stop TB Strategy and the Stop TB Partnership's global plan 2006-2015. Ethiopia has a growing private health sector. The objective of the present study was to investigate the role of private practitioners (PPs in TB case detection and assess their perspectives on TB treatment delay in Amhara Region, Ethiopia. Results A cross-sectional study among 112 PPs selected from private health facilities (PHF in the region was conducted. The study was carried out between May and August 2008 and data was collected using a semi-structured questionnaire. Group differences were analyzed using one-way Anova test and a p-value of In this study, PPs saw a median of 12 TB suspects and 1.5 patients a week. The mean number of TB suspects and patients seen varied significantly among the different professions with p Conclusion PPs manage a substantial number of TB suspects and patients in Amhara Region, Ethiopia. The GHF delay observed among TB patients referred by PPs to GHF is unnecessary. Expanding PPM-DOTS in the region and improving the quality of TB care at both government and private health facilities reduces treatment delay and increases TB case detection.


    Grier, C. J.; Peterson, B. M.; Pogge, R. W.; De Rosa, G.; Martini, Paul; Kochanek, C. S.; Zu, Y.; Shappee, B.; Beatty, T. G.; Salvo, C. Araya; Bird, J. C. [Department of Astronomy, The Ohio State University, 140 W 18th Ave, Columbus, OH 43210 (United States); Horne, Keith [SUPA Physics and Astronomy, University of St. Andrews, Fife, KY16 9SS Scotland (United Kingdom); Bentz, M. C. [Department of Physics and Astronomy, Georgia State University, Astronomy Offices, One Park Place South SE, Suite 700, Atlanta, GA 30303 (United States); Denney, K. D. [Marie Curie Fellow at the Dark Cosmology Centre, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, DK-2100 Copenhagen (Denmark); Siverd, R. [Department of Physics and Astronomy, Vanderbilt University, 5301 Stevenson Center, Nashville, TN 37235 (United States); Sergeev, S. G.; Borman, G. A. [Crimean Astrophysical Observatory, P/O Nauchny Crimea 98409 (Ukraine); Kaspi, S. [School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978 (Israel); Bord, D. J. [Department of Natural Sciences, The University of Michigan - Dearborn, 4901 Evergreen Rd, Dearborn, MI 48128 (United States); Che, X. [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 41809 (United States); and others


    We present velocity-resolved reverberation results for five active galactic nuclei. We recovered velocity-delay maps using the maximum entropy method for four objects: Mrk 335, Mrk 1501, 3C 120, and PG 2130+099. For the fifth, Mrk 6, we were only able to measure mean time delays in different velocity bins of the H{beta} emission line. The four velocity-delay maps show unique dynamical signatures for each object. For 3C 120, the Balmer lines show kinematic signatures consistent with both an inclined disk and infalling gas, but the He II {lambda}4686 emission line is suggestive only of inflow. The Balmer lines in Mrk 335, Mrk 1501, and PG 2130+099 show signs of infalling gas, but the He II emission in Mrk 335 is consistent with an inclined disk. We also see tentative evidence of combined virial motion and infalling gas from the velocity-binned analysis of Mrk 6. The maps for 3C 120 and Mrk 335 are two of the most clearly defined velocity-delay maps to date. These maps constitute a large increase in the number of objects for which we have resolved velocity-delay maps and provide evidence supporting the reliability of reverberation-based black hole mass measurements.

  14. β-delayed proton decay of the proton drip-line nucleus 142Ho in the rare-earth region

    XU; Shuwei(徐树威); LI; Zhankui(李占奎); XIE; Yuanxiang(谢元祥); XU; Furong(徐甫荣); WANG; Xudong(王旭东); GUO; Bin(郭斌); LENG; Changgeng(冷长庚); YU; Yong(于涌); WANG; Chunfang(王春芳); XING; Jianping(邢建萍); CHEN; Hongyan(陈红艳)


    New β-delayed proton precursor 142Ho was produced via heavy ion induced reaction 106Cd(40Ca, p3n), and identified for the first time by using a He-jet fast tape transport system in combination with "p-γ" coincidence measurements. The β-delayed proton decay of 142Ho was observed and its half life was determined to be (0.4±0.1) s. By fitting the experimental relative branching ratios to final states in the proton daughter nucleus 141Tb and the energy spectrum of β-delayed protons with a statistical model calculation, the ground-state spin of 142Ho was assigned as 5, 6 or 7. Nuclear energy-potential-surface (EPS) calculations were performed using the Woods-Saxon Strutinsky method. The calculated results favored the assignments of 7- to 142Ho. AS the by-products, some γ-transitions in the proton daughter nuclei following the β-delayed proton decays of precursors 139Gd, 140Tb, 142Tb, and 143Dy were reported here for the first time.

  15. Combining METEOSAT-10 satellite image data with GPS tropospheric path delays to estimate regional Integrated Water Vapor (IWV) distribution


    Using GPS satellites signals, we can study different processes and coupling mechanisms that can help us understand the physical conditions in the upper atmosphere, which might lead or act as proxies for severe weather events such as extreme storms and flooding. GPS signals received by ground stations are multi-purpose and can also provide estimates of tropospheric zenith delays, which can be converted into mm-accuracy Precipitable Water Vapor (PWV) using collocated pressure and temperature me...

  16. Retrieval of Wet-Tropospheric Path Delay over Coastal and Inland Water Regions using Wide-band Millimeter-Wave Radiometry

    Bosch-Lluis, Xavier; Gilliam, Kyle L.; Reising, Steven C.; Tanner, Alan B.; Brown, Shannon T.; Kangaslahti, Pekka


    Currently, wet-tropospheric path delay measurements over inland water and coastal areas are extremely sparse. They are generally limited to twice-per-day radiosonde launches and a small number of ground-based GPS or radiometer path delay measurements, as well as radar measurements of phase delay to a small number of fixed targets on the ground. Knowledge of the wet-tropospheric path delay is necessary for next-generation high-resolution altimeters, such as the Surface Water and Ocean Topography (SWOT) mission, in formulation and planned for launch in 2020. SWOT has two major science objectives. First, the oceanographic objective is to characterize ocean mesoscale and sub-mesoscale circulation with horizontal resolution of 10 km and order of 1 cm height precision. Second, the hydrological objective is to provide global height measurements of inland surface water bodies with area of greater than 250 square meters and flow rate of rivers with width greater than 100 m. Wet-tropospheric path delay retrieval over coastal and inland-water areas is needed to achieve both of these objectives with sufficient height accuracy. In addition, information on total precipitable water vapor under nearly all weather conditions is needed to improve initialization of numerical weather prediction models. Currently, 18-34 GHz microwave radiometers provide wet-path delay corrections for the Jason series of nadir-viewing altimeters. However, these retrievals are limited to open ocean, and land incursion is unacceptable within 40 km of coastlines. The addition of millimeter-wave radiometers (70-170 GHz) is needed to address this problem by providing smaller surface footprint dimensions proportional to wavelength. In this work, we present a prototype algorithm to demonstrate the potential to retrieve wet-tropospheric path delay from brightness temperatures measured by millimeter-wave radiometers using the Brightness Temperature Deflection Ratio (BTDR) method. The BTDR algorithm retrieves wet

  17. Regional dGEMRIC analysis in patients at risk of osteoarthritis provides additional information about activity related changes in cartilage structure

    Hawezi, Z K; Lammentausta, E; Svensson, J;


    BACKGROUND: Previously, a positive effect of exercise on cartilage structure was indicated with delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC). However, in that study only one full-thickness region of interest (ROI) in the medial femoral condyle was analyzed...

  18. An Analytical Delay Model

    MIN Yinghua; LI Zhongcheng


    Delay consideration has been a majorissue in design and test of high performance digital circuits. Theassumption of input signal change occurring only when all internal nodesare stable restricts the increase of clock frequency. It is no longertrue for wave pipelining circuits. However, previous logical delaymodels are based on the assumption. In addition, the stable time of arobust delay test generally depends on the longest sensitizable pathdelay. Thus, a new delay model is desirable. This paper explores thenecessity first. Then, Boolean process to analytically describe thelogical and timing behavior of a digital circuit is reviewed. Theconcept of sensitization is redefined precisely in this paper. Based onthe new concept of sensitization, an analytical delay model isintroduced. As a result, many untestable delay faults under thelogical delay model can be tested if the output waveforms can be sampledat more time points. The longest sensitizable path length is computedfor circuit design and delay test.

  19. New β-delayed proton decays in the rare-earth region near the proton drip line

    徐树威; 李占奎; 谢元祥; 于涌; 潘强岩; 王春芳; 邢建萍; 马瑞昌; 葛元秀; 张天梅


    The p-delayed proton precursors 125Nd, 128Pm, 129Sm, 137Gd and 139Dy near the proton drip line were produced by the irradiation of 92Mo, 96Ru and 106Cd with an 36Ar beam, and conclusively identified for the first time by using proton-gamma coincidence in combination with a He-jet tape transport system. Their half-lives were determined to be 0.60(15)s,1.0(3)s,0.55(10)s,2.2(2)s and 0.6 (2)s, respectively. The measured energy spectra of β-delayed protons and estimated proton branching ratios to the final states in "daughter" nuclei for the precursors 125Nd, 129Sm, 137Gd and 139Dy, as well as the previously reported ones for the precursors 135 Gd and 121 Ce, were fitted by a statistical model calculation. The ground-state spins and parities of 121Ce, 125Nd, 129Sm, 135Gd, 137Gd and 139Dy were then assigned as 5/2± ,5/2± ,1/2± (or 3/2+) ,5/2 + ,1/2± and 7/2, respectively. The consistency between the experimental spin-parity assignment and the predicted Nilsson diagrams indirectly indicates that the groun

  20. New β-delayed proton decays in the rare-earth region near the proton drip line


    The β-delayed proton precursors 125Nd, 128Pm, 129Sm, 137Gd and 139Dy near the proton drip line were produced by the irradiation of 92Mo, 96Ru and 106Cd with an 36Ar beam, and conclusively identified for the first time by using proton-gamma coincidence in combination with a He-jet tape transport system. Their half-lives were determined to be 0.60(15)s,1.0(3)s,0.55(10)s,2.2(2)s and 0.6(2)s, respectively. The measured energy spectra of β-delayed protons and estimated proton branching ratios to the final states in "daughter" nuclei for the precursors 125Nd, 129Sm, 137Gd and 139Dy, as well as the previously reported ones for the precursors 135Gd and 121Ce, were fitted by a statistical model calculation. The ground-state spins and parities of 121Ce, 125Nd, 129Sm, 135Gd, 137Gd and 139Dy were then assigned as 5/2±,5/2±,1/2±(or 3/2+),5/2+,7/2± and 7/2, respectively. The consistency between the experimental spin-parity assignment and the predicted Nilsson diagrams indirectly indicates that the ground states of 121Ce, 125Nd, 129Sm, 135Gd, 137Gd and 139Dy are highly deformed with β2~0.3.

  1. Serotonin Transporter Promoter Region (5-HTTLPR) Polymorphism Is Not Associated With Paroxetine-Induced Ejaculation Delay in Dutch Men With Lifelong Premature Ejaculation

    Janssen, Paddy K.C.; Zwinderman, Aeilko H.; Olivier, Berend


    Purpose To investigate the association between the 5-HT-transporter-gene-linked promoter region (5-HTTLPR) polymorphism and 20-mg paroxetine-induced ejaculation delay in men with lifelong premature ejaculation (LPE). Materials and Methods This was a prospective study of 10 weeks of paroxetine treatment in 54 men with LPE. Intravaginal ejaculation latency time (IELT) was measured by stopwatch. Controls consisted of 92 Caucasian men. All men with LPE were genotyped for the 5-HTTLPR polymorphism. Allele frequencies and genotypes of short (S) and long (L) variants of the polymorphism were compared between patients and controls. Associations between the LL, SL, and SS genotypes and fold increase of mean IELT were investigated. Results Of the 54 patients, 43 (79.6%) responded to 20-mg paroxetine treatment with an ejaculation delay, whereas 11 patients (20.4%) did not respond; 44%, 18%, and 18% of the patients showed a fold increase in mean IELT of 2-10, 10-20, and more than 20, respectively. Of the 54 men, 14 (25.9%) had the LL genotype, 29 (53.7%) had the SL genotype, and 11 (20.4%) had the SS genotype. In the 92 controls, the LL, SL, and SS genotypes were present in 27 (29.3%), 41 (44.6%), and 24 (26.1%), respectively. No statistically significant differences were found in 5-HTTLPR allelic variations or in 5-HTTLPR gene variations. In all men treated with 20 mg paroxetine, analysis of variance of the natural logarithm of fold increase in the IELT showed no statistically significant difference according to genotype (p=0.83). Conclusions The 5-HTTLPR polymorphism is not associated with daily 20-mg paroxetine treatment-induced ejaculation delay in men with LPE. PMID:24578810

  2. Delayed fission

    Hatsukawa, Yuichi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment


    Delayed fission is a nuclear decay process that couples {beta} decay and fission. In the delayed fission process, a parent nucleus undergoes {beta} decay and thereby populates excited states in the daughter. If these states are of energies comparable to or greater than the fission barrier of the daughter, then fission may compete with other decay modes of the excited states in the daughter. In this paper, mechanism and some experiments of the delayed fission will be discussed. (author)

  3. Apollo 16 regolith breccias and soils - Recorders of exotic component addition to the Descartes region of the moon

    Simon, S. B.; Papike, J. J.; Laul, J. C.; Hughes, S. S.; Schmitt, R. A.


    Using the subdivision of Apollo 16 regolith breccias into ancient (about 4 Gyr) and younger samples (McKay et al., 1986), with the present-day soils as a third sample, a petrologic and chemical determination of regolith evolution and exotic component addition at the A-16 site was performed. The modal petrologies and mineral and chemical compositions of the regolith breccias in the region are presented. It is shown that the early regolith was composed of fragments of plutonic rocks, impact melt rocks, and minerals and impact glasses. It is found that KREEP lithologies and impact melts formed early in lunar history. The mare components, mainly orange high-TiO2 glass and green low-TiO2 glass, were added to the site after formation of the ancient breccias and prior to the formation of young breccias. The major change in the regolith since the formation of the young breccias is an increase in maturity represented by the formation of fused soil particles with prolonged exposure to micrometeorite impacts.

  4. Demographic determinants of delayed divorce.

    Chan, L Y; Heaton, T B


    This study identifies factors that predict delayed divorce in the US. The findings show that factors which influence marital stability in general also correlate with delayed divorce in the same direction. Wife's age at marriage, age of the youngest child, wife's religion, region of residence, and metropolitan residence have substantial effects of delayed divorce, but the effects of race, parental divorce, premarital pregnancy, and socioeconomic status are small.

  5. Synchronization transitions on small-world neuronal networks: Effects of information transmission delay and rewiring probability

    Wang, Qingyun; Duan, Zhisheng; Perc, Matjaž; Chen, Guanrong


    Synchronization transitions are investigated in small-world neuronal networks that are locally modeled by the Rulkov map with additive spatiotemporal noise. In particular, we investigate the impact of different information transmission delays and rewiring probability. We show that short delays induce zigzag fronts of excitations, whereas intermediate delays can further detriment synchrony in the network due to a dynamic clustering anti-phase synchronization transition. Detailed investigations reveal, however, that for longer delay lengths the synchrony of excitations in the network can again be enhanced due to the emergence of in-phase synchronization. In addition, we show that an appropriate small-world topology can restore synchronized behavior provided information transmission delays are either short or long. On the other hand, within the intermediate delay region, which is characterized by anti-phase synchronization and clustering, differences in the network topology do not notably affect the synchrony of neuronal activity.

  6. Synchronizing time delay systems using variable delay in coupling

    Ambika, G., E-mail: [Indian Institute of Science Education and Research, Pune 411 021 (India); Amritkar, R.E., E-mail: [Physical Research Laboratory, Ahmedabad 380 009 (India)


    Highlights: > Delay and anticipation in coupling function varies with system dynamics. > Delay or anticipation of the synchronized state is independent of system delay. > Stability analysis developed is quite general. > We demonstrate enhanced security in communication. > Generalized synchronization possible over a wide range of parameter mismatch. - Abstract: We present a mechanism for synchronizing time delay systems using one way coupling with a variable delay in coupling that is reset at finite intervals. We present the analysis of the error dynamics that helps to isolate regions of stability of the synchronized state in the parameter space of interest for single and multiple delays. We supplement this by numerical simulations in a standard time delay system like Mackey Glass system. This method has the advantage that it can be adjusted to be delay or anticipatory in synchronization with a time which is independent of the system delay. We demonstrate the use of this method in communication using the bi channel scheme. We show that since the synchronizing channel carries information from transmitter only at intervals of reset time, it is not susceptible to an easy reconstruction.

  7. Best Linear Unbiased Prediction (BLUP) for regional yield trials: a comparison to additive main effects and multiplicative interaction (AMMI) analysis.

    Piepho, H P


    Multilocation trials are often used to analyse the adaptability of genotypes in different environments and to find for each environment the genotype that is best adapted; i.e. that is highest yielding in that environment. For this purpose, it is of interest to obtain a reliable estimate of the mean yield of a cultivar in a given environment. This article compares two different statistical estimation procedures for this task: the Additive Main Effects and Multiplicative Interaction (AMMI) analysis and Best Linear Unbiased Prediction (BLUP). A modification of a cross validation procedure commonly used with AMMI is suggested for trials that are laid out as a randomized complete block design. The use of these procedure is exemplified using five faba bean datasets from German registration trails. BLUP was found to outperform AMMI in four of five faba bean datasets.

  8. Dynamic Cournot Duopoly Game with Delay

    A. A. Elsadany


    Full Text Available The delay Cournot duopoly game is studied. Dynamical behaviors of the game are studied. Equilibrium points and their stability are studied. The results show that the delayed system has the same Nash equilibrium point and the delay can increase the local stability region.

  9. An examination of the origin and evolution of additional tandem repeats in the mitochondrial DNA control region of Japanese sika deer (Cervus Nippon).

    Ba, Hengxing; Wu, Lang; Liu, Zongyue; Li, Chunyi


    Tandem repeat units are only detected in the left domain of the mitochondrial DNA control region in sika deer. Previous studies showed that Japanese sika deer have more tandem repeat units than its cousins from the Asian continent and Taiwan, which often have only three repeat units. To determine the origin and evolution of these additional repeat units in Japanese sika deer, we obtained the sequence of repeat units from an expanded dataset of the control region from all sika deer lineages. The functional constraint is inferred to act on the first repeat unit because this repeat has the least sequence divergence in comparison to the other units. Based on slipped-strand mispairing mechanisms, the illegitimate elongation model could account for the addition or deletion of these additional repeat units in the Japanese sika deer population. We also report that these additional repeat units could be occurring in the internal positions of tandem repeat regions, possibly via coupling with a homogenization mechanism within and among these lineages. Moreover, the increased number of repeat units in the Japanese sika deer population could reflect a balance between mutation and selection, as well as genetic drift.

  10. Permissible Delay in Payments

    Yung-Fu Huang


    Full Text Available The main purpose of this paper wants to investigate the optimal retailer's lot-sizing policy with two warehouses under partially permissible delay in payments within the economic order quantity (EOQ framework. In this paper, we want to extend that fully permissible delay in payments to the supplier would offer the retailer partially permissible delay in payments. That is, the retailer must make a partial payment to the supplier when the order is received. Then the retailer must pay off the remaining balance at the end of the permissible delay period. In addition, we want to add the assumption that the retailer's storage space is limited. That is, the retailer will rent the warehouse to store these exceeding items when the order quantity is larger than retailer's storage space. Under these conditions, we model the retailer's inventory system as a cost minimization problem to determine the retailer's optimal cycle time and optimal order quantity. Three theorems are developed to efficiently determine the optimal replenishment policy for the retailer. Finally, numerical examples are given to illustrate these theorems and obtained a lot of managerial insights.

  11. Effects of Addition of Systemic Tramadol or Adjunct Tramadol to Lidocaine Used for Intravenous Regional Anesthesia in Patients Undergoing Hand Surgery

    Abdulkadir Yektaş; Funda Gümüş; Abdulhalim Karayel; Ayşin Alagöl


    Intravenous regional anesthesia (IVRA) is used in outpatient hand surgery as an easily applicable and cost-effective technique with clinical advantages. The present study aimed to investigate the effects of addition of systemic tramadol or adjunct tramadol to lidocaine for IVRA in patients undergoing hand surgery. American Society of Anesthesiologists (ASA) I-II patients (n = 60) who underwent hand surgery were included. For this purpose, only lidocaine (LDC), lidocaine+adjunct tramadol (LDC+...

  12. Systematics in delayed neutron yields

    Ohsawa, Takaaki [Kinki Univ., Higashi-Osaka, Osaka (Japan). Atomic Energy Research Inst.


    An attempt was made to reproduce the systematic trend observed in the delayed neutron yields for actinides on the basis of the five-Gaussian representation of the fission yield together with available data sets for delayed neutron emission probability. It was found that systematic decrease in DNY for heavier actinides is mainly due to decrease of fission yields of precursors in the lighter side of the light fragment region. (author)

  13. Simulation Analysis of Flight Delays in Pearl River Delta Region%珠三角地区航班延误的仿真分析

    朱承元; 王馨悦; 刁琳


    Pearl River Delta region(PRD) suffers the problem of high-density airports,airspace congestion and a high delay of flights.It is necessary to research on the airspace and airport in PRD.The key points of PRD′s airspace and airport modeling based on SIMMOD(Airport and Airspace Simulation Model) are introduced.The SIMMOD model is validated by Theil′s inequality coefficients,and then the present flights delays and air traffic flow distribution in PRD are analyzed by SIMMOD Simulation.The air-ground situation under the maximum flights is simulated,and the bottlenecks of limiting flight flow in PRD are identified by the statistical analysis of the flight delays.%珠三角地区机场密集、空域紧张,导致该地区交通拥挤,航班延误高,迫切需要对其空域和机场进行研究。论文描述了采用空域机场仿真模型SIMMOD对珠三角地区的空域机场进行建模的关键点。采用THEIL不等式系数法对该SIMMOD模型进行了验证。分析了当前珠三角地区的航班延误和空中交通流量分布。仿真了未来最大航班量下的空中地面情况。通过统计分析航班延误,找出限制该地区飞行流量的瓶颈所在。

  14. β-decay half-lives and β-delayed neutron emission probabilities of nuclei in the region A≲110, relevant for the r process

    Pereira, J.; Hennrich, S.; Aprahamian, A.; Arndt, O.; Becerril, A.; Elliot, T.; Estrade, A.; Galaviz, D.; Kessler, R.; Kratz, K.-L.; Lorusso, G.; Mantica, P. F.; Matos, M.; Möller, P.; Montes, F.; Pfeiffer, B.; Schatz, H.; Schertz, F.; Schnorrenberger, L.; Smith, E.; Stolz, A.; Quinn, M.; Walters, W. B.; Wöhr, A.


    Measurements of β-decay properties of A≲110 r-process nuclei have been completed at the National Superconducting Cyclotron Laboratory at Michigan State University. β-decay half-lives for Y105, Zr106,107, and Mo111, along with β-delayed neutron emission probabilities of Y104, Mo109,110 and upper limits for Y105, Zr103-107, and Mo108,111 have been measured for the first time. Studies on the basis of the quasi-random-phase approximation are used to analyze the ground-state deformation of these nuclei.

  15. Beta-decay half-lives and beta-delayed neutron emission probabilities of nuclei in the region below A=110, relevant for the r-process

    Pereira, J; Aprahamian, A; Arndt, O; Becerril, A; Elliot, T; Estrade, A; Galaviz, D; Kessler, R; Kratz, K -L; Lorusso, G; Mantica, P F; Matos, M; Møller, P; Montes, F; Pfeiffer, B; Schatz, H; Schertz, F; Schnorrenberger, L; Smith, E; Stolz, A; Quinn, M; Walters, W B; Wöhr, A


    Measurements of the beta-decay properties of r-process nuclei below A=110 have been completed at the National Superconducting Cyclotron Laboratory, at Michigan State University. Beta-decay half-lives for Y-105, Zr-106,107 and Mo-111, along with beta-delayed neutron emission probabilities of Y-104, Mo-109,110 and upper limits for Y-105, Zr-103,104,105,106,107 and Mo-108,111 have been measured for the first time. Studies on the basis of the quasi-random phase approximation are used to analyze the ground-state deformation of these nuclei.

  16. Beta-decay half-lives and beta-delayed neutron emisison probabilities of nuclei in the region A. 110, relevant for the r-process

    Moller, Peter [Los Alamos National Laboratory; Pereira, J [MSU; Hennrich, S [MSU; Aprahamian, A [UNIV OF NOTRE DAME; Arndt, O [GERMANY; Becerril, A [MSU; Elliot, T [MSU; Estrade, A [MSU; Galaviz, D [MSU; Kessler, R [UNIV MAINZ; Kratz, K - L [GERMANY; Lorusso, G [MSU; Mantica, P F [MSU; Matos, M [MSU; Montes, F [MSU; Pfeiffer, B [UNIV MAINZ; Schatz, F [MSU; Schnorrenberger, L [GERMANY; Smith, E [MSU; Stolz, A [MSU; Quinn, M [UNIV OF NOTRE DAME; Walters, W B [UNIV OF MARYLAND; Wohr, A [UNIV OF NOTRE DAME


    Measurements of the {beta}-decay properties of A {approx}< 110 r-process nuclei have been completed at the National Superconducting Cyclotron Laboratory, at Michigan State University. {beta}-decay half-lives for {sup 105}Y, {sup 106,107}Zr and {sup 108,111}Mo, along with ,B-delayed neutron emission probabilities of 104Y, 109,11OMo and upper limits for 105Y, 103-107Zr and 108,111 Mo have been measured for the first time. Studies on the basis of the quasi-random phase approximation are used to analyze the ground-state deformation of these nuclei.


    Lionello, Roberto; Linker, Jon A.; Mikić, Zoran [Predictive Science, Inc., 9990 Mesa Rim Rd., Ste. 170, San Diego, CA 92121-3933 (United States); Alexander, Caroline E.; Winebarger, Amy R., E-mail:, E-mail:, E-mail:, E-mail:, E-mail: [NASA Marshall Space Flight Center, ZP 13, Huntsville, AL 35805 (United States)


    The light curves of solar coronal loops often peak first in channels associated with higher temperatures and then in those associated with lower temperatures. The delay times between the different narrowband EUV channels have been measured for many individual loops and recently for every pixel of an active region observation. The time delays between channels for an active region exhibit a wide range of values. The maximum time delay in each channel pair can be quite large, i.e., >5000 s. These large time delays make-up 3%–26% (depending on the channel pair) of the pixels where a trustworthy, positive time delay is measured. It has been suggested that these time delays can be explained by simple impulsive heating, i.e., a short burst of energy that heats the plasma to a high temperature, after which the plasma is allowed to cool through radiation and conduction back to its original state. In this paper, we investigate whether the largest observed time delays can be explained by this hypothesis by simulating a series of coronal loops with different heating rates, loop lengths, abundances, and geometries to determine the range of expected time delays between a set of four EUV channels. We find that impulsive heating cannot address the largest time delays observed in two of the channel pairs and that the majority of the large time delays can only be explained by long, expanding loops with photospheric abundances. Additional observations may rule out these simulations as an explanation for the long time delays. We suggest that either the time delays found in this manner may not be representative of real loop evolution, or that the impulsive heating and cooling scenario may be too simple to explain the observations, and other potential heating scenarios must be explored.

  18. Source Coding When the Side Information May Be Delayed

    Simeone, Osvaldo


    For memoryless sources, delayed side information at the decoder does not improve the rate-distortion function. However, this is not the case for more general sources with memory, as demonstrated by a number of works focusing on the special case of (delayed) feedforward. In this paper, a setting is studied in which the encoder is potentially uncertain about the delay with which measurements of the side information are acquired at the decoder. Assuming a hidden Markov model for the sources, at first, a single-letter characterization is given for the set-up where the side information delay is arbitrary and known at the encoder, and the reconstruction at the destination is required to be (near) lossless. Then, with delay equal to zero or one source symbol, a single-letter characterization is given of the rate-distortion region for the case where side information may be delayed or not, unbeknownst to the encoder. The characterization is further extended to allow for additional information to be sent when the side ...

  19. Delayed childbearing.

    Francis, H H


    In many Western nations, including England and Wales, Sweden, and the US, there is a current trend towards delayed childbearing because of women's pursuit of a career, later marriage, a longer interval between marriage and the 1st birth, and the increasing number of divorcees having children in a 2nd marriage. Wives of men in social classes I and II in England and Wales are, on average, having their 1st child at 27.9 years, 1.6 years later than in 1973, and in social classes IV and V, 1.0 years later than in 1973, at a mean age of 23.7 years. Consequently, the total period fertility rate for British women aged 30-34 years, 35-39 years, and 40 and over increased by 4%, 2%, and 4%, respectively, between 1982-83, in contrast to reductions of 2% and 3%, respectively, in the 15-19 year and 20-24 year age groups, with the 25-29-year-olds remaining static. The average maternal mortality for all parties in England and Wales during 1976-78 was 106/million for adolescents, 70.4/million for 20-24 year-olds, and 1162/million for those aged 40 years and older. The specific obstetric and allied conditions which increase with age are the hypertensive diseases of pregnancy, hemorrhage, pulmonary embolism, abortion, cardiac disease, caesarean section, ruptured uterus, and amniotic fluid embolism. The Swedish Medical Birth Registry of all live births and perinatal deaths since 1973 has shown that the risk of late fetal death is significantly greater in women aged 30-39 years than in those of the same parity and gravidity aged 20-24 years. The risk of giving birth to low birth weight babies preterm and at term and of premature labor are similarly increased. The early neonatal death rate also was increased for primigravidas and nulliparas in the 30-39 year age group but not in parous women. This is, in part, due to the rise in incidence of fetal abnormalities with advancing maternal age because of chromosomal and nonchromosomal anomalies. These also appear to be the cause of the

  20. 山地延迟番茄晚疫病的发生与防治%Occurrence and Prevention of Delay Tomato Late Blight in Mountainous Region



    Symptom expression,etiology,occurred conditions of tomato late blight were elabrated.Causes of the outbreak on tomato late blight were analyzed.And in view of the characteristics of tomato late blight,prevention measures were put forward,so as to provide reference for delay tomato growers to forecast and prevention of the disease in Qingzhen City.%阐述了番茄晚疫病症状表现尧病原尧发生条件,分析该病重发原因,并针对番茄晚疫病的危害特点,提出防治措施,以期为清镇市延迟番茄种植户预测和防治该病提供参考。

  1. Stabilisation for switched linear systems with time-varying delay and input saturation

    Chen, Yonggang; Fei, Shumin; Zhang, Kanjian


    This article investigates the stabilisation problems for continuous-time and discrete-time switched systems with time-varying delay and saturated control input. Based on dwell time switching signals and multiple Lyapunov functional method, stabilisation conditions are well obtained in the context of linear matrix inequalities. To estimate attractive regions as large as possible, the feasibility problems are translated into optimisation problems. In addition, the corresponding results are presented for linear time-delay systems and switched delay-free systems, which improve and supplement some existing ones in the literature. Finally, numerical examples and simulations are given to illustrate the effectiveness and values of the proposed results.

  2. Effective multicasting algorithm for dynamic membership with delay constraint

    CHEN Lin; XU Zheng-quan


    This paper proposes an effective heuristic algorithm for dynamic multicast routing with delay-constrained DDMR.The tree constructed by DDMR has the following characteristics: (1) multicast tree changes with the dynamic memberships; (2)the cost of the tree is as small as possible at each node addition/removal event; (3) all of the path delay meet a fixed delay constraint;(4) minimal perturbation to an existing tree. The proposed algorithm is based on "damage" and "usefulness" concepts proposed in previous work, and has a new parameter bf(Balancing Factor) for judging whether or not to rearrange a tree region when membership changes. Mutation operation in Genetic Algorithm (GA) is also employed to find an attached node for a new adding node.Simulation showed that our algorithm performs well and is better than static heuristic algorithms, in term of cost especially.

  3. Relative impact of previous disturbance history on the likelihood of additional disturbance in the Northern United States Forest Service USFS Region

    Hernandez, A. J.


    The Landsat archive is increasingly being used to detect trends in the occurrence of forest disturbance. Beyond information about the amount of area affected, forest managers need to know if and how disturbance regimes change. The National Forest System (NFS) has developed a comprehensive plan for carbon monitoring that requires a detailed temporal mapping of forest disturbances across 75 million hectares. A long-term annual time series that shows the timing, extent, and type of disturbance beginning in 1990 and ending in 2011 has been prepared for several USFS Regions, including the Northern Region. Our mapping starts with an automated detection of annual disturbances using a time series of historical Landsat imagery. Automated detections are meticulously inspected, corrected and labeled using various USFS ancillary datasets. The resulting maps of verified disturbance show the timing and types are fires, harvests, insect activity, disease, and abiotic (wind, drought, avalanche) damage. Also, the magnitude of each change event is modeled in terms of the proportion of canopy cover lost. The sequence of disturbances for every pixel since 1990 has been consistently mapped and is available across the entirety of NFS. Our datasets contain sufficient information to describe the frequency of stand replacement, as well as how often disturbance results in only a partial loss of canopy. This information provides empirical insight into how an initial disturbance may predispose a stand to further disturbance, and it also show a climatic signal in the occurrence of processes such as fire and insect epidemics. Thus, we have the information to model the likelihood of occurrence of certain disturbances after a given event (i.e. if we have a fire in the past what does that do to the likelihood of occurrence of insects in the future). Here, we explore if previous disturbance history is a reliable predictor of additional disturbance in the future and we present results of applying

  4. Facilitating tolerance of delayed reinforcement during functional communication training.

    Fisher, W W; Thompson, R H; Hagopian, L P; Bowman, L G; Krug, A


    Few clinical investigations have addressed the problem of delayed reinforcement. In this investigation, three individuals whose destructive behavior was maintained by positive reinforcement were treated using functional communication training (FCT) with extinction (EXT). Next, procedures used in the basic literature on delayed reinforcement and self-control (reinforcer delay fading, punishment of impulsive responding, and provision of an alternative activity during reinforcer delay) were used to teach participants to tolerate delayed reinforcement. With the first case, reinforcer delay fading alone was effective at maintaining low rates of destructive behavior while introducing delayed reinforcement. In the second case, the addition of a punishment component reduced destructive behavior to near-zero levels and facilitated reinforcer delay fading. With the third case, reinforcer delay fading was associated with increases in masturbation and head rolling, but prompting and praising the individual for completing work during the delay interval reduced all problem behaviors and facilitated reinforcer delay fading.

  5. Critical region in 2q31.2q32.3 deletion syndrome: Report of two phenotypically distinct patients, one with an additional deletion in Alagille syndrome region

    Ferreira Susana


    Full Text Available Abstract Background Standard cytogenetic analysis has revealed to date more than 30 reported cases presenting interstitial deletions involving region 2q31-q32, but with poorly defined breakpoints. After the postulation of 2q31.2q32.3 deletion as a clinically recognizable disorder, more patients were reported with a critical region proposed and candidate genes pointed out. Results We report two female patients with de novo chromosome 2 cytogenetically visible deletions, one of them with an additional de novo deletion in chromosome 20p12.2p12.3. Patient I presents a 16.8 Mb deletion in 2q31.2q32.3 while patient II presents a smaller deletion of 7 Mb in 2q32.1q32.3, entirely contained within patient I deleted region, and a second 4 Mb deletion in Alagille syndrome region. Patient I clearly manifests symptoms associated with the 2q31.2q32.3 deletion syndrome, like the muscular phenotype and behavioral problems, while patient II phenotype is compatible with the 20p12 deletion since she manifests problems at the cardiac level, without significant dysmorphisms and an apparently normal psychomotor development. Conclusions Whereas Alagille syndrome is a well characterized condition mainly caused by haploinsufficiency of JAG1 gene, with manifestations that can range from slight clinical findings to major symptoms in different domains, the 2q31.2q32.3 deletion syndrome is still being delineated. The occurrence of both imbalances in reported patient II would be expected to cause a more severe phenotype compared to the individual phenotype associated with each imbalance, which is not the case, since there are no manifestations due to the 2q32 deletion. This, together with the fact that patient I deleted region overlaps previously reported cases and patient II deletion is outside this common region, reinforces the existence of a critical region in 2q31.3q32.1, between 181 to 185 Mb, responsible for the clinical phenotype.

  6. Epidemiology of delayed ejaculation.

    Di Sante, Stefania; Mollaioli, Daniele; Gravina, Giovanni Luca; Ciocca, Giacomo; Limoncin, Erika; Carosa, Eleonora; Lenzi, Andrea; Jannini, Emmanuele A


    A large body of literature on diminished ejaculatory disorders has been generated without the use of a clear diagnostic definition. Many studies have not distinguished between the orgasm and ejaculation disorders leading to doubtful results. Delayed ejaculation (DE) is one of the diminished ejaculatory disorders, which range from varying delays in ejaculatory latency to a complete inability to ejaculate. The present review is aimed at providing a comprehensive overview of the current knowledge on the definition and epidemiology of diminished ejaculatory disorders. We focus on the acquired diseases, such as benign prostatic hyperplasia (BPH) and specific drug regimens that may cause an iatrogenic form of ejaculatory disorder. In addition, the impact of aging is discussed since the prevalence of DE appears to be moderately but positively related to age. Finally, we also focus on the importance of the hormonal milieu on male ejaculation. To date, evidence on the endocrine control of ejaculation is derived from small clinical trials, but the evidence suggests that hormones modulate the ejaculatory process by altering its overall latency.

  7. Proposed Ice Flow, Given 200m and 400m Additional Ice in the Allan Hills Region, Antarctica: Implications for Meteorite Concentration

    Traub-Metlay, S.; Cassidy, W. A.


    The Allan Hills-David Glacier region contains some of the most highly populated meteorite stranding surfaces in Antarctica. Nearly 2000 meteorites have to date been collected from the icefields associated with the Allan Hills, and nearly 1500 from areas around Elephant Moraine. While much attention has been focused on the current geological and glaciological conditions of these stranding surfaces, less work has been done concerning what they may have looked like in the past, when ice thicknesses may have been greater. In this study, conjectural maps of the current Allan Hills area with 200 meters and 400 meters of additional ice cover each are analyzed for probable regional and local ice flow patterns. A dramatic decrease in ice thickness over a relatively brief period of time could result either from climatic change or a geologically rapid regional uplift. Delisle and Sievers (1991) noted that the valley between the Allan Hills Main Icefield and the Allan Hills resembles a half-graben resulting from east-west extensional tectonics, and that the mesa-like bedrock features associated with the Near Western and Mid Western Icefields resemble fault blocks. They concluded that the Allan Hills area icefields may have become active stranding surfaces as a result of a regional uplift within the past 1-2 million years, assuming a current rate of uplift in the Allan Hills region of ~100 meters/million years. Whether the cause was climatic or tectonic, generalized maps of current ice contours plus 400 and 200 meters ice may provide views of what the Allan Hills region looked like just before activation of the modern meteorite stranding surfaces (Figs. 1 and 2). At an ice thickness greater by 400 meters, ice could flow smoothly over the Allan Hills and would drain down to the Mawson Glacier via the Odell Glacier, east of the Allan Hills; down the Manhaul Bay depression between the east and west arms of Allan Hills; and down the half-graben discovered by Delisle and Sievers

  8. Delaying vortex breakdown by waves

    Yao, M. F.; Jiang, L. B.; Wu, J. Z.; Ma, H. Y.; Pan, J. Y.


    The effect of spiral waves on delaying vortex breakdown in a tube is studied experimentally and theoretically. When a harmonic oscillation was imposed on one of guiding vanes in the tube, the breakdown was observed to be postponed appreciately. According to the generalized Lagrangian mean theory, proper forcing spiral waves may produce an additional streaming momentum, of which the effect is favorable and similar to an axial suction at downstream end. The delayed breakdown position is further predicted by using nonlinear wave theory. Qualitative agreement between theory and experiment is obtained, and experimental comparison of the effects due to forcing spiral wave and axial suction is made.

  9. Synchronization transitions on scale-free neuronal networks due to finite information transmission delays

    Wang, Qingyun; Perc, Matjaž; Duan, Zhisheng; Chen, Guanrong


    We investigate front propagation and synchronization transitions in dependence on the information transmission delay and coupling strength over scale-free neuronal networks with different average degrees and scaling exponents. As the underlying model of neuronal dynamics, we use the efficient Rulkov map with additive noise. We show that increasing the coupling strength enhances synchronization monotonously, whereas delay plays a more subtle role. In particular, we found that depending on the inherent oscillation frequency of individual neurons, regions of irregular and regular propagating excitatory fronts appear intermittently as the delay increases. These delay-induced synchronization transitions manifest as well-expressed minima in the measure for spatial synchrony, appearing at every multiple of the oscillation frequency. Larger coupling strengths or average degrees can broaden the region of regular propagating fronts by a given information transmission delay and further improve synchronization. These results are robust against variations in system size, intensity of additive noise, and the scaling exponent of the underlying scale-free topology. We argue that fine-tuned information transmission delays are vital for assuring optimally synchronized excitatory fronts on complex neuronal networks and, indeed, they should be seen as important as the coupling strength or the overall density of interneuronal connections. We finally discuss some biological implications of the presented results.

  10. Time Delay and Long-Range Connection Induced Synchronization Transitions in Newman-Watts Small-World Neuronal Networks

    Qian, Yu


    The synchronization transitions in Newman-Watts small-world neuronal networks (SWNNs) induced by time delay and long-range connection (LRC) probability have been investigated by synchronization parameter and space-time plots. Four distinct parameter regions, that is, asynchronous region, transition region, synchronous region, and oscillatory region have been discovered at certain LRC probability as time delay is increased. Interestingly, desynchronization is observed in oscillatory region. More importantly, we consider the spatiotemporal patterns obtained in delayed Newman-Watts SWNNs are the competition results between long-range drivings (LRDs) and neighboring interactions. In addition, for moderate time delay, the synchronization of neuronal network can be enhanced remarkably by increasing LRC probability. Furthermore, lag synchronization has been found between weak synchronization and complete synchronization as LRC probability is a little less than 1.0. Finally, the two necessary conditions, moderate time delay and large numbers of LRCs, are exposed explicitly for synchronization in delayed Newman-Watts SWNNs. PMID:24810595

  11. Time delay and long-range connection induced synchronization transitions in Newman-Watts small-world neuronal networks.

    Qian, Yu


    The synchronization transitions in Newman-Watts small-world neuronal networks (SWNNs) induced by time delay τ and long-range connection (LRC) probability P have been investigated by synchronization parameter and space-time plots. Four distinct parameter regions, that is, asynchronous region, transition region, synchronous region, and oscillatory region have been discovered at certain LRC probability P = 1.0 as time delay is increased. Interestingly, desynchronization is observed in oscillatory region. More importantly, we consider the spatiotemporal patterns obtained in delayed Newman-Watts SWNNs are the competition results between long-range drivings (LRDs) and neighboring interactions. In addition, for moderate time delay, the synchronization of neuronal network can be enhanced remarkably by increasing LRC probability. Furthermore, lag synchronization has been found between weak synchronization and complete synchronization as LRC probability P is a little less than 1.0. Finally, the two necessary conditions, moderate time delay and large numbers of LRCs, are exposed explicitly for synchronization in delayed Newman-Watts SWNNs.

  12. Effects of Addition of Systemic Tramadol or Adjunct Tramadol to Lidocaine Used for Intravenous Regional Anesthesia in Patients Undergoing Hand Surgery.

    Yektaş, Abdulkadir; Gümüş, Funda; Karayel, Abdulhalim; Alagöl, Ayşin


    Intravenous regional anesthesia (IVRA) is used in outpatient hand surgery as an easily applicable and cost-effective technique with clinical advantages. The present study aimed to investigate the effects of addition of systemic tramadol or adjunct tramadol to lidocaine for IVRA in patients undergoing hand surgery. American Society of Anesthesiologists (ASA) I-II patients (n = 60) who underwent hand surgery were included. For this purpose, only lidocaine (LDC), lidocaine+adjunct tramadol (LDC+TRA group), or lidocaine+systemic tramadol (LDC+SysTRA group) was administered to the patients for IVRA and the groups were compared in terms of onset and recovery time of sensory and motor blocks, quality of anesthesia, and the degree of intraoperative and postoperative pain. The onset time of sensorial block was significantly shorter in the LDC+TRA group than that in the LDC+SysTRA group. The motor block recovery time was significantly shorter in the LDC+SysTRA group than that in the LDC+TRA and LDC groups. Administration of tramadol as an adjunct showed some clinical benefits by providing a shorter onset time of sensory and motor block, decreasing pain and analgesic requirement, and improving intraoperative conditions during IVRA. It was determined that systemic tramadol administration had no superiority.

  13. Effects of Addition of Systemic Tramadol or Adjunct Tramadol to Lidocaine Used for Intravenous Regional Anesthesia in Patients Undergoing Hand Surgery

    Abdulkadir Yektaş


    Full Text Available Intravenous regional anesthesia (IVRA is used in outpatient hand surgery as an easily applicable and cost-effective technique with clinical advantages. The present study aimed to investigate the effects of addition of systemic tramadol or adjunct tramadol to lidocaine for IVRA in patients undergoing hand surgery. American Society of Anesthesiologists (ASA I-II patients (n=60 who underwent hand surgery were included. For this purpose, only lidocaine (LDC, lidocaine+adjunct tramadol (LDC+TRA group, or lidocaine+systemic tramadol (LDC+SysTRA group was administered to the patients for IVRA and the groups were compared in terms of onset and recovery time of sensory and motor blocks, quality of anesthesia, and the degree of intraoperative and postoperative pain. The onset time of sensorial block was significantly shorter in the LDC+TRA group than that in the LDC+SysTRA group. The motor block recovery time was significantly shorter in the LDC+SysTRA group than that in the LDC+TRA and LDC groups. Administration of tramadol as an adjunct showed some clinical benefits by providing a shorter onset time of sensory and motor block, decreasing pain and analgesic requirement, and improving intraoperative conditions during IVRA. It was determined that systemic tramadol administration had no superiority.

  14. Delayed translational silencing of ceruloplasmin transcript in gamma interferon-activated U937 monocytic cells: role of the 3' untranslated region

    Mazumder, B.; Fox, P. L.


    Ceruloplasmin (Cp) is an acute-phase protein with ferroxidase, amine oxidase, and pro- and antioxidant activities. The primary site of Cp synthesis in human adults is the liver, but it is also synthesized by cells of monocytic origin. We have shown that gamma interferon (IFN-gamma) induces the synthesis of Cp mRNA and protein in monocytic cells. We now report that the induced synthesis of Cp is terminated by a mechanism involving transcript-specific translational repression. Cp protein synthesis in U937 cells ceased after 16 h even in the presence of abundant Cp mRNA. RNA isolated from cells treated with IFN-gamma for 24 h exhibited a high in vitro translation rate, suggesting that the transcript was not defective. Ribosomal association of Cp mRNA was examined by sucrose centrifugation. When Cp synthesis was high, i.e., after 8 h of IFN-gamma treatment, Cp mRNA was primarily associated with polyribosomes. However, after 24 h, when Cp synthesis was low, Cp mRNA was primarily in the nonpolyribosomal fraction. Cytosolic extracts from cells treated with IFN-gamma for 24 h, but not for 8 h, contained a factor which blocked in vitro Cp translation. Inhibitor expression was cell type specific and present in extracts of human cells of myeloid origin, but not in several nonmyeloid cells. The inhibitory factor bound to the 3' untranslated region (3'-UTR) of Cp mRNA, as shown by restoration of in vitro translation by synthetic 3'-UTR added as a "decoy" and detection of a binding complex by RNA gel shift analysis. Deletion mapping of the Cp 3'-UTR indicated an internal 100-nucleotide region of the Cp 3'-UTR that was required for complex formation as well as for silencing of translation. Although transcript-specific translational control is common during development and differentiation and global translational control occurs during responses to cytokines and stress, to our knowledge, this is the first report of translational silencing of a specific transcript following cytokine

  15. Dimensional reduction of nonlinear time delay systems

    M. S. Fofana


    infinite-dimensional problem without the assumption of small time delay. This dimensional reduction is illustrated in this paper with the delay versions of the Duffing and van der Pol equations. For both nonlinear delay equations, transcendental characteristic equations of linearized stability are examined through Hopf bifurcation. The infinite-dimensional nonlinear solutions of the delay equations are decomposed into stable and centre subspaces, whose respective dimensions are determined by the linearized stability of the transcendental equations. Linear semigroups, infinitesimal generators, and their adjoint forms with bilinear pairings are the additional candidates for the infinite-dimensional reduction.

  16. The Right Delay

    Datadien, A.H.R.; Haselager, W.F.G.; Sprinkhuizen-Kuyper, I.G.


    Axonal conduction delays should not be ignored in simulations of spiking neural networks. Here it is shown that by using axonal conduction delays, neurons can display sensitivity to a specific spatio-temporal spike pattern. By using delays that complement the firing times in a pattern, spikes can ar

  17. Modeling delayed processes in biological systems

    Feng, Jingchen; Sevier, Stuart A.; Huang, Bin; Jia, Dongya; Levine, Herbert


    Delayed processes are ubiquitous in biological systems and are often characterized by delay differential equations (DDEs) and their extension to include stochastic effects. DDEs do not explicitly incorporate intermediate states associated with a delayed process but instead use an estimated average delay time. In an effort to examine the validity of this approach, we study systems with significant delays by explicitly incorporating intermediate steps. We show that such explicit models often yield significantly different equilibrium distributions and transition times as compared to DDEs with deterministic delay values. Additionally, different explicit models with qualitatively different dynamics can give rise to the same DDEs revealing important ambiguities. We also show that DDE-based predictions of oscillatory behavior may fail for the corresponding explicit model.

  18. Second Malignancies After Adjuvant Radiation Therapy for Early Stage Breast Cancer: Is There Increased Risk With Addition of Regional Radiation to Local Radiation?

    Hamilton, Sarah Nicole [Department of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia (Canada); Department of Radiation Oncology, British Columbia Cancer Agency-Vancouver Centre, Vancouver, British Columbia (Canada); Tyldesley, Scott, E-mail: [Department of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia (Canada); Department of Radiation Oncology, British Columbia Cancer Agency-Vancouver Centre, Vancouver, British Columbia (Canada); Li, Dongdong [Cancer Control Research Department, British Columbia Cancer Agency-Vancouver Centre, Vancouver, British Columbia (Canada); Olson, Robert [Department of Radiation Oncology, British Columbia Cancer Agency-Centre for the North, Prince George, British Columbia (Canada); McBride, Mary [Cancer Control Research Department, British Columbia Cancer Agency-Vancouver Centre, Vancouver, British Columbia (Canada)


    Purpose: This study was undertaken to determine whether there was an increased risk of second malignancies (SM), particularly lung cancer, in early stage breast cancer patients treated with the addition of nodal fields to breast and/or chest wall radiation therapy (RT). Materials and Methods: Subjects were stage I/II female breast cancer patients 20 to 79 years of age, diagnosed between 1989 and 2005 and treated with adjuvant RT at our institution. Patients were included if they survived and did not have SM within 3 years of diagnosis. Standardized incidence ratios (SIR) with 95% confidence intervals (CI) were calculated to compare SM incidence to cancer incidence in the general sex- and age-matched populations. Secondary malignancy risks in patients treated with local RT (LRT) to the breast/chest wall were compared to those in patients treated with locoregional RT (LRRT) to the breast/chest wall and regional nodes, using multivariate regression analysis (MVA) to account for covariates. Results: The cohort included 12,836 patients with a median follow-up of 8.4 years. LRRT was used in 18% of patients. The SIR comparing patients treated with LRT to the general population was 1.29 (CI: 1.21-1.38). No statistically significant increased incidence of in-field malignancies (SIR, 1.04; CI: 0.87-1.23) and lung cancers (SIR, 1.06; CI: 0.88-1.26) was detected. The SIR comparing patients treated with LRRT to the general population was 1.39 (CI: 1.17-1.64). No statistically significant increased incidence of in-field malignancies (SIR, 1.26; CI: 0.77-1.94) and lung cancers (SIR, 1.27; CI: 0.76-1.98) was detected. On MVA comparing LRRT to LRT, the adjusted hazard ratio was 1.20 for in-field malignancies (CI: 0.68-2.16) and 1.26 for lung cancer (CI: 0.67-2.36). The excess attributable risk (EAR) to regional RT was 3.1 per 10,000 person years (CI: −8.7 to 9.9). Conclusions: No statistically significant increased risk of second malignancy was detected after LRRT relative to

  19. Addition of positively charged tripeptide to N-terminus of the Fos basic region leucine zipper domain: implications on DNA bending, affinity, and specificity.

    Mahmoudi, T; Sarkar, B


    GKH-Fos(139-211)/Jun(248-334) (GKH: glycine-lysine-histidine) is a modified Fos/Jun heterodimer designed to contain a metal binding motif in the form of a GKH tripeptide at the amino terminus of Fos bZIP domain dimerized with the Jun basic region leucine zipper (bZIP) domain. We examined the effect of the addition of positively charged GKH motif to the N-terminus of Fos(139-211) on the DNA binding characteristics of the Fos(139-211)/Jun(248-334) heterodimer. Binding studies indicate that while the nonspecific DNA binding affinity of the GKH modified heterodimer increases 4-fold, it specifically binds the activating protein-1 (AP-1) site 6-fold less tightly than the control unmodified counterpart. Furthermore, helical phasing analysis indicates that GKH-Fos(139-211)/Jun(248-334) and control Fos(139-211)/Jun(248-334) both bend the DNA at the AP-1 site toward the minor groove. However, due to the presence of the positively charged GKH motif on Fos, the degree of the induced bend by GKH- Fos(139-211)/Jun(248-334) is greater than that induced by the unmodified Fos/Jun heterodimer. Our results suggest that the unfavorable energetic cost of the increased DNA bending by GKH-Fos(139-211)/Jun(248-334) results in a decrease in both specificity and affinity of binding of the heterodimer to the AP-1 site. These findings may have important implications in protein design as well in our understanding of DNA bending and factors responsible for the functional specificity of different members of the bZIP family of transcription factors.

  20. Discovery of a Plains Caldera Complex and Extinct Lava Lake in Arabia Terra, Mars: Implications for the Discovery of Additional Highland Volcanic Source Regions

    Bleacher, Jacob; Michalski, Joseph


    Several irregularly shaped topographic depressions occur near the dichotomy boundary in northern Arabia Terra, Mars. The geomorphology of these features suggests that they formed by collapse, opposed to meteor impact. At least one depression (approx.55 by 85 km) displays geologic features indicating a complex, multi-stage collapse history. Features within and around the collapse structure indicate volcanic processes. The complex occurs within Hesperian ridged plains of likely volcanic origin and displays no crater rim or evidence for ejecta. Instead the depression consists of a series of circumferential graben and down-dropped blocks which also display upper surfaces similar to ridged plain lavas. Large blocks within the depression are tilted towards the crater center, and display graben that appear to have originally been linked with circumferential graben outside of the complex related to earlier collapse events. A nearly 700 m high mound exists along a graben within the complex that might be a vent. The deepest depression displays two sets of nearly continuous terraces, which we interpret as high-stands of a drained lava lake. These features appear similar to the black ledge described during the Kilauea Iki eruption in 1959. A lacustrine origin for the terraces seems unlikely because of the paucity of channels found in or around the depression that could be linked to aqueous surface processes. In addition, there is no obvious evidence for lacustrine sediments within the basin. Together with the presence of significant faulting that is indicative of collapse we conclude that this crater complex represents a large caldera formed in the Late Noachian to Early Hesperian. Other linear and irregular depressions in the region also might be linked to ancient volcanism. If that hypothesis is correct, it suggests that northern Arabia Terra could contain a large, previously unrecognized highland igneous province. Evacuation of magma via explosive and effusive activity

  1. Food additives

    ... this page: // Food additives To use the sharing features on this page, please enable JavaScript. Food additives are substances that become part of a food ...

  2. Controlling a time-delay system using multiple delay feedback control

    Qi Wei; Zhang Yan; Wang Ying-Hai


    In this paper multiple delay feedback control (MDFC) with different and independent delay times is shown to be an efficient method for stabilizing fixed points in finite-dimensional dynamical systems. Whether MDFC can be applied to infinite-dimensional systems has been an open question. In this paper we find that for infinite-dimensional systems modelled by delay differential equations, MDFC works well for stabilizing (unstable) steady states in long-, moderate-and short-time delay regions, in particular for the hyperchaotic case.

  3. Delayed emergence after anesthesia.

    Tzabazis, Alexander; Miller, Christopher; Dobrow, Marc F; Zheng, Karl; Brock-Utne, John G


    In most instances, delayed emergence from anesthesia is attributed to residual anesthetic or analgesic medications. However, delayed emergence can be secondary to unusual causes and present diagnostic dilemmas. Data from clinical studies is scarce and most available published material is comprised of case reports. In this review, we summarize and discuss less common and difficult to diagnose reasons for delayed emergence and present cases from our own experience or reference published case reports/case series. The goal is to draw attention to less common reasons for delayed emergence, identify patient populations that are potentially at risk and to help anesthesiologists identifying a possible cause why their patient is slow to wake up.

  4. VideoLat: An Extensible Tool for Multimedia Delay Measurements

    Jansen, A.J.


    When using a videoconferencing system there will always be a delay from sender to receiver. Such delays affect human communication, and therefore knowing the delay is a major factor in judging the expected quality of experience of the conferencing system. Additionally, for implementors, tuning the s

  5. Delay Banking for Managing Air Traffic

    Green, Steve


    Delay banking has been invented to enhance air-traffic management in a way that would increase the degree of fairness in assigning arrival, departure, and en-route delays and trajectory deviations to aircraft impacted by congestion in the national airspace system. In delay banking, an aircraft operator (airline, military, general aviation, etc.) would be assigned a numerical credit when any of their flights are delayed because of an air-traffic flow restriction. The operator could subsequently bid against other operators competing for access to congested airspace to utilize part or all of its accumulated credit. Operators utilize credits to obtain higher priority for the same flight, or other flights operating at the same time, or later, in the same airspace, or elsewhere. Operators could also trade delay credits, according to market rules that would be determined by stakeholders in the national airspace system. Delay banking would be administered by an independent third party who would use delay banking automation to continually monitor flights, allocate delay credits, maintain accounts of delay credits for participating airlines, mediate bidding and the consumption of credits of winning bidders, analyze potential transfers of credits within and between operators, implement accepted transfers, and ensure fair treatment of all participating operators. A flow restriction can manifest itself in the form of a delay in assigned takeoff time, a reduction in assigned airspeed, a change in the position for the aircraft in a queue of all aircraft in a common stream of traffic (e.g., similar route), a change in the planned altitude profile for an aircraft, or change in the planned route for the aircraft. Flow restrictions are typically imposed to mitigate traffic congestion at an airport or in a region of airspace, particularly congestion due to inclement weather, or the unavailability of a runway or region of airspace. A delay credit would be allocated to an operator of a

  6. Ionospheric delay gradient monitoring for GBAS by GPS stations near Suvarnabhumi airport, Thailand

    Rungraengwajiake, Sarawoot; Supnithi, Pornchai; Saito, Susumu; Siansawasdi, Nattapong; Saekow, Apitep


    Ground-based augmentation system (GBAS) is an important augmentation system that provides the differential corrections and integrity information from the reference stations to the aircrafts for precision approach and landing. It is known that the nonuniform ionospheric characteristics called "ionospheric delay gradient" can cause the errors in differential corrections degrading the accuracy and safety level if they are undetected by the reference stations. Since the characteristics of the ionosphere are different for each region, the ionospheric delay gradient observations in equatorial and low-latitude regions are necessary for developing the suitable ionospheric threat models. The purpose of this work is to analyze the ionospheric delay gradients observed by three GPS stations near Suvarnabhumi airport in Bangkok, Thailand, which is located in the low-latitude region. The ionospheric irregularities in this region are mainly caused by the plasma bubble, which usually occurs after sunset. The GPS data with plasma bubble occurrence during the September equinox 2011 and 2012 are therefore analyzed. In addition, the data analysis procedure utilizing the rate of total electron content change index for this region is proposed. The results show that the ionospheric delay gradients observed in the west-east direction appear higher than the south-north direction, varying from 28 to 178 mm/km during plasma bubble occurrences.

  7. Ral GTPase interacts with the N-terminal in addition to the C-terminal region of PLC-delta1.

    Grujic, Ognjen; Bhullar, Rajinder P


    Previously, we have shown that RalA, a calmodulin (CaM)-binding protein, binds to the C2 region in the C-terminal of PLC-delta1, and increases its enzymatic activity. Since PLC-delta1 contains a CaM-like region in its N-terminus, we have investigated if RalA can also bind to the N-terminus of PLC-delta1. Therefore, we created a GST-PLC-delta1 construct consisting of the first 294 amino acids of PLC-delta1 (GST-PLC-delta1(1-294)). In vitro binding experiments confirmed that PLC-delta1(1-294) was capable of binding directly to RalA. W-7 coupled to polyacrylamide beads bound pure PLC-delta1, demonstrating that PLC-delta1 contains a CaM-like region. Competition assays with W-7, peptides representing RalA and the newly identified RalB CaM-binding regions, or the IQ peptide from PLC-delta1 were able to inhibit RalA binding to PLC-delta1(1-294). This study demonstrates that there are two binding sites for RalA in PLC-delta1 and provides further insight into the role of Ral GTPase in the regulation of PLC-delta1 function.

  8. Consideration of QRS complex in addition to ST-segment abnormalities in the estimated "risk region" during acute anterior myocardial infarction

    van Hellemond, Irene E G; Bouwmeester, Sjoerd; Olson, Charles W


    a falsely low estimated total MaR if determined by using ST segment-based methods. The purpose of this study was to investigate if consideration of the abnormalities in the QRS complex, in addition to those in the ST segment, provides a more accurate estimated total MaR during anterior AMI than...

  9. Recovery of delay time from time series based on the nearest neighbor method

    Prokhorov, M. D.; Ponomarenko, V. I.; Khorev, V. S.


    We propose a method for the recovery of delay time from time series of time-delay systems. The method is based on the nearest neighbor analysis. The method allows one to reconstruct delays in various classes of time-delay systems including systems of high order, systems with several coexisting delays, and nonscalar time-delay systems. It can be applied to time series heavily corrupted by additive and dynamical noise.

  10. Recovery of delay time from time series based on the nearest neighbor method

    Prokhorov, M.D., E-mail: [Saratov Branch of Kotel' nikov Institute of Radio Engineering and Electronics of Russian Academy of Sciences, Zelyonaya Street, 38, Saratov 410019 (Russian Federation); Ponomarenko, V.I. [Saratov Branch of Kotel' nikov Institute of Radio Engineering and Electronics of Russian Academy of Sciences, Zelyonaya Street, 38, Saratov 410019 (Russian Federation); Department of Nano- and Biomedical Technologies, Saratov State University, Astrakhanskaya Street, 83, Saratov 410012 (Russian Federation); Khorev, V.S. [Department of Nano- and Biomedical Technologies, Saratov State University, Astrakhanskaya Street, 83, Saratov 410012 (Russian Federation)


    We propose a method for the recovery of delay time from time series of time-delay systems. The method is based on the nearest neighbor analysis. The method allows one to reconstruct delays in various classes of time-delay systems including systems of high order, systems with several coexisting delays, and nonscalar time-delay systems. It can be applied to time series heavily corrupted by additive and dynamical noise.

  11. Additivity dominance

    Paul Rozin


    Full Text Available Judgments of naturalness of foods tend to be more influenced by the process history of a food, rather than its actual constituents. Two types of processing of a ``natural'' food are to add something or to remove something. We report in this study, based on a large random sample of individuals from six countries (France, Germany, Italy, Switzerland, UK and USA that additives are considered defining features of what makes a food not natural, whereas ``subtractives'' are almost never mentioned. In support of this, skim milk (with major subtraction of fat is rated as more natural than whole milk with a small amount of natural vitamin D added. It is also noted that ``additives'' is a common word, with a synonym reported by a native speaker in 17 of 18 languages, whereas ``subtractive'' is lexicalized in only 1 of the 18 languages. We consider reasons for additivity dominance, relating it to omission bias, feature positive bias, and notions of purity.

  12. commensurate point delays

    M. de la Sen


    nominal controller is maintained. In the current approach, the finite spectrum assignment is only considered as a particular case of the designer's choice of a (delay-dependent arbitrary spectrum assignment objective.

  13. Stability and Relative Stability of Linear Systems with Many Constant Time Delays. Ph.D. Thesis

    Barker, Larry Keith


    A method of determining the stability of linear systems with many constant time delays is developed. This technique, an extension of the tau-decomposition method, is used to examine not only the stability but also the relative stability of retarded systems with many delays and a class of neutral equations with one delay. Analytical equations are derived for partitioning the delay space of a retarded system with two time delays. The stability of the system in each of the regions defined by the partitioning curves in the parameter plane is determined using the extended tau-decomposition method. In addition, relative stability boundaries are defined using the extended tau-decompositon method in association with parameter plane techniques. Several applications of the extended tau-decomposition method are presented and compared with stability results obtained from other analyses. In all cases the results obtained using the method outlined herein coincide with and extend those of previous investigations. The extended tau-decomposition method applied to systems with time delays requires less computational effort and yields more complete stability analyses than previous techniques.

  14. A new species of Amara (Coleoptera, Carabidae, Zabrini) from Sichuan Province, China, with additional records for other Amara species from the region

    Hieke, Fritz; Kavanaugh, David H.; Liang, Hongbin


    Abstract A new species, Amara (Bradytulus) shalulishanica Hieke & Kavanaugh, sp. n. (type locality: Haizishan Yakou, 29.47366°N, 100.21921°E, 4623 m, Shalulishan, Zhuosang Township, Litang County, Sichuan Province, China) is described and diagnosed. Additional records are provided for 16 other Amara species, each of which represents one of five different geographical distribution types, which are discussed. PMID:23378815

  15. A new species of Amara (Coleoptera, Carabidae, Zabrini from Sichuan Province, China, with additional records for other Amara species from the region

    Fritz Hieke


    Full Text Available A new species, Amara (Bradytulus shalulishanica Hieke & Kavanaugh, sp. n. (type locality: Haizishan Yakou, 29.47366°N, 100.21921°E, 4623 m, Shalulishan, Dishan Township, Litang County, Sichuan Province, China is described and diagnosed. Additional records are provided for 16 other Amara species, each of which represents one of five different geographical distribution types, which are discussed.

  16. Time Delay Cosmography

    Treu, Tommaso; Marshall, Philip J.


    Gravitational time delays, observed in strong lens systems where the variable background source is multiply-imaged by a massive galaxy in the foreground, provide direct measurements of cosmological distance that are very complementary to other cosmographic probes. The success of the technique depends on the availability and size of a suitable sample of lensed quasars or supernovae, precise measurements of the time delays, accurate modeling of the gravitational potential of the main deflector,...

  17. Delayed radiation neuropathy

    Nagashima, T.; Miyamoto, K.; Beppu, H.; Hirose, K.; Yamada, K. (Tokyo Metropolitan Neurological Hospital (Japan))


    A case of cervical plexus neuropathy was reported in association with chronic radio-dermatitis, myxedema with thyroid adenoma and epiglottic tumor. A 38-year-old man has noticed muscle weakness and wasting of the right shoulder girdle since age 33. A detailed history taking revealed a previous irradiation to the neck because of the cervical lymphadenopathy at age 10 (X-ray 3,000 rads), keroid skin change at age 19, obesity and edema since 26, and hoarseness at 34. Laryngoscopic examination revealed a tumor on the right vocal cord, diagnosed as benign papilloma by histological study. In addition, there were chronic radio-dermatitis around the neck, primary hypothyroidism with a benign functioning adenoma on the right lobe of the thyroid, the right phrenic nerve palsy and the right recurrent nerve palsy. All these lesions were considered to be the late sequellae of radiation to the neck in childhood. Other neurological signs were weakness and amyotrophy of the right shoulder girdle with patchy sensory loss, and areflexia of the right arm. Gross power was fairly well preserved in the right hand. EMG showed neurogenic changes in the tested muscles, suggesting a peripheral nerve lesion. Nerve conduction velocities were normal. No abnormal findings were revealed by myelography and spinal CT. The neurological findings of the patient were compatible with the diagnosis of middle cervical plexus palsy apparently due to late radiation effect. In the literature eight cases of post-radiation neuropathy with a long latency have been reported. The present case with the longest latency after the radiation should be included in the series of the reported cases of ''delayed radiation neuropathy.'' (author).

  18. Decreased frontal, striatal and cerebellar activation in adults with ADHD during an adaptive delay discounting task.

    Ortiz, Nick; Parsons, Aisling; Whelan, Robert; Brennan, Katie; Agan, Maria L F; O'Connell, Redmond; Bramham, Jessica; Garavan, Hugh


    An important characteristic of childhood attention-deficit/hyperactivity disorder (ADHD) is a bias towards small immediate versus larger delayed rewards, but it is not known if this symptom is also a feature of adult ADHD. A delay-discounting task was administered to participants with adult ADHD and a comparison group in conjunction with functional magnetic resonance imaging. Participants responded to a series of questions that required judgments between small sums of money available immediately and larger sums obtained after a temporal delay. Question parameters were adjusted by an adaptive algorithm designed to converge on each participant's discounting indifference point, an individual set point at which there is equal valuation of both choices. In all participants, robust task activation was observed in regions previously identified in functional imaging studies of delay discounting. However, adults with ADHD showed less task activation in a number of regions including the dorsolateral prefrontal cortex, superior frontal gyrus, anterior cingulate, caudate nucleus and declive of the cerebellum. Additionally, the degree to which a participant discounted delayed rewards was inversely related to task activation in the cerebellum. The results suggest that the bias towards immediate rewards in childhood ADHD may not persist behaviorally, but instead present in adulthood as alterations in frontostriatal and frontocerebellar networks.

  19. Spin-orbit delays in photoemission

    Jordan, I.; Huppert, M.; Pabst, S.; Kheifets, A. S.; Baykusheva, D.; Wörner, H. J.


    Attosecond delays between photoelectron wave packets emitted from different electronic shells are now well established. Is there any delay between electrons originating from the same electronic shell but leaving the cation in different fine-structure states? This question is relevant for all attosecond photoemission studies involving heavy elements, be it atoms, molecules or solids. We answer this fundamental question by measuring energy-dependent delays between photoelectron wave packets associated with the 3/2 2P and 1/2 2P components of the electronic ground states of Xe+ and Kr+. We observe delays reaching up to 33 ±6 as in the case of Xe. Our results are compared with two state-of-the-art theories. Whereas both theories quantitatively agree with the results obtained for Kr, neither of them fully reproduces the experimental results in Xe. Performing delay measurements very close to the ionization thresholds, we compare the agreement of several analytical formulas for the continuum-continuum delays with experimental data. Our results show an important influence of spin-orbit coupling on attosecond photoionization delays, highlight the requirement for additional theory development, and offer a precision benchmark for such work.

  20. Dragonflies and damselflies (Insecta: Odonata of the northeastern region of Bangladesh with five new additions to the Odonata fauna of Bangladesh

    M. Kawsar Khan


    Full Text Available Odonata were surveyed in one reserve forest, two national parks, one Eco Park, one lake and one University campus in the northeastern region of Bangladesh from March 2014 to March 2015.  A total of 64 species of Anisoptera and Zygoptera belonging to 41 genera under seven families were recorded.  Among them 45 species and 19 genera were new records for the study area.  Two species of Anisoptera, i.e., Anax indicus Lieftinck, 1942 and Gynacantha khasiaca MacLachlan, 1896, and three species of Zygoptera i.e., Matrona nigripectus Selys, 1879, Agriocnemis kalinga Nair & Subramanian, 2014, and Prodasineura laidlawii Forster, 1907 were recorded for the first time from Bangladesh.  

  1. Potlining Additives

    Rudolf Keller


    In this project, a concept to improve the performance of aluminum production cells by introducing potlining additives was examined and tested. Boron oxide was added to cathode blocks, and titanium was dissolved in the metal pool; this resulted in the formation of titanium diboride and caused the molten aluminum to wet the carbonaceous cathode surface. Such wetting reportedly leads to operational improvements and extended cell life. In addition, boron oxide suppresses cyanide formation. This final report presents and discusses the results of this project. Substantial economic benefits for the practical implementation of the technology are projected, especially for modern cells with graphitized blocks. For example, with an energy savings of about 5% and an increase in pot life from 1500 to 2500 days, a cost savings of $ 0.023 per pound of aluminum produced is projected for a 200 kA pot.

  2. Additivity dominance


    Judgments of naturalness of foods tend to be more influenced by the process history of a food, rather than its actual constituents. Two types of processing of a ``natural'' food are to add something or to remove something. We report in this study, based on a large random sample of individuals from six countries (France, Germany, Italy, Switzerland, UK and USA) that additives are considered defining features of what makes a food not natural, whereas ``subtractives'' are almost never mentioned....

  3. Tunable delay time and Hartman effect in graphene magnetic barriers

    Ban, Yue; Wang, Lin-Jun [School of Materials Science and Engineering, Shanghai University, Shanghai 200444 (China); Chen, Xi, E-mail: [Department of Physics, Shanghai University, Shanghai 200444 (China)


    Tunable group delay and Hartman effect have been investigated for massless Dirac electrons in graphene magnetic barriers. In the presence of magnetic field, dwell time is found to be equal to net group delay plus the group delay contributing from the lateral shifts. The group delay times are discussed in both cases of normal and oblique incidence, to clarify the nature of Hartman effect. In addition, the group delay in transmission can be modulated from subluminality to superluminality by adjusting the magnetic field, which may also lead to potential applications in graphene-based microelectronics.

  4. Delay modeling in logic simulation

    Acken, J. M.; Goldstein, L. H.


    As digital integrated circuit size and complexity increases, the need for accurate and efficient computer simulation increases. Logic simulators such as SALOGS (SAndia LOGic Simulator), which utilize transition states in addition to the normal stable states, provide more accurate analysis than is possible with traditional logic simulators. Furthermore, the computational complexity of this analysis is far lower than that of circuit simulation such as SPICE. An eight-value logic simulation environment allows the use of accurate delay models that incorporate both element response and transition times. Thus, timing simulation with an accuracy approaching that of circuit simulation can be accomplished with an efficiency comparable to that of logic simulation. 4 figures.

  5. The WNT2 Gene Polymorphism Associated with Speech Delay Inherent to Autism

    Lin, Ping-I; Chien, Yi-Ling; Wu, Yu-Yu; Chen, Chia-Hsiang; Gau, Susan Shur-Fen; Huang, Yu-Shu; Liu, Shih-Kai; Tsai, Wen-Che; Chiu, Yen-Nan


    Previous evidence suggests that language function is modulated by genetic variants on chromosome 7q31-36. However, it is unclear whether this region harbors loci that contribute to speech delay in autism. We previously reported that the WNT2 gene located on 7q31 was associated with the risk of autism. Additionally, two other genes on 7q31-36,…

  6. Engineering the expression and biochemical characteristics of recombinant Candida rugosa LIP2 lipase by removing the additional N-terminal peptide and regional codon optimization.

    Chang, Shu-Wei; Li, Chia-Fang; Lee, Guan-Chiun; Yeh, Tzunuan; Shaw, Jei-Fu


    Candida rugosa lipase (CRL), an important industrial enzyme, has been established, containing several different isoforms which were encoded by the high-identity lip gene family (lip1 to lip7). In this study, we compared the expression and biochemical characterization with three different engineered lip2 constructions in the yeast Pichia pastoris. Our results showed that lip2 (lip2) has an overall improvement of 50% higher production yield (1.446 U/mL) relative to that of nflip2 (0.964 U/mL) at 7 days of cultivation time. Codon-optimized lip2 (colip2) has a 2.3-fold higher production yield (2.182 U/mL) compared to that of lip2 (noncodon-optimized; 1.446 U/mL) and nflip2 (0.964 U/mL), with a cultivation time of 5 days. This finding demonstrated that the removal of the N-terminus and the regional codon optimization of the lip2 gene fragment at the 5' end can greatly increase the expression level of recombinant LIP2 in the P. pastoris system. The distinct biochemical properties of our purified recombinant nfLIP2 and LIP2 suggested that they are potentially useful for various industrial applications.

  7. Information transfer via implicit encoding with delay time modulation in a time-delay system

    Kye, Won-Ho, E-mail: [Korean Intellectual Property Office, Government Complex Daejeon Building 4, 189, Cheongsa-ro, Seo-gu, Daejeon 302-701 (Korea, Republic of)


    A new encoding scheme for information transfer with modulated delay time in a time-delay system is proposed. In the scheme, the message is implicitly encoded into the modulated delay time. The information transfer rate as a function of encoding redundancy in various noise scales is presented and it is analyzed that the implicit encoding scheme (IES) has stronger resistance against channel noise than the explicit encoding scheme (EES). In addition, its advantages in terms of secure communication and feasible applications are discussed. -- Highlights: ► We propose new encoding scheme with delay time modulation. ► The message is implicitly encoded with modulated delay time. ► The proposed scheme shows stronger resistance against channel noise.

  8. No Time to Delay Life Education in Newly-Established Regional Universities%新建地方本科高校生命教育的迫切性

    赵桂英; 张象林


    There are a lot of accidents such as incidental death, suicide, killing and abuse of animals, indicating that the primary education paid little attention to life education, so there is no time to delay life education in universities. The newly-established regional universities take up one third of the total number of u- niversities with students taking up more than a half proportion. Students in those universities tend to be weak in comprehensive quality and academic background, and selfcontemptuous and self-conceited at the same time, so they are easily to go extreme. We have the obligation to enhance life education in those universities. There are many ways we can take, like developing life security and value education, gratitude education, frustration education, death education, mental health education and physical education to improve the young students' living ability and happiness index and cultivate them into all-round practical talents of high-quality%高校学生意外死亡、轻生、杀人、虐待动物等事件时有发生,提示我们基础教育阶段的生命教育效果不佳,提醒我们生命教育刻不容缓。而新建地方本科高校占据了高校总数的三分之一,学生比例超过一半以上,这些学生由于综合素质与文化基础相对较为薄弱,自卑与自大心理并存,对生命价值的认识更易陷入偏颇,因此,在新建地方本科高校必须加强生命教育。新建地方本科高校可以通过多种途径,开展生命安全、生命价值观教育,开展感恩教育、挫折教育、死亡教育,心理健康教育及身体健康训练、健康检测等项活动,从而提升青年学生的生存技能和幸福指数,培养他们成为素质高、发展全面的应用型人才。

  9. Impaired mitochondrial functions in organophosphate induced delayed neuropathy in rats.

    Masoud, Anwar; Kiran, Ravi; Sandhir, Rajat


    Acute exposure to organophosphates induces a delayed neurodegenerative condition known as organophosphate-induced delayed neuropathy (OPIDN). The mechanism of OPIDN has not been fully understood as it does not involve cholinergic crisis. The present study has been designed to evaluate the role of mitochondrial dysfunctions in the development of OPIDN. OPIDN was induced in rats by administering acute dose of monocrotophos (MCP, 20 mg/kg body weight, orally) or dichlorvos (DDVP, 200 mg/kg body weight, subcutaneously), 15-20 min after treatment with antidotes [atropine (20 mg/kg body weight) and 2-PAM (100 mg/kg body weight) intraperitoneally]. MDA levels were observed to be higher and thiol content was lower in mitochondria from brain regions of OP exposed animals. This was accompanied by decreased activities of the mitochondrial enzymes; NADH dehydrogenase, succinate dehydrogenase, and cytochrome oxidase. In addition, mitochondrial functions assessed by MTT reduction also confirmed mitochondrial dysfunctions following development of OPIDN. The spatial long-term memory evaluated using elevated plus-maze test was observed to be deficit in OPIDN. The results suggest impaired mitochondrial functions as a mechanism involved in the development of organophosphate induced delayed neuropathy.

  10. Time Delay Cosmography

    Treu, Tommaso


    Gravitational time delays, observed in strong lens systems where the variable background source is multiply-imaged by a massive galaxy in the foreground, provide direct measurements of cosmological distance that are very complementary to other cosmographic probes. The success of the technique depends on the availability and size of a suitable sample of lensed quasars or supernovae, precise measurements of the time delays, accurate modeling of the gravitational potential of the main deflector, and our ability to characterize the distribution of mass along the line of sight to the source. We review the progress made during the last 15 years, during which the first competitive cosmological inferences with time delays were made, and look ahead to the potential of significantly larger lens samples in the near future.

  11. Delayed Random Relays

    Ohira, Toru


    We present here a system with collection of random walks relaying a signal in one dimension with a presence of a delay. We are interested in the time for a signal to travel from one end (start) to the other end (finish) of the lined group of random walkers. It is found that there is an optimal number of walkers for the signal to travel fastest if the delay is present. We discuss implications of this model and associated behaviors to physical and biological systems.

  12. Approximation of distributed delays

    Lu, Hao; Eberard, Damien; Simon, Jean-Pierre


    We address in this paper the approximation problem of distributed delays. Such elements are convolution operators with kernel having bounded support, and appear in the control of time-delay systems. From the rich literature on this topic, we propose a general methodology to achieve such an approximation. For this, we enclose the approximation problem in the graph topology, and work with the norm defined over the convolution Banach algebra. The class of rational approximates is described, and a constructive approximation is proposed. Analysis in time and frequency domains is provided. This methodology is illustrated on the stabilization control problem, for which simulations results show the effectiveness of the proposed methodology.

  13. Consideration of QRS complex in addition to ST-segment abnormalities in the estimation of the "risk region" during acute anterior or inferior myocardial infarction.

    Vervaat, F E; Bouwmeester, S; van Hellemond, I E G; Wagner, G S; Gorgels, A P M


    The myocardial area at risk (MaR) is an important aspect in acute ST-elevation myocardial infarction (STEMI). It represents the myocardium at the onset of the STEMI that is ischemic and could become infarcted if no reperfusion occurs. The MaR, therefore, has clinical value because it gives an indication of the amount of myocardium that could potentially be salvaged by rapid reperfusion therapy. The most validated method for measuring the MaR is (99m)Tc-sestamibi SPECT, but this technique is not easily applied in the clinical setting. Another method that can be used for measuring the MaR is the standard ECG-based scoring system, Aldrich ST score, which is more easily applied. This ECG-based scoring system can be used to estimate the extent of acute ischemia for anterior or inferior left ventricular locations, by considering quantitative changes in the ST-segment. Deviations in the ST-segment baseline that occur following an acute coronary occlusion represent the ischemic changes in the transmurally ischemic myocardium. In most instances however, the ECG is not available at the very first moments of STEMI and as times passes the ischemic myocardium becomes necrotic with regression of the ST-segment deviation along with progressive changes of the QRS complex. Thus over the time course of the acute event, the Aldrich ST score would be expected to progressively underestimate the MaR, as was seen in studies with SPECT as gold standard; anterior STEMI (r=0.21, p=0.32) and inferior STEMI (r=0.17, p=0.36). Another standard ECG-based scoring system is the Selvester QRS score, which can be used to estimate the final infarct size by considering the quantitative changes in the QRS complex. Therefore, additional consideration of the Selvester QRS score in the acute phase could potentially provide the "component" of infarcted myocardium that is missing when the Aldrich ST score alone is used to determine the MaR in the acute phase, as was seen in studies with SPECT as gold

  14. Delayed traumatic diaphragmatic hernia

    Lu, Jing; Wang, Bo; Che, Xiangming; Li, Xuqi; Qiu, Guanglin; He, Shicai; Fan, Lin


    Abstract Background: Traumatic diaphragmatic hernias (TDHs) are sometimes difficult to identify at an early stage and can consequently result in diagnostic delays with life-threatening outcomes. It is the aim of this case study to highlight the difficulties encountered with the earlier detection of traumatic diaphragmatic hernias. Methods: Clinical data of patients who received treatment for delayed traumatic diaphragmatic hernias in registers of the First Affiliated Hospital of Xi’an Jiaotong University from 1998 to 2014 were analyzed retrospectively. Results: Six patients were included in this study. Left hemidiaphragm was affected in all of them. Most of the patients had a history of traffic accident and 1 a stab-penetrating injury. The interval from injury to developing symptoms ranged from 2 to 11 years (median 5 years). The hernial contents included the stomach, omentum, small intestine, and colon. Diaphragmatic injury was missed in all of them during the initial managements. All patients received operations once the diagnosis of delayed TDH was confirmed, and no postoperative mortality was detected. Conclusions: Delayed TDHs are not common, but can lead to serious consequences once occurred. Early detection of diaphragmatic injuries is crucial. Surgeons should maintain a high suspicion for injuries of the diaphragm in cases with abdominal or lower chest traumas, especially in the initial surgical explorations. We emphasize the need for radiographical follow-up to detect diaphragmatic injuries at an earlier stage. PMID:27512848

  15. Delayed breast implant reconstruction

    Hvilsom, Gitte B.; Hölmich, Lisbet R.; Steding-Jessen, Marianne;


    We evaluated the association between radiation therapy and severe capsular contracture or reoperation after 717 delayed breast implant reconstruction procedures (288 1- and 429 2-stage procedures) identified in the prospective database of the Danish Registry for Plastic Surgery of the Breast during...... reconstruction approaches other than implants should be seriously considered among women who have received radiation therapy....

  16. 'No delays achiever'.


    The latest version of the NHS Institute for Innovation and Improvement's 'no delays achiever', a web based tool created to help NHS organisations achieve the 18-week target for GP referrals to first treatment, is available at

  17. Ignition Delay Studies on Hypergolic Fuel Grains

    S. R. Jain


    Full Text Available The ignition delays of several solid hypergolic fuel compositions, casted using various polymeric binders, or as melts, have been determined with fuming nitric acid as oxidizer. The ignition delays of various hypergolic fuel compositions increase drasticaliy on casting with binders like. carboxyl or hydroxyl termninated polybutadiene. Fuel grains cast using some newly syhthesised epoxy  resins with other ingrcdients, such as curing agent, magnesium powder and fuel, have short ignition delays of the order of 200 ms, and also good mechanical strength. Increasing the amount of binder in the composition retards the hypergolicity of the rain. Similar studies have been made on melt-cast systems using low melting hypergolic fuels for casting fuel powders. The ignition delays of the melt-cast grains, are longer than those determined taking the composition in the powder form. The effect of highly hypergolic additives, and metal powders, on the ignition delay of the cast compositions has been determined. Grains having good mechanical strength and short ignition delays have been obtained by optimising the fuel grain composition.

  18. Stability analysis of a class of fractional delay differential equations

    Sachin B Bhalekar


    In this paper we analyse stability of nonlinear fractional order delay differential equations of the form $D^{} y(t) = af(y(t - )) - {\\text{by}} (t)$, where $D^{}$ is a Caputo fractional derivative of order 0 < ≤ 1. We describe stability regions using critical curves. To explain the proposed theory, we discuss fractional order logistic equation with delay.

  19. Various Forms of Project Delay in the Construction Industry


    Project delay can be defined as an incident that causes extended time in order to complete all or part of a particular project successfully. In other words, delay is the time overrun, either ahead of the date for project completion specified by the contract or further than the extensive contract period where an addition of time has been granted. It should be pointed out that the project delay in the construction industry is a universal or large-scale observable fact affectin...

  20. Consensus networks with time-delays over finite fields

    Li, Xiuxian; Su, Housheng; Chen, Michael Z. Q.


    In this paper, we investigate the consensus problem in networks with time-delays over finite fields. The delays are categorised into three cases: single constant delay, multiple constant delays, and time-varying bounded delays. For all cases, some sufficient and necessary conditions for consensus are derived. Furthermore, assuming that the communication graph is strongly connected, some of the obtained necessary conditions reveal that the conditions for consensus with time-delays over finite fields depend not only on the diagonal entries but also on the off-diagonal entries, something that is intrinsically distinct from the case over real numbers (where having at least one nonzero diagonal entry is a sufficient and necessary condition to guarantee consensus). In addition, it is shown that delayed networks cannot achieve consensus when the interaction graph is a tree if the corresponding delay-free networks cannot reach consensus, which is consistent with the result over real numbers. As for average consensus, we show that it can never be achieved for delayed networks over finite fields, although it indeed can be reached under several conditions for delay-free networks over finite fields. Finally, networks with time-varying delays are discussed and one sufficient condition for consensus is presented by graph-theoretic method.

  1. Complex Dynamics of a Continuous Bertrand Duopoly Game Model with Two-Stage Delay

    Junhai Ma


    Full Text Available This paper studies a continuous Bertrand duopoly game model with two-stage delay. Our aim is to investigate the influence of delay and weight on the complex dynamic characteristics of the system. We obtain the bifurcation point of the system respect to delay parameter by calculating. In addition, the dynamic properties of the system are simulated by power spectrum, attractor, bifurcation diagram, the largest Lyapunov exponent, 3D surface chart, 4D Cubic Chart, 2D parameter bifurcation diagram, and 3D parameter bifurcation diagram. The results show that the stability of the system depends on the delay and weight, in order to maintain stability of price and ensure the firm profit, the firms must control the parameters in the reasonable region. Otherwise, the system will lose stability, and even into chaos, which will cause fluctuations in prices, the firms cannot be profitable. Finally, the chaos control of the system is carried out by a control strategy of the state variables’ feedback and parameter variation, which effectively avoid the damage of chaos to the economic system. Therefore, the results of this study have an important practical significance to make decisions with multi-stage delay for oligopoly firms.

  2. Stability domains of the delay and PID coefficients for general time-delay systems

    Almodaresi, Elham; Bozorg, Mohammad; Taghirad, Hamid D.


    Time delays are encountered in many physical systems, and they usually threaten the stability and performance of closed-loop systems. The problem of determining all stabilising proportional-integral-derivative (PID) controllers for systems with perturbed delays is less investigated in the literature. In this study, the Rekasius substitution is employed to transform the system parameters to a new space. Then, the singular frequency (SF) method is revised for the Rekasius transformed system. A novel technique is presented to compute the ranges of time delay for which stable PID controller exists. This stability range cannot be readily computed from the previous methods. Finally, it is shown that similar to the original SF method, finite numbers of singular frequencies are sufficient to compute the stable regions in the space of time delay and controller coefficients.

  3. Delay-independent stabilization for teleoperation with time varying delay

    Fujita, Hiroyuki; Namerikawa, Toru


    This paper deals with the stability for nonlinear teleoperation with time varying communication delays. The proposed method is passivity-based controllers with time varying gains which depend on the rate of change of time varying delay. In our proposed method, stability condition is independent of the magnitude of the communication delay and the damping of the system. The delay-independent stability is shown via Lyapunov stability methods. Several experimental results show the effectiveness o...

  4. $\\beta$-delayed proton decays near the proton drip line

    Xu, S W; Huang, W X; Li, Z K; Pan Qiang Yan; Shu, N C; Wang, K; Wang, X D; Xie, Y X; Xing, Y B; Xu, F R; Yu, Y; 10.1103/PhysRevC.71.054318


    We briefly reviewed and summarized the experimental study on beta - delayed proton decays published by our group over the last 8 years, namely the experimental observation of beta -delayed proton decays of nine new nuclides in the rare-earth region near the proton drip line and five nuclides in the mass 90 region with N approximately=Z by utilizing the p- gamma coincidence technique in combination with a He-jet tape transport system. In addition, important technical details of the experiments were provided. The experimental results were compared to the theoretical predictions of some nuclear models, resulting in the following conclusions. (1) The experimental half- lives for /sup 85/Mo, /sup 92/Rh, as well as the predicted "waiting point" nuclei /sup 89/Ru and /sup 93/Pd were 5-10 times longer than the macroscopic-microscopic model predictions of Moller et al. At. Data Nucl. Data Tables 66,131(1997). These data considerably influenced the predictions of the mass abundances of the nuclides produced in the rp p...

  5. Delayed Sequential Coding of Correlated Sources

    Ma, Nan; Ishwar, Prakash


    Motivated by video coding applications, we study the problem of sequential coding of correlated sources with (noncausal) encoding and/or decoding frame-delays. The fundamental tradeoffs between individual frame rates, individual frame distortions, and encoding/decoding frame-delays are derived in terms of a single-letter information-theoretic characterization of the rate-distortion region for general inter-frame source correlations and certain types of (potentially frame-specific and coupled) single-letter fidelity criteria. For video sources which are spatially stationary memoryless and temporally Gauss--Markov, MSE frame distortions, and a sum-rate constraint, our results expose the optimality of differential predictive coding among all causal sequential coders. Somewhat surprisingly, causal sequential encoding with one-step delayed noncausal sequential decoding can exactly match the sum-rate-MSE performance of joint coding for all nontrivial MSE-tuples satisfying certain positive semi-definiteness conditio...

  6. [Delayed post effort muscle soreness].

    Coudreuse, J M; Dupont, P; Nicol, C


    Muscle intolerance to exercise may result from different processes. Diagnosis involves confirming first the source of pain, then potential pathological myalgia. Delayed-onset muscle soreness (DOMS), commonly referred as tiredness, occurs frequently in sport. DOMS usually develops 12-48 h after intensive and/or unusual eccentric muscle action. Symptoms usually involve the quadriceps muscle group but may also affect the hamstring and triceps surae groups. The muscles are sensitive to palpation, contraction and passive stretch. Acidosis, muscle spasm and microlesions in both connective and muscle tissues may explain the symptoms. However, inflammation appears to be the most common explanation. Interestingly, there is strong evidence that the progression of the exercise-induced muscle injury proceeds no further in the absence of inflammation. Even though unpleasant, DOMS should not be considered as an indicator of muscle damage but, rather, a sign of the regenerative process, which is well known to contribute to the increased muscle mass. DOMS can be associated with decreased proprioception and range of motion, as well as maximal force and activation. DOMS disappears 2-10 days before complete functional recovery. This painless period is ripe for additional joint injuries. Similarly, if some treatments are well known to attenuate DOMS, none has been demonstrated to accelerate either structural or functional recovery. In terms of the role of the inflammatory process, these treatments might even delay overall recovery.

  7. Theoretical Delay Time Distributions

    Nelemans, Gijs; Bours, Madelon


    We briefly discuss the method of population synthesis to calculate theoretical delay time distributions of type Ia supernova progenitors. We also compare the results of the different research groups and conclude that although one of the main differences in the results for single degenerate progenitors is the retention efficiency with which accreted hydrogen is added to the white dwarf core, this cannot explain all the differences.

  8. Theoretical Delay Time Distributions

    Nelemans, Gijs; Toonen, Silvia; Bours, Madelon


    We briefly discuss the method of population synthesis to calculate theoretical delay time distributions of Type Ia supernova progenitors. We also compare the results of different research groups and conclude that, although one of the main differences in the results for single degenerate progenitors is the retention efficiency with which accreted hydrogen is added to the white dwarf core, this alone cannot explain all the differences.

  9. Geometric Time Delay Interferometry

    Vallisneri, Michele


    The space-based gravitational-wave observatory LISA, a NASA-ESA mission to be launched after 2012, will achieve its optimal sensitivity using Time Delay Interferometry (TDI), a LISA-specific technique needed to cancel the otherwise overwhelming laser noise in the inter-spacecraft phase measurements. The TDI observables of the Michelson and Sagnac types have been interpreted physically as the virtual measurements of a synthesized interferometer. In this paper, I present Geometric TDI, a new an...

  10. Time-Delay Interferometry

    Dhurandhar Sanjeev V.; Tinto Massimo


    Equal-arm interferometric detectors of gravitational radiation allow phase measurements many orders of magnitude below the intrinsic phase stability of the laser injecting light into their arms. This is because the noise in the laser light is common to both arms, experiencing exactly the same delay, and thus cancels when it is differenced at the photo detector. In this situation, much lower level secondary noises then set overall performance. If, however, the two arms have different lengths (...

  11. Numerical Investigation of Noise Enhanced Stability Phenomenon in a Time-Delayed Metastable System

    JIA Zheng-Lin


    @@ The transient properties of a time-delayed metastable system subjected to the additive white noise are investigated by means of the stochastic simulation method. The noise enhanced stability phenomenon (NES) can be observed in this system and the effect of the delay time on the NES shows a critical behaviour, i.e., there is a critical value of the delay time Tc ≈ 1, above which the time delay enhances the NES effect with the delay time increasing and below which the time delay weakens the NES effect as the delay time increases.

  12. Time-Delay Interferometry

    Massimo Tinto


    Full Text Available Equal-arm detectors of gravitational radiation allow phase measurements many orders of magnitude below the intrinsic phase stability of the laser injecting light into their arms. This is because the noise in the laser light is common to both arms, experiencing exactly the same delay, and thus cancels when it is differenced at the photo detector. In this situation, much lower level secondary noises then set the overall performance. If, however, the two arms have different lengths (as will necessarily be the case with space-borne interferometers, the laser noise experiences different delays in the two arms and will hence not directly cancel at the detector. In order to solve this problem, a technique involving heterodyne interferometry with unequal arm lengths and independent phase-difference readouts has been proposed. It relies on properly time-shifting and linearly combining independent Doppler measurements, and for this reason it has been called time-delay interferometry (TDI. This article provides an overview of the theory, mathematical foundations, and experimental aspects associated with the implementation of TDI. Although emphasis on the application of TDI to the Laser Interferometer Space Antenna (LISA mission appears throughout this article, TDI can be incorporated into the design of any future space-based mission aiming to search for gravitational waves via interferometric measurements. We have purposely left out all theoretical aspects that data analysts will need to account for when analyzing the TDI data combinations.

  13. Stimulus-dependent synchronization in delayed-coupled neuronal networks.

    Esfahani, Zahra G; Gollo, Leonardo L; Valizadeh, Alireza


    Time delay is a general feature of all interactions. Although the effects of delayed interaction are often neglected when the intrinsic dynamics is much slower than the coupling delay, they can be crucial otherwise. We show that delayed coupled neuronal networks support transitions between synchronous and asynchronous states when the level of input to the network changes. The level of input determines the oscillation period of neurons and hence whether time-delayed connections are synchronizing or desynchronizing. We find that synchronizing connections lead to synchronous dynamics, whereas desynchronizing connections lead to out-of-phase oscillations in network motifs and to frustrated states with asynchronous dynamics in large networks. Since the impact of a neuronal network to downstream neurons increases when spikes are synchronous, networks with delayed connections can serve as gatekeeper layers mediating the firing transfer to other regions. This mechanism can regulate the opening and closing of communicating channels between cortical layers on demand.

  14. Delayed Speech or Language Development

    ... to 2-Year-Old Delayed Speech or Language Development KidsHealth > For Parents > Delayed Speech or Language Development ... child is right on schedule. Normal Speech & Language Development It's important to discuss early speech and language ...

  15. Synchronization Stability in Weighted Complex Networks with Coupling Delays

    WANG Qing-Yun; DUAN Zhi-Sheng; CHEN Guan-Rong; LU Qi-Shao


    Realistic networks display not only a complex topological structure, but also a heterogeneous distribution of weights in connection strengths.In addition, the information spreading through a complex network is often associated with time delays due to the finite speed of signal transmission over a distance.Hence, the weighted complex network with coupling delays have meaningful implications in real world, and resultantly ga/ns increasing attention in various fields of science and engineering.Based on the theory of asymptotic stability of linear time-delay systems, synchronization stability of the weighted complex dynamical network with coupling delays is investigated, and simple criteria are obtained for both delay-independent and delay-dependent stabilities of synchronization states.The obtained criteria in this paper encompass the established results in the literature as special cases.Some examples are given to illustrate the theoretical results.

  16. Time Delay for the Dirac Equation

    Naumkin, Ivan; Weder, Ricardo


    We consider time delay for the Dirac equation. A new method to calculate the asymptotics of the expectation values of the operator {intlimits0 ^{∞}e^{iH0t}ζ(\\vert x\\vert /R) e^{-iH0t}dt}, as {R → ∞}, is presented. Here, H 0 is the free Dirac operator and {ζ(t)} is such that {ζ(t) = 1} for {0 ≤ t ≤ 1} and {ζ(t) = 0} for {t > 1}. This approach allows us to obtain the time delay operator {δ {T}(f)} for initial states f in {{H} 2^{3/2+ɛ}({R}3;{C}4)}, {ɛ > 0}, the Sobolev space of order {3/2+ɛ} and weight 2. The relation between the time delay operator {δ{T}(f)} and the Eisenbud-Wigner time delay operator is given. In addition, the relation between the averaged time delay and the spectral shift function is presented.

  17. Delay Choice vs. Delay Maintenance: Different Measures of Delayed Gratification in Capuchin Monkeys (Cebus apella)

    Addessi, Elsa; Paglieri, Fabio; Beran, Michael J.; Evans, Theodore A.; Macchitella, Luigi; De Petrillo, Francesca; Focaroli, Valentina


    Delaying gratification involves two components: (i) delay choice (selecting a delayed reward over an immediate one), and (ii) delay maintenance (sustaining the decision to delay gratification even if the immediate reward is available during the delay). In primates, two tasks most commonly have explored these components, the Intertemporal choice task and the Accumulation task. It is unclear whether these tasks provide equivalent measures of delay of gratification. Here, we compared the performance of the same capuchin monkeys, belonging to two study populations, between these tasks. We found only limited evidence of a significant correlation in performance. Consequently, in contrast to what is often assumed, our data provide only partial support to the hypothesis that these tasks provide equivalent measures of delay of gratification. PMID:23544770

  18. Delaying information search

    Yaniv Shani


    Full Text Available In three studies, we examined factors that may temporarily attenuate information search. People are generally curious and dislike uncertainty, which typically encourages them to look for relevant information. Despite these strong forces that promote information search, people sometimes deliberately delay obtaining valuable information. We find they may do so when they are concerned that the information might interfere with future pleasurable activities. Interestingly, the decision to search or to postpone searching for information is influenced not only by the value and importance of the information itself but also by well-being maintenance goals related to possible detrimental effects that negative knowledge may have on unrelated future plans.

  19. Pseudotumoral delayed cerebral radionecrosis

    Ciaudo-Lacroix, C.; Lapresle, J. (Centre Hospitalier de Bicetre, 94 - Le Kremlin-Bicetre (France))


    A 60 year-old woman with a scalp epithelioma underwent radiotherapy, the dose being 57 Gray. A first epileptic seizure occurred twenty months later. Neurological examination revealed signs of left hemisphere involvement. ..gamma..EG, angiography, CT scans, demonstrated a pseudotumoral avascular process. On account of the localisation, the patient being right-handed, no surgical procedure was performed. In spite of corticotherapy and anticonvulsive treatment, seizures recurred and neurological signs slowly progressed. The patient died, 22 months after the first seizure, of an associated disseminated carcinoma with cachexia. Neuropathological examination showed a massive lesion presenting all the features of delayed radionecrosis in the left hemisphere: situated mainly in the white matter; numerous vascular abnormalities; wide-spread demyelination; disappearance of oligoglial cells. The Authors recall the clinical and anatomical aspects of this condition for which the only successful treatment is surgical removal when location and size of the lesion permit. Finally, the mechanisms which have been proposed to explain this delayed cerebral radionecrosis are discussed.

  20. Synchronization of time-delay coupled pulse oscillators

    Klinshov, V.V., E-mail: vklin@mail.r [Institute of Applied Physics, Russian Academy of Sciences, 46 Ulyanov Str., 603950 Nizhny Novgorod (Russian Federation); Nekorkin, V.I. [Institute of Applied Physics, Russian Academy of Sciences, 46 Ulyanov Str., 603950 Nizhny Novgorod (Russian Federation)


    Research highlights: Oscillators can be synchronized via coupling with arbitrary large delay. Imposing of coupling delay may either result in delay-induced synchronization or delay-induced desynchronization. In-phase and antiphase synchronization zones alternate in parameter space. Two types of transitions between the in-phase and antiphase synchronization, i.e. phase-flip bifurcation and soft switching. - Abstract: We present a detailed study of the dynamics of pulse oscillators with time-delayed coupling. We get the return maps, obtain strict solutions and analyze their stability. For the case of two oscillators, a periodical structure of synchronization regions is found in parameter space, and the regions corresponding to in-phase and antiphase regimes alternate with growth of time delay. Two types of switching between in-phase and antiphase regimes are studied. We also show that for different parameters coupling delay may have synchronizing or desynchronizing effect. Another novel result is that phase locked regimes exist for arbitrary large values. The specificity of system dynamics with large delay is studied.

  1. Stability and delay sensitivity of neutral fractional-delay systems

    Xu, Qi; Shi, Min; Wang, Zaihua


    This paper generalizes the stability test method via integral estimation for integer-order neutral time-delay systems to neutral fractional-delay systems. The key step in stability test is the calculation of the number of unstable characteristic roots that is described by a definite integral over an interval from zero to a sufficient large upper limit. Algorithms for correctly estimating the upper limits of the integral are given in two concise ways, parameter dependent or independent. A special feature of the proposed method is that it judges the stability of fractional-delay systems simply by using rough integral estimation. Meanwhile, the paper shows that for some neutral fractional-delay systems, the stability is extremely sensitive to the change of time delays. Examples are given for demonstrating the proposed method as well as the delay sensitivity.

  2. A new method for analyzing diagnostic delay in gynecological cancer

    Vandborg, Mai Partridge; Edwards, Kasper; Kragtrup, Jakob;


    OBJECTIVE: The aim of this article is to present a new methodology to illustrate, understand, and measure delay in health care. The method is inspired by process mapping tools as analytical framework and demonstrates its usefulness for studying diagnostic delay in gynecological cancer. MATERIALS...... AND METHODS: Six women with a diagnostic delay of 6 weeks or more before treatment of gynecological cancer at a specialized regional department (the Department of Gynecology and Obstetrics, Odense University Hospital, Denmark) were included in the study. Maps of existing processes were performed for each...... to responsibilities and was shown to recurrently influence and contribute to the delay in the diagnostic process. Some important contributors to diagnostic delay in gynecological cancer, such as lack of cancer suspicion, competing diseases, negative test results, inexpedient referral patterns, and referrals without...

  3. A New Method for Analyzing Diagnostic Delay in Gynecological Cancer

    Vandborg, Mai Partridge; Edwards, Kasper; Kragstrup, Jakob;


    OBJECTIVE: The aim of this article is to present a new methodology to illustrate, understand, and measure delay in health care. The method is inspired by process mapping tools as analytical framework and demonstrates its usefulness for studying diagnostic delay in gynecological cancer. MATERIALS...... AND METHODS: Six women with a diagnostic delay of 6 weeks or more before treatment of gynecological cancer at a specialized regional department (the Department of Gynecology and Obstetrics, Odense University Hospital, Denmark) were included in the study. Maps of existing processes were performed for each...... to responsibilities and was shown to recurrently influence and contribute to the delay in the diagnostic process. Some important contributors to diagnostic delay in gynecological cancer, such as lack of cancer suspicion, competing diseases, negative test results, inexpedient referral patterns, and referrals without...

  4. Location Estimation using Delayed Measurements

    Bak, Martin; Larsen, Thomas Dall; Nørgård, Peter Magnus


    When combining data from various sensors it is vital to acknowledge possible measurement delays. Furthermore, the sensor fusion algorithm, often a Kalman filter, should be modified in order to handle the delay. The paper examines different possibilities for handling delays and applies a new techn...... technique to a sensor fusion system for estimating the location of an autonomous guided vehicle. The system fuses encoder and vision measurements in an extended Kalman filter. Results from experiments in a real environment are reported...

  5. On the Gravitomagnetic Time Delay

    Ciufolini, I.; Kopeikin, S.; Mashhoon, B.; Ricci, F


    We study the gravitational time delay in ray propagation due to rotating masses in the linear approximation of general relativity. Simple expressions are given for the gravitomagnetic time delay that occurs when rays of radiation cross a slowly rotating shell and propagate in the field of a distant rotating source. Moreover, we calculate the local gravitational time delay in the Goedel universe. The observational consequences of these results in the case of weak gravitational lensing are disc...

  6. Time Delay of CGM Sensors

    Schmelzeisen-Redeker, Günther; Schoemaker, Michael; Kirchsteiger, Harald; Freckmann, Guido; Heinemann, Lutz; del Re, Luigi


    Background: Continuous glucose monitoring (CGM) is a powerful tool to support the optimization of glucose control of patients with diabetes. However, CGM systems measure glucose in interstitial fluid but not in blood. Rapid changes in one compartment are not accompanied by similar changes in the other, but follow with some delay. Such time delays hamper detection of, for example, hypoglycemic events. Our aim is to discuss the causes and extent of time delays and approaches to compensate for these. Methods: CGM data were obtained in a clinical study with 37 patients with a prototype glucose sensor. The study was divided into 5 phases over 2 years. In all, 8 patients participated in 2 phases separated by 8 months. A total number of 108 CGM data sets including raw signals were used for data analysis and were processed by statistical methods to obtain estimates of the time delay. Results: Overall mean (SD) time delay of the raw signals with respect to blood glucose was 9.5 (3.7) min, median was 9 min (interquartile range 4 min). Analysis of time delays observed in the same patients separated by 8 months suggests a patient dependent delay. No significant correlation was observed between delay and anamnestic or anthropometric data. The use of a prediction algorithm reduced the delay by 4 minutes on average. Conclusions: Prediction algorithms should be used to provide real-time CGM readings more consistent with simultaneous measurements by SMBG. Patient specificity may play an important role in improving prediction quality. PMID:26243773

  7. Concurrent Delay in Construction Disputes

    Cavaleri, Sylvie Cécile

    period of delay can potentially be attributed to several events falling within both parties' spheres of responsibility, commonly termed concurrent delay, is rarely regulated in construction contracts in spite of its common occurrence. This book analyses both the theoretical foundations and the practical......Delay is one of the issues most frequently encountered in today’s construction industry; it causes significant economic damage to all parties involved. Construction contracts, standard and bespoke, almost invariably consider delay from a perspective of single liability. If the event causing...

  8. Delay-dependent robust H∞ control of convex polyhedral uncertain fuzzy systems


    The robust H∞ control problem for a class of uncertain Takagi-Sugeno fuzzy systems with time-varying state delays is studied. The uncertain parameters are supposed to reside in a polytope. Based on the delay-dependent Lyapunov functional method, a new delay-dependent robust H∞ fuzzy controller, which depends on the size of the delays and the derivative of the delays, is presented in term of linear matrix inequalities (LMIs). For all admissible uncertainties and delays, the controller guarantees not only the asymptotic stability of the system but also the prescribed H∞ attenuation level. In addition, the effectiveness of the proposed design method is demonstrated by a numerical example.

  9. Assessing Visual Delays using Pupil Oscillations

    Mulligan, Jeffrey B.


    Stark (1962) demonstrated vigorous pupil oscillations by illuminating the retina with a beam of light focussed to a small spot near the edge of the pupil. Small constrictions of the pupil then are sufficient to completely block the beam, amplifying the normal relationship between pupil area and retinal illuminance. In addition to this simple and elegant method, Stark also investigated more complex feedback systems using an electronic "clamping box" which provided arbitrary gain and phase delay between a measurement of pupil area and an electronically controlled light source. We have replicated Stark's results using a video-based pupillometer to control the luminance of a display monitor. Pupil oscillations were induced by imposing a linear relationship between pupil area and display luminance, with a variable delay. Slopes of the period-vs-delay function for 3 subjects are close to the predicted value of 2 (1.96-2.39), and the implied delays range from 254 to 376 508 to 652 milliseconds. Our setup allows us to extend Stark's work by investigating a broader class of stimuli.

  10. Bifurcation and nonlinear analysis of a time-delayed thermoacoustic system

    Yang, Xiaochuan; Turan, Ali; Lei, Shenghui


    In this paper, of primary concern is a time-delayed thermoacoustic system, viz. a horizontal Rijke tube. A continuation approach is employed to capture the nonlinear behaviour inherent to the system. Unlike the conventional approach by the Galerkin method, a dynamic system is naturally built up by discretizing the acoustic momentum and energy equations incorporating appropriate boundary conditions using a finite difference method. In addition, the interaction of Rijke tube velocity with oscillatory heat release is modeled using a modified form of King's law. A comparison of the numerical results with experimental data and the calculations reported reveals that the current approach can yield very good predictions. Moreover, subcritical Hopf bifurcations and fold bifurcations are captured with the evolution of dimensionless heat release coefficient, generic damping coefficient and time delay. Linear stability boundary, nonlinear stability boundary, bistable region and limit cycles are thus determined to gain an understanding of the intrinsic nonlinear behaviours.

  11. Chaos synchronization by resonance of multiple delay times

    Martin, Manuel Jimenez; D'Huys, Otti; Lauerbach, Laura; Korutcheva, Elka; Kinzel, Wolfgang


    Chaos synchronization may arise in networks of nonlinear units with delayed couplings. We study complete and sublattice synchronization generated by resonance of two large time delays with a specific ratio. As it is known for single-delay networks, the number of synchronized sublattices is determined by the greatest common divisor (GCD) of the network loop lengths. We demonstrate analytically the GCD condition in networks of iterated Bernoulli maps with multiple delay times and complement our analytic results by numerical phase diagrams, providing parameter regions showing complete and sublattice synchronization by resonance for Tent and Bernoulli maps. We compare networks with the same GCD with single and multiple delays, and we investigate the sensitivity of the correlation to a detuning between the delays in a network of coupled Stuart-Landau oscillators. Moreover, the GCD condition also allows detection of time-delay resonances, leading to high correlations in nonsynchronizable networks. Specifically, GCD-induced resonances are observed both in a chaotic asymmetric network and in doubly connected rings of delay-coupled noisy linear oscillators.

  12. On modeling the digital gate delay under process variation

    Gao Mingzhi; Ye Zuochang; Wang Yan; Yu Zhiping


    To achieve a characterization method for the gate delay library used in block based statistical static timing analysis with neither unacceptably poor accuracy nor forbiddingly high cost,we found that general-purpose gate delay models are useful as intermediaries between the circuit simulation data and the gate delay models in required forms.In this work,two gate delay models for process variation considering different driving and loading conditions are proposed.From the testing results,these two models,especially the one that combines effective dimension reduction (EDR) from statistics society with comprehensive gate delay models,offer good accuracy with low characterization cost,and they are thus competent for use in statistical timing analysis (SSTA).In addition,these two models have their own value in other SSTA techniques.

  13. Observer design for compensation of network-induced delays in integrated communication and control systems

    Luck, R.; Ray, A.


    A method for compensating the effects of network-induced delays in integrated communication and control systems (ICCS) is proposed, and a finite-dimensional time-invariant ICCS model is developed. The problem of analyzing systems with time-varying and stochastic delays is circumvented by the application of a deterministic observer. For the case of controller-to-actuator delays, the observed design must rely on an extended model which represents the delays as additional states.

  14. Magnetic bearing optical delay line

    Dool, T.C. van den; Kamphues, F.G.; Fouss, B.; Henrioulle, K.; Hogenhuis, H.


    TNO TPD, in close cooperation with Micromega-Dynamics and Dutch Space, has developed an advanced Optical Delay Line (ODL) for use in PRIMA, GENIE and other ground based interferometers. The delay line design is modular and flexible, which makes scaling for other applications a relatively easy task.

  15. #FakeNobelDelayReasons


    Tuesday’s hour-long delay of the Nobel Prize in Physics announcement was (and still is) quite the cause for speculation. But on the Twittersphere, it was simply the catalyst for some fantastic puns, so-bad-they're-good physics jokes and other shenanigans. Here are some of our favourite #FakeNobelDelayReasons.    

  16. Imitation dynamics with time delay.

    Wang, Shi-Chang; Yu, Jie-Ru; Kurokawa, Shun; Tao, Yi


    Based on the classic imitation dynamics (Hofbauer and Sigmund, 1998, Evolutionary Games and Population Dynamics, Cambridge University Press), the imitation dynamics with time delay is investigated, where the probability that an individual will imitate its opponent's own strategy is assumed to depend on the comparison between the past expected payoff of this individual's own strategy and the past expected payoff of its opponent's own strategy, i.e. there is a time delay effect. For the two-phenotype model, we show that if the system has an interior equilibrium and this interior equilibrium is stable when there is no time delay, then there must be a critical value of time delay such that the system tends to a stable periodic solution when the time delay is larger than the critical value. On the other hand, for three-phenotype (rock-scissors-paper) model, the numerical analysis shows that for the stable periodic solution induced by the time delay, the amplitude and the period will increase with the increase of the time delay. These results should help to understand the evolution of behavior based on the imitation dynamics with time delay.

  17. Calibrating for Ionospheric Phase Delays

    Macdoran, P. F.


    Technique determines ionospheric phase delay on real-time universally applicable basis in terms of electrons per meter squared by coherently modulating two L-band carrier frequencies received from two Global Positioning System satelites. Two pseudorandom number sequences cross-correlated to derive delay time.

  18. Unsignaled delay of reinforcement, relative time, and resistance to change.

    Shahan, Timothy A; Lattal, Kennon A


    Two experiments with pigeons examined the effects of unsignaled, nonresetting delays of reinforcement on responding maintained by different reinforcement rates. In Experiment 1, 3-s unsignaled delays were introduced into each component of a multiple variable-interval (VI) 15-s VI 90-s VI 540-s schedule. When considered as a proportion of the preceding immediate reinforcement baseline, responding was decreased similarly for the three multiple-schedule components in both the first six and last six sessions of exposure to the delay. In addition, the relation between response rates and reinforcement rates was altered such that both parameters of the single-response version of the matching law (i.e., k and Re) were decreased. Experiment 2 examined the effects of unsignaled delays ranging from 0.5 s to 8.0 s on responding maintained by a multiple VI 20-s VI 120-s schedule of reinforcement. Response rates in both components increased with brief unsignaled delays and decreased with longer delays. As in Experiment 1, response rates as a proportion of baseline were affected similarly for the two components in both the first six and last six sessions of exposure to the delay. Unlike delays imposed between two stimulus events, the effects of delays between responses and reinforcers do not appear to be attenuated when the average time between reinforcers is longer. In addition, the disruptions produced by unsignaled delays appear to be inconsistent with the general finding that responding maintained by higher rates of reinforcement is less resistant to change.

  19. Time-delay damping theory



    In this paper, existing damping theories are briefly reviewed. On the basis of the existing damping theories, a new kind of damping theory, i.e., the time-delay damping theory, is developed. In the time-delay damping theory, the damping force is considered to be directly proportional to the increment of displacement. The response analysis of an SDOF time-delay damping system is carried out, and the methods for obtaining the solution for a time-delay damping system in the time domain as well as the frequency domain are given. The comparison between results from different damping theories shows that the time-delay damping theory is both reasonable and convenient.

  20. Asynchronous Bounded Expected Delay Networks

    Bakhshi, Rena; Fokkink, Wan; Pang, Jun


    The commonly used asynchronous bounded delay (ABD) network models assume a fixed bound on message delay. We propose a probabilistic network model, called asynchronous bounded expected delay (ABE) model. Instead of a strict bound, the ABE model requires only a bound on the expected message delay. While the conditions of ABD networks restrict the set of possible executions, in ABE networks all asynchronous executions are possible, but executions with extremely long delays are less probable. In contrast to ABD networks, ABE networks cannot be synchronised efficiently. At the example of an election algorithm, we show that the minimal assumptions of ABE networks are sufficient for the development of efficient algorithms. For anonymous, unidirectional ABE rings of known size N we devise a probabilistic leader election algorithm having average message and time complexity O(N).

  1. Flight delay performance at Hartsfield-Jackson Atlanta International Airport

    Grigoriy Yablonsky


    Full Text Available Purpose: The main objective of this paper is to determine the annual cyclical flight delays at Hartsfield-Jackson Atlanta International Airport. Then using other data such as annual precipitation, passenger and aircraft traffic volumes and other factors, we attempted to correlate these factors with overall delays. These data could assist airport management in predicting periods of flight delay.Design/methodology/approach: Data were taken and analyzed from the data base “Research and Innovation Technology Administration” (RITA for the years 2005-2011 for Hartsfield-Jackson Atlanta International Airport. The data included 2.8 million flights originating and departing from this airport. Data were also gathered from the National Oceanic and Atmospheric Administration (NOAA showing precipitation. Additional data were gathered from the FAA regarding delay causes, number and types of delays and changes to the infrastructure of ATL airportFindings: There is a repeatable annual pattern of delays at ATL that can be modeled using delay data from the Bureau of Transportation Statistics. This pattern appears to be caused primarily by the frequency and amount of precipitation that falls at ATL and by the amount of flights that arrive and depart at ATL.Originality/value: This information could assist airport operations personnel, FAA air traffic controllers and airlines in anticipating and mitigating delays at specific times of the year.

  2. Group delay functions and its applications in speech technology

    Hema A Murthy; B Yegnanarayana


    Traditionally, the information in speech signals is represented in terms of features derived from short-time Fourier analysis. In this analysis the features extracted from the magnitude of the Fourier transform (FT) are considered, ignoring the phase component. Although the significance of the FT phase was highlighted in several studies over the recent three decades, the features of the FT phase were not exploited fully due to difficulty in computing the phase and also in processing the phase function. The information in the short-time FT phase function can be extracted by processing the derivative of the FT phase, i.e., the group delay function. In this paper, the properties of the group delay functions are reviewed, highlighting the importance of the FT phase for representing information in the speech signal. Methods to process the group delay function are discussed to capture the characteristics of the vocal-tract system in the form of formants or through a modified group delay function. Applications of group delay functions for speech processing are discussed in some detail. They include segmentation of speech into syllable boundaries, exploiting the additive and high resolution properties of the group delay functions. The effectiveness of segmentation of speech, and the features derived from the modified group delay are demonstrated in applications such as language identification, speech recognition and speaker recognition. The paper thus demonstrates the need to exploit the potential of the group delay functions for development of speech systems.

  3. Delayed feedback control of unstable steady states in fractional-order chaotic systems

    Gjurchinovski, Aleksandar; Urumov, Viktor


    We study the possibility to stabilize unstable steady states in chaotic fractional-order dynamical systems by the time-delayed feedback method with both constant and time-varying delays. By performing a linear stability analysis in the constant delay case, we establish the parameter ranges for successful stabilization of unstable equilibria in the plane parametrizad by the feedback gain and the time delay. An insight into the control mechanism is gained by analyzing the characteristic equation of the controlled system, showing that the control scheme fails to control unstable equilibria having an odd number of positive real eigenvalues. It is shown numerically that delayed feedback control with a variable time-delay significantly enlarges the stability region of the steady states in comparison to the classical time-delayed feedback scheme with a constant delay.

  4. Energy management - The delayed flap approach

    Bull, J. S.


    Flight test evaluation of a Delayed Flap approach procedure intended to provide reductions in noise and fuel consumption is underway using the NASA CV-990 test aircraft. Approach is initiated at a high airspeed (240 kt) and in a drag configuration that allows for low thrust. The aircraft is flown along the conventional ILS glide slope. A Fast/Slow message display signals the pilot when to extend approach flaps, landing gear, and land flaps. Implementation of the procedure in commercial service may require the addition of a DME navigation aid co-located with the ILS glide slope transmitter. The Delayed Flap approach saves 250 lb of fuel over the Reduced Flap approach, with a 95 EPNdB noise contour only 43% as large.

  5. Dynamical behaviors in time-delay systems with delayed feedback and digitized coupling

    Mitra, Chiranjit; Ambika, G.; Banerjee, Soumitro


    We consider a network of delay dynamical systems connected in a ring via unidirectional positive feedback with constant delay in coupling. For the specific case of Mackey-Glass systems on the ring topology, we capture the phenomena of amplitude death, isochronous synchronization and phase-flip bifurcation as the relevant parameters are tuned. Using linear stability analysis and master stability function approach, we predict the region of amplitude death and synchronized states respectively in the parameter space and study the nature of transitions between the different states. For a large number of systems in the same dynamical configuration, we observe splay states, mixed splay states and phase locked clusters. We extend the study to the case of digitized coupling and observe that these emergent states still persist. However, the sampling and quantization reduce the regions of amplitude death and induce phase-flip bifurcation.

  6. Factors associated with patient and provider delays for tuberculosis diagnosis and treatment in Asia: a systematic review and meta-analysis.

    Jing Cai

    Full Text Available Delays in tuberculosis (TB diagnosis and treatment is a major barrier to effective management of the disease. Determining the factors associated with patient and provider delay of TB diagnosis and treatment in Asia may contribute to TB prevention and control.We searched the PubMed, EMBASE and Web of Science for studies that assessed factors associated with delays in care-seeking, diagnosis, or at the beginning of treatment, which were published from January 1992 to September 2014. Two reviewers independently identified studies that were related to our meta-analysis and extracted data from each study. Independent variables were categorized in separate tables for patient and provider delays.Among 45 eligible studies, 40 studies assessed patient delay whereas 30 assessed provider delay. Cross-sectional surveys were used in all but two articles, which included 17 countries and regions. Socio-demographic characteristics, TB-related symptoms and medical examination, and conditions of seeking medical care in TB patients were frequently reported. Male patients and long travel time/distance to the first healthcare provider led to both shorter patient delays [odds ratio (OR (95% confidence intervals, CI = 0.85 (0.78, 0.92; 1.39 (1.08, 1.78] and shorter provider delays [OR (95%CI = 0.96 (0.93, 1.00; 1.68 (1.12, 2.51]. Unemployment, low income, hemoptysis, and positive sputum smears were consistently associated with patient delay [ORs (95%CI = 1.18 (1.07, 1.30, 1.23 (1.02, 1.49, 0.64 (0.40, 1.00, 1.77 (1.07, 2.94, respectively]. Additionally, consultation at a public hospital was associated with provider delay [OR (95%CI = 0.43 (0.20, 0.91].We propose that the major opportunities to reduce delays involve enabling socio-demographic factors and medical conditions. Male, unemployed, rural residence, low income, hemoptysis, positive sputum smear, and long travel time/distance significantly correlated with patient delay. Male, long travel time/distance and

  7. Delayed Bilateral Teleoperation of Wheeled Robots including a Command Metric


    This paper proposes a control scheme applied to the delayed bilateral teleoperation of wheeled robots with force feedback, considering the performance of the operator`s command execution. In addition, the stability of the system is analyzed taking into account the dynamic model of the master as well as the remote mobile robot under asymmetric and time-varying delays of the communication channel. Besides, the performance of the teleoperation system, where a human operator drives a 3D simulator...

  8. Time Delay in Molecular Photoionization

    Hockett, P; Villeneuve, D M; Corkum, P B


    Time-delays in the photoionization of molecules are investigated. As compared to atomic ionization, the time-delays expected from molecular ionization present a much richer phenomenon, with a strong spatial dependence due to the anisotropic nature of the molecular scattering potential. We investigate this from a scattering theory perspective, and make use of molecular photoionization calculations to examine this effect in representative homonuclear and hetronuclear diatomic molecules, nitrogen and carbon monoxide. We present energy and angle-resolved maps of the Wigner delay time for single-photon valence ionization, and discuss the possibilities for experimental measurements.

  9. Delay discounting and frontostriatal fiber tracts: a combined DTI and MTR study on impulsive choices in healthy young adults.

    Peper, Jiska S; Mandl, René C W; Braams, Barbara R; de Water, Erik; Heijboer, Annemieke C; Koolschijn, P Cédric M P; Crone, Eveline A


    Delay discounting, a measure of impulsive choice, has been associated with decreased control of the prefrontal cortex over striatum responses. The anatomical connectivity between both brain regions in delaying gratification remains unknown. Here, we investigate whether the quality of frontostriatal (FS) white matter tracts can predict individual differences in delay-discounting behavior. We use tract-based diffusion tensor imaging and magnetization transfer imaging to measure the microstructural properties of FS fiber tracts in 40 healthy young adults (from 18 to 25 years). We additionally explored whether internal sex hormone levels affect the integrity of FS tracts, based on the hypothesis that sex hormones modulate axonal density within prefrontal dopaminergic circuits. We calculated fractional anisotropy (FA), mean diffusivity (MD), longitudinal diffusivity, radial diffusivity (RD), and magnetization transfer ratio (MTR), a putative measure of myelination, for the FS tract. Results showed that lower integrity within the FS tract (higher MD and RD and lower FA), predicts faster discounting in both sexes. MTR was unrelated to delay-discounting performance. In addition, testosterone levels in males were associated with a lower integrity (higher RD) within the FS tract. Our study provides support for the hypothesis that enhanced structural integrity of white matter fiber bundles between prefrontal and striatal brain areas is associated with better impulse control.

  10. 具有时滞和自食的阶段结构的合作系统的周期解的研究%The study of Periodic Solution a Nonautonomous Stage-Structured System With Time Delay and Cannibalism Two Kinds of Additive Maps on Operator Algebras

    李秋英; 贾建文


    In this paper, we consider a cooperative model,which has a discrete delay, stage structure and cannibalism. By using the continuation theorem of coincidence degree theory, a sufficient condition is obtained for the existence of a positive periodic solution of this system.%本文讨论一类具有时滞、阶段结构及自食的非自治合作系统的动力学行为,利用重合度理论中的的连续性定理,得到系统正周期解存在的充分条件.

  11. Fundamentals of Delayed Coking Joint Industry Project

    Michael Volk; Keith Wisecarver


    Delayed coking evolved steadily over the early to mid 1900s to enable refiners to convert high boiling, residual petroleum fractions to light products such as gasoline. Pound for pound, coking is the most energy intensive of any operation in a modern refinery. Large amounts of energy are required to heat the thick, poor-quality petroleum residuum to the 900 to 950 degrees F required to crack the heavy hydrocarbon molecules into lighter, more valuable products. One common misconception of delayed coking is that the product coke is a disadvantage. Although coke is a low valued (near zero economic value) byproduct, compared to transportation fuels, there is a significant worldwide trade and demand for coke as it is an economical fuel. Coke production has increased steadily over the last ten years, with further increases forecast for the foreseeable future. Current domestic production is near 111,000 tons per day. A major driving force behind this increase is the steady decline in crude quality available to refiners. Crude slates are expected to grow heavier with higher sulfur contents while environmental restrictions are expected to significantly reduce the demand for high-sulfur residual fuel oil. Light sweet crudes will continue to be available and in even greater demand than they are today. Refiners will be faced with the choice of purchasing light sweet crudes at a premium price, or adding bottom of the barrel upgrading capability, through additional new investments, to reduce the production of high-sulfur residual fuel oil and increase the production of low-sulfur distillate fuels. A second disadvantage is that liquid products from cokers frequently are unstable, i.e., they rapidly form gum and sediments. Because of intermediate investment and operating costs, delayed coking has increased in popularity among refiners worldwide. Based on the 2000 Worldwide Refining Survey published in the Oil and Gas, the delayed coking capacity for 101 refineries around the world

  12. Transient cooling during early reperfusion attenuates delayed edema and infarct progression in the Spontaneously Hypertensive Rat. Distribution and time course of regional brain temperature change in a model of postischemic hypothermic protection.

    Kurasako, Toshiaki; Zhao, Liang; Pulsinelli, William A; Nowak, Thaddeus S


    The temperature threshold for protection by brief postischemic cooling was evaluated in a model of transient focal ischemia in the Spontaneously Hypertensive Rat, using an array of epidural probes to monitor regional brain temperatures. Rats were subjected to 90 mins tandem occlusion of the right middle cerebral artery (MCA) and common carotid artery. Systemic cooling to 32 degrees C was initiated 5 mins before recirculation, with simultaneous brain cooling to temperatures ranging from 28 degrees C to 32 degrees C within the MCA territory by means of a temperature-controlled saline drip. Rewarming was initiated at 2 h recirculation and was complete within 30 mins. Tissue damage and edema volume showed clear temperature-dependent reductions when evaluated at 3 days survival, with no protection evident in the group at 32 degrees C but progressive effects on both parameters after deeper cooling. A particularly striking effect was the essentially complete elimination of edema progression between 1 and 3 days. Temperature at distal sites within the MCA territory better predicted reductions in lesion volume, indicating that protection required effective cooling of the penumbral regions destined to be spared. These results show that even brief cooling can be highly protective when initiated at the time of recirculation after focal ischemia, but indicate a substantially lower temperature threshold for hypothermic protection than has been reported for other strains, occlusion methods, and cooling durations.

  13. Delays and networked control systems

    Hetel, Laurentiu; Daafouz, Jamal; Johansson, Karl


    This edited monograph includes state-of-the-art contributions on continuous time dynamical networks with delays. The book is divided into four parts. The first part presents tools and methods for the analysis of time-delay systems with a particular attention on control problems of large scale or infinite-dimensional systems with delays. The second part of the book is dedicated to the use of time-delay models for the analysis and design of Networked Control Systems. The third part of the book focuses on the analysis and design of systems with asynchronous sampling intervals which occur in Networked Control Systems. The last part of the book exposes several contributions dealing with the design of cooperative control and observation laws for networked control systems. The target audience primarily comprises researchers and experts in the field of control theory, but the book may also be beneficial for graduate students. .

  14. Leibniz Dynamics with Time Delay

    Albu, I. D.; Opris, D.


    In this paper we show that several dynamical systems with time delay can be described as vector fields associated to smooth functions via a bracket of Leibniz structure. Some examples illustrate the theoretical considerations.

  15. Language Delays in Toddlers: Information for Parents

    ... Stages Listen Español Text Size Email Print Share Language Delays in Toddlers: Information for Parents Page Content ... situation or repeats scripts from TV Delays in language Delays in language are the most common types ...

  16. Time Delay in Molecular Photoionization

    Hockett, P.; Frumker, E.; Villeneuve, D M; Corkum, P. B.


    Time-delays in the photoionization of molecules are investigated. As compared to atomic ionization, the time-delays expected from molecular ionization present a much richer phenomenon, with a strong spatial dependence due to the anisotropic nature of the molecular scattering potential. We investigate this from a scattering theory perspective, and make use of molecular photoionization calculations to examine this effect in representative homonuclear and hetronuclear diatomic molecules, nitroge...

  17. Measuring information-transfer delays.

    Michael Wibral

    Full Text Available In complex networks such as gene networks, traffic systems or brain circuits it is important to understand how long it takes for the different parts of the network to effectively influence one another. In the brain, for example, axonal delays between brain areas can amount to several tens of milliseconds, adding an intrinsic component to any timing-based processing of information. Inferring neural interaction delays is thus needed to interpret the information transfer revealed by any analysis of directed interactions across brain structures. However, a robust estimation of interaction delays from neural activity faces several challenges if modeling assumptions on interaction mechanisms are wrong or cannot be made. Here, we propose a robust estimator for neuronal interaction delays rooted in an information-theoretic framework, which allows a model-free exploration of interactions. In particular, we extend transfer entropy to account for delayed source-target interactions, while crucially retaining the conditioning on the embedded target state at the immediately previous time step. We prove that this particular extension is indeed guaranteed to identify interaction delays between two coupled systems and is the only relevant option in keeping with Wiener's principle of causality. We demonstrate the performance of our approach in detecting interaction delays on finite data by numerical simulations of stochastic and deterministic processes, as well as on local field potential recordings. We also show the ability of the extended transfer entropy to detect the presence of multiple delays, as well as feedback loops. While evaluated on neuroscience data, we expect the estimator to be useful in other fields dealing with network dynamics.

  18. Basin stability in delayed dynamics

    Leng, Siyang; Lin, Wei; Kurths, Jürgen


    Basin stability (BS) is a universal concept for complex systems studies, which focuses on the volume of the basin of attraction instead of the traditional linearization-based approach. It has a lot of applications in real-world systems especially in dynamical systems with a phenomenon of multi-stability, which is even more ubiquitous in delayed dynamics such as the firing neurons, the climatological processes, and the power grids. Due to the infinite dimensional property of the space for the initial values, how to properly define the basin’s volume for delayed dynamics remains a fundamental problem. We propose here a technique which projects the infinite dimensional initial state space to a finite-dimensional Euclidean space by expanding the initial function along with different orthogonal or nonorthogonal basis. A generalized concept of basin’s volume in delayed dynamics and a highly practicable calculating algorithm with a cross-validation procedure are provided to numerically estimate the basin of attraction in delayed dynamics. We show potential applicabilities of this approach by applying it to study several representative systems of biological or/and physical significance, including the delayed Hopfield neuronal model with multistability and delayed complex networks with synchronization dynamics.

  19. Reaction diffusion equation with spatio-temporal delay

    Zhao, Zhihong; Rong, Erhua


    We investigate reaction-diffusion equation with spatio-temporal delays, the global existence, uniqueness and asymptotic behavior of solutions for which in relation to constant steady-state solution, included in the region of attraction of a stable steady solution. It is shown that if the delay reaction function satisfies some conditions and the system possesses a pair of upper and lower solutions then there exists a unique global solution. In terms of the maximal and minimal constant solutions of the corresponding steady-state problem, we get the asymptotic stability of reaction-diffusion equation with spatio-temporal delay. Applying this theory to Lotka-Volterra model with spatio-temporal delay, we get the global solution asymptotically tend to the steady-state problem's steady-state solution.

  20. Geometric representation for numerical stability region of linear multistep methods


    Studies the numerical stability region of linear multistep(LM) methods applied to linear test equation of the formy′(t) = ay(t) + by( t - 1), t > 0, y( t ) = g( t ) - 1 ≤ t ≤ 0, a,b ∈ R, proves through delaydependent stability analysis that the intersection of stability regions of the equation and the method is not empty, in addition to approaches to the boundary of the delay differential equation(DDEs) in the limiting case of stepsize boundary of the stability region of linear multistep methods.

  1. 术中非手术区迟发性颅内血肿致急性脑膨出的高危因素及抢救体会40例%The high risk factors and emergency treatments to the patients with in-traoperative acute encephalocele caused by delayed intracranial hematomas at non operating region:An investigate of 40 cases

    赵刚; 刘帅; 李俊; 王宇; 孙继程; 张义; 王铂


    目的:探讨术中非手术区迟发性颅内血肿致急性脑膨出患者的临床高危因素及抢救经验。方法对2000年1月~2013年12月40例术中非手术区迟发性颅内血肿致急性脑膨出患者的临床资料进行回顾性分析,总结其高危因素及抢救经验。结果对冲伤22例。术前合并广泛脑挫裂伤14例,合并颅骨骨折16例,合并颅内小血肿(<15 mL)10例。致急性脑膨出的颅内血肿中对侧32例,其中硬膜外血肿24例。再手术32例,存活16例,总死亡率60%。结论术中非手术区迟发性颅内血肿致急性脑膨出高危因素为广泛脑挫裂伤、对侧颅骨骨折、非手术区的颅内小血肿。掌握其临床高危因素,有足够的预见性,充分的术前准备,正确的术中处理,术后科学系统的综合治疗才能最大限度地挽救患者生命。%Objective To investigate the high risk factors and emergency treatments to the patients with intraoperative acute encephalocele caused by delayed intracranial hematomas at non operating region. Methods The clinical data of 40 patients with intraoperative acute encephalocele caused by delayed intracranial hematomas at non operating region from January 2000 to December 2013 were analyzed retrospectively. Summarized the high risk factors and emergency treatments in this case. Results The 22 cases with contrecoup injury. 14 cases with extensive contusion of brain,16 cases with skull fracture and 10 cases with small intracranial hematoma (Volume <15mL).The delayed intracranial hematomas to the acute encephalocele include,32 cases at the offside. And 24 cases with epidural hematoma. 32 cases had to undergo reoperation, survived 16 cases. The total death rate was 60%. Conclusion The high risk factors are ex-tensive contusion of brain, offside skull fracture and the delayed intracranial hematomas at non operating region. Under-standing Its high risk factors in clinical, with much more foreseeability, and

  2. Various Forms of Project Delay in the Construction Industry

    Nurbasirah Mohamed Alias


    Full Text Available Project delay can be defined as an incident that causes extended time in order to complete all or part of a particular project successfully. In other words, delay is the time overrun, either ahead of the date for project completion specified by the contract or further than the extensive contract period where an addition of time has been granted. It should be pointed out that the project delay in the construction industry is a universal or large-scale observable fact affecting not only the construction industry but the overall economy of countries too. As far as world construction industry is concerned, project delays are common problems in the construction industries; particularly most common is in the housing development industries. This paper will present different types of project delay that took place around the world. Project delay involves diverse complicated issues all of which are continuously of crucial importance to the parties to the construction contract. These issues concern right to convalesce costs of the project delay or the need to lengthen the project with the considerable right to recovery costs for adjustments to the contract schedules.

  3. On Delay-independent Stability Criteria for Linear Time-delay Systems

    Ai-Guo Wu; Guang-Ren Duan


    Several LMI representations for delay-independence stability are proposed by applying Projection Lemma and the socalled "Small Scalar Method". These criteria realize the elimination of the products coupling the system matrices and Lyapunov matrices by introducing some additional matrices. When they are applied to robust stability analysis for polytopic uncertain systems,the vertex-dependent Lyapunov functions are allowed, so less conservative results can be obtained. A numerical example is employed to illustrate the effect of these proposed criteria.

  4. Effects of Delayed Second Cochlear Implant

    XIA Rui-ming; WU Xi-hong; JANG Zi-gang; JING Yuan-yuan; LIN Yun-juan; YU Li-sheng


    Objective Since Helms' successful bilateral cochlear implantation with good results in 1996, there have been increasing number of reports on bilateral cochlear implantation. Most second device have been implantated within one year after the first. Considering effects of long time auditory deprivation, it is not clear whether a delayed second cochlear implant serves to add additional benefits and how it may interact with central nervous system plasticity. Methods Three cases who received delayed second cochlear implants at People's Hospital of Peking University from 2002 to 2005 were reviewed. The interval between the first and second implants was longer than 2 years in all three patients. Sound perception, and unilateral/bilateral speech discrimination in quiet and noise were evaluated. In addition, GAP detection test was conducted in one patient. Results In one case,having both implants on provided improved performance compared to using only one implant both in quiet and noise. Presumably due to visual interference from lip-reading or short interval between second implant and testing,one patient showed no improvement from using the second implant either in quiet or noise, while the last case demonstrated additional benefits from the second implant only in quiet. In all three patients, performance in recognizing the four tones in Mandarin was superior over word recognition. Conclusions Considerable plasticity in the cerebral auditory center is preserved, despite long acoustic deprivation in some children who have received unilateral cochlear implant. Delayed second implants can result in significant improvements in some of these children. Visual interference from lip-reading may be an obstacle during retraining. The better recognition of tones in the Mandarin language may represent a different sound discrimination mechanism in the auditory system,although it may also be related to the signal processing mechanisms of the implant used (MED-EL COMBI 40+).

  5. Earth system commitments due to delayed mitigation

    Pfister, Patrik L.; Stocker, Thomas F.


    As long as global CO2 emissions continue to increase annually, long-term committed Earth system changes grow much faster than current observations. A novel metric linking this future growth to policy decisions today is the mitigation delay sensitivity (MDS), but MDS estimates for Earth system variables other than peak temperature (ΔT max) are missing. Using an Earth System Model of Intermediate Complexity, we show that the current emission increase rate causes a ΔT max increase roughly 3-7.5 times as fast as observed warming, and a millenial steric sea level rise (SSLR) 7-25 times as fast as observed SSLR, depending on the achievable rate of emission reductions after the peak of emissions. These ranges are only slightly affected by the uncertainty range in equilibrium climate sensitivity, which is included in the above values. The extent of ocean acidification at the end of the century is also strongly dependent on the starting time and rate of emission reductions. The preservable surface ocean area with sufficient aragonite supersaturation for coral reef growth is diminished globally at an MDS of roughly 25%-80% per decade. A near-complete loss of this area becomes unavoidable if mitigation is delayed for a few years to decades. Also with respect to aragonite, 12%-18% of the Southern Ocean surface become undersaturated per decade, if emission reductions are delayed beyond 2015-2040. We conclude that the consequences of delaying global emission reductions are much better captured if the MDS of relevant Earth system variables is communicated in addition to current trends and total projected future changes.

  6. Optimal state estimation over communication channels with random delays

    Mahmoud, Magdi S.


    This paper is concerned with the optimal estimation of linear systems over unreliable communication channels with random delays. The measurements are delivered without time stamp, and the probabilities of time delays are assumed to be known. Since the estimation is time-driven, the actual time delays are converted into virtual time delays among the formulation. The receiver of estimation node stores the sum of arrived measurements between two adjacent processing time instants and also counts the number of arrived measurements. The original linear system is modeled as an extended system with uncertain observation to capture the feature of communication, then the optimal estimation algorithm of systems with uncertain observations is proposed. Additionally, a numerical simulation is presented to show the performance of this work. © 2013 The Franklin Institute.

  7. On delay-dependent robust stability for uncertain neutral systems

    He Yong; Wu Min


    The problem of delay-dependent criteria for the robust stability of neutral systems with time-varying structured uncertainties and identi-eal neutral-delay and discrete-delay is concerned. A criterion for nominal systems is presented by taking the relationship between the terms in the Leibniz-Newton formula into account, which is described by some freeweighting matrices. In addition, this criterion is extended to robust stability of the systems with time-varying structured uncertainties. All of the criteria are based on linear matrix inequality such that it is easy to calculate the upper bound of the time-delay and the free-weighting matrices. Numerical examples illustrate the effectiveness and the improvement over the existing results.

  8. Delayed Gastric Emptying after Living Donor Hepatectomy for Liver Transplantation

    Hanjay Wang


    Full Text Available Delayed gastric emptying is a significant postoperative complication of living donor hepatectomy for liver transplantation and may require endoscopic or surgical intervention in severe cases. Although the mechanism of posthepatectomy delayed gastric emptying remains unknown, vagal nerve injury during intraoperative dissection and adhesion formation postoperatively between the stomach and cut liver surface are possible explanations. Here, we present the first reported case of delayed gastric emptying following fully laparoscopic hepatectomy for living donor liver transplantation. Additionally, we also present a case in which symptoms developed after open right hepatectomy, but for which dissection for left hepatectomy was first performed. Through our experience and these two specific cases, we favor a neurovascular etiology for delayed gastric emptying after hepatectomy.

  9. Targeted resequencing of the pericentromere of chromosome 2 linked to constitutional delay of growth and puberty.

    Diana L Cousminer

    Full Text Available Constitutional delay of growth and puberty (CDGP is the most common cause of pubertal delay. CDGP is defined as the proportion of the normal population who experience pubertal onset at least 2 SD later than the population mean, representing 2.3% of all adolescents. While adolescents with CDGP spontaneously enter puberty, they are at risk for short stature, decreased bone mineral density, and psychosocial problems. Genetic factors contribute heavily to the timing of puberty, but the vast majority of CDGP cases remain biologically unexplained, and there is no definitive test to distinguish CDGP from pathological absence of puberty during adolescence. Recently, we published a study identifying significant linkage between a locus at the pericentromeric region of chromosome 2 (chr 2 and CDGP in Finnish families. To investigate this region for causal variation, we sequenced chr 2 between the genomic coordinates of 79-124 Mb (genome build GRCh37 in the proband and affected parent of the 13 families contributing most to this linkage signal. One gene, DNAH6, harbored 6 protein-altering low-frequency variants (< 6% in the Finnish population in 10 of the CDGP probands. We sequenced an additional 135 unrelated Finnish CDGP subjects and utilized the unique Sequencing Initiative Suomi (SISu population reference exome set to show that while 5 of these variants were present in the CDGP set, they were also present in the Finnish population at similar frequencies. Additional variants in the targeted region could not be prioritized for follow-up, possibly due to gaps in sequencing coverage or lack of functional knowledge of non-genic genomic regions. Thus, despite having a well-characterized sample collection from a genetically homogeneous population with a large population-based reference sequence dataset, we were unable to pinpoint variation in the linked region predisposing delayed puberty. This study highlights the difficulties of detecting genetic variants

  10. Dynamic Server Allocation over Time Varying Channels with Switchover Delay

    Celik, Güner D; Modiano, Eytan


    We consider a dynamic server allocation problem over parallel queues with randomly varying connectivity and server switchover delay between the queues. At each time slot the server decides either to stay with the current queue or switch to another queue based on the current connectivity and the queue length information. Switchover delay occurs in many telecommunications applications and is a new modeling component of this problem that has not been previously addressed. We show that the simultaneous presence of randomly varying connectivity and switchover delay changes the system stability region and the structure of optimal policies. In the first part of the paper, we consider a system of two parallel queues, and develop a novel approach to explicitly characterize the stability region of the system using state-action frequencies which are stationary solutions to a Markov Decision Process (MDP) formulation. We then develop a frame-based dynamic control (FBDC) policy, based on the state-action frequencies, and ...

  11. Impact of the initial tropospheric zenith path delay on precise point positioning convergence during active conditions

    Kalita, J. Z.; Rzepecka, Z.


    Tropospheric delay is one of the key factors that influence the convergence time of the precise point positioning (PPP) method. Current models do not allow for the fixing of the zenith path delay tropospheric parameter, leaving the difference between nominal and final value to the estimation process. Here, we present an analysis of several PPP result-sets using the tropospheric parameter’s nominal value adopted from models: VMF1, GPT2w, MOPS, and ZERO-WET. The last variant assumes a zero value for the initial wet part of the zenith delay. The PPP results are subtracted from a solution based on the final tropospheric product from the International GNSS Service (IGS). Several days exhibiting the most active tropospheric conditions were selected for each of the 7 stations located in the mid-latitude Central European region. During the active days, application of the VMF1 model increases the resulting height component’s quality by about 33–36% when compared to the GPT2w and MOPS. The respective improvement in VMF1 latitude and longitude components is 27% and 15%. The average relative deterioration in the result standard deviations between active and calm tropospheric conditions reaches about 20–30% of the former. We discuss the impact of the initial tropospheric parameter’s variance and bias on positioning. In addition, we compare the results with those of other studies over the impact of active tropospheric conditions on the PPP method.

  12. 49 CFR 236.563 - Delay time.


    ... 49 Transportation 4 2010-10-01 2010-10-01 false Delay time. 236.563 Section 236.563 Transportation... Cab Signal Systems Rules and Instructions; Locomotives § 236.563 Delay time. Delay time of automatic... requirements of § 236.24 shall take into consideration the delay time....

  13. Time-domain nature of group delay

    王建武; 冯正和


    The characteristic of group delay is analyzed based on an electronic circuit, and its time-domain nature is studied with time-domain simulation and experiment. The time-domain simulations and experimental results show that group delay is the delay of the energy center of the amplitude-modulated pulse, rather than the propagation delay of the electromagnetic field. As group velocity originates from the definition of group delay and group delay is different from the propagation delay, the superluminality or negativity of group velocity does not mean the superluminal or negative propagation of the electromagnetic field.

  14. Delay equations and radiation damping

    Chicone, C.; Kopeikin, S. M.; Mashhoon, B.; Retzloff, D. G.


    Starting from delay equations that model field retardation effects, we study the origin of runaway modes that appear in the solutions of the classical equations of motion involving the radiation reaction force. When retardation effects are small, we argue that the physically significant solutions belong to the so-called slow manifold of the system and we identify this invariant manifold with the attractor in the state space of the delay equation. We demonstrate via an example that when retardation effects are no longer small, the motion could exhibit bifurcation phenomena that are not contained in the local equations of motion.

  15. Factors Influencing Pre-hospital Patient Delay in Patients with Acute Myocardial Infarction

    La Xie; Su-Fang Huang∗; You-Zhen Hu


    Acute myocardial infarction ( AMI) is a dangerous disease with a high mortality rate. For AMI patients, the outcome of the patients depends on time to beginning of effective treatment in addition to other factors such as severity of disease and involved vessels etc. The key is whether reperfusion therapy is started early enough after the onset of symptoms, and the benefit of reperfu-sion therapy depends on the time, too. The delay of AMI treatment is divided into pre-hospital de-lay and in-hospital delay. In-hospital delay, Door-to-Balloon Time, has been well controlled. Pre-hospital delay, accounting for 75% of the total delay time, is the most important factor affect-ing AMI treatment. Patient delay ( PD) time for AMI patients is summarised in this study.

  16. Data Mining for Understanding and Improving Decision-making Affecting Ground Delay Programs

    Kulkarni, Deepak; Wang, Yao; Sridhar, Banavar


    The continuous growth in the demand for air transportation results in an imbalance between airspace capacity and traffic demand. The airspace capacity of a region depends on the ability of the system to maintain safe separation between aircraft in the region. In addition to growing demand, the airspace capacity is severely limited by convective weather. During such conditions, traffic managers at the FAA's Air Traffic Control System Command Center (ATCSCC) and dispatchers at various Airlines' Operations Center (AOC) collaborate to mitigate the demand-capacity imbalance caused by weather. The end result is the implementation of a set of Traffic Flow Management (TFM) initiatives such as ground delay programs, reroute advisories, flow metering, and ground stops. Data Mining is the automated process of analyzing large sets of data and then extracting patterns in the data. Data mining tools are capable of predicting behaviors and future trends, allowing an organization to benefit from past experience in making knowledge-driven decisions.

  17. Time Delay Circuits: A Quality Criterion for Delay Variations versus Frequency

    Garakoui, Seyed Kasra; Klumperink, Eric A.M.; Nauta, Bram; Vliet, van Frank E.


    This paper shows that the group delay of a delay circuit does not give sufficient information to predict the delay vs. frequency. A new criterion (fϕ=0) is proposed that characterizes the delay variations over a specified frequency range. The mathematical derivation of fϕ=0 for a single delay block



    In this paper,the all-delay stability of degenerate differential systems with delay is discussed.We come up with some new criteria for evaluating the all-delay stability of degenerate differential systems with delay and degenerate neutral differential systems with delay.Also,we give an example to illustrate the main results.

  19. Deconstructing delayed posttraumatic stress disorder

    Smid, G.E.


    According to the Diagnostic and Statistical Manual of Mental Disorders, delayed posttraumatic stress disorder (PTSD) must be diagnosed in individuals fulfilling criteria for PTSD if the onset of symptoms is at least six months after the trauma. The purpose of this thesis was to establish the prevale

  20. Advanced optical delay line demonstrator

    Dool, T.C. van den; Kamphues, F.G.; Fouss, B.; Henrioulle, K.; Hogenhuis, H.


    TNO TPD, in cooperation with Micromega-Dynamics and Dutch Space, has designed an advanced Optical Delay Line (ODL) for use in future ground based and space interferometry missions. The work is performed under NIVR contract in preparation for GENIE and DARWIN. Using the ESO PRIMA DDL requirements as

  1. Livermore blasted for project delay


    In a 12 page report issued last week, a review committee set up by the University of California has concluded that mismanagement and poor planning are to blame for significant cost overruns and delays in the construction of NIF, the worlds largest laser (1 page).

  2. Diagnostic Delay in Rheumatoid Arthritis

    Mølbaek, Karen; Hørslev-Petersen, Kim; Primdahl, Jette


    BACKGROUND: To prevent joint damage among patients with rheumatoid arthritis (RA), there is a need to minimize delays from the onset of symptoms until the initiation of appropriate therapy. The present study explored the factors that have an impact on the time it takes for Danish patients with RA...

  3. Providing Delay Guarantees in Bluetooth

    Ait Yaiz, Rachid; Heijenk, Geert; Titsworth, F.


    Bluetooth polling, also referred to as Bluetooth MAC scheduling or intra-piconet scheduling, is the mechanism that schedules the traffic between the participants in a Bluetooth network. Hence, this mechanism is highly determining with respect to the delay packets experience in a Bluetooth network. I

  4. Noise-induced decline and propagation of population in the delayed Malthus-Verhulst model

    Cai, Jianchun; Mei, Dongcheng


    The effects of multiplicative and additive colored noises on decline and propagation processes of population in the delayed stochastic Malthus-Verhulst model are investigated by numerically computing and stochastically simulating. From the biological point of view, our results indicate that: the increasing correlation time of multiplicative noise strengthens the stability of population, and the correlation time of additive noise does not affect it. The increasing correlation time of multiplicative noise slows down the replacement of old individuals with young ones, while the increasing correlation time of additive noise with short delay time and the optimal correlation time of additive noise with long delay time quicken it.

  5. Fundamentals of Delayed Coking Joint Industry Project

    Michael Volk Jr; Keith Wisecarver


    Delayed coking evolved steadily over the early to mid 1900s to enable refiners to convert high boiling, residual petroleum fractions to light products such as gasoline. Pound for pound, coking is the most energy intensive of any operation in a modern refinery. Large amounts of energy are required to heat the thick, poor-quality petroleum residuum to the 900 to 950 degrees F required to crack the heavy hydrocarbon molecules into lighter, more valuable products. One common misconception of delayed coking is that the product coke is a disadvantage. Although coke is a low valued (near zero economic value) byproduct, compared to transportation fuels, there is a significant worldwide trade and demand for coke as it is an economical fuel. Coke production has increased steadily over the last ten years, with further increases forecast for the foreseeable future. Current domestic production is near 111,000 tons per day. A major driving force behind this increase is the steady decline in crude quality available to refiners. Crude slates are expected to grow heavier with higher sulfur contents while environmental restrictions are expected to significantly reduce the demand for high-sulfur residual fuel oil. Light sweet crudes will continue to be available and in even greater demand than they are today. Refiners will be faced with the choice of purchasing light sweet crudes at a premium price, or adding bottom of the barrel upgrading capability, through additional new investments, to reduce the production of high-sulfur residual fuel oil and increase the production of low-sulfur distillate fuels. A second disadvantage is that liquid products from cokers frequently are unstable, i.e., they rapidly form gum and sediments. Because of intermediate investment and operating costs, delayed coking has increased in popularity among refiners worldwide. Based on the 2000 Worldwide Refining Survey published in the Oil and Gas, the delayed coking capacity for 101 refineries around the world

  6. Conical-Domain Model for Estimating GPS Ionospheric Delays

    Sparks, Lawrence; Komjathy, Attila; Mannucci, Anthony


    -latitudes under disturbed conditions, the accuracy of SBAS systems based upon the thin-shell model suffers due to the presence of complex ionospheric structure, high delay values, and large electron density gradients. Interpolation on the vertical delay grid serves as an additional source of delay error. The conical-domain model permits direct computation of the user s slant delay estimate without the intervening use of a vertical delay grid. The key is to restrict each fit of GPS measurements to a spatial domain encompassing signals from only one satellite. The conical domain model is so named because each fit involves a group of GPS receivers that all receive signals from the same GPS satellite (see figure); the receiver and satellite positions define a cone, the satellite position being the vertex. A user within a given cone evaluates the delay to the satellite directly, using (1) the IPP coordinates of the line of sight to the satellite and (2) broadcast fit parameters associated with the cone. The conical-domain model partly resembles the thin-shell model in that both models reduce an inherently four-dimensional problem to two dimensions. However, unlike the thin-shell model, the conical domain model does not involve any potentially erroneous simplifying assumptions about the structure of the ionosphere. In the conical domain model, the initially four-dimensional problem becomes truly two-dimensional in the sense that once a satellite location has been specified, any signal path emanating from a satellite can be identified by only two coordinates; for example, the IPP coordinates. As a consequence, a user s slant-delay estimate converges to the correct value in the limit that the receivers converge to the user s location (or, equivalently, in the limit that the measurement IPPs converge to the user s IPP).

  7. Additional disulfide bonds in insulin

    Vinther, Tine N; Pettersson, Ingrid; Huus, Kasper


    -chain is flexible and can adapt multiple conformations. We examined how well disulfide bond predictions algorithms could identify disulfide bonds in this region of insulin. In order to identify stable insulin analogues with additional disulfide bonds, which could be expressed, the Cβ cut-off distance had...... in comparison to analogues with additional disulfide bonds that were more difficult to predict. In contrast, addition of the fourth disulfide bond rendered all analogues resistant to fibrillation under stress conditions and all stable analogues bound to the insulin receptor with picomolar affinities. Thus...

  8. Impact of early or delayed elective resection in complicated diverticulitis

    Kai Bachmann; Geeske Krause; Tamina Rawnaq; Lena Tomkotter; Yogesh Vashist; Shanly Shahmiri; Jakob R Izbicki; Maximilian Bockhorn


    AIM: To investigate the outcomes of early and delayed elective resection after initial antibiotic treatment in patients with complicated diverticulitis.METHODS: The study, a non-randomized comparison of the two approaches, included 421 consecutive patients who underwent surgical resection for complicated sigmoid diverticulitis (Hinchey classification Ⅰ-Ⅱ) at the Department of Surgery, University Medical Center Hamburg-Eppendorf between 2004 and 2009. The operating procedure, duration of hospital and intensive care unit stay, outcome, complications and socioeconomic costs were analyzed, with comparison made between the early and delayed elective resection strategies. RESULTS: The severity of the diverticulitis and American Society of Anesthesiologists score were comparable for the two groups. Patients who underwent delayed elective resection had a shorter hospital stay and operating time, and the rate of successfully completed laparoscopic resections was higher (80% vs 75%). Eight patients who were scheduled for delayed elective resection required urgent surgery because of complications of the diverticulitis, which resulted in a high rate of morbidity. Analysis of the socioeconomic effects showed that hospitalization costs were significantly higher for delayed elective resection compared with early elective resection (9296 € ± 694 € vs 8423 € ± 968 €; P = 0.001). Delayed elective resection showed a trend toward lower complications, and the operation appeared simpler to perform than early elective resection. Nevertheless, delayed elective resection carries a risk of complications occurring during the period of 6-8 wk that could necessitate an urgent resection with its consequent high morbidity, which counterbalanced many of the advantages. CONCLUSION: Overall, early elective resection for complicated, non-perforated diverticulitis is shown to be a suitable alternative to delayed elective resection after 6-8 wk, with additional beneficial socioeconomic

  9. Delayed hippocampal damage in humans following cardiorespiratory arrest.

    Petito, C K; Feldmann, E; Pulsinelli, W A; Plum, F


    Transient ischemia in animals produces delayed cell death in vulnerable hippocampal neurons. To see if this occurs in humans, we reexamined brain slides from all patients with anoxic-ischemic encephalopathy and a well-documented cardiorespiratory arrest. Eight patients dying 18 hours or less after cardiac arrest had minimal damage in hippocampus and moderate damage in cerebral cortex and putamen. Six patients living 24 hours or more had severe damage in all four regions. The increase in damage with time postarrest was significant only in the hippocampus. Delayed hippocampal injury now documented in humans provides a target for possible therapy that can be initiated after cardiopulmonary resuscitation.

  10. Coping with persistent environmental problems: systemic delays in reducing eutrophication of the Baltic Sea

    Riku Varjopuro


    Full Text Available In this paper we focus on systemic delays in the Baltic Sea that cause the problem of eutrophication to persist. These problems are demonstrated in our study by addressing three types of delays: (1 decision delay: the time it takes for an idea or perceived need to be launched as a policy; (2 implementation delay: the time from the launch of a policy to the actual implementation; (3 ecosystem delay: the time difference between the implementation and an actual measurable effects. A policy process is one characterized by delays. It may take years from problem identification to a decision to taking action and several years further for actual implementation. Ecosystem responses to measures illustrate that feedback can keep the ecosystem in a certain state and cause a delay in ecosystem response. These delays can operate on decadal scales. Our aim in this paper is to analyze these systemic delays and especially to discuss how the critical delays can be better addressed in marine protection policies by strengthening the adaptive capacity of marine protection. We conclude that the development of monitoring systems and reflexive, participatory analysis of dynamics involved in the implementation are keys to improve understanding of the systemic delays. The improved understanding is necessary for the adaptive management of a persistent environmental problem. In addition to the state of the environment, the monitoring and analysis should be targeted also at the implementation of policies to ensure that the societies are investing in the right measures.

  11. Daffodil flower delay senescence in cut Iris flowers

    Doorn, van W.G.; Sinz, A.; Tomassen, M.M.M.


    Visible symptoms of tepal senescence in cut Iris x hollandica (cv. Blue Magic) flowers were delayed by placing one cut daffodil flower (Narcissus pseudonarcissus, cv. Carlton) in the same vase. Addition of mucilage, exuded by daffodil stems, to the vase water had the same effect as the flowering daf

  12. Delay of Vehicle Motion in Traffic Dynamics

    Bando, M; Nakanishi, K; Nakayama, A; Bando, Masako; Hasebe, Katsuya; Nakanishi, Ken; Nakayama, Akihiro


    We demonstrate that in Optimal Velocity Model (OVM) delay times of vehicles coming from the dynamical equation of motion of OVM almost explain the order of delay times observed in actual traffic flows without introducing explicit delay times. Delay times in various cases are estimated: the case of a leader vehicle and its follower, a queue of vehicles controlled by traffic lights and many-vehicle case of highway traffic flow. The remarkable result is that in most of the situation for which we can make a reasonable definition of a delay time, the obtained delay time is of order 1 second.

  13. The time delay in strong gravitational lensing with Gauss-Bonnet correction

    Man, Jingyun


    The time delay between two relativistic images in the strong gravitational lensing governed by Gauss-Bonnet gravity is studied. We derive and calculate the expression of time delay due to the Gauss-Bonnet coupling. It is shown that the time delay for two images with larger space each other is longer. We also find that the ratio of Gauss-Bonnet coefficient and the mass of gravitational source changes in the region like $\\frac{\\alpha}{M}\\in[0,2)$. The time delay is divergent with $\\frac{\\alpha}{M}\\longrightarrow 2$.

  14. Cryptococcosis-the impact of delay to diagnosis.

    Aye, C; Henderson, A; Yu, H; Norton, R


    Cryptococcosis is a mycotic disease caused by the yeast Cryptococcus sp. It is associated with significant mortality and morbidity, including long-term neurological sequelae. It is not known whether the high morbidity observed is related to a delay in diagnosis. A retrospective chart review of all cryptococcal infections that had been diagnosed in the region between 1997 and 2015 was performed. Twenty-nine cases were identified. Overall mortality rate was 10.3%, with an attributable mortality rate of 6.9%. Forty-five per cent of patients with central nervous system involvement developed long-term neurological deficits. Significant associations were noted between those with and without long-term neurological deficits and in both time from onset of symptoms to diagnosis (median of 45.5 days versus 18.5 days, respectively) and time from presentation to diagnosis (median 14.5 days versus 7 days, respectively). In addition, raised intracranial pressure (p 0.03) and female gender (p 0.02) were significantly associated with poor neurological outcomes. This highlights the importance of early diagnosis and the need to limit raised intracranial pressure to minimize long-term neurological deficits.

  15. Delay-dependent finite-time boundedness of a class of Markovian switching neural networks with time-varying delays.

    Zhong, Qishui; Cheng, Jun; Zhao, Yuqing


    In this paper, a novel method is developed for delay-dependent finite-time boundedness of a class of Markovian switching neural networks with time-varying delays. New sufficient condition for stochastic boundness of Markovian jumping neural networks is presented and proved by an newly augmented stochastic Lyapunov-Krasovskii functional and novel activation function conditions, the state trajectory remains in a bounded region of the state space over a given finite-time interval. Finally, a numerical example is given to illustrate the efficiency and less conservative of the proposed method.

  16. Stabilizing model predictive control for constrained nonlinear distributed delay systems.

    Mahboobi Esfanjani, R; Nikravesh, S K Y


    In this paper, a model predictive control scheme with guaranteed closed-loop asymptotic stability is proposed for a class of constrained nonlinear time-delay systems with discrete and distributed delays. A suitable terminal cost functional and also an appropriate terminal region are utilized to achieve asymptotic stability. To determine the terminal cost, a locally asymptotically stabilizing controller is designed and an appropriate Lyapunov-Krasoskii functional of the locally stabilized system is employed as the terminal cost. Furthermore, an invariant set for locally stabilized system which is established by using the Razumikhin Theorem is used as the terminal region. Simple conditions are derived to obtain terminal cost and terminal region in terms of Bilinear Matrix Inequalities. The method is illustrated by a numerical example.

  17. Multiple μ-stability of neural networks with unbounded time-varying delays.

    Wang, Lili; Chen, Tianping


    In this paper, we are concerned with a class of recurrent neural networks with unbounded time-varying delays. Based on the geometrical configuration of activation functions, the phase space R(n) can be divided into several Φη-type subsets. Accordingly, a new set of regions Ωη are proposed, and rigorous mathematical analysis is provided to derive the existence of equilibrium point and its local μ-stability in each Ωη. It concludes that the n-dimensional neural networks can exhibit at least 3(n) equilibrium points and 2(n) of them are μ-stable. Furthermore, due to the compatible property, a set of new conditions are presented to address the dynamics in the remaining 3(n)-2(n) subset regions. As direct applications of these results, we can get some criteria on the multiple exponential stability, multiple power stability, multiple log-stability, multiple log-log-stability and so on. In addition, the approach and results can also be extended to the neural networks with K-level nonlinear activation functions and unbounded time-varying delays, in which there can store (2K+1)(n) equilibrium points, (K+1)(n) of them are locally μ-stable. Numerical examples are given to illustrate the effectiveness of our results.

  18. Delay-sensitive and delay-insensitive deconvolution perfusion-CT: similar ischemic core and penumbra volumes if appropriate threshold selected for each

    Man, Fengyuan [Capital Medical University, Department of Radiology, Beijing Tongren Hospital, Beijing (China); University of Virginia, Department of Radiology, Neuroradiology Division, Charlottesville, VA (United States); Patrie, James T.; Xin, Wenjun [University of Virginia, Department of Public Health Sciences, Charlottesville, VA (United States); Zhu, Guangming [University of Virginia, Department of Radiology, Neuroradiology Division, Charlottesville, VA (United States); Military General Hospital of Beijing PLA, Department of Neurology, Beijing (China); Hou, Qinghua [University of Virginia, Department of Radiology, Neuroradiology Division, Charlottesville, VA (United States); The Second Affiliated Hospital of Guangzhou Medical University, Department of Neurology, Guangzhou (China); Michel, Patrik; Eskandari, Ashraf [Centre Hospitalier Universitaire Vaudois, Department of Neurology, Lausanne (Switzerland); Jovin, Tudor [University of Pittsburgh, Department of Neurology, Pittsburgh, PA (United States); Xian, Junfang; Wang, Zhenchang [Capital Medical University, Department of Radiology, Beijing Tongren Hospital, Beijing (China); Wintermark, Max [University of Virginia, Department of Radiology, Neuroradiology Division, Charlottesville, VA (United States); Centre Hospitalier Universitaire Vaudois, Department of Radiology, Lausanne (Switzerland); Stanford University, Department of Radiology, Neuroradiology Division, Stanford, CA (United States)


    Perfusion-CT (PCT) processing involves deconvolution, a mathematical operation that computes the perfusion parameters from the PCT time density curves and an arterial curve. Delay-sensitive deconvolution does not correct for arrival delay of contrast, whereas delay-insensitive deconvolution does. The goal of this study was to compare delay-sensitive and delay-insensitive deconvolution PCT in terms of delineation of the ischemic core and penumbra. We retrospectively identified 100 patients with acute ischemic stroke who underwent admission PCT and CT angiography (CTA), a follow-up vascular study to determine recanalization status, and a follow-up noncontrast head CT (NCT) or MRI to calculate final infarct volume. PCT datasets were processed twice, once using delay-sensitive deconvolution and once using delay-insensitive deconvolution. Regions of interest (ROIs) were drawn, and cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) in these ROIs were recorded and compared. Volume and geographic distribution of ischemic core and penumbra using both deconvolution methods were also recorded and compared. MTT and CBF values are affected by the deconvolution method used (p < 0.05), while CBV values remain unchanged. Optimal thresholds to delineate ischemic core and penumbra are different for delay-sensitive (145 % MTT, CBV 2 ml x 100 g{sup -1} x min{sup -1}) and delay-insensitive deconvolution (135 % MTT, CBV 2 ml x 100 g{sup -1} x min{sup -1} for delay-insensitive deconvolution). When applying these different thresholds, however, the predicted ischemic core (p = 0.366) and penumbra (p = 0.405) were similar with both methods. Both delay-sensitive and delay-insensitive deconvolution methods are appropriate for PCT processing in acute ischemic stroke patients. The predicted ischemic core and penumbra are similar with both methods when using different sets of thresholds, specific for each deconvolution method. (orig.)

  19. Time delays across saddles as a test of modified gravity

    Magueijo, Joao


    Modified gravity theories can produce strong signals in the vicinity of the saddles of the total gravitational potential. In a sub-class of these models this translates into diverging time-delays for echoes crossing the saddles. Such models arise from the possibility that gravity might be infrared divergent or confined, and if suitably designed they are very difficult to rule out. We show that Lunar Laser Ranging during an eclipse could probe the time-delay effect within meters of the saddle, thereby proving or excluding these models. Very Large Baseline Interferometry, instead, could target delays across the Jupiter-Sun saddle. Such experiments would shed light on the infrared behaviour of gravity and examine the puzzling possibility that there might be well-hidden regions of strong gravity and even singularities inside the solar system.

  20. Delay locked loop integrated circuit.

    Brocato, Robert Wesley


    This report gives a description of the development of a Delay Locked Loop (DLL) integrated circuit (IC). The DLL was developed and tested as a stand-alone IC test chip to be integrated into a larger application specific integrated circuit (ASIC), the Quadrature Digital Waveform Synthesizer (QDWS). The purpose of the DLL is to provide a digitally programmable delay to enable synchronization between an internal system clock and external peripherals with unknown clock skew. The DLL was designed and fabricated in the IBM 8RF process, a 0.13 {micro}m CMOS process. It was designed to operate with a 300MHz clock and has been tested up to 500MHz.

  1. Time delay and distance measurement

    Abshire, James B. (Inventor); Sun, Xiaoli (Inventor)


    A method for measuring time delay and distance may include providing an electromagnetic radiation carrier frequency and modulating one or more of amplitude, phase, frequency, polarization, and pointing angle of the carrier frequency with a return to zero (RZ) pseudo random noise (PN) code. The RZ PN code may have a constant bit period and a pulse duration that is less than the bit period. A receiver may detect the electromagnetic radiation and calculate the scattering profile versus time (or range) by computing a cross correlation function between the recorded received signal and a three-state RZ PN code kernel in the receiver. The method also may be used for pulse delay time (i.e., PPM) communications.

  2. Neuroticism Delays Detection of Facial Expressions.

    Sawada, Reiko; Sato, Wataru; Uono, Shota; Kochiyama, Takanori; Kubota, Yasutaka; Yoshimura, Sayaka; Toichi, Motomi


    The rapid detection of emotional signals from facial expressions is fundamental for human social interaction. The personality factor of neuroticism modulates the processing of various types of emotional facial expressions; however, its effect on the detection of emotional facial expressions remains unclear. In this study, participants with high- and low-neuroticism scores performed a visual search task to detect normal expressions of anger and happiness, and their anti-expressions within a crowd of neutral expressions. Anti-expressions contained an amount of visual changes equivalent to those found in normal expressions compared to neutral expressions, but they were usually recognized as neutral expressions. Subjective emotional ratings in response to each facial expression stimulus were also obtained. Participants with high-neuroticism showed an overall delay in the detection of target facial expressions compared to participants with low-neuroticism. Additionally, the high-neuroticism group showed higher levels of arousal to facial expressions compared to the low-neuroticism group. These data suggest that neuroticism modulates the detection of emotional facial expressions in healthy participants; high levels of neuroticism delay overall detection of facial expressions and enhance emotional arousal in response to facial expressions.

  3. Assembly delay line pulse generators


    Assembly of six of the ten delay line pulse generators that will power the ten kicker magnet modules. One modulator part contains two pulse generators. Capacitors, inductances, and voltage dividers are in the oil tank on the left. Triggered high-pressure spark gap switches are on the platforms on the right. High voltage pulse cables to the kicker magnet emerge under the spark gaps. In the centre background are the assembled master gaps.

  4. Six Channel Digital Delay Generator


    Historically, delays were generated by R-C networks that fired thyratrons to provide the re- quired output pulses. Because of severe electrical interference...instruction manual. The system clock was an M. F. electronics model 5401-1 in a printed circuit mounting package. This particular model has a 10 MHz...constructed in-house to provide the high voltages required to trip flash x-ray systems and thyratron controlled firing units. Details of this circuit are

  5. Teriparatide Induced Delayed Persistent Hypercalcemia

    Nirosshan Thiruchelvam


    Full Text Available Teriparatide, a recombinant PTH, is an anabolic treatment for osteoporosis that increases bone density. Transient hypercalcemia is a reported side effect of teriparatide that is seen few hours following administration of teriparatide and resolves usually within 16 hours of drug administration. Persistent hypercalcemia, although not observed in clinical trials, is rarely reported. The current case describes a rare complication of teriparatide induced delayed persistent hypercalcemia.

  6. A quantum delayed choice experiment

    Peruzzo, Alberto; Brunner, Nicolas; Popescu, Sandu; O'Brien, Jeremy L


    Quantum systems exhibit particle-like or wave-like behaviour depending on the experimental apparatus they are confronted by. This wave-particle duality is at the heart of quantum mechanics, and is fully captured in Wheeler's famous delayed choice gedanken experiment. In this variant of the double slit experiment, the observer chooses to test either the particle or wave nature of a photon after it has passed through the slits. Here we report on a quantum delayed choice experiment, based on a quantum controlled beam-splitter, in which both particle and wave behaviours can be investigated simultaneously. The genuinely quantum nature of the photon's behaviour is tested via a Bell inequality, which here replaces the delayed choice of the observer. We observe strong Bell inequality violations, thus showing that no model in which the photon knows in advance what type of experiment it will be confronted by, hence behaving either as a particle or as wave, can account for the experimental data.

  7. Effectiveness of diagnostic strategies in suspected delayed cerebral ischemia : A decision analysis

    Rawal, Sapna; Barnett, Carolina; John-Baptiste, Ava; Thein, Hla Hla; Krings, Timo; Rinkel, Gabriel J E


    Background and Purpose-Delayed cerebral ischemia (DCI) is a serious complication after aneurysmal subarachnoid hemorrhage. If DCI is suspected clinically, imaging Methods designed to detect angiographic vasospasm or regional hypoperfusion are often used before instituting therapy. Uncertainty in the

  8. β-delayed Multi-particle Emission From 31Ar

    A. A. Ciemny; J. Du´enas-Daz; V. Dunin; J. M. Espino; A. Estrade; F. Farinon; A. Fomichev; H. Geisse; A. Gorshkov; G. Kami´nski; O. Kiselev; C. Mazzocchi; R. Kn¨obe; S. Krupko; M. Kuich; Yu. A. Litvinov; G. Marquinez-Dur´an; I. Martel; I. Mukha; C. Nociforo; A. K. Ord´uz; S. Pietri; W. Dominik; A. Prochazka; A. M. S´anchez-Ben´ıtez; H. Simon; B. Sitar; R. Slepnev; M. Stanoiu; P. Strmen; I. Szarka; M. Takechi; Y. Tanaka; Z. Janas; H. Weick; J. S. Winfield; M. Pf¨utzner; M. Pomorski; L. Acosta; S. Baraeva; E. Casarejos


    The β+ decay of 31Ar was investigated in an experiment at the GSI-FRS spectrometer. The ions of interest have been produced in the fragmentation of a 36Ar beam at 880 MeV/nucleon and implanted in a time projection chamber with optical readout. In addition to β-delayed one and two proton emission, for the first time the emission ofβ-delayed 3 protons has been observed. The branching ratio for this decay mode is found to be (0.07 ± 0.02)%.

  9. Reconfigurable diplexer based on switched delay line approach

    Zhurbenko, Vitaliy; Acar, Öncel; Ruaro, Andrea;


    In this work, a concept for the realization of a reconfigurable microwave multiplexer based on a switched delay-line topology is presented. The multiplexing concept is studied by considering a diplexer example. The topology provides two times reduction in the number of filters in comparison...... to the conventional directional filter approach. The switched delay-line topology enables the lossy and nonlinear switching elements to be used as a part of the coupling elements rather than within the resonators. Therefore, the diplexer potentially allows for a low insertion loss and high linearity. In addition...

  10. Data Mining for Understanding and Impriving Decision-Making Affecting Ground Delay Programs

    Kulkarni, Deepak; Wang, Yao Xun; Sridhar, Banavar


    The continuous growth in the demand for air transportation results in an imbalance between airspace capacity and traffic demand. The airspace capacity of a region depends on the ability of the system to maintain safe separation between aircraft in the region. In addition to growing demand, the airspace capacity is severely limited by convective weather. During such conditions, traffic managers at the FAA's Air Traffic Control System Command Center (ATCSCC) and dispatchers at various Airlines' Operations Center (AOC) collaborate to mitigate the demand-capacity imbalance caused by weather. The end result is the implementation of a set of Traffic Flow Management (TFM) initiatives such as ground delay programs, reroute advisories, flow metering, and ground stops. Data Mining is the automated process of analyzing large sets of data and then extracting patterns in the data. Data mining tools are capable of predicting behaviors and future trends, allowing an organization to benefit from past experience in making knowledge-driven decisions. The work reported in this paper is focused on ground delay programs. Data mining algorithms have the potential to develop associations between weather patterns and the corresponding ground delay program responses. If successful, they can be used to improve and standardize TFM decision resulting in better predictability of traffic flows on days with reliable weather forecasts. The approach here seeks to develop a set of data mining and machine learning models and apply them to historical archives of weather observations and forecasts and TFM initiatives to determine the extent to which the theory can predict and explain the observed traffic flow behaviors.

  11. Indigenous mothers face more than three delays: The challenges of multiculturalism in health

    Roosta-G., Manigeh


    Full Text Available Although the maternal mortality ratio has descended in Bolivia from 416 (1989 to 229 deaths (DHS 2003 per one hundred thousand live births, it is one of the highest in the region. As a national average, the ratio conceals the rural-urban, socio-economics differences and the reality of the indigenous population. Maternal mortality is one of the major challenges at national level. Reduction of maternal mortality, in addition of technical-medical measures offering health services, requires to focus on socio-cultural aspects that hamper the access to health services. This article examines challenges faced by indigenous mothers accessing the health services. In addition to the geographic, economic and administrative barriers that generate delays in access to the health services, there are others that are presented in the context of multiculturalism resulting from discriminatory attitudes exercised in health centers. The testimonies of indigenous mothers show delays faced in health centers because of prejudice and discrimination suffered, threatening the lives of mothers and their babies. The study also suggests the need to deepen the concept of multiculturalism as a successful strategy in health, in order to promote equity and social justice on the horizon of more inclusive societies.

  12. On Hamlet's Delay in the Revenge



    Hamlet is a representative tragedy written by Shakespeare. Question on Hemlet's delay has been drawing the interest of many literature critics. It is still under discussion today. This thesis focuses on analyzing the reasons for Hamlet's delay in the revenge.

  13. Coherent Pattern Prediction in Swarms of Delay-Coupled Agents

    Mier-y-Teran-Romero, Luis; Forgoston, Eric; Schwartz, Ira B.


    We consider a general swarm model of self-propelling agents interacting through a pairwise potential in the presence of noise and communication time delay. Previous work has shown that a communication time delay in the swarm induces a pattern bifurcation that depends on the size of the coupling amplitude. We extend these results by completely unfolding the bifurcation structure of the mean field approximation. Our analysis reveals a direct correspondence between the different dynamical behaviors found in different regions of the coupling-time delay plane with the different classes of simulated coherent swarm patterns. We derive the spatiotemporal scales of the swarm structures, as well as demonstrate how the complicated interplay of coupling strength, time delay, noise intensity, and choice of initial conditions can affect the swarm. In particular, our studies show that for sufficiently large values of the coupling strength and/or the time delay, there is a noise intensity threshold that forces a transition of the swarm from a misaligned state into an aligned state. We show that this alignment transition exhibits hysteresis when the noise intensity is taken to be time dependent. PMID:24255625

  14. Chaotic time series prediction and additive white Gaussian noise

    Lim, Teck Por [Department of Mathematics, 6M30 Huxley, Imperial College London, 180 Queen' s Gate, London, SW7 2BZ (United Kingdom)]. E-mail:; Puthusserypady, Sadasivan [Department of Electrical and Computer Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore 117576 (Singapore)]. E-mail:


    Taken's delay embedding theorem states that a pseudo state-space can be reconstructed from a time series consisting of observations of a chaotic process. However, experimental observations are inevitably corrupted by measurement noise, which can be modelled as Additive White Gaussian Noise (AWGN). This Letter analyses time series prediction in the presence of AWGN using the triangle inequality and the mean of the Nakagami distribution. It is shown that using more delay coordinates than those used by a typical delay embedding can improve prediction accuracy, when the mean magnitude of the input vector dominates the mean magnitude of AWGN.

  15. Absolute stability of nonlinear systems with time delays and applications to neural networks

    Xinzhi Liu


    Full Text Available In this paper, absolute stability of nonlinear systems with time delays is investigated. Sufficient conditions on absolute stability are derived by using the comparison principle and differential inequalities. These conditions are simple and easy to check. In addition, exponential stability conditions for some special cases of nonlinear delay systems are discussed. Applications of those results to cellular neural networks are presented.

  16. The binding site for regulatory 14-3-3 protein in plant plasma membrane H+-ATPase: Involvement of a region promoting phosphorylation-independent interaction in addition to the phosphorylation-dependent C-terminal end

    Fuglsang, Anja T; Borch, Jonas; Bych, Katrine;


    of the Arabidopsis plasma membrane H+-ATPase isoform 2 (AHA2). Following site-directed mutagenesis within the 45 C-terminal residues of AHA2, we conclude that, in addition to the 946YpTV motif, a number of residues located further upstream are required for phosphorylation-independent binding of 14-3-3. Among these...

  17. Time Delay Effects on Coupled Limit Cycle Oscillators at Hopf Bifurcation

    Reddy, D V R; Johnston, G L


    We present a detailed study of the effect of time delay on the collective dynamics of coupled limit cycle oscillators at Hopf bifurcation. For a simple model consisting of just two oscillators with a time delayed coupling, the bifurcation diagram obtained by numerical and analytical solutions shows significant changes in the stability boundaries of the amplitude death, phase locked and incoherent regions. A novel result is the occurrence of amplitude death even in the absence of a frequency mismatch between the two oscillators. Similar results are obtained for an array of N oscillators with a delayed mean field coupling and the regions of such amplitude death in the parameter space of the coupling strength and time delay are quantified. Some general analytic results for the N tending to infinity (thermodynamic) limit are also obtained and the implications of the time delay effects for physical applications are discussed.

  18. Stability of adaptive cruise control systems taking account of vehicle response time and delay

    Davis, L.C., E-mail: [10244 Normandy Dr., Plymouth, MI 48170 (United States)


    The region of string stability of a platoon of adaptive cruise control vehicles, taking into account the delay and response of the vehicle powertrain, is found. An upper bound on the explicit delay time as a function the first-order powertrain response time constant is determined. The system is characterized by a headway time constant, a sensitivity parameter, relative (to the vehicle immediately in front) velocity control, and delayed-velocity feedback or acceleration feedback. -- Highlights: ► I find the region of stability for a realistic adaptive cruise control system. ► Vehicle response time and explicit delay are included in the analysis. ► Delayed-feedback enlarges the parameter space that gives string stability.

  19. Stimulus Frequency Otoacoustic Emission Delays and Generating Mechanisms in Guinea Pigs, Chinchillas, and Simulations.

    Berezina-Greene, Maria A; Guinan, John J


    According to coherent reflection theory (CRT), stimulus frequency otoacoustic emissions (SFOAEs) arise from cochlear irregularities coherently reflecting energy from basilar membrane motion within the traveling-wave peak. This reflected energy arrives in the ear canal predominantly with a single delay at each frequency. However, data from humans and animals indicate that (1) SFOAEs can have multiple delay components, (2) low-frequency SFOAE delays are too short to be accounted for by CRT, and (3) "SFOAEs" obtained with a 2nd ("suppressor") tone ≥2 octaves above the probe tone have been interpreted as arising from the area basal to the region of cochlear amplification. To explore these issues, we collected SFOAEs by the suppression method in guinea pigs and time-frequency analyzed these data, simulated SFOAEs, and published chinchilla SFOAEs. Time-frequency analysis revealed that most frequencies showed only one SFOAE delay component while other frequencies had multiple components including some with short delays. We found no systematic patterns in the occurrence of multiple delay components. Using a cochlear model that had significant basilar membrane motion only in the peak region of the traveling wave, simulated SFOAEs had single and multiple delay components similar to the animal SFOAEs. This result indicates that multiple components (including ones with short delays) can originate from cochlear mechanical irregularities in the SFOAE peak region and are not necessarily indicative of SFOAE sources in regions ≥2 octaves basal of the SFOAE peak region. We conclude that SFOAEs obtained with suppressors close to the probe frequency provide information primarily about the mechanical response in the region that receives amplification, and we attribute the too-short SFOAE delays at low frequencies to distortion-source SFOAEs and coherent reflection from multiple cochlear motions. Our findings suggest that CRT needs revision to include reflections from multiple

  20. Epidemiology, diagnostic delay and outcome of tuberculosis in North Jutland, Denmark

    Andersen, Lene Rosa-Marie; Bjørn-Præst, Simon O; Gradel, Kim O;


    The objective of this study was to evaluate the clinical outcome of tuberculosis (TB) with regards to epidemiology, symptoms, delay, diagnostics, use of HIV-test, treatment, treatment outcome and mortality in the North Jutland Region from 2000 through 2008.......The objective of this study was to evaluate the clinical outcome of tuberculosis (TB) with regards to epidemiology, symptoms, delay, diagnostics, use of HIV-test, treatment, treatment outcome and mortality in the North Jutland Region from 2000 through 2008....

  1. Synchronization analysis of coloured delayed networks under decentralized pinning intermittent control



    This paper investigates synchronization of coloured delayed networks under decentralized pinning intermittent control. To begin with, the time delays are taken into account in the coloured networks. In addition, we propose a decentralized pinning intermittent control for coloured delayed networks, which is different from that most of pinning intermittent controls are only appliedto the nodes from 1 to l or centralized nodes. Moreover, sufficient conditions are derived to guarantee the synchronization of coloured delayed networks based on Lyapunov stability theorem. Finally, numerical simulations are provided to verify the validity of the obtained results.

  2. Modelling delay propagation within an airport network

    Pyrgiotis, N.; Malone, K.M.; Odoni, A.


    We describe an analytical queuing and network decomposition model developed to study the complex phenomenon of the propagation of delays within a large network of major airports. The Approximate Network Delays (AND) model computes the delays due to local congestion at individual airports and capture

  3. 前牙即刻种植和常规种植修复2年后软、硬组织稳定性比较%Comparison of soft and hard tissue stability between immediate implant and delayed implant in maxillary anterior region after loading 2 years

    吴敏节; 张相皞; 邹立东; 梁峰


    目的:比较前牙区即刻种植和常规种植两组病例在修复2年后其软、硬组织稳定性的差异。方法:选择2010年10月至2011年12月来北京大学口腔医院第二门诊部就诊的拟在前牙区1~2颗不相邻的牙位进行种植治疗的健康患者38名,共植入43颗种植体。在行种植上部修复前均采用种植体支持的临时冠进行牙龈形态的诱导,直至永久修复完成。在修复即刻及2年后测量近远中牙龈乳头、唇侧龈缘水平高度以及种植体近远中侧骨水平的变化。结果:前牙即刻种植组完成16例,植入种植体17颗;常规种植组完成22例,植入种植体26颗。两组病例在永久修复前种植体稳定性系数值(implant stability quotient,ISQ)差异无统计学意义(P>0.05)。即刻种植组和常规种植组在修复2年后近中龈乳头高度平均增高分别为(0.15±0.42) mm和(0.06±0.65) mm,远中龈乳头高度平均增高分别为(0.06±0.50) mm和(0.02±0.57) mm;唇侧龈缘水平平均丧失分别为(0.15±0.23) mm和(0.15±0.46)mm;种植体骨吸收量在近中侧分别为(0.67±0.35)mm和(0.69±0.49)mm,远中侧分别为(0.73±0.31)mm和(0.75±0.48)mm;两组间差异均无统计学意义(P>0.05)。结论:两组病例在修复后2年内都显示出良好的效果,其软、硬组织均很稳定,提示这两种方法都可以获得可靠的修复效果。在严格掌握适应征的前提下,前牙区的即刻种植与常规种植在修复后的近期效果相当,但即刻种植在缩短疗程方面显然要优于常规种植。%Objective: To compare the peri-implant tissue stability between immediate implant and delayed implant in maxillary anterior region after loading 2 years.Methods: In the study, 38 patients with single anterior tooth loss in the Second Clinical Division of Peking University School and

  4. A Cucker--Smale Model with Noise and Delay

    Erban, Radek


    A generalization of the Cucker-Smale model for collective animal behavior is investigated. The model is formulated as a system of delayed stochastic differential equations. It incorporates two additional processes which are present in animal decision making, but are often neglected in modeling: (i) stochasticity (imperfections) of individual behavior and (ii) delayed responses of individuals to signals in their environment. Sufficient conditions for flocking for the generalized Cucker-Smale model are derived by using a suitable Lyapunov functional. As a by-product, a new result regarding the asymptotic behavior of delayed geometric Brownian motion is obtained. In the second part of the paper, results of systematic numerical simulations are presented. They not only illustrate the analytical results, but hint at a somehow surprising behavior

  5. Delay time calculation for dual-wavelength quantum cascade lasers

    Hamadou, A., E-mail: [Département des Sciences et Techniques, Faculté des Sciences et de la Technologie, Université de Bordj Bou Arreridj 34000 (Algeria); Laboratoire d’étude des surfaces et interfaces des matériaux solides (LESIMS), Sétif 19000 (Algeria); Lamari, S. [Laboratoire d’étude des surfaces et interfaces des matériaux solides (LESIMS), Sétif 19000 (Algeria); Département de Physique, Faculté des Sciences, Université Sétif 1, 19000 (Algeria); Thobel, J.-L. [Institut d' Electronique, de Microélectronique et de Nanotechnologie (IEMN), UMR 8520, Université Lille1, Avenue Poincaré, BP 60069, 59652 Villeneuve d' Ascq Cédex (France)


    In this paper, we calculate the turn-on delay (t{sub th}) and buildup (Δt) times of a midinfrared quantum cascade laser operating simultaneously on two laser lines having a common upper level. The approach is based on the four-level rate equations model describing the variation of the electron number in the states and the photon number present within the cavity. We obtain simple analytical formulae for the turn-on delay and buildup times that determine the delay times and numerically apply our results to both the single and bimode states of a quantum cascade laser, in addition the effects of current injection on t{sub th} and Δt are explored.

  6. Dendrin ablation prolongs life span by delaying kidney failure.

    Weins, Astrid; Wong, Jenny S; Basgen, John M; Gupta, Ritu; Daehn, Ilse; Casagrande, Lisette; Lessman, David; Schwartzman, Monica; Meliambro, Kristin; Patrakka, Jaakko; Shaw, Andrey; Tryggvason, Karl; He, John Cijiang; Nicholas, Susanne B; Mundel, Peter; Campbell, Kirk N


    Podocyte loss is central to the progression of proteinuric kidney diseases leading to end-stage kidney disease (ESKD), requiring renal replacement therapy, such as dialysis. Despite modern tools and techniques, the 5-year mortality of some patients requiring dialysis remains at about 70% to 80%. Thus, there is a great unmet need for podocyte-specific treatments aimed at preventing podocyte loss and the ensuing development of ESKD. Here, we show that ablation of the podocyte death-promoting protein dendrin delays the onset of ESKD, thereby expanding the life span of mice lacking the adapter protein CD2AP. Ablation of dendrin delays onset and severity of proteinuria and podocyte loss. In addition, dendrin ablation ameliorates mesangial volume expansion and up-regulation of mesangial fibronectin expression, which is mediated by a podocyte-secreted factor. In conclusion, onset of ESKD and death can be markedly delayed by blocking the function of dendrin.

  7. Delay-enhanced coherence of spiral waves in noisy Hodgkin-Huxley neuronal networks

    Wang Qingyun [State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics and Aerospace Engineering, College of Engineering, Peking University, Beijing 100871 (China) and School of Statistics and Mathematics, Inner Mongolia Finance and Economics College, Huhhot 010051 (China)], E-mail:; Perc, Matjaz [Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Koroska cesta 160, SI-2000 Maribor (Slovenia); Duan Zhisheng [State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics and Aerospace Engineering, College of Engineering, Peking University, Beijing 100871 (China); Chen Guanrong [State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics and Aerospace Engineering, College of Engineering, Peking University, Beijing 100871 (China); Department of Electronic Engineering, City University of Hong Kong, Hong Kong (China)


    We study the spatial dynamics of spiral waves in noisy Hodgkin-Huxley neuronal ensembles evoked by different information transmission delays and network topologies. In classical settings of coherence resonance the intensity of noise is fine-tuned so as to optimize the system's response. Here, we keep the noise intensity constant, and instead, vary the length of information transmission delay amongst coupled neurons. We show that there exists an intermediate transmission delay by which the spiral waves are optimally ordered, hence indicating the existence of delay-enhanced coherence of spatial dynamics in the examined system. Additionally, we examine the robustness of this phenomenon as the diffusive interaction topology changes towards the small-world type, and discover that shortcut links amongst distant neurons hinder the emergence of coherent spiral waves irrespective of transmission delay length. Presented results thus provide insights that could facilitate the understanding of information transmission delay on realistic neuronal networks.

  8. Leapfrog: Optimal opportunistic Routing in Probabilistically Contacted Delay Tolerant Networks

    Ming-Jun Xiao; Liu-Sheng Huang; Qun-Feng Dong; An Liu; Zhen-Guo Yang


    Delay tolerant networks (DTNs)experience frequent and long lasting network disconnection due to various reasons such as mobility.power management.and scheduling.One primary concern in DTNs is to route messages to keep the end-to-end delivery delay as low as possible.In this paper,we study the single-copy message routing problem and propose an optimal opportunistic routing strategy--Leapfrog Routing--for probabilistically contacted DTNs where nodes encounter or contact in some fixed probabilities.We deduce the iterative computation formulate of minimum expected opportunistic delivery delay from each node to the destination and discover that under the optimal opportunistic routing strategy,messages would be delivered from high-delay node to low-delay node in the leapfrog manner.Rigorous theoretical analysis shows that such a routing strategy is exactly the optimal among all possible ones.Moreover,we apply the idea of Reverse Dijkstra algorithm to design an algorithm.When a destination iS given,this algorithm can determine for each node the routing selection function under the Leapfrog Routing strategy.The computation overhead of this algorithm is only O(n~2) where n is the number of nodes in the network.In addition,through extensive simulations based on real DTN traces,we demonstrate that our algorithm can significantly outperform the previous ones.

  9. BOLD delay times using group delay in sickle cell disease

    Coloigner, Julie; Vu, Chau; Bush, Adam; Borzage, Matt; Rajagopalan, Vidya; Lepore, Natasha; Wood, John


    Sickle cell disease (SCD) is an inherited blood disorder that effects red blood cells, which can lead to vasoocclusion, ischemia and infarct. This disease often results in neurological damage and strokes, leading to morbidity and mortality. Functional Magnetic Resonance Imaging (fMRI) is a non-invasive technique for measuring and mapping the brain activity. Blood Oxygenation Level-Dependent (BOLD) signals contain also information about the neurovascular coupling, vascular reactivity, oxygenation and blood propagation. Temporal relationship between BOLD fluctuations in different parts of the brain provides also a mean to investigate the blood delay information. We used the induced desaturation as a label to profile transit times through different brain areas, reflecting oxygen utilization of tissue. In this study, we aimed to compare blood flow propagation delay times between these patients and healthy subjects in areas vascularized by anterior, middle and posterior cerebral arteries. In a group comparison analysis with control subjects, BOLD changes in these areas were found to be almost simultaneous and shorter in the SCD patients, because of their increased brain blood flow. Secondly, the analysis of a patient with a stenosis on the anterior cerebral artery indicated that signal of the area vascularized by this artery lagged the MCA signal. These findings suggest that sickle cell disease causes blood propagation modifications, and that these changes could be used as a biomarker of vascular damage.

  10. [Food additives and healthiness].

    Heinonen, Marina


    Additives are used for improving food structure or preventing its spoilage, for example. Many substances used as additives are also naturally present in food. The safety of additives is evaluated according to commonly agreed principles. If high concentrations of an additive cause adverse health effects for humans, a limit of acceptable daily intake (ADI) is set for it. An additive is a risk only when ADI is exceeded. The healthiness of food is measured on the basis of nutrient density and scientifically proven effects.

  11. H∞ State Feedback Delay-dependent Control for Discrete Systems with Multi-time-delay

    Bai-Da Qu


    In this paper,H∞ state feedback control with delay information for discrete systems with multi-time-delay is discussed. Making use of linear matrix inequality (LMI) approach, a time-delay-dependent criterion for a discrete system with multi-time-delay to satisfy H∞ performance indices is induced, and then a strategy for H∞ state feedback control with delay values for plant with multi-time-delay is obtained. By solving corresponding LMI, a delay-dependent state feedback controller satisfying H∞ performance indices is designed. Finally, a simulation example demonstrates the validity of the proposed approach.

  12. Reactor shutdown delays medical procedures

    Gwynne, Peter


    A longer-than-expected maintenance shutdown of the Canadian nuclear reactor that produces North America's entire supply of molybdenum-99 - from which the radioactive isotopes technetium-99 and iodine-131 are made - caused delays to the diagnosis and treatment of thousands of seriously ill patients last month. Technetium-99 is a key component of nuclear-medicine scans, while iodine-131 is used to treat cancer and other diseases of the thyroid. Production eventually resumed, but only after the Canadian government had overruled the Canadian Nuclear Safety Commission (CNSC), which was still concerned about the reactor's safety.

  13. Additions to generating capacity 1978--1987 for the contiguous United States: as projected by the Regional Electric Reliability Councils in their April 1, 1978 long-range coordinated planning reports to the Department of Energy


    Comparison of the 1978 projections of the Reliability Councils with those made the previous year indicates three major changes in electric utility planning: (1) a reduction in total capacity additions for the 10-year planning period, (2) a significant decrease in nuclear additions, and (3) a shift from oil and gas to coal as a source of primary energy. Nuclear capacity continues to far overshadow fossil-fuel capacity in the unit-size range 1000 MW and up, with the reverse true for unit sizes less than 1000 MW. Although the total 10-year new-unit capacity drops from 326,624 MW (1977 to 1986) to 308,017 (1978 to 1987), new capacity planned that would use coal as a primary energy source increases from 136,763 MW to 146,206 MW. Nuclear capacity, in terms of total new units projected for the two 10-year periods, decreases from 130,532 MW to 116,177 MW, and capacity with oil as the primary source drops from 32,837 MW to 21,072 MW. For 1977 to 1986, no capacity was planned with oil as a primary source and coal as an alternate fuel but for 1978 to 1987, 1220 MW of such capacity is projected. Therefore, the total new capacity projected that could use coal as a fuel (primary or alternate) is 147,426 MW. In addition, one 700-MW unit is planned for which the primary fuel will be a blend of coal and refuse. There is a decrease in the capacity planned that would use natural gas a a primary source, from 2,089 MW in 1977 to 1986 to 502 MW in 1978 to 1987.

  14. Asymptotic Delay Analysis for Cross-Layer Delay-Based Routing in Ad Hoc Networks

    Philippe Jacquet


    Full Text Available This paper addresses the problem of the evaluation of the delay distribution via analytical means in IEEE 802.11 wireless ad hoc networks. We show that the asymptotic delay distribution can be expressed as a power law. Based on the latter result, we present a cross-layer delay estimation protocol and we derive new delay-distribution-based routing algorithms, which are well adapted to the QoS requirements of real-time multimedia applications. In fact, multimedia services are not sensitive to average delays, but rather to the asymptotic delay distributions. Indeed, video streaming applications drop frames when they are received beyond a delay threshold, determined by the buffer size. Although delay-distribution-based routing is an NP-hard problem, we show that it can be solved in polynomial time when the delay threshold is large, because of the asymptotic power law distribution of the link delays.

  15. Delay-Dependent Observers for Uncertain Nonlinear Time-Delay Systems

    Dongmei Yan


    Full Text Available This paper is concerned with the observer design problem for a class of discrete-time uncertain nonlinear systems with time-varying delay. The nonlinearities are assumed to satisfy global Lipschitz conditions which appear in both the state and measurement equations. The uncertainties are assumed to be time-varying but norm-bounded. Two Luenberger-like observers are proposed. One is delay observer and the other is delay-free observer. The delay observer which has an internal time delay is applicable when the time delay is known. The delay-free observer which does not use delayed information is especially applicable when the time delay is not known explicitly. Delay-dependent conditions for the existences of these two observers are derived based on Lyapunpv functional approach. Based on these conditions, the observer gains are obtained using the cone complementarity linearization algorithm. Finally, a numerical example is given to illustrate the effectiveness of the proposed method.

  16. Estimation of time delay by coherence analysis

    Govindan, R B; Kopper, F; Claussen, J C; Deuschl, G


    Using coherence analysis (which is an extensively used method to study the correlations in frequency domain, between two simultaneously measured signals) we estimate the time delay between two signals. This method is suitable for time delay estimation of narrow band coherence signals for which the conventional methods cannot be reliably applied. We show by analysing coupled R\\"ossler attractors with a known delay, that the method yields satisfactory results. Then, we apply this method to human pathologic tremor. The delay between simultaneously measured traces of Electroencephalogram (EEG) and Electromyogram (EMG) data of subjects with essential hand tremor is calculated. We find that there is a delay of 11-27 milli-seconds ($ms$) between the tremor correlated parts (cortex) of the brain (EEG) and the trembling hand (EMG) which is in agreement with the experimentally observed delay value of 15 $ms$ for the cortico-muscular conduction time. By surrogate analysis we calculate error-bars of the estimated delay.

  17. Synchronization of time-delay chaotic systems on small-world networks with delayed coupling

    Qi Wei; Wang Ying-Hai


    By using the well-known Ikeda model as the node dynamics,this paper studies synchronization of time-delay systems on small-world networks where the connections between units involve time delays.It shows that,in contrast with the undelayed case,networks with delays can actually synchronize more easily.Specifically,for randomly distributed delays,time-delayed mutual coupling suppresses the chaotic behaviour by stabilizing a fixed point that is unstable for the uncoupled dynamical system.

  18. Time-delay feedback control in a delayed dynamical chaos system and its applications

    Ye Zhi-Yong; Yang Guang; Deng Cun-Bing


    The feedback control of a delayed dynamical system, which also includes various chaotic systems with time delays, is investigated. On the basis of stability analysis of a nonautonomons system with delays, some simple yet less conservative criteria are obtained for feedback control in a delayed dynamical system. Finally, the theoretical result is applied to a typical class of chaotic Lorenz system and Chua circuit with delays. Numerical simulations are also given to verify the theoretical results.

  19. Additives in yoghurt production

    Milna Tudor


    Full Text Available In yoghurt production, mainly because of sensory characteristics, different types of additives are used. Each group, and also each substance from the same group has different characteristics and properties. For that reason, for improvement of yoghurt sensory characteristics apart from addition selection, the quantity of the additive is very important. The same substance added in optimal amount improves yoghurt sensory attributes, but too small or too big addition can reduce yoghurt sensory attributes. In this paper, characteristics and properties of mostly used additives in yoghurt production are described; skimmed milk powder, whey powder, concentrated whey powder, sugars and artificial sweeteners, fruits, stabilizers, casein powder, inulin and vitamins. Also the impact of each additive on sensory and physical properties of yoghurt, syneresis and viscosity, are described, depending on used amount added in yoghurt production.

  20. Photophysics of thermally activated delayed fluorescence molecules

    Dias, Fernando B.; Penfold, Thomas J.; Monkman, Andrew P.


    Thermally activated delayed fluorescence (TADF) has recently emerged as one of the most attractive methods for harvesting triplet states in metal-free organic materials for application in organic light emitting diodes (OLEDs). A large number of TADF molecules have been reported in the literature with the purpose of enhancing the efficiency of OLEDs by converting non-emissive triplet states into emissive singlet states. TADF emitters are able to harvest both singlets and triplet states through fluorescence (prompt and delayed), the latter due to the thermally activated reverse intersystem crossing mechanism that allows up-conversion of low energy triplet states to the emissive singlet level. This allows otherwise pure fluorescent OLEDs to overcome their intrinsic limit of 25% internal quantum efficiency (IQE), which is imposed by the 1:3 singlet–triplet ratio arising from the recombination of charges (electrons and holes). TADF based OLEDS with IQEs close to 100% are now routinely fabricated in the green spectral region. There is also significant progress for blue emitters. However, red emitters still show relatively low efficiencies. Despite the significant progress that has been made in recent years, still significant challenges persist to achieve full understanding of the TADF mechanism and improve the stability of these materials. These questions need to be solved in order to fully implement TADF in OLEDs and expand their application to other areas. To date, TADF has been exploited mainly in the field of OLEDs, but applications in other areas, such as sensing and fluorescence microscopies, are envisaged. In this review, the photophysics of TADF molecules is discussed, summarising current methods to characterise these materials and the current understanding of the TADF mechanism in various molecular systems.

  1. Wire + Arc Additive Manufacturing

    Williams, Stewart W.; Martina, Filomeno; Addison, Adrian C.; Ding, Jialuo; Pardal, Goncalo; Colegrove, Paul A.


    Depositing large components (>10 kg) in titanium, aluminium, steel and other metals is possible using Wire + Arc Additive Manufacturing. This technology adopts arc welding tools and wire as feedstock for additive manufacturing purposes. High deposition rates, low material and equipment costs, and good structural integrity make Wire+Arc Additive Manufacturing a suitable candidate for replacing the current method of manufacturing from solid billets or large forgings, especially with regards to ...

  2. Predicting Delayed Ventilator Weaning after Lung Transplantation: The Role of Body Mass Index

    Sarah Soh


    CONCLUSIONS: Low BMI might be associated with delayed ventilator weaning in lung transplantation patients. In addition, instead of the traditional weaning predictors of RSBI and RR, TV might be a better predictor for ventilator weaning after lung transplantation.

  3. Can Large Time Delays Observed in Light Curves of Coronal Loops be Explained by Impulsive Heating?

    Lionello, Roberto; Winebarger, Amy R; Linker, Jon A; Mikić, Zoran


    The light curves of solar coronal loops often peak first in channels associated with higher temperatures and then in those associated with lower. The time delays between the different narrowband EUV channels have been measured for many individual loops and recently for every pixel of an active region observation. Time delays between channels for an active region exhibit a wide range of values, with maxima $>$ 5,000\\,s. These large time delays make up 3-26\\% (depending on the channel pair) of the pixels where a significant, positive time delay is measured. It has been suggested that time delays can be explained by impulsive heating. In this paper, we investigate whether the largest observed time delays can be explained by this hypothesis by simulating a series of coronal loops with different heating rates, loop lengths, abundances, and geometries to determine the range of expected time delays between a set of four EUV channels. We find that impulsive heating cannot address the largest time delays observed in t...

  4. Fuzzy Association Degree with Delayed Time in Temporal Data Model

    刘惟一; 郭陵芝; 宋宁


    This paper presents an expression of the semantic proximity. Based on the temporal data model, a method of the temporal approximation is given. Using these concepts, this paper provides an evaluated method of fuzzy and dynamic association degree with delayed time and a superposition method of association degrees. Particularly, by means of the fuzzy and dynamic association degree, the connection between the weather data of two regions can be discovered.

  5. Transient brain ischemia: NMDA receptor modulation and delayed neuronal death

    Benquet, Pascal; Gee, Christine E.; Gerber, Urs


    Transient global ischemia induces delayed neuronal death in certain cell types and brain regions while sparing cells in other areas. A key process through which oxygen-glucose deprivation triggers cell death is the excessive accumulation of the neurotransmitter glutamate leading to over excitation of neurons. In certain neurons this increase in glutamate will potentiate the NMDA type of glutamate receptor, which can then initiate cell death. This review provides an update of the neurophysiolo...

  6. Improved visualization of delayed perfusion in lung MRI

    Risse, Frank [Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg (Germany); Eichinger, Monika [Department of Radiology, German Cancer Research Center, Heidelberg (Germany); Kauczor, Hans-Ulrich [Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg (Germany); Semmler, Wolfhard [Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg (Germany); Puderbach, Michael, E-mail: [Department of Radiology, German Cancer Research Center, Heidelberg (Germany)


    Introduction: The investigation of pulmonary perfusion by three-dimensional (3D) dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was proposed recently. Subtraction images are generated for clinical evaluation, but temporal information is lost and perfusion defects might therefore be masked in this process. The aim of this study is to demonstrate a simple analysis strategy and classification for 3D-DCE-MRI perfusion datasets in the lung without omitting the temporal information. Materials and methods: Pulmonary perfusion measurements were performed in patients with different lung diseases using a 1.5 T MR-scanner with a time-resolved 3D-GRE pulse sequence. 25 3D-volumes were acquired after iv-injection of 0.1 mmol/kg KG Gadolinium-DTPA. Three parameters were determined for each pixel: (1) peak enhancement S{sub n,max} normalized to the arterial input function to detect regions of reduced perfusion; (2) time between arterial peak enhancement in the large pulmonary artery and tissue peak enhancement {tau} to visualize regions with delayed bolus onset; and (3) ratio R = S{sub n,max}/{tau} was calculated to visualize impaired perfusion, irrespectively of whether related to reduced or delayed perfusion. Results: A manual selection of peak perfusion images is not required. Five different types of perfusion can be found: (1) normal perfusion; (2) delayed non-reduced perfusion; (3) reduced non-delayed perfusion; (4) reduced and delayed perfusion; and (5) no perfusion. Types II and IV could not be seen in subtraction images since the temporal information is necessary for this purpose. Conclusions: The analysis strategy in this study allows for a simple and observer-independent visualization and classification of impaired perfusion in dynamic contrast-enhanced pulmonary perfusion MRI by using the temporal information of the datasets.

  7. Polylactides in additive biomanufacturing.

    Poh, Patrina S P; Chhaya, Mohit P; Wunner, Felix M; De-Juan-Pardo, Elena M; Schilling, Arndt F; Schantz, Jan-Thorsten; van Griensven, Martijn; Hutmacher, Dietmar W


    New advanced manufacturing technologies under the alias of additive biomanufacturing allow the design and fabrication of a range of products from pre-operative models, cutting guides and medical devices to scaffolds. The process of printing in 3 dimensions of cells, extracellular matrix (ECM) and biomaterials (bioinks, powders, etc.) to generate in vitro and/or in vivo tissue analogue structures has been termed bioprinting. To further advance in additive biomanufacturing, there are many aspects that we can learn from the wider additive manufacturing (AM) industry, which have progressed tremendously since its introduction into the manufacturing sector. First, this review gives an overview of additive manufacturing and both industry and academia efforts in addressing specific challenges in the AM technologies to drive toward AM-enabled industrial revolution. After which, considerations of poly(lactides) as a biomaterial in additive biomanufacturing are discussed. Challenges in wider additive biomanufacturing field are discussed in terms of (a) biomaterials; (b) computer-aided design, engineering and manufacturing; (c) AM and additive biomanufacturing printers hardware; and (d) system integration. Finally, the outlook for additive biomanufacturing was discussed.

  8. Strong lensing, time delays, and the value of H$_0$

    Barnacka, Anna; Dell'antonio, Ian P; Benbow, Wystan


    In principle, the most straightforward method of estimating the Hubble constant relies on time delays between mirage images of strongly-lensed sources. It is a puzzle, then, that the values of H$_0$ obtained with this method span a range from $\\sim 50 - 100$ km s$^{-1}$Mpc$^{-1}$. Quasars monitored to measure these time delays, are multi-component objects. The variability may arise from different components of the quasar or may even originate from a jet. Misidentifying a variable emitting region in a jet with emission from the core region may introduce an error in the Hubble constant derived from a time delay. Here, we investigate the complex structure of sources as the underlying physical explanation of the wide spread in values of the Hubble constant based on gravitational lensing. Our Monte Carlo simulations demonstrate the potentially large impact of the position of the variable emitting region on H$_0$ determination. The derived value of the Hubble constant is very sensitive to the offset between the cen...

  9. Additive Gaussian Processes

    Duvenaud, David; Rasmussen, Carl Edward


    We introduce a Gaussian process model of functions which are additive. An additive function is one which decomposes into a sum of low-dimensional functions, each depending on only a subset of the input variables. Additive GPs generalize both Generalized Additive Models, and the standard GP models which use squared-exponential kernels. Hyperparameter learning in this model can be seen as Bayesian Hierarchical Kernel Learning (HKL). We introduce an expressive but tractable parameterization of the kernel function, which allows efficient evaluation of all input interaction terms, whose number is exponential in the input dimension. The additional structure discoverable by this model results in increased interpretability, as well as state-of-the-art predictive power in regression tasks.

  10. Conversion of linear time-invariant time-delay feedback systems into delay-differential equations with commensurate delays

    Yamazaki, Tatsuya; Hagiwara, Tomomichi


    A new stability analysis method of time-delay systems (TDSs) called the monodromy operator approach has been studied under the assumption that a TDS is represented as a time-delay feedback system consisting of a finite-dimensional linear time-invariant (LTI) system and a pure delay. For applying this approach to TDSs described by delay-differential equations (DDEs), the problem of converting DDEs into representation as time-delay feedback systems has been studied. With regard to such a problem, it was shown that, under discontinuous initial functions, it is natural to define the solutions of DDEs in two different ways, and the above conversion problem was solved for each of these two definitions. More precisely, the solution of a DDE was represented as either the state of the finite-dimensional part of a time-delay feedback system or a part of the output of another time-delay feedback system, depending on which definition of the DDE solution one is talking about. Motivated by the importance in establishing a thorough relationship between time-delay feedback systems and DDEs, this paper discusses the opposite problem of converting time-delay feedback systems into representation as DDEs, including the discussions about the conversion of the initial conditions. We show that the state of (the finite-dimensional part of) a time-delay feedback system can be represented as the solution of a DDE in the sense of one of the two definitions, while its 'essential' output can be represented as that of another DDE in the sense of the other type of definition. Rigorously speaking, however, it is also shown that the latter representation is possible regardless of the initial conditions, while some initial condition could prevent the conversion into the former representation. This study hence establishes that the representation of TDSs as time-delay feedback systems possesses higher ability than that with DDEs, as description methods for LTI TDSs with commensurate delays.

  11. Mixed delay-independent/delay-dependent stability of uncertain linear time-delayed systems

    LI Wenlin; DONG Rui


    @@ Consider uncertain linear time delay systems described by the following state equation: x(t)=[A0+Δ A0(t)]x(t)+∑ri=1[Ai+ΔAi(t)]x(t-τi).(1) x(t)=(t)t∈[-,0];=maxri=1{τi}(2) where Δ A0(*) and Δ Ai(*)(i=1,…,r) are real matrix functions.Δ Ai(t)=LiFi(t)Ei,ΔA0(t)=L0F0(t)E0, where Li,Ei are known real constant matrices and Fi(t) are unknown real time-varying matrices with Lebesgue measurable elements satisfying ‖Fi(t)‖I,t(i=0,1,…,r). In this note, we develop the methods of robust stability which is dependent on the size of some delays but independent on the size of the others and is based on the solution of linear matrix inequalities.

  12. Variable-delay feedback control of unstable steady states in retarded time-delayed systems

    Gjurchinovski, Aleksandar; 10.1103/PhysRevE.81.016209


    We study the stability of unstable steady states in scalar retarded time-delayed systems subjected to a variable-delay feedback control. The important aspect of such a control problem is that time-delayed systems are already infinite-dimensional before the delayed feedback control is turned on. When the frequency of the modulation is large compared to the system's dynamics, the analytic approach consists of relating the stability properties of the resulting variable-delay system with those of an analogous distributed delay system. Otherwise, the stability domains are obtained by a numerical integration of the linearized variable-delay system. The analysis shows that the control domains are significantly larger than those in the usual time-delayed feedback control, and that the complexity of the domain structure depends on the form and the frequency of the delay modulation.

  13. Fuzzy delay model based fault simulator for crosstalk delay fault test generation in asynchronous sequential circuits

    S Jayanthy; M C Bhuvaneswari


    In this paper, a fuzzy delay model based crosstalk delay fault simulator is proposed. As design trends move towards nanometer technologies, more number of new parameters affects the delay of the component. Fuzzy delay models are ideal for modelling the uncertainty found in the design and manufacturing steps. The fault simulator based on fuzzy delay detects unstable states, oscillations and non-confluence of settling states in asynchronous sequential circuits. The fuzzy delay model based fault simulator is used to validate the test patterns produced by Elitist Non-dominated sorting Genetic Algorithm (ENGA) based test generator, for detecting crosstalk delay faults in asynchronous sequential circuits. The multi-objective genetic algorithm, ENGA targets two objectives of maximizing fault coverage and minimizing number of transitions. Experimental results are tabulated for SIS benchmark circuits for three gate delay models, namely unit delay model, rise/fall delay model and fuzzy delay model. Experimental results indicate that test validation using fuzzy delay model is more accurate than unit delay model and rise/fall delay model.

  14. DELAYED FLOWERING, an Arabidopsis Gene That Acts in the Autonomous Flowering Promotion Pathway and Is Required for Normal Development

    Ming-Jie Chen; Zheng Yuan; Hai Huang


    The control of flowering time in higher plants is one of the most important physiological processes and is critical for their reproductive success. To investigate the mechanisms controlling flowering time, we screened for Arabidopsis mutants with late-flowering phenotypes. One mutant, designated delayed flowering (dfr) in the Landsberg erecta (Ler) ecotype, was identified with delayed flowering time. Genetic analysis revealed that dfr is a single gene recessive nuclear mutant and the mutation was mapped to a locus tightly linked to UFO on chromosome 1. To our knowledge, no gene regulating flowering time has been reported yet in this region. The dfr mutant plant showed a delayed flowering time under the different growth conditions examined,including long- and short-day photoperiods and gibberellic acid GA3 treatments, suggesting that DFR is a gene involved in the autonomous flowering promotion pathway. The Arabidopsis gene FLOWERING LOCUS C (FLC) plays a central role in repressing flowering and its transcripts are undetectable in wild-type Ler.However, FLCexpression was upregulated in the dfrmutant, suggesting that DFR is a negative regulator of FLC. In addition, the dfr mutant plant displayed altered valve shapes of the silique and the number of trichomes and branches of each trichome were both reduced, indicating that the DRFgene is also required for normal plant development. Moreover, dfr leafy-5 (Ify-5) double mutant plants showed a much later flowering time than either dfr or Ify-5 single mutants, indicating that DFR and LFYact synergistically to promote flowering in Arabidopsis.

  15. Delay discounting of food by rhesus monkeys: Cocaine and food choice in isomorphic and allomorphic situations.

    Huskinson, Sally L; Woolverton, William L; Green, Leonard; Myerson, Joel; Freeman, Kevin B


    Research on delay discounting has focused largely on nondrug reinforcers in an isomorphic context in which choice is between alternatives that involve the same type of reinforcer. Less often, delay discounting has been studied with drug reinforcers in a more ecologically valid allomorphic context where choice is between alternatives involving different types of reinforcers. The present experiment is the first to examine discounting of drug and nondrug reinforcers in both isomorphic and allomorphic situations using a theoretical model (i.e., the hyperbolic discounting function) that allows for comparisons of discounting rates between reinforcer types and amounts. The goal of the current experiment was to examine discounting of a delayed, nondrug reinforcer (food) by male rhesus monkeys when the immediate alternative was either food (isomorphic situation) or cocaine (allomorphic situation). In addition, we sought to determine whether there was a magnitude effect with delayed food in the allomorphic situation. Choice of immediate food and immediate cocaine increased with amount and dose, respectively. Choice functions for immediate food and cocaine generally shifted leftward as delay increased. Compared to isomorphic situations in which food was the immediate alternative, delayed food was discounted more steeply in allomorphic situations where cocaine was the immediate alternative. Notably, discounting was not affected by the magnitude of the delayed reinforcer. These data indicate that how steeply a delayed nondrug reinforcer is discounted may depend more on the qualitative characteristics of the immediate reinforcer and less on the magnitude of the delayed one.

  16. Delay Estimator and Improved Proportionate Multi-Delay Adaptive Filtering Algorithm

    E. Verteletskaya


    Full Text Available This paper pertains to speech and acoustic signal processing, and particularly to a determination of echo path delay and operation of echo cancellers. To cancel long echoes, the number of weights in a conventional adaptive filter must be large. The length of the adaptive filter will directly affect both the degree of accuracy and the convergence speed of the adaptation process. We present a new adaptive structure which is capable to deal with multiple dispersive echo paths. An adaptive filter according to the present invention includes means for storing an impulse response in a memory, the impulse response being indicative of the characteristics of a transmission line. It also includes a delay estimator for detecting ranges of samples within the impulse response having relatively large distribution of echo energy. These ranges of samples are being indicative of echoes on the transmission line. An adaptive filter has a plurality of weighted taps, each of the weighted taps having an associated tap weight value. A tap allocation/control circuit establishes the tap weight values in response to said detecting means so that only taps within the regions of relatively large distributions of echo energy are turned on. Thus, the convergence speed and the degree of estimation in the adaptation process can be improved.

  17. Additive and polynomial representations

    Krantz, David H; Suppes, Patrick


    Additive and Polynomial Representations deals with major representation theorems in which the qualitative structure is reflected as some polynomial function of one or more numerical functions defined on the basic entities. Examples are additive expressions of a single measure (such as the probability of disjoint events being the sum of their probabilities), and additive expressions of two measures (such as the logarithm of momentum being the sum of log mass and log velocity terms). The book describes the three basic procedures of fundamental measurement as the mathematical pivot, as the utiliz

  18. Transition delay using control theory.

    Bagheri, S; Henningson, D S


    This review gives an account of recent research efforts to use feedback control for the delay of laminar-turbulent transition in wall-bounded shear flows. The emphasis is on reducing the growth of small-amplitude disturbances in the boundary layer using numerical simulations and a linear control approach. Starting with the application of classical control theory to two-dimensional perturbations developing in spatially invariant flows, flow control based on control theory has progressed towards more realistic three-dimensional, spatially inhomogeneous flow configurations with localized sensing/actuation. The development of low-dimensional models of the Navier-Stokes equations has played a key role in this progress. Moreover, shortcomings and future challenges, as well as recent experimental advances in this multi-disciplinary field, are discussed.

  19. Does it pay to delay? Flesh flies show adaptive plasticity in reproductive timing.

    Wessels, Frank J; Kristal, Ross; Netter, Fleta; Hatle, John D; Hahn, Daniel A


    Life-history plasticity is widespread among organisms. However, an important question is whether it is adaptive. Most models for plasticity in life-history timing predict that animals, once they have reached the minimal nutritional threshold under poor conditions, will accelerate development or time to reproduction. Adaptive delays in reproduction are not common, especially in short-lived species. Examples of adaptive reproductive delays exist in mammalian populations experiencing strong interspecific (e.g., predation) and intraspecific (e.g., infanticide) competition. But are there other environmental factors that may trigger an adaptive delay in reproductive timing? We show that the short-lived flesh fly Sarcophaga crassipalpis will delay reproduction under nutrient-poor conditions, even though it has already met the minimal nutritional threshold for reproduction. We test whether this delay strategy is an adaptive response allowing the scavenger time to locate more resources by experimentally providing supplemental protein pulses (early, mid and late) throughout the reproductive delay period. Flies receiving additional protein produced more and larger eggs, demonstrating a benefit of the delay. In addition, by tracking the allocation of carbon from the pulses using stable isotopes, we show that flies receiving earlier pulses incorporated more carbon into eggs and somatic tissue than those given a later pulse. These results indicate that the reproductive delay in S. crassipalpis is consistent with adaptive post-threshold plasticity, a nutritionally linked reproductive strategy that has not been reported previously in an invertebrate species.

  20. Effects of Time Delay on the Bistable System Subjected to Correlated Noises

    NIE Lin-Ru; Mei Dong-Cheng


    The time-delayed bistable system subjected to the multiplicative and additive noises is investigated. In the condition of small delay time, the stationary probability distribution function (SPDF) is derived, and under the condition of large delay time, the SPDF is stochastically simulated. The analytical and simulative results indicate that: (i) For the case of λ= 0λ denotes the strength of correlations between the multiplicative and additive noises), the time delay affects weakly the SPDF peak structure, and the symmetrical property of the SPDF two-peak structure does not change with the increasing delay time, (ii) For the case of λ≠0, the two-peak structure changes with the increasing delay time, i.e. one peak goes up and the other go down simultaneously as the delay time increases and along with further increase of the delay time, the lower peak disappears gradually while the higher one goes up, i.e. the structure of the SPDF changes from a bimodal to a unimodal and the system becomes monostable.

  1. The range of time delay and the global stability of the equilibrium for an IVGTT model☆

    Li, Jiaxu; Wang, Minghu; De Gaetano, Andrea; Palumbo, Pasquale; Panunzi, Simona


    Diabetes mellitus has become a prevalent disease in the world. Diagnostic protocol for the onset of diabetes mellitus is the initial step in the treatments. The intravenous glucose tolerance test (IVGTT) has been considered as the most accurate method to determine the insulin sensitivity and glucose effectiveness. It is well known that there exists a time delay in insulin secretion stimulated by the elevated glucose concentration level. However, the range of the length of the delay in the existing IVGTT models are not fully discussed and thus in many cases the time delay may be assigned to a value out of its reasonable range. In addition, several attempts had been made to determine when the unique equilibrium point is globally asymptotically stable. However, all these conditions are delay-independent. In this paper, we discuss the range of the time delay and provide easy-to-check delay-dependent conditions for the global asymptotic stability of the equilibrium point for a recent IVGTT model through Liapunov function approach. Estimates of the upper bound of the delay for global stability are given in corollaries. In addition, the numerical simulation in this paper is fully incorporated with functional initial conditions, which is natural and more appropriate in delay differential equation system. PMID:22123436

  2. Dynamics of Nonlinear Time-Delay Systems

    Lakshmanan, Muthusamy


    Synchronization of chaotic systems, a patently nonlinear phenomenon, has emerged as a highly active interdisciplinary research topic at the interface of physics, biology, applied mathematics and engineering sciences. In this connection, time-delay systems described by delay differential equations have developed as particularly suitable tools for modeling specific dynamical systems. Indeed, time-delay is ubiquitous in many physical systems, for example due to finite switching speeds of amplifiers in electronic circuits, finite lengths of vehicles in traffic flows, finite signal propagation times in biological networks and circuits, and quite generally whenever memory effects are relevant. This monograph presents the basics of chaotic time-delay systems and their synchronization with an emphasis on the effects of time-delay feedback which give rise to new collective dynamics. Special attention is devoted to scalar chaotic/hyperchaotic time-delay systems, and some higher order models, occurring in different bran...

  3. Delay banking for air traffic management

    Green, Steven M. (Inventor)


    A method and associated system for time delay banking for aircraft arrival time, aircraft departure time and/or en route flight position. The delay credit value for a given flight may decrease with passage of time and may be transferred to or traded with other flights having the same or a different user (airline owner or operator). The delay credit value for a given aircraft flight depends upon an initial delay credit value, which is determined by a central system and depends upon one or more other flight characteristics. Optionally, the delay credit value decreases with passage of time. Optionally, a transaction cost is assessed against a delay credit value that is used on behalf of another flight with the same user or is traded with a different user.

  4. Memorized discrete systems and time-delay

    Luo, Albert C J


    This book examines discrete dynamical systems with memory—nonlinear systems that exist extensively in biological organisms and financial and economic organizations, and time-delay systems that can be discretized into the memorized, discrete dynamical systems. It book further discusses stability and bifurcations of time-delay dynamical systems that can be investigated through memorized dynamical systems as well as bifurcations of memorized nonlinear dynamical systems, discretization methods of time-delay systems, and periodic motions to chaos in nonlinear time-delay systems. The book helps readers find analytical solutions of MDS, change traditional perturbation analysis in time-delay systems, detect motion complexity and singularity in MDS; and determine stability, bifurcation, and chaos in any time-delay system.

  5. Phase changes in delay propagation networks

    Belkoura, Seddik


    The analysis of the dynamics of delays propagation is one of the major topics inside Air Transport Management research. Delays are generated by the elements of the system, but their propagation is a global process fostered by relationships inside the network. If the topology of such propagation process has been extensively studied in the literature, little attention has been devoted to the fact that such topology may have a dynamical nature. Here we differentiate between two phases of the system by applying two causality metrics, respectively describing the standard phase (i.e. propagation of normal delays) and a disrupted one (corresponding to abnormal and unexpected delays). We identify the critical point triggering the change of the topology of the system, in terms of delays magnitude, using a historical data set of flights crossing Europe in 2011. We anticipate that the proposed results will open new doors towards the understanding of the delay propagation dynamics and the mitigation of extreme events.

  6. A model for thin layer formation by delayed particle settling at sharp density gradients

    Prairie, Jennifer C.; White, Brian L.


    Thin layers - regions where plankton or particles accumulate vertically on scales of a few meters or less - are common in coastal waters, and have important implications for both trophic dynamics and carbon cycling. These features can form by a variety of biological and physical mechanisms, including localized growth, shear-thinning, and directed swimming. An additional mechanism may result in the formation of thin layers of marine aggregates, which have been shown to decrease their settling velocity when passing through sharp density gradients, a behavior termed delayed settling. Here, we apply a simple vertical advection-diffusion model to predict the properties of aggregate thin layers formed by this process. We assume a constant vertical flux of particles from the surface, which is parameterized by observations from laboratory experiments with marine aggregates. The formation, maintenance, and shape of the layers are described in relation to non-dimensional numbers that depend on environmental conditions and particle settling properties. In particular, model results demonstrate layer intensity and sharpness both increase with higher Péclet number (Pe), that is, under conditions with weaker mixing relative to layer formation. Similarly, more intense and sharper layers are found when the delayed settling behavior of aggregates is characterized by a lower velocity minimum. The model also predicts layers that are vertically asymmetric and highly "peaky" when compared with a Gaussian distribution, features often seen in thin layers in natural environments. Lastly, by comparing model predictions with observations of thin layers in the field, we are able to gain some insight into the applicability of delayed settling as a thin layer formation mechanism in different environmental conditions.

  7. Groups – Additive Notation

    Coghetto Roland


    Full Text Available We translate the articles covering group theory already available in the Mizar Mathematical Library from multiplicative into additive notation. We adapt the works of Wojciech A. Trybulec [41, 42, 43] and Artur Korniłowicz [25].

  8. Food Additives and Hyperkinesis

    Wender, Ester H.


    The hypothesis that food additives are causally associated with hyperkinesis and learning disabilities in children is reviewed, and available data are summarized. Available from: American Medical Association 535 North Dearborn Street Chicago, Illinois 60610. (JG)

  9. Prehospital delay in acute coronary syndrome--an analysis of the components of delay

    Ottesen, Michael Mundt; Dixen, Ulrik; Torp-Pedersen, Christian;


    more frequently atypical symptoms and increased prehospital delay caused by prolonged physician and transportation delay. Physician delay among women and men were 69 and 16 min, respectively. Patients with prior myocardial infarction had reduced prehospital delay, which was caused by shorter decision...... admitted with acute coronary syndrome is warranted. METHODS: A structured interview was conducted on 250 consecutive patients admitted alive with acute coronary syndrome. RESULTS: Median prehospital, decision, physician and transportation delays were 107, 74, 25 and 22 min, respectively. Women (n=77) had...... of acute coronary syndrome among women, and thereby contributes to unnecessary long delay to treatment. The patient's prior experience and interpretation has a significant influence on behaviour....

  10. Additively Manufactured Propulsion System

    Dushku, Matthew; Mueller, Paul


    New high-performance, carbon-fiber reinforced polymer material allows additive manufacturing to produce pressure vessels capable of high pressures (thousands of pounds per square inch). This advancement in turn allows integral hybrid propulsion which is revolutionary for both CubeSats and additively-manufactured spacecraft. Hybrid propulsion offers simplicity as compared to bipropellant liquid propulsion, significantly better safety compared to solid or monopropellant hydrazine propulsion, an...

  11. Delayed Operative Management of Fractures of the Lateral Condyle of the Humerus in Children

    Shabir AD


    Full Text Available Purpose; Delayed presentation of lateral condylar fractures of the humerus is relatively common in the developing regions of the world. These fractures are difficult to manage because of the displacement and fibrosis around the condylar fragment secondary to the delay. There is a paucity of literature concerning the management of these fractures. An oft repeated finding is the requirement of extensive dissection around the fragment for proper reduction. The purpose of this study was to assess the efficacy of surgical management of lateral condylar fractures with delayed presentation. Methods; We assessed the results of lateral condylar fracture fixation in 20 cases with delayed presentation. Results; The lateral condylar fractures in patients with a delayed presentation can be managed surgically with good results. Conclusions; Open reduction and internal fixation should continue to be the method of choice for the management of lateral condylar fractures which report late for management.

  12. Treatment of bronchial ruptures by delayed surgery


    Objective:To study the causes that resulted in delayed surgery for bronchial ruptures and the results.Methods:The cases with the bronchial ruptures by the delayed surgery last decade were retrospectively reviewed.The causes and unsatisfactory results were analysed.Results:The severe complications usually occurred after the delayed surgery and the results were not as satisfactory as those by early surgery.Conclusion:The bronchial ruptures ought to be operated in the early stage after being wounded.

  13. Time-delay and fractional derivatives

    Tenreiro Machado JA


    This paper proposes the calculation of fractional algorithms based on time-delay systems. The study starts by analyzing the memory properties of fractional operators and their relation with time delay. Based on the Fourier analysis an approximation of fractional derivatives through time-delayed samples is developed. Furthermore, the parameters of the proposed approximation are estimated by means of genetic algorithms. The results demonstrate the feasibility of the new perspective.

  14. Corrections and additions to a list of parasites for livestock and poultry in Guangxi Zhuang Autonomous Region%《广西壮族自治区畜禽寄生虫名录》补遗与修订(Ⅱ)

    张毅强; 黄维义


    本文是《广西壮族自治区畜禽寄生虫名录》的补遗与修订,收载了广西畜禽体内外寄生虫共计518种,隶属于7门,10纲,25目。它们包括:鞭毛虫2科,2属,2种;类锥体虫2科,4 属,46种;无类锥体虫2科,2属,4种;纤毛虫1科,1属,1种;吸虫16科,38属,95种;绦虫6科,24属,42种;线虫30科,65属,136种,棘头虫3科,3属,5种;蜱螨7科,13属,25 种;昆虫19科,38属,162种。%This paper is corrections and additions to “A list of parasites for livestock and po ultry in Guangxi Zhuang Autonomous Region”.Up to the present,a grand total of 5 18 species of parasites have been recorded.They belong to 25 orders,10 classes,7 phyla,which include:2 species,2 genera,2 families of mastigote;46 species,4 gen era,2 families of conoide;4 species,2 genera,2 families of aconoide;1 species,1 genus,1 family of cliliate;95 species,38 genera,16 families of tremat ode;42 species,24 genera,6 families of cestode;136 species,64 genera,30 familiea of nematode;5 species,3 genera,3 families of acanthocephalan;25 species,13 gene ra,7 families of arachnid;162 species,38 genera,19 families of insect.

  15. Characteristics of an Optical Delay Line for Radar Testing


    electrical devices, or allow unauthorized detection. In addition, integrity of the signals can be preserved travelling through long FODLs in...optical delay line, a commercial product from Miteq. The radar system parameters investigated were: small signal gain, 1 dB gain compression point...wide radio frequency (RF) bandwidth, low signal loss, compact and light weight, and highly resistant to electromagnetic interference. Fiber-based

  16. Reducing Transmitted Vibration Using Delayed Hysteretic Suspension

    Lahcen Mokni


    Full Text Available Previous numerical and experimental works show that time delay technique is efficient to reduce transmissibility of vibration in a single pneumatic chamber by controlling the pressure in the chamber. The present work develops an analytical study to demonstrate the effectiveness of such a technique in reducing transmitted vibrations. A quarter-car model is considered and delayed hysteretic suspension is introduced in the system. Analytical predictions based on perturbation analysis show that a delayed hysteretic suspension enhances vibration isolation comparing to the case where the nonlinear damping is delay-independent.

  17. Group Delay of High Q Antennas

    Bahramzy, Pevand; Pedersen, Gert Frølund


    become an issue, when working with high Q antennas, because of the steep phase shift over the frequency. In this paper, it is measured how large group delay variations can become, when going from a low Q antenna to a high Q antenna. The group delay of a low Q antenna is shown to be around 1.3 ns, whereas...... a high Q antenna has group delay of around 22 ns. It is due to this huge group delay variation characteristics of high Q antennas, that signal distortion might occur in the radio system with high Q antennas....

  18. Delay Computation Using Fuzzy Logic Approach

    Ramasesh G. R.


    Full Text Available The paper presents practical application of fuzzy sets and system theory in predicting delay, with reasonable accuracy, a wide range of factors pertaining to construction projects. In this paper we shall use fuzzy logic to predict delays on account of Delayed supplies and Labor shortage. It is observed that the project scheduling software use either deterministic method or probabilistic method for computation of schedule durations, delays, lags and other parameters. In other words, these methods use only quantitative inputs leaving-out the qualitative aspects associated with individual activity of work. The qualitative aspect viz., the expertise of the mason or the lack of experience can have a significant impact on the assessed duration. Such qualitative aspects do not find adequate representation in the Project Scheduling software. A realistic project is considered for which a PERT chart has been prepared using showing all the major activities in reasonable detail. This project has been periodically updated until its completion. It is observed that some of the activities are delayed due to extraneous factors resulting in the overall delay of the project. The software has the capability to calculate the overall delay through CPM (Critical Path Method when each of the activity-delays is reported. We shall now demonstrate that by using fuzzy logic, these delays could have been predicted well in advance.

  19. Angle-resolved time delay in photoemission

    Wätzel, Jonas; Pavlyukh, Yaroslav; Berakdar, Jamal


    We investigate theoretically the relative time delay of photoelectrons originating from different atomic subshells of noble gases. This quantity was measured via attosecond streaking and studied theoretically by Schultze et al. [Science 328, 1658 (2010)] for neon. A substantial discrepancy was found between the measured and the calculated values of the relative time delay. Several theoretical studies were put forward to resolve this issue, e.g., by including correlation effects. In the present paper we explore a further aspect, namely the directional dependence of time delay. In contrast to neon, for argon target a strong angular dependence of time delay is found near a Cooper minimum.

  20. Temperature Dependent Wire Delay Estimation in Floorplanning

    Winther, Andreas Thor; Liu, Wei; Nannarelli, Alberto;


    Due to large variations in temperature in VLSI circuits and the linear relationship between metal resistance and temperature, the delay through wires of the same length can be different. Traditional thermal aware floorplanning algorithms use wirelength to estimate delay and routability. In this w......Due to large variations in temperature in VLSI circuits and the linear relationship between metal resistance and temperature, the delay through wires of the same length can be different. Traditional thermal aware floorplanning algorithms use wirelength to estimate delay and routability...

  1. Stochastic Resonance in a Gene Transcriptional Regulatory System with Time Delay

    ZENG Chun-Hua; XIE Chong-Wei


    We study the stochastic resonance (SR) phenomenon in a time-delayed gene transcriptional regulatory system under the simultaneous action of a multiplicative noise and an additive noise and a weak periodic signal.The expression of the signal-to-noise ratio RSNR is obtained by applying the two-state theory in adiabatic limit under the condition of small delay time.The effects of delay time and intensity of the correlation between multiplicative and additive noise on RSNR are discussed.It is found that the delay time (T) enhances the SR of the system.The correlation intensity λ enhances the SR in the RSNR - D plot (D denotes the multiplicative noise intensity),but weakens the SR in the RSNR - α plot (α denotes the additive noise intensity).

  2. Delay-range-dependent chaos synchronization approach under varying time-lags and delayed nonlinear coupling.

    Zaheer, Muhammad Hamad; Rehan, Muhammad; Mustafa, Ghulam; Ashraf, Muhammad


    This paper proposes a novel state feedback delay-range-dependent control approach for chaos synchronization in coupled nonlinear time-delay systems. The coupling between two systems is esteemed to be nonlinear subject to time-lags. Time-varying nature of both the intrinsic and the coupling delays is incorporated to broad scope of the present study for a better-quality synchronization controller synthesis. Lyapunov-Krasovskii (LK) functional is employed to derive delay-range-dependent conditions that can be solved by means of the conventional linear matrix inequality (LMI)-tools. The resultant control approach for chaos synchronization of the master-slave time-delay systems considers non-zero lower bound of the intrinsic as well as the coupling time-delays. Further, the delay-dependent synchronization condition has been established as a special case of the proposed LK functional treatment. Furthermore, a delay-range-dependent condition, independent of the delay-rate, has been provided to address the situation when upper bound of the delay-derivative is unknown. A robust state feedback control methodology is formulated for synchronization of the time-delay chaotic networks against the L2 norm bounded perturbations by minimizing the L2 gain from the disturbance to the synchronization error. Numerical simulation results are provided for the time-delay chaotic networks to show effectiveness of the proposed delay-range-dependent chaos synchronization methodologies.

  3. Stability of Nonlinear Systems with Unknown Time-varying Feedback Delay

    Chunodkar, Apurva A.; Akella, Maruthi R.


    This paper considers the problem of stabilizing a class of nonlinear systems with unknown bounded delayed feedback wherein the time-varying delay is 1) piecewise constant 2) continuous with a bounded rate. We also consider application of these results to the stabilization of rigid-body attitude dynamics. In the first case, the time-delay in feedback is modeled specifically as a switch among an arbitrarily large set of unknown constant values with a known strict upper bound. The feedback is a linear function of the delayed states. In the case of linear systems with switched delay feedback, a new sufficiency condition for average dwell time result is presented using a complete type Lyapunov-Krasovskii (L-K) functional approach. Further, the corresponding switched system with nonlinear perturbations is proven to be exponentially stable inside a well characterized region of attraction for an appropriately chosen average dwell time. In the second case, the concept of the complete type L-K functional is extended to a class of nonlinear time-delay systems with unknown time-varying time-delay. This extension ensures stability robustness to time-delay in the control design for all values of time-delay less than the known upper bound. Model-transformation is used in order to partition the nonlinear system into a nominal linear part that is exponentially stable with a bounded perturbation. We obtain sufficient conditions which ensure exponential stability inside a region of attraction estimate. A constructive method to evaluate the sufficient conditions is presented together with comparison with the corresponding constant and piecewise constant delay. Numerical simulations are performed to illustrate the theoretical results of this paper.

  4. Time delay induced transition of gene switch and stochastic resonance in a genetic transcriptional regulatory model


    Background Noise, nonlinear interactions, positive and negative feedbacks within signaling pathways, time delays, protein oligomerization, and crosstalk between different pathways are main characters in the regulatory of gene expression. However, only a single noise source or only delay time in the deterministic model is considered in the gene transcriptional regulatory system in previous researches. The combined effects of correlated noise and time delays on the gene regulatory model still remain not to be fully understood. Results The roles of time delay on gene switch and stochastic resonance are systematically explored based on a famous gene transcriptional regulatory model subject to correlated noise. Two cases, including linear time delay appearing in the degradation process (case I) and nonlinear time delay appearing in the synthesis process (case II) are considered, respectively. For case I: Our theoretical results show that time delay can induce gene switch, i.e., the TF-A monomer concentration shifts from the high concentration state to the low concentration state ("on"→"off"). With increasing the time delay, the transition from "on" to "off" state can be further accelerated. Moreover, it is found that the stochastic resonance can be enhanced by both the time delay and correlated noise intensity. However, the additive noise original from the synthesis rate restrains the stochastic resonance. It is also very interesting that a resonance bi-peaks structure appears under large additive noise intensity. The theoretical results by using small-delay time-approximation approach are consistent well with our numerical simulation. For case II: Our numerical simulation results show that time delay can also induce the gene switch, however different with case I, the TF-A monomer concentration shifts from the low concentration state to the high concentration state ("off"→"on"). With increasing time delay, the transition from "on" to "off" state can be further

  5. Delayed ventricular repolarization as an anti-arrhythmic principle.

    Vaughan Williams, E M


    Depolarization of cardiac muscle is achieved by 'fast inward current' through channels which are inactivated within about 1 ms. When the cells are repolarized the process of inactivation of fast channels is rapidly reversed. The class 1 anti-arrhythmic drugs delay the disappearance of inactivation until long after repolarization is complete. In theory, it should be possible to produce a similar extension of refractory period by delaying the repolarization itself. Quinidine and disopyramide caused minor delays of repolarization, but both were primarily class 1 agents, and in addition had undesirable anticholinergic activity. Amiodarone, already in use for many years as an antianginal drug, prolonged action potential duration (APD) and was shown to have an anti-arrhythmic action in rabbits, dogs and man. Although prolongation of APD lengthens QT, a long QT may be caused by phenomena other than prolonged APD, such as heterogeneity of sympathetic drive. Association of long QT with arrhythmia does not, therefore, invalidate the principle that homogeneously prolonged APD should be anti-arrhythmic. In practice, amiodarone, bretylium, sotalol, thyroidectomy, and long-term beta-blockade prolong APD, and are associated with low incidence of arrhythmia. Many mechanisms controlling cardiac repolarization have been proposed, but how repolarization is delayed by individual agents is not fully elucidated.

  6. A Novel Message Scheduling Framework for Delay Tolerant Networks Routing

    Elwhishi, Ahmed


    Multicopy routing strategies have been considered the most applicable approaches to achieve message delivery in Delay Tolerant Networks (DTNs). Epidemic routing and two-hop forwarding routing are two well-reported approaches for delay tolerant networks routing which allow multiple message replicas to be launched in order to increase message delivery ratio and/or reduce message delivery delay. This advantage, nonetheless, is at the expense of additional buffer space and bandwidth overhead. Thus, to achieve efficient utilization of network resources, it is important to come up with an effective message scheduling strategy to determine which messages should be forwarded and which should be dropped in case of buffer is full. This paper investigates a new message scheduling framework for epidemic and two-hop forwarding routing in DTNs, such that the forwarding/dropping decision can be made at a node during each contact for either optimal message delivery ratio or message delivery delay. Extensive simulation results show that the proposed message scheduling framework can achieve better performance than its counterparts.

  7. Protocol for a Delay-Tolerant Data-Communication Network

    Torgerson, Jordan; Hooke, Adrian; Burleigh, Scott; Fall, Kevin


    As its name partly indicates, the Delay-Tolerant Networking (DTN) Bundle Protocol is a protocol for delay-tolerant transmission of data via communication networks. This protocol was conceived as a result of studies of how to adapt Internet protocols so that Internet-like services could be provided across interplanetary distances in support of deep-space exploration. The protocol, and software to implement the protocol, is being developed in collaboration among experts at NASA's Jet Propulsion Laboratory and other institutions. No current Internet protocols can accommodate long transmission delay times or intermittent link connectivity. The DTN Bundle Protocol represents a departure from the standard Internet assumption that a continuous path is available from a host computer to a client computer: It provides for routing of data through networks that may be disjointed and may be characterized by long transmission delays. In addition to networks that include deepspace communication links, examples of such networks include terrestrial ones within which branches are temporarily disconnected. The protocol is based partly on the definition of a message-based overlay above the transport layers of the networks on which it is hosted.

  8. A stochastically forced time delay solar dynamo model: Self-consistent recovery from a maunder-like grand minimum necessitates a mean-field alpha effect

    Hazra, Soumitra; Nandy, Dibyendu [Department of Physical Sciences, Indian Institute of Science Education and Research, Kolkata, West Bengal (India); Passos, Dário, E-mail:, E-mail:, E-mail: [CENTRA-IST, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa (Portugal)


    Fluctuations in the Sun's magnetic activity, including episodes of grand minima such as the Maunder minimum have important consequences for space and planetary environments. However, the underlying dynamics of such extreme fluctuations remain ill-understood. Here, we use a novel mathematical model based on stochastically forced, non-linear delay differential equations to study solar cycle fluctuations in which time delays capture the physics of magnetic flux transport between spatially segregated dynamo source regions in the solar interior. Using this model, we explicitly demonstrate that the Babcock-Leighton poloidal field source based on dispersal of tilted bipolar sunspot flux, alone, cannot recover the sunspot cycle from a grand minimum. We find that an additional poloidal field source effective on weak fields—e.g., the mean-field α effect driven by helical turbulence—is necessary for self-consistent recovery of the sunspot cycle from grand minima episodes.

  9. On the control of bistability in non-contact mode AFM using modulated time delay

    Kirrou I.


    Full Text Available We study the control of bistability in non-contact mode AFM using time delay with modulated feedback gain. We consider that the tip-sample interaction force is described by Lennard-Jones potential and the equation of motion is modeled by single degree of freedom system. Perturbation analysis is performed to obtain the modulation equations of the slow dynamic. The influence of the modulated time delay on the nonlinear characteristic of the frequency response is analyzed and the evolution of the bistability region in the modulated time delay parameter plan is examined. Results show that modulation of the feedback gain can be used to reduce the amplitude of the microcanteliver response and to suppress the bistability regime in large region of the modulated delay parameter space. The analytical predictions are compared to numerical simulations for validation.

  10. Anomalous transports in a time-delayed system subjected to anomalous diffusion

    Chen, Ru-Yin; Tong, Lu-Mei; Nie, Lin-Ru; Wang, Chaojie; Pan, Wanli


    We investigate anomalous transports of an inertial Brownian particle in a time-delayed periodic potential subjected to an external time-periodic force, a constant bias force, and the Lévy noise. By means of numerical calculations, effect of the time delay and the Lévy noise on its mean velocity are discussed. The results indicate that: (i) The time delay can induce both multiple current reversals (CRs) and absolute negative mobility (ANM) phenomena in the system; (ii) The CRs and ANM phenomena only take place in the region of superdiffusion, while disappear in the regions of normal diffusion; (iii) The time delay can cause state transition of the system from anomalous →normal →anomalous →normal →anomalous →normal transport in the case of superdiffusion.

  11. Additives for the Axe


    On May 1,China will begin to ban the production and use of two food additives commonly used to "bleach" flour,benzoyl peroxide and calcium peroxide.The decision was made after 10 years of wrangling between the policy makers,manufacturers,scientists and consumers.The Ministry of Health said in a statement it was applying the ban in response to consumers’ concerns about chemical substances in food,and technical improvements that had made the two additives unnecessary in flour processing.Minister of Health Chen Zhu has also said

  12. Alternative additives; Alternative additiver


    In this project a number of industrial and agricultural waste products have been characterised and evaluated in terms of alkali-getter performance. The intended use is for biomass-fired power stations aiming at reducing corrosion or slagging related problems. The following products have been obtained, characterised and evaluated: 1) Brewery draff 2) Danish de-gassed manure 3) Paper sludge 4) Moulding sand 5) Spent bleaching earth 6) Anorthosite 7) Sand 8) Clay-sludge. Most of the above alternative additive candidates are deemed unsuitable due to insufficient chemical effect and/or expensive requirements for pre-treatment (such as drying and transportation). 3 products were selected for full-scale testing: de-gassed manure, spent bleaching earth and clay slugde. The full scale tests were undertaken at the biomass-fired power stations in Koege, Slagelse and Ensted. Spent bleaching earth (SBE) and clay sludge were the only tested additive candidates that had a proven ability to react with KCl, to thereby reduce Cl-concentrations in deposits, and reduce the deposit flux to superheater tubes. Their performance was shown to nearly as good as commercial additives. De-gassed manure, however, did not evaluate positively due to inhibiting effects of Ca in the manure. Furthermore, de-gassed manure has a high concentration of heavy metals, which imposes a financial burden with regard to proper disposal of the ash by-products. Clay-sludge is a wet clay slurring, and drying and transportation of this product entails substantial costs. Spent bleaching does not require much pre-treatment and is therefore the most promising alternative additive. On the other hand, bleaching earth contains residual plant oil which means that a range of legislation relating to waste combustion comes into play. Not least a waste combustion fee of 330 DKK/tonne. For all alternative (and commercial) additives disposal costs of the increase ash by-products represents a significant cost. This is

  13. From additivity to synergism

    Ritz, Christian; Streibig, Jens Carl


    Interest in synergistic or antagonistic effects through mixture experiments has grown immensely over the past two decades, not the least within in pharmacology and toxicology. Several definitions of reference models exist; one commonly used reference model is concentration or dose addition, which...... assumes compounds, when administrated simultaneously, do not interfere with each other at the site of action. We focus on statistical modelling that allows evaluation of dose addition. We will describe several statistical approaches that are suitable for analysis mixture data where synergistic...... or antagonistic effects may be present. The statistical models are defined and explained and some of the approaches exemplified. Code in open-source software is provided....

  14. Noise transmission and delay-induced stochasticoscillations in biochemical network motifs

    Liu Sheng-Jun; Wang Qi; Liu Bo; Yan Shi-Wei; Fumihiko Sakata


    With the aid of stochastic delayed-feedback differential equations,we derive an analytic expression for the power spectra of reacting molecules included in a generic biological network motif that is incorporated with a feedback mechanism and time delays in gene regulation.We systematically analyse the effects of time delays,the feedback mechanism,and biological stochasticity on the power spectra.It has been clarified that the time delays together with the feedback mechanism can induce stochastic oscillations at the molecular level and invalidate the noise addition rule for a modular description of the noise propagator.Delay-induced stochastic resonance can be expected,which is related to the stability loss of the reaction systems and Hopf bifurcation occurring for solutions of the corresponding deterministic reaction equations.Through the analysis of the power spectrum,a new approach is proposed to estimate the oscillation period.

  15. Delay analysis of a satellite channel reservation system with variable frame format

    Mine, H.; Ohno, K.; Shioyama, T.


    In describing the operation, it is pointed out that the current queue length at each user is reported through minislots in the up-link header to a satellite possessing processing capability. The satellite broadcasts slot assignments for transmission in the next frame to users through the down-link header on the basis of the users' reported queue status. The number of data slots per frame varies according to the reported queue status of the users. A Markov-chain model is presented for analyzing the average total delay of the system. Numerical results are given for comparing the delay of the system with the delay of TDMA and reservation systems with fixed frame format. The system is shown to provide a better delay/throughput performance than these other systems over a wide range of traffic intensities. In addition, the delay curve of the system is relatively flat up to a traffic intensity of approximately 0.8.

  16. Influence analysis of time delay to active mass damper control system using pole assignment method

    Teng, J.; Xing, H. B.; Lu, W.; Li, Z. H.; Chen, C. J.


    To reduce the influence of time delay on the Active Mass Damper (AMD) control systems, influence analysis of time delay on system poles and stability is applied in the paper. A formula of the maximum time delay for ensuring system stability is established, by which the influence analysis of control gains on system stability is further arisen. In addition, the compensation controller is designed based on the given analysis results and pole assignment. A numerical example and an experiment are illustrated to verify that the performance of time-delay system. The result is consistent to that of the long-time delay control system, as well as to proof the better effectiveness of the new method proposed in this article.

  17. Stability criteria for linear systems with multiple time-varying delays

    Bugong XU


    New delay-independent and delay-dependent stability criteria for linear systems with multiple time-varying delays are established by using the me-domain method. The results are derived based on a new-type stability theorem for general retarded dynamical systems and new analysis techniques developed in the author's previous work. Unlike some results in the literature, all of the established results do not depend on the derivative of time-varying delays. Therefore, they are suitable for the case with very fast me-varying delays. In addition, some remarks are also given to explain the obtained results and to point out the limitations of the previous results in the literature.

  18. Delay-dependent state feedback robust stabilization for uncertain singular time-delay systems

    Gao Huanli; Xu Bugong


    The problem of robust stabilization for uncertain singular time-delay systems is studied.First,a new delay-dependent asymptotic stability criteria for normal singular time-delay systems is given,which is less conservative.Using this result,the problem of state feedback robust stabilization for uncertain singular time-delay systems is discussed.Finally,two examples are given to illustrate the effectiveness of the results.

  19. Delay-dependent robust passivity control for uncertain time-delay systems

    Li Guifang; Li Huiying; Yang Chengwu


    The robust passivity control problem is addressed for a class of uncertain delayed systems with timevarying delay. The parameter uncertainties are norm-bounded. First, the delay-dependent stability sufficient condition is obtained for the nominal system, and then, based-on the former, the delay-dependent robust passivity criteria is provided and the corresponding controller is designed in terms of linear matrix inequalities. Finally, a numerical example is given to demonstrate the validity of the proposed approach.

  20. Goos-Haenchen shift and time delay in dispersive nonlinear media

    Ilic, I. [Vinca Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, 11001 Belgrade (Serbia); Belicev, P.P., E-mail: petrab@vinca.r [Vinca Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, 11001 Belgrade (Serbia); Milanovic, V.; Radovanovic, J. [Faculty of Electrical Engineering, University of Belgrade, Bul. kralja Aleksandra 73, 11120 Belgrade (Serbia); Hadzievski, Lj. [Vinca Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, 11001 Belgrade (Serbia)


    We present an analysis of the influence of the Goos-Haenchen effect on tunneling times, group delay and dwell time, of electromagnetic waves propagating through an obstacle made of left-handed metamaterial embedded in a dielectric which exhibits saturable type of nonlinearity. The derived equations show that only the group delay, is affected by the Goos-Haenchen shift without any impact on the dwell time. Besides the reduction of the group delay, the most remarkable result is the possibility for total reduction of the Goos-Haenchen shift for finite incident angles. These phenomena are observable in the frequency region for which metamaterial exhibits negative index of refraction.

  1. Synchronization of unidirectional time delay chaotic networks and the greatest common divisor

    Kanter, I; Englert, A; Geissler, F; Kinzel, W; 10.1209/0295-5075/93/60003


    We present the interplay between synchronization of unidirectional coupled chaotic nodes with heterogeneous delays and the greatest common divisor (GCD) of loops composing the oriented graph. In the weak chaos region and for GCD=1 the network is in chaotic zero-lag synchronization, whereas for GCD=m>1 synchronization of m-sublattices emerges. Complete synchronization can be achieved when all chaotic nodes are influenced by an identical set of delays and in particular for the limiting case of homogeneous delays. Results are supported by simulations of chaotic systems, self-consistent and mixing arguments, as well as analytical solutions of Bernoulli maps.

  2. Synchronization of unidirectional time delay chaotic networks and the greatest common divisor

    Kanter, I.; Zigzag, M.; Englert, A.; Geissler, F.; Kinzel, W.


    We present the interplay between synchronization of unidirectional coupled chaotic nodes with heterogeneous delays and the greatest common divisor (GCD) of loops composing the oriented graph. In the weak-chaos region and for GCD=1 the network is in chaotic zero-lag synchronization, whereas for GCD=m>1 synchronization of m-sublattices emerges. Complete synchronization can be achieved when all chaotic nodes are influenced by an identical set of delays and in particular for the limiting case of homogeneous delays. Results are supported by simulations of chaotic systems, self-consistent and mixing arguments, as well as analytical solutions of Bernoulli maps.

  3. Biobased lubricant additives

    Fully biobased lubricants are those formulated using all biobased ingredients, i.e. biobased base oils and biobased additives. Such formulations provide the maximum environmental, safety, and economic benefits expected from a biobased product. Currently, there are a number of biobased base oils that...

  4. Longer pre-hospital delay in acute myocardial infarction in women because of longer doctor decision time

    Bouma, J; Broer, J; Bleeker, J; van Sonderen, E; Meyboom-de Jong, B; DeJongste, MJL


    Study objective-To measure the prehospital delay times in patients with proven acute myocardial infarction (AMI) and to identify possibilities for reduction of treatment delay. Design-Descriptive three centre study. Setting-One university teaching hospital and two regional hospitals in Groningen, th

  5. Effects of Time Delay on Stability of an Unstable State in a Bistable System with Correlated Noises

    LI Chun; MEI Dong-Cheng


    @@ Effects of time delay on stability of an unstable state in a time-delayed bistable system are investigated.The analytic expression of the transition rate W(xu,τ)from unstable state xu to stable state x+ is derived.The numerical calculation results of W(xu,τ)indicate that W(xu,τ)decreases with the increasing multiplicative noise intensity, the additive noise intensi by and the strength of correlations between the multiplicative and the additive noise increase, but W(xu,τ)increases with increasing delay time.Namely, the multiplicative noise, the additive noise and the correlations between the multiplicative and the additive noises enhance the stability of the unstable state in the time-delayed bistable system but the stability is weakened by time delay.%Effects of time delay on stability of an unstable state in a time-delayed bistable system are investigated. The analytic expression of the transition rate W(xu, T) from unstable state xu to stable state x+ is derived. The numerical calculation results of W(xu, T) indicate that W(xu, T) decreases with the increasing multiplicative noise intensity, the additive noise intensity and the strength of correlations between the multiplicative and the additive noise increase, but W(xu, T) increases with increasing delay time. Namely, the multiplicative noise, the additive noise and the correlations between the multiplicative and the additive noises enhance the stability of the unstable state in the time-delayed bistable system but the stability is weakened by time delay.

  6. Factors in delayed muscle soreness.

    Abraham, W M


    The possible causes of delayed muscle soreness which occur 24 to 48 hr after exercise were examined from three different approaches, each designed to test an existing hypothesis. Surface electromyograms were used to evaluate the muscle spasm theory; the possibility of actual muscle cell damage was monitored by the presence of myoglobinuria, while the ratio of hydroxyproline/creatinine (OHP/Cr) in 24 hr urine collection was used as a marker for connective tissue involvement. In the first study, although all volunteers developed muscle soreness 24 and 48 hr after exercise, no change in the EMG activity of the sore muscles was observed. Myoglobin excretion was found in 88% of the subjects who developed soreness. However, in a second study, 92% of the subject who performed both moderate and heavy exercise but did not develop muscle soreness had myoglobinuria. In contrast, during a third experiment subjects on gelatin-free diets showed an increase (P less than .1) in the OHP/Cr between control (.020+/-.001) and 48 hr post-exercise (.002+/-.001, X+/-SE). Soreness resulted in all cases. When the OHP/Cr value is taken for the day of maximal soreness, the post-exercise mean increases to .024+/-.001 and the level of significance rises (P less than .005). These observations support the concept that exercise induced soreness may be related to disruption of the connective tissue elements in the muscle and/or their attachments.

  7. Improved delay-dependent exponential stability for uncertain stochastic neural networks with time-varying delays

    Kwon, O.M., E-mail: [School of Electrical Engineering, Chungbuk National University, Cheongju (Korea, Republic of); Lee, S.M., E-mail: [School of Electronics Engineering, Daegu University, Kyongsan (Korea, Republic of); Park, Ju H., E-mail: [Department of Electrical Engineering, Yeungnam University, Kyongsan (Korea, Republic of)


    This Letter investigates the problem of delay-dependent exponential stability analysis for uncertain stochastic neural networks with time-varying delay. Based on the Lyapunov stability theory, improved delay-dependent exponential stability criteria for the networks are established in terms of linear matrix inequalities (LMIs).

  8. Stabilization of a Nonlinear Delay System

    Walid Arouri


    Full Text Available Problem statement: The analysis and control of delayed systems are becoming more and more research topics in progress. This is mainly due to the fact that the delay is frequently encountered in technological systems. This can affect their significantly operations. Most control command laws are based on current digital computers and delays are intrinsic to the process or in the control loop caused by the transmission time control sequences, or computing time. The delay may affect one or more states of the considered system. It may also affect the establishment of the command. Several studies have investigated the stability of delay systems under the assumption that the delay is a variable phenomenon; such variation is considered to be bounded or limited to facilitate analysis of the system. In this study we propose a modelling of delayed system by using the multimodels and switched system theory. The analysis of stability is based on the use of second Lyapunov method. The issued stability conditions are expressed as Bilinear Matrix Inequalities impossible to resolve. That’s why we propose the same original relaxations to come over this difficulty, an example of induction machine is given to illustrate over approach. Approach: We propose to use the control theory developed for switched systems to synthesis a control laws for the stabilisation of delays system. Results: We stabilize the induction machine around many operating points despite the non linearities. Conclusion: The developed method is less conservative and less pessimistic than the used classical methods.

  9. Delayed biodiversity change: no time to waste.

    Essl, Franz; Dullinger, Stefan; Rabitsch, Wolfgang; Hulme, Philip E; Pyšek, Petr; Wilson, John R U; Richardson, David M


    Delayed biodiversity responses to environmental forcing mean that rates of contemporary biodiversity changes are underestimated, yet these delays are rarely addressed in conservation policies. Here, we identify mechanisms that lead to such time lags, discuss shifting human perceptions, and propose how these phenomena should be addressed in biodiversity management and science.

  10. Delay synchronization of temporal Boolean networks

    Wei, Qiang; Xie, Cheng-jun; Liang, Yi; Niu, Yu-jun; Lin, Da


    This paper investigates the delay synchronization between two temporal Boolean networks base on semi-tensor product method, which improve complete synchronization. Necessary and sufficient conditions for delay synchronization are drawn base on algebraic expression of temporal Boolean networks. A example is presented to show the effectiveness of theoretical analysis.

  11. [Delayed asthma bronchiale due to epoxy resin].

    Authried, Georg; Al-Asadi, Haifaa; Møller, Ulla; Sherson, David Lee


    Epoxy resin is a low molecular weight agent, which can cause both acute and delayed allergic reactions. However, it is known causing skin reactions with direct or airborne contact. Rarely it can cause airway reactions like asthma bronchiale. We describe a case of a windmill worker who developed delayed asthma bronchiale due to airborne contact with epoxy resin.

  12. Test Anxiety and Academic Delay of Gratification

    Bembenutty, Hefer


    The present study examined the relationship between college students' willingness to delay gratification, motivation, self-regulation of learning, and their level of test anxiety (N = 364). Academic delay of gratification refers to students' postponement of immediately available opportunities to satisfy impulses in favor of pursuing academic…

  13. Diagnostic Delay in Women with Endometriosis

    Xiao-man Ding; Jing-he Lang


    @@ Women affected by endometriosis claim that delayed diagnosis of endometriosis is a great problem. Studies have shown a delay from 3 to 11 years between the onset of pain symptom and the final diagnosis of endometriosis. But the diagnostic time of Chinese patients has not been reported.

  14. Controllability of delay systems with restrained controls

    Chukwu, E. N.


    Using a geometric growth condition, both the function space and Euclidean controllability of a nonlinear delay system which has a compact and convex control set are characterized. This extends analogous results for ordinary differential systems, and it yields conditions under which perturbed nonlinear delay controllable systems are controllable.

  15. Estimating Time Delays With Antenna Array


    This paper discusses the problem of estimating the time delays of multipath signals in wireless communications. The new multipath channel model is presented. And based on this new channel model, we generalize the classical MUSIC algorithm to estimate the time delays of multipath signals. Simulation examples are included to illustrate the algorithm performance.

  16. Comment on "Time delays in molecular photoionization"

    Baykusheva, D


    In a recent article by P. Hockett \\textit{et al.}, time delays arising in the context of molecular single-photon ionization are investigated from a theoretical point of view. We argue that one of the central equations derived in the paper is incorrect and present a reformulation that is consistent with the established treatment of angle-dependent scattering delays.

  17. Broadband hyperchaotic oscillator with delay line

    Cenys, Antanas; Lindberg, Erik; Anagnostopoulos, A. N.;


    Dynamical systems with time delay can be employed as high dimensional hyperchaotic oscillators with multiple positive Lyapunov exponents. We describe an electronic circuit composed of a 3-stage amplifier and a delay line in the feedback loop. The 1st stage of the amplifier is a nonlinear one while...

  18. Space object tracking with delayed measurements

    Chen, Huimin; Shen, Dan; Chen, Genshe; Blasch, Erik; Pham, Khanh


    This paper is concerned with the nonlinear filtering problem for tracking a space object with possibly delayed measurements. In a distributed dynamic sensing environment, due to limited communication bandwidth and long distances between the earth and the satellites, it is possible for sensor reports to be delayed when the tracking filter receives them. Such delays can be complete (the full observation vector is delayed) or partial (part of the observation vector is delayed), and with deterministic or random time lag. We propose an approximate approach to incorporate delayed measurements without reprocessing the old measurements at the tracking filter. We describe the optimal and suboptimal algorithms for filter update with delayed measurements in an orbital trajectory estimation problem without clutter. Then we extend the work to a single object tracking under clutter where probabilistic data association filter (PDAF) is used to replace the recursive linear minimum means square error (LMMSE) filter and delayed measurements with arbitrary lags are be handled without reprocessing the old measurements. Finally, we demonstrate the proposed algorithms in realistic space object tracking scenarios using the NASA General Mission Analysis Tool (GMAT).

  19. On Delay and Security in Network Coding

    Dikaliotis, Theodoros K.


    In this thesis, delay and security issues in network coding are considered. First, we study the delay incurred in the transmission of a fixed number of packets through acyclic networks comprised of erasure links. The two transmission schemes studied are routing with hop-by-hop retransmissions, where every node in the network simply stores and…

  20. Congenital rubella syndrome and delayed manifestations

    Dammeyer, Jesper Herup


    Objective: Several hypotheses of different medical and psychological delayed manifestations among people who have congenital rubella syndrome (CRS) have been discussed. This study tests some of these hypotheses of delayed manifestations. Methods: Gathering information about 35 individuals who hav...... which people with CRS face must primarily be understood in relation to congenital deafblindness and dual sensory and communicative deprivation....

  1. Discounting of Delayed Rewards Is Not Hyperbolic

    Luhmann, Christian C.


    Delay discounting refers to decision-makers' tendency to value immediately available goods more than identical goods available only after some delay. In violation of standard economic theory, decision-makers frequently exhibit dynamic inconsistency; their preferences change simply due to the passage of time. The standard explanation for this…

  2. Multiple THz pulse generation with variable energy ratio and delay

    Ungureanu, R. G.; Grigore, O. V.; Dinca, M. P.; Cojocaru, G. V.; Ursescu, D.; Dascalu, T.


    Two methods for multiple high energetic THz pulse generation by two-color filamentation in air with controllable energy ratio and delay ranging from one to hundreds of ps were investigated. In the first method the laser pulse is split into two inside the optical stretcher of a CPA laser system, the resulting consecutive filaments occur in the same region and allows the study of the influence of the first plasma filament on the THz emission of the delayed filament. Based on a polarization sensitive thin film beam splitter placed in front of a 45° mirror, the second method produces multiple parallel consecutive filaments. Above a certain total pump level the THz energy delivered by multiple pulses exceeds the value given by a single filament for the same pump energy, thereby overcoming the THz emission saturation of the single filament.

  3. Photonic Quantum Circuits with Time Delays

    Pichler, Hannes


    We study the dynamics of photonic quantum circuits consisting of nodes coupled by quantum channels. We are interested in the regime where time delay in communication between the nodes is significant. This includes the problem of quantum feedback, where a quantum signal is fed back on a system with a time delay. We develop a matrix product state approach to solve the Quantum Stochastic Schr\\"odinger Equation with time delays, which accounts in an efficient way for the entanglement of nodes with the stream of emitted photons in the waveguide, and thus the non-Markovian character of the dynamics. We illustrate this approach with two paradigmatic quantum optical examples: two coherently driven distant atoms coupled to a photonic waveguide with a time delay, and a driven atom coupled to its own output field with a time delay as an instance of a quantum feedback problem.

  4. Ice Formation Delay on Penguin Feathers

    Alizadehbirjandi, Elaheh; Tavakoli-Dastjerdi, Faryar; St. Leger, Judy; Davis, Stephen H.; Rothstein, Jonathan P.; Kavehpour, H. Pirouz


    Antarctic penguins reside in a harsh environment where air temperature may reach -40 °C with wind speed of 40 m/s and water temperature remains around -2.2 °C. Penguins are constantly in and out of the water and splashed by waves, yet even in sub-freezing conditions, the formation of macroscopic ice is not observed on their feathers. Bird feathers are naturally hydrophobic; however, penguins have an additional hydrophobic coating on their feathers to reinforce their non-wetting properties. This coating consists of preen oil which is applied to the feathers from the gland near the base of the tail. The combination of the feather's hydrophobicity and surface texture is known to increase the contact angle of water drops on penguin feathers to over 140 ° and classify them as superhydrophobic. We here develop an in-depth analysis of ice formation mechanism on superhydrophobic surfaces through careful experimentations and development of a theory to address how ice formation is delayed on these surfaces. Furthermore, we investigate the anti-icing properties of warm and cold weather penguins with and without preen oil to further design a surface minimizing the frost formation which is of practical interest especially in aircraft industry.

  5. Smart Toys Designed for Detecting Developmental Delays

    Diego Rivera


    Full Text Available In this paper, we describe the design considerations and implementation of a smart toy system, a technology for supporting the automatic recording and analysis for detecting developmental delays recognition when children play using the smart toy. To achieve this goal, we take advantage of the current commercial sensor features (reliability, low consumption, easy integration, etc. to develop a series of sensor-based low-cost devices. Specifically, our prototype system consists of a tower of cubes augmented with wireless sensing capabilities and a mobile computing platform that collect the information sent from the cubes allowing the later analysis by childhood development professionals in order to verify a normal behaviour or to detect a potential disorder. This paper presents the requirements of the toy and discusses our choices in toy design, technology used, selected sensors, process to gather data from the sensors and generate information that will help in the decision-making and communication of the information to the collector system. In addition, we also describe the play activities the system supports.

  6. Smart Toys Designed for Detecting Developmental Delays

    Rivera, Diego; García, Antonio; Alarcos, Bernardo; Velasco, Juan R.; Ortega, José Eugenio; Martínez-Yelmo, Isaías


    In this paper, we describe the design considerations and implementation of a smart toy system, a technology for supporting the automatic recording and analysis for detecting developmental delays recognition when children play using the smart toy. To achieve this goal, we take advantage of the current commercial sensor features (reliability, low consumption, easy integration, etc.) to develop a series of sensor-based low-cost devices. Specifically, our prototype system consists of a tower of cubes augmented with wireless sensing capabilities and a mobile computing platform that collect the information sent from the cubes allowing the later analysis by childhood development professionals in order to verify a normal behaviour or to detect a potential disorder. This paper presents the requirements of the toy and discusses our choices in toy design, technology used, selected sensors, process to gather data from the sensors and generate information that will help in the decision-making and communication of the information to the collector system. In addition, we also describe the play activities the system supports. PMID:27879626

  7. Delayed gait recovery in a stroke patient

    Jeong Pyo Seo; Mi Young Lee; Yong Hyun Kwon; Sung Ho Jang


    We report on a stroke patient who showed delayed gait recovery between 8 and 11 months after the onset of intracerebral hemorrhage. This 32-year-old female patient underwent craniotomy and drainage for right intracerebral hemorrhage due to rupture of an arteriovenous malformation. Brain MR images revealed a large leukomalactic lesion in the right fronto-parietal cortex. Diffusion tensor tractography at 8 months after onset revealed that the right corticospinal tract was severely injured. At this time, the patient could not stand or walk despite undergoing rehabilitation from 2 months after onset. It was believed that severe spasticity of the left leg and right ankle was largely responsible, and thus, antispastic drugs, antispastic procedures (alcohol neurolysis of the motor branch of the tibial nerve and an intramuscular alcohol wash of both tibialis posterior muscles) and physical therapy were tried to control the spasticity. These measures relieved the severe spasticity, with the result that the patient was able to stand at 3 months. In addition, the improvements in sensorimotor function, visuospatial function, and cognition also seemed to contribute to gait recovery. As a result, she gained the ability to walk independently on even floor with a left ankle foot orthosis at 11 months after onset. This case illustrates that clinicians should attempt to find the months after onset.

  8. Advances in Additive Manufacturing


    burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching ...Society for Machinery Failure Prevention Technology conference in Dayton, OH, on 23–26 May 2016. These 6 briefs were presented in the Additive...manufacturing (AM) at the 2016 conference in Dayton, Ohio, on May 24th, 2016. The presentations included work being performed within the Department of Defense

  9. The role of time delay in adaptive cellular negative feedback systems.

    Lapytsko, Anastasiya; Schaber, Jörg


    Adaptation in cellular systems is often mediated by negative feedbacks, which usually come with certain time delays causing several characteristic response patterns including an overdamped response, damped or sustained oscillations. Here, we analyse generic two-dimensional delay differential equations with delayed negative feedback describing the dynamics of biochemical adaptive signal-response networks. We derive explicit thresholds and boundaries showing how time delay determines characteristic response patterns of these networks. Applying our theoretical analyses to concrete data we show that adaptation to osmotic stress in yeast is optimal in the sense of minimizing adaptation time without causing oscillatory behaviour, i.e., a critically damped response. In addition, our framework demonstrates that a slight increase of time delay in the NF-κB system might induce a switch from damped to sustained oscillatory behaviour. Thus, we demonstrate how delay differential equations can be used to explicitly study the delay in biochemical negative feedback systems. Our analysis also provides insight into how time delay may tune biological signal-response patterns and control the systems behaviour.

  10. Stochastic modeling of biochemical systems with multistep reactions using state-dependent time delay.

    Wu, Qianqian; Tian, Tianhai


    To deal with the growing scale of molecular systems, sophisticated modelling techniques have been designed in recent years to reduce the complexity of mathematical models. Among them, a widely used approach is delayed reaction for simplifying multistep reactions. However, recent research results suggest that a delayed reaction with constant time delay is unable to describe multistep reactions accurately. To address this issue, we propose a novel approach using state-dependent time delay to approximate multistep reactions. We first use stochastic simulations to calculate time delay arising from multistep reactions exactly. Then we design algorithms to calculate time delay based on system dynamics precisely. To demonstrate the power of proposed method, two processes of mRNA degradation are used to investigate the function of time delay in determining system dynamics. In addition, a multistep pathway of metabolic synthesis is used to explore the potential of the proposed method to simplify multistep reactions with nonlinear reaction rates. Simulation results suggest that the state-dependent time delay is a promising and accurate approach to reduce model complexity and decrease the number of unknown parameters in the models.

  11. The Effects of Pitch Shifts on Delay-Induced Changes in Vocal Sequencing in a Songbird

    Kelly, Conor W.


    Abstract Like human speech, vocal behavior in songbirds depends critically on auditory feedback. In both humans and songbirds, vocal skills are acquired by a process of imitation whereby current vocal production is compared to an acoustic target. Similarly, performance in adulthood relies strongly on auditory feedback, and online manipulations of auditory signals can dramatically alter acoustic production even after vocalizations have been well learned. Artificially delaying auditory feedback can disrupt both speech and birdsong, and internal delays in auditory feedback have been hypothesized as a cause of vocal dysfluency in persons who stutter. Furthermore, in both song and speech, online shifts of the pitch (fundamental frequency) of auditory feedback lead to compensatory changes in vocal pitch for small perturbations, but larger pitch shifts produce smaller changes in vocal output. Intriguingly, large pitch shifts can partially restore normal speech in some dysfluent speakers, suggesting that the effects of auditory feedback delays might be ameliorated by online pitch manipulations. Although birdsong provides a promising model system for understanding speech production, the interactions between sensory feedback delays and pitch shifts have not yet been assessed in songbirds. To investigate this, we asked whether the addition of a pitch shift modulates delay-induced changes in Bengalese finch song, hypothesizing that pitch shifts would reduce the effects of feedback delays. Compared with the effects of delays alone, combined delays and pitch shifts resulted in a significant reduction in behavioral changes in one type of sequencing (branch points) but not another (distribution of repeated syllables). PMID:28144622

  12. Factors Contribute to Delay Project Construction in Higher Learning Education Case Study UKM

    N.M. Tawil


    Full Text Available The delay in construction project completion is a common phenomenon that occurs in the construction industry, especially where the government projects are concerned. This survey will center on the Ninth Malaysia Plan project delay as evidenced in the Universiti Kebangsaan Malaysia campus. It will generally examine delay-related issues, which include the definition, type and category of delay, as well as the contributing factors (theoretically or practically that lead to delay in the project implementation. Data was compiled from literature review, interview and survey. Data obtained from the survey was analysed using the ‘relative Important Index (RII’ whereby the source with the highest RII is one that mostly influences the delay. The critical source of delay is due to the fact that the project contractor does not have enough working capital, the late advance payment, the delay in the client or consultant endorsing the study, issues involving contractor management, the scarcity of construction materials and new instructions for additional construction work.

  13. Effects of intrinsic stochasticity on delayed reaction-diffusion patterning systems

    Woolley, Thomas E.


    Cellular gene expression is a complex process involving many steps, including the transcription of DNA and translation of mRNA; hence the synthesis of proteins requires a considerable amount of time, from ten minutes to several hours. Since diffusion-driven instability has been observed to be sensitive to perturbations in kinetic delays, the application of Turing patterning mechanisms to the problem of producing spatially heterogeneous differential gene expression has been questioned. In deterministic systems a small delay in the reactions can cause a large increase in the time it takes a system to pattern. Recently, it has been observed that in undelayed systems intrinsic stochasticity can cause pattern initiation to occur earlier than in the analogous deterministic simulations. Here we are interested in adding both stochasticity and delays to Turing systems in order to assess whether stochasticity can reduce the patterning time scale in delayed Turing systems. As analytical insights to this problem are difficult to attain and often limited in their use, we focus on stochastically simulating delayed systems. We consider four different Turing systems and two different forms of delay. Our results are mixed and lead to the conclusion that, although the sensitivity to delays in the Turing mechanism is not completely removed by the addition of intrinsic noise, the effects of the delays are clearly ameliorated in certain specific cases. © 2012 American Physical Society.

  14. Delay-Limited Capacity in the Low Power Regime

    Rezki, Zouheir


    Outage performance of the M-block fading with additive white Gaussian noise (BF-AWGN) is investigated in the low-power regime. We consider delay-constrained constant-rate communications with perfect channel state information (CSI) at both the transmitter and the receiver (CSI-TR), under a shortterm power constraint (STPC) and a long-term power constraint (LTPC). Subject to STPC, we show that selection diversity that allocates all the power to the strongest block is asymptotically optimal. Then, we provide a simple characterization of the outage probability in the regime of interest. We quantify the reward due to CSI-TR over the constant-rate constant-power scheme and show that this reward increases with the delay constraint. For instance, for Rayleigh fading, we find that a power gain up to 4.3 dB is achievable. Subject to LTPC, we show that the above guidelines still holds and that the outage performance improves due to the flexibility of the LTPC over the STPC. More interestingly, we prove that LTPC allows zero-outage communication even at low SNR and characterize the delaylimited capacity at low SNR in a simple form. More precisely, we establish that the delay-limited capacity scales linearly with the power constraint, for a given M < 1. Our framework highlights the benefit of fading at low SNR as the delay-limited capacity may outperform the AWGN capacity. For instance, for Rayleigh fading and with M = 3, the delay-limited capacity is 16% higher than the capacity of an AWGN channel.

  15. Delayed effects of cortisol enhance fear memory of trace conditioning.

    Cornelisse, Sandra; van Ast, Vanessa A; Joëls, Marian; Kindt, Merel


    Corticosteroids induce rapid non-genomic effects followed by slower genomic effects that are thought to modulate cognitive function in opposite and complementary ways. It is presently unknown how these time-dependent effects of cortisol affect fear memory of delay and trace conditioning. This distinction is of special interest because the neural substrates underlying these types of conditioning may be differently affected by time-dependent cortisol effects. Delay conditioning is predominantly amygdala-dependent, while trace conditioning additionally requires the hippocampus. Here, we manipulated the timing of cortisol action during acquisition of delay and trace fear conditioning, by randomly assigning 63 men to one of three possible groups: (1) receiving 10mg hydrocortisone 240 min (slow cort) or (2) 60 min (rapid cort) before delay and trace acquisition, or (3) placebo at both times, in a double-blind design. The next day, we tested memory for trace and delay conditioning. Fear potentiated startle responses, skin conductance responses and unconditioned stimulus expectancy scores were measured throughout the experiment. The fear potentiated startle data show that cortisol intake 240 min before actual fear acquisition (slow cort) uniquely strengthened subsequent trace conditioned memory. No effects of cortisol delivery 60 min prior to fear acquisition were found on any measure of fear memory. Our findings emphasize that slow, presumably genomic, but not more rapid effects of corticosteroids enhance hippocampal-dependent fear memories. On a broader level, our findings underline that basic experimental research and clinically relevant pharmacological treatments employing corticosteroids should acknowledge the timing of corticosteroid administration relative to the learning phase, or therapeutic intervention.

  16. Dermographism and delayed pressure urticaria.

    Jauhar, Sachin; Staines, Konrad; McQueen, Marise; Watson, Ian B; Wray, David; Felix, David H


    There are few papers in the literature that describe pressure urticaria in the maxillofacial region. We present 2 cases and discuss the significance and principles of management. One case describes the diagnosis of pressure urticaria and the second describes the dental management of a patient with severe pressure urticaria.

  17. Stability criteria for T-S fuzzy systems with interval time-varying delays and nonlinear perturbations based on geometric progression delay partitioning method.

    Chen, Hao; Zhong, Shouming; Li, Min; Liu, Xingwen; Adu-Gyamfi, Fehrs


    In this paper, a novel delay partitioning method is proposed by introducing the theory of geometric progression for the stability analysis of T-S fuzzy systems with interval time-varying delays and nonlinear perturbations. Based on the common ratio α, the delay interval is unequally separated into multiple subintervals. A newly modified Lyapunov-Krasovskii functional (LKF) is established which includes triple-integral terms and augmented factors with respect to the length of every related proportional subintervals. In addition, a recently developed free-matrix-based integral inequality is employed to avoid the overabundance of the enlargement when dealing with the derivative of the LKF. This innovative development can dramatically enhance the efficiency of obtaining the maximum upper bound of the time delay. Finally, much less conservative stability criteria are presented. Numerical examples are conducted to demonstrate the significant improvements of this proposed approach.

  18. Delay-dependent observer-based stabilizing controller design for linear multiple state-delayed systems

    Dejin WANG


    This article concerns a coupled LMIs approach to delay-dependent observer-based output feedback stabilizing controller design for linear continuous-time systems with multiple state delays. The advantage of our proposed delay-dependent coupled LMIs criterion lies in that: (1) it can optimize one of multiple time delays with others selected properly, and at the same time, the feedback-gain and observer-gain can be obtained, respectively. (2) it is less conservative than the existing delay-independent ones in the literature. Algorithm to solve the coupled LMIs is also given. Numerical examples illustrate the effectiveness of our method.

  19. Isochronal synchronization of time delay and delay-coupled chaotic systems

    Grzybowski, J M V; Yoneyama, T [Instituto Tecnologico de Aeronautica, ITA, Praca Marechal Eduardo Gomes, 50, Vila das Acacias, Sao Jose dos Campos, SP, Brazil, CEP 12.228-900 (Brazil); Macau, E E N, E-mail:, E-mail:, E-mail: [Instituto Nacional de Pesquisas Espaciais, INPE, PO Box 515, Sao Jose dos Campos, SP, Brazil, CEP 12.227-010 (Brazil)


    This paper studies the problem of isochronal synchronization of time-delay chaotic systems featuring also coupling delay. Based on the Lyapunov-Krasovskii stability theory, sufficient conditions are derived for the stability of isochronal synchronization between a pair of identical chaotic systems. Such criteria permit the proper design of stable proportional linear feedback controller, more specifically, the design of adequate proportional feedback gain matrices. The proposed criteria are suited to systems with (i) intrinsic delay, (ii) coupling delay or (iii) both. Numerical simulations of the synchronization of delay-coupled systems are presented as examples of the application of the criteria.

  20. The Role of Drugs, Diet, and Food Additives in Hyperactivity.

    Harshbarger, Mary E.

    A variety of causes have been suggested for hyperactivity: anoxia and other adverse birth conditions, genetic factors, delayed maturation, maternal smoking and drinking during pregnancy, interaction of temperament and environment, lead poisoning, radiation stress, allergy and food additives, and deprivation of required stimulation. Treatments…

  1. Survey of time preference, delay discounting models

    John R. Doyle


    Full Text Available The paper surveys over twenty models of delay discounting (also known as temporal discounting, time preference, time discounting, that psychologists and economists have put forward to explain the way people actually trade off time and money. Using little more than the basic algebra of powers and logarithms, I show how the models are derived, what assumptions they are based upon, and how different models relate to each other. Rather than concentrate only on discount functions themselves, I show how discount functions may be manipulated to isolate rate parameters for each model. This approach, consistently applied, helps focus attention on the three main components in any discounting model: subjectively perceived money; subjectively perceived time; and how these elements are combined. We group models by the number of parameters that have to be estimated, which means our exposition follows a trajectory of increasing complexity to the models. However, as the story unfolds it becomes clear that most models fall into a smaller number of families. We also show how new models may be constructed by combining elements of different models. The surveyed models are: Exponential; Hyperbolic; Arithmetic; Hyperboloid (Green and Myerson, Rachlin; Loewenstein and Prelec Generalized Hyperboloid; quasi-Hyperbolic (also known as beta-delta discounting; Benhabib et al's fixed cost; Benhabib et al's Exponential / Hyperbolic / quasi-Hyperbolic; Read's discounting fractions; Roelofsma's exponential time; Scholten and Read's discounting-by-intervals (DBI; Ebert and Prelec's constant sensitivity (CS; Bleichrodt et al.'s constant absolute decreasing impatience (CADI; Bleichrodt et al.'s constant relative decreasing impatience (CRDI; Green, Myerson, and Macaux's hyperboloid over intervals models; Killeen's additive utility; size-sensitive additive utility; Yi, Landes, and Bickel's memory trace models; McClure et al.'s two exponentials; and Scholten and Read's trade

  2. A novel approach to delay-fractional-dependent stability criterion for linear systems with interval delay.

    An, Jiyao; Li, Zhiyong; Wang, Xiaomei


    This paper considers the problem of delay-fractional-dependent stability analysis of linear systems with interval time-varying state delay. By developing a delay variable decomposition approach, both the information of the variable dividing subinterval delay, and the information of the lower and upper bound of delay can be taken into full consideration. Then a new delay-fractional-dependent stability criterion is derived without involving any direct approximation in the time-derivative of the Lyapunov-Krasovskii (LK) functional via some suitable Jensen integral inequalities and convex combination technique. The merits of the proposed result lie in less conservatism, which are realized by choosing different Lyapunov matrices in the variable delay subintervals and estimating the upper bound of some cross term in LK functional more exactly. At last, two well-known numerical examples are employed to show the effectiveness and less conservatism of the proposed method.

  3. Millisecond laser machining of transparent materials assisted by a nanosecond laser with different delays.

    Pan, Yunxiang; Lv, Xueming; Zhang, Hongchao; Chen, Jun; Han, Bing; Shen, Zhonghua; Lu, Jian; Ni, Xiaowu


    A millisecond laser combined with a nanosecond laser was applied to machining transparent materials. The influences of delay between the two laser pulses on processing efficiencies and modified sizes were studied. In addition, a laser-supported combustion wave (LSCW) was captured during laser irradiation. An optimal delay corresponding to the highest processing efficiency was found for cone-shaped cavities. The modified size as well as the lifetime and intensity of the LSCW increased with the delay decreasing. Thermal cooperation effects of defects, overlapping effects of small modified sites, and thermal radiation from LSCW result in all the phenomena.

  4. A novel scheme based on minimum delay at the edges for optical burst switching networks

    Jinhui Yu(于金辉); Yijun Yang(杨毅军); Yuehua Chen(陈月华); Ge Fan(范戈)


    This paper proposes a novel scheme based on minimum delay at the edges (MDE) for optical burst switching(OBS) networks. This scheme is designed to overcome the long delay at the edge nodes of OBS networks.The MDE scheme features simultaneous burst assembly, channel scheduling, and pre-transmission of controlpacket. It also features estimated setup and explicit release (ESXR) signaling protocol. The MDE schemecan minimize the delay at the edge nodes for data packets, and improve the end-to-end latency performancefor OBS networks. In addition, comparing with the conventional scheme, the performances of the MDEscheme are analyzed in this paper.

  5. Directed Current Induced by an Symmetrically ac Force Coexisting with a Time-Delayed Feedback

    易述婷; 宋晖; 欧志娥; 艾保全; 熊建文


    We study the transport of overdamped Brownian particles in a symmetricaJly periodic potential in the presence of an asymmetrically ac driving force and a time-delayed feedback. It is found that for low frequencies, the average velocity can be negative by changing the driving amplitude, for high frequencies, there exists an optimized driving amplitude at which the average velocity takes its maximum value. Additionally, there is a threshold value of driving amplitude below which no directed transport can be obtained for high frequencies. For the large value of the delay time, the average velocity is independent of the delay time.

  6. Multipath time delay estimation of underwater acoustic sinusoidal signals

    TONG Feng; XU Xiaomei; FANG Shiliang


    To overcome the performance limitation of multipath time-delay estimation posed by underwater acoustic sinusoidal signals, an approach incorporating the frequency-domain weighting of the highly oscillatory Nonlinear Least Squares (NLS) cost function with the evolutionary optimization was proposed to facilitate the accurate estimation of the multipath timedelay of sinusoidal signals. In the described method, the number of the effective multipath signals, which is included into the parameter model as well as the multipath time-delay and amplitude factor, can be estimated simultaneously thus avoiding the requirement of additional computation. The experimental results performed with numerical simulation and sea-trial data are provided, demonstrating the effectiveness and precision enhancement of the proposed algorithm.

  7. Multi-object fixed delay Michelson interferometer for astronomical observation

    Zhang, Kai; Zhu, Yongtian; Wang, Lei; Chen, Yi; Wang, Liang


    Optical interferometry isn't only widely applied into optical workshop, but also makes great contribution in astronomical observation. A multi-object fixed delay Michelson interferometer commissioned to search extra-solar planet (exoplanet) is introduced here. Fixed delay of 1.9mm, which is good for stellar radial velocity measuring precision, is obtained by two interference arms with different materials. This configuration has different refractive indexes and physical characteristics so that supplies wider field of view and better thermal stability. In addition, compact interference component with three glued prisms and smart structure are the other important features. Because of vibration influence, the combination among the prisms is a direct and effective method. And the reason why make the structure as small as possible is of central obscuration under the workspace of interferometer.

  8. Remote optimal state estimation over communication channels with random delays

    Mahmoud, Magdi S.


    This paper considers the optimal estimation of linear systems over unreliable communication channels with random delays. In this work, it is assumed that the system to be estimated is far away from the filter. The observations of the system are capsulized without time stamp and then transmitted to the network node at which the filter is located. The probabilities of time delays are assumed to be known. The event-driven estimation scheme is applied in this paper and the estimate of the states is updated only at each time instant when any measurement arrives. To capture the feature of communication, the system considered is augmented, and the arrived measurements are regarded as the uncertain observations of the augmented system. The corresponding optimal estimation algorithm is proposed and additionally, a numerical simulation represents the performance of this work. © 2014 The authors. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.

  9. Construction of New Delay-Tolerant Space-Time Codes

    Sarkiss, Mireille; Damen, Mohamed Oussama; Belfiore, Jean-Claude


    Perfect Space-Time Codes (STC) are optimal codes in their original construction for Multiple Input Multiple Output (MIMO) systems. Based on Cyclic Division Algebras (CDA), they are full-rate, full-diversity codes, have Non-Vanishing Determinants (NVD) and hence achieve Diversity-Multiplexing Tradeoff (DMT). In addition, these codes have led to optimal distributed space-time codes when applied in cooperative networks under the assumption of perfect synchronization between relays. However, they loose their diversity when delays are introduced and thus are not delay-tolerant. In this paper, using the cyclic division algebras of perfect codes, we construct new codes that maintain the same properties as perfect codes in the synchronous case. Moreover, these codes preserve their full-diversity in asynchronous transmission.

  10. Noise-enhanced phase synchronization in time-delayed systems.

    Senthilkumar, D V; Shrii, M Manju; Kurths, J


    We investigate the phenomenon of noise-enhanced phase synchronization (PS) in coupled time-delay systems, which usually exhibit non-phase-coherent attractors with complex topological properties. As a delay system is essentially an infinite dimensional in nature with multiple characteristic time scales, it is interesting and crucial to understand the interplay of noise and the time scales in achieving PS. In unidirectionally coupled systems, the response system adjust all its time scales to that of the drive, whereas both subsystems adjust their rhythms to a single (main time scale of the uncoupled system) time scale in bidirectionally coupled systems. We find similar effects for both a common and an independent additive Gaussian noise.

  11. Parameter identification of linear discrete stochastic systems with time delays

    Wong, E. C.


    An identification algorithm that uses the maximum likelihood technique to identify the unknown time delays, plant parameters, and noise covariances of linear discrete stochastic systems is presented. Cases of additive white noise and colored measurement noises are considered. The likelihood function is evaluated using either a minimum-variance (Kalman) filter or a minimal-order observer. The Kalman filter is used in the identification algorithm to provide minimum-variance estimates. The minimal-order observer is a lower-dimensional and computationally simpler filter, and is advantageous especially for systems with long delays. It provides a less optimal solution to the minimum-mean-square state estimation problem. The colored-noise observer algorithm has the disadvantage of having to compute an extra error covariance matrix of lower order.

  12. Age differences in learning, immediate and one week delayed recall.

    Schneider, N G; Gritz, E R; Jarvik, M E


    In an initial study, differences in learning and immediate recall were observed for groups of young and aged subjects on several measures. Retest date showed some differential loss for aged subjects after 1 week. Conclusions regarding long-term retention per se were not possible due to the nature of the design. In a second study, additional aged and young groups of subjects were run under delayed recall conditions. The data from these two groups were combined with data from the first study, with care taken to match subjects on a number of variables (health, education, intelligence). The results showed age-related differences for measures of learning and immediate recall but not for delayed 1 week retention.

  13. Delays in Building Construction Projects in Ghana

    Adwoa B Agyakwah-Baah


    Full Text Available This study investigates the causes of delay of building construction projects in Ghana to determine the most important according to the key project participants; clients, consultants, and contractors. Thirty-two possible causes of delay were identified from the literature and semi-structured interviews of 15 key players in the implementation process. These delay factors were further categorised into nine major groups. The list of delay causes was subjected to a questionnaire survey for the identification of the most important causes of delay. The field survey included 130 respondents made up of 39 contractors, 37 clients and 54 consultants. The relative importance of the individual causes and the groups were calculated and ranked by their relative importance index. The overall results of the study indicate that the respondents generally agree that financial group factors ranked highest among the major factors causing delay in construction projects in Ghana. The financial group factors were delay in honouring payment certificates, difficulty in accessing credit and fluctuation in prices. Materials group factors are second followed by scheduling and controlling factors.

  14. Delayed diagnosis of narcolepsy: characterization and impact.

    Thorpy, Michael J; Krieger, Ana C


    Narcolepsy, a chronic neurologic condition resulting from dysregulation of the sleep-wake cycle, usually has an onset at an early age. However, a long delay until diagnosis has been consistently reported in the literature across countries and several publications have focused on characterizing this delay. Most studies report a mean delay to diagnosis of up to 15 years, with individual cases of >60 years, although a trend over time toward a shorter diagnostic delay has been suggested. While variables associated with this delay have been identified, a lack of symptom recognition resulting in misdiagnosis prior to reaching the narcolepsy diagnosis is the likely underlying reason. This lack of symptom recognition is especially relevant considering the high comorbidity burden that has been shown in patients with narcolepsy as some disorders manifest with symptoms that overlap with narcolepsy. A consequence of delayed diagnosis is delayed treatment, which affects the burden of disease. Substantial detrimental effects on health-care resource utilization, employment, and quality of life have been described after narcolepsy onset and prior to the diagnosis of narcolepsy. This review highlights the importance of closing the diagnostic gap by expanding awareness of narcolepsy and its symptoms.

  15. Global exponential stability of mixed discrete and distributively delayed cellular neural network

    Yao Hong-Xing; Zhou Jia-Yan


    This paper concernes analysis for the global exponential stability of a class of recurrent neural networks with mixed discrete and distributed delays. It first proves the existence and uniqueness of the balance point, then by employing the Lyapunov-Krasovskii functional and Young inequality, it gives the sufficient condition of global exponential stability of cellular neural network with mixed discrete and distributed delays, in addition, the example is provided to illustrate the applicability of the result.



    In this paper, we study the existence and stability of an equilibrium of discrete-time Cohen-Grossberg BAM Neural Networks with delays. We obtain several sufficient conditions ensuring the existence and stability of an equilibrium of such systems, using discrete Halanay-type inequality and vector Lyapunov methods. In addition, we show that the proposed sufficient condition is independent of the delay parameter. An example is given to demonstrate the effectiveness of the results obtained.

  17. Analysis of boundary point (break point) in Linear Delay Model for nanoscale VLSI standard cell library characterization at PVT corners

    Agarwal, Gaurav Kumar


    In VLSI chip design flow, Static Timing Analysis (STA) is used for fast and accurate analysis of data-path delay. This process is fast because delay is picked from Look Up Tables (LUT) rather than conventional SPICE simulations. But accuracy of this method depends upon the underlying delay model with which LUT was characterized. Non Linear Delay Model (NLDM) based LUTs are quite common in industries. These LUT requires huge amount to time during characterization because of huge number of SPICE simulations done at arbitrary points. To improve this people proposed various other delay models like alpha-power and piecewise linear delay models. Bulusu et al proposed Linear Delay Model(LDM) which reduces LUT generation time to 50 percent. LDM divides delay curve w.r.t input rise time(trin) into two different region one is linear and other is non-linear. This boundary point between linear and non- linear region was called break point (trb). Linear region will be done if we simulate at only two points. This advantage...

  18. Delay-dependent robust H∞ controller design for a class of nonlinear uncertainty time-delay systems with input delay


    Based on an appropriate Lyapunov function,this paper analyzes the design of a delay-dependent robust H∞ state feedback control,with a focus on a class of non linear uncertainty linear time-delay systems with input delay using linear matrix inequalities.Under the condition that the nonlinear uncertain functions are gain bounded,a sufficient condition dependent on the delays of the state and input is presented for the existence of H∞ controller.The proposed controller not only stabilized closed-loop uncertain systems but also guaranteed a prescribed H∞ norm bound of closed-loop transfer matrix from the disturbance to controlled output.By solving a linear matrix inequation,we can obtain the robust H∞ controller.An example is given to show the effectiveness of the proposed method.


    李丽香; 彭海朋; 卢辉斌; 关新平


    In this paper two different types of feedback control technique are discussed: the standard feedback control and the time-delay feedback control which have been successfully used in many control systems. In order to understand to what extent the two different types of control technique are useful in delayed chaotic systems, some analytic stabilization conditions for chaos control from the two types of control technique are derived based on Lyapunov stabilization arguments. Similarly, we discuss the tracking problem by applying the time-delay feedback control. Finally, numerical examples are provided.

  20. Technical Progress of China's Delayed Coking Technology

    Zhang Lixin; Li Hejie


    This article introduces the recent advances of China in the fields of process technology of delayed coking, enlarged equipment size, hydraulic decoking, automatic control and environmental protection. By the end of 2004 the total capacity of delayed coking units in China had reached 37.24Mt/a with the maximum coke drum diameter equating to 9.4 m. This article also presents the investment in delayed cokers and the current production status while pointing out the existing problems and future development trends.

  1. Synchronisation of time-delay systems

    Bünner, M J; Bünner, Martin J.; Just, Wolfram


    We present the linear-stability analysis of synchronised states in coupled time-delay systems. There exists a synchronisation threshold, for which we derive upper bounds, which does not depend on the delay time. We prove that at least for scalar time-delay systems synchronisation is achieved by transmitting a single scalar signal, even if the synchronised solution is given by a high-dimensional chaotic state with a large number of positive Lyapunov-exponents. The analytical results are compared with numerical simulations of two coupled Mackey-Glass equations.

  2. Delayed self-synchronization in homoclinic chaos

    Arecchi, F. T.; Meucci, R.; Allaria, E.; di Garbo, A.; Tsimring, L. S.


    The chaotic spike train of a homoclinic dynamical system is self-synchronized by applying a time-delayed correction proportional to the laser output intensity. Due to the sensitive nature of the homoclinic chaos to external perturbations, stabilization of very long-periodic orbits is possible. On these orbits, the dynamics appears chaotic over a finite time, but then it repeats with a recurrence time that is slightly longer than the delay time. The effect, called delayed self-synchronization, displays analogies with neurodynamic events that occur in the buildup of long-term memories.

  3. Transcriptional delay stabilizes bistable gene networks

    Gupta, Chinmaya; López, José Manuel; Ott, William; Josić, Krešimir; Bennett, Matthew R.


    Transcriptional delay can significantly impact the dynamics of gene networks. Here we examine how such delay affects bistable systems. We investigate several stochastic models of bistable gene networks and find that increasing delay dramatically increases the mean residence times near stable states. To explain this, we introduce a non-Markovian, analytically tractable reduced model. The model shows that stabilization is the consequence of an increased number of failed transitions between stable states. Each of the bistable systems that we simulate behaves in this manner. PMID:23952450

  4. Statistical Elmore delay of RC interconnect tree

    Dong Gang; Yang Yang; Chai Chang-Chun; Yang Yin-Tang


    As feature size keeps scaling down, process variations can dramatically reduce the accuracy in the estimation of interconnect performance. This paper proposes a statistical Elmore delay model for RC interconnect tree in the presence of process variations. The suggested method translates the process variations into parasitic parameter extraction and statistical Elmore delay evaluation. Analytical expressions of mean and standard deviation of interconnect delay can be obtained in a given fluctuation range of interconnect geometric parameters. Experimental results demonstrate that the approach matches well with Monte Carlo simulations. The errors of proposed mean and standard deviation are less than 1% and 7%, respectively. Simulations prove that our model is efficient and accurate.

  5. GBR技术用于上颌前牙唇侧骨缺损的延期种植修复的效果观察%Clinical Effect of Guided Bone Regeneration in Delayed Implant Restoration of Bone Defects in the Maxillary Anterior Region



    Objective To probe into the effect of double guided bone regeneration applied in delayed implant restoration of bone defects in the maxillary anterior region. Methods The selected study subjects, twelve outpatients from January 2012 to August 2013 in Stomatological Hospital of Yangzhou restored partial bone defects after the primary GBR treatment on the conditon of the alveolar bone resorption and serious bone implant thinning due to cyst of jaw, trauma, dental caries or periodontal disease after the removal of the anterior teeth. The implants were inserted and GBR technique was applied once again 4-6 months later after the healing. Stage II surgeries of dental implantion were done 4-6 months later and dental crown restoration was completed. All the cases in the repair were taken local dental and oral panoramic X-rays at post-operation simultaneously, 3 months later, 6 months later and 12 months later respectively. Follow-up comparisons in peri implant bone level, bone density and osseointergration degree were conducted. Results Two cases of patients with GBR technology and 12 cases of implant were used in the process of planting, and the results showed that the X film was closely related to the alveolar bone. Conclusion The results showed that in all cases with 6 months to 12 months loading the peri implant bone level was stable locating above the first thread and ideal osseointergration was achieved.%目的:观察两次运用引导骨再生技术(GBR)在上颌前牙唇侧区骨质严重缺损种植修复中的应用效果。方法选取2012年1月~2013年8月我院收治的因外伤或颌骨囊肿拔牙后导致牙槽骨严重缺损患者12例作为研究对象,在首次进行GBR恢复部分骨缺损,愈合4~6个月后,再进行种植体植入术,同时再次使用GBR技术。术后4~6月进行种植二期、牙冠修复完成,所有患者均在修复完成当天、3个月、6个月、12个月行局部牙片和口腔全景片,对比种植

  6. Perspectives on Additive Manufacturing

    Bourell, David L.


    Additive manufacturing (AM) has skyrocketed in visibility commercially and in the public sector. This article describes the development of this field from early layered manufacturing approaches of photosculpture, topography, and material deposition. Certain precursors to modern AM processes are also briefly described. The growth of the field over the last 30 years is presented. Included is the standard delineation of AM technologies into seven broad categories. The economics of AM part generation is considered, and the impacts of the economics on application sectors are described. On the basis of current trends, the future outlook will include a convergence of AM fabricators, mass-produced AM fabricators, enabling of topology optimization designs, and specialization in the AM legal arena. Long-term developments with huge impact are organ printing and volume-based printing.

  7. Sarks as additional fermions

    Agrawal, Jyoti; Frampton, Paul H.; Jack Ng, Y.; Nishino, Hitoshi; Yasuda, Osamu


    An extension of the standard model is proposed. The gauge group is SU(2) X ⊗ SU(3) C ⊗ SU(2) S ⊗ U(1) Q, where all gauge symmetries are unbroken. The colour and electric charge are combined with SU(2) S which becomes strongly coupled at approximately 500 GeV and binds preons to form fermionic and vector bound states. The usual quarks and leptons are singlets under SU(2) X but additional fermions, called sarks. transform under it and the electroweak group. The present model explains why no more than three light quark-lepton families can exist. Neutral sark baryons, called narks, are candidates for the cosmological dark matter having the characteristics designed for WIMPS. Further phenomenological implications of sarks are analyzed i including electron-positron annihilation. Z 0 decay, flavor-changing neutral currents. baryon-number non-conservation, sarkonium and the neutron electric dipole moment.

  8. Influence of strong noise on the decline and propagation of population in the delayed Malthus-Verhulst model

    Cai, Jian-Chun; Mei, Dong-Cheng


    The effects of strong noise on the decline and propagation processes of a population in the Malthus-Verhulst model with time delay are investigated by a stochastic simulation. Time delays in two different processes are concurrent in ecosystems. The simulation results indicate that: The stability of the population is enhanced by the decreasing multiplicative noise intensity and the increasing delay time. The replacement of old individuals with young ones is accelerated by an increasing multiplicative noise intensity, an increasing additive noise intensity and a decreasing delay time. An increasing multiplicative noise intensity will drive the population of species to fluctuate more largely.

  9. Intentional signals during saccadic and reaching delays in the human posterior parietal cortex.

    Galati, Gaspare; Committeri, Giorgia; Pitzalis, Sabrina; Pelle, Gina; Patria, Fabiana; Fattori, Patrizia; Galletti, Claudio


    In the monkey posterior parietal cortex (PPC), there is clear evidence of anatomically segregated neuronal populations specialized for planning saccades and arm-reaching movements. However, functional neuroimaging studies in humans have yielded controversial results. Here we show that the human PPC contains distinct subregions responsive to salient visual cues, some of which combine spatial and action-related signals into 'intentional' signals. Participants underwent event-related functional magnetic resonance imaging while performing delayed saccades and long-range arm reaches instructed by visual cues. We focused on activity in the time period following the cue and preceding the actual movement. The use of individual cortical surface reconstructions with detailed sulcal labeling allowed the definition of six responsive regions with distinctive anatomical locations in the PPC. Each region exhibited a distinctive combination of transient and sustained signals during the delay, modulated by either the cue spatial location (contralateral vs. ipsilateral), the instructed action (saccades vs. reaching) or both. Importantly, a lateral and a medial dorsal parietal region showed sustained responses during the delay preferentially for contralateral saccadic and reaching trials, respectively. In the lateral region, preference for saccades was evident only as a more sustained response during saccadic vs. reaching delays, whereas the medial region also showed a higher transient response to cues signaling reaching vs. saccadic actions. These response profiles closely match the behavior of neurons in the macaque lateral and medial intraparietal area, respectively, and suggest that these corresponding human regions are encoding spatially directed action plans or 'intentions'.

  10. Stability and oscillations in a slow-fast flexible joint system with transformation delay

    Jiang, Shan-Ying; Xu, Jian; Yan, Yao


    Flexible joints are usually used to transfer velocities in robot systems and may lead to delays in motion transformation due to joint flexibility. In this paper, a link-rotor structure connected by a flexible joint or shaft is firstly modeled to be a slow-fast delayed system when moment of inertia of the lightweight link is far less than that of the heavy rotor. To analyze the stability and oscillations of the slow-fast system, the geometric singular perturbation method is extended, with both slow and fast manifolds expressed analytically. The stability of the slow manifold is investigated and critical boundaries are obtained to divide the stable and the unstable regions. To study effects of the transformation delay on the stability and oscillations of the link, two quantitatively different driving forces derived from the negative feedback of the link are considered. The results show that one of these two typical driving forces may drive the link to exhibit a stable state and the other kind of driving force may induce a relaxation oscillation for a very small delay. However, the link loses stability and undergoes regular periodic and bursting oscillation when the transformation delay is large. Basically, a very small delay does not affect the stability of the slow manifold but a large delay affects substantially.

  11. Intercellular delay regulates the collective period of repressively coupled gene regulatory oscillator networks.

    Wang, Yongqiang; Hori, Yutaka; Hara, Shinji; Doyle, Francis J


    Most biological rhythms are generated by a population of cellular oscillators coupled through intercellular signaling. Recent experimental evidence shows that the collective period may differ significantly from the autonomous period in the presence of intercellular delays. The phenomenon has been investigated using delay-coupled phase oscillators, but the proposed phase model contains no direct biological mechanism, which may weaken the model's reliability in unraveling biophysical principles. Based on a published gene regulatory oscillator model, we analyze the collective period of delay-coupled biological oscillators using the multivariable harmonic balance technique. We prove that, in contradiction to the common intuition that the collective period increases linearly with the coupling delay, the collective period turns out to be a periodic function of the intercellular delay. More surprisingly, the collective period may even decrease with the intercellular delay when the delay resides in certain regions. The collective period is given in a closed-form in terms of biochemical reaction constants and thus provides biological insights as well as guidance in synthetic-biological-oscillator design. Simulation results are given based on a segmentation clock model to confirm the theoretical predictions.

  12. Does Bilingualism Delay the Development of Dementia?

    Amy L Atkinson


    Full Text Available It has been suggested that bilingualism (where individuals speak two languages may delay the development of dementia. However, much of the research is inconclusive. Some researchers have reported that bilingualism delays the onset and diagnosis of dementia, whilst other studies have found weak or even detrimental effects. This paper reviews a series of nine empirical studies, published up until March 2016, which investigated whether bilingualism significantly delays the onset of dementia. The article also explores whether the inconsistent findings can be attributed to differences in study designs or the definitions of bilingualism used between studies. Based on current evidence, it appears that lifelong bilingualism, where individuals frequently use both languages, may be protective against dementia. However, becoming bilingual in adulthood or using the second language infrequently is unlikely to substantially delay onset of the disease.

  13. Uranium Determination by Delayed Neutron Counting


    <正>Uranium is a very important resource in nuclear industry, especially in the exploiture of nuclear energy. Determination of uranium using delayed neutron counting (DNC) is simple, non-destructive, and

  14. Endotoxin contamination delays the foreign body reaction

    van Putten, Sander M.; Wubben, Maike; Plantinga, Josee A.; Hennink, Wim E.; van Luyn, Marja J. A.; Harmsen, Martin C.


    Biomaterials are at continuous risk of bacterial contamination during production and application. In vivo, bacterial contamination of biomaterials delays the foreign body reaction (FBR). Endotoxins such as lipopolysaccharides (LPS), major constituents of the bacterial cell wall, are potent stimulato

  15. Monolithic Time Delay Integrated APD Arrays Project

    National Aeronautics and Space Administration — The overall goal of the proposed program by Epitaxial Technologies is to develop monolithic time delay integrated avalanche photodiode (APD) arrays with sensitivity...

  16. Lauch of CERN particle accelerator delayed


    "Scientists seeking to uncover the secrets of the universe will have to wait a little longer after the CERN laboratory inSwitzerland yesterday confirmed a delay in tests of its massive new particle accelerator." (1 page)

  17. Continuous retrieval of delayed Raman polaritons

    Smartsev, Slava; Davidson, Nir; Firstenberg, Ofer


    We use a Raman four-wave mixing process to read out light from an atomic coherence which is continuously written. This realizes a continuous source of polaritons having been delayed or effectively stored for a finite duration. Contrary to slow-light delay, which depends on the atom number and population distribution, here the effective storage duration is determined solely by intensive properties of the system, approaching the ground-state natural lifetime at the weak driving limit. The generated polaritons are background free. We experimentally probe these properties utilizing spatial atomic diffusion as an 'internal clock' for the write-read delay. A continuous source of delayed polaritons can replace discrete write-read procedures when the atomic evolution is the subject of interest, for example, when dipolar interactions lead to retrieval of non-classical light.

  18. Lensing Time Delays and Cosmological Complementarity

    Linder, Eric V


    Time delays in strong gravitational lensing systems possess significant complementarity with distance measurements to determine the dark energy equation of state, as well as the matter density and Hubble constant. Time delays are most useful when observations permit detailed lens modeling and variability studies, requiring high resolution imaging, long time monitoring, and rapid cadence. We quantify the constraints possible between a sample of 150 such time delay lenses and a near term supernova program, such as might become available from an Antarctic telescope such as KDUST and the Dark Energy Survey. Adding time delay data to supernovae plus cosmic microwave background information can improve the dark energy figure of merit by almost a factor 5 and determine the matter density \\Omega_m to 0.004, Hubble constant h to 0.7%, and dark energy equation of state time variation w_a to 0.26, systematics permitting.

  19. Phase synchronization in time-delay systems.

    Senthilkumar, D V; Lakshmanan, M; Kurths, J


    Though the notion of phase synchronization has been well studied in chaotic dynamical systems without delay, it has not been realized yet in chaotic time-delay systems exhibiting non-phase-coherent hyperchaotic attractors. In this paper we report identification of phase synchronization in coupled time-delay systems exhibiting hyperchaotic attractor. We show that there is a transition from nonsynchronized behavior to phase and then to generalized synchronization as a function of coupling strength. These transitions are characterized by recurrence quantification analysis, by phase differences based on a transformation of the attractors, and also by the changes in the Lyapunov exponents. We have found these transitions in coupled piecewise linear and in Mackey-Glass time-delay systems.

  20. How Can Atherosclerosis Be Prevented or Delayed?

    ... page from the NHLBI on Twitter. How Can Atherosclerosis Be Prevented or Delayed? Taking action to control ... Rate This Content: NEXT >> Featured Video What is atherosclerosis? 05/22/2014 Describes how the build-up ...

  1. The SAS-3 delayed command system

    Hoffman, E. J.


    To meet the requirements arising from the increased complexity of the power, attitude control and telemetry systems, a full redundant high-performance control section with delayed command capability was designed for the Small Astronomy Satellite-3 (SAS-3). The relay command system of SAS-3 is characterized by 56 bystate relay commands, with capability for handling up to 64 commands in future versions. The 'short' data command service of SAS-1 and SAS-2 consisting of shifting 24-bit words to two users was expanded to five users and augmented with a 'long load' data command service (up to 4080 bits) used to program the telemetry system and the delayed command subsystem. The inclusion of a delayed command service ensures a program of up to 30 relay or short data commands to be loaded for execution at designated times. The design and system operation of the SAS-3 command section are analyzed, with special attention given to the delayed command subsystem.

  2. Internet end-to-end delay dynamics

    Zhu Changhua; Pei Changxing; Li Jiandong; Chen Nan; Yi Yunhui


    End-to-end delay is one of the most important characteristics of Internet end-to-end packet dynamics, which can be applied to quality of services (QoS) management, service level agreement (SLA) management, congestion control algorithm development, etc. Nonstationarity and nonlinearity are found by the analysis of various delay series measured from different links. The fact that different types of links have different degree of Self-Similarity is also obtained. By constructing appropriate network architecture and neural functions, functional networks can be used to model the Internet end-to-end nonlinear delay time series. Furthermore, by using adaptive parameter studying algorithm, the nonstationarity can also be well modeled. The numerical results show that the provided functional network architecture and adaptive algorithm can precisely characterize the Internet end-to-end delay dynamics.

  3. The Economic Promise of Delayed Aging.

    Goldman, Dana


    Biomedicine has made enormous progress in the last half century in treating common diseases. However, we are becoming victims of our own success. Causes of death strongly associated with biological aging, such as heart disease, cancer, Alzheimer's disease, and stroke-cluster within individuals as they grow older. These conditions increase frailty and limit the benefits of continued, disease-specific improvements. Here, we show that a "delayed-aging" scenario, modeled on the biological benefits observed in the most promising animal models, could solve this problem of competing risks. The economic value of delayed aging is estimated to be $7.1 trillion over 50 years. Total government costs, including Social Security, rise substantially with delayed aging--mainly caused by longevity increases--but we show that these can be offset by modest policy changes. Expanded biomedical research to delay aging appears to be a highly efficient way to forestall disease and extend healthy life.

  4. Analysis of Aggregation Delay for Multisource Sensor Data with On-Off Traffic Pattern in Wireless Body Area Networks

    Kim, Un-Ha; Kong, Eutteum; Choi, Hyun-Ho; Lee, Jung-Ryun


    Data aggregation plays an important role to improve the transmission efficiency in wireless body area networks (WBANs); however, it inherently induces additional aggregation delay. Therefore, the effect of packet aggregation on WBAN applications, which are vulnerable to delay, must be analyzed rigorously. In this paper, we analyze the packet aggregation delay for multisource sensor data with an on-off traffic pattern in WBANs. Considering two operational parameters of the aggregation threshold and aggregation timer, we calculate the probability that a packet aggregation occurs during a unit time and then derive the average aggregation delay in closed-form. The analysis results show that the aggregation delay increases as the aggregation timer or aggregation threshold increases, but is bounded below a certain level according to the number of active sensors and their on-off traffic attribute. This implies that the data aggregation technique can maximize the transmission efficiency while satisfying a given delay requirement in the WBAN system. PMID:27706029

  5. The effect and design of time delay in feedback control for a nonlinear isolation system

    Sun, Xiuting; Xu, Jian; Fu, Jiangsong


    The optimum value of time delay of active control used in a nonlinear isolation system for different types of external excitation is studied in this paper. Based on the mathematical model of the nonlinear isolator with time-delayed active control, the stability, response and displacement transmissibility of the system are analyzed to obtain the standards for appropriate values of time delay and control strengths. The effects of nonlinearity and time delay on the stability and vibration response are discussed in details. For impact excitation and random excitation, the optimal value of time delay is obtained based on the vibration dissipation time via eigenvalues analysis, while for harmonic excitation, the optimal values are determined based on multiple vibration properties including natural frequency, amplitude death region and effective isolation region by the Averaging Method. This paper establishes the relationship between the parameters and vibration properties of a nonlinear isolation system which provides the guidance for optimizing time-delayed active control for different types of excitation in engineering practices.

  6. Improvement of Delayed Neutron Counting System

    YUAN; Guo-jun; XIAO; Cai-jin; YANG; Wei; ZHANG; Gui-ying; JIN; Xiang-chun; WANG; Ping-sheng; NI; Bang-fa


    <正>A new delayed neutron counting system, which is good at qualitative and quantitative analysis of fissionable nuclide mixture, will be established at China Advanced Research Reactor (CARR). We use 3 He proportional counters to count the delayed neutrons after the samples irradiated by reactor neutrons, including U3O8-stantard, uranium ore and enriched uranium. Then, the counting efficiency and limit of this system were calculated.

  7. Improved control of delayed measured systems

    Claussen, Jens Christian; Schuster, Heinz Georg


    In this paper, we address the question of how the control of delayed measured chaotic systems can be improved. Both unmodified Ott-Grebogi-Yorke control and difference control can be successfully applied only for a certain range of Lyapunov numbers depending on the delay time. We show that this limitation can be overcome by at least two classes of methods, namely, by rhythmic control and by the memory methods of linear predictive logging control and memory difference control.

  8. Analysis of ion dynamics and peak shapes for delayed extraction time-of-flight mass spectrometers

    Collado, V. M.; Ponciano, C. R.; Fernandez-Lima, F. A.; da Silveira, E. F.


    The dependence of time-of-flight (TOF) peak shapes on time-dependent extraction electric fields is studied theoretically. Conditions for time focusing are analyzed both analytically and numerically for double-acceleration-region TOF spectrometers. Expressions for the spectrometer mass resolution and for the critical delay time are deduced. Effects due to a leakage field in the first acceleration region are shown to be relevant under certain conditions. TOF peak shape simulations for the delayed extraction method are performed for emitted ions presenting a Maxwellian initial energy distribution. Calculations are compared to experimental results of Cs+ emission due to CsI laser ablation.

  9. Operant variability when reinforcement is delayed.

    Wagner, Katie; Neuringer, Allen


    Operant responses are often weakened when delays are imposed between the responses and reinforcers. We examined what happens when delayed reinforcers were contingent upon operant response variability. Three groups of rats were rewardedfor varying their response sequences, with onegroup rewarded for high variability, another for middle, and the third for low levels. Consistent with many reports in the literature, responding slowed significantly in all groups as delays were lengthened. Consistent with other reports, large differences in variability were maintained across the three groups despite the delays. Reinforced variability appears to be relatively immune to disruption by such things as delays, response slowing, prefeeding, and noncontingent reinforcement. Furthermore, the small effects on variability depended on baseline levels: As delays lengthened, variability increased in the low group, was statistically unchanged in the middle group, and decreased in the high group, an interaction similar to that reported previously when reinforcement frequencies were lowered. Thus, variable operant responding is controlled by reinforcement contingencies, but sometimes differently than more commonly studied repetitive responding.

  10. Optimal Control with Time Delays via the Penalty Method

    Mohammed Benharrat


    Full Text Available We prove necessary optimality conditions of Euler-Lagrange type for a problem of the calculus of variations with time delays, where the delay in the unknown function is different from the delay in its derivative. Then, a more general optimal control problem with time delays is considered. Main result gives a convergence theorem, allowing us to obtain a solution to the delayed optimal control problem by considering a sequence of delayed problems of the calculus of variations.


    WANG Huailei; WANG Zaihua; HU Haiyan


    This paper studies the local dynamics of an SDOF system with quadratic and cubic stiffness terms, and with linear delayed velocity feedback. The analysis indicates that for a sufficiently large velocity feedback gain, the equilibrium of the system may undergo a number of stability switches with an increase of time delay, and then becomes unstable forever. At each critical value of time delay for which the system changes its stability, a generic Hopf bifurcation occurs and a periodic motion emerges in a one-sided neighbourhood of the critical time delay. The method of Fredholm alternative is applied to determine the bifurcating periodic motions and their stability. It stresses on the effect of the system parameters on the stable regions and the amplitudes of the bifurcating periodic solutions.

  12. Delay-dependent H-infinity control for continuous time-delay systems via state feedback

    Xinchun JIA; Yibo GAO; Jingmei ZHANG; Nanning ZHENG


    The delay-dependent H-infinity analysis and H-infinity control problems for continuous time-delay systems are studied. By introducing an equality with some free weighting matrices, an improved criterion of delay-dependent stability with H-infinity performance for such systems is presented, and a criterion of existence and some design methods of delay-dependent H-infinity controller for such systems are proposed in term of a set of matrix inequalities, which is solved efficiently by an iterative algorithm. Further, the corresponding results for the delay-dependent robust H-infinity analysis and robust H-infinity control problems for continuous time-delay uncertain systems are given. Finally, two numerical examples are given to illustrate the efficiency of the proposed method by comparing with the other existing results.

  13. Design of a Novel Current Balanced Voltage Controlled Delay Element

    Pooja Saxena


    Full Text Available This paper presents a design of fast voltage controlled delay element based on modified version of low noise Current Balanced Logic (CBL. This delay element provides identical rising and falling edge delays controlled by the single control voltage. The post layout tunable delay range is from 140 ps to 800 ps over control voltage range of 0 to 2.1 V. An analysis for the delay element is also presented, which is in agreement with the simulated delays. A Delay Lock Loop (DLL is designed using this delay element to verify its performance.

  14. Interconnected delay and state observer for nonlinear systems with time-varying input delay

    Léchappé, V; Moulay, Emmanuel; Plestan, F; Glumineau, A.


    International audience; This work presents a general framework to estimate both state and delay thanks to two interconnected observers. This scheme can be applied to a large class of nonlinear systems with time-varying input delay. In order to illustrate this approach, a new delay observer based on an optimization technique is proposed. Theoretical results are illustrated and compared with existing works in simulation.

  15. Delay dependent stability criteria for recurrent neural networks with time varying delays

    Zhanshan WANG; Huaguang ZHANG


    This paper aims to present some delay-dependent global asymptotic stability criteria for recurrent neural networks with time varying delays.The obtained results have no restriction on the magnitude of derivative of time varying delay,and can be easily checked due to the form of linear matrix inequality.By comparison with some previous results,the obtained results are less conservative.A numerical example is utilized to demonstrate the effectiveness of the obtained results.

  16. Delay-dependent guaranteed cost control for uncertain systems with both state and input delays

    Xuanfang YANG; Wuhua CHEN; Huajing FANG


    This paper considers the guaranteed cost control problem for a class of uncertain linear systems with both state and input delays.By representing the time-delay system in the descriptor system form and using a recent result on bounding of cross products of vectors,we obtain new delay-dependent sufficient conditions for the existence of the guaranteed cost controller in terms of linear matrix inequalities.Two examples are presented which show the effectiveness of our approach.

  17. Improving Delay-Range-Dependent Stability Condition for Systems with Interval Time-Varying Delay

    Wei Qian


    Full Text Available This paper discusses the delay-range-dependent stability for systems with interval time-varying delay. Through defining the new Lyapunov-Krasovskii functional and estimating the derivative of the LKF by introducing new vectors, using free matrices and reciprocally convex approach, the new delay-range-dependent stability conditions are obtained. Two well-known examples are given to illustrate the less conservatism of the proposed theoretical results.

  18. Apparatus and Method for Compensating for Process, Voltage, and Temperature Variation of the Time Delay of a Digital Delay Line

    Seefeldt, James (Inventor); Feng, Xiaoxin (Inventor); Roper, Weston (Inventor)


    A process, voltage, and temperature (PVT) compensation circuit and a method of continuously generating a delay measure are provided. The compensation circuit includes two delay lines, each delay line providing a delay output. The two delay lines may each include a number of delay elements, which in turn may include one or more current-starved inverters. The number of delay lines may differ between the two delay lines. The delay outputs are provided to a combining circuit that determines an offset pulse based on the two delay outputs and then averages the voltage of the offset pulse to determine a delay measure. The delay measure may be one or more currents or voltages indicating an amount of PVT compensation to apply to input or output signals of an application circuit, such as a memory-bus driver, dynamic random access memory (DRAM), a synchronous DRAM, a processor or other clocked circuit.

  19. Structure Corrections in Modeling VLBI Delays for RDV Data

    Sovers, Ojars J.; Charlot, Patrick; Fey, Alan L.; Gordon, David


    Since 1997, bimonthly S- and X-band observing sessions have been carried out employing the VLBA (Very Long Baseline Array) and as many as ten additional antennas. Maps of the extended structures have been generated for the 160 sources observed in ten of these experiments (approximately 200,000 observations) taking place during 1997 and 1998. This paper reports the results of the first massive application of such structure maps to correct the modeled VLBI (Very Long Baseline Interferometry) delay in astrometric data analysis. For high-accuracy celestial reference frame work, proper choice of a reference point within each extended source is crucial. Here the reference point is taken at the point of maximum emitted flux. Overall, the weighted delay residuals (approximately equal to 30 ps) are reduced by 8 ps in quadrature upon introducing source maps to model the structure delays of the sources. Residuals of some sources with extended or fast-varying structures improve by as much as 40 ps. Scatter of 'arc positions' about a time-linear model decreases substantially for most sources. Based on our results, it is also concluded that source structure is presently not the dominant error source in astrometric/geodetic VLBI.

  20. Models of the delayed nonlinear Raman response in diatomic gases

    Palastro, J. P.; Antonsen, T. M., Jr.; Pearson, A.


    We examine the delayed response of a diatomic gas to a polarizing laser field with the goal of obtaining computationally efficient methods for use with laser pulse propagation simulations. We demonstrate that for broadband pulses, heavy molecules such as O2 and N2, and typical atmospheric temperatures, the initial delayed response requires only classical physics. The linear kinetic Green's function is derived from the Boltzmann equation and shown to be in excellent agreement with full density-matrix calculations. A straightforward perturbation approach for the fully nonlinear, kinetic impulse response is also presented. With the kinetic theory a reduced fluid model of the diatomic gas’ orientation is derived. Transport coefficients are introduced to model the kinetic phase mixing of the delayed response. In addition to computational rapidity, the fluid model provides intuition through the use of familiar macroscopic quantities. Both the kinetic and the fluid descriptions predict a nonlinear steady-state alignment after passage of the laser pulse, which in the fluid model is interpreted as an anisotropic temperature of the diatomic fluid with respect to motion about the polarization axis.

  1. Advanced access: reducing waiting and delays in primary care.

    Murray, Mark; Berwick, Donald M


    Delay of care is a persistent and undesirable feature of current health care systems. Although delay seems to be inevitable and linked to resource limitations, it often is neither. Rather, it is usually the result of unplanned, irrational scheduling and resource allocation. Application of queuing theory and principles of industrial engineering, adapted appropriately to clinical settings, can reduce delay substantially, even in small practices, without requiring additional resources. One model, sometimes referred to as advanced access, has increasingly been shown to reduce waiting times in primary care. The core principle of advanced access is that patients calling to schedule a physician visit are offered an appointment the same day. Advanced access is not sustainable if patient demand for appointments is permanently greater than physician capacity to offer appointments. Six elements of advanced access are important in its application balancing supply and demand, reducing backlog, reducing the variety of appointment types, developing contingency plans for unusual circumstances, working to adjust demand profiles, and increasing the availability of bottleneck resources. Although these principles are powerful, they are counter to deeply held beliefs and established practices in health care organizations. Adopting these principles requires strong leadership investment and support.

  2. Time Delay for Aerial Ammonia Concentration Measurements in Livestock Buildings

    Rom, Hans Benny; Zhang, Guo-Qiang


    Correct measurements of ammonia concentration in air still present considerable challenges. The high water solubility and polarity can cause it to adsorb on surfaces in the entire sampling system, including sampling lines, filters, valves, pumps and instruments, causing substantial measuring errors and time delays. To estimate time delay characteristics of a Photo Acoustic Multi Gas Monitor 1312 and a Multi Point Sampler continuous measurement of aerial ammonia concentrations at different levels was performed. In order to obtain reproducible data, a wind tunnel was used to generate selected concentrations inside and a background concentration representing the air inlet of the tunnel. Four different concentration levels (0.8 ppm, 6.2 ppm, 9.7 ppm and 13.7 ppm) were used in the experiments, with an additional outdoor concentration level as background. The results indicated a substantial time delay when switching between the measuring positions with high and low concentration and vice versa. These properties may course serious errors for estimation of e.g. gas emissions whenever more than one measuring channel is applied. To reduce the measurement errors, some suggestions regarding design of the measurement setup and measuring strategies were presented. PMID:22399896

  3. Incomplete phase-space method to reveal time delay from scalar time series

    Zhu, Shengli; Gan, Lu


    A computationally quick and conceptually simple method to recover time delay of the chaotic system from scalar time series is developed in this paper. We show that the orbits in the incomplete two-dimensional reconstructed phase-space will show local clustering phenomenon after the component reordering procedure proposed in this work. We find that information captured by the incomplete two-dimensional reconstructed phase-space is related to the time delay τ0 present in the system, and will be transferred to the reordered component by the procedure of component reordering. We then propose the segmented mean variance (SMV) from the reordered component to identify the time delay τ0 of the system. The proposed SMV shows clear maximum when the embedding delay τ of the incomplete reconstruction matches the time delay τ0 of the chaotic system. Numerical data generated by a time-delay system based on the Mackey-Glass equation operating in the chaotic regime are used to illustrate the effectiveness of the proposed SMV. Experimental results show that the proposed SMV is robust to additive observational noise and is able to recover the time delay of the chaotic system even though the amount of data is relatively small and the feedback strength is weak. Moreover, the time complexity of the proposed method is quite low.

  4. Deriving real delay time statistics from the complex delay time statistics in weakly disordered optical media

    Pradhan, Prabhakar; Sahay, Peeyush; Almabadi, Huda M.


    Considering the complex reflection amplitude R=|R|exp(i{\\theta}) of a light wave, real delay time {\\tau}_r (i.e., sojourn or Wigner delay time), which is the energy derivative of the real phase ({\\tau}_r =d{\\theta}/cdk), and complex delay time {\\tau}_i , which is the energy derivative of the reflection coefficient ({\\tau}_i=d{\\theta}_i/cdk, |R|=r^1/2=exp(-{\\theta}_i)), have the same statistical form and a mirror image with a shift in time in weak disorder and short length regime. Real delay t...

  5. Time-Delay Estimation using the Characteristic Roots of Delay Differential Equations

    Sun Yi


    Full Text Available Problem statement: For ordinary dynamic systems (i.e., non-delayed, various methods such as linear least-squares, gradient-weighted least-squares, Kalman filtering and other robust techniques have been widely used in signal processing, robotics, civil engineering. On the other hand, time-delay estimation of systems with unknown time-delay is still a challenging problem due to difficulty in formulation caused. Approach: The presented method makes use of the Lambert W function and analytical solutions of scalar first-order Delay Differential Equations (DDEs. The Lambert W function has been known to be useful in solving delay differential equations. From the solutions in terms of the Lambert W function, the dominant characteristic roots can be obtained and used to estimate time-delays. The function is already embedded in various software packages (e.g., MATLAB and thus, the presented method can be readily used for time-delay systems. Results: The presented method and the provided examples show ease of formulation and accuracy of time-delay estimation. Conclusion: Estimation of time-delays can be conducted in an analytical way. The presented method will be extended to general systems of DDEs and application to physical systems.

  6. Delayed Hopf bifurcation in time-delayed slow-fast systems


    This paper presents an investigation on the phenomenon of delayed bifurcation in time-delayed slow-fast differential systems.Here the two delayed’s have different meanings.The delayed bifurcation means that the bifurcation does not happen immediately at the bifurcation point as the bifurcation parameter passes through some bifurcation point,but at some other point which is above the bifurcation point by an obvious distance.In a time-delayed system,the evolution of the system depends not only on the present state but also on past states.In this paper,the time-delayed slow-fast system is firstly simplified to a slow-fast system without time delay by means of the center manifold reduction,and then the so-called entry-exit function is defined to characterize the delayed bifurcation on the basis of Neishtadt’s theory.It shows that delayed Hopf bifurcation exists in time-delayed slow-fast systems,and the theoretical prediction on the exit-point is in good agreement with the numerical calculation,as illustrated in the two illustrative examples.

  7. Delay-dependent robust H∞ control for uncertain fuzzy hyperbolic systems with multiple delays


    The robust H∞ control problem was considered for a class of fuzzy hyperbolic model (FHM) systems with parametric uncertainties and multiple delays. First, FHM modeling method was presented for time-delay nonlinear systems. Then, by using Lyapunov-Krasovskii approaches, delay-dependent sufficient condition for the existence of a kind of state feedback controller was proposed, which was expressed as linear matrix inequalities (LMIs). The controller can guarantee that the resulting closed-loop system is robustly asymptotically stable with a prescribed H∞ performance level for all admissible uncertainties and time-delay. Finally, a simulation example was provided to illustrate the effectiveness of the proposed approach.

  8. Multivariate Markov processes for stochastic systems with delays: application to the stochastic Gompertz model with delay.

    Frank, T D


    Using the method of steps, we describe stochastic processes with delays in terms of Markov diffusion processes. Thus, multivariate Langevin equations and Fokker-Planck equations are derived for stochastic delay differential equations. Natural, periodic, and reflective boundary conditions are discussed. Both Ito and Stratonovich calculus are used. In particular, our Fokker-Planck approach recovers the generalized delay Fokker-Planck equation proposed by Guillouzic et al. The results obtained are applied to a model for population growth: the Gompertz model with delay and multiplicative white noise.

  9. Delay-dependent criteria for the robust stability of systems with time-varying delay

    Min WU; Yong HE; Jinhua SHE


    The problem of delay-dependent robust stability for systems with titne-varying delay has been considered. By using the S-procedure and the Park' s inequality in the recent issue, a delay-dependent robust stability criterion which is less conservative than the previous results has been derived for time-delay systems with time-varying structured uncertainties. The same idea has also been easily extended to the systems with nonlinear perturbations. Numerical examples illustrated the effectiveness and the improvement of the proposed approach.

  10. Delayed feedback control of time-delayed chaotic systems: Analytical approach at Hopf bifurcation

    Vasegh, Nastaran [Faculty of Electrical Engineering, K.N. Toosi University of Technology, PO Box 16315-1355, Tehran (Iran, Islamic Republic of)], E-mail:; Sedigh, Ali Khaki [Faculty of Electrical Engineering, K.N. Toosi University of Technology, PO Box 16315-1355, Tehran (Iran, Islamic Republic of)


    This Letter is concerned with bifurcation and chaos control in scalar delayed differential equations with delay parameter {tau}. By linear stability analysis, the conditions under which a sequence of Hopf bifurcation occurs at the equilibrium points are obtained. The delayed feedback controller is used to stabilize unstable periodic orbits. To find the controller delay, it is chosen such that the Hopf bifurcation remains unchanged. Also, the controller feedback gain is determined such that the corresponding unstable periodic orbit becomes stable. Numerical simulations are used to verify the analytical results.

  11. Effect of Phase Response Curve Skew on Synchronization with and without Conduction Delays

    Carmen eCanavier


    Full Text Available A central problem in cortical processing including sensory binding and attentional gating is how neurons can synchronize their responses with zero or near-zero time lag. For a spontaneously firing neuron, an input from another neuron can delay or advance the next spike by different amounts depending upon the timing of the input relative to the previous spike. This information constitutes the phase response curve (PRC. We present a simple graphical method for determining the effect of PRC shape on synchronization tendencies and illustrate it using type 1 PRCs, which consist entirely of advances (delays in response to excitation (inhibition. We obtained the following generic solutions for type 1 PRCs, which include the pulse coupled leaky integrate and fire model. For pairs with mutual excitation, exact synchrony can be stable for strong coupling because of the stabilizing effect of the causal limit region of the PRC in which an input triggers a spike immediately upon arrival. However, synchrony is unstable for short delays, because delayed inputs arrive during a refractory period and cannot trigger an immediate spike. Right skew destabilizes antiphase and enables modes with time lags that grow as the conduction delay is increased. Therefore, right skew favors near-synchrony at short conduction delays and a gradual transition between synchrony and antiphase for pairs coupled by mutual excitation. For pairs with mutual inhibition, zero time lag synchrony is stable for conduction delays ranging from zero to a substantial fraction of the period for pairs. However, for right skew there is a preferred antiphase mode at short delays. In contrast to mutual excitation, left skew destabilizes antiphase for mutual inhibition so that synchrony dominates at short delays as well. These pairwise synchronization tendencies constrain the synchronization properties of neurons embedded in larger networks.

  12. PET/CT imaging of delayed radiation encephalopathy following radiotherapy for nasopharyngeal carcinoma

    WANG Xin-lu; YIN Ji-lin; LI Hua; LI Xiang-dong; QUAN Jiang-tao


    Background With the significant improvement in the survival of patients with nasopharyngeal carcinoma (NPC)undergoing radiotherapy and the growing availability of the sophisticated imaging modalities, the number of radiation encephalopathy (RE) cases relating to NPC radiotherapy is increasing. In this study, we investigated the metabolic and density changes of the compromised brain tissues during delayed RE using a positron-emission tomography-computed tomography (PET/CT) to provide clinical evidences for the diagnosis of delayed RE following radiotherapy for NPC.Methods The PET/CT manifestations and the clinical data of 53 pathologically confirmed NPC patients with delayed RE following radical radiotherapy and 15 healthy volunteers were investigated. The standardized uptake values (SUV) of the bilateral temporal lobes, the occipital lobe and the brain stem were measured respectively; and then the metabolic reduction rate of 88 temporal lobes and 13 brain stems were calculated for a statistical comparison between the two groups.Results The earliest case of delayed RE in the investigated patients occurred 1.5 years after radiotherapy. Delayed RE frequently involved the inferior temporal lobe. For patients with delayed RE confirmed by clinical symptoms and imaging findings, PET maintained a 100% coincidence rate with CT; however, in the 25 temporal lobes of the 35 delayed RE patients, PET revealed obvious hypometabolic changes whereas CT displayed normal density. The incidence of brain stem metabolic reductions was 24.5% (13/53) in the investigated patients, including 4 patients with hypometabolic changes shown by PET and negative finding shown by CT. The incidence of granuloma adjacent to the hypometabolic region in the temporal lobe was 12.5% (11/88).Conclusion Delayed RE patients exhibit significant hypometabolic changes in the inferior temporal lobe, captured by PET much earlier than by CT. PET/CT offers a valuable means for the diagnosis of delayed RE in

  13. Impulsive control of time-delay systems using delayed impulse and its application to impulsive master-slave synchronization

    Sun Jitao [Department of Mathematics, Tongji University, Shanghai 200092 (China); Centre for Intelligent and Networked Systems, Central Queensland University, Rockhampton Qld 4702 (Australia); Han Qinglong [Centre for Intelligent and Networked Systems, Central Queensland University, Rockhampton Qld 4702 (Australia); School of Computing Sciences, Central Queensland University, Rockhampton Qld 4702 (Australia)], E-mail:; Jiang Xiefu [Centre for Intelligent and Networked Systems, Central Queensland University, Rockhampton Qld 4702 (Australia); School of Automation, Hangzhou Dianzi University, Hangzhou 310018, Zhejiang (China)


    This Letter is concerned with impulsive control of a class of nonlinear time-delay systems. Some uniform stability criteria for the closed-loop time-delay system under delayed impulsive control are derived by using piecewise Lyapunov functions. Then the criteria are applied to impulsive master-slave synchronization of some secure communication systems with transmission delays and sample delays under delayed impulsive control. Two numerical examples are given to illustrate the effectiveness of the derived results.

  14. The creation of new rotation arc to the rat latissimus dorsi musculo-cutaneous flap with delay procedures

    Aktas Alper


    Full Text Available Abstract Background Latissimus dorsi musculocutaneous flap is one of the most frequently performed reconstructive techniques in surgery. Latissimus dorsi muscle has two arcs of rotation. It is classified as type V muscle. This muscle can be elevated on the thoracodorsal artery to cover large defects in the anterior chest and also, the muscle can be elevated on the segmental vessels to cover midline defects posteriorly. The aim of this study was to create a new arc of rotation on a vertical axis for the muscle and investigate effectiveness of vascular and chemical delays on the latissimus dorsi muscle flap with an inferior pedicle in an experimental rat model. We hypothesized that the latissimus dorsi muscle would be based on inferior pedicle by delay procedures. Methods We tested two different types of delay: vascular and combination of vascular and chemical. We also tried to determine how many days of "delay" can elicit beneficial effects of vascular and combination delays in an inferior pedicled latissimus dorsi musculocutaneous flap. To accomplish this, 48 male Sprague-Dawley rats were randomly subjected to vascular or combination delay (vascular and chemical. In addition, one ear of each rat was assigned into a delay procedure and the other ear was used as a control. Results were evaluated macroscopically, and micro-angiography and histological examinations were also performed. As a result, there was a significant difference in viable flap areas between vascular delay alone and control groups (p Results The higher rate of flap viability was obtained in seven-day vascular delay alone. However, there was no significant difference in the viability between seven-day vascular delay and five-day vascular delay (p Conclusion The combination of vascular and chemical delays increased the rate of viability. Nevertheless, there was no significant difference between vascular delay alone and combination of vascular and chemical delays. Chemical delay did

  15. Engineering Sensorial Delay to Control Phototaxis and Emergent Collective Behaviors

    Mijalkov, Mite; McDaniel, Austin; Wehr, Jan; Volpe, Giovanni


    Collective motions emerging from the interaction of autonomous mobile individuals play a key role in many phenomena, from the growth of bacterial colonies to the coordination of robotic swarms. For these collective behaviors to take hold, the individuals must be able to emit, sense, and react to signals. When dealing with simple organisms and robots, these signals are necessarily very elementary; e.g., a cell might signal its presence by releasing chemicals and a robot by shining light. An additional challenge arises because the motion of the individuals is often noisy; e.g., the orientation of cells can be altered by Brownian motion and that of robots by an uneven terrain. Therefore, the emphasis is on achieving complex and tunable behaviors from simple autonomous agents communicating with each other in robust ways. Here, we show that the delay between sensing and reacting to a signal can determine the individual and collective long-term behavior of autonomous agents whose motion is intrinsically noisy. We experimentally demonstrate that the collective behavior of a group of phototactic robots capable of emitting a radially decaying light field can be tuned from segregation to aggregation and clustering by controlling the delay with which they change their propulsion speed in response to the light intensity they measure. We track this transition to the underlying dynamics of this system, in particular, to the ratio between the robots' sensorial delay time and the characteristic time of the robots' random reorientation. Supported by numerics, we discuss how the same mechanism can be applied to control active agents, e.g., airborne drones, moving in a three-dimensional space. Given the simplicity of this mechanism, the engineering of sensorial delay provides a potentially powerful tool to engineer and dynamically tune the behavior of large ensembles of autonomous mobile agents; furthermore, this mechanism might already be at work within living organisms such as

  16. Stochastic Resonance in a Time-Delayed Bistable System Driven by Square-Wave Signal

    GUO Feng; ZHOU Yu-Rong; ZHANG Yu


    @@ Stochastic resonance in a time-delayed bistable system subject to asymmetric dichotomous noise and multiplica-tire and additive white noise is investigated.Using small time delay approximation,we obtain the expression of the signal-to-noise ratio (SNR).It is found that the SNR is a non-monotonic function of the delayed times,of the amplitude of the input square-wave signal,as well as of the asymmetry of the dichotomous noise.In addition,the SNR varies non-monotonously with the system parameters,with the intensities of the multiplicative and additive noise,as well as with the correlate rate of the dichotomous noise.

  17. Delay Differential Analysis of Time Series

    Lainscsek, Claudia; Sejnowski, Terrence J.


    Nonlinear dynamical system analysis based on embedding theory has been used for modeling and prediction, but it also has applications to signal detection and classification of time series. An embedding creates a multidimensional geometrical object from a single time series. Traditionally either delay or derivative embeddings have been used. The delay embedding is composed of delayed versions of the signal, and the derivative embedding is composed of successive derivatives of the signal. The delay embedding has been extended to nonuniform embeddings to take multiple timescales into account. Both embeddings provide information on the underlying dynamical system without having direct access to all the system variables. Delay differential analysis is based on functional embeddings, a combination of the derivative embedding with nonuniform delay embeddings. Small delay differential equation (DDE) models that best represent relevant dynamic features of time series data are selected from a pool of candidate models for detection or classification. We show that the properties of DDEs support spectral analysis in the time domain where nonlinear correlation functions are used to detect frequencies, frequency and phase couplings, and bispectra. These can be efficiently computed with short time windows and are robust to noise. For frequency analysis, this framework is a multivariate extension of discrete Fourier transform (DFT), and for higher-order spectra, it is a linear and multivariate alternative to multidimensional fast Fourier transform of multidimensional correlations. This method can be applied to short or sparse time series and can be extended to cross-trial and cross-channel spectra if multiple short data segments of the same experiment are available. Together, this time-domain toolbox provides higher temporal resolution, increased frequency and phase coupling information, and it allows an easy and straightforward implementation of higher-order spectra across time

  18. Different delays-induced regime shifts in a stochastic insect outbreak dynamics

    Zeng, Jiakui; Zeng, Chunhua; Xie, Qingshuang; Guan, Lin; Dong, Xiaohui; Yang, Fengzao


    Considering time delays in the deterministic and stochastic forces, we construct stochastic delayed differential equations to investigate the regime shifts in an insect ecosystem. The stationary probability distribution (SPD) and mean first passage time (MFPT) are obtained, respectively. Our main results show: (i) The multiplicative noise, positive cross-correlation noise between two noises and time delays can induce the regime shifts from the boom outbreak state to the bust one, but the additive noise and negative cross-correlation can induce the regime shifts from the bust outbreak state to the boom one; (ii) For the negative cross-correlation, the MFPT as a function of noise strengths exhibits one maximum, which shows the characteristic of the noise-delayed switching for the boom outbreak state, but for the no cross-correlation or positive cross-correlation, the MFPT decreases with the noise strengths; (iii) Two different types of time delays play same roles on the maximal MFPT with additive noise, and play opposite roles on the maximal MFPT with multiplicative noise. The mechanisms for noises-and delays-induced regime shifts between two states can be explained physically through the effective potential of ecological model.

  19. Pubertal growth of the medial amygdala delayed by short photoperiods in the Siberian hamster, Phodopus sungorus.

    Cooke, Bradley M; Jordan, Cynthia L; Breedlove, S Marc


    We investigated whether puberty influences the morphology of the medial nucleus of the amygdala (MeA) by comparing Siberian hamsters (Phodopus sungorus) that had been raised from birth in either long day (LD; 16:8 h light:dark) or short day (SD; 8:16) photoperiods. Hamsters were sacrificed at 42-49 days of age, at which point all LD hamsters were reproductively mature, as evidenced by adult-like testes weights (mean: 657 mg). In contrast, the testes weights of the SD hamsters were low (mean: 31 mg), indicating that the SD photoperiod had delayed puberty. The regional volume and mean soma size of the four MeA subnuclei was estimated bilaterally by stereological procedures. In the posterior dorsal and ventral MeA subnuclei, regional volume was 22-25% larger, and mean soma size 18% larger, in LD males than SD males. Unbiased cell counts in the posterior dorsal MeA showed that LD and SD hamsters have equivalent neuron numbers. In the anterior MeA subnuclei, regional volumes and soma sizes from LD and SD hamsters were equivalent. Additionally, the regional volume of the posteroventral subnucleus was larger in the right hemisphere than the left, but this laterality did not respond to photoperiod manipulation. These results suggest that the extant neurons within the posterior MeA, a steroid-sensitive nucleus implicated in socio-sexual behavior, grow in response to the elevated levels of circulating androgen accompanying puberty, and that photoperiodic regulation of puberty affects morphological maturation of this nucleus.

  20. β-delayed proton decays near the proton drip line

    XU; Shuwei; LI; Zhankui; XIE; Yuanxiang; HUANG; Wenxue; SH


    We briefly reviewed the experimental study on β-delayed proton decays near the proton drip line published by our group during the period of 1996―2004, namely the first observation of the β-delayed proton decays of 9 new nuclides in the rare-earth region and the new measurements of β-delayed proton decays of 5 nuclides in the mass (90 region near the N = Z line with the aid of the "p-γ" coincidence in combination with a He-jet tape transport system. In the meantime some important experimental technique details were supplemented. The experimental results, including the half-lives, spins, parities, deformations and production reaction cross sections for the 14 nuclei were summarized and compared with the current nuclear-model predictions, and then the following points were represented. (1) The experimental half-lives for 85Mo and 92Rh as well as the predicted "waiting point" nuclei 89Ru and 93Pd are 5―10 times longer than the theoretical predictions given by M(o)ller et al. using a macroscopic-microscopic model. It considerably influences the predictions of the abundances of the nuclides produced in the rp-process. (2) The current-model predictions are not consistent with the experimental assignments of the spins and parities for the proton drip-line nuclei 142Ho and 128Pm. However, the nuclear potential energy surface (PES) calculated by using a Woods- Saxon-Strutinsky method reproduced the experimental results. (3) The Alice code overestimated the production reaction cross sections of the studied 9 rare-earth nuclei by one order of magnitude or two, while HIVAP code overestimated them by one order of magnitude approximately.

  1. The delay effect on outcome evaluation: results from an Event-related Potential study

    Chen eQu


    Full Text Available Behavioral studies demonstrate that the timing of receiving gains or losses affects decision-making, a phenomenon known as temporal discounting, as participants are inclined to prefer immediate rewards over delayed ones and vice versa for losses. The present study used the event-related potential (ERP technique with a simple gambling task to investigate how delayed rewards and losses affected the brain activity in outcome evaluations made by 20 young adults. Statistical analysis revealed a larger feedback related negativity (FRN effect between loss and gain following immediate outcomes than following future outcomes. In addition, delay impacted FRN only in gain conditions, with delayed winning eliciting a more negative FRN than immediatewinning. These results suggest that temporal discounting and sign effect could be encoded in the FRN in the early stage of outcome evaluation.

  2. State Feedback Consensus for Multi-Agent System with Multiple Time-Delays

    Jia Wei


    Full Text Available In this paper, we study the multi-agent system to achieve a faster consensus with multiple time-delays under a directed asymmetric information exchange topology. We first assume that an agent processes its own state information with self-delay and receives state information from its neighbors with communication delays. Based on state proportion derivative feedback, the improved consensus protocol can accelerate the system to achieve a consensus. A sufficient condition for reaching consensus is then derived based on the Nyquist stability criterion and frequency domain analysis. In addition, a specific form of consensus equilibrium is obtained which is influenced by the initial states of agents, time-delays and state feedback intensity. Finally, simulations are presented to verify the validity of the theoretical results.

  3. D-leaping: Accelerating stochastic simulation algorithms for reactions with delays

    Bayati, Basil; Chatelain, Philippe; Koumoutsakos, Petros


    We propose a novel, accelerated algorithm for the approximate stochastic simulation of biochemical systems with delays. The present work extends existing accelerated algorithms by distributing, in a time adaptive fashion, the delayed reactions so as to minimize the computational effort while preserving their accuracy. The accuracy of the present algorithm is assessed by comparing its results to those of the corresponding delay differential equations for a representative biochemical system. In addition, the fluctuations produced from the present algorithm are comparable to those from an exact stochastic simulation with delays. The algorithm is used to simulate biochemical systems that model oscillatory gene expression. The results indicate that the present algorithm is competitive with existing works for several benchmark problems while it is orders of magnitude faster for certain systems of biochemical reactions.

  4. Effect of Boron on Delayed Fracture Resistance of Medium-Carbon High Strength Spring Steel


    The delayed fracture behavior of medium-carbon high strength spring steel containing different amounts of boron (0. 000 5%, 0. 001 6%) was studied using sustained load delayed fracture test. The results show that delayed fracture resistance of boron containing steels is higher than that of conventional steel 60Si2MnA at the same strength level and it increases with the increase of boron content from 0. 000 5 % to 0. 001 6 %. The delayed fracture mode is mainly intergranular in the boron containing steels tempered at 350 ℃, which indicates that the addition of boron does not change the fracture character. However, the increase of boron content enlarges the size of the crack initiation area. Further study of phase analysis indicates that most boron is in solid solution, and only a very small quantity of boron is in the M3 (C, B) phase.

  5. Modulating resonance behaviors by noise recycling in bistable systems with time delay

    Sun, Zhongkui, E-mail:; Xu, Wei [Department of Applied Mathematics, Northwestern Polytechnical University, Xi' an 710072 (China); Yang, Xiaoli [College of Mathematics and Information Science, Shaan' xi Normal University, Xi' an 710062 (China); Xiao, Yuzhu [Department of Mathematics and Information Science, Chang' an University, Xi' an 710086 (China)


    In this paper, the impact of noise recycling on resonance behaviors is studied theoretically and numerically in a prototypical bistable system with delayed feedback. According to the interior cooperating and interacting activity of noise recycling, a theory has been proposed by reducing the non-Markovian problem into a two-state model, wherein both the master equation and the transition rates depend on not only the current state but also the earlier two states due to the recycling lag and the feedback delay. By virtue of this theory, the formulae of the power spectrum density and the linear response function have been found analytically. And the theoretical results are well verified by numerical simulations. It has been demonstrated that both the recycling lag and the feedback delay play a crucial role in the resonance behaviors. In addition, the results also suggest an alternative scheme to modulate or control the coherence or stochastic resonance in bistable systems with time delay.

  6. Complex synchronous behavior in interneuronal networks with delayed inhibitory and fast electrical synapses

    Guo, Daqing; Wang, Qingyun; Perc, Matjaž


    Networks of fast-spiking interneurons are crucial for the generation of neural oscillations in the brain. Here we study the synchronous behavior of interneuronal networks that are coupled by delayed inhibitory and fast electrical synapses. We find that both coupling modes play a crucial role by the synchronization of the network. In addition, delayed inhibitory synapses affect the emerging oscillatory patterns. By increasing the inhibitory synaptic delay, we observe a transition from regular to mixed oscillatory patterns at a critical value. We also examine how the unreliability of inhibitory synapses influences the emergence of synchronization and the oscillatory patterns. We find that low levels of reliability tend to destroy synchronization and, moreover, that interneuronal networks with long inhibitory synaptic delays require a minimal level of reliability for the mixed oscillatory pattern to be maintained.

  7. The pathophysiologic aspects and clinical implications of electrocardiographic parameters of ventricular conduction delay in repaired tetralogy of Fallot.

    Udink ten Cate, Floris E A; Sreeram, Narayanswami; Brockmeier, Konrad


    The 12-lead surface electrocardiogram is a valuable and feasible clinical tool in the management of patients following tetralogy of Fallot (TOF) repair. The importance of QRS duration in TOF patients has long been acknowledged. A prolonged QRS complex has been associated with increased risk for subsequent life-threatening ventricular arrhythmia and sudden cardiac death. Our current ability to risk-stratify TOF patients for malignant arrhythmogenic events primarily on the basis of QRS duration is rather limited. Nevertheless, increasing evidence suggests that QRS morphology and duration may be useful as surrogate markers of infundibular and regional right ventricular myocardial disease. The aim of this review is to provide a critical appraisal of the clinical implications of established and new electrocardiographic markers of ventricular conduction delay in TOF patients following surgical correction with a particular focus on QRS duration, lengthening, and fragmentation. In addition, the pathophysiological background of these parameters is addressed.

  8. Management and associated factors of delayed perforation after gastric endoscopic submucosal dissection

    Suzuki, Haruhisa; Oda, Ichiro; Sekiguchi, Masau; Abe, Seiichiro; Nonaka, Satoru; Yoshinaga, Shigetaka; Nakajima, Takeshi; Saito, Yutaka


    AIM: To identify the actual clinical management and associated factors of delayed perforation after gastric endoscopic submucosal dissection (ESD). METHODS: A total of 4943 early gastric cancer (EGC) patients underwent ESD at our hospital between January 1999 and June 2012. We retrospectively assessed the actual management of delayed perforation. In addition, to determine the factors associated with delayed perforation, after excluding 123 EGC patients with perforations that occurred during the ESD procedure, we analyzed the following clinicopathological factors among the remaining 4820 EGC patients by comparing the ESD cases with delayed perforation and the ESD cases without perforation: age, sex, chronological periods, clinical indications for ESD, status of the stomach, location, gastric circumference, tumor size, invasion depth, presence/absence of ulceration, histological type, type of resection, and procedure time. RESULTS: Delayed perforation occurred in 7 (0.1%) cases. The median time until the occurrence of delayed perforation was 11 h (range, 6-172 h). Three (43%) of the 7 cases required emergency surgery, while four were conservatively managed without surgical intervention. Among the 4 cases with conservative management, 2 were successfully managed endoscopically using the endoloop-endoclip technique. The median hospital stay was 18 d (range, 15-45 d). There were no delayed perforation-related deaths. Based on a multivariate analysis, gastric tube cases (OR = 11.0; 95%CI: 1.7-73.3; P = 0.013) were significantly associated with delayed perforation. CONCLUSION: Endoscopists must be aware of not only the identified factors associated with delayed perforation, but also how to treat this complication effectively and promptly. PMID:26640340

  9. The diffusive Lotka-Volterra predator-prey system with delay.

    Al Noufaey, K S; Marchant, T R; Edwards, M P


    Semi-analytical solutions for the diffusive Lotka-Volterra predator-prey system with delay are considered in one and two-dimensional domains. The Galerkin method is applied, which approximates the spatial structure of both the predator and prey populations. This approach is used to obtain a lower-order, ordinary differential delay equation model for the system of governing delay partial differential equations. Steady-state and transient solutions and the region of parameter space, in which Hopf bifurcations occur, are all found. In some cases simple linear expressions are found as approximations, to describe steady-state solutions and the Hopf parameter regions. An asymptotic analysis for the periodic solution near the Hopf bifurcation point is performed for the one-dimensional domain. An excellent agreement is shown in comparisons between semi-analytical and numerical solutions of the governing equations.

  10. Theory of attosecond delays in molecular photoionization

    Baykusheva, Denitsa; Wörner, Hans Jakob


    We present a theoretical formalism for the calculation of attosecond delays in molecular photoionization. It is shown how delays relevant to one-photon-ionization, also known as Eisenbud-Wigner-Smith delays, can be obtained from the complex dipole matrix elements provided by molecular quantum scattering theory. These results are used to derive formulae for the delays measured by two-photon attosecond interferometry based on an attosecond pulse train and a dressing femtosecond infrared pulse. These effective delays are first expressed in the molecular frame where maximal information about the molecular photoionization dynamics is available. The effects of averaging over the emission direction of the electron and the molecular orientation are introduced analytically. We illustrate this general formalism for the case of two polyatomic molecules. N2O serves as an example of a polar linear molecule characterized by complex photoionization dynamics resulting from the presence of molecular shape resonances. H2O illustrates the case of a non-linear molecule with comparably simple photoionization dynamics resulting from a flat continuum. Our theory establishes the foundation for interpreting measurements of the photoionization dynamics of all molecules by attosecond metrology.

  11. Wigner photoemission time delay from endohedral anions

    Kumar, Ashish; Varma, Hari R.; Deshmukh, Pranawa C.; Manson, Steven T.; Dolmatov, Valeriy K.; Kheifets, Anatoli


    Characteristic features of Wigner photoemission time delay from endohedral anions A@C60q along with their dependence on the anion charge q are unraveled. Specifically, significant enhancement of the time delay in the innermost dipole photoionization channels near threshold is found, owing to the presence of the Coulomb confined resonances (CRs). Moreover, it is shown that interchannel coupling of the inner-shell Coulomb CRs with outer-shell photoionization channels results in resonantly enhanced time delay in the release of the outer-shell photoelectron well above, several hundreds eV, the outer-shell thresholds. It is also demonstrated that, and explained why, photoionization cross sections of the innermost subshells as well as outer subshells (near the inner-subshell threshold) depends only very weakly on the anion charge q , but the dependence of the corresponding time delays on q can be significant. Furthermore, Coulomb CRs are found to emerge in the innermost quadrupole photoionization channels as well, thereby causing considerable time delay in the quadrupole photoemission. These findings are illustrated in calculations of the photoionization of inner and outer subshells of the endohedral anions Ne@C60-1 and Ne@C60-5 that were chosen as case studies.

  12. Putative sugarcane FT/TFL1 genes delay flowering time and alter reproductive architecture in Arabidopsis

    Coelho, Carla P.; Minow, Mark A. A.; Chalfun-Júnior, Antonio; Colasanti, Joseph


    Agriculturally important grasses such as rice, maize, and sugarcane are evolutionarily distant from Arabidopsis, yet some components of the floral induction process are highly conserved. Flowering in sugarcane is an important factor that negatively affects cane yield and reduces sugar/ethanol production from this important perennial bioenergy crop. Comparative studies have facilitated the identification and characterization of putative orthologs of key flowering time genes in sugarcane, a complex polyploid plant whose genome has yet to be sequenced completely. Using this approach we identified phosphatidylethanolamine-binding protein (PEBP) gene family members in sugarcane that are similar to the archetypical FT and TFL1 genes of Arabidopsis that play an essential role in controlling the transition from vegetative to reproductive growth. Expression analysis of ScTFL1, which falls into the TFL1-clade of floral repressors, showed transcripts in developing leaves surrounding the shoot apex but not at the apex itself. ScFT1 was detected in immature leaves and apical regions of vegetatively growing plants and, after the floral transition, expression also occurred in mature leaves. Ectopic over-expression of ScTFL1 in Arabidopsis caused delayed flowering in Arabidopsis, as might be expected for a gene related to TFL1. In addition, lines with the latest flowering phenotype exhibited aerial rosette formation. Unexpectedly, over-expression of ScFT1, which has greatest similarity to the florigen-encoding FT, also caused a delay in flowering. This preliminary analysis of divergent sugarcane FT and TFL1 gene family members from Saccharum spp. suggests that their expression patterns and roles in the floral transition has diverged from the predicted role of similar PEBP family members. PMID:24904616

  13. Putative sugarcane FT/TFL1 genes delay flowering time and alter reproductive architecture in Arabidopsis.

    Coelho, Carla P; Minow, Mark A A; Chalfun-Júnior, Antonio; Colasanti, Joseph


    Agriculturally important grasses such as rice, maize, and sugarcane are evolutionarily distant from Arabidopsis, yet some components of the floral induction process are highly conserved. Flowering in sugarcane is an important factor that negatively affects cane yield and reduces sugar/ethanol production from this important perennial bioenergy crop. Comparative studies have facilitated the identification and characterization of putative orthologs of key flowering time genes in sugarcane, a complex polyploid plant whose genome has yet to be sequenced completely. Using this approach we identified phosphatidylethanolamine-binding protein (PEBP) gene family members in sugarcane that are similar to the archetypical FT and TFL1 genes of Arabidopsis that play an essential role in controlling the transition from vegetative to reproductive growth. Expression analysis of ScTFL1, which falls into the TFL1-clade of floral repressors, showed transcripts in developing leaves surrounding the shoot apex but not at the apex itself. ScFT1 was detected in immature leaves and apical regions of vegetatively growing plants and, after the floral transition, expression also occurred in mature leaves. Ectopic over-expression of ScTFL1 in Arabidopsis caused delayed flowering in Arabidopsis, as might be expected for a gene related to TFL1. In addition, lines with the latest flowering phenotype exhibited aerial rosette formation. Unexpectedly, over-expression of ScFT1, which has greatest similarity to the florigen-encoding FT, also caused a delay in flowering. This preliminary analysis of divergent sugarcane FT and TFL1 gene family members from Saccharum spp. suggests that their expression patterns and roles in the floral transition has diverged from the predicted role of similar PEBP family members.

  14. Putative sugarcane FT/TFL1 genes delay flowering time and alter reproductive architecture in Arabidopsis

    Carla P. Coelho


    Full Text Available Agriculturally important grasses such as rice, maize and sugarcane are evolutionarily distant from Arabidopsis, yet some components of the floral induction process are highly conserved. Flowering in sugarcane is an important factor that negatively affects cane yield and reduces sugar/ethanol production from this important perennial bioenergy crop. Comparative studies have facilitated the identification and characterization of putative orthologs of key flowering time genes in sugarcane, a complex polyploid plant whose genome has yet to be sequenced completely. Using this approach we identified phosphatidylethanolamine-binding protein (PEBP gene family members in sugarcane that are similar to the archetypical FT and TFL1 genes of Arabidopsis that play an essential role in controlling the transition from vegetative to reproductive growth. Expression analysis of ScTFL1, which falls into the TFL1-clade of floral repressors, showed transcripts in developing leaves surrounding the shoot apex but not at the apex itself. ScFT1 was detected in immature leaves and apical regions of vegetatively growing plants and, after the floral transition, expression also occurred in mature leaves. Ectopic over-expression of ScTFL1 in Arabidopsis caused delayed flowering in Arabidopsis, as might be expected for a gene related to TFL1. In addition, lines with the latest flowering phenotype exhibited aerial rosette formation. Unexpectedly, over-expression of ScFT1, which has greatest similarity to the florigen-encoding FT, also caused a delay in flowering. This preliminary analysis of divergent sugarcane FT and TFL1 gene family members from Saccharum spp. suggests that their expression patterns and roles in the floral transition has diverged from the predicted role of similar PEBP family members.

  15. Delay-Dependent Exponential Stability Criterion for BAM Neural Networks with Time-Varying Delays

    Wei-Wei Su; Yi-Ming Chen


    By employing the Lyapunov stability theory and linear matrix inequality (LMI) technique, delay dependent stability criterion is derived to ensure the exponential stability of bi-directional associative memory (BAM) neural networks with time-varying delays. The proposed condition can be checked easily by LMI control toolbox in Matlab. A numerical example is given to demonstrate the effectiveness of our results.


    Niu Yuanling; Zhang Chengjian; Duan Jinqiao


    A type of complex systems under both random influence and memory effects is considered.The systems are modeled by a class of nonlinear stochastic delay-integrodifferential equations.A delay-dependent stability criterion for such equations is derived under the condition that the time lags are small enough.Numerical simulations are presented to illustrate the theoretical result.

  17. The Effects of Delay of Feedback on a Delayed Concept Formation Transfer Task.

    Schroth, Marvin L.


    Delay and completeness of verbal information feedback were investigated within a transfer of learning paradigm involving concept formation. An experiment with 192 undergraduates indicates that, although delay of feedback (up to 30 seconds) slows speed of learning on the initial task, it has positive effects on the transfer task. (SLD)

  18. Effect of Delay on Children's Delay-Execute Prospective Memory Performance

    Rendell, Peter G.; Vella, Melissa J.; Kliegel, Matthias; Terrett, Gill


    To date, little work has been done investigating prospective memory in children, particularly using a delay-execute paradigm. Two experiments were conducted to investigate this issue with children aged 5-11 years. While playing a computer driving game, children's ability to carry out a delayed intention either immediately a target cue appeared or…

  19. Robust delay-dependent feedforward control of neutral time-delay systems via dynamic IQCs

    Ucun, L.; Küçükdemiral, I. B.


    This paper studies the design problem of delay-dependent ? based robust and optimal feedforward controller design for a class of time-delay control systems having state, control and neutral type delays which are subject to norm-bounded uncertainties and ? type measurable or observable disturbance signals. Two independent loops which include state-feedback and dynamic feedforward controller form the basis of the proposed control scheme in this study. State-feedback controller is generally used in stabilisation of the nominal delay-free system, whereas the feedforward controller is used for improving disturbance attenuation performance of the overall system. In order to obtain less conservative results, the delay and parametric uncertainty effects are treated in operator view point and represented by frequency-dependent (dynamic) integral quadratic constraints (IQCs). Moreover, sufficient delay-dependent criterion is developed in terms of linear matrix inequalities (LMIs) such that the time-delay system having parametric uncertainties is guaranteed to be asymptotically stable with minimum achievable disturbance attenuation level. Plenty of numerical examples are provided at the end, in order to illustrate the efficiency of the proposed technique. The achieved results on minimum achievable disturbance attenuation level and maximum allowable delay bounds are exhibited to be less conservative in comparison to those of controllers having only feedback loop.

  20. A Comparison of Motor Delays in Young Children: Autism Spectrum Disorder, Developmental Delay, and Developmental Concerns

    Provost, Beth; Lopez, Brian R.; Heimerl, Sandra


    This study assessed motor delay in young children 21-41 months of age with autism spectrum disorder (ASD), and compared motor scores in children with ASD to those of children without ASD. Fifty-six children (42 boys, 14 girls) were in three groups: children with ASD, children with developmental delay (DD), and children with developmental concerns…

  1. Controllability of Linear Discrete-Time Systems with Both Delayed States and Delayed Inputs

    Hong Shi


    Full Text Available The controllability issues for discrete-time linear systems with delay in state and control are addressed. By introducing a new concept, the controllability realization index (CRI, the characteristic of controllability is revealed. An easily testable necessary and sufficient condition for the controllability of discrete-time linear systems with state and control delay is established.

  2. Delayed feedback control in quantum transport.

    Emary, Clive


    Feedback control in quantum transport has been predicted to give rise to several interesting effects, among them quantum state stabilization and the realization of a mesoscopic Maxwell's daemon. These results were derived under the assumption that control operations on the system are affected instantaneously after the measurement of electronic jumps through it. In this contribution, I describe how to include a delay between detection and control operation in the master equation theory of feedback-controlled quantum transport. I investigate the consequences of delay for the state stabilization and Maxwell's daemon schemes. Furthermore, I describe how delay can be used as a tool to probe coherent oscillations of electrons within a transport system and how this formalism can be used to model finite detector bandwidth.

  3. Delay estimation for CMOS functional cells

    Madsen, Jan


    Presents a new RC tree network model for delay estimation of CMOS functional cells. The model is able to reflect topological changes within a cell, which is of particular interest when doing performance driven layout synthesis. Further, a set of algorithms to perform worst case analysis on arbitr......Presents a new RC tree network model for delay estimation of CMOS functional cells. The model is able to reflect topological changes within a cell, which is of particular interest when doing performance driven layout synthesis. Further, a set of algorithms to perform worst case analysis...... on arbitrary CMOS functional cells using the proposed delay model, is presented. Both model and algorithms have been implemented as a part of a cell compiler (CELLO) working in an experimental silicon compiler environment....

  4. Why do delayed summaries improve metacomprehension accuracy?

    Anderson, Mary C M; Thiede, Keith W


    We showed that metacomprehension accuracy improved when participants (N=87 college students) wrote summaries of texts prior to judging their comprehension; however, accuracy only improved when summaries were written after a delay, not when written immediately after reading. We evaluated two hypotheses proposed to account for this delayed-summarization effect (the accessibility hypothesis and the situation model hypothesis). The data suggest that participants based metacomprehension judgments more on the gist of texts when they generated summaries after a delay; whereas, they based judgments more on details when they generated summaries immediately after reading. Focusing on information relevant to the situation model of a text (the gist of a text) produced higher levels of metacomprehension accuracy, which is consistent with situation model hypothesis.

  5. Opportunistic Secrecy with a Strict Delay Constraint

    Khalil, Karim; Gamal, Hesham El; Youssef, Moustafa


    We investigate the delay limited secrecy capacity of the flat fading channel under two different assumptions on the available transmitter channel state information (CSI). The first scenario assumes perfect prior knowledge of both the main and eavesdropper channel gains. Here, upper and lower bounds on the delay limited secrecy capacity are derived, and shown to be tight in the high signal-to-noise ratio (SNR) regime. In the second scenario, only the main channel CSI is assumed to be available at the transmitter where, remarkably, we establish the achievability of a non-zero delay-limited secure rate, for a wide class of channel distributions, with a high probability. In the two cases, our achievability arguments are based on a novel two-stage key-sharing approach that overcomes the secrecy outage phenomenon observed in earlier works.

  6. Reasons for diagnostic delay in gynecological malignancies

    Vandborg, Mai Partridge; Christensen, René dePont Christensen; Kragstrup, Jakob;


    Aim The primary aim of this study was to identify and describe different delay types in women with gynecologic cancer, and to analyze the relationship between diagnostic delay and a number of characteristics for patients, cancers and the health care system. Setting A cohort study of women newly...... diagnosed with gynecological cancer at the Department of Gynecology and Obstetrics at Odense University Hospital (OUH) Denmark, during a 15-month period from October 1st 2006 to December 31st 2007. Method Data were obtained from four different questionnaires, the Electronic Patient Journal (EPJ......) and The Danish Gynecological Cancer Database (DGCD). 161 women were included; ovarian cancer: 63, endometrial cancer: 50, cervical cancer: 34 and vulvar cancer: 14. Outcome measures were different delay types counted in days and the influence of four clinical important variables: Presence of alarm symptoms, age...

  7. Abdominal CT findings of delayed postoperative complications

    Zissin, R.; Osadchy, A. [Sapir Medical Center, Dept. of Diagnostic Imaging, Kfar Saba (Israel)]. E-mail:; Gayer, G. [Assaf Harofe Medical Center, Dept. of Diagnostic Imaging, Zrifin (Israel)


    Despite progress in surgical techniques and modern medical treatment, postoperative complications occur not infrequently and vary according to type of surgery, clinical setting, and time elapsed since surgery. In general, they can be divided into early and delayed complications. Delayed postoperative complications can be classified as specific and nonspecific. The common nonspecific delayed complications are incisional hernia and postoperative bowel obstruction. Bowel obstruction can be further categorized as obstruction related to benign or neoplastic etiology, the latter occurring in oncology patients in whom the primary surgery was related to an underlying abdominal neoplasm. Gossypiboma is another, fortunately rare, postoperative complication. Specific complications appear after specific operations and include the following: Splenosis - following splenectomy. Retained gallstones and spilled gallstones - following cholecystectomy, mainly laparoscopic. Dropped appendicolith and stump appendicitis - following appendectomy, mainly laparoscopic. Obturation obstruction by a bezoar - following gastric surgery. Afferent loop syndrome (ALS) - following Bilroth II gastrectomy. (author)

  8. Delayed reconstruction of a quadriceps tendon.

    Pocock, C A J; Trikha, S P; Bell, J S P


    Rupture of the quadriceps tendon is an uncommon injury and rapid diagnosis is important because delay in surgical repair generally is believed to adversely affect outcome. One study of 20 patients suggests repair should be done during the first 48 to 72 hours postinjury to achieve a successful outcome and late repair led to unsatisfactory recovery. Cases of delayed tendon repair have been reported, the longest to our knowledge being 11 months before surgical intervention. We present a case of successful outcome of a quadriceps tendon rupture reconstructed at least 8 years after occurrence and a review of the literature of delayed reconstructions. We show that successful restoration of extensor mechanism function can be achieved several years after tendon rupture.

  9. Time-delayed autosynchronous swarm control.

    Biggs, James D; Bennet, Derek J; Dadzie, S Kokou


    In this paper a general Morse potential model of self-propelling particles is considered in the presence of a time-delayed term and a spring potential. It is shown that the emergent swarm behavior is dependent on the delay term and weights of the time-delayed function, which can be set to induce a stationary swarm, a rotating swarm with uniform translation, and a rotating swarm with a stationary center of mass. An analysis of the mean field equations shows that without a spring potential the motion of the center of mass is determined explicitly by a multivalued function. For a nonzero spring potential the swarm converges to a vortex formation about a stationary center of mass, except at discrete bifurcation points where the center of mass will periodically trace an ellipse. The analytical results defining the behavior of the center of mass are shown to correspond with the numerical swarm simulations.

  10. Elimination of Delays to Oculomotor Research Equipment

    Saulius Niauronis


    Full Text Available Optic stimulus used for human oculomotor system or eye-hand coordination researches is often represented on a computer screen. They must be synchronised with the eye tracker to achieve the accurate results of the conducted experiments. Relation between stimulus presence and eye image capturing times can be defined only with reference to knowledge of all system delays. The suggested research evaluates our eye tracking system delay and propose a practical method for measuring and evaluating delays to the computer graphic subsystem. Experimental research shows that LC Technologies eye tracker reports gaze angle with 28 ms lag and the average stimulus lag of the computer graphic subsystem is 9,5 ms.Article in Lithuanian

  11. Time delay measurement in the frequency domain

    Durbin, Stephen M., E-mail:; Liu, Shih-Chieh [Purdue University, West Lafayette, IN 47907 (United States); Dufresne, Eric M.; Li, Yuelin; Wen, Haidan [Argonne National Laboratory, Argonne, IL 60439 (United States)


    A simple frequency domain technique for determining the time delay between laser pump and X-ray probe pulses achieves 1 ps resolution even for ∼100 ps synchrotron pulses, permitting improved pump–probe characterization of ultrafast processes. Pump–probe studies at synchrotrons using X-ray and laser pulses require accurate determination of the time delay between pulses. This becomes especially important when observing ultrafast responses with lifetimes approaching or even less than the X-ray pulse duration (∼100 ps). The standard approach of inspecting the time response of a detector sensitive to both types of pulses can have limitations due to dissimilar pulse profiles and other experimental factors. Here, a simple alternative is presented, where the frequency response of the detector is monitored versus time delay. Measurements readily demonstrate a time resolution of ∼1 ps. Improved precision is possible by simply extending the data acquisition time.

  12. Linear delay-differential systems with commensurate delays an algebraic approach

    Gluesing-Luerssen, Heide


    The book deals with linear time-invariant delay-differential equations with commensurated point delays in a control-theoretic context. The aim is to show that with a suitable algebraic setting a behavioral theory for dynamical systems described by such equations can be developed. The central object is an operator algebra which turns out to be an elementary divisor domain and thus provides the main tool for investigating the corresponding matrix equations. The book also reports the results obtained so far for delay-differential systems with noncommensurate delays. Moreover, whenever possible it points out similarities and differences to the behavioral theory of multidimensional systems, which is based on a great deal of algebraic structure itself. The presentation is introductory and self-contained. It should also be accessible to readers with no background in delay-differential equations or behavioral systems theory. The text should interest researchers and graduate students.

  13. Delay-dependent stability and stabilization criteria of networked control systems with multiple time-delays

    Huaicheng YAN; Xinhan HUANG; Min WANG


    This paper deals with the problem of delay-dependent stability and stabilization for networked control systems(NCSs)with multiple time-delays. In view of multi-input and multi-output(MIMO) NCSs with many independent sensors and actuators, a continuous time model with distributed time-delays is proposed. Utilizing the Lyapunov stability theory combined with linear matrix inequalities(LMIs) techniques, some new delay-dependent stability criteria for NCSs in terms of generalized Lyapunov matrix equation and LMIs are derived. Stabilizing controller via state feedback is formulated by solving a set of LMIs. Compared with the reported methods, the proposed methods give a less conservative delay bound and more general results. Numerical example and simulation show that the methods are less conservative and more effective.

  14. Delay-dependent robust stability of uncertain networked control systems with multiple state time-delays

    Huaicheng YAN; Xinhan HUANG; Min WANG


    In this paper, delay-dependent robust stability for a class of uncertain networked control systems (NCSs)with multiple state time-delays is investigated. Modeling of multi-input and multi-output (MIMO) NCSs with networkinduced delays and uncertainties through new methods are proposed. Some new stability criteria in terms of LMIs are derived by using Lyapunov stability theory combined with linear matrix inequalities (LMIs) techniques. We analyze the delay-dependent asymptotic stability and obtain maximum allowable delay bound (MADB) for the NCSs with the proposed methods. Compared with the reported results, the proposed results obtain a much less conservative MADB which are more general. Numerical example and simulation is used to illustrate the effectiveness of the proposed methods.

  15. Classic conditioning in aged rabbits: delay, trace, and long-delay conditioning.

    Solomon, P R; Groccia-Ellison, M E


    Young (0.5 years) and aged (2+, 3+, and 4+ years) rabbits underwent acquisition of the classically conditioned nictitating membrane response in a delay (500-ms conditioned stimulus [CS], 400-ms interstimulus interval [ISI]), long-delay (1,000-ms CS, 900-ms ISI), or trace (500-ms CS, 400-ms stimulus-free period) paradigm. Collapsing across age groups, there is a general tendency for animals to acquire trace conditioning more slowly than delay conditioning. Collapsing across conditioning paradigms, there is a general tendency for aged animals to acquire more slowly than younger animals. Of greater significance, however, are the age differences in the different conditioning paradigms. In the delay and long-delay paradigms, significant conditioning deficits first appeared in the 4(+)-year-old group. In the trace conditioning paradigm, significant conditioning deficits became apparent in the 2(+)-year-old animals.

  16. Delay-dependent robust stability for neutral systems with mixed discrete-and-neutral delays

    Yong HE; Min WU; Jinhua SHE


    This paper focuses on the problem of delay-dependent robust stability of neutral systems with different discrete-and-neutral delays and time-varying structured uncertainties.Some new criteria are presented,in which some free weighting matrices are used to express the relationships between the terms in the Leibniz-Newton formula.The criteria include the information on the size of both neutral-and-discrete delays.It is shown that the present results also include the results for identical discrete-and-neutral delays as special cases.A numerical example illustrates the improvement of the proposed methods over the previous methods and the influences between the discrete and neutral delays.

  17. Relation between delayed feedback and delay-coupled systems and its application to chaotic lasers

    Soriano, Miguel C., E-mail:; Flunkert, Valentin; Fischer, Ingo [Instituto de Física Interdisciplinar y Sistemas Complejos, IFISC (CSIC-UIB), Campus Universitat Illes Balears, E-07122 Palma de Mallorca (Spain)


    We present a systematic approach to identify the similarities and differences between a chaotic system with delayed feedback and two mutually delay-coupled systems. We consider the general case in which the coupled systems are either unsynchronized or in a generally synchronized state, in contrast to the mostly studied case of identical synchronization. We construct a new time-series for each of the two coupling schemes, respectively, and present analytic evidence and numerical confirmation that these two constructed time-series are statistically equivalent. From the construction, it then follows that the distribution of time-series segments that are small compared to the overall delay in the system is independent of the value of the delay and of the coupling scheme. By focusing on numerical simulations of delay-coupled chaotic lasers, we present a practical example of our findings.

  18. Asymptotic Hyperstability of Dynamic Systems with Point Delays

    M. De la Sen


    Full Text Available It is proved that a linear time-invariant system with internal point delays is asymptotically hyperstable independent of the delays if an associate delay-free system is asymptotically hyperstable and the delayed dynamics are sufficiently small.

  19. Patient delay in patients with ST-elevation myocardial infarction

    Nielsen, Christel Ga; Laut, Kristina G; Jensen, Lisette O


    BACKGROUND AND AIMS: To improve treatment success of ST-elevation myocardial infarction, a minimal delay from symptom onset to reperfusion therapy is crucial. The patient's response to initial symptoms (patient delay) substantially affects the delay. We investigated time patterns of patient delay...

  20. Timing of autumn bird migration under climate change: advances in long-distance migrants, delays in short-distance migrants

    Jenni, L.; Kery, M.


    As a response to increasing spring temperature in temperate regions in recent years, populations of many plant and animal species, including migratory birds, have advanced the seasonal start of their reproduction or growth. However, the effects of climate changes on subsequent events of the annual cycle remain poorly understood. We investigated long-term changes in the timing of autumn migration in birds, a key event in the annual cycle limiting the reproductive period. Using data spanning a 42-year period, we analysed long-term changes in the passage of 65 species of migratory birds through Western Europe. The autumn passage of migrants wintering south of the Sahara has advanced in recent years, presumably as a result of selection pressure to cross the Sahel before its seasonal dry period. In contrast, migrants wintering north of the Sahara have delayed autumn passage. In addition, species with a variable rather than a fixed number of broods per year have delayed passage, possibly because they are free to attempt more broods. Recent climate changes seem to have a simple unidirectional effect on the seasonal onset of reproduction, but complex and opposing effects on the timing of subsequent events in the annual cycle, depending on the ecology and life history of a species. This complicates predictions of overall effects of global warming on avian communities.