Supergravity one-loop corrections on AdS7 and AdS3, higher spins and AdS/CFT

Directory of Open Access Journals (Sweden)

Matteo Beccaria

2015-03-01

Full Text Available As was shown earlier, the one-loop correction in 10d supergravity on AdS5×S5 corresponds to the contributions to the vacuum energy and 4d boundary conformal anomaly which are minus the values for one N=4 Maxwell supermultiplet, thus reproducing the subleading term in the N2−1 coefficient in the dual SU(N SYM theory. We perform similar one-loop computations in 11d supergravity on AdS7×S4 and 10d supergravity on AdS3×S3×T4. In the AdS7 case we find that the corrections to the 6d conformal anomaly a-coefficient and the vacuum energy are again minus the ones for one (2,0 tensor multiplet, suggesting that the total a-anomaly coefficient for the dual (2,0 theory is 4N3−9/4N−7/4 and thus vanishes for N=1. In the AdS3 case the one-loop correction to the vacuum energy or 2d central charge turns out to be equal to that of one free (4,4 scalar multiplet, i.e. is c=+6. This reproduces the subleading term in the central charge c=6(Q1Q5+1 of the dual 2d CFT describing decoupling limit of D5–D1 system. We also present the expressions for the 6d a-anomaly coefficient and vacuum energy contributions of general-symmetry higher spin field in AdS7 and consider their application to tests of vectorial AdS/CFT with the boundary conformal 6d theory represented by free scalars, spinors or rank-2 antisymmetric tensors.

Social Cost Benefit Analysis of HL-LHC

CERN Document Server

Bastianin, Andrea

2018-01-01

We present a Social Cost–Benefit Analysis (CBA) of the High Luminosity upgrade of the Large Hadron Collider (HL-LHC), assessing its economic costs and benefits up to 2038. The Net Present Value (NPV) of the HL-LHC project is positive at the end of the observation period. The ratio between incremental benefits and incremental costs of the HL-LHC with respect to continue operating the LHC under normal consolidation (i.e. without high-luminosity upgrade) is slightly over 1.7, meaning that each Swiss Franc invested in the HL-LHC upgrade project pays back approximately 1.7 CHF in societal benefits. Simulations based on 50000 Monte Carlo rounds show that there is a 94% chance to observe a positive NPV (i.e. a quantifiable economic benefit for the society). The attractiveness of CERN for Early Stage Researchers (ESR) is key for a positive CBA result. Given that benefits to ESRs are the single most important societal benefit, CERN should invest more in activities facilitating the transition to the international job...

Mapping HL7 CDA R2 Formatted Mass Screening Data to OpenEHR Archetypes.

Science.gov (United States)

Kobayashi, Shinji; Kume, Naoto; Yoshihara, Hiroyuki

2017-01-01

Mass screening of adults was performed to manage employee healthcare. The screening service defined the data collection format as HL7 Clinical Document Architecture (CDA) R2. To capture mass screening data for nationwide electronic health records (her), we programmed a model within the CDA format and mapped the data items to the ISO13606/openEHR archetype for semantic interoperabiilty.

A generic, web-based clinical information system architecture using HL7 CDA: successful implementation in dermatological routine care.

Science.gov (United States)

Schuler, Thilo; Boeker, Martin; Klar, Rüdiger; Müller, Marcel

2007-01-01

The requirements of highly specialized clinical domains are often underrepresented in hospital information systems (HIS). Common consequences are that documentation remains to be paper-based or external systems with insufficient HIS integration are used. This paper presents a solution to overcome this deficiency in the form of a generic framework based on the HL7 Clinical Document Architecture. The central architectural idea is the definition of customized forms using a schema-controlled XML language. These flexible form definitions drive the user interface, the data storage, and standardized data exchange. A successful proof-of-concept application in a dermatologic outpatient wound care department has been implemented, and is well accepted by the clinicians. Our work with HL7 CDA revealed the need for further practical research in the health information standards realm.

Comparison of EuroMISE Minimal Data Model for Cardiology and HL7 V3 DAM: Cardiology Rel. 2

Czech Academy of Sciences Publication Activity Database

Seidl, Libor; Hanzlíček, Petr

2011-01-01

Roč. 7, č. 1 (2011), s. 33-36 ISSN 1801-5603 R&D Projects: GA MŠk(CZ) 1M06014 Institutional research plan: CEZ:AV0Z10300504 Keywords : data model * EuroMISE MDMC * HL7 V3 DAM cardiology * comparison Subject RIV: IN - Informatics, Computer Science http://www.ejbi.eu/images/2011-1/Seidl_en.pdf

Prototype of a Standards-Based EHR and Genetic Test Reporting Tool Coupled with HL7-Compliant Infobuttons

Science.gov (United States)

Crump, Jacob K.; Del Fiol, Guilherme; Williams, Marc S.; Freimuth, Robert R.

2018-01-01

Integration of genetic information is becoming increasingly important in clinical practice. However, genetic information is often ambiguous and difficult to understand, and clinicians have reported low-self-efficacy in integrating genetics into their care routine. The Health Level Seven (HL7) Infobutton standard helps to integrate online knowledge resources within Electronic Health Records (EHRs) and is required for EHR certification in the US. We implemented a prototype of a standards-based genetic reporting application coupled with infobuttons leveraging the Infobutton and Fast Healthcare Interoperability Resources (FHIR) Standards. Infobutton capabilities were provided by Open Infobutton, an open source package compliant with the HL7 Infobutton Standard. The resulting prototype demonstrates how standards-based reporting of genetic results, coupled with curated knowledge resources, can provide dynamic access to clinical knowledge on demand at the point of care. The proposed functionality can be enabled within any EHR system that has been certified through the US Meaningful Use program.

Structure-activity relationship studies of 5,7-dihydroxyflavones as naturally occurring inhibitors of cell proliferation in human leukemia HL-60 cells.

Science.gov (United States)

Ninomiya, Masayuki; Nishida, Kyohei; Tanaka, Kaori; Watanabe, Kunitomo; Koketsu, Mamoru

2013-07-01

Flavonoids are widely occurring polyphenols that are found in plants. The aim of this study was to investigate the structure-activity relationships of 5,7-dihydroxyflavones, with a focus on the effect of B ring structure substitution on the antiproliferative effects of the compounds in human leukemia HL-60 cells. We prepared a series of 5,7-dihydroxyflavones and evaluated their ability to inhibit the proliferation of HL-60 cells by using the MTT assay. The apoptosis- and cell differentiation-inducing ability of the most potent flavones were investigated using staining and morphological analyses. This study explored the antileukemic and chemopreventive potency of 5,7-dihydroxyflavones, particularly diosmetin and chrysoeriol, which have both hydroxy and methoxy groups on the B ring.

Providing access to risk prediction tools via the HL7 XML-formatted risk web service.

Science.gov (United States)

Chipman, Jonathan; Drohan, Brian; Blackford, Amanda; Parmigiani, Giovanni; Hughes, Kevin; Bosinoff, Phil

2013-07-01

Cancer risk prediction tools provide valuable information to clinicians but remain computationally challenging. Many clinics find that CaGene or HughesRiskApps fit their needs for easy- and ready-to-use software to obtain cancer risks; however, these resources may not fit all clinics' needs. The HughesRiskApps Group and BayesMendel Lab therefore developed a web service, called "Risk Service", which may be integrated into any client software to quickly obtain standardized and up-to-date risk predictions for BayesMendel tools (BRCAPRO, MMRpro, PancPRO, and MelaPRO), the Tyrer-Cuzick IBIS Breast Cancer Risk Evaluation Tool, and the Colorectal Cancer Risk Assessment Tool. Software clients that can convert their local structured data into the HL7 XML-formatted family and clinical patient history (Pedigree model) may integrate with the Risk Service. The Risk Service uses Apache Tomcat and Apache Axis2 technologies to provide an all Java web service. The software client sends HL7 XML information containing anonymized family and clinical history to a Dana-Farber Cancer Institute (DFCI) server, where it is parsed, interpreted, and processed by multiple risk tools. The Risk Service then formats the results into an HL7 style message and returns the risk predictions to the originating software client. Upon consent, users may allow DFCI to maintain the data for future research. The Risk Service implementation is exemplified through HughesRiskApps. The Risk Service broadens the availability of valuable, up-to-date cancer risk tools and allows clinics and researchers to integrate risk prediction tools into their own software interface designed for their needs. Each software package can collect risk data using its own interface, and display the results using its own interface, while using a central, up-to-date risk calculator. This allows users to choose from multiple interfaces while always getting the latest risk calculations. Consenting users contribute their data for future

Preliminary study of energy confinement data with a statistical analysis system in HL-2A tokamak

International Nuclear Information System (INIS)

Xu Yuan; Cui Zhengying; Ji Xiaoquan; Dong Chunfeng; Yang Qingwei; O J W F Kardaun

2010-01-01

Taking advantage of the HL-2A experimental data,an energy confinement database facing ITERL DB2.0 version has been originally established. As for this database,a world widely used statistical analysis system (SAS) has been adopted for the first time to analyze and evaluate the confinement data from HL-2A and the research on scaling laws of energy confinement time corresponding to plasma density is developed, some preliminary results having been achieved. Finally, through comparing with both ITER scaling law and previous ASDEX database, the investigation about L-mode confinement quality on HL-2A and influence of temperature on Spitzer resistivity will be discussed. (authors)

McStas 1.7 - a new version of the flexible Monte Carlo neutron scattering package

DEFF Research Database (Denmark)

Willendrup, P.; Farhi, E.; Lefmann, K.

2004-01-01

in collaboration between Riso and ILL. The new version (1.7) has many improvements, among these added support for the popular Microsoft Windows platform. This presentation will demonstrate a selection of the new features through a simulation of the ILL IN6 beamline. (C) 2004 Elsevier B.V. All rights reserved....

Virtual file system on NoSQL for processing high volumes of HL7 messages.

Science.gov (United States)

Kimura, Eizen; Ishihara, Ken

2015-01-01

The Standardized Structured Medical Information Exchange (SS-MIX) is intended to be the standard repository for HL7 messages that depend on a local file system. However, its scalability is limited. We implemented a virtual file system using NoSQL to incorporate modern computing technology into SS-MIX and allow the system to integrate local patient IDs from different healthcare systems into a universal system. We discuss its implementation using the database MongoDB and describe its performance in a case study.

Integrable systems from membranes on AdS4 x S7

International Nuclear Information System (INIS)

Bozhilov, P.

2008-01-01

We describe how Neumann and Neumann-Rosochatius type integrable systems, as well as the continuous limit of the SU(2) integrable spin chain, can be obtained from membranes on AdS 4 x S 7 background, in the framework of AdS/CFT correspondence. (Abstract Copyright [2008], Wiley Periodicals, Inc.)

Unitary Supermultiplets of $OSp(8^{*}|4)$ and the $AdS_{7}/CFT_{6}$ Duality

CERN Document Server

Günaydin, M; Gunaydin, Murat; Takemae, Seiji

2000-01-01

We study the unitary supermultiplets of the N=4 d=7 anti-de Sitter (AdS_7) superalgebra OSp(8^*|4), with the even subalgebra SO(6,2) X USp(4), which is the symmetry superalgebra of M-theory on AdS_7 X S^4. We give a complete classification of the positive energy doubleton and massless supermultiplets of OSp(8^*|4) . The ultra-short doubleton supermultiplets do not have a Poincaré limit in AdS_7 and correspond to superconformal field theories on the boundary of AdS_7 which can be identified with d=6 Minkowski space. We show that the six dimensional Poincare mass operator vanishes identically for the doubleton representations. By going from the compact U(4) basis of SO^*(8)=SO(6,2) to the noncompact basis SU^*(4)XD (d=6 Lorentz group times dilatations) one can associate the positive (conformal) energy representations of SO^*(8) with conformal fields transforming covariantly under the Lorentz group in d=6. The oscillator method used for the construction of the unitary supermultiplets of OSp(8^*|4) can be given ...

Comparison and Analysis of ISO/IEEE 11073, IHE PCD-01, and HL7 FHIR Messages for Personal Health Devices.

Science.gov (United States)

Lee, Sungkee; Do, Hyoungho

2018-01-01

Increasing use of medical devices outside of healthcare facilities inevitably requires connectivity and interoperability between medical devices and healthcare information systems. To this end, standards have been developed and used to provide interoperability between personal health devices (PHDs) and external systems. ISO/IEEE 11073 standards and IHE PCD-01 standard messages have been used the most in the exchange of observation data of health devices. Recently, transmitting observation data using the HL7 FHIR standard has been devised in the name of DoF (Devices on FHIR) and adopted very fast. We compare and analyze these standards and suggest that which standard will work best at the different environments of device usage. We generated each message/resource of the three standards for observed vital signs from blood pressure monitor and thermometer. Then, the size, the contents, and the exchange processes of these messages are compared and analyzed. ISO/IEEE 11073 standard message has the smallest data size, but it has no ability to contain the key information, patient information. On the other hand, PCD-01 messages and FHIR standards have the fields for patient information. HL7 DoF standards provide reusing of information unit known as resource, and it is relatively easy to parse DoF messages since it uses widely known XML and JSON. ISO/IEEE 11073 standards are suitable for devices having very small computing power. IHE PCD-01 and HL7 DoF messages can be used for the devices that need to be connected to hospital information systems that require patient information. When information reuse is frequent, DoF is advantageous over PCD-01.

Primary structure of segment 7 of the RNA of the influenza virus A/USSR/90/77 (HlNl)

International Nuclear Information System (INIS)

Samokhvalov, E.I.; Karginov, V.A.; Chizhikov, V.E.; Blinov, V.M.; Yuferov, V.P.; Vasilenko, S.K.; Uryvaev, L.V.; Zhdanov, V.M.

1986-01-01

The nucleotide sequence of segment 7 of the RNA of the influenza virus A/USSR/90/77 (HlNl) has been determined, and an analysis has been given of the nucleotide substitutions in comparison with known primary structures of segment 7 of other strains of the influenza virus. A hypothetical model of the secondary structure of segment 7 of the RNA of the influenza virus and a direct repeat both at the nucleotide level and at the amino acid level found in the center of the M 1 protein are discussed

Selections from 2016: Gaps in HL Tau's Protoplanetary Disk

Science.gov (United States)

Kohler, Susanna

2016-12-01

Editors note:In these last two weeks of 2016, well be looking at a few selections that we havent yet discussed on AAS Nova from among the most-downloaded paperspublished in AAS journals this year. The usual posting schedule will resume after the AAS winter meeting.Gas Gaps in the Protoplanetary Disk Around the Young Protostar HL TauPublished March 2016The dust (left) and gas (right) emission from HL Tau show that the gaps in its disk match up. [Yen et al. 2016]Main takeaway:At the end of last year, the Atacama Large Millimeter/Submillimeter Array released some of its first data including a spectacular observation of a dusty protoplanetary disk around the young star HL Tau. In this follow-up study, a team led by Hsi-Wei Yen (Academia Sinica Institute of Astronomy and Astrophysics, Taiwan) analyzed the ALMA data and confirmed the presence of two gaps in the gas of HL Taus disk, at radii of 28 and 69 AU.Why its interesting:The original ALMA image of HL Taus disk suggests the presence of gaps in disk, but scientists werent sure if they were caused by effects like gravitational instabilities or dust clumping, or if the gaps were created by the presence of young planets. Yen and collaborators showed that gaps in the disks gas line up with gaps in its dust, supporting the model in which these gaps have been carved out by newly formed planets.Added intrigue:The evidence for planets in this disk came as a bit of a surprise, since it was originally believed that it takes tens of millions of years to form planets from the dust of protoplanetary disks but HL Tau is only a million years old. These observations therefore suggest that planets start to form much earlier than we thought.CitationHsi-Wei Yen et al 2016 ApJL 820 L25. doi:10.3847/2041-8205/820/2/L25

Hans Pöhl - Estlandssvenskarnas hövding = Hans Pöhl - rannarootslaste eestvõitleja / Torkel Jansson

Index Scriptorium Estoniae

Jansson, Torkel, 1947-

2011-01-01

Raamatututvustus: Hans Pöhl - Estlandssvenskarnas hövding : en biografi över Hans Pöhl (1876-1930), estlandssvenskarnas främste företrädare och ledare = Hans Pöhl - rannarootslaste eestvõitleja : Hans Pöhli (1876-1930), Eesti rootslaste vaimse liidri ja valgustaja elulugu. (Stockholm ; Tallinn, 2010)

Automated realtime data import for the i2b2 clinical data warehouse: introducing the HL7 ETL cell.

Science.gov (United States)

Majeed, Raphael W; Röhrig, Rainer

2012-01-01

Clinical data warehouses are used to consolidate all available clinical data from one or multiple organizations. They represent an important source for clinical research, quality management and controlling. Since its introduction, the data warehouse i2b2 gathered a large user base in the research community. Yet, little work has been done on the process of importing clinical data into data warehouses using existing standards. In this article, we present a novel approach of utilizing the clinical integration server as data source, commonly available in most hospitals. As information is transmitted through the integration server, the standardized HL7 message is immediately parsed and inserted into the data warehouse. Evaluation of import speeds suggest feasibility of the provided solution for real-time processing of HL7 messages. By using the presented approach of standardized data import, i2b2 can be used as a plug and play data warehouse, without the hurdle of customized import for every clinical information system or electronic medical record. The provided solution is available for download at http://sourceforge.net/projects/histream/.

Von Hippel-Lindau disease (vHL)

DEFF Research Database (Denmark)

Binderup, Marie Louise Mølgaard; Bisgaard, Søs Marie Luise; Harbud, Vibeke

2013-01-01

These clinical guidelines outline the criteria and recommendations for diagnostic and genetic work-up of families suspected of von Hippel-Lindau disease (vHL), as well as recommendations for prophylactic surveillance for vHL patients. The guideline has been composed by the Danish Coordination Group...... for vHL which is comprised of Danish doctors and specialists interested in vHL. The recommendations are based on longstanding clinical experience, Danish original research, and extensive review of the international literature. vHL is a hereditary multi-tumour disease caused by germline mutations...... of the disease, and/or in individuals with a vHL-associated manifestation; i.e. a hemangioblastoma in the retina or the central nervous system, familial or bilateral pheochromocytomas, familial, multiple, or early onset renal cell carcinomas, and in individuals with an endolymphatic sac tumour in the inner ear...

A future-proof architecture for telemedicine using loose-coupled modules and HL7 FHIR.

Science.gov (United States)

Gøeg, Kirstine Rosenbeck; Rasmussen, Rune Kongsgaard; Jensen, Lasse; Wollesen, Christian Møller; Larsen, Søren; Pape-Haugaard, Louise Bilenberg

2018-07-01

Most telemedicine solutions are proprietary and disease specific which cause a heterogeneous and silo-oriented system landscape with limited interoperability. Solving the interoperability problem would require a strong focus on data integration and standardization in telemedicine infrastructures. Our objective was to suggest a future-proof architecture, that consisted of small loose-coupled modules to allow flexible integration with new and existing services, and the use of international standards to allow high re-usability of modules, and interoperability in the health IT landscape. We identified core features of our future-proof architecture as the following (1) To provide extended functionality the system should be designed as a core with modules. Database handling and implementation of security protocols are modules, to improve flexibility compared to other frameworks. (2) To ensure loosely coupled modules the system should implement an inversion of control mechanism. (3) A focus on ease of implementation requires the system should use HL7 FHIR (Fast Interoperable Health Resources) as the primary standard because it is based on web-technologies. We evaluated the feasibility of our architecture by developing an open source implementation of the system called ORDS. ORDS is written in TypeScript, and makes use of the Express Framework and HL7 FHIR DSTU2. The code is distributed on GitHub. All modules have been tested unit wise, but end-to-end testing awaits our first clinical example implementations. Our study showed that highly adaptable and yet interoperable core frameworks for telemedicine can be designed and implemented. Future work includes implementation of a clinical use case and evaluation. Copyright © 2018 Elsevier B.V. All rights reserved.

Physics Prospects at the HL-LHC with ATLAS

CERN Document Server

Duncan, Anna Kathryn; The ATLAS collaboration

2017-01-01

The High-Luminosity LHC aims to provide a total integrated luminosity of 3000 fb-1 from p-p collisions at $\\sqrt{s}$ = 14 TeV over the course of $\\sim$ 10 years, reaching instantaneous luminosities of up to L = 7.5 $\\times$ 1034cm$^{-2}$s$^{-1}$, corresponding to an average ($\\mu$) of 200 inelastic p-p collisions per bunch crossing. The upgraded ATLAS detector must be able to cope well with increased occupancies and data rates. The performance of the upgrade has been estimated in full simulation studies, assuming expected HL-LHC conditions and a detector configuration intended to maximise physics performance and discovery potential at the HL-LHC. The performance is expected to be similar to what we have now. Simulation studies have been carried out to evaluate the prospects of various benchmark physics analyses to be performed using the upgraded ATLAS detector with the full HL-LHC dataset.

Pilot Peter Hoag and HL-10

Science.gov (United States)

1969-01-01

Air Force Major Peter Hoag stands in front of the HL-10 Lifting Body. Maj. Hoag joined the HL-10 program in 1969 and made his first glide flight on June 6, 1969. He made a total of 8 flights in the HL-10. They included the fastest lifting-body flight, which reached Mach 1.861 on Feb. 18, 1970. The HL-10 was one of five heavyweight lifting-body designs flown at NASA's Flight Research Center (FRC--later Dryden Flight Research Center), Edwards, California, from July 1966 to November 1975 to study and validate the concept of safely maneuvering and landing a low lift-over-drag vehicle designed for reentry from space. Northrop Corporation built the HL-10 and M2-F2, the first two of the fleet of 'heavy' lifting bodies flown by the NASA Flight Research Center. The contract for construction of the HL-10 and the M2-F2 was $1.8 million. 'HL' stands for horizontal landing, and '10' refers to the tenth design studied by engineers at NASA's Langley Research Center, Hampton, Va. After delivery to NASA in January 1966, the HL-10 made its first flight on Dec. 22, 1966, with research pilot Bruce Peterson in the cockpit. Although an XLR-11 rocket engine was installed in the vehicle, the first 11 drop flights from the B-52 launch aircraft were powerless glide flights to assess handling qualities, stability, and control. In the end, the HL-10 was judged to be the best handling of the three original heavy-weight lifting bodies (M2-F2/F3, HL-10, X-24A). The HL-10 was flown 37 times during the lifting body research program and logged the highest altitude and fastest speed in the Lifting Body program. On Feb. 18, 1970, Air Force test pilot Peter Hoag piloted the HL-10 to Mach 1.86 (1,228 mph). Nine days later, NASA pilot Bill Dana flew the vehicle to 90,030 feet, which became the highest altitude reached in the program. Some new and different lessons were learned through the successful flight testing of the HL-10. These lessons, when combined with information from it's sister ship, the M2

The CMS Outer Tracker for HL-LHC

CERN Document Server

Dierlamm, Alexander Hermann

2018-01-01

The LHC is planning an upgrade program, which will bring the luminosity to about $5-7\\times10^{34}$~cm$^{-2}$s$^{-1}$ in 2026, with a goal of an integrated luminosity of 3000 fb$^{-1}$ by the end of 2037. This High Luminosity LHC scenario, HL-LHC, will require a preparation program of the LHC detectors known as Phase-2 Upgrade. The current CMS Tracker is already running beyond design specifications and will not be able to cope with the HL-LHC radiation conditions. CMS will need a completely new Tracker in order to fully exploit the highly demanding operating conditions and the delivered luminosity. The new Outer Tracker system is designed to provide robust tracking as well as Level-1 trigger capabilities using closely spaced modules composed of silicon macro-pixel and/or strip sensors. Research and development activities are ongoing to explore options and develop module components and designs for the HL-LHC environment. The design choices for the CMS Outer Tracker Upgrade are discussed along with some highlig...

Physics prospects at the HL-LHC with ATLAS

CERN Document Server

Duncan, Anna Kathryn

2017-01-01

The High-Luminosity LHC aims to provide a total integrated luminosity of 3000 fb$^{-1}$ from proton-proton collisions at $\\sqrt{s}$ = 14 TeV over the course of $\\sim$ 10 years, reaching instantaneous luminosities of up to $L = 7.5 \\times 10^{34} cm^{-2} s^{-1}$, corresponding to an average of 200 inelastic p-p collisions per bunch crossing ($\\mu = 200)$. The upgraded ATLAS detector and trigger system must be able to cope well with increased occupancies and data rates. The performance of the upgrade has been estimated in full simulation studies, assuming expected HL-LHC conditions and a detector configuration intended to maximise physics performance and discovery potential at the HL-LHC, and is expected to be similar to current performance. Fast simulation studies have been carried out to evaluate the prospects of various benchmark physics analyses to be performed using the upgraded ATLAS detector with the full HL-LHC dataset.

Expected performance of tracking and vertexing with the HL-LHC ATLAS detector

CERN Document Server

Calace, Noemi; The ATLAS collaboration

2018-01-01

The High Luminosity LHC (HL-LHC) aims to increase the LHC data-set by an order of magnitude in order to increase its potential for discoveries. Starting from the middle of 2026, the HL-LHC is expected to reach the peak instantaneous luminosity of $7.5 \\cdot 10^{34} cm^{-2}s^{-1}$ which corresponds to about 200 inelastic proton-proton collisions per beam crossing. To cope with the large radiation doses and high pileup, the current ATLAS Inner Detector will be replaced with a new all-silicon Inner Tracker. In this talk the expected performance of tracking and vertexing with the HL-LHC tracker is presented. Comparison is made to the performance with the Run2 detector. Ongoing developments of the track reconstruction for the HL-LHC are also discussed.

Design and development of a tele-healthcare information system based on web services and HL7 standards.

Science.gov (United States)

Huang, Ean-Wen; Hung, Rui-Suan; Chiou, Shwu-Fen; Liu, Fei-Ying; Liou, Der-Ming

2011-01-01

Information and communication technologies progress rapidly and many novel applications have been developed in many domains of human life. In recent years, the demand for healthcare services has been growing because of the increase in the elderly population. Consequently, a number of healthcare institutions have focused on creating technologies to reduce extraneous work and improve the quality of service. In this study, an information platform for tele- healthcare services was implemented. The architecture of the platform included a web-based application server and client system. The client system was able to retrieve the blood pressure and glucose levels of a patient stored in measurement instruments through Bluetooth wireless transmission. The web application server assisted the staffs and clients in analyzing the health conditions of patients. In addition, the server provided face-to-face communications and instructions through remote video devices. The platform deployed a service-oriented architecture, which consisted of HL7 standard messages and web service components. The platform could transfer health records into HL7 standard clinical document architecture for data exchange with other organizations. The prototyping system was pretested and evaluated in a homecare department of hospital and a community management center for chronic disease monitoring. Based on the results of this study, this system is expected to improve the quality of healthcare services.

Overview of HL-2A experiment results

International Nuclear Information System (INIS)

Yang, Q.W.; Yong Liu; Ding, X.T.

2007-01-01

Recent experiment results from the HL-2A tokamak are presented in this paper. Supersonic molecular beam injection (SMBI) with liquid nitrogen temperature propellant is used. Low temperature SMBI can form hydrogen clusters that penetrate into the plasma more deeply and efficiently. Particle diffusion coefficient and convection velocity (D = 0.5-1.5 m 2 s -1 and V conv -1 , respectively) are obtained at the plasma periphery using modulated SMBI. Multi-probe measurements reveal the m = 0-1, n = 0 symmetries of directly measured low frequency (7-9 kHz) electric potential and field are simultaneously observed for the first time. Impurity transport is determined with the laser blow-off system and transport code. A disruption predictor has been derived based on MHD activity observations and statistical analysis. Sawtooth characteristics during ECRH are investigated and coupling between m = 1 and m/n = 2/1 modes is studied. Detachment features of HL-2A divertor are numerically and experimentally studied using the code SOLPS5.0 and measured data. The long divertor legs and thin divertor throats in HL-2A pose MHD shaping problems resulting in momentum losses even at low densities and strongly enhanced main chamber losses

Probiotic assessment of Enterococcus durans 6HL and Lactococcus lactis 2HL isolated from vaginal microflora.

Science.gov (United States)

Nami, Yousef; Abdullah, Norhafizah; Haghshenas, Babak; Radiah, Dayang; Rosli, Rozita; Khosroushahi, Ahmad Yari

2014-08-01

Forty-five lactic acid bacteria (LAB) were isolated from the vaginal specimens of healthy fertile women, and the identities of the bacteria were confirmed by sequencing of their 16S rDNA genes. Among these bacteria, only four isolates were able to resist and survive in low pH, bile salts and simulated in vitro digestion conditions. Lactococcus lactis 2HL, Enterococcus durans 6HL, Lactobacillus acidophilus 36YL and Lactobacillus plantarum 5BL showed the best resistance to these conditions. These strains were evaluated further to assess their ability to adhere to human intestinal Caco-2 cells. Lactococcus lactis 2HL and E. durans 6HL were the most adherent strains. In vitro tests under neutralized pH proved the antimicrobial activity of both strains. Results revealed that the growth of Escherichia coli O26, Staphylococcus aureus and Shigella flexneri was suppressed by both LAB strains. The antibiotic susceptibility tests showed that these strains were sensitive to all nine antibiotics: vancomycin, tetracycline, ampicillin, penicillin, gentamicin, erythromycin, clindamycin, sulfamethoxazole and chloramphenicol. These data suggest that E. durans 6HL and Lactococcus lactis 2HL could be examined further for their useful properties and could be developed as new probiotics. © 2014 The Authors.

HL-LHC parameter space and scenarios

International Nuclear Information System (INIS)

Bruning, O.S.

2012-01-01

The HL-LHC project aims at a total integrated luminosity of approximately 3000 fb -1 over the lifetime of the HL-LHC. Assuming an exploitation period of ca. 10 years this goal implies an annual integrated luminosity of approximately 200 fb -1 to 300 fb -1 per year. This paper looks at potential beam parameters that are compatible with the HL-LHC performance goals and discusses briefly potential variation in the parameter space. It is shown that the design goal of the HL-LHC project can only be achieved with a full upgrade of the injector complex and the operation with β* values close to 0.15 m. Significant margins for leveling can be achieved for β* values close to 0.15 m. However, these margins can only be harvested during the HL-LHC operation if the required leveling techniques have been demonstrated in operation

Rannarootslaste suurmees Hans Pöhl / Olev Liivik

Index Scriptorium Estoniae

Liivik, Olev, 1975-

2011-01-01

Arvustus: Estlandssvenskarnas hövding. En biografi över Hans Pöhl (1876-1930), estlandssvenskarnas främste företrädare och ledare = Hans Pöhl - rannarootslaste eestvõileja : Hans Pöhl (1876-1930), Eesti rootslaste vaimse liidri ja valgustaja elulugu. Stockholm, 2010

GREEN MARKETING AND REPRESENTATION OF THE OTHER (An Analysis of Green Image Ad Represented by Teh Kotak Ad, ‘Persembahan dari Alam’ Version

Directory of Open Access Journals (Sweden)

Tangguh Okta Wibowo

2017-12-01

Full Text Available This paper presents a theoretical link among green marketing of Teh Kotak ad, “Persembahan dari Alam” version. This is an ad telling as if the product of Teh Kotak is truly from nature. In addition, this research explored the portrayal of how this ad contains metaphorical element to juxtapose nature and technology as the same level. In the analysis, this study attempts to use Green marketing theory as a tool for analysis to explore what is the message behind the ad. Moreover, exploring the representation of the portion of the position of gender where the ad uses a woman as the main actor picking tea leaf, as if this ad looks natural. The result of the study revealed that Green marketing showed it competences to cover with political agenda. It is reflected in green image which told that The Kotak is a gift from nature. Overall, this study concludes that green image of this ad relays the hidden meaning, where the main aim is inviting people to buy its product as political agendas. Keywords: Green marketing; gift; Nature; Teh Kotak

Effect of citrus flavonoids on HL-60 cell differentiation.

Science.gov (United States)

Kawaii, S; Tomono, Y; Katase, E; Ogawa, K; Yano, M

1999-01-01

Twenty-seven Citrus flavonoids were examined for their activity of induction of terminal differentiation of human promyelocytic leukemia cells (HL-60) by nitro blue tetrazolium (NBT) reducing, nonspecific esterase, specific esterase, and phagocytic activities. 10 flavonoids were judged to be active (percentage of NBT reducing cells was more than 40% at a concentration of 40 microM), and the rank order of potency was natsudaidain, luteolin, tangeretin, quercetin, apigenin, 3, 3, '4, '5, 6, 7, 8-heptamethoxyflavone, nobiletin, acacetin, eriodictyol, and taxifolin. These flavonoids exerted their activity in a dose-dependent manner. HL-60 cells treated with these flavonoids differentiated into mature monocyte/macrophage. The structure-activity relationship established from comparison between flavones and flavanones revealed that ortho-catechol moiety in ring B and C2-C3 double bond had an important role for induction of differentiation of HL-60. In polymethoxylated flavones, hydroxyl group at C3 and methoxyl group at C8 enhanced the differentiation-inducing activity.

Modification of steel 35 HL surge current during crystallization

Directory of Open Access Journals (Sweden)

Zhbanova O.M.

2017-04-01

Full Text Available The method of electro steel melt modification 35 HL variable polarity current pulses with a duration of more 10-3s frequency within the 5–33 Hz, 5–24 porosity meanders, strength 30–40 A at a voltage of 180–240 V during crystallization, which allows to obtain high-quality castings 35 HL steel grade. Show that electro melt processing improves the structure and reduces the physical heterogeneity of castings and increases the rate of dissolution of metallic impurities and other components in the melt, providing fine-grained structure and increases the homogeneity of metal carbides reduces the amount of manganese reduces gases and nonmetallic inclusions. Modifying steel 35 HL pulse current during crystallization of the melt increases the physical and mechanical properties of tempered steel, increasing yield strength by 30 %, the tensile strength at 7 % elongation of 1,5 % relative narrowing by 2 %, toughness at 20 %.

Introduction to the HL-LHC Project

CERN Document Server

Rossi , L

2015-01-01

The Large Hadron Collider (LHC) is one of largest scientific instruments ever built. It has been exploring the new energy frontier since 2010, gathering a global user community of 7,000 scientists. To extend its discovery potential, the LHC will need a major upgrade in the 2020s to increase its luminosity (rate of collisions) by a factor of five beyond its design value and the integrated luminosity by a factor of ten. As a highly complex and optimized machine, such an upgrade of the LHC must be carefully studied and requires about ten years to implement. The novel machine configuration, called High Luminosity LHC (HL-LHC), will rely on a number of key innovative technologies, representing exceptional technological challenges, such as cutting-edge 11–12 tesla superconducting magnets, very compact superconducting cavities for beam rotation with ultra-precise phase control, new technology for beam collimation and 300-meter-long high-power superconducting links with negligible energy dissipation. HL-LHC federa...

Von Hippel-Lindau disease (vHL)

DEFF Research Database (Denmark)

Binderup, Marie Louise Mølgaard; Bisgaard, Søs Marie Luise; Harbud, Vibeke

2013-01-01

for vHL which is comprised of Danish doctors and specialists interested in vHL. The recommendations are based on longstanding clinical experience, Danish original research, and extensive review of the international literature. vHL is a hereditary multi-tumour disease caused by germline mutations....../MRI of the abdomen, e) annual plasma-metanephrine, plasma-normetanephrine, and plasma-chromogranin A tests, and f) annual hearing examination at a department of audiology. It is advised that one doctor takes on the responsibility of coordination of and referral to the many examinations, and the communication...

Commissioning and preliminary operation of HL-2A tokamak

International Nuclear Information System (INIS)

Liu Dequan; Liu Yong; Yan Jianchen; Cao Zeng; Yang Qingwei; Zhou Caipin; Li Xiaodong

2005-01-01

HL-2A is a divertor tokamak located at new site of Southwestern Institute of Physics (SWIP), Chengdu, China. It can be operated in double-null and single-null divertor with closed configurations. The effects of the divertor on impurity behaviors, MHD instabilities, transport, wall conditioning and divertor physics are key issues to be studied during the first step operation on HL-2A. Preliminary experiments with limiter and single null divertor configurations were carried out in 2003. Main parameters achieved are the plasma current 168 KA, duration time of 920 ms and plasma linear-averaged density of 1.7 x 10 19 m -3 . The impurities, especially of low Z, are clearly decreased during the divertor experiments

Synthesis and Structures of Two Lanthanide Complexes Containing a Mixed Ligand System: [Ln(Phen)2(L)3(HL)]·H2O [Ln = La, Ce; Phen = Phenanthroline; HL = Salicylic Acid

International Nuclear Information System (INIS)

Iravani, Effat; Nami, Navabeh; Nabizadeh, Fatemeh; Bayani, Elham; Neumueller, Bernhard

2013-01-01

The reaction of LnCl 3 ·7H 2 O [Ln = La (1), Ce (2)] with salicylic acid (HL) and 1,10-phenanthroline (Phen) at 20 .deg. C in H 2 O/ethanol gave after work-up and recrystallization two novel lanthanide complexes with general formula [Ln(Phen) 2 (L) 3 (HL)]·H 2 O. Compounds 1 and 2 were characterized by IR and UV-Vis spectroscopy, TGA, CHN as well as by X-ray analysis. According to these results, compounds 1 and 2 are isostructural and contain Ln 3+ ions with coordination number nine. Complexes 1 and 2 consist of two Phen, one neutral HL and three L anions (two L anions act as monodentate ligands and the third one is chelating to Ln 3+ ). Thermal decomposition led to primary loss of the Phen molecules. Then HL molecules and finally L moieties left the material to give Ln 2 O 3

Expression of caspase-3 gene in apoptotic HL-60 cell and different human tumor cell lines

International Nuclear Information System (INIS)

Li Xiaoming; Song Tianbao

1999-01-01

Objective: To research the expression of caspase-3 gene in the apoptotic and the control HL-60 cells and in the different human tumor cell lines. Methods: Caspase-3 mRNA in the control and γ-radiation-induced apoptotic HL-60 cells, and in the 6 types of human tumor cell lines, was analysed by Northern blot. Results: The caspase-3 gene transcript was more highly expressed in leukemia cells HL-60, CEM, K562 and neuroblastoma SH-SY5Y than in cervical adenocarcinoma HeLa and breast carcinoma MCF7, and more highly in the radiation-induced apoptotic HL-60 than in the control HL-60 cells. Conclusion: The high level of expression of caspase-3 may aid the efforts to understand the tumor cell sensitivity to radiation, apoptosis and its inherent ability to survive

Ultraviolet B irradiation of human leukaemia HL-60 cells in vitro induces apoptosis

International Nuclear Information System (INIS)

Martin, S.J.; Cotter, T.G.

1991-01-01

UV radiation is known to be a potent agent for the induction of programmed cell death (apoptosis) in human skin. However, the mechanistic aspects of UV-induced apoptosis remain ill-defined. In this study the effects of varying periods of UV-irradiation on the human leukaemia HL-60 cell line and on five other human cell lines were investigated.HL-60 cells were found to rapidly undergo apoptosis en masse after short periods of UV-irradiation whereas prolonged exposure of these cells to this form of radiation induced a more rapid form of cell death which was suggestive of necrosis, the pathological mode of cell death. UV-induced apoptosis in cell lines was characterized by morphological changes as well as DNA fragmentation into unit multiples of ∼ 200 bp, which was indicative of endogenous endonuclease activation. This DNA fragmentation pattern was not detected in cells immediately after UV-irradiation, and was therefore not the result of direct UV-induced DNA damage. UV-induced apoptosis of the HL-60 cell line was found to require extracellular calcium and to be inhibited in a dose-dependent way by zinc added to the culture medium. (author)

Crossing scheme and orbit correction in IR1/5 for HL-LHC

CERN Document Server

Fitterer, M; Giovannozzi, M; De Maria, R

2015-01-01

In this paper we review the orbit correction strategy and crossing scheme adjustment for the HL-LHC orbit correctors in IR1/5 in view of the new optics and layout version HLLHCV1.1. To this aim the results of the studies conducted for the previous layout HLLHCV1.0 are also presented here. The main objectives are to optimize the crossing scheme, in particular to reduce the strength of the orbit correctors at D2, and to obtain an estimate for the required strength to compensate orbit distortions due to various sources.

Apoptotic and antiproliferative properties of 3β-hydroxy-Δ5-steroidal congeners from a partially purified column fraction of Dendronephthya gigantea against HL-60 and MCF-7 cancer cells.

Science.gov (United States)

Fernando, I P Shanura; Sanjeewa, K K Asanka; Kim, Hyun-Soo; Wang, Lei; Lee, Won Woo; Jeon, You-Jin

2018-04-01

Organisms belonging to the genus Dendronephthya are among a group of marine invertebrates that produce a variety of terpenoids with biofunctional properties. Many of these terpenoids have been proven effective as anticancer drugs. Here, we report the antiproliferative effect of 3β-hydroxy-Δ5-steroidal congeners against the proliferation of HL-60 human leukemia cells and MCF-7 human breast cancer cells. The sterol-rich fraction (DGEHF2-1) inhibited the growth of HL-60 and MCF-7 cells with IC 50 values of 13.59 ± 1.40 and 29.41 ± 0.87 μg ml -1 respectively. Treatment with DGEHF2-1 caused a dose-dependent increase in apoptotic body formation, DNA damage and the sub-G 1 apoptotic cell population. Moreover, DGEHF2-1 downregulated the expression of Bcl-xL while upregulating Bax, caspase-9, and PARP cleavage in both HL-60 and MCF-7 cells. The steroid fraction was found to act via the mitochondria-mediated apoptosis pathway. Identification of the sterols was performed via gas chromatography-tandem mass spectrometry analysis. Studying the mechanism of the anticancer effect caused by these sterol derivatives could lead to the identification of other natural products with anticancer properties. Copyright © 2017 John Wiley & Sons, Ltd.

Progress Towards AIRS Science Team Version-7 at SRT

Science.gov (United States)

Susskind, Joel; Blaisdell, John; Iredell, Lena; Kouvaris, Louis

2016-01-01

The AIRS Science Team Version-6 retrieval algorithm is currently producing level-3 Climate Data Records (CDRs) from AIRS that have been proven useful to scientists in understanding climate processes. CDRs are gridded level-3 products which include all cases passing AIRS Climate QC. SRT has made significant further improvements to AIRS Version-6. At the last Science Team Meeting, we described results using SRT AIRS Version-6.22. SRT Version-6.22 is now an official build at JPL called 6.2.4. Version-6.22 results are significantly improved compared to Version-6, especially with regard to water vapor and ozone profiles. We have adapted AIRS Version-6.22 to run with CrIS/ATMS, at the Sounder SIPS which processed CrIS/ATMS data for August 2014. JPL AIRS Version-6.22 uses the Version-6 AIRS tuning coefficients. AIRS Version-6.22 has at least two limitations which must be improved before finalization of Version-7: Version-6.22 total O3 has spurious high values in the presence of Saharan dust over the ocean; and Version-6.22 retrieved upper stratospheric temperatures are very poor in polar winter. SRT Version-6.28 addresses the first concern. John Blaisdell ran the analog of AIRS Version-6.28 in his own sandbox at JPL for the 14th and 15th of every month in 2014 and all of July and October for 2014. AIRS Version-6.28a is hot off the presses and addresses the second concern.

SAGE Version 7.0 Algorithm: Application to SAGE II

Science.gov (United States)

Damadeo, R. P; Zawodny, J. M.; Thomason, L. W.; Iyer, N.

2013-01-01

This paper details the Stratospheric Aerosol and Gas Experiments (SAGE) version 7.0 algorithm and how it is applied to SAGE II. Changes made between the previous (v6.2) and current (v7.0) versions are described and their impacts on the data products explained for both coincident event comparisons and time-series analysis. Users of the data will notice a general improvement in all of the SAGE II data products, which are now in better agreement with more modern data sets (e.g. SAGE III) and more robust for use with trend studies.

The Hellenic National Tsunami Warning Centre (HL-NTWC): Recent updates and future developments

Science.gov (United States)

Melis, Nikolaos S.; Charalampakis, Marinos

2014-05-01

The Hellenic NTWC (HL-NTWC) was established officially by Greek Law in September 2010. HL-NTWC is hosted at the National Observatory of Athens, Institute of Geodynamics (NOA-IG), which also operates a 24/7 earthquake monitoring service in Greece and coordinates the newly established Hellenic Unified National Seismic Network. NOA-IG and HL-NTWC Operational Centre is linked to the Civil Protection Operational Centre and serves as the official alerting agency to the General Secretariat for Civil Protection in Greece, regarding earthquake events and tsunami watch. Since August 2012, HL-NTWC acts as Candidate Tsunami Watch Provider (CTWP) under the UNESCO IOC - ICG NEAMTWS tsunami warning system (NEAM: North-Eastern Atlantic, the Mediterranean and connected seas) and offers its services to the NEAMTWS system. HL-NTWC has participated in all Communication Test Exercises (CTE) under NEAMTWS and also it has provided tsunami scenarios for extended system testing exercises such as NEAMWAVE12. Some of the recent developments at HL-NTWC in Greece include: deployment of new tide gauge stations for tsunami watch purposes, computation of tsunami scenarios and extending the database in use, improving alerting response times, earthquake magnitude estimation and testing newly established software modules for tsunami and earthquake alerting (i.e. Early-Est, SeisComP3 etc.) in Greece and the Eastern Mediterranean. Although funding today is limited, an advantage of the participation in important EC funded research projects, i.e. NERIES, NERA, TRANSFER, NEAMTIC and ASTARTE, demonstrates that collaboration of top class Research Institutions that care to produce important and useful results in the research front in Europe, can facilitate towards developing and operating top class Operational Centers, useful for Civil Protection purposes in regions in need. Last, it is demonstrated that HL-NTWC collaboration with important key role Research Centers in the Security and Safety issues (e

Neumann and Neumann-Rosochatius integrable systems from membranes on AdS4 x S7

International Nuclear Information System (INIS)

Bozhilov, Plamen

2007-01-01

It is known that large class of classical string solutions in the type IIB AdS 5 x S 5 background is related to the Neumann and Neumann-Rosochatius integrable systems, including spiky strings and giant magnons. It is also interesting if these integrable systems can be associated with some membrane configurations in M-theory. We show here that this is indeed the case by presenting explicitly several types of membrane embedding in AdS 4 x S 7 with the searched properties

Synthesis and Structures of Two Lanthanide Complexes Containing a Mixed Ligand System: [Ln(Phen){sub 2}(L){sub 3}(HL)]·H{sub 2}O [Ln = La, Ce; Phen = Phenanthroline; HL = Salicylic Acid

Energy Technology Data Exchange (ETDEWEB)

Iravani, Effat [UNiv. of Applied Science and Technology, Tehran (Iran, Islamic Republic of); Nami, Navabeh; Nabizadeh, Fatemeh; Bayani, Elham [Islamic Azad Univ., Mazandaran (Iran, Islamic Republic of); Neumueller, Bernhard [Philipps-Universitat Marburg, Marburg (Germany)

2013-11-15

The reaction of LnCl{sub 3}·7H{sub 2}O [Ln = La (1), Ce (2)] with salicylic acid (HL) and 1,10-phenanthroline (Phen) at 20 .deg. C in H{sub 2}O/ethanol gave after work-up and recrystallization two novel lanthanide complexes with general formula [Ln(Phen){sub 2}(L){sub 3}(HL)]·H{sub 2}O. Compounds 1 and 2 were characterized by IR and UV-Vis spectroscopy, TGA, CHN as well as by X-ray analysis. According to these results, compounds 1 and 2 are isostructural and contain Ln{sup 3+} ions with coordination number nine. Complexes 1 and 2 consist of two Phen, one neutral HL and three L anions (two L anions act as monodentate ligands and the third one is chelating to Ln{sup 3+}). Thermal decomposition led to primary loss of the Phen molecules. Then HL molecules and finally L moieties left the material to give Ln{sub 2}O{sub 3}.

Physics potential of ATLAS upgrades at HL-LHC

CERN Document Server

Testa, Marianna; The ATLAS collaboration

2017-01-01

The High Luminosity-Large Hadron Collider (HL-LHC) is expected to start in 2026 and to pro- vide an integrated luminosity of 3000 fb−1 in ten years, a factor 10 more than what will be collected by 2023. This high statistics will allow ATLAS to perform precise measurements in the Higgs sector and improve searches for new physics at the TeV scale. The luminosity needed is L ∼ 7.51034 cm−2 s−1, corresponding to ∼200 additional proton-proton pile- up interactions. To face such harsh environment some sub-detectors of the ATLAS experiment will be upgraded or completely substituted. The performances of the new or upgraded ATLAS sub-detectors are presented, focusing in particular on the new inner tracker and a proposed high granularity time device. The impact of those upgrades on crucial physics measurements for HL-LHC program is also shown.

Querying clinical data in HL7 RIM based relational model with morph-RDB.

Science.gov (United States)

Priyatna, Freddy; Alonso-Calvo, Raul; Paraiso-Medina, Sergio; Corcho, Oscar

2017-10-05

Semantic interoperability is essential when carrying out post-genomic clinical trials where several institutions collaborate, since researchers and developers need to have an integrated view and access to heterogeneous data sources. One possible approach to accommodate this need is to use RDB2RDF systems that provide RDF datasets as the unified view. These RDF datasets may be materialized and stored in a triple store, or transformed into RDF in real time, as virtual RDF data sources. Our previous efforts involved materialized RDF datasets, hence losing data freshness. In this paper we present a solution that uses an ontology based on the HL7 v3 Reference Information Model and a set of R2RML mappings that relate this ontology to an underlying relational database implementation, and where morph-RDB is used to expose a virtual, non-materialized SPARQL endpoint over the data. By applying a set of optimization techniques on the SPARQL-to-SQL query translation algorithm, we can now issue SPARQL queries to the underlying relational data with generally acceptable performance.

HIGH ANGULAR RESOLUTION RADIO OBSERVATIONS OF THE HL/XZ TAU REGION: MAPPING THE 50 AU PROTOPLANETARY DISK AROUND HL TAU AND RESOLVING XZ TAU S INTO A 13 AU BINARY

International Nuclear Information System (INIS)

Carrasco-Gonzalez, Carlos; Anglada, Guillem; RodrIguez, Luis F.; Curiel, Salvador

2009-01-01

We present new 7 mm and archive 1.3 cm high angular resolution observations of the HL/XZ Tau region made with the Very Large Array. At 7 mm, the emission from HL Tau seems to arise in a clumpy disk with radius of the order of 25 AU. The 1.3 cm emission from XZ Tau shows the emission from a binary system with 0.''3 (42 AU) separation, known from previous optical/IR observations. However, at 7 mm, the southern radio component resolves into a binary with 0.''09 (13 AU) separation, suggesting that XZ Tau is actually a triple star system. We suggest that the remarkable ejection of gas from the XZ Tau system observed with the Hubble Space Telescope may be related to a periastron passage of this newly discovered close binary system.

Preliminary results of MHD stability in HL-1 tokamak

International Nuclear Information System (INIS)

Zheng Yongzhen; Ma Tengcai; Xiao Zhenggui Cai Renfang

1987-01-01

In this paper, MHD activities of HL-1 tokamak plasma are studied with Fourier transform and correlatio analysis. The poloidal modes m = 1, 2, 3,4 and toroidal modes n of MHD magnetic fluctuation signals are detected. Methods for suppressing MHD instabilities are suggested and tested, after MHD instabilities are studied in HL-1. The effects of MHD characteristics in the beginning stage of discharge on the whole process of discharge are analyzed. The disruption, in HL-1 device could be divided into three kinds: internal disruption, minor disruption and major disruption. The result shows that HL-1 will have a better operation condition if internal disruption appears. In is end, the stable operation region of HL-1 tokamak is also given

Introduction to the HL-LHC Project

Science.gov (United States)

Rossi, L.; Brüning, O.

The Large Hadron Collider (LHC) is one of largest scientific instruments ever built. It has been exploring the new energy frontier since 2010, gathering a global user community of 7,000 scientists. To extend its discovery potential, the LHC will need a major upgrade in the 2020s to increase its luminosity (rate of collisions) by a factor of five beyond its design value and the integrated luminosity by a factor of ten. As a highly complex and optimized machine, such an upgrade of the LHC must be carefully studied and requires about ten years to implement. The novel machine configuration, called High Luminosity LHC (HL-LHC), will rely on a number of key innovative technologies, representing exceptional technological challenges, such as cutting-edge 11-12 tesla superconducting magnets, very compact superconducting cavities for beam rotation with ultra-precise phase control, new technology for beam collimation and 300-meter-long high-power superconducting links with negligible energy dissipation. HL-LHC federates efforts and R&D of a large community in Europe, in the US and in Japan, which will facilitate the implementation of the construction phase as a global project.

Intelligent plasma operation and control system for HL-2M

International Nuclear Information System (INIS)

Xia, F.; Chen, L.Y.; Wang, C.; Zhang, G.; Song, X.M.; Song, X.; Pan, L.; Zhao, L.; Pan, W.; Lan, J.T.

2015-01-01

Full text of publication follows. The Intelligent Plasma Operation and Control System (IPOCS) for HL-2M is under construction based on the current actual situation of HL-2A control system in SWIP. The purpose of IPOCS is to replace the routine processes before, during and post discharge with the automatic process algorithms and give various information, for example, status, warning, reason, instruction, suggestion, physics phenomenon etc. to staff who can access the intranet. In this case, the core research objectives can be focused on and the related operations can be carried out referring to the information. The ultimate goal of IPOCS is to improve the efficiency of plant operation and control and physics research for HL-2M and for the fusion reactor in the future. There are three layers in IPOCS, which are named the information collection layer, the data processing layer and the presentation layer respectively. Information collection layer consists of data acquisition system, EPICS system, Audio and Video system, discharge scheduling system, data storage system etc. All raw data are collected and stored in this layer. The data processing layer is the core of IPOCS. Most algorithms are executed here. The basic computation platform is based on cluster (56 cores at present) and Parallel Computing Toolbox provided by Matlab. The physics database for SWIP based on HDF5 and offline EFIT also locate at this layer. All the operations can be finished during the time interval between two shots. The last layer is to present the information from the former two layers. The typical hardware including the large display screen system in the control room, the voice broadcasting system, personal monitors and smart phones, etc.. Several applications has being developed such as Control System Studio (CSS) in SWIP version, WebOPI, Automatic Alarm Display system and so on. IPOCS for HL-2M is at the very beginning phase at present. With more and more systems and algorithms got

HL-217, a new topical anti-angiogenic agent, inhibits retinal vascular leakage and pathogenic subretinal neovascularization in Vldlr−/− mice

International Nuclear Information System (INIS)

Kim, Junghyun; Kim, Chan-Sik; Jo, Kyuhyung; Cho, Yun-Seok; Kim, Hyun-Gyu; Lee, Geun-Hyeog; Lee, Yun Mi; Sohn, Eunjin; Kim, Jin Sook

2015-01-01

Highlights: • HL-217 is a new synthetic topical anti-angiogenic agent. • HL-217 attenuated subretinal neovascularization in Vldlr −/− mice. • HL-217 blocked the binding of PDGF-BB to PDGFRβ. - Abstract: HL-217 is a new synthetic angiogenesis inhibitor. Platelet derived growth factor (PDGF) is a vasoactive factor and has been implicated in proliferative retinopathies. In this study, we examined the mechanism of action and efficacy of topical application of HL-217 on subretinal neovascularization in very low-density lipoprotein receptor knockout (Vldlr −/− ) mice. In three-week-old male Vldlr −/− mice, HL-217 (1.5 or 3 mg/ml) was administered twice per day for 4 weeks by topical eye drop instillation. Neovascular areas were then measured. We used a protein array to evaluate the expression levels of angiogenic factors. The inhibitory effect of HL-217 on the PDGF-BB/PDGFRβ interaction was evaluated in vitro. The neovascular area in the Vldlr −/− mice was significantly reduced by HL-217. Additionally, HL-217 decreased the expression levels of PDGF-BB protein and VEGF mRNA. Moreover, HL-217 dose-dependently inhibited the PDGF-BB/PDGFRβ interaction (IC 50 = 38.9 ± 0.7 μM). These results suggest that HL-217 is a potent inhibitor of PDGF-BB. HL-217, when applied topically, is an effective inhibitor of subretinal neovascularization due to its ability to inhibit the pro-angiogenic effects of PDGF-BB

Future Plans of the ATLAS Collaboration for the HL-LHC

CERN Document Server

Hristova, Ivana; The ATLAS collaboration

2018-01-01

These proceedings report the current plans to upgrade the ATLAS detector at CERN for the High Luminosity LHC (HL-LHC). The HL-LHC is expected to start operations in the middle of 2026, aiming to reach an ultimate peak instantaneous luminosity of 7.5$\\times10^{34}$cm$^{-2}$s$^{-1}$, corresponding to approximately 200 inelastic proton-proton collisions per bunch crossing, and to deliver over a period of twelve years more than ten times the integrated luminosity of the large hadron collider (LHC) Runs 1-3 combined (up to $4000$ fb$^{-1}$). This is a huge challenge to all sub-systems of the detector which will need extensive upgrades to allow the experiment to pursue a rich and interesting physics programme in the future.

99MTC-HL91 spect image versus 18F-FDG PET for detection of head and neck carcinoma

International Nuclear Information System (INIS)

Chu, L.S.; Liu, R.S.; Chou, K.L.; Yang, B.H.; Liao, S.Q.; Yeh, S.H.

2004-01-01

Objective: Tumor hypoxia is a major complication of oncologic cell switch for chemotherapy(C/T) and / or radiotherapy(R/T). Such lesions detected by selective modem conventional examination remains difficult. 99mTc-HL91 is a potential agent for imaging hypoxic tissue in vivo. This study aimed to assess efficacy of 99mTc- HL91 in imaging of head and neck cancer and compared the result with 18F-fluorodeoxyglucose(FDG)PET. Methods: Sixteen pts with head and neck cancers (7 hypopharyngeal cancers, 4 laryngeal cancers, 5 tongue base cancers) were enrolled in this study. Primary tumors and suspicious local,regional metastases were diagnosed by clinical examination, CT/MRI , and biopsy. After intravenous injection of 740 MBq of 99mTc-HL91, whole body planar scan and regional SPECT at 2hr postinjection were performed. Tumor lesion -to- normal background(T/N) ratios with 3x3 pixels of background ROI were also measured. The reference range of T/N ratio greater 3.0 defined +, close to 2.4 defined +/- and less than 1.5 defined as -. The FDG images with dedicated PET system was performed at 4hr after completion of 99mTc-HL91 study. The visualized tumors uptake with ratio of standardized uptake value (SUV) greater than 2.5 defined as +.. less than 2.5 defined -. Results: In 7 hypopharyngeal cancers, there are 2FDG+/HL91+, 3FDG+/HL91-, 2FDG+/HL91+/-, In 4 laryngeal cancers, there are 3FDG+/HL91-, 1FDG+/HL91 +/-. In 5 tongue base cancers, there are 5FDG+/HL91-.(Table 1). The T/N ratios of all head and neck cancers in primary tumor and regional lymph nodes were ranged from l.3/1.5 and 1.1/1.2 respectively. The frequency of FDG + in hypopharyngeal cancers is 1.0,in laryngeal cancers is 1.0 and in tongue base cancers is 1.0. The frequency of HL91+/+/- in hypopharyngeal cancers is 0..58,in laryngeal cancers is 0.25.and in tongue base cancers is 0. The overall detection rate of head and neck cancer by FDG+ in this study is 100% and overall detection rate of local-regional hypoxia, by

Physics design of the HL-2A tokamak

International Nuclear Information System (INIS)

Gao Qingdi; Li Fangzhu; Zhang Jinhua; Pan Yudong; Jiao Yiming

2005-10-01

An overview report for the physics design of the HL-2A tokamak is presented. By numerically analyzing the plasma shaping and the vertical instability due to plasma elongation, the requirements for the currents of poloidal magnetic field coils and the control system are put forward. Controlling the plasma profile by using NBI (neutral beam injection) and LHCD (lower hybrid current drive) is investigated, and the high performance modes of operation in HL-2A and modeled and designed. The magnetohydrodynamic instabilities in improved confinement configuration (RS configuration) are studied so as to point out the way of plasma control to perform stationary high performance discharges in HL-2A. In order to offer data for updating the HL-2A divertor, performances of the divertor plasma are simulated. (authors)

HL-LHC updates in Japan

CERN Multimedia

Antonella Del Rosso

2014-01-01

At a recent meeting in Japan, updates on the High Luminosity LHC (HL-LHC) project were presented, including the progress made so far and the deadlines still to be met for the upgraded machine to be operational from 2020.   New magnets made with advanced superconductor Nb3Sn in the framework of the HL-LHC project. These magnets are currently under construction at CERN by the TE-MSC group. The LHC is the world’s most powerful particle accelerator, and in 2015 it will reach yet another new record for the energy of its colliding beams. One key factor of its discovery potential is its ability to produce collisions described in mathematical terms by the parameter known as “luminosity”. In 2025, the HL-LHC project will allow the total number of collisions in the LHC to increase by a factor of 10. The first step in this rich upgrade programme is the delivery of the Preliminary Design Report (PDR), which is also a key milestone of the HiLumi LHC Design Study partly fund...

Isolation of HL-60 cancer cells from the human serum sample using MnO2-PEI/Ni/Au/aptamer as a novel nanomotor and electrochemical determination of thereof by aptamer/gold nanoparticles-poly(3,4-ethylene dioxythiophene) modified GC electrode.

Science.gov (United States)

Amouzadeh Tabrizi, Mahmoud; Shamsipur, Mojtaba; Saber, Reza; Sarkar, Saeed

2018-07-01

Herein, aptamer-modified self-propelled nanomotors were used for transportation of human promyelocytic leukemia cells (HL-60) from a human serum sample. For this purpose, the fabricated manganese oxide nanosheets-polyethyleneimine decorated with nickel/gold nanoparticles (MnO 2 -PEI/Ni/Au) as nanomotors were added to a vial containing thiolated aptamer KH1C12 solution as a capture aptamer to attach to the gold nanoparticles on the surface of nanomotors covalently. The aptamer-modified self-propelled nanomotors (aptamer KH1C12 /nanomotors) were then separated by placing the vial in a magnetic stand. The aptamer-modified self-propelled nanomotors were rinsed three times with water to remove the non-attached aptamers. Then, the resulting aptamer KH1C12 /nanomotors were applied for the on-the-fly" transporting of HL-60 cancer cell from a human serum sample. To release of the captured HL-60 cancer cells, the complementary nucleotide sequences of KH1C12 aptamer solution (releasing aptamer) that has a with capture aptamer was added to phosphate buffer solution (1 M, pH 7.4) containing HL-60/aptamer KH1C12 /nanomotors. Because of the high affinity of capture aptamer to complementary nucleotide sequences of aptamer KH1C12 , the HL-60 cancer cells released on the surface of aptamer KH1C12 /nanomotors into the solution. The second goal of the present work was determining the concentration of HL-60 cancer cell in the human serum samples. The electrochemical impedance spectroscopy technique (EIS) was used for the determination of HL-60 cancer cell. The concentration of separated cancer cell was determined by aptamer/gold nanoparticles-poly(3,4-ethylene dioxythiophene) modified GC electrode (GC/PEDOT-Au nano /aptamer KH1C12 ). The proposed aptasensor exhibited a good response to the concentration of HL-60 cancer cells in the range of 2.5 × 10 1 to 5 × 10 5 cells mL -1 with a low limit of detection of 250 cells mL -1 . Copyright © 2018 Elsevier B.V. All rights reserved.

16 CFR 460.7 - Which test version to use.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Which test version to use. 460.7 Section 460.7 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES LABELING AND ADVERTISING OF... automatically replace the old one in these rules 90 days after ASTM first publishes the change. However, the...

Vildagliptin and its metabolite M20.7 induce the expression of S100A8 and S100A9 in human hepatoma HepG2 and leukemia HL-60 cells.

Science.gov (United States)

Asakura, Mitsutoshi; Karaki, Fumika; Fujii, Hideaki; Atsuda, Koichiro; Itoh, Tomoo; Fujiwara, Ryoichi

2016-10-19

Vildagliptin is a potent, orally active inhibitor of dipeptidyl peptidase-4 (DPP-4) for the treatment of type 2 diabetes mellitus. It has been reported that vildagliptin can cause hepatic dysfunction in patients. However, the molecular-mechanism of vildagliptin-induced liver dysfunction has not been elucidated. In this study, we employed an expression microarray to determine hepatic genes that were highly regulated by vildagliptin in mice. We found that pro-inflammatory S100 calcium-binding protein (S100) a8 and S100a9 were induced more than 5-fold by vildagliptin in the mouse liver. We further examined the effects of vildagliptin and its major metabolite M20.7 on the mRNA expression levels of S100A8 and S100A9 in human hepatoma HepG2 and leukemia HL-60 cells. In HepG2 cells, vildagliptin, M20.7, and sitagliptin - another DPP-4 inhibitor - induced S100A9 mRNA. In HL-60 cells, in contrast, S100A8 and S100A9 mRNAs were significantly induced by vildagliptin and M20.7, but not by sitagliptin. The release of S100A8/A9 complex in the cell culturing medium was observed in the HL-60 cells treated with vildagliptin and M20.7. Therefore, the parental vildagliptin- and M20.7-induced release of S100A8/A9 complex from immune cells, such as neutrophils, might be a contributing factor of vildagliptin-associated liver dysfunction in humans.

Code development and analysis program. RELAP4/MOD7 (Version 2): user's manual

International Nuclear Information System (INIS)

1978-08-01

This manual describes RELAP4/MOD7 (Version 2), which is the latest version of the RELAP4 LPWR blowdown code. Version 2 is a precursor to the final version of RELAP4/MOD7, which will address LPWR LOCA analysis in integral fashion (i.e., blowdown, refill, and reflood in continuous fashion). This manual describes the new code models and provides application information required to utilize the code. It must be used in conjunction with the RELAP4/MOD5 User's Manual (ANCR-NUREG-1335, dated September 1976), and the RELAP4/MOD6 User's Manual

HL-217, a new topical anti-angiogenic agent, inhibits retinal vascular leakage and pathogenic subretinal neovascularization in Vldlr{sup −/−} mice

Energy Technology Data Exchange (ETDEWEB)

Kim, Junghyun; Kim, Chan-Sik; Jo, Kyuhyung [Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of); Cho, Yun-Seok; Kim, Hyun-Gyu; Lee, Geun-Hyeog [Research and Development Center, Hanlim Pharm. Co. Ltd., 1656-10, Seocho-dong, Seocho-gu, Seoul (Korea, Republic of); Lee, Yun Mi; Sohn, Eunjin [Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of); Kim, Jin Sook, E-mail: jskim@kiom.re.kr [Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of)

2015-01-02

Highlights: • HL-217 is a new synthetic topical anti-angiogenic agent. • HL-217 attenuated subretinal neovascularization in Vldlr{sup −/−} mice. • HL-217 blocked the binding of PDGF-BB to PDGFRβ. - Abstract: HL-217 is a new synthetic angiogenesis inhibitor. Platelet derived growth factor (PDGF) is a vasoactive factor and has been implicated in proliferative retinopathies. In this study, we examined the mechanism of action and efficacy of topical application of HL-217 on subretinal neovascularization in very low-density lipoprotein receptor knockout (Vldlr{sup −/−}) mice. In three-week-old male Vldlr{sup −/−} mice, HL-217 (1.5 or 3 mg/ml) was administered twice per day for 4 weeks by topical eye drop instillation. Neovascular areas were then measured. We used a protein array to evaluate the expression levels of angiogenic factors. The inhibitory effect of HL-217 on the PDGF-BB/PDGFRβ interaction was evaluated in vitro. The neovascular area in the Vldlr{sup −/−} mice was significantly reduced by HL-217. Additionally, HL-217 decreased the expression levels of PDGF-BB protein and VEGF mRNA. Moreover, HL-217 dose-dependently inhibited the PDGF-BB/PDGFRβ interaction (IC{sub 50} = 38.9 ± 0.7 μM). These results suggest that HL-217 is a potent inhibitor of PDGF-BB. HL-217, when applied topically, is an effective inhibitor of subretinal neovascularization due to its ability to inhibit the pro-angiogenic effects of PDGF-BB.

Optics Measurements and Correction Challenges for the HL-LHC

CERN Document Server

Carlier, Felix Simon; Fartoukh, Stephane; Fol, Elena; Gamba, Davide; Garcia-Tabares Valdivieso, Ana; Giovannozzi, Massimo; Hofer, Michael; Langner, Andy Sven; Maclean, Ewen Hamish; Malina, Lukas; Medina Medrano, Luis Eduardo; Persson, Tobias Hakan Bjorn; Skowronski, Piotr Krzysztof; Tomas Garcia, Rogelio; Van Der Veken, Frederik; Wegscheider, Andreas

2017-01-01

Optics control in the HL-LHC will be challenged by a very small β* of 15 cm in the two main experiments. HL-LHC physics fills will keep a constant luminosity during several hours via β* leveling. This will require the commissioning of a large number of optical configurations, further challenging the efficiency of the optics measurements and correction tools. We report on the achieved level of optics control in the LHC with simulations and extrapolations for the HL-LHC.

Acridones as inducers of HL-60 cell differentiation.

Science.gov (United States)

Kawaii, S; Tomono, Y; Katase, E; Ogawa, K; Yano, M; Takemura, Y; Ju-ichi, M; Ito, C; Furukawa, H

1999-03-01

Fifteen acridone alkaloids were examined for their activity of induction of human promyelocytic leukemia cell (HL-60) differentiation. HL-60 cells were differentiated into mature monocyte/macrophage by atalaphyllidine (9), atalaphyllinine (12), and des-N-methylnoracronycine (13). The activities of NBT reduction, nonspecific esterase, and phagocytosis, were induced by 2.5 microM of 9, 12, and 13. After a 4-day treatment, 9, 12, and 13 at 10 microM inhibited clonal proliferation of HL-60 cells by 28, 96, and 63%, respectively. The structure-activity relationship established from the results revealed that hydroxyl group at C-1 and prenyl group at C-2 had an important role.

Experimental study of 99Tcm-HL91 and 99Tcm-MIBI in mice bearing Lewis lung cancer

International Nuclear Information System (INIS)

Han Chunqi; Li Yaming; Ren Yangang; Yi Lijie

2000-01-01

Objective: To evaluate the ability of detecting lung cancer by 99 Tc m -HL91 and 99 Tc m -MIBI in mice bearing Lewis lung cancer. Methods: Four model mice underwent whole body planar imaging at 2 h, 4 h after injection of 99 Tc m -MIBI; four mice underwent whole body planar imaging at 2 h and 4 h after injection of 99 Tc m -HL91, and the mice of the 99 Tc m -HL91 group were then killed, the tumor, blood and organs were removed, weighted and the radioactivity was measured. ROIs were drawn around the tumor, head and chest in whole body planar images, and radioactivity ratios of tumor to head (T/H), chest (T/C) and contralateral limbs (T/L) were calculated. Results: No significant tumor radioactivity in 2 h and 4 h images of 99 Tc m -MIBI mice (T/C: 0.20 +- 0.08 and 0.14 +- 0.07) was found; increased tumor radioactivity was identified in images of 99 Tc m -HL91 mice (T/C: 3.25 +- 1.25 and 2.44 +- 1.07), and there was significant difference (t = 4.8 - 7.5, P 99 Tc m -HL91 in tumor tissue of mice is higher and clearance rate is slower. 99 Tc m -HL91 is a valuable tumor imaging agent for clinical diagnosis for the cancer

Fast crab cavity failures in HL-LHC

CERN Document Server

Yee-Rendon, B; Calaga, R; Tomas, R; Zimmermann, F; Barranco, J

2014-01-01

Crab cavities (CCs) are a key ingredient of the High-Luminosity Large Hadron Collider (HL-LHC) to ensure head on collisions at the main experiments (ATLAS and CMS) and fully profit from the smaller provided by the ATS optics [1]. At KEKB, CCs have exhibited abrupt changes of phase and voltage during a time period of few LHC turns and considering the large energy stored in the HL-LHC beam, CC failures represent a serious risk to the LHC machine protection. In this paper, we discuss the effect of CC voltage or phase changes on a time interval similar to, or longer than, the one needed to dump the beam. The simulations assume a realistic steady-state distribution to assess the beam losses for the HL-LHC. Additionally, some strategies are studied in order to reduce the damage caused by the CC failures.

A Document-Based EHR System That Controls the Disclosure of Clinical Documents Using an Access Control List File Based on the HL7 CDA Header.

Science.gov (United States)

Takeda, Toshihiro; Ueda, Kanayo; Nakagawa, Akito; Manabe, Shirou; Okada, Katsuki; Mihara, Naoki; Matsumura, Yasushi

2017-01-01

Electronic health record (EHR) systems are necessary for the sharing of medical information between care delivery organizations (CDOs). We developed a document-based EHR system in which all of the PDF documents that are stored in our electronic medical record system can be disclosed to selected target CDOs. An access control list (ACL) file was designed based on the HL7 CDA header to manage the information that is disclosed.

Radiological Safety Analysis Computer (RSAC) Program Version 7.0 Users’ Manual

Energy Technology Data Exchange (ETDEWEB)

Dr. Bradley J Schrader

2009-03-01

The Radiological Safety Analysis Computer (RSAC) Program Version 7.0 (RSAC-7) is the newest version of the RSAC legacy code. It calculates the consequences of a release of radionuclides to the atmosphere. A user can generate a fission product inventory from either reactor operating history or a nuclear criticality event. RSAC-7 models the effects of high-efficiency particulate air filters or other cleanup systems and calculates the decay and ingrowth during transport through processes, facilities, and the environment. Doses are calculated for inhalation, air immersion, ground surface, ingestion, and cloud gamma pathways. RSAC-7 can be used as a tool to evaluate accident conditions in emergency response scenarios, radiological sabotage events and to evaluate safety basis accident consequences. This users’ manual contains the mathematical models and operating instructions for RSAC-7. Instructions, screens, and examples are provided to guide the user through the functions provided by RSAC-7. This program was designed for users who are familiar with radiological dose assessment methods.

Radiological Safety Analysis Computer (RSAC) Program Version 7.2 Users’ Manual

Energy Technology Data Exchange (ETDEWEB)

Dr. Bradley J Schrader

2010-10-01

The Radiological Safety Analysis Computer (RSAC) Program Version 7.2 (RSAC-7) is the newest version of the RSAC legacy code. It calculates the consequences of a release of radionuclides to the atmosphere. A user can generate a fission product inventory from either reactor operating history or a nuclear criticality event. RSAC-7 models the effects of high-efficiency particulate air filters or other cleanup systems and calculates the decay and ingrowth during transport through processes, facilities, and the environment. Doses are calculated for inhalation, air immersion, ground surface, ingestion, and cloud gamma pathways. RSAC-7 can be used as a tool to evaluate accident conditions in emergency response scenarios, radiological sabotage events and to evaluate safety basis accident consequences. This users’ manual contains the mathematical models and operating instructions for RSAC-7. Instructions, screens, and examples are provided to guide the user through the functions provided by RSAC-7. This program was designed for users who are familiar with radiological dose assessment methods.

Radiological Safety Analysis Computer (RSAC) Program Version 7.0 Users Manual

International Nuclear Information System (INIS)

Schrader, Bradley J.

2009-01-01

The Radiological Safety Analysis Computer (RSAC) Program Version 7.0 (RSAC-7) is the newest version of the RSAC legacy code. It calculates the consequences of a release of radionuclides to the atmosphere. A user can generate a fission product inventory from either reactor operating history or a nuclear criticality event. RSAC-7 models the effects of high-efficiency particulate air filters or other cleanup systems and calculates the decay and ingrowth during transport through processes, facilities, and the environment. Doses are calculated for inhalation, air immersion, ground surface, ingestion, and cloud gamma pathways. RSAC-7 can be used as a tool to evaluate accident conditions in emergency response scenarios, radiological sabotage events and to evaluate safety basis accident consequences. This users manual contains the mathematical models and operating instructions for RSAC-7. Instructions, screens, and examples are provided to guide the user through the functions provided by RSAC-7. This program was designed for users who are familiar with radiological dose assessment methods

The Design of Dual-Emissive Composite Material [Zn2(HL)3]+@MOF-5 as Self-Calibrating Luminescent Sensors of Al3+ Ions and Monoethanolamine.

Science.gov (United States)

Wu, Meng-Meng; Wang, Jiao-Yang; Sun, Rui; Zhao, Cui; Zhao, Jiong-Peng; Che, Guang-Bo; Liu, Fu-Chen

2017-08-21

Introducing another chromophore into a luminescent MOF is a potential way to assembling novel dual-emissive luminescent materials. Putting the chromophore, for which luminescence can be enhanced by Zn 2+ ion, into MOF-5 by the "bottle around ship" strategy is a simple but efficient synthesis method to realize such dual-emissive materials. According to this strategy, a novel dual-emissive luminescent composite material [Zn 2 (HL) 3 ] + @MOF-5 was constructed by loading the [La 3 (HL) 2 L 2 (NO 3 ) 3 H 2 O] (1) (H 2 L = 7,7'-(ethane-1,1'-diyl)8-hydro-quinoline) into MOF-5, in which the [Zn 2 (HL) 3 ] + anions were transformed from 1 with the existence of Zn 2+ . The dual-emissive composite materials show excellent luminescence with two emissions of MOF-5 at 410 nm and [Zn 2 (HL) 3 ] + at 524 nm. Furthermore, by combining characteristics of MOF-5 and the guest chromophore, the composite material is highly selectively sensitive toward Al 3+ and monoethanolamine, which makes [Zn 2 (HL) 3 ] + @MOF-5 a potential self-calibrated fluorescence sensor.

Time-dependent AdS backgrounds from S-branes

Energy Technology Data Exchange (ETDEWEB)

Deger, Nihat Sadik, E-mail: sadik.deger@boun.edu.tr [Department of Mathematics, Bogazici University, Bebek, 34342, Istanbul (Turkey); Feza Gursey Center for Physics and Mathematics, Bogazici University, Kandilli, 34684, Istanbul (Turkey)

2016-11-10

We construct time and radial dependent solutions that describe p-branes in chargeless S-brane backgrounds. In particular, there are some new M5- and D3-branes among our solutions which have AdS limits and contain a cosmological singularity as well. We also find a time-dependent version of the dyonic membrane configuration in 11-dimensions by applying a Lunin–Maldacena deformation to our new M5-brane solution.

Spontaneous release of soluble HL-A antigens from platelets during conservation.

Science.gov (United States)

Dautigny, A; Bernier, I; Colombani, J; Jollès, P

1975-01-01

Experiments with the aim of studying the solubilisation of HL-A antigens from blood platelets by methods which do not involve any biologically active processes (moderate, discontinuous agitation of a low concentration of platelets suspended in a saline medium, in the presence of an antiseptic; supernatants collected at frequent intervals) have shown that platelets release membrane proteins, including HL-A antigens, spontaneously. Optimal conditions for the treatment of membrane proteins have been perfected. The great stability of HL-A antigens under these conditions permits prolonged treatment. The products extracted are soluble and extremely complex. The molecular weight of the HL-A antigens is between 40,000 and 70,000.

Cytotoxicity and cellular uptake of doxorubicin and its formamidine derivatives in HL60 sensitive and HL60/MX2 resistant cells.

Science.gov (United States)

Kik, Krzysztof; Wasowska-Lukawska, Malgorzata; Oszczapowicz, Irena; Szmigiero, Leszek

2009-04-01

In this work a comparison was made of the cytotoxicity and cellular uptake of doxorubicin (DOX) and two of its derivatives containing a formamidino group (-N=CH-N<) at the 3' position with morpholine (DOXM) or hexamethyleneimine (DOXH) ring. All tests were performed in doxorubicin-sensitive HL60 and -resistant HL60/MX2 cells which are known for the presence of altered topoisomerase II. Cytotoxic activity of DOX toward HL60/MX2 cells was about 195 times lower when compared with the sensitive HL60 cell line. DOXM and DOXH were approximately 20 times more active in resistant cells than DOX. It was found that the uptake of DOX was lower in resistant cells by about 16%, while that of DOXM and DOXH was lower by about 36% and 19%, respectively. Thus the changes in the cellular uptake of anthracyclines are not associated with the fact that cytotoxicity of DOXM and DOXH exceed the cytotoxicity of DOX. Experiments in cell-free system containing human topoisomerase II showed that topoisomerase II is not inhibited by DOXM and DOXH. Formamidinoanthracyclines may be more useful than parent drugs in therapy against tumor cells with altered topoisomerase II activity.

Evidence for Transfer of Membranes from Mesenchymal Stem Cells to HL-1 Cardiac Cells.

Science.gov (United States)

Boomsma, Robert A; Geenen, David L

2014-01-01

This study examined the interaction of mouse bone marrow mesenchymal stem cells (MSC) with cardiac HL-1 cells during coculture by fluorescent dye labeling and then flow cytometry. MSC were layered onto confluent HL-1 cell cultures in a 1 : 4 ratio. MSC gained gap junction permeant calcein from HL-1 cells after 4 hours which was partially reduced by oleamide. After 20 hours, 99% MSC gained calcein, unaffected by oleamide. Double-labeling HL-1 cells with calcein and the membrane dye DiO resulted in transfer of both calcein and DiO to MSC. When HL-1 cells were labeled with calcein and MSC with DiO, MSC gained calcein while HL-1 cells gained DiO. Very little fusion was observed since more than 90% Sca-1 positive MSC gained DiO from HL-1 cells while less than 9% gained gap junction impermeant CMFDA after 20 hours with no Sca-1 transfer to HL-1 cells. Time dependent transfer of membrane DiD was observed from HL-1 cells to MSC (100%) and vice versa (50%) after 20 hours with more limited transfer of CMFDA. These results demonstrate that MSC and HL-1 cells exchange membrane components which may account for some of the beneficial effect of MSC in the heart after myocardial infarction.

Initial analysis of the HL-2A tokamak visible light measurements

International Nuclear Information System (INIS)

Shi Le; Zheng Yinjia

2005-01-01

Measurement of H α radial distribution is an important part in a plasma experiment. During the HL-2A experiment, CCD photos recorded the plasma radiation information using a plasma imaging system, particularly the H α line emission information (with H α filter in front of the camera). Since the line of light radiation measurement involves a line integral of the radiating region, data handling and analysis are necessary. The H α radial distribution along an HL-2A tokamak radial radius can be obtained by using an Abel inversion transformation with plasma imaging on the HL-2A tokamak. This paper provides a reliable measurement method on the HL-2A tokamak. (authors)

Synthesis and Biological Activity of Diastereomeric and Geometric Analogs of Calcipotriol, PRI-2202 and PRI-2205, Against Human HL-60 Leukemia and MCF-7 Breast Cancer Cells.

Science.gov (United States)

Milczarek, Magdalena; Chodyński, Michał; Filip-Psurska, Beata; Martowicz, Agnieszka; Krupa, Małgorzata; Krajewski, Krzysztof; Kutner, Andrzej; Wietrzyk, Joanna

2013-10-31

Diastereomeric and geometric analogs of calcipotriol, PRI-2202 and PRI-2205, were synthesized as advanced intermediates from vitamin D C-22 benzothiazoyl sulfones and side-chain aldehydes using our convergent strategy. Calcitriol, calcipotriol (PRI-2201) and tacalcitol (PRI-2191) were used as the reference compounds. Among a series of tested analogs the diastereomeric analog PRI-2202 showed the strongest antiproliferative activity on the human breast cancer cell line MCF-7, whereas the geometric analog PRI-2205 was the weakest. Both analogs were less potent in antiproliferative activity against HL-60 cells compared to the reference compounds. The ability to potentiate antiproliferative effect of cisplatin or doxorubicin against HL-60 cells or that of tamoxifen against the MCF-7 cell line was observed at higher doses of PRI-2202 or PRI-2205 than those of the reference compounds. The proapoptotic activity of tamoxifen, expressed as the diminished mitochondrial membrane potential, as well as the increased phosphatidylserine expression, was partially attenuated by calcitriol, PRI-2191, PRI-2201 and PRI-2205. The treatment of the MCF-7 cells with tamoxifen alone resulted in an increase in VDR expression. Moreover, a further increase in VDR expression was observed when the analogs PRI-2201 or PRI-2205, but not PRI-2191, were used in combination with tamoxifen. This observation could partially explain the potentiation of the antiproliferative effect of tamoxifen by vitamin D analogs.

Connecting HL Tau to the observed exoplanet sample

Science.gov (United States)

Simbulan, Christopher; Tamayo, Daniel; Petrovich, Cristobal; Rein, Hanno; Murray, Norman

2017-08-01

The Atacama Large Millimeter/submilimeter Array (ALMA) recently revealed a set of nearly concentric gaps in the protoplanetary disc surrounding the young star HL Tauri (HL Tau). If these are carved by forming gas giants, this provides the first set of orbital initial conditions for planets as they emerge from their birth discs. Using N-body integrations, we have followed the evolution of the system for 5 Gyr to explore the possible outcomes. We find that HL Tau initial conditions scaled down to the size of typically observed exoplanet orbits naturally produce several populations in the observed exoplanet sample. First, for a plausible range of planetary masses, we can match the observed eccentricity distribution of dynamically excited radial velocity giant planets with eccentricities >0.2. Secondly, we roughly obtain the observed rate of hot Jupiters around FGK stars. Finally, we obtain a large efficiency of planetary ejections of ≈2 per HL Tau-like system, but the small fraction of stars observed to host giant planets makes it hard to match the rate of free-floating planets inferred from microlensing observations. In view of upcoming Gaia results, we also provide predictions for the expected mutual inclination distribution, which is significantly broader than the absolute inclination distributions typically considered by previous studies.

Raman spectrum reveals Mesenchymal stem cells inhibiting HL60 cells growth

Science.gov (United States)

Su, Xin; Fang, Shaoyin; Zhang, Daosen; Zhang, Qinnan; Lu, Xiaoxu; Tian, Jindong; Fan, Jinping; Zhong, Liyun

2017-04-01

Though some research results reveals that Mesenchymal stem cells (MSCs) have the ability of inhibiting tumor cells proliferation, it remains controversial about the precise interaction mechanism during MSCs and tumor cells co-culture. In this study, combing Raman spectroscopic data and principle component analysis (PCA), the biochemical changes of MSCs or Human promyelocytic leukemia (HL60) cells during their co-culture were presented. The obtained results showed that some main Raman peaks of HL60 assigned to nucleic acids or proteins were greatly higher in intensity in the late stage of co-culture than those in the early stage of co-culture while they were still lower relative to the control group, implicating that the effect of MSCs inhibiting HL60 proliferation appeared in the early stage but gradually lost the inhibiting ability in the late stage of co-culture. Moreover, some other peaks of HL60 assigned to proteins were decreased in intensity in the early stage of co-culture relative to the control group but rebounded to the level similar to the control group in the late stage, showing that the content and structure changes of these proteins might be generated in the early stage but returned to the original state in the late stage of co-culture. As a result, in the early stage of MSCs-HL60 co-culture, along with the level of Akt phosphorylation of HL60 was lowered relative to its control group, the proliferation rate of HL60 cells was decreased. And in the late stage of co-culture, along with the level of Akt phosphorylation was rebounded, the reverse transfer of Raman peaks within 875-880 cm- 1 appeared, thus MSCs lost the ability to inhibit HL60 growth and HL60 proliferation was increased. In addition, it was observed that the peak at 811 cm- 1, which is a marker of RNA, was higher in intensity in the late stage than that in the control group, indicating that MSCs might be differentiated into myofibroblast-like MSCs. In addition, PCA results also exhibited

TRMM Version 7 Level 3 Gridded Monthly Accumulations of GPROF Precipitation Retrievals

Science.gov (United States)

Stocker, E. F.; Kelley, O. A.

2012-01-01

In July 2011, improved versions of the retrieval algorithms were approved for TRMM. All data starting with June 2011 are produced only with the version 7 code. At the same time, version 7 reprocessing of all TRMM mission data was started. By the end of August 2011, the 14+ years of the reprocessed mission data became available online to users. This reprocessing provided the opportunity to redo and enhance upon an analysis of V7 impacts on L3 data accumulations that was presented at the 2010 EGU General Assembly. This paper will discuss the impact of algorithm changes made in th GPROF retrieval on the Level 2 swath products. Perhaps the most important change in that retrieval was to replacement of a model based a priori database with one created from Precipitation Radar (PR) and TMI brightness temperature (Tb) data. The radar pays a major role in the V7 GPROF (GPROF2010) in determining existence of rain. The level 2 retrieval algorithm also introduced a field providing the probability of rain. This combined use of the PR has some impact on the retrievals and created areas, particularly over ocean, where many areas of low-probability precipitation are retrieved whereas in version 6, these areas contained zero rain rates. This paper will discuss how these impacts get translated to the space/time averaged monthly products that use the GPROF retrievals. The level 3 products discussed are the gridded text product 3G68 and the standard 3A12 and 3B31 products. The paper provides an overview of the changes and explanation of how the level 3 products dealt with the change in the retrieval approach. Using the .25 deg x .25 degree grid, the paper will show that agreement between the swath product and the level 3 remains very high. It will also present comparisons of V6 and V7 GPROF retrievals as seen both at the swath level and the level 3 time/space gridded accumulations. It will show that the various L3 products based on GPROF level 2 retrievals are in close agreement. The

[Drug resistance reversal of HL-60/ADR cells by simultaneous suppression of XIAP and MRP].

Science.gov (United States)

Wang, Xiao-Fang; Wang, Chun; Qin, You-Wen; Yan, Shi-Ke; Gao, Yan-Rong

2006-12-01

This study was purposed to explore the mechanisms of drug resistance of HL-60/ADR cells and to compare the reversal drug-resistance effects of antisense oligonucleotides (AS ODN) of XIAP (X-linked inhibitor of apoptosis protein) and AS ODNs of MRP (multidrug resistance-associated protein) by use alone or in combination. Reverse transcription-PCR and Western blot were applied to detect the expression of XIAP, BCL-2, MRP and MDR1 in mRNA and protein levels of HL-60 cells and HL-60/ADR cells, respectively. Fully phosphorothioated AS ODN of XIAP and MRP was delivered into HL-60/ADR cells with Lipofectamine 2000 in the form of liposome-ODN complexes alone or in combination. CCK-8 cell viability assay was used to determine the effect of AS ODN of XIAP and MRP used alone or in combination on the chemotherapy sensitivity of HL-60/ADR cells to daunorubicin (DNR). Reverse transcription-PCR and Western blot were applied to examine the changes of XIAP, MRP in mRNA and protein levels respectively. The results showed that MRP and XIAP were both significantly higher in HL-60/ADR cells than those in HL-60 cells. AS ODN of XIAP and MRP down-regulated the expression of XIAP and MRP in HL-60/ADR cells and increased the sensitivity of HL-60/ADR cells to DNR, respectively. AS ODN of XIAP + MRP did not enhance the inhibition expression of XIAP in HL-60/ADR cells but increased the sensitivity of HL-60/ADR cells to DNR significantly as compared with AS ODN of XIAP (P MRP did not increase the concentration of DNR nor enhanced the inhibition expression of MRP in HL-60/ADR cells but increased the sensitivity of HL-60/ADR cells to DNR significantly (P MRP. It is concluded that both XIAP and MRP may be involved in the drug resistance mechanisms of HL-60/ADR cells. Drug-resistance of HL-60/ADR cells can be reversed significantly when antisense oligonucleotides of XIAP and MRP were used in combination.

An experimental study of 99Tcm-PnAO-nitroimidazole and 99Tcm-HL91 in detection of myocardial hypoxia

International Nuclear Information System (INIS)

Yao Zhiming; Liu Xiujie; Shi Rongfang; Guo Feng; Liu Yunzhong; Wang Qi; Wei Hongxing; Zhu Lin

1999-01-01

Objective: To investigate the biological characteristics of two hypoxic-avid imaging agents, 99 Tc m -PnAO-nitroimidazole and 99 Tc m -HL91, and the experimental myocardial hypoxia, low perfusion and ischemic reperfusion were performed. Methods: Isolated rat hearts were retrograde perfused with Kerbs-Henscleit buffer (KH) in four phantoms: control, low perfusion, ischemic reperfusion and hypoxia. Control hearts were perfused with 95% O 2 and 5% CO 2 balanced KH at 9∼10 mL/min rate. Low perfusion hearts were perfused with the same KH at 1 mL/min rate, and ischemic reperfusion rat hearts were discontinued perfusion for 20 min then reperfused with the same KH. Hypoxic hearts were perfused with 100% N 2 balanced KH. Results: 1) At 30 and 60 min, the radioactivity ratio of liver to heart (L/H) was 11.6 and 6.9 ( 99 Tc m -PnAO-nitroimidazole), and 5.7 and 6.2 ( 99 Tc m -HL91), respectively. The lung to heart ratios at 60 min of 99 Tc m -PnAO-nitroimidazole and 99 Tc m -HL91 were 1.8 and 2.1, respectively 2) The accumulation of 99 Tc m -PnAo-nitroimidazole in the hypoxic, low perfusion and ischemic hearts was 4.8, 3.7 and 2.8 times that in the control hearts. At 60 min after starting washout, the retentions of 99 Tc m -PnAO-nitroimidazole in hypoxic, low flow and ischemic reperfusion myocardium were much higher than that of control hearts [(23.7 +- 9.1)%]. The accumulation of 99 Tc m -HL91 in the hypoxic and low perfusion hearts was also significantly higher than that in the control and ischemic reperfusion hearts, P 99 Tc m -HL91 in the low perfusion heart was 5.34, 3.43 and 1.23 times those of control, ischemic reperfusion and hypoxic hearts, respectively. Conclusions: 99 Tc m -PnAO-nitroimidazole can be accumulated in low perfusion, ischemic reperfusion and hypoxic hearts, while 99 Tc m -HL91 is mainly accumulated in hypoxic, specially low perfusion hearts. Since there is a high L/H in perfusions with either agent, the detecting of inferoposterior wall may be

An experimental study of 99Tcm-HL91 in detection of myocardial viability

International Nuclear Information System (INIS)

Xu Tao; Liu Baoping; Meng Yubao; Sun Bingqi; Niu Guangjun; Han Xingmin; Yuan Qiao

2005-01-01

Objective: To investigate whether 99 Tc m -4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime (HL91) can be used to distinguish ischemic myocardium segments from infarction segments. Methods: Twenty-five acute myocardial infarction patients (≤6 weeks) and 5 old myocardial infarction patients (> 6 weeks) were included in the study. All the study patients underwent 99 Tc m -HL91 and 99 Tc m -methoxyisobutylisonitrile (MIBI) imaging intervented and unintervented with nitroglycerin, and the myocardium segments were divided into three groups according to 99 Tc m -MIBI imaging results: normal, ischemic, and infarction myocardium segments. The difference of the radial counts of 99 Tc m -HL91 in three groups were analyzed after the imaging with 99 Tc m -HL91. Results: 1) In acute myocardial infarction patients, the accumulation rates of 99 Tc m -HL91 was 95% in normal segment group, 157% in ischemic group, 93% in infarction group. The accumulation rates of 99 Tc m -HL91 in the ischemic group was higher than that in the normal group and infarction group. 2)In old myocardial infarction patients, the accumulation rates of 99 Tc m -HL91 were of no difference among the normal, ischemic, and infarction groups. Conclusion: 99 Tc m -HL91 is a potential marker for detecting the ischemic myocardial tissue. (authors)

H/L transition time estimation in JET using conformal predictors

Energy Technology Data Exchange (ETDEWEB)

Gonzalez, S., E-mail: sergio.gonzalez@ciemat.es [Asociacion EURATOM/CIEMAT para Fusion, Madrid 28040 (Spain); Vega, J. [Asociacion EURATOM/CIEMAT para Fusion, Madrid 28040 (Spain); Murari, A. [Consorzio RFX, Associazione EURATOM/ENEA per la Fusione, Padova 4-25127 (Italy); Pereira, A. [Asociacion EURATOM/CIEMAT para Fusion, Madrid 28040 (Spain); Dormido-Canto, S.; Ramirez, J.M. [Departamento de Informatica y Automatica, UNED, Madrid 28040 (Spain)

2012-12-15

Highlights: Black-Right-Pointing-Pointer H/L transitions have been predicted using H/L and L/H models. Black-Right-Pointing-Pointer Models have been built using conformal predictors to hedge the prediction with confidence and credibility measures. Black-Right-Pointing-Pointer Models have been trained using linear and radial basis function kernels. Black-Right-Pointing-Pointer Conformal measures have proven their usefulness to validate data-driven models. - Abstract: Recent advances in data mining allow the automatic recognition of physical phenomena in the databases of fusion devices without human intervention. This is important to create large databases of physical events (thereby increasing the statistical relevance) in an unattended manner. Important examples are the L/H and H/L transitions. In this contribution, a novel technique is introduced to automatically locate H/L transitions in JET by using conformal predictors. The focus is on H/L transitions because typically there is not a clear signature in the time series of the most widely available signals to recognize the change of confinement. Conformal predictors hedge their prediction by means of two parameters: confidence and credibility. The technique has been based on binary supervised classifiers to separate the samples of the respective confinement modes. Results with several underlying classifiers are presented.

Bayesian soft x-ray tomography and MHD mode analysis on HL-2A

Science.gov (United States)

Li, Dong; Liu, Yi; Svensson, J.; Liu, Y. Q.; Song, X. M.; Yu, L. M.; Mao, Rui; Fu, B. Z.; Deng, Wei; Yuan, B. S.; Ji, X. Q.; Xu, Yuan; Chen, Wei; Zhou, Yan; Yang, Q. W.; Duan, X. R.; Liu, Yong; HL-2A Team

2016-03-01

A Bayesian based tomography method using so-called Gaussian processes (GPs) for the emission model has been applied to the soft x-ray (SXR) diagnostics on HL-2A tokamak. To improve the accuracy of reconstructions, the standard GP is extended to a non-stationary version so that different smoothness between the plasma center and the edge can be taken into account in the algorithm. The uncertainty in the reconstruction arising from measurement errors and incapability can be fully analyzed by the usage of Bayesian probability theory. In this work, the SXR reconstructions by this non-stationary Gaussian processes tomography (NSGPT) method have been compared with the equilibrium magnetic flux surfaces, generally achieving a satisfactory agreement in terms of both shape and position. In addition, singular-value-decomposition (SVD) and Fast Fourier Transform (FFT) techniques have been applied for the analysis of SXR and magnetic diagnostics, in order to explore the spatial and temporal features of the saturated long-lived magnetohydrodynamics (MHD) instability induced by energetic particles during neutral beam injection (NBI) on HL-2A. The result shows that this ideal internal kink instability has a dominant m/n  =  1/1 mode structure along with a harmonics m/n  =  2/2, which are coupled near the q  =  1 surface with a rotation frequency of 12 kHz.

Adèle, version abâtardie de Jane Eyre Adèle, an “Addled” Version of Jane Eyre?

Directory of Open Access Journals (Sweden)

Claire Bazin

2009-10-01

Full Text Available Adèle is a rewriting of the story of Jane Eyre published 150 years before. Emma Tennant, who is a specialist in the field of « revisions » puts Adèle, Jane’s young pupil in the Ur-text, in the limelight by giving her a « story  of her own », as if she were taking her revenge on the original text which had given her so insignificant a part.

Upgrade of the ATLAS Muon Barrel Trigger for HL-LHC

CERN Document Server

Romano, Marino; The ATLAS collaboration

2015-01-01

The present ATLAS muon trigger in the barrel region (|eta|<1.05) is based on three layers of RPC chambers. It was designed to run for 10 years at the LHC luminosity of 10^{34} cm^{-2}s^{-1} and operated successfully and with high selectivity during the first run of the LHC. In order to ensure a stable performance of the RPCs until 2035 at the higher rates and at luminosities of 5-7x10^{34} cm^{-2}s^{-1} provided by HL-LHC, the chambers will have to be operated with reduced gas gain to respect the original design limits on currents and integrated charge. The ATLAS muon collaboration proposes an upgrade of the system by installing an inner layer of new generation RPCs during the LHC shutdown expected for the year 2023. This new layer will increase the system redundancy and therefore allow operation with high efficiency and high selectivity during the HL-LHC phase. The insertion of this new layer will also increase the geometrical acceptance in the barrel region from 75% to 95%. Moreover, the additional measu...

Upgrade of the ATLAS Muon Barrel Trigger for HL-LHC.

CERN Document Server

Biondi, Silvia; The ATLAS collaboration

2015-01-01

The present ATLAS muon trigger in the barrel region (|η | < 1.05) is based on three layers of RPC chambers. It was designed to run for 10 years at the LHC luminosity of 1034cm−2s−1 and operated successfully and with high selectivity during the first run of the LHC. In order to ensure a stable performance of the RPCs until 2035 at the higher rates and at luminosities of 5−7x1034cm−2s−1 provided by HL-LHC, the chambers will have to be operated with reduced gas gain to respect the original design limits on currents and integrated charge. The ATLAS muon collaboration proposes an upgrade of the system by installing an inner layer of new generation RPCs during the LHC shutdown expected for the year 2023. This new layer will increase the system redundancy and therefore allow operation with high efficiency and high selectivity during the HL-LHC phase. The insertion of this new layer will also increase the geometrical acceptance in the barrel region from 75% to 95%. Moreover, the additional measurements ...

Breaching the Phase I Optics Limitations for the HL-LHC

CERN Document Server

Fartoukh, S

2011-01-01

This paper scrutinizes the performance goal of the HL-LHC Project and proposes a solution to reach it. This solution is based on an Achromatic Telescopic Squeezing (ATS) principle which can push beta* well below the limits which were identified in the context of the so-called Phase I Upgrade studies. The novel optics scheme is described, with its main weak points, possible mitigation measures and hardware modifications needed in the LHC ring in order to implement it. Other implications or by-products are also highlighted. Some of them are rather exotic and are worth to be mentioned in the abstract even if not completely developed in the paper: the possibility to run with a third low-beta experiment installed in IR3 or IR7 (which is an interesting direction for a smooth co-habitation between the HL-LHC and the LHeC), a notable reduction of the IBS growth rate in the longitudinal plane (generally the most critical plane), or a boost by more than one order of magnitude for the efficiency of the Landau octupoles,...

Breaching the Phase I optics limitations for the HL-LHC

CERN Document Server

Fartoukh, S

2011-01-01

This paper scrutinizes the performance goal of the HL-LHC Project and proposes a solution to reach it. This solution is based on an Achromatic Telescopic Squeezing (ATS) principle which can push β ∗ well below the limits which were identified in the context of the so-called Phase I Upgrade studies. The novel optics scheme is described, with its main weak points, possible mitigation measures and hardware modifications needed in the LHC ring in order to implement it. Other implications or by-products are also highlighted. Some of them are rather exotic and are worth to be mentioned in the abstract even if not completely developed in the paper: the possibility to run with a third low-β experiment installed in IR3 or IR7 (which is an interesting direction for a smooth co-habitation between the HL-LHC and the LHeC), a notable reduction of the IBS growth rate in the longitudinal plane (generally the most critical plane), or a boost by more than one order of magnitude for the efficiency of the Landau octupoles, ...

Upgrade Plans for ATLAS Forward Calorimetry for the HL-LHC

CERN Document Server

Krieger, P; The ATLAS collaboration

2013-01-01

The upgrade of the LHC Collider foresees increased instantaneous luminosity 3-7 times the original design value of 10$^{34}$ cm$^{-2}$ s$^{-1}$. The increased particle flux at this high luminosity phase of the LHC (HL-LHC) will have an impact on many sub-systems of the ATLAS detector. In particular, in the LAr forward calorimeter (FCal), which was designed for operation at LHC luminosities, the associated increase in the ionization load at HL-LHC luminosities poses a number of problems that can degrade its performance, related to beam heating, space charge effects in the LAr gaps and HV drop due to increased current draws over the HV current-limiting resistors. One solution to these problems, which would require the opening of both ATLAS endcap cryostats, is the construction and installation of a new FCal, with cooling loops, narrower LAr gaps, and lower value protection resistors. The signal performance of the current FCal and of a possible narrow-gap FCal has been measured in a dedicated test-beam campaign ...

Preliminary applied study of assessment ischemic/viable myocardium by 99Tcm-HL91

International Nuclear Information System (INIS)

Liu Gang; Wu Hua

2004-01-01

Objective: To investigate the representation of 99 Tc m -HL91 in the ischemic myocardium, evaluate the diagnosis value of 99 Tc m -HL91 on hypoxic but viable myocardium. Methods: Six patients with cardiac infarction all underwent 99 Tc m -MIBI SPECT and 99 Tc m -HL91 SPECT. Average radioactivity of ischemic area and normal area were respectively obtained by ROI (2 x 2 pixels) on heart minor axis of images, And the radioactivity ratios of target (ischemic area)-to-non target(normal area)were calculated. Results: In image of 99 Tc m -HL91 SPECT, two patients who's radioactivity coloboma of 99 Tc m -MIBI image could be filled with 99 Tc m -HL91, four patients were not caught sight of obvious filling up. Conclusion 99 Tc m -HL91 can be selectively uptaken by ischemic and hypoxic but viable myocardium. it combination of 99 Tc m -MIBI SPECT may be good for accurate diagnosis and differentiation of viable myocardium. (authors)

Melinda - A custom search engine that provides access to locally-developed content using the HL7 Infobutton standard.

Science.gov (United States)

Wan, Yik-Ki J; Staes, Catherine J

2016-01-01

Healthcare organizations use care pathways to standardize care, but once developed, adoption rates often remain low. One challenge for usage concerns clinicians' difficulty in accessing guidance when it is most needed. Although the HL7 'Infobutton Standard' allows clinicians easier access to external references, access to locally-developed resources often requires clinicians to deviate from their normal electronic health record (EHR) workflow to use another application. To address this gap between internal and external resources, we reviewed the literature and existing practices at the University of Utah Health Care. We identify the requirements to meet the needs of a healthcare enterprise and clinicians, describe the design and development of a prototype to aggregate both internal and external resources from within or outside the EHR, and evaluated strengths and limitations of the prototype. The system is functional but not implemented in a live EHR environment. We suggest next steps and enhancements.

Tracking in Dense Environments for the HL-LHC ATLAS Detector

CERN Document Server

Cormier, Felix; The ATLAS collaboration

2018-01-01

Tracking in dense environments, such as in the cores of high-energy jets, will be key for new physics searches as well as measurements of the Standard Model at the High Luminosity LHC (HL-LHC). The HL-LHC will operate in challenging conditions with large radiation doses and high pile-up (up to $\\mu=200$). The current tracking detector will be replaced with a new all-silicon Inner Tracker for the Phase II upgrade of the ATLAS detector. In this talk, characterization of the HL-LHC tracker performance for collimated, high-density charged particles arising from high-momentum decays is presented. In such decays the charged-particle separations are of the order of the tracking detector granularity, leading to challenging reconstruction. The ability of the HL-LHC ATLAS tracker to reconstruct the tracks in such dense environments is discussed and compared to ATLAS Run-2 performance for a variety of relevant physics processes.

LLNL Yucca Mountain project - near-field environment characterization technical area: Letter report: EQ3/6 version 8: differences from version 7

Energy Technology Data Exchange (ETDEWEB)

Wolery, T.J.

1994-09-29

EQ3/6 is a software package for geochemical modeling of aqueous systems, such as water/rock or waste/water rock. It is being developed for a variety of applications in geochemical studies for the Yucca Mountain Site Characterization Project. The software has been extensively rewritten for Version 8. The source code has been extensively modernized. The software is now written in Fortran 77 with the most common extensions that are part of the new Fortran 90 standard. The architecture of the software has been improved for better performance and to allow the incorporation of new functional capabilities in Version 8 and planned subsequent versions. In particular, the structure of the major data arrays has been significantly altered and extended. Three new major functional capabilities have been incorporated in Version 8. The first of these allows the treatment of redox disequilibrium in reaction-path modeling. This is a natural extension of the long-running capability of providing for such disequilibrium in static speciation-solubility calculations. Such a capability is important, for example, when dealing with systems containing organic species and certain dissolved gas species. The user defines (and sets the controls for) the components in disequilibrium. Such corrections can now be made if the requisite data are present on a supporting data file. At present, this capability is supported only by the SHV data file, which is based on SUPCRT92. Equilibrium constants and other thermodynamic quantities are correct1961ed for pressures which lie off a standard curve, which is defined on the supporting data file and ordinarily corresponds to 1.013 bar up to IOOC, and the steam/liquid water equilibrium pressure up to 300C. The third new major capability is generic ion exchange option previously developed in prototype in a branch Version 7 level version of EQ3/6 by Brian Viani, Bill Bourcier, and Carol Bruton. This option has been modified to fit into the Version 8 data

Confinement, glueballs and strings from deformed AdS

International Nuclear Information System (INIS)

Apreda, Riccardo; Crooks, David E.; Evans, Nick; Petrini, Michela

2004-01-01

We study aspects of confinement in two deformed versions of the AdS/CFT correspondence - the GPPZ dual of N = 1* Yang Mills, and the Yang Mills* N 0 dual. Both geometries describe discrete glueball spectra which we calculate numerically. The results agree at the 10% level with previous AdS/CFT computations in the Klebanov Strassler background and AdS Schwarzchild respectively. We also calculate the spectra of bound states of the massive fermions in these geometries and show that they are light, so not decoupled from the dynamics. We then study the behaviour of Wilson loops in the 10d lifts of these geometries. We find a transition from AdS-like strings in the UV to strings that interact with the unknown physics of the central singularity of the space in the IR. (author)

Visual Sample Plan Version 7.0 User's Guide

Energy Technology Data Exchange (ETDEWEB)

Matzke, Brett D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Newburn, Lisa LN [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hathaway, John E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bramer, Lisa M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wilson, John E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dowson, Scott T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sego, Landon H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Pulsipher, Brent A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2014-03-01

User's guide for VSP 7.0 This user's guide describes Visual Sample Plan (VSP) Version 7.0 and provides instructions for using the software. VSP selects the appropriate number and location of environmental samples to ensure that the results of statistical tests performed to provide input to risk decisions have the required confidence and performance. VSP Version 7.0 provides sample-size equations or algorithms needed by specific statistical tests appropriate for specific environmental sampling objectives. It also provides data quality assessment and statistical analysis functions to support evaluation of the data and determine whether the data support decisions regarding sites suspected of contamination. The easy-to-use program is highly visual and graphic. VSP runs on personal computers with Microsoft Windows operating systems (XP, Vista, Windows 7, and Windows 8). Designed primarily for project managers and users without expertise in statistics, VSP is applicable to two- and three-dimensional populations to be sampled (e.g., rooms and buildings, surface soil, a defined layer of subsurface soil, water bodies, and other similar applications) for studies of environmental quality. VSP is also applicable for designing sampling plans for assessing chem/rad/bio threat and hazard identification within rooms and buildings, and for designing geophysical surveys for unexploded ordnance (UXO) identification.

Instantons on D7 brane probes and AdS/CFT with flavour

International Nuclear Information System (INIS)

Apreda, R.; Erdmenger, J.; Grosse, J.; Evans, N.; Guralnik, Z.

2006-01-01

Recent work on adding flavour to the generalized AdS/CFT correspondence is reviewed. In particular, we consider instanton configurations on two coincident D7 brane probes. These are matched to the Higgs branch of the dual field theory. In AdS 5 x S 5 , the instanton generates a flow of the meson spectrum. For non-supersymmetric gravity backgrounds, the Higgs branch is lifted by a potential with non-trivial physical implications. (Abstract Copyright [2006], Wiley Periodicals, Inc.)

Synthesis and Biological Activity of Diastereomeric and Geometric Analogs of Calcipotriol, PRI-2202 and PRI-2205, Against Human HL-60 Leukemia and MCF-7 Breast Cancer Cells

Directory of Open Access Journals (Sweden)

Andrzej Kutner

2013-10-01

Full Text Available Diastereomeric and geometric analogs of calcipotriol, PRI-2202 and PRI-2205, were synthesized as advanced intermediates from vitamin D C-22 benzothiazoyl sulfones and side-chain aldehydes using our convergent strategy. Calcitriol, calcipotriol (PRI-2201 and tacalcitol (PRI-2191 were used as the reference compounds. Among a series of tested analogs the diastereomeric analog PRI-2202 showed the strongest antiproliferative activity on the human breast cancer cell line MCF-7, whereas the geometric analog PRI-2205 was the weakest. Both analogs were less potent in antiproliferative activity against HL-60 cells compared to the reference compounds. The ability to potentiate antiproliferative effect of cisplatin or doxorubicin against HL-60 cells or that of tamoxifen against the MCF-7 cell line was observed at higher doses of PRI-2202 or PRI-2205 than those of the reference compounds. The proapoptotic activity of tamoxifen, expressed as the diminished mitochondrial membrane potential, as well as the increased phosphatidylserine expression, was partially attenuated by calcitriol, PRI-2191, PRI-2201 and PRI-2205. The treatment of the MCF-7 cells with tamoxifen alone resulted in an increase in VDR expression. Moreover, a further increase in VDR expression was observed when the analogs PRI-2201 or PRI-2205, but not PRI-2191, were used in combination with tamoxifen. This observation could partially explain the potentiation of the antiproliferative effect of tamoxifen by vitamin D analogs.

Impact of mobility on the performance7 of relaying in ad hoc networks – Extended version

NARCIS (Netherlands)

Al Hanbali, Ahmad; Kherani, A.A.; Groenevelt, R.; Nain, P.; Altman, E

2007-01-01

We consider a mobile ad hoc network consisting of three types of nodes: source, destination, and relay nodes. All the nodes are moving over a bounded region with possibly different mobility patterns. We introduce and study the notion of relay throughput, i.e. the maximum rate at which a node can

Analysis of the process of representing clinical statements for decision-support applications: a comparison of openEHR archetypes and HL7 virtual medical record.

Science.gov (United States)

González-Ferrer, A; Peleg, M; Marcos, M; Maldonado, J A

2016-07-01

Delivering patient-specific decision-support based on computer-interpretable guidelines (CIGs) requires mapping CIG clinical statements (data items, clinical recommendations) into patients' data. This is most effectively done via intermediate data schemas, which enable querying the data according to the semantics of a shared standard intermediate schema. This study aims to evaluate the use of HL7 virtual medical record (vMR) and openEHR archetypes as intermediate schemas for capturing clinical statements from CIGs that are mappable to electronic health records (EHRs) containing patient data and patient-specific recommendations. Using qualitative research methods, we analyzed the encoding of ten representative clinical statements taken from two CIGs used in real decision-support systems into two health information models (openEHR archetypes and HL7 vMR instances) by four experienced informaticians. Discussion among the modelers about each case study example greatly increased our understanding of the capabilities of these standards, which we share in this educational paper. Differing in content and structure, the openEHR archetypes were found to contain a greater level of representational detail and structure while the vMR representations took fewer steps to complete. The use of openEHR in the encoding of CIG clinical statements could potentially facilitate applications other than decision-support, including intelligent data analysis and integration of additional properties of data items from existing EHRs. On the other hand, due to their smaller size and fewer details, the use of vMR potentially supports quicker mapping of EHR data into clinical statements.

HL60 human premyelocitic cell line as a model system for bystander response

International Nuclear Information System (INIS)

Dini, V.; Tabocchini, M.A.; Belli, M.; Simone, G.; Di Carlo, B.; Sapora, O.; Superiore di Sanita, Rome

2007-01-01

Complete text of publication follows. Objective: to evaluate HL60 human premyelocitic cell line as a model system to study bystander response. Methods: HL60 cell line, isolated from the blood of a patient affected by premyelocitic leukemia, has 45-46 chromosomes with abnormalities mainly on chromosomes 5, 8 and X and can undergo chemical-induced in vitro differentiation. Differentiation gives rise to granulocytes, monocytes or macrophages depending on the drug used. We define as proliferative (AP) cells those in log phase of growth with less than 10 passages from thawing and as differentiated (D) cells those treated with 10 nM TPA (phorbol ester) for 72 hours. Phorbol ester treatment induces differentiation to monocytes and macrophages. Differentiation has been evaluated through the expression of differentiation cluster membrane antigens (CD95, CD9 and CD14). Results: AP cells resulted positive for CD95 and negative for CD9 and CD14, while D cells resulted positive for CD9 and negative for CD95 and CD14. Our data on AP and D cells showed that: (i) the level of intracellular reactive oxygen and nitrogen species (ROS and RNS) is lower in D cells compared to AP cells; (ii) radiation induced DNA damage (single and double strand breaks, SSB and DSB, as measured with the comet assay technique) is lower in D cells than in AP cells. This different radiosensitivity can be related to the higher degree of compactness of nuclear structure in D cells. Radiation induced bystander effect (BE) was analyzed with the medium transfer technique. The medium from irradiated, with 0.5 Gy of γ-rays, AP cells was collected after 0, 2, 4 and 24 hours from irradiation and added to non irradiated log phase cells. The frequency of micronuclei formation in bystander cells was measured by using the cytokinesis block technique by adding cytochalasin B to the non irradiated culture together with the irradiated medium. Preliminary data indicate about 1.4-fold increase in micronuclei formation in

The preparation and biological characterization of a new HL91-derivative for hypoxic imaging on stroke mice

Energy Technology Data Exchange (ETDEWEB)

Hsia, C.-C. [Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taiwan (China); Institute of Nuclear Energy Research, Taiwan (China); Huang, F.-L.; Lin, C.-H.; Shen, L.-H. [Institute of Nuclear Energy Research, Taiwan (China); Wang, H.-E., E-mail: hewang@ym.edu.t [Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taiwan (China)

2010-09-15

Aim: {sup 99m}Tc-HL91 (Prognox, GE-Healthcare) was the first nonnitro-aryl-based radiotracer for evaluating hypoxic fraction in neoplasm, stroke and myocardium infarction regions. However, the high hydrophilicity of {sup 99m}Tc-HL91 might hamper its penetration into cells. In this study, we prepared a new ligand 4,4,11,11-tetramethyl- 5,10-diazatetradecane- 3,12-dionedioxime (HL91-ET) with higher lipophilicity but structurally similar compared with that of HL91. The chemical and biological characterizations of {sup 99m}Tc-HL91-ET as a scintigraphic probe for hypoxia were performed with a stroke-bearing mouse model. Materials and Methods: HL91-ET was synthesized and formulated with stannous chloride and buffer to afford kits. After mixing with {sup 99m}Tc-pertechnetate, {sup 99m}Tc-HL91-ET can be prepared in high yield and high radiochemical purity (both >96%). The partition coefficient of {sup 99m}Tc-HL91-ET was determined in n-octanol/PBS system. Cellular uptake assays under normoxic and hypoxic conditions were performed in an oxygen-controlled CO{sub 2} incubator. Brain stroke in the mouse model was induced by the electrocautery of the middle cerebral artery. After intravenous injection of {sup 99m}Tc-HL91-ET into the Balb/c mouse suffering brain stroke, small-animal SPECT images were acquired at designated time points and autoradiography of the brain slides was conducted. Parallel studies of {sup 99m}Tc-HL91 were also conducted at the same conditions for comparison. Results: The higher partition coefficient of {sup 99m}Tc-HL91-ET (0.294{+-}0.007) indicated higher lipophlicity compared with that of {sup 99m}Tc-HL91 (0.089{+-}0.005). The {sup 99m}Tc-HL91-ET preparation was stable at ambient temperature for 24 h. Cellular uptake assay showed that {sup 99m}Tc-HL91-ET was less selectively retained in hypoxic cells than {sup 99m}Tc-HL91. The target-to-normal brain ratios derived from the autoradiograms of the brains of stroke mice were 1.31{+-}0.02 and 17

The preparation and biological characterization of a new HL91-derivative for hypoxic imaging on stroke mice

International Nuclear Information System (INIS)

Hsia, C.-C.; Huang, F.-L.; Lin, C.-H.; Shen, L.-H.; Wang, H.-E.

2010-01-01

Aim: 99m Tc-HL91 (Prognox, GE-Healthcare) was the first nonnitro-aryl-based radiotracer for evaluating hypoxic fraction in neoplasm, stroke and myocardium infarction regions. However, the high hydrophilicity of 99m Tc-HL91 might hamper its penetration into cells. In this study, we prepared a new ligand 4,4,11,11-tetramethyl- 5,10-diazatetradecane- 3,12-dionedioxime (HL91-ET) with higher lipophilicity but structurally similar compared with that of HL91. The chemical and biological characterizations of 99m Tc-HL91-ET as a scintigraphic probe for hypoxia were performed with a stroke-bearing mouse model. Materials and Methods: HL91-ET was synthesized and formulated with stannous chloride and buffer to afford kits. After mixing with 99m Tc-pertechnetate, 99m Tc-HL91-ET can be prepared in high yield and high radiochemical purity (both >96%). The partition coefficient of 99m Tc-HL91-ET was determined in n-octanol/PBS system. Cellular uptake assays under normoxic and hypoxic conditions were performed in an oxygen-controlled CO 2 incubator. Brain stroke in the mouse model was induced by the electrocautery of the middle cerebral artery. After intravenous injection of 99m Tc-HL91-ET into the Balb/c mouse suffering brain stroke, small-animal SPECT images were acquired at designated time points and autoradiography of the brain slides was conducted. Parallel studies of 99m Tc-HL91 were also conducted at the same conditions for comparison. Results: The higher partition coefficient of 99m Tc-HL91-ET (0.294±0.007) indicated higher lipophlicity compared with that of 99m Tc-HL91 (0.089±0.005). The 99m Tc-HL91-ET preparation was stable at ambient temperature for 24 h. Cellular uptake assay showed that 99m Tc-HL91-ET was less selectively retained in hypoxic cells than 99m Tc-HL91. The target-to-normal brain ratios derived from the autoradiograms of the brains of stroke mice were 1.31±0.02 and 17.47±0.10 (n=3), respectively, at 2 h post injection of 99m Tc-HL91-ET and 99m Tc-HL91

A new way of soft X-ray spectrum measurement in the HL-2A tokamak

International Nuclear Information System (INIS)

Liao Min; Chen Liaoyuan; Song Xianying; Li Yongge; Luo Cuiwen; Pan Wei; Pan Li

2007-01-01

A soft X-ray spectrum measurement system is newly developed for the real-time acquisition, data processing and display of electron temperature. In this system, a personal computer with high-speed A/D acquisition card is used to obtain the original analog data and processing software is specially developed to calculate the electron temperature. Compared with PHA (Pulse Height Analyzer), the new system provides a way to set channel number and time solution by software. This method has been applied in the HL-2A tokamak experiment, and the result shows a good agreement with the electron temperature tested by other measurements. (authors)

Preliminary clinical study of 99Tcm-HL91 imaging in bone metastasis

International Nuclear Information System (INIS)

Liu Baoping; Mao Ronghu; Han Xingmin

2008-01-01

Objective: 99 Tc m -4, 9-diaza-3, 3, 10, 10-tetramethyldodecan-2, 11-dione dioxime (HL91), a new type of hypoxic agents, accumulates in tumor hypoxic tissue specifically. The aim of this study was to evaluate the value of 99 Tc m -HL91 imaging in the diagnosis of bone metastasis. Methods: Nine- teen cases with bone metastasis (without any treatment) and 8 cases with benign lesions underwent SPECT imaging at 4 h after injection of 740 MBq of 99 Tc m -HL91 along with 99 Tc m -methylene diphosphonic acid (MDP) imaging. Regions of interest (ROIs) were drawn in tumor tissue and contralateral normal tissue respectively, and the radioactivity ratios of tumor-to-normal (T/N) were calculated. The t-test was used for data analysis with SPSS 11.0. Results: There were visible uptake of 99 Tc m -HL91 in 79 out of 85 focuses in 19 patients of bone metastasis; however, there was no obvious uptake of 99 Tc m -HL91 in 12 focuses of 8 patients of benign lesions. Significant difference existed between the T/N values of malignant (1.877 ± 0.288) and benign lesions [(0.735 ± 0.236); t=13.065, P 0.05). Conclusion: The results indicated that 99 Tc m -HL91 was useful in diagnosing the malignant and benign bone lesions. (authors)

Design of Pulse Oximeter with WiFi Connectivity and Interoperability with Standard HL7 and IEEE 11073-10404:2008

Directory of Open Access Journals (Sweden)

Víctor Ochoa

2014-12-01

Full Text Available Given that health is so relevant for global productivity and competitiveness, and that the Information and Communications Technology (ICTs play an important role in all of the productivity factors, this work makes use of the ICTs in health matters proposing the to use a WiFi oximeter. This article describes the operating principles of a Pulse Oximeter (PO which is an opto-electronic non-invasive medical instrument capable of measuring changes in heart rate (HR and SpO2 at the fingertip and its upgrade to the standards; HL7 and IEEE 11073-10404:2008, its design, and its validation against the three existing devices. Variables (SpO2%, Ppm and Temperature were compared, and its performance and impact were discussed the addition of the WiFi technology allows a better communication between devices, causing a greater impact in global competiveness.

Pixel DAQ and trigger for HL-LHC

International Nuclear Information System (INIS)

Morettini, P.

2017-01-01

The read-out is one of the challenges in the design of a pixel detector for the High Luminosity upgrade of the Large Hadron Collider (HL-LHC), that is expected to operate from 2026 at a leveled luminosity of 5 × 10 34  cm −2  s −1 . This is especially true if tracking information is needed in a low latency trigger system. The difficulties of a fast read-out will be reviewed, and possible strategies explained. The solutions that are being evaluated by the ATLAS and CMS collaborations for the upgrade of their trackers will be outlined and ideas on possible development beyond HL-LHC will be presented.

Effects of fuelling by using high-pressure supersonic molecular beam in the HL-1M tokamak

International Nuclear Information System (INIS)

Yao Lianghua; Feng Beibin; Feng Zhen; Dong Jiafu; Li Wenzhong; Xu Deming; Hong Wenyu

2002-01-01

Supersonic molecular beam (SMB), as a new fuelling method, has been successfully developed and used in HL-1M tokamak and HT-7 superconducting tokamak. The hydrogen clusters have been found in the beam produced by high working-gas pressure in recent experiments. With a penetration depth of hydrogen particles greater than 17 cm, the rate of increase of electron density for SMB injection, dn e -bar/dt, approaches that of the small ice pellet injection. The plasma density increases step by step after multi-pulse SMB injection, just as multi-pellet fuelling. Comparison of fuelling effects was made between SMB and ice pellet injection on the same shot of ohmic discharge in HL-1M

HL-LHC alternatives

CERN Document Server

Tomás, R; White, S

2014-01-01

The HL-LHC parameters assume unexplored regimes for hadron colliders in various aspects of accelerator beam dynamics and technology. This paper reviews three alternatives that could potentially improve the LHC performance: (i) the alternative filling scheme 8b+4e, (ii) the use of a 200 MHz RF system in the LHC and (iii) the use of proton cooling methods to reduce the beam emittance (at top energy and at injection). The alternatives are assessed in terms of feasibility, pros and cons, risks versus benefits and the impact on beam availability.

The HL-LHC accelerator physics challenges

CERN Document Server

Fartoukh, S

2014-01-01

We review the conceptual baseline of the HL-LHC project, putting into perspective the main beam physics challenges of this new collider in comparison with the existing LHC, and the series of solutions and possible mitigation measures presently envisaged.

The HL-LHC Accelerator Physics Challenges

Science.gov (United States)

Fartoukh, S.; Zimmermann, F.

The conceptual baseline of the HL-LHC project is reviewed, putting into perspective the main beam physics challenges of this new collider in comparison with the existing LHC, and the series of solutions and possible mitigation measures presently envisaged.

The HL-LHC accelerator physics challenges

CERN Document Server

Fartoukh, S

2015-01-01

The conceptual baseline of the HL-LHC project is reviewed, putting into perspective the main beam physics challenges of this new collider in comparison with the existing LHC, and the series of solutions and possible mitigation measures presently envisaged.

Isolation of furocoumarins from bergamot fruits as HL-60 differentiation-inducing compounds.

Science.gov (United States)

Kawaii, S; Tomono, Y; Katase, E; Ogawa, K; Yano, M

1999-10-01

The HL-60 differentiation-inducing compounds in bergamot fruits were isolated with column chromatography and identified as bergamottin, bergapten, and citropten by (1)H and (13)C NMR. Their HL-60 differentiation-inducing activity was measured by examining nitro blue tetrazolium (NBT) reducing, nonspecific acid esterase (NSE), specific esterase (SE), and phagocytic activities, and bergamottin showed the strongest activity among the coumarins isolated from bergamot fruits. The structure-activity relationship obtained from HL-60 differentiation assay suggests that hydrophobicity of furocoumarins is correlated with their activity.

HL-LHC kicker magnet (MKI)

CERN Multimedia

Brice, Maximilien

2018-01-01

HL-LHC kicker magnet (MKI): last vacuum test, preparation for transport to LHC transfer line in underground tunnel.The LHC injection kicker systems (MKIs) generate fast field pulses to inject the clockwise rotating beam at Point 2 and the anti-clockwise rotating beam at Point 8: there are eight MKI magnets installed in total. Each MKI magnet contains a high purity alumina tube: if an MKI magnet is replaced this tube requires conditioning with LHC beam: until it is properly conditioned, there can be high vacuum pressure due to the beam. This high pressure can also cause electrical breakdowns in the MKI magnets. A special coating (Cr2O3) has been applied to the inside of the alumina tube of an upgraded MKI magnet – this is expected to greatly reduce the pressure rise with beam. In addition, HL-LHC beam would result in excessive heating of the MKI magnets: the upgraded design includes modifications that will reduce heating, and move the power deposition to parts that will be easier to cool. Experience during 2...

Non-relativistic AdS branes and Newton-Hooke superalgebra

International Nuclear Information System (INIS)

Sakaguchi, Makoto; Yoshida, Kentaroh

2006-01-01

We examine a non-relativistic limit of D-branes in AdS 5 x S 5 and M-branes in AdS 4/7 x S 7/4 . First, Newton-Hooke superalgebras for the AdS branes are derived from AdS x S superalgebras as Inoenue-Wigner contractions. It is shown that the directions along which the AdS-brane worldvolume extends are restricted by requiring that the isometry on the AdS-brane worldvolume and the Lorentz symmetry in the transverse space naturally extend to the super-isometry. We also derive Newton-Hooke superalgebras for pp-wave branes and show that the directions along which a brane worldvolume extends are restricted. Then the Wess-Zumino terms of the AdS branes are derived by using the Chevalley-Eilenberg cohomology on the super-AdS x S algebra, and the non-relativistic limit of the AdS-brane actions is considered. We show that the consistent limit is possible for the following branes: Dp (even,even) for p = 1 mod 4 and Dp (odd,odd) for p = 3 mod 4 in AdS 5 x S 5 , and M2 (0,3), M2 (2,1), M5 (1,5) and M5 (3,3) in AdS 4 x S 7 and S 4 x AdS 7 . We furthermore present non-relativistic actions for the AdS branes

CBC3: a CMS microstrip readout ASIC with logic for track-trigger modules at HL-LHC

CERN Document Server

Prydderch, Mark Lyndon; Bell, Stephen Jean-marc; Key-Charriere, M; Jones, Lawrence; Auzinger, Georg; Borg, Johan; Hall, Geoffrey; Pesaresi, Mark Franco; Raymond, David Mark; Uchida, Kirika; Goldstein, Joel; Seif El Nasr, Sarah

2018-01-01

The CBC3 is the latest version of the CMS Binary Chip ASIC for readout of the outer radial region of the upgraded CMS Tracker at HL-LHC. This 254-channel, 130nm CMOS ASIC is designed to be bump-bonded to a substrate to which sensors will be wire-bonded. It will instrument double-layer 2S-modules, consisting of two overlaid silicon microstrip sensors with aligned microstrips. On-chip logic identifies first level trigger primitives from high transverse-momentum tracks by selecting correlated hits in the two sensors. Delivered in late 2016, the CBC3 has been under test for several months, including X-ray irradiations and SEU testing. Results and performance are reported.

An experimental study on cerebral ischemic penumbra imaging with 99Tcm-HL91

International Nuclear Information System (INIS)

Zhu Cansheng; Jiang Ningyi

2002-01-01

Objective: To investigate the biodistribution of 99 Tc m -4,9-diaza-3,3,10,10-tetramethyl dodecan-2,11-dione dioxime (HL91) in rat model of middle cerebral artery occlusion (MCAO). Methods: Thirty-one MCAO rats were established. Fourteen rats were used to study the biodistribution of 99 Tc m -HL91 and 15 rats were used to study the distribution of 99 Tc m -HL91 in the brain of MCAO model rats. Autoradiographic study of brain was also done in 16 MCAO model rats. Results: The liver and kidney retention were higher than that in other tissues. At 1 h after injection, small intestine retention was also high. But radioactivity in normal brain was low. Retention in target site was higher than that in non-target site. Difference between subgroups of operation and that of pseudo operation was significant (P 99 Tc m -HL91 at the target-ischemic area was shown in the autoradiograph. By using computer-enhanced image analysis, difference between target site and non-target site in the same autoradiograph and the differences between operation subgroups and that of pseudo-subgroups were all significant via Dunnett t-test and One-Way ANOVA. Conclusions: 99 Tc m -HL91 can be avidly taken up by ischemic penumbra and target/non-target ratio is high. 99 Tc m -HL91 is a potential agent for hypoxic tissue imaging, and 99 Tc m -HL91 SPECT is a promising modality in detecting the ischemic penumbra

Application of 99Tcm-HL-91 in the hypoxia study of malignant lymphoma

International Nuclear Information System (INIS)

Li Li; Han Peizhen; Yan Yujun; Wang Yueying; Wang Junqi; Li Meijia

2002-01-01

Objective: 99 Tc m -HL91 is a putative hypoxic tracer probing hypoxia in solid tumors. This study was aimed at investigating the property of the spontaneous IRM-2-ML malignant lymphoma in homozygotic IRM-2 mice, and at testing the applicability of 99 Tc m -HL91 to the imaging of hypoxia in tumors. Methods: Biodistribution of 99 Tc m -HL91 after intravenously injection into normal and tumor-bearing IRM-2 mice was studied by determining blood and tissue levels of radioactivity from 20 to 360 min after injection. Nicotinamide was used to reduce the extent of hypoxia in the tumors. Planar SPECT imaging on normal and tumor-bearing IRM-2 mice was also performed. Results: Tumor load did not significantly influence the retention of 99 Tc m -HL91 in normal organs. 99 Tc m -HL91 was metabolized mainly via the liver and kidney, and was cleared fast from the blood. The tumor-to-blood ratio and tumor-to-muscle ratio continued to increase until 360 min (2.63 +- 0.25 and 3.37 +- 0.22 at 120 min, 3.51 +- 0.17 and 6.44 +- 0.29 at 360 min, respectively). The retention of 99 Tc m -HL91 in the tumor was reduced in mice by treatment with nicotinamide. Planar SPECT imaging showed that tumor could be observed clearly. Conclusion: These results confirm that IRM-2-ML malignant lymphoma possesses the common property of solid tumors,and also indicate that 99 Tc m -HL91 could be used to detect tumor hypoxia

Experimental study of hypoxia-imaging agent 99mTc-HL91 in mice bearing glioblastoma G422

International Nuclear Information System (INIS)

Zhou Ying; Qu Wanying; Yao Zhiming; Chen Fang; Zhu Ming; Zhu Lin

1999-01-01

Objective: To evaluate the ability of detecting cerebral tumor by 99m Tc-HL91 in mice bearing glioblastoma G422. Methods: Six model mice underwent static whole body planar imagings at once and at 1,2,3,4,6,7,8 h postinjection of 99m Tc-HL91. Three mice each were killed at 4 h and 8 h, respectively. the tumor, blood and organs were removed, weighted and the radioactivity was measured. ROIs were drawn around tumor, head, contralateral axilla and chest in whole body planar images, and the radioactivity ratios of tumor to head (T/H), contralateral axilla (T/A) and chest (T/C) were calculated. Results: Increased tumor activity was identified in static whole body planar images since 1 h postinjection. At 2h postinjection, T/H, T/A and T/C were 2.93 +- 0.51, 4.86 +- 0.79 and 2.00 +- 0.35 respectively, which were significantly higher than those at once and at 1h postinjection (P 99m Tc-HL91 in tumor tissue of mice bearing glioblastoma G422 is increased and clearance rate is decreased. 99m Tc-HL91 imaging is suitable for glioblastoma at 2 h postinjection. It is appropriate to image tumors in head, neck, thorax, bone and soft tissues, but not in abdominal area

1,25 dihydroxyvitamin D3 (1,25) regulation of c-myc mRNA in HL-60 leukemia cells

International Nuclear Information System (INIS)

Simpson, R.U.; Bresnick, E.H.; Begley, D.A.

1986-01-01

Recently, 1,25 was shown to induce differentiation and decrease c-myc levels in HL-60 cells. The authors have confirmed these observations by RNA dot blot analysis. Cells treated with 50 nM 1,25 for 4, 24 and 48 hr showed c-myc mRNA levels of 26, 17 and 15% of control respectively. β-Actin mRNA levels were not altered. To ascertain whether 1, 25 regulated c-myc transcriptionally, an HL-60 nuclear RNA runoff assay was developed. Assay of total nuclei transcriptional activity revealed that 50% of RNA elongation was α-amanitin (0.8 μg/ml) sensitive and was linear with nuclei concentration (0.1-1 x 10 7 nuclei). 1,25 (50 nM) treated (45-96 hr) cells had decreased (approx.40%) total transcription rate relative to control. Decreased total RNA synthesis occurred concomitant with NBT reducing activity. 32 P-RNA runoff transcripts from HL-60 nuclei were hybridized to excess (5 μg DNA was excess) Pst I linearized c-myc and β-actin clones (in pBR322) immobilized on nitrocellulose filter. 32 P-RNA input from 2 x 10 6 to 2 x 10 7 cpm yielded linear hybridization signal. Analysis of blot dot intensity revealed no difference in transcription of c-myc in nuclei from 1,25 dosed or control cells. (myc/actin ratios: 1,25 (50 nM, 72 hr) =1.1 +/- 0.3 and control (72 hr) = 1.0, N=3 or 2 or 3 dots ea). These preliminary data suggest 1,25 does not affect c-myc transcription in HL-60 nuclei and may regulate c-myc mRNA post-transcriptionally

Down-regulation of procaspase-8 expression by focal adhesion kinase protects HL-60 cells from TRAIL-induced apoptosis

International Nuclear Information System (INIS)

Tamagiku, Yuji; Sonoda, Yoshiko; Kunisawa, Mari; Ichikawa, Daiju; Murakami, Yayoi; Aizu-Yokota, Eriko; Kasahara, Tadashi

2004-01-01

We have demonstrated that focal adhesion kinase (FAK)-overexpressed (HL-60/FAK) cells have marked resistance against various apoptotic stimuli such as hydrogen peroxide, etoposide, and ionizing radiation compared with the vector-transfected (HL-60/Vect) cells. HL-60/FAK cells are highly resistant to TRAIL-induced apoptosis, while original HL-60 or HL-60/Vect cells were sensitive. TRAIL at 500 ng/ml induced significant DNA fragmentation, activation of caspase-8 and 3, the processing of a proapoptotic BID, and mitochondrial release of cytochrome c in HL-60/Vect cells, whereas no such events were observed in the HL-60/FAK cells. In particular, the expression of procaspase-8 gene and subsequent cleavage of caspase-8 were markedly reduced in HL-60/FAK cells, while expression of TRAIL-receptor 2 and 3, TRADD, and FADD was equivalent in both types of cells. In HL-60/FAK cells, the phosphoinositide 3 (PI3)-kinase/Akt survival pathway was constitutively activated, accompanied by significant induction of inhibitor-of-apoptosis proteins, XIAP, RIP, and Bcl-XL. The introduction of FAK siRNA in HL-60/FAK cells sensitized them against TRAIL-induced apoptosis, confirming that overexpressed FAK downregulates procaspase-8 expression, which subsequently inhibits downstream apoptosis pathway in the HL-60/FAK cells

Multi-channel time-division integrator in HL-2A

International Nuclear Information System (INIS)

Yan Ji

2008-01-01

HL-2A is China's first Tokamak device with divertor configuration (magnetic confinement controlled nuclear fusion device). To find out the details of on-going fusion reaction at different times is of important significance in achieving controlled nuclear fusion. We developed a new type multi-channel time-division integrator for HL-2A. It has functions of automatic cutting off negative pulse of the input signals, optional integrating time division spacing 0.2-1 ms, TTL starting trigger signal, automatic regularly work 20 s, and integrating 10 channel at the same time. (authors)

Wilson lines for AdS5 black strings

International Nuclear Information System (INIS)

Hristov, Kiril; Katmadas, Stefanos

2015-01-01

We describe a simple method of extending AdS 5 black string solutions of 5d gauged supergravity in a supersymmetric way by addition of Wilson lines along a circular direction in space. When this direction is chosen along the string, and due to the specific form of 5d supergravity that features Chern-Simons terms, the existence of magnetic charges automatically generates conserved electric charges in a 5d analogue of the Witten effect. Therefore we find a rather generic, model-independent way of adding electric charges to already existing solutions with no backreaction from the geometry or breaking of any symmetry. We use this method to explicitly write down more general versions of the Benini-Bobev black strings (http://dx.doi.org/10.1103/PhysRevLett.110.061601, http://dx.doi.org/10.1007/JHEP06(2013)005) and comment on the implications for the dual field theory and the similarities with generalizations of the Cacciatori-Klemm black holes (http://dx.doi.org/10.1007/JHEP01(2010)085) in AdS 4 .

The CMS ECAL Upgrade for Precision Crystal Calorimetry at the HL-LHC

CERN Document Server

Petyt, David Anthony

2018-01-01

The electromagnetic calorimeter (ECAL) of the Compact Muon Solenoid Experiment (CMS) is operating at the Large Hadron Collider (LHC) in 2016 with proton-proton collisions at 13 TeV center-of-mass energy and at a bunch spacing of 25 ns. Challenging running conditions for CMS are expected after the High-Luminosity upgrade of the LHC (HL-LHC). We review the design and R and D studies for the CMS ECAL crystal calorimeter upgrade and present first test beam studies. Particular challenges at HL-LHC are the harsh radiation environment, the increasing data rates and the extreme level of pile-up events, with up to 200 simultaneous proton-proton collisions. We present test beam results of hadron irradiated PbWO$_{4}$ crystals up to fluences expected at the HL-LHC. We also report on the R and D for the new readout and trigger electronics, which must be upgraded due to the increased trigger and latency requirements at the HL-LHC.

HL-LHC and HE-LHC Upgrade Plans and Opportunities for US Participation

Science.gov (United States)

Apollinari, Giorgio

2017-01-01

The US HEP community has identified the exploitation of physics opportunities at the High Luminosity-LHC (HL-LHC) as the highest near-term priority. Thanks to multi-year R&D programs, US National Laboratories and Universities have taken the leadership in the development of technical solutions to increase the LHC luminosity, enabling the HL-LHC Project and uniquely positioning this country to make critical contributions to the LHC luminosity upgrade. This talk will describe the shaping of the US Program to contribute in the next decade to HL-LHC through newly developed technologies such as Nb3Sn focusing magnets or superconducting crab cavities. The experience gained through the execution of the HL-LHC Project in the US will constitute a pool of knowledge and capabilities allowing further developments in the future. Opportunities for US participations in proposed hadron colliders, such as a possible High Energy-LHC (HE-LHC), will be described as well.

Will ALICE run in the HL-LHC era?

International Nuclear Information System (INIS)

Wessels, J.P.

2012-01-01

We will present the perspectives for ion running in the HL-LHC era. In particular, ALICE is preparing a significant upgrade of its rate capabilities and is further extending its particle identification potential. This paves the way for heavy ion physics at unprecedented luminosities, which are expected in the HL-LHC era with the heaviest ions. Here, we outline a scenario, in which ALICE will be taking data at a luminosity of L > 6*10 27 cm -2 *s -1 for Pb-Pb with the aim of collecting at least 10 nb -1 . The potential interest of data-taking during high luminosity proton runs for ATLAS and CMS will also be commented. (author)

Upper limits to the detection of ammonia from protoplanetary disks around HL Tauri and L1551-IRS 5

Science.gov (United States)

Gomez, Jose F.; Torrelles, Jose M.; Ho, Paul T. P.; Rodriguez, Luis F.; Canto, Jorge

1993-01-01

We present NH3(1, 1) and (2, 2) observations of the young stellar sources HL Tau and L1551-IRS 5 using the VLA in its B-configuration, which provides an angular resolution of about 0.4 arcsec (about 50 AU at 140 pc) at 1.3 cm wavelength. Our goal was to detect and resolve circumstellar molecular disks with radius of the order of 100 AU around these two sources. No ammonia emission was detected toward either of them. The 3-sigma levels were 2.7 mJy/beam and 3.9 mJy/beam for HL Tau and L1551-IRS 5, respectively, with a velocity resolution of about 5 km/s. With this nondetection, we estimate upper limits to the mass of the proposed protoplanetary molecular disks (within a radius of 10 AU from the central stars) on the order of 0.02/(X(NH3)/10 exp -8) solar mass for HL Tau and 0.1/(X(NH3)/10 exp -8) solar mass for L1551-IRS 5.

New botanical drug, HL tablet, reduces hepatic fat as measured by magnetic resonance spectroscopy in patients with nonalcoholic fatty liver disease: A placebo-controlled, randomized, phase II trial.

Science.gov (United States)

Jeong, Jae Yoon; Sohn, Joo Hyun; Baek, Yang Hyun; Cho, Yong Kyun; Kim, Yongsoo; Kim, Hyeonjin

2017-08-28

To evaluate the efficacy and safety of HL tablet extracted from magnolia officinalis for treating patients with nonalcoholic fatty liver disease (NAFLD). Seventy-four patients with NAFLD diagnosed by ultrasonography were randomly assigned to 3 groups given high dose (400 mg) HL tablet, low dose (133.4 mg) HL tablet and placebo, respectively, daily for 12 wk. The primary endpoint was post-treatment change of hepatic fat content (HFC) measured by magnetic resonance spectroscopy. Secondary endpoints included changes of serum aspartate aminotransferase, alanine aminotransferase (ALT), cholesterol, triglyceride, free fatty acid, homeostasis model assessment-estimated insulin resistance, and body mass index (BMI). The mean HFC of the high dose HL group, but not of the low dose group, declined significantly after 12 wk of treatment (high dose vs placebo, P = 0.033; low dose vs placebo, P = 0.386). The mean changes of HFC from baseline at week 12 were -1.7% ± 3.1% in the high dose group ( P = 0.018), -1.21% ± 4.97% in the low dose group ( P = 0.254) and 0.61% ± 3.87% in the placebo group (relative changes compared to baseline, high dose were: -12.1% ± 23.5%, low dose: -3.2% ± 32.0%, and placebo: 7.6% ± 44.0%). Serum ALT levels also tended to decrease in the groups receiving HL tablet while other factors were unaffected. There were no moderate or severe treatment-related safety issues during the study. HL tablet is effective in reducing HFC without any negative lipid profiles, BMI changes and adverse effects.

Ageing studies of resistive Micromegas detectors for the HL-LHC

CERN Document Server

Galán, J; Ferrer-Ribas, E; Giganon, A; Giomataris, I; Herlant, S; Jeanneau, F; Peyaud, A; Schune, Ph; Alexopoulos, T; Byszewski, M; Iakovidis, G; Iengo, P; Ntekas, K; Leontsinis, S; de Oliveira, R; Tsipolitis, Y; Wotschack, J

2013-01-01

Resistive-anode Micromegas detectors are in development since several years, in an effort to solve the problem of sparks when working in high flux and high radiations environment like in the HL-LHC (ten times the luminosity of the LHC). They have been chosen as one of the technologies that will be part of the ATLAS New Small Wheel project (forward muon system). An ageing study is mandatory to assess their capabilities to handle the HL-LHC environment on a long-term period. A prototype has been exposed to several types of irradiations (X-rays, cold neutrons, 60 Co gammas) up to an equivalent HL-LHC time of more than five years without showing any degradation of the performances in terms of gain and energy resolution. Beam test studies took place in October 2012 to assess the tracking performances (efficiency, spatial resolution,...). Results of ageing studies and beam test performances are reported in this paper.

Super and ferric: the first HL-LHC component is ready

CERN Multimedia

Antonella Del Rosso

2016-01-01

Although the actual installation phase in the tunnel will only start in 2024, the first magnet – a sextupole – of the High-Luminosity LHC (HL-LHC) is ready and working according to specifications. This first component is also rather unique as, unlike the superconducting magnets currently used in the LHC, it relies on a “superferric” heart.   An expert in the LASA Laboratory (INFN Milan, Italy) works on assembling the first sextupole corrector of the HL-LHC. (Image: INFN Milan) Although the name might sound completely unfamiliar, superferric magnets were first proposed in the 1980s as a possible solution for high-energy colliders. However, many technical problems had to be overcome before the use of superferric magnets could become a reality. In its final configuration, the HL-LHC will have 36 superferric corrector magnets, of which 4 will be quadrupoles, 8 sextupoles and 24 higher order magnets. In superferric (or “iron-dominated”) magne...

Performance and Operational Aspects of HL-LHC Scenarios

CERN Document Server

Medina Medrano, Luis

2016-01-01

Several alternatives to the present HL-LHC baseline configuration have been proposed, aiming either to improve the potential performance, reduce its risks, or to provide options for addressing possible limitations or changes in its parameters. In this paper we review and compare the performance of the HL-LHC baseline and the main alternatives with the latest parameters set. The results are obtained using refined simulations of the evolution of the luminosity with β^{*}-levelling, for which new criteria have been introduced, such as improved calculation of the intrabeam scattering and the addition of penalty steps to take into account the necessary time to move between consecutive optics during the process. The features of the set of optics are discussed for the nominal baseline.

Performances of the HL (Hyperloop) transport system

NARCIS (Netherlands)

van Goeverden, C.D.; Milakis, D.; Janic, M.; Konings, J.W.; Cools, M.; Limbourg, S.

2017-01-01

This paper deals with an analysis of performances of the HL (Hyperloop) transport system considered as an advanced transport alternative to the existing APT (Air Passenger Transport) and HSR (High Speed Rail) systems. The considered performances are operational, financial, social and environmental.

Concept design for the central control system of HL-2A

International Nuclear Information System (INIS)

Song Xianming; Li Qiang; Jiang Chao

2001-01-01

The design principle and basic structure of the central control system for HL-2A Tokamak are introduced. Having been limited by manpower and money, the central control system should not be too expensive and too advanced. On the other hand, because of the complexity of the machine and the difficulty the author will encounter when operating the machine, the central control system should be advanced enough. If use the same technology for HL-1M to control HL-2A, the author would fail to fulfill authors' experiment goal. The central control system consists of software and hardware. The software mainly includes: (a) system monitor and control software; (b) discharge monitor and control software; (c) network and communication software. Hardware includes: (a) PLC for machine control, personnel protection and machine protection; and (b) VME computer, for the feedback control of the discharge

Characterized the pattern of the material deposition in the HL-2A tokamak

Energy Technology Data Exchange (ETDEWEB)

Cai, Laizhong, E-mail: cailz@swip.ac.cn [Southwestern Institute of Physics, P.O.Box 432, Chengdu, Sichuan 610041 (China); Wang, Jianbao; Wu, Ting; Zeng, Xiaoxiao [Southwestern Institute of Physics, P.O.Box 432, Chengdu, Sichuan 610041 (China); Hai, Ran; Ding, Hongbin [Dalian University of Technology, Dalian, Liaoning 116024 (China)

2017-03-15

Since the divertor geometry of a tokamak has a strong impact on the material erosion and deposition on the wall and HL-2A has a unique divertor configuration, it is necessary to investigate the material deposition pattern in HL-2A although a few results on other tokamaks have already been published. In this paper, tiles retrieved from the vessel are analyzed ex-situ by SIMS, SEM and laser-induced breakdown spectroscopy (LIBS). And deposition behind the lower divertor is in-situ measured by a quartz crystal microbalance (QMB). The deposition in HL-2A displays a complex pattern and clear localization characteristic. The thickness of the deposition layer varies in the range of 0-4μm. And in-situ diagnostic of QMB indicates that the average thickness of the deposition layer per pulse is over ten nanometers. In addition, the results imply that Si, Fe and D have different behaviors during the material deposition in HL-2A.

High-Luminosity Large Hadron Collider (HL-LHC) : Preliminary Design Report

Energy Technology Data Exchange (ETDEWEB)

Apollinari, G. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Béjar Alonso, I. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Brüning, O. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Lamont, M. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Rossi, L. [European Organization for Nuclear Research (CERN), Geneva (Switzerland)

2015-12-17

The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community of about 7,000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its luminosity (rate of collisions) by a factor of five beyond the original design value and the integrated luminosity (total collisions created) by a factor ten. The LHC is already a highly complex and exquisitely optimised machine so this upgrade must be carefully conceived and will require about ten years to implement. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11-12 tesla superconducting magnets, compact superconducting cavities for beam rotation with ultra-precise phase control, new technology and physical processes for beam collimation and 300 metre-long high-power superconducting links with negligible energy dissipation. The present document describes the technologies and components that will be used to realise the project and is intended to serve as the basis for the detailed engineering design of HL-LHC.

High-Luminosity Large Hadron Collider (HL-LHC) : Preliminary Design Report

International Nuclear Information System (INIS)

Apollinari, G.; Béjar Alonso, I.; Brüning, O.; Lamont, M.; Rossi, L.

2015-01-01

The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community of about 7,000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its luminosity (rate of collisions) by a factor of five beyond the original design value and the integrated luminosity (total collisions created) by a factor ten. The LHC is already a highly complex and exquisitely optimised machine so this upgrade must be carefully conceived and will require about ten years to implement. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11-12 tesla superconducting magnets, compact superconducting cavities for beam rotation with ultra-precise phase control, new technology and physical processes for beam collimation and 300 metre-long high-power superconducting links with negligible energy dissipation. The present document describes the technologies and components that will be used to realise the project and is intended to serve as the basis for the detailed engineering design of HL-LHC.

Synthesis of minoxidil conjugates and their evaluation as HL-60 differentiation agents.

Science.gov (United States)

Stoica, Sonia; Magoulas, George E; Antoniou, Antonia I; Suleiman, Sherif; Cassar, Analisse; Gatt, Lucienne; Papaioannou, Dionissios; Athanassopoulos, Constantinos M; Schembri-Wismayer, Pierre

2016-02-15

Activation of minoxidil (MNX) with N,N'-carbonyldiimidazole and coupling with natural polyamines (PAs) and commercially available aliphatic or aromatic amines provided a series of new conjugates which were evaluated for their ability to induce differentiation to HL-60 acute myeloid leukemia cancer cells, using a modified NBTZ reduction test. Although neither MNX nor 4,4'-methylenedianiline (MDA) or 2,7-diaminofluorene (DAF), alone or in combination, had any effect, the MNX-spermine (SPM) conjugate (11) and the conjugates 7 and 8 of MNX with MDA and DAF exhibited a differentiation-inducing effect at a concentration of 10 μM without being toxic on proliferating human peripheral blood mononuclear cells. Copyright © 2016 Elsevier Ltd. All rights reserved.

Recombinant Chimpanzee Adenovirus Vaccine AdC7-M/E Protects against Zika Virus Infection and Testis Damage.

Science.gov (United States)

Xu, Kun; Song, Yufeng; Dai, Lianpan; Zhang, Yongli; Lu, Xuancheng; Xie, Yijia; Zhang, Hangjie; Cheng, Tao; Wang, Qihui; Huang, Qingrui; Bi, Yuhai; Liu, William J; Liu, Wenjun; Li, Xiangdong; Qin, Chuan; Shi, Yi; Yan, Jinghua; Zhou, Dongming; Gao, George F

2018-03-15

The recent outbreak of Zika virus (ZIKV) has emerged as a global health concern. ZIKV can persist in human semen and be transmitted by sexual contact, as well as by mosquitoes, as seen for classical arboviruses. We along with others have previously demonstrated that ZIKV infection leads to testis damage and infertility in mouse models. So far, no prophylactics or therapeutics are available; therefore, vaccine development is urgently demanded. Recombinant chimpanzee adenovirus has been explored as the preferred vaccine vector for many pathogens due to the low preexisting immunity against the vector among the human population. Here, we developed a ZIKV vaccine based on recombinant chimpanzee adenovirus type 7 (AdC7) expressing ZIKV M/E glycoproteins. A single vaccination of AdC7-M/E was sufficient to elicit potent neutralizing antibodies and protective immunity against ZIKV in both immunocompetent and immunodeficient mice. Moreover, vaccinated mice rapidly developed neutralizing antibody with high titers within 1 week postvaccination, and the elicited antiserum could cross-neutralize heterologous ZIKV strains. Additionally, ZIKV M- and E-specific T cell responses were robustly induced by AdC7-M/E. Moreover, one-dose inoculation of AdC7-M/E conferred mouse sterilizing immunity to eliminate viremia and viral burden in tissues against ZIKV challenge. Further investigations showed that vaccination with AdC7-M/E completely protected against ZIKV-induced testicular damage. These data demonstrate that AdC7-M/E is highly effective and represents a promising vaccine candidate for ZIKV control. IMPORTANCE Zika virus (ZIKV) is a pathogenic flavivirus that causes severe clinical consequences, including congenital malformations in fetuses and Guillain-Barré syndrome in adults. Vaccine development is a high priority for ZIKV control. In this study, to avoid preexisting anti-vector immunity in humans, a rare serotype chimpanzee adenovirus (AdC7) expressing the ZIKV M

Uric acid disrupts hypochlorous acid production and the bactericidal activity of HL-60 cells.

Science.gov (United States)

Carvalho, Larissa A C; Lopes, João P P B; Kaihami, Gilberto H; Silva, Railmara P; Bruni-Cardoso, Alexandre; Baldini, Regina L; Meotti, Flavia C

2018-06-01

Uric acid is the end product of purine metabolism in humans and is an alternative physiological substrate for myeloperoxidase. Oxidation of uric acid by this enzyme generates uric acid free radical and urate hydroperoxide, a strong oxidant and potentially bactericide agent. In this study, we investigated whether the oxidation of uric acid and production of urate hydroperoxide would affect the killing activity of HL-60 cells differentiated into neutrophil-like cells (dHL-60) against a highly virulent strain (PA14) of the opportunistic pathogen Pseudomonas aeruginosa. While bacterial cell counts decrease due to dHL-60 killing, incubation with uric acid inhibits this activity, also decreasing the release of the inflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF- α). In a myeloperoxidase/Cl - /H 2 O 2 cell-free system, uric acid inhibited the production of HOCl and bacterial killing. Fluorescence microscopy showed that uric acid also decreased the levels of HOCl produced by dHL-60 cells, while significantly increased superoxide production. Uric acid did not alter the overall oxidative status of dHL-60 cells as measured by the ratio of reduced (GSH) and oxidized (GSSG) glutathione. Our data show that uric acid impairs the killing activity of dHL-60 cells likely by competing with chloride by myeloperoxidase catalysis, decreasing HOCl production. Despite diminishing HOCl, uric acid probably stimulates the formation of other oxidants, maintaining the overall oxidative status of the cells. Altogether, our results demonstrated that HOCl is, indeed, the main relevant oxidant against bacteria and deviation of myeloperoxidase activity to produce other oxidants hampers dHL-60 killing activity. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Autoradiographic imaging of cerebral ischemia using hypoxic marker: Tc-99m-HL91 in animal models

International Nuclear Information System (INIS)

Jiang, N.Y.; Zhu, C.S.; Hu, X.K.

2002-01-01

Objective: To explore the possibility of Tc-99m-HL91 imaging in detecting the ischemic penumbra during acute stoke. Methods: 16 Sprague-Dawley (SD) rats were divided into operation group (n=12) and pseudo-operation group (n=4) randomly. In operation group, 12 middle cerebral artery occlusion animal (MCAO) models were established by electrocautery. 4 rats in pseudo-operation group were treated as a control without occlusion. All animals were injected Tc-99m-HL91 intravenously 2 hours after occlusion. Animals were killed at different time after injection and brains were removed rapidly from the skull to do the autoradiographic study. Result: The ischemic territory accumulated more Tc-99m-HL91 than the opposite site in the autoradiogram at 1 hour after injection. The ischemic cerebral tissue can be visualized clearly. At 2, 4 hours after injection, the difference of accumulation of Tc-99m-HL91 in target and non-target site became more obvious. By using computer-enhanced imaging analysis, the optical density (OD) ratio differences between each subgroup of operation group and pseudo-operation group were all significant. Conclusion : Tc-99m-HL91 can be avidly taken up by ischemic penumbra. Tc-99m-HL91 is a potential agent for imaging hypoxic tissue, and Tc-99m-HL91 SPECT may be a promising imaging method in detecting the ischemic penumbra

Autoradiographic imaging of cerebral ischaemia using hypoxic marker: 99mTc-HL91 in animal models

International Nuclear Information System (INIS)

Ningyi, J.; Cansheng, Z.; Xiaoke, H.

2002-01-01

Objective: To explore the possibility of 99mTc-HL91 imaging in detecting the ischemic penumbra during acute stoke. Methods 16 Sprague-Dawley (SD) rats were divided into operation group (n=12) and pseudo-operation group (n=4) randomly. In operation group, 12 middle cerebral artery occlusion animal (MCAO) models were established by electrocautery. 4 rats in pseudo-operation group were treated as a control without occlusion. All animals were injected 99mTc-HL91 intravenously 2 hours after occlusion. Animals were killed at different time after injection and brains were removed rapidly from the skull to do the autoradiographic study. Result The ischemic territory accumulated more 99mTc-HL91 than the opposite site in the autoradiogram at 1 hour after injection. The ischemic cerebral tissue can be visualized clearly. At 2, 4 hours after injection, the difference of accumulation of 99mTc-HL91 in target and non-target site became more obvious. By using computer-enhanced imaging analysis, the optical density (OD) ratio differences between each subgroup of operation group and pseudo-operation group were all significant. Conclusion 99mTc-HL91 can be avidly taken up by ischemic penumbra. 99mTc-HL91 is a potential agent for imaging hypoxic tissue, and 99mTc-HL91 SPECT may be a promising imaging method in detecting the ischemic penumbra

Upgrades of the CMS muon system in preparation of HL-LHC

CERN Document Server

Teyssier, Daniel Francois

2017-01-01

The present CMS muon system operates three different detector types in the barrel drift tubes (DT) and resistive plate chambers (RPC), along with cathode strip chambers (CSC) and another set of RPCs in the forward regions. In order to cope with increasingly challenging conditions various upgrades are planned to the trigger and muon systems. New detectors will be added to improve the performance in the critical forward region large-area triple-foil gas electron multiplier (GEM) detectors will already be installed in LS2 in the pseudo-rapidity region $1.6 < \\eta < 2.4$, aiming at suppressing the rate of background triggers while maintaining high trigger efficiency for low transverse momentum muons. For the High Luminosity (HL)-LHC operations, the muon forward region should be enhanced with another large area GEM based station, called GE2/1, and with two new generation RPC stations, called RE3/1 and RE4/1, having low resistivity electrodes. These detectors will combine tracking and triggering capabil...

HL-1 tokamak data acquisition system and its initial application in the physical experiment

International Nuclear Information System (INIS)

Deng Huichen; Fu Bo; Dong Jiafu

1989-11-01

A HL-1 tokamak data acquisition system has been developed and has been used in the physical experiment. The hardware and software configuration of the system, as well as the typical acquired data in the HL-1 experiment are introduced

The CMS Tracker upgrade for HL-LHC

CERN Document Server

Ahuja, Sudha

2017-01-01

The LHC machine is planning an upgrade program which will smoothly bring the luminosity to about 5 $\\times$ $10^{34} $cm$^{-2}$s$^{-1}$ in 2028, to possibly reach an integrated luminosity of 3000 fb$^{-1}$ by the end of 2037. This High Luminosity LHC scenario, HL-LHC, will require a preparation program of the LHC detectors known as Phase-2 upgrade. The current CMS Outer Tracker, already running beyond design specifications, and CMS Phase1 Pixel Detector will not be able to survive HL-LHC radiation conditions and CMS will need completely new devices, in order to fully exploit the high-demanding operating conditions and the delivered luminosity. The new Outer Tracker should have also trigger capabilities. To achieve such goals, R$\\&$D activities are ongoing to explore options both for the Outer Tracker, and for the pixel Inner Tracker. Solutions are being developed that would allow including tracking information at Level-1. The design choices for the Tracker upgrades are discussed along with some highlights...

Design for effective development and prototyping of the HL-20

Science.gov (United States)

Urie, David M.; Floreck, Paul A.; McMorris, John A.; Elvin, John D.

1993-10-01

A feasibility study of the HL-20 personnel launch system (PLS) concept was conducted by a team which focused on creating a PLS design approach and an accelerated development plan consistent with the historical 'Skunk Works' approach to rapid prototyping. Technical design, manufacturing, system testing, and operations and support elements of the predefined baseline concept were evaluated. An initial phase program, featuring a concurrent system test during design and development, leading to the orbital flight of an unmanned HL-20 prototype on a Titan III launch system, was prescribed. A second-phase development and manufacturing plan leading to system operational status was also formulated. Baseline design feature modifications were made when necessary, without compromise to performance, to satisfy the prototype development plan. Technical design details and off-the-shelf hardware candidates were also identified for several subsystems, including the launch-system interface adapter/emergency escape system. The technical feasibility of the system and applicability of the Skunk Works approach to development of the HL-20/PLS were verified.

Dynamical Stability of Imaged Planetary Systems in Formation: Application to HL Tau

Science.gov (United States)

Tamayo, D.; Triaud, A. H. M. J.; Menou, K.; Rein, H.

2015-06-01

A recent Atacama Large Millimeter/Submillimeter Array image revealed several concentric gaps in the protoplanetary disk surrounding the young star HL Tau. We consider the hypothesis that these gaps are carved by planets, and present a general framework for understanding the dynamical stability of such systems over typical disk lifetimes, providing estimates for the maximum planetary masses. We collect these easily evaluated constraints into a workflow that can help guide the design and interpretation of new observational campaigns and numerical simulations of gap opening in such systems. We argue that the locations of resonances should be significantly shifted in massive disks like HL Tau, and that theoretical uncertainties in the exact offset, together with observational errors, imply a large uncertainty in the dynamical state and stability in such disks. This presents an important barrier to using systems like HL Tau as a proxy for the initial conditions following planet formation. An important observational avenue to breaking this degeneracy is to search for eccentric gaps, which could implicate resonantly interacting planets. Unfortunately, massive disks like HL Tau should induce swift pericenter precession that would smear out any such eccentric features of planetary origin. This motivates pushing toward more typical, less massive disks. For a nominal non-resonant model of the HL Tau system with five planets, we find a maximum mass for the outer three bodies of approximately 2 Neptune masses. In a resonant configuration, these planets can reach at least the mass of Saturn. The inner two planets’ masses are unconstrained by dynamical stability arguments.

Autoradiographic imaging of cerebral ischemia using hypoxic marker: 99mTc-HL91 in animal models

International Nuclear Information System (INIS)

Zhu Cansheng; Jiang Ningyi; Hu Xiaoke

2001-01-01

Objective: To explore the possibility of 99m Tc-HL91 imaging in detecting the ischemic penumbra during acute stoke. Methods; 16 Sprague-Dawley (SD) rats were divided into operation group (n=12) and pseudo-operation group (n=4) randomly. In operation group, 12 middle cerebral artery occlusion animal (MCAO) models were established by electrocautery. 4 rats in pseudo-operation group were treated as a control without occlusion. All animals were injected 99m Tc-HL91 intravenously 2 hours after occlusion. Animals were killed at different time after injection and brains were removed rapidly from the skull to do the autoradiographic study. Results: The ischemic territory accumulated more 99m Tc-HL91 than the opposite site in the autoradiogram at 1 hour after injection. The ischemic cerebral tissue can be visualized clearly. At 2, 4 hours after injection, the difference of accumulation of 99m Tc-HL91 in target and non-target site became more obvious. By using computer-enhanced imaging analysis, the optical density (OD) ratio differences between each subgroup of operation group and pseudo-operation group were all significant. The OD ratios (T/N) were 1.2691±0.0189, 1.3542±0.0119, 2.1201±0.0616, 2.5369±0.1214 respectively at 1, 2, 4 hours after 99m Tc-HL91 injection. Conclusion: 99m Tc-HL91 can be avidly taken up by ischemic penumbra. 99m Tc-HL91 is a potential agent for imaging hypoxic tissue, and 99m Tc-HL91 SPECT may be a promising imaging method in detecting the ischemic penumbra

State Operator Correspondence and Entanglement in AdS2/CFT1

Directory of Open Access Journals (Sweden)

Ashoke Sen

2011-07-01

Full Text Available Since Euclidean global AdS2 space represented as a strip has two boundaries, the state-operator correspondence in the dual CFT1 reduces to the standard map from the operators acting on a single copy of the Hilbert space to states in the tensor product of two copies of the Hilbert space. Using this picture we argue that the corresponding states in the dual string theory living on AdS2 × K are described by the twisted version of the Hartle–Hawking states, the twists being generated by a large unitary group of symmetries that this string theory must possess. This formalism makes natural the dual interpretation of the black hole entropy—as the logarithm of the degeneracy of ground states of the quantum mechanics describing the low energy dynamics of the black hole, and also as an entanglement entropy between the two copies of the same quantum theory living on the two boundaries of global AdS2 separated by the event horizon.

Optimization of thin n-in-p planar pixel modules for the ATLAS upgrade at HL-LHC

International Nuclear Information System (INIS)

Macchiolo, A.; Beyer, J.; Rosa, A. La; Nisius, R.; Savic, N.

2017-01-01

The ATLAS experiment will undergo around the year 2025 a replacement of the tracker system in view of the high luminosity phase of the LHC (HL-LHC) with a new 5-layer pixel system. Thin planar pixel sensors are promising candidates to instrument the innermost region of the new pixel system, thanks to the reduced contribution to the material budget and their high charge collection efficiency after irradiation. The sensors of 50-150 μm thickness, interconnected to FE-I4 read-out chips, have been characterized with radioactive sources and beam tests. In particular active edge sensors have been investigated. The performance of two different versions of edge designs are compared: the first with a bias ring, and the second one where only a floating guard ring has been implemented. The hit efficiency at the edge has also been studied after irradiation at a fluence of 10 15  n eq /cm 2 . Highly segmented sensors will represent a challenge for the tracking in the forward region of the pixel system at HL-LHC. In order to reproduce the performance of 50x50 μm 2 pixels at high pseudo-rapidity values, FE-I4 compatible planar pixel sensors have been studied before and after irradiation in beam tests at high incidence angles with respect to the short pixel direction. Results on the hit efficiency in this configuration are discussed for different sensor thicknesses.

Using HL7 in hospital staff assignments.

Science.gov (United States)

Unluturk, Mehmet S

2014-02-01

Hospital staff assignments are the instructions that allocate the hospital staff members to the hospital beds. Currently, hospital administrators make the assignments without accessing the information regarding the occupancy of the hospital beds and the acuity of the patient. As a result, administrators cannot distinguish between occupied and unoccupied beds, and may therefore assign staff to unoccupied beds. This gives rise to uneven and inefficient staff assignments. In this paper, the hospital admission-discharge-transfer (ADT) system is employed both as a data source and an assignment device to create staff assignments. When the patient data is newly added or modified, the ADT system updates the assignment software client with the relevant data. Based on the relevant data, the assignment software client is able to construct staff assignments in a more efficient way. © 2013 Elsevier Ltd. All rights reserved.

Study on fast ion loss in HL-2A tokamak

International Nuclear Information System (INIS)

Liu Yi; Sun Tengfei; Ji Xiaoquan

2012-01-01

Experiments with a high-energy deuterium neutral beam (NB) injection (30 keV, about 0.6 MW) were performed on the HL-2A tokamak. Analysis of neutron decay following the NB 'blip' injection indicates that tangentially injected beam ions are well confined, slowing down classically in the HL-2A. Anomalous losses of beam ions were observed when a beta-induced Alfven acoustic (BAAE) mode was present in the plasma. Such a high energetic particle driven mode led to fast-ion loss, showing a strong influence of the energetic particle driven mode on the fast-ion transport. (authors)

A level-1 pixel based track trigger for the CMS HL-LHC upgrade

CERN Document Server

CMS Collaboration

2016-01-01

We present feasibility studies to investigate the performances and interest of a Level-1 trigger based on pixels. The Level-1 (real-time) pixel based tracking trigger is a novel trigger system that is based on the real-time track reconstruction algorithms able to cope with very high rates and high flux of data in a very harsh environment. The pixel detector has an especially crucial role in precisely identifying the primary vertex of the rare physics events from the large pile-up (PU) of events. The goal of adding the pixel information already at the real-time level of the selection is to help reducing the total level-1 trigger rate while keeping an high selection capability. This is quite an innovative and challenging objective for the experiments upgrade for the High Luminosity LHC (HL-LHC).

An ageing study of resistive micromegas for the HL-LHC environment

CERN Document Server

Galan, J.; Ferrer-Ribas, E.; Giganon, A.; Giomataris, I.; Herlant, S.; Jeanneau, F.; Peyaud, A.; Schune, Ph; Alexopoulos, T.; Byszewski, M.; Iakovidis, G.; Iengo, P.; Ntekas, K.; Leontsinis, S.; de Oliveira, R.; Tsipolitis, Y.; Wotschack, J.

2013-01-01

Resistive-anode micromegas detectors are in development since several years, in an effort to solve the problem of sparks when working at high flux and high ionizing radiation like in the HL-LHC (up to ten times the luminosity of the LHC). They have been chosen as one of the technologies that will be part of the ATLAS New Small Wheel project (forward muon system). An ageing study is mandatory to assess their capabilities to handle the HL-LHC environment on a long-term period. A prototype has been exposed to several types of irradiation (X-rays, cold neutrons, $^{60}$Co gammas and alphas) above the equivalent charge produced at the detector in five HL-LHC running years without showing any degradation of the performances in terms of gain and energy resolution. This study has been completed with the characterization of the tracking performances in terms of efficiency and spatial resolution, verifying the compatibility of results obtained with both resistive micromegas detectors, irradiated and non-irradiated one.

The conceptual design for the modification of HL-2A tokamak

International Nuclear Information System (INIS)

Dequan Liu

2006-01-01

The medium-sized tokamak HL-2A, based on the former ASDEX's main components has approached its rating operational parameters with I p = 450 kA and B T =2.8 T so far. The HL-2A was originally designed to operate under an axisymmetrical double-null configuration by two triplets of shaping coils located in the vacuum vessel. Because the shaping coils were set very close to the plasma column, the nulls are normally fixed and the plasma has a nearly circular cross-section. It is difficult to increase the parameters further and obtain a preferable plasma shape with certain values of triangularity and elongation. Due to the defects on upper shaping coils' electrical insulation, the HL-2A is presently just operated with lower single null divertor configuration. Additionally, the experiment has to occasionally terminate due to incidental damages of the weak parts. With the experimental progress on HL-2A, the plasma stored energy and auxiliary heating power is being increased, a more efficient, compact and tight divertor is needed. Based on present status of HL-2A tokamak and for satisfying the requirements of the experiment, the modification of HL-2A tokamak device will be carried out. The modification design of HL-2A intents to obtain optimized plasma parameters, e.g., aspect ratio, I p , b, plasma volume, certain plasma shaping with preferable elongation and triangularity, a stable vacuum vessel easy to be maintained and an advanced divertor. The primary consideration of the modification is to take all of the shaping coils out of the vessel to enlarge the plasma volume. The elongated and triangular cross section with double null of plasma is to be obtained by composite distribution of eight sets of poloidal coils. Because all poloidal coils will be located between the TF coil and the vessel, the vacuum vessel will be remade with a smaller size to make rooms for the poloidal coil system. With an optimized operation mode, the volt-second of the plasma may be increased a

Relationship of calcitonin mRNA expression to the differentiation state of HL 60 cells.

Science.gov (United States)

Kiefer, P; Bacher, M; Pflüger, K H

1994-05-01

Raised plasma levels of immunoreactive human calcitonin (ihCT) can be found in patients with myeloid leukemia and seem to indicate a poor prognosis. High levels were found in acute undifferentiated and acute myeloblastic leukemia. To test whether CT expression could be a marker of myeloid differentiation, we used the promyelocytic leukemia cell line HL 60 which also expresses ihCT as a model system for myeloid differentiation. Exponentially growing HL 60 cells as well as differentiation induced HL 60 cells expressed a single 1.0 Kb CT transcript. The induction of HL 60 cell differentiation along the granulocytic lineage by DMSO or HMBA had no effect on the level of CT transcripts. Induction of monocytic/macrophagic differentiation by TPA resulted in a transient, about 10-fold elevated expression of CT steady state mRNA after 24 h. In contrast to TPA, induction of HL 60 cell differentiation along the monocytic pathway by Vit D3 had no detectable effect on the level of the CT in RNA expression at corresponding time points. These findings suggest that the transient induction of CT steady state mRNA expression by TPA is rather a direct effect of the phorbol ester than commitment along the monocytic line of differentiation.

The Discharge Design of HL-2M with the Tokamak Simulation Code (TSC)

International Nuclear Information System (INIS)

Yudong Pan; Jardin, S.C.; Kes, C.

2007-01-01

We present results on the discharge design of the HL-2M tokamak, which is to be an upgrade to the existing HL-2A tokamak. We present simulation results for complete 5-sec. discharges, both double null and lower single null, for both ohmic and auxiliary heated discharges. We also discuss the vertical stability properties of the device

FGF-23 dysregulates calcium homeostasis and electrophysiological properties in HL-1 atrial cells.

Science.gov (United States)

Kao, Yu-Hsun; Chen, Yao-Chang; Lin, Yung-Kuo; Shiu, Rong-Jie; Chao, Tze-Fan; Chen, Shih-Ann; Chen, Yi-Jen

2014-08-01

Fibroblast growth factor (FGF)-23 is a key regulator of phosphate homeostasis. Higher FGF-23 levels are correlated with poor outcomes in cardiovascular diseases. FGF-23 can produce cardiac hypertrophy and increase intracellular calcium, which can change cardiac electrical activity. However, it is not clear whether FGF-23 possesses arrhythmogenic potential through calcium dysregulation. Therefore, the purposes of this study were to evaluate the electrophysiological effects of FGF-23 and identify the underlying mechanisms. Patch clamp, confocal microscope with Fluo-4 fluorescence, and Western blot analyses were used to evaluate the electrophysiological characteristics, calcium homeostasis and calcium regulatory proteins in HL-1 atrial myocytes with and without FGF-23 (10 and 25 ng/mL) incubation for 24 h. FGF-23 (25 ng/mL) increased L-type calcium currents, calcium transient and sarcoplasmic reticulum Ca(2+) contents in HL-1 cells. FGF-23 (25 ng/mL)-treated cells (n = 14) had greater incidences (57%, 17% and 15%, P calcium/calmodulin-dependent protein kinase IIδ and phospholamban (PLB) at threonine 17 but had similar phosphorylation extents of PLB at serine 16, total PLB and sarcoplasmic reticulum Ca(2+) -ATPase protein. Moreover, the FGF receptor inhibitor (PD173074, 10 nM), calmodulin inhibitor (W7, 5 μM) and phospholipase C inhibitor (U73122, 1 μM) attenuated the effects of FGF-23 on calcium/calmodulin-dependent protein kinase II phosphorylation. FGF-23 increases HL-1 cells arrhythmogenesis with calcium dysregulation through modulating calcium-handling proteins. © 2014 Stichting European Society for Clinical Investigation Journal Foundation.

AdS3/CFT2, finite-gap equations and massless modes

International Nuclear Information System (INIS)

Lloyd, Thomas; Stefański, Bogdan Jr.

2014-01-01

It is known that string theory on AdS 3 ×M 7 backgrounds, where M 7 =S 3 ×S 3 ×S 1 or S 3 ×T 4 , is classically integrable. This integrability has been previously used to write down a set of integral equations, known as the finite-gap equations. These equations can be solved for the closed string spectrum of the theory. However, it has been known for some time that the finite-gap equations on these AdS 3 ×M 7 backgrounds do not capture the dynamics of the massless modes of the closed string theory. In this paper we re-examine the derivation of the AdS 3 ×M 7 finite-gap system. We find that the conditions that had previously been imposed on these integral equations in order to implement the Virasoro constraints are too strict, and are in fact not required. We identify the correct implementation of the Virasoro constraints on finite-gap equations and show that this new, less restrictive condition captures the complete closed string spectrum on AdS 3 ×M 7

The Comparative PDT Experiment of the Inactivation of HL60 on Modified TiO2 Nanoparticles

Directory of Open Access Journals (Sweden)

Kaiqi Lu

2015-01-01

Full Text Available Four samples of modified titanium dioxide (TiO2, Fe/TiO2 (2 wt%, Fe/TiO2 (5 wt%, and 5-ALA/TiO2, were experimented in photodynamic therapy (PDT on leukemia cells HL60, performing promising photocatalytic inactivation effect. Fe/TiO2 and 5-ALA/TiO2 were synthesized in methods of precipitation and ultrasonic methods, respectively. X-ray diffraction spectra and UV-Vis spectra were studied for the samples’ crystalline phase and redshift of absorption peak. Further, FTIR spectra and Raman spectra were obtained to examine the combination of 5-aminolevulinic (5-ALA and TiO2 nanoparticles. The toxicity of these four kinds of nanoparticles was studied through darkroom experiments. And based on the concentration which caused the same toxic effect (90% on HL60, PDT experiments of TiO2, Fe/TiO2 (2%, Fe/TiO2 (5%, and ALA/TiO2 were done, resulting in the fact that the photokilling efficiency was 69.7%, 71.6%, 72%, and 80.6%, respectively. Scanning electron microscope (SEM images of the samples were also taken to study the morphology of HL60 cells before and after PDT, resulting in the fact the activation of the modified TiO2 from PDT was the main cause of cell apoptosis.

Clock Distribution and Readout Architecture for the ATLAS Tile Calorimeter at the HL-LHC

CERN Document Server

Carrio Argos, Fernando; The ATLAS collaboration

2018-01-01

The Tile Calorimeter (TileCal) is one detector of the ATLAS experiment at the Large Hadron Collider (LHC). TileCal is a sampling calorimeter made of steel plates and plastic scintillators which are readout using approximately 10,000 PhotoMultipliers Tubes (PMTs). In 2024, the LHC will undergo a series of upgrades towards a High Luminosity LHC (HL-LHC) to deliver up to 7.5 times the current nominal instantaneous luminosity. The ATLAS Tile Phase II Upgrade will accommodate detector and data acquisition system to the HL-LHC requirements. The detector electronics will be redesigned using a new clock distribution and readout architecture with a full-digital trigger system. After the Long Shutdown 3 (2024-2026), the on-detector electronics will transfer digitized data for every bunch crossing (~25 ns) to the Tile PreProcessors (TilePPr) in the counting rooms with a total data bandwidth of 40 Tbps. The TilePPrs will store the detector data in pipeline memories to cope with the new ATLAS DAQ architecture requirements...

Adult Hodgkin Lymphoma Treatment (PDQ®)—Health Professional Version

Science.gov (United States)

Adult Hodgkin lymphoma (HL) can be cured in over 75% of new cases with combination chemotherapy and/or radiation therapy. Subtypes include classical HL (nodular sclerosis mixed-cellularity, lymphocyte depletion, and lymphocyte-rich) and nodular lymphocyte–predominant HL. Get comprehensive information on HL and treatment in this clinician summary.

Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells.

Science.gov (United States)

Inayat-Hussain, S H; Annuar, B O; Din, L B; Ali, A M; Ross, D

2003-08-01

Styryl-lactones such as goniothalamin represent a new class of compounds with potential anti-cancer properties. In this study, we investigated the mechanisms of goniothalamin (GTN), a plant styryl-lactone induced apoptosis in human promyelocytic leukemia HL-60 cells. This plant extract resulted in apoptosis in HL-60 cells as assessed by the externalisation of phosphatidylserine. Using the mitochondrial membrane dye (DIOC(6)) in conjunction with flow cytometry, we found that GTN treated HL-60 cells demonstrated a loss of mitochondrial transmembrane potential (Deltapsi(m)). Further immunoblotting on these cells showed activation of initiator caspase-9 and the executioner caspases-3 and -7. Pretreatment with the pharmacological caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp fluoromethyl ketone (Z-VAD.FMK) abrogated apoptosis as assessed by all of the apoptotic features in this study. In summary, our results demonstrate that goniothalamin-induced apoptosis occurs via the mitochondrial pathway in a caspase dependent manner.

Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells.

Science.gov (United States)

Costa, Patricia Marçal da; Ferreira, Paulo Michel Pinheiro; Bolzani, Vanderlan da Silva; Furlan, Maysa; de Freitas Formenton Macedo Dos Santos, Vânia Aparecida; Corsino, Joaquim; de Moraes, Manoel Odorico; Costa-Lotufo, Letícia Veras; Montenegro, Raquel Carvalho; Pessoa, Cláudia

2008-06-01

Pristimerin has been shown to be cytotoxic to several cancer cell lines. In the present work, the cytotoxicity of pristimerin was evaluated in human tumor cell lines and in human peripheral blood mononuclear cells (PBMC). This work also examined the effects of pristimerin (0.4; 0.8 and 1.7 microM) in HL-60 cells, after 6, 12 and 24h of exposure. Pristimerin reduced the number of viable cells and increased number of non-viable cells in a concentration-dependent manner by tripan blue test showing morphological changes consistent with apoptosis. Nevertheless, pristimerin was not selective to cancer cells, since it inhibited PBMC proliferation with an IC50 of 0.88 microM. DNA synthesis inhibition assessed by 5-bromo-2'-deoxyuridine (BrdU) incorporation in HL-60 cells was 70% and 83% for the concentrations of 0.4 and 0.8 microM, respectively. Pristimerin (10 and 20 microM) was not able to inhibit topoisomerase I. In AO/EB (acridine orange/ethidium bromide) staining, all tested concentrations reduced the number of HL-60 viable cells, with the occurrence of necrosis and apoptosis in a concentration-dependent manner, results in agreement with trypan blue exclusion findings. The analysis of membrane integrity and internucleosomal DNA fragmentation by flow cytometry in the presence of pristimerin indicated that treated cells underwent apoptosis. The present data point to the importance of pristimerin as representative of an emerging class of potential anticancer chemicals, exhibiting an antiproliferative effect by inhibiting DNA synthesis and triggering apoptosis.

The Supervisory Control System for the HL-2A Neutral Beam Injector

Science.gov (United States)

Li, Bo; Li, Li; Feng, Kun; Wang, Xueyun; Yang, Jiaxing; Huang, Zhihui; Kang, Zihua; Wang, Mingwei; Zhang, Guoqing; Lei, Guangjiu; Rao, Jun

2009-06-01

Supervisory control and protection system of the neutral beam injector (NBI) in the HL-2A tokamak is presented. The system is used for a safe coordination of all the main NBI subsystems. Because the system is based on computer networks with its transmission medium of optical fiber, its advantages in high operational stability, reliability, security and flexible functional expandability are clearly shown during the NBI commissioning and heating experiment in HL-2A.

Pulse discharge cleaning of the vacuum vessel of HL-1 tokamak

International Nuclear Information System (INIS)

Li Guodong; Zhu Yukun; Xiao Zhenggui; Sun Shouqi; Ze Mingrui

1986-01-01

The HL-1 Tokamak was test-operated on September 21, 1984. During the period of vacuum conditioning, including 60 hours of baking up to 200 deg C and 7 x 10 4 shots of pulse discharge cleaning, the calculated quantities of carbon and oxygen removed are equivalent to 24 and 6 monolayers, respectively. Then, 124 shots of tokamak discharge were performed with low level plasma parameters. The plasma current and pulse length achieved were 60 kA and 85 ms at the toroidal magnetic field of 15 kG. This paper described the techniques used and the effect on discharge characteristics of bakeout and pulse discharge cleaning of the vacuum vessel

On the HL-1M tokamak plasma confinement time

International Nuclear Information System (INIS)

Qin Yunwen

2001-01-01

Emphasizing that the tokamak plasma confinement time is the plasma particle or thermal energy loss characteristic time, the relevant physical concept and HL-1M tokamak experimental data analyses are reviewed

Development of a USB-based multi-channel time division scaler for HL-2A

International Nuclear Information System (INIS)

Liang Ping

2008-01-01

HL-2A is China's first Tokamak device with divertor configuration. Mastering the process and plasma parameter changes with time are of great significance to achieve controlled nuclear fusion. In the recent upgrading of HL-2A, for which a higher and faster electronic equipment was required, we developed a new type USB multi-channel time division scaler for HL-2A including functions: USB interface, PC graphical user interface, simultaneously calibrating more than five channel signals, optional time division spacing 2-50 ms, count rate up to over 2 MHz, accessing all the information 20 s after a activated signal, and processing data and displaying off-line. (authors)

Density Limits with Different Fuelling Methods in the HL-2A Tokamak

International Nuclear Information System (INIS)

Yan Longwen; Zhou Yan; Chen Chengyuan; Cao Zeng; Song Xianming; Li Wei; Dong Yunbo; Hong Wenyu; Yang Qingwei; Duan Xuru

2009-01-01

Density limits with different fuelling methods have been compared in HL-2A, i.e. direct gas puffing and supersonic molecular beam injection (SMBI) from outer midplane, and divertor gas fuelling. The maximum densities for low current discharges are 3.4x10 19 m -3 , 4.3x10 19 m -3 and 4.7x10 19 m -3 for the 3 kinds of fuelling methods. The corresponding density ratios to Greenwald density limit are 0.9, 1.1, 1.2, respectively. The behavior of density limit disruption is analyzed as well. (magnetically confined plasma)

Relationship between structure and antiproliferative activity of polymethoxyflavones towards HL60 cells.

Science.gov (United States)

Kawaii, Satoru; Ikuina, Tomoyasu; Hikima, Takeshi; Tokiwano, Tetsuo; Yoshizawa, Yuko

2012-12-01

As part of our continuing investigation of polymethoxyflavone (PMF) derivatives as potential anticancer substances, a series of PMF derivatives was synthesized. The synthesized compounds were evaluated for cytotoxicity against the promyelocytic leukemic HL60 cell line, and structure-activity relationship correlations were investigated along with previously isolated PMFs from the peel of king orange (Citrus nobilis). 7,3'-Dimethoxyflavone demonstrated the most potent activity among the synthetic PMFs. Consideration of correlation between the methoxylation pattern and antiproliferative activity revealed the importance of the 3'-methoxyl group and the higher degree of methoxylation on the A-ring moiety of PMFs.

HL-60 differentiating activity and flavonoid content of the readily extractable fraction prepared from citrus juices.

Science.gov (United States)

Kawaii, S; Tomono, Y; Katase, E; Ogawa, K; Yano, M

1999-01-01

Citrus plants are rich sources of various bioactive flavonoids. To eliminate masking effects caused by hesperidin, naringin, and neoeriocitrin, the abundant flavonoid glycosides which make up 90% of the conventionally prepared sample, the readily extractable fraction from Citrus juice was prepared by adsorbing on HP-20 resin and eluting with EtOH and acetone from the resin and was subjected to HL-60 differentiation assay and quantitative analysis of major flavonoids. Screening of 34 Citrus juices indicated that King (C. nobilis) had a potent activity for inducing differentiation of HL-60, and the active principles were isolated and identified as four polymethoxylated flavonoids, namely, nobiletin, 3,3',4',5,6,7, 8-heptamethoxyflavone, natsudaidain, and tangeretin. HPLC analysis of the readily extractable fraction also indicated that King contained high amounts of these polymethoxylated flavonoids among the Citrus juices examined. Principal component and cluster analyses of the readily extractable flavonoids indicated peculiarities of King and Bergamot.

The CMS ECAL Upgrade for Precision Crystal Calorimetry at the HL-LHC

CERN Document Server

Jofrehei, Arash

2017-01-01

The Compact Muon Solenoid Experiment (CMS) is operating at the Large Hadron Collider (LHC) with proton-proton collisions at 13 TeV center-of-mass energy and at a bunch spacing of 25 ns. Challenging running conditions for CMS are expected after the High-Luminosity upgrade of the LHC (HL-LHC). We review the CMS ECAL crystal calorimeter upgrade and present results from the first test beam studies. Particular challenges at HL-LHC are the harsh radiation environment, the increasing data rates and the extreme level of pile-up events, with up to 200 simultaneous proton-proton collisions. Precision timing can be exploited to reduce the effect of the pile-up. We report on the timing resolution studies performed with test-beams. We discuss the new readout and trigger electronics, which must be upgraded due to the increased trigger and latency requirements at the HL-LHC.

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes

International Nuclear Information System (INIS)

Pai, J.K.; Siegel, M.I.; Egan, R.W.; Billah, M.M.

1988-01-01

There exists circumstantial evidence for activation of phospholipase D (PLD) in intact cells. However, because of the complexity of phospholipid remodeling processes, it is essential to distinguish PLD clearly from other phospholipases and phospholipid remodeling enzymes. Therefore, to establish unequivocally PLD activity in dimethyl sulfoxide-differentiated HL-60 granulocytes, to demonstrate the relative contribution of PLD to phospholipid turnover, and to validate the hypothesis that the formation of phosphatidylethanol is an expression of PLD-catalyzed transphosphatidylation, we have developed methodologies to label HL-60 granulocytes in 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (alkyl-PC) with 32P without labeling cellular ATP. These methodologies involve (a) synthesis of alkyl-lysoPC containing 32P by a combination of enzymatic and chemical procedures and (b) incubation of HL-60 granulocytes with this alkyl-[32P] lysoPC which enters the cell and becomes acylated into membrane-associated alkyl-[32P]PC. Upon stimulation of these 32P-labeled cells with the chemotactic peptide, N-formyl-Met-Leu-Phe (fMLP), alkyl-[32P]phosphatidic acid (alkyl-[32P]PA) is formed rapidly. Because, under these conditions, cellular ATP has not been labeled with 32P, alkyl-[32P]PA must be formed via PLD-catalyzed hydrolysis of alkyl-[32P]PC at the terminal phosphodiester bond. This result conclusively demonstrates fMLP-induced activation of PLD in HL-60 granulocytes. These 32P-labeled HL-60 granulocytes have also been stimulated in the presence of ethanol to produce alkyl-[32P]phosphatidylethanol (alkyl-[32P]PEt). Formation of alkyl-[32P]PEt parallels that of alkyl-[32P]PA with respect to time course, fMLP concentration, inhibition by a specific fMLP antagonist (t-butoxycarbonyl-Met-Leu-Phe), and Ca2+ concentration

Constrained supermanifolds for AdS M-theory backgrounds

International Nuclear Information System (INIS)

Fre, Pietro; Grassi, Pietro Antonio

2008-01-01

A long standing problem is the supergauge completion of AdS 4 x ({G/H}) 7 or AdS 5 x ({G/H}) 5 backgrounds which preserve less then maximal supersymmetry. In parallel with the supersolvable realization of the AdS 4 x S 7 background based on κ-symmetry, we develop a technique which amounts to solving the above-mentioned problem in a way useful for pure spinor quantization for supermembranes and superstrings. Instead of gauge fixing some of the superspace coordinates using κ-symmetry, we impose an additional constraint on them reproducing the simplifications of the supersolvable representations. The constraints are quadratic, homogeneous, Sp(4,R)-covariant, and consistent from the quantum point of view in the pure spinor approach. Here we provide the geometrical solution which, in a subsequent work, will be applied to the membrane and the superstring sigma models

Characterization of plasma current quench during disruptions at HL-2A

Science.gov (United States)

Zhu, Jinxia; Zhang, Yipo; Dong, Yunbo; HL-2A Team

2017-05-01

The most essential assumptions of physics for the evaluation of electromagnetic forces on the plasma-facing components due to a disruption-induced eddy current are characteristics of plasma current quenches including the current quench rate or its waveforms. The characteristics of plasma current quenches at HL-2A have been analyzed during spontaneous disruptions. Both linear decay and exponential decay are found in the disruptions with the fastest current quenches. However, there are two stages of current quench in the slow current quench case. The first stage with an exponential decay and the second stage followed by a rapid linear decay. The faster current quench rate corresponds to the faster movement of plasma displacement. The parameter regimes on the current quench time and the current quench rates have been obtained from disruption statistics at HL-2A. There exists no remarkable difference for distributions obtained between the limiter and the divertor configuration. This data from HL-2A provides basic data of the derivation of design criteria for a large-sized machine during the current decay phase of the disruptions.

Radiation hard silicon particle detectors for HL-LHC—RD50 status report

Energy Technology Data Exchange (ETDEWEB)

Terzo, S., E-mail: Stefano.Terzo@mpp.mpg.de

2017-02-11

It is foreseen to significantly increase the luminosity of the LHC by upgrading towards the HL-LHC (High Luminosity LHC). The Phase-II-Upgrade scheduled for 2024 will mean unprecedented radiation levels, way beyond the limits of the silicon trackers currently employed. All-silicon central trackers are being studied in ATLAS, CMS and LHCb, with extremely radiation hard silicon sensors to be employed on the innermost layers. Within the RD50 Collaboration, a massive R&D program is underway across experimental boundaries to develop silicon sensors with sufficient radiation tolerance. We will present results of several detector technologies and silicon materials at radiation levels corresponding to HL-LHC fluences. Based on these results, we will give recommendations for the silicon detectors to be used at the different radii of tracking systems in the LHC detector upgrades. In order to complement the measurements, we also perform detailed simulation studies of the sensors. - Highlights: • The RD50 collaboration investigates the radiation hardness of silicon sensors. • Different approaches to simulate the detector response after irradiation are shown. • HV-CMOS are cost-effective solution for the outer pixel layers at HL-LHC. • 3D and thin planar sensors with slim edges are solutions for innermost layers at HL-LHC. • Sensors with intrinsic gain are investigated to develop ultra-fast silicon detectors.

Recent advances in the HL-2A tokamak experiments

International Nuclear Information System (INIS)

Liu, Y.; Ding, X.T.; Yang, Q.W.; Yan, L.W.; Liu, D.Q.; Xuan, W.M.; Chen, L.Y.; Song, X.M.; Cao, Z.; Zhang, J.H.; Mao, W.C.; Zhou, C.P.; Li, X.D.; Wang, S.J.; Yan, J.C.; Bu, M.N.; Chen, Y.H.; Cui, C.H.; Cui, Z.Y.; Deng, Z.C.; Hong, W.Y.; Hu, H.T.; Huang, Y.; Kang, Z.H.; Li, B.; Li, W.; Li, F.Z.; Li, G.S.; Li, H.J.; Li, Q.; Li, Y.G.; Li, Z.J.; Liu, Yi; Liu, Z.T.; Luo, C.W.; Mao, X.H.; Pan, Y.D.; Rao, J.; Shao, K.; Song, X.Y.; Wang, M.; Wang, M.X.; Wang, Q.M.; Xiao, Z.G.; Xie, Y.F.; Yao, L.H.; Yao, L.Y.; Zheng, Y.J.; Zhong, G.W.; Zhou, Y.; Pan, C.H.

2005-01-01

Two experiment campaigns were conducted on the HL-2A tokamak in 2003 and 2004 after the first plasma was obtained at the end of 2002. Progresses in many aspects have been made, especially in the divertor discharge and feedback control of plasma configuration. Up to now, the following operation parameters have been achieved: I p = 320 kA, B t = 2.2 T and discharge duration T d = 1580 ms. With the feedback control of plasma current and horizontal position, an excellent repeatability of the discharge has been achieved. The tokamak has been operated at both limiter configuration and single null (SN) divertor configuration. The HL-2A SN divertor configuration is simulated with the MHD equilibrium code SWEQU. When the divertor configuration is formed, the impurity radiation in the main plasma decreases remarkably

Magnetically Induced Disk Winds and Transport in the HL Tau Disk

International Nuclear Information System (INIS)

Hasegawa, Yasuhiro; Flock, Mario; Turner, Neal J.; Okuzumi, Satoshi

2017-01-01

The mechanism of angular momentum transport in protoplanetary disks is fundamental to understanding the distributions of gas and dust in the disks. The unprecedented ALMA observations taken toward HL Tau at high spatial resolution and subsequent radiative transfer modeling reveal that a high degree of dust settling is currently achieved in the outer part of the HL Tau disk. Previous observations, however, suggest a high disk accretion rate onto the central star. This configuration is not necessarily intuitive in the framework of the conventional viscous disk model, since efficient accretion generally requires a high level of turbulence, which can suppress dust settling considerably. We develop a simplified, semi-analytical disk model to examine under what condition these two properties can be realized in a single model. Recent, non-ideal MHD simulations are utilized to realistically model the angular momentum transport both radially via MHD turbulence and vertically via magnetically induced disk winds. We find that the HL Tau disk configuration can be reproduced well when disk winds are properly taken into account. While the resulting disk properties are likely consistent with other observational results, such an ideal situation can be established only if the plasma β at the disk midplane is β 0 ≃ 2 × 10 4 under the assumption of steady accretion. Equivalently, the vertical magnetic flux at 100 au is about 0.2 mG. More detailed modeling is needed to fully identify the origin of the disk accretion and quantitatively examine plausible mechanisms behind the observed gap structures in the HL Tau disk.

Magnetically Induced Disk Winds and Transport in the HL Tau Disk

Energy Technology Data Exchange (ETDEWEB)

Hasegawa, Yasuhiro; Flock, Mario; Turner, Neal J. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Okuzumi, Satoshi, E-mail: yasuhiro@caltech.edu [Department of Earth and Planetary Sciences, Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8551 (Japan)

2017-08-10

The mechanism of angular momentum transport in protoplanetary disks is fundamental to understanding the distributions of gas and dust in the disks. The unprecedented ALMA observations taken toward HL Tau at high spatial resolution and subsequent radiative transfer modeling reveal that a high degree of dust settling is currently achieved in the outer part of the HL Tau disk. Previous observations, however, suggest a high disk accretion rate onto the central star. This configuration is not necessarily intuitive in the framework of the conventional viscous disk model, since efficient accretion generally requires a high level of turbulence, which can suppress dust settling considerably. We develop a simplified, semi-analytical disk model to examine under what condition these two properties can be realized in a single model. Recent, non-ideal MHD simulations are utilized to realistically model the angular momentum transport both radially via MHD turbulence and vertically via magnetically induced disk winds. We find that the HL Tau disk configuration can be reproduced well when disk winds are properly taken into account. While the resulting disk properties are likely consistent with other observational results, such an ideal situation can be established only if the plasma β at the disk midplane is β {sub 0} ≃ 2 × 10{sup 4} under the assumption of steady accretion. Equivalently, the vertical magnetic flux at 100 au is about 0.2 mG. More detailed modeling is needed to fully identify the origin of the disk accretion and quantitatively examine plausible mechanisms behind the observed gap structures in the HL Tau disk.

Iron nanoparticles increase 7-ketocholesterol-induced cell death, inflammation, and oxidation on murine cardiac HL1-NB cells

Directory of Open Access Journals (Sweden)

Edmond Kahn

2010-03-01

Full Text Available Edmond Kahn1, Mauhamad Baarine2, Sophie Pelloux3, Jean-Marc Riedinger4, Frédérique Frouin1, Yves Tourneur3, Gérard Lizard21INSE RM U678/UMR – S UPMC, IFR 14, CH U Pitié-Salpêtrière, 75634 Paris Cedex 13, France; 2Centre de Recherche INSE RM U866, Equipe Biochimie Métabolique et Nutritionnelle – Université de Bourgogne, Faculté des Sciences Gabriel, 6 Bd Gabriel, 21000 Dijon, France; 3Centre Commun de Quantimétrie, Université Lyon 1; Université de Lyon, Lyon, France; 4Département de Biologie et de Pathologie des Tumeurs, Centre Georges François-Leclerc, 21000 Dijon, FranceObjective: To evaluate the cytotoxicity of iron nanoparticles on cardiac cells and to determine whether they can modulate the biological activity of 7-ketocholesterol (7KC involved in the development of cardiovascular diseases. Nanoparticles of iron labeled with Texas Red are introduced in cultures of nonbeating mouse cardiac cells (HL1-NB with or without 7-ketocholesterol 7KC, and their ability to induce cell death, pro-inflammatory and oxidative effects are analyzed simultaneously.Study design: Flow cytometry (FCM, confocal laser scanning microscopy (CLSM, and subsequent factor analysis image processing (FAMIS are used to characterize the action of iron nanoparticles and to define their cytotoxicity which is evaluated by enhanced permeability to SYTOX Green, and release of lactate deshydrogenase (LDH. Pro-inflammatory effects are estimated by ELISA in order to quantify IL-8 and MCP-1 secretions. Pro-oxidative effects are measured with hydroethydine (HE.Results: Iron Texas Red nanoparticles accumulate at the cytoplasmic membrane level. They induce a slight LDH release, and have no inflammatory or oxidative effects. However, they enhance the cytotoxic, pro-inflammatory and oxidative effects of 7KC. The accumulation dynamics of SYTOX Green in cells is measured by CLSM to characterize the toxicity of nanoparticles. The emission spectra of SYTOX Green and

High spatial and temporal resolution charge exchange recombination spectroscopy on the HL-2A tokamak

Energy Technology Data Exchange (ETDEWEB)

Wei, Y. L.; Yu, D. L., E-mail: yudl@swip.ac.cn; Liu, L.; Cao, J. Y.; Sun, A. P.; Ma, Q.; Chen, W. J.; Liu, Yi; Yan, L. W.; Yang, Q. W.; Duan, X. R.; Liu, Yong [Southwestern Institute of Physics, Chengdu 610041 (China); Ida, K. [National Institute for Fusion Science, Toki 509-5292 (Japan); Hellermann, M. von [ITER Diagnostic Team, IO, Route de Vinon sur Verdon, 13115 St Paul lez Durance (France); FOM-Institute for Plasma physics “Rijnhuizen,” Association EURATOM, Trilateral Euregio Cluster, 3430 BE Nieuwegein (Netherlands)

2014-10-01

A 32/64-channel charge exchange recombination spectroscopy (CXRS) diagnostic system is developed on the HL-2A tokamak (R = 1.65 m, a = 0.4 m), monitoring plasma ion temperature and toroidal rotation velocity simultaneously. A high throughput spectrometer (F/2.8) and a pitch-controlled fiber bundle enable the temporal resolution of the system up to 400 Hz. The observation geometry and an optimized optic system enable the highest radial resolution up to ~1 cm at the plasma edge. The CXRS system monitors the carbon line emission (C VI, n = 8–7, 529.06 nm) whose Doppler broadening and Doppler shift provide ion temperature and plasma rotation velocity during the neutral beam injection. The composite CX spectral data are analyzed by the atomic data and analysis structure charge exchange spectroscopy fitting (ADAS CXSFIT) code. First experimental results are shown for the case of HL-2A plasmas with sawtooth oscillations, electron cyclotron resonance heating, and edge transport barrier during the high-confinement mode (H-mode)

The CMS HGCAL detector for HL-LHC upgrade

CERN Document Server

Martelli, Arabella

2017-01-01

The High Luminosity LHC (HL-LHC) will integrate 10 times more luminosity than the LHC, posing significant challenges for radiation tolerance and event pileup on detectors, especially for forward calorimetry, and hallmarks the issue for future colliders. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (ECAL) and hadronic (HCAL) compartments. This will facilitate particle-flow calorimetry, where the fine structure of showers can be measured and used to enhance pileup rejection and particle identification, whilst still achieving good energy resolution. The ECAL and a large fraction of HCAL will be based on hexagonal silicon sensors of 0.5 - 1 cm$^2$ cell size, with the remainder of the HCAL based on highly-segmented scintillators with SiPM readout. The intrinsic high-precision timing capabilities of the silicon sensors wi...

The CMS High Granularity Calorimeter for HL-LHC

CERN Document Server

Mastrolorenzo, Luca

2017-01-01

The High Luminosity LHC (HL-LHC) will integrate 10 times more luminosity than the LHC, posing significant challenges for radiation tolerance and event pileup on detectors, especially for forward calorimetry, and hallmarks the issue for future colliders. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (ECAL) and hadronic (HCAL) compartments. This will facilitate particle-flow calorimetry, where the fine structure of showers can be measured and used to enhance pileup rejection and particle identification, whilst still achieving good energy resolution. The ECAL and a large fraction of HCAL will be based on hexagonal silicon sensors of 0.5 - 1 cm$^2$ cell size, with the remainder of the HCAL based on highly-segmented scintillators with SiPM readout. The intrinsic high-precision timing capabilities of the silicon sensors wi...

Cdc6 is a rate-limiting factor for proliferative capacity during HL60 cell differentiation

International Nuclear Information System (INIS)

Barkley, Laura R.; Hong, Hye Kyung; Kingsbury, Sarah R.; James, Michelle; Stoeber, Kai; Williams, Gareth H.

2007-01-01

The DNA replication (or origin) licensing pathway represents a critical step in cell proliferation control downstream of growth signalling pathways. Repression of origin licensing through down-regulation of the MCM licensing factors (Mcm2-7) is emerging as a ubiquitous route for lowering proliferative capacity as metazoan cells exit the cell division cycle into quiescent, terminally differentiated and senescent 'out-of-cycle' states. Using the HL60 monocyte/macrophage differentiation model system and a cell-free DNA replication assay, we have undertaken direct biochemical investigations of the coupling of origin licensing to the differentiation process. Our data show that down-regulation of the MCM loading factor Cdc6 acts as a molecular switch that triggers loss of proliferative capacity during early engagement of the somatic differentiation programme. Consequently, addition of recombinant Cdc6 protein to in vitro replication reactions restores DNA replication competence in nuclei prepared from differentiating cells. Differentiating HL60 cells over-expressing either wild-type Cdc6 or a CDK phosphorylation-resistant Cdc6 mutant protein (Cdc6A4) exhibit an extended period of cell proliferation compared to mock-infected cells. Notably, differentiating HL60 cells over-expressing the Cdc6A4 mutant fail to down-regulate Cdc6 protein levels, suggesting that CDK phosphorylation of Cdc6 is linked to its down-regulation during differentiation and the concomitant decrease in cell proliferation. In this experimental model, Cdc6 therefore plays a key role in the sequential molecular events leading to repression of origin licensing and loss of proliferative capacity during execution of the differentiation programme

Power supply for plasma generator of HL-1M neutral beam injector

International Nuclear Information System (INIS)

Wang Detai; Qian Jiamei; Lei Guangjiu; Shun Mengda; Jiang Shaofeng; Wang Enyao; Lu Xuejun; Yang Tiehai; Wang Xuehua; Zhao Zhimin; Hao Ming; Huang Jianrong; Yu Yanqiu; Cheng Baoqiang; Wu Zhige; Sheng Ning; Hu Qingtao

1999-01-01

The diagram of the HL-1M Neutral Beam Injector (NBI) and the power supply (PS) system is shown. The NBI consists of ion source, beam line and power supply system etc. The ion source includes plasma generator and three-electrode extraction system. The power supply for plasma generator consists of a filament PS, an arc PS and gas valve PS. Testing has shown that the PS for plasma generator of the HL-1M NBI has excellent stability and obtain good plasma heating effect

Incremental testing of the Community Multiscale Air Quality (CMAQ modeling system version 4.7

Directory of Open Access Journals (Sweden)

K. M. Foley

2010-03-01

Full Text Available This paper describes the scientific and structural updates to the latest release of the Community Multiscale Air Quality (CMAQ modeling system version 4.7 (v4.7 and points the reader to additional resources for further details. The model updates were evaluated relative to observations and results from previous model versions in a series of simulations conducted to incrementally assess the effect of each change. The focus of this paper is on five major scientific upgrades: (a updates to the heterogeneous N₂O₅ parameterization, (b improvement in the treatment of secondary organic aerosol (SOA, (c inclusion of dynamic mass transfer for coarse-mode aerosol, (d revisions to the cloud model, and (e new options for the calculation of photolysis rates. Incremental test simulations over the eastern United States during January and August 2006 are evaluated to assess the model response to each scientific improvement, providing explanations of differences in results between v4.7 and previously released CMAQ model versions. Particulate sulfate predictions are improved across all monitoring networks during both seasons due to cloud module updates. Numerous updates to the SOA module improve the simulation of seasonal variability and decrease the bias in organic carbon predictions at urban sites in the winter. Bias in the total mass of fine particulate matter (PM_2.5 is dominated by overpredictions of unspeciated PM_2.5 (PM_other in the winter and by underpredictions of carbon in the summer. The CMAQv4.7 model results show slightly worse performance for ozone predictions. However, changes to the meteorological inputs are found to have a much greater impact on ozone predictions compared to changes to the CMAQ modules described here. Model updates had little effect on existing biases in wet deposition predictions.

An investigation of AdS2 backreaction and holography

International Nuclear Information System (INIS)

Engelsöy, Julius; Mertens, Thomas G.; Verlinde, Herman

2016-01-01

We investigate a dilaton gravity model in AdS 2 proposed by Almheiri and Polchinski http://dx.doi.org/10.1007/JHEP11(2015)014 and develop a 1d effective description in terms of a dynamical boundary time with a Schwarzian derivative action. We show that the effective model is equivalent to a 1d version of Liouville theory, and investigate its dynamics and symmetries via a standard canonical framework. We include the coupling to arbitrary conformal matter and analyze the effective action in the presence of possible sources. We compute commutators of local operators at large time separation, and match the result with the time shift due to a gravitational shockwave interaction. We study a black hole evaporation process and comment on the role of entropy in this model.

Use of hypoxia imaging agent 99mTc-HL91 in rat cerebral ischemia models

International Nuclear Information System (INIS)

Zhou Ying; Qu Wanying; Li Meng; Chen Fang; Yao Zhiming; Zhu Ming; Zhu Lin

1999-01-01

Objective: To explore the possibility of diagnosis for cerebrovascular disease by a novel synthetic hypoxia agent 99m Tc-HL91 used in rat cerebral ischemia models. Methods: Pharmacological experiments of 99m Tc-HL91 were carried out including common properties, radiochemical purity, stability in vitro, anomalous toxicity test and biodistribution in mice. Fifteen cerebral ischemic rat models were established and received 99m Tc-HL91 scintigraphy. Results: 1) HL91 kits were labelled with 99m Tc easily and showed high radiochemical purity and stability. 2) Rapid clearance in blood, heart and lungs and high activity in liver, kidneys and intestines were observed. Relatively low uptake in brain was identified. 3) The radioactivity in ischemic brain tissue increased significantly at 4h postinjection in both rat images and isolated brain images. 4) The radioactivity ratios of lesion to normal brain tissue by drawing ROIs in isolated brain planar images were 0.98 +- 0.06, 0.99 +- 0.05, 1.29 +- 0.03, 1.56 +- 0.14 and 1.66 +- 0.06 at 1,2,4,8 and 12 h postinjection, respectively. There were significant differences among all groups except for 1 h and 2 h, 8 h and 12 h postinjection (P 99m Tc-HL91 in the hypoxic, ischemic brain tissue have been proved. It is appropriate to perform imaging at 4 h postinjection

The Gaia Framework: Version Support In Web Based Open Hypermedia

DEFF Research Database (Denmark)

Grønbæk, Kaj; Kejser, Thomas

2004-01-01

The GAIA framework prototype, described herein, explores the possibilities and problems that arise when combining versioning and open hypermedia paradigms. It will be argued that it - by adding versioning as a separate service in the hypermedia architecture – is possible to build consistent...... versioning field and GAIA is compared with previous attempts at defining hypermedia versioning frameworks. GAIA is capable of multi-level versioning and versioning of structures and supports freezing mechanisms for both documents and hyperstructure. The experiences from GAIA provide an input to new reference...

The Gaia Framework: Version Support In Web Based Open Hypermedia

DEFF Research Database (Denmark)

Kejser, Thomas; Grønbæk, Kaj

2003-01-01

The GAIA framework prototype, described herein, explores the possibilities and problems that arise when combining versioning and open hypermedia paradigms. It will be argued that it - by adding versioning as a separate service in the hypermedia architecture - is possible to build consistent...... versioning field and GAIA is compared with previous attempts at defining hypermedia versioning frameworks. GAIA is capable of multi-level versioning and versioning of structures and supports freezing mechanisms for both documents and hyperstructure. The experiences from GAIA provide an input to new reference...

Hollow Electron Beam Collimation for HL-LHC - Effects on the Beam Core

Energy Technology Data Exchange (ETDEWEB)

Fitterer, M. [Fermilab; Stancari, G. [Fermilab; Valishev, A. [Fermilab; Bruce, R. [CERN; Papotti, G [CERN; Redaelli, S. [CERN; Valentino, G. [Malta U.; Valentino, G. [CERN; Valuch, D. [CERN; Xu, C. [CERN

2017-06-13

Collimation with hollow electron beams is currently one of the most promising concepts for active halo control in the High Luminosity Large Hadron Collider (HL-LHC). To ensure the successful operation of the hollow beam collimator the unwanted effects on the beam core, which might arise from the operation with a pulsed electron beam, must be minimized. This paper gives a summary of the effect of hollow electron lenses on the beam core in terms of sources, provides estimates for HL-LHC and discusses the possible mitigation methods.

Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships.

Science.gov (United States)

Okubo, Shinya; Uto, Takuhiro; Goto, Aya; Tanaka, Hiroyuki; Nishioku, Tsuyoshi; Yamada, Katsushi; Shoyama, Yukihiro

2017-01-01

Berberine (BBR), an isoquinoline alkaloid, is a well-known bioactive compound contained in medicinal plants used in traditional and folk medicines. In this study, we investigated the subcellular localization and the apoptotic mechanisms of BBR were elucidated. First, we confirmed the incorporation of BBR into the cell visually. BBR showed antiproliferative activity and promptly localized to the nucleus from 5[Formula: see text]min to 15[Formula: see text]min after BBR treatment in HL-60 human promyelocytic leukemia cells. Next, we examined the antiproliferative activity of BBR (1) and its biosynthetically related compounds (2-7) in HL-60 cells. BBR exerted strongest antiproliferative activity among 1-7 and the results of structures and activity relation suggested that a methylenedioxyl group in ring A, an [Formula: see text]-alkyl group at C-9 position, and the frame of isoquinoline may be necessary for antiproliferative activity. Moreover, BBR showed the most potent antiproliferative activity in HL-60 cells among human cancer and normal cell lines tested. Next, we examined the effect of BBR on molecular events known as apoptosis induction. In HL-60 cells, BBR induced chromatin condensation and DNA fragmentation, and triggered the activation of PARP, caspase-3 and caspase-8 without the activation of caspase-9. BBR-induced DNA fragmentation was abolished by pretreatment with inhibitors against caspase-3 and caspase-8, but not against caspase-9. ERK and p38 were promptly phosphorylated after 15 min of BBR treatment, and this was correlated with time of localization to the nucleus of BBR. These results demonstrated that BBR translocated into nucleus immediately after treatments and induced apoptotic cell death by activation of caspase-3 and caspase-8.

Reflexe ČAVU v české společnosti na příkladu vztahu Julia Zeyera a Josefa Hlávky

Czech Academy of Sciences Publication Activity Database

Pokorná, Magdaléna

2015-01-01

Roč. 7, č. 1 (2015), s. 19-28 ISSN 1803-9448 Institutional research plan: CEZ:AV0Z8015903 Institutional support: RVO:67985963 Keywords : Czech history * Czech Academy of Sciences and Arts * Josef Hlávka * Julius Zeyer Subject RIV: AB - History

H-L transition caused by irregular probe insertion in the JFT-2M tokamak

International Nuclear Information System (INIS)

Hanada, K.; Hasegawa, M.; Shinohara, K.

1996-01-01

A pair of probe pins whose lengths differ by 5 mm are inserted into the separatrix of H-mode plasmas. When the long pin is biased positively against the short one, the H-L transition takes place and the current through the resistor making a connection between these pins increases for 10 μs and the potential of the pin increases for 100 μs. The energy dissipated by the resistor during the H-L transition is comparable to the energy of the radial electric field in H-mode plasma. When the long pin is biased negatively, the H-L transition also occurs; however, it takes 1 ms to change the potential of the pin and the plasma returns to H-mode after the extraction of the probe. (author)

[Biologically active fragment of the differentiation factor from HL-60 cell line. Identification and properties].

Science.gov (United States)

Kostanian, I A; Astapova, M V; Navolotskaia, E V; Lepikhova, T N; Dranitsyna, S M; Telegin, G B; Rodionov, I L; Baĭdakova, L K; Zolotarev, Iu A; Molotkovskaia, I M; Lipkin, V M

2000-07-01

Six-membered peptide fragment TGENHR (HLDF-6) was identified in the HL-60 cell culture of human promyelocyte leukemia treated with retinoic acid when studying the differentiation factor HLDF of this cell line. HLDF-6 retains the ability of the full-size factor to induce the differentiation and arrest the proliferation of the starting HL-60 cells. It was shown that the synthetic peptide HLDF-6 has no specific receptors on the surface of the HL-60 cells but can affect the binding of interleukin IL-1 beta, a cytokine involved in proliferation, to the cell surface. It was found on a model of transplantable NSO myeloma that HLDF-6 has an antitumor activity.

Verification of RESRAD-RDD. (Version 2.01)

Energy Technology Data Exchange (ETDEWEB)

Cheng, Jing-Jy [Argonne National Lab. (ANL), Argonne, IL (United States); Flood, Paul E. [Argonne National Lab. (ANL), Argonne, IL (United States); LePoire, David [Argonne National Lab. (ANL), Argonne, IL (United States); Kamboj, Sunita [Argonne National Lab. (ANL), Argonne, IL (United States); Yu, Charley [Argonne National Lab. (ANL), Argonne, IL (United States)

2015-09-01

In this report, the results generated by RESRAD-RDD version 2.01 are compared with those produced by RESRAD-RDD version 1.7 for different scenarios with different sets of input parameters. RESRAD-RDD version 1.7 is spreadsheet-driven, performing calculations with Microsoft Excel spreadsheets. RESRAD-RDD version 2.01 revamped version 1.7 by using command-driven programs designed with Visual Basic.NET to direct calculations with data saved in Microsoft Access database, and re-facing the graphical user interface (GUI) to provide more flexibility and choices in guideline derivation. Because version 1.7 and version 2.01 perform the same calculations, the comparison of their results serves as verification of both versions. The verification covered calculation results for 11 radionuclides included in both versions: Am-241, Cf-252, Cm-244, Co-60, Cs-137, Ir-192, Po-210, Pu-238, Pu-239, Ra-226, and Sr-90. At first, all nuclidespecific data used in both versions were compared to ensure that they are identical. Then generic operational guidelines and measurement-based radiation doses or stay times associated with a specific operational guideline group were calculated with both versions using different sets of input parameters, and the results obtained with the same set of input parameters were compared. A total of 12 sets of input parameters were used for the verification, and the comparison was performed for each operational guideline group, from A to G, sequentially. The verification shows that RESRAD-RDD version 1.7 and RESRAD-RDD version 2.01 generate almost identical results; the slight differences could be attributed to differences in numerical precision with Microsoft Excel and Visual Basic.NET. RESRAD-RDD version 2.01 allows the selection of different units for use in reporting calculation results. The results of SI units were obtained and compared with the base results (in traditional units) used for comparison with version 1.7. The comparison shows that RESRAD

The ohmic heating power supply for HL-1 tokamak

International Nuclear Information System (INIS)

Mingrui, Z.; Jiashun, C.

1986-01-01

A combination of capacitor banks, inductor and DC Fly wheel-Generator sets are used as ohmic heating power supply (OHPS) for HL-1, which is the largest tokamak in China. This system can give changeable waveform of current in a simple way, because of the use of protection for capacitor banks by changeable connection in easy way. Since the technology of forced zero current in the commutating breaker and synchronous self-triggering crowbar are used, the smooth conversion between the wave front provided by discharge of the capacitor banks and the flat top sustained by the inductor and flywheel realized. The performance of the system was tested by a dummy load and the system has been used in the HL-1 experiments. It is confirmed that this system is sufficiently available for the ohmic heating and has important effects on the long plasma lasting time on the order of 1 sec

The CMS ECAL Upgrade for Precision Crystal Calorimetry at the HL-LHC

CERN Document Server

Marinelli, Nancy

2017-01-01

The Compact Muon Solenoid Experiment (CMS) is operating at the Large Hadron Collider (LHC) with proton-proton collisions at 13 TeV center-of-mass energy and at a bunch spacing of 25 ns. New further challenging running conditions for CMS are expected after the High-Luminosity upgrade of the LHC (HL--LHC). The CMS electromagnetic calorimeter (ECAL) will need to be upgraded to substain the hardned environment.The design and R\\ and D studies for the ECAL upgrade are presented together with first test beam studies. Particular challenges at HL--LHC are the harsh radiation environment, the increasing data rates and the extreme level of pile-up events, with up to 200 simultaneous proton-proton collisions. Precision timing can be exploited to reduce the effect of the pile-up. Time resolution measurementscarried out during test-beams are shown. Plans are also shown for R\\ and D for the new readout and trigger electronics, which must be upgraded due to the increased trigger and latency requirements at the HL--LHC

THE VLA VIEW OF THE HL TAU DISK: DISK MASS, GRAIN EVOLUTION, AND EARLY PLANET FORMATION

Energy Technology Data Exchange (ETDEWEB)

Carrasco-González, Carlos; Rodríguez, Luis F.; Galván-Madrid, Roberto [Instituto de Radioastronomía y Astrofísica UNAM, Apartado Postal 3-72 (Xangari), 58089 Morelia, Michoacán, México (Mexico); Henning, Thomas; Linz, Hendrik; Birnstiel, Til; Boekel, Roy van; Klahr, Hubert [Max-Planck-Institut für Astronomie Heidelberg, Königstuhl 17, D-69117 Heidelberg (Germany); Chandler, Claire J.; Pérez, Laura [National Radio Astronomy Observatory, P.O. Box O, 1003 Lopezville Road, Socorro, NM 87801-0387 (United States); Anglada, Guillem; Macias, Enrique; Osorio, Mayra [Instituto de Astrofísica de Andalucía (CSIC), Apartado 3004, E-18080 Granada (Spain); Flock, Mario [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Menten, Karl [Jansky Fellow of the National Radio Astronomy Observatory (United States); Testi, Leonardo [European Southern Observatory, Karl-Schwarzschild-Str. 2, D-85748 Garching bei München (Germany); Torrelles, José M. [Institut de Ciències de l’Espai (CSIC-IEEC) and Institut de Ciències del Cosmos (UB-IEEC), Martí i Franquès 1, E-08028 Barcelona (Spain); Zhu, Zhaohuan, E-mail: c.carrasco@crya.unam.mx, E-mail: l.rodriguez@crya.unam.mx, E-mail: r.galvan@crya.unam.mx, E-mail: henning@mpia.de, E-mail: linz@mpia.de [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States)

2016-04-10

The first long-baseline ALMA campaign resolved the disk around the young star HL Tau into a number of axisymmetric bright and dark rings. Despite the very young age of HL Tau, these structures have been interpreted as signatures for the presence of (proto)planets. The ALMA images triggered numerous theoretical studies based on disk–planet interactions, magnetically driven disk structures, and grain evolution. Of special interest are the inner parts of disks, where terrestrial planets are expected to form. However, the emission from these regions in HL Tau turned out to be optically thick at all ALMA wavelengths, preventing the derivation of surface density profiles and grain-size distributions. Here, we present the most sensitive images of HL Tau obtained to date with the Karl G. Jansky Very Large Array at 7.0 mm wavelength with a spatial resolution comparable to the ALMA images. At this long wavelength, the dust emission from HL Tau is optically thin, allowing a comprehensive study of the inner disk. We obtain a total disk dust mass of (1–3) × 10{sup −3} M {sub ⊙}, depending on the assumed opacity and disk temperature. Our optically thin data also indicate fast grain growth, fragmentation, and formation of dense clumps in the inner densest parts of the disk. Our results suggest that the HL Tau disk may be actually in a very early stage of planetary formation, with planets not already formed in the gaps but in the process of future formation in the bright rings.

THE VLA VIEW OF THE HL TAU DISK: DISK MASS, GRAIN EVOLUTION, AND EARLY PLANET FORMATION

International Nuclear Information System (INIS)

Carrasco-González, Carlos; Rodríguez, Luis F.; Galván-Madrid, Roberto; Henning, Thomas; Linz, Hendrik; Birnstiel, Til; Boekel, Roy van; Klahr, Hubert; Chandler, Claire J.; Pérez, Laura; Anglada, Guillem; Macias, Enrique; Osorio, Mayra; Flock, Mario; Menten, Karl; Testi, Leonardo; Torrelles, José M.; Zhu, Zhaohuan

2016-01-01

The first long-baseline ALMA campaign resolved the disk around the young star HL Tau into a number of axisymmetric bright and dark rings. Despite the very young age of HL Tau, these structures have been interpreted as signatures for the presence of (proto)planets. The ALMA images triggered numerous theoretical studies based on disk–planet interactions, magnetically driven disk structures, and grain evolution. Of special interest are the inner parts of disks, where terrestrial planets are expected to form. However, the emission from these regions in HL Tau turned out to be optically thick at all ALMA wavelengths, preventing the derivation of surface density profiles and grain-size distributions. Here, we present the most sensitive images of HL Tau obtained to date with the Karl G. Jansky Very Large Array at 7.0 mm wavelength with a spatial resolution comparable to the ALMA images. At this long wavelength, the dust emission from HL Tau is optically thin, allowing a comprehensive study of the inner disk. We obtain a total disk dust mass of (1–3) × 10 −3 M ⊙ , depending on the assumed opacity and disk temperature. Our optically thin data also indicate fast grain growth, fragmentation, and formation of dense clumps in the inner densest parts of the disk. Our results suggest that the HL Tau disk may be actually in a very early stage of planetary formation, with planets not already formed in the gaps but in the process of future formation in the bright rings

Instrumentation for silicon tracking at the HL-LHC

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00524651; Strandberg, Sara; Garcia-Sciveres, Maurice

2017-06-14

In 2027 the Large Hadron Collider (LHC) at CERN will enter a high luminosity phase, deliver- ing 3000 fb 1 over the course of ten years. The High Luminosity LHC (HL-LHC) will increase the instantaneous luminosity delivered by a factor of 5 compared to the current operation pe- riod. This will impose significant technical challenges on all aspects of the ATLAS detector but particularly the Inner Detector, trigger, and data acquisition systems. In addition, many of the components of the Inner Detector are reaching the end of their designed lifetime and will need to be exchanged. As such, the Inner Detector will be entirely replaced by an all silicon tracker, known as the Inner Tracker (ITk). The layout of the Pixel and strip detectors will be optimised for the upgrade and will extend their forward coverage. To reduce the per-pixel hit rate and explore novel techniques for deal- ing with the conditions in HL-LHC, an inter-experiment collaboration called RD53 has been formed. RD53 is tasked with producing a front...

The synthesis of phosphatidylalcohols in HL-60 cells

International Nuclear Information System (INIS)

Tettenborn, C.S.

1988-01-01

This study focuses upon the phenomenon that 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulates a pathway for the synthesis of phosphatidylalcohols in HL-60 cells during the differentiation of these cells to macrophages. Using exogenous ethanol as a substrate for this pathway, the synthesis of phosphatidylethanol is induced by TPA well before full expression of differentiation. Experiments done in whole cell cultures demonstrated that this pathway could utilize a wide range of other alcohols as substrates, including glycerol, a potential endogenous substrate. Using radiolabeling and iodine-staining as criteria, this TPA-inducible pathway was shown to result in a dramatic alteration of phospholipid composition, depending on the availability of the alcohol headgroup. A cell-free system was developed to explore the enzymatic reactions involved in phosphatidylalcohol synthesis, a main goal of these studies. For this purpose, the lipid pools of HL-60 cells were prelabeled with [ 3 H]arachidonic acid in the absence of ethanol and total cell homogenates were prepared by sonication. The ability of the cell lysates to synthesize phosphatidylethanol was assayed after addition of ethanol to the system

The ATLAS tracker strip detector for HL-LHC

CERN Document Server

Cormier, Kyle James Read; The ATLAS collaboration

2016-01-01

As part of the ATLAS upgrades for the High Luminsotiy LHC (HL-LHC) the current ATLAS Inner Detector (ID) will be replaced by a new Inner Tracker (ITk). The ITk will consist of two main components: semi-conductor pixels at the innermost radii, and silicon strips covering larger radii out as far as the ATLAS solenoid magnet including the volume currently occupied by the ATLAS Transition Radiation Tracker (TRT). The primary challenges faced by the ITk are the higher planned read out rate of ATLAS, the high density of charged particles in HL-LHC conditions for which tracks need to be resolved, and the corresponding high radiation doses that the detector and electronics will receive. The ITk strips community is currently working on designing and testing all aspects of the sensors, readout, mechanics, cooling and integration to meet these goals and a Technical Design Report is being prepared. This talk is an overview of the strip detector component of the ITk, highlighting the current status and the road ahead.

The ATLAS tracker strip detector for HL-LHC

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00512833; The ATLAS collaboration

2017-01-01

As part of the ATLAS upgrades for the High Luminsotiy LHC (HL-LHC) the current ATLAS Inner Detector (ID) will be replaced by a new Inner Tracker (ITk). The ITk will consist of two main components: semi-conductor pixels at the innermost radii, and silicon strips covering larger radii out as far as the ATLAS solenoid magnet including the volume currently occupied by the ATLAS Transition Radiation Tracker (TRT). The primary challenges faced by the ITk are the higher planned read out rate of ATLAS, the high density of charged particles in HL-LHC conditions for which tracks need to be resolved, and the corresponding high radiation doses that the detector and electronics will receive. The ITk strips community is currently working on designing and testing all aspects of the sensors, readout, mechanics, cooling and integration to meet these goals and a Technical Design Report is being prepared. This talk is an overview of the strip detector component of the ITk, highlighting the current status and the road ahead.

Heat dissipation research on the water-cooling channel of HL-2M in-vessel coils

Energy Technology Data Exchange (ETDEWEB)

Jiang, J., E-mail: jiangjiaming@swip.ac.cn; Liu, Y.; Chen, Q.; Ji, X.Q.

2017-04-15

Highlights: • The joule heat of in-vessel coils is very difficult to dissipate inside HL-2M vacuum vessel. • Heat dissipation model of the coil includes the joule heat model, the heat conduction model and the heat transfer model. • The CFD analysis has been done for the coil-water cooling, with comparison with the date of theoretical analysis and experiment. • The result shows water-cooling channel is good for the joule heat transfer and taken away. - Abstract: HL-2M in-vessel coils are positioned in high vacuum circumstance, and they will generate joule heat when they carry 15 kA electrical current, but joule heat is very difficult to dissipate in vacuum, so a hollow cable with 8 mm inner diameter is design as water-cooling channel for heat convection. By using the methods of the theoretical derivation, together with CFD numeric simulation method and the experiment of the heat transfer, the water channel of HL-2M in-vessel coils has been studied, and the temperature of HL-2M in-vessel coils under different cooling water flow rates is obtained and acceptable. Simultaneously, the external cooling water supply system parameters for the water-cooling channel of the coils are estimated. Three methods’ results are in good agreement; the theoretical model is verified and could be popularized for predicting the temperature rise of HL-2M in-vessel coils.

NOAA Climate Data Record (CDR) of SSM/I and SSMIS Microwave Brightness Temperatures, RSS Version 7

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This Version 7 NOAA Fundamental Climate Data Record (CDR) from Remote Sensing Systems (RSS) contains brightness temperatures that have been inter-calibrated and...

Construction and beam-tests of silicon-tungsten and scintillator-SiPM modules for the CMS High Granularity Calorimeter for HL-LHC

CERN Document Server

Chang, Yung-wei

2018-01-01

A High Granularity Calorimeter (HGCAL) is being designed to replace the existing endcap calorimeters in CMS for the HL-LHC era. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (ECAL) and hadronic (HCAL) compartments, with silicon sensors being chosen for the high-pseudorapidity regions due to their radiation tolerance. The remainder of the HGCAL, in the lower radiation environment, will use plastic scintillator with on-tile SiPM readout. Prototype hexagonal silicon modules, featuring a new Skiroc2-CMS front-end chip, together with a modified version of the scintillator-SiPM CALICE AHCAL, have been built and tested in beams at CERN in 2017. In this poster, we present measurements of noise, calibration, shower shapes and performance with electrons, pions and muons.

Almost abelian twists and AdS/CFT

Directory of Open Access Journals (Sweden)

Stijn J. van Tongeren

2017-02-01

Full Text Available A large class of the recently found unimodular nonabelian homogeneous Yang–Baxter deformations of the AdS5×S5 superstring can be realized as sequences of noncommuting TsT transformations. I show that many of them are duals to various noncommutative versions of supersymmetric Yang–Mills theory, structurally determined directly in terms of the associated r matrices, in line with previous expectations in the literature.

Smooth causal patches for AdS black holes

Science.gov (United States)

Raju, Suvrat

2017-06-01

We review the paradox of low energy excitations of a black hole in anti-de Sitter space (AdS). An appropriately chosen unitary operator in the boundary theory can create a locally strong excitation near the black hole horizon, whose global energy is small as a result of the gravitational redshift. The paradox is that this seems to violate a general rule of statistical mechanics, which states that an operator with energy parametrically smaller than k T cannot create a significant excitation in a thermal system. When we carefully examine the position dependence of the boundary unitary operator that produces the excitation and the bulk observable necessary to detect the anomalously large effect, we find that they do not both fit in a single causal patch. This follows from a remarkable property of position-space AdS correlators that we establish explicitly and resolves the paradox in a generic state of the system, since no combination of observers can both create the excitation and observe its effect. As a special case of our analysis, we show how this resolves the "Born rule" paradox of Marolf and Polchinski [J. High Energy Phys. 01 (2016) 008, 10.1007/JHEP01(2016)008] and we verify our solution using an independent calculation. We then consider boundary states that are finely tuned to display a spontaneous excitation outside the causal patch of the infalling observer, and we propose a version of causal patch complementarity in AdS/CFT that resolves the paradox for such states as well.

The CMS HGCAL detector for the HL-LHC upgrade

CERN Document Server

Steen, Arnaud

2017-01-01

The High Luminosity LHC (HL-LHC) will integrate 10 times more luminosity than the LHC, posing significant challenges for radiation tolerance and event pileup on detectors, especially for forward calorimetry, and hallmarks the issue for future colliders. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (ECAL) and hadronic (HCAL) compartments. This will facilitate particle-flow calorimetry, where the fine structure of showers can be measured and used to enhance pileup rejection and particle identification, whilst still achieving good energy resolution. The ECAL and a large fraction of HCAL will be based on hexagonal silicon sensors of 0.5 - 1 cm$^2$ cell size, with the remainder of the HCAL based on highly-segmented scintillators with SiPM readout. The intrinsic high-precision timing capabilities of the silicon sensors wi...

Upgrades of the CMS Outer Tracker for HL-LHC

CERN Document Server

AUTHOR|(CDS)2067159

2016-01-01

The LHC machine is planning an upgrade program which will smoothly bring the luminosity to about 5×1034cm$^{−2}$s$^{−1}$ around 2028, to possibly reach an integrated luminosity of 3000 fb$^{−1}$ in the following decade. This High Luminosity LHC scenario, HL-LHC, will require a preparation program of the LHC detectors known as Phase-2 upgrade. The current CMS Outer Tracker, already running close to its design limits, will not be able to survive HL-LHC radiation conditions and CMS will need a completely new device, in order to fully exploit the highly demanding operating conditions and the delivered luminosity. The new Tracker should have also L1 trigger capabilities. To achieve such goals, R&D; activities are ongoing to explore options and develop solutions that would allow including tracking information at Level-1. The design choices for the CMS Outer Tracker upgrades are discussed along with some highlights of the R&D; activities.

Performances of the HL (Hyperloop) transport system

OpenAIRE

van Goeverden, C.D.; Milakis, D.; Janic, M.; Konings, J.W.; Cools, M.; Limbourg, S.

2017-01-01

This paper deals with an analysis of performances of the HL (Hyperloop) transport system considered as an advanced transport alternative to the existing APT (Air Passenger Transport) and HSR (High Speed Rail) systems. The considered performances are operational, financial, social and environmental. The operational performance include capacity and quality of service provided to the system’s users-passengers with attributes such as door-to-door travel time consisting of the access and egress ti...

Synthesis and the crystal and molecular structures of 4-(piperidyl-1)-2-phenylpyrido[2,3-a]anthraquinone-7,12 Mono- and dibromohydrates (HL)Br . 3H2O and (H2L)Br2 . 3H2O

International Nuclear Information System (INIS)

Kovalchukova, O. V.; Stash, A. I.; Belsky, V. K.; Strashnova, S. B.; Zaitsev, B. E.; Ryabov, M. A.

2009-01-01

4-(Piperidyl-1)-2-phenylpyrido[2,3-a]anthraquinone-7,12 monobromohydrate (HL)Br . 3H 2 O (I) and 4-(piperidyl-1)-2-phenylpyrido[2,3-a]anthraquinone-7,12 dibromohydrate (H 2 L)Br 2 . 3H 2 O (II) are isolated in the crystalline state. The crystal structures of compounds I and II are determined using X-ray diffraction. It is established that the protonation of 4-(piperidyl-1)-2-phenylpyrido[2,3-a]anthraquinone-7,12 proceeds primarily through the pyridine atom at pH 2-3. The attachment of the second proton occurs through the piperidine nitrogen atom at pH ∼ 1.

Heavy-ion operation of HL-LHC

CERN Document Server

Jowett, J M; Versteegen, R

2015-01-01

The heavy-ion physics programme of the LHC will continue during the HL-LHC period with upgraded detectors capable of exploiting several times the design luminosity for nucleus–nucleus (Pb–Pb) collisions. For proton–nucleus (p–Pb) collisions, unforeseen in the original design of the LHC, a comparable increase beyond the 2013 luminosity should be attainable. We present performance projections and describe the operational strategies and relatively modest upgrades to the collider hardware that will be needed to achieve these very significant extensions to the physics potential of the High Luminosity LHC.

Improved viability and activity of neutrophils differentiated from HL-60 cells by co-culture with adipose tissue-derived mesenchymal stem cells

International Nuclear Information System (INIS)

Park, Yoon Shin; Lim, Goh-Woon; Cho, Kyung-Ah; Woo, So-Youn; Shin, Meeyoung; Yoo, Eun-Sun; Chan Ra, Jeong; Ryu, Kyung-Ha

2012-01-01

Highlights: ► Neutropenia is a principal complication of cancer treatment. ► Co-culture of neutrophils with AD-MSC retained cell survival and proliferation and inhibited neutrophil apoptosis under serum starved conditions. ► AD-MSC increased functions of neutrophil. ► AD-MSC promoted the viability of neutrophils by enhancing respiratory burst through the expression of IFN-α, G-CSF, and TGF-β. ► AD-MSC can be used to improve immunity for neutropenia treatment. -- Abstract: Neutropenia is a principal complication of cancer treatment. We investigated the supportive effect of adipose tissue-derived mesenchymal stem cells (AD-MSCs) on the viability and function of neutrophils. Neutrophils were derived from HL-60 cells by dimethylformamide stimulation and cultured with or without AD-MSCs under serum-starved conditions to evaluate neutrophil survival, proliferation, and function. Serum starvation resulted in the apoptosis of neutrophils and decreased cell survival. The co-culture of neutrophils and AD-MSCs resulted in cell survival and inhibited neutrophil apoptosis under serum-starved conditions. The survival rate of neutrophils was prolonged up to 72 h, and the expression levels of interferon (IFN)-α, granulocyte colony-stimulating factor (G-CSF), granulocyte–macrophage colony-stimulating factor, and transforming growth factor (TGF)-β in AD-MSCs were increased after co-culture with neutrophils. AD-MSCs promoted the viability of neutrophils by inhibiting apoptosis as well as enhancing respiratory burst, which could potentially be mediated by the increased expression of IFN-α, G-CSF, and TGF-β. Thus, we conclude that the use of AD-MSCs may be a promising cell-based therapy for increasing immunity by accelerating neutrophil function.

Synthesis IR spectra and crystal structure of N-(4-bromophenyl)-1,1,1-trifluoroacetyl-acetonimine HN(C6H4Br)xC(Me)xCHxC(CF3)xO(HL) and its molecular complex with tungstene(4) oxotetrachloride WOCl4xHL

International Nuclear Information System (INIS)

Sergienko, V.S.; Ilyukhin, A.B.; Abramenko, V.L.

1997-01-01

Synthesis, IR spectroscopic and X-ray diffraction studies of compound HN(C 6 H 4 Br)xC(Me)xCHxC(CF 3 )xO(HL) (1) and of molecular complex WOCl 4 xHL(2) have been conducted. In 1 and 2 HL molecule exists in ketoamine tautomeric form (acid proton is localized at nitrogen atom). The results of 1 and 2 study are compared with literature data on structures of HL type molecules and Mo(6) molecular complexes with β-enaminevinylketone, as well as with the structure of chelate compound WOCl 3 L 1 , where L 1 - anion of N-phenylacetylacetonimine

Twistor description of spinning particles in AdS

Science.gov (United States)

Arvanitakis, Alex S.; Barns-Graham, Alec E.; Townsend, Paul K.

2018-01-01

The two-twistor formulation of particle mechanics in D-dimensional anti-de Sitter space for D = 4 , 5 , 7, which linearises invariance under the AdS isometry group Sp(4; K ) for K=R,C,H, is generalized to the massless N -extended "spinning particle". The twistor variables are gauge invariant with respect to the initial N local worldline supersymmetries; this simplifies aspects of the quantum theory such as implications of global gauge anomalies. We also give details of the two-supertwistor form of the superparticle, in particular the massive superparticle on AdS5.

The effect of types of banner ad, Web localization, and customer involvement on Internet users' attitudes.

Science.gov (United States)

Chen, Jengchung Victor; Ross, William H; Yen, David C; Akhapon, Lerdsuwankij

2009-02-01

In this study, three characteristics of Web sites were varied: types of banner ad, Web localization, and involvement in purchasing a product. The dependent variable was attitude toward the site. In laboratory experiments conducted in Thailand and Taiwan, participants browsed versions of a Web site containing different types of banner ads and products. As a within-participants factor, each participant browsed both a standardized English-language Web site and a localized Web site. Results showed that animated (rather than static) banner ads, localized versions (rather than a standardized version) of Web sites, and high (rather than low) product involvement led to favorable attitudes toward the site.

Quantum spectral curve for the η-deformed AdS5 × S5 superstring

Science.gov (United States)

Klabbers, Rob; van Tongeren, Stijn J.

2017-12-01

The spectral problem for the AdS5 ×S5 superstring and its dual planar maximally supersymmetric Yang-Mills theory can be efficiently solved through a set of functional equations known as the quantum spectral curve. We discuss how the same concepts apply to the η-deformed AdS5 ×S5 superstring, an integrable deformation of the AdS5 ×S5 superstring with quantum group symmetry. This model can be viewed as a trigonometric version of the AdS5 ×S5 superstring, like the relation between the XXZ and XXX spin chains, or the sausage and the S2 sigma models for instance. We derive the quantum spectral curve for the η-deformed string by reformulating the corresponding ground-state thermodynamic Bethe ansatz equations as an analytic Y system, and map this to an analytic T system which upon suitable gauge fixing leads to a Pμ system - the quantum spectral curve. We then discuss constraints on the asymptotics of this system to single out particular excited states. At the spectral level the η-deformed string and its quantum spectral curve interpolate between the AdS5 ×S5 superstring and a superstring on "mirror" AdS5 ×S5, reflecting a more general relationship between the spectral and thermodynamic data of the η-deformed string. In particular, the spectral problem of the mirror AdS5 ×S5 string, and the thermodynamics of the undeformed AdS5 ×S5 string, are described by a second rational limit of our trigonometric quantum spectral curve, distinct from the regular undeformed limit.

Beam Cleaning in Experimental IRs in HL-LHC for the Incoming Beam

CERN Document Server

Garcia-Morales, H; Bruce, Roderik; Redaelli, Stefano

2015-01-01

The HL-LHC will store 675 MJ of energy per beam, about 300 MJ more than the nominal LHC. Due to the increase in stored energy and a different interaction region (IR) optics layout, the collimation system for the incoming beam must be revisited in order to avoid dangerous losses that could cause quenches or machine damage. This paper studies the effectiveness of the current LHC collimation system in intercepting cleaning losses close to the experiments in the HL-LHC. The study reveals that additional tertiary collimators would be beneficial in order to protect not only the final focusing triplets but also the two quadrupoles further upstream.

Beam cleaning of the incoming beam in experimental IRs in HL-LHC

CERN Document Server

Garcia Morales, Hector; Redaelli, Stefano; De Maria, Riccardo; CERN. Geneva. ATS Department

2017-01-01

The HL-LHC will store 675 MJ of energy per beam, about 300 MJ more than the nominal LHC. Due to the increase in stored energy and a different interaction region (IR) layout and optics design, the collimation system for the incoming beam must be revisited in order to avoid dangerous losses that could cause quenches and machine damage. This paper studies the effectiveness of the current LHC collimation system in intercepting cleaning losses close to the experiments in the HL-LHC. The study reveals that in addition to the triplet also the Q4 needs local protection, which could be provided by an additional pair of TCTs.

A Study on New Pochonka Published in A.D. 1792

Science.gov (United States)

Ahn, Sang-Hyeon

2009-12-01

New Pochonka published in the eighteenth century of the Choson dynasty was composed of star-charts based on the new observations made by Jesuits in China and songs corrected a little bit from previous version of Pochonka. The asterisms in the previous Pochonka are listed in the same order to that in the Song dynasty's literature; while the asterisms in the new Pochonka are listed in accordance with Pu-tien-ko published in China after the Ming dynasty. The Chinese-style twelve-equatorial-section system is adopted in the new Pochonka, while in its song is adopted the zodiac system, which can be seen in the star-charts of previous version of Pochonka. The asterisms belonging to three or four neighboring lunar-mansions are drawn in one chart. Each chart covers asterisms not belonging to a certain range of right ascension, but to a certain lunar mansion. We estimate the forming era of the new Pochonka from the following facts; that the Ling-Tai-I-Hsiang-Chih was used to make charts and footnotes whose archetype can be found in the Chinese literature around A.D. 1700, that these Chinese books were imported into Choson in A.D. 1709, that the naming taboo to the emperor Khang-Hsi was used, that the order of Shen-Hsiu (參宿) was transposed with Tshui-Hsiu (자宿), and that the new Pochonka was substituted for the old version when the rules of Royal Astronomical Bureau was reformed in A.D. 1791. In conclusion, the parent sources of the charts and footnotes of the new Pochonka might be imported from the Ching dynasty around 1709 A.D. to form the new Pochonka between A.D. 1709 and A.D. 1791, and finally to be published in A.D. 1792. We discuss the possible future works to make a firm conclusion.

Experiment of laser thomson scattering at HL-1 tokamak device

International Nuclear Information System (INIS)

Zuo Henian; Chen Jiafu; Yan Derong; Liu Aiping; Shi Peilan; Wang Wei; Liu Xiaomei

1989-05-01

The structure and performance of the Ruby Laser Thomson Scattering apparatus for HL-1 tokamak device is described. The method of acquisition and calibration of multichannel scattered signals are presented. Examples of measured electron temperature T. with experimental error are given

Analysis of the plasma magnetohydrodynamic equilibrium in iron core transformer Tokamak HL-1M

International Nuclear Information System (INIS)

Chen Xiaoguang; Yuan Baoshan

1992-01-01

The physical and mathematical model are presented on the problem of MHD equilibrium with the self consistent in iron core transformer HL-1M. Calculation and analysis for the plasma equilibrium of the stable boundary and free boundary are shown respectively, in an axisymmetric equilibrium model of two dimensions. First, a variation formulation of the problem is written and the equations of the poloided flux ψ are solved by a finite element method; the Picard and Newton algorithms are tested for the non-linearities. The plasma boundary and the magnetic surfaces are being simulated, with the currents in the coils, the total plasma current, its current density function and the magnetic permeability of the iron being the data for the problem; a certain number of the characteristic parameter of the equilibrium configuration is calculated. Secondly, a simple method of calculation is adopted in the determination of equilibrium fields and currents in iron core HL-1M tokamak device. In the plasma equilibrium, the magnetic effect of the air gaps in the iron core and the iron magnetic shielded plate are considered in HL-1M device. Reliable data are provided for designing and constructing the poloidal field system of HL-1M device. A good computer code is constructed, which may be useful in operating on analysis for the future device

The clinical value of 99Tcm-HL91 hypoxia imaging combined with the detection of serum NSE, CEA and CYFRA21-1 in the diagnosis of lung cancer

International Nuclear Information System (INIS)

Li Xiaohong; Wang Yingqiu; Sun Gaofeng; Zhang Anyu; Zuo Changjing

2012-01-01

Objective: To investigate the value of 99 Tc m -HL91 hypoxia imaging combined the detection of serum neuron-specific enolase (NSE), carcinoembryonic antigen(CEA) and cytokeratin 19 fragment (CYFRA21-1) in the diagnosis of lung cancer. Methods: 63 patients with lung neoplasm were carried out 99 Tc m -Hail hypoxia imaging, and the serum tumor markers levels of Nose, Cea and CYFRA21-1 were detected. The sensitivity, specificity and accuracy of each and combined method were calculated respectively and compared with each other. Results: The sensitivity,specificity and accuracy in diagnosis of lung cancer with 99 Tc m -HL91 hypoxia imaging were 85.4%, 100% and 88.9% respectively; and with serum tumor markers NSE, CEA and CYFRA21-1 detection were 72.9%, 86.7% and 76.1% respectively. Compared with the detection of serum tumor marker levels of NSE, CEA and CYFRA21-1, 99 Tc m -HL91 hypoxia imaging had the higher sensitivity and specificity,and similar accuracy. The sensitivity, specificity and accuracy of combined two methods in diagnosis of lung cancer were 95.8%, 86.7% and 93.6% respectively. The sensitivity and accuracy of the combined method were significantly increased than single method (P 0.05). Conclusion: 99 Tc m -HL91 hypoxia imaging and the detection of serum level of NSE, CEA and CYFRA21-1 have an important diagnostic value, and their combination could improve the sensitivity and accuracy in the diagnosis of lung cancer. (authors)

Potentially inappropriate medicines in elderly hospitalised patients according to the EU(7)-PIM list, STOPP version 2 criteria and comprehensive protocol.

Science.gov (United States)

Mucalo, Iva; Hadžiabdić, Maja Ortner; Brajković, Andrea; Lukić, Sonja; Marić, Patricia; Marinović, Ivana; Bačić-Vrca, Vesna

2017-08-01

The aim of this study was to measure the prevalence of potentially inappropriate medications (PIMs) by using the EU(7)-PIM list, STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions) version 2 criteria and the new comprehensive protocol. This prospective study involved a sample of 276 consecutive elderly patients discharged from the university teaching hospital. Age, gender, diagnoses, medication history and medicines at discharge were recorded. The main outcome measure was the prevalence of PIMs according to each set of criteria: EU(7)-PIM list, STOPP version 2 criteria and comprehensive protocol. The median patient age (range) was 74 (65-92) years. The median number of prescribed medications was 7 (1-17). STOPP identified 393 PIMs affecting 190 patients (69%), EU(7)-PIM list identified 330 PIMs in 184 patients (66.7%) whilst the comprehensive protocol identified 134 PIMs in 102 patients (37%). STOPP version 2 criteria identified significantly more PIMs per patient than the other two protocols (p comprehensive protocol and was found as a more sensitive tool for PIM detection.

Prevalence, birth incidence, and penetrance of von Hippel-Lindau disease (vHL) in Denmark

DEFF Research Database (Denmark)

Binderup, Marie Louise Mølgaard; Galanakis, Michael Carter Bisgaard; Budtz-Jørgensen, Esben

2017-01-01

the international diagnostic criteria. We found an overall penetrance of 87% at age 60 years. When considering only vHL patients who have not attended surveillance, 20% will still be asymptomatic at age 60 years. This should be considered in the context of genetic counselling, especially when assessing the risk...... of vHL in asymptomatic adult first-degree relatives who are often not genetically tested.European Journal of Human Genetics advance online publication, 14 December 2016; doi:10.1038/ejhg.2016.173....

Characterization of the binding of [3H]-(+/-)-L-364,718: a new potent, nonpeptide cholecystokinin antagonist radioligand selective for peripheral receptors

International Nuclear Information System (INIS)

Chang, R.S.; Lotti, V.J.; Chen, T.B.; Kunkel, K.A.

1986-01-01

[3H]-(+/-)-L-364,718 a new, potent and selective nonpeptide peripheral cholecystokinin (CCK) antagonist bound saturably and reversibly to rat pancreatic membranes. The radioligand recognized a single class of binding sites with a high affinity (Kd = 0.23 nM). The binding of [ 3 H]-(+/-)-L-364,718 was stereospecific in that the more biologically active (-)-enantiomer demonstrated greater potency than the (+)-enantiomer. The rank order of potency of various CCK agonists and antagonists in displacing [ 3 H]-(+/-)-L-364,718 correlated with their ability to displace [ 125 I]CCK-8 and their known pharmacological activities in peripheral tissues. However, the absolute potencies of agonists were greater in displacing [ 125 I]CCK-8 than [ 3 H]-(+/-)-L-364,718. As described for other physiologically relevant receptor systems, the potency for displacement of [ 3 H]-(+/-)-L-364,718 binding by CCK agonists, but not antagonists, was reduced by guanosine 5'-(beta, gamma-imido)triphosphate and NaCl and enhanced by MgCl 2 . [ 3 H]-(+/-)-L-364,718 also demonstrated specific binding to bovine gall bladder tissue but not guinea pig brain or gastric glands, consistent with its selectivity as a peripheral CCK antagonist. [ 3 H]-(+/-)-L-364,718 binding to pancreatic membranes was not affected by various pharmacological agents known to interact with other common peptide and nonpeptide receptor systems. These data indicate that [ 3 H]-(+/-)-L-364,718 represents a new potent nonpeptide antagonist radioligand for the study of peripheral CCK receptors which may allow differentiation of agonist and antagonist interactions

Mission Data System Java Edition Version 7

Science.gov (United States)

Reinholtz, William K.; Wagner, David A.

2013-01-01

The Mission Data System framework defines closed-loop control system abstractions from State Analysis including interfaces for state variables, goals, estimators, and controllers that can be adapted to implement a goal-oriented control system. The framework further provides an execution environment that includes a goal scheduler, execution engine, and fault monitor that support the expression of goal network activity plans. Using these frameworks, adapters can build a goal-oriented control system where activity coordination is verified before execution begins (plan time), and continually during execution. Plan failures including violations of safety constraints expressed in the plan can be handled through automatic re-planning. This version optimizes a number of key interfaces and features to minimize dependencies, performance overhead, and improve reliability. Fault diagnosis and real-time projection capabilities are incorporated. This version enhances earlier versions primarily through optimizations and quality improvements that raise the technology readiness level. Goals explicitly constrain system states over explicit time intervals to eliminate ambiguity about intent, as compared to command-oriented control that only implies persistent intent until another command is sent. A goal network scheduling and verification process ensures that all goals in the plan are achievable before starting execution. Goal failures at runtime can be detected (including predicted failures) and handled by adapted response logic. Responses can include plan repairs (try an alternate tactic to achieve the same goal), goal shedding, ignoring the fault, cancelling the plan, or safing the system.

Decadal-Scale Responses in Middle and Upper Stratospheric Ozone From SAGE II Version 7 Data

Science.gov (United States)

Remsberg, E. E.

2014-01-01

Stratospheric Aerosol and Gas Experiment (SAGE II) version 7 (v7) ozone profiles are analyzed for their decadal-scale responses in the middle and upper stratosphere for 1991 and 1992-2005 and compared with those from its previous version 6.2 (v6.2). Multiple linear regression (MLR) analysis is applied to time series of its ozone number density vs. altitude data for a range of latitudes and altitudes. The MLR models that are fit to the time series data include a periodic 11 yr term, and it is in-phase with that of the 11 yr, solar UV (Ultraviolet)-flux throughout most of the latitude/ altitude domain of the middle and upper stratosphere. Several regions that have a response that is not quite in-phase are interpreted as being affected by decadal-scale, dynamical forcings. The maximum minus minimum, solar cycle (SClike) responses for the ozone at the low latitudes are similar from the two SAGE II data versions and vary from about 5 to 2.5% from 35 to 50 km, although they are resolved better with v7. SAGE II v7 ozone is also analyzed for 1984-1998, in order to mitigate effects of end-point anomalies that bias its ozone in 1991 and the analyzed results for 1991-2005 or following the Pinatubo eruption. Its SC-like ozone response in the upper stratosphere is of the order of 4%for 1984-1998 vs. 2.5 to 3%for 1991-2005. The SAGE II v7 results are also recompared with the responses in ozone from the Halogen Occultation Experiment (HALOE) that are in terms of mixing ratio vs. pressure for 1991-2005 and then for late 1992- 2005 to avoid any effects following Pinatubo. Shapes of their respective response profiles agree very well for 1992-2005. The associated linear trends of the ozone are not as negative in 1992-2005 as in 1984-1998, in accord with a leveling off of the effects of reactive chlorine on ozone. It is concluded that the SAGE II v7 ozone yields SC-like ozone responses and trends that are of better quality than those from v6.2.

B-physics studies for HL-LHC ATLAS upgrade

CERN Document Server

Jakoubek, Tomas; The ATLAS collaboration

2017-01-01

Simulation studies were made to estimate ATLAS HL-LHC upgrade performance for B-physics. In particular, the decay of $B_s^0 \\to J/\\psi\\phi$ is studied in order to measures the $CP$ violating mixing phase and the width difference between the $B_s^0$ eigenstates. The increased sensitivity is related mainly to the improved decay time resolution obtained with the upgraded ITk inner tracking detector.

Simulation of the MHD stabilities of the experiment on HL-2A tokamak by GATO code

International Nuclear Information System (INIS)

Pan Wei; Chen Liaoyuan; Dong Jiaqi; Shen Yong; Zhang Jinhua

2009-01-01

The ideal two-dimensional MHD stabilities code, GATO, has been successfully immigrated to the high-performance computing system of HL-2A and used to the simulation study of the ideal MHD stabilities of the plasmas produced by one of the pellets injection experiments on HL-2A tokamak. The EFIT code was used to reconstruct the equilibrium configures firstly and the GATO was used to compute their MHD stabilities secondly whose source data were obtained by the NO.4050 discharge of the experiments on HL-2A, and finally by analyzing these results the preliminary conclusion was devised that the confinement performance of the plasma was improved because of the stabilization effect of the anti-sheared configures created by the pellets injection. (authors)

Inward rectifier potassium channels in the HL-1 cardiomyocyte-derived cell line.

Science.gov (United States)

Goldoni, Dana; Zhao, YouYou; Green, Brian D; McDermott, Barbara J; Collins, Anthony

2010-11-01

HL-1 is a line of immortalized cells of cardiomyocyte origin that are a useful complement to native cardiomyocytes in studies of cardiac gene regulation. Several types of ion channel have been identified in these cells, but not the physiologically important inward rectifier K(+) channels. Our aim was to identify and characterize inward rectifier K(+) channels in HL-1 cells. External Ba(2+) (100 µM) inhibited 44 ± 0.05% (mean ± s.e.m., n = 11) of inward current in whole-cell patch-clamp recordings. The reversal potential of the Ba(2+)-sensitive current shifted with external [K(+)] as expected for K(+)-selective channels. The slope conductance of the inward Ba(2+)-sensitive current increased with external [K(+)]. The apparent Kd for Ba(2+) was voltage dependent, ranging from 15 µM at -150  mV to 148 µM at -75  mV in 120  mM external K(+). This current was insensitive to 10 µM glybenclamide. A component of whole-cell current was sensitive to 150 µM 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), although it did not correspond to the Ba(2+)-sensitive component. The effect of external 1 mM Cs(+) was similar to that of Ba(2+). Polymerase chain reaction using HL-1 cDNA as template and primers specific for the cardiac inward rectifier K(ir)2.1 produced a fragment of the expected size that was confirmed to be K(ir)2.1 by DNA sequencing. In conclusion, HL-1 cells express a current that is characteristic of cardiac inward rectifier K(+) channels, and express K(ir)2.1 mRNA. This cell line may have use as a system for studying inward rectifier gene regulation in a cardiomyocyte phenotype. © 2010 Wiley-Liss, Inc.

Content-Aware Adaptive Compression of Satellite Imagery Using Artificial Vision

Science.gov (United States)

2013-09-01

pixel samples. The S vector, once calculated, will be passed onto the SVM. Note: The LL sub-band is not part of the S vector. aVn =< LH1,LH2...LHm >,aHn...HL1,HL2...HLm >,aDn =< HH1,HH2...HHm > (3.7) S =< aV0,aH0,aD0,aV1,aH1,aD1... aVn ,aHn,aDn > (3.8) 3.3.2 Training OASIC uses a single 512× 512 pixel

In memoriam Dieter Möhl his life as a scientist, mentor and friend

CERN Document Server

Caspers, Fritz

2013-01-01

The scientific life of Dieter Möhl can be split up into four major categories; namely accelerators where he made major contributions, theory and teaching, advice to the management and human relations including human rights. Regarding the first point it should be recalled that Dieter is one of the founding fathers of LEAR and in parallel worked a lot on ICE, the PS as well as the AAC until it became the AD. The list of other machines (not always built) which have profited from his contributions is very long and include the RCS, SuperLEAR, Tau-charm and neutrino factories and also various rings of FAIR. Dieter was one of leading theorists in accelerator physics making fundamental contributions to stochastic cooling, ordered beam issues, electron cooling, polarized beams and beam stability problems. He was very often called in for advice by the management, not only at CERN but in numerous advisory committees. His excellent human qualities are known worldwide and they are held in the highest esteem in particular...

Nuclear waste glass product consistency test (PCT): Version 7.0. Revision 3

International Nuclear Information System (INIS)

Jantzen, C.M.; Bibler, N.E.; Beam, D.C.; Ramsey, W.G.

1994-06-01

Liquid high-level nuclear waste will be immobilized at the Savannah River Site (SRS) by vitrification in borosilicate glass. The glass will be produced in the Defense Waste Processing Facility (DWPF), poured into stainless steel canisters, and eventually disposed of in a geologic repository. In order to comply with the Waste Acceptance Product Specifications (WAPS), the durability of the glass needs to be measured during production to assure its long term stability and radionuclide release properties. A durability test, designated the Product Consistency Test (PCT), was developed for DWPF glass in order to meet the WAPS requirements. The response of the PCT procedure was based on extensive testing with glasses of widely different compositions. The PCT was determined to be very reproducible, to yield reliable results rapidly, and to be easily performed in shielded cell facilities with radioactive samples. Version 7.0 of the PCT procedure is attached. This draft version has been submitted to ASTM for full committee (C26, Nuclear Fuel Cycle) ballot after being balloted successfully through subcommittee C26.13 on Repository Waste Package Materials Testing

Optical data transmission ASICs for the high-luminosity LHC (HL-LHC) experiments

International Nuclear Information System (INIS)

Li, X; Huang, G; Sun, X; Liu, G; Deng, B; Gong, D; Guo, D; Liu, C; Liu, T; Xiang, A C; Ye, J; Zhao, X; Chen, J; You, Y; He, M; Hou, S; Teng, P-K; Jin, G; Liang, H; Liang, F

2014-01-01

We present the design and test results of two optical data transmission ASICs for the High-Luminosity LHC (HL-LHC) experiments. These ASICs include a two-channel serializer (LOCs2) and a single-channel Vertical Cavity Surface Emitting Laser (VCSEL) driver (LOCld1V2). Both ASICs are fabricated in a commercial 0.25-μm Silicon-on-Sapphire (SoS) CMOS technology and operate at a data rate up to 8 Gbps per channel. The power consumption of LOCs2 and LOCld1V2 are 1.25 W and 0.27 W at 8-Gbps data rate, respectively. LOCld1V2 has been verified meeting the radiation-tolerance requirements for HL-LHC experiments

Improved viability and activity of neutrophils differentiated from HL-60 cells by co-culture with adipose tissue-derived mesenchymal stem cells

Energy Technology Data Exchange (ETDEWEB)

Park, Yoon Shin; Lim, Goh-Woon [Department of Pediatrics, Ewha Womans University, School of Medicine, Ewha Medical Research Center, Seoul (Korea, Republic of); Cho, Kyung-Ah; Woo, So-Youn; Shin, Meeyoung [Department of Microbiology, Ewha Womans University, School of Medicine, Ewha Medical Research Center, Seoul (Korea, Republic of); Yoo, Eun-Sun [Department of Pediatrics, Ewha Womans University, School of Medicine, Ewha Medical Research Center, Seoul (Korea, Republic of); Chan Ra, Jeong [Stem Cell Research Center, RNL BIO, Seoul 153-768 (Korea, Republic of); Ryu, Kyung-Ha, E-mail: ykh@ewha.ac.kr [Department of Pediatrics, Ewha Womans University, School of Medicine, Ewha Medical Research Center, Seoul (Korea, Republic of)

2012-06-22

Highlights: Black-Right-Pointing-Pointer Neutropenia is a principal complication of cancer treatment. Black-Right-Pointing-Pointer Co-culture of neutrophils with AD-MSC retained cell survival and proliferation and inhibited neutrophil apoptosis under serum starved conditions. Black-Right-Pointing-Pointer AD-MSC increased functions of neutrophil. Black-Right-Pointing-Pointer AD-MSC promoted the viability of neutrophils by enhancing respiratory burst through the expression of IFN-{alpha}, G-CSF, and TGF-{beta}. Black-Right-Pointing-Pointer AD-MSC can be used to improve immunity for neutropenia treatment. -- Abstract: Neutropenia is a principal complication of cancer treatment. We investigated the supportive effect of adipose tissue-derived mesenchymal stem cells (AD-MSCs) on the viability and function of neutrophils. Neutrophils were derived from HL-60 cells by dimethylformamide stimulation and cultured with or without AD-MSCs under serum-starved conditions to evaluate neutrophil survival, proliferation, and function. Serum starvation resulted in the apoptosis of neutrophils and decreased cell survival. The co-culture of neutrophils and AD-MSCs resulted in cell survival and inhibited neutrophil apoptosis under serum-starved conditions. The survival rate of neutrophils was prolonged up to 72 h, and the expression levels of interferon (IFN)-{alpha}, granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor, and transforming growth factor (TGF)-{beta} in AD-MSCs were increased after co-culture with neutrophils. AD-MSCs promoted the viability of neutrophils by inhibiting apoptosis as well as enhancing respiratory burst, which could potentially be mediated by the increased expression of IFN-{alpha}, G-CSF, and TGF-{beta}. Thus, we conclude that the use of AD-MSCs may be a promising cell-based therapy for increasing immunity by accelerating neutrophil function.

Nenápadné významy Hlávkova mostu

Czech Academy of Sciences Publication Activity Database

Hnídková, Vendula

2015-01-01

Roč. 94, č. 12 (2015), s. 722-724 ISSN 0042-4544 Institutional support: RVO:68378033 Keywords : Czech modern architecture * Pavel Janák * Hlávka bridge Subject RIV: AL - Art, Architecture , Cultural Heritage

Towards Optimum Material Choices for HL-LHC Collimator Upgrade

CERN Document Server

Quaranta, E.; Biancacci, N.; Bruce, R.; Carra, F.; Métral, E.; Redaelli, S.; Rossi, A.; Salvant, B.

2016-01-01

properties that address different limitations of the present collimation system, solutions have been found to fulfil various upgrade challenges. This paper describes the proposed staged approach to deploy new materials in the upgraded HL-LHC collimation system. Beam tests at the CERN HiRadMat facility were also performed to benchmark simulation methods and constitutive material models.

Plasma electron density measurement with multichannel microwave interferometer on the HL-1 tokamak device

International Nuclear Information System (INIS)

Xu Deming; Zhang Hongyin; Liu Zetian; Ding Xuantong; Li Qirui; Wen Yangxi

1989-11-01

A multichannel microwave interferometer which is composed of different microwave interferometers (one 2 mm band, one 4 mm band and two 8 mm band) has been used to measure the plasma electron density on HL-1 tokamak device. The electron density approaching to 5 x 10 13 cm -3 is measured by a 2 mm band microwave interferometer. In the determinable range, the electron density profile in the cross-section on HL-1 device has been measured by this interferometer. A microcomputer data processing system is also developed

Bounding the HL-index of a graph: a majorization approach.

Science.gov (United States)

Clemente, Gian Paolo; Cornaro, Alessandra

2016-01-01

In mathematical chemistry, the median eigenvalues of the adjacency matrix of a molecular graph are strictly related to orbital energies and molecular orbitals. In this regard, the difference between the occupied orbital of highest energy (HOMO) and the unoccupied orbital of lowest energy (LUMO) has been investigated (see Fowler and Pisansky in Acta Chim. Slov. 57:513-517, 2010). Motivated by the HOMO-LUMO separation problem, Jaklič et al. in (Ars Math. Contemp. 5:99-115, 2012) proposed the notion of HL -index that measures how large in absolute value are the median eigenvalues of the adjacency matrix. Several bounds for this index have been provided in the literature. The aim of the paper is to derive alternative inequalities to bound the HL -index. By applying majorization techniques and making use of some known relations, we derive new and sharper upper bounds for this index. Analytical and numerical results show the performance of these bounds on different classes of graphs.

The CMS Tracker Upgrade for HL-LHC\\\\ Sensor R$\\&$D

CERN Document Server

Naseri, Mohsen

2014-01-01

At an instantaneous luminosity of 5~$\\times10^{34}~cm^{-2}~s^{-1}$, the high-luminosity phase of the Large Hadron Collider (HL-LHC) is expected to deliver a total of 3000~fb$^{-1}$ of collisions, hereby increasing the discovery potential of the LHC experiments significantly. However, the radiation environment of the tracking system will be severe, requiring new radiation hard sensors for the CMS tracker. Focusing on the upgrade of the outer tracker region, the CMS tracker collaboration has almost completed a large material investigation and irradiation campaign to identify the silicon material and design that fulfils all requirements of a new tracking detector at HL-LHC. Focusing on the upgrade of the outer tracker region, pad diodes as well as fully functional strip sensors have been implemented on silicon wafers with different material properties and thicknesses. The samples were irradiated with a mixture of neutrons and protons corresponding to fluences as expected for various positions in the future track...

Magnetic Frequency Response of HL-LHC Beam Screens

Energy Technology Data Exchange (ETDEWEB)

Morrone, M. [CERN; Martino, M. [CERN; De Maria, R. [CERN; Fitterer, M. [Fermilab; Garion, C. [CERN

2017-10-12

Magnetic fields used to control particle beams in accelerators are usually controlled by regulating the electrical current of the power converters. In order to minimize lifetime degradation and ultimately luminosity loss in circular colliders, current-noise is a highly critical figure of merit of power converters, in particular for magnets located in areas with high beta-function, like the High Luminosity Large Hadron Collider (HL-LHC) insertions. However, what is directly acting upon the beam is the magnetic field and not the current of the power converter, which undergoes several frequency-dependent transformations until the desired magnetic field, seen by the beam, is obtained. Beam screens are very rarely considered when assessing or specifying the noise figure of merit, but their magnetic frequency response is such that they realize relatively effective low pass filtering of the magnetic field produced by the system magnet-power converter. This work aims at filling this gap by quantifying the expected impact of different beam screen layouts for the most relevant HL-LHC insertion magnets. A welldefined post-processing technique is used to derive the frequency response of the different multipoles from multi-physics Finite Element Method (FEM) simulation results. In addition, a well approximated analytical formula for the low-frequency range of multi-layered beam screens is presented.

Performances and ageing study of resistive-anodes Micromegas detectors for HL-LHC environment

CERN Document Server

Jeanneau, F; Attié, D; Boyer, M; Derré, J; Fanourakis, G; Ferrer-Ribas, E; Galán, J; Gazis, E; Geralis, T; Giganon, A; Giomataris, I; Herlant, S; Manjarrés, J; Ntomari, E; Schune, Ph; Titov, M; Tsipolitis, G

2012-01-01

With the tenfold luminosity increase envisaged at the HL-LHC, the background (photons, neutrons, ...) and the event pile-up probability are expected to increase in proportion in the different experiments, especially in the forward regions like, for instance, the muons chambers of the ATLAS detector. Detectors based on the Micromegas principle should be good alternatives for the detector upgrade in the HL-LHC framework because of a good spatial ( 98%) can be achieved with resistive-anode micromegas detector. An X-rays irradiation has been also performed, showing no ageing effect after more than 21 days exposure and an integrated charge of almost 1C.

Involvement of the histamine H4 receptor in clozapine-induced hematopoietic toxicity: Vulnerability under granulocytic differentiation of HL-60 cells

International Nuclear Information System (INIS)

Goto, Aya; Mouri, Akihiro; Nagai, Tomoko; Yoshimi, Akira; Ukigai, Mako; Tsubai, Tomomi; Hida, Hirotake; Ozaki, Norio; Noda, Yukihiro

2016-01-01

Clozapine is an effective antipsychotic for treatment-resistant schizophrenia, but can cause fatal hematopoietic toxicity as agranulocytosis. To elucidate the mechanism of hematopoietic toxicity induced by clozapine, we developed an in vitro assay system using HL-60 cells, and investigated the effect on hematopoiesis. HL-60 cells were differentiated by all-trans retinoic acid (ATRA) into three states according to the following hematopoietic process: undifferentiated HL-60 cells, those undergoing granulocytic ATRA-differentiation, and ATRA-differentiated granulocytic cells. Hematopoietic toxicity was evaluated by analyzing cell survival, cell proliferation, granulocytic differentiation, apoptosis, and necrosis. In undifferentiated HL-60 cells and ATRA-differentiated granulocytic cells, both clozapine (50 and 100 μM) and doxorubicin (0.2 µM) decreased the cell survival rate, but olanzapine (1–100 µM) did not. Under granulocytic differentiation for 5 days, clozapine, even at a concentration of 25 μM, decreased survival without affecting granulocytic differentiation, increased caspase activity, and caused apoptosis rather than necrosis. Histamine H 4 receptor mRNA was expressed in HL-60 cells, whereas the expression decreased under granulocytic ATRA-differentiation little by little. Both thioperamide, a histamine H 4 receptor antagonist, and DEVD-FMK, a caspase-3 inhibitor, exerted protection against clozapine-induced survival rate reduction, but not of live cell counts. 4-Methylhistamine, a histamine H 4 receptor agonist, decreased the survival rate and live cell counts, as did clozapine. HL-60 cells under granulocytic differentiation are vulnerable under in vitro assay conditions to hematopoietic toxicity induced by clozapine. Histamine H 4 receptor is involved in the development of clozapine-induced hematopoietic toxicity through apoptosis, and may be a potential target for preventing its occurrence through granulocytic differentiation. - Highlights: • HL-60

Differentiation-inducing effects of small fruit juices on HL-60 leukemic cells.

Science.gov (United States)

Yoshizawa, Y; Kawaii, S; Urashima, M; Fukase, T; Sato, T; Murofushi, N; Nishimura, H

2000-08-01

Epidemiological studies indicate that high intakes of fruits and vegetables are associated with a reduced risk of cancer, and several plant-derived drugs have been developed in medical oncology. Since only a small part of the flora has been tested for any kind of bioactivity, we chose small fruits as sources of differentiation-inducing activity against HL-60 leukemic cells. We have prepared juices from various small fruits that grow mainly in the northern part of Japan. Screening of 43 samples indicated that juices of Actinidia polygama Maxim., Rosa rugosa Thunb., Vaccinium smallii A. Gray, and Sorbus sambucifolia Roem. strongly induced differentiation of HL-60 cells to monocyte/macrophage characteristics in a concentration-dependent manner as indicated by histochemical and biochemical examinations.

Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells.

Science.gov (United States)

Mata-Greenwood, E; Ito, A; Westenburg, H; Cui, B; Mehta, R G; Kinghorn, A D; Pezzuto, J M

2001-01-01

Non-physiological inducers of terminal differentiation have been used as novel therapies for the prevention and therapy of cancer. We have used cultured HL-60 promyelocytic cells to monitor differentiation, proliferation and cell death events as induced by a large set of extracts derived from plants. Screening of more than 1400 extracts led to the discovery of 34 with potent activity (ED50 Petiveria alliacea, and desmethylrocaglamide from Aglaia ponapensis. Zapotin demonstrated the most favorable biological profile in that induction of differentiation correlated with proliferation arrest, and a lack of cytotoxicity. We conclude that the HL-60 cell model is a useful system for the discovery of novel pharmacophores with potential to suppress the process of carcinogenesis, and that flavonoids may be especially useful in this capacity.

Preliminary design of HL-2A discharge control system

International Nuclear Information System (INIS)

Jiang Chao; Song Xianming; Li Qiang

2001-01-01

HL-2A Discharge Control System consists of one or more VXI work stations so as to compose an all digital control system. The DCS are used to measure and control the poloidal coils, the main tasks of the poloidal coils are exploding, keeping and controlling the current of plasma. These coils explode plasma and keep it in the determined position

High-Luminosity Large Hadron Collider (HL-LHC) Preliminary Design Report

CERN Document Server

Apollinari, G; Béjar Alonso, I; Brüning, O; Lamont, M; Rossi, L

2015-01-01

The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community of about 7,000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its luminosity (rate of collisions) by a factor of five beyond the original design value and the integrated luminosity (total collisions created) by a factor ten. The LHC is already a highly complex and exquisitely optimised machine so this upgrade must be carefully conceived and will require about ten years to implement. The new configuration, known as High Luminosity LHC (HL-LHC), will rely on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11-12 tesla superconducting magnets, compact superconducting cav...

BPM Tolerances for HL-LHC Orbit Correction in the Inner Triplet Area

CERN Document Server

AUTHOR|(CDS)2075212

2015-01-01

For the HL-LHC beam spot sizes as small as 7 mum are considered for the high luminosity insertions IR1 and IR5. In addition, the luminosity has to be levelled over several hours by changing beta* resulting in constant changes of the optics and thus orbit changes. The small beam size and the continuous optics changes in general make the alignment of the beams at the IP challenging. In order to avoid continuous luminosity scans for the alignment of the beams at the IP, the orbit correction has to rely on the readings of the BPMs in the IT region. In this paper we review the requirements on resolution and accuracy of the BPMs and compare different options for the placement of the BPMs in the IT region

Time- and concentration-dependent effects of resveratrol in HL-60 and HepG2 cells

DEFF Research Database (Denmark)

Stervbo, Ulrik; Vang, Ole; Bonnesen, Christine

2006-01-01

Resveratrol, a phytochemical present in grapes, has been demonstrated to inhibit tumourigenesis in animal models. However, the specific mechanism by which resveratrol exerts its anticarcinogenic effect has yet to be elucidated. In the present study, the inhibitory effects of resveratrol on cell...... proliferation and apoptosis were evaluated in the human leukaemia cell line HL-60 and the human hepatoma derived cell line HepG2. We found that after a 2 h incubation period, resveratrol inhibited DNA synthesis in a concentration-dependent manner. The IC50 value was 15 μM in both HL-60 and HepG2 cells. When...... the time of treatment was extended, an increase in IC50 value was observed; for example, at 24 h the IC50 value was 30 μM for HL-60 cells and 60 μM for HepG2 cells. Flow cytometry revealed that cells accumulated in different phases of the cell cycle depending on the resveratrol concentration. Furthermore...

Optics of ion beams for the neutral beam injection system on HL-2A Tokamak

Energy Technology Data Exchange (ETDEWEB)

Zou, G. Q.; Lei, G. J.; Cao, J. Y.; Duan, X. R. [Southwestern Institute of Physics, Chengdu, 610041 (China)

2012-07-15

The ion beam optics for the neutral beam injection system on HL-2A Tokomak is studied by two- dimensional numerical simulation program firstly, where the emitting surface is taken at 100 Debye lengths from the plasma electrode. The mathematical formulation, computation techniques are described. Typical ion orbits, equipotential contours, and emittance diagram are shown. For a fixed geometry electrode, the effect of plasma density, plasma potential and plasma electron temperature on ion beam optics is examined, and the calculation reliability is confirmed by experimental results. In order to improve ion beam optics, the application of a small pre-acceleration voltage ({approx}100 V) between the plasma electrode and the arc discharge anode is reasonable, and a lower plasma electron temperature is desired. The results allow optimization of the ion beam optics in the neutral beam injection system on HL-2A Tokomak and provide guidelines for designing future neutral beam injection system on HL-2M Tokomak.

Optics of ion beams for the neutral beam injection system on HL-2A Tokamak.

Science.gov (United States)

Zou, G Q; Lei, G J; Cao, J Y; Duan, X R

2012-07-01

The ion beam optics for the neutral beam injection system on HL-2A Tokomak is studied by two- dimensional numerical simulation program firstly, where the emitting surface is taken at 100 Debye lengths from the plasma electrode. The mathematical formulation, computation techniques are described. Typical ion orbits, equipotential contours, and emittance diagram are shown. For a fixed geometry electrode, the effect of plasma density, plasma potential and plasma electron temperature on ion beam optics is examined, and the calculation reliability is confirmed by experimental results. In order to improve ion beam optics, the application of a small pre-acceleration voltage (∼100 V) between the plasma electrode and the arc discharge anode is reasonable, and a lower plasma electron temperature is desired. The results allow optimization of the ion beam optics in the neutral beam injection system on HL-2A Tokomak and provide guidelines for designing future neutral beam injection system on HL-2M Tokomak.

AN ORIGIN OF MULTIPLE RING STRUCTURE AND HIDDEN PLANETS IN HL TAU: A UNIFIED PICTURE BY SECULAR GRAVITATIONAL INSTABILITY

International Nuclear Information System (INIS)

Takahashi, Sanemichi Z.; Inutsuka, Shu-ichiro

2016-01-01

Recent ALMA observation has revealed multiple ring structures formed in a protoplanetary disk around HL Tau. Prior to the ALMA observation of HL Tau, theoretical analysis of secular gravitational instability (GI) described a possible formation of multiple ring structures with separations of 13 au around a radius of 100 au in protoplanetary disks under certain conditions. In this article, we reanalyze the viability of secular GI by adopting the physical values inferred from the observations. We derive the radial distributions of the most unstable wavelength and the growth timescale of secular GI and verify that secular GI can form the ring structures observed in HL Tau. When a turbulent viscosity coefficient α remains small in the inner region of the disk, secular GI grows in the whole disk. Thus, the formation of planetary mass objects should occur first in the inner region as a result of gravitational fragmentation after the nonlinear growth of secular GI. In this case, the resulting objects are expected to create gaps at r  ∼ 10 au and ∼30 au. As a result, all ring structures in HL Tau can be created by secular GI. If this scenario is realized in HL Tau, the outer region corresponds to the earlier growth phase of the most unstable mode of secular GI, and the inner region corresponds to the outcome of the nonlinear growth of secular GI. Therefore, this interpretation suggests that we are possibly witnessing both the beginning and the end of planet formation in HL Tau.

AN ORIGIN OF MULTIPLE RING STRUCTURE AND HIDDEN PLANETS IN HL TAU: A UNIFIED PICTURE BY SECULAR GRAVITATIONAL INSTABILITY

Energy Technology Data Exchange (ETDEWEB)

Takahashi, Sanemichi Z. [Astronomical Institute, Tohoku University, 6-3 Aoba, Aramaki-aza, Aoba-ku, Sendai, Miyagi (Japan); Inutsuka, Shu-ichiro, E-mail: sanemichi@astr.tohoku.ac.jp, E-mail: inutsuka@nagoya-u.jp [Department of Physics, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8602 (Japan)

2016-12-01

Recent ALMA observation has revealed multiple ring structures formed in a protoplanetary disk around HL Tau. Prior to the ALMA observation of HL Tau, theoretical analysis of secular gravitational instability (GI) described a possible formation of multiple ring structures with separations of 13 au around a radius of 100 au in protoplanetary disks under certain conditions. In this article, we reanalyze the viability of secular GI by adopting the physical values inferred from the observations. We derive the radial distributions of the most unstable wavelength and the growth timescale of secular GI and verify that secular GI can form the ring structures observed in HL Tau. When a turbulent viscosity coefficient α remains small in the inner region of the disk, secular GI grows in the whole disk. Thus, the formation of planetary mass objects should occur first in the inner region as a result of gravitational fragmentation after the nonlinear growth of secular GI. In this case, the resulting objects are expected to create gaps at r  ∼ 10 au and ∼30 au. As a result, all ring structures in HL Tau can be created by secular GI. If this scenario is realized in HL Tau, the outer region corresponds to the earlier growth phase of the most unstable mode of secular GI, and the inner region corresponds to the outcome of the nonlinear growth of secular GI. Therefore, this interpretation suggests that we are possibly witnessing both the beginning and the end of planet formation in HL Tau.

A guide for the laboratory information management system (LIMS) for light stable isotopes--Versions 7 and 8

Science.gov (United States)

Coplen, Tyler B.

2000-01-01

The reliability and accuracy of isotopic data can be improved by utilizing database software to (i) store information about samples, (ii) store the results of mass spectrometric isotope-ratio analyses of samples, (iii) calculate analytical results using standardized algorithms stored in a database, (iv) normalize stable isotopic data to international scales using isotopic reference materials, and (v) generate multi-sheet paper templates for convenient sample loading of automated mass-spectrometer sample preparation manifolds. Such a database program, the Laboratory Information Management System (LIMS) for Light Stable Isotopes, is presented herein. Major benefits of this system include (i) a dramatic improvement in quality assurance, (ii) an increase in laboratory efficiency, (iii) a reduction in workload due to the elimination or reduction of retyping of data by laboratory personnel, and (iv) a decrease in errors in data reported to sample submitters. Such a database provides a complete record of when and how often laboratory reference materials have been analyzed and provides a record of what correction factors have been used through time. It provides an audit trail for laboratories. LIMS for Light Stable Isotopes is available for both Microsoft Office 97 Professional and Microsoft Office 2000 Professional as versions 7 and 8, respectively. Both source code (mdb file) and precompiled executable files (mde) are available. Numerous improvements have been made for continuous flow isotopic analysis in this version (specifically 7.13 for Microsoft Access 97 and 8.13 for Microsoft Access 2000). It is much easier to import isotopic results from Finnigan ISODAT worksheets, even worksheets on which corrections for amount of sample (linearity corrections) have been added. The capability to determine blank corrections using isotope mass balance from analyses of elemental analyzer samples has been added. It is now possible to calculate and apply drift corrections to isotopic

Creating Flash advertising from concept to tracking-microsites, video ads and more

CERN Document Server

Fincanon, Jason

2007-01-01

Create awe-inspiring, mind-blowing Flash ads and microsites that engage consumers and demonstrate their worth to clients. The Hands-On Guide to Creating Flash Advertising delivers the nuts and bolts of the development process from initial design conception to ad completion. You'll learn the best practices for:* Mastering the myriad of ad specs, deadlines, quality and version control issues* Creating ads that balance campaign goals with design constraints* Preparing and building ads with team and QC standards* Using forms and data in ads without file bloat* File optimization techniques for swf

Reliability and validity of the korean version of the cornell scale for depression in dementia.

Science.gov (United States)

Lim, Hyun Kook; Hong, Seung Chul; Won, Wang Youn; Hahn, Changtae; Lee, Chang Uk

2012-12-01

The aim of this study was to explore the reliability and validity of the Korean version of the Cornell Scale for Depression in Dementia (CSDD-K), a scale for assessment of depression in dementia. The original CSDD was translated into Korean and the content was verified through back-translation procedures. This study included 59 depressive patients with Alzheimer's disease (AD), 62 non-depressive patients with AD and 36 healthy elderly controls. The subjects were assessed using CSDD-K, the 17-item Hamilton Depression Rating Scale (HAM-D(17)), the 15-item Korean version of Geriatric Depression Scale (GDS(15)) and the Korean version of Mini-mental Status Examination (MMSE-K). In the reliability test, Cronbach's α coefficient and test-retest reliabilities were 0.92 and 0.91, respectively, indicating that the CSDD-K has good internal consistency. There were significant differences in CSDD-K total scores between AD patients with depression and AD patients without depression (preliability and validity for the assessment of depressive symptom severity in AD patients. The CSDD-K is a useful instrument for assessing AD patients with depressive symptoms in Korean ethnic population.

Occurrence of ozone anomalies over cloudy areas in TOMS version-7 level-2 data

Directory of Open Access Journals (Sweden)

X. Liu

2003-01-01

Full Text Available This study investigates anomalous ozone distributions over cloudy areas in Nimbus-7 (N7 and Earth-Probe (EP TOMS version-7 data and analyzes the causes for ozone anomaly formation. A 5°-longitude by 5°-latitude region is defined to contain a Positive Ozone Anomaly (POA or Negative Ozone Anomaly (NOA if the correlation coefficient between total ozone and reflectivity is > 0.5 or -0.5. The average fractions of ozone anomalies among all cloud fields are 31.8 ± 7.7% and 35.8 ± 7.7% in the N7 and EP TOMS data, respectively. Some ozone anomalies are caused by ozone retrieval errors, and others are caused by actual geophysical phenomena. Large cloud-height errors are found in the TOMS version-7 algorithm in comparison to the Temperature Humidity Infrared Radiometer (THIR cloud data. On average, cloud-top pressures are overestimated by ~200 hPa (THIR cloud-top pressure 200 hPa for high-altitude clouds and underestimated by ~150 hPa for low-altitude clouds (THIR cloud-top pressure > 750 hPa. Most tropical NOAs result from negative errors induced by large cloud-height errors, and most tropical POAs are caused by positive errors due to intra-cloud ozone absorption enhancement. However, positive and negative errors offset each other, reducing the ozone anomaly occurrence in TOMS data. Large ozone/reflectivity slopes for mid-latitude POAs show seasonal variation consistent with total ozone fluctuation, indicating that they result mainly from synoptic and planetary wave disturbances. POAs with an occurrence fraction of 30--60% occur in regions of marine stratocumulus off the west coast of South Africa and off the west coast of South America. Both fractions and ozone/reflectivity slopes of these POAs show seasonal variations consistent with that in the tropospheric ozone. About half the ozone/reflectivity slope can be explained by ozone retrieval errors over clear and cloudy areas. The remaining slope may result from there being more ozone production

The Natural Antiangiogenic Compound AD0157 Induces Caspase-Dependent Apoptosis in Human Myeloid Leukemia Cells

Directory of Open Access Journals (Sweden)

Melissa García-Caballero

2017-11-01

Full Text Available Evasion of apoptosis is a hallmark of cancer especially relevant in the development and the appearance of leukemia drug resistance mechanisms. The development of new drugs that could trigger apoptosis in aggressive hematological malignancies, such as AML and CML, may be considered a promising antileukemic strategy. AD0157, a natural marine pyrrolidinedione, has already been described as a compound that inhibits angiogenesis by induction of apoptosis in endothelial cells. The crucial role played by defects in the apoptosis pathways in the pathogenesis, progression and response to conventional therapies of several forms of leukemia, moved us to analyze the effect of this compound on the growth and death of leukemia cells. In this work, human myeloid leukemia cells (HL60, U937 and KU812F were treated with AD0157 ranging from 1 to 10 μM and an experimental battery was applied to evaluate its apoptogenic potential. We report here that AD0157 was highly effective to inhibit cell growth by promotion of apoptosis in human myeloid leukemia cells, and provide evidence of its mechanisms of action. The apoptogenic activity of AD0157 on leukemia cells was verified by an increased chromatin condensation and DNA fragmentation, and confirmed by an augmentation in the apoptotic subG1 population, translocation of the membrane phosphatidylserine from the inner face of the plasma membrane to the cell surface and by cleavage of the apoptosis substrates PARP and lamin-A. In addition, AD0157 in the low micromolar range significantly enhanced the activities of the initiator caspases-8 and -9, and the effector caspases-3/-7 in a dose-dependent manner. Results presented here throw light on the apoptogenic mechanism of action of AD0157, mediated through caspase-dependent cascades, with an especially relevant role played by mitochondria. Altogether, these results suggest the therapeutic potential of this compound for the treatment of human myeloid leukemia.

Fast pattern recognition with the ATLAS L1 track trigger for the HL-LHC

CERN Document Server

Martensson, Mikael; The ATLAS collaboration

2016-01-01

A fast hardware based track trigger for high luminosity upgrade of the Large Hadron Collider (HL- LHC) is being developed in ATLAS. The goal is to achieve trigger levels in high pileup collisions that are similar or even better than those achieved at low pile-up running of LHC by adding tracking information to the ATLAS hardware trigger which is currently based on information from calorimeters and muon trigger chambers only. Two methods for fast pattern recognition are investigated. The first is based on matching tracker hits to pattern banks of simulated high momentum tracks which are stored in a custom made Associative Memory (AM) ASIC. The second is based on the Hough transform where detector hits are transformed into 2D Hough space with one variable related to track pt and one to track direction. Hits found by pattern recognition will be sent to a track fitting step which calculates the track parameters . The speed and precision of the track fitting depends on the quality of the hits selected by the patte...

GRAIN SIZE CONSTRAINTS ON HL TAU WITH POLARIZATION SIGNATURE

International Nuclear Information System (INIS)

Kataoka, Akimasa; Dullemond, Cornelis P; Muto, Takayuki; Momose, Munetake; Tsukagoshi, Takashi

2016-01-01

The millimeter-wave polarization of the protoplanetary disk around HL Tau has been interpreted as the emission from elongated dust grains aligned with the magnetic field in the disk. However, the self-scattering of thermal dust emission may also explain the observed millimeter-wave polarization. In this paper, we report a modeling of the millimeter-wave polarization of the HL Tau disk with the self-polarization. Dust grains are assumed to be spherical and to have a power-law size distribution. We change the maximum grain size with a fixed dust composition in a fixed disk model to find the grain size to reproduce the observed signature. We find that the direction of the polarization vectors and the polarization degree can be explained with the self-scattering. Moreover, the polarization degree can be explained only if the maximum grain size is ∼150 μm. The obtained grain size from the polarization is different from that which has been previously expected from the spectral index of the dust opacity coefficient (a millimeter or larger) if the emission is optically thin. We discuss that porous dust aggregates may solve the inconsistency of the maximum grain size between the two constraints

GRAIN SIZE CONSTRAINTS ON HL TAU WITH POLARIZATION SIGNATURE

Energy Technology Data Exchange (ETDEWEB)

Kataoka, Akimasa; Dullemond, Cornelis P [Zentrum für Astronomie der Universität Heidelberg, Institut für Theoretische Astrophysik, Albert-Ueberle-Str. 2, D-69120 Heidelberg (Germany); Muto, Takayuki [Division of Liberal Arts, Kogakuin University, 1-24-2 Nishi-Shinjuku, Shinjuku-ku, Tokyo 163-8677 (Japan); Momose, Munetake; Tsukagoshi, Takashi, E-mail: kataoka@uni-heidelberg.de [College of Science, Ibaraki University, 2-1-1 Bunkyo, Mito, Ibaraki 310-8512 (Japan)

2016-03-20

The millimeter-wave polarization of the protoplanetary disk around HL Tau has been interpreted as the emission from elongated dust grains aligned with the magnetic field in the disk. However, the self-scattering of thermal dust emission may also explain the observed millimeter-wave polarization. In this paper, we report a modeling of the millimeter-wave polarization of the HL Tau disk with the self-polarization. Dust grains are assumed to be spherical and to have a power-law size distribution. We change the maximum grain size with a fixed dust composition in a fixed disk model to find the grain size to reproduce the observed signature. We find that the direction of the polarization vectors and the polarization degree can be explained with the self-scattering. Moreover, the polarization degree can be explained only if the maximum grain size is ∼150 μm. The obtained grain size from the polarization is different from that which has been previously expected from the spectral index of the dust opacity coefficient (a millimeter or larger) if the emission is optically thin. We discuss that porous dust aggregates may solve the inconsistency of the maximum grain size between the two constraints.

Current and expected performance of tracking and vertexing with the ATLAS detector at the LHC and the HL-LHC.

CERN Document Server

Kastanas, Alex; The ATLAS collaboration

2018-01-01

The ATLAS detector at the Large Hadron Collider (LHC) has had an extremely successful data collecting period during 2017, recording over 45 fb-1 of proton-proton collision data at sqrt(s) = 13 TeV. This was achieved, in part, by running the LHC at a high instantaneous lumi- nosity level of over 1.5 x 10+34 cm-2s-1, which corresponds to over 57 inelastic proton-proton collisions per beam crossing. This talk will highlight the tracking and vertexing performance of the tracking detector within ATLAS (Inner Detector) throughout this successful year of data taking. In order to increase its potential for discoveries, the High Luminosity Large Hadron Collider (HL-LHC) aims to increase the LHC data-set by an order of magnitude by collecting 3,000 fb-1 of recorded data. Starting, from mid-2026, the HL-LHC is expected to reach the peak instantaneous luminosity of 7.5 x 10+34 cm-2s-1, which corresponds to about 200 inelastic proton-proton collisions per beam crossing. To cope with the large radiation doses and high pile...

A study on apoptotic signaling pathway in HL-60 cells induced by radiation

International Nuclear Information System (INIS)

Kim, Hye Jung; Moon, Sung Keun; Lee, Jae Hoon; Moon, Sun Rock

2001-01-01

The mechanical insights of death at cancer cells by ionizing radiation are not yet clearly defined. Recent evidences have demonstrated that radiation therapy may induce cell death via activation of signaling pathway for apoptosis in target cells. This study is designed whether ionizing radiation may activate the signaling cascades of apoptosis including caspase family cysteine proteases, Bcl2/Bax, cytochrome c and Fas/Fas-L in target cells. HL-60 cells were irradiated in vitro with 6 MV X-ray at dose ranges from 2 Gy to 32 Gy. The cell viability was tested by MTT assay and the extent of apoptosis was determined using agarose gel electrophoresis. The activities of caspase proteases were measured by proteolytic cleavages of substrates. Western blot analysis was used to monitor PARP, caspase-3, Cytochrome-c, BcI-2, Bax, Fas and Fas-L. Ionizing radiation decreases the viability of HL -60 cells in a time and dose dependent manner. Ionizing radiation-induced death in HL- 60 cells is an apoptotic death which is revealed as characteristic ladder-pattern fragmentation at genomic DNA over 16 Gy at 4 hours. Ionizing radiation induces the activation of caspase-2, 3, 6, 8 and 9 of HL --60 cells in a time-dependent manner. The activation of caspase- 3 protease is also evidenced by the digestion of poly (ADP-ribose) polymerase and procaspase 3 with 16Gy ionizing irradiation. Anti-apoptotic Bcl2 expression is decreased but apoptotic Bax expression is increased with mitochondrial cytochrome c release in a time- dependent manner. In addition, expression of Fas and Fas-L is also increased in a time dependent manner. These data suggest that ionizing radiation-induced apoptosis is mediated by the activation of various signaling pathways including caspase family cysteine proteases, BcI 2 /Bax, Fas and Fas-L in a time and dose dependent manner

Validation of a cutoff for the Depression Scale of the Center for Epidemiologic Studies, Brief Version (CESD-7.

Directory of Open Access Journals (Sweden)

Aarón Salinas-Rodríguez

2013-05-01

Full Text Available Objective. To evaluate the Depression Scale of the Center for Epidemiologic Studies, Brief Version (CESD-7 psychometric properties in Mexican adult population, and validate a cutoff for classifying subjects according to the presence / absence of clinically significant depressive symptoms (CSDS. Materials and methods. Screening cross-sectional study with a subsample of 301 adult residents of the Morelos state in Mexico, originally interviewed for the National Survey of Health and Nutrition 2012. Sensitivity and specificity of the selected cutoff were estimated using as reference the diagnostic criteria of ICD-10 and DSM-IV. Results. The cutoff point estimated was CESD-7=9. Using the ICD-10 the sensitivity and specificity were 90.2 and 86%, and ROC was 88%. Using DSM-IV, the values were 80.4, 89.6, and 85%, respectively. Conclusions. The short version of the CESD-7 has good psychometric properties and can be used as a screening test to identify probable cases of subjects with clinically significant depressive symptoms.

Neutral pressure measured by fast ionization gauge in HL-2A

International Nuclear Information System (INIS)

Wang, M.X.; Yan, L.W.; Hong, W.Y.; Cui, Z.Y.; Pan, Y.D.; Yao, L.H.; Cao, Z.; Yang, Q.W.; Liu, Y.

2007-01-01

A fast ionization gauge capable of working in a strong magnetic field and noisy environment is developed for the pressure measurement in the main chamber and the divertor chamber of the HL-2A tokamak. The neutral pressure in the main chamber evidently decreases after in-situ siliconization. Improvement of boundary plasma confinement is observed with SMBI or PI fueling after siliconization. The neutral pressure in the main chamber for divertor configuration is 50% lower than that for limiter one. The pressure in the divertor chamber rises when the strike point moves toward the bottom of the vertical target plates. The maximum pressure compression of is 24. The relative high pressure in the main chamber is contributed primarily by plasma limiter interaction due to the short distance from separatrix to limiter and secondly by neutral flux from the divertor chamber to the main chamber by leaks in HL-2A

Characterization of a receptor for interleukin-5 on human eosinophils and the myeloid leukemia line HL-60

International Nuclear Information System (INIS)

Ingley, E.; Young, I.G.

1991-01-01

Interleukin-5 (IL-5) promotes the growth and differentiation of human eosinophils and may regulate the selective eosinophilia and eosinophil activation seen in certain diseases. Radiolabeled recombinant human IL-5 (hIL-5) was used to characterize the IL-5 receptor present on normal human eosinophils and on the myeloid leukemia line HL-60, which can be induced to differentiate into eosinophilic cells. Binding studies with eosinophils and HL-60 cells grown under alkaline conditions demonstrated similar high-affinity binding sites for hIL-5 on both cell types with kd values of approximately 400 pmol/L. The binding observed was specific in that it was not inhibited by hIL-3, human granulocyte-macrophage colony-stimulating factor, or hIL-2. Binding studies with a number of other human cell lines, including a B-lymphoma line, and with lymphocyte and neutrophil preparations were also performed, but IL-5 receptors were not detectable on these cells. The number of hIL-5 receptors on HL-60 cells could be correlated with its propensity to differentiate towards an eosinophilic cell type. Expression of hIL-5 receptors on HL-60 cells was upregulated by butyric acid under alkaline conditions, downregulated by hIL-3, virtually eliminated by dimethyl sulfoxide and hIL-5, while hIL-2 had no detectable effect. One major 125I-hIL-5-crosslinked complex of 75 to 85 Kd in Mr was detected on HL-60 cells using crosslinking agents giving a molecular mass of 55 to 60 Kd for the hIL-5 receptor itself. Studies using cellular autoradiography showed that IL-5 receptors were evenly distributed on eosinophils but that receptor distribution on HL-60 cells was noticeably heterogeneous. Eosinophils were the only cells in slides prepared from peripheral blood that had detectable levels of IL-5 receptors in agreement with the specific action of IL-5 on the human eosinophil lineage

External cephalic version-related risks: a meta-analysis.

Science.gov (United States)

Grootscholten, Kim; Kok, Marjolein; Oei, S Guid; Mol, Ben W J; van der Post, Joris A

2008-11-01

To systematically review the literature on external cephalic version-related complications and to assess if the outcome of a version attempt is related to complications. In March 2007 we searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials. Studies reporting on complications from an external cephalic version attempt for singleton breech pregnancies after 36 weeks of pregnancy were selected. We calculated odds ratios (ORs) from studies that reported both on complications as well as on the position of the fetus immediately after the procedure. We found 84 studies, reporting on 12,955 version attempts that reported on external cephalic version-related complications. The pooled complication rate was 6.1% (95% CI 4.7-7.8), 0.24% for serious complications (95% confidence interval [CI] 0.17-0.34) and 0.35% for emergency cesarean deliveries (95% CI 0.26-0.47). Complications were not related to external cephalic version outcome (OR 1.2 (95% CI 0.93-1.7). External cephalic version is a safe procedure. Complications are not related to the fetal position after external cephalic version.

Involvement of the histamine H{sub 4} receptor in clozapine-induced hematopoietic toxicity: Vulnerability under granulocytic differentiation of HL-60 cells

Energy Technology Data Exchange (ETDEWEB)

Goto, Aya; Mouri, Akihiro; Nagai, Tomoko; Yoshimi, Akira; Ukigai, Mako; Tsubai, Tomomi; Hida, Hirotake [Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503 (Japan); Ozaki, Norio [Department of Psychiatry, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550 (Japan); Noda, Yukihiro, E-mail: ynoda@meijo-u.ac.jp [Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503 (Japan)

2016-09-01

Clozapine is an effective antipsychotic for treatment-resistant schizophrenia, but can cause fatal hematopoietic toxicity as agranulocytosis. To elucidate the mechanism of hematopoietic toxicity induced by clozapine, we developed an in vitro assay system using HL-60 cells, and investigated the effect on hematopoiesis. HL-60 cells were differentiated by all-trans retinoic acid (ATRA) into three states according to the following hematopoietic process: undifferentiated HL-60 cells, those undergoing granulocytic ATRA-differentiation, and ATRA-differentiated granulocytic cells. Hematopoietic toxicity was evaluated by analyzing cell survival, cell proliferation, granulocytic differentiation, apoptosis, and necrosis. In undifferentiated HL-60 cells and ATRA-differentiated granulocytic cells, both clozapine (50 and 100 μM) and doxorubicin (0.2 µM) decreased the cell survival rate, but olanzapine (1–100 µM) did not. Under granulocytic differentiation for 5 days, clozapine, even at a concentration of 25 μM, decreased survival without affecting granulocytic differentiation, increased caspase activity, and caused apoptosis rather than necrosis. Histamine H{sub 4} receptor mRNA was expressed in HL-60 cells, whereas the expression decreased under granulocytic ATRA-differentiation little by little. Both thioperamide, a histamine H{sub 4} receptor antagonist, and DEVD-FMK, a caspase-3 inhibitor, exerted protection against clozapine-induced survival rate reduction, but not of live cell counts. 4-Methylhistamine, a histamine H{sub 4} receptor agonist, decreased the survival rate and live cell counts, as did clozapine. HL-60 cells under granulocytic differentiation are vulnerable under in vitro assay conditions to hematopoietic toxicity induced by clozapine. Histamine H{sub 4} receptor is involved in the development of clozapine-induced hematopoietic toxicity through apoptosis, and may be a potential target for preventing its occurrence through granulocytic differentiation

Assessment of RELAP5/MOD3 Version 7 based on the BETHSY Test 6.2 TC

International Nuclear Information System (INIS)

Choi, C.J.; Roth, P.A.; Schultz, R.R.

1992-01-01

This document provides a discussion of the BETHSY test 6.2 TC which was conducted to investigate thermal hydraulic phenomena during a 5% cold leg SBLOCA and to provide high quality data for advanced thermal-hydraulic code assessment. BETHSY test 6.2 TC was analyzed using RELAP5/MOD3 version 7o

Upgrade Plans for ATLAS Forward Calorimetry for the HL-LHC

CERN Document Server

Krieger, P; The ATLAS collaboration

2013-01-01

The ATLAS detector was designed and built to study proton-proton (pp) collisions produced by the Large Hadron Collider (LHC) at centre-of-mass energies up to 14 TeV and instantaneous luminosities up to $10^{34}{\\rm cm}^{-2}{\\rm s}^{-1}$. At the higher instantaneous luminosity ($5\\times 10^{34}{\\rm cm}^{-2}{\\rm s}^{-1}$) proposed for the High-Luminosity LHC (HL-LHC), some components of ATLAS will not operate properly, while others may not survive the dose that will be accumulated while collecting the proposed 3000 fb$^{-1}$ of pp collision data. For the ATLAS liquid argon (LAr) calorimeter, problems are anticipated in the forward region where the particle flux is particularly high. The existing Forward Calorimeter (FCal) was designed with very narrow LAr gaps (250-500 $\\mu$m) in order to avoid problems due to ion build-up that would distort the electric field. At HL-LHC luminosities, these gaps are no longer sufficiently narrow. The resulting distortions of the electric field in the gaps would be exacerbated b...

Expected performance of the upgrade ATLAS experiment for HL-LHC

CERN Document Server

Liu, Peilian; The ATLAS collaboration

2018-01-01

The Large Hadron Collider (LHC) has been successfully delivering proton-proton collision data at the unprecedented center of mass energy of 13 TeV. An upgrade is planned to increase the instantaneous luminosity delivered by the LHC in what is called the HL-LHC, aiming to deliver a total of up 3000/fb to 4000/fb of data per experiment. To cope with the expected data-taking conditions ATLAS is planning major upgrades of the detector. It is now a critical time for these upgrade projects and during the last year and a half, six Technical Design Reports (TDR) were produced by the ATLAS Collaboration. In these TDRs the physics motivation and benefits of such upgrades are discussed together with details on the upgrade project itself. In this contribution we review the expected performance of the upgraded ATLAS detector and the expected reach for physics measurements as well as the discovery potential for new physics that is expected by the end of the HL-LHC data-taking. The performance of object reconstruction under...

Upgrade plans for ATLAS Forward Calorimetry for the HL-LHC

CERN Document Server

Turner, J; The ATLAS collaboration

2011-01-01

Even though data taking has just started with the LHC, plans are being developed to operate the machine and its detectors at up to 10 times the original design luminosity. This has an impact on many components of the ATLAS detector, particularly the Forward calorimeter, which is exposed to some of the highest radiation rates in ATLAS. The FCal detector and its associated components were designed for operation at the maximum LHC luminosity of 1034 cm2s-1. However at the higher luminosities (HL), which are projected for the HL-LHC, operation of the FCal will be compromised. Beam heating in the FCal which is located on a liquid argon filled cryostat could lead to the formation of argon bubbles in the detector, the ionization rate will result in space charge effects that will reduce the signal and the current draw will result in a voltage drop across the HV current limiting resistors. The space charge and ionization rates will result in the FCal becoming insensitive to particles at its inner edge and the insensit...

Upgrade Plans for ATLAS Forward Calorimetry for the HL-LHC

CERN Document Server

Turner, J

2012-01-01

Even though data-taking has just started with the LHC, plans are being developed to operate the machine and its detectors at up to 10 times the original design luminosity. This has a major impact on the Forward Calorimeter (FCal), which is exposed to some of the highest radiation rates in ATLAS. The FCal detector and its associated components were designed for operation at the maximum LHC luminosity of \\(\\text{10}^{\\text{34}} \\text{ cm}^{-2}\\text{s}^{-1}\\). However at the higher luminosities projected for the HL-LHC, operation of the FCal may be compromised. Beam heating in the FCal could lead to the formation of argon bubbles in the detector, the ionization rate will result in space charge effects that will reduce the signal and the current draw will result in a voltage drop across the HV current limiting resistors. Two possible solutions are being considered to maintain FCal operation at HL-LHC. One is a complete replacement of the FCal system. A replacement FCal would have a similar design to the current c...

Upgrade Plans for ATLAS Forward Calorimetry for the HL-LHC

CERN Document Server

Fincke-Keeler, M; The ATLAS collaboration

2012-01-01

Although LHC data-taking is expected to continue for a number or years, plans are already being developed for operation of the LHC and associated detectors at a increased instantaneous luminosity about 5 times the original design value of 10^34 cm^-2 s^-1. The increased particle flux at this high luminosity (HL) will have an impact on many sub-systems of the ATLAS detector. In particular, in the LAr forward calorimeter (FCal), which was designed for operation at LHC luminosities, the associated increase in the ionization load at HL-LHC luminosities poses a number of problems that can degrade its performance, related to beam heating, space charge effects in the LAr gaps and HV losses due to increased current draws over the HV current-limiting resistors. One solution to these problems, which would require the opening of both endcap cryostats, is the construction and installation of a new FCal, with cooling loops, narrower LAr gaps, and lower value protection resistors. A second proposed solution, which does not...

Antismoking Ads at the Point of Sale: The Influence of Ad Type and Context on Ad Reactions.

Science.gov (United States)

Kim, Annice; Nonnemaker, James; Guillory, Jamie; Shafer, Paul; Parvanta, Sarah; Holloway, John; Farrelly, Matthew

2017-06-01

Efforts are underway to educate consumers about the dangers of smoking at the point of sale (POS). Research is limited about the efficacy of POS antismoking ads to guide campaign development. This study experimentally tests whether the type of antismoking ad and the context in which ads are viewed influence people's reactions to the ads. A national convenience sample of 7,812 adult current smokers and recent quitters was randomized to 1 of 39 conditions. Participants viewed one of the four types of antismoking ads (negative health consequences-graphic, negative social consequences-intended emotive, benefits of quitting-informational, benefits of quitting-graphic) in one of the three contexts (alone, next to a cigarette ad, POS tobacco display). We assessed participants' reactions to the ads, including perceived effectiveness, negative emotion, affective dissonance, and motivational reaction. Graphic ads elicited more negative emotion and affective dissonance than benefits of quitting ads. Graphic ads elicited higher perceived effectiveness and more affective dissonance than intended emotive ads. Antismoking ads fared best when viewed alone, and graphic ads were least influenced by the context in which they were viewed. These results suggest that in developing POS campaigns, it is important to consider the competitive pro-tobacco context in which antismoking ads will be viewed.

1D and 2D assembly structures by imidazole···chloride hydrogen bonds of iron(II) complexes [Fe(II)(HL(n-Pr))3]Cl·Y (HL(n-Pr) = 2-methylimidazol-4-yl-methylideneamino-n-propyl; Y = AsF6, BF4) and their spin states.

Science.gov (United States)

Fujinami, Takeshi; Nishi, Koshiro; Matsumoto, Naohide; Iijima, Seiichiro; Halcrow, Malcolm A; Sunatsuki, Yukinari; Kojima, Masaaki

2011-12-07

Two Fe(II) complexes fac-[Fe(II)(HL(n-Pr))(3)]Cl·Y (Y = AsF(6) (1) and BF(4) (2)) were synthesized, where HL(n-Pr) is 2-methylimidazole-4-yl-methylideneamino-n-propyl. Each complex-cation has the same octahedral N(6) geometry coordinated by three bidentate ligands and assumes facial-isomerism, fac-[Fe(II)(HL(n-Pr))(3)](2+) with Δ- and Λ-enantiomorphs. Three imidazole groups per Δ- or Λ-fac-[Fe(II)(HL(n-Pr))(3)](2+) are hydrogen-bonded to three Cl(-) ions or, from the viewpoint of the Cl(-) ion, one Cl(-) ion is hydrogen-bonded to three neighbouring fac-[Fe(II)(HL(n-Pr))(3)](2+) cations. The 3 : 3 NH···Cl(-) hydrogen bonds between Δ- or Λ-fac-[Fe(II)(HL(n-Pr))(3)](2+) and Cl(-) generate two kinds of assembly structures. The directions of the 3 : 3 NH···Cl(-) hydrogen bonds and hence the resulting assembly structures are determined by the size of the anion Y, though Y is not involved into the network structure and just accommodated in the cavity. Compound 1 has a 1D ladder structure giving a larger cavity, in which the Δ- and Λ-fac-[Fe(II)(HL(n-Pr))(3)](2+) enantiomorphs are bridged by two NH···Cl(-) hydrogen bonds. Compound 2 has a 2D network structure with a net unit of a cyclic trimer of {fac-[Fe(II)(HL(n-Pr))(3)](2+)···Cl(-)}(3) giving a smaller cavity, in which Δ- or Λ-fac-[Fe(II)(HL(n-Pr))(3)](2+) species with the same chirality are linked by NH···Cl(-) hydrogen bonds to give a homochiral 2D network structure. Magnetic susceptibility and Mössbauer spectral measurements demonstrated that compound 1 showed an abrupt one-step spin crossover with 4.0 K thermal hysteresis of T(c↓) = 125.5 K and T(c↑) = 129.5 K and compound 2 showed no spin transition and stayed in the high-spin state over the 5-300 K temperature range.

Vacuum currents in braneworlds on AdS bulk with compact dimensions

Science.gov (United States)

Bellucci, S.; Saharian, A. A.; Vardanyan, V.

2015-11-01

The two-point function and the vacuum expectation value (VEV) of the current density are investigated for a massive charged scalar field with arbitrary curvature coupling in the geometry of a brane on the background of AdS spacetime with partial toroidal compactification. The presence of a gauge field flux, enclosed by compact dimensions, is assumed. On the brane the field obeys Robin boundary condition and along compact dimensions periodicity conditions with general phases are imposed. There is a range in the space of the values for the coefficient in the boundary condition where the Poincaré vacuum is unstable. This range depends on the location of the brane and is different for the regions between the brane and AdS boundary and between the brane and the horizon. In models with compact dimensions the stability condition is less restrictive than that for the AdS bulk with trivial topology. The vacuum charge density and the components of the current along non-compact dimensions vanish. The VEV of the current density along compact dimensions is a periodic function of the gauge field flux with the period equal to the flux quantum. It is decomposed into the boundary-free and brane-induced contributions. The asymptotic behavior of the latter is investigated near the brane, near the AdS boundary and near the horizon. It is shown that, in contrast to the VEVs of the field squared an denergy-momentum tensor, the current density is finite on the brane and vanishes for the special case of Dirichlet boundary condition. Both the boundary-free and brane-induced contributions vanish on the AdS boundary. The brane-induced contribution vanishes on the horizon and for points near the horizon the current is dominated by the boundary-free part. In the near-horizon limit, the latter is connected to the corresponding quantity for a massless field in the Minkowski bulk by a simple conformal relation. Depending on the value of the Robin coefficient, the presence of the brane can either

New Physics at HL-LHC with ATLAS

CERN Document Server

Rosten, Rachel; The ATLAS collaboration

2018-01-01

The prospects for new physics at the luminosity upgrade of LHC, HL-LHC, with a data set equivalent to 3000 fb-1, simulated in the upgrade ATLAS detector, are presented and discussed. Benchmark studies are presented to show how the sensitivity improves at the future high-luminosity LHC runs. Prospects for searches for new heavy bosons and dark matter candidates at 14 TeV pp collisions are explored, as well as the sensitivity of searches for anomalous top decays. For all these studies, a parameterised simulation of the upgraded ATLAS detector response is used, taking into account the expected pileup conditions.

Higher brightness beams from the SPS for the HL-LHC era

CERN Document Server

AUTHOR|(CDS)2085448; Bracco, Chiara (CERN)

The need to push the LHC beyond its limits and increase the deliverable luminosity to the experiments by about one order of magnitude has driven the ongoing injector and HL-LHC upgrades. The higher luminosity requires to increase the beam brightness, which directly translates in the need to adapt the different machine protection systems. Among all the foreseen upgrades, the transfer line collimators (TCDI) and the LHC injection protection systems will be revised. In particular, the guaranteed protection is evaluated in this Ph D work, together with the specification for the minimum shielded aperture in case of injection failures. A detailed model is also developed which insures a more reliable and efficient procedure for the validation of the TCDI setup within the required accuracy. The physics beyond colliders will also be pushed over its current limits in the HL-LHC era. SHiP, a new proposed fixed target experiment served by the SPS is under study. The unprecedented level of requested protons on target per ...

Searches for electroweak SUSY with ATLAS at HL-LHC

CERN Document Server

Amoroso, Simone; The ATLAS collaboration

2018-01-01

The High Luminosity-Large Hadron Collider (HL-LHC) is expected to start in 2026 and to pro- vide an integrated luminosity of 3000 fb$^{−1}$ in ten years, a factor 10 more than what will be collected by 2023. This high statistics will allow ATLAS to improve searches for new physics at the TeV scale. In this talk search prospects for the electroweak production of supersymmetric particles are presented.

“Value Added Taxes, Chain Effects and Informality”, Second Version

OpenAIRE

Aureo de Paula; Jose A. Scheinkman

2009-01-01

This paper investigates determinants of informal economic activity. We present an equilibrium model of informality and test its implications using a survey of 48,000+ small firms in Brazil. We define informality as tax avoidance; firms in the informal sector avoid tax payments but suffer other limitations. A novel theoretical contribution in this model is the role of value added taxes in transmitting informality. It predicts that the informality of a firm is correlated to the informality of f...

Evaluation of the Hydrolab HL4 water-quality sonde and sensors

Science.gov (United States)

Snazelle, Teri T.

2017-12-18

The U.S. Geological Survey (USGS) Hydrologic Instrumentation Facility evaluated three Hydrolab HL4 multiparameter water-quality sondes by OTT Hydromet. The sondes were equipped with temperature, conductivity, pH, dissolved oxygen (DO), and turbidity sensors. The sensors were evaluated for compliance with the USGS National Field Manual for the Collection of Water-Quality Data (NFM) criteria for continuous water-quality monitors and to verify the validity of the manufacturer’s technical specifications. The conductivity sensors were evaluated for the accuracy of the specific conductance (SC) values (conductance at 25 degrees Celsius [oC]), that were calculated by using the vendor default method, Hydrolab Fresh. The HL4’s communication protocols and operating temperature range along with accuracy of the water-quality sensors were tested in a controlled laboratory setting May 1–19, 2016. To evaluate the sonde’s performance in a surface-water field application, an HL4 equipped with temperature, conductivity, pH, DO, and turbidity sensors was deployed June 20–July 22, 2016, at USGS water-monitoring site 02492620, Pearl River at National Space Technology Laboratories (NSTL) Station, Mississippi, located near Bay Saint Louis, Mississippi, and compared to the adjacent well-maintained EXO2 site sonde.The three HL4 sondes met the USGS temperature testing criteria and the manufacturer’s technical specifications for temperature based upon the median room temperature difference between the measured and standard temperatures, but two of the three sondes exceeded the allowable difference criteria at the temperature extremes of approximately 5 and 40 ºC. Two sondes met the USGS criteria for SC. One of the sondes failed the criteria for SC when evaluated in a 100,000-microsiemens-per-centimeter (μS/cm) standard at room temperature, and also failed in a 10,000-μS/cm standard at 5, 15, and 40 ºC. All three sondes met the USGS criteria for pH and DO at room temperature

A Highly Selective First-Level Muon Trigger With MDT Chamber Data for ATLAS at HL-LHC

CERN Document Server

INSPIRE-00390105

2016-07-11

Highly selective triggers are essential for the physics programme of the ATLAS experiment at HL-LHC where the instantaneous luminosity will be about an order of magnitude larger than the LHC instantaneous luminosity in Run 1. The first level muon trigger rate is dominated by low momentum muons below the nominal trigger threshold due to the moderate momentum resolution of the Resistive Plate and Thin Gap trigger chambers. The resulting high trigger rates at HL-LHC can be su?ciently reduced by using the data of the precision Muon Drift Tube chambers for the trigger decision. This requires the implementation of a fast MDT read-out chain and of a fast MDT track reconstruction algorithm with a latency of at most 6 microseconds. A hardware demonstrator of the fast read-out chain has been successfully tested at the HL-LHC operating conditions at the CERN Gamma Irradiation Facility. The fast track reconstruction algorithm has been implemented on a fast trigger processor.

A Highly Selective First-Level Muon Trigger With MDT Chamber Data for ATLAS at HL-LHC

CERN Document Server

Nowak, Sebastian; The ATLAS collaboration

2015-01-01

Highly selective triggers are essential for the physics programme of the ATLAS experiment at HL-LHC where the instantaneous luminosity will be about an order of magnitude larger than the LHC design luminosity. The Level-1 muon trigger rate is dominated by low momentum muons below the nominal trigger threshold due to the limited momentum resolution of the Resistive Plate and Thin Gap trigger chambers. The resulting high trigger rates at HL-LHC can be sufficient reduced by using the data of the precision Muon Drift Tube chambers for the trigger decision. This requires the implementation of a fast MDT read-out chain and of a fast MDT track reconstruction algorithm with a latency of at most 6~$\\mu$s. A hardware demonstrator of the fast read-out chain has been successfully tested at the high HL-LHC background rates at the CERN Gamma Irradiation Facility. The fast track reconstruction algorithm has been implemented on a fas trigger processor.

Rare Coumarins Induce Apoptosis, G1 Cell Block and Reduce RNA Content in HL60 Cells

Directory of Open Access Journals (Sweden)

Widelski Jarosław

2017-02-01

Full Text Available The rare coumarins stenocarpin, stenocarpin isobutyrate, oficinalin, oficinalin isobutyrate, 8-methoxypeucedanin and the known xanthotoxin, isoimperatorin, bergapten, peucedanin and 8–methoxyisoimperatorin were isolated from Peucedanum luxurians Tamamsch. (Apiaceae and identified by means of spectral data (1D and 2D NMR. Their immunomodulating activity was evaluated by flow cytometry and their influence on HL60 cells as well as on PHA-stimulated PBLs was tested. All tested coumarins induce apoptosis (maximal in the 48 h culture and decrease cell proliferation in a time- and dose-dependent manner, especially in HL60 cells. They also induce partial G1 block, but only in HL60 cells (at 100 µM concentrations. Dose-dependent reduction of RNA content was also found in G1 cells treated by the coumarins. All of the tested coumarins also possessed immunomodulatory activities. Bergapten and xanthotoxin were found to be the best candidates for further evaluation as anti-cancer drugs.

Radiation oncology systems integration

International Nuclear Information System (INIS)

Ragan, D.P.

1991-01-01

ROLE7 is intended as a complementary addition to the HL7 Standard and not as an alternative standard. Attempt should be made to mould data elements which are specific to radiation therapy with existing HL7 elements. This can be accomplished by introducing additional values to some element's table-of-options. Those elements which might be specific to radiation therapy could from new segments to be added to the Ancillary Data Reporting set. In order to accomplish ROLE7, consensus groups need be formed to identify the various functions related to radiation oncology that might motivate information exchange. For each of these functions, the specific data elements and their format must be identified. HL7 is organized with a number of applications which communicate asynchronously. Implementation of ROLE7 would allow uniform access to information across vendors and functions. It would provide improved flexibility in system selection. It would allow a more flexible and affordable upgrade path as systems in radiation oncology improve. (author). 5 refs

B-physics studies for HL-LHC ATLAS upgrade

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00236452; The ATLAS collaboration

2017-01-01

Performance studies are made to estimate the ATLAS potential in $B$-physics after upgrade for Run2 and HL-LHC. Real data as well as Monte Carlo simulations are used to study the decay of $B^0_s \\to J/\\psi\\phi$ in order to measure the $CP$ violating mixing phase and the width difference between the $B^0_s$ eigenstates. The increased sensitivity is expected mainly due to the improved decay time resolution obtained with the upgraded IBL and ITk inner tracking detector.

The reliability and validity of the Turkish version of the Neuropsychiatric Inventory-Clinician.

Science.gov (United States)

Sahin Cankurtaran, Eylem; Danişman, Mustafa; Tutar, Hasan; Ulusoy Kaymak, Semra

2015-01-01

The Neuropsychiatric Inventory-Clinician (NPI-C) scale is one of the best-known scales for evaluating the behavioral and psychological symptoms of dementia. This study aimed to assess the reliability and validity of the Turkish version of the NPI-C scale in patients with Alzheimer disease (AD). The NPI-C scale was administered to 125 patients with AD. For reliability, both Cronbach's α and interrater reliability were analyzed. The Behavioral Pathology in Alzheimer's Disease (BEHAVE-AD) scale was applied for validity and, in addition, the Mini Mental State Examination (MMSE), Instrumental Activities of Daily Living (IADL) scale, and Disability Assessment of Dementia (DAD) scale were completed. The Turkish version of the NPI-C scale showed high internal consistency (Cronbach's α = 0.75) and mostly good interrater reliability. Assessments of validity showed that the NPI-C and corresponding BEHAVE-AD domains were found to be significantly correlated, between 0.925 and 0.195. Moreover, the correlations between NPI-C and MMSE were significant for all domains except the dysphoria, anxiety, and elation/euphoria domains. When we conducted a correlation analysis of NPI-C with IADL, all domains were statistically significantly correlated except aggression, anxiety, elation/euphoria, and dysphoria. The Turkish version of the NPI-C scale was found to be a reliable and valid instrument to assess neuropsychiatric symptoms in Turkish elderly subjects with AD.

Pre- and post-processing of TORT data and preliminary experience with TORT version 3

International Nuclear Information System (INIS)

Hoogenboom, J.E.; John, T.M.; Hersman, A.; Leege, P.F.A. de

1997-01-01

As the cross-section input to the TORT 3-D transport code is very rigid, subroutines have been included in the local version of TORT to process other cross-section libraries. A mixing table routine was added in order to prepare macroscopic cross-sections from microscopic cross-section libraries. Post-processing was added through additional output flux files in the CCCC-format together with the GEODST file describing the geometry. Recently the new TORT version 3 was successfully installed. However, many problems had to be solved to properly extract the source code and documentation from the UNIX script delivered with the code package. Preliminary tests did not show big differences in performance with the older version. (R.P.)

The ATLAS liquid argon calorimeter: upgrade plans for the HL-LHC

CERN Document Server

Novgorodova, Olga; The ATLAS collaboration

2015-01-01

The ATLAS detector was designed and built to study proton-proton collisions produced at the LHC at centre-of-mass energies up to 14 TeV and instantaneous luminosities up to 10$^{34}$ cm$^{-2}$s$^{-1}$. Liquid argon (LAr) sampling calorimeters are employed for electromagnetic and hadronic calorimetry. The LAr has to withstand a High Luminosity LHC (HL-LHC) operation of the collider and associated detectors at luminosities of up to (5-7)$\\times$10$^{34}$ cm$^{-2}$s$^{-1}$, with the goal of accumulating an integrated luminosity of 3000 fb$^{-1}$. This is well beyond the values for which the detectors were designed. The electromagnetic and hadronic calorimeters will be able to tolerate the increased particle flux, but the performance of the forward calorimeter (FCal) will be affected. Two possible solutions for keeping the current performance are being discussed. The electronics readout will also need to withstand a 3-5 times larger radiation environment. In the hadronic endcap calorimeter (HEC) cold GaAs preampl...

Psychometric properties of the Chinese-version Quality of Nursing Work Life Scale.

Science.gov (United States)

Lee, Ya-Wen; Dai, Yu-Tzu; McCreary, Linda L; Yao, Grace; Brooks, Beth A

2014-09-01

In this study, we developed and tested the psychometric properties of the Chinese-version Quality of Nursing Work Life Scale along seven subscales: supportive milieu with security and professional recognition, work arrangement and workload, work/home life balance, head nurse's/supervisor's management style, teamwork and communication, nursing staffing and patient care, and milieu of respect and autonomy. An instrument-development procedure with three phases was conducted in seven hospitals in 2010-2011. Phase I comprised translation and the cultural-adaptation process, phase II comprised a pilot study, and phase III comprised a field-testing process. Purposive sampling was used in the pilot study (n = 150) and the large field study (n = 1254). Five new items were added, and 85.7% of the original items were retained in the 41 item Chinese version. Principal component analysis revealed that a model accounted for 56.6% of the variance with acceptable internal consistency, concurrent validity, and discriminant validity. This study gave evidence of reliability and validity of the 41 item Chinese-version Quality of Nursing Work Life Scale. © 2014 Wiley Publishing Asia Pty Ltd.

Feedback control of plasma position in the HL-1 tokamak

International Nuclear Information System (INIS)

Yuan Baoshan; Jiao Boliang; Yang Kailing

1991-01-01

In the HL-1 tokamak with a thick copper shell, the control of plasma position is successfully performed by a feedback-feedforward system with dual mode regulator and the equilibrium field coils outside the shell. The plasma position can be controlled within ±2 mm in both vertical and horizontal directions under the condition that the iron core of transformer is not saturated

Rhein triggers apoptosis via induction of endoplasmic reticulum stress, caspase-4 and intracellular calcium in primary human hepatic HL-7702 cells

Energy Technology Data Exchange (ETDEWEB)

KoraMagazi, Arouna [Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu (China); Wang, Dandan [Department of Pharmacology, China Pharmaceutical University, Nanjing, Jiangsu (China); Yousef, Bashir; Guerram, Mounia [Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu (China); Yu, Feng, E-mail: yufengcpu14@yahoo.com [Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu (China); Department of Pharmacology, China Pharmaceutical University, Nanjing, Jiangsu (China); Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing, Jiangsu (China)

2016-04-22

Rhein is an active component of rhubarb; a traditional Chinese medicine reported to induce apoptosis and cause liver toxicity. However, rhein's apoptotic-inducing effects, as well as its molecular mechanisms of action on hepatic cells need to be further explored. In the present study, rhein was found to trigger apoptosis in primary human hepatic HL-7702 cells as showed by annexin V/PI double staining assay and nuclear morphological changes demonstrated by Hoechst 33258 staining. Moreover, it was observed that the mechanism implicated in rhein-induced apoptosis was caspase-dependent, presumably via ER-stress associated pathways, as illustrated by up-regulation of glucose-regulated protein 78 (GRP 78), PKR-like ER kinase (PERK), C-Jun N-terminal kinase (JNK) and CCAAT/enhancer-binding protein homologous protein (CHOP). Meanwhile, caspase-4 as a hallmark of ER-stress, was also showed to be activated following by caspase-3 activation. Furthermore, rhein also promoted intracellular elevation of calcium that contributed in apoptosis induction. Interestingly, pre-treatment with calpain inhibitor I reduced the effects of rhein on apoptosis induction and JNK activation. These data suggested that rhein-induced apoptosis through ER-stress and elevated intracellular calcium level in HL-7702 cells. - Highlights: • Rhein triggers apoptotic cell death on primary human hepatic HL-7702 cells. • Rhein leads to caspase-4 activation in HL-7702 cells. • Rhein induces endoplasmic reticulum stress pathways in HL-7702 cells. • Rhein causes elevation of intracellular calcium concentrations in HL-7702 cells.

Non-equilibrium scalar two point functions in AdS/CFT

International Nuclear Information System (INIS)

Keränen, Ville; Kleinert, Philipp

2015-01-01

In the first part of the paper, we discuss different versions of the AdS/CFT dictionary out of equilibrium. We show that the Skenderis-van Rees prescription and the “extrapolate” dictionary are equivalent at the level of “in-in” two point functions of free scalar fields in arbitrary asymptotically AdS spacetimes. In the second part of the paper, we calculate two point correlation functions in dynamical spacetimes using the “extrapolate” dictionary. These calculations are performed for conformally coupled scalar fields in examples of spacetimes undergoing gravitational collapse, the AdS 2 -Vaidya spacetime and the AdS 3 -Vaidya spacetime, which allow us to address the problem of thermalization following a quench in the boundary field theory. The computation of the correlators is formulated as an initial value problem in the bulk spacetime. Finally, we compare our results for AdS 3 -Vaidya to results in the previous literature obtained using the geodesic approximation and we find qualitative agreement.

Snake perturbations during pellet injection and LHCD in the HL-1M tokamak

International Nuclear Information System (INIS)

Liu Yi; Qiu Xiaoming; Dong Yunbo; Zhong Yunzhe; Fu Bingzhong; Jiafu Dong Yong Liu

2005-01-01

Excitation of snake perturbations has been observed in the core region of pellet-fuelled HL-1M plasmas when the pellets cross surface with q value 1. Through measurements of plasma q profile by means of multi-exposures with CCD camera during pellet ablation, and investigation on pellet ablation process, possible mechanisms for the formation of snake oscillation are discussed. In addition, a large, long-lived snake-like oscillation is frequently observed in lower hybrid current driven discharge in which the sawtooth has been stabilized at early times. There is evidence that such a perturbation is due to impurity accumulation during sawtooth-stabilization, and the good performance with peaking profiles after LHCD is limited by magnetohydrodynamic (MHD) instabilities including sawtooth and snake activities in HL-1M plasma. (author)

TRIM32 promotes retinoic acid receptor α-mediated differentiation in human promyelogenous leukemic cell line HL60

International Nuclear Information System (INIS)

Sato, Tomonobu; Okumura, Fumihiko; Iguchi, Akihiro; Ariga, Tadashi; Hatakeyama, Shigetsugu

2012-01-01

Highlights: ► TRIM32 enhanced RARα-mediated transcriptional activity even in the absence of RA. ► TRIM32 stabilized RARα in the human promyelogenous leukemic cell line HL60. ► Overexpression of TRIM32 in HL60 cells induced granulocytic differentiation. ► TRIM32 may function as a coactivator for RARα-mediated transcription in APL cells. -- Abstract: Ubiquitination, one of the posttranslational modifications, appears to be involved in the transcriptional activity of nuclear receptors including retinoic acid receptor α (RARα). We previously reported that an E3 ubiquitin ligase, TRIM32, interacts with several important proteins including RARα and enhances transcriptional activity of RARα in mouse neuroblastoma cells and embryonal carcinoma cells. Retinoic acid (RA), which acts as a ligand to nuclear receptors including RARα, plays crucial roles in development, differentiation, cell cycles and apoptosis. In this study, we found that TRIM32 enhances RARα-mediated transcriptional activity even in the absence of RA and stabilizes RARα in the human promyelogenous leukemic cell line HL60. Moreover, we found that overexpression of TRIM32 in HL60 cells suppresses cellular proliferation and induces granulocytic differentiation even in the absence of RA. These findings suggest that TRIM32 functions as one of the coactivators for RARα-mediated transcription in acute promyelogenous leukemia (APL) cells, and thus TRIM32 may become a potentially therapeutic target for APL.

Calculation of Wakefields and Higher Order Modes for the Vacuum Chamber of the ATLAS Experiment for the HL-LHC

CERN Document Server

Wanzenberg, R

2013-01-01

A design study for a High Luminosity Large Hadron Collider (HL-LHC) was started to extend the discovery potential of the Large Hadron Collider (LHC). The HL-LHC study implies also an upgraded configuration of the ATLAS detector with a new beam pipe. The trapped Higher Order Modes (HOMs) and the short range wakefields for the new design of the vacuum chamber are calculated using the computer codes MAFIA and ECHO2D. The short range wakefields are characterized in terms of kick and loss parameters. For the HOMs the frequency the R/Q and the Q-values are given which can directly converted into impedance data. The obtained data are intended to be included into the impedance database of the HL-LHC.

Dose- and Time-Dependent Response of Human Leukemia (HL-60 Cells to Arsenic Trioxide Treatment

Directory of Open Access Journals (Sweden)

Paul B. Tchounwou

2006-06-01

Full Text Available The treatment of acute promyelocytic leukemia (APL has been based on the administration of all-trans retinoic acid plus anthracycline chemotherapy, which is very effective as first line therapy; however 25 to 30% of patients will relapse with their disease becoming refractory to conventional therapy. Recently, studies have shown arsenic trioxide to be effective in the treatment of acute promyelocytic leukemia. In this study, we used the human leukemia (HL-60 cell line as a model to evaluate the cytoxicity of arsenic trioxide based on the MTT assay. Data obtained from this assay indicated that arsenic trioxide significantly reduced the viability of HL-60 cells, showing LD50 values of 14.26 + 0.5μg/mL, 12.54 + 0.3μg/mL, and 6.4 + 0.6μg/mL upon 6, 12, and 24 hours of exposure, respectively; indicating a dose- and time-dependent response relationship. Findings from the present study indicate that arsenic trioxide is highly cytotoxic to human leukemia (HL-60 cells, supporting its use as an effective therapeutic agent in the management of acute promyelocytic leukemia.

Light water reactor fuel analysis code FEMAXI-7. Model and structure

International Nuclear Information System (INIS)

Suzuki, Motoe; Udagawa, Yutaka; Nagase, Fumihisa; Saitou, Hiroaki

2013-07-01

A light water reactor fuel analysis code FEMAXI-7 has been developed for the purpose of analyzing the fuel behavior in both normal conditions and anticipated transient conditions. This code is an advanced version which has been produced by incorporating the former version FEMAXI-6 with numerous functional improvements and extensions. In FEMAXI-7, many new models have been added and parameters have been clearly arranged. Also, to facilitate effective maintenance and accessibility of the code, modularization of subroutines and functions have been attained, and quality comment descriptions of variables or physical quantities have been incorporated in the source code. With these advancements, the FEMAXI-7 code has been upgraded to a versatile analytical tool for high burnup fuel behavior analyses. This report describes in detail the design, basic theory and structure, models and numerical method of FEMAXI-7, and its improvements and extensions. (author)

Effects of highly ripened cheeses on HL-60 human leukemia cells: antiproliferative activity and induction of apoptotic DNA damage.

Science.gov (United States)

Yasuda, S; Ohkura, N; Suzuki, K; Yamasaki, M; Nishiyama, K; Kobayashi, H; Hoshi, Y; Kadooka, Y; Igoshi, K

2010-04-01

To establish cheese as a dairy product with health benefits, we examined the multifunctional role of cheeses. In this report, we clarify whether different types of commercial cheeses may possess antiproliferative activity using HL-60 human promyelocytic leukemia cell lines as a cancer model. Among 12 cheese extracts tested, 6 (Montagnard, Pont-l'Eveque, Brie, Camembert, Danablue, and Blue) revealed strong growth inhibition activity and induction of DNA fragmentation in HL-60 cells. Based on the quantification of nitrogen contents in different cheese samples, a positive correlation between the ripeness of various cheeses and their antiproliferative activity tested in HL-60 cells was displayed. Four varieties of Blue cheese ripened for 0, 1, 2, or 3 mo demonstrated that the Blue cheese ripened for a long term was capable of causing the strong suppression of the cell growth and the induction of apoptotic DNA damage as well as nucleic morphological change in HL-60 cells. Collectively, these results obtained suggest a potential role of highly ripened cheeses in the prevention of leukemic cell proliferation. Copyright (c) 2010 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells.

Science.gov (United States)

Liu, Jie; Malavya, Swati; Wang, Xueqian; Saavedra, Joseph E; Keefer, Larry K; Tokar, Erik; Qu, Wei; Waalkes, Michael P; Shami, Paul J

2009-07-01

The nitric oxide (NO) prodrug JS-K is shown to have anticancer activity. To profile the molecular events associated with the anticancer effects of JS-K, HL-60 leukemia cells were treated with JS-K and subjected to microarray and real-time RT-PCR analysis. JS-K induced concentration- and time-dependent gene expression changes in HL-60 cells corresponding to the cytolethality effects. The apoptotic genes (caspases, Bax, and TNF-alpha) were induced, and differentiation-related genes (CD14, ITGAM, and VIM) were increased. For acute phase protein genes, some were increased (TP53, JUN) while others were suppressed (c-myc, cyclin E). The expression of anti-angiogenesis genes THBS1 and CD36 and genes involved in tumor cell migration such as tissue inhibitors of metalloproteinases, were also increased by JS-K. Confocal analysis confirmed key gene changes at the protein levels. Thus, multiple molecular events are associated with JS-K effects in killing HL-60, which could be molecular targets for this novel anticancer NO prodrug.

Proposed FPGA based tracking for a Level-1 track trigger at CMS for the HL-LHC

CERN Document Server

Pozzobon, Nicola

2014-01-01

The High Luminosity LHC (HL-LHC) is expected to deliver a luminosity in excess of $5\\times10^{34}$ cm$^{-2}$/s. The high event rate places stringent requirements on the trigger system. A key component of the CMS upgrade for the HL-LHC is a track trigger system which will identify tracks with transverse momenta above 2 GeV already at the first-level trigger within 5 $\\mu$s. This presentation will discuss a proposed track finding and fitting based on the tracklet based approach implemented on FPGAs. Tracklets are formed from pairs of hits in nearby layers in the detector and used in a road search. Summary Fast pattern recognition in Silicon trackers for triggering has often made use of Associative Memories for the pattern recognition step. We propose an alternative approach to solving the pattern recognition and track fitting problem for the upgraded CMS tracker for the HL-LHC operation. We make use of the trigger primitives,stubs, from the tracker. The stubs are formed from pairs of hits in sensors separated r...

Gravitational perturbation of the BTZ black hole induced by test particles and weak cosmic censorship in AdS spacetime

International Nuclear Information System (INIS)

Rocha, Jorge V.; Cardoso, Vitor

2011-01-01

We analyze the gravitational perturbations induced by particles falling into a three dimensional, asymptotically AdS black hole geometry. More specifically, we solve the linearized perturbation equations obtained from the geodesic motion of a ringlike distribution of test particles in the BTZ background. This setup ensures that the U(1) symmetry of the background is preserved. The nonasymptotic flatness of the background raises difficulties in attributing the significance of energy and angular momentum to the conserved quantities of the test particles. This issue is well known but, to the best of our knowledge, has never been addressed in the literature. We confirm that the naive expressions for energy and angular momentum are the correct definitions. Finally, we put an asymptotically AdS version of the weak cosmic censorship to a test: by attempting to overspin the BTZ black hole with test particles it is found that the black hole cannot be spun-up past its extremal limit.

Upgrade plans for the ATLAS Forward Calorimeter at the HL-LHC

CERN Document Server

Rutherfoord, J; The ATLAS collaboration

2012-01-01

Although data-taking at CERN's Large Hadron Collider (LHC) is expected to continue for a number of years, plans are already being developed for operation of the LHC and associated detectors at an increased instantaneous luminosity about 5 times the original design value of 10^34 cm^-2 s^-1. The increased particle flux at this high luminosity (HL) will have an impact on many sub-systems of the ATLAS detector. In particular, in the liquid argon forward calorimeter (FCal), which was designed for operation at LHC luminosities, the associated increase in the ionization load at HL-LHC luminosities creates a number of problems which can degrade its performance. These include space-charge effects in the liquid argon gaps, excessive drop in potential across the gaps due to large HV supply currents through the protection resistors, and an increase in temperature which may cause the liquid argon to boil. One solution, which would require opening both End-Cap cryostats, is the construction and installation of new FCals w...

Enabling Technologies for Silicon Microstrip Tracking Detectors at the HL-LHC

CERN Document Server

Barth, C; Bloch, I.; Bögelspacher, F.; de Boer, W.; Daniels, M.; Dierlamm, A.; Eber, R.; Eckerlin, G.; Eckstein, D.; Eichhorn, T.; Erfle, J.; Feld, L.; Garutti, E.; Gregor, I. -M.; Guthoff, M.; Hartmann, F.; Hauser, M.; Husemann, U.; Jakobs, K.; Junkes, A.; Karpinski, W.; Klein, K.; Kuehn, S.; Lacker, H.; Mahboubi, K.; Müller, Th.; Mussgiller, A.; Nürnberg, A.; Parzefall, U.; Poehlsen, T.; Poley, L.; Preuten, M.; Rehnisch, L.; Sammet, J.; Schleper, P.; Schuwalow, S.; Sperlich, D.; Stanitzki, M.; Steinbrück, G.; Wlochal, M.

2016-01-01

While the tracking detectors of the ATLAS and CMS experiments have shown excellent performance in Run 1 of LHC data taking, and are expected to continue to do so during LHC operation at design luminosity, both experiments will have to exchange their tracking systems when the LHC is upgraded to the high-luminosity LHC (HL-LHC) around the year 2024. The new tracking systems need to operate in an environment in which both the hit densities and the radiation damage will be about an order of magnitude higher than today. In addition, the new trackers need to contribute to the first level trigger in order to maintain a high data-taking efficiency for the interesting processes. Novel detector technologies have to be developed to meet these very challenging goals. The German groups active in the upgrades of the ATLAS and CMS tracking systems have formed a collaborative "Project on Enabling Technologies for Silicon Microstrip Tracking Detectors at the HL-LHC" (PETTL), which was supported by the Helmholtz Alliance "Phys...

Upgrade plans for the ATLAS Forward Calorimeter at the HL-LHC

CERN Document Server

Rutherfoord, J; The ATLAS collaboration

2012-01-01

Although LHC data-taking is expected to continue for a number of years, plans are already being developed for operation of the LHC and associated detectors at an increased instantaneous luminosity about 5 times the original design value of 10^34 cm^-2 s^-1. The increased particle flux at this high luminosity (HL) will have an impact on many sub-systems of the ATLAS detector. In particular, in the LAr forward calorimeter (FCal), which was designed for operation at LHC luminosities, the associated increase in the ionization load at HL-LHC luminosities poses a number of problems that can degrade its performance, related to beam heating, space charge effects in the LAr gaps and HV losses due to increased current draws over the HV current-limiting resistors. One solution to the problems, which would require the opening of both endcap cryostats, is the construction and installation of a new FCal, with cooling loops, narrower LAr gaps, and lower value protection resistors. A second proposed solution, which does not ...

A Forward Silicon Strip System for the ATLAS HL-LHC Upgrade

CERN Document Server

Wonsak, S; The ATLAS collaboration

2012-01-01

The LHC is successfully accumulating luminosity at a centre-of-mass energy of 8 TeV this year. At the same time, plans are rapidly progressing for a series of upgrades, culminating roughly eight years from now in the High Luminosity LHC (HL-LHC) project. The HL-LHC is expected to deliver approximately five times the LHC nominal instantaneous luminosity, resulting in a total integrated luminosity of around 3000 fb-1 by 2030. The ATLAS experiment has a rather well advanced plan to build and install a completely new Inner Tracker (IT) system entirely based on silicon detectors by 2020. This new IT will be made from several pixel and strip layers. The silicon strip detector system will consist of single-sided p-type detectors with five barrel layers and six endcap (EC) disks on each forward side. Each disk will consist of 32 trapezoidal objects dubbed “petals”, with all services (cooling, read-out, command lines, LV and HV power) integrated into the petal. Each petal will contain 18 silicon sensors grouped in...

Light water reactor fuel analysis code FEMAXI-7; model and structure

International Nuclear Information System (INIS)

Suzuki, Motoe; Udagawa, Yutaka; Saitou, Hiroaki

2011-03-01

A light water reactor fuel analysis code FEMAXI-7 has been developed for the purpose of analyzing the fuel behavior in both normal conditions and anticipated transient conditions. This code is an advanced version which has been produced by incorporating the former version FEMAXI-6 with numerous functional improvements and extensions. In FEMAXI-7, many new models have been added and parameters have been clearly arranged. Also, to facilitate effective maintenance and accessibility of the code, modularization of subroutines and functions have been attained, and quality comment descriptions of variables or physical quantities have been incorporated in the source code. With these advancements, the FEMAXI-7 code has been upgraded to a versatile analytical tool for high burnup fuel behavior analyses. This report describes in detail the design, basic theory and structure, models and numerical method, and improvements and extensions. (author)

Annexin A7 deficiency potentiates cardiac NFAT activity promoting hypertrophic signaling

International Nuclear Information System (INIS)

Voelkl, Jakob; Alesutan, Ioana; Pakladok, Tatsiana; Viereck, Robert; Feger, Martina; Mia, Sobuj; Schönberger, Tanja; Noegel, Angelika A.; Gawaz, Meinrad; Lang, Florian

2014-01-01

Highlights: • Cardiac Anxa7 expression was up-regulated following TAC. • The hypertrophic response following TAC was augmented in Anxa7-deficient mice. • Silencing of Anxa7 increased indicators of HL-1 cardiomyocytes hypertrophy. • Silencing of Anxa7 induced Nfatc1 nuclear translocation. • Silencing of Anxa7 enhanced NFAT-dependent transcriptional activity. - Abstract: Annexin A7 (Anxa7) is a cytoskeletal protein interacting with Ca 2+ signaling which in turn is a crucial factor for cardiac remodeling following cardiac injury. The present study explored whether Anxa7 participates in the regulation of cardiac stress signaling. To this end, mice lacking functional Anxa7 (anxa7 −/− ) and wild-type mice (anxa7 +/+ ) were investigated following pressure overload by transverse aortic constriction (TAC). In addition, HL-1 cardiomyocytes were silenced with Anxa7 siRNA and treated with isoproterenol. Transcript levels were determined by quantitative RT-PCR, transcriptional activity by luciferase reporter assay and protein abundance by Western blotting and confocal microscopy. As a result, TAC treatment increased the mRNA and protein levels of Anxa7 in wild-type mice. Moreover, TAC increased heart weight to body weight ratio and the cardiac mRNA levels of αSka, Nppb, Col1a1, Col3a1 and Rcan1, effects more pronounced in anxa7 −/− mice than in anxa7 +/+ mice. Silencing of Anxa7 in HL-1 cardiomyocytes significantly increased nuclear localization of Nfatc1. Furthermore, Anxa7 silencing increased NFAT-dependent transcriptional activity as well as αSka, Nppb, and Rcan1 mRNA levels both, under control conditions and following β-adrenergic stimulation by isoproterenol. These observations point to an important role of annexin A7 in the regulation of cardiac NFAT activity and hypertrophic response following cardiac stress conditions

Annexin A7 deficiency potentiates cardiac NFAT activity promoting hypertrophic signaling

Energy Technology Data Exchange (ETDEWEB)

Voelkl, Jakob; Alesutan, Ioana; Pakladok, Tatsiana; Viereck, Robert; Feger, Martina; Mia, Sobuj [Department of Physiology, University of Tübingen, Tübingen (Germany); Schönberger, Tanja [Department of Cardiology and Cardiovascular Medicine, University of Tübingen, Tübingen (Germany); Noegel, Angelika A. [Center for Biochemistry, Institute of Biochemistry I, University of Cologne, Köln (Germany); Gawaz, Meinrad [Department of Cardiology and Cardiovascular Medicine, University of Tübingen, Tübingen (Germany); Lang, Florian, E-mail: florian.lang@uni-tuebingen.de [Department of Physiology, University of Tübingen, Tübingen (Germany)

2014-02-28

Highlights: • Cardiac Anxa7 expression was up-regulated following TAC. • The hypertrophic response following TAC was augmented in Anxa7-deficient mice. • Silencing of Anxa7 increased indicators of HL-1 cardiomyocytes hypertrophy. • Silencing of Anxa7 induced Nfatc1 nuclear translocation. • Silencing of Anxa7 enhanced NFAT-dependent transcriptional activity. - Abstract: Annexin A7 (Anxa7) is a cytoskeletal protein interacting with Ca{sup 2+} signaling which in turn is a crucial factor for cardiac remodeling following cardiac injury. The present study explored whether Anxa7 participates in the regulation of cardiac stress signaling. To this end, mice lacking functional Anxa7 (anxa7{sup −/−}) and wild-type mice (anxa7{sup +/+}) were investigated following pressure overload by transverse aortic constriction (TAC). In addition, HL-1 cardiomyocytes were silenced with Anxa7 siRNA and treated with isoproterenol. Transcript levels were determined by quantitative RT-PCR, transcriptional activity by luciferase reporter assay and protein abundance by Western blotting and confocal microscopy. As a result, TAC treatment increased the mRNA and protein levels of Anxa7 in wild-type mice. Moreover, TAC increased heart weight to body weight ratio and the cardiac mRNA levels of αSka, Nppb, Col1a1, Col3a1 and Rcan1, effects more pronounced in anxa7{sup −/−} mice than in anxa7{sup +/+} mice. Silencing of Anxa7 in HL-1 cardiomyocytes significantly increased nuclear localization of Nfatc1. Furthermore, Anxa7 silencing increased NFAT-dependent transcriptional activity as well as αSka, Nppb, and Rcan1 mRNA levels both, under control conditions and following β-adrenergic stimulation by isoproterenol. These observations point to an important role of annexin A7 in the regulation of cardiac NFAT activity and hypertrophic response following cardiac stress conditions.

Overexpression of the Large-Conductance, Ca2+-Activated K+ (BK) Channel Shortens Action Potential Duration in HL-1 Cardiomyocytes.

Science.gov (United States)

Stimers, Joseph R; Song, Li; Rusch, Nancy J; Rhee, Sung W

2015-01-01

Long QT syndrome is characterized by a prolongation of the interval between the Q wave and the T wave on the electrocardiogram. This abnormality reflects a prolongation of the ventricular action potential caused by a number of genetic mutations or a variety of drugs. Since effective treatments are unavailable, we explored the possibility of using cardiac expression of the large-conductance, Ca2+-activated K+ (BK) channel to shorten action potential duration (APD). We hypothesized that expression of the pore-forming α subunit of human BK channels (hBKα) in HL-1 cells would shorten action potential duration in this mouse atrial cell line. Expression of hBKα had minimal effects on expression levels of other ion channels with the exception of a small but significant reduction in Kv11.1. Patch-clamped hBKα expressing HL-1 cells exhibited an outward voltage- and Ca2+-sensitive K+ current, which was inhibited by the BK channel blocker iberiotoxin (100 nM). This BK current phenotype was not detected in untransfected HL-1 cells or in HL-1 null cells sham-transfected with an empty vector. Importantly, APD in hBKα-expressing HL-1 cells averaged 14.3 ± 2.8 ms (n = 10), which represented a 53% reduction in APD compared to HL-1 null cells lacking BKα expression. APD in the latter cells averaged 31.0 ± 5.1 ms (n = 13). The shortened APD in hBKα-expressing cells was restored to normal duration by 100 nM iberiotoxin, suggesting that a repolarizing K+ current attributed to BK channels accounted for action potential shortening. These findings provide initial proof-of-concept that the introduction of hBKα channels into a cardiac cell line can shorten APD, and raise the possibility that gene-based interventions to increase hBKα channels in cardiac cells may hold promise as a therapeutic strategy for long QT syndrome.

Preliminary Study of Ideal Operational MHD Beta Limit in HL-2A Tokamak Plasmas

International Nuclear Information System (INIS)

Shen Yong; Dong Jiaqi; He Hongda; Turnbull, A. D.

2009-01-01

Magnetohydrodynamic (MHD) n = 1 kink mode with n the toroidal mode number is studied and the operational beta limit, constrained by the mode, is calculated for the equilibrium of HL-2A by using the GATO code. Approximately the same beta limit is obtained for configurations with a value of the axial safety factor q 0 both larger and less than 1. Without the stabilization of the conducting wall, the beta limit is found to be 0.821% corresponding to a normalized beta value of β c N = 2.56 for a typical HL-2A discharge with a plasma current I p = 0.245 MA, and the scaling of β c N ∼constant is confirmed. (magnetically confined plasma)

Improved response function calculations for scintillation detectors using an extended version of the MCNP code

CERN Document Server

Schweda, K

2002-01-01

The analysis of (e,e'n) experiments at the Darmstadt superconducting electron linear accelerator S-DALINAC required the calculation of neutron response functions for the NE213 liquid scintillation detectors used. In an open geometry, these response functions can be obtained using the Monte Carlo codes NRESP7 and NEFF7. However, for more complex geometries, an extended version of the Monte Carlo code MCNP exists. This extended version of the MCNP code was improved upon by adding individual light-output functions for charged particles. In addition, more than one volume can be defined as a scintillator, thus allowing the simultaneous calculation of the response for multiple detector setups. With the implementation of sup 1 sup 2 C(n,n'3 alpha) reactions, all relevant reactions for neutron energies E sub n <20 MeV are now taken into consideration. The results of these calculations were compared to experimental data using monoenergetic neutrons in an open geometry and a sup 2 sup 5 sup 2 Cf neutron source in th...

Sensor R&D for the CMS Tracker Upgrade for the HL-LHC

CERN Document Server

Behnamian, Hadi

2014-01-01

At an instantaneous luminosity of $5\\times 10^{34} cm^{-2} s^{-1}$, the high-luminosity phase of the Large Hadron Collider (HL-LHC) is expected to deliver a total of 3000 $fb^{-1}$ of collisions, hereby increasing the discovery potential of the LHC experiments significantly. However, the radiation environment of the tracking system will be severe, requiring new radiation hard sensors for the CMS tracker. The CMS tracker collaboration has almost completed a large material investigation and irradiation campaign to identify the silicon material and design that fulfills all requirements of a new tracking detector at HL-LHC. Focusing on the upgrade of the outer tracker region, pad diodes as well as fully functional strip sensors have been implemented on silicon wafers with different material properties and thicknesses. The samples were irradiated with a mixture of neutrons and protons corresponding to fluences as expected for various positions in the future tracker. The measurements performed on the structures inc...

Reliability Analysis of Corroded Reinforced Concrete Beams Using Enhanced HL-RF Method

Directory of Open Access Journals (Sweden)

Arash Mohammadi Farsani

2015-12-01

Full Text Available Steel corrosion of bars in concrete structures is a complex process which leads to the reduction of the cross-section bars and decreasing the resistance of the concrete and steel materials. In this study, reliability analysis of a reinforced concrete beam with corrosion defects under the distributed load was investigated using the enhanced Hasofer-Lind and Rackwitz-Fiessler (EHL-RF method based on relaxed approach. Robustness of the EHL-RF algorithm was compared with the HL-RF using a complicated example. It was seen that the EHL-RF algorithm is more robust than the HL-RF method. Finally, the effects of corrosion time were investigated using the EHL-RF algorithm for a reinforced concrete beam based on flexural strength in the pitting and general corrosion. The model uncertainties were considered in the resistance and load terms of flexural strength limit state function. The results illustrated that increasing the corrosion time-period leads to increase in the failure probability of the corroded concrete beam.

Operationalization of the Russian Version of Highly Sensitive Person Scale

Directory of Open Access Journals (Sweden)

Регина Вячеславовна Ершова

2018-12-01

Full Text Available The aim of the present study was to operationalize a Russian version of the Highly Sensitive Person Scale (HSPS. The empirical data were collected in two ways: active, through oral advertising and inviting those who wish to take part in the study (snowball technique and passive (placement of ads about taking part in a research in social networks VKontakte and Facebook. As a result, 350 university students (117 men, 233 women, an average age of 18,2 (± 1,7 applied to a research laboratory and filled out the HSPS questionnaire, and another 510 respondents (380 women, 130 men, average age 22,6 ( ± 7,9 filled the HSPS online. The results of the study did not confirm the one-dimensional model of the construct, proposed by Aron & Aron (1997, as well as the most commonly used in the English-language studies three-factor solution. The hierarchical claster and confirmatory analyses used in the operationalization procedure allowed us to conclude that the variance of the Russian version of HSPS is best described in the framework of a two-factor model including the two separate subscales: Ease of Excitation (EOE, Low threshold of sensitivity (LTS. Sensory Processing Sensitivity may be defined as an increased susceptibility to external and internal stimuli, realized through negative emotional responses and deep susceptibility (distress to excessive stimulation.

Injection Protection Upgrade for the HL-LHC

CERN Document Server

AUTHOR|(CDS)2067108; Biancacci, Nicolo; Bracco, Chiara; Frasciello, Oscar; Gentini, Luca; Goddard, Brennan; Lechner, Anton; Maciariello, Fausto; Perillo Marcone, Antonio; Salvant, Benoit; Shetty, Nikhil Vittal; Steele, Genevieve; Velotti, Francesco; Zobov, Mikhail

2015-01-01

The injector complex of the LHC is undergoing important changes in the light of the LIU project to provide brighter beams to the LHC. For this reason and as part of the High Luminosity LHC project the injection protection system of the LHC will be upgraded in the Long Shutdown 2 (2018 - 2019) to be able to protect downstream elements against injection failures with the high brightness, high intensity HL-LHC beams. The upgraded LHC injection protection system will consist of a segmented injection protection absorber TDIS, and auxiliary collimators and masks. The layout modifications are described, and the machine element protection and absorber jaw robustness studies are presented for the new systems.

Clinicopathologic consensus study of gray zone lymphoma with features intermediate between DLBCL and classical HL.

Science.gov (United States)

Pilichowska, Monika; Pittaluga, Stefania; Ferry, Judith A; Hemminger, Jessica; Chang, Hong; Kanakry, Jennifer A; Sehn, Laurie H; Feldman, Tatyana; Abramson, Jeremy S; Kritharis, Athena; Hernandez-Ilizaliturri, Francisco J; Lossos, Izidore S; Press, Oliver W; Fenske, Timothy S; Friedberg, Jonathan W; Vose, Julie M; Blum, Kristie A; Jagadeesh, Deepa; Woda, Bruce; Gupta, Gaurav K; Gascoyne, Randy D; Jaffe, Elaine S; Evens, Andrew M

2017-12-12

Gray zone lymphoma (GZL) is described as sharing features with classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL). However, there remains complexity in establishing diagnosis, delineating prognosis, and determining optimum therapy. Sixty-eight cases diagnosed as GZL across 15 North American academic centers were evaluated by central pathology review to achieve consensus. Of these, only 26 (38%) were confirmed as GZL. Morphology was critical to GZL consensus diagnosis (eg, tumor cell richness); immunohistochemistry showed universal B-cell derivation, frequent CD30 expression, and rare Epstein-Barr virus (EBV) positivity (CD20 + , 83%; PAX5 + , 100%; BCL6 + , 20%; MUM1 + , 100%; CD30 + , 92%; EBV + , 4%). Forty-two cases were reclassified: nodular sclerosis (NS) cHL, n = 27 (including n = 10 NS grade 2); lymphocyte predominant HL, n = 4; DLBCL, n = 4; EBV + DLBCL, n = 3; primary mediastinal large BCL n = 2; lymphocyte-rich cHL and BCL-not otherwise specified, n = 1 each. GZL consensus-confirmed vs reclassified cases, respectively, more often had mediastinal disease (69% vs 41%; P = .038) and less likely more than 1 extranodal site (0% vs 25%; P = .019). With a 44-month median follow-up, 3-year progression-free survival (PFS) and overall survival for patients with confirmed GZL were 39% and 95%, respectively, vs 58% and 85%, respectively, for reclassified cases ( P = .19 and P = .15, respectively). Interestingly, NS grade 2 reclassified patients had similar PFS as GZL consensus-confirmed cases. For prognostication of GZL cases, hypoalbuminemia was a negative factor (3-year PFS, 12% vs 64%; P = .01), whereas frontline cyclophosphamide, doxorubicin, vincristine, and prednisone ± rituximab (CHOP±R) was associated with improved 3-year PFS (70% vs 20%; P = .03); both factors remained significant on multivariate analysis. Altogether, accurate diagnosis of GZL remains challenging, and improved therapeutic strategies are needed.

OHD/HL - XEFS

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System (EVS) Graphics Generator (GraphGen) [Video Training, NOAA login (email minus @noaa.gov) required ] Download Latest Versions of XEFS Components [NOAA login required, except for EVS downloads] new icon . Graphics Generator (GraphGen) [Video Training, NOAA login (email minus @noaa.gov) required] The Graphics

q-Poincaré supersymmetry in AdS5/CFT4

Science.gov (United States)

Borsato, Riccardo; Torrielli, Alessandro

2018-03-01

We consider the exact S-matrix governing the planar spectral problem for strings on AdS5 ×S5 and N = 4 super Yang-Mills, and we show that it is invariant under a novel "boost" symmetry, which acts as a differentiation with respect to the particle momentum. This generator leads us also to reinterpret the usual centrally extended psu (2 | 2) symmetry, and to conclude that the S-matrix is invariant under a q-Poincaré supersymmetry algebra, where the deformation parameter is related to the 't Hooft coupling. We determine the two-particle action (coproduct) that turns out to be non-local, and study the property of the new symmetry under crossing transformations. We look at both the strong-coupling (large tension in the string theory) and weak-coupling (spin-chain description of the gauge theory) limits; in the former regime we calculate the cobracket utilising the universal classical r-matrix of Beisert and Spill. In the eventuality that the boost has higher partners, we also construct a quantum affine version of 2D Poincaré symmetry, by contraction of the quantum affine algebra Uq (sl2 ˆ) in Drinfeld's second realisation.

q-Poincaré supersymmetry in AdS5/CFT4

Directory of Open Access Journals (Sweden)

Riccardo Borsato

2018-03-01

Full Text Available We consider the exact S-matrix governing the planar spectral problem for strings on AdS5×S5 and N=4 super Yang–Mills, and we show that it is invariant under a novel “boost” symmetry, which acts as a differentiation with respect to the particle momentum. This generator leads us also to reinterpret the usual centrally extended psu(2|2 symmetry, and to conclude that the S-matrix is invariant under a q-Poincaré supersymmetry algebra, where the deformation parameter is related to the 't Hooft coupling. We determine the two-particle action (coproduct that turns out to be non-local, and study the property of the new symmetry under crossing transformations. We look at both the strong-coupling (large tension in the string theory and weak-coupling (spin-chain description of the gauge theory limits; in the former regime we calculate the cobracket utilising the universal classical r-matrix of Beisert and Spill. In the eventuality that the boost has higher partners, we also construct a quantum affine version of 2D Poincaré symmetry, by contraction of the quantum affine algebra Uq(sl2ˆ in Drinfeld's second realisation.

Offline Reconstruction Algorithms for the CMS High Granularity Calorimeter for HL-LHC

CERN Document Server

Chen, Z; Meschi, Emilio; Scott, Edward John Titman; Seez, Christopher

2017-01-01

The upgraded High Luminosity LHC, after the third Long Shutdown (LS3), will provide an instantaneous luminosity of $7.5 \\times 10^{34}$ cm$^{-2}$ s$^{-1}$ (levelled), at theCollaboration price of extreme pileup of up to 200 interactions per crossing. Such extreme pileup poses significant challenges, in particular for forward calorimetry. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic and hadronic compartments. The electromagnetic and a large fraction of the hadronic portions will be based on hexagonal silicon sensors of 0.5 - 1 cm$^2$ cell size, with the remainder of the hadronic portion based on highly-segmented scintillators with SiPM readout. Offline clustering algorithms that make use of this extreme granularity require novel approaches to preserve the fine structure of showers and to be stable against pileup, wh...

Effects of 7 days on an ad libitum low-fat vegan diet: the McDougall Program cohort.

Science.gov (United States)

McDougall, John; Thomas, Laurie E; McDougall, Craig; Moloney, Gavin; Saul, Bradley; Finnell, John S; Richardson, Kelly; Petersen, Katelin Mae

2014-10-14

Epidemiologic evidence, reinforced by clinical and laboratory studies, shows that the rich Western diet is the major underlying cause of death and disability (e.g, from cardiovascular disease and type 2 diabetes) in Western industrialized societies. The objective of this study is to document the effects that eating a low-fat (≤10% of calories), high-carbohydrate (~80% of calories), moderate-sodium, purely plant-based diet ad libitum for 7 days can have on the biomarkers of cardiovascular disease and type 2 diabetes. Retrospective analysis of measurements of weight, blood pressure, blood sugar, and blood lipids and estimation of cardiovascular disease risk at baseline and day 7 from 1615 participants in a 10-day residential dietary intervention program from 2002 to 2011. Wilcoxon's signed-rank test was used for testing the significance of changes from baseline. The median (interquartile range, IQR) weight loss was 1.4 (1.8) kg (p 7.5% at baseline, the risk dropped to 5.5% (>27%) at day 7 (p vegan diet eaten ad libitum for 7 days results in significant favorable changes in commonly tested biomarkers that are used to predict future risks for cardiovascular disease and metabolic diseases.

Fast reciprocating probe system on the HL-2A tokamak

International Nuclear Information System (INIS)

Yan Longwen; Hong Wenyu; Qian Jun; Luo Cuiwen; Pan Li

2005-01-01

A reciprocating probe system has been installed at the midplane of the HL-2A tokamak. The probe is used to measure plasma edge density, temperature, floating potential, and corresponding fluctuation profiles with 8 cm scan from the scrape-off layer to the plasma boundary. The reciprocating probe can move at a speed of 1 m/s. A digital grating displacement measurement system that can provide a high displacement resolution of 0.04 mm is applied to the reciprocating probe system for the first time. A port located behind the vacuum isolation valve is designed for viewing and the exchange of the probe head. Different probe heads can be used to satisfy different experimental requirements. The first probe head had four graphite measurement tips. For high frequency response, no isolation amplifier is used in the electric circuit of the probe measurement. A personal computer via an analog-to-digital digitizer card acquires probe system data, which are sent to a data server by optical fiber after a discharge. All data are sent to the centralized data management system of the HL-2A. In this article we presented the edge temperature and density profiles for the limiter and divertor configurations of a selected plasma discharge

HUNTING FOR PLANETS IN THE HL TAU DISK

Energy Technology Data Exchange (ETDEWEB)

Testi, L. [ESO, Karl Schwarzschild str. 2, D-85748 Garching bei Muenchen (Germany); Skemer, A.; Bailey, V.; Defrère, D.; Hinz, Ph.; Leisenring, J.; Vaz, A. [Steward Observatory, University of Arizona, 933 N. Cherry Ave., Tucson, AZ 85721 (United States); Henning, Th. [Max Planck Institute for Astronomie, Königstuhl 17, D-69117 Heidelberg (Germany); Esposito, S. [INAF-Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy); Fontana, A. [INAF-Osservatorio Astronomico di Roma, Monte Porzio (Italy); Marconi, A. [Universitá degli Studi di Firenze, Dipartimento di Fisica e Astronomia, Firenze (Italy); Skrutskie, M. [University of Virginia, 530 McCormick Road, Charlottesville, VA 22904 (United States); Veillet, C., E-mail: ltesti@eso.org [LBT Observatory, University of Arizona, 933 N. Cherry Ave., Tucson, AZ 85721 (United States)

2015-10-20

Recent ALMA images of HL Tau show gaps in the dusty disk that may be caused by planetary bodies. Given the young age of this system, if confirmed, this finding would imply very short timescales for planet formation, probably in a gravitationally unstable disk. To test this scenario, we searched for young planets by means of direct imaging in the L′ band using the Large Binocular Telescope Interferometer mid-infrared camera. At the location of two prominent dips in the dust distribution at ∼70 AU (∼0.″5) from the central star, we reach a contrast level of ∼7.5 mag. We did not detect any point sources at the location of the rings. Using evolutionary models we derive upper limits of ∼10–15 M{sub Jup} at ≤0.5–1 Ma for the possible planets. With these sensitivity limits we should have been able to detect companions sufficiently massive to open full gaps in the disk. The structures detected at millimeter wavelengths could be gaps in the distributions of large grains on the disk midplane caused by planets not massive enough to fully open the gaps. Future ALMA observations of the molecular gas density profile and kinematics as well as higher contrast infrared observations may be able to provide a definitive answer.

HUNTING FOR PLANETS IN THE HL TAU DISK

International Nuclear Information System (INIS)

Testi, L.; Skemer, A.; Bailey, V.; Defrère, D.; Hinz, Ph.; Leisenring, J.; Vaz, A.; Henning, Th.; Esposito, S.; Fontana, A.; Marconi, A.; Skrutskie, M.; Veillet, C.

2015-01-01

Recent ALMA images of HL Tau show gaps in the dusty disk that may be caused by planetary bodies. Given the young age of this system, if confirmed, this finding would imply very short timescales for planet formation, probably in a gravitationally unstable disk. To test this scenario, we searched for young planets by means of direct imaging in the L′ band using the Large Binocular Telescope Interferometer mid-infrared camera. At the location of two prominent dips in the dust distribution at ∼70 AU (∼0.″5) from the central star, we reach a contrast level of ∼7.5 mag. We did not detect any point sources at the location of the rings. Using evolutionary models we derive upper limits of ∼10–15 M Jup at ≤0.5–1 Ma for the possible planets. With these sensitivity limits we should have been able to detect companions sufficiently massive to open full gaps in the disk. The structures detected at millimeter wavelengths could be gaps in the distributions of large grains on the disk midplane caused by planets not massive enough to fully open the gaps. Future ALMA observations of the molecular gas density profile and kinematics as well as higher contrast infrared observations may be able to provide a definitive answer

Validation of the Spanish version of the Baylor Profound Mental Status Examination.

Science.gov (United States)

Salmerón, Sergio; Huedo, Isabel; López-Utiel, Melisa; Soler-Moratalla, Isabel; Flores-Ruano, Teresa; Fernández-Sánchez, Miguel; Noguerón, Alicia; Doody, Rachelle S; Abizanda, Pedro

2016-01-01

There are no short valid instruments to evaluate cognitive status in severe Alzheimer's disease (AD) patients in the Spanish language. To validate the Spanish version of the Baylor Profound Mental Status Examination (BPMSE-Sp). The Baylor Profound Mental Status Examination (BPMSE) was translated to Spanish and back translated. Validation was conducted in 100 patients with severe probable AD with a Mini-Mental State Examination (MMSE) reliability. The mean age of patients was 84.9; 74% were female; 64% were institutionalized. The mean MMSE was 5.6; the mean BPMSE-Sp was 13.6; the mean BPMSE-Sp behavior was 1.2; the mean SIB was 42.2; and the mean NPI-Q was 4.7. BPMSE-Sp presented good internal consistency (Cronbach α= 0.84). There were significant correlations between the BPMSE-Sp and MMSE (r = 0.86, p reliability were in both cases excellent, ranging between 0.96 and 0.99 (p <  0.001). BPMSE-Sp had fewer floor and ceiling effects than the MMSE. The BPMSE-Sp is a valid tool for use in daily practice and research in the evaluation of cognitive function of patients with severe AD.

Effect of recycling in the HL-1M tokamak

International Nuclear Information System (INIS)

Zheng Yongzhen

2004-01-01

Tokamak plasma discharge disruption at high density is investigated. The instability analysis on model indicates that the disruption is resulted from the energy loss arising from hydrogen recycling on the edge of the plasma. This energy loss could lead to a contraction of the current channel and the production of a disruptively unstable configuration. Using a simple model we shall investigate the implications of recycling for disruptions. The critical high-density n≤1.6 x 10 20 m -3 is reached in HL-1M. (author)

Simplifying superstring and D-brane actions in AdS4 x CP3 superbackground

International Nuclear Information System (INIS)

Grassi, Pietro Antonio; Sorokin, Dmitri; Wulff, Linus

2009-01-01

By making an appropriate choice for gauge fixing kappa-symmetry we obtain a relatively simple form of the actions for a D = 11 superparticle in AdS 4 x S 7 /Z k , and for a D0-brane, fundamental string and D2-branes in the AdS 4 x CP 3 superbackground. They can be used to study various problems of string theory and the AdS 4 /CFT 3 correspondence, especially in regions of the theory which are not reachable by the OSp(6|4)/U(3) x SO(1,3) supercoset sigma-model. In particular, we present a simple form of the gauge-fixed superstring action in AdS 4 x CP 3 and briefly discuss issues of its T-dualization.

The ATLAS liquid argon calorimeter: upgrade plans for the HL-LHC

CERN Document Server

Novgorodova, O; The ATLAS collaboration

2014-01-01

The ATLAS detector was designed and built to study proton-proton collisions produced at the LHC at centre-of-mass energies up to 14 TeV and instantaneous luminosities up to 1034cm-2s-1. Liquid argon (LAr) sampling calorimeters are employed for all electromagnetic calorimetry in the pseudorapidity region |η|<3.2, and for hadronic calorimetry in the region from |η|=1.5 to |η|=4.9. Although the nominal LHC experimental programme is still in progress, plans for a High Luminosity LHC (HL-LHC) are already being developed for operation of the collider and associated detectors at luminosities of up to (5-7)×1034 cm-2s-1, with the goal of accumulating an integrated luminosity of 3000 fb-1. The proposed instantaneous and integrated luminosities are both well beyond the values for which the detectors were designed. The electromagnetic and hadronic calorimeters will be able to tolerate the increased particle flux, but the performance of the forward calorimeter (FCal) will be affected. Two solutions for this are un...

[Expression of ICAT and Wnt signaling-related proteins in the monocytic differentiation of HL-60 cells induced by a new steroidal drug NSC67657].

Science.gov (United States)

Wang, J S; Wang, W J; Wang, T; Zhang, Y

2016-04-01

To investigate the expression of mRNA and proteins of β-catenin, TCF-4 (ICAT) and Wnt signaling pathway-related genes in the monocytic differentiation of acute myeloid leukemia HL-60 cells induced by a new steroidal drug NSC67657. Wright's staining and α-NBE staining were used to observe the differentiation of HL-60 cells after 5 days of 10 μmol/L NSC67657 treatment. Flow cytometry (FCM) was used to detect the differentiation and cell cycles. The expressions of mRNA and proteins of ICAT and Wnt signaling pathway-related factors, including β-catenin, TCF-4, c-myc, cyclin D1 and TCF-1 before and after differentiation, were detected by RT-PCR and Western blot. Morphological observation showed that NSC67657 induced monocytic differentiation of HL-60 cells. At 5 days after 10 μmol/L NSC67657 treatment, the number of CD14(+) HL-60 cells was (94.37±2.84)%, significantly higher than the (1.31±0.09)% in control group (Pcells were of (18.76±0.98)%, significantly lower than that of (34.38±2.61) % in the control group (Pprotein, and down-regulated the expression of β-catenin mRNA and protin (Pprotein and nuclear protein in the HL-60 cells (P>0.05 for all). The target genes of Wnt signaling pathway, including c-myc, cyclinD1 and TCF-1 mRNA and proteins in the HL-60 cells were significantly down-regulated after NSC67657 treatment (Pcells, and down-regulates the expression of β-catenin and target genes of Wnt signaling pathway. These results indicate that Wnt signaling pathway may be directly or indirectly involved in the monocytic differentiation process of HL-60 cells.

Non-equilibrium scalar two point functions in AdS/CFT

Energy Technology Data Exchange (ETDEWEB)

Keränen, Ville [Rudolf Peierls Centre for Theoretical Physics, University of Oxford,1 Keble Road, Oxford OX1 3NP (United Kingdom); Kleinert, Philipp [Rudolf Peierls Centre for Theoretical Physics, University of Oxford,1 Keble Road, Oxford OX1 3NP (United Kingdom); Merton College, University of Oxford,Merton Street, Oxford OX1 4JD (United Kingdom)

2015-04-22

In the first part of the paper, we discuss different versions of the AdS/CFT dictionary out of equilibrium. We show that the Skenderis-van Rees prescription and the “extrapolate” dictionary are equivalent at the level of “in-in” two point functions of free scalar fields in arbitrary asymptotically AdS spacetimes. In the second part of the paper, we calculate two point correlation functions in dynamical spacetimes using the “extrapolate” dictionary. These calculations are performed for conformally coupled scalar fields in examples of spacetimes undergoing gravitational collapse, the AdS{sub 2}-Vaidya spacetime and the AdS{sub 3}-Vaidya spacetime, which allow us to address the problem of thermalization following a quench in the boundary field theory. The computation of the correlators is formulated as an initial value problem in the bulk spacetime. Finally, we compare our results for AdS{sub 3}-Vaidya to results in the previous literature obtained using the geodesic approximation and we find qualitative agreement.

Collimator Layouts for HL-LHC in the Experimental Insertions

CERN Document Server

Bruce, R; Esposito, Luigi Salvatore; Jowett, John; Lechner, Anton; Quaranta, Elena; Redaelli, Stefano; Schaumann, Michaela; Skordis, Eleftherios; Eleanor Steele, G; Garcia Morales, H; Kwee-Hinzmann, Regina

2015-01-01

This paper presents the layout of collimators for HL-LHC in the experimental insertions. On the incoming beam, we propose to install additional tertiary collimators to protect potential new aperture bottlenecks in cells 4 and 5, which in addition reduce the experimental background. For the outgoing beam, the layout of the present LHC with three physics debris absorbers gives sufficient protection for highluminosity proton operation. However, collisional processes for heavy ions cause localized beam losses with the potential to quench magnets. To alleviate these losses, an installation of dispersion suppressor collimators is proposed.

Upgrade Plans for ATLAS Forward Calorimetry for the HL-LHC

Science.gov (United States)

Turner, J.; ATLAS Liquid Argon Calorimeter Group

Even though the LHC is still in an early phase of operation, plans are being developed to operate the machine and its detectors at up to 10 times the original design luminosity. This has a major impact on the Forward Calorimeter (FCal), which is exposed to some of the highest radiation rates in ATLAS. The FCal detector and its associated components were designed for operation at the maximum LHC luminosity of 1034 cm-2s-1. However at the higher luminosities projected for the HL-LHC, operation of the FCal may be compromised. Beam heating in the FCal could lead to the formation of argon bubbles in the detector, the ionization rate will result in space charge effects that will reduce the signal and the current draw will result in a voltage drop across the HV current limiting resistors. Two possible solutions are being considered to maintain FCal operation at HL-LHC. One is a complete replacement of the FCal system. A replacement FCal would have a similar design to the current calorimeter except for the addition of cooling loops, lower value HV protection resistors and the use of smaller ionization gaps, as small as 100 microns in the first compartment. The second solution is the installation of a small warm calorimeter, referred to as the Mini-FCal, to be placed in front of the FCal. This addition would reduce the ionization load in the first FCal compartment, which would keep a larger region of the FCal active and reduce the heat load to an acceptable level. The current concept for the Mini-FCal is a standard parallel plate calorimeter with copper absorbers and diamond sensors, which were chosen for their inherent radiation resistance. It is anticipated that neutrons will be the major cause of damage to the diamond sensors and the integrated flux of neutrons in the Mini-FCal after 3000 fb-1 at the HL-LHC will be up to 2 x 1017 neutrons/cm2. Recent irradiation tests carried out by members of the ATLAS Liquid Argon group show that these sensors can still operate after

Financial and health literacy predict incident AD dementia and AD pathology

Science.gov (United States)

Yu, Lei; Wilson, Robert S.; Schneider, Julie A.; Bennett, David A.; Boyle, Patricia A.

2017-01-01

Background Domain specific literacy is a multidimensional construct that requires multiple resources including cognitive and non-cognitive factors. Objective We test the hypothesis that domain specific literacy is associated with AD dementia and AD pathology after controlling for cognition. Methods Participants were community based older persons who completed a baseline literacy assessment, underwent annual clinical evaluations for up to 8 years and agreed to organ donation after death. Financial and health literacy was measured using 32 questions and cognition was measured using 19 tests. Annual diagnosis of AD dementia followed standard criteria. AD pathology was examined post-mortem by quantifying plaques and tangles. Cox models examined the association of literacy with incident AD dementia. Performance of model prediction for incident AD dementia was assessed using indices for integrated discrimination improvement and continuous net reclassification improvement. Linear regression models examined the independent association of literacy with AD pathology in autopsied participants. Results All 805 participants were free of dementia at baseline and 102 (12.7%) developed AD dementia during the follow-up. Lower literacy was associated with higher risk for incident AD dementia (pliteracy measure had better predictive performance than the one with demographics and cognition only. Lower literacy also was associated with higher burden of AD pathology after controlling for cognition (β=0.07, p=0.035). Conclusion Literacy predicts incident AD dementia and AD pathology in community-dwelling older persons, and the association is independent of traditional measures of cognition. PMID:28157101

AdS-phobia, the WGC, the Standard Model and Supersymmetry

Science.gov (United States)

Gonzalo, Eduardo; Herráez, Alvaro; Ibáñez, Luis E.

2018-06-01

It has been recently argued that an embedding of the SM into a consistent theory of quantum gravity may imply important constraints on the mass of the lightest neutrino and the cosmological constant Λ4. The constraints come from imposing the absence of any non-SUSY AdS stable vacua obtained from any consistent compactification of the SM to 3 or 2 dimensions. This condition comes as a corollary of a recent extension of the Weak Gravity Conjecture (WGC) by Ooguri and Vafa. In this paper we study T 2 /Z N compactifications of the SM to two dimensions in which SM Wilson lines are projected out, leading to a considerable simplification. We analyze in detail a T 2 /Z 4 compactification of the SM in which both complex structure and Wilson line scalars are fixed and the potential is only a function of the area of the torus a 2. We find that the SM is not robust against the appearance of AdS vacua in 2D and hence would be by itself inconsistent with quantum gravity. On the contrary, if the SM is embedded at some scale M SS into a SUSY version like the MSSM, the AdS vacua present in the non-SUSY case disappear or become unstable. This means that WGC arguments favor a SUSY version of the SM, independently of the usual hierarchy problem arguments. In a T 2 /Z 4 compactification in which the orbifold action is embedded into the B - L symmetry the bounds on neutrino masses and the cosmological constant are recovered. This suggests that the MSSM should be extended with a U(1) B- L gauge group. In other families of vacua the spectrum of SUSY particles is further constrained in order to avoid the appearance of new AdS vacua or instabilities. We discuss a possible understanding of the little hierarchy problem in this context.

Predictive study on high performance modes of operation in HL-2A

International Nuclear Information System (INIS)

Gao Qingdi; Li Fangzhu; Zhang Jinhua; Qu Hongpeng; Budny, R.V.

2003-01-01

High performance scenarios in the HL-2A tokamak are studied by numerical modeling. Through shifting the plasma column outwards a shaping plasma with significant triangularity is achieved with sufficient room left for the RF antenna. For the out-shifted shaping plasma, ripple loss of high energy ions during NBI is analyzed. The results show that the ripple loss fraction of NBI power for the shaping plasma is not higher than that for the unshifted circular plasma. The time dependent TRANSP code is used to model realistic reversed magnetic shear operation in HL-2A. In order to sustain the RS operation towards steady-state, off-axis current drive with a lower hybrid wave at 2.45GHz is used to control the current profile. A steady-state RS discharge is formed and sustained until the LH power is turned off; the plasma confinement is enhanced with the development of an internal transport barrier. In the RS discharges with shaping plasma geometry a double transport barrier is produced. (author)

Observation of electron temperature profile in HL-1M tokamak

International Nuclear Information System (INIS)

Cao Jianyong; Xu Deming; Ding Xuantong

2000-01-01

The principle and method of the electron temperature measurement by means of electron cyclotron emission (ECE) have been described. Several results under different conditions on HL-1M tokamak have been given. The hollow profile of electron temperature appears in some stages, such as current rising, pellet injection and impurity concentration in the plasma centre. When the bias voltage is applied, the electron temperature profile become steeper. All of the phenomena are related with the transport in plasma centre

A quantum check of AdS/dCFT

DEFF Research Database (Denmark)

Buhl-Mortensen, Isak; de Leeuw, Marius; Ipsen, Asger C.

2017-01-01

-time dependence of the theory’s Minkowski space propagators is handled by reformulating these as propagators in an effective AdS4. Subsequently, we initiate the computation of quantum corrections. The one-loop correction to the one-point function of any local gauge-invariant scalar operator is shown to receive......We build the framework for performing loop computations in the defect version of N = 4 super Yang-Mills theory which is dual to the probe D5-D3 brane system with background gauge-field flux. In this dCFT, a codimension-one defect separates two regions of space-time with different ranks of the gauge...

Validation of the Spanish-language version of the Relevant Outcome Scale for Alzheimer's Disease.

Science.gov (United States)

Carnero Pardo, C; López Alcalde, S; Espinosa García, M; Sánchez Magro, I

2017-09-01

The Relevant Outcome Scale for Alzheimer's Disease (ROSA) is a useful tool for evaluating and monitoring dementia patients. This study aims to evaluate the validity and reliability of the Spanish version of ROSA. Spanish multicentre study involving 39 researchers and including 237 patients with Alzheimer disease (78 mild, 79 moderate, and 80 severe). The patients were tested with the following: Mini-Mental State Examination (MMSE), Fototest, Neuropsychiatric Inventory (NPI), Blessed dementia scale, and a Spanish-language version of ROSA. A subsample of 40 subjects was retested in the 14 days following the initial evaluation. The construct validity was evaluated with the Spearman correlation coefficient (r), internal consistency with Cronbach's alpha (alpha), and test-retest reliability with the intraclass correlation coefficient (ICC). ROSA requires 13.8±7.4minutes to administer and its results show a significant association with the clinical stage of AD (mild, 116.7±23.1; moderate, 92.9±19.8; and severe, 64.3±22.6), and with results on the MMSE (r=0.68), Fototest (r=0.63), NPI (r=0.53), and Blessed dementia scale (r=-0.80). ROSA shows high internal consistency (alpha=0.90) and excellent test-retest reliability (ICC0.97). The Spanish version of ROSA is a brief, valid, and reliable tool permitting overall evaluation of patients with dementia. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

A High-Granularity Timing Detector (HGTD) in ATLAS : Performance at the HL-LHC

CERN Document Server

Allaire, Corentin; The ATLAS collaboration

2018-01-01

The large increase of pileup is one of the main experimental challenges for the HL-LHC physics program. A powerful new way to address this challenge is to exploit the time spread of the interactions to distinguish between collisions occurring very close in space but well separated in time. A High-Granularity Timing Detector, based on low gain avalanche detector technology, is proposed for the ATLAS Phase-II upgrade. Covering the pseudorapidity region between 2.4 and 4.0, with a timing resolution of 30 ps for minimum-ionizing particles, this device will significantly improve the performance in the forward region. High-precision timing greatly improves the track-to-vertex associ- ation, leading to a performance similar to that in the central region for both jet and lepton reconstruction, as well as the tagging of heavy-flavour jets. These improvements in object reconstruction performance translate into impor- tant sensitivity gains and enhance the reach of the HL-LHC physics program. In addition, the HGTD offer...

Amino acid sequences of the ribosomal proteins HL30 and HmaL5 from the archaebacterium Halobacterium marismortui.

Science.gov (United States)

Hatakeyama, T; Hatakeyama, T

1990-07-06

The complete amino acid sequences of the ribosomal proteins HL30 and HmaL5 from the archaebacterium Halobacterium marismortui were determined. Protein HL30 was found to be acetylated at its N-terminal amino acid and shows homology to the eukaryotic ribosomal proteins YL34 from yeast and RL31 from rat. Protein HmaL5 was homologous to the protein L5 from Escherichia coli and Bacillus stearothermophilus as well as to YL16 from yeast. HmaL5 shows more similarities to its eukaryotic counterpart than to eubacterial ones.

Membranes from monopole operators in ABJM theory: Large angular momentum and M-theoretic AdS4/CFT3

International Nuclear Information System (INIS)

Kovacs, Stefano; Sato, Yuki; Shimada, Hidehiko

2014-01-01

We study the duality between M-theory in AdS 4 ×S 7 /ℤ k and the ABJM N=6 Chern–Simons-matter theory with gauge group U(N)×U(N) and level k, taking N large and k of order 1. In this M-theoretic regime the lack of an explicit formulation of M-theory in AdS 4 ×S 7 /ℤ k makes the gravity side difficult, while the CFT is strongly coupled and the planar approximation is not applicable. We focus on states on the gravity side with large angular momentum J≫1 associated with a single plane of rotation in S 7 and identify their dual operators in the CFT. We show that natural approximation schemes arise on both sides thanks to the presence of the small parameter 1/J. On the AdS side, we use the matrix model of M-theory on the maximally supersymmetric pp-wave background with matrices of size J/k. A perturbative treatment of this matrix model provides a good approximation to M-theory in AdS 4 ×S 7 /ℤ k when N 1/3 ≪J≪N 1/2 . On the CFT side, we study the theory on S 2 ×ℝ with magnetic flux J/k. A Born–Oppenheimer-type expansion arises naturally for large J in spite of the theory being strongly coupled. The energy spectra on the two sides agree at leading order. This provides a non-trivial test of the AdS 4 /CFT 3 correspondence including near-BPS observables associated with membrane degrees of freedom, thus verifying the duality beyond the previously studied sectors corresponding to either BPS observables or the type IIA string regime

Supersymmetric AdS3, AdS2 and bubble solutions

International Nuclear Information System (INIS)

Gauntlett, Jerome P.; Waldram, Daniel; Kim, Nakwoo

2007-01-01

We present new supersymmetric AdS 3 solutions of type IIB supergravity and AdS 2 solutions of D = 11 supergravity. The former are dual to conformal field theories in two dimensions with N = (0, 2) supersymmetry while the latter are dual to conformal quantum mechanics with two supercharges. Our construction also includes AdS 2 solutions of D = 11 supergravity that have non-compact internal spaces which are dual to three-dimensional N = 2 superconformal field theories coupled to point-like defects. We also present some new bubble-type solutions, corresponding to BPS states in conformal theories, that preserve four supersymmetries

Numerical simulation of MHD equilibrium configuration for the HL-2A modification

International Nuclear Information System (INIS)

Chen Qian; Wang Aike; Li Fangzhu; Zhang Jinghua

2008-01-01

Numerical simulation is employed for the HL-2A modification, which includes the optimum design of zero-field in the start-up phase, the limiter equilibrium configuration, the single/double null divertor equilibrium configuration, and the equilibrium configuration evolution from gas breakdown to current plateau. Results show that the new program can satisfy the design requirement. (authors)

ADAMS/WT advanced development - version 1.4 and beyond

Energy Technology Data Exchange (ETDEWEB)

Elliott, A.S.; Depauw, T.R. [Mechanical Dynamics, Inc., Mesa, AZ (United States)

1996-12-31

ADAMS/WT is an wind-turbine-specific shell for the general-purpose mechanical system simulation package ADAMS5. It was developed under the guidance of the National Renewable Energy Laboratory to give engineers and analysts in the wind turbine community access to the analytical power of ADAMS, without having to become expert in its particular technology. The 1.4 version of ADAMS/WT is the most recent upgrade to the package, incorporating the most up-to-date version of the AeroDyn aerodynamic forcing subroutines from the University of Utah. It is also the first version to be made available on the Windows/NT platform. In version 1.4, ADAMS/WT has been significantly improved throughout and runs much faster. Automatic generation of standardized output has been added. The documentation has been extensively augmented with more detailed descriptions, more figures and more examples. ADAMS/WT remains the most powerful analytical tool available for horizontal-axis wind turbine development. 10 figs.

Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells.

Science.gov (United States)

Kawaii, Satoru; Lansky, Ephraim P

2004-01-01

Differentiation refers to the ability of cancer cells to revert to their normal counterparts, and its induction represents an important noncytotoxic therapy for leukemia, and also breast, prostate, and other solid malignancies. Flavonoids are a group of differentiation-inducing chemicals with a potentially lower toxicology profile than retinoids. Flavonoid-rich polyphenol fractions from the pomegranate (Punica granatum) fruit exert anti-proliferative, anti-invasive, anti-eicosanoid, and pro-apoptotic actions in breast and prostate cancer cells and anti-angiogenic activities in vitro and in vivo. Here we tested flavonoid-rich fractions from fresh (J) and fermented (W) pomegranate juice and from an aqueous extraction of pomegranate pericarps (P) as potential differentiation-promoting agents of human HL-60 promyelocytic leukemia cells. Four assays were used to assess differentiation: nitro blue tetrazolium reducing activity, nonspecific esterase activity, specific esterase activity, and phagocytic activity. In addition, the effect of these extracts on HL-60 proliferation was evaluated. Extracts W and P were strong promoters of differentiation in all settings, with extract J showing only a relatively mild differentiation-promoting effect. The extracts had proportional inhibitory effects on HL-60 cell proliferation. The results highlight an important, previously unknown, mechanism of the cancer preventive and suppressive potential of pomegranate fermented juice and pericarp extracts.

Application of the Chinese Version of the Whiteley Index-7 for Detecting DSM-5 Somatic Symptom and Related Disorders.

Science.gov (United States)

Tu, Chao-Ying; Liao, Shih-Cheng; Liu, Chao-Yu; Chen, Tzu-Ting; Chen, I-Ming; Lin, Kuan-Fu; Huang, Wei-Lieh

2016-01-01

The Whiteley Index-7 (WI-7) is frequently used for evaluating patients with suspected hypochondriasis. However, information about its use on somatic symptom and related disorders in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) is still lacking. This study investigated the psychometric properties of the Mandarin Chinese version of the WI-7 and its application to evaluation of somatic symptom and related disorders. Participants completed the WI-7 and received diagnostic interview based on both Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and DSM-5 criteria. Exploratory factor analysis was performed, and the test-retest reliability and the internal consistency of the WI-7 were assessed. Receiver Operating Characteristic curves were established, and the area under the curve was calculated to determine the cutoff point to distinguish DSM-IV somatoform disorders and DSM-5 somatic symptom and related disorders, respectively. A total of 471 subjects were recruited for this study. The exploratory factor analysis of the WI-7 identified a single factor. The internal consistency and test-retest reliability of the WI-7 were 0.829 and 0.836, respectively. The area under Receiver Operating Characteristic curve using WI-7 to distinguish DSM-5 somatic symptom and related disorders is 0.660, higher than that when applying to distinguish DSM-IV somatoform disorders. The sensitivity and specificity at an optimal cutoff point of 0/1 are 0.645 and 0.675, respectively. The Mandarin Chinese version of the WI-7 is a potentially useful tool to detect individuals with DSM-5 somatic symptom and related disorders. Copyright © 2016 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.

A comparative study of 99mTc-HL91 and 99mTc-MIBI imaging in experimental tumor and inflammatory models

International Nuclear Information System (INIS)

Cao, W.; Zhang, X.Y.; An, R.

2002-01-01

Aim: 99m Tc-HL91 is a newly developed hypoxic imaging agent for ischemic myocardium and tumor imaging. 99m Tc-MIBI is one of imaging agent for mammary tumor imaging. The aim of this experiment is to evaluate the diagnostic value of 99m Tc-HL91 in detection of solid tumor in experimental tumor and inflammatory models, via comparative study with 99m Tc-MIBI. Material and Methods: HL91 kits was provided by China Nine Star Co. Three kinds of bearing solid neoplasm mice groups (bearing Ehrlich carcinoma mice, bearing H 22 carcinoma mice and bearing human ovarian COC 1 neoplasm nude mice) and two inflammatory model groups (chemical and bacterial inflammation) underwent static whole body planar images at 1 and 4 hours post injection of 99m Tc-HL91. Two kinds of bearing neoplasm mice groups (bearing Ehrlich carcinoma mice, bearing H 22 carcinoma mice) and two inflammatory model groups (chemical and bacterial inflammation) underwent static planar images post injection of 99m Tc-MIBI, at early phase (10∼20 minutes) and delayed phase (2 hrs). All of mice were sacrificed at 4 hrs. The tumors, or inflammatory lesions, blood and contralateral muscles were removed, weighed and the radioactivity was measured. Regions of interesting (ROIs) were drawn around tumor, inflammatory lesions and contralateral muscles in planar images, and the radioactivity ratios of target (tumor or inflammatory lesions)-to-blood (T/B), target-to-non target (contralateral muscles) i. e. T/NT was calculated. Results: Neoplasm can be clearly visible in planar images at 1hr and 4 hrs post injection of 99m Tc-HL91 in all tumor models. At same time inflammatory lesions cannot be seen clearly. Neoplasm can be seen in delayed phase in 99m Tc-MIBI groups, but not easy to distinguish them from inflammation. Conclusion: Compared with 99m Tc-MIBI imaging, 99m Tc-HL91 has much more diagnostic value in detection of solid neoplasm, and can distinguish neoplasm from inflammation

Cytotoxicity, Antiproliferative Effects, and Apoptosis Induction of Methanolic Extract of Cynometra cauliflora Linn. Whole Fruit on Human Promyelocytic Leukemia HL-60 Cells

Directory of Open Access Journals (Sweden)

T-Johari S. A. Tajudin

2012-01-01

Full Text Available Methanolic extract of Cynometra cauliflora whole fruit was assayed for cytotoxicity against the human promyelocytic leukemia HL-60 and the normal mouse fibroblast NIH/3T3 cell lines by using the MTT assay. The CD50 of the extract for 72 hours was 0.9 μg/mL whereas the value for the cytotoxic drug vincristine was 0.2 μg/mL. The viability of the NIH/3T3 cells was at 80.0% when treated at 15.0 μg/mL. The extract inhibited HL-60 cell proliferation with dose dependence. AO/PI staining of HL-60 cells treated with the extract revealed that majority of cells were in the apoptotic cell death mode. Flow cytometry analysis of HL-60 cells treated at CD50 of the extract showed that the early apoptotic cells were 31.0, 26.3 and 19.9% at 24, 48, and 72 hours treatment, respectively. The percentage of late apoptotic cells was increased from 62.0 at 24 hours to 64.1 and 70.2 at 48 and 72 hours, respectively. Meanwhile, percent of necrotic cells were 4.9, 6.6, and 8.5 at 24, 48, and 72 hours, respectively. This study has shown that the methanolic extract of C. cauliflora whole fruit was cytotoxic towards HL-60 cells and induced the cells into apoptotic cell death mode, but less cytotoxic towards NIH/3T3 cells.

High-Luminosity Large Hadron Collider (HL-LHC) Technical Design Report V. 0.1

CERN Document Server

Béjar Alonso I.; Brüning O.; Fessia P.; Lamont M.; Rossi L.; Tavian L.

2017-01-01

The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a newenergy frontier for exploration in 2010, it has gathered a global user community of about 7,000 scientists work-ing in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. Tosustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase itsinstantaneous luminosity (rate of collisions) by a factor of five beyond the original design value and the integratedluminosity (total collisions created) by a factor ten. The LHC is already a highly complex and exquisitely opti-mised machine so this upgrade must be carefully conceived and will require about ten years to implement. Thenew configuration, known as High Luminosity LHC (HL-LHC), relies on a number of key innovations that pushaccelerator technology beyond its present limits. Among these are cutting-edge 11-12 tesla superconducting mag-nets, compact superconduc...

CHIANTI—AN ATOMIC DATABASE FOR EMISSION LINES. XII. VERSION 7 OF THE DATABASE

International Nuclear Information System (INIS)

Landi, E.; Del Zanna, G.; Mason, H. E.; Young, P. R.; Dere, K. P.

2012-01-01

The CHIANTI spectral code consists of an atomic database and a suite of computer programs to calculate the optically thin spectrum of astrophysical objects and carry out spectroscopic plasma diagnostics. The database includes atomic energy levels, wavelengths, radiative transition probabilities, collision excitation rate coefficients, and ionization and recombination rate coefficients, as well as data to calculate free-free, free-bound, and two-photon continuum emission. Version 7 has been released, which includes several new ions, significant updates to existing ions, as well as Chianti-Py, the implementation of CHIANTI software in the Python programming language. All data and programs are freely available at http://www.chiantidatabase.org, while the Python interface to CHIANTI can be found at http://chiantipy.sourceforge.net.

CHIANTI-AN ATOMIC DATABASE FOR EMISSION LINES. XII. VERSION 7 OF THE DATABASE

Energy Technology Data Exchange (ETDEWEB)

Landi, E. [Department of Atmospheric, Oceanic and Space Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Del Zanna, G.; Mason, H. E. [Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom); Young, P. R. [College of Science, George Mason University, 4400 University Drive, Fairfax, VA, 22030 (United States); Dere, K. P. [School of Physics, Astronomy and Computational Sciences, MS 6A2, George Mason University, 4400 University Drive, Fairfax, VA 22030 (United States)

2012-01-10

The CHIANTI spectral code consists of an atomic database and a suite of computer programs to calculate the optically thin spectrum of astrophysical objects and carry out spectroscopic plasma diagnostics. The database includes atomic energy levels, wavelengths, radiative transition probabilities, collision excitation rate coefficients, and ionization and recombination rate coefficients, as well as data to calculate free-free, free-bound, and two-photon continuum emission. Version 7 has been released, which includes several new ions, significant updates to existing ions, as well as Chianti-Py, the implementation of CHIANTI software in the Python programming language. All data and programs are freely available at http://www.chiantidatabase.org, while the Python interface to CHIANTI can be found at http://chiantipy.sourceforge.net.

Design and fabrication of the NASA HL-20 support cradle and interior mockup

Science.gov (United States)

Exum, Thurman

1991-01-01

An extensive test program involving analysis in both the horizontal and vertical attitudes of the HL-20 will be conducted by NASA-Langley. This necessitated the fabrication of a steel support cradle for the composite Personnel Launch System (PLS) model and an internal mockup to simulate the pilot and passenger compartments.

[Ca2+]i in exterior of cells effected on apoptosis of HL-60 cells induced by irradiation

International Nuclear Information System (INIS)

He Ziyi; Meng Qingyong

2005-01-01

Objective: To investigate of the different [Ca 2+ ]i in exterior of cells promotion function on apoptosis of HL-60 cells induced by irradiation. Methods: To put ration dose 32 P and different [Ca 2+ ]i into culture of HL-60 and measure the apoptosis rate with FCM after 24 and 48 hours. Result: Apoptosis rate increased with the increase of [Ca 2+ ]i which shows an obvious function to promote apoptosis, r 24 =0.9001 (P=0.0145); r48=0.9343 (P=0.0063). Conclusion: [Ca 2+ ]i in exterior of cells has a obvious function in promoteing apoptosis induced by irradiation. (authors)

Associative Memory pattern matching for L1 track trigger for the HL-LHC CMS

CERN Document Server

Fedi, Giacomo

2016-01-01

The High Luminosity LHC (HL-LHC) will deliver a luminosity of up to $5 × 10^{34}cm^{−2}s^{−1}$, with an average of about 140 overlapping proton-proton collisions per bunch crossing. These extreme pileup conditions place stringent requirements on the trigger system to be able to cope with the resulting event rates. A key component of the CMS upgrade for HL-LHC is a track trigger system, able to identify tracks with transverse momenta above 2 GeV/c already at the first-level trigger. We present here the status of the implementation of a prototype system, based on the combination of Associative Memory custom ASIC and modern Field Programmable Gate Array (FPGA) devices, with the purpose to demonstrate the concept based on state-of-the-art technologies, and to direct the efforts of the necessary R&D toward a final system.

Several versions of forward gas ionization calorimeter

International Nuclear Information System (INIS)

Babintsev, V.V.; Kholodenko, A.G.; Rodnov, Yu.V.

1994-01-01

The properties of several versions of a gas ionization calorimeter are analyzed by means of the simulation with the GEANT code. The jet energy and coordinate resolutions are evaluated. Some versions of the forward calorimeter meet the ATLAS requirements. 13 refs., 15 figs., 7 tabs

Validation of the Urdu version of the Epworth Sleepiness Scale.

Science.gov (United States)

Surani, Asif Anwar; Ramar, Kannan; Surani, Arif Anwar; Khaliqdina, Jehangir Shehryar; Subramanian, Shyam; Surani, Salim

2012-09-01

To translate and validate the Epworth Sleepiness Scale (ESS) for use in Urdu-speaking population. The original Epworth Sleepiness Scale was translated into the Urdu version (ESS-Ur) in three phases - translation and back-translation; committee-based translation; and testing in bilingual individuals. The final was subsequently tested on 89 healthy bilingual subjects between February and April, 2010, to assess the validity of the translation compared to the original version. The subjects were students and employees of Dow University of Health Sciences, Karachi. Both English and Urdu versions of the Epworth Sleepiness Scale were administered to 59 (67%) women and 30 (33%) men. The mean composite Epworth score was 7.53 in English language and 7.7 in the Urdu version (p=0.76). The translated version was found to be highly correlated with the original scale (rho=0.938; pscale's Urdu version as an effective tool for measuring daytime sleepiness in Urdu-speaking population. Future studies assessing the validity of such patients with sleep disorders need to be undertaken.

A Statistical Review of CALIOP Version 3 and Version 4 Cloud Aerosol Discrimination

Science.gov (United States)

Zeng, S.

2016-12-01

The Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) on board the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) mission has now delivered a 10-year record of high-resolution profiles of backscatter at 532 nm and 1064 nm and linear depolarization at 532 nm. These long-term active sensor measurements at global scale have led to significant advances in our understanding of the vertical distribution of clouds and aerosols in the atmosphere. In the fall of 2016, the CALIPSO science team is scheduled to release a new version of their cloud and aerosol data products. The new cloud and aerosol discrimination products are derived using updated probability density functions that account for numerous improvements to the CALIOP calibration and the use of the GMAO MERRA-2 meteorological data. Moreover, the CAD algorithm is now applied to all layers detected, thus greatly improving the identification of such features as overshooting convective clouds, stratospheric aerosol layers, and high intensity dust storms. Post-processing modules are added to the standard CAD algorithm to ensure proper identification of (for example) the tenuous edges of cirrus clouds and water clouds lying beneath optically dense smoke layers. This work presents statistical comparisons between the CALIOP version 3 and version 4 data sets. Areas of improvement are highlighted, sources of continuing uncertainty are discussed and a list of best practices for data users is provided.

Nano-hole induction by nanodiamond and nanoplatinum liquid, DPV576, reverses multidrug resistance in human myeloid leukemia (HL60/AR

Directory of Open Access Journals (Sweden)

Ghoneum A

2013-07-01

Full Text Available Alia Ghoneum,1,2 Shivani Sharma,1,3 James Gimzewsk1,3 1Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, 2Department of Otalaryngology, Drew University of Medicine and Science, Los Angeles, 3California Nanosystems Institute (CNSI at University of California, Los Angeles, Los Angeles, CA, USA Abstract: Recently nanoparticles have been extensively studied and have proven to be a promising candidate for cancer treatment and diagnosis. In the current study, we examined the chemo-sensitizing activity of a mixture of nanodiamond (ND and nanoplatinum (NP solution known as DPV576, against multidrug-resistant (MDR human myeloid leukemia (HL60/AR and MDR-sensitive cells (HL60. Cancer cells were cultured with different concentrations of daunorubicin (DNR (1 × 10-9–1 × 10-6 M in the presence of selected concentrations of DPV576 (2.5%–10% v/v. Cancer cell survival was determined by MTT assay, drug accumulation by flow cytometry and confocal laser scanning microscopy (CLSM, and holes and structural changes by atomic force microscopy (AFM. Co-treatment of HL60/AR cells with DNR plus DPV576 resulted in the reduction of the IC50 to 1/4th. This was associated with increased incidences of holes inside the cells as compared with control untreated cells. On the other hand, HL60 cells did not show changes in their drug accumulation post-treatment with DPV576 and DNR. We conclude that DPV576 is an effective chemo-sensitizer as indicated by the reversal of HL60/AR cells to DNR and may represent a potential novel adjuvant for the treatment of chemo-resistant human myeloid leukemia. Keywords: nanodiamond, nanoplatinum, daunorubicin, flow cytometry, AFM

Dieter Möhl (1936–2012)

CERN Multimedia

2012-01-01

It is with great emotion and deep sadness that we learnt of the loss of our colleague and friend Dieter Möhl on 24 May. An accelerator physicist of world reputation, he made essential contributions to many projects at CERN and around the world. Here at CERN his name will remain forever linked with the success of the antiproton programme from its very beginning, but he also made substantial contributions to the FAIR project in Germany and to many other storage rings where beam cooling was an essential ingredient. His theoretical work was unique for the understanding, improvement and extension of beam cooling techniques to many accelerators and storage rings.   He was one of the pioneers who demonstrated by the Initial Cooling Experiment (ICE) that stochastic cooling was a viable proposition. This was essential for the approval of the CERN antiproton programme and its success.  Then, he was a leading member of the team which initiated and designed the Low Energy Antiproton Rin...

Integrated simulation tools for collimation cleaning in HL-LHC

CERN Document Server

Bruce, R; Cerutti, F; Ferrari, A; Lechner, A; Marsili, A; Mirarchi, D; Ortega, P G; Redaelli, S; Rossi, A; Salvachua, B; Sinuela, D P; Tambasco, C; Vlachoudis, V; Mereghetti, A; Assmann, R; Lari, L; Gibson, S M; Nevay, LJ; Appleby, R B; Molson, J; Serluca, M; Barlow, R J; Rafique, H; Toader, A

2014-01-01

The Large Hadron Collider is designed to accommodate an unprecedented stored beam energy of 362 MJ in the nominal configuration and about the double in the high-luminosity upgrade HL-LHC that is presently under study. This requires an efficient collimation system to protect the superconducting magnets from quenches. During the design, it is therefore very important to accurately predict the expected beam loss distributions and cleaning efficiency. For this purpose, there are several ongoing efforts in improving the existing simulation tools or developing new ones. This paper gives a brief overview and status of the different available codes.

SKP2 siRNA inhibits the degradation of P27kip1 and down-regulates the expression of MRP in HL-60/A cells.

Science.gov (United States)

Xiao, Jie; Yin, Songmei; Li, Yiqing; Xie, Shuangfeng; Nie, Danian; Ma, Liping; Wang, Xiuju; Wu, Yudan; Feng, Jianhong

2009-08-01

S-phase kinase-associated protein 2 (SKP2) gene is a tumor suppressor gene, and is involved in the ubiquitin-mediated degradation of P27kip1. SKP2 and P27kip1 affect the proceeding and prognosis of leukemia through regulating the proliferation, apoptosis and differentiation of leukemia cells. In this study, we explored the mechanism of reversing of HL-60/A drug resistance through SKP2 down-regulation. HL-60/A cells were nucleofected by Amaxa Nucleofector System with SKP2 siRNA. The gene and protein expression levels of Skp2, P27kip1, and multi-drug resistance associated protein (MRP) were determined by reverse transcription-polymerase chain reaction and western blot analysis, respectively. The cell cycle was analyzed by flow cytometry. The 50% inhibitory concentration value was calculated using cytotoxic analysis according to the death rate of these two kinds of cells under different concentrations of chemotherapeutics to compare the sensitivity of the cells. HL-60/A cells showed multi-drug resistance phenotype characteristic by cross-resistance to adriamycin, daunorubicin, and arabinosylcytosine, due to the expression of MRP. We found that the expression of SKP2 was higher in HL-60/A cells than in HL-60 cells, but the expression of P27kip1 was lower. The expression of SKP2 in HL-60/A cells nucleofected by SKP2 siRNA was down-regulated whereas the protein level of P27kip1 was up-regulated. Compared with the MRP expression level in the control group (nucleofected by control siRNA), the mRNA and protein expression levels of MRP in HL-60/A cells nucleofected by SKP2 siRNA were lower, and the latter cells were more sensitive to adriamycin, daunorubicin, and arabinosylcytosine. Down-regulating the SKP2 expression and arresting cells in the G0/G1 phase improve drug sensitivity of leukemia cells with down-regulated MRP expression.

Will LHCb run in the HL-LHC era?

International Nuclear Information System (INIS)

Schmidt, B.

2012-01-01

The LHCb collaboration presented a Letter of Intent to the LHCC in March 2011 for upgrading the detector during LS2 (2018) and intends to collect a data sample of 50 fb -1 in the LHC and HL-LHC eras. The physics case and the strategy for the upgrade have been endorsed by the LHCC. This paper presents briefly the physics motivations for the LHCb upgrade and the proposed changes to the detector and trigger. In the following part machine related issues for the LHCb upgrade are discussed, in particular issues in relation to the Target Absorber for Secondaries (TAS), Radiation to Electronics (R2E), β* and crossing angle in IP8. (author)

An improved version of the HULLAC code

Energy Technology Data Exchange (ETDEWEB)

Busquet, M.; Bar-Shalom, A.; Klapisch, M.; Oreg, J. [ARTEPARTEP is a contractor to the Naval Research Lab., Washington, DC (United States)

2006-06-15

Accurate and detailed atomic structure codes are needed for simulation of spectrally resolved X-ray output of laser driven target. As such, the HULLAC code has already been presented several times. First of all, an overhaul was performed, modernizing many parts to make them easier to understand and adding many comments. The source, in Fortran-77, was compiled and checked on many different systems with different compilers. In the new version, we have added the possibility to directly compute the relativistic configuration averages, skipping the fine structure. However in this case configuration interactions can be accounted for only within each non-relativistic configuration. Therefore we added the possibility of a mixed description, where not all configurations are described at the fine structure level. Recently, cooperation was proposed to anyone interested in extending or developing the code. HULLAC is now ready to be distributed on a basis of collaboration.

An improved version of the HULLAC code

International Nuclear Information System (INIS)

Busquet, M.; Bar-Shalom, A.; Klapisch, M.; Oreg, J.

2006-01-01

Accurate and detailed atomic structure codes are needed for simulation of spectrally resolved X-ray output of laser driven target. As such, the HULLAC code has already been presented several times. First of all, an overhaul was performed, modernizing many parts to make them easier to understand and adding many comments. The source, in Fortran-77, was compiled and checked on many different systems with different compilers. In the new version, we have added the possibility to directly compute the relativistic configuration averages, skipping the fine structure. However in this case configuration interactions can be accounted for only within each non-relativistic configuration. Therefore we added the possibility of a mixed description, where not all configurations are described at the fine structure level. Recently, cooperation was proposed to anyone interested in extending or developing the code. HULLAC is now ready to be distributed on a basis of collaboration

Pumping and leak detection system of the HL-2A

International Nuclear Information System (INIS)

Cao Zeng; Xu Yunxian; Fu Weidong

2001-01-01

The pumping system is a combination of 8 turbomolecular pumps with three stages pumping for HL-2A vacuum vessel, a total effective pumping speed at the vessel of 12 m 3 ·s -1 for nitrogen. The leak detection of element and vessel is performed with inspiration, case of leak detection and two mass spectrometry. The total leak rate of vessel is bellow 1 x 10 -5 Pa ·m 3 ·s -1 . The base pressure is 1 x 10 -5 Pa

HECTR Version 1.5 user's manual

International Nuclear Information System (INIS)

Dingman, S.E.; Camp, A.L.; Wong, C.C.; King, D.B.; Gasser, R.D.

1986-04-01

This report describes the use and features of HECTR Version 1.5. HECTR is a relatively fast-running, lumped-volume containment analysis computer program that is most useful for performing parametric studies. The main purpose of HECTR is to analyze nuclear reactor accidents involving the transport and combustion of hydrogen, but HECTR can also function as an experiment analysis tool and can solve a limited set of other types of containment problems. New models added to HECTR Version 1.5 include fan coolers, containment leakage, continuous burning, and the capability to treat carbon monoxide and carbon dioxide. Models for the ice condenser, sumps, and Mark III suppression pool were upgraded. HECTR is designed for flexibility and provides for user control of many important parameters, particularly those related to hydrogen combustion. Built-in correlations and default values of key parameters are also provided

An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program.

Science.gov (United States)

Tasseff, Ryan; Jensen, Holly A; Congleton, Johanna; Dai, David; Rogers, Katharine V; Sagar, Adithya; Bunaciu, Rodica P; Yen, Andrew; Varner, Jeffrey D

2017-10-30

In this study, we present an effective model All-Trans Retinoic Acid (ATRA)-induced differentiation of HL-60 cells. The model describes reinforcing feedback between an ATRA-inducible signalsome complex involving many proteins including Vav1, a guanine nucleotide exchange factor, and the activation of the mitogen activated protein kinase (MAPK) cascade. We decomposed the effective model into three modules; a signal initiation module that sensed and transformed an ATRA signal into program activation signals; a signal integration module that controlled the expression of upstream transcription factors; and a phenotype module which encoded the expression of functional differentiation markers from the ATRA-inducible transcription factors. We identified an ensemble of effective model parameters using measurements taken from ATRA-induced HL-60 cells. Using these parameters, model analysis predicted that MAPK activation was bistable as a function of ATRA exposure. Conformational experiments supported ATRA-induced bistability. Additionally, the model captured intermediate and phenotypic gene expression data. Knockout analysis suggested Gfi-1 and PPARg were critical to the ATRAinduced differentiation program. These findings, combined with other literature evidence, suggested that reinforcing feedback is central to hyperactive signaling in a diversity of cell fate programs.

Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations

International Nuclear Information System (INIS)

Tanaka, M.; Kimura, K.; Yoshida, S.

1983-01-01

The exposure of HL-60 human promyelocytic leukemia cells to 0.5 microM 5-fluoro-2'-[ 3 H]deoxyuridine (FdUrd) for 16 hr resulted in the incorporation of 5.14 +/- 0.31 (S.D.) X 10(-7) mol FdUrd into DNA per mol of DNA nucleotide, which corresponds to 0.146 +/- 0.082 pmol FdUrd per 10(7) cells. Pretreatment with 50 microM deoxythymidine for 24 hr led to a 2.7-fold increase in the incorporation of this analogue into newly synthesized DNA during the ensuing 16-hr exposure to 0.5 microM [ 3 H]FdUrd. Pretreatment with 0.5 microM methotrexate for 3 hr also increased the [ 3 H]FdUrd incorporation into newly synthesized DNA approximately 5-fold. The coexistence of deoxythymidine or methotrexate with [ 3 H]FdUrd, however, led to decreased incorporation of FdUrd into DNA. More than 50% of the radioactivity in DNA separated by Cs2SO4 equilibrium density gradient centrifugation was proven to be fluorodeoxyuridylate by means of its binding to Lactobacillus casei deoxythymidine monophosphate synthetase

TOUGH2 User's Guide Version 2

International Nuclear Information System (INIS)

Pruess, K.; Oldenburg, C.M.; Moridis, G.J.

1999-01-01

TOUGH2 is a numerical simulator for nonisothermal flows of multicomponent, multiphase fluids in one, two, and three-dimensional porous and fractured media. The chief applications for which TOUGH2 is designed are in geothermal reservoir engineering, nuclear waste disposal, environmental assessment and remediation, and unsaturated and saturated zone hydrology. TOUGH2 was first released to the public in 1991; the 1991 code was updated in 1994 when a set of preconditioned conjugate gradient solvers was added to allow a more efficient solution of large problems. The current Version 2.0 features several new fluid property modules and offers enhanced process modeling capabilities, such as coupled reservoir-wellbore flow, precipitation and dissolution effects, and multiphase diffusion. Numerous improvements in previously released modules have been made and new user features have been added, such as enhanced linear equation solvers, and writing of graphics files. The T2VOC module for three-phase flows of water, air and a volatile organic chemical (VOC), and the T2DM module for hydrodynamic dispersion in 2-D flow systems have been integrated into the overall structure of the code and are included in the Version 2.0 package. Data inputs are upwardly compatible with the previous version. Coding changes were generally kept to a minimum, and were only made as needed to achieve the additional functionalities desired. TOUGH2 is written in standard FORTRAN77 and can be run on any platform, such as workstations, PCs, Macintosh, mainframe and supercomputers, for which appropriate FORTRAN compilers are available. This report is a self-contained guide to application of TOUGH2 to subsurface flow problems. It gives a technical description of the TOUGH2 code, including a discussion of the physical processes modeled, and the mathematical and numerical methods used. Illustrative sample problems are presented along with detailed instructions for preparing input data

Decay constants in soft wall AdS/QCD revisited

Directory of Open Access Journals (Sweden)

Nelson R.F. Braga

2016-12-01

We show here that a modified framework of soft wall AdS/QCD involving an additional dimensionfull parameter, associated with an ultraviolet energy scale, provides decay constants decreasing with radial excitation level. In this version of the soft wall model the two point function of gauge theory operators is calculated at a finite position of the anti-de Sitter space radial coordinate.

Design and construction of high-frequency magnetic probe system on the HL-2A tokamak

Science.gov (United States)

Liang, S. Y.; Ji, X. Q.; Sun, T. F.; Xu, Yuan; Lu, J.; Yuan, B. S.; Ren, L. L.; Yang, Q. W.

2017-12-01

A high-frequency magnetic probe system is designed, calibrated and constructed on the HL-2A tokamak. To investigate the factors which affect the probe frequency response, the inductance and capacitance in the probe system are analyzed using an equivalent circuit. Suitable sizes and turn number of the coil, and the length of transmission cable are optimized based on the theory and detailed test in the calibration. To deal with the frequency response limitation and bake-out, the ceramic grooved technique is used and the probe is wound with a bare copper wire. A cascade filter is manufactured with a suitable bandwidth as well as a good phase consistency between channels. The system has been used in the experiment to measure high frequency (≤300 kHz) magnetohydrodynamic fluctuations, which can meet the requirement of physical analysis on HL-2A.

Identification of chimpanzee leukocyte antigens (ChL-A) and their relation to HL-A

NARCIS (Netherlands)

Balner, H.

1971-01-01

The identification of a number of leukocyte antigens of chimpanzees is described. Suggestive evidence was obtained that some of the isoantisera recognize specificities of a hypothetical genetic system of chimpanzee antigens which, in analogy with the human HL-A system, is tentatively called ChL-A.

Snake perturbations during pellet injection and LHCD in the HL-1M tokamak

International Nuclear Information System (INIS)

Liu Yi; Qiu Xiaoming; Dong Yunbo; Guo Gangcheng; Xiao Zhengui; Zhong Yunzhe; Zheng Yinjia; Fu Bingzhong; Dong Jiafu; Liu Yong; Wang Enyao

2004-01-01

Excitation of snake perturbations has been observed in the core region of pellet-fuelled HL-1M plasmas when the pellets cross the surface with a q value of 1. It is observed that the snake oscillations have an m = 1, n = 1 helicity with quite a long lifetime. A detailed comparison has been made between the locations of the q = 1 surface and the snake oscillation. Through measurements of the plasma q-profile by means of multi-exposures with a CCD camera during pellet ablation, and investigation of the pellet ablation process, possible mechanisms for the formation of the snake oscillation are discussed. In addition, a large, long-lived snake-like oscillation is frequently observed in lower-hybrid current driven (LHCD) discharge in which the sawtooth has been stabilized early in the discharge. There is evidence that such a perturbation is due to impurity accumulation during sawtooth-stabilization, and good performance with peaking profiles after LHCD is limited by magnetohydrodynamic instabilities including sawtooth and snake activities in HL-1M plasmas

Study of the Polarization Strategy for Electron Cyclotron Heating Systems on HL-2M

Science.gov (United States)

Zhang, F.; Huang, M.; Xia, D. H.; Song, S. D.; Wang, J. Q.; Huang, B.; Wang, H.

2016-06-01

As important components integrated in transmission lines of electron cyclotron heating systems, polarizers are mainly used to obtain the desired polarization for highly efficient coupling between electron cyclotron waves and plasma. The polarization strategy for 105-GHz electron cyclotron heating systems of HL-2M tokamak is studied in this paper. Considering the polarizers need high efficiency, stability, and low loss to realize any polarization states, two sinusoidal-grooved polarizers, which include a linear polarizer and an elliptical polarizer, are designed with the coordinate transformation method. The parameters, the period p and the depth d, of two sinusoidal-grooved polarizers are optimized by a phase difference analysis method to achieve an almost arbitrary polarization. Finally, the optimized polarizers are manufactured and their polarization characteristics are tested with a low-power test platform. The experimental results agree well with the numerical calculations, indicating that the designed polarizers can meet the polarization requirements of the electron cyclotron heating systems of HL-2M tokamak.

Induction of apoptosis by Citrus paradisi essential oil in human leukemic (HL-60) cells.

Science.gov (United States)

Hata, Tomona; Sakaguchi, Ikuyo; Mori, Masahiro; Ikeda, Norikazu; Kato, Yoshiko; Minamino, Miki; Watabe, Kazuhito

2003-01-01

Limonene is a primary component of citrus essential oils (EOs) and has been reported to induce apoptosis on tumor cells. Little is known about induction of apoptosis by citrus EOs. In this study, we examined induction of apoptosis by Citrus aurantium var. dulcis (sweet orange) EO, Citrus paradisi (grapefruit) EO and Citrus limon (lemon) EO. These EOs induced apoptosis in HL-60 cells and the apoptosis activities were related to the limonene content of the EOs. Moreover, sweet orange EO and grapefruit EO may contain components besides limonene that have apoptotic activity. To identify the components with apoptotic activity, grapefruit EO was fractionated using silica gel columns, and the components were analyzed by GC-MS. The n-hexane fraction contained limonene, and the dichloromethane fraction (DF) contained aldehyde compounds and nootkatone. Decanal, octanal and citral in the DF showed strong apoptotic activity, suggesting that the aldehyde compounds induced apoptosis strongly in HL-60 cells.

A new high sensitivity far-infrared laser interferometer for the HL-2A tokamak

Science.gov (United States)

Li, Y. G.; Zhou, Y.; Li, Y.; Deng, Z. C.; Wang, H. X.; Yi, J.

2017-08-01

A new four-chord Michelson-type formic acid (HCOOH, λ = 432.5 μm) laser interferometer has been successfully commissioned on the HL-2A tokamak to measure the electron density and density fluctuations. Due to the employment of the two-laser heterodyne technique, the time resolution of the interferometer reached 1.0 microseconds (μs). Four chords of line electron densities with a line-averaged density resolution 2 × 1016/m3 were obtained in a recent HL-2A experimental campaign, and detailed electron density fluctuations, caused by events such as edge localized mode, sawtooth precursor-oscillations, and energetic particle driven instabilities, were distinctly measured. In particular, the high-frequency electron density fluctuations (up to 500 kHz) caused by the reversed shear Alfvénic eigenmode were observed by the internal two interferometry channels, and their fluctuation location could be approximately identified from the spectra characteristics of multi-chord line electron densities.

Antileukemic Potential of Momordica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells

Directory of Open Access Journals (Sweden)

Ramani Soundararajan

2012-01-01

Full Text Available Momordica charantia (bitter gourd has been used in the traditional system of medicine for the treatment of various diseases. Anticancer activity of M. charantia extracts has been demonstrated by numerous in vitro and in vivo studies. In the present study, we investigated the differentiation inducing potential of fractionated M. charantia seed extracts in human myeloid HL60 cells. We found that the HL60 cells treated with the fractionated seed extracts differentiated into granulocytic lineage as characterized by NBT staining, CD11b expression, and specific esterase activity. The differentiation inducing principle was found to be heat-stable, and organic in nature. The differentiation was accompanied by a downregulation of c-myc transcript, indicating the involvement of c-myc pathway, at least in part, in differentiation. Taken together these results indicate that fractionated extracts of M. charantia seeds possess differentiation inducing activity and therefore can be evaluated for their potential use in differentiation therapy for leukemia in combination with other inducers of differentiation.

Antileukemic Potential of Momordica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells

Science.gov (United States)

Soundararajan, Ramani; Prabha, Punit; Rai, Umesh; Dixit, Aparna

2012-01-01

Momordica charantia (bitter gourd) has been used in the traditional system of medicine for the treatment of various diseases. Anticancer activity of M. charantia extracts has been demonstrated by numerous in vitro and in vivo studies. In the present study, we investigated the differentiation inducing potential of fractionated M. charantia seed extracts in human myeloid HL60 cells. We found that the HL60 cells treated with the fractionated seed extracts differentiated into granulocytic lineage as characterized by NBT staining, CD11b expression, and specific esterase activity. The differentiation inducing principle was found to be heat-stable, and organic in nature. The differentiation was accompanied by a downregulation of c-myc transcript, indicating the involvement of c-myc pathway, at least in part, in differentiation. Taken together these results indicate that fractionated extracts of M. charantia seeds possess differentiation inducing activity and therefore can be evaluated for their potential use in differentiation therapy for leukemia in combination with other inducers of differentiation. PMID:22654956

FORM version 4.0

Science.gov (United States)

Kuipers, J.; Ueda, T.; Vermaseren, J. A. M.; Vollinga, J.

2013-05-01

We present version 4.0 of the symbolic manipulation system FORM. The most important new features are manipulation of rational polynomials and the factorization of expressions. Many other new functions and commands are also added; some of them are very general, while others are designed for building specific high level packages, such as one for Gröbner bases. New is also the checkpoint facility, that allows for periodic backups during long calculations. Finally, FORM 4.0 has become available as open source under the GNU General Public License version 3. Program summaryProgram title: FORM. Catalogue identifier: AEOT_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEOT_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public License, version 3 No. of lines in distributed program, including test data, etc.: 151599 No. of bytes in distributed program, including test data, etc.: 1 078 748 Distribution format: tar.gz Programming language: The FORM language. FORM itself is programmed in a mixture of C and C++. Computer: All. Operating system: UNIX, LINUX, Mac OS, Windows. Classification: 5. Nature of problem: FORM defines a symbolic manipulation language in which the emphasis lies on fast processing of very large formulas. It has been used successfully for many calculations in Quantum Field Theory and mathematics. In speed and size of formulas that can be handled it outperforms other systems typically by an order of magnitude. Special in this version: The version 4.0 contains many new features. Most important are factorization and rational arithmetic. The program has also become open source under the GPL. The code in CPC is for reference. You are encouraged to upload the most recent sources from www.nikhef.nl/form/formcvs.php because of frequent bug fixes. Solution method: See "Nature of Problem", above. Additional comments: NOTE: The code in CPC is for reference. You are encouraged

Cross-Layer Service Discovery Mechanism for OLSRv2 Mobile Ad Hoc Networks

Directory of Open Access Journals (Sweden)

M. Isabel Vara

2015-07-01

Full Text Available Service discovery plays an important role in mobile ad hoc networks (MANETs. The lack of central infrastructure, limited resources and high mobility make service discovery a challenging issue for this kind of network. This article proposes a new service discovery mechanism for discovering and advertising services integrated into the Optimized Link State Routing Protocol Version 2 (OLSRv2. In previous studies, we demonstrated the validity of a similar service discovery mechanism integrated into the previous version of OLSR (OLSRv1. In order to advertise services, we have added a new type-length-value structure (TLV to the OLSRv2 protocol, called service discovery message (SDM, according to the Generalized MANET Packet/Message Format defined in Request For Comments (RFC 5444. Each node in the ad hoc network only advertises its own services. The advertisement frequency is a user-configurable parameter, so that it can be modified depending on the user requirements. Each node maintains two service tables, one to store information about its own services and another one to store information about the services it discovers in the network. We present simulation results, that compare our service discovery integrated into OLSRv2 with the one defined for OLSRv1 and with the integration of service discovery in Ad hoc On-demand Distance Vector (AODV protocol, in terms of service discovery ratio, service latency and network overhead.

Cross-Layer Service Discovery Mechanism for OLSRv2 Mobile Ad Hoc Networks.

Science.gov (United States)

Vara, M Isabel; Campo, Celeste

2015-07-20

Service discovery plays an important role in mobile ad hoc networks (MANETs). The lack of central infrastructure, limited resources and high mobility make service discovery a challenging issue for this kind of network. This article proposes a new service discovery mechanism for discovering and advertising services integrated into the Optimized Link State Routing Protocol Version 2 (OLSRv2). In previous studies, we demonstrated the validity of a similar service discovery mechanism integrated into the previous version of OLSR (OLSRv1). In order to advertise services, we have added a new type-length-value structure (TLV) to the OLSRv2 protocol, called service discovery message (SDM), according to the Generalized MANET Packet/Message Format defined in Request For Comments (RFC) 5444. Each node in the ad hoc network only advertises its own services. The advertisement frequency is a user-configurable parameter, so that it can be modified depending on the user requirements. Each node maintains two service tables, one to store information about its own services and another one to store information about the services it discovers in the network. We present simulation results, that compare our service discovery integrated into OLSRv2 with the one defined for OLSRv1 and with the integration of service discovery in Ad hoc On-demand Distance Vector (AODV) protocol, in terms of service discovery ratio, service latency and network overhead.

The preliminary studies of HL-1 plasma with pump limiter

International Nuclear Information System (INIS)

Ran, L.B.; Li, G.D.; Sum, S.Q.

1991-01-01

Reduction of the impurity and control of the density are very important task in the present tokamak research. Some experiments showed that the pump limiter is effective to improve impurity and density control. A small-scale pump limiter has been installed on HL-1 tokamak in 1990 and the experiment has been carried out firstly with hydrogen ohmic discharge. In this paper we would present the improvements of the plasma properties as the pump limiter was main limiter and the movable limiter was auxiliary limiter. (author) 3 refs., 8 figs

Estimated Sensitivity for New Particle Searches at the HL-LHC

CERN Document Server

CMS Collaboration

2017-01-01

Sensitivity projections for new physics searches with 3000 $\\mathrm{fb}^{-1}$ of data anticipated at the high-luminosity LHC (HL-LHC) are presented. These results were obtained from dedicated studies performed for the ECFA 2016 upgrade workshop. Projections for heavy vector bosons (Z$'$ and W$'$) decays containing top quarks are obtained by extrapolating Run-2 results assuming scenarios with varying systematic uncertainties. Results for the dark matter and weak production of single vector-like quark searches are obtained by implementing detector performance specifications from the CMS Phase-2 technical proposal in the DELPHES simulation package.

Silicon Strip Detectors for ATLAS at the HL-LHC Upgrade

CERN Document Server

Hara, K; The ATLAS collaboration

2012-01-01

The present ATLAS silicon strip (SCT) and transition radiation (TRT) trackers will be replaced with new silicon strip detectors, as part of the Inner Tracker System (ITK), for the Phase-2 upgrade of the Large Hadron Collider, HL-LHC. We have carried out intensive R&D programs to establish radiation harder strip detectors that can survive in a radiation level up to 3000 fb-1 of integrated luminosity based on n+-on-p microstrip detector. We describe main specifications for this year’s sensor fabrication, followed by a description of possible module integration schema

Design for the excitation systems of three generator sets of HL-2A

International Nuclear Information System (INIS)

Li Huajun; Xu Lirong; Liu Xuemei; You Tianxue

2001-01-01

The design for the excitation systems have been made on the basis of respective features and load demands of three motor-generator sets of HL-2A. The excitation systems of No.1 and No.2 generator sets which supply for toroidal field are discussed in detail and three feasible excitation plans have been proposed according to the investment

The κ-(AdS quantum algebra in (3+1 dimensions

Directory of Open Access Journals (Sweden)

Ángel Ballesteros

2017-03-01

Full Text Available The quantum duality principle is used to obtain explicitly the Poisson analogue of the κ-(AdS quantum algebra in (3+1 dimensions as the corresponding Poisson–Lie structure on the dual solvable Lie group. The construction is fully performed in a kinematical basis and deformed Casimir functions are also explicitly obtained. The cosmological constant Λ is included as a Poisson–Lie group contraction parameter, and the limit Λ→0 leads to the well-known κ-Poincaré algebra in the bicrossproduct basis. A twisted version with Drinfel'd double structure of this κ-(AdS deformation is sketched.

The inside outs of AdS{sub 3}/CFT{sub 2}: exact AdS wormholes with entangled CFT duals

Energy Technology Data Exchange (ETDEWEB)

Mandal, Gautam; Sinha, Ritam; Sorokhaibam, Nilakash [Department of Theoretical Physics, Tata Institute of Fundamental Research,Mumbai 400005 (India)

2015-01-09

We present the complete family of solutions of 3D gravity (Λ<0) with two asymptotically AdS exterior regions. The solutions are constructed from data at the two boundaries, which correspond to two independent and arbitrary stress tensors T{sub R},T-bar{sub R}, and T{sub L},T-bar{sub L}. The two exteriors are smoothly joined on to an interior region through a regular horizon. We find CFT duals of these geometries which are entangled states of two CFT’s. We compute correlators between general operators at the two boundaries and find perfect agreement between CFT and bulk calculations. We calculate and match the CFT entanglement entropy (EE) with the holographic EE which involves geodesics passing through the wormhole. We also compute a holographic, non-equilibrium entropy for the CFT using properties of the regular horizon. The construction of the bulk solutions here uses an exact version of Brown-Henneaux type diffeomorphisms which are asymptotically nontrivial and transform the CFT states by two independent unitary operators on the two sides. Our solutions provide an infinite family of explicit examples of the ER=EPR relation of Maldacena and Susskind http://dx.doi.org/10.1002/prop.201300020.

Validation of the Spanish Version of the Addenbrooke's Cognitive Examination-Revised (ACE-R).

Science.gov (United States)

Torralva, T; Roca, M; Gleichgerrcht, E; Bonifacio, A; Raimondi, C; Manes, F

2011-01-01

The Addenbrooke's Cognitive Examination Revised (ACE-R) is an improved version of the earlier brief screening test which has been validated in English with high sensitivity and specificity to detect cognitive dysfunction. The aim of this study was to validate the Spanish version of the ACE-R in an Argentine population. A group of patients with Alzheimer Disease (AD) and patients with behavioural variant Frontotemporal Dementia (bvFTD) paired by age, sex, and years of education with healthy controls were assessed using the ACE-R. Stage of dementia was measured with the Clinical Dementia Rating Scale (CDR). The English version of the ACE-R was first translated into Spanish and then back-translated into English by two blind independent experts. Internal reliability was very good (Cronbach's alpha=0.89). Concurrent validity, determined by the correlation between total ACE-R and CDR was significant (Pcognitive impairment and has shown to discriminate between bvFTD and AD. Copyright © 2010 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

Investigation of plasma equilibrium in HL-1 tokamak

International Nuclear Information System (INIS)

Lu Zhihong; Jiang Yunxia; Yang Jinwei; Zhang Baozhu; Qiu Wei; Qin Yunwen

1987-01-01

In this paper, the plasma equilibrium in HL-1 tokamak has been discussed. The horizontal and vertical displacement of plasma is measured using a symmetical magneic probe system, and the temporal evolution of displacements is given by a data acquisition system with micro-computer. The influence of various stray fields on plasma equilibrium has been analysed. The direction and value of horizontal stray field induced by the totoidal field coils and primary windings are determined using vertical displacement data. By adjusting parameters of internal and external vertical field, in the flat part of discharge current, the plasma can be kept in its equilibuium state at the place where is 3 cm outer of chamber certre, i.e nearby the centre of limiter

Validation of a cutoff for the Depression Scale of the Center for Epidemiologic Studies, Brief Version (CESD-7).

OpenAIRE

Aarón Salinas-Rodríguez; Betty Manrique-Espinoza; Isaac Acosta-Castillo; Martha Ma. Téllez-Rojo; Aurora Franco-Núñez; Luis Miguel Gutiérrez-Robledo; Ana Luisa Sosa-Ortiz

2013-01-01

Objective. To evaluate the Depression Scale of the Center for Epidemiologic Studies, Brief Version (CESD-7) psychometric properties in Mexican adult population, and validate a cutoff for classifying subjects according to the presence / absence of clinically significant depressive symptoms (CSDS). Materials and methods. Screening cross-sectional study with a subsample of 301 adult residents of the Morelos state in Mexico, originally interviewed for the National Survey of Health and Nutrition 2...

Preliminary physical design of 7 MeV proton RFQ for the accelerator driven-energy system

International Nuclear Information System (INIS)

Luo Zihua

2000-01-01

The preliminary physical design of 7 MeV proton RFQ for the ADS (Accelerator Driven-energy System) is briefly described. The design features and the basic parameters and the design version of the RFQ are discussed. The matches between IS and RFQ and between RFQ and CCDTL/DTL are also discussed. The ideas of research for the RFQ are presented

Conceptual design of HL-2M tokamak control system

International Nuclear Information System (INIS)

Xia Fan; Chen Liaoyuan; Song Xianming; Zhang Jinhua; Lou Cuiwen; Pan Yudong

2009-01-01

The static architecture, dynamic behavior, control theory and simulation of HL-2M tokamak control system are described. The real-time network will be build for the communication of real-time control among its subsystems and universal timing system will be build to guarantee the synchronization among the subsystems. The duty to achieve preprogrammed parameters is carried out by plasma discharge control. In order to reduce the damage made by discharge exception, the error-handing mechanism of supervision system is considered. The controllers of magnetic control system are designed to control the current, shape and position of plasma and simulation system is designed for testing the controllers. (authors)

Measuring health literacy among low literate people: an exploratory feasibility study with the HLS-EU questionnaire

Directory of Open Access Journals (Sweden)

Hannelore Storms

2017-05-01

Full Text Available Abstract Background Health literacy (HL is defined as necessary competencies to make well-informed decisions. As patients’ decision making is a key element of patient-centered health care, insight in patients’ HL might help healthcare professionals to organize their care accordingly. This is particularly true for people in a vulnerable situation, potentially with limited HL, who are, for instance, at greater risk of having limited access to care [1, 2]. As HL correlates with education, instruments should allow inclusion of low literate people. To that end, the relatively new instrument, HLS-EU-Q47, was subjected to a comprehensibility test, its shorter version, HLS-EU-Q16, was not. Therefore, the goal of this study was to examine feasibility of HLS-EU-Q16 (in Dutch for use in a population of people with low literacy. Methods Purposive sampling of adults with low (yearly income (< €16,965.47 and limited education (maximum high school, with Dutch language proficiency. Exclusion criteria were: psychiatric, neurodegenerative diseases or impairments. To determine suitability (length, comprehension and layout participants were randomly distributed either HLS-EU-Q16 or a modified version and were interviewed directly afterwards by one researcher. To determine feasibility a qualitative approach was chosen: cognitive interviews were carried out using the verbal probing technique. Results Thirteen participants completed HLS-EU-Q16 (n = 7 or the modified version (n = 6. Questions about ‘disease prevention’ or ‘appraisal’ of information are frequently reported to be incomprehensible. Difficulties are attributed to vocabulary, sentence structure and the decision process (abstraction, distinguishing ‘appraising’ from ‘applying’ information, indecisive on the appropriate response. Conclusions HLS-EU-Q16 is a suitable instrument to determine HL in people with limited literacy. However, to facilitate the use and interpretation, some

Upgrade plans for the ATLAS Forward Calorimeter at the HL-LHC

Science.gov (United States)

Rutherfoord, John; ATLAS Liquid Argon Calorimeter Group

2012-12-01

Although data-taking at CERN's Large Hadron Collider (LHC) is expected to continue for a number of years, plans are already being developed for operation of the LHC and associated detectors at an increased instantaneous luminosity about 5 times the original design value of 1034 cm-2 s-1. The increased particle flux at this high luminosity (HL) will have an impact on many sub-systems of the ATLAS detector. In particular, in the liquid argon forward calorimeter (FCal), which was designed for operation at LHC luminosities, the associated increase in the ionization load at HL-LHC luminosities creates a number of problems which can degrade its performance. These include space-charge effects in the liquid argon gaps, excessive drop in potential across the gaps due to large HV supply currents through the protection resistors, and an increase in temperature which may cause the liquid argon to boil. One solution, which would require opening both End-Cap cryostats, is the construction and installation of new FCals with narrower liquid argon gaps, lowering the values of the protection resistors, and the addition of cooling loops. A second proposed solution, which does not require opening the cryostat cold volume, is the addition of a small, warm calorimeter in front of each existing FCal, resulting in a reduction of the particle flux to levels at which the existing FCal can operate normally.

A pattern recognition mezzanine based on associative memory and FPGA technology for L1 track triggering at HL-LHC

International Nuclear Information System (INIS)

Alunni, L.; Biesuz, N.; Bilei, G.M.; Citraro, S.; Crescioli, F.; Fanò, L.; Fedi, G.; Magalotti, D.; Magazzù, G.; Servoli, L.; Storchi, L.; Palla, F.; Placidi, P.; Papi, A.; Piadyk, Y.; Rossi, E.; Spiezia, A.

2016-01-01

The increase of luminosity at HL-LHC will require the introduction of tracker information at Level-1 trigger system for the experiments to maintain an acceptable trigger rate to select interesting events despite the one order of magnitude increase in the minimum bias interactions. To extract in the required latency the track information a dedicated hardware has to be used. We present the tests of a prototype system (Pattern Recognition Mezzanine) as core of pattern recognition and track fitting for HL-LHC ATLAS and CMS experiments, combining the power of both Associative Memory custom ASIC and modern Field Programmable Gate Array (FPGA) devices.

A pattern recognition mezzanine based on associative memory and FPGA technology for L1 track triggering at HL-LHC

Science.gov (United States)

Alunni, L.; Biesuz, N.; Bilei, G. M.; Citraro, S.; Crescioli, F.; Fanò, L.; Fedi, G.; Magalotti, D.; Magazzù, G.; Servoli, L.; Storchi, L.; Palla, F.; Placidi, P.; Papi, A.; Piadyk, Y.; Rossi, E.; Spiezia, A.

2016-07-01

The increase of luminosity at HL-LHC will require the introduction of tracker information at Level-1 trigger system for the experiments to maintain an acceptable trigger rate to select interesting events despite the one order of magnitude increase in the minimum bias interactions. To extract in the required latency the track information a dedicated hardware has to be used. We present the tests of a prototype system (Pattern Recognition Mezzanine) as core of pattern recognition and track fitting for HL-LHC ATLAS and CMS experiments, combining the power of both Associative Memory custom ASIC and modern Field Programmable Gate Array (FPGA) devices.

A pattern recognition mezzanine based on associative memory and FPGA technology for L1 track triggering at HL-LHC

Energy Technology Data Exchange (ETDEWEB)

Alunni, L. [INFN Sezione di Perugia (Italy); Biesuz, N. [INFN Sezione di Pisa (Italy); Bilei, G.M. [INFN Sezione di Perugia (Italy); Citraro, S. [Università di Pisa, Pisa (Italy); Crescioli, F. [LPNHE, Paris (France); Fanò, L. [INFN Sezione di Perugia (Italy); Fedi, G., E-mail: giacomo.fedi@pi.infn.it [INFN Sezione di Pisa (Italy); Magalotti, D. [INFN Sezione di Perugia (Italy); UNIMORE, Modena (Italy); Magazzù, G. [INFN Sezione di Pisa (Italy); Servoli, L.; Storchi, L. [INFN Sezione di Perugia (Italy); Palla, F. [INFN Sezione di Pisa (Italy); Placidi, P. [INFN Sezione di Perugia (Italy); DIEI, Perugia (Italy); Papi, A. [INFN Sezione di Perugia (Italy); Piadyk, Y. [LPNHE, Paris (France); Rossi, E. [INFN Sezione di Pisa (Italy); Spiezia, A. [IHEP (China)

2016-07-11

The increase of luminosity at HL-LHC will require the introduction of tracker information at Level-1 trigger system for the experiments to maintain an acceptable trigger rate to select interesting events despite the one order of magnitude increase in the minimum bias interactions. To extract in the required latency the track information a dedicated hardware has to be used. We present the tests of a prototype system (Pattern Recognition Mezzanine) as core of pattern recognition and track fitting for HL-LHC ATLAS and CMS experiments, combining the power of both Associative Memory custom ASIC and modern Field Programmable Gate Array (FPGA) devices.

Adult Autism Subthreshold Spectrum (AdAS Spectrum): Validation of a questionnaire investigating subthreshold autism spectrum.

Science.gov (United States)

Dell'Osso, L; Gesi, C; Massimetti, E; Cremone, I M; Barbuti, M; Maccariello, G; Moroni, I; Barlati, S; Castellini, G; Luciano, M; Bossini, L; Rocchetti, M; Signorelli, M; Aguglia, E; Fagiolini, A; Politi, P; Ricca, V; Vita, A; Carmassi, C; Maj, M

2017-02-01

Increasing literature has shown the usefulness of a dimensional approach to autism. The present study aimed to determine the psychometric properties of the Adult Autism Subthreshold Spectrum (AdAS Spectrum), a new questionnaire specifically tailored to assess subthreshold forms of autism spectrum disorder (ASD) in adulthood. 102 adults endorsing at least one DSM-5 symptom criterion for ASD (ASDc), 143 adults diagnosed with a feeding and eating disorder (FED), and 160 subjects with no mental disorders (CTL), were recruited from 7 Italian University Departments of Psychiatry and administered the following: SCID-5, Autism-Spectrum Quotient (AQ), Ritvo Autism and Asperger Diagnostic Scale 14-item version (RAADS-14), and AdAS Spectrum. The AdAS Spectrum demonstrated excellent internal consistency for the total score (Kuder-Richardson's coefficient=.964) as well as for five out of seven domains (all coefficients>.80) and sound test-retest reliability (ICC=.976). The total and domain AdAS Spectrum scores showed a moderate to strong (>.50) positive correlation with one another and with the AQ and RAADS-14 total scores. ASDc subjects reported significantly higher AdAS Spectrum total scores than both FED (pcriteria (FED 0 ) and those with one ASD symptom criterion (FED 1 ) , a gradient of severity in AdAS Spectrum scores from CTL subjects to ASD patients, across FED 0 , ASD 1 , FED 1 was shown. The AdAS Spectrum showed excellent internal consistency and test-retest reliability and strong convergent validity with alternative dimensional measures of ASD. The questionnaire performed differently among the three diagnostic groups and enlightened some significant effects of gender in the expression of autistic traits. Copyright © 2016 Elsevier Inc. All rights reserved.

Version pressure feedback mechanisms for speculative versioning caches

Science.gov (United States)

Eichenberger, Alexandre E.; Gara, Alan; O& #x27; Brien, Kathryn M.; Ohmacht, Martin; Zhuang, Xiaotong

2013-03-12

Mechanisms are provided for controlling version pressure on a speculative versioning cache. Raw version pressure data is collected based on one or more threads accessing cache lines of the speculative versioning cache. One or more statistical measures of version pressure are generated based on the collected raw version pressure data. A determination is made as to whether one or more modifications to an operation of a data processing system are to be performed based on the one or more statistical measures of version pressure, the one or more modifications affecting version pressure exerted on the speculative versioning cache. An operation of the data processing system is modified based on the one or more determined modifications, in response to a determination that one or more modifications to the operation of the data processing system are to be performed, to affect the version pressure exerted on the speculative versioning cache.

Utilization of the human cell line HL-60 for chemiluminescence based detection of microorganisms and related substances

DEFF Research Database (Denmark)

Timm, Michael; Hansen, Erik W; Moesby, Lise

2006-01-01

species (ROS) when challenged with pyrogenic substances. In a luminol enhanced chemilumimetric assay the responsiveness of differentiated HL-60 cells is tested towards Salmonella typhimurium, Bacillus subtilis, Saccharomyces cerevisiae, Candida albicans, lipopolysaccharide (LPS) and lipoteichoic acid (LTA......). The results show a poor sensitivity to S. typhimurium but displays good sensitivity towards B. subtilis, LTA and LPS. Furthermore, the sensitivity towards the yeasts C. albicans and S. cerevisiae is considerably better than obtained in other in vitro cell systems. Overall these results indicate that the HL-60...... cell assay possibly could be evolved to a supplementary assay for the known pyrogenic detection assays. Furthermore, the utilization of the assay for pyrogenic examination of recombinant drugs derived from yeast expression systems would be relevant to examine....

Machine Protection Challenges for HL-LHC

CERN Document Server

Schmidt, R; Wenninger, J; Wollmann, D; Zerlauth, M

2014-01-01

LHC operation requires the flawless functioning of the machine protection systems. The energy stored in the beam was progressively increased beyond the 140 MJ range at the end of 2012 at 4 TeV/c. The further increase to more than 300 MJ expected for 2015 at 6.5 TeV/c should be possible with the existing protection systems. For HL-LHC additional failure modes need to be considered. The stored beam energy will increase by another factor of two with respect to nominal and a factor of five more than experienced so far. The maximum beta function in the high luminosity insertion regions will increase. It is planned to install crab cavities in the LHC to compensate for the loss in luminosity due to the crossing-angle. With crab cavities, sudden voltage decays within 100 µs after e.g. cavity quenches can lead to large transverse beam oscillations. Tracking simulations predict trajectory distortions of up to 1.5 σ after a sudden drop of the deflecting voltage in a single cavity. Protons in the halo with an energy of...

Prototype HL-LHC magnet undergoes testing

CERN Multimedia

Corinne Pralavorio

2016-01-01

A preliminary short prototype of the quadrupole magnets for the High-Luminosity LHC has passed its first tests.   The first short prototype of the quadrupole magnet for the High Luminosity LHC. (Photo: G. Ambrosio (US-LARP and Fermilab), P. Ferracin and E. Todesco (CERN TE-MSC)) Momentum is gathering behind the High-Luminosity LHC (HL-LHC) project. In laboratories on either side of the Atlantic, a host of tests are being carried out on the various magnet models. In mid-March, a short prototype of the quadrupole magnet underwent its first testing phase at the Fermilab laboratory in the United States. This magnet is a pre-prototype of the quadrupole magnets that will be installed near to the ATLAS and CMS detectors to squeeze the beams before collisions. Six quadrupole magnets will be installed on each side of each experiment, giving a total of 24 magnets, and will replace the LHC's triplet magnets. Made of superconducting niobium-tin, the magnets will be more powerful than their p...

Coldbox installation for HL-LHC crab cavity test in the SPS tunnel (BA6)

CERN Document Server

Ordan, Julien Marius

2018-01-01

The Cold-box, produced by Linde Kryotechnik for the SPS crab-cavity test stand for HL-LHC, on its arrival at CERN. It wll be transported into the tunnel in horizontal position and then will have to be tilted in its operational position, on its vertical axis, before connecting it to cryogenics lines.

Free-Spinning-Tunnel Investigation of a 0.034-Scale Model of the Production Version of the Chance Vought F7U-3 Airplane, TED No. NACA AD 3103

Science.gov (United States)

Klinar, Walter J.; Healy, Frederick M.

1955-01-01

An investigation of a 0.034-scale model of the production version of the Chance Vought F7U-3 airplane has been conducted in the Langley 20-foot free-spinning tunnel. The inverted and erect spin and recovery characteristics of the model were determined for the combat loading with the model in the clean condition and the effect of extending slats was investigated. A brief investigation of pilot ejection was also performed. The results indicate that the inverted spin-recovery characteristics of the airplane will be satisfactory by full rudder reversal. If the rudders can only be neutralized because of high pedal forces in the inverted spins, satisfactory recovery will be obtained if the auxiliary rudders can be moved to neutral or against the spin provided the stick is held full forward. Optimum control technique for satisfactory recovery from erect spins will be full rudder reversal in conjunction with aileron movement to full with the spin (stick right in a right spin). Extension of the slats will have a slightly adverse effect on recoveries from (1 inverted spins but will have a favorable effect on recoveries from erect spins. The results of brief tests indicate that if a pilot is ejected during a spin while a spin-recovery parachute is extended and fully inflated, he will probably clear the tail parachute.

99mTc-HL91 SPECT detects the relation between hypoxic changes and radiotherapy response of lung cancer

International Nuclear Information System (INIS)

Li Ling; Yu Jinming; Xing Ligang; Zhu Hui; Li Guoliang; Fang Yongcun

2006-01-01

Objective: To evaluate relation between hypoxia, hypoxic changes detected by 99m Tc-HL91 SPECT and the response to radiotherapy. Methods: Thirty-five patients with pathologically proven non-small cell lung cancer (NSCLC) treated by three-dimensional conformal radiotherapy were entered into the study. All patients were examined by examined by 99m Tc-HL9l SPECT imaging one or two days before radiotherapy. Twenty patients were monitored during radiotherapy(30-40 Gy) and one or two days after radiotherapy. Anterior', posterior and lateral planar images were collected 2 hours, 4 hours and 6 hours after intravenous injection approximately 740 MBq 99m Tc-HL91. Regions of interest(ROIs) were ch awn in the tumor and contralateral position and the radioactivity ratios of tumor to normal(T/N) were calculated. The response to radiotherapy was evaluated by solid tumor' s effect evaluation criterion (WHO) 3-6 months after radiotherapy. The correlations between T/N before radiotherapy, the T/N changes during radiotherapy and the response to radiotherapy were analyzed. Results: The T/N value gradually decreased before, during and after radiotherapy. The average T/N value before, during and after radiotherapy was 1.56±0.19, 1.40±0.12 and 1.29±0.13, respectively (F=10.13, P=0.010). The lower T/N ratio be- fore radiotherapy, the higher the response rate of radiotherapy (P=0.040). The larger change of T/N ratio before and after radiotherapy resulted in higher radiotherapy response, but with no statistical significance (P>0.05). Conclusions: The hypoxia status and hypoxic changes can be observed by HL91 SPECT imaging during radiotherapy which can predict the response to radiotherapy. (authors)

PLANETARY SYSTEM FORMATION IN THE PROTOPLANETARY DISK AROUND HL TAURI

Energy Technology Data Exchange (ETDEWEB)

Akiyama, Eiji; Hasegawa, Yasuhiro; Hayashi, Masahiko; Iguchi, Satoru, E-mail: eiji.akiyama@nao.ac.jp, E-mail: yasuhiro.hasegawa@nao.ac.jp [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan)

2016-02-20

We reprocess the Atacama Large Millimeter/Submillimeter Array (ALMA) long-baseline science verification data taken toward HL Tauri. Assuming the observed gaps are opened up by currently forming, unseen bodies, we estimate the mass of such hypothetical bodies based on the following two approaches: the Hill radius analysis and a more elaborate approach developed from the angular momentum transfer analysis in gas disks. For the former, the measured gap widths are used for estimating the mass of the bodies, while for the latter, the measured gap depths are utilized. We show that their masses are comparable to or less than the mass of Jovian planets. By evaluating Toomre’s gravitational instability (GI) condition and cooling effect, we find that the GI might be a mechanism to form the bodies in the outer region of the disk. As the disk might be gravitationally unstable only in the outer region of the disk, inward planetary migration would be needed to construct the current architecture of the observed disk. We estimate the gap-opening mass and show that type II migration might be able to play such a role. Combining GIs with inward migration, we conjecture that all of the observed gaps may be a consequence of bodies that might have originally formed at the outer part of the disk, and have subsequently migrated to the current locations. While ALMA’s unprecedented high spatial resolution observations can revolutionize our picture of planet formation, more dedicated observational and theoretical studies are needed to fully understand the HL Tauri images.

PLANETARY SYSTEM FORMATION IN THE PROTOPLANETARY DISK AROUND HL TAURI

International Nuclear Information System (INIS)

Akiyama, Eiji; Hasegawa, Yasuhiro; Hayashi, Masahiko; Iguchi, Satoru

2016-01-01

We reprocess the Atacama Large Millimeter/Submillimeter Array (ALMA) long-baseline science verification data taken toward HL Tauri. Assuming the observed gaps are opened up by currently forming, unseen bodies, we estimate the mass of such hypothetical bodies based on the following two approaches: the Hill radius analysis and a more elaborate approach developed from the angular momentum transfer analysis in gas disks. For the former, the measured gap widths are used for estimating the mass of the bodies, while for the latter, the measured gap depths are utilized. We show that their masses are comparable to or less than the mass of Jovian planets. By evaluating Toomre’s gravitational instability (GI) condition and cooling effect, we find that the GI might be a mechanism to form the bodies in the outer region of the disk. As the disk might be gravitationally unstable only in the outer region of the disk, inward planetary migration would be needed to construct the current architecture of the observed disk. We estimate the gap-opening mass and show that type II migration might be able to play such a role. Combining GIs with inward migration, we conjecture that all of the observed gaps may be a consequence of bodies that might have originally formed at the outer part of the disk, and have subsequently migrated to the current locations. While ALMA’s unprecedented high spatial resolution observations can revolutionize our picture of planet formation, more dedicated observational and theoretical studies are needed to fully understand the HL Tauri images

Silicon Strip detectors for the ATLAS End-Cap Tracker at the HL-LHC

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00232570

Inside physics programme of the LHC different experiment upgrades are foreseen. After the phase-II upgrade of the ATLAS detector the luminosity will be increased up to 5-7.5x10E34 cm-2s-1. This will mean a considerable increase in the radiation levels, above 10E16 neq/cm2 in the inner regions. This thesis is focused on the development of silicon microstrip detectors enough radiation hard to cope with the particle fluence expected at the ATLAS detector during HL-LHC experiment. In particular on the electrical characterization of silicon sensors for the ATLAS End-Caps. Different mechanical and thermal tests are shown using a Petal core as well as the electrical characterization of the silicon sensors that will be used with the Petal structure. Charge collection efficiency studies are carried out on sensors with different irradiation fluences using the ALiBaVa system and two kinds of strips connection are also analized (DC and AC ganging) with a laser system. The Petalet project is presented and the electrical c...

A High-Granularity Timing Detector (HGTD) in ATLAS: Performance at the HL-LHC

CERN Document Server

Makovec, Nikola; The ATLAS collaboration

2017-01-01

The expected increase of the particle flux at the high luminosity phase of the LHC (HL-LHC) with instantaneous luminosities up to L ≃ 7.5 × 1034 cm−2 s−1 will have a severe impact on the ATLAS deetctor performance. The pile-up is expected to increase on average to 200 interactions per bunch crossing resulting in a vertex density that can be larger than 1.5 per mm. The reconstruction and performance for electrons, photons, jets and transverse missing energy will be severely degraded in the end-cap and forward region, where the liquid Argon based electromagnetic calorimeter has coarser granularity compared to the central region. The High Granularity Timing Detector (HGTD) is proposed in front of the liquid Argon end-cap calorimeters for pile-up mitigation. Using the high granularity and the excellent timing capabilities of the detector with 30 ps per MIP, electron and jet reconstruction (b tagging) are presented as well as the impact on the pileup jet suppression and missing ET. The expected improvement ...

Specifications of the Field Quality at Injection Energy of the New Magnets for the HL-LHC Upgrade Project

CERN Document Server

De Maria, R; Giovannozzi, M

2013-01-01

The HL-LHC project relies on new magnet designs and technologies to achieve very small beta* values. In particular, Nb$_{3}$Sn magnets show large allowed multipole imperfections at low current. These field imperfections may have a non-negligible impact on the dynamic aperture and beam life time in the HL-LHC, also because of the smaller-than- nominal beta* values foreseen IR1 and IR5 at injection energy, which aims at decreasing the dynamic range of the squeeze and therefore contributing to optimize the turn around time. The paper describes an analysis of the machine performance based on analytical estimates and tracking simulations with the goal of providing field quality specifications for the new magnets.

Prospects for a precision timing upgrade of the CMS PbWO crystal electromagnetic calorimeter for the HL-LHC

Science.gov (United States)

Massironi, A.

2018-04-01

The upgrade of the Compact Muon Solenoid (CMS) crystal electromagnetic calorimeter (ECAL), which will operate at the High Luminosity Large Hadron Collider (HL-LHC), will achieve a timing resolution of around 30 ps for high energy photons and electrons. In this talk we will discuss the benefits of precision timing for the ECAL event reconstruction at HL-LHC. Simulation studies focused on the timing properties of PbWO4 crystals, as well as the impact of the photosensors and the readout electronics on the timing performance, will be presented. Test beam studies intended to measure the timing performance of the PbWO4 crystals with different photosensors and readout electronics will be shown.

Prospects for a precision timing upgrade of the CMS PbWO crystal electromagnetic calorimeter for the HL-LHC

CERN Document Server

Massironi, Andrea

2017-01-01

The upgrade of the Compact Muon Solenoid (CMS) crystal electromagnetic calorimeter (ECAL), which will operate at the High Luminosity Large Hadron Collider (HL-LHC), will achieve a timing resolution of around 30 ps for high energy photons and electrons. In this talk we will discuss the benefits of precision timing for the ECAL event reconstruction at HL-LHC. Simulation studies focused on the timing properties of PbWO$_4$ crystals, as well as the impact of the photosensors and the readout electronics on the timing performance, will be presented. Test beam studies intended to measure the timing performance of the PbWO$_4$ crystals with different photosensors and readout electronics will be shown.

Task 7: ADPAC User's Manual

Science.gov (United States)

Hall, E. J.; Topp, D. A.; Delaney, R. A.

1996-01-01

The overall objective of this study was to develop a 3-D numerical analysis for compressor casing treatment flowfields. The current version of the computer code resulting from this study is referred to as ADPAC (Advanced Ducted Propfan Analysis Codes-Version 7). This report is intended to serve as a computer program user's manual for the ADPAC code developed under Tasks 6 and 7 of the NASA Contract. The ADPAC program is based on a flexible multiple- block grid discretization scheme permitting coupled 2-D/3-D mesh block solutions with application to a wide variety of geometries. Aerodynamic calculations are based on a four-stage Runge-Kutta time-marching finite volume solution technique with added numerical dissipation. Steady flow predictions are accelerated by a multigrid procedure. An iterative implicit algorithm is available for rapid time-dependent flow calculations, and an advanced two equation turbulence model is incorporated to predict complex turbulent flows. The consolidated code generated during this study is capable of executing in either a serial or parallel computing mode from a single source code. Numerous examples are given in the form of test cases to demonstrate the utility of this approach for predicting the aerodynamics of modem turbomachinery configurations.

The VTRx+, an optical link module for data transmission at HL-LHC

CERN Document Server

Troska, Jan; Detraz, Stephane; Kraxner, Andrea; Olanterä, Lauri; Scarcella, Carmelo; Sigaud, Christophe; Soos, Csaba; Vasey, Francois

2017-01-01

Optical data transmission will remain a key enabling technology for the upgrading detectors at HL-LHC. In particular the inner tracking detectors will require low-mass, radiation tolerant optical transmit and receive modules for tight integration in the detector front-ends. We describe the development of such a module, giving details of the design, functional and environmental performance, as well as showing the feasibility of achieving small size, low-mass, and low-power operation.

Dynamical Stability of Imaged Planetary Systems in Formation: Application to HL Tau

OpenAIRE

Tamayo, Daniel; Triaud, Amaury H. M. J.; Menou, Kristen; Rein, Hanno

2015-01-01

A recent ALMA image revealed several concentric gaps in the protoplanetary disk surrounding the young star HL Tau. We consider the hypothesis that these gaps are carved by planets, and present a general framework for understanding the dynamical stability of such systems over typical disk lifetimes, providing estimates for the maximum planetary masses. We collect these easily evaluated constraints into a workflow that can help guide the design and interpretation of new observational campaigns ...

New Searching Capability and OpenURL Linking in the ADS

Science.gov (United States)

Eichhorn, Guenther; Accomazzi, A.; Grant, C. S.; Henneken, E.; Kurtz, M. J.; Thompson, D. M.; Murray, S. S.

2006-12-01

The ADS is the search system of choice for the astronomical community. It also covers a large part of the physics and physics/astronomy education literature. In order to make access to this system as easy as possible, we developed a Google-like interface version of our search form. This one-field search parses the user input and automatically detects author names and year ranges. Firefox users can set up their browser to have this search field installed in the top right corner search field to have even easier access to the ADS search capability. The basic search is available from the ADS Homepage at: http://adsabs.harvard.edu To aid with access to subscription journals the ADS now supports OpenURL linking. If your library supports an OpenURL server, you can specify this server in the ADS preference settings. All links to journal articles will then automatically be directed to the OpenURL with the appropriate link information. We provide a selection of known OpenURL servers to choose from. If your server is not in this list, please send the necessary information to ads@cfa.harvard.edu and we will include it in our list. The ADS is funded by NASA grant NNG06GG68G.

Investigation on HL-1M pellet shape and cloud structure

International Nuclear Information System (INIS)

Zheng Yinjia

2001-01-01

When hydrogen multi-pellet flied out from the gun exit and was injected into the HL-1M plasma, the pellet injection and ablation cloud were observed by using a 2D CCD camera SensiCam 360LF. The shape of flight pellet from the gun exit was obtained with the photos taken. The pellet ablation process and the structure of its cloud were analyzed by means of photos with multiple exposure (exp. 100 ns) and long exposure. The experimental setup is described, the results of the pellet injection experiment and characteristic of ablation cloud are presented

Electronics for CMS Endcap Muon Level-1 Trigger System Phase-1 and HL LHC upgrades

Science.gov (United States)

Madorsky, A.

2017-07-01

To accommodate high-luminosity LHC operation at a 13 TeV collision energy, the CMS Endcap Muon Level-1 Trigger system had to be significantly modified. To provide robust track reconstruction, the trigger system must now import all available trigger primitives generated by the Cathode Strip Chambers and by certain other subsystems, such as Resistive Plate Chambers (RPC). In addition to massive input bandwidth, this also required significant increase in logic and memory resources. To satisfy these requirements, a new Sector Processor unit has been designed. It consists of three modules. The Core Logic module houses the large FPGA that contains the track-finding logic and multi-gigabit serial links for data exchange. The Optical module contains optical receivers and transmitters; it communicates with the Core Logic module via a custom backplane section. The Pt Lookup table (PTLUT) module contains 1 GB of low-latency memory that is used to assign the final Pt to reconstructed muon tracks. The μ TCA architecture (adopted by CMS) was used for this design. The talk presents the details of the hardware and firmware design of the production system based on Xilinx Virtex-7 FPGA family. The next round of LHC and CMS upgrades starts in 2019, followed by a major High-Luminosity (HL) LHC upgrade starting in 2024. In the course of these upgrades, new Gas Electron Multiplier (GEM) detectors and more RPC chambers will be added to the Endcap Muon system. In order to keep up with all these changes, a new Advanced Processor unit is being designed. This device will be based on Xilinx UltraScale+ FPGAs. It will be able to accommodate up to 100 serial links with bit rates of up to 25 Gb/s, and provide up to 2.5 times more logic resources than the device used currently. The amount of PTLUT memory will be significantly increased to provide more flexibility for the Pt assignment algorithm. The talk presents preliminary details of the hardware design program.

Extensions of MAD Version 8 to Include Beam Acceleration

International Nuclear Information System (INIS)

Raubenheimer, Tor O

2000-01-01

In this paper, the authors describe modifications to MAD version 8.23 to include linear accelerator cavities and beam acceleration. An additional energy variable has been added which is modified as the beam passes through LCAV elements (linear accelerator cavities) and can be used as a constraint in matching commands. The calculation of the beta functions and phase advance is consistent with that in other codes that treat acceleration such as TRANSPORT or DIMAD. These modifications allow this version of MAD to be used for the design and modeling of linacs and the authors present examples from the Next Linear Collider design as well as a muon acceleration complex. The code is available from CERN or SLAC

Cleaning of the first mirrors and diagnostic windows by YAG laser on HL-2A

International Nuclear Information System (INIS)

Zhou, Y; Zheng, L; Li, Y G; Li, L C; Jiao, Y M; Gao, H; Zhao, G

2009-01-01

A laser cleaning system for HL-2A tokamak first mirrors and diagnostic windows has been developed recently. A detailed description of the laser cleaning procedure is presented. The optical transmission performance measured before and after the laser cleaning of the impurity film deposited on the optical elements is investigated. HL-2A deposited layers on metal mirrors and glass windows with thicknesses of about 1 and 4 μm, respectively, are clearly removed by irradiation with a single pulse of a Q-switched Nd:YAG laser with energy density of 0.4 and 2.8 J cm -2 , respectively. The feasibility of cleaning ECE windows is demonstrated. A cleaning time of about 5 min is suitable for application in fusion devices. The comparison of results obtained at different laser wavelengths shows that there is a greater probability of damage to the metallic mirror surface with a short laser wavelength than with longer wavelength.

FATALIC: a fully integrated electronics readout for the ATLAS tile calorimeter at the HL-LHC

CERN Document Server

Angelidakis, Stylianos; The ATLAS collaboration

2018-01-01

The ATLAS Collaboration has started a vast program of upgrades in the context of high-luminosity LHC (HL-LHC) foreseen in 2024. The current readout electronics of every sub-detector, including the Tile Calorimeter (TileCal), must be upgraded to comply with the extreme HL-LHC operating conditions. The ASIC described in this document, named Front-end ATlAs tiLe Integrated Circuit (FATALIC), has been developed to fulfill these requirements. FATALIC is based on a $130\\,$nm CMOS technology and performs the complete processing of the signal, including amplification, shaping and digitization on a large dynamic range from $25\\,$fC to $1.2\\,$nC. The overall architecture of this current-reading ASIC is composed by current conveyors, shapers, 12-bits pipeline analog-to-digital converters operating at $40\\,$Mhz and a digital block dealing with the three gains implemented in this electronics. A dedicated channel for low current is also designed in order to be able to perform absolute calibration with radioactive cesium so...

FATALIC: a fully integrated electronics readout for the ATLAS tile calorimeter at the HL-LHC

CERN Document Server

Angelidakis, Stylianos; The ATLAS collaboration

2018-01-01

The ATLAS Collaboration has started a vast program of upgrades in the context of high-luminosity LHC (HL-LHC) foreseen in 2024. The current readout electronics of every sub-detector, including the Tile Calorimeter (TileCal), must be upgraded to comply with the extreme HL-LHC operating conditions. The ASIC described in this document, named Front-end ATlAs tiLe Integrated Circuit (FATALIC), has been developed to fulfill these requirements. FATALIC is based on a $130\\,$nm CMOS technology and performs the complete processing of the signal, including amplification, shaping and digitization on a large dynamic range A dedicated channel for low current is also designed in order to perform absolute calibration with radioactive cesium source, producing a known but low signal with a typical frequency of $100\\,$Hz. In this document, the design of FATALIC is described and the measured performances as well as results of tests using beam of particles at CERN are discussed.

Prospects for a precision timing upgrade of the CMS PbWO$_{4}$ crystal electromagnetic calorimeter for the HL-LHC

CERN Document Server

Marzocchi, Badder

2017-01-01

The upgrade of the Compact Muon Solenoid (CMS) crystal electromagnetic calorimeter (ECAL), which will operate at the High Luminosity Large Hadron Collider (HL-LHC), will achieve a timing resolution of around 30 ps for high energy photons and electrons. In this talk we will discuss the benefits of precision timing for the ECAL event reconstruction at HL-LHC. Simulation studies on the timing properties of PbWO crystals, as well as the impact of the photosensors and the readout electronics on the timing performance, will be presented. Test beam studies on the timing performance of PbWO$_{4}$ crystals with various photosensors and readout electronics will be shown.

An alternative path to the boundary: The CFT as the Fourier space of AdS

Science.gov (United States)

Tolfree, Ian M.

2009-12-01

In this thesis we shed new light on the conjectured duality between an n + 1 dimensional theory of gravity in anti de Sitter space (AdS) and an n dimensional conformal field theory (CFT) by showing that the CFT can be interpreted as the Fourier space of AdS. We then make use of this to gain insight into the nature of black hole entropy. In the first part of this thesis, we give an introduction to the ideas of and review the basics of the AdS/CFT. In the next section we make use of well known integral geometry techniques to derive the Fourier transformation of a function on AdS and see it is a function with compact support on the boundary. Comparing this to the literature, we find that the Green's functions from the literature are actually the Fourier weights of the transformation and that the boundary values of fields appearing in the correspondence are the Fourier coefficients of the transformation. One is thus left to interpret the CFT as the quantized version of a classical theory in AdS and the dual operator as the Fourier coefficients. Group theoretic considerations are discussed in relation to the transformation and its potential use in constructing QCD like theories. In the last section, we then build upon this to study the BTZ black hole. Named after its authors, Banados, Teitelboim and Zanelli, the BTZ black hole is a three dimensional (two space plus one time dimension) black hole in anti de Sitter space. Following standard procedures for modifying Fourier Transformations to accommodate quotient spaces we arrive at a mapping in a black hole background consistent with known results that yields the exact micro-states of a scalar field in a black hole background. We find that the micro-states are the Fourier coefficients on the boundary, which transform under the principal series representation of SL(2, R). Using the knowledge of how to represent a bulk scalar field in the CFT, and knowing how a black hole interacts with a scalar field, we deduce the

The Critical Role of Redox Homeostasis in Shikonin-Induced HL-60 Cell Differentiation via Unique Modulation of the Nrf2/ARE Pathway

Directory of Open Access Journals (Sweden)

Bo Zhang

2012-01-01

Full Text Available Among various cancer cell lines, the leukemia cell line HL-60 was most sensitive to Shikonin, with evidence showing both the prooxidative activities and proapoptotic effects of micromolar concentrations of Shikonin. However, the mechanism involved in the cytotoxicity of Shikonin in the submicromolar range has not been fully characterized. Using biochemical and free radical biological experiments in vitro, we identified the prodifferentiated profiles of Shikonin and evaluated the redox homeostasis during HL-60 differentiation. The data showed a strong dose-response relationship between Shikonin exposure and the characteristics of HL-60 differentiation in terms of morphology changes, nitroblue tetrazolium (NBT reductive activity, and the expression level of surface antigens CD11b/CD14. During drug exposure, intercellular redox homeostasis changes towards oxidation are necessary to support Shikonin-induced differentiation, which was proven by additional enzymatic and non-enzymatic redox modulators. A statistically significant and dose-dependent increase (P<0.05 was recorded with regard to the unique expression levels of the Nrf2/ARE downstream target genes in HL-60 cells undergoing late differentiation, which were restored with further antioxidants employed with the Shikonin treatment. Our research demonstrated that Shikonin is a differentiation-inducing agent, and its mechanisms involve the Nrf2/ARE pathway to modulate the intercellular redox homeostasis, thus facilitating differentiation.

Planetary Mission Entry Vehicles Quick Reference Guide. Version 3.0

Science.gov (United States)

Davies, Carol; Arcadi, Marla

2006-01-01

This is Version 3.0 of the planetary mission entry vehicle document. Three new missions, Re-entry F, Hayabusa, and ARD have been added to t he previously published edition (Version 2.1). In addition, the Huyge ns mission has been significantly updated and some Apollo data correc ted. Due to the changing nature of planetary vehicles during the desi gn, manufacture and mission phases, and to the variables involved in measurement and computation, please be aware that the data provided h erein cannot be guaranteed. Contact Carol Davies at cdavies@mail.arc. nasa.gov to correct or update the current data, or to suggest other missions.

Immunomodulatory effects of testosterone evaluated in all-trans retinoic acid differentiated HL-60 cells, granulocytes, and monocytes

DEFF Research Database (Denmark)

Boje, Alex; Moesby, Lise; Timm, Michael

2012-01-01

The sex hormones are known to affect innate immunity in humans. In this study we evaluated the immunomodulatory effects of testosterone in a model system comprising of all-trans retinoic acid differentiated HL-60 cells, and confirmed the results in human granulocytes and monocytes. Results showed...... that testosterone at pharmacological doses reduced the production of interleukin-8 and reactive oxygen species from differentiated HL-60 cells in a concentration dependent manner without affecting phagocytosis. The cells were stimulated with zymosan, lipopolysaccharide, or Bacillus subtilis. At the highest...... concentration of testosterone (120 µM), interleukin-8 secretion was reduced 42-80%, and production of reactive oxygen species was reduced 32-46%. Flutamide, an antagonist of the classical intracellular androgen receptor, was unable to antagonize the immunosuppressive effect of testosterone. We further...

The International Comparison of Value Added, Productivity and Purchasing Power Parities in Agriculture

NARCIS (Netherlands)

Maddison, Angus; Ooststroom, Harry van

1993-01-01

This study is part of the ICOP (International Comparison of Output and Productivity) project of the University of Groningen. It presents international comparisons of levels of value added, productivity and purchasing power parities (PPPs) in agriculture for 13 countries for 1975. An early version of

Mutagenesis at the ad-3A and ad-3B loci in haploid UV-sensitive strains of Neurospora crassa. Pt. 2

International Nuclear Information System (INIS)

Serres, F.J. de

1980-01-01

UV-induced inactivation and induction of mutations at the ad-3A and ad-3B loci of Neurospora crassa have been compared among 7 different UV-sensitive strains and a standard wild-type strain. The 7 strains show varying degrees of sensitivity to UV-induced inactivation, with the relative sensitivity being: uvs-2 > uvs-3 > uvs-4 > uvs-6 > upr-1 > uvs-5 > uvs-1. Studies on the induction of ad-3 mutants by UV show that the 2 excision-repair deficient mutants uvs-2 and upr-1 exhibit enhanced ad-3 mutant frequencies, while uvs-4 and uvs-5 exhibit reduced ad-3 mutant frequencies, and uvs-3 completely eliminates UV mutagenesis. The ad-3 mutation-induction curves obtained with uvs-1 or uvs-6 are not significantly different from that found with the wild-type strain. (orig.)

Upgrade plans for the ATLAS Forward Calorimeter at the HL-LHC

International Nuclear Information System (INIS)

Rutherfoord, John

2012-01-01

Although data-taking at CERN's Large Hadron Collider (LHC) is expected to continue for a number of years, plans are already being developed for operation of the LHC and associated detectors at an increased instantaneous luminosity about 5 times the original design value of 10 34 cm −2 s −1 . The increased particle flux at this high luminosity (HL) will have an impact on many sub-systems of the ATLAS detector. In particular, in the liquid argon forward calorimeter (FCal), which was designed for operation at LHC luminosities, the associated increase in the ionization load at HL-LHC luminosities creates a number of problems which can degrade its performance. These include space-charge effects in the liquid argon gaps, excessive drop in potential across the gaps due to large HV supply currents through the protection resistors, and an increase in temperature which may cause the liquid argon to boil. One solution, which would require opening both End-Cap cryostats, is the construction and installation of new FCals with narrower liquid argon gaps, lowering the values of the protection resistors, and the addition of cooling loops. A second proposed solution, which does not require opening the cryostat cold volume, is the addition of a small, warm calorimeter in front of each existing FCal, resulting in a reduction of the particle flux to levels at which the existing FCal can operate normally.

Enabling technologies for silicon microstrip tracking detectors at the HL-LHC

International Nuclear Information System (INIS)

Feld, L.; Karpinski, W.; Klein, K.

2016-04-01

While the tracking detectors of the ATLAS and CMS experiments have shown excellent performance in Run 1 of LHC data taking, and are expected to continue to do so during LHC operation at design luminosity, both experiments will have to exchange their tracking systems when the LHC is upgraded to the high-luminosity LHC (HL-LHC) around the year 2024. The new tracking systems need to operate in an environment in which both the hit densities and the radiation damage will be about an order of magnitude higher than today. In addition, the new trackers need to contribute to the first level trigger in order to maintain a high data-taking efficiency for the interesting processes. Novel detector technologies have to be developed to meet these very challenging goals. The German groups active in the upgrades of the ATLAS and CMS tracking systems have formed a collaborative ''Project on Enabling Technologies for Silicon Microstrip Tracking Detectors at the HL-LHC'' (PETTL), which was supported by the Helmholtz Alliance ''Physics at the Terascale'' during the years 2013 and 2014. The aim of the project was to share experience and to work together on key areas of mutual interest during the R and D phase of these upgrades. The project concentrated on five areas, namely exchange of experience, radiation hardness of silicon sensors, low mass system design, automated precision assembly procedures, and irradiations. This report summarizes the main achievements.

Enabling technologies for silicon microstrip tracking detectors at the HL-LHC

Energy Technology Data Exchange (ETDEWEB)

Feld, L.; Karpinski, W.; Klein, K. [RWTH Aachen Univ. (Germany). 1. Physikalisches Institut B; Collaboration: The PETTL Collaboration; and others

2016-04-15

While the tracking detectors of the ATLAS and CMS experiments have shown excellent performance in Run 1 of LHC data taking, and are expected to continue to do so during LHC operation at design luminosity, both experiments will have to exchange their tracking systems when the LHC is upgraded to the high-luminosity LHC (HL-LHC) around the year 2024. The new tracking systems need to operate in an environment in which both the hit densities and the radiation damage will be about an order of magnitude higher than today. In addition, the new trackers need to contribute to the first level trigger in order to maintain a high data-taking efficiency for the interesting processes. Novel detector technologies have to be developed to meet these very challenging goals. The German groups active in the upgrades of the ATLAS and CMS tracking systems have formed a collaborative ''Project on Enabling Technologies for Silicon Microstrip Tracking Detectors at the HL-LHC'' (PETTL), which was supported by the Helmholtz Alliance ''Physics at the Terascale'' during the years 2013 and 2014. The aim of the project was to share experience and to work together on key areas of mutual interest during the R and D phase of these upgrades. The project concentrated on five areas, namely exchange of experience, radiation hardness of silicon sensors, low mass system design, automated precision assembly procedures, and irradiations. This report summarizes the main achievements.

Role of (n, xn) reactions in ADS, IAEA-benchmark and the Dubna ...

Indian Academy of Sciences (India)

Dubna Cascade Code (version-2004) has been used for the Monte Carlo simulation of the 1500 MW accelerator driven sub-critical system (ADS) with 233U + 232Th fuel using the IAEA benchmark. Neutron spectrum, cross-section of (, ) reactions, isotopic yield, heat spectra etc. are simulated. Many of these results ...

Hairy AdS solitons

International Nuclear Information System (INIS)

Anabalón, Andrés; Astefanesei, Dumitru; Choque, David

2016-01-01

We construct exact hairy AdS soliton solutions in Einstein-dilaton gravity theory. We examine their thermodynamic properties and discuss the role of these solutions for the existence of first order phase transitions for hairy black holes. The negative energy density associated to hairy AdS solitons can be interpreted as the Casimir energy that is generated in the dual filed theory when the fermions are antiperiodic on the compact coordinate.

Hairy AdS solitons

Energy Technology Data Exchange (ETDEWEB)

Anabalón, Andrés, E-mail: andres.anabalon@uai.cl [Departamento de Ciencias, Facultad de Artes Liberales and Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez, Av. Padre Hurtado 750, Viña del Mar (Chile); Astefanesei, Dumitru, E-mail: dumitru.astefanesei@pucv.cl [Instituto de Física, Pontificia Universidad Católica de Valparaíso, Casilla 4059, Valparaíso (Chile); Choque, David, E-mail: brst1010123@gmail.com [Instituto de Física, Pontificia Universidad Católica de Valparaíso, Casilla 4059, Valparaíso (Chile); Universidad Técnica Federico Santa María, Av. España 1680, Valparaíso (Chile)

2016-11-10

We construct exact hairy AdS soliton solutions in Einstein-dilaton gravity theory. We examine their thermodynamic properties and discuss the role of these solutions for the existence of first order phase transitions for hairy black holes. The negative energy density associated to hairy AdS solitons can be interpreted as the Casimir energy that is generated in the dual filed theory when the fermions are antiperiodic on the compact coordinate.

Svět akademií. Rodina Jirečkova, Josef Hlávka a organizace české vědy (K 100. výročí úmrtí J. Hlávky)

Czech Academy of Sciences Publication Activity Database

Havlíková, Lubomíra

2008-01-01

Roč. 94, č. 4 (2008), s. 645-656 ISSN 0037-6922 Institutional research plan: CEZ:AV0Z90920516 Keywords : history of science * Hlávka, Josef (1831-1908) * Jireček, Hermenegild (1827-1909) * Jireček, Josef (1825-1888) * Jireček, Konstantin (1854-1918) * academy Subject RIV: AB - History

China Energy Databook -- User Guide and Documentation, Version 7.0

Energy Technology Data Exchange (ETDEWEB)

Fridley, Ed., David; Aden, Ed., Nathaniel; Lu, Ed., Hongyou; Zheng, Ed., Nina

2008-10-01

Since 2001, China's energy consumption has grown more quickly than expected by Chinese or international observers. This edition of the China Energy Databook traces the growth of the energy system through 2006. As with version six, the Databook covers a wide range of energy-related information, including resources and reserves, production, consumption, investment, equipment, prices, trade, environment, economy, and demographic data. These data provide an extensive quantitative foundation for understanding China's growing energy system. In addition to providing updated data through 2006, version seven includes revised energy and GDP data back to the 1990s. In the 2005 China Energy Statistical Yearbook, China's National Bureau of Statistics (NBS) published revised energy production, consumption, and usage data covering the years 1998 to 2003. Most of these revisions related to coal production and consumption, though natural gas data were also adjusted. In order to accommodate underestimated service sector growth, the NBS also released revised GDP data in 2005. Beyond the inclusion of historical revisions in the seventh edition, no attempt has been made to rectify known or suspected issues in the official data. The purpose of this volume is to provide a common basis for understanding China's energy system. In order to broaden understanding of China's energy system, the Databook includes information from industry yearbooks, periodicals, and government websites in addition to data published by NBS. Rather than discarding discontinued data series, information that is no longer possible to update has been placed in C section tables and figures in each chapter. As with previous versions, the data are presented in digital database and tabular formats. The compilation of updated data is the result of tireless work by Lu Hongyou and Nina Zheng.

Associative Memory Pattern Matching for the L1 Track Trigger of CMS at the HL-LHC

International Nuclear Information System (INIS)

Fedi, Giacomo

2016-01-01

The High Luminosity LHC (HL-LHC) will deliver a luminosity of up to 5 × 10 34 cm −2 s −1 , with an average of about 140 overlapping proton-proton collisions per bunch crossing. These extreme pileup conditions place stringent requirements on the trigger system to be able to cope with the resulting event rates. A key component of the CMS upgrade for HL-LHC is a track trigger system, able to identify tracks with transverse momenta above 2 GeV/c already at the first-level trigger. We present here the status of the implementation of a prototype system, based on the combination of Associative Memory custom ASIC and modern Field Programmable Gate Array (FPGA) devices, with the purpose to demonstrate the concept based on state-of-the-art technologies, and to direct the efforts of the necessary R&D toward a final system

VizieR Online Data Catalog: SKY2000 Master Catalog, Version 5 (Myers+ 2006)

Science.gov (United States)

Myers, J. R.; Sande, C. B.; Miller, A. C.; Warren, W. H., Jr.; Tracewell, D. A.

2015-02-01

The SKYMAP Star Catalog System consists of a Master Catalog stellar database and a collection of utility software designed to create and maintain the database and to generate derivative mission star catalogs (run catalogs). It contains an extensive compilation of information on almost 300000 stars brighter than 8.0mag. The original SKYMAP Master Catalog was generated in the early 1970's. Incremental updates and corrections were made over the following years but the first complete revision of the source data occurred with Version 4.0. This revision also produced a unique, consolidated source of astrometric information which can be used by the astronomical community. The derived quantities were removed and wideband and photometric data in the R (red) and I (infrared) systems were added. Version 4 of the SKY2000 Master Catalog was completed in April 2002; it marks the global replacement of the variability identifier and variability data fields. More details can be found in the description file sky2kv4.pdf. The SKY2000 Version 5 Revision 4 Master Catalog differs from Revision 3 in that MK and HD spectral types have been added from the Catalogue of Stellar Spectral Classifications (B. A. Skiff of Lowell Observatory, 2005), which has been assigned source code 50 in this process. 9622 entries now have MK types from this source, while 3976 entries have HD types from this source. SKY2000 V5 R4 also differs globally from preceding MC versions in that the Galactic coordinate computations performed by UPDATE have been increased in accuracy, so that differences from the same quantities from other sources are now typically in the last decimal places carried in the MC. This version supersedes the previous versions 1(V/95), 2(V/102), 3(V/105) and 4(V/109). (6 data files).

AdS solutions through transgression

International Nuclear Information System (INIS)

Donos, Aristomenis; Gauntlett, Jerome P.; Kim, Nakwoo

2008-01-01

We present new classes of explicit supersymmetric AdS 3 solutions of type IIB supergravity with non-vanishing five-form flux and AdS 2 solutions of D = 11 supergravity with electric four-form flux. The former are dual to two-dimensional SCFTs with (0,2) supersymmetry and the latter to supersymmetric quantum mechanics with two supercharges. We also investigate more general classes of AdS 3 solutions of type IIB supergravity and AdS 2 solutions of D = 11 supergravity which in addition have non-vanishing three-form flux and magnetic four-form flux, respectively. The construction of these more general solutions makes essential use of the Chern-Simons or 'transgression' terms in the Bianchi identity or the equation of motion of the field strengths in the supergravity theories. We construct infinite new classes of explicit examples and for some of the type IIB solutions determine the central charge of the dual SCFTs. The type IIB solutions with non-vanishing three-form flux that we construct include a two-torus, and after two T-dualities and an S-duality, we obtain new AdS 3 solutions with only the NS fields being non-trivial.

Applying a Particle-only Model to the HL Tau Disk

Science.gov (United States)

Tabeshian, Maryam; Wiegert, Paul A.

2018-04-01

Observations have revealed rich structures in protoplanetary disks, offering clues about their embedded planets. Due to the complexities introduced by the abundance of gas in these disks, modeling their structure in detail is computationally intensive, requiring complex hydrodynamic codes and substantial computing power. It would be advantageous if computationally simpler models could provide some preliminary information on these disks. Here we apply a particle-only model (that we developed for gas-poor debris disks) to the gas-rich disk, HL Tauri, to address the question of whether such simple models can inform the study of these systems. Assuming three potentially embedded planets, we match HL Tau’s radial profile fairly well and derive best-fit planetary masses and orbital radii (0.40, 0.02, 0.21 Jupiter masses for the planets orbiting a 0.55 M ⊙ star at 11.22, 29.67, 64.23 au). Our derived parameters are comparable to those estimated by others, except for the mass of the second planet. Our simulations also reproduce some narrower gaps seen in the ALMA image away from the orbits of the planets. The nature of these gaps is debated but, based on our simulations, we argue they could result from planet–disk interactions via mean-motion resonances, and need not contain planets. Our results suggest that a simple particle-only model can be used as a first step to understanding dynamical structures in gas disks, particularly those formed by planets, and determine some parameters of their hidden planets, serving as useful initial inputs to hydrodynamic models which are needed to investigate disk and planet properties more thoroughly.

HL-2A experiment and ITER-related activity at SWIP

International Nuclear Information System (INIS)

Duan Xuru

2007-01-01

In this overview the recent progress on HL-2A tokamak experiment and ITER-related activity at SWIP is summarized. Experiment on HL-2A is one of the important research activities at SWIP. In the last two years, some new hardware had been developed, these include four sets of ECRH system with a total power up to 2 MW, new diagnostics such as 8-channel laser interferometer. The studied subjects were focused on plasma auxiliary heating, fuelling, transport, edge plasma physics and turbulence, etc. Progress in these fields has been obtained. For example, the toroidal symmetry of the geodesic acoustic mode (GAM), the oscillating branch of zonal flows has been demonstrated for the first time using a novel 3-step Langmuir Probe, and the poloidal and radial structure of the low frequency electric potential and field were simultaneously observed. During ECRH experiments under different discharge conditions, the MHD instability excited by high energetic electrons was investigated. Besides, non-local heat transport due to SMBI during ECRH was studied. Another important fusion activity at SWIP is the ITER relevant technology. The R and D of four ITER procurements (first wall and shielding blanket, magnet gravity support, gas injection and glow discharge cleaning system, neutron flux measurement) has been undertaken. Progress has been made, e.g. the technology for manufacturing high purity (>99%) ITER specified Be plate and CuCrZr alloy is obtained, their major mechanical and physical properties were measured. For ITER-TBM, a structural material named as CLF-1, a type of reduced activation ferritic/martenstic steel, was developed. Besides, some progress in fusion reactor design and related technology was achieved. (authors)

Experiment study on the relationship between radiotherapy effect and 99Tcm-HL-91 and 18F-FDG imaging in S180 mouse

International Nuclear Information System (INIS)

Yang Aimin; Deng Huixing; Li Jie; Yu Yan; Li Xu; Chen Wei; Luo Wei

2010-01-01

To investigate the relationship between radiotherapy effect and 99 Tc m - HL-91 and 18 F-FDG imaging in S180 mouse. Methods: Animal: twenty male Kunming mice (27±3 g), obtained from animal center of medical school of Xi'an Jiaotong university, were randomly divided into two groups of radiotherapy and non-radiotherapy control group. Cells: S180 cell lines, obtained from molecular and biology center of medical school of Xi'an Jiaotong university, were thawed injected into peritoneal cavity of the 5 mouse. When the S180 tumor liquid developed, l ml liquid were dripped and dilute to the suspension solution of 2 × 106 cells. Then, 0.2 ml of it was injected into the hippo of right rear leg of mouse. The mouse model was used to experiment while the tumor dimension developed to 1-1.5 cm. 99 Tc m -HL-91 imaging: 37 MBq 99 Tc m -HL-91, obtained from Guangdong Xiai Radio-pharmaceutical Center, was injected into mouse models by tail vein. After for 4h, SPECT imaging were taken before and after radiotherapy at the time of 1 h, 2 d and 10 d. GE Hawkeye VG SPECT, equipped with low energy collimator, matrix 128 × 128, zoom 1.3, was used to acquire images for 150 seconds. Radiotherapy: Two groups mouse was irradiated to 0 Gy and 8 Gy X-ray after the first 99 Tc m -HL-91 and 18 F-FDG imaging. Images analysis: the ROI region, in tumor and lung site, was drawn for calculating the UR (uptake ratio). Results: After 1 h, 2 d and 10 d of radiation exposure, the UR values in 99 Tc m -HL-91 imaging were 3.53±1.62, 3.41±1.42, 2.5% 1.57 and 1.26±0.03, respectively, while the UR values were 3.62±1.65. 3.02±1.94, 4.10±1.48 and 2.96±2.02 in control group. This revealed that tumors hypoxic level was decreased after radiation and suggested that tumors develop re-oxygenation. After 11 d of radiation exposure, the UR values in 18 F-FDG imaging were 2.49±1.29 and 1.49±0.56, while the UR values were 2.22±0.45 and 1.89±0.08, expressing a coincident trend with 99 Tc m -HL-91 imaging. This

A new version of Scilab software package for the study of dynamical systems

Science.gov (United States)

Bordeianu, C. C.; Felea, D.; Beşliu, C.; Jipa, Al.; Grossu, I. V.

2009-11-01

ordinary differential equations for the study of chaotic flows. The chaotic behavior of the nonlinear dynamical system is analyzed using Poincare sections, phase-space maps, autocorrelation functions, power spectra, Lyapunov exponents and Kolmogorov-Sinai entropies. Numerical solving of iterative equations for the study of maps and fractals. Reasons for new version: The program has been updated to use the new version 5.1.1 of Scilab with new graphical capabilities [2]. Moreover, new use cases have been added which make the handling of the program easier and more efficient. Summary of revisions: A new use case concerning coupled predator-prey models has been added [3]. Three new use cases concerning fractals (Sierpinsky gasket, Barnsley's Fern and Tree) have been added [3]. The graphical user interface (GUI) of the program has been reconstructed to include the new use cases. The program has been updated to use Scilab 5.1.1 with the new graphical capabilities. Additional comments: The program package contains 12 subprograms. interface.sce - the graphical user interface (GUI) that permits the choice of a routine as follows 1.sci - Lorenz dynamical system 2.sci - Chua dynamical system 3.sci - Rosler dynamical system 4.sci - Henon map 5.sci - Lyapunov exponents for Lorenz dynamical system 6.sci - Lyapunov exponent for the logistic map 7.sci - Shannon entropy for the logistic map 8.sci - Coupled predator-prey model 1f.sci - Sierpinsky gasket 2f.sci - Barnsley's Fern 3f.sci - Barnsley's Tree Running time: 10 to 20 seconds for problems that do not involve Lyapunov exponents calculation; 60 to 1000 seconds for problems that involve high orders ODE, Lyapunov exponents calculation and fractals. References: C.C. Bordeianu, C. Besliu, Al. Jipa, D. Felea, I. V. Grossu, Comput. Phys. Comm. 178 (2008) 788. S. Campbell, J.P. Chancelier, R. Nikoukhah, Modeling and Simulation in Scilab/Scicos, Springer, 2006. R.H. Landau, M.J. Paez, C.C. Bordeianu, A Survey of Computational Physics

Strong versions of Bell's theorem

International Nuclear Information System (INIS)

Stapp, H.P.

1994-01-01

Technical aspects of a recently constructed strong version of Bell's theorem are discussed. The theorem assumes neither hidden variables nor factorization, and neither determinism nor counterfactual definiteness. It deals directly with logical connections. Hence its relationship with modal logic needs to be described. It is shown that the proof can be embedded in an orthodox modal logic, and hence its compatibility with modal logic assured, but that this embedding weakens the theorem by introducing as added assumptions the conventionalities of the particular modal logic that is adopted. This weakening is avoided in the recent proof by using directly the set-theoretic conditions entailed by the locality assumption

Silicon Strip Detectors for ATLAS at the HL-LHC Upgrade

CERN Document Server

Hara, K; The ATLAS collaboration

2012-01-01

present ATLAS silicon strip tracker (SCT) and transition radiation tracker(TRT) are to be replaced with new silicon strip detectors as part of the Inner Tracker System (ITK) for the Phase-II upgrade of the Large Hadron Collider, HL-LHC. We have carried out intensive R&D programs based on n+-on-p microstrip detectors to fabricate improved radiation hard strip detectors that can survive the radiation levels corresponding to the integrated luminosity of up to 3000 fb−1. We describe the main specifications for this year’s sensor fabrication and the related R&D results, followed by a description of the candidate schema for module integration.

[Validation of the Russian version of the modified Addenbrooke's cognitive examination for Alzheimer's disease diagnosis].

Science.gov (United States)

Levin, O S; Lavrov, A Yu; Lyashenko, Е А; Vasenina, E E; Trusova, N A; Datieva, V K; Makotrova, T A; Pilipenko, A Yu

2015-01-01

To evaluate the validity of the Russian version of the modified Addenbrooke's cognitive examination (ACE-m) for Alzheimer's disease (AD) diagnosis. ACE-m and MMSE, as a comparison scale, were administered to 78 patients including 49 patients with AD and 29 healthy people. ACE-m demonstrated the high validity in the diagnosis of dementia in AD. Cronbach's alpha was 0.89. ACE-m is a brief and simple in use test that measures a wide spectrum of cognitive functions, gives a general impression about cognitive deficit and diagnoses dementia in AD with the greater validity compared to MMSE. This scale is useful not only in diagnosis of AD but also in differentiation with other causes of dementia.

First observation of neoclassical tearing modes in the HL-2A tokamak

International Nuclear Information System (INIS)

Ji Xiaoquan; Yang Qingwei; Liu Yi; Zhou Jun; Feng Beibin; Yuan Baoshan

2010-01-01

The m/n=2/1 neoclassical tearing modes are first observed in HL-2A low density, low beta plasma with central electron cyclotron resonance heating. The neoclassical tearing modes (NTMs) are triggered by a sawtooth crash with m/n=1/1 precursors, which are toroidal coupled with a small scale m/n=2/1 mode. The time history of the island width is compared with the prediction of the NTM theory, showing a good agreement between theory and experiment. (authors)

Potential youth exposure to alcohol advertising on the internet: A study of internet versions of popular television programs.

Science.gov (United States)

Siegel, Michael; Kurland, Rachel P; Castrini, Marisa; Morse, Catherine; de Groot, Alexander; Retamozo, Cynthia; Roberts, Sarah P; Ross, Craig S; Jernigan, David H

No previous paper has examined alcohol advertising on the internet versions of television programs popular among underage youth. To assess the volume of alcohol advertising on web sites of television networks which stream television programs popular among youth. Multiple viewers analyzed the product advertising appearing on 12 television programs that are available in full episode format on the internet. During a baseline period of one week, six coders analyzed all 12 programs. For the nine programs that contained alcohol advertising, three underage coders (ages 10, 13, and 18) analyzed the programs to quantify the extent of that advertising over a four-week period. Alcohol advertisements are highly prevalent on these programs, with nine of the 12 shows carrying alcohol ads, and six programs averaging at least one alcohol ad per episode. There was no difference in alcohol ad exposure for underage and legal age viewers. There is a substantial potential for youth exposure to alcohol advertising on the internet through internet-based versions of television programs. The Federal Trade Commission should require alcohol companies to report the underage youth and adult audiences for internet versions of television programs on which they advertise.

Regulation of C/EBPβ isoforms by MAPK pathways in HL60 cells induced to differentiate by 1,25-dihydroxyvitamin D3

International Nuclear Information System (INIS)

Marcinkowska, Ewa; Garay, Edward; Gocek, Elzbieta; Chrobak, Agnieszka; Wang, Xuening; Studzinski, George P.

2006-01-01

C/EBPβ is known to be important for monocytic differentiation and macrophage function. Here, we found that expression of all three C/EBPβ isoforms induced in HL60 cells by 1,25-dihydroxyvitamin D 3 (1,25D) was upregulated in a sustained manner that correlates with the appearance of monocytic phenotype and with the G1 phase cell cycle arrest. In 1,25D-resistant HL60-40AF cells, isoforms β-1 and β-3 were expressed at levels comparable to 1,25D-sensitive HL60-G cells, but isoform β-2 was difficult to detect. Treatment of sensitive HL60 cells with 1,25D resulted in predominantly nuclear localization of C/EBP isoforms β-2 and β-3, while a large proportion of C/EBPβ-1 remained in the cytoplasm. Attenuation of the MEK-ERK MAPK pathway by the inhibitor PD98059 markedly reduced the expression, 1,25D-induced phosphorylation and nuclear localization of C/EBPβ-2 and C/EBPβ-3. Interestingly, only the lower molecular mass isoforms of C/EBPβ phosphorylated on Thr235 were found in the nuclei, while C/EBPβ-1 was constitutively phosphorylated and was detected principally in the cytoplasmic fraction. Although the role of C/EBPβ isoforms in 1,25D-induced differentiation is complex, our results taken together strongly suggest that the phosphorylation of C/EBPβ isoforms on Thr235 takes place mainly via the MEK-ERK pathway and that C/EBPβ-2 is the principal transcription factor in this cell system

Impact of mobility on the performance of relaying in ad hoc networks (Extended version)

NARCIS (Netherlands)

Al Hanbali, A.; Kherani, A.A.; Groenevelt, R.; Nain, P.; Altman, E.

2007-01-01

We consider a mobile ad hoc network consisting of three types of nodes: source, destination, and relay nodes. All the nodes are moving over a bounded region with possibly different mobility patterns. We introduce and study the notion of relay throughput, i.e. the maximum rate at which a node can

Involvement of Src tyrosine kinase and protein kinase C in the expression of macrophage migration inhibitory factor induced by H{sub 2}O{sub 2} in HL-1 mouse cardiac muscle cells

Energy Technology Data Exchange (ETDEWEB)

Rao, F. [Department of Cardiology, Guangdong General Hospital, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou (China); Research Center of Medical Sciences, Guangdong General Hospital, Guangzhou (China); Guangdong Academy of Medical Sciences, Guangzhou (China); Deng, C.Y. [Research Center of Medical Sciences, Guangdong General Hospital, Guangzhou (China); Guangdong Academy of Medical Sciences, Guangzhou (China); Zhang, Q.H.; Xue, Y.M. [Department of Cardiology, Guangdong General Hospital, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou (China); Guangdong Academy of Medical Sciences, Guangzhou (China); Xiao, D.Z.; Kuang, S.J.; Lin, Q.X.; Shan, Z.X.; Liu, X.Y.; Zhu, J.N. [Research Center of Medical Sciences, Guangdong General Hospital, Guangzhou (China); Guangdong Academy of Medical Sciences, Guangzhou (China); Yu, X.Y. [Department of Cardiology, Guangdong General Hospital, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou (China); Research Center of Medical Sciences, Guangdong General Hospital, Guangzhou (China); Guangdong Academy of Medical Sciences, Guangzhou (China); Wu, S.L. [Department of Cardiology, Guangdong General Hospital, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou (China); Guangdong Academy of Medical Sciences, Guangzhou (China)

2013-09-06

Macrophage migration inhibitory factor (MIF), a pleiotropic cytokine, plays an important role in the pathogenesis of atrial fibrillation; however, the upstream regulation of MIF in atrial myocytes remains unclear. In the present study, we investigated whether and how MIF is regulated in response to the renin-angiotensin system and oxidative stress in atrium myocytes (HL-1 cells). MIF protein and mRNA levels in HL-1 cells were assayed using immunofluorescence, real-time PCR, and Western blot. The result indicated that MIF was expressed in the cytoplasm of HL-1 cells. Hydrogen peroxide (H{sub 2}O{sub 2}), but not angiotensin II, stimulated MIF expression in HL-1 cells. H{sub 2}O{sub 2}-induced MIF protein and gene levels increased in a dose-dependent manner and were completely abolished in the presence of catalase. H{sub 2}O{sub 2}-induced MIF production was completely inhibited by tyrosine kinase inhibitors genistein and PP1, as well as by protein kinase C (PKC) inhibitor GF109203X, suggesting that redox-sensitive MIF production is mediated through tyrosine kinase and PKC-dependent mechanisms in HL-1 cells. These results suggest that MIF is upregulated by HL-1 cells in response to redox stress, probably by the activation of Src and PKC.

Virtual Compton Scattering off a Spinless Target in the AdS/QCD correspondence

CERN Document Server

Marquet, C.; Wallon, S.

2010-01-01

We perform a study of the doubly virtual Compton scattering off a spinless target gamma* P -> gamma* P' within the Anti-de Sitter(AdS)/QCD formalism. We find that the general structure allowed by the Lorentz invariance and gauge invariance of the Compton amplitude is not easily reproduced with the standard recipes of the AdS/QCD correspondence. In the soft-photon regime, where the semi-classical approximation is supposed to apply best, we show that the measurements of the electric and magnetic polarizabilities of a target like the charged pion in real Compton scattering, can already serve as stringent tests, and presumably exclude results based on the AdS/QCD correspondence in its minimal version.

Decay constants in soft wall AdS/QCD revisited

Energy Technology Data Exchange (ETDEWEB)

Braga, Nelson R.F., E-mail: braga@if.ufrj.br [Instituto de Física, Universidade Federal do Rio de Janeiro, Caixa Postal 68528, RJ 21941-972 (Brazil); Diles, Saulo, E-mail: smdiles@if.ufrj.br [Instituto de Física, Universidade Federal do Rio de Janeiro, Caixa Postal 68528, RJ 21941-972 (Brazil); Contreras, M.A. Martin, E-mail: ma.martin41@uniandes.edu.co [High Energy Group, Department of Physics, Universidad de los Andes, Carrera 1, No 18A-10, Bloque Ip, ZIP 111711, Bogotá (Colombia)

2016-12-10

Phenomenological AdS/QCD models, like hard wall and soft wall, provide hadronic mass spectra in reasonable consistency with experimental and (or) lattice results. These simple models are inspired in the AdS/CFT correspondence and assume that gauge/gravity duality holds in a scenario where conformal invariance is broken through the introduction of an energy scale. Another important property of hadrons: the decay constant, can also be obtained from these models. However, a consistent formulation of an AdS/QCD model that reproduces the observed behavior of decay constants of vector meson excited states is still lacking. In particular: for radially excited states of heavy vector mesons, the experimental data lead to decay constants that decrease with the radial excitation level. We show here that a modified framework of soft wall AdS/QCD involving an additional dimensionfull parameter, associated with an ultraviolet energy scale, provides decay constants decreasing with radial excitation level. In this version of the soft wall model the two point function of gauge theory operators is calculated at a finite position of the anti-de Sitter space radial coordinate.

WIMS-IJSO - An extended version of the WIMS group constant library

International Nuclear Information System (INIS)

Trkov, A.; Perdan, A.

1982-11-01

WIMS-IJSO is a preliminary extended version of the WIMS library as supplied with the CDC version of the S-WIMS-code. It is a result of the feasibility study of the possibility to update and extend the WIMS library. In the course of its preparation valuable experience was gained in understanding the definitions, the conventions and the structure of the WIMS library. This experience will be used in the preparation of an extended WIMS library for some materials from carefully chosen evaluated data. The library as supplied with the WIMS-D4 package will be used as the basis. The materials added to the library had been tested in reactor calculations and their performance was found to be satisfactory. The aim of releasing the preliminary version of the WIMS library is to allow different users to apply the data to various problems

The (7,7) optics at CERN PS

CERN Document Server

Serluca, M; Efthymiopoulos, I; Sperati, F; Sterbini, G; Tecker, F; Zisopoulos, P

2017-01-01

The PS lattice is composed by one hundred combinedfunction magnets, which set the bare tune of the machineto (Qh,Qv) = (6.25, 6.28). Low energy quadrupoles areused at injection to move the tune in a limited working pointarea. In particular the vertical tune is moved below 6.25 toavoid the structural resonance 8Qv= 50 coupled with spacecharge, which leads to strong losses. In view of the highdemands in terms of beam brightness for LIU and HL-LHCprojects, the interest of exploring different integer tune work-ing area started during last years. During 2016, for the firsttime, it has been possible to explore the (7,7) tune workingarea at injection using the auxiliary circuits of the combinedfunction magnets. A finite-element magnetic model, underdevelopment, has been used to predict the required currentsin order to get the desired optical parameters. In this pa-per we present the results and issues encountered duringthe Machine Development (MD) studies about the injectionin the (7,7) area along with optics and be...

1799-1999 Bicentenario dell'invenzione della Pila ad opera di Alessandro Volta - Evoluzione del sito

OpenAIRE

Montalbetti, Claudia

1998-01-01

In questo articolo sono riportate le modifiche apportate al sito Volta99, sito ufficiale delle celebrazioni per il bicentenario dell'invenzione della pila ad opera di Alessandro Volta. Indirizzo: http://www.cilea.it/volta99. Rispetto alla versione illustrata sul bollettino n.62 sono state introdotte due importanti novità: la versione italiana e la bibliografia delle fonti secondarie. Per questa modifica è risultato molto utile per la gestione e la velocità di inserimento la scelta fatta di ut...

A new Highly Selective First Level ATLAS Muon Trigger With MDT Chamber Data for HL-LHC

CERN Document Server

Nowak, Sebastian; The ATLAS collaboration

2015-01-01

Highly selective first level triggers are essential for the physics programme of the ATLAS experiment at the HL-LHC where the instantaneous luminosity will exceed the LHC's instantaneous luminosity by almost an order of magnitude. The ATLAS first level muon trigger rate is dominated by low momentum sub-trigger threshold muons due to the poor momentum resolution at trigger level caused by the moderate spatial resolution of the resistive plate and thin gap trigger chambers. This limitation can be overcome by including the data of the precision muon drift tube chambers in the first level trigger decision. This requires the implementation of a fast MDT read-out chain and a fast MDT track reconstruction. A hardware demonstrator of the fast read-out chain was successfully tested under HL-LHC operating conditions at CERN's Gamma Irradiation Facility. It could be shown that the data provided by the demonstrator can be processed with a fast track reconstruction algorithm on an ARM CPU within the 6 microseconds latency...

High performance experiments on high pressure supersonic molecular beam injection in the HL-1M tokamak

International Nuclear Information System (INIS)

Yao Lianghua; Dong Jiafu; Zhou Yan; Feng Beibing; Cao Jianyong; Li Wei; Feng Zhen; Zhang Jiquan; Hong Wenyu; Cui Zhengying; Wang Enyao; Liu Yong

2004-01-01

Supersonic molecular beam injection (SMBI) was first proposed and demonstrated on the HL-1 tokamak and was successfully developed and used on HL-1M. Recently, new results of SMBI experiments were obtained by increasing the gas pressure from 0.5 to over 1.0 MPa. A stair-shaped density increment was obtained with high-pressure multi-pulse SMBI that was similar to the density evolution behaviour during multi-pellet injection. This demonstrated the effectiveness of SMBI as a promising fuelling tool for steady-state operation. The penetration depth and injection speed of the high-pressure SMBI were roughly measured from the contour plot of the Hα emission intensity. It was shown that injected particles could penetrate into the core region of the plasma. The penetration speed of high-pressure SMBI particles in the plasma was estimated to be about 1200 m s -1 . In addition, clusters within the beam may play an important role in the deeper injection. (author)

Transfer and development of the PC version of ABAQUS program

International Nuclear Information System (INIS)

Li Xiaofeng; Zhu Yuqiao

1998-01-01

The transfer and development of the PC version of ABAQUS,a large nonlinear mechanical finite element analysis program, are carried out. Some special problem such as difference of the floating data format in different computers and the computer's unusual dead halt during the data transfer is solved and the visualized I/O capability is added in the redevelopment. Thus, by utilizing the visual capability, the intensity of analysis works is reduced, and the correctness of analysis is ensured. The PC ABAQUS are tested by the standard examples from VAX version of ABAQUS and the calculation results are correct. The results of calculation of stress and deformation for CEFR shell structure with PC ABAQUS and ADINA codes agree very well

Confinement near Argyres-Douglas point in N=2 QCD and low energy version of AdS/CFT correspondence

International Nuclear Information System (INIS)

Yung, Alexei

2002-01-01

We study Abrikosov-Nielsen-Olesen (ANO) flux tubes on the Higgs branch of N=2 QCD with SU(2) gauge group and N f =2 flavors of fundamental matter. In particular, we consider this theory near Argyres-Douglas (AD) point where the mass of monopoles connected by these ANO strings become small. In this regime the effective QED which describes the theory on the Higgs branch becomes strongly coupled. We argue that the appropriate description of the theory is in terms of long and thin flux tubes (strings) with small tension. We interpret this as another example of duality between field theory in strong coupling and string theory in weak coupling. Then we consider the non-critical string theory for these flux tubes which includes fifth (Liouville) dimension. We identify CFT at the AD point as UV fix point corresponding to AdS metric on the 5d 'gravity' side. The perturbation associated with the monopole mass term creates a kink separating UV and IR behavior. We estimate the renormalized string tension and show that it is determined by the small monopole mass. In particular, it goes to zero at the AD point

Developing an integrated electronic nursing record based on standards.

Science.gov (United States)

van Grunsven, Arno; Bindels, Rianne; Coenen, Chel; de Bel, Ernst

2006-01-01

The Radboud University Nijmegen Medical Centre in the Netherlands develops a multidisciplinar (Electronic Health Record) based on the latest HL7 v3 (Health Level 7 version 3) D-MIM : Care provision. As part of this process we are trying to establish which nursing diagnoses and activities are minimally required. These NMDS (Nursing Minimal Data Set) are mapped or translated to ICF (for diagnoses) and CEN1828 Structures for (for activities). The mappings will be the foundation for the development of user interfaces for the registration of nursing activities. A homegrown custom-made web based configuration tool is used to exploit the possibilities of HL7 v3. This enables a sparkling launch of user interfaces that can contain the diversity of health care work processes. The first screens will be developed to support history taking for the nursing chart of the Neurology ward. The screens will contain both Dutch NMDS items and ward specific information. This will be configured dynamically per (group of) ward(s).