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Sample records for added punica granatum

  1. Punica granatum

    Science.gov (United States)

    Aparecida Procópio Gomes, Livia; Alves Figueiredo, Lívia Mara; Luiza do Rosário Palma, Ana; Corrêa Geraldo, Barbara Maria; Isler Castro, Kelly Cristine; Ruano de Oliveira Fugisaki, Luciana; Jorge, Antônio Olavo Cardoso; de Oliveira, Luciane Dias; Junqueira, Juliana Campos

    2016-01-01

    Due to the increase of bacterial resistance, medicinal alternatives are being explored. Punica granatum L. is an effective herbal extract with broad spectrum of action and bactericidal, antifungal, anthelmintic potential and being able to modulate the immune response. The aim was to evaluate the antimicrobial activity of pomegranate glycolic extract (PGE) against the periodontal pathogen Porphyromonas gingivalis by using Galleria mellonella as in vivo model. Fifteen larvae were used per group. Injection of high concentration (200, 100, and 25 mg/mL) of PGE showed a toxic effect, leading them to death. A suspension of P. gingivalis (10 6 cells/mL) was inoculated in the left last proleg and PGE (12.5, 6.25, 3.1, and 2.5 mg/mL) were injected into the right proleg. The larvae were then kept at 37°C under the dark. Injection of PGE at any dose statistically improved larvae survival rates. The data were analysed (log-rank test, Mantel-Cox, P < 0.05) and showed that all concentrations of PGE (12.5, 6.25, 3.1, and 2.5 mg/mL) presented higher larval survival rates, with significant statistical difference in relation to control group ( P. gingivalis ). In conclusion, the PGE had antimicrobial action against P. gingivalis in vivo model using G. mellonella .

  2. Micropropagation of pomegranate ( Punica granatum L.) 'Bhagava ...

    African Journals Online (AJOL)

    Reliable and reproducible protocols to get healthy and well formed plants from nodal explants of the pomegranate (Punica granatum L) cv 'Bhagava' has been developed. Nodal segments were cultured on two different media at full strength Murashige and Skoog (MS) and Woody Plant Medium (WPM). The media was ...

  3. Antimicrobial Ellagitannin of Punica granatum Fruits

    Directory of Open Access Journals (Sweden)

    Machado Thelma de B.

    2002-01-01

    Full Text Available The ethyl acetate extract of Punica granatum fruits was fractionated by chromatographic techniques to afford the ellagitannin punicalagin. The substance was found to be active against methicillin-resistant Staphylococcus aureus strains and was identified by HPLC/UV and ¹HNMR. The antibacterial assays which guided the isolation of the tannin were conducted using the disc diffusion method. Minimum inhibitory concentration (MIC was determined by the dilution method according to NCCLS (National Committee for Clinical Laboratory Standards procedure.

  4. Monoacylglycerol from Punica granatum seed oil.

    Science.gov (United States)

    Fatope, Majekodunmi O; Al Burtomani, Suad Khamis S; Takeda, Yoshio

    2002-01-16

    The seeds of Punica granatum, known as hap roman in the Arabian Peninsula, are commonly eaten as a dessert. As part of an ongoing project to find nonnutritional natural products which have health benefits, or that can be exploited to protect crops, the chloroform-soluble extract of the fermented seeds of P. granatum was found to be rich in 1-O-trans,cis,trans-9,11,13-octadecatrienoyl glycerol (1). The seed oil is not lethal to brine shrimp larvae. 1-O-isopentyl-3-O-octadec-2-enoyl glycerol (2) and the known cis-9-octadecenoic, octadecanoic, and eicosanoic acids were also detected in small amounts in the seed oil by LC and MS. The structure of 1 was determined from NMR and MS spectral data.

  5. Anti-urolithiatic effects of Punica granatum in male rats.

    Science.gov (United States)

    Rathod, N R; Biswas, Dipak; Chitme, H R; Ratna, Sanjeev; Muchandi, I S; Chandra, Ramesh

    2012-03-27

    The traditional use of Punica granatum has been reported to regulate urine discharge and controls the burning sensation of urine. Animals model of calcium oxalate urolithiasis was developed in male rats by adding ethylene glycol 0.75% in drinking water. The Punica granatum chloroform extract (PGCE) and Punica grantum methanol extract (PGME) orally at 100, 200 and 400mg/kg, respectively, were administered along with ethylene glycol for 28 days. On 28 day, 24h urine was collected from individual rats and used for estimation of urine calcium, phosphate and oxalate. The serum creatinine, urea and uric acid levels were estimated in each animal. The kidney homogenate was used for the estimation of renal oxalate contents. The paraffin kidney sections were prepared to observe the CaOx deposits. The ethylene glycol control (Gr.-II) had significant (P400mg/kg doses, significantly (P400mg/kg, found to be more effective in decreasing the urolithiasis and regeneration of renal tissues in male rats. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  6. Therapeutic applications of pomegranate (Punica granatum L.): a review

    National Research Council Canada - National Science Library

    Jurenka, Julie S

    2008-01-01

    The pomegranate, Punica granatum L., is an ancient, mystical, unique fruit borne on a small, long-living tree cultivated throughout the Mediterranean region, as far north as the Himalayas, in Southeast Asia, and in California...

  7. Determination of Bioactive Components of Ethyl Acetate Fraction of Punica granatum Rind Extract

    OpenAIRE

    J. Sangeetha; K. Vijayalakshmi

    2011-01-01

    Punica granatum belongs to a Punicaceae family. The Punica granatum is valued as a powerful medicinal plant and used in folk medicines. Hence the present investigation was carried out to determine the possible chemical components from ethyl acetate fraction of Punica granatum rind extract by GC-MS Technique. This analysis revealed that ethyl acetate fraction of Punica granatum rind extract contain Pyrogallol (41.88%), 5-Hydroxymethylfurfural (14.10%), D-Allose (9.17%), 2-Methoxy-1, 4-Benzened...

  8. A Review Study on Punica granatum L.

    Science.gov (United States)

    Shaygannia, Erfaneh; Bahmani, Mahmoud; Zamanzad, Behnam; Rafieian-Kopaei, Mahmoud

    2016-07-01

    Punica granatum L (pomegranate) is a deciduous shrub, native to Iran. Nowadays, besides its use as a fruit, its medicinal properties have attracted the interest of researchers of many countries. Pomegranate fruit has medicinal properties such as anti-inflammatory and antibacterial activities. The pomegranate seed oil has inhibitory effect on skin and breast cancers. The pomegranate seed oil has phytoestrogenic compounds and the fruit is rich in phenolic compounds with strong antioxidant activity. Ellagic acid is one of the main components of pomegranate with phenolic structure and antioxidant activity. This review article presents the recently published findings on different aspects of this plant focusing on its medicinal properties. © The Author(s) 2015.

  9. Anti-Ulcerative Potential of Punica granatum L (Lythraceae ...

    African Journals Online (AJOL)

    Purpose: To evaluate the antiulcer activities of the methanol extract of pomegranate (Punica granatum L) fruit peel using 80 % ethanol-induced gastric ulcer model in rats. Methods: Male Wistar rats, 175 - 220 g, were fasted for 48 h, but had free access to water. They were randomly divided into nine experimental groups.

  10. Punica granatum: A New Host of Bipolaris spicifera in Morocco

    Directory of Open Access Journals (Sweden)

    Oumama Kadri

    2011-01-01

    Full Text Available During March 2009 in the public gardens and the University of Sciences of Kenitra city (Morocco, 60% of leaves of 100 plants of pomegranate (Punica granatum L. ’Nana’ presented foliar lesions that affecting the aesthetic appearance of this ornamental plant. Bipolaris spicifera was isolated from ten necrotic lesions of 25 leaves. The artificial inoculation of the healthy leaves of three plants of Punica granatum L. ’Nana’ by conidial suspension of the pathogen induced the same lesions to that observed in nature. The diseased foliar surface and the total number of diseased leaves 30 days after inoculation with B. spicifera conidial suspension were 37.5% and 78. Conidia production of B. spicifera on inoculated leaves was 0.81 x 105 spore cm-2 and the fungus was re-isolated from lesions on inoculated plants. This is the first report of B. spicifera on pomegranate in Morocco.

  11. Ultrasound assisted extraction of polyphenols from Punica granatum (Grenada fruit

    Directory of Open Access Journals (Sweden)

    Jorge Enrique Rodríguez Chanfrau

    Full Text Available Introduction: extraction of bioactive compounds from vegetable materials is a classical operation applied in many industrial processes. Few studies have made reference to processes to obtain extracts from Punica granatum. This fruit is generally consumed as such or as fermented juices. In Cuba, it is known as grenade and numerous studies have shown antiviral, antioxidant and antimicrobial properties. Maceration process is the main used technology in the preparation of extracts from Punica granatum fruit, being this a long and expensive process. Ultrasound-assisted extractions have been proven to significantly decreased extraction time and increased extraction yields in many vegetable materials. However, few papers report the use of this methodology in the extraction processes of Punica granatum. Objective: to evaluate an ultrasound-assisted extraction process to extract polyphenols from Punica granatum fruit. Methods: an experimental surface, response 3², randomized and replicate design was made to identify the effect of the extraction time and the alcoholic concentration of the menstruum as well as an extraction study in the course of time, keeping the best extraction conditions set in the design. Results: the studied parameters did not show significant influence over the process (p= 0.0981 and p= 0.8504 for time of extraction and alcoholic content, respectively. The behaviour curve of the polyphenol extraction in time showed that top concentration values were reached at 60 minutes. Conclusions: according to results, the optimal conditions of polyphenol extraction were as follows: extraction time of 60 min, and 50 % alcoholic concentration (v/v as menstruum.

  12. Multiple Activities of Punica granatum Linne against Acne Vulgaris

    OpenAIRE

    Chia-Jung Lee; Lih-Geeng Chen; Wen-Li Liang; Ching-Chiung Wang

    2017-01-01

    Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. In this study, we found that pomegranate extract (PG-E) significantly reduced P. acnes-induced edema in Wistar rat ears. Therefore, an evaluation platform using multiple pathogenic mechanis...

  13. Growth-Inhibitory and Apoptosis-Inducing Effects of Punica granatum L. var. spinosa (Apple Punice) on Fibrosarcoma Cell Lines

    OpenAIRE

    Sineh Sepehr, Koushan; Baradaran, Behzad; Mazandarani, Masoumeh; Yousefi, Bahman; Abdollahpour Alitappeh, Meghdad; Khori, Vahid

    2014-01-01

    Purpose: Punica granatum L. var. granatum (Pomegranate), an herbaceous plant found in Iran, The aim of this study was to investigate the cytotoxic effects, induction of apoptosis, and the mechanism of cell death of ethanol extract from Punica granatum L. var. spinosa on the mouse fibrosarcoma cell line, WEHI-164.

  14. Studies on antidiarrhoeal activity of Punica granatum seed extract in rats.

    Science.gov (United States)

    Das, A K; Mandal, S C; Banerjee, S K; Sinha, S; Das, J; Saha, B P; Pal, M

    1999-12-15

    Methanol extract of Punica granatum seed was evaluated for antidiarrhoeal activity against different experimental models of diarrhoea in rats. P. granatum seed extract treated animals showed significant inhibitory activity against castrol-oil induced diarrhoea and PGE2 induced enteropooling in rats. The extract also showed a significant reduction in gastro-intestinal motility in charcoal meal test in rats. The results obtained established the efficacy of P. granatum seed extract as an antidiarrhoeal agent.

  15. Antibacterial Effect of Hydroalcoholic Extract of Punica granatum Linn. Petal on Common Oral Microorganisms

    OpenAIRE

    Farnaz Hajifattahi; Elham Moravej-Salehi; Maryam Taheri; Arash Mahboubi; Mohammad Kamalinejad

    2016-01-01

    Objectives. This study aimed to assess the effect of hydroalcoholic extract of Punica granatum Linn. (P. granatum) petal on Streptococcus sanguinis, Streptococcus mutans, Streptococcus salivarius, Streptococcus sobrinus, and Enterococcus faecalis. Materials and Methods. In this in vitro study, P. granatum extract was prepared using powdered petals and water-ethanol solvent. Antibacterial effect of the extract, chlorhexidine (CHX), and ampicillin was evaluated on brain heart infusion agar (BHI...

  16. Pomegranate (Punica granatum L.) response to different deficit irrigation conditions

    OpenAIRE

    Galindo Egea, Alejandro

    2015-01-01

    [ESP] El trabajo se centró en el estudio de algunos aspectos agronómicos y fisiológicos de la respuesta del granado (Punica granatum) a diferentes condiciones de riego. A este fin se abordaron i) los mecanismos desarrollados a nivel de fruto y hoja para afrontar situaciones de déficit hídrico, ii) la comparación de distintos indicadores del déficit hídrico y iii) el estudio del efecto de las condiciones de riego deficitario y la maduración sobre las características físicas y químicas de la gr...

  17. A comparative evaluation of efficacy of Punica granatum and chlorhexidine on plaque and gingivitis

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    Sakshi Ahuja

    2011-01-01

    Full Text Available Background: Periodontal diseases are chronic bacterial infections that lead to gingival inflammation, periodontal tissue destruction, and alveolar bone loss. Acting as powerful allies in the fight against periodontal disease, natural compounds can help safeguard against lethal age-related diseases that emanate from our mouths. Punica granatum (pomegranate shrub belongs to the Punicaceae family which has been used as an astringent, hemostatic, antidiabetic, antihelmintic, and also for diarrhea and dysentery. The aim of the present work was to investigate the possible efficacy of hydroalcoholic extract from Punica granatum fruit as an antiplaque and antigingivitis agent when compared with chlorhexidine. Materials and Methods: Twenty subjects diagnosed with chronic generalized gingivitis were selected and randomly divided into two groups: Group 1 - Pomegranate mouthwash and Group 2 - Chlorhexidine mouthwash. Punica granatum mouthwash was prepared using raw Punica granatum fruit. Patients were instructed to use the prescribed mouthwash for 15 days. Clinical evaluation was undertaken using the gingival index, the plaque index, and bleeding on probing at baseline, 7 days, and 15 days. Results: The clinical study observed significant improvement in gingival status in both the sites (P<0.05. Subjects using Punica granatum mouthwash showed significant improvement in bleeding and gingivitis score as compared with chlorhexidine. In contrast, Punica granatum was shown not to be so effective in reducing plaque scores. Chlorhexidine still remains as a standard in the reduction of plaque in subjects with gingivitis. Conclusion: Punica granatum mouthwash is beneficial in improving gingival status due to its profound styptic action, with sufficient reduction in plaque scores.

  18. Punica granatum L. Çekirdek ve Kabuk Ekstrelerinin Antioksidan Aktiviteleri

    OpenAIRE

    DEMİR, Hülya

    2008-01-01

    Bu çalışmada, Punica granatum L.(Punicaceae) "Nar", meyve çekirdeği ile kabuk ekstraklarının antioksidan aktiviteleri araştırıldı. Punica granatum L. çekirdek ve kabuğunun metanol ve hekzan ekstrelerinde serbest radikal giderme aktivite, indirgenme gücü analizleri yapıldı. Elde edilen sonuçlar standart antioksidan olarak bilinen askorbik asit ile karşılaştırıldı. Bu çalışmada elde edilen sonuçlara göre antioksidan aktivite Askorbik asit> Punica granatum L. kabuğu> Puni...

  19. Multiple Activities of Punica granatum Linne against Acne Vulgaris

    Directory of Open Access Journals (Sweden)

    Chia-Jung Lee

    2017-01-01

    Full Text Available Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. In this study, we found that pomegranate extract (PG-E significantly reduced P. acnes-induced edema in Wistar rat ears. Therefore, an evaluation platform using multiple pathogenic mechanisms of acne was established to explore the anti-acne effects of pomegranate. Results showed that PG-E inhibited bacterial growth and lipase activity. Through a bioguided-fractionation-isolation system, four hydrolysable tannins, punicalagin (1, punicalin (2, strictinin A (3, and granatin B (4, were isolated. Compounds 1 and 2 had greater anti-bacterial activities and anti-testosterone-induced HaCaT proliferative effects than the others. Compounds 1, 3, and 4 displayed lipase inhibitory effects. Compound 4 decreased cyclooxygenase-2 expression and downregulated prostaglandin E2 production in heat-killed P. acnes-treated RAW 246.7 cells. In conclusion, PG-E is abundant in hydrolysable tannins that display multiple anti-acne capacities, including anti-bacterial, anti-lipase, anti-keratinocyte proliferation, and anti-inflammatory actions. Hence, PG-E has great potential in the application of anti-acne and skin-care products, and punicalagin (1, the most effective component in PG-E, can be employed as a quality control marker.

  20. Multiple Activities of Punica granatum Linne against Acne Vulgaris

    Science.gov (United States)

    Lee, Chia-Jung; Chen, Lih-Geeng; Liang, Wen-Li; Wang, Ching-Chiung

    2017-01-01

    Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. In this study, we found that pomegranate extract (PG-E) significantly reduced P. acnes-induced edema in Wistar rat ears. Therefore, an evaluation platform using multiple pathogenic mechanisms of acne was established to explore the anti-acne effects of pomegranate. Results showed that PG-E inhibited bacterial growth and lipase activity. Through a bioguided-fractionation-isolation system, four hydrolysable tannins, punicalagin (1), punicalin (2), strictinin A (3), and granatin B (4), were isolated. Compounds 1 and 2 had greater anti-bacterial activities and anti-testosterone-induced HaCaT proliferative effects than the others. Compounds 1, 3, and 4 displayed lipase inhibitory effects. Compound 4 decreased cyclooxygenase-2 expression and downregulated prostaglandin E2 production in heat-killed P. acnes-treated RAW 246.7 cells. In conclusion, PG-E is abundant in hydrolysable tannins that display multiple anti-acne capacities, including anti-bacterial, anti-lipase, anti-keratinocyte proliferation, and anti-inflammatory actions. Hence, PG-E has great potential in the application of anti-acne and skin-care products, and punicalagin (1), the most effective component in PG-E, can be employed as a quality control marker. PMID:28085116

  1. Anticancer Activity of Punica granatum (Pomegranate): A Review.

    Science.gov (United States)

    Panth, Nisha; Manandhar, Bikash; Paudel, Keshav Raj

    2017-04-01

    Cancer is a pathological condition where excessive and abnormal cell growth leads to widespread invasion within the body to affect various organ functions. It is known that chemotherapeutic agents are themselves possible candidate of cancer generation as they can kill normal cells. So, therapeutic approach for cancer treatment and prevention is weighed in terms of benefit to risk ratio. Nowadays, there is an immense interest for the search herbal formulation with cancer preventive effect because of the problems, generated with existing chemotherapeutic regimens. Research interest in fruits rich in polyphenols is increasing because of their anticancer potential. In this review, we highlight the potential health benefits of pomegranate (Punica granatum) fruit and the underlying mechanism of its inhibition of cancer progression. Pomegranate has demonstrated anti-proliferative, anti-metastatic and anti-invasive effects on various cancer cell line in vitro as well as in vivo animal model or human clinical trial. Although several clinical trials are in progress for identifying the pomegranate as a candidate for various cancer treatment. It is necessary to replicate and validate its therapeutic efficacy by multiple clinical studies in order to formulate pomegranate products as an integral part of the dietary and pharmacological intervention in anticancer therapy. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  2. Multiple Activities of Punica granatum Linne against Acne Vulgaris.

    Science.gov (United States)

    Lee, Chia-Jung; Chen, Lih-Geeng; Liang, Wen-Li; Wang, Ching-Chiung

    2017-01-12

    Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. In this study, we found that pomegranate extract (PG-E) significantly reduced P. acnes-induced edema in Wistar rat ears. Therefore, an evaluation platform using multiple pathogenic mechanisms of acne was established to explore the anti-acne effects of pomegranate. Results showed that PG-E inhibited bacterial growth and lipase activity. Through a bioguided-fractionation-isolation system, four hydrolysable tannins, punicalagin (1), punicalin (2), strictinin A (3), and granatin B (4), were isolated. Compounds 1 and 2 had greater anti-bacterial activities and anti-testosterone-induced HaCaT proliferative effects than the others. Compounds 1, 3, and 4 displayed lipase inhibitory effects. Compound 4 decreased cyclooxygenase-2 expression and downregulated prostaglandin E₂ production in heat-killed P. acnes-treated RAW 246.7 cells. In conclusion, PG-E is abundant in hydrolysable tannins that display multiple anti-acne capacities, including anti-bacterial, anti-lipase, anti-keratinocyte proliferation, and anti-inflammatory actions. Hence, PG-E has great potential in the application of anti-acne and skin-care products, and punicalagin (1), the most effective component in PG-E, can be employed as a quality control marker.

  3. First report of Pilidiella granati causing dieback and fruit rot of pomegranate (Punica granatum) in Iran

    NARCIS (Netherlands)

    Mirabolfathy, M.; Groenewald, J.Z.; Crous, P.W.

    2012-01-01

    Iran is the largest producer of pomegranate (Punica granatum) in the world, with more than 60,000 ha currently in production. In the spring of 2011, a decline and dieback of young pomegranate trees (7 to 10 years old) were observed in the Kheir area of Fars Province. Dieback and twig blight

  4. Evaluation of roselle (Hibiscus sabdariffa) leaf and pomegranate (Punica granatum) fruit rind for activity against Meloidogyne incognita

    Science.gov (United States)

    Pomegranate (Punica granatum) fruit and roselle (Hibiscus sabdariffa) leaves have been used in traditional medicine, including as anthelmintics. Methanolic extracts from these plants were investigated for activity against the southern root-knot nematode (RKN) Meloidogyne incognita. Dried, ground p...

  5. Detecção de inibidores de proteases em sementes de Punica granatum

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    Lara Franca Colares

    Full Text Available The use of plants as a way to prevent and treat disease comes from ancient times. With the increasing return on consumption of plants for medicinal purposes, the plant-based medicines have gained greater appreciation. Protease inhibitors are compounds that can decrease activity of an enzyme. They are found in plants, especially in Fabaceae, Poaceae, and Solanaceae families, and show satisfactory use to treat diseases due to their regulatory activities and selective proteolytic degradation of target substrates. This study aimed to obtain protease inhibitors in the seeds of Punica granatum, due its use in traditional medicine. The alcohol-acid solution was used to extract and isolate the protease inhibitors in P. granatum seeds and Glycine max grains. The extract of P. granatum seeds showed similar concentration of protease inhibitors when compared to G. max. A 14 kDa band was detected by electrophoresis on polyacrylamide gel, which was characterized by high-performance liquid chromatography as protease inhibitors. The extract of P. granatum seeds showed a potent trypsin inhibitor activity (EC50 18.2 ng mL-1. This study showed for the first time the extraction, purification, and identification of protease inhibitors in Punica granatum seeds.

  6. The effect of extract of Punica granatum var. pleniflora for treatment of minor recurrent aphthous stomatitis.

    Science.gov (United States)

    Gavanji, Shahin; Larki, Behrouz; Bakhtari, Azizollah

    2014-06-01

    Herbal drugs are considered alternative agents and have been used for several years around the world. Recurrent aphthous stomatitis (RAS) is one of the most common problems recognized by dentists and skin specialists. This problem is characterized by recurring, painful, small oral mucosal ulcers with a round or oval aspect that mostly appear in keratinized mucosa, cheeks, and on the surface of the mouth under the tongue. In our experiment, the alcoholic and water extracts of Punica granatum var. pleniflora, P. granatum var. Sweet Alak, and P. granatum var. Saveh Black were tested on minor RAS. The study was carried out using the double-blind method. The study population consisted of 210 participants, of whom 69 were females (32%) and 141 were males (68%). In addition to checking several factors, the pain and the degree of the participant's satisfaction had been determined based on visual analog scale. Data analysis was done in the form of a nonparametric method using Kruskal-Wallis test and SPSS version 20 software. The results show that the alcoholic and water extracts of P. granatum var. pleniflora have a meaningful therapeutic effect on minor RAS. Results from the antioxidant activity and its relation to total phenolics show that P. granatum var. pleniflora and P. granatum var. Sweet Alak are rich in phenols. The water and alcoholic extracts of P. granatum varpleniflora decreased the entire time of complete treatment, and the treatment was meaningfully satisfactory for patients who participated in this experiment.

  7. Punica granatum juice effects on oxidative stress in severe physical activity.

    Science.gov (United States)

    Naghizadeh-Baghi, Abbas; Mazani, Mohammad; Shadman-Fard, Ali; Nemati, Ali

    2015-02-01

    The aim of this study was to investigate Punica granatum juice effects on oxidative stress in young healthy males during severe physical activity. Our subjects were selected from healthy males at 18 - 24 years. They were enrolled and randomly distributed into control and supplemented groups. 240 ml of Punica granatum juice and tap water were given to supplement and control groups daily for two weeks, respectively. Fasting blood samples were taken at the starting and the end of two weeks of intervention. Subjects were given once severe physical activity and then fasting blood samples were taken. Fasting blood samples were used for testing of oxidative and antioxidative factors. Data were analyzed using descriptive statistical tests, paired samples t-test, and independent samples t-test. The levels of arylesterase, superoxide dismutase, glutathione peroxidase and total antioxidant capacity after severe physical activity in supplement group were significantly increased (pstress and thus protects against severe physical activity oxidative injury in young healthy males.

  8. “Rhetoric to Reality”- Efficacy of Punica Granatum Peel Extract on Oral Candidiasis: An in vitro Study

    Science.gov (United States)

    Reddy, Sudhakara; Koneru, Jyothirmai; Rao, Atla Srinivasa; Sruthi, Rayapureddi; Dalli, Divya Teja

    2017-01-01

    Introduction Global usage of synthetic drugs inadvertently has resulted in deleterious effects and antimicrobial resistance. Phytoextarcts with therapeutic properties appear to be appropriate substitutes for synthetic drugs. Punica granatum (Pomegranate) is a fruit rich in nutraceuticals and therapeutic properties that has lead to its widespread use as folk-medicine for treating innumerable diseases. Aim To determine the in vitro antifungal efficacy of Punica granatum peel extract against the oral Candida compared with clotrimazole. Materials and Methods An in vitro study was carried out on 60 saliva samples collected from patients confirmed by clinical and mycological examination as oral candidiasis and subjected to culture on Saborauds Dextrose Agar (SDA) medium and incubated at 37°C for 48 hours. The cultured Candida species were subjected to antifungal susceptibility test by agar well diffusion method. Punica granatum peel extract (Group-I), Ethanol (Group-II Negative control), Clotrimazole (Group-III-Positive control) were inoculated in wells and incubated. Zones of inhibitions were measured with a digital Vernier’s callipers and subjected to statistical analysis. ANOVA (analysis of variance) was performed to compare inhibition zones and concentrations of all the three groups. Results Antifungal efficacy of Punica granatum group and Clotrimazole group were statistically significant with p-value <0.05. Additionally, with the increase in the concentration there was an increase in the inhibitory efficacy against Candida species. Minimum Inhibitory Concentration (MIC) of peel extract of Punica granatum approximated with that of the clotrimazole. Conclusion The present research was just a venture to usual clinical approach. The results of the study reveal that MIC of peel extract of Punica granatum approximated with that of the clotrimazole. Hence, peel extract of Punica granatum may be used as a substitute for antifungal agents in clinical trials with

  9. "Rhetoric to Reality"- Efficacy of Punica Granatum Peel Extract on Oral Candidiasis: An in vitro Study.

    Science.gov (United States)

    Madugula, Preethi; Reddy, Sudhakara; Koneru, Jyothirmai; Rao, Atla Srinivasa; Sruthi, Rayapureddi; Dalli, Divya Teja

    2017-01-01

    Global usage of synthetic drugs inadvertently has resulted in deleterious effects and antimicrobial resistance. Phytoextarcts with therapeutic properties appear to be appropriate substitutes for synthetic drugs. Punica granatum (Pomegranate) is a fruit rich in nutraceuticals and therapeutic properties that has lead to its widespread use as folk-medicine for treating innumerable diseases. To determine the in vitro antifungal efficacy of Punica granatum peel extract against the oral Candida compared with clotrimazole. An in vitro study was carried out on 60 saliva samples collected from patients confirmed by clinical and mycological examination as oral candidiasis and subjected to culture on Saborauds Dextrose Agar (SDA) medium and incubated at 37°C for 48 hours. The cultured Candida species were subjected to antifungal susceptibility test by agar well diffusion method. Punica granatum peel extract (Group-I), Ethanol (Group-II Negative control), Clotrimazole (Group-III-Positive control) were inoculated in wells and incubated. Zones of inhibitions were measured with a digital Vernier's callipers and subjected to statistical analysis. ANOVA (analysis of variance) was performed to compare inhibition zones and concentrations of all the three groups. Antifungal efficacy of Punica granatum group and Clotrimazole group were statistically significant with p-value <0.05. Additionally, with the increase in the concentration there was an increase in the inhibitory efficacy against Candida species. Minimum Inhibitory Concentration (MIC) of peel extract of Punica granatum approximated with that of the clotrimazole. The present research was just a venture to usual clinical approach. The results of the study reveal that MIC of peel extract of Punica granatum approximated with that of the clotrimazole. Hence, peel extract of Punica granatum may be used as a substitute for antifungal agents in clinical trials with standardization so as to minimize the deleterious effects for patient

  10. Bioautographic test of Punica granatum extracts on Fusarium oxysporum.f .sp.albidinis

    OpenAIRE

    LAOUFI A; BOULENOUAR N.; CHERITI A.; MAROUF A.

    2015-01-01

    Fusarium oxysporum f. sp. albidinis, is among the most aggressive soil fungi causing wilt and rot of date palm. Bayoud disease, caused by Fusarium oxysporum f. sp. albidinis (Foa), is a major limiting factor of the date palm cultivation. In order to look for other alternatives to fight against this fungus, in this work we study the antifungal potency of substances extracted from the peel of Punica granatum . The analysis by the method of direct bioautography allows the detection of 17 bioacti...

  11. Lipid composition of seed oils of different pomegranate (Punica granatum L.) cultivars from Spain

    OpenAIRE

    Luana Fernandes; Pereira, José A.; Isabel Lopéz-Cortés; Salazar, Domingo M.; Elsa Ramalhosa; Susana Casal

    2015-01-01

    Pomegranate (Punica granatum L.) is an ancient fruit tree traditionally cultivated in the Near and Middle East. Presently, its most important growing regions include Afghanistan, Iran, Israel, USA, Italy and Spain, the latter country the largest European exporter. The pomegranate fruit can be divided into several anatomical compartments: outside peel, inside peel, and arils (pulp and seeds), the last part being usually used for consumption as is or for juice, jams and jellies production. Even...

  12. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer.

    Science.gov (United States)

    Lansky, Ephraim P; Newman, Robert A

    2007-01-19

    The last 7 years have seen over seven times as many publications indexed by Medline dealing with pomegranate and Punica granatum than in all the years preceding them. Because of this, and the virtual explosion of interest in pomegranate as a medicinal and nutritional product that has followed, this review is accordingly launched. The pomegranate tree, Punica granatum, especially its fruit, possesses a vast ethnomedical history and represents a phytochemical reservoir of heuristic medicinal value. The tree/fruit can be divided into several anatomical compartments: (1) seed, (2) juice, (3) peel, (4) leaf, (5) flower, (6) bark, and (7) roots, each of which has interesting pharmacologic activity. Juice and peels, for example, possess potent antioxidant properties, while juice, peel and oil are all weakly estrogenic and heuristically of interest for the treatment of menopausal symptoms and sequellae. The use of juice, peel and oil have also been shown to possess anticancer activities, including interference with tumor cell proliferation, cell cycle, invasion and angiogenesis. These may be associated with plant based anti-inflammatory effects, The phytochemistry and pharmacological actions of all Punica granatum components suggest a wide range of clinical applications for the treatment and prevention of cancer, as well as other diseases where chronic inflammation is believed to play an essential etiologic role.

  13. The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats

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    Ebrahim Nasiri

    2017-01-01

    Full Text Available Background. We compared the efficacy of P. granatum (P flower extract with that of silver sulfadiazine (SSD for treating thermal burn injuries in rats. Methods. Ten Wistar rats in each group were topically given base cream, normal saline, cream containing 1% SSD, or creams containing 5% or 10% Punica granatum flower extract. The treatments were administered once daily until complete wound healing was observed. The wound area and healing time were assessed. In addition, percentage wound contraction and histopathological characteristics such as neovascularization and collagen formation were determined. The tannin content in P. granatum extract was determined. Results. The decrease in the average size of wounds on day 15 of the treatment was higher in rats treated with creams containing P. granatum extract than in rats treated with cream containing SSD (2.8±0.9 cm2 versus 8.4±3.2 cm2. The wounds completely healed on day 25 of the treatment in rats treated with creams containing P. granatum flower extract compared with those in rats treated with the other agents. Conclusion. These results indicated that P. granatum flower extract promoted wound healing in rats and could be used for managing burn injuries.

  14. Effect of Punica granatum on the virulence factors of cariogenic bacteria Streptococcus mutans.

    Science.gov (United States)

    Gulube, Zandiswa; Patel, Mrudula

    2016-09-01

    Dental caries is caused by acids produced by biofilm-forming Streptococcus mutans from fermentable carbohydrates and bacterial byproducts. Control of these bacteria is important in the prevention of dental caries. This study investigated the effect of the fruit peel of Punica granatum on biofilm formation, acid and extracellular polysaccharides production (EPS) by S. mutans. Pomegranate fruit peels crude extracts were prepared. The Minimum bactericidal concentrations (MBC) were determined against S. mutans. At 3 sub-bactericidal concentrations, the effect on the acid production, biofilm formation and EPS production was determined. The results were analysed using Kruskal-Wallis and Wilcoxon Rank Sum Tests. The lowest MBC was 6.25 mg/mL. Punica granatum significantly inhibited acid production (p mutans. The crude extract of P. granatum killed cariogenic S. mutans at high concentrations. At sub-bactericidal concentrations, it reduced biofilm formation, acid and EPS production. This suggests that P. granatum extract has the potential to prevent dental caries. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Antibacterial Effect of Hydroalcoholic Extract of Punica granatum Linn. Petal on Common Oral Microorganisms

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    Farnaz Hajifattahi

    2016-01-01

    Full Text Available Objectives. This study aimed to assess the effect of hydroalcoholic extract of Punica granatum Linn. (P. granatum petal on Streptococcus sanguinis, Streptococcus mutans, Streptococcus salivarius, Streptococcus sobrinus, and Enterococcus faecalis. Materials and Methods. In this in vitro study, P. granatum extract was prepared using powdered petals and water-ethanol solvent. Antibacterial effect of the extract, chlorhexidine (CHX, and ampicillin was evaluated on brain heart infusion agar (BHIA using the cup-plate method. By assessing the diameter of the growth inhibition zone, the minimum inhibitory concentration (MIC and minimum bactericidal concentration (MBC of the extract were determined for the above-mentioned bacteria. Results. Hydroalcoholic extract of P. granatum petal had inhibitory effects on the proliferation of all five bacterial strains with maximum effect on S. mutans with MIC and MBC of 3.9 mg/mL. The largest growth inhibition zone diameter belonged to S. sanguinis and the smallest to E. faecalis. Ampicillin and CHX had the greatest inhibitory effect on S. sanguinis. Conclusions. Hydroalcoholic extract of P. granatum had a significant antibacterial effect on common oral bacterial pathogens with maximum effect on S. mutans, which is the main microorganism responsible for dental plaque and caries.

  16. Punica granatum L. Hydrogel for Wound Care Treatment: From Case Study to Phytomedicine Standardization.

    Science.gov (United States)

    Fleck, Aline; Cabral, Patrik F G; Vieira, Felipe F M; Pinheiro, Deo A; Pereira, Carlos R; Santos, Wilson C; Machado, Thelma B

    2016-08-22

    The pharmacological activities of many Punica granatum L. components suggest a wide range of clinical applications for the prevention and treatment of diseases where chronic inflammation is believed to play an essential etiologic role. The current work reports a case study analyzing the effect produced by a magistral formulation of ethanolic extracts of Punica granatum peels on a non-healing chronic ulcer. The complete closure of the chronic ulcer that was initially not responsive to standard medical care was observed. A 2% (w/w) P. granatum peels ethanolic extract hydrogel-based formulation (PGHF) was standardized and subjected to physicochemical studies to establish the quality control parameters using, among others, assessment criteria such as optimum appearance, pH range, viscosity and hydrogel disintegration. The stability and quantitative chromatographic data was assessed in storage for six months under two temperature regimes. An efficient HPLC-DAD method was established distinguishing the biomarkers punicalin and punicalagin simultaneously in a single 8 min run. PGHF presented suitable sensorial and physicochemical performance, showing that punicalagin was not significantly affected by storage (p > 0.05). Formulations containing extracts with not less than 0.49% (w/w) total punicalagin might find good use in wound healing therapy.

  17. Punica granatum L. Hydrogel for Wound Care Treatment: From Case Study to Phytomedicine Standardization

    Directory of Open Access Journals (Sweden)

    Aline Fleck

    2016-08-01

    Full Text Available The pharmacological activities of many Punica granatum L. components suggest a wide range of clinical applications for the prevention and treatment of diseases where chronic inflammation is believed to play an essential etiologic role. The current work reports a case study analyzing the effect produced by a magistral formulation of ethanolic extracts of Punica granatum peels on a non-healing chronic ulcer. The complete closure of the chronic ulcer that was initially not responsive to standard medical care was observed. A 2% (w/w P. granatum peels ethanolic extract hydrogel-based formulation (PGHF was standardized and subjected to physicochemical studies to establish the quality control parameters using, among others, assessment criteria such as optimum appearance, pH range, viscosity and hydrogel disintegration. The stability and quantitative chromatographic data was assessed in storage for six months under two temperature regimes. An efficient HPLC-DAD method was established distinguishing the biomarkers punicalin and punicalagin simultaneously in a single 8 min run. PGHF presented suitable sensorial and physicochemical performance, showing that punicalagin was not significantly affected by storage (p > 0.05. Formulations containing extracts with not less than 0.49% (w/w total punicalagin might find good use in wound healing therapy.

  18. Characterization of a potential nutraceutical ingredient: pomegranate (Punica granatum L.) seed oil unsaponifiable fraction.

    Science.gov (United States)

    Caligiani, Augusta; Bonzanini, Francesca; Palla, Gerardo; Cirlini, Martina; Bruni, Renato

    2010-09-01

    The chemical fingerprinting of the unsaponifiable fraction of different Punica granatum seed oils was performed in order to evaluate their potential as a functional food ingredient. Qualitative and quantitative determinations of tocopherol, aliphatic alcohol (including policosanol), squalene, phytosterols and triterpene contents were performed by GC-MS. A high yield (3.1-4.2%) of unsaponifiable matter was obtained and consistent levels of squalene (up to 800 mg/kg) and policosanol (118-185 mg/kg) were noticed. β-sitosterol (up to 8069 mg/kg) and cycloartenol (5916-7766 mg/kg) were predominant in phytosterol and triterpene fractions, while β- and δ-tocopherol were the most abundant vitamin E forms. Some minor variations were noticed between samples. From the results obtained, it can be suggested that the seed oil of P. granatum can be considered an interesting alimentary source of substances of nutraceutical value involved in the modulation of cholesterol metabolism.

  19. Punica granatum leave extract as green corrosion inhibitor for mild steel in Hydrochloric acid

    OpenAIRE

    Abboud Y.; Chagraoui A.; Tanane O.; El Bouari A.; Hannache H.

    2013-01-01

    Leave of Punica granatum extract (LPGE) as green inhibitor for the corrosion of mild steel in 1M HCl solution was studied using weight-loss and potentiodynamic polarization measurements. The results obtained revealed that LPGE has fairly good inhibiting properties for mild steel corrosion in 1M HCl solution, with efficiency of around 94 % at a concentration of 1 g/l. The inhibition was of a mixed anodic–cathodic nature. The film which is formed over the metal surface was analysed by FT-IR spe...

  20. Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry

    NARCIS (Netherlands)

    van Elswijk, D.A.; Schobel, U.; Lansky, EP; Irth, H.; de Greef, J

    2004-01-01

    During recent years, phytoestrogens have been receiving an increasing amount of interest, as several lines of evidence suggest a possible role in preventing a range of diseases, including the hormonally dependent cancers. In this context, various parts of the pomegranate fruit (Punica granatum;

  1. Behavioral effects of Citrus limon and Punica granatum combinations in rats.

    Science.gov (United States)

    Riaz, Azra; Khan, Rafeeq Alam

    2017-02-01

    Dietary supplements are becoming more influential as viable treatment for common chronic diseases and to promote normal development and functions of all system including brain. Disorders like anxiety and depression may be managed through healthier variations is dietary pattern, since there are indications that diet rich in antioxidants and vitamins diminish anxiety and depression. Hence this investigation was planned to assess the behavioral effects of Citrus limon and Punica granatum in two combination doses i.e. 0.4 + 5 ml/kg and 0.2 + 8 ml/kg C. limon and P. granatum respectively in rats. Antidepressant and anxiolytic effects were explicitly judged twice during 15 days using forced swimming and open field tests and elevated plus maze. In open field test C. limon and P. granatum showed increase in distance travelled, number of central entries and number of rearing's at 0.4 + 5 ml/kg combination, in the elevated plus maze, number of open arm entries were found to be augmented and in forced swimming test, there was decline in duration of immobility and rise in duration of climbing at both combinations i.e. 0.4 + 5 ml/kg and 0.2 + 8 ml/kg C. limon and P. granatum. These results suggest that C. limon and P. granatum at 0.4 + 5 ml/kg combination have anxiolytic and antidepressant effect.

  2. Antibacterial and Antifungal Activities of Punica Granatum Peel Extracts Against Oral Pathogens

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    Sh. Abdollahzadeh

    2011-03-01

    Full Text Available Objective: Punica granatum has been used for many years in folk medicine due to several purposes. The aim of the present study was to evaluate the effect of methanolic extract of Punica granatum peel (MEPGP against Streptococcus mutans, Staphylococcus aureus,Streptococcus salivarius, Streptococcus sanguinis, Staphylococcus epidermidis, Actynomyces viscosus, Lactobacillus acidophilus and Candida albicans.Materials and Methods: In this in vitro study, the mentioned oral organisms were cultured in blood agar and mueller-hinton media and then paper disks containing MEPGP at concentrations of 4 mg/ml, 8 mg/ml and 12 mg/ml were inserted on medias. The antimicrobialactivity was evaluated by agar disk diffusion method. The effects of three different concentrations of MEPGP against microorganisms were compared using one-way ANOVA and Tukey tests.Results: All concentrations of MEPGP had antibacterial activity against S. aureus and S.epidermidis. Only at concentration of 8 mg/ml and 12 mg/ml MEPGP was effective against L. acidophilus, S. mutans and S. salivarius. Furthermore; no concentrations ofMEPGP inhibited A. viscosus and C. albicans.Conclusion: This study suggests that MEPGP might be used as an antibacterial agent in controlling oral infections.

  3. Potential anti-inflammatory effects of the hydrophilic fraction of pomegranate (Punica granatum L.) seed oil on breast cancer cell lines

    National Research Council Canada - National Science Library

    Costantini, Susan; Rusolo, Fabiola; De Vito, Valentina; Moccia, Stefania; Picariello, Gianluca; Capone, Francesca; Guerriero, Eliana; Castello, Giuseppe; Volpe, Maria Grazia

    2014-01-01

    ...% aqueous methanol extract) from pomegranate (Punica granatum L.) seed oil (PSO) and evaluated their anti-inflammatory potential on some human colon (HT29 and HCT116), liver (HepG2 and Huh7), breast...

  4. Antibiotic activity of the extract of Punica granatum Linn. over bovine strains of Staphylococcus aureus

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    Maria A. R. Silva

    Full Text Available Human and veterinary medicines have not been so well succeeded in order to achieving their goals concerning the treatment of infections for long term caused by Staphylococcus aureus linked to resistance development against antibiotic agents. The antibiotic activity of the Punica granatum Linn. fresh fruit pericarp extract was evaluated by the agar diffusion method on 38 S. aureus strains, isolated from apparently healthy lactating cows in farms situated in counties of the semi-arid region of the State of Paraíba, Brazil to determine the minimum inhibitory concentration (MIC. Twenty-two of the thirty-eight strains are penicillin-resistant (PRSA. The extract of P. granatum presented potential antibiotic action over all the assayed strains, forming 10 to 36 mm diameter inhibition zones. This paper's results claim the effectiveness of the extract of P. granatum as a potential antibacterial agent on S. aureus, and display the significance of evaluating new substances with antimicrobial potential, which can contribute to alternative therapeutics for veterinary and medicine.

  5. Antibacterial activity of crude extract of Punica granatum pericarp on pathogenic Gram-negative bacilli.

    Directory of Open Access Journals (Sweden)

    Voravuthikunchai, S.

    2005-08-01

    Full Text Available The objective of this study was to investigate the effect of crude extracts of Punica granatum Linn. pericarp with 3 different solvents against pathogenic Gram-negative bacilli. Ethanolic extracts showed the antibacterial activity against all strains tested including enterohaemorrhagic Escherichia coli 4 strains (E. coli O157: H7, E. coli O26: H11, E. coli O111: NM, E. coli O22, Pseudomonas aeruginosa, Shigella boydii and Salmonella london. Inhibition zones ranged from 10.02 to 19.15 mm. Minimum inhibitory concentration (MIC and minimum bactericidal concentration (MBC ranged from 0.09 to 3.13 mg/ml and 3.13 to 25 mg/ml, respectively. Aqueous extract had low antibacterial activity while crude chloroform extracts had no effect on the growth of these strains. Ethyl acetate and n-butanol fractions of P. granatum pericarp demonstrated high activity with the best MIC and MBC values of 0.02 to 0.78 mg/ml and 0.19 to 6.25 mg/ml, respectively. As ethanolic extract of P. granatum was very effective against these pathogenic bacteria, further investigation on this plant species may provide alternative, but bioactive, medicines for the treatment of Gram-negative bacterial infection.

  6. Punica granatum leave extract as green corrosion inhibitor for mild steel in Hydrochloric acid

    Directory of Open Access Journals (Sweden)

    Abboud Y.

    2013-09-01

    Full Text Available Leave of Punica granatum extract (LPGE as green inhibitor for the corrosion of mild steel in 1M HCl solution was studied using weight-loss and potentiodynamic polarization measurements. The results obtained revealed that LPGE has fairly good inhibiting properties for mild steel corrosion in 1M HCl solution, with efficiency of around 94 % at a concentration of 1 g/l. The inhibition was of a mixed anodic–cathodic nature. The film which is formed over the metal surface was analysed by FT-IR spectroscopy. Further examination using X-ray diffraction confirms the role of LPGE as an effective corrosion inhibitor for mild steel in acid media.

  7. Bioautographic test of Punica granatum extracts on Fusarium oxysporum.f .sp.albidinis

    Directory of Open Access Journals (Sweden)

    LAOUFI A

    2015-11-01

    Full Text Available Fusarium oxysporum f. sp. albidinis, is among the most aggressive soil fungi causing wilt and rot of date palm. Bayoud disease, caused by Fusarium oxysporum f. sp. albidinis (Foa, is a major limiting factor of the date palm cultivation. In order to look for other alternatives to fight against this fungus, in this work we study the antifungal potency of substances extracted from the peel of Punica granatum . The analysis by the method of direct bioautography allows the detection of 17 bioactive substances, Three are indicated in the ethyl acetate extract, two on the level of hexane extract, two in the extract of dichlorométhane, one in the butanol extract and nine on the level of the chloroformic extract. Key Words: sp. Albidinis,

  8. Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins.

    Science.gov (United States)

    González-Trujano, María Eva; Pellicer, Francisco; Mena, Pedro; Moreno, Diego A; García-Viguera, Cristina

    2015-01-01

    Pomegranate (Punica granatum L.) has been used for centuries for the treatment of inflammatory diseases. However, there is a lack of comprehensive information focused on the properties of a certain pomegranate (poly)phenolic profile to cure pain and gastric injury induced by anti-inflammatory drugs. This study investigated the systemic effects of different doses of a HPLC-characterized pomegranate extract on the formalin-induced nociceptive behavior in mice. The effect of the extract against gastric injury caused by non-steroidal anti-inflammatory drugs and ethanol was also assessed. Pomegranate reduced nociception in both phases of the formalin test, suggesting central and peripheral activities to inhibit nociception. Indomethacin-induced gastric injury was not produced in the presence of pomegranate, which also protected against ethanol-induced gastric lesions. The present results reinforce the benefits of pomegranate (poly)phenolics in the treatment of pain as well as their anti-inflammatory properties.

  9. Antibacterial Inhibitory Effects ofPunica GranatumGel on Cariogenic Bacteria: Anin vitroStudy.

    Science.gov (United States)

    Millo, Grazielle; Juntavee, Apa; Ratanathongkam, Ariya; Nualkaew, Natsajee; Peerapattana, Jomjai; Chatchiwiwattana, Supaporn

    2017-01-01

    This study evaluated the in vitro antibacterial effects of the formulated Punica granatum (PG) gel against Streptococcus mutans, Streptococcus sanguinis, and Lactobacillus casei. The PG extract was dissolved in water at 500 mg/mL. High performance liquid chromatography (HPLC) was used for identification and quantification of chemical marker punicalagin. Minimum bactericidal concentration (MBC) and time-kill assay (TKA) were investigated. Antibacterial activities of the formulated PG gel, 2% chlorhexidine (CHX) gel and blank gel were tested by measuring the zones of inhibition through agar well diffusion method. The HPLC results showed presence of punicalagin at 2023.58 ± 25.29 pg/mL in the aqueous PG extract and at 0.234% (w/w) in the formulated PG gel. The MBC for S. mutans, S. Sanguinis, and L. casei were 250, 125, and 500 mg/mL respectively. The TKA of 500 mg/mL aqueous PG extract showed total inhibition of S. mutans, S. Sanguinis, and L. casei at 6, 1, and 24 hours contact time respectively. Agar well diffusion revealed that for S. mutans, CHX gel > PG gel > blank gel; for S. sanguinis, CHX gel = PG gel > blank gel; for L. casei, CHX gel > PG gel = blank gel. Comparison of the PG gel potency showed that S. sanguinis = S. mutans > L. casei. The PG gel equivalent to 0.234% punicalagin (w/w) inhibited S. mutans and S. sanguinis but not L. casei within 24 hours incubation period and has the potential to be used for caries prevention. Millo G, Juntavee A, Ratanathongkam A, Nualkaew N, Peerapattana J, Chatchiwiwattana S. Antibacterial Inhibitory Effects of Punica Granatum Gel on Cariogenic Bacteria: An in vitro Study. Int J Clin Pediatr Dent 2017;10(2):152-157.

  10. Antimicrobial Activity of Six Pomegranate (Punica granatum L. Varieties and Their Relation to Some of Their Pomological and Phytonutrient Characteristics

    Directory of Open Access Journals (Sweden)

    Nurcan Erbil

    2009-05-01

    Full Text Available Arils from six pomegranate (Punica granatum L. varieties grown in the Mediterranean region of Turkey were tested for their antimicrobial properties by the agar diffusion and minimum inhibitory concentration (MIC methods against seven bacteria: (Bacillus megaterium DSM 32, Pseudomonas aeruginosa DSM 9027, Staphylococcus aureus Cowan 1, Corynebacterium xerosis UC 9165, Escherichia coli DM, Enterococcus faecalis A10, Micrococcus luteus LA 2971, and threefungi (Kluvyeromyces marxianus A230, Rhodotorula rubra MC12, Candida albicans ATCC 1023. It has been observed that the pomegranate aril extracts had antimicrobial effect on all microorganisms, giving inhibition zones ranging in size from 13 to 26 mm. The MIC values for active pomegranate extracts ranged between 30 and >90 µg/mL. The results obtained appeared to confirm the antimicrobial potential of the Punica granatum varieties.

  11. Bioactivity of Nonedible Parts of Punica granatum L.: A Potential Source of Functional Ingredients

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    Nawraj Rummun

    2013-01-01

    Full Text Available Punica granatum L. has a long standing culinary and medicinal traditional use in Mauritius. This prompted a comparative study to determine the bioefficacy of the flower, peel, leaf, stem, and seed extracts of the Mauritian P. granatum. The flower and peel extracts resulting from organic solvent extraction exhibited strong antioxidant activities which correlated with the high levels of total phenolics, flavonoids, and proanthocyanidins. The peel extract had the most potent scavenging capacity reflected by high Trolox equivalent antioxidant capacity value ( μmol/g air dry weight, very low IC50 values for hypochlorous acid ( mg air dry weight/mL, and hydroxyl radicals scavenging ( mg air dry weight/mL. Peel extracts also significantly inhibited S. mutans (, S. mitis (, and L. acidophilus ( growth compared to ciprofloxacin. The flower extract exhibited high ferric reducing, nitric oxide scavenging, and iron (II ions chelation and significantly inhibited microsomal lipid peroxidation. Furthermore, it showed a dose-dependent inhibition of xanthine oxidase with an IC50 value of  mg air dry weight/mL. This study showed that nonedible parts of cultivated pomegranates, that are generally discarded, are bioactive in multiassay systems thereby suggesting their potential use as natural prophylactics and in food applications.

  12. Atividade citotóxica e antiangiogênica de Punica granatum L., Punicaceae

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    Ligianne P. Oliveira

    Full Text Available Punica granatum L., Punicaceae, amplamente usada no Brasil, foi avaliada quanto ao seu potencial antitumoral in vitroe in vivo. Investigou-se in vitro a citotoxicidade do extrato etanólico do fruto e folha da P. granatumutilizando células K-562 e células do Tumor Ascítico de Ehrlich (TAE, pelos métodos de redução do MTT e exclusão do azul de tripano. Nos estudos in vivoavaliou-se o aumento da sobrevida de animais portadores do TAE e tratados, por via oral, com diferentes doses dos extratos etanólicos da P. granatum(12,5; 25; 50 e 100 mg/kg por dez dias consecutivos. Além disso, nestes animais analisou-se o potencial de inibição tumoral e a atividade antiangiogênica da P. granatum. Os resultados dos estudos in vitrodemonstraram uma redução na viabilidade das células K-562 e do TAE, concentração-dependente, nos métodos investigados. Os resultados in vivo demonstraram aumento da sobrevida dos animais portadores do TAE tratados, de forma dose-dependente. Em paralelo, observou-se diminuição do número de células tumorais na cavidade peritoneal dos animais portadores e tratados. Além disto, os tratamentos empregados reduziram o padrão de vascularização da parede abdominal. Dessa forma, os dados apresentados revelaram que o extrato de P. granatumpossui atividade antitumoral in vitroe in vivo em paralelo a redução da angiogênese peritoneal.

  13. Antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans: an in vitro study.

    Science.gov (United States)

    Pai, Mithun B H; Prashant, G M; Murlikrishna, K S; Shivakumar, K M; Chandu, G N

    2010-01-01

    The establishment and maintenance of oral microbiota is related not only to interbacterial coaggregations but also to interactions of these bacteria with yeasts. Hence, it is important for agents used in the treatment of oral diseases to have antifungal properties for effective therapy. The main purpose of this study was to evaluate the in vitro antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans. The pomegranate peel is separated, dried and powdered. Fennel, cumin and acacia bark obtained from the tree are powdered. Candida is inoculated at 37˚C and seeded on Sabourauds agar medium. Sterilized filter papers saturated with 30 μl of the extracts are placed on the seeded plates and inoculated at 24 and 48 h. Zones of inhibition on all four sides are measured around the filter paper with a vernier caliper. The experiments were repeated on four plates, with four samples of each extract on one plate for all of the extracts. All the above-mentioned ingredients showed antifungal property, with Punica granatum showing the highest inhibition of Candida albicans with a mean zone of inhibition of 22 mm. P-values <0.05 were obtained for Punica granatum when compared with the other extracts. The results showed the potential use of these products as cheap and convenient adjuvants to pharmaceutical antifungal products.

  14. Antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans: An in vitro study

    Directory of Open Access Journals (Sweden)

    Pai Mithun

    2010-01-01

    Full Text Available Background: The establishment and maintenance of oral microbiota is related not only to interbacterial coaggregations but also to interactions of these bacteria with yeasts. Hence, it is important for agents used in the treatment of oral diseases to have antifungal properties for effective therapy. Objective: The main purpose of this study was to evaluate the in vitro antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans. Materials and Methods: The pomegranate peel is separated, dried and powdered. Fennel, cumin and acacia bark obtained from the tree are powdered. Candida is inoculated at 37˚C and seeded on Sabourauds agar medium. Sterilized filter papers saturated with 30 μl of the extracts are placed on the seeded plates and inoculated at 24 and 48 h. Zones of inhibition on all four sides are measured around the filter paper with a vernier caliper. The experiments were repeated on four plates, with four samples of each extract on one plate for all of the extracts. Results: All the above-mentioned ingredients showed antifungal property, with Punica granatum showing the highest inhibition of Candida albicans with a mean zone of inhibition of 22 mm. P-values <0.05 were obtained for Punica granatum when compared with the other extracts. Conclusion: The results showed the potential use of these products as cheap and convenient adjuvants to pharmaceutical antifungal products.

  15. Pomegranate (Punica granatum) Juice Shows Antioxidant Activity against Cutaneous Leishmaniasis-Induced Oxidative Stress in Female BALB/c Mice.

    Science.gov (United States)

    Alkathiri, Badriah; El-Khadragy, Manal F; Metwally, Dina M; Al-Olayan, Ebtesam M; Bakhrebah, Muhammed A; Abdel Moneim, Ahmed E

    2017-12-18

    Leishmania species are parasites that multiply within phagocytes and cause several clinical diseases characterized by single or multiple ulcerations. One of the complications that can induce tissue damage and the resulting scars is caused by secondary bacterial infections. Studies to find new, effective, and safe oral drugs for treating leishmaniasis are being conducted since several decades, owing to the problems associated with the use of antimonials available. Previously, the antiparasitic and antioxidant properties of Punica granatum (pomegranate, P. granatum ) have been reported. Therefore, in the present study, we aimed to investigate the antileishmanial activity of pomegranate aqueous juice in vitro and in female BALB/c mice. A 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in Leishmania major promastigotes and alterations in the antioxidant status, liver function, and skin histological changes in L. major -infected mice orally treated with pomegranate juice alone and in combination with the antibiotic ciprofloxacin, were used to investigate the in vitro and in vivo antileishmanial activity of pomegranate juice, respectively. Oral P. granatum juice treatment significantly reduced the average size of cutaneous leishmaniasis lesions compared with that of the untreated mice. This antileishmanial activity of P. granatum was associated with enhanced antioxidant enzyme activities. Histopathological evaluation proved the antileishmanial activity of P. granatum , but did not reveal changes in the treated animals, compared to the positive control. In conclusion, P. granatum shows high and fast antileishmanial activity probably by boosting the endogenous antioxidant activity.

  16. Attenuation of diabetic nephropathy in streptozotocin-induced diabetic rats by Punica granatum Linn. leaves extract

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    Snehal Nitin Mestry

    2017-07-01

    Full Text Available With an objective to develop Complementary and Alternative Medicine for the treatment of diabetic nephropathy, the present study investigated the protective effects of methanolic extract of Punica granatum leaves (MPGL in streptozotocin-induced diabetic nephropathy. Diabetic nephropathy has become a leading cause of end stage renal failure worldwide. P. granatum, due to its anti-diabetic, anti-inflammatory and antioxidant activities may retard the progression of diabetic nephropathy. In this study, diabetes was induced by a single injection of streptozotocin (STZ, 45 mg/kg, i.p. in rats. STZ-diabetic rats were treated with oral doses of MPGL (100, 200 and 400 mg/kg for 8 weeks. At the end of the experimental period, body and kidney weight and blood glucose levels were determined. Serum and urine parameters were investigated. Antioxidant enzymes and lipid peroxide levels were determined in the kidney along with histopathological examination of the same. MPGL significantly increased body weight, lowered blood glucose levels and ameliorated kidney hypertrophy index in the STZ-diabetic rats. The extract also decreased the levels of creatinine, blood urea nitrogen, total cholesterol, triglycerides, advanced glycation end products and albumin in serum and urine, respectively. MPGL significantly increased the antioxidant parameters in the kidney. Histological evaluation revealed that MPGL treated STZ-diabetic rats demonstrated reduced vacuolar degeneration of tubules; periodic acid Schiff base (PAS positivity staining intensity in glomeruli and basement membrane thickening. Present findings provide experimental evidence that MPGL has potential antioxidant, antihyperglycemic and anti-glycation activities which might be helpful in slowing the progression of diabetic nephropathy.

  17. Anthelmintic potential of Calotropis procera, Azadirachta indica and Punica granatum against Gastrothylax indicus.

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    Aggarwal, Rama; Kaur, Kiranjeet; Suri, Mansi; Bagai, Upma

    2016-12-01

    Anthelmintic activity of both ethanolic and aqueous extracts of Calotropis procera flowers, Azadirachta indica leaves and Punica granatum fruit peel in comparison with albendazole was evaluated through in vitro studies by the worm motility inhibition assay. Significant anthelmintic effects (p Gastrothylax indicus worm as evident from their mortality at 4 h post exposure to both ethanolic and aqueous extracts. Phytochemical analysis of extracts revealed the presence of phenols, alkaloids, saponins, tannins, flavonoids, steroids and triterpenoids. LC-50 values were determined to be 12.05 mg/ml ± 3.24 and 23.52 mg/ml ± 6.4 for C. procera, 24.37 mg/ml ± 4.11 and 21.02 mg/ml ± 4.6 for A. indica, 18.92 mg/ml ± 4.54 and 24.43 mg/ml ± 6.96 for P. granatum ethanolic and aqueous extracts respectively, whereas it was 29.23 μg/ml ± 4.51 for albendazole. The mean mortality index (MI) was 1.0 and 0.90 for C. procera, 0.90 for A. indica and 0.73 and 0.80 for P. granatum ethanolic and aqueous extracts respectively whereas for albendazole it was 1.0. Percent mean worm motility inhibition (%WMI) was observed to be between 70 and 100 % for different extracts.Various concentrations (5-5000 μg/ml) of all the plant extracts and albendazole were used to detect their cytotoxic effects against HeLa cell line to determine CC-50 by MTT assay. CC-50 values, of all the plant extracts were determined to be >1000 μg/ml and for albendazole it was found to be >10 μM. All the three plants can be potential sources for novel anthelmintics.

  18. Evaluation of pomegranate (Punica granatum pericarp aqueous extract on Eimeria spp. from Japanese quails (Coturnix japonica

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    Bruno P. Berto

    2014-06-01

    Full Text Available Antibacterial, anti-inflammatory and antiparasitic properties have been associated with the extract of pomegranate (Punica granatum in several animals and conditions. The Japanese quail (Coturnix japonica, originated from North Africa, Europe and Asia, is used worldwide as an experimental animal and model for aviculture. The current study investigated the effects of the pomegranate pericarp aqueous extract on the shedding, viability and morphometry of three Eimeria spp. from Japanese quails, besides the weight gain and genotoxic activity. Although the pomegranate is recognized by multiple properties, including anti-coccidial, in the current study the results are contrary. The treated group shed greater amount of oocysts; the sporulation times and viability were similar in both groups; despite some morphometric differences, these were not expressive; weight gains were similar; and the pomegranate had insignificant effect genotoxic. Finally, these results suggest that the pomegranate pericarp extract did not influence on Eimeira spp. from Japanese quails; therefore, the pomegranate pericarp extract is not suggested in the prevention/treatment of coccidiosis in Japanese quails, or at least not using methods of preparation and administration applied in this study.

  19. Oxidative Stability of Pomegranate (Punica granatum L.) Seed Oil to Simulated Gastric Conditions and Thermal Stress.

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    Siano, Francesco; Addeo, Francesco; Volpe, Maria Grazia; Paolucci, Marina; Picariello, Gianluca

    2016-11-09

    The fatty acid composition of pomegranate (Punica granatum L.) seed oil (PSO) is dominated by punicic acid, a conjugated linolenic acid (18:3ω-5). As a free fatty acid, punicic acid is rapidly oxidized in air and extensively isomerizes upon acid-catalyzed methylation at 90 °C. In contrast, triacylglycerol-bound punicic acid in PSO was unchanged by simulated gastric conditions and was degraded by 5-7% by severe heating (up to 170 °C for 4 h), as herein assessed by gas chromatography, attenuated total reflectance-Fourier transform infrared spectroscopy, (1)H and (13)C NMR, and high-resolution electrospray ionization mass spectrometry. Total polar compounds of PSO were slightly affected by thermal stress, accounting for 5.71, 6.35, and 9.53% (w/w) in the unheated, heated at mild temperature (50 °C, 2 h), and heated at frying temperature (170 °C, 4 h) PSO, respectively. These findings support from a structural standpoint the potential use of PSO as a health-promoting edible oil.

  20. Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum

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    Sheng Wu

    2017-09-01

    Full Text Available Having served as a symbolic fruit since ancient times, pomegranate (Punica granatum has also gained considerable recognition as a functional food in the modern era. A large body of literature has linked pomegranate polyphenols, particularly anthocyanins (ATs and hydrolyzable tannins (HTs, to the health-promoting activities of pomegranate juice and fruit extracts. However, it remains unclear as to how, and to what extent, the numerous phytochemicals in pomegranate may interact and exert cooperative activities in humans. In this review, we examine the structural and analytical information of the diverse phytochemicals that have been identified in different pomegranate tissues, to establish a knowledge base for characterization of metabolite profiles, discovery of novel phytochemicals, and investigation of phytochemical interactions in pomegranate. We also assess recent findings on the function and molecular mechanism of ATs as well as urolithins, the intestinal microbial derivatives of pomegranate HTs, on human nutrition and health. A better understanding of the structural diversity of pomegranate phytochemicals as well as their bioconversions and bioactivities in humans will facilitate the interrogation of their synergistic/antagonistic interactions and accelerate their applications in dietary-based cancer chemoprevention and treatment in the future.

  1. The pomegranate (Punica granatum L.) genome and the genomics of punicalagin biosynthesis.

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    Qin, Gaihua; Xu, Chunyan; Ming, Ray; Tang, Haibao; Guyot, Romain; Kramer, Elena M; Hu, Yudong; Yi, Xingkai; Qi, Yongjie; Xu, Xiangyang; Gao, Zhenghui; Pan, Haifa; Jian, Jianbo; Tian, Yinping; Yue, Zhen; Xu, Yiliu

    2017-09-01

    Pomegranate (Punica granatum L.) is a perennial fruit crop grown since ancient times that has been planted worldwide and is known for its functional metabolites, particularly punicalagins. We have sequenced and assembled the pomegranate genome with 328 Mb anchored into nine pseudo-chromosomes and annotated 29 229 gene models. A Myrtales lineage-specific whole-genome duplication event was detected that occurred in the common ancestor before the divergence of pomegranate and Eucalyptus. Repetitive sequences accounted for 46.1% of the assembled genome. We found that the integument development gene INNER NO OUTER (INO) was under positive selection and potentially contributed to the development of the fleshy outer layer of the seed coat, an edible part of pomegranate fruit. The genes encoding the enzymes for synthesis and degradation of lignin, hemicelluloses and cellulose were also differentially expressed between soft- and hard-seeded varieties, reflecting differences in their accumulation in cultivars differing in seed hardness. Candidate genes for punicalagin biosynthesis were identified and their expression patterns indicated that gallic acid synthesis in tissues could follow different biochemical pathways. The genome sequence of pomegranate provides a valuable resource for the dissection of many biological and biochemical traits and also provides important insights for the acceleration of breeding. Elucidation of the biochemical pathway(s) involved in punicalagin biosynthesis could assist breeding efforts to increase production of this bioactive compound. © 2017 The Authors The Plant Journal © 2017 John Wiley & Sons Ltd.

  2. Antioxidant capacity changes of 3 cultivar Chinese pomegranate (Punica granatum L.) juices and corresponding wines.

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    Zhuang, Huiting; Du, Jinhua; Wang, Yongmei

    2011-05-01

    This study investigated the antioxidant capacities that included Ferric reducing antioxidant power (FRAP), 1, 1-diphenyl-2-picryl hydrazine (DPPH), ·OH and O(2·)(-)-scavenging abilities, total polyphenols (TP) and total anthocyanins (TA) in pomegranate (Punica granatum L.) juice (PJ) and pomegranate wine (PW). The correlations among them were also analyzed. Both PJ and PW showed significantly high TP and antioxidant capacities, but some differences existed among these cultivars. There was 1596.67 mg/L TP found in sweet PJ, while sour PJ showed the highest titratable acidity of 35.90 g/L and lowest pH value at 2.56. Red PJ was found to have the highest TA (82.26 mg/L) in the 3 cultivars. Sweet PJ showed higher DPPH-scavenging ability and higher FRAP than others. Both PJ and PW exhibited high and relatively stable ·OH-scavenging abilities, in which sour PJ and sour PW had higher O(2·)(-) scavenging capacity than others. Significant positive correlations were observed among TP, DPPH, and FRAP in both PJ and PW. A high correlation between antioxidant capacities and TP indicated that phenolic compounds were major contributors to the high antioxidant activity of PJ and PW. © 2011 Institute of Food Technologists®

  3. EXTRACT OF Punica granatum L.: AN ALTERNATIVE TO BHT AS AN ANTIOXIDANT IN SEMISSOLID EMULSIFIED SYSTEMS

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    Jéssica Tiago Tozetto

    Full Text Available Pomegranate (Punica granatum L. is a fruit which has important pharmacological activities and has been attracting attention due to its important antioxidant activity, a significant feature in relation to cosmetics. Formulations containing different concentrations of an ethanolic extract of pomegranate (0.1, 1.0 and 5.0% (w/w as an antioxidant agent showed that this is an interesting alternative for the use of natural products with biological activity. The stability and rheology of semissolid systems containing an extract of this plant were evaluated. Preliminary stability studies showed greater physico-chemical stability of the formulation, and thus it was used in an accelerated stability study, as well the quantification of total phenolic compounds and the determination of antioxidant activity. It was observed that different concentrations of the extract did not significantly influence the stability. Moreover, the formulation was found to have better stability when stored at room temperature than under heated or cooled conditions. Formulations containing 0.1 and 5.0% of extract showed more stable rheological behavior, due to the absence of a solid/liquid transition in the rheogram. Tests confirmed the high phenolic content and antioxidant activity, demonstrating the potential of this plant for use in cosmetology as an antioxidant.

  4. Lipid Lowering Effect of Punica granatum L. Peel in High Lipid Diet Fed Male Rats

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    Alireza Sadeghipour

    2014-01-01

    Full Text Available Many herbal medicines have been recommended for the treatment of dyslipidemia. The antilipidemic effect of hydroethanolic extract of pomegranate peel (Punica granatum L. was investigated in high lipid diet fed male rats. Intraperitoneally administration of pomegranate peel extract (50, 100, 200, and 300 mg/kg body weight for 23 days on the levels of serum cholesterol, triglycerides, LDL, HDL, alkaline phosphatase (AP, aspartate aminotransferase (AST, and alanine aminotransferase (ALT in high lipid diet fed male rats was evaluated. Treatment of pomegranate extract decreased body weight in treated rats, significantly. Administration of the plant extract significantly decreased serum total cholesterol, triglycerides, LDL-C, alkaline phosphatise, AST, and ALT levels, whereas it increased serum HDL-C in high lipid diet fed rats in comparison to saline control group. Also, histopathological study showed that treatment of pomegranate peel extract attenuates liver damage in high lipid diet fed rats in comparison to saline group. It is concluded that the plant should be considered as an excellent candidate for future studies on dyslipidemia.

  5. Inhibitory Effects of Two Varieties of Tunisian Pomegranate (Punica granatum L.) Extracts on Gastrointestinal Transit in Rat.

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    Souli, Abdelaziz; Sebai, Hichem; Rtibi, Kais; Chehimi, Latifa; Sakly, Mohsen; Amri, Mohamed; El-Benna, Jamel; Marzouki, Lamjed

    2015-09-01

    The present study was undertaken to determine whether total and methanol juice extracts of two Tunisian Pomegranate (Punica granatum L.) varieties (Garsi and Gabsi) protect against diarrhea as well as their effects on gastrointestinal transit (GIT) in healthy rats. In this respect, male Wistar rats were used and divided into control- and pomegranate-treated groups. The antidiarrheal activity was evaluated using the castor oil-induced diarrhea method and the GIT was assessed using charcoal meal. Our results showed that total and methanol P. granatum juice extracts produced a significant dose-dependent protection against castor oil-induced diarrhea. Pomegranate extracts and juice also decreased the GIT significantly and dose dependently. Importantly, the Garsi variety appeared to be more effective than the Gabsi variety on these two parameters. These findings suggest that pomegranate extracts have a potent antidiarrheal property in rats confirming their efficiency in the Tunisian traditional medicine.

  6. Chemical analysis of Punica granatum fruit peel and its in vitro and in vivo biological properties.

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    Barathikannan, Kaliyan; Venkatadri, Babu; Khusro, Ameer; Al-Dhabi, Naif Abdullah; Agastian, Paul; Arasu, Mariadhas Valan; Choi, Han Sung; Kim, Young Ock

    2016-07-30

    The medical application of pomegranate fruits and its peel is attracted human beings. The aim of the present study was to evaluate the in vitro α-Glucosidase inhibition, antimicrobial, antioxidant property and in vivo anti-hyperglycemic activity of Punica granatum (pomegranate) fruit peel extract using Caenorhabditis elegans. Various invitro antioxidant activity of fruit peel extracts was determined by standard protocol. Antibacterial and antifungal activities were determined using disc diffusion and microdilution method respectively. Anti-hyperglycemic activity of fruit peel was observed using fluorescence microscope for in vivo study. The ethyl acetate extract of P. granatum fruit peel (PGPEa) showed α-Glucosidase inhibition upto 50 % at the concentration of IC50 285.21 ± 1.9 μg/ml compared to hexane and methanol extracts. The total phenolic content was highest (218.152 ± 1.73 mg of catechol equivalents/g) in ethyl acetate extract. PGPEa showed more scavenging activity on 2,2-diphenyl-picrylhydrazyl (DPPH) with IC50 value 302.43 ± 1.9 μg/ml and total antioxidant activity with IC50 294.35 ± 1.68 μg/ml. PGPEa also showed a significant effecton lipid peroxidation IC50 208.62 ± 1.68 μg/ml, as well as high reducing power. Among the solvents extracts tested, ethyl acetate extract of fruit peel showed broad spectrum of antimicrobial activity. Ethyl acetate extract supplemented C.elegans worms showed inhibition of lipid accumulation similar to acarbose indicating good hypoglycemic activity. The normal worms compared to test (ethyl acetate extract supplemented) showed the highest hypoglycaemic activity by increasing the lifespan of the worms. GC-MS analysis of PGPEa showed maximum amount of 5-hydroxymethylfurfural and 4-fluorobenzyl alcohol (48.59 %). In the present investigation we observed various biological properties of pomegranate fruit peel. The results clearly indicated that pomegranate peel extract could be used in preventing

  7. Design, Formulation and Evaluation of an Oral Gel from Punica Granatum Flower Extract for the Treatment of Recurrent Aphthous Stomatitis

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    Abolfazl Aslani

    2016-09-01

    Full Text Available Purpose: Recurrent aphthous stomatitis is a disease with unknown etiology that’s mostly treated symptomatically and has no definite cure. Pomegranate (Punica granatum flowers have been used as medicinal herb that due to its antimicrobial, antioxidant, anti-inflammatory, analgesic and healing effects, has been useful in treatment of oral aphthous. Therefore, we decided to formulate a mucoadhesive gel with pomegranate flower extract to reduce the need for corticosteroid therapy in patients. Methods: Pomegranate flowers are extracted by percolation method. Several formulations with different amounts of carbomer 934, sodium carboxymethylcellulose (SCMC and hydroxypropyl methylcellulose K4M were prepared and the condensed extract was dispersed in polyethyleneglycol (PEG 400 and added to gel bases. Then the formulations underwent macroscopic and microscopic studies. The formulations that passed these tests successfully were studied through assay tests using spectrophotometry in 765 nm, drug release from mucoadhesive gel using cell diffusion method, viscosity test, mucoadhesion test and accelerated stability test. Results: The phenolic content of pomegranate flower dried extract was found to be 212.3±1.4 mg/g in dried extract. The F4–F6 formulations contains carbomer 934, SCMC, pomegranate flower extract, PEG 400, potassium sorbate and purified water passed all above tests. Conclusion: The F4 formulation had higher viscosity and mucoadhesion values due to its higher carbomer 934 and SCMC content. Since F4, F5 and F6 had no significant variation in drug release, the F4 formulation was chosen as the superior formulation because of proper appearance and uniformity, acceptable viscosity, mucoadhesion and stability in different temperatures.

  8. Lipid composition of seed oils of different pomegranate (Punica granatum L. cultivars from Spain

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    Luana Fernandes

    2015-04-01

    Full Text Available Pomegranate (Punica granatum L. is an ancient fruit tree traditionally cultivated in the Near and Middle East. Presently, its most important growing regions include Afghanistan, Iran, Israel, USA, Italy and Spain, the latter country the largest European exporter. The pomegranate fruit can be divided into several anatomical compartments: outside peel, inside peel, and arils (pulp and seeds, the last part being usually used for consumption as is or for juice, jams and jellies production. Even though pomegranate seeds are an industrial by-product, recent reports have highlighted their potential use as a source of oil with beneficial chemical attributes. Therefore, the main objective of the present work was to characterize the seed oil of nine European pomegranate varieties, collected in Spain, for their fatty acid and vitamin E compositions. All seed lipid fractions consisted mainly of punicic acid (c9,t11,c13 C-18:3, ranging between 77.3% and 83.6% of total fatty acids, followed by small amounts of linoleic acid (C18:2n6, oleic acid (C18:1n9 and palmitic acid (C16:0. Regarding vitamin E composition, α-, γ-, δ-tocopherols were found in all pomegranate seed oils, but mainly γ-tocopherol, with total tocopherols ranging from 174.5 to 627.3 mg/100g oil.The richness of these pomegranate varieties seed oils in punicic acid, a conjugated linolenic acid with interesting anti-carcinogenic activity, and the elevated amount of tocopherols on the extracted lipids, of technological and nutritional relevance, make this by-product interesting for further exploitation.

  9. Anti Tumoral Properties of Punica Granatum (Pomegranate) Peel Extract on Different Human Cancer Cells.

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    Modaeinama, Sina; Abasi, Mozhgan; Abbasi, Mehran Mesgari; Jahanban-Esfahlan, Rana

    2015-01-01

    Medicinal plants, especially examples rich in polyphenolic compounds, have been suggested to be chemopreventive on account of antioxidative properties. Punica granatum (PG) (pomegranate) is a well known fruit in this context, but its cytotoxicity in cancer cells has not been extensively studied. Here, we investigated the antiproliferative properties of a peel extract of PG from Iran in different human cancer cells. A methanolic extract of pomegranate peel (PPE) was prepared. Total phenolic content(TPC) and total flavonoid conetnt (TFC) were determined by colorimetric assays. Antioxidant activity was determined by DPPH radical scavenging activity. The cytotoxicity of different doses of PPE (0, 5, 20, 100, 250, 500, 1000 μg/ml) was evaluated by MTT assays with A549 (lung non small cell cancer), MCF-7 (breast adenocarcinoma), SKOV3 (ovarian cancer), and PC-3 (prostate adenocarcinoma) cells. Significant (Pcancer cells, PPE reduced the cell viability to values below 40%, even at the lowest doses. In all cases, IC50 was determined at doses below 5μg/ml. In this regard, MCF-7 breast adenocarcinoma cells were the most responsive cells to antiprolifreative effects of PPE with a maximum mean growth inhibition of 81.0% vs. 69.4%, 79.3% and 77.5% in SKOV3, PC-3 and A549 cells, respectively. Low doses of PPE exert potent anti-proliferative effects in different human cancer cells and it seems that MCF-7 breast adenocarcinoma cells are the most cells and SKOV3 ovarian cancer cells the least responsive in this regard. However, the mechanisms of action need to be addressed.

  10. Protective effects of pomegranate (Punica granatum) juice on testes against carbon tetrachloride intoxication in rats.

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    Al-Olayan, Ebtesam M; El-Khadragy, Manal F; Metwally, Dina M; Abdel Moneim, Ahmed E

    2014-05-22

    Pomegranate fruit has been extensively used as a natural medicine in many cultures. The present study was aimed at evaluating the protective effects of pomegranate (Punica granatum) juice against carbon tetrachloride (CCl4)-induced oxidative stress and testes injury in adult Wistar rats. Twenty eight Wistar albino male rats were divided equally into 4 groups for the assessment of protective potential of pomegranate juice. Rats of group I (control) received only vehicles and had free access to food and water. Rats of groups II and IV were treated with CCl4 (2 ml/kg bwt) via the intraperitoneal route once a week for ten weeks. The pomegranate juice was supplemented via drinking water 2 weeks before and concurrent with CCl4 treatment to group IV. Group III was supplemented with pomegranate juice for twelve weeks. The protective effects of pomegranate on serum sex hormones, oxidative markers, activities of antioxidant enzymes and histopathology of testes were determined in CCl4-induced reproductive toxicity in rats. Pomegranate juice showed significant elevation in testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) those depleted by the injection of CCl4. Activity levels of endogenous testesticular antioxidant enzymes; superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) and glutathione (GSH) contents were increased while lipid peroxidation (LPO) and nitric oxide (NO) were decreased with pomegranate juice. Moreover, degeneration of germ and Leydig cells along with deformities in spermatogenesis induced after CCl4 injections were restored with the treatment of pomegranate juice. The results clearly demonstrated that pomegranate juice augments the antioxidant defense mechanism against carbon tetrachloride-induced reproductive toxicity and provides evidence that it may have a therapeutic role in free radical mediated diseases.

  11. Evaluation of the effect of Punica granatum juice and punicalagin on NFκB modulation in inflammatory bowel disease.

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    Shah, Tanmay A; Parikh, Mihir; Patel, Kirti V; Patel, Kalpana G; Joshi, Chaitanya G; Gandhi, Tejal R

    2016-08-01

    Punica granatum L. (Lythraceae) inhibits cancer cell proliferation and apoptosis through the modulation of cellular transcription factors and signaling proteins. No pharmacological work is reported on the effects of P. granatum juice on the cellular signaling pathways involved in initiation and progression of inflammation. The present investigation evaluates the effect of P. granatum juice (PJ) and purified punicalagin (PW) on nuclear factor kappa B (NFκB) and the signaling pathways leading to its expression in colon inflammation. Male Sprague-Dawley rats were divided into six groups: positive and negative control, vehicle (50 % ethanol), standard (5-ASA 100 mg/kg, p.o.), PJ (400 mg/kg, p.o.), PW (4 mg/kg, p.o.). Colitis was induced with 2,4-dinitrobenzene sulfonic acid and animals were euthanized on 18th day. Colon samples collected were subjected to various histological assessment (CMDI, DAI), and biochemical parameters (MPO, MDA, SOD, NO). Gene expression study was carried out using RT-PCR for cytokines (TNF-α, IL-1β, IL-18 and NF-κβ). Pretreatment with PJ and PW significantly (p punicalagin alone and can be potentially used for the treatment of inflammatory bowel disease.

  12. Anti-inflammatory potential of ellagic acid, gallic acid and punicalagin A&B isolated from Punica granatum.

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    BenSaad, Lamees A; Kim, Kah Hwi; Quah, Chin Chew; Kim, Wee Ric; Shahimi, Mustafa

    2017-01-14

    Punica granatum (pomegranate), an edible fruit originating in the Middle East, has been used as a traditional medicine for treatment of pain and inflammatory conditions such as peptic ulcer. The numerous risks associated with nonsteroidal anti-inflammatory drugs (NSAIDs) for treatment of pain and inflammation give rise to using medicinal herbs as alternative therapies. This study aimed to evaluate the anti-inflammatory effect of isolated compounds from the ethyl acetate (EtOAc) fraction of P. granatum by determination of their inhibitory effects on lipopolysaccharide (LPS), stimulated nitric oxide (NO), prostaglandin E2 (PGE-2), interleukin-6 (IL-6) and cyclooxxgenase-2 (COX-2) release from RAW264.7 cells. The compounds ellagic acid, gallic acid and punicalagin A&B were isolated from EtOAc by high performance liquid chromatography (HPLC) and further identified by mass spectrometry (MS). The inhibitory effect of ellagic acid, gallic acid and punicalagin A&B were evaluated on the production of LPS-induced NO by Griess reagent, PGE-2 and IL-6 by immunoassay kit and prostaglandin E2 competitive ELISA kit, and COX-2 by Western blotting. Ellagic acid, gallic acid and punicalagin A&B potentially inhibited LPS-induced NO, PGE-2 and IL-6 production. The results indicate that ellagic acid, gallic acid and punicalagin may be the compounds responsible for the anti-inflammatory potential of P. granatum.

  13. Antifungal activity of acetone extracts from Punica granatum L., Quercus suber L. and Vicia faba L.

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    Akroum, S

    2017-03-01

    Human and animal mycoses become more frequent and more resistant to traditional treatments. In this work, we tested the in vitro antifungal activity of acetonic extracts of Punica granatum L., Quercus suber L. and Vicia faba L. against seven pathogen fungi and the in vivo antifungal activity against Candida albicans and Trichophyton mentagrophytes. The phytochemical screening was also carried out and showed that the extracts contained mainly proanthocyanidins. Other polyphenols were also present but in low quantity. The acetone extract of V. faba L. gave a good in vitro inhibition of yeasts and was the most active for treating candidiasis in mice. It decreased the percentage of mortality with only 20μg. But the in vivo antifungal activity of this extract on T. mentagrophytes was low. It only showed a small diminution of crusting and erythema after the administration of 100μg. On the contrary, the acetone extracts of P. granatum L. had a poor activity against yeasts and a better one against moulds. It gave the best in vivo antifungal activity against T. mentagrophytes by healing animals with 40μg. The extract of P. granatum L. gave also an interesting in vivo antifungal activity against T. mentagrophytes with an active dose of 80μg. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  14. Efeito antibacteriano e antiaderente in vitro do extrato da Punica granatum Linn. sobre microrganismos do biofilme dental

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    Jozinete V. Pereira

    Full Text Available Nesta pesquisa foi avaliada a atividade antimicrobiana e a capacidade de inibição da síntese de glucano in vitro do extrato da casca do fruto da romã (Punica granatum Linn. sobre linhagens bacterianas de Streptococcus mitis, Streptococcus mutans, Streptococcus sanguis, Streptococcus sobrinus e Lactobacillus casei. Os ensaios foram realizados pelas técnicas de ágar-difusão em placas para determinação da Concentração Inibitória Mínima (CIM e técnica dos tubos inclinados para determinação da Concentração Inibitória Mínima de Aderência (CIMA ao vidro, na presença de 5% de sacarose. Os mesmos procedimentos foram realizados com a clorexidina à 0,12%. As CIMs (mg/mL do extrato da P. granatum frente ao S. mitis, S. mutans, S. sanguis, S. sobrinus e L. casei foram 1:32, 1:8, 1:8, 1:512, e 1:128, respectivamente. Para as CIMAs o extrato da P. granatum mostrou resultados melhores que a clorexidina, exceto para o S. mutans com achados semelhantes na diluição de 1:256. Os resultados mostram a potencialidade da P. granatum na inibição do crescimento bacteriano e síntese de glucano representada pela aderência ao vidro, sugerindo o emprego do extrato da romã, como meio alternativo, no controle desses microrganismos na formação do biofilme.

  15. Pomegranate (Punica granatum) Seed Oil for Treating Menopausal Symptoms: An Individually Controlled Cohort Study.

    Science.gov (United States)

    Huber, Roman; Gminski, Richard; Tang, Tao; Weinert, Tomas; Schulz, Sabine; Linke-Cordes, Margareta; Martin, Ines; Fischer, Heide

    2017-03-01

    Context • In the folk medicine of Mediterranean countries and in ancient Ayurveda, Punica granatum seeds (ie, pomegranate seeds) have been used for treatment of various disorders, including those that nowadays are classified as menopausal symptoms (MSs). Pomegranate seed oil (PSO) from those seeds mainly contains unsaturated fatty acids such as γ-linoleic acid and linolenic acid, but it also includes phytoestrogens. It is, therefore, regarded as a promising option for treating MSs today. Objectives • The study intended to investigate the safety and effectiveness of PSO as a defined P granatum seed oil for patients with MSs. Design • The research team designed an individually controlled, investigator-initiated cohort study. Setting • The treatments were performed at 2 institutions: (1) the Center for Complementary Medicine at the University Medical Center Freiburg (Freiburg, Germany); and (2) in the medical practice of H. Fischer (Freiburg, Germany). Participants • Seventy-eight patients, who had a mean duration of MSs of 46 mo, participated in the study. Intervention • After 4 wk without treatment, which functioned as a period providing an individual control, each participant took 1000 mg of PSO daily in 2 capsules for 8 wk. Outcome Measures • The symptom severity was scored on the German version of the menopausal rating scale (MRS) at baseline, after 4 wk without treatment, after 4 wk of treatment, and postintervention, with 0 = absence of symptoms and 4 = very strong symptoms. The efficacy and tolerability were estimated on scales from 0-4. Each participant's 17ß estradiol was determined at baseline and after postintervention using the patient's sera. The content of the β-sitosterol was determined in the PSO preparations by gas chromatography. Results • The content of β-sitosterol in the PSO used in the study was 6.3 mg/1000 mg. In the intention to treat analysis, most MRS symptoms were significantly and relevantly reduced (eg, hot flushes

  16. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer.

    Science.gov (United States)

    Kim, Nam Deuk; Mehta, Rajendra; Yu, Weiping; Neeman, Ishak; Livney, Talia; Amichay, Akiva; Poirier, Donald; Nicholls, Paul; Kirby, Andrew; Jiang, Wenguo; Mansel, Robert; Ramachandran, Cheppail; Rabi, Thangaiyan; Kaplan, Boris; Lansky, Ephraim

    2002-02-01

    Fresh organically grown pomegranates (Punica granatum L.) of the Wonderful cultivar were processed into three components: fermented juice, aqueous pericarp extract and cold-pressed or supercritical CO2-extracted seed oil. Exposure to additional solvents yielded polyphenol-rich fractions ('polyphenols') from each of the three components. Their actions, and of the crude whole oil and crude fermented and unfermented juice concentrate, were assessed in vitro for possible chemopreventive or adjuvant therapeutic potential in human breast cancer. The ability to effect a blockade of endogenous active estrogen biosynthesis was shown by polyphenols from fermented juice, pericarp, and oil, which inhibited aromatase activity by 60-80%. Fermented juice and pericarp polyphenols, and whole seed oil, inhibited 17-beta-hydroxysteroid dehydrogenase Type 1 from 34 to 79%, at concentrations ranging from 100 to 1,000 microg/ml according to seed oil > fermented juice polyphenols > pericarp polyphenols. In a yeast estrogen screen (YES) lyophilized fresh pomegranate juice effected a 55% inhibition of the estrogenic activity of 17-beta-estradiol; whereas the lyophilized juice by itself displayed only minimal estrogenic action. Inhibition of cell lines by fermented juice and pericarp polyphenols was according to estrogen-dependent (MCF-7) > estrogen-independent (MB-MDA-231) > normal human breast epithelial cells (MCF-10A). In both MCF-7 and MB-MDA-231 cells, fermented pomegranate juice polyphenols consistently showed about twice the anti-proliferative effect as fresh pomegranate juice polyphenols. Pomegranate seed oil effected 90% inhibition of proliferation of MCF-7 at 100 microg/ml medium, 75% inhibition of invasion of MCF-7 across a Matrigel membrane at 10 microg/ml, and 54% apoptosis in MDA-MB-435 estrogen receptor negative metastatic human breast cancer cells at 50 microg/ml. In a murine mammary gland organ culture, fermented juice polyphenols effected 47% inhibition of cancerous

  17. Anti-coccidial, anthelmintic and antioxidant activities of pomegranate (Punica granatum) peel extract.

    Science.gov (United States)

    Dkhil, Mohammed A

    2013-07-01

    Coccidiosis and helminthosis in poultry are responsible for worldwide economic losses. The methanolic extract of Punica granatum (pomegranate) peel was used in vivo for its pharmacological, antioxidant and anti-coccidial properties and in vitro for its anthelmintic activity. For the in vivo study, four groups of mice were investigated. The first group was inoculated only with sterile saline and served as the control group. The second group was treated by oral gavage with pomegranate extract (300 mg/kg) daily for 5 days. The third and fourth groups were infected with 10(3) sporulated oocysts of Eimeria papillata. The fourth group was also treated once daily with pomegranate peel extract for 5 days. For the in vitro study, the anthelmintic effect of pomegranate peel extract was observed on live adult Allolobophora caliginosa. Paraffin sections from jejunum as well as jejunal homogenate were prepared for the histopathological and biochemical investigations, respectively. The data showed that mice infected with E. papillata revealed an output of approximately 2.9 × 10(5) oocysts per gram faeces on day 5 p.i. This output is significantly decreased to 50 % in pomegranate-treated mice. Infection with E. papillata induced marked histopathological alterations in jejunum in the form of inflammation, vacuolation of the epithelium and destruction of some villi. In addition, pomegranate extract caused a great diminish in body weight loss of infected mice. Moreover, the number of goblet cells stained with Alcian blue within the infected villi was significantly increased by about 26 % after pomegranate treatment. In addition, Pomegranate significantly lowered the increased number of apoptotic cells due to E. papillata infection by about 36 %. The results showed that E. papillata enhanced hydrogen peroxide, lipid peroxidation and nitric oxide production with concomitant reduction in glutathione. Pomegranate induced marked improvements in all of the studied parameters as well as

  18. A nematicidal tannin from Punica granatum L. rind and its physiological effect on pine wood nematode (Bursaphelenchus xylophilus).

    Science.gov (United States)

    Guo, Qunqun; Du, Guicai; Qi, Hongtao; Zhang, Yanan; Yue, Tongqing; Wang, Jingchao; Li, Ronggui

    2017-01-01

    The ethanol extract of Punica granatum L. rind was tested to show significant nematicidal activity against pine wood nematode. Three nematicidal compounds were obtained from the ethanol extract by bioassay-guided fractionation and identified as punicalagin 1, punicalin 2, and corilagin 3 by mass and nuclear magnetic resonance spectral data analysis. Punicalagin 1 was most active against PWN among the purified compounds with the LC 50 value of 307.08μM in 72h. According to the enzyme assays in vitro, punicalagin 1 could inhibit the activity of acetylcholinesterase, amylase and cellulase from PWN with IC 50 value of 0.60mM, 0.96mM and 1.24mM, respectively. The morphological structures of PWNs treated by punicalagin 1 were greatly changed. These physiological effects of punicalagin 1 on PWN may helpful to elucidate its nematicidal mechanism. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. EFEK ANTIBAKTERI EKSTRAK KULIT BUAH DELIMA (Punica granatum L. TERHADAP BAKTERI PENYEBAB DIARE SECARA IN VITRO DAN UJI TOKSISITAS AKUT

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    Dian Sundari

    2012-10-01

    Full Text Available Telah dilakukan Penelitian efek antibakteri ekstrak alkohol 70% kulit buah delima (Punica granatum L terhadap bakteri Salmonell typhi, Escherichia coli, Shigella dysenteriae dan Vibro cholerae secara in vitro. Pengujian dilakukan menggunakan metode difusi dengan cakram kertas. Sebagai pembanding positif digunakan klorafenikol dan tetrasiklin, sedangkan akuades sebagai pembanding negatif. Selain itu, untuk mengetahui keamanan bahan, dilakukan uji toksisitas akut (LD50-nya pada hewan coba mencit dengan cara Weil C.S.Dari hasil penelitian, diketahui ekstrak kulit buah delima mempunyai efek antibakteri, ini terlihat dari konsentrasi yang dicoba (8,6; 34,4; 137,6; mmg/ml terdapat zona (daerah bening bekas bakteri pada lempeng agar yang ditanami bakteri Salmonella typhi dan Vibrio cholerae. Makin besar dosis yang diberikan, makin besar bebas bakterinya. Dari uji toksisitas akut, ternyata bahan termasuk golongan Moderatel toxic.

  20. In vitro assessment of the antimicrobial effects of pomegranate (Punica granatum L. peel decoction on saliva samples

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    Solon José de Oliveira Leite

    2014-01-01

    Full Text Available Several products have been developed to eliminate or reduce potential pathogenic microorganisms of the oral microbiome. The continuous use of these synthetic products can result in side effects such as vomiting, diarrhea, darkening of the teeth and the induction of microbial resistance. Pomegranate (Punica granatum peel decoction was tested to assess its antimicrobial activity. In vitro analysis showed the decoction had antimicrobial activity against strains of Pseudomonas aeruginosa and Candida albicans, but none was detected against Enterococcus faecalis. When tested on saliva samples from children, the decoction showed great potential in reducing the load of microorganisms, the inhibition haloes produced with saliva samples being similar to those of the antimicrobial control (0.12% chlorhexidine. The pomegranate peel decoction in water could thus provide a promising source for developing solutions for use against oral diseases.

  1. Effect of Punica granatum fruit peel on glucose-6-phosphate dehydrogenase and malate dehydrogenase in amphistome Gastrothylax indicus.

    Science.gov (United States)

    Aggarwal, Rama; Bagai, Upma

    2017-03-01

    Increasing anthelmintic resistance and the impact of conventional anthelmintics on the environment, it is important to look for alternative strategies against helminth parasite in sheep. Important lipogenic enzymes like glucose-6-phosphate dehydrogenase (G-6-PDH) and malate dehydrogenase (MDH) show subcellular distribution pattern. Activity of G-6-PDH was largely restricted to cytosolic fraction while MDH was found in both cytosolic and mitochondrial fraction in Gastrothylax indicus. Following in vitro treatment with ethanolic and aqueous extracts of Punica granatum fruit peel and commercial anthelmintic, albendazole G-6-PDH activity was decreased by 19-32 %, whereas MDH was suppressed by 24-41 %, compared to the respective control. Albendazole was quite effective when compared with negative control and both the extracts. The results indicate that phytochemicals of plant may act as potential vermifuge or vermicide.

  2. The Investigation for Antifungal Effect of Medicinal Plants, Combination Infusion of Piper Bettle Leaves, Punica Granatum Fructus Cortec, Curcuma Domestica Rhizome

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    Berna Elya

    2002-12-01

    Full Text Available The tested demartophyta used Candida albicans. This research using dilution method to determine of minimum inhibitory concentration (MIC and difusion method to determine zone inhibition around of disc. The results of determination of MIC showed that combination infusion Piper bettle leaves with Punica granatum Fructus Cortex against C. albicans respectively, 31,2 mg/ml : 7,8 mg/ml; 15,6 mg/ml : 15,6 mg/ml and 7,8 mg/ml : 31,2 mg/ml. The determination for zone inhibition from 3 concentration of infusion of Piper bettle leaves with 3 concentration of Punica granatum Fructus Cortex with 9 combination against C. albicans showed that combination of two infusion is the larger than the single infusion.

  3. Down-Regulation of Glycosyl Transferase Genes in Streptococcus Mutans by Punica Granatum L. Flower and Rhus Coriaria L. Fruit Water Extracts.

    Science.gov (United States)

    Vahid-Dastjerdi, Elahe; Monadi, Elham; Khalighi, Hamid Reza; Torshabi, Maryam

    2016-01-01

    In our previous studies, we showed the inhibitory effects of Punica granatum L. flower and Rhus coriaria L. fruit water extracts on dental plaque accumulation by several bacteria, especially Streptococcus mutans (S. mutans), on orthodontic wire by in-vitro assays. In this study, the anti-cariogenic properties of the extracts were evaluated by assessing their effects on expression of glycosyltransferase (gtf) genes, which are responsible for initial biofilm formation by S. mutans. In this study, the effect of herbal extracts on expression of gtfB, C (encoding enzymes that produce water-insoluble glucans) and D (encoding enzymes that produce water-soluble glucans) genes in S. mutans growing in planktonic state was evaluated quantitatively by real-time polymerase chain reaction (PCR) method. The minimum biofilm inhibitory concentration (MBIC) of understudied herbal water extracts significantly suppressed gtfB, C and D gene expression by 85.3 ± 7.5%, 33.3 ± 6.4% and 25 ± 14%, respectively for Punica granatum L. extract and 73.4 ± 7.3%, 93.8 ± 2.7% and 59.3 ± 9.8%, respectively for Rhus coriaria L. extract compared to the non-treated control group (P gtfC and D was significantly greater (10.8 and 1.8 fold, respectively) than that of Punica granatum L. extract. These findings suggest that Punica granatum L. and especially Rhus coriaria L. maybe used as novel, natural antiplaque agents since they inhibit specific genes associated with bacterial biofilm formation without necessarily affecting the growth of oral bacteria.

  4. The effect of extract of Punica granatum var. pleniflora for treatment of minor recurrent aphthous stomatitis

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    Shahin Gavanji

    2014-06-01

    Conclusion: The water and alcoholic extracts of P. granatum varpleniflora decreased the entire time of complete treatment, and the treatment was meaningfully satisfactory for patients who participated in this experiment.

  5. Photoprotection by Punica granatum seed oil nanoemulsion entrapping polyphenol-rich ethyl acetate fraction against UVB-induced DNA damage in human keratinocyte (HaCaT) cell line

    OpenAIRE

    Baccarin, T.; Mitjans Arnal, Montserrat; Ramos López, David; Lemos-Senna,Elenara; Vinardell Martínez-Hidalgo, Ma. Pilar

    2015-01-01

    There has been an increase in the use of botanicals as skin photoprotective agents. Pomegranate (Punica granatum L.) is well known for its high concentration of polyphenolic compounds and for its antioxidant and anti-inflammatory properties. The aim of this study was to analyse the photoprotection provided by Punica granatum seed oil nanoemulsion entrapping the polyphenol-rich ethyl acetate fraction against UVB-induced DNA damage in the keratinocyte HaCaT cell line. For this purpose, HaCaT ce...

  6. The Effectiveness of Cinnamomum zeylanicum, Punica granatum Flower and Capsicum annuum Extracts Against Parascaris equorum Infective Larvae

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    Ehsan RAKHSHANDEHROO

    2016-07-01

    Full Text Available Recent investigations have shown that plants with medicinal peculiarities as good alternative to anthelmintics for livestock. In this study, the anthelmintic effects of three medicinal herbs (Cinnamomum zeylanicum, Punica granatum flower and Capsicum annuum were screened in vitro against the infective larvae of Parascaris equorum. The recovered larvae of the parasite were exposed to four concentrations (50, 75, 100 and 125 mg/mL of the extracts and then they examined for the viability at 0, 10, 20, 30 and 40 minutes after the challenge. The results revealed that all the concentrations of each plant extract had anthelmintic effects on P. equorum larvae. Also, the statistics indicated that there were significant interactions between the concentration of the extracts and time of exposure on the number of viable larvae. In addition, C. annuum extract seemed to be a strong potency to kill larvae at all concentrations from the beginning of the experiment. These results confirmed that those herbal extracts possess good antiparasitic effects against infective larvae of P. equorum and thus could be considered in anthelminth treatment strategies.

  7. Two UGT84 Family Glycosyltransferases Catalyze a Critical Reaction of Hydrolyzable Tannin Biosynthesis in Pomegranate (Punica granatum.

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    Nadia N Ono

    Full Text Available Hydrolyzable tannins (HTs play important roles in plant herbivore deterrence and promotion of human health. A critical step in HT production is the formation of 1-O-galloyl-β-D-glucopyranoside (β-glucogallin, ester-linked gallic acid and glucose by a UDP-glucosyltransferase (UGT activity. We cloned and biochemically characterized four candidate UGTs from pomegranate (Punica granatum, of which only UGT84A23 and UGT84A24 exhibited β-glucogallin forming activities in enzyme assays. Although overexpression and single RNAi knockdown pomegranate hairy root lines of UGT84A23 or UGT84A24 did not lead to obvious alterations in punicalagin (the prevalent HT in pomegranate accumulation, double knockdown lines of the two UGTs resulted in largely reduced levels of punicalagins and bis-hexahydroxydiphenyl glucose isomers. An unexpected accumulation of galloyl glucosides (ether-linked gallic acid and glucose was also detected in the double knockdown lines, suggesting that gallic acid was utilized by an unidentified UGT activity for glucoside formation. Transient expression in Nicotiana benthamiana leaves and immunogold labeling in roots of pomegranate seedlings collectively indicated cytosolic localization of UGT84A23 and UGT84A24. Overall, functional characterization and localization of UGT84A23 and UGT84A24 open up opportunities for further understanding the regulatory control of HT metabolism in plants and its coordination with other biochemical pathways in the metabolic network.

  8. HPLC Evaluation of Phenolic Profile, Nutritive Content, and Antioxidant Capacity of Extracts Obtained from Punica granatum Fruit Peel

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    Sushil Kumar Middha

    2013-01-01

    Full Text Available This study revealed polyphenolic content, nutritive content, antioxidant activity, and phenolic profile of methanol and aqueous extracts of Punica granatum peel extract. For this, extracts were screened for possible antioxidant activities by free radical scavenging activity (DPPH, hydrogen peroxide scavenging activity and ferric-reducing antioxidant power (FRAP assays. The total phenolics and flavonoid recovered by methanolic (MPE and the water extract (AQPE were ranged from 185 ± 12.45 to 298.00 ± 24.86 mg GAE (gallic acid equivalents/gm and 23.05 ± 1.54 to 49.8 ± 2.14 quercetin (QE mg/g, respectively. The EC50 of herbal extracts ranged from 100 µg/ml (0.38 quercetin equivalents, for AQPE, 168 µg/ml (0.80 quercetin equivalents, for MPE. The phenolic profile in the methanolic extracts was investigated by chromatographic (HPLC method. About 5 different flavonoids, phenolic acids, and their derivatives including quercetin (1, rutin (2, gallic acid (3, ellagic acid (4, and punicalagin as a major ellagitannin (5 have been identified. Among both extracts, methanolic extract was the most effective. This report may be the first to show nutritive content and correlation analysis to suggest that phenols and flavonoids might contribute the high antioxidant activity of this fruit peel and establish it as a valuable natural antioxidant source applicable in the health food industry.

  9. Rapid and Comprehensive Evaluation of (Polyphenolic Compounds in Pomegranate (Punica granatum L. Juice by UHPLC-MSn

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    Daniele Del Rio

    2012-12-01

    Full Text Available The comprehensive identification of phenolic compounds in food and beverages is a crucial starting point for assessing their biological, nutritional, and technological properties. Pomegranate (Punica granatum L. has been described as a rich source of (polyphenolic components, with a broad array of different structures (phenolic acids, flavonoids, and hydrolyzable tannins and a quick, high throughput, and accurate screening of its complete profile is still lacking. In the present work, a method for UHPLC separation and linear ion trap mass spectrometric (MSn characterization of pomegranate juice phenolic fraction was optimized by comparing several different analytical conditions. The best solutions for phenolic acids, anthocyanins, flavonoids, and ellagitannins have been delineated and more than 70 compounds have been identified and fully characterized in less than one hour total analysis time. Twenty-one compounds were tentatively detected for the first time in pomegranate juice. The proposed fingerprinting approach could be easily translated to other plant derived food extracts and beverages containing a wide array of phytochemical compounds.

  10. Two UGT84 Family Glycosyltransferases Catalyze a Critical Reaction of Hydrolyzable Tannin Biosynthesis in Pomegranate (Punica granatum).

    Science.gov (United States)

    Ono, Nadia N; Qin, Xiaoqiong; Wilson, Alexander E; Li, Gang; Tian, Li

    2016-01-01

    Hydrolyzable tannins (HTs) play important roles in plant herbivore deterrence and promotion of human health. A critical step in HT production is the formation of 1-O-galloyl-β-D-glucopyranoside (β-glucogallin, ester-linked gallic acid and glucose) by a UDP-glucosyltransferase (UGT) activity. We cloned and biochemically characterized four candidate UGTs from pomegranate (Punica granatum), of which only UGT84A23 and UGT84A24 exhibited β-glucogallin forming activities in enzyme assays. Although overexpression and single RNAi knockdown pomegranate hairy root lines of UGT84A23 or UGT84A24 did not lead to obvious alterations in punicalagin (the prevalent HT in pomegranate) accumulation, double knockdown lines of the two UGTs resulted in largely reduced levels of punicalagins and bis-hexahydroxydiphenyl glucose isomers. An unexpected accumulation of galloyl glucosides (ether-linked gallic acid and glucose) was also detected in the double knockdown lines, suggesting that gallic acid was utilized by an unidentified UGT activity for glucoside formation. Transient expression in Nicotiana benthamiana leaves and immunogold labeling in roots of pomegranate seedlings collectively indicated cytosolic localization of UGT84A23 and UGT84A24. Overall, functional characterization and localization of UGT84A23 and UGT84A24 open up opportunities for further understanding the regulatory control of HT metabolism in plants and its coordination with other biochemical pathways in the metabolic network.

  11. Specific phenolic compounds and sensory properties of a new dealcoholized red wine with pomegranate (Punica granatum L.) extract.

    Science.gov (United States)

    Tárrega, Maria Amparo; Varela, Paula; Fromentin, Emilie; Feuillère, Nicolas; Issaly, Nicolas; Roller, Marc; Sanz-Buenhombre, Marisa; Villanueva, Sonia; Moro, Carlos; Guadarrama, Alberto; Fiszman, Susana

    2014-09-01

    The pomegranate (Punica granatum L.) fruit has a long history of human consumption and possesses notable antioxidant and cardiovascular properties. This work evaluated the feasibility to provide a new functional beverage based on a dealcoholized red wine matrix supplemented by a pomegranate extract. The potential bioactive compounds in the pomegranate extract, punicalagin A and B and ellagic acid, were analyzed during the downstream process in order to evaluate the functional dose in the final beverage. The addition of pomegranate extract to the dealcoholized red wine resulted in a product with more intense yeast odor, acidity, yeast flavor, and astringency and with a less intense berry flavor. Consumer acceptance of the product was also investigated and the results revealed the existence of a niche of consumers willing to consume dealcoholized wine enriched with pomegranate extract. After tasting, 50% and 40% of those consumers initially interested by this product concept declared to be interested to purchase the control sample and the functional beverage, respectively. The daily consumption of two servings of 250 mL of this new pomegranate-enriched dealcoholized wine provides 82 mg of total ellagitannins, corresponding to the sum of punicalagin A and B and ellagic acid. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  12. Ellagitannins of the fruit rind of pomegranate (Punica granatum antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria

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    Bhattacharya Deepak

    2010-07-01

    Full Text Available Abstract Background The sun-dried rind of the immature fruit of pomegranate (Punica granatum is presently used as a herbal formulation (OMARIA, Orissa Malaria Research Indigenous Attempt in Orissa, India, for the therapy and prophylaxis of malaria. The pathogenesis of cerebral malaria, a complication of the infection by Plasmodium falciparum, is an inflammatory cytokine-driven disease associated to an up-regulation and activity of metalloproteinase-9 and to the increase of TNF production. The in vitro anti-plasmodial activity of Punica granatum (Pg was recently described. The aim of the present study was to explore whether the anti-malarial effect of OMARIA could also be sustained via other mechanisms among those associated to the host immune response. Methods From the methanolic extract of the fruit rind, a fraction enriched in tannins (Pg-FET was prepared. MMP-9 secretion and expression were evaluated in THP-1 cells stimulated with haemozoin or TNF. The assays were conducted in the presence of the Pg-FET and its chemical constituents ellagic acid and punicalagin. The effect of urolithins, the ellagitannin metabolites formed by human intestinal microflora, was also investigated. Results Pg-FET and its constituents inhibited the secretion of MMP-9 induced by haemozoin or TNF. The effect occurred at transcriptional level since MMP-9 mRNA levels were lower in the presence of the tested compounds. Urolithins as well inhibited MMP-9 secretion and expression. Pg-FET and pure compounds also inhibited MMP-9 promoter activity and NF-kB-driven transcription. Conclusions The beneficial effect of the fruit rind of Punica granatum for the treatment of malarial disease may be attributed to the anti-parasitic activity and the inhibition of the pro-inflammatory mechanisms involved in the onset of cerebral malaria.

  13. Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria

    Science.gov (United States)

    2010-01-01

    Background The sun-dried rind of the immature fruit of pomegranate (Punica granatum) is presently used as a herbal formulation (OMARIA, Orissa Malaria Research Indigenous Attempt) in Orissa, India, for the therapy and prophylaxis of malaria. The pathogenesis of cerebral malaria, a complication of the infection by Plasmodium falciparum, is an inflammatory cytokine-driven disease associated to an up-regulation and activity of metalloproteinase-9 and to the increase of TNF production. The in vitro anti-plasmodial activity of Punica granatum (Pg) was recently described. The aim of the present study was to explore whether the anti-malarial effect of OMARIA could also be sustained via other mechanisms among those associated to the host immune response. Methods From the methanolic extract of the fruit rind, a fraction enriched in tannins (Pg-FET) was prepared. MMP-9 secretion and expression were evaluated in THP-1 cells stimulated with haemozoin or TNF. The assays were conducted in the presence of the Pg-FET and its chemical constituents ellagic acid and punicalagin. The effect of urolithins, the ellagitannin metabolites formed by human intestinal microflora, was also investigated. Results Pg-FET and its constituents inhibited the secretion of MMP-9 induced by haemozoin or TNF. The effect occurred at transcriptional level since MMP-9 mRNA levels were lower in the presence of the tested compounds. Urolithins as well inhibited MMP-9 secretion and expression. Pg-FET and pure compounds also inhibited MMP-9 promoter activity and NF-kB-driven transcription. Conclusions The beneficial effect of the fruit rind of Punica granatum for the treatment of malarial disease may be attributed to the anti-parasitic activity and the inhibition of the pro-inflammatory mechanisms involved in the onset of cerebral malaria. PMID:20642847

  14. LC-DAD-ESI/MS(n) determination of direct condensation flavanol-anthocyanin adducts in pressure extracted pomegranate (Punica granatum L.) juice.

    Science.gov (United States)

    Sentandreu, Enrique; Navarro, Jose L; Sendra, Jose M

    2010-10-13

    Pomegranate (Punica granatum L.) juice, obtained by pressure extraction of the whole fruit, has been analyzed for its flavanol-anthocyanin adduct content using reversed-phase liquid chromatography with diode array detection, coupled to mass spectrometry (ion trap) with electrospray ionization (HPLC-DAD-ESI/MS(n)), operating in positive ion mode. A total of 35 dimers have been detected, consisting of mono- and disubstituted hexoside derivatives of the adducts between the flavan-3-ols (epi)gallocatechin, (epi)catechin and (epi)afzelechin and the anthocyanidins delphinidin, cyanidin and pelargonidin. In addition, evidence is given for the presence of additional anthocyanin-flavanol adducts in this juice.

  15. Fatty acid, vitamin E and sterols composition of seed oils from nine different pomegranate (Punica granatum L.) cultivars grown in Spain

    OpenAIRE

    Fernandes, Luana; PEREIRA, J. A.; Lopéz-Cortés, Isabel; Salazar, Domingo M.; Ramalhosa, Elsa; Casal, Susana

    2015-01-01

    The present study was conducted to determine the major bioactive lipid components of the seed oils of nine pomegranate (Punica granatum L.) cultivars grown in Spain, namely fatty acids, vitamin E and sterol compositions. The seeds yielded oil contents ranging from 4.44% to 13.70% of dry matter and showed high contents of polyunsaturated fatty acids (86.7–90.3%). The predominant fatty acid was 9,11,13-octadeca-trienoic acid (punicic acid), a conjugated linolenic acid characteristic from pom...

  16. Potential Anti-Inflammatory Effects of the Hydrophilic Fraction of Pomegranate (Punica granatum L.) Seed Oil on Breast Cancer Cell Lines

    OpenAIRE

    Susan Costantini; Fabiola Rusolo; Valentina De Vito; Stefania Moccia; Gianluca Picariello; Francesca Capone; Eliana Guerriero; Giuseppe Castello; Maria Grazia Volpe

    2014-01-01

    In this work, we characterized conjugated linolenic acids (e.g., punicic acid) as the major components of the hydrophilic fraction (80% aqueous methanol extract) from pomegranate (Punica granatum L.) seed oil (PSO) and evaluated their anti-inflammatory potential on some human colon (HT29 and HCT116), liver (HepG2 and Huh7), breast (MCF-7 and MDA-MB-231) and prostate (DU145) cancer lines. Our results demonstrated that punicic acid and its congeners induce a significant decrease of cell viabili...

  17. Efek ekstrak buah delima (Punica Granatum L) terhadap ekspresi wild p53 pada sel ganas rongga mulut mencit strain swiss webster

    OpenAIRE

    Hernawati, Sri; Rantam, Fedik Abdul; Sudiana, I Ketut; Rahayu, Retno Pudji

    2013-01-01

    Background: Squamous cell carcinoma is the most common cancer in the oral cavity. DNA tests showed that almost 90% of cases revealed wild p53 gene mutations. Wild p53 gene mutations cause p53 inactivation so the cell cycle does not stop in G1 phase but continues to S phase and G2 and M, it makes the mutated DNA remains multiplied and apoptosis does not occur. One candidate of the cancer treatment alternatives is pomegranate extract (Punica granatum L – PGL). Purpose: The purpose of study was ...

  18. Avaliação da atividade antioxidante em diferentes extratos da polpa e sementes da romã (Punica granatum, L. Antioxidant activity evaluation of different polarities extracts by pulp and seeds of pomegranate (Punica granatum, L.

    Directory of Open Access Journals (Sweden)

    Fernanda Archilla Jardini

    2007-03-01

    Full Text Available Avaliou-se a atividade antioxidante dos extratos etéreo, alcoólico e aquoso obtidos da polpa e das sementes da romã (Punica granatum, L., utilizando-se dois sistemas: 1 co-oxidação do beta-caroteno/ácido linoléico e 2 Rancimat®. Inicialmente foram determinados os compostos redutores presentes na polpa (1.214 mg/100 g e nas sementes (1.732 mg/100 g e, em seqüência, avaliou-se nos extratos, através de cromatografia em camada delgada (CCD, a presença de compostos fenólicos com atividade antioxidante. Os extratos aquosos tanto da polpa quanto das sementes apresentaram as maiores porcentagens de inibição da oxidação: 87,31% e 93,08%, respectivamente. Através da avaliação cinética pelo teste de co-oxidação com beta-caroteno e ácido linoléico, pôde-se verificar que a alta porcentagem da atividade antioxidante dos extratos aquosos é devida à capacidade de inibir a oxidação nas fases inicial e mais avançada do processo oxidativo, agindo por mecanismos primário e secundário. Todos os extratos (etéreo, alcoólico e aquoso apresentaram elevada capacidade em prolongar o período de indução da oxidação, medida pelo aparelho Rancimat®, sendo, ainda, significativamente (pIn etheric, alcoholic and aqueous extracts obtained from pomegranate (Punica granatum, L. pulp and seeds their antioxidant activity was evaluated by using two systems: co-oxidation of beta-carotene/linoleic acid and 2 Rancimat®. First of all, the presence of reducing compounds was detected in the pulp (1,214 mg/100 g and in the seeds (1,732 mg/100 g. The phenolic compounds with antioxidant activity were then evaluated in the extracts using thin-layer chromatography (TLC. The aqueous extracts from the pulp and the seeds showed the highest antioxidant activity of 87.31% and of 93.08%, respectively. The kinetic curves obtained by cooxidation of beta-carotene and linoleic acid substrates also showed the highest values in the aqueous. These results were

  19. Preventive Effect of Three Pomegranate (Punica granatum L.) Seeds Fractions on Cerulein-Induced Acute Pancreatitis in Mice.

    Science.gov (United States)

    Minaiyan, Mohsen; Zolfaghari, Behzd; Taheri, Diana; Gomarian, Mahdi

    2014-04-01

    Acute pancreatitis (AP) refers to afflicted inflammation of pancreas with unfavorable adverse effects and developed multiple organ failures. Unfortunately, there is not a certain therapeutic method for this disease. Oxidative stress has a serious role in the pathogenesis of AP. Thus, decreasing of oxidative stress may prevent induction and progression of AP. Punica granatum L. has been extensively used in traditional medicine and possesses various active biological elements. Due to antioxidant and anti-inflammatory properties of pomegranate, it could be considered as a good candidate alternative medicine with beneficial effects on AP. In this study, we decided to study the protective effect of three fractions of pomegranate seeds on cerulein-induced AP. AP was induced in male Syrian mice by five intraperitoneal (i.p.) injection of cerulein (50 μg/kg) with 1 h intervals. Treatments with pomegranate freeze-dried powder (PFDP) and hydroalcoholic pomegranate seeds extract (PSE) at doses of 125, 250, 500 mg/kg (i.p.) were started 30 min before pancreatitis induction. Pomegranate seed oil fraction (PSOF) was orally administered (50, 100, 200 μL/kg) and continued for 10 days. Pancreatic tissue was evaluated for histopathological parameters and pancreatic myeloperoxidase (MPO) activity as well as lipase and amylase levels were measured in plasma. The higher doses of three fractions (250 and 500 mg/kg for PFDP and PSE and doses of 100, 200 μL/kg for PSOF) significantly reduced amylase and lipase activity in serum (at least P seeds fractions can prevent and/or treat the AP.

  20. Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry.

    Science.gov (United States)

    van Elswijk, Danny A; Schobel, Uwe P; Lansky, Ephraim P; Irth, Hubertus; van der Greef, Jan

    2004-01-01

    During recent years, phytoestrogens have been receiving an increasing amount of interest, as several lines of evidence suggest a possible role in preventing a range of diseases, including the hormonally dependent cancers. In this context, various parts of the pomegranate fruit (Punica granatum; Punicaceae), e.g. seed oil, juice, fermented juice and peel extract, have been shown to exert suppressive effects on human breast cancer cells in vitro. On-line biochemical detection coupled to mass spectrometry (LC-BCD-MS) was applied to rapidly profile the estrogenic activity in the pomegranate peel extract. The crude mixture was separated by HPLC, after which the presence of biologically active compounds, known or unknown, was detected by means of an on-line beta-estrogen receptor (ER) bioassay. Chemical information, such as molecular weight and MS/MS fingerprint, was obtained in real time by directing part of the HPLC effluent towards a mass spectrometer. Using this approach in total three estrogenic compounds, i.e. luteolin, quercetin and kaempferol, were detected and identified by comparing the obtained molecular weights and negative ion APCI MS/MS spectra with the data of an estrogenic compound library. Although well known in literature and widely distributed in nature, the presence of these phytoestrogenic compounds in pomegranate peel extract was not reported previously. Compared to traditional screening approaches of complex mixtures, often characterized by a repeating cycle of HPLC fractionation and biological screening, LC-BCD-MS was shown to profoundly accelerate the time required for compound description and identification.

  1. Functional Analysis of a Pomegranate (Punica granatum L.) MYB Transcription Factor Involved in the Regulation of Anthocyanin Biosynthesis.

    Science.gov (United States)

    Khaksar, Ghazale; Sayed Tabatabaei, Badraldin Ebrahim; Arzani, Ahmad; Ghobadi, Cyrus; Ebrahimie, Esmaeil

    2015-03-01

    Pomegranate fruit (Punica granatum L.) is a rich source of anthocyanin pigments resulting in vibrant colours and anti-oxidant contents. Although the intensity and pattern of anthocyanin biosynthesis in fruit are strongly influenced by R2R3-MYB transcription factors, little is known about the regulation and role of MYB in anthocyanin pathway of pomegranate. The present study was conducted to elucidate the relationship between the expression of MYB transcription factor and the anthocyanin accumulation during the colour development phase of pomegranate fruits. In this work, R2R3-MYB transcription factor (PgMYB) was isolated and characterized from pomegranate skin through RACE-PCR. The expression of PgMYB gene was monitored in three distinct pomegranate accessions with distinctive skin colour and pattern by semi-quantitative RT-PCR. The results indicated a strong association between skin colour in mature pomegranate fruits with the PgMYB transcripts. The highest expression level of PgMYB gene was observed in Poost Siyah Yazd (dark purple skin) throughout the ripening process. Furthermore, comparison of PgMYB amino acid sequences with those of R2R3-MYB family in grapevine, eucalyptus, peach, cacao, populus and Arabidopsis demonstrated that this protein shares high similarity (75-85% amino acid identity) with their conserved MYB domain. Computational structure prediction of PgMYB showed that the three conserved amino acids (Asn, Lys and Lys) are present in the same position of the MYB domain. It is speculated that PgMYB gene influences the fruit colour and could be used to improve the accumula-tion of anthocyanin pigments in the pomegranate fruit.

  2. Characterization of Punica granatum L. peels and quantitatively determination of its biosorption behavior towards lead(II) ions and Acid Blue 40.

    Science.gov (United States)

    Ay, Ciğdem Omeroğlu; Ozcan, A Safa; Erdoğan, Yunus; Ozcan, Adnan

    2012-12-01

    In this study, a waste biomass of Punica granatum L. (P. granatum L.) peels was firstly characterized by means of Brunauer-Emmett-Teller (BET) surface area, elemental analysis, FT-IR, thermogravimetric (TG) analysis and zeta potential measurement techniques. FT-IR results indicated that the mechanism involved in the biosorption of lead(II) ions and AB40 onto biosorbent was mainly attributed to lead(II) ions and dye binding of amino, carboxylic, hydroxyl and carbonyl groups. The biosorption abilities of P. granatum L. peels for lead(II) ions and Acid Blue 40 (AB40) were then investigated. Biosorption equilibrium and kinetic data fit well by the Langmuir isotherm and the pseudo-second-order kinetic models, respectively. The maximum biosorption capacities were 193.9 mg g(-1) for lead(II) ions and 138.1 mg g(-1) for AB40. Biosorption processes were spontaneous and endothermic in nature according to the thermodynamic results and the equilibrium was attained within 50 min. The validity of used kinetic models in this study can be quantitatively checked by using a normalized standard deviation Δq(%). Finally, the biosorption procedure was adopted to treat the real and simulated wastewaters including several metal salts and dyes. The wastewater applications have shown that the biosorbent indicated a reasonable biosorption capability to remove lead(II) ions (98.07%) and AB40 (94.76%) from industrial wastewaters. Copyright © 2012 Elsevier B.V. All rights reserved.

  3. Effects of anti-lipid peroxidation of Punica granatum fruit extract in endothelial cells induced by plasma of severe pre-eclamptic patients

    Directory of Open Access Journals (Sweden)

    Isri Nasifah

    2017-10-01

    Full Text Available Preeclampsia is a pregnancy disorder characterized by hypertension and proteinuria. This disorder involves oxidative stress and changes in endothelial homeostasis. This study was aimed to seek whether an ethanolic extract of Punica granatum fruit inhibits 8-iso-PGFα formation and modulates nitric oxide (NO in endothelial cells induced by plasma from pre-eclamptic patients. Endothelial cells were cultured from human umbilical vein endothelial cells. At confluence, endothelial cells were divided into five groups, which included endothelial cells exposed to 2% plasma from normal pregnancy (NP, endothelial cells exposed to 2% plasma from pre-eclamptic patients (PP, endothelial cells exposed to PP in the presence of ethanolic extract of P. granatum (PP+PG at the following three doses: 14; 28; and 56 ppm. Analysis of 8-iso-PGFα was done by immunoassay technique. Analysis of NO level was done by colorimetric technique. Plasma from PP significantly increased 8-iso-PGFα level compared to cells treated by normal pregnancy plasma. This increase in 8-iso-PGFα was significantly (p0.05 between groups. P. granatum fruit extract protects endothelial cells from oxidative stress induced by plasma from pre-eclamptic patients.

  4. Spontaneous ultra fast synthesis of gold nanoparticles using Punica granatum for cancer targeted drug delivery.

    Science.gov (United States)

    Ganeshkumar, Moorthy; Sathishkumar, Muniram; Ponrasu, Thangavel; Dinesh, Murugan Girija; Suguna, Lonchin

    2013-06-01

    Rapid synthesis of mono-dispersed gold nanoparticles through economically feasible green chemistry approach is highly desirable. In this study, we have developed a method to synthesize mono-dispersed gold nanoparticles (PAuNPs) by mixing gold solution with fruit peel extract of Punica granutum without using any surfactant or external energy. In this method, physiologically stable, biocompatible PAuNPs were formed within 60s. Casein, being a biocompatible polymer, is used to couple the prepared PAuNPs for functionalization of folic acid, which is highly expressed in cancer cells. These functionalized PAuNPs could be used for targeted drug delivery for cancer with enhanced therapeutic efficacy and minimal side effects. PAuNPs were characterized by UV, IR, TEM, Particle size analyzer and zeta potential measurement. In vitro stability of the PAuNPs was also analyzed. Hemocompatibility of PAuNPs was evaluated in human blood samples and found that the particles were hemocompatible. The toxicity of the PAuNPs, 5-Fu and 5Fu@PAuNPs was analyzed in zebrafish embryos. The in vitro cytotoxicity of free 5-Fu, 5Fu@PAuNPs-Fa was investigated against MCF-7 cells (breast cancer) and observed that the amount of 5-Fu required to achieve 50% of growth of inhibition (Ic50) was much lower when compared to free 5-Fu. Copyright © 2013 Elsevier B.V. All rights reserved.

  5. A Traditional Mouthwash (Punica granatum var pleniflora) for Controlling Gingivitis of Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial.

    Science.gov (United States)

    Sedigh-Rahimabadi, Massih; Fani, Mohammadmehdi; Rostami-Chijan, Mahsa; Zarshenas, Mohammad M; Shams, Mesbah

    2017-01-01

    This study evaluates the safety and efficacy of Punica granatum var pleniflora mouthwash in treatment of diabetic gingivitis. In a double-blind randomized clinical trial 80 patients with diabetes mellitus and gingivitis were assigned to Golnaar and chlorhexidine 0.2% groups. After using mouthwashes for 2 weeks; participants underwent tooth scaling and the last visit was 2 weeks after scaling. The primary outcome measures were plaque, modified gingival and gingival bleeding indices, and pocket depth. Both interventions had significant improvement on all of the gingival and plaque indices (P gingival index for which Golnaar mouthwash had a superiority after 2 weeks when comparing with chlorhexidine (P = .039). Meanwhile, Golnaar mouthwash had no staining effect. Golnaar mouthwash is safe and effective in treatment of gingivitis in diabetic patients although further studies are recommended. © The Author(s) 2016.

  6. Green approach to corrosion inhibition of mild steel in two acidic solutions by the extract of Punica granatum peel and main constituents

    Energy Technology Data Exchange (ETDEWEB)

    Behpour, M., E-mail: m.behpour@kashanu.ac.ir [Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. 87317-51167 (Iran, Islamic Republic of); Ghoreishi, S.M.; Khayatkashani, M. [Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. 87317-51167 (Iran, Islamic Republic of); Soltani, N. [Department of Chemistry, Payame Noor University (PNU), 19395-4697 Tehran (Iran, Islamic Republic of)

    2012-01-05

    Graphical abstract: Ellagic acid (EA) and tannic acid (TA) were studied as corrosion inhibitors. The electron density HOMO and LUMO of EA and TA were used to explain difference in behavior of them. Highlights: Black-Right-Pointing-Pointer The extract of Punica granatum (PG) and their main constituent (ellagic acid (EA)) are found to be good inhibitors for the corrosion of mild steel in 1 M H{sub 2}SO{sub 4} and 2 M HCl. Black-Right-Pointing-Pointer The electrochemical inhibitive mechanism is explained by potentiodynamic polarization curves and electrochemical impedance spectroscopy (EIS) results. Black-Right-Pointing-Pointer The adsorption of ALLOX on mild steel surface was found to accord with the Temkin adsorption isotherm. Black-Right-Pointing-Pointer The effect of temperature on the corrosion behavior of mild steel in 2 M HCl and 1 M H{sub 2}SO{sub 4} without and with the PG extract was studied. - Abstract: The effect of the extract of Punica granatum (PG) and their main constituents involve ellagic acid (EA) and tannic acid (TA), as mild steel corrosion inhibitor in 2 M HCl and 1 M H{sub 2}SO{sub 4} solutions was investigated by weight loss measurements. The results obtained from the weight loss measurements show that the inhibition efficiency of TA even in high concentration is very low. Thus, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) investigations were used for different concentrations of PG and EA and best concentration of TA. Potentiodynamic polarization curves indicated that PG and EA behave as mixed-type inhibitors. EIS measurements show an increase of the transfer resistance with increasing inhibitor concentration. The temperature effect on the corrosion behavior of steel without and with the PG extract was studied. The inhibition action of the extract was discussed in view of Langmuir adsorption isotherm.

  7. Estudos com o extrato da Punica granatum Linn. (romã: efeito antimicrobiano in vitro e avaliação clínica de um dentifrício sobre microrganismos do biofilme dental = Studies with the extract of the punica granatum linn. (pomegranate: effect antimicrobial “in vitro” and trial avaliation of a toothpaste upon microrganisms of the oral biofilm

    Directory of Open Access Journals (Sweden)

    Pereira, Jozinete Vieira

    2005-01-01

    Full Text Available A atividade antimicrobiana in vitro, CIM (Concentração Inibitória Mínima, CIMA (Concentração Inibitória Mínima de Aderência e a CBM (Concentração Mínima Bactericida do extrato da romã (Punica granatum Linn. foi avaliada em cinco linhagens bacterianas do biofilme dental: Streptococcus mutans, Streptococcus mitis, Streptococcus sanguis, Streptococcus sobrinus e Lactobacillus casei. Em estudo comparativo com o gluconato de clorexidina, os resultados demonstraram efetiva ação inibitória de ambas as substâncias. O extrato da romã foi efetivo na CIMA das cinco linhagens ensaiadas, representada pela ausência de aderência ao vidro na presença de sacarose. A atividade antimicrobiana in vivo do extrato da romã foi testada em 13 pacientes, através do uso de um dentrifício a base desse extrato e foi observadas redução do número de Streptococcus mutans (53,84% e Índice de Sangramento Gengival. Conclui-se, portanto, que o extrato da Punica granatum Linn. , apresentou potente atividade antimicrobiana in vivo e in vitro sobre as linhagens do biofilme dental. Os resultados sugerem a utilização do extrato da romã em indicações terapêuticas na prática odontológica

  8. Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract.

    Science.gov (United States)

    Bogdan, Cătălina; Iurian, Sonia; Tomuta, Ioan; Moldovan, Mirela

    2017-01-01

    Striae distensae are a frequent skin condition associated with pregnancy, weight change or lack of skin elasticity. The aim of this research was to obtain a topical product containing herbal active ingredients with documented antioxidant and anti-inflammatory activity (Punica granatum seed oil and Croton lechleri resin extract) and demonstrate its positive effect on prevention and treatment of striae distensae. First, the cream base formulation was optimized through experimental design. Secondly, the cream containing the two active ingredients was investigated in an interventional nonrandomized clinical trial. The clinical outcome was assessed through biophysical parameters and ultrasonographic evaluation. The state of the skin was evaluated by biophysical measurements and ultrasonography at the beginning of the study and after 3 and 6 weeks. The experimental design was successfully used to set the best ranges for the technological and formulation factors to obtain a cosmetic formulation with optimal characteristics. The study of clinical efficacy on the optimal formulation revealed an increase in the dermis thickness, hydration and elasticity values in both groups after 6 weeks of cream application. The new oil-in-water cream containing P. granatum seed oil and C. lechleri resin extract can be helpful in the prevention or improving of skin changes associated with striae.

  9. Combined transgenic expression of Punica granatum conjugase (FADX) and FAD2 desaturase in high linoleic acid Arabidopsis thaliana mutant leads to increased accumulation of punicic acid.

    Science.gov (United States)

    Mietkiewska, Elzbieta; Miles, Robin; Wickramarathna, Aruna; Sahibollah, Ariff Firman; Greer, Michael S; Chen, Guanqun; Weselake, Randall J

    2014-09-01

    Arabidopsis was engineered to produce 21.2 % punicic acid in the seed oil. Possible molecular factors limiting further accumulation of the conjugated fatty acid were investigated. Punicic acid (18:3Δ(9cis,11trans,13cis) ) is a conjugated linolenic acid isomer and is a main component of Punica granatum (pomegranate) seed oil. Medical studies have shown that punicic acid is a nutraceutical with anti-cancer and anti-obesity properties. It has been previously demonstrated that the conjugated double bonds in punicic acid are produced via the catalytic action of fatty acid conjugase (FADX), which is a homolog of the oleate desaturase. This enzyme catalyzes the conversion of the Δ(12)-double bond of linoleic acid (18:2Δ(9cis,12cis) ) into conjugated Δ(11trans) and Δ(13cis) -double bonds. Previous attempts to produce punicic acid in transgenic Arabidopsis thaliana seeds overexpressing P. granatum FADX resulted in a limited accumulation of punicic acid of up to 4.4 %, accompanied by increased accumulation of oleic acid (18:1∆(9cis) ), suggesting that production of punicic acid in some way inhibits the activity of oleate desaturase (Iwabuchi et al. 2003). In the current study, we applied a new strategy to enhance the production of punicic acid in a high linoleic acid A. thaliana fad3/fae1 mutant background using the combined expression of P. granatum FADX and FAD2. This approach led to the accumulation of punicic acid at the level of 21 % of total fatty acids and restored the natural proportion of oleic acid observed in the A. thaliana fad3/fae1 mutant. In addition, we provide new insights into the high oleate phenotype and describe factors limiting the production of punicic acid in genetically engineered plants.

  10. De novo transcriptome assembly and quantification reveal differentially expressed genes between soft-seed and hard-seed pomegranate (Punica granatum L..

    Directory of Open Access Journals (Sweden)

    Hui Xue

    Full Text Available Pomegranate (Punica granatum L. belongs to Punicaceae, and is valued for its social, ecological, economic, and aesthetic values, as well as more recently for its health benefits. The 'Tunisia' variety has softer seeds and big arils that are easily swallowed. It is a widely popular fruit; however, the molecular mechanisms of the formation of hard and soft seeds is not yet clear. We conducted a de novo assembly of the seed transcriptome in P. granatum L. and revealed differential gene expression between the soft-seed and hard-seed pomegranate varieties. A total of 35.1 Gb of data were acquired in this study, including 280,881,106 raw reads. Additionally, de novo transcriptome assembly generated 132,287 transcripts and 105,743 representative unigenes; approximately 13,805 unigenes (37.7% were longer than 1,000 bp. Using bioinformatics annotation libraries, a total of 76,806 unigenes were annotated and, among the high-quality reads, 72.63% had at least one significant match to an existing gene model. Gene expression and differentially expressed genes were analyzed. The seed formation of the two pomegranate cultivars involves lignin biosynthesis and metabolism, including some genes encoding laccase and peroxidase, WRKY, MYB, and NAC transcription factors. In the hard-seed pomegranate, lignin-related genes and cellulose synthesis-related genes were highly expressed; in soft-seed pomegranates, expression of genes related to flavonoids and programmed cell death was slightly higher. We validated selection of the identified genes using qRT-PCR. This is the first transcriptome analysis of P. granatum L. This transcription sequencing greatly enriched the pomegranate molecular database, and the high-quality SSRs generated in this study will aid the gene cloning from pomegranate in the future. It provides important insights into the molecular mechanisms underlying the formation of soft seeds in pomegranate.

  11. De novo transcriptome assembly and quantification reveal differentially expressed genes between soft-seed and hard-seed pomegranate (Punica granatum L.).

    Science.gov (United States)

    Xue, Hui; Cao, Shangyin; Li, Haoxian; Zhang, Jie; Niu, Juan; Chen, Lina; Zhang, Fuhong; Zhao, Diguang

    2017-01-01

    Pomegranate (Punica granatum L.) belongs to Punicaceae, and is valued for its social, ecological, economic, and aesthetic values, as well as more recently for its health benefits. The 'Tunisia' variety has softer seeds and big arils that are easily swallowed. It is a widely popular fruit; however, the molecular mechanisms of the formation of hard and soft seeds is not yet clear. We conducted a de novo assembly of the seed transcriptome in P. granatum L. and revealed differential gene expression between the soft-seed and hard-seed pomegranate varieties. A total of 35.1 Gb of data were acquired in this study, including 280,881,106 raw reads. Additionally, de novo transcriptome assembly generated 132,287 transcripts and 105,743 representative unigenes; approximately 13,805 unigenes (37.7%) were longer than 1,000 bp. Using bioinformatics annotation libraries, a total of 76,806 unigenes were annotated and, among the high-quality reads, 72.63% had at least one significant match to an existing gene model. Gene expression and differentially expressed genes were analyzed. The seed formation of the two pomegranate cultivars involves lignin biosynthesis and metabolism, including some genes encoding laccase and peroxidase, WRKY, MYB, and NAC transcription factors. In the hard-seed pomegranate, lignin-related genes and cellulose synthesis-related genes were highly expressed; in soft-seed pomegranates, expression of genes related to flavonoids and programmed cell death was slightly higher. We validated selection of the identified genes using qRT-PCR. This is the first transcriptome analysis of P. granatum L. This transcription sequencing greatly enriched the pomegranate molecular database, and the high-quality SSRs generated in this study will aid the gene cloning from pomegranate in the future. It provides important insights into the molecular mechanisms underlying the formation of soft seeds in pomegranate.

  12. Germinação de sementes de romäzeiras (Punica granatum L. de acordo com a concentração de giberelina

    Directory of Open Access Journals (Sweden)

    William Takata

    2014-03-01

    Full Text Available A romäzeira (Punica granatum L. é fruteira de porte arbustivo, utilizada geralmente como planta ornamental e explorada quanto a suas características medicinais. Seus frutos apresentam cavidades internas onde estäo alojadas numerosas sementes e sem a presença de endosperma. Estas sementes apresentam certa dificuldade para germinar, sendo que se conseguiu atingir porcentagens satisfatórias de germinação com a utilização de estratificação, que é processo necessário para a quebra da dormência fisiológica, já que altera o balanço hormonal, sobretudo os níveis de giberelina. O trabalho teve por objetivo avaliar a aplicação de concentrações de GA3 na germinação de sementes de Punica granatum em ambiente controlado com temperatura de 25ºC e fotoperíodo de 12 horas de luz, sobre papel germitest. Adotou-se o delineamento inteiramente casualisado, com cinco tratamentos [concentrações de GA3 (0; 100; 200; 300 e 400 mgL-1], quatro repetições de 25 sementes cada. Determinou-se durante a embebição a curva de aquisição de água das mesmas. As variáveis avaliadas foram porcentagem de germinação, tempo médio de germinação, índice de velocidade de germinação, índice de sincronização e frequência de germinação, comprimento médio total (parte aérea + parte radicular, massa da matéria fresca e seca das plântulas. A única variável que mostrou efeito das concentrações de GA3 foi o índice de velocidade de emergência. O tempo de embebição necessário para atingir máximo teor de água nas sementes de romäzeira (P.granatum em água deionizada foi de quatro horas, sendo a embebição neste líquido o método eficaz para o processo germinativo, sem a necessidade de uso de giberelina.

  13. Punica granatum L.

    OpenAIRE

    2016-01-01

    На сегодняшний день накоплен огромный опыт применения плодов и коры граната в народной медицине. В настоящее время проведено значительное количество фармакологических исследований гранатового дерева, позволивших выявить антиоксидантное, антимикробное, противовоспалительное и противоопухолевое действия. Уже существует достаточно обширная доказательная база, подтверждающая терапевтические действия гранатового дерева на живые организмы. Область применения экстрактов и извлечений из плодов и кожу...

  14. Punica granatum L.

    African Journals Online (AJOL)

    STORAGESEVER

    2008-05-02

    May 2, 2008 ... Belaj A, Caballero JM, Barranco D, Rallo L, Trujillo I (2003). Genetic characterization and identification of new accessions from Syria in an. Olive germplasm bank by means of RAPD markers. Euphytica 134: 261-268. Bernalte MJ, Sabio E, Hernandez MT, Gervasini C (2003). Influence of storage delay on ...

  15. Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract

    Directory of Open Access Journals (Sweden)

    Bogdan C

    2017-02-01

    Full Text Available Cătălina Bogdan,1 Sonia Iurian,2 Ioan Tomuta,2 Mirela Moldovan1 1Department of Dermatopharmacy and Cosmetics, 2Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania Abstract: Striae distensae are a frequent skin condition associated with pregnancy, weight change or lack of skin elasticity. The aim of this research was to obtain a topical product containing herbal active ingredients with documented antioxidant and anti-inflammatory activity (Punica granatum seed oil and Croton lechleri resin extract and demonstrate its positive effect on prevention and treatment of striae distensae. First, the cream base formulation was optimized through experimental design. Secondly, the cream containing the two active ingredients was investigated in an interventional nonrandomized clinical trial. The clinical outcome was assessed through biophysical parameters and ultrasonographic evaluation. The state of the skin was evaluated by biophysical measurements and ultrasonography at the beginning of the study and after 3 and 6 weeks. The experimental design was successfully used to set the best ranges for the technological and formulation factors to obtain a cosmetic formulation with optimal characteristics. The study of clinical efficacy on the optimal formulation revealed an increase in the dermis thickness, hydration and elasticity values in both groups after 6 weeks of cream application. The new oil-in-water cream containing P. granatum seed oil and C. lechleri resin extract can be helpful in the prevention or improving of skin changes associated with striae. Keywords: stretch marks, ultrasonography, texture analysis, design of experiments, oil-in-water emulsion

  16. Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats.

    Science.gov (United States)

    Shaban, Nadia Z; El-Kersh, Mohamed A L; El-Rashidy, Fatma H; Habashy, Noha H

    2013-12-01

    The present study is an attempt to reveal the protective role of Punica granatum peel and seed oil extracts against diethylnitrosamine (DEN) and phenobarbital (PB) induced hepatic injury in rats. DEN administration increased the levels of malondialdehyde (MDA), DNA fragmentation, caspase-3 and glutathione reductase (GSR) activities, while the level of reduced glutathione (GSH) and the activities of superoxide dismutase (SOD), glutathione S-transferase (GST) and total glutathione peroxidase (t-GPx) were decreased compared with the control. Treatment with peel and seed oil extracts pre, during and post DEN administration improved liver functions, decreased the levels of MDA, DNA fragmentation, caspase-3 and GSR activities with an elevation in levels of GSH, SOD, GST and t-GPx activities. This indicates that these extracts reduced the oxidative stress and apoptosis induced by DEN. Also the effect of administration of PE and SOE separately for a long time (23 weeks) on healthy rats was studied. Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. Potential Anti-Inflammatory Effects of the Hydrophilic Fraction of Pomegranate (Punica granatum L. Seed Oil on Breast Cancer Cell Lines

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    Susan Costantini

    2014-06-01

    Full Text Available In this work, we characterized conjugated linolenic acids (e.g., punicic acid as the major components of the hydrophilic fraction (80% aqueous methanol extract from pomegranate (Punica granatum L. seed oil (PSO and evaluated their anti-inflammatory potential on some human colon (HT29 and HCT116, liver (HepG2 and Huh7, breast (MCF-7 and MDA-MB-231 and prostate (DU145 cancer lines. Our results demonstrated that punicic acid and its congeners induce a significant decrease of cell viability for two breast cell lines with a related increase of the cell cycle G0/G1 phase respect to untreated cells. Moreover, the evaluation of a great panel of cytokines expressed by MCF-7 and MDA-MB-231 cells showed that the levels of VEGF and nine pro-inflammatory cytokines (IL-2, IL-6, IL-12, IL-17, IP-10, MIP-1α, MIP-1β, MCP-1 and TNF-α decreased in a dose dependent way with increasing amounts of the hydrophilic extracts of PSO, supporting the evidence of an anti-inflammatory effect. Taken together, the data herein suggest a potential synergistic cytotoxic, anti-inflammatory and anti-oxidant role of the polar compounds from PSO.

  18. Potential anti-inflammatory effects of the hydrophilic fraction of pomegranate (Punica granatum L.) seed oil on breast cancer cell lines.

    Science.gov (United States)

    Costantini, Susan; Rusolo, Fabiola; De Vito, Valentina; Moccia, Stefania; Picariello, Gianluca; Capone, Francesca; Guerriero, Eliana; Castello, Giuseppe; Volpe, Maria Grazia

    2014-06-24

    In this work, we characterized conjugated linolenic acids (e.g., punicic acid) as the major components of the hydrophilic fraction (80% aqueous methanol extract) from pomegranate (Punica granatum L.) seed oil (PSO) and evaluated their anti-inflammatory potential on some human colon (HT29 and HCT116), liver (HepG2 and Huh7), breast (MCF-7 and MDA-MB-231) and prostate (DU145) cancer lines. Our results demonstrated that punicic acid and its congeners induce a significant decrease of cell viability for two breast cell lines with a related increase of the cell cycle G0/G1 phase respect to untreated cells. Moreover, the evaluation of a great panel of cytokines expressed by MCF-7 and MDA-MB-231 cells showed that the levels of VEGF and nine pro-inflammatory cytokines (IL-2, IL-6, IL-12, IL-17, IP-10, MIP-1α, MIP-1β, MCP-1 and TNF-α) decreased in a dose dependent way with increasing amounts of the hydrophilic extracts of PSO, supporting the evidence of an anti-inflammatory effect. Taken together, the data herein suggest a potential synergistic cytotoxic, anti-inflammatory and anti-oxidant role of the polar compounds from PSO.

  19. Antifungal activity of the ethanolic extracts of Punica granatum L. and evaluation of the morphological and structural modifications of its compounds upon the cells of Candida spp.

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    Paula Cristina Anibal

    2013-09-01

    Full Text Available Ethanolic crude extracts prepared from the arils and seeds, pericarp, peels and from the whole fruit of Punica granatum, known as pomegranate, had their antifungal activity tested against Candida spp. The ethanolic crude extracts were analyzed by Mass Spectrometry and yielded many compounds such as punicalagin and galladydilacton. The extracts from the pericarp and peel showed activity against Candida spp., with MICs of 125 µg/mL. The effect of pericarp and peel extracts upon the morphological and structure of C. albicans and C. krusei were examined by scanning and transmission electron microscopy, with the visualization of an irregular membrane and hyphae, formation of vacuoles and thickening of the cell wall. The data obtained revealed potential antimicrobial activity against yeasts cells of the Candida genus, and the bioactive compounds could be responsible for changes in cell morphology and structure. The data obtained open new perspectives for future research in continuation to this study, where information such as determination of the site of action of the compounds could contribute to an alternative therapy against these organisms.

  20. Protection against oxidative damage in human erythrocytes and preliminary photosafety assessment of Punica granatum seed oil nanoemulsions entrapping polyphenol-rich ethyl acetate fraction.

    Science.gov (United States)

    Baccarin, Thaisa; Mitjans, Montserrat; Lemos-Senna, Elenara; Vinardell, Maria Pilar

    2015-12-25

    The main purpose of the present study is to evaluate the ability of nanoemulsion entrapping pomegranate peel polyphenol-rich ethyl acetate fraction (EAF) prepared from pomegranate seed oil and medium chain triglyceride to protect human erythrocyte membrane from oxidative damage and to assess preliminary in vitro photosafety. In order to evaluate the phototoxic effect of nanoemulsions, human red blood cells (RBCs) are used as a biological model and the rate of haemolysis and photohaemolysis (5 J cm(-2) UVA) is assessed in vitro. The level of protection against oxidative damage caused by the peroxyl radical generator AAPH in human RBCs as well as its effects on bilayer membrane characteristics such as fluidity, protein profile and RBCs morphology are determined. EAF-loaded nanoemulsions do not promote haemolysis or photohaemolysis. Anisotropy measurements show that nanoemulsions significantly retrain the increase in membrane fluidity caused by AAPH. SDS-PAGE analysis reveals that AAPH induced degradation of membrane proteins, but that nanoemulsions reduce the extension of degradation. Scanning electron microscopy examinations corroborate the interaction between AAPH, nanoemulsions and the RBC membrane bilayer. Our work demonstrates that Punica granatum nanoemulsions are photosafe and protect RBCs against oxidative damage and possible disturbance of the lipid bilayer of biomembranes. Moreover it suggests that these nanoemulsions could be promising new topical products to reduce the effects of sunlight on skin. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. Effect of Genotype on the Sprouting of Pomegranate (Punica granatum L.) Seeds as a Source of Phenolic Compounds from Juice Industry by-Products.

    Science.gov (United States)

    Falcinelli, Beatrice; Marconi, Ombretta; Maranghi, Stefano; Lutts, Stanley; Rosati, Adolfo; Famiani, Franco; Benincasa, Paolo

    2017-12-01

    Pomegranate (Punica granatum L.) fruits are used mainly by the juice industry, for which seeds are a by-product to be disposed of, though they could potentially be a source of bioactive compounds. In this work, germination (total germination percentage, G; mean germination time, MGT; time to reach 80% of germination, TG80; seedling shoot length, fresh weight and dry matter), and nutritional value (total phenolics, TP; total flavonoids, TF; total non-tannins, TNT; antioxidant activities) of pomegranate seeds and sprouts were determined on four commercial pomegranate cultivars (Akko, Dente di Cavallo, Mollar de Elche and Wonderful). Seeds were removed from ripe fruits and incubated in plastic trays containing sterile cotton wetted with distilled water. Sprout shoots were harvested when they reached the complete cotyledon expansion, i.e., the ready-to-eat stage. Akko showed the best germination performance (G = 98%; MGT = 14 days after sowing, DAS; TG80 = 16 DAS), followed by Mollar de Elche. Sprouting dramatically increased TP, TF, TNT and antioxidant activity in all genotypes, with the highest values recorded in Mollar de Elche and Dente di Cavallo. Overall, based on germination performance, Akko and Mollar de Elche would be the best cultivars for sprouting. Sprouting pomegranate seeds appears to be a suitable way of utilizing by-products of the juice industry to obtain bioactive compounds.

  2. Application of response surface methodology for the optimization of supercritical fluid extraction of essential oil from pomegranate (Punica granatum L.) peel.

    Science.gov (United States)

    Ara, Katayoun Mahdavi; Raofie, Farhad

    2016-07-01

    Essential oils and volatile components of pomegranate (Punica granatum L.) peel of the Malas variety from Meybod, Iran, were extracted using supercritical fluid extraction (SFE) and hydro-distillation methods. The experimental parameters of SFE that is pressure, temperature, extraction time, and modifier (methanol) volume were optimized using a central composite design after a (24-1) fractional factorial design. Detailed chemical composition of the essential oils and volatile components obtained by hydro-distillation and optimum condition of the supercritical CO2 extraction were analyzed by GC-MS, and seventy-three and forty-six compounds were identified according to their retention indices and mass spectra, respectively. The optimum SFE conditions were 350 atm pressure, 55 °C temperature, 30 min extraction time, and 150 µL methanol. Results showed that oleic acid, palmitic acid and (-)-Borneol were major compounds in both extracts. The optimum extraction yield was 1.18 % (w/w) for SFE and 0.21 % (v/w) for hydro-distillation.

  3. Efek ekstrak buah delima (Punica Granatum L terhadap ekspresi wild p53 pada sel ganas rongga mulut mencit strain swiss webster

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    Sri Hernawati

    2013-09-01

    Full Text Available Background: Squamous cell carcinoma is the most common cancer in the oral cavity. DNA tests showed that almost 90% of cases revealed wild p53 gene mutations. Wild p53 gene mutations cause p53 inactivation so the cell cycle does not stop in G1 phase but continues to S phase and G2 and M, it makes the mutated DNA remains multiplied and apoptosis does not occur. One candidate of the cancer treatment alternatives is pomegranate extract (Punica granatum L – PGL. Purpose: The purpose of study was to examine the effect of PGL on wild p53 expression in oral cavity malignant cell of swiss webster strain mice. Methods: Thirty- two swiss webster strain mice (Balb/c 5 months old were randomly divided into four groups. Two control groups (K0: no benzopirene exposed and untreated; K1: benzopirene exposed and untreated; and 2 treatment groups (P1: benzopirene exposed and given EA; P2: benzopirene exposed and given PGL extract. The expression of wild p53 was determined by immunohistochemical techniques. Results: The results showed that administration of PGL could increase the expression of wild p53 in malignant epithelial cells in the oral mucosa of mice, and the expression was higher than EA. Conclusion: This study suggested that the PGL extract could express wild p53 in the oral cavity malignant cells of swiss Webster strains mice.Latar belakang: Karsinoma sel skuamosa merupakan kanker yang sering terjadi pada rongga mulut. Pemeriksaan DNA menunjukkan hampir 90% kasus dijumpai adanya mutasi gen wild p53. Mutasi gen wild p53 menyebabkan inaktivasi wild p53 sehingga siklus sel tidak berhenti pada fase G1 tetapi berlanjut ke fase S dan G2 dan M, sehingga DNA yang mengalami mutasi tetap dilipatgandakan dan apoptosis tidak terjadi. Salah satu kandidat obat kanker adalah ekstrak buah delima (Punica Granatum L - PGL. Tujuan: Penelitian ini bertujuan untuk meneliti efek ekstrak PGL terhadap ekspresi wild p53 pada sel ganas rongga mulut mencit strain swiss webster

  4. Desarrollo de un proceso tecnológico a escala de laboratorio para la extracción de polifenoles totales del fruto de la Punica granatum L

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    Jorge Enrique Rodríguez Chanfrau

    Full Text Available Introducción: Punica granatum L., (Punicaceae es una especie conocida en Cuba como granada. Algunos fitocomponentes presentes en la fruta muestran una fuerte actividad antioxidante. En la medicina tradicional esta planta es empleada en el tratamiento de infecciones parasitarias, diarreas y disentería, así como en el tratamiento de asma, catarro, fiebre, inflamaciones y otras. En años recientes, la actividad biológica de los polifenoles presentes en la fruta de esta especie, ha despertado el interés de los investigadores y la industria farmacéutica. Objetivo: establecer un proceso a escala de laboratorio que permita extraer los polifenoles totales de la fruta. Métodos: se aplicó un proceso de maceración para la extracción de los polifenoles de la fruta y se realizó la optimización de los parámetros mediante diseños experimentales. Se evaluaron las variables independientes: tiempo de extracción, relación droga-menstruo y concentración alcohólica. Resultados: las tres variables presentaron una influencia significativa sobre el proceso de extracción de polifenoles. Conclusiones: en las condiciones de trabajo establecidas, la extracción óptima es la siguiente: tiempo de extracción de 72 h, relación droga-menstruo de 1:20 y concentración alcohólica del 50 % (v/v.

  5. Metabolite fingerprinting of Punica granatum L. (pomegranate) polyphenols by means of high-performance liquid chromatography with diode array and electrospray ionization-mass spectrometry detection.

    Science.gov (United States)

    Brighenti, Virginia; Groothuis, Sebastiaan Frearick; Prencipe, Francesco Pio; Amir, Rachel; Benvenuti, Stefania; Pellati, Federica

    2017-01-13

    The present study was aimed at the development of a new analytical method for the comprehensive multi-component analysis of polyphenols in Punica granatum L. (pomegranate) juice and peel. While pomegranate juice was directly analysed after simple centrifugation, different extraction techniques, including maceration, heat reflux extraction, ultrasound-assisted extraction and microwave-assisted extraction, were compared in order to obtain a high yield of the target analytes from pomegranate peel. Dynamic maceration with a mixture of water and ethanol 80:20 (v/v) with 0.1% of hydrochloric acid as the extraction solvent provided the best result in terms of recovery of pomegranate secondary metabolites. The quali- and quantitative analysis of pomegranate polyphenols was performed by high-performance liquid chromatography with diode array and electrospray ionization-mass spectrometry detection. The application of fused-core column technology allowed us to obtain an improvement of the chromatographic performance in comparison with that of conventional particulate stationary phases, thus enabling a good separation of all constituents in a shorter time and with low solvent usage. The analytical method was completely validated to show compliance with the International Conference on Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use guidelines and successfully applied to the characterisation of commercial and experimental pomegranate samples, thus demonstrating its efficiency as a tool for the fingerprinting of this plant material. The quantitative data collected were submitted to principal component analysis, in order to highlight the possible presence of pomegranate samples with high content of secondary metabolites. From the statistical analysis, four experimental samples showed a notable content of bioactive compounds in the peels, while commercial ones still represent the best source of healthy juice. Copyright © 2016 Elsevier

  6. Total phenolic and flavonoid content and antibacterial activity of Punica granatum L. var. pleniflora flowers (Golnar) against bacterial strains causing foodborne diseases.

    Science.gov (United States)

    Mahboubi, Arash; Asgarpanah, Jinous; Sadaghiyani, Parisa Nosrati; Faizi, Mehrdad

    2015-10-15

    Flowers of Punica granatum L. (Punicaceae) var. pleniflora, known as "Golnar" in Iranian traditional medicine have been used for the prevention and treatment of foodborne diseases. In this study, antibacterial activities of ethanol extract of Golnar and its fractions were scientifically evaluated against bacteria causing foodborne diseases including Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Escherichia coli, Shigella dysantriae, and Salmonella typhi. The total phenolic and flavonoid contents of the extract and its fractions were also determined. The antibacterial effect of the ethanol extract and its fractions were primarily evaluated by agar well diffusion and their MIC and MBC were determined by broth macro dilution method. The total phenolic and flavonoid contents of the extract and its fractions were measured based on gallic acid and rutin equivalents (GAE and RE), respectively. After evaluation of total phenolic and flavonoid content the chloroform fraction showed the lowest phenolic and flavonoid contents (3.8 mg GAE/g and 1.1 mg RE/g respectively) and the methanol fraction showed the highest phenolic and flavonoid contents (18.1 mg GEA/g and 3.3 mg RE/g respectively). The total phenolic and flavonoid content was positively associated with the antibacterial activities of the fractions with chloroform extract exhibiting lowest antibacterial activity against E. coli (MIC 25 mg/ml) and the methanol fraction exhibiting the highest antibacterial effect against S. aureus (MIC 0.19 mg/ml). Golnar extract showed antibacterial activity against both Gram positive and Gram negative bacteria causing food poisoning. Therefore, the extract can be used for prevention or treatment of foodborne diseases or as preservative in the food industry. The methanol fraction with the highest phenolic and flavonoid content showed the highest antibacterial effect. This indicates that the phenolic and flavonoid compounds in the extract can be responsible for the

  7. In vitro antioxidant, collagenase inhibition, and in vivo anti-wrinkle effects of combined formulation containing Punica granatum, Ginkgo biloba, Ficus carica, and Morus alba fruits extract

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    Ghimeray AK

    2015-07-01

    Full Text Available Amal Kumar Ghimeray,1 Un Sun Jung,1,2 Ha Youn Lee,1 Young Hoon Kim,1 Eun Kyung Ryu,1 Moon Sik Chang11R&D Center, Natural Solution Co., Ltd, Gojan-dong, Namdong-gu, Incheon, Republic of Korea; 2Department of Horticultural Biotechnology, Kyung Hee University, Yongin, Republic of KoreaBackground: In phytotherapy, the therapeutic potential is based on the combined action of different herbal drugs. Our objective was to evaluate the antioxidant, anti-collagenase (in vitro, and anti-wrinkle (in vivo effect of combined formulation containing Ginkgo biloba, Punica granatum, Ficus carica, and Morus alba fruits extract.Methods: Antioxidant evaluation was based on the scavenging activity of free radicals (1,1-diphenyl-2-picrylhydrazyl, H2O2, and O2- and the anti-collagenase activity was based on the reduction of collagenase enzyme in vitro. In an in vivo study, 21 female subjects were examined in a placebo-controlled trail. Facial wrinkle, especially the crow's feet region of eyes, was treated with topical formulated 2% cream for 56 days and compared with the placebo.Results: In the in vitro study, the combination of fruits extract showed a higher antioxidant activity which was comparable with the positive standard (ascorbic acid, butylated hydroxyanisole, and Trolox. The data also showed a dose-dependent inhibition of collagenase. In the in vivo study, treatment with 2% formulated cream for 56 days significantly reduced the percentage of wrinkle depth, length, and area with 11.5, 10.07, and 29.55, respectively.Conclusion: The combined formulation of fruit extracts showed excellent antioxidative and anti-collagenase activity as well as a significant effect on anti-wrinkle activity on human skin.Keywords: antioxidant, anti-collagenase, anti-wrinkle, fruits, topical formulation

  8. Medicinal values of fruit peels from Citrus sinensis, Punica granatum, and Musa paradisiaca with respect to alterations in tissue lipid peroxidation and serum concentration of glucose, insulin, and thyroid hormones.

    Science.gov (United States)

    Parmar, Hamendra Singh; Kar, Anand

    2008-06-01

    Peel extracts from Citrus sinensis, Punica granatum, and Musa paradisiaca were investigated for their effects on tissue lipid peroxidation (LPO) and on the concentration of thyroid hormones, insulin, and glucose in male rats. In vitro inhibition of H(2)O(2)-induced LPO in red blood cells of rats by 0.25, 0.50, 1.0, and 2.0 microg/mL C. sinensis, P. granatum, and M. paradisiaca peel extracts was observed in a dose-specific manner. Maximum inhibition was observed at 0.50 microg/mL C. sinensis, 2.0 microg/mL P. granatum, and 1.0 microg/mL M. paradisiaca. In the in vivo investigation, out of four different concentrations of each peel extract, 25, 200, and 100 mg/kg C. sinensis, P. granatum, and M. paradisiaca, respectively, were found to maximally inhibit hepatic LPO. The most effective doses were further evaluated for effects on serum triiodothyronine (T(3)), thyroxine (T(4)), insulin, and glucose concentrations. C. sinensis exhibited antithyroidal, hypoglycemic, and insulin stimulatory activities, in addition to inhibition of LPO, as it significantly decreased the serum T(4) (P paradisiaca strongly inhibited the serum level of thyroid hormones (P < .01 for both T(3) and T(4)) but increased the level of glucose (P < .05). These findings reveal the hitherto unknown potential of the tested peel extracts in the regulation of thyroid function and glucose metabolism. Besides antiperoxidative activity, C. sinensis extract has antithyroidal, hypoglycemic, and insulin stimulatory properties, which suggest its potential to ameliorate both hyperthyroidism and diabetes mellitus.

  9. Effect of Sodium Chloride Concentrations and Its Foliar Application Time on Quantitative and Qualitative Characteristics of Pomegranate Fruit (Punica granatum L. CV. “Malas Saveh”

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    V. Rouhi

    2016-02-01

    Full Text Available Introduction: Pomegranate (Punica granatum L. belong to Punicaceae family is native to Iran and grown extensively in arid and semi-arid regions worldwide. Pomegranate is also important in human medicine and its components have a wide range of clinical applications. Cracking causes a major fruit loss, which is a serious commercial loss to farmers. Fruit cracking, seems to be a problem that lessens the marketability to a great extent. Fruit cracking is one of the physiological disorders wherever pomegranate trees are grown. It may be due to moisture imbalances as this fruit is very sensitive to variation in soil moisture prolonged drought causes hardening of skin and if this is followed by heavy irrigation the pulp grows then skin grows and cracks. Many factors i.e., climate, soil and irrigation, varieties, pruning, insects and nutrition statues influence the growth and production of fruit trees. Deficiencies of various nutrients are related to soil types, plants and even to various cultivars. Most nutrients are readily fixed in soil having different PH. Plant roots are unable to absorb these nutrients adequately from the dry topsoil. Foliar fertilization is particularly useful under conditions where the absorption of nutrients through the soil and this difficult situation to be present in the nutrients such as calcium. Since the calcium element is needed, so spraying them at the right time is correct way to save the plant requirements. Therefore, a research conducted on effect of sodium chloride concentrations and its foliar application time on quantitative and qualitative characteristics of pomegranate fruit (Punica granatum L. CV. “Malas Saveh”. Materials and Methods: An experiment conducted at Jarghoyeh, Esfahan, Iran in 2012. The factors were Sodium chloride (0, 5 and 10 g/L and times of spray (15, 45 and 75 days before harvest. The study was factorial experiment in the base of randomized complete blocks design with three replications

  10. Efecto del extracto hidroalcohólico del fruto de granada (Punica granatum L.) presentada en forma de gel farmacéutico en el tratamiento de las hemorroides

    OpenAIRE

    Bell Cortez, Carlos Alejandro

    2016-01-01

    Se evaluó el efecto de gel formulado a base de extracto hidroalcoholico del fruto de la granada (Punica granatum L.), sobre las hemorroides, en 50 voluntarios de ambos sexos con edades comprendidas entre 20 y 50 años, todos residentes en la ciudad de Lima (Perú). La aplicación y seguimiento farmacológico se realizó dos veces al día durante un mes; la dosis vario según el tamaño de la hemorroides; se excluyó la utilización de cualquier otro preparado convencional. El ensayo, previo consentimie...

  11. Photoprotection by Punica granatum seed oil nanoemulsion entrapping polyphenol-rich ethyl acetate fraction against UVB-induced DNA damage in human keratinocyte (HaCaT) cell line.

    Science.gov (United States)

    Baccarin, Thaisa; Mitjans, Montserrat; Ramos, David; Lemos-Senna, Elenara; Vinardell, Maria Pilar

    2015-12-01

    There has been an increase in the use of botanicals as skin photoprotective agents. Pomegranate (Punica granatum L.) is well known for its high concentration of polyphenolic compounds and for its antioxidant and anti-inflammatory properties. The aim of this study was to analyze the photoprotection provided by P. granatum seed oil nanoemulsion entrapping the polyphenol-rich ethyl acetate fraction against UVB-induced DNA damage in the keratinocyte HaCaT cell line. For this purpose, HaCaT cells were pretreated for 1h with nanoemulsions in a serum-free medium and then irradiated with UVB (90-200 mJ/cm(2)) rays. Fluorescence microscopy analysis provided information about the cellular internalization of the nanodroplets. We also determined the in vitro SPF of the nanoemulsions and evaluated their phototoxicity using the 3T3 Neutral Red Uptake Phototoxicity Test. The nanoemulsions were able to protect the cells' DNA against UVB-induced damage in a concentration dependent manner. Nanodroplets were internalized by the cells but a higher proportion was detected along the cell membrane. The SPF obtained (~25) depended on the concentration of the ethyl acetate fraction and pomegranate seed oil in the nanoemulsion. The photoprotective formulations were classified as non-phototoxic. In conclusion, nanoemulsions entrapping the polyphenol-rich ethyl acetate fraction show potential for use as a sunscreen product. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs

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    Nabil Abdel Salam Ahmed Hasona

    2017-03-01

    Conclusions: The Iranian T. foenum-graecum seeds and P. granatum peel extracts are significantly potent in ameliorating diabetic condition induced by streptozotocin and improving various biochemical parameters in serum and liver of guinea pigs.

  13. Correlation between geography and cytogenetic diversity in Pomegranate (Punica granatum L. cultivars in Iran Correlação entre a distribuição geográfica e diversidade citogenética de cultivares de romã (Punica granatum L. no Irã

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    Masoud Sheidai

    2012-12-01

    Full Text Available Pomegranate (Punica granatum L. is an important horticultural plant with several cultivated forms planted in different regions of Iran. Due to its economic importance, studies have been carried out to illustrate the genetic diversity at the chromosomal and molecular levels in different pomegranate cultivars growing in this region. This study analyzed chromosome pairing and B-chromosomes of 21 pomegranate cultivars and tried to investigate the effects of geographical parameters like altitude and longitude as well as elevation and the mean annual rainfall on cytogenetic diversity of these taxa. An ANOVA test revealed the presence of a significant difference for chiasmata and chromosome pairing among the cultivars, indicating their genetic differences. A positive significant correlation was observed between total chiasma frequency and terminal chiasmata, intercalary chiasmata and the mean number of quadrivalents. A significant positive correlation was observed between annual rainfall and the mean number of rod bivalents, while a significant negative correlation was found for the number of ring bivalents. Altitude did not show any correlation with the cytogenetic characters studied, but showed a significant negative correlation with the number of univalents. Longitude showed significant positive correlation with the number of ring bivalents and a negative correlation with the number of univalents and intercalary chiasmata. PCA analysis showed that both geographical and cytological features contribute greatly in the diversity observed in the pomegranate cultivars. The occurrence of multipolar cells and unreduced pollen grains were observed in some of the cultivars.A romã (Punica granatum L. é uma planta hortícola importante com diversas formas de cultura plantadas em diferentes regiões do Irã. Devido à sua importância econômica, alguns estudos genéticos têm sido realizados para ilustrar a diversidade genética em ambos os níveis cromoss

  14. Study of pomegranate (Punica granatum L.) peel extract containing anthocyanins on fatty streak formation in the renal arteries in hypercholesterolemic rabbits.

    Science.gov (United States)

    Sharifiyan, Fatemeh; Movahedian-Attar, Ahmad; Nili, Nafiseh; Asgary, Sedigheh

    2016-01-01

    The influence of the supplementation of pomegranate peel extract containing anthocyanins on atherosclerotic plaque formation induced by hypercholesterolemia was investigated in renal arteries in rabbits. After the determination of polyphenol and anthocyanin's content of P. granatum peel hydroalcoholic extract, 30 male rabbits were randomly divided into three groups. They were fed basic diet, hypercholesterolemic diet and hypercholesterolemic diet along with P. granatum peel extract (polyphenolic content for each rabbit 1 g/kg diet) for 2 month. Blood samples were collected at the begging, middle and end of the study in order to measure lipid concentration and oxidative and antioxidative status variables, and renal arteries were taken for the assessment of atherosclerotic plaques at the end of the study. The results reveal that P. granatum peel extract significantly increases serum antioxidant capacity in the extract recipient group in comparison with hypercholesterolemic control (P 0.05). The results of this study indicate that consumption of pomegranate peel extract containing anthocyanins (polyphenol content 1 g/kg diet) despite of a significant increase in serum antioxidant capacity cannot protect the kidneys from hypercholesterolemia-induced damages during the treatment period.

  15. Effect of pectin methyl esterase and Ca²⁺ ions treatment on antioxidant capacity, shelf-life and quality of minimally processed pomegranate (Punica granatum L.) arils.

    Science.gov (United States)

    Kumar, Sunil; Kumar, Ramesh; Nambi, V E

    2016-03-01

    Pomegranate fruits are difficult to peel and once peeled, extracted arils have very short shelf-life. Therefore, present investigation was carried out to extend the shelf life of minimally processed pomegranate arils using pectin methyl esterase (PME) and CaCl2 treatment during refrigerated storage. The arils of freshly harvested pomegranate fruits (Punica granatum L.) were treated with different concentrations of food-grade PME (50-300 units) and calcium ions (0.5-2.0% CaCl₂) for a period of 5-30 min using response surface methodology. Treated and untreated arils were then packed in low density polyethylene bags (25 μ) and maintained under low temperature (5°C; 90% RH) for evaluating the physical, biochemical and microbial quality of pomegranate arils at four day interval. Physiological loss in weight increased during storage but no food-borne pathogens were found during 28 day of cold storage in treated arils. Color and firmness of both treated and untreated arils decreased during storage but it was better maintained in treated arils. The firmness was found to be 0.630 N in treated samples compared to untreated one (0.511 N) after 20 d of storage. Total antioxidant capacity, ferric reducing antioxidant power, polyphenol oxidase and lipoxygenase activities increased during storage. Treatment with 249.33 units of PME and 1.70% CaCl₂for an immersion time of 24.93 min was found to be most effective treatment for maintaining the quality of minimally processed arils for longer period. Sensory score was also higher in treated pomegranate arils that were quite acceptable even after 20 day of referigerated storage as against 12 day for untreated ones.

  16. A pomegranate (Punica granatum L.) WD40-repeat gene is a functional homologue of Arabidopsis TTG1 and is involved in the regulation of anthocyanin biosynthesis during pomegranate fruit development.

    Science.gov (United States)

    Ben-Simhon, Zohar; Judeinstein, Sylvie; Nadler-Hassar, Talia; Trainin, Taly; Bar-Ya'akov, Irit; Borochov-Neori, Hamutal; Holland, Doron

    2011-11-01

    Anthocyanins are the major pigments responsible for the pomegranate (Punica granatum L.) fruit skin color. The high variability in fruit external color in pomegranate cultivars reflects variations in anthocyanin composition. To identify genes involved in the regulation of anthocyanin biosynthesis pathway in the pomegranate fruit skin we have isolated, expressed and characterized the pomegranate homologue of the Arabidopsis thaliana TRANSPARENT TESTA GLABRA1 (TTG1), encoding a WD40-repeat protein. The TTG1 protein is a regulator of anthocyanins and proanthocyanidins (PAs) biosynthesis in Arabidopsis, and acts by the formation of a transcriptional regulatory complex with two other regulatory proteins: bHLH and MYB. Our results reveal that the pomegranate gene, designated PgWD40, recovered the anthocyanin, PAs, trichome and seed coat mucilage phenotype in Arabidopsis ttg1 mutant. PgWD40 expression and anthocyanin composition in the skin were analyzed during pomegranate fruit development, in two accessions that differ in skin color intensity and timing of appearance. The results indicate high positive correlation between the total cyanidin derivatives quantity (red pigments) and the expression level of PgWD40. Furthermore, strong correlation was found between the steady state levels of PgWD40 transcripts and the transcripts of pomegranate homologues of the structural genes PgDFR and PgLDOX. PgWD40, PgDFR and PgLDOX expression also correlated with the expression of pomegranate homologues of the regulatory genes PgAn1 (bHLH) and PgAn2 (MYB). On the basis of our results we propose that PgWD40 is involved in the regulation of anthocyanin biosynthesis during pomegranate fruit development and that expression of PgWD40, PgAn1 and PgAn2 in the pomegranate fruit skin is required to regulate the expression of downstream structural genes involved in the anthocyanin biosynthesis.

  17. Effect of S. macrosiphon and L. perfoliatum seed gums on rheological characterization of bitter orange (Citrus aurantium L.) and pomegranate (Punica granatum L.) paste blends

    OpenAIRE

    Asnaashari, Maryam; Motamedzadegan, Ali; Farahmandfar, Reza; Rad, Tandis Khosravi

    2015-01-01

    The steady shear flow properties of bitter orange and pomegranate pastes and blend of two pastes including 0.5% Salvia macrosiphon (SMG) and L. perfoliatum (LPG) seed gums, two traditional Iranian hydrocolloids, were determined. All treatments exhibited shear-thinning behaviour. LPG added sample showed stronger shear thinning behaviour than the other due to its high molecular weight and intermolecular through hydrogen bonds and polymer entanglement. Ostwald model was found the best model to d...

  18. Antitrypanosomal Potentials of Ethanolic Leaf Extracts of Punica ...

    African Journals Online (AJOL)

    Three doses (20mg/kg, 40mg/kg,80mg/kg) of ethanolic extracts of the leaves of Punica granatum were screened for trypanocidal activity against Trypanosoma brucei bruce in Balb Strain Albino mice. Parasitaemia and disappearance of clinical signs were used as parameters to monitor the efficacy of the extracts using the ...

  19. Effect of S. macrosiphon and L. perfoliatum seed gums on rheological characterization of bitter orange (Citrus aurantium L.) and pomegranate (Punica granatum L.) paste blends.

    Science.gov (United States)

    Asnaashari, Maryam; Motamedzadegan, Ali; Farahmandfar, Reza; Rad, Tandis Khosravi

    2016-02-01

    The steady shear flow properties of bitter orange and pomegranate pastes and blend of two pastes including 0.5% Salvia macrosiphon (SMG) and L. perfoliatum (LPG) seed gums, two traditional Iranian hydrocolloids, were determined. All treatments exhibited shear-thinning behaviour. LPG added sample showed stronger shear thinning behaviour than the other due to its high molecular weight and intermolecular through hydrogen bonds and polymer entanglement. Ostwald model was found the best model to describe steady shear flow behaviour among different time-independent rheological model applied. Treatments including 0.5% these two seed gums indicated a flow behaviour index less than 0.6 and consistency coefficient raised by increasing concentration from 60 °Bx to 76 °Bx in bitter orange paste (from 0.55 Pa s(n) to 32.58 Pa s(n)), pomegranate paste (from 0.55 Pa s(n) to 84.87 Pa s(n)) and mix of these two pastes (from 0.64 Pa s(n) to 56.9 Pa s(n)). Oscillatory shear data showed weak gel-like behaviour of bitter orange and pomegranate pastes treatments including seed gums with the elastic modulus predominating over the viscous one at lower frequency. However, after weak gel formation, G″ was higher than G' in the frequency range of 0.01 to 10 Hz. An Ostwald model was used to describe the changes of viscose modulus with frequency. The results indicate that the elastic properties of bitter orange/ pomegranate paste and bitter orange paste may be increased by the presence of LPG and SMG due to associations of ordered chain segments of these gums, resulting in a weak three-dimensional network.

  20. Antibacterial Activity of Punica granatum Linn.

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    Kenan Tunç

    2013-08-01

    Full Text Available In this study, it was investigated that the extracts (ethanol, aceton, methanol, ethyl acetat obtained from fruit peels of the plant to whether has antibacterial effect against Streptococcus mitis CNCTC 4/77, Streptococcus salivarius CNCTC 64/59, Streptococcus mutans CNCTC 8/77, Staphylococcus epidermidis ATCC 12228, Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Salmonella abony NCTC 6017, Salmonella typhimurium ATCC 14028, Enterococcus faecalis ATCC 29212, Bacillus subtilis ATCC 6633 bacteria strains in vitro. The antibacterial activity of extracts was evaluated according to disc diffusion method. It has been determined that pomegranate peel's extract had the highest inhibition zone diameters ( 18-30 mm against S. epidermidis and S. aureus bacteria strains. The antibacterial activity of plant against Streptococcus mitis is determined in this study for the first time.

  1. Antiplaque and antigingivitis effects of a gel containing Punica granatum Linn extract: a double-blind clinical study in humans Efeito antiplaca e antiinflamatório de um gel contendo extrato de romã: estudo clínico duplo-cego em humanos

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    Alexandre Daher Yunes Salgado

    2006-06-01

    Full Text Available OBJECTIVES: The antiplaque and antigingivitis effects of a gel containing 10% Punica granatum Linn extract were evaluated using a 21-day partial-mouth experimental model of gingivitis. METHODS: 23 volunteers participated in this cross-over, double-blind study, carried out in 2 phases of 21 days each. For each period of the experiment, an acrylic toothshield was made for each volunteer to carry the test or placebo gel as well as to avoid brushing of the 4 experimental teeth (posterior teeth in the lower left quadrant. The subjects were randomly assigned to use either the placebo gel (control group or the test gel (experimental group and were instructed to brush the remaining teeth normally 3 times a day. On days 0 and 21, the visible plaque index (VPI and gingival bleeding index (GBI were recorded. RESULTS: The results did not show statistically significant difference between control and experimental groups for either of the indices (VPI and GBI. CONCLUSION: The gel containing 10% Punica granatum Linn extract was not efficient in preventing supragingival dental plaque formation and gingivitis.OBJETIVOS: O efeito antiplaca e antigengivite de um gel contendo extrato de romã a 10% foi avaliado utilizando um modelo de gengivite experimental parcial em humanos. MÉTODOS: 23 indivíduos participaram voluntariamente deste estudo cruzado, duplo-cego, compreendendo dois períodos de 21 dias cada um. Uma moldeira de acrílico foi confeccionada para cada participante, a qual foi utilizada como carreadora dos géis sobre a área a ser avaliada (hemiarco inferior esquerdo. Os sujeitos foram aleatoriamente designados para usar o gel placebo (grupo controle ou o gel teste (grupo experimental, sendo instruídos a colocar o gel na moldeira e esta sobre os dentes teste, escovando os outros normalmente três vezes ao dia. No dia 0 e dia 21 os índices de placa visível (IPV e índice de sangramento gengival (ISG foram registrados. RESULTADOS: Os resultados n

  2. Study of biosorptive potential in the peel of Citrus reticulata, Punica ...

    African Journals Online (AJOL)

    Different physiochemical parameters such as color, odour, taste, pH, Electrical conductivity, total dissolved solids, concentration of cations & anions were determined in the waste water samples that were collected in the vicinity of Kuala Lumpur city. Peel of Citrus reticulata (orange), Punica granatum (pomegranate), Daucus ...

  3. Evaluation des Activities Analgesique et Antipyretique de Punica ...

    African Journals Online (AJOL)

    Le grenadier (Punica granatum L.) est une plante largement utilisée dans de nombreuses médecines traditionnelles. Le but de ce travail était d'évaluer et de comparer les propriétés analgésiques et antipyrétiques de l'extrait méthanolique de deux variétés de grenades: Amrouz (MoEA) et Sefri (MoES). Le test de ...

  4. Evaluation of Wound Healing Effect of Punica granatum L Peel ...

    African Journals Online (AJOL)

    1Department of Plastic & Cosmetic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021,. 2Department of ... Methods: Male Wistar rats, weighing 220 – 240 g, were subjected to deep second-degree skin burns by ... well as histopathological features of skin were evaluated for all the groups.

  5. Anti-Ulcerative Potential of Punica granatum L (Lythraceae ...

    African Journals Online (AJOL)

    ulcerated animals treated with white peel (50 mg/kg) showed severe erosion of gastric mucosa, sub- mucosal edema and neutrophil infiltration. ... between offensive, including acid, pepsin and H. pylori, and defensive factors such as mucin, ... temperature, the amount of rainfall, relative humidity, and the soil pH in growing ...

  6. Medicinal Uses of Punica Granatum And Its Health Benefits

    OpenAIRE

    Debjit Bhowmik; Harish Gopinath; B. Pragati Kumar; S.Duraivel; Aravind. G; K. P. Sampath Kumar

    2013-01-01

    Pomegranate has been used for thousands of years to cure a wide range of diseases across different cultures and civilizations. It has great nutritional values and numerous health benefits. Pomegranates as a Treatment for Cancer, Osteoarthritis and Other Diseases. The pomegranate has been used in natural and holistic medicine to treat sore throats, coughs, urinary infections, digestive disorders, skin disorders, arthritis, and to expel tapeworms. However, modern research suggests that pomegran...

  7. Evaluation of Punica granatum Peel Against Diabetic Wound Infection

    African Journals Online (AJOL)

    Background: Foot infections are a common and serious problem in diabetic patients. Objectives: To investigate the antibacterial activity of some medicinal plants used by traditional healers for diabetic wounds and to examine in-vivo wound healing activity of active extracts. Materials and Methods: An experimental study in ...

  8. Protective effects of Punica granatum seeds extract against aging ...

    African Journals Online (AJOL)

    Dementia is one of the age related mental problems and characteristic symptom of various neurodegenerative diseases including Alzheimer's disease. This impairment probably is due to the vulnerability of the brain cells to increased oxidative stress during aging process. Many studies have shown that certain phenolic ...

  9. The effect of extract of Punica granatum var. pleniflora for treatment of minor recurrent aphthous stomatitis

    OpenAIRE

    Gavanji, Shahin; Larki, Behrouz; Bakhtari, Azizollah

    2014-01-01

    Background: Herbal drugs are considered alternative agents and have been used for several years around the world. Recurrent aphthous stomatitis (RAS) is one of the most common problems recognized by dentists and skin specialists. This problem is characterized by recurring, painful, small oral mucosal ulcers with a round or oval aspect that mostly appear in keratinized mucosa, cheeks, and on the surface of the mouth under the tongue. Methods: In our experiment, the alcoholic and water extra...

  10. Pomegranate juice (punica granatum: a new storage medium for avulsed teeth.

    Directory of Open Access Journals (Sweden)

    Sara Tavassoli-Hojjati

    2014-04-01

    Full Text Available There is evidence indicating that pomegranate juice contains many of the essential properties necessary to retain cell viability and cell proliferation. These properties indicate that pomegranate juice is a suitable storage medium for avulsed teeth. However, this idea has not yet been tested. In this study, the capacity of pomegranate juice (PJ as a storage medium for retaining avulsed teeth was evaluated.PDL fibroblasts were obtained from healthy human premolars and cultured in Dulbecco's Modified Eagle's Medium (DMEM. Cultured cells were subjected to different concentrations of pomegranate juice (PJ, 1% Hank's balanced salt solution (HBSS and tap water for 1, 3, 6 and 24 hours. PDL cell viability was assessed by the neutral red uptake assay.The results indicated that 7.5% PJ was the most effective solution for maintaining PDL cell viability amongst all the experimental solution's and time intervals (P<0.05. The results also showed that 1% PJ was as effective as HBSS for maintaining PDL cell viability. The amount of cell viability increased with increasing concentration of PJ at all time intervals (P<0.001. This effect is suggestive of the proliferative potential of PJ solution.In conclusion, PJ can be recommended as a suitable transport medium for avulsed teeth.

  11. Pomegranate Juice (Punica Granatum): A New Storage Medium for Avulsed Teeth

    Science.gov (United States)

    Tavassoli-Hojjati, Sara; Aliasghar, Elham; Babaki, Fatemeh Ahmadian; Emadi, Fatemeh; Parsa, Maliheh; Tavajohi, Shohreh; Ahmadyar, Maryam; Ostad, Seyed Nasser

    2014-01-01

    Objective There is evidence indicating that pomegranate juice contains many of the essential properties necessary to retain cell viability and cell proliferation. These properties indicate that pomegranate juice is a suitable storage medium for avulsed teeth. However, this idea has not yet been tested. In this study, the capacity of pomegranate juice (PJ) as a storage medium for retaining avulsed teeth was evaluated. Materials and Methods: PDL fibroblasts were obtained from healthy human premolars and cultured in Dulbecco’s Modified Eagle’s Medium (DMEM). Cultured cells were subjected to different concentrations of pomegranate juice (PJ), 1% Hank’s balanced salt solution (HBSS) and tap water for 1, 3, 6 and 24 hours. PDL cell viability was assessed by the neutral red uptake assay. Results: The results indicated that 7.5% PJ was the most effective solution for maintaining PDL cell viability amongst all the experimental solution’s and time intervals (P<0.05). The results also showed that 1% PJ was as effective as HBSS for maintaining PDL cell viability. The amount of cell viability increased with increasing concentration of PJ at all time intervals (P<0.001). This effect is suggestive of the proliferative potential of PJ solution. Conclusion: In conclusion, PJ can be recommended as a suitable transport medium for avulsed teeth. PMID:24910699

  12. Use of infrared thermometer technique in irrigation scheduling of pomegranate (Punica granatum L. plant

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    Begüm TEKELİOĞLU

    2017-06-01

    Full Text Available The main objectives of this study are to assess crop water stress index (CWSI and to determine irrigation schedule of pomegranate using infrared thermometer technique. Treatments with three replications were irrigated every three and six days intervals, as much as 0.50 (S1, 0.75 (S2, 1.00 (S3, and 1.25 (S4 of Class A pan evaporation. Additionally, an unirrigated plot was also formed. The equations obtained for non-water stress baseline is Tc-Ta=0.645VPD-4.338. The equation of full water stressed upper baseline obtained from data taken from branches of pomegranate plant cut in different days is given by Tc-Ta= 0.0489VPD+2.8734. According to the results obtained, it is concluded that infrared thermometer can be used for irrigation scheduling of the pomegranate plants in Antalya conditions. When using this technique in Antalya conditions, it is suggested to keep the seasonal mean CWSI value approximately 0.12 and the index value of 0.40 can be used to start the irrigation. Additionally, it is suggested that the amount of irrigation can be determined as much as the amount of evaporation measured until the index value reaches 0.40.

  13. Fatty acids from Tunisian and Chinese pomegranate (Punica granatum L.) seeds.

    Science.gov (United States)

    Elfalleh, Walid; Ying, Ma; Nasri, Nizar; Sheng-Hua, He; Guasmi, Ferdaous; Ferchichi, Ali

    2011-05-01

    Pomegranate seed oil is considered a powerful health-benefiting agent due to its anti-oxidative and anticarcinogenic properties. Lipids from 21 pomegranate cultivars (15 Tunisian and 6 Chinese) were extracted and fatty acids were identified. Total lipids (16% on a dry weight basis) are mainly unsaturated (ca. 88%). Qualitatively, the pomegranate fatty acid composition is identical. Quantitatively, the predominant fatty acid was linolenic acid (44.51-86.14%), followed by linoleic acid (3.57-13.92%), oleic acid (3.03-12.88%), palmitic acid (3.13-11.82%), stearic acid (1.68-15.64%), gadoleic acid (0.50-4.91%), lignoceric acid ( < 2.53%), arachidic acid ( < 1.70%) and myristic acid ( < 0.85%). Statistical methods revealed how Chinese and Tunisian pomegranate fatty acid contents may be affected by the sampling location.

  14. Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture.

    Science.gov (United States)

    Mehta, R; Lansky, E P

    2004-08-01

    We previously reported anticancer effects of pomegranate extracts in human breast cancer cells in vitro and also chemopreventive activity of pomegranate fermented juice polyphenols (W) in a mouse mammary organ culture (MMOC). In the present study we decided to expand the MMOC investigations to also include an evaluation of the potential chemopreventive efficacy of a purified chromatographic peak of W (Peak B), and also of whole pomegranate seed oil. In brief, an MMOC was established according to a known method. For the first 10 days of culture, the glands were treated with pomegranate fermented juice polyphenols (W), a high-performance liquid chromatographic (HPLC) peak separated from W (peak B), or pomegranate seed oil (Oil, and on day 3, exposed to the carcinogen 7,12-dimethylbenz[a]anthracene (DMBA), and for 10 days treated with the putative pomegranate chemopreventive. The glands were subsequently harvested and tumours counted by visual inspection. While W effected a 42% reduction in the number of lesions compared with control, peak B and pomegranate seed oil each effected an 87% reduction. The results highlight enhanced breast cancer preventive potential both for the purified compound peak B and for pomegranate seed oil, both greater than that previously reported for pomegranate fermented juice polyphenols.

  15. Antioxidant capacities of phenolic compounds and tocopherols from Tunisian pomegranate (Punica granatum) fruits.

    Science.gov (United States)

    Elfalleh, Walid; Tlili, Nizar; Nasri, Nizar; Yahia, Yassine; Hannachi, Hédia; Chaira, Nizar; Ying, Ma; Ferchichi, Ali

    2011-01-01

    This article aims to determine the phenolic, tocopherol contents, and antioxidant capacities from fruits (juices, peels, and seed oils) of 6 Tunisian pomegranate ecotypes. Total anthocyanins were determined by a differential pH method. Hydrolyzable tannins were determined with potassium iodate. The tocopherol (α-tocopherol, γ-tocopherol, and δ-tocopherol) contents were, respectively, 165.77, 107.38, and 27.29 mg/100 g from dry seed. Four phenolic compounds were identified and quantified in pomegranate peel and pulp using the high-performance liquid chromatography/ultraviolet method: 2 hydroxybenzoic acids (gallic and ellagic acids) and 2 hydroxycinnamic acids (caffeic and p-coumaric acids). Juice, peel, and seed oil antioxidants were confirmed by ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) methods. The highest values were recorded in peels with 25.63 mmol trolox equivalent/100 g and 22.08 mmol TE/100 g for FRAP and ORAC assay, respectively. Results showed that the antioxidant potency of pomegranate extracts was correlated with their phenolic compound content. In particular, the highest correlation was reported in peels. High correlations were also found between peel hydroxybenzoic acids and FRAP ORAC antioxidant capacities. Identified tocopherols seem to contribute in major part to the antioxidant activity of seed oil. The results implied that bioactive compounds from the peel might be potential resources for the development of antioxidant function dietary food. © 2011 Institute of Food Technologists®

  16. Optimization of ultrasonic-assisted extraction of pomegranate (Punica granatum L.) seed oil.

    Science.gov (United States)

    Tian, Yuting; Xu, Zhenbo; Zheng, Baodong; Martin Lo, Y

    2013-01-01

    The effectiveness of ultrasonic-assisted extraction (UAE) of pomegranate seed oil (PSO) was evaluated using a variety of solvents. Petroleum ether was the most effective for oil extraction, followed by n-hexane, ethyl acetate, diethyl ether, acetone, and isopropanol. Several variables, such as ultrasonic power, extraction temperature, extraction time, and the ratio of solvent volume and seed weight (S/S ratio) were studied for optimization using response surface methodology (RSM). The highest oil yield, 25.11% (w/w), was obtained using petroleum ether under optimal conditions for ultrasonic power, extraction temperature, extraction time, and S/S ratio at 140 W, 40 °C, 36 min, and 10 ml/g, respectively. The PSO yield extracted by UAE was significantly higher than by using Soxhlet extraction (SE; 20.50%) and supercriti cal fluid extraction (SFE; 15.72%). The fatty acid compositions were significantly different among the PSO extracted by Soxhlet extraction, SFE, and UAE, with punicic acid (>65%) being the most dominant using UAE. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. Characterization of constituents, quality and stability of pomegranate seed oil (Punica granatum L.)

    OpenAIRE

    Illana Louise Pereira de MELO; Carvalho,Eliane Bonifácio Teixeira de; Ana Mara de Oliveira e Silva; Luciana Tedesco YOSHIME; Sattler, José Augusto Gasparotto; PAVAN,Rosângela Torres; Mancini-Filho, Jorge

    2016-01-01

    Abstract This study aimed to characterize pomegranate seed oil and evaluate its quality and stability parameters against those of linseed oil. The profile of fatty acids and phytosterols and the content of tocopherols were analyzed by gas chromatography and high performance liquid chromatography, respectively. The quality of both oils was assessed as recommended by the American Oil Chemists' Society (AOCS) and stability was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), β-carotene...

  18. Characterization of constituents, quality and stability of pomegranate seed oil (Punica granatum L.

    Directory of Open Access Journals (Sweden)

    Illana Louise Pereira de MELO

    2016-03-01

    Full Text Available Abstract This study aimed to characterize pomegranate seed oil and evaluate its quality and stability parameters against those of linseed oil. The profile of fatty acids and phytosterols and the content of tocopherols were analyzed by gas chromatography and high performance liquid chromatography, respectively. The quality of both oils was assessed as recommended by the American Oil Chemists' Society (AOCS and stability was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH, β-carotene bleaching (coupled oxidation of β-carotene/linoleic acid and Rancimat® assays. While α-linolenic acid (52% was the most abundant fatty acid in linseed oil (LO, punicic acid (55% was highest in pomegranate seed oil (PSO. Tocopherols and phytosterols (175 and 539 mg/100 g, respectively were greater in PSO than in LO (51 and 328 mg/100 g, respectively. Both oils met quality standards. The β-carotene bleaching and the DPPH assays showed greater oxidative stability for PSO than for LO. The Rancimat® method, on the other hand, indicated low stability for both oils.

  19. CALLUS INDUCTION AND PLANT REGENERATION IN PUNICA GRANATUM L. ?NANA' FROM LEAF EXPLANTS

    Directory of Open Access Journals (Sweden)

    Alireza Bonyanpour

    2013-09-01

    Full Text Available ABSTRACT In this investigation, leaf explants of a local cultivar of dwarf pomegranate were placed on Murashige and Skoog (1962 (MS medium supplemented with various concentrations of 6-benzyl adenin (BA and naphthalene acetic acid (NAA for callus induction. After 40 days, maximum callus induction was observed on a media containing 1 mg L-1 BA and 0.2 to 0.4 mg L-1 NAA. However, the highest callus growth was obtained on a medium containing 1 mg L-1 BA and 1 mg L-1 NAA. The highest number of shoots (7 shoots per explants was obtained by transferring the calli to the media containing 5 mg L-1 BA with 0.1 mg L-1 NAA. Maximum shoot proliferation was observed when shoots were cultured on woody plant medium (WPM supplemented with 5 mg L-1 kinetin (Kin. In this treatment, after 4 subcultures, 36 shoots were produced from one original explant. Among treatments used in rooting experiments, shoots cultured on WPM medium containing 0.2 mg L-1 indol butyric acid (IBA had the maximum root percentage (100% and good root growth (2.06 cm mean length and 2 roots in each explants. Rooted plantlets were cultured in a soil mixture containing vermiculite (60%, perlite (30% and coco peat (10% v/v. After 2 months, 80% of plants survived and transferred to the greenhouse.

  20. OPTIMIZACIÓN DE UNA CERVEZA TIPO LAGER SABORIZADA CON ZUMO DE GRANADA (Punica granatum L.)

    OpenAIRE

    Fuentes Segura, Rosalín Viviana; Universidad Señor de Sipán; Montero Núñez, Delia Marily Yovana; Universidad Señor de Sipán; Morales Cabrera, Liz Amelia Juanitaflor; Universidad Señor de Sipán

    2015-01-01

    El objetivo principal de esta investigación fue optimizar una cerveza tipo lager saborizada con zumo de granada, como alternativa de empleo y valor agregado a esta materia prima que empieza a posicionarse en el mercado internacional, incorporando el zumo en una bebida tan consumida por el mundo como la cerveza tipo lager. Las variables dependientes evaluación de la aceptabilidad del producto final habiendo estudiado en la formulación la concentración de zumo de granada a incorporar durante la...

  1. Pomegranate juice (Punica granatum as an ideal mouthrinse for fixed orthodontic patients

    Directory of Open Access Journals (Sweden)

    Haryono Utomo

    2012-12-01

    Full Text Available Background: Prevention of caries as well as periodontal disease is mandatory during orthodontic treatment. Nevertheless, the use of antiseptic mouthrinse is contraindicated for prolonged use. Pomegranate juice is a polyphenol-rich juice with high antioxidant capacity as well as antimicrobial properties. It has been shown to exert beneficial characteristics for orthodontic patients such as antioxidant and anti inflammatory effects. Moreover, it contained fluoride and phosphorous which are cariostatic. Previous study in fixed orthodontic patients revealed that rinsing with this juice showed reduced dental plaque and superior compared with chlorhexidine. If it has unwanted effect by reducing pro-inflammatory reaction that also needed in orthodontic movement is not clearly understood. Purpose: The aim of the present review was to discuss the beneficial and unwanted effect of pomegranate juice mouthrinse towards orthodontic treatment. Reviews: Pomegranate has antimicrobial activity, its methanolic skin extract is the most potent followed by seed juice. Nevertheless, seed juice is not only tastier, easier to make but also has mild antimicrobial potency which is beneficial for long-term use. Healthy periodontal tissue is preferable for orthodontic movement since it resulted in less unwanted bone resorption. Conclusion: Regarding its beneficial effect and safety of pomegranate juice if use daily mouthrinse in fixed orthodontic patients, it could be proposed as an ideal long term use mouthrinse for fixed orthodontic patients. However, further researches should be done to verify this concept.Latar belakang: Pencegahan karies dan penyakit periodontal sangat penting dalam perawatan ortodontik. Walaupun demikian, penggunaan obat kumur antiseptik jangka panjang merupakan kontraindikasi. Jus buah delima sangat kaya akan polifenol dengan kemampuan antioksidan yang tinggi disertai kemampuan antimikroba. Beberapa penelitian telah menunjukkan dampak menguntungkan pada pasien ortodonti, yaitu sebagai antioksidan dan anti radang. Selain itu juga mengandung fluor dan fosfor yang bersifat kariostatik. Penelitian terdahulu pada pasien ortodonti cekat menunjukkan penurunan plak gigi yang lebih banyak dibanding dengan klorheksidin. Akan tetapi, apakah juga menyebabkan dampak merugikan yaitu mengurangi reaksi keradangan yang juga penting bagi pergerakan ortodonti masih belum jelas. Tujuan: Membahas dampak menguntungkan maupun merugikan jus buah delima pada perawatan ortodonti. Tinjauan pustaka: Buah delima merupakan antimikroba, ekstrak dari kulit yang mengandung metanol adalah paling kuat diikuti jus biji delima. Akan tetapi, jus biji lebih enak rasanya, mudah dibuat dan merupakan antimikroba ringan sehingga menguntungkan untuk pemakaian jangka panjang. Jaringan periodontal yang sehat diperlukan untuk pergerakan ortodonti karena dapat mengurangi resorpsi tulang. Kesimpulan: Berdasarkan dampak menguntungkan dan keamanan jus buah delima bila digunakan tiap hari, bahan ini dapat diusulkan sebagai obat kumur jangka panjang yang ideal untuk pasien ortodonti cekat. Walaupun begitu, penelitian lebih lanjut harus dilakukan untuk verifikasi konsep ini.

  2. Molecular Polymorphisms in Tunisian Pomegranate (Punica granatum L. as Revealed by RAPD Fingerprints

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    Jemni Chibani

    2010-01-01

    Full Text Available The genetic diversity among Tunisian pomegranate cultivars has been investigated. Using universal primers, the random amplified polymorphic DNA (RAPD method was used to generate banding profiles from a set of twelve cultivars. Data was then computed with appropriate programs to construct a dendrogram illustrating the relationships between the studied cultivars. Our data proved the efficiency of the designed method to examine the DNA polymorphism in this crop since the tested primers are characterized by a collective resolving power of 12.83. In addition, the cluster analysis has exhibited a parsimonious tree branching independent from the geographic origin of the cultivars. In spite of the relatively low number of primers and cultivars, RAPD constitutes an appropriate procedure to assess the genetic diversity and to survey the phylogenetic relationships in this crop.

  3. Punica granatum (Pomegranate juice provides an HIV-1 entry inhibitor and candidate topical microbicide

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    Li Yun-Yao

    2004-10-01

    Full Text Available Abstract Background For ≈ 24 years the AIDS pandemic has claimed ≈ 30 million lives, causing ≈ 14,000 new HIV-1 infections daily worldwide in 2003. About 80% of infections occur by heterosexual transmission. In the absence of vaccines, topical microbicides, expected to block virus transmission, offer hope for controlling the pandemic. Antiretroviral chemotherapeutics have decreased AIDS mortality in industrialized countries, but only minimally in developing countries. To prevent an analogous dichotomy, microbicides should be: acceptable; accessible; affordable; and accelerative in transition from development to marketing. Already marketed pharmaceutical excipients or foods, with established safety records and adequate anti-HIV-1 activity, may provide this option. Methods Fruit juices were screened for inhibitory activity against HIV-1 IIIB using CD4 and CXCR4 as cell receptors. The best juice was tested for inhibition of: (1 infection by HIV-1 BaL, utilizing CCR5 as the cellular coreceptor; and (2 binding of gp120 IIIB and gp120 BaL, respectively, to CXCR4 and CCR5. To remove most colored juice components, the adsorption of the effective ingredient(s to dispersible excipients and other foods was investigated. A selected complex was assayed for inhibition of infection by primary HIV-1 isolates. Results HIV-1 entry inhibitors from pomegranate juice adsorb onto corn starch. The resulting complex blocks virus binding to CD4 and CXCR4/CCR5 and inhibits infection by primary virus clades A to G and group O. Conclusion These results suggest the possibility of producing an anti-HIV-1 microbicide from inexpensive, widely available sources, whose safety has been established throughout centuries, provided that its quality is adequately standardized and monitored.

  4. PRE-GERMINATIVE TREATMENTS IN POMEGRANATE SEEDS (Punica granatum L.:EFFECT ON PHYSIOLOGICAL QUALITY

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    JOSEANO GRACILIANO DA SILVA

    Full Text Available ABSTRACT This study aimed to evaluate the efficiency of different removal methods of sarcotesta and their effects on the physiological quality of the seeds. We applied the following treatments: T1 - friction in coarse sand on a sieve; T2 and T3 - immersion in sulfuric acid (98% for 30 minutes and washing in water, with and without a vernalization for 48 hours in a refrigerator at 4 °C, respectively; T4 and T5 - natural fermentation for 72 hours, with seeds submitted and not submitted to drying in shade for seven days; and T6 - seeds with intact sarcotesta as control. The experiment was carried out in a completely randomized design. For the analysis of the viability and vigor, we used the germination test, germination on first count, germination speed index, accelerated aging, emergence test, emergence speed index, number of leaves, plant height, stem diameter, and root length. The data were submitted to analysis of variance and Tukey test. Seeds submitted to fermentation showed the highest germination and emergence values. However, it was not statistically different from the control, probably due to the sensitivity to desiccation or seed dormancy, which was shown in the accelerated aging test.

  5. Bioactive properties of commercialised pomegranate (Punica granatum) juice: antioxidant, antiproliferative and enzyme inhibiting activities.

    Science.gov (United States)

    Les, Francisco; Prieto, Jose M; Arbonés-Mainar, Jose Miguel; Valero, Marta Sofía; López, Víctor

    2015-06-01

    Pomegranate juice and related products have long been used either in traditional medicine or as nutritional supplements claiming beneficial effects. Although there are several studies on this food plant, only a few studies have been performed with pomegranate juice or marketed products. The aim of this work is to evaluate the antioxidant effects of pomegranate juice on cellular models using hydrogen peroxide as an oxidizing agent or DPPH and superoxide radicals in cell free systems. The antiproliferative effects of the juice were measured on HeLa and PC-3 cells by the MTT assay and pharmacologically relevant enzymes (cyclooxygenases, xanthine oxidase, acetylcholinesterase and monoamine oxidase A) were selected for enzymatic inhibition assays. Pomegranate juice showed significant protective effects against hydrogen peroxide induced toxicity in the Artemia salina and HepG2 models; these effects may be attributed to radical scavenging properties of pomegranate as the juice was able to reduce DPPH and superoxide radicals. Moderate antiproliferative activities in HeLa and PC-3 cancer cells were observed. However, pomegranate juice was also able to inhibit COX-2 and MAO-A enzymes. This study reveals some mechanisms by which pomegranate juice may have interesting and beneficial effects in human health.

  6. Antiproliferative and Antiangiogenic Effects of Punica granatum Juice (PGJ in Multiple Myeloma (MM

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    Daniele Tibullo

    2016-10-01

    Full Text Available Multiple myeloma (MM is a clonal B-cell malignancy characterized by an accumulation of clonal plasma cells (PC in the bone marrow (BM leading to bone destruction and BM failure. Despite recent advances in pharmacological therapy, MM remains a largely incurable pathology. Therefore, novel effective and less toxic agents are urgently necessary. In the last few years, pomegranate has been studied for its potential therapeutic properties including treatment and prevention of cancer. Pomegranate juice (PGJ contains a number of potential active compounds including organic acids, vitamins, sugars, and phenolic components that are all responsible of the pro-apoptotic effects observed in tumor cell line. The aim of present investigation is to assess the antiproliferative and antiangiogenic potential of the PGJ in human multiple myeloma cell lines. Our data demonstrate the anti-proliferative potential of PGJ in MM cells; its ability to induce G0/G1 cell cycle block and its anti-angiogenic effects. Interestingly, sequential combination of bortezomib/PGJ improved the cytotoxic effect of the proteosome inhibitor. We investigated the effect of PGJ on angiogenesis and cell migration/invasion. Interestingly, we observed an inhibitory effect on the tube formation, microvessel outgrowth aorting ring and decreased cell migration and invasion as showed by wound-healing and transwell assays, respectively. Analysis of angiogenic genes expression in endothelial cells confirmed the anti-angiogenic properties of pomegranate. Therefore, PGJ administration could represent a good tool in order to identify novel therapeutic strategies for MM treatment, exploiting its anti-proliferative and anti-angiogenic effects. Finally, the present research supports the evidence that PGJ could play a key role of a future therapeutic approach for treatment of MM in order to optimize the pharmacological effect of bortezomib, especially as adjuvant after treatment.

  7. The Roman Hannibal: Remembering the Enemy in Silius Italicus' Punica

    NARCIS (Netherlands)

    Stocks, C.A.

    2014-01-01

    This book offers a new reading of Hannibal in Silius Italicus' Punica and provides fresh insight into how the Romans remembered their past. Silius Italicus' Punica, the longest surviving epic in Latin literature, has seen a resurgence of interest among scholars in recent years. A celebration of

  8. Antimicrobial Analysis of an Antiseptic Made from Ethanol Crude Extracts of P. granatum and E. uniflora in Wistar Rats against Staphylococcus aureus and Staphylococcus epidermidis

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    Thaís Honório Lins Bernardo

    2015-01-01

    Full Text Available Introduction. Surgical site infection remains a challenge for hospital infection control, especially when it relates to skin antisepsis in the surgical site. Objective. To analyze the antimicrobial activity in vivo of an antiseptic from ethanol crude extracts of P. granatum and E. uniflora against Gram-positive and Gram-negative bacteria. Methods. Agar drilling and minimal inhibitory tests were conducted for in vitro evaluation. In the in vivo bioassay were used Wistar rats and Staphylococcus aureus (ATCC 25923 and Staphylococcus epidermidis (ATCC 14990. Statistical analysis was performed through variance analysis and Scott-Knott cluster test at 5% probability and significance level. Results. In the in vitro, ethanolic extracts of Punica granatum and Eugenia uniflora and their combination showed the best antimicrobial potential against S. epidermidis and S. aureus. In the in vivo bioassay against S. epidermidis, there was no statistically significant difference between the tested product and the patterns used after five minutes of applying the product. Conclusion. The results indicate that the originated product is an antiseptic alternative source against S. epidermidis compared to chlorhexidine gluconate. It is suggested that further researches are to be conducted in different concentrations of the test product, evaluating its effectiveness and operational costs.

  9. Antimicrobial Analysis of an Antiseptic Made from Ethanol Crude Extracts of P. granatum and E. uniflora in Wistar Rats against Staphylococcus aureus and Staphylococcus epidermidis.

    Science.gov (United States)

    Bernardo, Thaís Honório Lins; Sales Santos Veríssimo, Regina Célia; Alvino, Valter; Silva Araujo, Maria Gabriella; Evangelista Pires dos Santos, Raíssa Fernanda; Maurício Viana, Max Denisson; de Assis Bastos, Maria Lysete; Alexandre-Moreira, Magna Suzana; de Araújo-Júnior, João Xavier

    2015-01-01

    Surgical site infection remains a challenge for hospital infection control, especially when it relates to skin antisepsis in the surgical site. To analyze the antimicrobial activity in vivo of an antiseptic from ethanol crude extracts of P. granatum and E. uniflora against Gram-positive and Gram-negative bacteria. Agar drilling and minimal inhibitory tests were conducted for in vitro evaluation. In the in vivo bioassay were used Wistar rats and Staphylococcus aureus (ATCC 25923) and Staphylococcus epidermidis (ATCC 14990). Statistical analysis was performed through variance analysis and Scott-Knott cluster test at 5% probability and significance level. In the in vitro, ethanolic extracts of Punica granatum and Eugenia uniflora and their combination showed the best antimicrobial potential against S. epidermidis and S. aureus. In the in vivo bioassay against S. epidermidis, there was no statistically significant difference between the tested product and the patterns used after five minutes of applying the product. The results indicate that the originated product is an antiseptic alternative source against S. epidermidis compared to chlorhexidine gluconate. It is suggested that further researches are to be conducted in different concentrations of the test product, evaluating its effectiveness and operational costs.

  10. Environ: E00379 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available E00379 Punica granatum fruit peel Crude drug Tannin, Mucilaginous Punica granatum [...TAX:22663] Lythraceae (loosestrife family) Punica granatum mature fruit peel Crude drugs [BR:br08305] Dicot ...plants: rosids Lythraceae (loosestrife family) E00379 Punica granatum fruit peel ...

  11. Inhibition of Listeria monocytogenes by pomegranate (Punica granatum) peel extract in meat paté at different temperatures

    NARCIS (Netherlands)

    Hayrapetyan, H.; Hazeleger, W.C.; Beumer, R.R.

    2012-01-01

    Natural antimicrobials are being more and more considered as alternative approach for controlling growth of microorganisms in food. The objective of this study was to evaluate the pomegranate extract’s (PE) potential to be used as a natural preservative in ready to eat meats. Listeria monocytogenes

  12. Antioxidant and Anti-Inflammatory Activities of Pomegranate (Punica granatum on Eimeria papillata-Induced Infection in Mice

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    Omar S. O. Amer

    2015-01-01

    Full Text Available Coccidiosis is the most prevalent disease causing widespread economic loss, especially in poultry farms. Here, we investigated the effects of pomegranate peel extract (PPE on the outcome of coccidiosis caused by Eimeria papillata in mice. The data showed that mice infected with E. papillata and treated with PPE revealed a significant decrease in the output of oocysts in their faeces by day 5 p.i. Infection also induced inflammation and injury of the jejunum. This was evidenced (i as increases in reactive oxygen species, (ii, as increased neutrophils and decreased lymphocytes in blood (ii as increased mRNA levels of inducible nitric oxide synthase (iNOS, Bcl-2 gene, and of the cytokines interferon gamma (IFN-γ, tumour necrosis factor-α (TNF-α, and interleukin-1β (IL-1β, and (iv as downregulation of mucin gene MUC2 mRNA. All these infection-induced parameters were significantly altered during PPE treatment. In particular, PPE counteracted the E. papillata-induced loss of the total antioxidant capacity. Our data indicated that PPE treatment significantly attenuated inflammation and injury of the jejunum induced by E. papillata infections.

  13. Effect of different coatings on post-harvest quality and bioactive compounds of pomegranate (Punica granatum L.) fruits.

    Science.gov (United States)

    Meighani, Hossein; Ghasemnezhad, Mahmood; Bakhshi, Davood

    2015-07-01

    The effect of three different coatings; resin wax (Britex Ti), carnauba wax (Xedasol M14), and chitosan (1 and 2 % w/v) on postharvest quality of pomegranate fruits were investigated. Fruits quality characteristics and bioactive compounds were evaluated during 40, 80 and 120 days storage at 4.5 °C and 3 additional days at 20 °C. The results showed that uncoated fruits showed higher respiration rate, weight loss, L* and b* values of arils, total soluble solids (TSS)/titratable acidity (TA), and pH than coated fruits during storage. Coating treatments could delay declining TSS and TA percent, a* value of arils, as well as bioactive compounds such as total phenolics, flavonoids and anthocyanins content and antioxidant activity. The coated fruits with commercial resin and carnauba waxes showed significantly lower respiration rate and weight loss than other treatments, however carnauba wax could maintain considerably higher fruits quality and bioactive compounds than other coating treatments. The results suggested that postharvest application of carnauba wax have a potential to extend storage life of pomegranate fruits by reducing respiration rate, water loss and maintaining fruit quality.

  14. Assessment of Genetic Variation within Commercial Iranian Pomegranate (Punica granatum L. Cultivars, Using ISSR and SSR Markers

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    Meysam Madadi

    2017-07-01

    Full Text Available Pomegranate is one of the most important horticultural crops in Iran, and has been cultivated for thousands of years in this country. At this period due to selection of superior cultivars from nature or mutation emerged in these cultivars, and their vegetative propagation, substantial genetic variation has occurred within and among the cultivars. Thus, each cultivar may consist of different clones. According to this issue, diversity within four commercial cultivars of pomegranate was analyzed. Two molecular marker systems including ISSR and SSR were used to evaluate variability between 36 samples of four commercial cultivars. ISSR markers produced 114 amplification products, out of which 97 were polymorphic (83.23%. Mean resolving power was 2.96 for ISSR markers. 19 SSR molecular markers were used, 15 of which amplified polymorphic products, while the remaining ones monomorphic., The number of polymorphic alleles per locus ranged from two to four (average 3.6. The observed and expected heterozygosities ranged from 0.04 to 0.92 and 0.14 to 0.62, respectively. In addition, mean polymorphic information content was 0.45 for SSR loci. Our results showed that commercial Iranian pomegranate have different clones. Therefore, ISSR and SSR markers can be a useful tools for detecting clones of each cultivar.

  15. Incidence and etiology of postharvest fungal diseases of pomegranate (Punica granatum cv. Mollar de Elche in Spain

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    Lluís PALOU

    2014-01-01

    Full Text Available Spain is the largest European Union producer and exporter of pomegranates. More than 85% of Spanish commercial plantings are located in the Elche area (Alicante Province, SE Spain, where cv. Mollar de Elche is the most important cultivar. The incidence and etiology of postharvest pomegranate diseases were determined in local environmental conditions. Commercially-grown pomegranates cv. Mollar de Elche from two orchards were assessed, during two consecutive seasons, for latent and wound pathogens causing postharvest diseases. Healthy pomegranates were either artificially wounded in the rind or surface disinfected and placed in humid chambers at 20ºC for up to 15 weeks. Additionally, decay was periodically assessed on commercially-handled pomegranates stored at 5ºC for up to 27 weeks. The main causal agents of wound and latent infections were Penicillium spp. and Botrytis cinerea, respectively. The same pathogens were also the most frequently isolated from cold-stored fruit, but decay at 5ºC was only significant after 19 weeks. Another relatively frequent pathogen on fruit incubated at 20ºC was Aspergillus niger. Among the fungi isolated, Penicillium expansum, P. sclerotiorum, P. glabrum and Pilidiella granati were pathogenic on inoculated pomegranates, whereas P. minioluteum and Cytospora annulata were not. No decay caused by Alternaria spp. or Colletotrichum gloeosporioides was observed.

  16. Nanoscaled Electrocatalytic Optically Modulated ZnO Nanoparticles through Green Process of Punica granatum L. and Their Antibacterial Activities

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    Xolile Fuku

    2016-01-01

    Full Text Available Most recently, green synthesis of metal oxide nanoparticles has become an interesting subject of the nanoscience and nanotechnology. The use of plant systems has been deemed a green route and a dependable method for nanoparticle biosynthesis, owing to its environmental friendly nature. The present work demonstrates the bioreductive green synthesis of nanosized zinc oxide (ZnO using peel extracts of pomegranate. Highly crystalline ZnO nanoparticles (ZnO NPs which are 5 nm in particle size were characterised by HRTEM and XRD. FT-IR spectra confirmed the presence of the biomolecules and formation of plant protein-coated ZnO NPs and also the pure ZnO NPs. Electrochemical investigation revealed the redox properties and the conductivity of the as-prepared ZnO nanoparticles. The optical band gap of ZnO NPs was calculated to be 3.48 eV which indicates that ZnO NPs can be used in metal oxide semiconductor-based devices. Further, the nanomaterials were also found to be good inhibitors of bacterial strains at both low and high concentrations of 5–10 mg mL−1.

  17. Anti-inflammatory activity of Punica granatum L. (Pomegranate) rind extracts applied topically to ex vivo skin.

    Science.gov (United States)

    Houston, David M J; Bugert, Joachim; Denyer, Stephen P; Heard, Charles M

    2017-03-01

    Coadministered pomegranate rind extract (PRE) and zinc (II) produces a potent virucidal activity against Herpes simplex virus (HSV); however, HSV infections are also associated with localised inflammation and pain. Here, the objective was to determine the anti-inflammatory activity and relative depth penetration of PRE, total pomegranate tannins (TPT) and zinc (II) in skin, ex vivo. PRE, TPT and ZnSO 4 were dosed onto freshly excised ex vivo porcine skin mounted in Franz diffusion cells and analysed for COX-2, as a marker for modulation of the arachidonic acid inflammation pathway, by Western blotting and immunohistochemistry. Tape stripping was carried out to construct relative depth profiles. Topical application of PRE to ex vivo skin downregulated expression of COX-2, which was significant after just 6h, and maintained for up to 24h. This was achieved with intact stratum corneum, proving that punicalagin penetrated skin, further supported by the depth profiling data. When PRE and ZnSO 4 were applied together, statistically equal downregulation of COX-2 was observed when compared to the application of PRE alone; no effect followed the application of ZnSO 4 alone. TPT downregulated COX-2 less than PRE, indicating that tannins alone may not be entirely responsible for the anti-inflammatory activity of PRE. Punicalagin was found throughout the skin, in particular the lower regions, indicating appendageal delivery as a significant route to the viable epidermis. Topical application of TPT and PRE had significant anti-inflammatory effects in ex vivo skin, confirming that PRE penetrates the skin and modulates COX-2 regulation in the viable epidermis. Pomegranates have potential as a novel approach in ameliorating the inflammation and pain associated with a range of skin conditions, including cold sores and herpetic stromal keratitis. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Chitinase III in pomegranate seeds (Punica granatum Linn.): a high-capacity calcium-binding protein in amyloplasts.

    Science.gov (United States)

    Yang, Haixia; Zhang, Tuo; Masuda, Taro; Lv, Chenyan; Sun, Lei; Qu, Guiqin; Zhao, Guanghua

    2011-12-01

    Chitinases are a class of ubiquitous proteins that are widely distributed in plants. Defense is the major natural role for chitinases, primarily against fungal pathogens. Little is known regarding their non-defensive roles in seeds. In this study, a new class III chitinase from pomegranate seeds (pomegranate seed chitinase, PSC) was isolated and purified to homogeneity. The native state of PSC is a monomer with a molecular weight of approximately 30 kDa. This chitinase naturally binds calcium ions with high capacity and low affinity, suggesting that PSC is a calcium storage protein. Consistent with this idea, its amino acid sequence (inferred from cDNA) is rich in acidic amino acid residues, especially Asp, similar to reported calcium storage proteins. The presence of calcium considerably improves the stability of the protein but has little effect on its enzymatic activity. Transmission electron microscopy analyses indicate that, similar to phytoferritin, this enzyme is widely distributed in the stroma of amyloplasts of the embryonic cells, suggesting that amyloplasts in seeds could serve as an alternative plastid for calcium storage. Indeed, the transmission electron microscopy results showed that, within the embryonic cells, calcium ions are mainly distributed in the stroma of the amyloplasts, consistent with a role for PSC in calcium storage. Thus, the plant appears to have evolved a new plastid for calcium storage in seeds. During seed germination, the content of this enzyme decreases with time, suggesting that it is involved in the germination process. © 2011 The Authors. The Plant Journal © 2011 Blackwell Publishing Ltd.

  19. Inhibitory effect of a novel combination of Salvia hispanica (chia) seed and Punica granatum (pomegranate) fruit extracts on melanin production.

    Science.gov (United States)

    Diwakar, Ganesh; Rana, Jatinder; Saito, Lisa; Vredeveld, Doug; Zemaitis, Dorothy; Scholten, Jeffrey

    2014-09-01

    In recent years, dietary fatty acids have been extensively evaluated for nutritional as well as cosmetic benefits. Among the dietary fats, the omega-3 (ω3) and omega-6 (ω6) forms of polyunsaturated fatty acids (PUFAs) have been found to exhibit many biological functions in the skin such as prevention of transepidermal water loss, maintenance of the stratum corneum epidermal barrier, and disruption of melanogenesis in epidermal melanocytes. In this study, we examined the effect of chia seed extract, high in ω3 (linolenic acid) and ω6 (linoleic acid) PUFAs, for its capacity to affect melanogenesis. Chia seed extract was shown to inhibit melanin biosynthesis in Melan-a cells; however, linoleic and α-linolenic acids alone did not effectively reduce melanin content. Further investigation demonstrated that chia seed extract in combination with pomegranate fruit extract had a synergistic effect on the inhibition of melanin biosynthesis with no corresponding effect on tyrosinase activity. Investigation of the possible mechanism of action revealed that chia seed extract downregulated expression of melanogenesis-related genes (Tyr, Tyrp1, and Mc1r), alone and in combination with pomegranate fruit extract, suggesting that the inhibition of melanin biosynthesis by a novel combination of chia seed and pomegranate fruit extracts is possibly due to the downregulation of gene expression of key melanogenic enzymes. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. Fermentative preparation of functional drink from Punica granatum using lactic acid bacteria and exploring its anti-tumor potential

    Science.gov (United States)

    Murthy, Shruthi N.; Patnaik, Amie; Srinivasan, Nandini; Selvarajan, E.; Nivetha, A.; Mohanasrinivasan, V.

    2017-11-01

    In the present research work probiotic pomegranate juice production by fermentation was carried out using two different strains such as Lactobacillus plantarum VITES07 and Lactobacillus acidophilus NCIM2903 (Lactic acid bacteria). Fermented pomegranate juice was carried out at room temperature for 72h. During the fermentation period at regular intervals viable cells was determined. Efficiency of the fermented juice was analysed for 4 weeks under refrigerated condition at 4˚C. Total phenolics, sugar concentration, antioxidant potential, and antibacterial activity were determined. Organic acid concentration was determined by HPLC with retention time of a compound at 9.1 can be suspected to be Kaempferol hexoside and functional group was determined by FTIR also LCMS analysis was carried out to enumerate the chemical composition of the fermented juice.

  1. Antioxidant and Anti-Inflammatory Activities of Pomegranate (Punica granatum) on Eimeria papillata-Induced Infection in Mice

    Science.gov (United States)

    Amer, Omar S. O.; Dkhil, Mohamed A.; Hikal, Wafaa M.

    2015-01-01

    Coccidiosis is the most prevalent disease causing widespread economic loss, especially in poultry farms. Here, we investigated the effects of pomegranate peel extract (PPE) on the outcome of coccidiosis caused by Eimeria papillata in mice. The data showed that mice infected with E. papillata and treated with PPE revealed a significant decrease in the output of oocysts in their faeces by day 5 p.i. Infection also induced inflammation and injury of the jejunum. This was evidenced (i) as increases in reactive oxygen species, (ii), as increased neutrophils and decreased lymphocytes in blood (ii) as increased mRNA levels of inducible nitric oxide synthase (iNOS), Bcl-2 gene, and of the cytokines interferon gamma (IFN-γ), tumour necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), and (iv) as downregulation of mucin gene MUC2 mRNA. All these infection-induced parameters were significantly altered during PPE treatment. In particular, PPE counteracted the E. papillata-induced loss of the total antioxidant capacity. Our data indicated that PPE treatment significantly attenuated inflammation and injury of the jejunum induced by E. papillata infections. PMID:25654088

  2. Facile synthesis of size-tunable gold nanoparticles by pomegranate (Punica granatum) leaf extract: Applications in arsenate sensing

    Energy Technology Data Exchange (ETDEWEB)

    Rao, Ashit; Mahajan, Ketakee; Bankar, Ashok [Institute of Bioinformatics and Biotechnology, University of Pune, Pune 411007 (India); Srikanth, Rapole [Proteomics Laboratory, National Centre for Cell Science, Pune 411007 (India); Kumar, Ameeta Ravi [Institute of Bioinformatics and Biotechnology, University of Pune, Pune 411007 (India); Gosavi, Suresh, E-mail: swg@physics.unipune.ac.in [Department of Physics, University of Pune, Pune 411007 (India); Centre for Sensor Studies, University of Pune, Pune 411007 (India); Zinjarde, Smita, E-mail: smita@unipune.ac.in [Institute of Bioinformatics and Biotechnology, University of Pune, Pune 411007 (India); Centre for Sensor Studies, University of Pune, Pune 411007 (India)

    2013-03-15

    Highlights: ► Pomegranate leaf extracts mediated rapid gold nanoparticle (AuNP) synthesis. ► The phyto-inspired AuNPs were size-tuned and characterized. ► The reducing and capping agents in the extract were identified. ► The nanoparticles reacted specifically with arsenate (V) ions. - Abstract: When pomegranate leaf extracts were incubated with chloroauric acid (HAuCl{sub 4}), gold nanoparticles (AuNPs) were synthesized. These were characterized by a variety of techniques. With an increasing content of the leaf extract, a gradual decrease in size and an increase in monodispersity were observed. Transmission electron microscope (TEM) images showed that the phyto-fabricated AuNPs were surrounded by an amorphous layer. Gallic acid in the extract mediated the reduction and a natural decapeptide capped the nanostructures. Blocking of thiol groups in the decapeptide cysteine residues caused the nanoparticles to aggregate. On interaction with arsenate (V) ions, the UV–vis spectra of the nanoparticles showed a decrease in intensity and a red-shift. Energy dispersive spectra confirmed the presence of arsenate associated with the AuNPs. Thus, by using these AuNPs, a method for sensing the toxic arsenate ions could be developed.

  3. Preparation and antibacterial activities of Ag/Ag+/Ag3+ nanoparticle composites made by pomegranate (Punica granatum) rind extract

    Science.gov (United States)

    Yang, Hui; Ren, Yan-yu; Wang, Tao; Wang, Chuang

    Nano-silver and its composite materials are widely used in medicine, food and other industries due to their strong conductivity, size effect and other special performances. So far, more microbial researches have been applied, but a plant method is rarely reported. In order to open up a new way to prepare AgNP composites, pomegranate peel extract was used in this work to reduce Ag+ to prepare Ag/Ag+/Ag3+ nanoparticle composites. UV-Vis was employed to detect and track the reduction of Ag+ and the forming process of AgNPs. The composition, structure and size of the crystal were analyzed by XRD and TEM. Results showed that, under mild conditions, pomegranate peel extract reacted with dilute AgNO3 solution to produce Ag/Ag+/Ag3+ nanoparticle composites. At pH = 8 and 10 mmol/L of AgNO3 concentration, the size of the achieved composites ranged between 15 and 35 nm with spherical shapes and good crystallinity. The bactericidal experiment indicated that the prepared Ag/Ag+/Ag3+ nanoparticles had strong antibacterial activity against gram positive bacteria and gram negative bacteria. FTIR analysis revealed that biological macromolecules with groups of sbnd NH2, sbnd OH, and others were distributed on the surface of the newly synthesized Ag/Ag+/Ag3+ nanoparticles. This provided a useful clue to further study the AgNP biosynthesis mechanism.

  4. Genome-wide identification of microRNAs in pomegranate (Punica granatum L.) by high-throughput sequencing.

    Science.gov (United States)

    Saminathan, Thangasamy; Bodunrin, Abiodun; Singh, Nripendra V; Devarajan, Ramajayam; Nimmakayala, Padma; Jeff, Moersfelder; Aradhya, Mallikarjuna; Reddy, Umesh K

    2016-05-26

    MicroRNAs (miRNAs), a class of small non-coding endogenous RNAs that regulate gene expression post-transcriptionally, play multiple key roles in plant growth and development and in biotic and abiotic stress response. Knowledge and roles of miRNAs in pomegranate fruit development have not been explored. Pomegranate, which accumulates a large amount of anthocyanins in skin and arils, is valuable to human health, mainly because of its antioxidant properties. In this study, we developed a small RNA library from pooled RNA samples from young seedlings to mature fruits and identified both conserved and pomegranate-specific miRNA from 29,948,480 high-quality reads. For the pool of 15- to 30-nt small RNAs, ~50 % were 24 nt. The miR157 family was the most abundant, followed by miR156, miR166, and miR168, with variants within each family. The base bias at the first position from the 5' end had a strong preference for U for most 18- to 26-nt sRNAs but a preference for A for 18-nt sRNAs. In addition, for all 24-nt sRNAs, the nucleotide U was preferred (97 %) in the first position. Stem-loop RT-qPCR was used to validate the expression of the predominant miRNAs and novel miRNAs in leaves, male and female flowers, and multiple fruit developmental stages; miR156, miR156a, miR159a, miR159b, and miR319b were upregulated during the later stages of fruit development. Higher expression of miR156 in later fruit developmental may positively regulate anthocyanin biosynthesis by reducing SPL transcription factor. Novel miRNAs showed variation in expression among different tissues. These novel miRNAs targeted different transcription factors and hormone related regulators. Gene ontology and KEGG pathway analyses revealed predominant metabolic processes and catalytic activities, important for fruit development. In addition, KEGG pathway analyses revealed the involvement of miRNAs in ascorbate and linolenic acid, starch and sucrose metabolism; RNA transport; plant hormone signaling pathways; and circadian clock. Our first and preliminary report of miRNAs will provide information on the synthesis of biochemical compounds of pomegranate for future research. The functions of the targets of the novel miRNAs need further investigation.

  5. Pomegranate ( Punica granatum L.) expresses several nsLTP isoforms characterized by different immunoglobulin E-binding properties.

    Science.gov (United States)

    Bolla, Michela; Zenoni, Sara; Scheurer, Stephan; Vieths, Stefan; San Miguel Moncin, Maria Del Mar; Olivieri, Mario; Antico, Andrea; Ferrer, Marta; Berroa, Felicia; Enrique, Ernesto; Avesani, Linda; Marsano, Francesco; Zoccatelli, Gianni

    2014-01-01

    Pomegranate allergy is associated with sensitization to non-specific lipid transfer proteins (nsLTPs). Our aim was to identify and characterize the non-specific nsLTPs expressed in pomegranate at the molecular level and to study their allergenic properties in terms of immunoglobulin E (IgE)-binding and cross-reactivity with peach nsLTP (Pru p 3). A non-equilibrium two-dimensional (2-D) electrophoretic approach based on acid-urea PAGE and sodium dodecyl sulfate PAGE was set up to separate pomegranate nsLTPs. Their immunoreactivity was tested by immunoblotting carried out with anti-Pru p 3 polyclonal antibodies and sera from pomegranate-allergic patients. For final identification, pomegranate nsLTPs were purified by chromatography and subjected to trypsin digestion and mass spectrometry (MS) analysis. For this purpose, the sequences obtained by cDNA cloning of three pomegranate nsLTPs were integrated in the database that was subsequently searched for MS data interpretation. Four nsLTPs were identified by 2-D immunoblotting. The detected proteins showed different IgE-binding capacity and partial cross-reactivity with Pru p 3. cDNA cloning and MS analyses led to the identification of three nsLTP isoforms with 66-68% amino acid sequence identity named Pun g 1.0101, Pun g 1.0201 and Pun g 1.0301. By 2-D electrophoresis, we could separate different nsLTP isoforms possessing different IgE-binding properties, which might reflect peculiar allergenic potencies. The contribution of Pru p 3 to prime sensitization is not central as in other plant nsLTPs. © 2014 S. Karger AG, Basel.

  6. Molecular detection and characterization of Hop stunt viroid sequence variants from naturally infected pomegranate (Punica granatum L. in Tunisia

    Directory of Open Access Journals (Sweden)

    Faten GORSANE

    2010-09-01

    Full Text Available Tunisian pomegranate Hop stunt viroid (HSVd variants are described. Dot-blot hybridization, S-Page, and reverse transcription polymerase chain reaction (RT-PCR of RNA extracts from infected tissues were carried out. Results obtained by these techniques were confirmed by cDNA sequencing. The genetic diversity among the Tunisian variants was investigated, which also involved analysis of sequences of previously described HSVd variants from Tunisian citrus var. clementine and fig, and from fruit trees from other Mediterranean countries. Phylogenetic analysis showed that Tunisian pomegranate HSVd variants were clustered into two groups: a cachexia strain within the citrus type group and a recombinant citrus-plum type group. Results also showed a high haplotype diversity which was not related either to the host or to the geographical origin. Selective neutrality and genetic network tests suggest that the HSVd isolates have spread rapidly.

  7. Effect of Punica granatum fruit peel on glucose-6-phosphate dehydrogenase and malate dehydrogenase in amphistome Gastrothylax indicus

    National Research Council Canada - National Science Library

    Aggarwal, Rama; Bagai, Upma

    2017-01-01

    ...) show subcellular distribution pattern. Activity of G-6-PDH was largely restricted to cytosolic fraction while MDH was found in both cytosolic and mitochondrial fraction in Gastrothylax indicus...

  8. Physicochemical properties and aroma volatile profiles in a diverse collection of California-grown pomegranate (Punica granatum L.) germplasm

    Science.gov (United States)

    There are thousands of pomegranate accessions and more than 500 known pomegranate cultivars with around 50 available commercially, exhibiting different growing characteristics and quality attributes; such as fruit size, color, shape, seed hardness, taste and flavor traits which are sometimes not wel...

  9. Pomegranate (Punica granatum Peel Extract as a Green Corrosion Inhibitor for Mild Steel in Hydrochloric Acid Solution

    Directory of Open Access Journals (Sweden)

    Habib Ashassi-Sorkhabi

    2015-01-01

    Full Text Available The inhibition effect of pomegranate peel extract (PPE on the corrosion of mild steel in hydrochloric acid (HCl solution was investigated. The polarization, mass loss, and electrochemical impendence techniques were used to evaluate the corrosion inhibition performance of the pomegranate peel extract. The results revealed that PPE acts as a corrosion inhibitor in HCl solution. The inhibition efficiency increased with the increase of extract concentration. The inhibition action was attributed to the adsorption of the chemical compounds present in the extract solution, on mild steel surface.

  10. Screening Marker Components Of Tyrosinase Inhibitor From Xylocarpus Granatum Stem

    Directory of Open Access Journals (Sweden)

    Latifah K Darusman

    2017-03-01

    Full Text Available The aim of our research was to screen the marker components of tyrosinase inhibitor from Xylocarpus granatum stem collected from Pulau Sebuku, South Kalimantan, Indonesia.  The screening method started from selection of part of X. granatum, stem or stem bark.  Stem and stem bark of X. granatum were dried and grounded before submitted to methanol.  The stem extracts is more potent as tyrosinase inhibitor (IC50 for monophenolase is 45.12 μg/ml and diphenolase is 31.59μg/ml compared to the bark extracts. The IC50 values of kojic acid as positive control are 17.43μg/ml for monophenolase and 20.69 μg/ml for diphenolase. The stem extract then separated with silica gel column chromatography and preparative thin layer chromatography.  The results showed that component with Rf 0,25 and 0.63 (TLC analysis with stationary phase silica gel GF254 and mobile phase ethyl acetic: methanol (8:2 are the marker components as tyrosinase inhibitor for X. granatum.

  11. Biological studies of Oligonychus punicae (Acari: Tetranychidae) on grapevine cultivars.

    Science.gov (United States)

    Vásquez, Carlos; Aponte, Orlando; Morales, José; Sanabria, María E; García, Grisaly

    2008-06-01

    Life cycle, fecundity and longevity of the avocado brown mite, Oligonychus punicae (Hirst), were studied on six grapevine cultivars (Tucupita, Villanueva, Red Globe, Sirah, Sauvignon and Chenin Blanc), under laboratory conditions at 27 +/- 2 degrees C, 80 +/- 10% RH, and L12:D12 photoperiod. Mite-infested leaves were collected from vineyards, placed in paper bags and taken to the laboratory. A laboratory mite culture was established using the grape cultivar Criolla Negra as host plant. To elucidate potential effects on avocado brown mite parameters, we assessed levels of secondary metabolites, such as alkaloids, flavonoids, tannins and polyphenols, of leaves of the six grape cultivars, as well as the thickness of the adaxial cuticle-epidermis. The life cycle of O. punicae differed among cultivars with average values ranging between 8.2 days on Tucupita leaves and 9.1 days on Sirah. Relatively high fecundity was found on Tucupita leaves (2.8 eggs/female/day) during 11.4 oviposition days, while low fecundity values occurred on Sirah and Villanueva leaves, with 0.9 and 1.8 eggs/female/day during 7.9 and 6.7 days, respectively. Average longevity of O. punicae females ranged from 8.1 to 17.5 days on Sirah and Sauvignon leaves, respectively. Intrinsic rate of increase (r (m)) was highest on Sauvignon (0.292) and Tucupita (0.261), and lowest on Sirah (0.146) and Villanueva (0.135). Although significant differences in cuticle-epidermis thickness were detected among the six cultivars, it seemed not to affect mite parameters. Secondary metabolite content also varied between the cultivars. Generally, increasing flavonoid content coincided with decreasing reproductive parameters. The natural plant resistance observed in this study could be useful in the development of an integrated pest management program for mite pests in grape production.

  12. Environ: E00495 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available E00495 Punica granatum bark or root bark Granati cortex Gratati radix cortex Crude ...ceae (loosestrife family) Punica granatum bark or root bark (dried) Crude drugs [...BR:br08305] Dicot plants: rosids Lythraceae (loosestrife family) E00495 Punica granatum bark or root bark ...

  13. Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis.

    Science.gov (United States)

    Kim, Hyemee; Banerjee, Nivedita; Ivanov, Ivan; Pfent, Catherine M; Prudhomme, Kalan R; Bisson, William H; Dashwood, Roderick H; Talcott, Stephen T; Mertens-Talcott, Susanne U

    2016-09-01

    Tannin-rich fruits have been evaluated as alternative prevention strategies for colorectal cancer based on their anti-inflammatory properties. This study compared tannin-rich preparations from mango (rich in gallotannins) and pomegranate (rich in ellagitannins) in the dextran sodium sulfate-induced colitis model. In rats, mango and pomegranate beverages decreased intestinal inflammation and the levels of pro-inflammatory cytokines in mucosa and serum. The mango beverage suppressed the ratio of phosphorylated/total protein expression of the IGF-1R-AKT/mTOR axis and downregulated mRNA expression of Igf1, Insr, and pik3cv. Pomegranate decreased p70S6K and RPS6, as well as Rps6ka2, Map2k2, and Mapk1 mRNA. In silico modeling indicated a high binding of docked of gallic acid to the catalytic domain of IGF-1R, which may suppress the activity of the enzyme. Ellagic acid docked effectively into the catalytic domains of both IGF-1R and EGFR. In vitro assays with lipopolysaccharide-treated CCD-18Co cells using polyphenolic extracts from each beverage, as well as pure compounds, corroborated the predictions made in silico. Mango polyphenols inhibited the IGF-1R- AKT/mTOR axis, and pomegranate polyphenols downregulate the mTOR downstream pathway through reductions in ERK1/2. These results suggest that extracts rich in gallo- and ellagitannins act on different molecular targets in the protection against ulcerative colitis. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Optimisation of Microwave-Assisted Extraction of Pomegranate (Punica granatum L.) Seed Oil and Evaluation ���of Its Physicochemical and Bioactive Properties

    OpenAIRE

    Hasene Keskin Çavdar; Uğur Gök; Fahrettin Göğüş; Derya Koçak Yanık

    2017-01-01

    Pomegranate seed oil was extracted in a closed-vessel high-pressure microwave system. The characteristics of the obtained oil, such as fatty acid composition, free fatty acidity, total phenolic content, antioxidant activity and colour, were compared to those of the oil obtained by cold solvent extraction. Response surface methodology was applied to optimise extraction conditions: power (176���300 W), time (5���20 min), particle size (d=0.125���0.800 mm) and solvent to sample ratio (2:1, 6:1 a...

  15. The inhibition of malignant epithelial cells in mucosal injury in the oral cavity of strains by pomegranate fruit extract (Punica granatum linn through Bcl-2 expression

    Directory of Open Access Journals (Sweden)

    Sri Hernawati

    2013-03-01

    Full Text Available Background: Squamous cell carcinoma of oral cavity is a malignant neoplasms derived from epithelia. The malignant neoplasms are cells that have changed their structure and function, and their number becomes increasing abnormally, invasive, and metastatic. Carcinoma can be caused by the resistance of malignant cell apoptosis. Bcl-2 is a proto-oncogene of Bcl family that inhibits the process of cell apoptosis and suppresses Bax protein (pro-apoptotic. The management efforts of cancer diseases, however, still have many obstacles. Thus, the researcher was triggered to explore more herbal plants, namely pomegranate. Pomegranate as a medicinal plant is accessible and cheap. Ellagic acid (EA is a single active compound derived from whole pomegranate fruit extract (PGL, which has anti-cancer activity as in vitro, but EA is low concentration in plasma, low water solubility, and insoluble in intestinal. These facts prompted the researcher to compare between pomegranate extract, which consists of several active compounds, and that, which only consists of ellagic acid. Thus, this research is expected to know how some active compounds can work synergistically in the PGL, so the effect can be more potent. Purpose: The purpose of this research, therefore, was to compare EA with PGL in reducing the expression of Bcl-2. Methods: This laboratory experimental research was used 32 male mice (Balb/c in the age of 5 months. They were randomly divided into 4 groups: 2 control groups (K0: which was not exposed with benzopirene and also untreated and K1: which was exposed with benzopirene and also untreated, 2 treatment groups (P1: which was exposed with benzopirene and also treated with EA and P2: which was exposed with benzopirene and also treated with the PGL. Next, an examination was conducted by using immunohistochemical techniques. results: The results then showed that the provision of the PGL could decrease the expression of Bcl-2 significantly higher than that of EA in the malignant epithelial cells of the oral mucosa of those mice. Conclusion: It may be concluded that the provision of the PGL can kill malignant cells in the oral cavity of mice by increasing apoptosis through decreasing Bcl-2 expression that was higher than the provision of EA.latar belakang: Karsinoma sel skuamosa rongga mulut adalah istilah yang digunakan menyebut neoplasma ganas berasal dari epitel. Neoplasma ganas adalah sel yang telah berubah struktur dan fungsi, sehingga mengalami peningkatan jumlah secara abnormal,invasif dan metastasis. Terjadinya karsinoma salah satu disebabkan oleh karena hambatan apoptosis terhadap sel ganas. Bcl-2 adalah protoonkogen keluarga Bcl yang berperan menghambat proses apoptosis sel dan bekerja menekan protein Bax (pro apoptosis. Berbagai upaya penatalaksanaan penyakit kanker masih banyak menemui kendala,sehingga peneliti menggali tanaman obat yaitu buah delima. Buah delima sebagai tanaman obat, mudah didapat dan harganya murah. Ellagic acid (EA senyawa tunggal bahan aktif dari ekstrak buah delima yang memiliki aktivitas sebagai anti kanker secara in-vitro tetapi EA aktivitas dan konsentrasinya dalam plasma rendah, kelarutan dalam air rendah, metabolisme (EA tidak larut dalam intestinal. Fakta ini mendorong peneliti untuk membandingkan dengan whole ekstrak delima (PGL yang terdiri dari beberapa senyawa bahan aktif, tidak hanya ellagic acid, memungkinkan beberapa senyawa bahan aktif pada PGL bisa bekerja sinergis, sehingga efeknya lebih poten. tujuan: Tujuan penelitian ini membandingkan antara EA, dengan whole ekstrak buah delima (PGL dalam menurunkan ekspresi Bcl-2. Metode: Metode penelitian yang digunakan adalah eksperimental laboratories, 32 ekor mencit (Balb/c, jantan, umur 5 bulan dibagi secara random menjadi 4 kelompok, 2 kelompok kontrol (K0: tidak dipapar benzopirene dan tidak diberi perlakuan, K1: dipapar benzopirene dan tidak diberi perlakuan, 2 kelompok perlakuan (P1: dipapar benzopirene dan diberi EA, P2: dipapar benzopirene dan diberi PGL. Pemeriksaan dengan menggunakan teknik imunohistokimia. hasil: Hasil penelitian menunjukkan bahwa pemberian PGL dapat menurunkan ekspresi Bcl-2 lebih tinggi dibandingkan EA pada sel epitel ganas mukosa rongga mulut mencit. Kesimpulan: Kesimpulan penelitian ini adalah pemberian PGL dapat membunuh sel ganas pada rongga mulut mencit dengan jalan meningkatkan apoptosis melalui penurunan ekspresi Bcl-2 lebih tinggi dibandingkan pemberian EA.

  16. Optimisation of Microwave-Assisted Extraction of Pomegranate (Punica granatum L.) Seed Oil and Evaluation 
of Its Physicochemical and Bioactive Properties.

    Science.gov (United States)

    Çavdar, Hasene Keskin; Yanık, Derya Koçak; Gök, Uğur; Göğüş, Fahrettin

    2017-03-01

    Pomegranate seed oil was extracted in a closed-vessel high-pressure microwave system. The characteristics of the obtained oil, such as fatty acid composition, free fatty acidity, total phenolic content, antioxidant activity and colour, were compared to those of the oil obtained by cold solvent extraction. Response surface methodology was applied to optimise extraction conditions: power (176-300 W), time (5-20 min), particle size (d=0.125-0.800 mm) and solvent to sample ratio (2:1, 6:1 and 10:1, by mass). The predicted highest extraction yield (35.19%) was obtained using microwave power of 220 W, particle size in the range of d=0.125-0.450 mm and solvent-to-sample ratio of 10:1 (by mass) in 5 min extraction time. Microwave-assisted solvent extraction (MASE) resulted in higher extraction yield than that of Soxhlet (34.70% in 8 h) or cold (17.50% in 8 h) extraction. The dominant fatty acid of pomegranate seed oil was punicic acid (86%) irrespective of the extraction method. Oil obtained by MASE had better physicochemical properties, total phenolic content and antioxidant activity than the oil obtained by cold solvent extraction.

  17. Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract

    OpenAIRE

    Bogdan C; Iurian S; Tomuta I; Moldovan M.

    2017-01-01

    Cătălina Bogdan,1 Sonia Iurian,2 Ioan Tomuta,2 Mirela Moldovan1 1Department of Dermatopharmacy and Cosmetics, 2Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania Abstract: Striae distensae are a frequent skin condition associated with pregnancy, weight change or lack of skin elasticity. The aim of this research was to obtain a topical product containing herbal active ingredients with documen...

  18. Optimisation of Microwave-Assisted Extraction of Pomegranate (Punica granatum L. Seed Oil and Evaluation of Its Physicochemical and Bioactive Properties

    Directory of Open Access Journals (Sweden)

    Hasene Keskin Çavdar

    2017-01-01

    Full Text Available Pomegranate seed oil was extracted in a closed-vessel high-pressure microwave system. The characteristics of the obtained oil, such as fatty acid composition, free fatty acidity, total phenolic content, antioxidant activity and colour, were compared to those of the oil obtained by cold solvent extraction. Response surface methodology was applied to optimise extraction conditions: power (176–300 W, time (5–20 min, particle size (d=0.125–0.800 mm and solvent to sample ratio (2:1, 6:1 and 10:1, by mass. The predicted highest extraction yield (35.19 % was obtained using microwave power of 220 W, particle size in the range of d=0.125–0.450 mm and solvent-to-sample ratio of 10:1 (by mass in 5 min extraction time. Microwave-assisted solvent extraction (MASE resulted in higher extraction yield than that of Soxhlet (34.70 % in 8 h or cold (17.50 % in 8 h extraction. The dominant fatty acid of pomegranate seed oil was punicic acid (86 % irrespective of the extraction method. Oil obtained by MASE had bett er physicochemical properties, total phenolic content and antioxidant activity than the oil obtained by cold solvent extraction.

  19. Protection against oxidative damage in human erythrocytes and preliminary photosafety assessment of Punica granatum seed oil nanoemulsions entrapping polyphenol-rich ethyl acetate fraction

    OpenAIRE

    Baccarin,Thaisa; Mitjans, Montserrat; Lemos-Senna,Elenara; Vinardell, Maria Pilar

    2015-01-01

    The main purpose of the present study is to evaluate the ability of nanoemulsion entrapping pomegranate peel polyphenol-rich ethyl acetate fraction (EAF) prepared from pomegranate seed oil and medium chain triglyceride to protect human erythrocyte membrane from oxidative damage and to assess preliminary in vitro photosafety. In order to evaluate the phototoxic effect of nanoemulsions, human red blood cells (RBCs) are used as a biological model and the rate of haemolysis and photohaemolysis (5...

  20. Antimicrobial Efficacy of Punica granatum mesocarp, Nelumbo nucifera Leaf, Psidium guajava Leaf and Coffea Canephora Extract on Common Oral Pathogens: An In-vitro Study.

    Science.gov (United States)

    Mehta, Viral V; Rajesh, Gururaghavendran; Rao, Ashwini; Shenoy, Ramya; B H, Mithun Pai

    2014-07-01

    Alternative therapies are increasingly being explored as extensive use of synthetic chemicals has led to the emergence of substantial side effects. Phytomedicine has been well practiced as traditional medicine in various cultures for treatment of oral diseases. It has gained importance of late as an alternative to the conventional therapy. Various plant and fruit extracts have been monitored recently to assess their potential against the common oral pathogens. Aim of this study was to assess in-vitro efficacy of pomegranate peel, lotus leaf, guava leaf and coffee extracts on oral microorganisms. Concentrations of 1%, 5%, 10%, 15% and 20% were prepared for each, followed by efficacy testing using disc diffusion method against Streptococcus mutans, Streptococcus mitis, Porphyromonas gingivalis, Prevotella intermedia and Candida albicans. All the four extracts were found to be effective against S.mutans and S.mitis, with maximum efficacy against S.mutans and S.mitis displayed by pomegranate and lotus. Antifungal efficacy was demonstrated by coffee and pomegranate. Guava, lotus and coffee were effective against P.intermedia, while only coffee was found to be effective against P. gingivalis. All the results were found to be statistically significant (p coffee displayed significant anticariogenic effect while coffee was found to be most effective against periodontal pathogens as well as Candida albicans. RESULTS revealed that natural products may be used as economical and suitable adjuvant to synthetic medicines and compounds and their judicious use might not only help to inhibit the side effects of synthetic chemicals but also prove to be cost effective in developing economies.

  1. Anti-inflammatory effects of pomegranate (Punica granatum L.) husk ellagitannins in Caco-2 cells, an in vitro model of human intestine.

    Science.gov (United States)

    Hollebeeck, Sylvie; Winand, Julie; Hérent, Marie-France; During, Alexandrine; Leclercq, Joëlle; Larondelle, Yvan; Schneider, Yves-Jacques

    2012-08-01

    This study aimed at evaluating the anti-inflammatory properties of a pomegranate fruit husk (PomH) polyphenolic extract, rich in punicalagin, using Caco-2 cells, an in vitro model of human intestinal epithelium. Differentiated cells in bicameral inserts were pretreated or not with a PomH extract or punicalagin, as reference, at the apical side, representing the intestinal lumen. Inflammation was then induced with a cocktail of cytokines (Il-1β, TNFα and IFNγ) and LPS. After 24 h incubation, 3 pro-inflammatory markers, i.e., interleukin (IL)-6, IL-8 and monocyte chemoattractant protein (MCP)-1, were assayed both at their gene transcription (qRT-PCR) and secretion (ELISA) levels. As previously described, the pro-inflammatory cocktail significantly stimulated these 3 markers, at the gene transcript and secretion levels. In inflamed cells, a significant down-regulation of the transcription of the genes encoding IL-6 and MCP-1 was observed in the presence of the PomH extract or punicalagin, while IL-8 transcription was unaffected. Both treatments also decreased the amounts of the 3 proteins with dose-response effects, but only in the apical compartment. A lowered ELISA response was also observed when either IL-6, IL-8 or MCP-1 were mixed with punicalagin in a cell-free culture medium, indicating a direct molecular interaction. In conclusion, the punicalagin-rich PomH extract tested showed anti-inflammatory properties in the Caco-2 in vitro intestinal model. It acted both on the pro-inflammatory gene transcription and protein levels, the later phenomenon being possibly due to a direct molecular trapping. These data suggest that pomegranate husk could be an interesting natural source contributing to prevent intestinal chronic inflammation.

  2. Effect of dipping in pomegranate (Punica granatum) fruit juice phenolic solution on the shelf life of chicken meat under refrigerated storage (4°C).

    Science.gov (United States)

    Vaithiyanathan, S; Naveena, B M; Muthukumar, M; Girish, P S; Kondaiah, N

    2011-07-01

    An experiment was conducted to evaluate the effect of dipping in pomegranate fruit juice phenolics (PFJP) solution on the shelf life of chicken meat held under refrigerated storage at 4°C. Breast muscle obtained from spent hens was dipped (1:2w/v; muscle: liquid) in sterile water or in sterile water with 0.02% (v/v) PFJP, packed, stored at 4°C for 28 days and samples were analyzed on 2 days of intervals. Thiobarbituric acid reactive substance values were lower in samples treated with PFJP. Total sulfhydryl and protein bound sulfhydryl content values were higher in samples treated with PFJP. Microbial quality evaluation showed that aerobic and psychrotrophic counts were higher in samples treated without PFJP. Sensory evaluation revealed that acceptability level of samples treated without PFJP decreased on 12th day of storage. It is concluded that spent hen breast meat samples dipped in 0.02% PFJP reduced protein oxidation and inhibited microbial growth and sensorily acceptable up to 12 days of refrigerated storage at 4°C. Copyright © 2011 Elsevier Ltd. All rights reserved.

  3. The inhibition of malignant epithelial cells in mucosal injury in the oral cavity of strains by pomegranate fruit extract (Punica granatum linn) through Bcl-2 expression

    OpenAIRE

    Sri Hernawati

    2013-01-01

    Background: Squamous cell carcinoma of oral cavity is a malignant neoplasms derived from epithelia. The malignant neoplasms are cells that have changed their structure and function, and their number becomes increasing abnormally, invasive, and metastatic. Carcinoma can be caused by the resistance of malignant cell apoptosis. Bcl-2 is a proto-oncogene of Bcl family that inhibits the process of cell apoptosis and suppresses Bax protein (pro-apoptotic). The management efforts of cancer diseases,...

  4. Antimicrobial Activity of Aloevera barbedensis, Daucus carota, Emblica officinalis, Honey and Punica granatum and Formulation of a Health Drink and Salad

    Directory of Open Access Journals (Sweden)

    Jeswin Philip

    2012-09-01

    Full Text Available Aims: Indian folk medicine has been in practice from time immemorial. Traditional medicine interconnects our body with nature for a healthy living. The naturally occurring antimicrobials in food vary in their efficacy and function, toxicology, safety and mechanism of action against microorganisms.Methodology and Results: The study revitalizes the traditional system of medicine in order to achieve self reliance in health care and health for all by analyzing the antimicrobial property of aqueous extracts of aloevera (Aloevera barbedensis, carrot (Daucus carota, Indian gooseberry (Emblica officinalis, honey and pomegranate (Punicagranatum, and to assess the reason for inhibition of growth of pathogenic organisms by DNA and protein analysis. Various aqueous extracts showed inhibition to microrganisms like Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexineri and Staphylococcus aureus.Conclusion significance and impact of study: The study also formulated and standardized a nourishing health drink and salad using the tested foods and estimated their shelf life and nutritive value. The health drink and salad had a low protein, low fat and moderate carbohydrate content. Therapeutically this drink and salad can be used to treat obesity.

  5. Effect of Postharvest Application of Thyme Essential oil on Quality and Shelf-life of Pomegranate (Punica granatum cv. Tarom red skin Fruit

    Directory of Open Access Journals (Sweden)

    M. Ghfouri

    2016-07-01

    Full Text Available Introduction: Due to high quality, Iran pomegranate is quite competitive compared to other countries is unrivaled among agricultural products and has great economic importance. Using essential oil is a new idea to reduce postharvest losses and increase the horticultural crop storage life and control of fungal infection. In this context, a factorial experiment based on completely randomized design was conducted to study the postharvest spraying of thyme essential oil on storage life and qualitative characteristics of pomegranate fruit (cv. Tarom red skin Materials and Methods: Pomegranate fruit (cv. Tarom red skin was prepared and transferred to University of Zanjan, Horticulture postharvest physiology lab. Treatments were included essential oil of thyme at four levels (0, 500, 1000, 1500 mg/l and the cold time storage (6 °C and 85% of relative humidity at three levels (one, two and three months (by four replications. In the first experiment, 180 normal pomegranate fruits were treated with thyme essential oil. In the second experiment, fruits were infected with spores of the fungus Aspergillus niger and then treated with essential oil. During experiment, total soluble solids (TSS, titratable acidity (TA, TSS/TA ratio, pH, anthocyanin, electrolyte leakage, chilling injury, weight loss and fungal decay were evaluated. Fruit juice TSS was determined with a hand-refractometer at room temperature. TA was determined by titration an aliquot (20 mL of the juice with 0.1 N NaOH and the results were expressed as a percentage of citric acid. The maturity index (TSS/TA ratio was evaluated as the TSS/TA ratio. Fruit juice pH was measured using a pH meter. Anthocyanin was performed to method Fuleki & Francis. Electrolyte leakage was measured according to McCollum & McDonald method. Weight loss was measured according to Ershadi method. Chilling injury was measured by Wang method. Decay was visually evaluated and expressed as percentage. An analysis of variance was used to analyze difference between treatments and the Duncan test was applied for mean separation at p

  6. The Effect of Two Methods of Pomegranate (Punica granatum L Juice Extraction on Quality During Storage at 4∘C

    Directory of Open Access Journals (Sweden)

    Graça Miguel

    2004-01-01

    Full Text Available The effect of two extraction methods of pomegranate juice on its quality and stability was evaluated. The first method consisted of separation of the seeds from fruits and centrifugation. The second method consisted of squeezing fruit halves with an electric lemon squeezer. During a period of 72 hours of cold storage at 4∘C, the juices were evaluated for the presence of sugars, organic acids, and anthocyanins. Delphinidin 3-glucoside was identified to be the major anthocyanin present at the level of 45–69 mg/L. Among the organic acids, oxalic and tartaric acids dominated. The major sugars detected in pomegranate juice were glucose and sucrose. No significant differences in the content of sugars, organic acids, or anthocyanins in juices obtained through application of the two different extraction methods were detected, with the exception of the drastic decrease of cyanidin 3,5-diglucoside level in juice obtained by seed centrifugation. The pH did not show differences between treatments. Titrable acidity and the level of sugars expressed as ∘Brix decreased after 32 and 15 hours after extraction, respectively, when juice was obtained by centrifuging the seeds.

  7. Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli.

    Science.gov (United States)

    Pagliarulo, Caterina; De Vito, Valentina; Picariello, Gianluca; Colicchio, Roberta; Pastore, Gabiria; Salvatore, Paola; Volpe, Maria Grazia

    2016-01-01

    In the present study major polyphenols of pomegranate arils and peel by-products were extracted in 50% (v/v) aqueous ethanol, characterized and used in microbiological assays in order to test antimicrobial activity against clinically isolated human pathogenic microorganisms. Total concentration of polyphenols and in vitro antioxidant properties were determined by the Folin-Ciocalteu and DPPH methods, respectively. The most abundant bioactive molecules, including anthocyanins, catechins, tannins, gallic and ellagic acids were identified by RP-HPLC-DAD, also coupled to off-line matrix assisted laser desorption/ionization (MALDI-TOF) mass spectrometry (MS). The inhibitory spectrum of extracts against test microorganisms was assessed by the agar well-diffusion method. Data herein indicated that both pomegranate aril and peel extracts have an effective antimicrobial activity, as evidenced by the inhibitory effect on the bacterial growth of two important human pathogens, including Staphylococcus aureus and Escherichia coli, which are often involved in foodborne illness. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. A "White" Anthocyanin-less Pomegranate (Punica granatum L.) Caused by an Insertion in the Coding Region of the Leucoanthocyanidin Dioxygenase (LDOX; ANS) Gene.

    Science.gov (United States)

    Ben-Simhon, Zohar; Judeinstein, Sylvie; Trainin, Taly; Harel-Beja, Rotem; Bar-Ya'akov, Irit; Borochov-Neori, Hamutal; Holland, Doron

    2015-01-01

    Color is an important determinant of pomegranate fruit quality and commercial value. To understand the genetic factors controlling color in pomegranate, chemical, molecular and genetic characterization of a "white" pomegranate was performed. This unique accession is lacking the typical pomegranate color rendered by anthocyanins in all tissues of the plant, including flowers, fruit (skin and arils) and leaves. Steady-state gene-expression analysis indicated that none of the analyzed "white" pomegranate tissues are able to synthesize mRNA corresponding to the PgLDOX gene (leucoanthocyanidin dioxygenase, also called ANS, anthocyanidin synthase), which is one of the central structural genes in the anthocyanin-biosynthesis pathway. HPLC analysis revealed that none of the "white" pomegranate tissues accumulate anthocyanins, whereas other flavonoids, corresponding to biochemical reactions upstream of LDOX, were present. Molecular analysis of the "white" pomegranate revealed the presence of an insertion and an SNP within the coding region of PgLDOX. It was found that the SNP does not change amino acid sequence and is not fully linked with the "white" phenotype in all pomegranate accessions from the collection. On the other hand, genotyping of pomegranate accessions from the collection and segregating populations for the "white" phenotype demonstrated its complete linkage with the insertion, inherited as a recessive single-gene trait. Taken together, the results indicate that the insertion in PgLDOX is responsible for the "white" anthocyanin-less phenotype. These data provide the first direct molecular, genetic and chemical evidence for the effect of a natural modification in the LDOX gene on color accumulation in a fruit-bearing woody perennial deciduous tree. This modification can be further utilized to elucidate the physiological role of anthocyanins in protecting the tree organs from harmful environmental conditions, such as temperature and UV radiation.

  9. Effect of Modified Atmosphere Packaging on Aril Physico-chemical and Microbial Properties of Two Pomegranate Cultivars (Punica granatum L. Grown in Iran

    Directory of Open Access Journals (Sweden)

    Sedighe Tavasoli Talarposhti

    2016-10-01

    Full Text Available Background and Objectives: Edible parts of pomegranate fruits are a rich source of bioactive compounds. The present research examines the effect of modified atmosphere packaging on the fruit physico-chemical and microbial properties of two commercial pomegranate cultivars grown in Iran. Materials and Methods: The arils were packaged and stored under four different atmospheres. All of the packaged samples were stored at 4 °C for 15 days. Results: The results revealed an increase in total acidity of all treatments. The highest total soluble solid (TSS was observed in ‘Yousef-Khani’­ stored in 10% O2 + 15% CO2, while ‘Malas-e-Saveh’ treated with 20% O2 + 5% CO2 showed the highest degree of TSS. The mean value of a* in ‘Malas-e-Saveh’ arils packed with normal and (15% O2 + 10% CO2 + 75% N2 atmosphere increased significantly. The L* showed a decrease in ‘Yousef-Khani’­. Total phenolic compounds gradually increased during storage. After storage, decreases in total anthocyanin contents ranged from 12 to 30% for ‘Yousef-Khani’­. The overall antioxidant activity of arils in ‘Yousef-Khani’ showed a 6-15% increase during storage. However, a reverse effect was observed for ‘Malas-e-Saveh’. The lowest microbial counts were recorded under the atmosphere containing 10 and 15% CO2. Conclusions: Packaging of ‘Malas-e-Saveh’ arils in 15% O2 + 10% CO2 and ‘Yousef-Khani’ in 15% O2 + 10% CO2 or 10% O2 + 15% CO2 is recommended to extend the shelf-life of ready-to-eat arils. Keywords: Pomegranate, Modified atmosphere, Phenolic compounds, Anthocyanin, Antioxidant activity

  10. Characterization of bacterial knot disease caused by Pseudomonas savastanoi pv. savastanoi on pomegranate (Punica granatum L.) trees: a new host of the pathogen.

    Science.gov (United States)

    Bozkurt, I A; Soylu, S; Mirik, M; Ulubas Serce, C; Baysal, Ö

    2014-11-01

    This study aimed to isolate and identify the causal organism causing hyperplastic outgrowths (knots) on stems and branches of pomegranate trees in the Eastern Mediterranean region of Turkey. Bacterial colonies were isolated from young knots on plates containing selective nutrient media. Biochemical tests, fatty acid analysis and PCR were performed to identify possible causal disease agent. Representative isolates were identified as Pseudomonas.pv.savastanoi (Psv) using biochemical tests, fatty acid profiling and PCR. Following inoculation of pomegranate plants (cv. hicaz) with bacterial suspensions, 25 of 54 bacterial isolates caused typical knots at the site of inoculation. PCR analysis, using specific primer for Psv, generated a single amplicon from all isolates. The similarity of the sequence of Turkish pomegranate isolate was 99% similar to the corresponding gene sequences of Psv in the databases. Based on symptoms, biochemical, molecular, pathogenicity tests and sequence analyses, the disease agent of knots observed on the pomegranate trees is Psv. To the best of our knowledge, this research has revealed pomegranate as a natural host of Psv, which extends the list of host plant species affected by the pathogen in the world and Turkey. Pomegranate trees were affected by the disease with outgrowths (galls or knot) disease. Currently, there is no published study on disease agent(s) causing the galls or knots on pomegranate trees in worldwide. Bacterial colonies were isolated from young knots. The causal agent of the knot Pseudomonas savastanoi pv.savastanoi (Psv) was identified based on symptoms, biochemical, molecular methods, pathogenicity tests and sequence analysis. To the best of our knowledge, this is the first report of Psv on pomegranate as a natural host, which extends the growing list of plant species affected by this bacterium in the world and Turkey. © 2014 The Society for Applied Microbiology.

  11. Pomegranate (Punica granatum: a natural source for the development of therapeutic compositions of food supplements with anticancer activities based on electron acceptor molecular characteristics

    Directory of Open Access Journals (Sweden)

    Veljko Veljkovic

    2016-10-01

    Full Text Available Background: Numerous in vitro and in vivo studies, in addition to clinical data, demonstrate that pomegranate juice can prevent or slow-down the progression of some types of cancers. Despite the well-documented effect of pomegranate ingredients on neoplastic changes, the molecular mechanism(s underlying this phenomenon remains elusive. Methods: For the study of pomegranate ingredients the electron-ion interaction potential (EIIP and the average quasi valence number (AQVN were used. These molecular descriptors can be used to describe the long-range intermolecular interactions in biological systems and can identify substances with strong electron-acceptor properties. In this study, candidate human proteins interacting with pomegranate flavonoids have been analyzed by the informational spectrum method (ISM. This represents a virtual spectroscopy method for studying protein molecular interactions. Results: Our analysis indicates that the anti-cancer properties of pomegranate juice can be ascribed to the strong electron-acceptor properties of its chemical ingredients. This analysis also suggests that pomegranate flavonoids inhibit the “NF-kappaB” (NF-B pathway, which plays a critical role in the pathogenesis of cancer. Conclusion: The results offer a possible explanation for an important molecular mechanism underlying the anticancer activity of pomegranate ingredients, which could also serve as a basis for the development of new therapeutic compositions of food supplements with pomegranate-like anticancer properties.

  12. Respons Pertumbuhan Dan Komposisi Rantai Panjang Polyisoprenoid Semai Berjenis Sekresi Xylocarpus Granatum Koenig. Terhadap Salinitas

    OpenAIRE

    Siregar, Nurfalah; Basyuni, Mohammad; Utomo, Budi

    2015-01-01

    Growth response and composition of long chain polyisoprenoid of minor secretor Xylocarpus granatum Koenig seedlings to salinity was studied in the greenhouse, Faculty of Agriculture and Laboratory of Forest Ecology, University of Sumatera Utara. Research was started from July to November 2014. This study used five levels of salinity, namely 0%, 0,5%, 1,5%, 2% and 3% X. granatum where seedlings were grown for 3 months. The best result was obtained at 0,5% salinity, seedling height at 0,5% sa...

  13. Hairy AdS solitons

    Energy Technology Data Exchange (ETDEWEB)

    Anabalón, Andrés, E-mail: andres.anabalon@uai.cl [Departamento de Ciencias, Facultad de Artes Liberales and Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez, Av. Padre Hurtado 750, Viña del Mar (Chile); Astefanesei, Dumitru, E-mail: dumitru.astefanesei@pucv.cl [Instituto de Física, Pontificia Universidad Católica de Valparaíso, Casilla 4059, Valparaíso (Chile); Choque, David, E-mail: brst1010123@gmail.com [Instituto de Física, Pontificia Universidad Católica de Valparaíso, Casilla 4059, Valparaíso (Chile); Universidad Técnica Federico Santa María, Av. España 1680, Valparaíso (Chile)

    2016-11-10

    We construct exact hairy AdS soliton solutions in Einstein-dilaton gravity theory. We examine their thermodynamic properties and discuss the role of these solutions for the existence of first order phase transitions for hairy black holes. The negative energy density associated to hairy AdS solitons can be interpreted as the Casimir energy that is generated in the dual filed theory when the fermions are antiperiodic on the compact coordinate.

  14. Biological Data on Anovia punica Gordon (Coleoptera: Coccinellidae), a Predator of Crypticerya multicicatrices Kondo & Unruh (Hemiptera: Monophlebidae).

    Science.gov (United States)

    Pinchao, E C; Sotelo, P; González, G; Kondo, T

    2017-10-12

    The coccinellid beetle Anovia punica Gordon (Coleoptera: Coccinellidae: Noviini) is an important predator of the Colombian fluted scale, Crypticerya multicicatrices Kondo & Unruh (Hemiptera: Monophlebidae). In order to gather information on the biological traits of A. punica, we conducted a series of studies, including of the developmental time of each life history stage, estimation of life table parameters, and predation rates under laboratory conditions [25.1 ± 1.6°C, with 70.5 ± 7.3% RH, and natural light regime, approx. 12:12 (L:D) h]. Developmental stages of A. punica were categorized as follows: egg stage, four larval instars, prepupal instar, pupal instar, and adult. Developmental time from egg to adult emergence averaged 29.41 ± 1.85 days, and 47.6% of the eggs developed to adulthood. Female and male survival was 94.42 and 90 days, respectively. Life table parameters show that one female of A. punica is replaced by 86 females (R 0 ), the intrinsic growth rate (r m ) was 0.1115, the average generation time (T) was 40 days, and the doubling time (D t ) was 6.2 days. The life table parameters suggest that A. punica can be used as a potential predator of C. multicicatrices and, more importantly, provided baseline information for a mass-rearing protocol. This is the first detailed study on the biology of A. punica that reports the potential of this predator as a biological control agent for scale insects of the tribe Iceryini.

  15. Adding Ajax

    CERN Document Server

    Powers, Shelley

    2007-01-01

    Ajax can bring many advantages to an existing web application without forcing you to redo the whole thing. This book explains how you can add Ajax to enhance, rather than replace, the way your application works. For instance, if you have a traditional web application based on submitting a form to update a table, you can enhance it by adding the capability to update the table with changes to the form fields, without actually having to submit the form. That's just one example.Adding Ajax is for those of you more interested in extending existing applications than in creating Rich Internet Applica

  16. Archeologia e archeometria a Monte Sirai: diffrattometrie ai raggi X sui resti scheletrici della necropoli fenicia e punica (campagna di scavi 2007)

    OpenAIRE

    Guirguis, Michele

    2008-01-01

    Nel seguente contributo si discuteranno i risultati delle analisi archeometriche effettuate su alcuni reperti osteologici selezionati tra i recenti contesti provenienti dalla necropoli fenicia e punica di Monte Sirai.

  17. studies on in vitro evaluation of antidiabetic potentials of ...

    African Journals Online (AJOL)

    userpc

    Hence the current work focuses on investigating the anti-diabetic activity of fruit peel of Citrullus lanatus (watermelon) and Punica granatum. (pomegranate) using the above mentioned assays. Our results suggested that methanol extract of Citrullus lanatus and Punica granatum peels showed potential anti-diabetic activity.

  18. Research Paper ISSN 0189-6016©2008

    African Journals Online (AJOL)

    AJTCAM

    the effect of ethanolic extract of Punica granatum seeds on cognitive performance of aged and scopolamine treated young mice using one trial step-down type ... Chronic administration (21 days) of Punica granatum extract and vitamin C significantly (p < 0.05) reversed the age induced or scopolamine induced retention ...

  19. KANDUNGAN BUAH-BUAHAN DALAM ALQUR’AN: BUAH TIN (Ficus carica L, ZAITUN (Olea europea L, DELIMA (Punica granatum L, ANGGUR (Vitis vinivera L, DAN KURMA (Phoenix dactylifera L UNTUK KESEHATAN

    Directory of Open Access Journals (Sweden)

    nur khasanah

    2016-03-01

    Full Text Available Aneka ragam buah-buahan segar diciptakan Sang Khalik untuk umat manusia. Di antara sekian banyak buah-buahan itu, salah satu yang disebutkan Allah SWT dalam Alquran. Adalah buah tin, zaitun, delima, anggur, dan kurma. Untuk itulah kita sebagai muslim perlu men- getahui zat-zat  yang terkandung dalam buah tersebut, se- hingga dapat memanfaatkan buah tersebut dengan sebaik- baiknya. Tidak ada sekecil apa pun Allah ciptaan jika tidak membawa kemanfaatan bagi manusia.

  20. Potential of pomegranate fruit extract (Punica granatum Linn. to increase vascular endothelial growth factor and platelet-derived growth factor expressions on the post-tooth extraction wound of Cavia cobaya

    Directory of Open Access Journals (Sweden)

    Intan Nirwana

    2017-08-01

    Full Text Available Background: Pomegranates fruit extracts have several activities, among others, anti-inflammatory, antibacterial, and antioxidants that have the main content punicalagin and ellagic acid. Pomegranate has the ability of various therapies through different mechanisms. Vascular endothelial growth factor (VEGF function was to form new blood vessels produced by various cells one of them was macrophages. Platelet-derived growth factor (PDGF was a growth factor proven chemotactic, increased fibroblast proliferation and collagen matrix production. In addition, VEGF and PDGF synergize in their ability to vascularize tissues. The PDGF function was to stabilize and regulate maturation of new blood vessels. Activities of pomegranate fruit extract were observed by measuring the increased of VEGF and PDGF expression as a marker of wound healing process. Aim: To investigate the potential of pomegranate extracts on the tooth extraction wound to increase the expression of VEGF and PDGF on the 4th day of wound healing process. Materials and Methods: This study used 12 Cavia cobaya, which were divided into two groups, namely, the provision of 3% sodium carboxymethyl cellulose and pomegranate extract. The 12 C. cobaya would be executed on the 4th day, the lower jaw of experimental animals was taken, decalcified about 30 days. The expression of VEGF and PDGF was examined using immunohistochemical techniques. The differences of VEGF and PDGF expression were evaluated statistically using t-test. Results: Statistically analysis showed that there were significant differences between control and treatment groups (p<0.05. Conclusion: Pomegranate fruit extract administration increased VEGF and PDGF expression on post-tooth extraction wound.

  1. Benefits of pomegranate (Punica granatum Linn) fruit extracts to weight changes, total protein, and uric acid in white rats (Rattus norvegicus) as an animal model of acute renal failure.

    Science.gov (United States)

    Primarizky, Hardany; Yuniarti, Wiwik Misaco; Lukiswanto, Bambang Sektiari

    2016-11-01

    The occurrence of acute renal failure (ARF) cases continues to increase every year. Some of the cases are due to nephrotoxic effect caused by overdose of antibiotic consumption or abuse of the drug, gentamicin. An antibiotic therapy that can be used to overcome in such a case is the pomegranate extracts. However, until now, studies using pomegranate for cases of ARF have not been done. This study aims to determine changes in body weight, the levels of total protein (TP), and the levels of serum uric acid (UA) as a result of the pomegranate extract consumption. A total number of 32 rats (Rattus norvegicus) were divided into four groups randomly. One group was assigned as the control group (P0) and given intraperitoneal (i.p.) saline and 0.3% carboxy methyl cellulose sodium (CMC) Na; P1 was provided with 80 mg/kg bw/i.p. gentamicin and 0.3% CMC Na orally, P2 was supplied with 80 mg/kg bw/i.p. gentamicin and ellagic acid in 0.3% CMC Na, and P3 was given 80 mg/kg bw/i.p. gentamicin and 150 mg/kg bw pomegranate extract in 0.3% CMC Na. The provision of treatment was carried out in 8 days and followed by making the overthrow of body weight and blood sampling for the examination of study variables. The results taken by doing the analysis of variance method for the four treatment groups show that the control group (P0) has significant differences from P1, P2, and P3 (p<0.05), but there are no significant differences among the other three treatment groups. Meanwhile, the average values of serum UA levels among P1, P2, and P3 indicate significant differences. In conclusion, the administration of pomegranate extracts in the treatment of nephrotoxicity toward rats is effective to maintain normal body weight, normal TP levels, and the UA blood serum of the rats. As this study is a preventive therapy, it needs further researches about the effective dose as a curative therapy, its level of effectiveness and its long-term side effects.

  2. Analysis of phenolic compounds in different parts of pomegranate (Punica granatum) fruit by HPLC-PDA-ESI/MS and evaluation of their antioxidant activity: application to different Italian varieties.

    Science.gov (United States)

    Russo, Marina; Fanali, Chiara; Tripodo, Giusy; Dugo, Paola; Muleo, Rosario; Dugo, Laura; De Gara, Laura; Mondello, Luigi

    2018-01-19

    The analysis of pomegranate phenolic compounds belonging to different classes in different fruit parts was performed by high-performance liquid chromatography coupled with photodiode array and mass spectrometry detection. Two different separation methods were optimized for the analysis of anthocyanins and hydrolyzable tannins along with phenolic acids and flavonoids. Two C18 columns, core-shell and fully porous particle stationary phases, were used. The parameters for separation of phenolic compounds were optimized considering chromatographic resolution and analysis time. Thirty-five phenolic compounds were found, and 28 of them were tentatively identified as belonging to four different phenolic compound classes; namely, anthocyanins, phenolic acids, hydrolyzable tannins, and flavonoids. Quantitative analysis was performed with a mixture of nine phenolic compounds belonging to phenolic compound classes representative of pomegranate. The method was then fully validated in terms of retention time precision, expressed as the relative standard deviation, limit of detection, limit of quantification, and linearity range. Phenolic compounds were analyzed directly in pomegranate juice, and after solvent extraction with a mixture of water and methanol with a small percentage of acid in peel and pulp samples. The accuracy of the extraction method was also assessed, and satisfactory values were obtained. Finally, the method was used to study identified analytes in pomegranate juice, peel, and pulp of six different Italian varieties and one international variety. Differences in phenolic compound profiles among the different pomegranate parts were observed. Pomegranate peel samples showed a high concentration of phenolic compounds, ellagitannins being the most abundant ones, with respect to pulp and juice samples for each variety. With the same samples, total phenols and antioxidant activity were evaluated through colorimetric assays, and the results were correlated among them.

  3. Pengaruh Salinitas Terhadap Pertumbuhan Dan Komposisi Rantai Panjang Polyisoprenoid Semai Mangrove Sejati Minor Berjenis Sekresi Xylocarpus granatum Koenig

    OpenAIRE

    Siregar, Nurfalah

    2015-01-01

    Effect of salinity on the growth and composition of long chain polyisoprenoid in true mangrove of minor secretor Xylocarpus granatum Koenig seedlings. Studied in the greenhouse, Faculty of Agriculture and laboratory of forest ecology, University of Sumatera Utara. Research started from July to November 2014. This study used five levels of salinity, namely 0%; 0.5%; 1.5%; 2% and 3% where seedlings were grown for 3 months. The best result was obtained 0.5% salinity, seedling height at 0.5% sali...

  4. Estructura genética de poblaciones de Oligonychus perseae y Oligonychus punicae (Acari: Tetranychidae) en huertos de aguacate.

    OpenAIRE

    Guzmán Valencia, Stephanie

    2013-01-01

    La identidad y estructura genética de poblaciones de Oligonychus punicae y O. perseae (Acari: Tetranychidae) fue estudiada en siete localidades productoras de aguacate Persea americana var. Hass. La identidad de los ácaros fue determinada morfológica y molecularmente mediante la secuenciación de una fracción del gen Citocromo Oxidasa subunidad I (COI). La variación genética intraespecífica de diferentes poblaciones de ambas especies de ácaros fue estudiada mediante la secuenciación de las reg...

  5. Axion wormholes in AdS compactifications

    Science.gov (United States)

    Hertog, Thomas; Trigiante, Mario; Van Riet, Thomas

    2017-06-01

    We find regular axionic Euclidean wormhole solutions in Type IIB string theory compactified on {AdS}_5× {S}^5/{Z}_k . AdS/CFT enables a precise derivation of the axion content of the Euclidean theory, placing the string theory embedding of the wormholes on firm footing. This further sharpens the paradox posed by these solutions.

  6. Polarised Black Holes in AdS

    CERN Document Server

    Costa, Miguel S.; Oliveira, Miguel; Penedones, João; Santos, Jorge E.

    2016-05-03

    We consider solutions in Einstein-Maxwell theory with a negative cosmological constant that asymptote to global $AdS_{4}$ with conformal boundary $S^{2}\\times\\mathbb{R}_{t}$. At the sphere at infinity we turn on a space-dependent electrostatic potential, which does not destroy the asymptotic $AdS$ behaviour. For simplicity we focus on the case of a dipolar electrostatic potential. We find two new geometries: (i) an $AdS$ soliton that includes the full backreaction of the electric field on the $AdS$ geometry; (ii) a polarised neutral black hole that is deformed by the electric field, accumulating opposite charges in each hemisphere. For both geometries we study boundary data such as the charge density and the stress tensor. For the black hole we also study the horizon charge density and area, and further verify a Smarr formula. Then we consider this system at finite temperature and compute the Gibbs free energy for both $AdS$ soliton and black hole phases. The corresponding phase diagram generalizes the Hawkin...

  7. Current status of AdS instability

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    arXiv:1403.6471 and thoroughly developed in arXiv:1407.6273. On the other hand the negative cosmological constant allows for the existence of stable, time-periodic, asymptotically AdS solutions of Einstein equations [arXiv:1303.3186].

  8. AdS braneworld with Backreaction

    CERN Document Server

    Bilic, Neven

    2014-01-01

    We review the tachyon model derived from the dynamics of a 3-brane moving in the AdS5 bulk. The bulk geometry is based on the Randall-Sundrum II model extended to include the radion. The effective tachyon Lagrangian is modified due to the back-reaction of the brane on the bulk geometry.

  9. Lorentzian AdS, Wormholes and Holography

    CERN Document Server

    Arias, Raul E; Silva, Guillermo A

    2011-01-01

    We investigate the structure of two point functions for the QFT dual to an asymptotically Lorentzian AdS-wormhole. The bulk geometry is a solution of 5-dimensional second order Einstein Gauss Bonnet gravity and causally connects two asymptotically AdS space times. We revisit the GKPW prescription for computing two-point correlation functions for dual QFT operators O in Lorentzian signature and we propose to express the bulk fields in terms of the independent boundary values phi_0^\\pm at each of the two asymptotic AdS regions, along the way we exhibit how the ambiguity of normalizable modes in the bulk, related to initial and final states, show up in the computations. The independent boundary values are interpreted as sources for dual operators O^\\pm and we argue that, apart from the possibility of entanglement, there exists a coupling between the degrees of freedom leaving at each boundary. The AdS_(1+1) geometry is also discussed in view of its similar boundary structure. Based on the analysis, we propose a ...

  10. Baby Skyrmions in AdS

    Energy Technology Data Exchange (ETDEWEB)

    Elliot-Ripley, Matthew; Winyard, Thomas [Department of Mathematical Sciences, Durham University,South Rd, Durham (United Kingdom)

    2015-09-01

    We study the baby Skyrme model in a pure AdS background without a mass term. The tail decays and scalings of massless radial solutions are demonstrated to take a similar form to those of the massive flat space model, with the AdS curvature playing a similar role to the flat space pion mass. We also numerically find minimal energy solutions for a range of higher topological charges and find that they form concentric ring-like solutions. Popcorn transitions (named in analogy with studies of toy models of holographic QCD) from an n layer to an n+1-layer configuration are observed at topological charges 9 and 27 and further popcorn transitions for higher charges are predicted. Finally, a point-particle approximation for the model is derived and used to successfully predict the ring structures and popcorn transitions for higher charge solitons.

  11. AdS solutions through transgression

    Energy Technology Data Exchange (ETDEWEB)

    Donos, A. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Theory Group; Gauntlett, J.P. [Imperial College, London (United Kingdom). Blackett Lab.]|[Imperial College, London (United Kingdom). The Institute for Mathematical Sciences; Kim, Nakwoo [Kyung Hee Univ., Seoul (Korea). Dept. of Physics and Research Inst. of Basic Science

    2008-07-15

    We present new classes of explicit supersymmetric AdS{sub 3} solutions of type IIB supergravity with non-vanishing five-form flux and AdS{sub 2} solutions of D=11 supergravity with electric four-form flux. The former are dual to two-dimensional SCFTs with (0,2) supersymmetry and the latter to supersymmetric quantum mechanics with two supercharges. We also investigate more general classes of AdS{sub 3} solutions of type IIB supergravity and AdS{sub 2} solutions of D=11 supergravity which in addition have non-vanishing three-form flux and magnetic four-form flux, respectively. The construction of these more general solutions makes essential use of the Chern-Simons or ''transgression'' terms in the Bianchi identity or the equation of motion of the field strengths in the supergravity theories. We construct infinite new classes of explicit examples and for some of the type IIB solutions determine the central charge of the dual SCFTs. The type IIB solutions with non-vanishing three-form flux that we construct include a two-torus, and after two T-dualities and an S-duality, we obtain new AdS3 solutions with only the NS fields being non-trivial. (orig.)

  12. Predicting AD conversion

    DEFF Research Database (Denmark)

    Liu, Yawu; Mattila, Jussi; Ruiz, Miguel �ngel Mu�oz

    2013-01-01

    To compare the accuracies of predicting AD conversion by using a decision support system (PredictAD tool) and current research criteria of prodromal AD as identified by combinations of episodic memory impairment of hippocampal type and visual assessment of medial temporal lobe atrophy (MTA) on MRI...

  13. Antimicrobial and free radical scavenging activities of five ...

    African Journals Online (AJOL)

    Extracts from five indigenous Palestinian medicinal plants including Rosmarinus officinalis, Pisidium guajava, Punica granatum peel, grape seeds and Teucrium polium were investigated for antimicrobial and free radical scavenging activities against eight microorganisms, using well diffusion method. The microorganisms ...

  14. Adding more value to added-value

    DEFF Research Database (Denmark)

    Marian, Livia

    Recent studies reveal that consumers respond favourably to “organic plus” products with additional ethical attributes. The aim of the current study is to explore whether consumers would notice and value further improvements in the animal welfare standards than those imposed by the organic...... it is probably valued less than expected. The added attributes need to be thoroughly considered when developing and marketing “organic plus” products, as their effect on other product characteristics (e.g. high prices) can detract from their added value....

  15. Effect of punicalagin on proliferation of porcine ovarian granulosa cells in vitro

    OpenAIRE

    Dagmara Packová; Adriana Kolesárová

    2016-01-01

    Punicalagin is a major component responsible for pomegranate's (Punica granatum) antioxidant properties. Punicalagin is the predominant ellagitannin of Punica granatum and present in two isomeric forms: punicalagin α and β. Punicalagin is metabolised to ellagic acid (antioxidant) and microorganisms present in colon can metabolize ellagic acid to urolithins. The aim of in vitro study was to examine the effect of punicalagin on mitochondrial activity and markers of proliferation in porcine ovar...

  16. The political attack ad

    Directory of Open Access Journals (Sweden)

    Palma Peña-Jiménez, Ph.D.

    2011-01-01

    Full Text Available During election campaigns the political spot has a clear objective: to win votes. This message is communicated to the electorate through television and Internet, and usually presents a negative approach, which includes a direct critical message against the opponent, rather than an exposition of proposals. This article is focused on the analysis of the campaign attack video ad purposely created to encourage the disapproval of the political opponent among voters. These ads focus on discrediting the opponent, many times, through the transmission of ad hominem messages, instead of disseminating the potential of the political party and the virtues and manifesto of its candidate. The article reviews the development of the attack ad since its first appearance, which in Spain dates back to 1996, when the famous Doberman ad was broadcast, and examines the most memorable campaign attack ads.

  17. Twistor methods for AdS$_5$

    CERN Document Server

    Adamo, Tim; Williams, Jack

    2016-01-01

    We consider the application of twistor theory to five-dimensional anti-de Sitter space. The twistor space of AdS$_5$ is the same as the ambitwistor space of the four-dimensional conformal boundary; the geometry of this correspondence is reviewed for both the bulk and boundary. A Penrose transform allows us to describe free bulk fields, with or without mass, in terms of data on twistor space. Explicit representatives for the bulk-to-boundary propagators of scalars and spinors are constructed, along with twistor action functionals for the free theories. Evaluating these twistor actions on bulk-to-boundary propagators is shown to produce the correct two-point functions.

  18. Skil problemerne ad

    DEFF Research Database (Denmark)

    Kaspersen, Peter

    2007-01-01

    På grundlag af evalueringer og forskning i gymnasiereformen 2005 foreslås det at skille problemerne ad i forskellige niveauer. Herved kan der arbejdes med niveaudelte løsninger.......På grundlag af evalueringer og forskning i gymnasiereformen 2005 foreslås det at skille problemerne ad i forskellige niveauer. Herved kan der arbejdes med niveaudelte løsninger....

  19. Probing crunching AdS cosmologies

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, S. Prem; Vaganov, Vladislav [Department of Physics, Swansea University,Singleton Park, Swansea SA2 8PP (United Kingdom)

    2016-02-03

    Holographic gravity duals of deformations of CFTs formulated on de Sitter spacetime contain FRW geometries behind a horizon, with cosmological big crunch singularities. Using a specific analytically tractable solution within a particular single scalar truncation of N=8 supergravity on AdS{sub 4}, we first probe such crunching cosmologies with spacelike radial geodesics that compute spatially antipodal correlators of large dimension boundary operators. At late times, the geodesics lie on the FRW slice of maximal expansion behind the horizon. The late time two-point functions factorise, and when transformed to the Einstein static universe, they exhibit a temporal non-analyticity determined by the maximal value of the scale factor ã{sub max}. Radial geodesics connecting antipodal points necessarily have de Sitter energy E≲ã{sub max}, while geodesics with E>ã{sub max} terminate at the crunch, the two categories of geodesics being separated by the maximal expansion slice. The spacelike crunch singularity is curved “outward” in the Penrose diagram for the deformed AdS backgrounds, and thus geodesic limits of the antipodal correlators do not directly probe the crunch. Beyond the geodesic limit, we point out that the scalar wave equation, analytically continued into the FRW patch, has a potential which is singular at the crunch along with complex WKB turning points in the vicinity of the FRW crunch. We then argue that the frequency space Green’s function has a branch point determined by ã{sub max} which corresponds to the lowest quasinormal frequency.

  20. Studies on cytotoxic and clot lysis activity of probiotically fermented cocktail juice prepared using Camellia sinensis and Punica grantum

    Science.gov (United States)

    Biswas, Ananya; Deori, Meenakshi; Nivetha, A.; Mohansrinivasan, V.

    2017-11-01

    In the current research the effect of probiotic microorganisms viz; Lactococcus lactis and Lactobacillus plantarum on fermentation of Camellia sinensis and Punica grantum was studied. In vitro test were done to analyze the anticancer, antioxidant and atherosclerosis (clot lysis) properties of fermented juice. The juice was fermented for 48 and 96h, during which concentration of phenolic content, total acid content and free radical scavenging activity of the sample was analyzed by DPPH assay (α, α-diphenyl-β-picrylhydrazyl). Dropping of pH was observed after 48 h of fermentation. The clot lysis activity was found to be 80 % in 100μl concentration of fermented cocktail juice. The 96 h fermented sample has shown around 70% inhibition against colon cancer cell lines. Analytical study of HPLC proves the organic acid production such as ascorbic acid in superior amount for 96h of fermented sample, Based on the retention time, the corresponding peaks were detected at 4.919 and 4.831 min.

  1. Mobile ad hoc networking

    CERN Document Server

    John Wiley & Sons

    2004-01-01

    "Assimilating the most up-to-date information on research and development activities in this rapidly growing area, Mobile Ad Hoc Networking covers physical, data link, network, and transport layers, as well as application, security, simulation, and power management issues in sensor, local area, personal, and mobile ad hoc networks. Each of the book's sixteen chapters has been written by a top expert and discusses in-depth the most important topics in the field. Mobile Ad Hoc Networking is an excellent reference and guide for professionals seeking an in-depth examination of topics that also provides a comprehensive overview of the current state-of-the-art."--Jacket.

  2. In vivo analgesic activity and safety assessment of Vitis vinifera L ...

    African Journals Online (AJOL)

    grape) and Punica granatum (pomegranate) in Albino mal mice. Methods: The analgesic activity of fruit extracts of V. vinifera and P. granatum were examined in vivo using thermal stimulus assays (i.e., tail immersion and hot plate) and acetic ...

  3. Antiproton-Decelerator (AD)

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    When the Low-Energy Antiproton Ring (LEAR) was stopped in 1996, because of its costly operation, a cheaper way of continuing low-energy antiproton physics was sought. The Antiproton-Collector (AC), added in 1987 to the Antiproton Accumulator (AA) to provide a tenfold intensity increase, was converted into the Antiproton-Decelerator (AD). Antiprotons from the target at 3.5 GeV/c are decelerated to 100 MeV/c, and fast-ejected to the experiments. Major changes were necessary. Above all, the conversion from a constant-field machine to one with a magnetic cycle, modulating the field by an impressive factor 35. New systems for stochastic and electron cooling had to be added. Beam diagnostics at an intensity of only 2E7 antiprotons was a challenge. In 2000, the AD began delivery of antiprotons to the experiments.

  4. Ancient seed for modern cure – pomegranate review of therapeutic applications in periodontics

    Directory of Open Access Journals (Sweden)

    Arthiie Thangavelu

    2017-01-01

    Full Text Available Punica granatum (pomegranate, the member of Punicaceae family, is used in the prevention and treatment of health disorders. P. granatum contains diverse range of phytochemicals including ellagic acid, punicalagin, pedunculagin, quercetin, rutin, tannic acid, polyphenol, anthocyanins, and catechins. This review aims at providing an overview of the chemical constituents, antibacterial, anti-inflammatory, and antioxidant properties of P. granatum, and its role in the prevention and treatment of gingival and periodontal diseases.

  5. Ancient Seed for Modern Cure – Pomegranate Review of Therapeutic Applications in Periodontics

    Science.gov (United States)

    Thangavelu, Arthiie; Elavarasu, Sugumari; Sundaram, Rajasekar; Kumar, Tamilselvan; Rajendran, Dhivya; Prem, Fairlin

    2017-01-01

    Punica granatum (pomegranate), the member of Punicaceae family, is used in the prevention and treatment of health disorders. P. granatum contains diverse range of phytochemicals including ellagic acid, punicalagin, pedunculagin, quercetin, rutin, tannic acid, polyphenol, anthocyanins, and catechins. This review aims at providing an overview of the chemical constituents, antibacterial, anti-inflammatory, and antioxidant properties of P. granatum, and its role in the prevention and treatment of gingival and periodontal diseases. PMID:29284927

  6. Dynamic ad hoc networks

    CERN Document Server

    Rashvand, Habib

    2013-01-01

    Motivated by the exciting new application paradigm of using amalgamated technologies of the Internet and wireless, the next generation communication networks (also called 'ubiquitous', 'complex' and 'unstructured' networking) are changing the way we develop and apply our future systems and services at home and on local, national and global scales. Whatever the interconnection - a WiMAX enabled networked mobile vehicle, MEMS or nanotechnology enabled distributed sensor systems, Vehicular Ad hoc Networking (VANET) or Mobile Ad hoc Networking (MANET) - all can be classified under new networking s

  7. Adding and Deleting Images

    Science.gov (United States)

    Images are added via the Drupal WebCMS Editor. Once an image is uploaded onto a page, it is available via the Library and your files. You can edit the metadata, delete the image permanently, and/or replace images on the Files tab.

  8. What Value "Value Added"?

    Science.gov (United States)

    Richards, Andrew

    2015-01-01

    Two quantitative measures of school performance are currently used, the average points score (APS) at Key Stage 2 and value-added (VA), which measures the rate of academic improvement between Key Stage 1 and 2. These figures are used by parents and the Office for Standards in Education to make judgements and comparisons. However, simple…

  9. Adding an extra storey

    DEFF Research Database (Denmark)

    Engelmark, Jesper; Dahl, Torben; Melgaard, Ebbe

    2007-01-01

    of them had to be renovated after a shorter period. In stead of just replacing the original roof with a new one, it is now a days rather common to ad an extra storey where that is possible according to local planning. The reason is as a rule based on economical benefits, but very often this extra storey...

  10. Ads in Indonesia

    Directory of Open Access Journals (Sweden)

    Wulan Roro Retno

    2017-01-01

    Full Text Available Cosmetics industry created the beauty myth for women through advertising. A cosmetic ad in Indonesia has spread a new concept of white skin: East Asia beauty myth. The white concept of Asia white skin basically derived from colonial legacy. The purpose of the research was analyzing the beauty myth in Indonesia ads using postcolonial perspective. The principal result brought the discourse analysis and postcolonial perspective a new insight in communication research. Particularly on media and cultural studies. Major conclusions showed that the beauty myth since the Dutch colonial period never been change. The main concept is always in colonialism’s idea: “white is better”. The West is better than the East.

  11. Management job ads

    DEFF Research Database (Denmark)

    Holmgreen, Lise-Lotte

    2014-01-01

    jobs by discursively constructing job ads that appeal to both sexes. This argument is part of the broader field of corporate social responsibility, corporate citizenship, and stakeholder management, which involves discussions of the obligations of corporations to acknowledge and mitigate......The article asks whether it is not the responsibility of corporations to address the issue of women being underrepresented in Danish management jobs. In other words, it is argued that corporations should be encouraged to engage more actively in the recruitment of both men and women for management...... the increasingly widespread impact that their activities have on communities and social structures. The article emphasises the need for more active engagement on the part of corporations by analysing the discursive construction of preferred candidates in a small sample of Danish management job ads. By means...

  12. Philosophia ad bellum

    Directory of Open Access Journals (Sweden)

    Yu. O. Loboda

    2014-06-01

    Full Text Available In the paper «Philosophia ad bellum» is being realized an attempt to classify philosophic approaches to the study of phenomenon of war by the analogy with the structure of «Just war theory» – 1. Philosophia ad bellum – «philosophy for war», where are investigated ways of using of philosophic methods of cognition in applied military sciences; 2. Philosophia supra bello – «philosophy above war», which investigates world­view, historic­philosophic, existential, logic­epistemological aspects of war; 3. Philosophia contra belli – «philosophy against war», where research of the essence of war gets its logical conclusion in grounding of the absurdity of thinking schemes which justify war as an act of violence. In the article was made historic­philosophic overview of the part «Philosophia ad bellum», where were showed tangent questions, which are considered by philosophic logic and theory of strategic intelligence. It was stated, that specialists if military intelligence admit the important role of researches in logic and theory of cognition in their professional work; were defined basic questions, which have the most essential interest for military professionals. There were analyzed ways of using of philosophic methods in developing military strategies, was made a conclusion that philosophy can be a basis of strategic failures and victories as well.

  13. AdS 3-manifolds and Higgs bundles

    DEFF Research Database (Denmark)

    Alessandrini, Daniele; Li, Qiongling

    2017-01-01

    In this paper we investigate the relationships between closed AdS $3$-manifolds and Higgs bundles. We have a new way to construct AdS structures that allows us to see many of their properties explicitly, for example we can recover the very recent formula by Tholozan for their volume. We give natu...

  14. Dressing phases of AdS3/CFT2

    NARCIS (Netherlands)

    Borsato, R.; Olsson Sax, O.E.; Sfondrini, A.; Stefanski, B.; Torrielli, A.

    2013-01-01

    We determine the all-loop dressing phases of the AdS3/CFT2 integrable system related to type IIB string theory on AdS3×S3×T4 by solving the recently found crossing relations and studying their singularity structure. The two resulting phases present a novel structure with respect to the ones

  15. Value-Added Exchange Rates

    OpenAIRE

    Rudolfs Bems; Robert C. Johnson

    2012-01-01

    This paper updates the conceptual foundations for measuring real effective exchange rates (REERs) to allow for vertical specialization in trade. We derive a value-added REER describing how demand for the value added that a country produces changes as the price of its value added changes relative to competitors. We then compute this index for 42 countries from 1970-2009 using trade measured in value added terms and GDP deflators. There are substantial differences between value-added and conven...

  16. Wireless Ad Hoc Networks

    Directory of Open Access Journals (Sweden)

    Hong-Chuan Yang

    2007-01-01

    Full Text Available We study the energy-efficient configuration of multihop paths with automatic repeat request (ARQ mechanism in wireless ad hoc networks. We adopt a cross-layer design approach and take both the quality of each radio hop and the battery capacity of each transmitting node into consideration. Under certain constraints on the maximum tolerable transmission delay and the required packet delivery ratio, we solve optimization problems to jointly schedule the transmitting power of each transmitting node and the retransmission limit over each hop. Numerical results demonstrate that the path configuration methods can either significantly reduce the average energy consumption per packet delivery or considerably extend the average lifetime of the multihop route.

  17. A synonymic list of names associated with western Palaearctic Melitaea phoebe (Denis & Schiffermüller, 1775) species group taxa (M. phoebe; M. punica Oberthür, 1876; M. ornata Christoph, 1893) (Lepidoptera, Nymphalidae)

    OpenAIRE

    Russell, Peter; Tennent, W. John

    2016-01-01

    Following indecision and confusion in the literature regarding nomenclature and distribution of Melitaea phoebe (Denis & Schiffermüller, 1775) and its closely associated congeners M. punica Oberthür, 1876, and M. ornata Christoph, 1893, a synonymic list of phoebe names, and of names both correctly and mistakenly associated with phoebe species-group taxa, is presented. Explanatory footnotes provide the basis of a stable source for future discussion of M. phoebe species-group populations throug...

  18. Value Added in English Schools

    OpenAIRE

    Andrew Ray; Tanya McCormack; Helen Evans

    2009-01-01

    Value-added indicators are now a central part of school accountability in England, and value-added information is routinely used in school improvement at both the national and the local levels. This article describes the value-added models that are being used in the academic year 2007–8 by schools, parents, school inspectors, and other professionals in local and national governments. The article outlines the development of value-added models in England following the introduction of national t...

  19. Value Added in English Schools

    Science.gov (United States)

    Ray, Andrew; McCormack, Tanya; Evans, Helen

    2009-01-01

    Value-added indicators are now a central part of school accountability in England, and value-added information is routinely used in school improvement at both the national and the local levels. This article describes the value-added models that are being used in the academic year 2007-8 by schools, parents, school inspectors, and other…

  20. AdS Black Hole with Phantom Scalar Field

    Directory of Open Access Journals (Sweden)

    Limei Zhang

    2017-01-01

    Full Text Available We present an AdS black hole solution with Ricci flat horizon in Einstein-phantom scalar theory. The phantom scalar fields just depend on the transverse coordinates x and y, which are parameterized by the parameter α. We study the thermodynamics of the AdS phantom black hole. Although its horizon is a Ricci flat Euclidean space, we find that the thermodynamical properties of the black hole solution are qualitatively the same as those of AdS Schwarzschild black hole. Namely, there exists a minimal temperature and the large black hole is thermodynamically stable, while the smaller one is unstable, so there is a so-called Hawking-Page phase transition between the large black hole and the thermal gas solution in the AdS space-time in Poincare coordinates. We also calculate the entanglement entropy for a strip geometry dual to the AdS phantom black holes and find that the behavior of the entanglement entropy is qualitatively the same as that of the black hole thermodynamical entropy.

  1. Revisiting the thermodynamic relations in AdS /CMT models

    Science.gov (United States)

    Hyun, Seungjoon; Park, Sang-A.; Yi, Sang-Heon

    2017-03-01

    Motivated by the recent unified approach to the Smarr-like relation of anti-de Sitter (AdS) planar black holes in conjunction with the quasilocal formalism on conserved charges, we revisit the quantum statistical and thermodynamic relations of hairy AdS planar black holes. By extending the previous results, we identify the hairy contribution in the bulk and show that the holographic computation can be improved so that it is consistent with the bulk computation. We argue that the first law can be retained in its universal form and that the relation between the on-shell renormalized Euclidean action and its free energy interpretation in gravity may also be undeformed even with the hairy contribution in hairy AdS black holes.

  2. Asymptotically AdS spacetimes with a timelike Kasner singularity

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Jie [Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel)

    2016-07-21

    Exact solutions to Einstein’s equations for holographic models are presented and studied. The IR geometry has a timelike cousin of the Kasner singularity, which is the less generic case of the BKL (Belinski-Khalatnikov-Lifshitz) singularity, and the UV is asymptotically AdS. This solution describes a holographic RG flow between them. The solution’s appearance is an interpolation between the planar AdS black hole and the AdS soliton. The causality constraint is always satisfied. The entanglement entropy and Wilson loops are discussed. The boundary condition for the current-current correlation function and the Laplacian in the IR is examined. There is no infalling wave in the IR, but instead, there is a normalizable solution in the IR. In a special case, a hyperscaling-violating geometry is obtained after a dimensional reduction.

  3. In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders.

    Directory of Open Access Journals (Sweden)

    Maya Mathew

    Full Text Available Inhibition of Acetylcholinesterase (AChE is still considered as the main therapeutic strategy against Alzheimer's disease (AD. Many plant derived phytochemicals have shown AChE inhibitory activity in addition to the currently approved drugs for AD. In the present study, methanolic extracts of 20 plants used in Indian Ayurvedic system of medicine for improving cognitive function were screened for acetylcholinesterase inhibitory activity by Ellman's microplate colorimetric method. Out of 20 extracts, Emblica officinalis, Nardostachys jatamansi, Nelumbo nucifera, Punica granatum and Raulfia Serpentina showed IC50 values <100 µg/ml for acetylcholinesterase inhibitory activity. Antioxidant activities of these plants were assessed by DPPH scavenging assay. Among the extracts used, antioxidant activity was highest for Terminalia chebula and Emblica officinalis with IC50 values <10 µg/ml. Considering the complex multifactorial etiology of AD, these plant extracts will be safer and better candidates for the future disease modifying therapies against this devastating disease.

  4. Holography in Lovelock Chern-Simons AdS gravity

    Science.gov (United States)

    Cvetković, Branislav; Miskovic, Olivera; Simić, Dejan

    2017-08-01

    We analyze holographic field theory dual to Lovelock Chern-Simons anti-de Sitter (AdS) gravity in higher dimensions using first order formalism. We first find asymptotic symmetries in the AdS sector showing that they consist of local translations, local Lorentz rotations, dilatations and non-Abelian gauge transformations. Then, we compute 1-point functions of energy-momentum and spin currents in a dual conformal field theory and write Ward identities. We find that the holographic theory possesses Weyl anomaly and also breaks non-Abelian gauge symmetry at the quantum level.

  5. AdS5 magnetized solutions in minimal gauged supergravity

    Science.gov (United States)

    Blázquez-Salcedo, Jose Luis; Kunz, Jutta; Navarro-Lérida, Francisco; Radu, Eugen

    2017-08-01

    We construct a generalization of the AdS charged rotating black holes with two equal magnitude angular momenta in five-dimensional minimal gauged supergravity. In addition to the mass, electric charge and angular momentum, the new solutions possess an extra-parameter associated with a non-zero magnitude of the magnetic potential at infinity. In contrast with the known cases, these new black holes possess a non-trivial zero-horizon size limit which describes a one parameter family of spinning charged solitons. All configurations reported in this work approach asymptotically an AdS5 spacetime in global coordinates and are free of pathologies.

  6. AdS5 magnetized solutions in minimal gauged supergravity

    Directory of Open Access Journals (Sweden)

    Jose Luis Blázquez-Salcedo

    2017-08-01

    Full Text Available We construct a generalization of the AdS charged rotating black holes with two equal magnitude angular momenta in five-dimensional minimal gauged supergravity. In addition to the mass, electric charge and angular momentum, the new solutions possess an extra-parameter associated with a non-zero magnitude of the magnetic potential at infinity. In contrast with the known cases, these new black holes possess a non-trivial zero-horizon size limit which describes a one parameter family of spinning charged solitons. All configurations reported in this work approach asymptotically an AdS5 spacetime in global coordinates and are free of pathologies.

  7. Loops in AdS from conformal field theory

    Science.gov (United States)

    Aharony, Ofer; Alday, Luis F.; Bissi, Agnese; Perlmutter, Eric

    2017-07-01

    We propose and demonstrate a new use for conformal field theory (CFT) crossing equations in the context of AdS/CFT: the computation of loop amplitudes in AdS, dual to non-planar correlators in holographic CFTs. Loops in AdS are largely unexplored, mostly due to technical difficulties in direct calculations. We revisit this problem, and the dual 1 /N expansion of CFTs, in two independent ways. The first is to show how to explicitly solve the crossing equations to the first subleading order in 1 /N 2, given a leading order solution. This is done as a systematic expansion in inverse powers of the spin, to all orders. These expansions can be resummed, leading to the CFT data for finite values of the spin. Our second approach involves Mellin space. We show how the polar part of the four-point, loop-level Mellin amplitudes can be fully reconstructed from the leading-order data. The anomalous dimensions computed with both methods agree. In the case of ϕ 4 theory in AdS, our crossing solution reproduces a previous computation of the one-loop bubble diagram. We can go further, deriving the four-point scalar triangle diagram in AdS, which had never been computed. In the process, we show how to analytically derive anomalous dimensions from Mellin amplitudes with an infinite series of poles, and discuss applications to more complicated cases such as the N = 4 super-Yang-Mills theory.

  8. Black Hole Astrophysics in AdS Braneworlds

    CERN Document Server

    Emparan, R; Kaloper, Nemanja; Emparan, Roberto; Garcia-Bellido, Juan; Kaloper, Nemanja

    2003-01-01

    We consider astrophysics of large black holes localized on the brane in the infinite Randall-Sundrum model. Using their description in terms of a conformal field theory (CFT) coupled to gravity, deduced in Ref. [1], we show that they undergo a period of rapid decay via Hawking radiation of CFT modes. For example, a black hole of mass ${\\rm few} \\times M_\\odot$ would shed most of its mass in $\\sim 10^4 - 10^5$ years if the AdS radius is $L \\sim 10^{-1}$ mm, currently the upper bound from table-top experiments. Since this is within the mass range of X-ray binary systems containing a black hole, the evaporation enhanced by the hidden sector CFT modes could cause the disappearance of X-ray sources on the sky. This would be a striking signature of RS2 with a large AdS radius. Alternatively, for shorter AdS radii, the evaporation would be slower. In such cases, the persistence of X-ray binaries with black holes already implies an upper bound on the AdS radius of $L \\la 10^{-2}$ mm, an order of magnitude better than...

  9. Logarithmic AdS waves and Zwei-Dreibein gravity

    NARCIS (Netherlands)

    Bergshoeff, Eric A.; Goya, Andres F.; Merbis, Wout; Rosseel, Jan

    2014-01-01

    We show that the parameter space of Zwei-Dreibein Gravity (ZDG) in AdS(3) exhibits critical points, where massive graviton modes coincide with pure gauge modes and new 'logarithmic' modes appear, similar to what happens in New Massive Gravity. The existence of critical points is shown both at the

  10. Internet Advertising. Google AdWords versus Facebook Ads

    OpenAIRE

    Paul PAŞCU

    2014-01-01

    This article describes how to use the applications for Internet advertising, Google AdWords and Facebook Ads. Our attempt is to present the advantages and disadvantages of each of them, the costs and benefits, a useful aspect for companies that plan to start advertising campaigns on the Internet.

  11. Internet Advertising. Google AdWords versus Facebook Ads

    Directory of Open Access Journals (Sweden)

    Paul PAŞCU

    2014-05-01

    Full Text Available This article describes how to use the applications for Internet advertising, Google AdWords and Facebook Ads. Our attempt is to present the advantages and disadvantages of each of them, the costs and benefits, a useful aspect for companies that plan to start advertising campaigns on the Internet.

  12. Ultraviolet asymptotics for quasiperiodic AdS_4 perturbations

    CERN Document Server

    Craps, Ben; Jai-akson, Puttarak; Vanhoof, Joris

    2015-01-01

    Spherically symmetric perturbations in AdS-scalar field systems of small amplitude epsilon approximately periodic on time scales of order 1/epsilon^2 (in the sense that no significant transfer of energy between the AdS normal modes occurs) have played an important role in considerations of AdS stability. They are seen as anchors of stability islands where collapse of small perturbations to black holes does not occur. (This collapse, if it happens, typically develops on time scales of the order 1/epsilon^2.) We construct an analytic treatment of the frequency spectra of such quasiperiodic perturbations, paying special attention to the large frequency asymptotics. For the case of a self-interacting phi^4 scalar field in a non-dynamical AdS background, we arrive at a fairly complete analytic picture involving quasiperiodic spectra with an exponential suppression modulated by a power law at large mode numbers. For the case of dynamical gravity, the structure of the large frequency asymptotics is more complicated....

  13. AdS sub 2 supergravity and superconformal quantum mechanics

    CERN Document Server

    Astorino, M; Klemm, D; Zanon, D

    2003-01-01

    We investigate the asymptotic dynamics of topological anti-de Sitter supergravity in two dimensions. Starting from the formulation as a BF theory, it is shown that the AdS sub 2 boundary conditions imply that the asymptotic symmetries form a super-Virasoro algebra. Using the central charge of this algebra in Cardy's formula, we exactly reproduce the thermodynamical entropy of AdS sub 2 black holes. Furthermore, we show that the dynamics of the dilaton and its superpartner reduces to that of superconformal transformations that leave invariant one chiral component of the stress tensor supercurrent of a two-dimensional conformal field theory. This dynamics is governed by a supersymmetric extension of the de Alfaro-Fubini-Furlan model of conformal quantum mechanics. Finally, two-dimensional de Sitter gravity is also considered, and the dS sub 2 entropy is computed by counting CFT states.

  14. Entropy function and attractors for AdS black holes

    CERN Document Server

    Morales, J F; Morales, Jose F.; Samtleben, Henning

    2006-01-01

    We apply Sen's entropy formalism to the study of the near horizon geometry and the entropy of asymptotically AdS black holes in gauged supergravities. In particular, we consider non-supersymmetric electrically charged black holes with AdS_2 xS^{d-2} horizons in U(1)^4 and U(1)^3 gauged supergravities in d=4 and d=5 dimensions, respectively. We study several cases including static/rotating, BPS and non-BPS black holes in Einstein as well as in Gauss-Bonnet gravity. In all examples, the near horizon geometry and black hole entropy are derived by extremizing the entropy function and are given entirely in terms of the gauge coupling, the electric charges and the angular momentum of the black hole.

  15. AdS gravity and the scalar glueball spectrum

    Energy Technology Data Exchange (ETDEWEB)

    Vento, Vicente [Departament de Fisica Teorica, Universitat de Valencia y Institut de Fisica Corpuscular, Consejo Superior de Investigaciones Cientificas, Burjassot (Valencia) (Spain)

    2017-09-15

    The scalar glueball spectrum has attracted much attention since the formulation of Quantum Chromodynamics. Different approaches give very different results for the glueball masses. We revisit the problem from the perspective of the AdS/CFT correspondence. (orig.)

  16. The Mixed Phase of Charged AdS Black Holes

    Directory of Open Access Journals (Sweden)

    Piyabut Burikham

    2016-01-01

    Full Text Available We study the mixed phase of charged AdS black hole and radiation when the total energy is fixed below the threshold to produce a stable charged black hole branch. The coexistence conditions for the charged AdS black hole and radiation are derived for the generic case when radiation particles carry charge. The phase diagram of the mixed phase is demonstrated for both fixed potential and charge ensemble. In the dual gauge picture, they correspond to the mixed phase of quark-gluon plasma (QGP and hadron gas in the fixed chemical potential and density ensemble, respectively. In the nuclei and heavy-ion collisions at intermediate energies, the mixed phase of exotic QGP and hadron gas could be produced. The mixed phase will condense and evaporate into the hadron gas as the fireball expands.

  17. Conserved higher-spin charges in AdS4

    Directory of Open Access Journals (Sweden)

    O.A. Gelfond

    2016-03-01

    Full Text Available Gauge invariant conserved conformal currents built from massless fields of all spins in 4d Minkowski space–time and AdS4 are described in the unfolded dynamics approach. The current cohomology associated with non-zero conserved charges is found. The resulting list of charges is shown to match the space of parameters of the conformal higher-spin symmetry algebra in four dimensions.

  18. Generalised structures for N=1 AdS backgrounds

    Energy Technology Data Exchange (ETDEWEB)

    Coimbra, André [Institut für Theoretische Physik & Center for Quantum Engineering and Spacetime Research,Leibniz Universität Hannover,Appelstraße 2, 30167 Hannover (Germany); Strickland-Constable, Charles [Institut de physique théorique, Université Paris Saclay, CEA, CNRS, Orme des Merisiers, F-91191 Gif-sur-Yvette (France)

    2016-11-16

    We expand upon a claim made in a recent paper [http://arxiv.org/abs/1411.5721] that generic minimally supersymmetric AdS backgrounds of warped flux compactifications of Type II and M theory can be understood as satisfying a straightforward weak integrability condition in the language of E{sub d(d)}×ℝ{sup +} generalised geometry. Namely, they are spaces admitting a generalised G-structure set by the Killing spinor and with constant singlet generalised intrinsic torsion.

  19. ADS Bumblebee comes of age

    Science.gov (United States)

    Accomazzi, Alberto; Kurtz, Michael J.; Henneken, Edwin; Grant, Carolyn S.; Thompson, Donna M.; Chyla, Roman; McDonald, Steven; Shaulis, Taylor J.; Blanco-Cuaresma, Sergi; Shapurian, Golnaz; Hostetler, Timothy W.; Templeton, Matthew R.; Lockhart, Kelly E.

    2018-01-01

    The ADS Team has been working on a new system architecture and user interface named “ADS Bumblebee” since 2015. The new system presents many advantages over the traditional ADS interface and search engine (“ADS Classic”). A new, state of the art search engine features a number of new capabilities such as full-text search, advanced citation queries, filtering of results and scalable analytics for any search results. Its services are built on a cloud computing platform which can be easily scaled to match user demand. The Bumblebee user interface is a rich javascript application which leverages the features of the search engine and integrates a number of additional visualizations such as co-author and co-citation networks which provide a hierarchical view of research groups and research topics, respectively. Displays of paper analytics provide views of the basic article metrics (citations, reads, and age). All visualizations are interactive and provide ways to further refine search results. This new search system, which has been in beta for the past three years, has now matured to the point that it provides feature and content parity with ADS Classic, and has become the recommended way to access ADS content and services. Following a successful transition to Bumblebee, the use of ADS Classic will be discouraged starting in 2018 and phased out in 2019. You can access our new interface at https://ui.adsabs.harvard.edu

  20. Ad skepticisms: Antecedents and consequences

    Directory of Open Access Journals (Sweden)

    Rafique Ahmed

    2016-11-01

    Full Text Available Engaging customer is the burning issue for companies especially the service sector, either online or offline. Minimizing the customer disengagement is the same like reducing dissatisfaction or churn. Customer disengagement may be caused by many factors, ad skepticism is one of them; ad skepticism has two main antecedents personality variable and consumption/influencing varia-bles. This research explores the relationship of ad skepticism with customer disengagement through personality variables which are cynicism, reactance and self-esteem. The unit of analysis is the telecom and banking industry of Pakistan which is foreseeing an era of virtual currency and both are customer oriented industries. Only offline disengagement is researched and data is collected from the Business centers of telecom and banking branches dealing with virtual curren-cy in Pakistan. Hypothetical model is given after digging the relevant literature; model is tested through confirmatory factor analysis and structural equation modeling. Eight hypotheses were purposed from the connections of model, all hypotheses are accepted except the cynicism posi-tive effect on social ad skepticism. This can be due to commonality of social and charity in Paki-stani society, Muslims consider charity as a pious act and they do not think for cynic behavior in charity or social related works. The results manifest that customers in telecom industry are hav-ing ad skepticism and that is becoming the cause of their disengagement. Further, social ad skep-ticism has more impact on the customer disengagement than the general ad skepticism. While the reactance has more effect on general ad skepticism than other antecedents and cynicism has the lowest impact on social ad skepticism than other antecedents.

  1. Genetic Structure and Population Demographic History of a Widespread Mangrove Plant Xylocarpus granatum J. Koenig across the Indo-West Pacific Region

    Directory of Open Access Journals (Sweden)

    Yuki Tomizawa

    2017-12-01

    Full Text Available Xylocarpus granatum J. Koenig is one of the most widespread core component species of mangrove forests in the Indo-West Pacific (IWP region, and as such is suitable for examining how genetic structure is generated across spatiotemporal scales. We evaluated the genetic structure of this species using maternally inherited chloroplast (cp and bi-parentally inherited nuclear DNA markers, with samples collected across the species range. Both cp and nuclear DNA showed generally similar patterns, revealing three genetic groups in the Indian Ocean, South China Sea (with Palau, and Oceania, respectively. The genetic diversity of the Oceania group was significantly lower, and the level of population differentiation within the Oceania group was significantly higher, than in the South China Sea group. These results revealed that in addition to the Malay Peninsula—a common land barrier for mangroves—there is a genetic barrier in an oceanic region of the West Pacific that prevents gene flow among populations. Moreover, demographic inference suggested that these patterns were generated in relation to sea level changes during the last glacial period and the emergence of Sahul Shelf which lied northwest of Australia. We propose that the three genetic groups should be considered independent conservation units, and that the Oceania group has a higher conservation priority.

  2. ADS/CFT and QCD

    Energy Technology Data Exchange (ETDEWEB)

    Brodsky, Stanley J.; /SLAC; de Teramond, Guy F.; /Costa Rica U. /SLAC

    2007-02-21

    The AdS/CFT correspondence between string theory in AdS space and conformal .eld theories in physical spacetime leads to an analytic, semi-classical model for strongly-coupled QCD which has scale invariance and dimensional counting at short distances and color confinement at large distances. Although QCD is not conformally invariant, one can nevertheless use the mathematical representation of the conformal group in five-dimensional anti-de Sitter space to construct a first approximation to the theory. The AdS/CFT correspondence also provides insights into the inherently non-perturbative aspects of QCD, such as the orbital and radial spectra of hadrons and the form of hadronic wavefunctions. In particular, we show that there is an exact correspondence between the fifth-dimensional coordinate of AdS space z and a specific impact variable {zeta} which measures the separation of the quark and gluonic constituents within the hadron in ordinary space-time. This connection allows one to compute the analytic form of the frame-independent light-front wavefunctions, the fundamental entities which encode hadron properties and allow the computation of decay constants, form factors, and other exclusive scattering amplitudes. New relativistic lightfront equations in ordinary space-time are found which reproduce the results obtained using the 5-dimensional theory. The effective light-front equations possess remarkable algebraic structures and integrability properties. Since they are complete and orthonormal, the AdS/CFT model wavefunctions can also be used as a basis for the diagonalization of the full light-front QCD Hamiltonian, thus systematically improving the AdS/CFT approximation.

  3. Maximal temperature of a gas in AdS spacetime

    Science.gov (United States)

    Dai, De-Chang; Stojkovic, Dejan

    2017-04-01

    Assuming only statistical mechanics and general relativity, we calculate the maximal temperature of gas of particles placed in anti-de Sitter (AdS) spacetime. If two particles with a given center of mass energy come close enough, according to classical gravity, they will form a black hole. We focus only on the black holes with a Hawking temperature lower than the environment, because they do not disappear. The number density of such black holes grows with the temperature in the system. At a certain finite temperature, the thermodynamical system will be dominated by black holes. This critical temperature is lower than the Planck temperature for the values of the AdS vacuum energy density below the Planck density. This result might be interesting from the AdS/CFT correspondence point of view, since it is different from the Hawking-Page phase transition, and it is not immediately clear what effect dynamically limits the maximal temperature of the thermal state on the CFT side of the correspondence.

  4. Fermionic currents in AdS spacetime with compact dimensions

    Science.gov (United States)

    Bellucci, S.; Saharian, A. A.; Vardanyan, V.

    2017-09-01

    We derive a closed expression for the vacuum expectation value (VEV) of the fermionic current density in a (D +1 )-dimensional locally AdS spacetime with an arbitrary number of toroidally compactified Poincaré spatial dimensions and in the presence of a constant gauge field. The latter can be formally interpreted in terms of a magnetic flux treading the compact dimensions. In the compact subspace, the field operator obeys quasiperiodicity conditions with arbitrary phases. The VEV of the charge density is zero and the current density has nonzero components along the compact dimensions only. They are periodic functions of the magnetic flux with the period equal to the flux quantum and tend to zero on the AdS boundary. Near the horizon, the effect of the background gravitational field is small and the leading term in the corresponding asymptotic expansion coincides with the VEV for a massless field in the locally Minkowski bulk. Unlike the Minkowskian case, in the system consisting of an equal number of fermionic and scalar degrees of freedom, with same masses, charges and phases in the periodicity conditions, the total current density does not vanish. In these systems, the leading divergences in the scalar and fermionic contributions on the horizon are canceled and, as a consequence of that, the charge flux, integrated over the coordinate perpendicular to the AdS boundary, becomes finite. We show that in odd spacetime dimensions the fermionic fields realizing two inequivalent representations of the Clifford algebra and having equal phases in the periodicity conditions give the same contribution to the VEV of the current density. Combining the contributions from these fields, the current density in odd-dimensional C -,P - and T -symmetric models are obtained. As an application, we consider the ground state current density in curved carbon nanotubes described in terms of a (2 +1 )-dimensional effective Dirac model.

  5. New Features in ADS Labs

    Science.gov (United States)

    Accomazzi, Alberto; Kurtz, M. J.; Henneken, E. A.; Grant, C. S.; Thompson, D.; Di Milia, G.; Luker, J.; Murray, S. S.

    2013-01-01

    The NASA Astrophysics Data System (ADS) has been working hard on updating its services and interfaces to better support our community's research needs. ADS Labs is a new interface built on the old tried-and-true ADS Abstract Databases, so all of ADS's content is available through it. In this presentation we highlight the new features that have been developed in ADS Labs over the last year: new recommendations, metrics, a citation tool and enhanced fulltext search. ADS Labs has long been providing article-level recommendations based on keyword similarity, co-readership and co-citation analysis of its corpus. We have now introduced personal recommendations, which provide a list of articles to be considered based on a individual user's readership history. A new metrics interface provides a summary of the basic impact indicators for a list of records. These include the total and normalized number of papers, citations, reads, and downloads. Also included are some of the popular indices such as the h, g and i10 index. The citation helper tool allows one to submit a set of records and obtain a list of top 10 papers which cite and/or are cited by papers in the original list (but which are not in it). The process closely resembles the network approach of establishing "friends of friends" via an analysis of the citation network. The full-text search service now covers more than 2.5 million documents, including all the major astronomy journals, as well as physics journals published by Springer, Elsevier, the American Physical Society, the American Geophysical Union, and all of the arXiv eprints. The full-text search interface interface allows users and librarians to dig deep and find words or phrases in the body of the indexed articles. ADS Labs is available at http://adslabs.org

  6. Entanglement entropy and duality in AdS4

    Directory of Open Access Journals (Sweden)

    Ioannis Bakas

    2015-07-01

    Full Text Available Small variations of the entanglement entropy δS and the expectation value of the modular Hamiltonian δE are computed holographically for circular entangling curves in the boundary of AdS4, using gravitational perturbations with general boundary conditions in spherical coordinates. Agreement with the first law of thermodynamics, δS=δE, requires that the line element of the entangling curve remains constant. In this context, we also find a manifestation of electric–magnetic duality for the entanglement entropy and the corresponding modular Hamiltonian, following from the holographic energy–momentum/Cotton tensor duality.

  7. Fermionic continuous spin gauge field in (AdS space

    Directory of Open Access Journals (Sweden)

    R.R. Metsaev

    2017-10-01

    Full Text Available Fermionic continuous spin field propagating in (AdS space–time is studied. Gauge invariant Lagrangian formulation for such fermionic field is developed. Lagrangian of the fermionic continuous spin field is constructed in terms of triple gamma-traceless tensor–spinor Dirac fields, while gauge symmetries are realized by using gamma-traceless gauge transformation parameters. It is demonstrated that partition function of fermionic continuous spin field is equal to one. Modified de Donder gauge condition that considerably simplifies analysis of equations of motion is found. Decoupling limits leading to arbitrary spin massless, partial-massless, and massive fermionic fields are studied.

  8. Introducing ADS 2.0

    Science.gov (United States)

    Accomazzi, Alberto; Kurtz, M. J.; Henneken, E. A.; Grant, C. S.; Thompson, D.; Luker, J.; Chyla, R.; Murray, S. S.

    2014-01-01

    In the spring of 1993, the Smithsonian/NASA Astrophysics Data System (ADS) first launched its bibliographic search system. It was known then as the ADS Abstract Service, a component of the larger Astrophysics Data System effort which had developed an interoperable data system now seen as a precursor of the Virtual Observatory. As a result of the massive technological and sociological changes in the field of scholarly communication, the ADS is now completing the most ambitious technological upgrade in its twenty-year history. Code-named ADS 2.0, the new system features: an IT platform built on web and digital library standards; a new, extensible, industrial strength search engine; a public API with various access control capabilities; a set of applications supporting search, export, visualization, analysis; a collaborative, open source development model; and enhanced indexing of content which includes the full-text of astronomy and physics publications. The changes in the ADS platform affect all aspects of the system and its operations, including: the process through which data and metadata are harvested, curated and indexed; the interface and paradigm used for searching the database; and the follow-up analysis capabilities available to the users. This poster describes the choices behind the technical overhaul of the system, the technology stack used, and the opportunities which the upgrade is providing us with, namely gains in productivity and enhancements in our system capabilities.

  9. AdS nonlinear instability: moving beyond spherical symmetry

    Science.gov (United States)

    Dias, Óscar J. C.; Santos, Jorge E.

    2016-12-01

    Anti-de Sitter (AdS) is conjectured to be nonlinear unstable to a weakly turbulent mechanism that develops a cascade towards high frequencies, leading to black hole formation (Dafermos and Holzegel 2006 Seminar at DAMTP (University of Cambridge) available at https://dpmms.cam.ac.uk/~md384/ADSinstability.pdf, Bizon and Rostworowski 2011 Phys. Rev. Lett. 107 031102). We give evidence that the gravitational sector of perturbations behaves differently from the scalar one studied by Bizon and Rostworowski. In contrast with Bizon and Rostworowski, we find that not all gravitational normal modes of AdS can be nonlinearly extended into periodic horizonless smooth solutions of the Einstein equation. In particular, we show that even seeds with a single normal mode can develop secular resonances, unlike the spherically symmetric scalar field collapse studied by Bizon and Rostworowski. Moreover, if the seed has two normal modes, more than one resonance can be generated at third order, unlike the spherical collapse of Bizon and Rostworowski. We also show that weak turbulent perturbative theory predicts the existence of direct and inverse cascades, with the former dominating the latter for equal energy two-mode seeds.

  10. AdS pure spinor superstring in constant backgrounds

    Energy Technology Data Exchange (ETDEWEB)

    Chandia, Osvaldo [Departamento de Ciencias, Facultad de Artes Liberales, Universidad Adolfo Ibáñez,Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez,Diagonal Las Torres 2640, Peñalolén, Santiago (Chile); Bevilaqua, L. Ibiapina [Escola de Ciências e Tecnologia, Universidade Federal do Rio Grande do Norte,Caixa Postal 1524, 59072-970, Natal, RN (Brazil); Vallilo, Brenno Carlini [Facultad de Ciencias Exactas, Departamento de Ciencias Físicas, Universidad Andres Bello,Republica 220, Santiago (Chile)

    2014-06-05

    In this paper we study the pure spinor formulation of the superstring in AdS{sub 5}×S{sup 5} around point particle solutions of the classical equations of motion. As a particular example we quantize the pure spinor string in the BMN background.

  11. Numerical Simulations of Asymptotically AdS Spacetimes

    Science.gov (United States)

    Bantilan, Hans

    In this dissertation, we introduce a numerical scheme to construct asymptotically anti-de Sitter spacetimes with Lorentzian signature, focusing on cases that preserve five-dimensional axisymmetry. We study the field theories that are dual to these spacetimes by appealing to the AdS/CFT correspondence in the regime where the gravity dual is completely described by Einstein gravity. The numerical scheme is based on generalized harmonic evolution, and we begin by obtaining initial data defined on some Cauchy hypersurface. For the study described in this dissertation, we use a scalar field to source deviations from pure AdS5, and obtain data that correspond to highly deformed black holes. We evolve this initial data forward in time, and follow the subsequent ringdown. What is novel about this study is that the initial horizon geometry cannot be considered a small perturbation of the final static horizon, and hence we are probing an initial non-linear phase of the evolution of the bulk spacetime. On the boundary, we find that the dual CFT stress tensor behaves like that of a thermalized N = 4 SYM fluid. We find that the equation of state of this fluid is consistent with conformal invariance, and that its transport coefficients match those previously calculated for an N = 4 SYM fluid via holographic methods. Modulo a brief transient that is numerical in nature, this matching appears to hold from the initial time onwards. We transform these solutions computed in global AdS onto a Minkowski piece of the boundary, and examine the temperature of the corresponding fluid flows. Under this transformation, the spatial profile of temperature at the initial time resembles a Lorentz-flattened pancake centered at the origin of Minkowski space. By interpreting the direction along which the data is flattened as the beam-line direction, our initial data can be thought of as approximating a head-on heavy ion collision at its moment of impact.

  12. Smooth causal patches for AdS black holes

    Science.gov (United States)

    Raju, Suvrat

    2017-06-01

    We review the paradox of low energy excitations of a black hole in anti-de Sitter space (AdS). An appropriately chosen unitary operator in the boundary theory can create a locally strong excitation near the black hole horizon, whose global energy is small as a result of the gravitational redshift. The paradox is that this seems to violate a general rule of statistical mechanics, which states that an operator with energy parametrically smaller than k T cannot create a significant excitation in a thermal system. When we carefully examine the position dependence of the boundary unitary operator that produces the excitation and the bulk observable necessary to detect the anomalously large effect, we find that they do not both fit in a single causal patch. This follows from a remarkable property of position-space AdS correlators that we establish explicitly and resolves the paradox in a generic state of the system, since no combination of observers can both create the excitation and observe its effect. As a special case of our analysis, we show how this resolves the "Born rule" paradox of Marolf and Polchinski [J. High Energy Phys. 01 (2016) 008, 10.1007/JHEP01(2016)008] and we verify our solution using an independent calculation. We then consider boundary states that are finely tuned to display a spontaneous excitation outside the causal patch of the infalling observer, and we propose a version of causal patch complementarity in AdS/CFT that resolves the paradox for such states as well.

  13. ADS-B in space

    DEFF Research Database (Denmark)

    Knudsen, Bjarke Gosvig; Jensen, Morten; Birklykke, Alex

    2014-01-01

    them to the terrestrial receivers. This paper gives an overview of the GATOSS mission and of its highly-sensitive ADS-B software-defined radio receiver payload. Details of the design and implementation of the receiver's decoder are introduced. The first real-life, space-based results show that ADS......-B signals are indeed successfully received in space and retransmitted to a terrestrial station by the GATOSS nano-satellite orbiting at 700+ km altitudes, thus showing that GATOSS is capable of tracking flights, including transoceanic ones, from space....

  14. Adding Value to Indiana's Commodities.

    Science.gov (United States)

    Welch, Mary A., Ed.

    1995-01-01

    Food processing plants are adding value to bulk and intermediate products to sell overseas. The Asian Pacific Rim economies constituted the largest market for consumer food products in 1993. This shift toward consumer food imports in this area is due to more women working outside the home, the internationalization of populations, and dramatic…

  15. Facilities Management and Added Value

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2010-01-01

    Aim: This paper aims to present different models of the concept of the added value of Facilities Management (FM), including the FM Value Map, which forms the basis of research group in EuroFM, and to present some of the results of this research collaboration. Approach and methodology: The paper i...

  16. XopN-T3SS effector of Xanthomonas axonopodis pv. punicae localizes to the plasma membrane and modulates ROS accumulation events during blight pathogenesis in pomegranate.

    Science.gov (United States)

    Kumar, Rishikesh; Soni, Madhvi; Mondal, Kalyan K

    2016-12-01

    Bacterial blight caused by Xanthomonas axonopodis pv. punicae (Xap) is a major disease of pomegranate. Xap secretes effector proteins via type III secretion system (T3SS) to suppress pathogen-associated molecular pattern (PAMP)-triggered plant immunity (PTI). Previously we reported that XopN, a conserved effector of Xap, modulate in planta bacterial growth, and blight disease. In continuation to that here we report the deletion of XopN from Xap caused higher accumulation of reactive oxygen species (ROS) including H2O2 and O2(-). We quantitatively assessed the higher accumulation of H2O2 in pomegranate leaves infiltrated with Xap ΔxopN compared to Xap wild-type. We analysed that 1.5 to 3.3 fold increase in transcript expression of ROS and flg22-inducible genes, namely FRK1, GST1, WRKY29, PR1, PR2 and PR5 in Arabidopsis when challenged with Xap ΔxopN; contrary, the up-regulation of all the genes were compromised when challenged with either Xap wild-type or Xap ΔxopN+xopN. Further, we demonstrated the plasma-membrane based localization of XopN protein both in its natural and experimental hosts. All together, the present study suggested that XopN-T3SS effector of Xap gets localized in the plasma membrane and suppresses ROS-mediated early defense responses during blight pathogenesis in pomegranate. Copyright © 2016 Elsevier GmbH. All rights reserved.

  17. Black holes as bubbles of AdS

    Science.gov (United States)

    Danielsson, U. H.; Dibitetto, G.; Giri, S.

    2017-10-01

    In this paper we propose that bubbles of AdS within Minkowski spacetime, stabilized at a finite radius by stiff matter and an electromagnetic gas, can be an alternative endpoint of gravitational collapse. The bubbles are horizonless with a size up to 12.5% larger than their Schwarzschild radius depending on their charge. We argue that they are stable against small perturbations, and have thermodynamical properties similar to those of real black holes. We provide a realization of the bubbles within string theory that relies on a specific brane intersection giving rise to a shell carrying dissolved charges from lower dimensional D-branes as well as a gas of open strings. We also note that our construction provides a new way of understanding the entropy of Reissner-Nordström black holes in the extremal limit.

  18. Colliding waves on a string in AdS$_3$

    CERN Document Server

    Vegh, David

    2015-01-01

    This paper is concerned with the classical motion of a string in global AdS$_3$. The initially static string stretches between two antipodal points on the boundary circle. Both endpoints are perturbed which creates cusps at a steady rate. The cusps propagate towards the interior where they collide. The behavior of the string depends on the strength of forcing. Three qualitatively different phases can be distinguished: transparent, gray, and black. The transparent region is analogous to a standing wave. In the black phase, there is a horizon on the worldsheet and cusps never reach the other endpoint. The string keeps folding and its length grows linearly over time. In the gray phase, the string still grows linearly. However, cusps do cross to the other side. The transparent and gray regions are separated by a transition point where a logarithmic accumulation of cusps is numerically observed. A simple model reproduces the qualitative behavior of the string in the three phases.

  19. Massless AdS 2 scattering and Bethe ansatz

    Science.gov (United States)

    Fontanella, A.; Torrielli, A.

    2017-09-01

    We first analyse the integrable scattering theory describing the massless excitations of AdS 2 × S 2 × T 6 superstrings in the relativistic limit. The matrix part of the S-matrix is obtained in the BMN limit from the conjectured exact expression, and compared to known S-matrices with N=1 supersymmetry in 1 + 1 dimensions. A dressing factor, yet unknown for the complete theory, is here constructed based on relativistic crossing symmetry. We derive a Bethe-ansatz condition by employing a transfer-matrix technique based on the so-called free-fermion condition. This is known to overcome the problem of lack of a reference state. We then generalise the method to the massless non-relativistic case, and compare the resulting Bethe-ansatz condition with a simple massless limit of the one conjectured by Sorokin, Tseytlin, Wulff and Zarembo.

  20. Thermodynamics of charged Lovelock: AdS black holes

    Energy Technology Data Exchange (ETDEWEB)

    Prasobh, C.B.; Suresh, Jishnu; Kuriakose, V.C. [Cochin University of Science and Technology, Department of Physics, Cochin (India)

    2016-04-15

    We investigate the thermodynamic behavior of maximally symmetric charged, asymptotically AdS black hole solutions of Lovelock gravity. We explore the thermodynamic stability of such solutions by the ordinary method of calculating the specific heat of the black holes and investigating its divergences which signal second-order phase transitions between black hole states. We then utilize the methods of thermodynamic geometry of black hole spacetimes in order to explain the origin of these points of divergence. We calculate the curvature scalar corresponding to a Legendre-invariant thermodynamic metric of these spacetimes and find that the divergences in the black hole specific heat correspond to singularities in the thermodynamic phase space. We also calculate the area spectrum for large black holes in the model by applying the Bohr-Sommerfeld quantization to the adiabatic invariant calculated for the spacetime. (orig.)

  1. Adiabatic pumping solutions in global AdS

    Science.gov (United States)

    Carracedo, Pablo; Mas, Javier; Musso, Daniele; Serantes, Alexandre

    2017-05-01

    We construct a family of very simple stationary solutions to gravity coupled to a massless scalar field in global AdS. They involve a constantly rising source for the scalar field at the boundary and thereby we name them pumping solutions. We construct them numerically in D = 4. They are regular and, generically, have negative mass. We perform a study of linear and nonlinear stability and find both stable and unstable branches. In the latter case, solutions belonging to different sub-branches can either decay to black holes or to limiting cycles. This observation motivates the search for non-stationary exactly timeperiodic solutions which we actually construct. We clarify the role of pumping solutions in the context of quasistatic adiabatic quenches. In D = 3 the pumping solutions can be related to other previously known solutions, like magnetic or translationally-breaking backgrounds. From this we derive an analytic expression.

  2. Worldsheet dilatation operator for the AdS superstring

    Energy Technology Data Exchange (ETDEWEB)

    Ramírez, Israel [Departamento de Física, Universidad Técnica Federico Santa María,Casilla 110-V, Valparaíso (Chile); Institut für Mathematik und Institut für Physik, Humboldt-Universität zu Berlin,IRIS Haus, Zum Großen Windkanal 6, 12489 Berlin (Germany); Vallilo, Brenno Carlini [Departamento de Ciencias Físicas, Universidad Andres Bello,Republica 220, Santiago (Chile)

    2016-05-23

    In this work we propose a systematic way to compute the logarithmic divergences of composite operators in the pure spinor description of the AdS{sub 5}×S{sup 5} superstring. The computations of these divergences can be summarized in terms of a dilatation operator acting on the local operators. We check our results with some important composite operators of the formalism.

  3. Brownian motion in AdS/CFT

    NARCIS (Netherlands)

    de Boer, J.; Hubeny, V.E.; Rangamani, M.; Shigemori, M.

    2009-01-01

    We study Brownian motion and the associated Langevin equation in AdS/CFT. The Brownian particle is realized in the bulk spacetime as a probe fundamental string in an asymptotically AdS black hole background, stretching between the AdS boundary and the horizon. The modes on the string are excited by

  4. Realizing "value-added" metrology

    Science.gov (United States)

    Bunday, Benjamin; Lipscomb, Pete; Allgair, John; Patel, Dilip; Caldwell, Mark; Solecky, Eric; Archie, Chas; Morningstar, Jennifer; Rice, Bryan J.; Singh, Bhanwar; Cain, Jason; Emami, Iraj; Banke, Bill, Jr.; Herrera, Alfredo; Ukraintsev, Vladamir; Schlessinger, Jerry; Ritchison, Jeff

    2007-03-01

    The conventional premise that metrology is a "non-value-added necessary evil" is a misleading and dangerous assertion, which must be viewed as obsolete thinking. Many metrology applications are key enablers to traditionally labeled "value-added" processing steps in lithography and etch, such that they can be considered integral parts of the processes. Various key trends in modern, state-of-the-art processing such as optical proximity correction (OPC), design for manufacturability (DFM), and advanced process control (APC) are based, at their hearts, on the assumption of fine-tuned metrology, in terms of uncertainty and accuracy. These trends are vehicles where metrology thus has large opportunities to create value through the engineering of tight and targetable process distributions. Such distributions make possible predictability in speed-sorts and in other parameters, which results in high-end product. Additionally, significant reliance has also been placed on defect metrology to predict, improve, and reduce yield variability. The necessary quality metrology is strongly influenced by not only the choice of equipment, but also the quality application of these tools in a production environment. The ultimate value added by metrology is a result of quality tools run by a quality metrology team using quality practices. This paper will explore the relationships among present and future trends and challenges in metrology, including equipment, key applications, and metrology deployment in the manufacturing flow. Of key importance are metrology personnel, with their expertise, practices, and metrics in achieving and maintaining the required level of metrology performance, including where precision, matching, and accuracy fit into these considerations. The value of metrology will be demonstrated to have shifted to "key enabler of large revenues," debunking the out-of-date premise that metrology is "non-value-added." Examples used will be from critical dimension (CD

  5. Quantum Black Holes as Holograms in AdS Braneworlds

    CERN Document Server

    Emparan, R; Kaloper, Nemanja; Emparan, Roberto; Fabbri, Alessandro; Kaloper, Nemanja

    2002-01-01

    We propose a new approach for using the AdS/CFT correspondence to study quantum black hole physics. The black holes on a brane in an AdS$_{D+1}$ braneworld that solve the classical bulk equations are interpreted as duals of {\\it quantum-corrected} $D$-dimensional black holes, rather than classical ones, of a conformal field theory coupled to gravity. We check this explicitly in D=3 and D=4. In D=3 we reinterpret the existing exact solutions on a flat membrane as states of the dual 2+1 CFT. We show that states with a sufficiently large mass really are 2+1 black holes where the quantum corrections dress the classical conical singularity with a horizon and censor it from the outside. On a negatively curved membrane, we reinterpret the classical bulk solutions as quantum-corrected BTZ black holes. In D=4 we argue that the bulk solution for the brane black hole should include a radiation component in order to describe a quantum-corrected black hole in the 3+1 dual. Hawking radiation of the conformal field is then ...

  6. Entanglement Entropy of AdS Black Holes

    Directory of Open Access Journals (Sweden)

    Maurizio Melis

    2010-11-01

    Full Text Available We review recent progress in understanding the entanglement entropy of gravitational configurations for anti-de Sitter gravity in two and three spacetime dimensions using the AdS/CFT correspondence. We derive simple expressions for the entanglement entropy of two- and three-dimensional black holes. In both cases, the leading term of the entanglement entropy in the large black hole mass expansion reproduces exactly the Bekenstein-Hawking entropy, whereas the subleading term behaves logarithmically. In particular, for the BTZ black hole the leading term of the entanglement entropy can be obtained from the large temperature expansion of the partition function of a broad class of 2D CFTs on the torus.

  7. Sputnik: ad hoc distributed computation.

    Science.gov (United States)

    Völkel, Gunnar; Lausser, Ludwig; Schmid, Florian; Kraus, Johann M; Kestler, Hans A

    2015-04-15

    In bioinformatic applications, computationally demanding algorithms are often parallelized to speed up computation. Nevertheless, setting up computational environments for distributed computation is often tedious. Aim of this project were the lightweight ad hoc set up and fault-tolerant computation requiring only a Java runtime, no administrator rights, while utilizing all CPU cores most effectively. The Sputnik framework provides ad hoc distributed computation on the Java Virtual Machine which uses all supplied CPU cores fully. It provides a graphical user interface for deployment setup and a web user interface displaying the current status of current computation jobs. Neither a permanent setup nor administrator privileges are required. We demonstrate the utility of our approach on feature selection of microarray data. The Sputnik framework is available on Github http://github.com/sysbio-bioinf/sputnik under the Eclipse Public License. hkestler@fli-leibniz.de or hans.kestler@uni-ulm.de Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  8. Antismoking Ads at the Point of Sale: The Influence of Ad Type and Context on Ad Reactions.

    Science.gov (United States)

    Kim, Annice; Nonnemaker, James; Guillory, Jamie; Shafer, Paul; Parvanta, Sarah; Holloway, John; Farrelly, Matthew

    2017-06-01

    Efforts are underway to educate consumers about the dangers of smoking at the point of sale (POS). Research is limited about the efficacy of POS antismoking ads to guide campaign development. This study experimentally tests whether the type of antismoking ad and the context in which ads are viewed influence people's reactions to the ads. A national convenience sample of 7,812 adult current smokers and recent quitters was randomized to 1 of 39 conditions. Participants viewed one of the four types of antismoking ads (negative health consequences-graphic, negative social consequences-intended emotive, benefits of quitting-informational, benefits of quitting-graphic) in one of the three contexts (alone, next to a cigarette ad, POS tobacco display). We assessed participants' reactions to the ads, including perceived effectiveness, negative emotion, affective dissonance, and motivational reaction. Graphic ads elicited more negative emotion and affective dissonance than benefits of quitting ads. Graphic ads elicited higher perceived effectiveness and more affective dissonance than intended emotive ads. Antismoking ads fared best when viewed alone, and graphic ads were least influenced by the context in which they were viewed. These results suggest that in developing POS campaigns, it is important to consider the competitive pro-tobacco context in which antismoking ads will be viewed.

  9. Ad valorem versus unit taxes

    DEFF Research Database (Denmark)

    Schröder, Philipp J.H.; Sørensen, Allan

    2010-01-01

    Real-world industries are composed from heterogeneous firms and substantial intra-industry reallocations take place, i.e. high productivity firms squeeze out low productivity firms. Previous tax-tool comparisons have not included these central forces of industry structure. This paper examines...... a general equilibrium monopolistic competition model with heterogeneous firms and intra-industry reallocations. We show that the welfare superiority of ad valorem over unit taxes under imperfect competition is not only preserved but amplified. The additional difference between the tools arises because unit...... taxes distort relative prices, which in turn reduces average industry productivity through reallocations (the survival and increased market share of lower productivity firms). Importantly, numerical solutions of the model reveal that the relative welfare loss from using the unit tax increases...

  10. MUSICAL ARRANGEMENT OF MEDIA ADS

    Directory of Open Access Journals (Sweden)

    Chernyshov Alexander V.

    2015-01-01

    Full Text Available The music-compositional principles of commercial and political advertising and also the self-promotion of electronic media (radio, television, Internet are considered in this mediatext: from the elementary beeps, symbolic functions, emblems/logos and musical brands to the sound engineering technology to underscore the product's name and the complex synthesis between music and intra movements and color-light design of frames. Simultaneously examines, how the musical arrangement of ethereal advertising is involved in creation the emotional drama or bravado which reach the level of explicit or associative counterpoint 'music with the advertised object or subject' and which extend to expression of cultural image of all the broadcast channel. The article explores the works of the next genres like infomercial, teleshopping, film-ad, and autonomous commercials that have been produced in European countries or USA.

  11. Adding timing to the VELO

    CERN Document Server

    Mitreska, Biljana

    2017-01-01

    The LHCb experiment is designed to perform high precision measurements of matter-antimatter asymmetries and searches for rare and forbidden decays, with the aim of discovering new and unexpected particles and forces. In 2030 the LHC beam intensity will increase by a factor of 50 compared to current operations. This means increased samples of the particles we need to study, but it also presents experimental challenges. In particular, with current technology it becomes impossible to differentiate the many (>50) separate proton-proton collisions which occur for each bunch crossing.\\\\ In this project a Monte Carlo simulation was developed to model the operation of a silicon pixel vertex detector surrounding the collision region at LHCb, under the conditions expected after 2030, after the second upgrade of the Vertex Locator(VELO).The main goal was studying the effect of adding '4D' detectors which save high-precision timing information, in addition to the usual three spatial coordinates, as charged particles pas...

  12. Topological AdS/CFT

    Science.gov (United States)

    Genolini, Pietro Benetti; Richmond, Paul; Sparks, James

    2017-12-01

    We define a holographic dual to the Donaldson-Witten topological twist of N=2 gauge theories on a Riemannian four-manifold. This is described by a class of asymptotically locally hyperbolic solutions to N=4 gauged supergravity in five dimensions, with the four-manifold as conformal boundary. Under AdS/CFT, minus the logarithm of the partition function of the gauge theory is identified with the holographically renormalized supergravity action. We show that the latter is independent of the metric on the boundary four-manifold, as required for a topological theory. Supersymmetric solutions in the bulk satisfy first order differential equations for a twisted Sp(1) structure, which extends the quaternionic Kähler structure that exists on any Riemannian four-manifold boundary. We comment on applications and extensions, including generalizations to other topological twists.

  13. Enumeration and estimation of insect attack fruits of some cultivars ...

    African Journals Online (AJOL)

    In this study, five cultivars of Punica granatum identified (two of which are endemic, while the other three are new) were grown in certain farms at Al-Taif, Saudi Arabia. Enumeration to the insects attack its' fruits illustrated that, there are three insects, namely, Virchola livia, Ectomyelois ceratonia and Pseudococcus maitimus ...

  14. Anthelmintic properties of traditional African and Caribbean medicinal plants

    DEFF Research Database (Denmark)

    Williams, Andrew R.; Soelberg, Jens; Jäger, Anna

    2016-01-01

    closely related to the human A. lumbricoides. A wide variety of activities were seen in the extracts, from negligible to potent. Extracts from Clausena anisata, Zanthoxylum zanthoxyloides and Punica granatum were identified as the most potent with EC50 values of 74, 97 and 164 mu g/mL, respectively. Our...

  15. Effect Of Walnut Leaf, Coriander And Pomegranate On Blood ...

    African Journals Online (AJOL)

    Mechanism of most of herbal used for diabetes mellitus treatment has not been well defined. This study was performed to investigate hypoglycemic effect of walnut leaf (Juglans regia L.), coriander leaf (Coriandrum sativum L.) or pomegranate seed (Punica granatum L.), and their possible role on pancreatic tissue. Diabetes ...

  16. Pomegranate seed oil rich in conjugated linolenic acids reduces in ...

    African Journals Online (AJOL)

    User

    2016-10-01

    Oct 1, 2016 ... The objective of this study was to determine the effect of pomegranate (Punica granatum L.) seed oil ... stopped, and methane production, pH, volatile fatty acids (VFAs) and microbial counts were measured in the ... Plant oil extracts that are rich in unsaturated fatty acids could alter rumen fermentation. The.

  17. Water stress at the end of the pomegranate fruit ripening permits earlier harvesting and improve fruit quality

    NARCIS (Netherlands)

    Galindo Egea, Alejandro; Calín-Sánchez,; Griñán, I.; Rodríguez, P.; Cruz, Zulma N; Girón, I.F.; Corell, M.; Martínez-Font, R.; Moriana, A.; Carbonell-Barrachina, A.A.; Torrecillas, A.; Hernández, F.

    2017-01-01

    Pomegranate (Punica granatum L.) is a drought tolerant crop, which thrives in the face of scarce water resources, this fact underlines the importance of determining the optimum harvest time to improve the quality of pomegranate fruits. This research was focused on the crop responses to drought

  18. In vivo analgesic activities and safety assessment of Vitis vinifera L ...

    African Journals Online (AJOL)

    Purpose: To investigate the analgesic properties of hydro-alcohol fruit extracts of Vitis vinifera (grape) and Punica granatum (pomegranate) in albino male mice. Methods: The analgesic activity of the fruit extracts was examined in vivo using thermal stimulus assays (tail immersion and hot plate) and chemically-induced ...

  19. Mining microsatellite markers from public expressed sequence tag ...

    Indian Academy of Sciences (India)

    97, e58–e60. Doyle J. J. and Doyle J. L. 1990 Isolation of plant DNA from fresh tissue. Focus 12, 13–15. Hasnaoui N., Buonamici A., Sebastiani F., Mars M., Trifi M. and. Vendramin G. G. 2010 Development and characterization of SSR markers for pomegranate (Punica granatum L.) using an enriched library. Conserv. Genet.

  20. Browse Title Index

    African Journals Online (AJOL)

    ... and safety assessment of Vitis vinifera L and Punica granatum L fruits extracts ... Vol 6, No 2 (2007), In Vivo Evaluation of Antidiarrhoeal Activity of the Seed of .... Vol 13, No 10 (2014), Insecticidal activity of essential oil of Cinnamomum ...

  1. Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria

    OpenAIRE

    Nascimento, Gislene G. F.; Locatelli, Juliana; Paulo C. Freitas; Silva,Giuliana L.

    2000-01-01

    The antimicrobial activity of plant extracts and phytochemicals was evaluated with antibiotic susceptible and resistant microorganisms. In addition, the possible synergistic effects when associated with antibiotics were studied. Extracts from the following plants were utilized: Achillea millifolium (yarrow), Caryophyllus aromaticus (clove), Melissa offficinalis (lemon-balm), Ocimun basilucum (basil), Psidium guajava (guava), Punica granatum (pomegranate), Rosmarinus officinalis (rosemary), Sa...

  2. Swarm motility inhibitory and antioxidant activities of pomegranate peel processed under three drying conditions

    Science.gov (United States)

    Contaminated fruits and vegetables cause global health problems and reduced economic productivity resulting in significant loss to food industry. Pomegranate (Punica granatum) peels provides a rich source of bioactive phytochemicals namely, punicalins (PC: a and ß) punicalagins (PG: a and ß) and ell...

  3. Author Details

    African Journals Online (AJOL)

    Nadia, Zeghad. Vol 16, No 3 (2017) - Articles In vivo analgesic activities and safety assessment of Vitis vinifera L and Punica granatum L fruits extracts. Abstract PDF. ISSN: 1596-9827. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors. OTHER RESOURCES... Journal Quality ...

  4. Inhibition of Growth of Fungi Isolated From Deteriorating Melon ...

    African Journals Online (AJOL)

    BSN

    in chronic diarrhea; dysentery and bronchitis. (Gill, 1992). The bark of the root and stem are used as anthelmintic. It is very effective in the treatment of tapeworm infection. Information on the antimicrobial activity of. Punica granatum is scanty. Cymbopogan citratus (Lemon grass) is a tall tropical grass. The fresh stalks and ...

  5. Aldose Reductase Inhibitory and Antiglycation Activities of Four ...

    African Journals Online (AJOL)

    Thonn., Punica granatum L., and Stevia rebaudiana Bertoni) standardized extracts and their major constituents (morusin, phyllanthin, punicalagin and stevioside) in the treatment of long-term diabetic complications by inhibition of aldose reductase (AR) enzyme and advanced glycation end products (AGEs) formation.

  6. Marginal effects of rural roads and irrigation canals on woody and ...

    African Journals Online (AJOL)

    Plant species richness at the edge of rural road with irrigation canal (37 species) was more than the edge of rural road without irrigation canal (17 species), but the cover value was similar to each other. Punica granatum L. was the most frequent species (more than 80%) on both side of rural road (transect 2 and 3) without ...

  7. Author Details

    African Journals Online (AJOL)

    Banso, A. Vol 21 (2010) - Articles The Effect of Allium Sativum and Xylopia Aethiopica Extracts on the Growth of Fungi in Sweet Potato (Ipomoea Batatas) Juice Abstract PDF · Vol 21 (2010) - Articles Inhibition of Growth of Fungi Isolated From Deteriorating Melon Seed By Extracts of Punica Granatum and Cymbopogon ...

  8. Author Details

    African Journals Online (AJOL)

    Saad, LB. Vol 11, No 3 (2014) - Articles Evaluation of the Antinociceptive Effect of the Ethanolic Extract of Punica Granatum Abstract PDF. ISSN: 0189-6016. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions ...

  9. Author Details

    African Journals Online (AJOL)

    Inabo, HI. Vol 2, No 2 (2009) - Articles Investigation on the bioeffects of ethanol extracts of leaf and stem of Momordica charantia on clinical straing of Escherichia coli and Staphlococcus aureas. Abstract PDF · Vol 4, No 2 (2011) - Articles Antitrypanosomal Potentials of Ethanolic Leaf Extracts of Punica granatum against ...

  10. Assessing wines based on total phenols, phenolic acids and ...

    African Journals Online (AJOL)

    The aim of this study was to investigate the phenolic profile of some red wines produced from native Turkish grape varieties (Vitis vinifera Öküzgözü, V. vinifera Boğazkere and V. vinifera Shiraz) and some red fruit wines produced from pomegranate (Punica granatum L.), myrtle (Myrtus communis L.) and black mulberry ...

  11. Ethnobotanical knowledge and practices of traditional healers in ...

    African Journals Online (AJOL)

    Fidelity value analysis indicated that Allium sativum L. (83.3%), Gomphocarpus integer N.E.Br (80%), Punica granatum L. (75%) and Cordia africana L. (75%) were the most preferred species used for the treatment of abdominal pain, febrile illness, evil spirit and skin lesions, respectively. Moreover, Allium sativum L. was the ...

  12. Ethnomedicine Claim Directed in Silico Prediction of Anticancer ...

    African Journals Online (AJOL)

    2018-01-01

    Jan 1, 2018 ... Punica granatum. Punicaceae. Roman. -Rind of the fruit is boiled with water and taken orally. Abdomen. 9836. Boswellia papyrifera. Burseraceae. Habeket. -Gum of the plant is macerated in cold water which forms a thick gel taken orally. Abdomen. 2053. Osyridocarpus schimperanus. Santacaceae.

  13. Free radical scavenging and cytotoxic activity of five commercial ...

    African Journals Online (AJOL)

    Polygonum cuspidatum), and pomegranate (Punica granatum). It shows radical scavenging activity in the following order, according to their median effective concentration (EC

  14. Author Details

    African Journals Online (AJOL)

    Sadeghi, N. Vol 13, No 6 (2014) - Articles Total Antioxidant Activity, and Hesperidin, Diosmin, Eriocitrin and Quercetin Contents of Various Lemon Juices Abstract PDF · Vol 13, No 7 (2014) - Articles Anti-Ulcerative Potential of Punica granatum L (Lythraceae) Hydroalcohol Fruit Peel Extract Abstract PDF. ISSN: 1596-9827.

  15. Author Details

    African Journals Online (AJOL)

    Osman, RE. Vol 8, No 3 (2013) - Articles Evaluation of Punica granatum Peel Against Diabetic Wound Infection Abstract. ISSN: 1858-5051. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...

  16. Author Details

    African Journals Online (AJOL)

    Maheshwari, K. Vol 6, No 1 (2009) - Articles Protective effects of Punica granatum seeds extract against aging and scopolamine induced cognitive impairments in mice. Abstract PDF. ISSN: 0189-6016. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

  17. Author Details

    African Journals Online (AJOL)

    Abid, M. Vol 10, No 46 (2011) - Articles Selection of pomegranate (Punica granatum L.) in south-eastern Tunisia Abstract PDF. ISSN: 1684-5315. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors. OTHER RESOURCES... Journal Quality · for Researchers · for Journals ...

  18. Inhibition of Growth of Fungi Isolated From Deteriorating Melon ...

    African Journals Online (AJOL)

    A study was conducted to investigate the effect of extracts of Punica granatum and Cymbopogon citratus on Aspergillus nivale, Rhizopus stolonifer , Mucor mucido and Aspergillus fumigatus isolated from deteriorating melon seed using radial growth technique. Phytochemical screening revealed that extracts the plants ...

  19. Author Details

    African Journals Online (AJOL)

    Farouk, L. Vol 26 (2010) - Articles Evaluation des Activities Analgesique et Antipyretique de Punica granatum. Abstract. ISSN: 0303-691X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors. OTHER RESOURCES... Journal Quality · for Researchers · for Journals · for Authors ...

  20. Phytochemical content, antioxidant capacity and physicochemical ...

    African Journals Online (AJOL)

    We investigated the antioxidant and physicochemical properties of pomegranate (Punica granatum cv. Bhagwa) fruit grown in three microclimates in South Africa. The physicochemical properties of fruit peel and arils differed among the growing locations, including weight and redness color of both peel and arils. Contents of ...

  1. Inhibition of Growth of Fungi Isolated From Deteriorating Melon ...

    African Journals Online (AJOL)

    BSN

    Abstract. A study was conducted to investigate the effect of extracts of Punica granatum and. Cymbopogon citratus on Aspergillus nivale, Rhizopus stolonifer , Mucor mucido and. Aspergillus fumigatus isolated from deteriorating melon seed using radial growth technique. Phytochemical screening revealed that extracts the ...

  2. Author Details

    African Journals Online (AJOL)

    Ouachrif, A. Vol 26 (2010) - Articles Evaluation des Activities Analgesique et Antipyretique de Punica granatum. Abstract. ISSN: 0303-691X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...

  3. Seasonal pattern of infestation by the carob moth Ectomyelois ceratoniae in pomegranate cultivars

    NARCIS (Netherlands)

    Hosseini, S.A.; Goldansaz, S.H.; Fotoukkiaii, S.M.; Menken, S.B.J.; Groot, A.T.

    2017-01-01

    Pomegranate (Punica granatum L.) orchards in the Middle East are typically composed of a mix of different cultivars in which variation in fruit infestation by carob moth Ectomyelois ceratoniae (Zeller) (Lepidoptera: Pyralidae) has been observed. However, seasonal variation in infestation and

  4. African Journal of Traditional, Complementary and Alternative ...

    African Journals Online (AJOL)

    Protective effects of Annona muricata linn. (Annonaceae) leaf aqueous extract on serum lipid ... Protective effects of Punica granatum seeds extract against aging and scopolamine induced cognitive impairments in mice · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL ...

  5. Pomegranate seed oil rich in conjugated linolenic acids reduces in ...

    African Journals Online (AJOL)

    The objective of this study was to determine the effect of pomegranate (Punica granatum L.) seed oil (PSO) on gas and methane (CH4) production, ruminal fermentation and microbial populations under in vitro conditions. Three treatments consisting of a control diet containing 10 mg tallow (CON); the control diet with 5 mg ...

  6. Effects of storage conditions on transpiration rate of pomegranate ...

    African Journals Online (AJOL)

    This study investigated the effects of temperature (5, 10, 15 and 22 °C) and relative humidity (RH) (76%, 86% and 96%) on the transpiration rate (TR) of pomegranate (Punica granatum L.) cv. Bhagwa fruit fractions, namely arils and aril-sac. Both temperature and RH had significant effects on the TR of fruit fractions. The TR ...

  7. III Adli Bilimler Kongresi - Posterler

    Directory of Open Access Journals (Sweden)

    Adli Tıp Uzmanları Derneği ATUD

    2000-08-01

    Full Text Available POSTER ÖZETLERİ OTOPSİ UYGULAMASINA TOPLUMSAL YAKLAŞIM C. Haluk İNCE*, Nurhan İNCE** ***, Şebnem Korur FİNCANCI*, Yıldız TÜMERDEM**. ÖZET Otopsi sayısı, bir ülkenin sağlık ve yargı yönünden gelişmişliğinin kriterlerinden biridir. Çalışma bireylerin konu ile ilgili bilgi ve davranışları öğrenildiği takdirde otopsi ile ilgili olumsuz davranışlarının da en aza indirgenecek bir yöntemle eğitilmelerinin sağlanabileceği savı ile gerçekleştirilmiştir. Verileri İstanbul kentinde farklı sosyoekonomik kültürel (SEK düzeyli toplum yapısının gözlendiği ilçelerden rastlantısal örnekleme ile seçilen 342 katılıcıdan çok sorulu anketi (ön seçimli yüzyüze uygulama yöntemi ile toplanmıştır. 342 katılımcının %6l.4 (n=210'ü kadın, %38.6 (n=132'si erkektir. % 9.1 kişinin ailesinde bir otopsi deneyimi yaşamıştır. %76.9 (n:263 kişi otopsinin gerekli olduğunu ifade etmiştir. Bireylerin eğitim durumlarına göre otopsiye izin verme konusundaki görüşlerinin arasında öğrenim düzeyi yüksek olanların lehine istatistiksi açıdan anlamlı sonuç çıkmıştır. Her iki cinste de ailelerinde hangi birey olursa olsun otopsiye rıza konusundaki görüşlerinde farklılığın olmaması dikkat çekici bulunmuştur. % 16.1 (n:5' i ise dini inançlarına aykırı olduğu için otopsiye asla izin veremeyeceklerini ifade etmiştir. Toplumun SEK yapısından kaynaklanan yetersiz bilgi ülkemizdeki otopsi sayısının gelişmiş ülkelere oranla olumsuz etkilemektedir. Ancak hekim ve hekim dışı sağlık çalışanlarının da otopsi konusunda bilgi ve donanımlarını geliştirmeleri gerekmektedir. Bu çalışma otopsi sayısındaki düşüklüğün rolünü araştırmak üzere düzenlenmiştir. Anahtar Kelimeler: Otopsi, toplumsal yargı, bilgilendirme. TRAKTÖR KAZALARINDA ÖLEN OLGULARIN DEĞERLENDİRİLMESİ M.Selim ÖZKÖK*, Ufuk KATKICI. ÖZET Trafik kazaları adli tıp pratiğinde

  8. Recurring Anomaly Detection System (ReADS)

    Data.gov (United States)

    National Aeronautics and Space Administration — Overview: ReADS can analyze text reports, such as aviation reports and problem or maintenance records. ReADS uses text clustering algorithms to group loosely related...

  9. VALUE ADDED IN A LOGISTICS CENTER

    OpenAIRE

    Beata Skowron-Grabowska

    2010-01-01

    In the paper, the author has shown possibilities of creating added value in logistics centre from the theoretical point of view. Value creation in the supply literature commonly builds on the added value models One of such possibilities is preparing hierarchical model of creating added value through prediction of customers’ and enterprises’ in supply chain expectations. Another possibility pointed in the paper is creation of added value due to building special department of transportation and...

  10. Effective ads: new technology answers old questions

    NARCIS (Netherlands)

    L.E. Couwenberg (Linda)

    2017-01-01

    markdownabstractMarketing experts commonly refer to ads as either “emotional” or “rational” in their appeal to consumers. This dichotomy of “thinking versus feeling” is most evident when it comes to discussions around what makes an ad effective. Some studies suggest that an ad that pulls on the

  11. Automated Experiments on Ad Privacy Settings

    Directory of Open Access Journals (Sweden)

    Datta Amit

    2015-04-01

    Full Text Available To partly address people’s concerns over web tracking, Google has created the Ad Settings webpage to provide information about and some choice over the profiles Google creates on users. We present AdFisher, an automated tool that explores how user behaviors, Google’s ads, and Ad Settings interact. AdFisher can run browser-based experiments and analyze data using machine learning and significance tests. Our tool uses a rigorous experimental design and statistical analysis to ensure the statistical soundness of our results. We use AdFisher to find that the Ad Settings was opaque about some features of a user’s profile, that it does provide some choice on ads, and that these choices can lead to seemingly discriminatory ads. In particular, we found that visiting webpages associated with substance abuse changed the ads shown but not the settings page. We also found that setting the gender to female resulted in getting fewer instances of an ad related to high paying jobs than setting it to male. We cannot determine who caused these findings due to our limited visibility into the ad ecosystem, which includes Google, advertisers, websites, and users. Nevertheless, these results can form the starting point for deeper investigations by either the companies themselves or by regulatory bodies.

  12. Contextual advertising using Google AdWords and Google AdSense

    OpenAIRE

    Mihok, Radovan

    2008-01-01

    The thesis introduces contextual advertising on internet using Google AdWords. The paper describes individual steps of an ad campaign (product choosing, ad types, keywords), its management and success evaluation (calculation of ROI and modified ROI).

  13. Thermodynamic Volume in AdS/CFT

    Science.gov (United States)

    Kim, Kyung Kiu; Ahn, Byoungjoon

    2018-01-01

    In this note, we study on extended thermodynamics of AdS black holes by varying cosmological constant. We found and discussed pressure and volume of both bulk and boundary physics through AdS/CFT correspondence. In particular, we derive the relation between thermodynamic volume and a chemical potential for M2 brane dual to four dimensional AdS space. In addition, we show that thermodynamic volume of hyperbolic black hole is related to `entanglement pressure' coming from a generalized first law of entanglement entropy.

  14. Ad-hoc networking towards seamless communications

    CERN Document Server

    Gavrilovska, Liljana

    2006-01-01

    Ad-Hoc Networking Towards Seamless Communications is dedicated to an area that attracts growing interest in academia and industry and concentrates on wireless ad hoc networking paradigm. The persistent efforts to acquire the ability to establish dynamic wireless connections from anywhere to anyone with any device without prerequisite imbedded infrastructure move the communications boundaries towards ad-hoc networks. Recently, ad hoc networking has attracted growing interest due to advances in wireless communications, and developed framework for running IP based protocols. The expected degree of penetration of these networks will depend on the successful resolution of the key features. Ad-hoc networks pose many complex and open problems for researchers. Ad-Hoc Networking Towards Seamless Communications reveals the state-of-the-art in wireless ad-hoc networking and discusses some of the key research topics that are expected to promote and accelerate the commercial applications of these networks (e.g., MAC, rout...

  15. Protein domain organisation: adding order

    Directory of Open Access Journals (Sweden)

    Kummerfeld Sarah K

    2009-01-01

    Full Text Available Abstract Background Domains are the building blocks of proteins. During evolution, they have been duplicated, fused and recombined, to produce proteins with novel structures and functions. Structural and genome-scale studies have shown that pairs or groups of domains observed together in a protein are almost always found in only one N to C terminal order and are the result of a single recombination event that has been propagated by duplication of the multi-domain unit. Previous studies of domain organisation have used graph theory to represent the co-occurrence of domains within proteins. We build on this approach by adding directionality to the graphs and connecting nodes based on their relative order in the protein. Most of the time, the linear order of domains is conserved. However, using the directed graph representation we have identified non-linear features of domain organization that are over-represented in genomes. Recognising these patterns and unravelling how they have arisen may allow us to understand the functional relationships between domains and understand how the protein repertoire has evolved. Results We identify groups of domains that are not linearly conserved, but instead have been shuffled during evolution so that they occur in multiple different orders. We consider 192 genomes across all three kingdoms of life and use domain and protein annotation to understand their functional significance. To identify these features and assess their statistical significance, we represent the linear order of domains in proteins as a directed graph and apply graph theoretical methods. We describe two higher-order patterns of domain organisation: clusters and bi-directionally associated domain pairs and explore their functional importance and phylogenetic conservation. Conclusion Taking into account the order of domains, we have derived a novel picture of global protein organization. We found that all genomes have a higher than expected

  16. III Adli Bilimler Kongresi - Posterler

    Directory of Open Access Journals (Sweden)

    Adli Tıp Uzmanları Derneği ATUD

    1999-12-01

    Full Text Available POSTER ÖZETLERİ ADLİ ÇOCUK OTOPSİLERİ Y.Mustafa KARAGÖZ*, Mehmet ATILGAN*, Sema (Demirçin KARAGÖZ**, Refik AKMAN*. ÖZET Çocukluk döneminde meydana gelen ölümlerin aydınlatılması, sağlık hizmetlerinin yönlendirilmesinde olduğu kadar, yasal açıdan da farklı yaklaşımları gerektirdiğinden büyük önem taşımaktadır. Bu çalışmada çocuk otopsilerine ait verilerden yararlanılarak özellikle ölüm orijinleri ve yöresel farklılıklar açısından çocuk ölümlerinin irdelenmesi amaçlanmıştır. 1987-1996 yılları arasındaki 10 yıllık süre içinde Adli Tıp Kurumu Antalya Şube Müdürlüğü’nde otopsisi yapılan 940 olgudan 18 yaş ve altındaki 172 olgu çalışma kapsamına alınarak yaş grupları, cinsiyet, ölüm nedenleri ve orijinler açısından değerlendirilmiştir. Olguların % 58.1’i erkek, % 4l.9’u kadındır. Ölüm orijinleri arasında ilk sırada kazalar (%34.3 bulunmakta, ardından intiharlar (% 19.2 gelmektedir. Kazalarda % 40.6, intiharlarda % 72.8 olmak üzere her iki gruptaki ölüm nedenleri arasında da pestisit intoksikasyonları ilk sıradadır. Doğal ölümler % 16.9 oranında olup solunum sistemi hastalıkları ön plandadır. 0-4, 5-9, ve 10-14 yaş gruplarında kazalar, 15-18 yaş grubunda ise % 36.7 lik bir oranla intihar orijinli ölümler ilk sırada yer almıştır. GÖĞÜS VE BATINA NAFİZ KESİCİ DELİCİ ALET YARALANMALARINA BAĞLI ÖLÜMLERİN RETROSPEKTİF OLARAK DEĞERLENDİRİLMESİ Süleyman GÖREN, Yaşar TIRAŞÇI. ÖZET Kesici delici aletler günümüzde çok yaygın olarak, çeşitli tip ve nitelikte evlerde ve birçok iş yerinde meslek ve sanat icrası için kullanılmaktadır. Bu aletlerin tip ve nitelikleri salt saldırı ve savunma silahı olarak kullanılan aletleri aratmayacak özelliktedir. Bu nedenle bölgedeki kesici delici alet yaralanması ile ölümler ve demografik özellikleri araştırılmaya değer görülmüştür. 1989 - 1996 y

  17. Joule-Thomson Expansion of Charged AdS Black Holes

    CERN Document Server

    Ökcü, Özgür

    2016-01-01

    In this paper, we study Joule-Thomson effects for charged AdS black holes. We obtain inversion temperatures and curves. We investigate similarities and differences between van der Waals fluids and charged AdS black holes for the expansion. We obtain isenthalpic curves for both systems in $T-P$ plane and determine the cooling-heating regions.

  18. Joule-Thomson expansion of the charged AdS black holes

    Energy Technology Data Exchange (ETDEWEB)

    Oekcue, Oezguer; Aydiner, Ekrem [Istanbul University, Department of Physics, Faculty of Science, Vezneciler, Istanbul (Turkey)

    2017-01-15

    In this paper, we study Joule-Thomson effects for charged AdS black holes. We obtain inversion temperatures and curves. We investigate similarities and differences between van der Waals fluids and charged AdS black holes for the expansion. We obtain isenthalpic curves for both systems in the T-P plane and determine the cooling-heating regions. (orig.)

  19. Static Einstein-Maxwell Black Holes with No Spatial Isometries in AdS Space.

    Science.gov (United States)

    Herdeiro, Carlos A R; Radu, Eugen

    2016-11-25

    We explicitly construct static black hole solutions to the fully nonlinear, D=4, Einstein-Maxwell-anti-de Sitter (AdS) equations that have no continuous spatial symmetries. These black holes have a smooth, topologically spherical horizon (section), but without isometries, and approach, asymptotically, global AdS spacetime. They are interpreted as bound states of a horizon with the Einstein-Maxwell-AdS solitons recently discovered, for appropriate boundary data. In sharp contrast to the uniqueness results for a Minkowski electrovacuum, the existence of these black holes shows that single, equilibrium, black hole solutions in an AdS electrovacuum admit an arbitrary multipole structure.

  20. Effects of ad placement and type on consumer responses to podcast ads.

    Science.gov (United States)

    Ritter, Eric A; Cho, Chang-Hoan

    2009-10-01

    The purpose of this study was to understand the effects of podcast ad placement and podcast ad type on consumers' perceived intrusiveness, perceived irritation, attitude toward the ad, and ad avoidance. Our 2 x 2 (traditional ad vs. sponsorship by beginning vs. middle) experimental study found that sponsorships generated better consumer responses than did traditional ads and that podcast ads placed at the beginning of audio podcasts yielded better consumer responses than those placed in the middle. Implications for marketers and advertisers are discussed.

  1. Scrutiny Heightens for "Value Added" Research Methods

    Science.gov (United States)

    Viadero, Debra

    2008-01-01

    As value-added research designs gain in popularity and undergo increasing scrutiny, experts are beginning to wave cautionary flags about how best to make use of them in education. Value-added techniques for measuring student achievement appeal to administrators and policymakers at all levels of education because they quantify the gains that…

  2. Queueing Models for Mobile Ad Hoc Networks

    NARCIS (Netherlands)

    de Haan, Roland

    2009-01-01

    This thesis presents models for the performance analysis of a recent communication paradigm: \\emph{mobile ad hoc networking}. The objective of mobile ad hoc networking is to provide wireless connectivity between stations in a highly dynamic environment. These dynamics are driven by the mobility of

  3. Validity of Maxwell equal area law for black holes conformally coupled to scalar fields in $$\\text {AdS}_5$$ AdS 5 spacetime

    National Research Council Canada - National Science Library

    Miao, Yan-Gang; Xu, Zhen-Ming

    2017-01-01

    We investigate the $$P{-}V$$ P - V criticality and the Maxwell equal area law for a five-dimensional spherically symmetric AdS black hole with a scalar hair in the absence of and in the presence of a Maxwell field, respectively...

  4. Holographic complexity and fidelity susceptibility as holographic information dual to different volumes in AdS

    Directory of Open Access Journals (Sweden)

    N.S. Mazhari

    2017-03-01

    Full Text Available The holographic complexity and fidelity susceptibility have been defined as new quantities dual to different volumes in AdS. In this paper, we will use these new proposals to calculate both of these quantities for a variety of interesting deformations of AdS. We obtain the holographic complexity and fidelity susceptibility for an AdS black hole, Janus solution, a solution with cylindrical symmetry, an inhomogeneous background and a hyperscaling violating background. It is observed that the holographic complexity depends on the size of the subsystem for all these solutions and the fidelity susceptibility does not have any such dependence.

  5. Holographic complexity and fidelity susceptibility as holographic information dual to different volumes in AdS

    Energy Technology Data Exchange (ETDEWEB)

    Mazhari, N.S., E-mail: najmemazhari86@gmail.com [Eurasian International Center for Theoretical Physics and Department of General & Theoretical Physics, Eurasian National University, Astana 010008 (Kazakhstan); Momeni, Davood, E-mail: davoodmomeni78@gmail.com [Eurasian International Center for Theoretical Physics and Department of General & Theoretical Physics, Eurasian National University, Astana 010008 (Kazakhstan); Bahamonde, Sebastian, E-mail: sebastian.beltran.14@ucl.ac.uk [Department of Mathematics, University College London, Gower Street, London, WC1E 6BT (United Kingdom); Faizal, Mir, E-mail: mirfaizalmir@googlemail.com [Irving K. Barber School of Arts and Sciences, University of British Columbia - Okanagan, 3333 University Way, Kelowna, British Columbia, V1V 1V7 (Canada); Department of Physics and Astronomy, University of Lethbridge, Lethbridge, Alberta, T1K 3M4 (Canada); Myrzakulov, Ratbay, E-mail: rmyrzakulov@gmail.com [Eurasian International Center for Theoretical Physics and Department of General & Theoretical Physics, Eurasian National University, Astana 010008 (Kazakhstan)

    2017-03-10

    The holographic complexity and fidelity susceptibility have been defined as new quantities dual to different volumes in AdS. In this paper, we will use these new proposals to calculate both of these quantities for a variety of interesting deformations of AdS. We obtain the holographic complexity and fidelity susceptibility for an AdS black hole, Janus solution, a solution with cylindrical symmetry, an inhomogeneous background and a hyperscaling violating background. It is observed that the holographic complexity depends on the size of the subsystem for all these solutions and the fidelity susceptibility does not have any such dependence.

  6. Thermodynamic geometry and phase transitions of AdS braneworld black holes

    Energy Technology Data Exchange (ETDEWEB)

    Chaturvedi, Pankaj, E-mail: cpankaj@iitk.ac.in; Sengupta, Gautam, E-mail: sengupta@iitk.ac.in

    2017-02-10

    The thermodynamics and phase transitions of charged RN–AdS and rotating Kerr–AdS black holes in a generalized Randall–Sundrum braneworld are investigated in the framework of thermodynamic geometry. A detailed analysis of the thermodynamics, stability and phase structures in the canonical and the grand canonical ensembles for these AdS braneworld black holes are described. The thermodynamic curvatures for both these AdS braneworld black holes are computed and studied as a function of the thermodynamic variables. Through this analysis we illustrate an interesting dependence of the phase structures on the braneworld parameter for these black holes.

  7. Google Advertising Tools Cashing in with AdSense and AdWords

    CERN Document Server

    Davis, Harold

    2010-01-01

    With this book, you'll learn how to take full advantage of Google AdWords and AdSense, the sophisticated online advertising tools used by thousands of large and small businesses. This new edition provides a substantially updated guide to advertising on the Web, including how it works in general, and how Google's advertising programs in particular help you make money. You'll find everything you need to work with AdWords, which lets you generate text ads to accompany specific search term results, and AdSense, which automatically delivers precisely targeted text and image ads to your website.

  8. Inflation in AdS/CFT

    Energy Technology Data Exchange (ETDEWEB)

    Freivogel, Ben; /Stanford U., Phys. Dept. /LBL, Berkeley; Hubeny, Veronika E.; /LBL, Berkeley /Durham U., Dept. of Math.; Maloney, Alexander; /Stanford U., Phys. Dept.; Myers, Rob; /Perimeter Inst. Theor. Phys. /Waterloo U.; Rangamani, Mukund; /LBL, Berkeley /Durham U., Dept. of Math.; Shenker, Stephen; /Stanford U., Phys. Dept.

    2005-10-07

    We study the realization of inflation within the AdS/CFT correspondence. We assume the existence of a string landscape containing at least one stable AdS vacuum and a (nearby) metastable de Sitter state. Standard arguments imply that the bulk physics in the vicinity of the AdS minimum is described by a boundary CFT. We argue that large enough bubbles of the dS phase, including those able to inflate, are described by mixed states in the CFT. Inflating degrees of freedom are traced over and do not appear explicitly in the boundary description. They nevertheless leave a distinct imprint on the mixed state. Analytic continuation allows us, in principle, to recover a large amount of nonperturbatively defined information about the inflating regime. Our work also shows that no scattering process can create an inflating region, even by quantum tunneling, since a pure state can never evolve into a mixed state under unitary evolution.We study the realization of inflation within the AdS/CFT correspondence. We assume the existence of a string landscape containing at least one stable AdS vacuum and a (nearby) metastable de Sitter state. Standard arguments imply that the bulk physics in the vicinity of the AdS minimum is described by a boundary CFT. We argue that large enough bubbles of the dS phase, including those able to inflate, are described by mixed states in the CFT. Inflating degrees of freedom are traced over and do not appear explicitly in the boundary description. They nevertheless leave a distinct imprint on the mixed state. Analytic continuation allows us, in principle, to recover a large amount of nonperturbatively defined information about the inflating regime. Our work also shows that no scattering process can create an inflating region, even by quantum tunneling, since a pure state can never evolve into a mixed state under unitary evolution.

  9. Collapse and Nonlinear Instability of AdS Space with Angular Momentum

    Science.gov (United States)

    Choptuik, Matthew W.; Dias, Óscar J. C.; Santos, Jorge E.; Way, Benson

    2017-11-01

    We present a numerical study of rotational dynamics in AdS5 with equal angular momenta in the presence of a complex doublet scalar field. We determine that the endpoint of gravitational collapse is a Myers-Perry black hole for high energies and a hairy black hole for low energies. We investigate the time scale for collapse at low energies E , keeping the angular momenta J ∝E in anti-de Sitter (AdS) length units. We find that the inclusion of angular momenta delays the collapse time, but retains a t ˜1 /E scaling. We perturb and evolve rotating boson stars, and find that boson stars near AdS space appear stable, but those sufficiently far from AdS space are unstable. We find that the dynamics of the boson star instability depend on the perturbation, resulting either in collapse to a Myers-Perry black hole, or development towards a stable oscillating solution.

  10. Quantum corrections to short folded superstring in AdS × S × M

    DEFF Research Database (Denmark)

    Beccaria, M.; Macorini, G.

    2013-01-01

    We consider integrable superstring theory on AdS × S × M where M = T or M = S × S with generic ratio of the radii of the two 3-spheres. We compute the one-loop energy of a short folded string spinning in AdS and rotating in S. The computation is performed by world-sheet small spin perturbation...... in the Bethe Ansatz. Remarkably, this contribution E turns out to be independent on the radii ratio. In the M = T limit, we discuss how E relates to a recent proposal for the dressing phase tested in the su(2) sector. We point out some difficulties suggesting that quantization of the AdS classical finite......-gap equations could be subtler than the easier AdS × S case....

  11. Impaired cognition in depression and Alzheimer (AD: a gradient from depression to depression in AD

    Directory of Open Access Journals (Sweden)

    Narahyana Bom de Araujo

    2014-09-01

    Full Text Available Objective To assess cognition in major depressed (MD, Alzheimer's disease (AD, and depression in AD elderly. Method Subjects were evaluated by Mini Mental, Rey Auditory Verbal Learning Test, Rey Complex Figure, Digit Span, Similarities, Trail Making A/B, Verbal Fluency and Stroop. One-way ANOVA and multivariate models were used to compare the performance of each group on neuropsychological tests. Results We evaluated 212 subjects. Compared to MD, attention, working memory, processing speed and recall showed significantly better in controls. Controls showed significantly higher performance in all cognitive measures, except in attention compared to AD. Verbal fluency, memory, processing speed and abstract reasoning in MD was significantly higher compared to AD. AD was significantly better in general cognitive state than depression in AD. All other cognitive domains were similar. Conclusion A decreasing gradient in cognition appeared from the control to depression in AD, with MD and AD in an intermediate position.

  12. Orbiting strings in AdS black holes and N=4 SYM at finite temperature

    CERN Document Server

    Armoni, Adi; Petkou, Anastasios C

    2002-01-01

    Following Gubser, Klebanov and Polyakov [hep-th/0204051], we study strings in AdS black hole backgrounds. With respect to the pure AdS case, rotating strings are replaced by orbiting strings. We interpret these orbiting strings as CFT states of large spin similar to glueballs propagating through a gluon plasma. The energy and the spin of the orbiting string configurations are associated with the energy and the spin of states in the dual finite temperature N=4 SYM theory. We analyse in particular the limiting cases of short and long strings. Moreover, we perform a thermodynamic study of the angular momentum transfer from the glueball to the plasma by considering string orbits around rotating AdS black holes. We find that standard expectations, such as the complete thermal dissociation of the glueball, are borne out after subtle properties of rotating AdS black holes are taken into account.

  13. 27 CFR 19.456 - Adding denaturants.

    Science.gov (United States)

    2010-04-01

    ... Denaturation § 19.456 Adding denaturants. Denaturants and spirits shall be mixed in packages, tanks, or bulk... methods of mixing denaturants and spirits if he deems such denaturation will not hinder effective...

  14. The contribution of technology to added value

    CERN Document Server

    Fernandes, António S C

    2013-01-01

    There is a wide consensus that introduction of technology to the production process contributes to an overall economic value, however, confusion between technology, knowledge and capital often makes value calculations ambiguous and non-objective. The Contribution of Technology to Added Value addresses not only this issue of definition but also provides a production model to assess the value contribution of technology within the production process. A clarification  of fundamental semantics  provides a significant taxonomy for technology dependence, and allows understanding and modeling of how knowledge, technology and capital individually contribute to production and to value adding. A new technology dependence taxonomy is proposed and assessed following chapters explaining growth models, the KTC model and technology index values. Balancing theoretical knowledge with real-world data and applications The Contribution of Technology to Added Value clarifies the issue of value adding for a range of different vie...

  15. Hypoglycaemia when adding sulphonylurea to metformin

    DEFF Research Database (Denmark)

    Andersen, Stig Ejdrup; Christensen, Mikkel

    2016-01-01

    when added to metformin. METHODS: A systematic review identified RCTs lasting 12-52 weeks and evaluating SUs added to inadequate metformin monotherapy (≥1000 mg/day) in type 2 diabetes. Adding RCTs investigating the active comparators from the identified SU trials, we established a coherent network...... of hypoglycaemia was lowest with gliclazide compared to glipizide (OR 0.22, CrI: 0.05 to 0.96), glimepiride (OR 0.40, CrI: 0.13 to 1.27), and glibenclamide (OR 0.21, CrI: 0.03 to 1.48). A major limitation is varying definitions of hypoglycaemia across studies. CONCLUSIONS: When added to metformin, gliclazide...

  16. An Alternative Path to the Boundary - the CFT as the Fourier Space of AdS

    OpenAIRE

    Tolfree, Ian M.

    2008-01-01

    In this paper we shed new light on the AdS/CFT duality by interpreting the CFT as the Fourier space of AdS. We make use of well known integral geometry techniques to derive the Fourier transformation of a function defined on the AdS hyperboloid. We show that the Fourier Transformation of a function on the hyperboloid is a function defined on the boundary. We find that the Green's functions from the literature are actually the Fourier weights (i.e. plane wave solutions) of the transformation a...

  17. The Tetrahedral Zamolodchikov Algebra and the {AdS_5× S^5} S-matrix

    Science.gov (United States)

    Mitev, Vladimir; Staudacher, Matthias; Tsuboi, Zengo

    2017-08-01

    The S-matrix of the {AdS_5× S^5} string theory is a tensor product of two centrally extended su{(2|2)\\ltimes R^2 S-matrices, each of which is related to the R-matrix of the Hubbard model. The R-matrix of the Hubbard model was first found by Shastry, who ingeniously exploited the fact that, for zero coupling, the Hubbard model can be decomposed into two XX models. In this article, we review and clarify this construction from the AdS/CFT perspective and investigate the implications this has for the {AdS_5× S^5} S-matrix.

  18. Countering A2/AD with Swarming

    Science.gov (United States)

    2016-04-01

    inferior force can deny or delay a decisive engagement through time or attrition ultimately changing the political calculus.6 Using chess as an...deterrence in a non-nuclear scenario. Conventional deterrence is largely based on perceptions . Creating the wrong perception can cause conventional...necessarily defeat an enemy’s A2/AD strategy. Rather, the swarm needs to only create a perception that the U.S. is willing to fight within the A2/AD

  19. Mobile Offloading in Wireless Ad Hoc Networks

    OpenAIRE

    Kalejaiye, Gabriel B. T.; Rondina, João A. S. R.; Albuquerque, Leonardo V. V. L.; Pereira, Taís L.; Campos, Luiz F. O.; Melo, Raphael A. S.; Mascarenhas, Daniel S.; Carvalho, Marcelo M.

    2014-01-01

    This paper describes a strategy that was designed, implemented, and presented at the {\\it Mobile Ad Hoc Networking Interoperability and Cooperation (MANIAC) Challenge 2013}. The theme of the MANIAC Challenge 2013 was ``Mobile Data Offloading,'' and consisted on developing and comparatively evaluating strategies to offload infrastructure access points via customer ad hoc forwarding using handheld devices (e.g., tablets and smartphones). According to the challenge rules, a hop-by-hop bidding co...

  20. New Features in the ADS Abstract Service

    Science.gov (United States)

    Eichhorn, G.; Accomazzi, A.; Grant, C. S.; Henneken, E.; Kurtz, M. J.; Murray, S. S.

    2004-12-01

    The ADS now provides a search system for close to 4 million records. The data are organized in 4 databases, Astronomy/Planetary Sciences, Physics/Geophysics, Instrumentation, and ArXiv Preprints. The ADS is a NASA funded project and is free to use for everybody world-wide. We have recently extracted a large number of references from article reference lists. We now have over 16 million citing/cited reference pairs. This provides a very comprehensive citation database. During the last year we implemented a full text search system. This allows you to search the full text of all journals that we have scanned. This provides a unique way to find information, especially from the older literature. We recently implemented a customized notification service, called myADS. This service lets you specify several queries that are executed against new entries in the database whenever the database is updated. It also informs about new citations to your articles and new preprints, as well as what other articles are of interest to the users of the ADS. The ADS can be accessed at http://ads.harvard.edu

  1. Gauge symmetries and holographic anomalies of Chern-Simons and transgression AdS gravity

    Energy Technology Data Exchange (ETDEWEB)

    Mora, Pablo [Centro Universitario Regional Este (CURE), Universidad de la República, Uruguay,Ruta 9 Km 207, Rocha (Uruguay)

    2015-04-20

    We review the issue of gauge and gravitational anomalies with backgrounds, offering a new outlook on some aspects of these questions. We compute the holographic anomalies of hypothetical theories dual, in the sense of the AdS-CFT correspondence, to Chern-Simons AdS gravity. Those anomalies are either gauge anomalies, associated to the AdS gauge group of the theory, or diffeomorphism anomalies, with each kind related to the other. AdS gauge anomalies include Weyl, Lorentz (gravitational) and gauge translations while diffeomorphism anomalies include gravitational and Weyl (or scale) anomalies. Our results therefore go beyond previous investigations on Chern-Simons AdS gravity holograpic anomalies, that dealt only with Weyl anomalies. Furthermore, our calculations were done allowing a non vanishing torsion, unlike previous works that considered only the zero torsion, or metric, case. As a result of using suitable action principles for Chern-Simons AdS gravity, coming from Transgression forms, we obtain finite results without the need for further regularization. Our results are of potential interest for Lovelock gravity theories, as it has been shown that the boundary terms dictated by the transgressions for Chern-Simons gravity are also suitable to regularize Lovelock theories. The Wess-Zumino consistency condition ensures that anomalies of the generic form computed here should appear for these and other theories.

  2. Supersymmetric AdS_2× Σ _2 solutions from tri-sasakian truncation

    Science.gov (United States)

    Karndumri, Parinya

    2017-10-01

    A class of AdS_2× Σ _2, with Σ _2 being a two-sphere or a hyperbolic space, solutions within four-dimensional N=4 gauged supergravity coupled to three-vector multiplets with dyonic gauging is identified. The gauged supergravity has a non-semisimple SO(3)\\ltimes (T^3,\\hat{T}^3) gauge group and can be obtained from a consistent truncation of 11-dimensional supergravity on a tri-sasakian manifold. The maximally symmetric vacua contain AdS_4 geometries with N=1,3 supersymmetry corresponding to N=1 and N=3 superconformal field theories (SCFTs) in three dimensions. We find supersymmetric solutions of the form AdS_2× Σ _2 preserving two supercharges. These solutions describe twisted compactifications of the dual N=1 and N=3 SCFTs and should arise as near horizon geometries of dyonic black holes in asymptotically AdS_4 space-time. Most solutions have hyperbolic horizons although some of them exhibit spherical horizons. These provide a new class of AdS_2× Σ _2 geometries with known M-theory origin.

  3. AdS/CFT duality user guide

    CERN Document Server

    Natsuume, Makoto

    2015-01-01

    This book describes applications of the AdS/CFT duality to the "real world." The AdS/CFT duality is an idea that originated from string theory and is a powerful tool for analyzing strongly-coupled gauge theories using classical gravitational theories. In recent years, it has been shown that one prediction of AdS/CFT is indeed close to the experimental result of the real quark–gluon plasma. Since then, the AdS/CFT duality has been applied to various fields of physics; examples are QCD, nuclear physics, condensed-matter physics, and nonequilibrium physics.   The aim of this book is to provide background materials such as string theory, black holes, nuclear physics, condensed-matter physics, and nonequilibrium physics as well as key applications of the AdS/CFT duality in a single volume. The emphasis throughout the book is on a pedagogical and intuitive approach focusing on the underlying physical concepts. It also includes step-by-step computations for important results, which are useful for beginners.   Th...

  4. Non-spherical collapse in AdS and early thermalization in RHIC

    Science.gov (United States)

    Oh, Eunseok; Sin, Sang-Jin

    2013-10-01

    In the flat space, non-spherical shells collapse to give globular cluster after many oscillations. We show that in anti de Sitter space, they form black holes in one dynamical time. We propose that this is the mechanism of early thermalization in strong quark-gluon plasma in gravity dual. This is traced back to the a remarkable property of AdS: the period in radial motion is amplitude independent in spite of the non-linearity of the equation of motion. We investigate the interaction effect numerically and observe the same qualitative behavior for the attractive forces. For repulsive interactions, particles halt at a small but finite radius for long time due to the specific structure of the bulk AdS propagator. It helps hair creation in the AdS black hole.

  5. Thermal stability analysis of nonlinearly charged asymptotic AdS black hole solutions

    Science.gov (United States)

    Dehghani, M.; Hamidi, S. F.

    2017-08-01

    In this paper, the four-dimensional nonlinearly charged black hole solutions have been considered in the presence of the power Maxwell invariant electrodynamics. Two new classes of anti-de Sitter (AdS) black hole solutions have been introduced according to different amounts of the parameters in the nonlinear theory of electrodynamics. The conserved and thermodynamical quantities of either of the black hole classes have been calculated from geometrical and thermodynamical approaches, separately. It has been shown that the first law of black hole thermodynamics is satisfied for either of the AdS black hole solutions we just obtained. Through the canonical and grand canonical ensemble methods, the black hole thermal stability or phase transitions have been analyzed by considering the heat capacities with the fixed black hole charge and fixed electric potential, respectively. It has been found that the new AdS black holes are stable if some simple conditions are satisfied.

  6. On thermodynamics of AdS black holes in M-theory

    Energy Technology Data Exchange (ETDEWEB)

    Belhaj, A. [Universite Sultan Moulay Slimane, Departement de Physique, LIRST, Faculte Polydisciplinaire, Beni Mellal (Morocco); Cadi Ayyad University, High Energy Physics and Astrophysics Laboratory, FSSM, Marrakesh (Morocco); Chabab, M.; Masmar, K. [Cadi Ayyad University, High Energy Physics and Astrophysics Laboratory, FSSM, Marrakesh (Morocco); El Moumni, H. [Cadi Ayyad University, High Energy Physics and Astrophysics Laboratory, FSSM, Marrakesh (Morocco); Universite Ibn Zohr, Departement de Physique, Faculte des Sciences, Agadir (Morocco); Sedra, M.B. [Universite Ibn Tofail, Departement de Physique, LASIMO, Faculte des Sciences, Kenitra (Morocco)

    2016-02-15

    Motivated by recent work on asymptotically AdS{sub 4} black holes in M-theory, we investigate the thermodynamics and thermodynamical geometry of AdS black holes from M2- and M5-branes. Concretely, we consider AdS black holes in AdS{sub p+2} x S{sup 11-p-2}, where p = 2,5 by interpreting the number of M2- (and M5-branes) as a thermodynamical variable. More precisely, we study the corresponding phase transition to examine their stabilities by calculating and discussing various thermodynamical quantities including the chemical potential. Then we compute the thermodynamical curvatures from the Quevedo metric for M2- and M5-branes geometries to reconsider the stability of such black holes. The Quevedo metric singularities recover similar stability results provided by the phase-transition program. It has been shown that similar behaviors are also present in the limit of large N. (orig.)

  7. Spinning strings in AdS3×S3 with NS–NS flux

    Directory of Open Access Journals (Sweden)

    Rafael Hernández

    2014-11-01

    Full Text Available The sigma model describing closed strings rotating in AdS3×S3 is known to reduce to the one-dimensional Neumann–Rosochatius integrable system. In this article we show that closed spinning strings in AdS3×S3×T4 in the presence of NS–NS three-form flux can be described by an extension of the Neumann–Rosochatius system. We consider closed strings rotating with one spin in AdS3 and two different angular momenta in S3. For a class of solutions with constant radii we find the dependence of the classical energy on the spin and the angular momenta as an expansion in the square of the 't Hooft coupling of the theory.

  8. QCD Condensates and Holographic Wilson Loops for Asymptotically AdS Spaces

    Energy Technology Data Exchange (ETDEWEB)

    Quevedo, R. Carcasses [Instituto Balseiro, Centro Atomico Bariloche, 8400 San Carlos de Bariloche (Argentina); CONICET, Rivadavia 1917, 1033 Buenos Aires (Argentina); Goity, Jose L. [Hampton University, Hampton, VA 23668 (United States); Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Trinchero, Roberto C. [Instituto Balseiro, Centro Atomico Bariloche, 8400 San Carlos de Bariloche (Argentina); CONICET, Rivadavia 1917, 1033 Buenos Aires (Argentina)

    2014-02-01

    The minimization of the Nambu-Goto (NG) action for a surface whose contour defines a circular Wilson loop of radius a placed at a finite value of the coordinate orthogonal to the border is considered. This is done for asymptotically AdS spaces. The condensates of dimension n = 2, 4, 6, 8, and 10 are calculated in terms of the coefficients in the expansion in powers of the radius a of the on-shell subtracted NG action for small a->0. The subtraction employed is such that it presents no conflict with conformal invariance in the AdS case and need not introduce an additional infrared scale for the case of confining geometries. It is shown that the UV value of the gluon condensates is universal in the sense that it only depends on the first coefficients of the difference with the AdS case.

  9. Extended Hamiltonian action for arbitrary spin fields in flat and AdS space

    Science.gov (United States)

    Metsaev, R. R.

    2013-05-01

    Totally symmetric, arbitrary spin massless and massive free fields in flat and AdS space and conformal fields in flat space are studied. An extended gauge-invariant Hamiltonian action for such fields is obtained. The action is constructed out of phase space fields and Lagrangian multipliers which are free of algebraic constraints. Gauge transformations of the phase space fields and Lagrangian multipliers are derived. Use of the Poincaré parametrization of AdS space allows us to treat fields in flat space and AdS space on an equal footing. This article is part of a special issue of Journal of Physics A: Mathematical and Theoretical devoted to ‘Higher spin theories and holography’.

  10. Introduction to AdS/CFT correspondence

    CERN Document Server

    Nastase, Horatiu

    2015-01-01

    Providing a pedagogical introduction to the rapidly developing field of AdS/CFT correspondence, this is one of the first texts to provide an accessible introduction to all the necessary concepts needed to engage with the methods, tools and applications of AdS/CFT. Without assuming anything beyond an introductory course in quantum field theory, it begins by guiding the reader through the basic concepts of field theory and gauge theory, general relativity, supersymmetry, supergravity, string theory and conformal field theory, before moving on to give a clear and rigorous account of AdS/CFT correspondence. The final section discusses the more specialised applications, including QCD, quark-gluon plasma and condensed matter. This book is self-contained and learner-focused, featuring numerous exercises and examples. It is essential reading for both students and researchers across the fields of particle, nuclear and condensed matter physics.

  11. Value added meat marketing around the globe

    DEFF Research Database (Denmark)

    Grebitus, Carola; Mueller Loose, Simone

    In highly competitive meat markets it is important to offer value added products to consumers. Thus, we need to understand which attributes are especially valued by consumers. This track session will contribute to a better understanding of consumer preferences for value added meats across different...... countries and simultaneously address different stages of the food chain by acknowledging factors such as breeding, forage (fat content), meat cuts as well as product labelling and packaging. Comparing consumers’ choices for value added pork and beef across different countries is the main theme and focus...... practices will be examined and the economic and technological dimensions of meat packaging will be related to each other presenting work from the US and Germany. Lastly, we will uncover the competitive nature between different beef cuts for Italian consumers....

  12. Pengukuran Kinerja Keuangan dengan Pendekatan Egonomic Value Added dan Financial Value Added

    OpenAIRE

    Felisia

    2011-01-01

    Performance measurement has become an important indicator not only for companies but also for investors. It indicates the capability of companies in managing their capital. Performance measurement can be divided into financial and non-financial performance measurement. This article will discuss further about financial performance measurement using Economic Value Added (EVA) and Financial Value Added (FVA) Economic Value Added was developed by Stern, Stewart & Company, while Financial Value...

  13. Alternative path to the boundary: The CFT as the Fourier transform in AdS space

    Science.gov (United States)

    Tolfree, Ian M.

    2008-11-01

    In this paper we shed new light on the AdS/CFT duality by interpreting the CFT as the Fourier transform in AdS space. We make use of well-known integral geometry techniques to derive the Fourier transformation of a function defined on the AdS hyperboloid. We show that the Fourier transformation of a function on the hyperboloid is a function defined on the boundary. We find that the Green’s functions from the literature are actually the Fourier weights (i.e. plane wave solutions) of the transformation and that the boundary values of fields appearing in the correspondence are the Fourier components of the transformation. One is thus left to interpret the CFT as the quantized version of a classical theory in AdS and the dual operator as the Fourier coefficients. Group theoretic considerations are discussed in relation to the transformation and its potential use in constructing QCD-like theories. In addition, we consider possible implications involving understanding the dual of AdS black holes.

  14. iAd Production Beginner's Guide

    CERN Document Server

    Collier, Ben

    2012-01-01

    This beginner's guide focuses on getting you through all the major learning points in a smooth, logical order. You'll also see how to avoid some common pitfalls. This book is for brands, advertisers and developers who want to create compelling, emotive, iAd advertisements that generate revenue and increase brand awareness. You don't need previous experience of creating adverts or apps for iPhone and iPad, as you'll be taken through the entire process to make motion-rich, beautiful ads.

  15. Ad hoc networks telecommunications and game theory

    CERN Document Server

    Benslama, Malek; Batatia, Hadj

    2015-01-01

    Random SALOHA and CSMA protocols that are used to access MAC in ad hoc networks are very small compared to the multiple and spontaneous use of the transmission channel. So they have low immunity to the problems of packet collisions. Indeed, the transmission time is the critical factor in the operation of such networks. The simulations demonstrate the positive impact of erasure codes on the throughput of the transmission in ad hoc networks. However, the network still suffers from the intermittency and volatility of its efficiency throughout its operation, and it switches quickly to the satura

  16. Tribunales arbitrales ad hoc en el Mercosur

    OpenAIRE

    Bou Franch, Valentín

    2011-01-01

    El Mercosur tiene establecido un procedimiento obligatorio de solución de controversias comerciales entre sus Estados miembros. No obstante, en caso de surgir una controversia, el Estado demandante y el demandado pueden pactar de mutuo acuerdo que la misma no se someta al procedimiento ordinario de solución, sino a un Tribunal arbitral ad hoc. En este trabajo, se analiza la elaboración de las dos listas de árbitros, la constitución de cada Tribunal arbitral ad hoc, el procedimiento y la oblig...

  17. Adding value to corporate ventures through governance

    DEFF Research Database (Denmark)

    Skat-Rørdam, Peter

    2005-01-01

    This working paper examines the governance of corporate ventures based upon a qualitative interview based case study of a European industrial conglomerate. The purpose is to explore the value adding mechanisms of governance, that are considered more critical to the success of corporate ventures...... than the control mechanisms widely explored in connection with the governance of large public corporations. The paper provides examples of how value can be added as well as perspectives on the challenges and effectivenes here-off as evaluated by venture CEO's and venture board members...

  18. Vehicular ad hoc network security and privacy

    CERN Document Server

    Lin, X

    2015-01-01

    Unlike any other book in this area, this book provides innovative solutions to security issues, making this book a must read for anyone working with or studying security measures. Vehicular Ad Hoc Network Security and Privacy mainly focuses on security and privacy issues related to vehicular communication systems. It begins with a comprehensive introduction to vehicular ad hoc network and its unique security threats and privacy concerns and then illustrates how to address those challenges in highly dynamic and large size wireless network environments from multiple perspectives. This book is richly illustrated with detailed designs and results for approaching security and privacy threats.

  19. QCD condensates in ADS/QCD

    DEFF Research Database (Denmark)

    Bechi, Jacopo

    2009-01-01

    This paper focuses on some issues about condensates and renormalization in AdS/QCD models. In particular we consider the consistency of the AdS/QCD approach for scale dependent quantities as the chiral condensate questioned in some recent papers and the 4D meaning of the 5D cosmological constant...... in a model in which the QCD is dual to a 5D gravity theory. We will be able to give some arguments that the cosmological constant is related to the QCD gluon condensate....

  20. ENEA presenta sistema ADS per trattamento scorie

    CERN Multimedia

    2002-01-01

    "Arriva il sistema Ads (Accelerator driven system) per il trattamento dei rifiuti radioattivi. Lo studio di fattibilita' per l' innovativa tecnologia, realizzato da un gruppo di lavoro congiunto Enea, Cea, Cern e Ansaldo, e' stato presentato oggi nel corso di un workshop presieduto dal premio Nobel per la fisica, Carlo Rubbia" (1/2 page).

  1. Added value: The differences that count

    Directory of Open Access Journals (Sweden)

    Dominique Bouchet

    2012-08-01

    Full Text Available Clinging to a simplistic conceptualization of the concept of added value might impair our capability to develop insights to what really matters today when companies seek to make differences within the global market. Today it is more necessary than ever to take into account the importance of language and culture as competitive factors.

  2. Accelerator development in India for ADS programme

    Indian Academy of Sciences (India)

    LEHIPA), as front-end injector of the 1 GeV accelerator for the ADS programme, has been initiated. The major components of LEHIPA (20 MeV, 30 mA) are a 50 keV ECR ion source, a 3 MeV Radio Frequency Quadrupole (RFQ) and a 20 MeV drift ...

  3. "Value Added" Gauge of Teaching Probed

    Science.gov (United States)

    Viadero, Debra

    2009-01-01

    A new study by a public and labor economist suggests that "value added" methods for determining the effectiveness of classroom teachers are built on some shaky assumptions and may be misleading. The study, due to be published in February in the "Quarterly Journal of Economics," is the first of a handful of papers now in the…

  4. CERN Enters the Second Year AD

    CERN Multimedia

    2001-01-01

    2001 is the year that physics at CERN's new Antiproton Decelerator (AD) really gets up to speed. Changes to the AD since 2000 mean that this year the three experiments, ASACUSA, ATHENA, and ATRAP have had more intense antiproton beams to work with since physics started on 7 May. CERN's Antiproton Decelerator - major improvements for 2001. The AD is a unique machine. Its job is to decelerate not accelerate particle beams, and it has to handle beam energies that vary by an unprecedented factor of 35 from injection to ejection. Since the machine was designed to operate at fixed energy in its first incarnation as a collector of antiprotons for CERN's 1980s proton antiproton collider, this factor of 35 presented a big challenge to the AD team. The team's design goal was to hang onto a quarter of the injected antiprotons through their vertiginous fall in energy, and to repeat the deceleration cycle once per minute. Improvements to the machine over the winter shutdown and through the first four weeks of 2001 run...

  5. Adding Test Generation to the Teaching Machine

    Science.gov (United States)

    Bruce-Lockhart, Michael; Norvell, Theodore; Crescenzi, Pierluigi

    2009-01-01

    We propose an extension of the Teaching Machine project, called Quiz Generator, that allows instructors to produce assessment quizzes in the field of algorithm and data structures quite easily. This extension makes use of visualization techniques and is based on new features of the Teaching Machine that allow third-party visualizers to be added as…

  6. Ad-Hoc Transient Communities Simulation

    NARCIS (Netherlands)

    Van den Berg, Bert; Van Rosmalen, Peter; Sloep, Peter; Brouns, Francis; Fetter, Sibren; Berlanga, Adriana

    2009-01-01

    Van den Berg, B., Van Rosmalen, P., Sloep, P. B., Brouns, F., Fetter, S., & Berlanga, A. J. (2009). Ad-Hoc Transient Communities Simulation. The Netlogo application is distributed as a java applet and for that matter part of an archive which contains also the NetlogoLiteJar and the index.htm to

  7. Adding calcium improves lithium ferrite core

    Science.gov (United States)

    Lessoff, H.

    1969-01-01

    Adding calcium increases uniformity of grain growth over a wide range of sintering temperatures and reduces porosity within the grain. Ferrite cores containing calcium have square hysteresis loops and high curie temperatures, making them useful in coincident current memories of digital electronic computers.

  8. The foresight of AD de Groot

    NARCIS (Netherlands)

    Jansen, E. P. W. A.; Nieuwenhuis, A. F. M.

    2013-01-01

    Study success rates in higher education were already described in an article in Pedagogische Studien in 1959. Professor A.D. de Groot, internationally well-known by his research on Thought and choice in chess, analysed the success rate figures provided by Statistics Netherlands. Based on the

  9. Epidemiological studies on cutaneous leishmaniasis in Ad ...

    African Journals Online (AJOL)

    Dawadimi region of Saudi Arabia. Methods: Data from the patients included in this retrospective study were collected from the Leishmaniasis Control Center of Ad-Dawadimi District of Saudi Arabia. A total of 370 patients with CL were recorded from ...

  10. Anomaly Detection Techniques for Ad Hoc Networks

    Science.gov (United States)

    Cai, Chaoli

    2009-01-01

    Anomaly detection is an important and indispensable aspect of any computer security mechanism. Ad hoc and mobile networks consist of a number of peer mobile nodes that are capable of communicating with each other absent a fixed infrastructure. Arbitrary node movements and lack of centralized control make them vulnerable to a wide variety of…

  11. Value-Added Analysis in Instruction

    Science.gov (United States)

    Nicholson, Michael R.; Brown, Jeffrey R.

    2010-01-01

    Value-added data provide a viable alternative for gauging school effectiveness--one virtually free of the confounding effects of student demographics and other factors relating to student learning. How is it different from other measuring methods? It concentrates on growth, rather than attainment. This strengthens the concept and measurement of…

  12. Value Added School Review Field Guide

    Science.gov (United States)

    Alberta Education, 2009

    2009-01-01

    The "Value-Added School Review (VSR)" is an analytical model designed to assist schools in identifying and addressing opportunities for school improvement. The model works best when it is focused purposefully on students and the student learning outcomes as defined in the "Guide to Education". It complements the processes…

  13. Value-Added Modeling in Physical Education

    Science.gov (United States)

    Hushman, Glenn; Hushman, Carolyn

    2015-01-01

    The educational reform movement in the United States has resulted in a variety of states moving toward a system of value-added modeling (VAM) to measure a teacher's contribution to student achievement. Recently, many states have begun using VAM scores as part of a larger system to evaluate teacher performance. In the past decade, only "core…

  14. DAWN: Dynamic Ad-hoc Wireless Network

    Science.gov (United States)

    2016-06-19

    Wireless Network 1 Introduction The network-centric battlefield includes sensors, troop carriers, unmanned air vehicle (UAV), aircraft, smart ...Bellman Control Heritage Award. • Honorary Doctorate at Technical University of Crete. • Best paper award at 2008 IEEE International Conference on Mobile Ad-hoc and Sensor Systems.

  15. Ad-Coop Positioning System (ACPS)

    DEFF Research Database (Denmark)

    Frattasi, Simone; Monti, Marco

    2008-01-01

    -hoc connections among pairs of mobiles. Specifically, peer-to-peer (P2P) communications are exploited in a mesh fashion within cellular-established clusters for cooperation-aided localization purposes (from that, the word ad-coop is derived). The major contribution of this work is the design of the data fusion...

  16. Swift Trust in Distributed Ad Hoc Teams

    Science.gov (United States)

    2007-10-04

    not visible or likely to be in close proximity . Page 22 Swift Trust in Distributed Ad hoc Teams Humansystems® mission ended, the servers were...simply allow less “ poetic license” when making judgements about other people. Perhaps asking about a more ambiguous behaviour or task would have yielded

  17. An alternative perspective to observe the critical phenomena of dilaton AdS black holes

    CERN Document Server

    Mo, Jie-Xiong

    2016-01-01

    The critical phenomena of dilaton AdS black holes are probed from a totally different perspective other than the $P-v$ criticality and the $q-U$ criticality discussed in the former literature. We investigate not only the two point correlation function but also the entanglement entropy of dilaton AdS black holes. We achieve this goal by solving the equation of motion constrained by the boundary condition numerically and we concentrate on $\\delta L$ and $\\delta S$ which have been regularized by subtracting the terms in pure AdS with the same boundary region. For both the two point correlation function and the entanglement entropy, we consider $4\\times2\\times2=16$ cases due to different choices of parameters. The van der Waals like behavior can be clearly witnessed from all the $T-\\delta L$ ($T-\\delta S$) graphs for $qAdS black holes are disclosed. Furthermore, we discuss the stability of dilaton...

  18. Value Added to What? How a Ceiling in the Testing Instrument Influences Value-Added Estimation

    Science.gov (United States)

    Koedel, Cory; Betts, Julian

    2010-01-01

    Value-added measures of teacher quality may be sensitive to the quantitative properties of the student tests upon which they are based. This article focuses on the sensitivity of value added to test score ceiling effects. Test score ceilings are increasingly common in testing instruments across the country as education policy continues to…

  19. Integrability of the AdS_5 x S^5 superstring and its deformations

    NARCIS (Netherlands)

    van Tongeren, S.J.

    2013-01-01

    Based on the author's PhD thesis, this article reviews the application of integrability to the spectral problem of strings on AdS_5 x S^5 and its deformations. We begin with a pedagogical introduction to integrable field theories culminating in the description of their finite-volume spectra through

  20. On Critical Massive (Super)Gravity in adS(3)

    NARCIS (Netherlands)

    Bergshoeff, Eric A.; Hohm, Olaf; Rosseel, Jan; Sezgin, Ergin; Townsend, Paul K.; Aldaya,; Barcelo, C; Jaramillo, JL

    2011-01-01

    We review the status of three-dimensional "general massive gravity" (GMG) in its linearization about an anti-de Sitter (adS) vacuum, focusing on critical points in parameter space that yield generalizations of "chiral gravity". We then show how these results extend to,N = 1 super-GMG, expanded about

  1. The differential effects of position, ad and reader characteristics on readers' processing of newspaper ads

    NARCIS (Netherlands)

    Smit, E.G.; Neijens, P.C.; Heath, R.

    2013-01-01

    Building on previous research on the processing of newspaper ads, this comprehensive field study, with 26,556 newspaper readers and 290 unique advertisements, investigated the combined effects of position in the newspaper, ad characteristics and reader characteristics. The results show a

  2. Near horizon data and physical charges of extremal AdS black holes

    NARCIS (Netherlands)

    Astefanesei, D.; Banerjee, N.; Dutta, S.

    2011-01-01

    We compute the physical charges and discuss the properties of a large class of five-dimensional extremal AdS black holes by using the near horizon data. Our examples include baryonic and electromagnetic black branes, as well as supersymmetric spinning black holes. In the presence of the gauge

  3. Multi-Skyrmions on AdS2 × S2, rational maps and popcorn transitions

    Science.gov (United States)

    Canfora, Fabrizio; Tallarita, Gianni

    2017-08-01

    By combining two different techniques to construct multi-soliton solutions of the (3 + 1)-dimensional Skyrme model, the generalized hedgehog and the rational map ansatz, we find multi-Skyrmion configurations in AdS2 ×S2. We construct Skyrmionic multi-layered configurations such that the total Baryon charge is the product of the number of kinks along the radial AdS2 direction and the degree of the rational map. We show that, for fixed total Baryon charge, as one increases the charge density on ∂ (AdS2 ×S2) , it becomes increasingly convenient energetically to have configurations with more peaks in the radial AdS2 direction but a lower degree of the rational map. This has a direct relation with the so-called holographic popcorn transitions in which, when the charge density is high, multi-layered configurations with low charge on each layer are favored over configurations with few layers but with higher charge on each layer. The case in which the geometry is M2 ×S2 can also be analyzed.

  4. Avoiding Ad Avoidance: Factors Affecting the Perception of Online Banner Ads

    Science.gov (United States)

    Portnoy, Felix

    2012-01-01

    This dissertation examined the effect of search type, ad saliency, and ad repetition on the perception of online banner advertisements. In the first study, 48 student participants conducted simulated search tasks using mixed factorial design where search type (known-item vs. exploratory) was manipulated within-subject and the banner saliency level…

  5. Geometry and supersymmetry of heterotic warped flux AdS backgrounds

    Science.gov (United States)

    Beck, S.; Gutowski, J.; Papadopoulos, G.

    2015-07-01

    We classify the geometries of the most general warped, flux AdS backgrounds of heterotic supergravity up to two loop order in sigma model perturbation theory. We show under some mild assumptions that there are no AdS n backgrounds with n ≠ 3. Moreover the warp factor of AdS3 backgrounds is constant, the geometry is a product AdS 3 × M 7 and such solutions preserve, 2, 4, 6 and 8 supersymmetries. The geometry of M 7 has been specified in all cases. For 2 supersymmetries, it has been found that M 7 admits a suitably restricted G 2 structure. For 4 supersymmetries, M 7 has an SU(3) structure and can be described locally as a circle fibration over a 6-dimensional KT manifold. For 6 and 8 supersymmetries, M 7 has an SU(2) structure and can be described locally as a S 3 fibration over a 4-dimensional manifold which either has an anti-self dual Weyl tensor or a hyper-Kähler structure, respectively. We also demonstrate a new Lichnerowicz type theorem in the presence of α' corrections.

  6. The complete AdS_3 x S^3 x T^4 worldsheet S-matrix

    NARCIS (Netherlands)

    Borsato, Riccardo|info:eu-repo/dai/nl/370952170; Sax, Olof Ohlsson; Sfondrini, Alessandro|info:eu-repo/dai/nl/330983083; jr, Bogdan Stefanski

    2014-01-01

    We derive the non-perturbative worldsheet S matrix for fundamental excitations of Type IIB superstring theory on AdS_3 x S^3 x T^4 with Ramond-Ramond flux. To this end, we study the off-shell symmetry algebra of the theory and its representations. We use these to determine the S matrix up to scalar

  7. The bound state S-matrix for AdS5×S5 superstring

    NARCIS (Netherlands)

    Arutyunov, G.E.; de Leeuw, M.; Torrielli, A.

    2009-01-01

    We determine the S-matrix that describes scattering of arbitrary bound states in the light-cone string theory in AdS5×S5. The corresponding construction relies on the Yangian symmetry and the superspace formalism for the bound state representations. The basic analytic structure supporting the

  8. S-matrix for strings on η-deformed AdS5 x S5

    NARCIS (Netherlands)

    Arutyunov, Gleb; Borsato, Riccardo; Frolov, Sergey

    2013-01-01

    We determine the bosonic part of the superstring sigma model Lagrangian on η-deformed AdS5 × S5, and use it to compute the perturbative world-sheet scattering matrix of bosonic particles of the model. We then compare it with the large string tension limit of the q-deformed S-matrix and find exact

  9. The S-matrix of the AdS5xS5 superstring

    NARCIS (Netherlands)

    de Leeuw, M.

    2010-01-01

    According to the gauge-string duality conjecture, the spectrum of scaling dimensions of composite gauge invariant operators of the planar maximally supersymmetric Yang-Mills theory in four dimensions should be equivalent to the energy spectrum of superstrings propagating in the AdS5 x S5 space-time,

  10. S-matrix for strings on η-deformed AdS5 x S5

    NARCIS (Netherlands)

    Arutyunov, G.E.|info:eu-repo/dai/nl/326372822; Borsato, R.|info:eu-repo/dai/nl/370952170; Frolov, S.

    2013-01-01

    We determine the bosonic part of the superstring sigma model Lagrangian on η-deformed AdS5 x S5, and use it to compute the perturbative world-sheet scattering matrix of bosonic particles of the model. We then compare it with the large string tension limit of the q-deformed S-matrix and find exact

  11. Characterization of cells transformed by Ad5/Ad12 hybrid early region I plasmids

    NARCIS (Netherlands)

    Bernards, R.A.; Houweling, A.; Schrier, P.I.; Bos, J.L.; Eb, A.J. van der

    1982-01-01

    Early region I (EI) of the human adenoviruses consists of two transcriptional units, EIa and EIb. We have constructed plasmids containing hybrid EI regions from the nononcogenic adenovirus type 5 (Ad5) and the highly oncogenic Ad12. Each plasmid essentially contains the EIa region of one serotype

  12. Covariant anomalies and Hawking radiation from Kaluza–Klein AdS ...

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 80; Issue 2. Covariant anomalies and Hawking radiation from Kaluza–Klein AdS ... angular momentum and energy momentum tensor are derived here. Our results support the common view that Hawking radiation is the quantum effect arising at the event horizon.

  13. Black hole formation in AdS Einstein-Gauss-Bonnet gravity

    Science.gov (United States)

    Deppe, Nils; Kolly, Allison; Frey, Andrew R.; Kunstatter, Gabor

    2016-10-01

    AdS spacetime has been shown numerically to be unstable against a large class of arbitrarily small perturbations. In [1], the authors presented a preliminary study of the effects on stability of changing the local dynamics by adding a Gauss-Bonnet term to the Einstein action. Here we provide further details as well as new results with improved numerical methods. In particular, we elucidate new structure in Choptuik scaling plots. We also provide evidence of chaotic behavior at the transition between immediate horizon formation and horizon formation after the matter pulse reflects from the AdS conformal boundary. Finally, we present data suggesting the formation of naked singularities in spacetimes with ADM mass below the algebraic bound for black hole formation.

  14. Black hole formation in AdS Einstein-Gauss-Bonnet gravity

    Energy Technology Data Exchange (ETDEWEB)

    Deppe, Nils [Cornell Center for Astrophysics and Planetary Science andDepartment of Physics, Cornell University,122 Sciences Drive, Ithaca, New York 14853 (United States); Kolly, Allison [Department of Atmospheric and Oceanic Sciences, McGill University,805 Sherbrooke Street West, Montréal, Québec H3A 0B9 (Canada); Frey, Andrew R.; Kunstatter, Gabor [Department of Physics and Winnipeg Institute for Theoretical Physics, University of Winnipeg,515 Portage Avenue, Winnipeg, Manitoba R3B 2E9 (Canada)

    2016-10-17

    AdS spacetime has been shown numerically to be unstable against a large class of arbitrarily small perturbations. In http://dx.doi.org/10.1103/PhysRevLett.114.071102, the authors presented a preliminary study of the effects on stability of changing the local dynamics by adding a Gauss-Bonnet term to the Einstein action. Here we provide further details as well as new results with improved numerical methods. In particular, we elucidate new structure in Choptuik scaling plots. We also provide evidence of chaotic behavior at the transition between immediate horizon formation and horizon formation after the matter pulse reflects from the AdS conformal boundary. Finally, we present data suggesting the formation of naked singularities in spacetimes with ADM mass below the algebraic bound for black hole formation.

  15. Prevalence, proximity and predictors of alcohol ads in Central Harlem

    National Research Council Canada - National Science Library

    Kwate, Naa Oyo A; Jernigan, Meghan; Lee, Tammy

    2007-01-01

    Aims: This study examined the prevalence of alcohol ads, the spatial relationship between alcohol ads and schools, churches and playgrounds, and area-level determinants of alcohol ad density in Central Harlem, New York City. Methods...

  16. Evolutionary algorithms for mobile ad hoc networks

    CERN Document Server

    Dorronsoro, Bernabé; Danoy, Grégoire; Pigné, Yoann; Bouvry, Pascal

    2014-01-01

    Describes how evolutionary algorithms (EAs) can be used to identify, model, and minimize day-to-day problems that arise for researchers in optimization and mobile networking. Mobile ad hoc networks (MANETs), vehicular networks (VANETs), sensor networks (SNs), and hybrid networks—each of these require a designer’s keen sense and knowledge of evolutionary algorithms in order to help with the common issues that plague professionals involved in optimization and mobile networking. This book introduces readers to both mobile ad hoc networks and evolutionary algorithms, presenting basic concepts as well as detailed descriptions of each. It demonstrates how metaheuristics and evolutionary algorithms (EAs) can be used to help provide low-cost operations in the optimization process—allowing designers to put some “intelligence” or sophistication into the design. It also offers efficient and accurate information on dissemination algorithms topology management, and mobility models to address challenges in the ...

  17. Quantum load balancing in ad hoc networks

    Science.gov (United States)

    Hasanpour, M.; Shariat, S.; Barnaghi, P.; Hoseinitabatabaei, S. A.; Vahid, S.; Tafazolli, R.

    2017-06-01

    This paper presents a novel approach in targeting load balancing in ad hoc networks utilizing the properties of quantum game theory. This approach benefits from the instantaneous and information-less capability of entangled particles to synchronize the load balancing strategies in ad hoc networks. The quantum load balancing (QLB) algorithm proposed by this work is implemented on top of OLSR as the baseline routing protocol; its performance is analyzed against the baseline OLSR, and considerable gain is reported regarding some of the main QoS metrics such as delay and jitter. Furthermore, it is shown that QLB algorithm supports a solid stability gain in terms of throughput which stands a proof of concept for the load balancing properties of the proposed theory.

  18. Constrained Delaunay Triangulation for Ad Hoc Networks

    Directory of Open Access Journals (Sweden)

    D. Satyanarayana

    2008-01-01

    Full Text Available Geometric spanners can be used for efficient routing in wireless ad hoc networks. Computation of existing spanners for ad hoc networks primarily focused on geometric properties without considering network requirements. In this paper, we propose a new spanner called constrained Delaunay triangulation (CDT which considers both geometric properties and network requirements. The CDT is formed by introducing a small set of constraint edges into local Delaunay triangulation (LDel to reduce the number of hops between nodes in the network graph. We have simulated the CDT using network simulator (ns-2.28 and compared with Gabriel graph (GG, relative neighborhood graph (RNG, local Delaunay triangulation (LDel, and planarized local Delaunay triangulation (PLDel. The simulation results show that the minimum number of hops from source to destination is less than other spanners. We also observed the decrease in delay, jitter, and improvement in throughput.

  19. Supporting Dynamic Ad hoc Collaboration Capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Agarwal, Deborah A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Berket, Karlo [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2003-07-14

    Modern HENP experiments such as CMS and Atlas involve as many as 2000 collaborators around the world. Collaborations this large will be unable to meet often enough to support working closely together. Many of the tools currently available for collaboration focus on heavy-weight applications such as videoconferencing tools. While these are important, there is a more basic need for tools that support connecting physicists to work together on an ad hoc or continuous basis. Tools that support the day-to-day connectivity and underlying needs of a group of collaborators are important for providing light-weight, non-intrusive, and flexible ways to work collaboratively. Some example tools include messaging, file-sharing, and shared plot viewers. An important component of the environment is a scalable underlying communication framework. In this paper we will describe our current progress on building a dynamic and ad hoc collaboration environment and our vision for its evolution into a HENP collaboration environment.

  20. AD/HD: POSSIBLE DIAGNOSIS AND TREATMENT

    Directory of Open Access Journals (Sweden)

    Karl REICHELT

    2008-12-01

    Full Text Available The purpose of this paper is to show that a more exact diagnosis and dietary intervention in AD/HD (Attention Deficit/Hyperactivity Di­sor­der is possible and probable. The clinical symptom based diagnosis we suggest may be supplemented with physiological tests. A ge­netic and environmental inter-action is clearly involved and explainable using phenyl­ke­tonuria as a model.Method: Examining peer reviewed published papers on gut to blood, blood to brain inter­action and effect of interventions in AD/HD and our own studies in the field. The various treatment options are discussed.Results: It can be shown that a gut to brain activity is possible and probable, and dietary intervention is useful and probably safer than drugs. Preliminary data on a small five year follow up of dietary intervention is shown.

  1. Accelerator development in India for ADS programme

    Indian Academy of Sciences (India)

    Abstract. At BARC, development of a Low Energy High Intensity Proton Accelerator. (LEHIPA), as front-end injector of the 1 GeV accelerator for the ADS programme, has been initiated. The major components of LEHIPA (20 MeV, 30 mA) are a 50 keV ECR ion source, a 3 MeV Radio Frequency Quadrupole (RFQ) and a 20 ...

  2. AdS-Flows and Weyl Gravity

    CERN Document Server

    Schmidhuber, C

    2000-01-01

    An analogy is noted between RG flow equations in 4-dimensional gauge theory, as derived from the AdS/CFT correspondence, and the RG flow equations in 4-dimensional field theory coupled to a particular limit of Weyl supergravity. This suggests a possible theory of dynamical 3-branes with fluctuating 4-dimensional conformal factor. The argument involves a map from flows in 4-dimensional gauge theories to flows in a class of 2-dimensional sigma models.

  3. Drag cancellation by added-mass pumping

    CERN Document Server

    Giorgio-Serchi, F

    2016-01-01

    A submerged body subject to a sudden shape-change experiences large forces due to the variation of added-mass energy. While this phenomenon has been studied for single actuation events, application to sustained propulsion requires studying \\textit{periodic} shape-change. We do so in this work by investigating a spring-mass oscillator submerged in quiescent fluid subject to periodic changes in its volume. We develop an analytical model to investigate the relationship between added-mass variation and viscous damping and demonstrate its range of application with fully coupled fluid-solid Navier-Stokes simulations at large Stokes number. Our results demonstrate that the recovery of added-mass kinetic energy can be used to completely cancel the viscous damping of the fluid, driving the onset of sustained oscillations with amplitudes as large as four times the average body radius $r_0$. A quasi-linear relationship is found to link the terminal amplitude of the oscillations $X$, to the extent of size change $a$, wit...

  4. Transmission Strategies in MIMO Ad Hoc Networks

    Directory of Open Access Journals (Sweden)

    Fakih Khalil

    2009-01-01

    Full Text Available Abstract Precoding problem in multiple-input multiple-output (MIMO ad hoc networks is addressed in this work. Firstly, we consider the problem of maximizing the system mutual information under a power constraint. In this context, we give a brief overview of the nonlinear optimization methods, and systematically we compare their performances. Then, we propose a fast and distributed algorithm based on the quasi-Newton methods to give a lower bound of the system capacity of MIMO ad hoc networks. Our proposed algorithm solves the maximization problem while diminishing the amount of information in the feedback links needed in the cooperative optimization. Secondly, we propose a different problem formulation, which consists in minimizing the total transmit power under a quality of signal constraint. This novel problem design is motivated since the packets are captured in ad hoc networks based on their signal-to-interference-plus-noise ratio (SINR values. We convert the proposed formulation into semidefinite optimization problem, which can be solved numerically using interior point methods. Finally, an extensive set of simulations validates the proposed algorithms.

  5. PERBEDAAN PERUSAHAN PENCIPTA ECONOMIC VALUE ADDED POSITIF DENGAN ECONOMIC VALUE ADDED NEGATIF

    Directory of Open Access Journals (Sweden)

    Suripto Suripto

    2017-03-01

    Full Text Available This research was to explain and analyze the different variable of Inflation Rate,Exchange Rate, Interest Rate, Ratio Plant Asset, Size Measure Company, Profitability, Growth ,LD / E, TD / TA, Stock of Return, Book To Market between company having Economic ValueAdded ( Positive and company having Economic Value Added ( Negative . Analysis which wasused in this research was multivariate analysis of variant (MANOVA. There was different variableof Inflation Rate, Exchange Rate, Interest Rate, Ratio Plant Asset, Size Measure Company,Profitability, Growth , LD / E, TD / TA, Stock of Return, Book To Market between companyhaving Economic Value Added ( Positive and negative EVA. However, by partial, only differentsale size was significant

  6. AD HOC Networks for the Autonomous Car

    Science.gov (United States)

    Ron, Davidescu; Negrus, Eugen

    2017-10-01

    The future of the vehicle is made of cars, roads and infrastructures connected in a two way automated communication in a holistic system. It is a mandatory to use Encryption to maintain Confidentiality, Integrity and Availability in an ad hoc vehicle network. Vehicle to Vehicle communication, requires multichannel interaction between mobile, moving and changing parties to insure the full benefit from data sharing and real time decision making, a network of such users referred as mobile ad hoc network (MANET), however as ad hoc networks were not implemented in such a scale, it is not clear what is the best method and protocol to apply. Furthermore the visibility of secure preferred asymmetric encrypted ad hoc networks in a real time environment of dense moving autonomous vehicles has to be demonstrated, In order to evaluate the performance of Ad Hoc networks in changing conditions a simulation of multiple protocols was performed on large number of mobile nodes. The following common routing protocols were tested, DSDV is a proactive protocol, every mobile station maintains a routing table with all available destinations, DSR is a reactive routing protocol which allows nodes in the MANET to dynamically discover a source route across multiple network hops, AODV is a reactive routing protocol Instead of being proactive. It minimizes the number of broadcasts by creating routes based on demand, SAODV is a secure version of AODV, requires heavyweight asymmetric cryptographic, ARIANDE is a routing protocol that relies on highly efficient symmetric cryptography the concept is primarily based on DSR. A methodical evolution was performed in a various density of transportation, based on known communication bench mark parameters including, Throughput Vs. time, Routing Load per packets and bytes. Out of the none encrypted protocols, It is clear that in terms of performance of throughput and routing load DSR protocol has a clear advantage the high node number mode. The encrypted

  7. A reference accelerator scheme for ADS applications

    Science.gov (United States)

    Biarrotte, Jean-Luc; Bousson, Sébastien; Junquera, Tomas; Mueller, Alex C.; Olivier, Aurélia

    2006-06-01

    Accelerator Driven Systems (ADS) for transmutation of nuclear waste typically require 350 MeV-1 GeV accelerators delivering proton fluxes of 5-10 mA for demonstrators, and 20-50 mA for large industrial systems. Thus, such machines belong to the category of the so-called HPPA (High-Power Proton Accelerators), with multi-megawatt beam power. HPPA are presently developed and constructed at great pace for their broad utility in fundamental or applied science. Compared to other HPPA, many features and requirements are similar for the ADS driver. However, there is a need for exceptional reliability: because of the induced thermal stress to the sub-critical core, the number of unwanted "beam-trips" should not exceed a few per year, a requirement that is several orders of magnitude above usual performance. Consecutive to the work of the European Technical Working Group (ETWG) on ADS, the Preliminary Design Study of an Experimental ADS (PDS-XADS) was launched in 2001 as a 5th Framework Program EC project. A special Working Package (WP3) was dedicated to the accelerator design, taking especially into account that the issue of "beam-trips" could be a potential "show-stopper" for ADS technology in general. A reference solution, based on a linear superconducting accelerator with its associated doubly achromatic beam line, has been worked out to some detail. For high reliability, the proposed design is intrinsically fault tolerant, relying on highly modular "de-rated" components associated to a fast digital feedback system. The proposed solution also appears to be robust concerning operational aspects like maintenance and radioprotection. A roadmap for construction as well as the required consolidated budget was elaborated. A program for the remaining R&D, focused on experimental reliability demonstration of prototypical components has been elaborated. This R&D will be performed in the 6th Framework Program EC project EUROTRANS, which presently is just starting. EC Contract No

  8. Effects of Flavonoid-rich Plant Extracts on Ruminal Methanogenesis, Microbial Populations and Fermentation Characteristics

    Directory of Open Access Journals (Sweden)

    Eun T. Kim

    2015-04-01

    Full Text Available The objective of this study was to evaluate the in vitro effects of flavonoid-rich plant extracts (PE on ruminal fermentation characteristics and methane emission by studying their effectiveness for methanogenesis in the rumen. A fistulated Holstein cow was used as a donor of rumen fluid. The PE (Punica granatum, Betula schmidtii, Ginkgo biloba, Camellia japonica, and Cudrania tricuspidata known to have high concentrations of flavonoid were added to an in vitro fermentation incubated with rumen fluid. Total gas production and microbial growth with all PE was higher than that of the control at 24 h incubation, while the methane emission was significantly lower (p<0.05 than that of the control. The decrease in methane accumulation relative to the control was 47.6%, 39.6%, 46.7%, 47.9%, and 48.8% for Punica, Betula, Ginkgo, Camellia, and Cudrania treatments, respectively. Ciliate populations were reduced by more than 60% in flavonoid-rich PE treatments. The Fibrobacter succinogenes diversity in all added flavonoid-rich PE was shown to increase, while the Ruminoccocus albus and R. flavefaciens populations in all PE decreased as compared with the control. In particular, the F. succinogenes community with the addition of Birch extract increased to a greater extent than that of others. In conclusion, the results of this study showed that flavonoid-rich PE decreased ruminal methane emission without adversely affecting ruminal fermentation characteristics in vitro in 24 h incubation time, suggesting that the flavonoid-rich PE have potential possibility as bio-active regulator for ruminants.

  9. D-instanton in AdS sub 5 and instanton in SYM sub 4

    CERN Document Server

    Chu, C S; Wu, Y Y

    1999-01-01

    Following the observation of Banks and Green that the D-instantons in AdS sub 5 correspond to the instantons in four-dimensional supersymmetric Yang-Mills theory, we study in more detail this correspondence for individual instantons. The supergravity solution for a D-instanton in AdS sub 5 is found using the ansatz used previously for D-instantons in flat space. We check that the actions and supersymmetries match between the D-instanton solution and the Yang-Mills instanton. Generalizing this result, we propose that any supergravity solution satisfying the ansatz corresponds to a (anti-) self-dual Yang-Mills configuration. Using this ansatz a family of identities for correlation functions in the supersymmetric Yang-Mills theory are derived.

  10. AdS5 vacua from type IIB supergravity on T 1 ,1

    Science.gov (United States)

    Louis, Jan; Muranaka, Constantin

    2017-06-01

    We study maximally supersymmetric Anti-de Sitter backgrounds in consistent \\mathcal{N}=2 truncations of type IIB supergravity compactified on the Sasaki-Einstein manifold T 1,1. In particular, we focus on truncations that contain fields coming from the nontrivial second and third cohomology forms on T 1,1. These give rise to \\mathcal{N}=2 super-gravity coupled to two vector- and two hypermultiplets (Betti-vector truncation) or one vector- and three hypermultiplets (Betti-hyper truncation), respectively. We find that both truncations admit AdS5 backgrounds with the gauge group always being broken but containing at least an U(1) R factor. Moreover, in both cases we show that the moduli space of AdS vacua is nontrivial and of maximal dimension. Finally, we explicitly compute the metrics on these moduli spaces.

  11. P-V criticality of AdS black holes in a general framework

    CERN Document Server

    Majhi, Bibhas Ranjan

    2016-01-01

    Interpreting the cosmological constant as pressure, it has been observed that AdS black holes behave as van der Waals system. The critical exponents for the phase transition for all AdS black holes are exactly same as those for the van der Waals system. Till now this has been observed case by case. Here, without using any specific form of the black hole metric, we present a general framework based on just two universal inputs. These are the general forms of the Smarr formula and the first law of thermodynamics. We find that the same values of the critical exponents can be obtained by this general analysis. Therefore there is no need to investigate for a particular metric. The importance of our analysis is that it highlights the observed universality, as well as revels the reason for such universality.

  12. Free field realization of superstring theory on AdS3

    Energy Technology Data Exchange (ETDEWEB)

    Hofman, Diego M. E-mail: dmhof@yahoo.com.ar; Nunez, Carmen A

    2004-07-01

    The Coulomb gas representation of expectation values in SU(2) conformal field theory developed by Dotsenko is extended to the SL(2,R) WZW model and applied to bosonic string theory on AdS3 and to Type II superstrings on AdS3 x N. The spectral flow symmetry is included in the free field realization of vertex operators creating superstring states of both Ramond and Neveu-Schwarz sectors. Conjugate representations for these operators are constructed and a background charge prescription is designed to compute correlation functions. Two and three point functions of bosonic and fermionic string states in arbitrary winding sectors are calculated. Scattering amplitudes that violate winding number conservation are also discussed. (author)

  13. AdS5 compactifications with punctures in massive IIA supergravity

    Science.gov (United States)

    Bah, Ibrahima; Passias, Achilleas; Tomasiello, Alessandro

    2017-11-01

    We find AdS5 solutions holographically dual to compactifications of six- dimensional N = (1, 0) supersymmetric field theories on Riemann surfaces with punctures. We simplify a previous analysis of supersymmetric AdS5 IIA solutions, and with a suitable Ansatz we find explicit solutions organized in three classes, where an O8-D8 stack, D6-and D4-branes are simultaneously present, localized and partially localized. The D4-branes are smeared over the Riemann surface and this is interpreted as the presence of a uniform distribution of punctures. For the first class we identify the corresponding six-dimensional theory as an E-string theory coupled to a quiver gauge theory. The second class of solutions lacks D6-branes and its central charge scales as n 5/2, suggesting a five-dimensional origin for the dual field theory. The last class has elements of the previous two.

  14. Bulk Fields and Supersymmetry in a Slice of AdS

    CERN Document Server

    Gherghetta, Tony; Gherghetta, Tony; Pomarol, Alex

    2000-01-01

    Five-dimensional models where the bulk is a slice of AdS have the virtue of solving the hierarchy problem. The electroweak scale is generated by a ``warp'' factor of the induced metric on the brane where the standard model fields live. However, it is not necessary to confine the standard model fields on the brane and we analyze the possibility of having the fields actually living in the slice of AdS. Specifically, we study the behaviour of fermions, gauge bosons and scalars in this geometry and their implications on electroweak physics. These scenarios can provide an explanation of the fermion mass hierarchy by warp factors. We also consider the case of supersymmetry in the bulk, and analyze the conditions on the mass spectrum. Finally, a model is proposed where the warp factor generates a small (TeV) supersymmetry-breaking scale, with the gauge interactions mediating the breaking to the scalar sector.

  15. Comments on Penrose Limit of AdS_4 x M^{1,1,1}

    OpenAIRE

    Ahn, Changhyun

    2002-01-01

    We construct a Penrose limit of AdS_4 x M^{1,1,1} where M^{1,1,1}= SU(3) x SU(2) x U(1)/(SU(2) x U(1) x U(1)) that provides the pp-wave geometry equal to the one in the Penrose limit of AdS_4 x S^7. There exists a subsector of three dimensional N=2 dual gauge theory which has enhanced N=8 maximal supersymmetry. We identify operators in the N=2 gauge theory with supergravity KK excitations in the pp-wave geometry and describe how the gauge theory operators made out of two kinds of chiral field...

  16. Non-Supersymmetric CS-Matter Theories with Known AdS Duals

    Directory of Open Access Journals (Sweden)

    Davide Forcella

    2011-01-01

    Full Text Available We consider three-dimensional conformal field theories living on a stack of N anti-M2 branes at the tip of eight-dimensional supersymmetric cones. The corresponding supergravity solution is obtained by changing sign to the four-form in the Freund-Rubin solution representing M2 branes (“skew-whiffing” transformation and it is known to be stable. The existence of these non-supersymmetric, stable field theories, at least in the large N limit, is a peculiarity of the AdS 4 / CFT 3 correspondence with respect to the usual AdS 5 / CFT 4 , and it is worthwhile to study it. We analyze in detail the KK spectrum of the skew-whiffed solution associated with S 7 / ℤ k and we speculate on the natural field content for a candidate non-supersymmetric dual field theory.

  17. Weak field collapse in AdS: introducing a charge density

    Energy Technology Data Exchange (ETDEWEB)

    Caceres, Elena [Facultad de Ciencias, Universidad de Colima,Bernal Diaz del Castillo 340, Colima (Mexico); Theory Group, Department of Physics and Texas Cosmology Center,The University of Texas at Austin,2515 Speedway Stop C1608, Austin, TX 78712 (United States); Kundu, Arnab [Department de Física Fondamental & Institut de Ciències del Cosmos,Universitat de Barcelona,Martí i Franquès 1, E-08028 Barcelona (Spain); Saha Institute of Nuclear Physics,1/AF Bidhannagar, Kolkata 700064 (India); Pedraza, Juan F. [Theory Group, Department of Physics and Texas Cosmology Center,The University of Texas at Austin,2515 Speedway Stop C1608, Austin, TX 78712 (United States); Perimeter Institute for Theoretical Physics,31 Caroline Street North Waterloo, Ontario N2L 2Y5 (Canada); Yang, Di-Lun [Crete Center for Theoretical Physics, Department of physics, University of Crete,71003, Heraklion (Greece); Department of physics, Chung-Yuan Christian University,Chung Pei Road, Chung-Li 32023, Taiwan (China)

    2015-06-17

    We study the effect of a non-vanishing chemical potential on the thermalization time of a strongly coupled large N{sub c} gauge theory in (2+1)-dimensions, using a specific bottom-up gravity model in asymptotically AdS space. We first construct a perturbative solution to the gravity-equations, which dynamically interpolates between two AdS black hole backgrounds with different temperatures and chemical potentials, in a perturbative expansion of a bulk neutral scalar field. In the dual field theory, this corresponds to a quench dynamics by a marginal operator, where the corresponding coupling serves as the small parameter in which the perturbation is carried out. The evolution of non-local observables, such as the entanglement entropy, suggests that thermalization time decreases with increasing chemical potential. We also comment on the validity of our perturbative analysis.

  18. Hawking Radiation-Quasinormal Modes Correspondence for Large AdS Black Holes

    Directory of Open Access Journals (Sweden)

    Dao-Quan Sun

    2017-01-01

    Full Text Available It is well-known that the nonstrictly thermal character of the Hawking radiation spectrum generates a natural correspondence between Hawking radiation and black hole quasinormal modes. This main issue has been analyzed in the framework of Schwarzschild black holes, Kerr black holes, and nonextremal Reissner-Nordstrom black holes. In this paper, by introducing the effective temperature, we reanalyze the nonstrictly thermal character of large AdS black holes. The results show that the effective mass corresponding to the effective temperature is approximatively the average one in any dimension. And the other effective quantities can also be obtained. Based on the known forms of frequency in quasinormal modes, we reanalyze the asymptotic frequencies of the large AdS black hole in three and five dimensions. Then we get the formulas of the Bekenstein-Hawking entropy and the horizon’s area quantization with functions of the quantum “overtone” number n.

  19. Correlation functions in the CFT sub d /AdS sub d sub + sub 1 correspondence

    CERN Document Server

    Freedman, D Z; Matusis, A; Rastelli, L

    1999-01-01

    Conformal techniques are applied to the calculation of integrals on AdS sub d sub + sub 1 space which define correlators of composite operators in the superconformal field theory on the d-dimensional boundary. The 3-point amplitudes for scalar fields of arbitrary mass and gauge fields in the AdS supergravity are calculated explicitly. For three gauge fields we compare in detail with the known conformal structure of the SU(4) flavor current correlator of the N = 4, d = 4 SU(N) SYM theory. Results agree with the free field approximation as would be expected from superconformal non-renormalization theorems. In studying the Ward identity relating to for (non-marginal) scalar composite operators O sup I , we find that there is a subtlety in obtaining the normalization of from the supergravity action integral.

  20. Symmetry operators of Killing spinors and superalgebras in AdS5

    Science.gov (United States)

    Ertem, Ümit

    2016-04-01

    We construct the first-order symmetry operators of Killing spinor equation in terms of odd Killing-Yano forms. By modifying the Schouten-Nijenhuis bracket of Killing-Yano forms, we show that the symmetry operators of Killing spinors close into an algebra in AdS5 spacetime. Since the symmetry operator algebra of Killing spinors corresponds to a Jacobi identity in extended Killing superalgebras, we investigate the possible extensions of Killing superalgebras to include higher-degree Killing-Yano forms. We found that there is a superalgebra extension but no Lie superalgebra extension of the Killing superalgebra constructed out of Killing spinors and odd Killing-Yano forms in AdS5 background.

  1. Phases of planar AdS black holes with axionic charge

    Science.gov (United States)

    Caldarelli, Marco M.; Christodoulou, Ariana; Papadimitriou, Ioannis; Skenderis, Kostas

    2017-04-01

    Planar AdS black holes with axionic charge have finite DC conductivity due to momentum relaxation. We obtain a new family of exact asymptotically AdS4 black branes with scalar hair, carrying magnetic and axion charge, and we study the thermodynamics and dynamic stability of these, as well as of a number of previously known electric and dyonic solutions with axion charge and scalar hair. The scalar hair for all solutions satisfy mixed boundary conditions, which lead to modified holographic Ward identities, conserved charges and free energy, relative to those following from the more standard Dirichlet boundary conditions. We show that properly accounting for the scalar boundary conditions leads to well defined first law and other thermodynamic relations. Finally, we compute the holographic quantum effective potential for the dual scalar operator and show that dynamical stability of the hairy black branes is equivalent to positivity of the energy density.

  2. Finite-size corrections for quantum strings on AdS4 x CP3

    DEFF Research Database (Denmark)

    Astolfi, D.; Puletti, V.G.M.; Grignani, G.

    2011-01-01

    We revisit the calculation of curvature corrections to the pp-wave energy of type IIA string states on AdS4×CP3 initiated in arXiv:0807.1527. Using the near pp-wave Hamiltonian found in arXiv:0912.2257, we compute the first non-vanishing correction to the energy of a set of bosonic string states...

  3. Logarithmic corrections to entropy of magnetically charged AdS4 black holes

    Science.gov (United States)

    Jeon, Imtak; Lal, Shailesh

    2017-11-01

    Logarithmic terms are quantum corrections to black hole entropy determined completely from classical data, thus providing a strong check for candidate theories of quantum gravity purely from physics in the infrared. We compute these terms in the entropy associated to the horizon of a magnetically charged extremal black hole in AdS4×S7 using the quantum entropy function and discuss the possibility of matching against recently derived microscopic expressions.

  4. Generalized thermodynamic identity and new Maxwell's law for charged AdS black hole

    CERN Document Server

    Zhao, Zixu

    2016-01-01

    We study the thermodynamic properties of the RN-AdS black hole in full phase space and propose a generalized thermodynamic identity. As an example, we use it to find relations of thermodynamical coefficients between the grand canonical and canonical ensembles. We also show, for the first order phase transition, that the usual Maxwell's equal area law should be extended to a new form for the RN-AdS black hole.

  5. State Operator Correspondence and Entanglement in AdS2/CFT1

    Directory of Open Access Journals (Sweden)

    Ashoke Sen

    2011-07-01

    Full Text Available Since Euclidean global AdS2 space represented as a strip has two boundaries, the state-operator correspondence in the dual CFT1 reduces to the standard map from the operators acting on a single copy of the Hilbert space to states in the tensor product of two copies of the Hilbert space. Using this picture we argue that the corresponding states in the dual string theory living on AdS2 × K are described by the twisted version of the Hartle–Hawking states, the twists being generated by a large unitary group of symmetries that this string theory must possess. This formalism makes natural the dual interpretation of the black hole entropy—as the logarithm of the degeneracy of ground states of the quantum mechanics describing the low energy dynamics of the black hole, and also as an entanglement entropy between the two copies of the same quantum theory living on the two boundaries of global AdS2 separated by the event horizon.

  6. Plastik Sanatlarda Adli Vaka İmgeleri

    Directory of Open Access Journals (Sweden)

    Necla Rüzgar Kayıran

    2014-04-01

    Full Text Available Resim sanatıyla adli tıp arasındaki ilişkiye baktığımızda en temelde şu ayrımı görürüz: Adli tıp bir cinayeti kurban üzerinden değil, katil üzerinden düşünme eğilimindedir. Oysa resim sanatı bir cinayeti konu ederken kurban üzerinden düşünme, söz konusu katil bile olsa katili de “kurban” olarak imgeselleştirme eğilimindedir. Örneğin Caravaggio cinayet işlemiş bir sanatçıdır. Bu cinayetten duyduğu pişmanlığı “Goliath'ın Başını Kesen Davud” adlı resimle imgeselleştirir. Sanatçı, otoportresinde katil-kurban imgelerinin yer değiştiren döngüsüyle mücadele içindedir. Kesik kulağıyla Van Gogh’un, şiddete uğramış haliyle Nan Goldin’in otoportreleri yine sanatçıların kurban olarak kendilerini ifadelerinin çarpıcı birer örneğidir. Gericault’nun öldürülen suçluların kesik başlarına gizli ve derin bir şefkat eklemesi, Goya’nın parçalanarak terkedilmiş beden parçalarına resimleri aracılığıyla sahip çıkması sanatçıların cezalandırılmış suçlulara başka bir açıdan bakmamızı öneren yapıtlarına örnektir. Karakteristik adli vaka örnekleri olarak David’in “Marat’ın Ölümü” ya da Magritte’in “Tehdit Altındaki Katil” adlı resimlerinin “olay yeri” bulgularının imgesel dizilimiyle dolu olduklarını görebiliriz. Rembrandt’ın “Dr. Nicolaes Tulp’un Anatomi Dersi” adlı resmi, doktorlarla sanatçıların bakış açısındaki farkı göstermek açısından sembolik bir örnektir. Rembrandt, Aris Kindt’in elini değil, ayak ucunda duran anatomi atlasındaki eli resmetmiştir. Doktorların tümü anatomi atlasına bakarken, sanatçı, izleyicileri ölü bedene yöneltir ve bu noktadan görünen artık bir kurbana dönüşmüş olan Aris Kindt’dir. Adli tıp’ta incelenen “deliller/sonuçlar” bizi “katile/suçluya” ulaşırken, sanat tarihindeki imgeler bizi “kurbana” ulaştırır. Anahtar Kelimeler

  7. Adília Lopes – ironista

    Directory of Open Access Journals (Sweden)

    Rosa Maria Martelo

    2004-10-01

    Full Text Available O nome Adília Lopes tanto designa uma leitora profundamente interessada pela tradição poética erudita como uma assumida “poetisa pop”. E enquanto a primeira gosta de recordar referências fundamentais da Modernidade, de Rimbaud a Apollinaire, de Cesário a Pessoa, derivando para Sophia, Herberto Helder ou Sylvia Plath, ou facilmente recua no tempo literário ocidental até Diderot, S. João da Cruz e Virgílio, a segunda parece valorizar mais todo um outro universo de escrita, no qual avultam os contos infantis, as leituras da adolescência, o folhetinesco e o fait-divers das revistas femininas. Sem nunca pôr de parte as referências literárias de Adília-leitoraerudita, é sobretudo este o mundo que a “poetisa pop” gosta de reescrever, mostrando até que ponto ele é atravessado por uma insidiosa crueldade e tornando indistintas as fronteiras que o separavam (separam? da Literatura. Entre cultura erudita e cultura de massas, entre referências eruditas e uma linguagem muito próxima dos registros orais pouco vigiados, usando um verso que, por vezes, parece premeditadamente distraído num ritmo muito fácil, Adília Lopes faz apelo à memória de um mundo adolescente onde o bem e o mal, o alto e o baixo, o bom e o mau gosto pareciam irredutivelmente distintos, para tudo indiferenciar, agora, com dessacralizadora ironia. 

  8. Interpolated Sounding Value-Added Product

    Energy Technology Data Exchange (ETDEWEB)

    Troyan, D [Brookhaven National Laboratory

    2013-04-01

    The Interpolated Sounding (INTERPSONDE) value-added product (VAP) uses a combination of observations from radiosonde soundings, the microwave radiometer (MWR), and surface meteorological instruments in order to define profiles of the atmospheric thermodynamic state at one-minute temporal intervals and a total of at least 266 altitude levels. This VAP is part of the Merged Sounding (MERGESONDE) suite of VAPs. INTERPSONDE is the profile of the atmospheric thermodynamic state created using the algorithms of MERGESONDE without including the model data from the European Centre for Medium-range Weather Forecasting (ECMWF). More specifically, INTERPSONDE VAP represents an intermediate step within the larger MERGESONDE process.

  9. ADS-B- Automatic Dependent Surveillance- Broadcast

    Directory of Open Access Journals (Sweden)

    Borivoj Galović

    2002-01-01

    Full Text Available The CU/Tent system of air traffic is facing many drawbacksand problems that restrict its further development and makes itdifficult to follow the trends of increase in the traffic volume.By means of their technology, the systems such as ADS-8create rhe basis for further building, upgrading, improving anddeveloping of a completely new concept of the air traffic system.Through their functions they fully fit into and support the basicfunctions of communication, navigation and swveillancewhich form the basis of the new concept that needs to be implementedas soon as possible.

  10. The concept of added value of FM

    DEFF Research Database (Denmark)

    Jensen, Per Anker; van der Voordt, Theo; Coenen, Christian

    2012-01-01

    Management (CREM) and Business to Business Marketing (B2B Marketing). Findings: The research shows different definitions and focus points, dependent on the academic field and the area of application. The different research perspectives explored a holistic view on the added value of FM by the integration...... of an external market based view (with a focus on the aimed output) and the internal resource based view (with a focus on the input from FM and real estate). Good relationship management and building on trust shows to be equally important as delivering the agreed services. Practical implications: A clear...

  11. Visual attention: the interplay between ad characteristics and context factors

    NARCIS (Netherlands)

    Boerman, S.; Smit, E.; van Meurs, A.

    2011-01-01

    Using eye-tracking data, we tested what elements of the ad are able to catch the eye and whether the context of the ad can draw visual attention away. Characteristics of 183 magazine ads and their direct context were systematically coded and linked to eye-tracking data. Results showed that indeed ad

  12. Recent highlights from the CERN-AD

    CERN Document Server

    Tranquille, Gerard

    2004-01-01

    The Antiproton Decelerator and cooling ring (AD) provides dense and cold beams of antiprotons to low energy experiments for the study of basic properties of antiprotons and antihydrogen. It combines stochastic cooling (at 3.5 and 2GeV/c) with electron cooling at 0.3 and 0.1GeV/c. In 2002 the AD gave beam during more than 1900h to its three experiments (ASACUSA, ATHENA and ATRAP) with beam properties meeting, and often exceeding design specification. Stochastic cooling with cool-down times of 18s works as aimed for in the design. Electron cooling using the "old LEAR cooler" reaches the very small equilibrium emittances required but still takes more time (12s instead of 6s anticipated in the 1996 design). However the increase in cycle length is made up for by the higher deceleration efficiency. ASACUSA has very successfully continued the program of antiprotonic helium 3 spectroscopy and ATHENA and ATRAP have reported last autumn the synthesis of copious numbers of cold antihydrogen atoms.

  13. Added values of photovoltaic power systems

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-15

    The structure, ownership and operation of electricity systems around the world are changing in response to industry restructuring, the availability of new technologies and increasing environmental awareness. At the same time, many countries have yet to provide basic energy services for their populations, particularly in areas not served by the electricity grid. Large-scale, central power generation and distribution which characterized the electricity industry for much of the 20{sup th} century is being challenged by new technologies, which are cleaner, faster to deploy and better matched to local requirements. Higher values are being placed on ancillary services, such as power system reliability and voltage stability, so that a simple comparison of energy cost is no longer appropriate as a measure of competitiveness. Solar photovoltaic electricity is unique amongst the new energy sources for the wide range of energy and non-energy benefits which can be provided, while the use of photovoltaic power systems as an integral part of a building provides the greatest opportunity for exploiting non-energy benefits and for adding value to the photovoltaic power system. This report documents the potential added values or non-energy benefits photovoltaic power systems can provide, the current state of market development and the key barriers faced by renewable energy technologies generally and photovoltaic power systems in particular. Means by which non-energy benefits may be used to overcome barriers to the use of photovoltaic power systems are then discussed, with specific attention to the use of building integrated photovoltaics. (author)

  14. POSSIBLE CHROMOSPHERIC ACTIVITY CYCLES IN AD LEO

    Energy Technology Data Exchange (ETDEWEB)

    Buccino, Andrea P.; Petrucci, Romina; Mauas, Pablo J. D. [Instituto de Astronomía y Física del Espacio (CONICET-UBA), C.C. 67 Sucursal 28, C1428EHA-Buenos Aires (Argentina); Jofré, Emiliano [Observatorio Astronómico de Córdoba, Córdoba (Argentina)

    2014-01-20

    AD Leo (GJ 388) is an active dM3 flare star that has been extensively observed both in the quiescent and flaring states. Since this active star is near the fully convective boundary, studying its long-term chromospheric activity in detail could be an appreciable contribution to dynamo theory. Here, using the Lomb-Scargle periodogram, we analyze the Ca II K line-core fluxes derived from CASLEO spectra obtained between 2001 and 2013 and the V magnitude from the ASAS database between 2004 and 2010. From both of these totally independent time series, we obtain a possible activity cycle with a period of approximately seven years and a less significant shorter cycle of approximately two years. A tentative interpretation is that a dynamo operating near the surface could be generating the longer cycle, while a second dynamo operating in the deep convection zone could be responsible for the shorter one. Based on the long duration of our observing program at CASLEO and the fact that we observe different spectral features simultaneously, we also analyze the relation between simultaneous measurements of the Na I index (R{sub D}{sup ′}), Hα, and Ca II K fluxes at different activity levels of AD Leo, including flares.

  15. AD Consolidation for operation beyond 2010

    CERN Document Server

    Eriksson, T

    2008-01-01

    The Antiproton Decelerator (AD), which started up for physics in 2000 and today supplies low-energy antiprotons to the ATRAP, ALPHA, ASACUSA and ACE experiments is based on the ACOL machine from which it still retains most of the components. ACOL construction was completed in 1986 at a total cost of approximately 80 MCHF (excluding infrastructure) which today would correspond to a value of around 160 MCHF. During recent years, a reduction of maintenance and modernisation has been unavoidable due to budgetary restraints. In order to identify the resources needed for continued AD operation beyond 2010 with a reasonably low risk of failures and to avoid increasing maintenance and repair costs, a study has been conducted involving groups from the AB, AT and TS departments. Analysis of breakdown risks, identification of items and costs for consolidation has been done as well as a risk score classification. To be noted is the relatively modest cost of the proposed items in view of the value of the facility and in c...

  16. The AD: The unique anti-accelerator

    CERN Multimedia

    Slide show by Maximilien Brice. Voice (French only): Jacques Fichet. Content: Paola Catapano, Django Manglunki, CERN Bulletin

    2011-01-01

    Unlike other machines whose performance is measured in terms of energy records, AD's uniqueness resides in the fact that it can very effectively decelerate beams. At the hearth of antimatter production at CERN, the AD is making headlines in the world's press. This provides an excellent opportunity for us to retrace its history in images.   var flash_video_player=get_video_player_path(); insert_player_for_external('Video/Public/Movies/2011/CERN-MOVIE-2011-083/CERN-MOVIE-2011-083-0753-kbps-480x360-25-fps-audio-64-kbps-44-kHz-stereo', 'mms://mediastream.cern.ch/MediaArchive/Video/Public/Movies/2011/CERN-MOVIE-2011-083/CERN-MOVIE-2011-083-0480-kbps-384x288-25-fps-audio-128-kbps-48-kHz-stereo.wmv', 'false', 480, 360, 'http://mediaarchive.cern.ch/MediaArchive/Video/Public/Movies/2011/CERN-MOVIE-2011-083/CERN-MOVIE-2011-083-posterframe-480x360-at-5-percent.jpg', '1357551', true, '');  

  17. An alternative path to the boundary: The CFT as the Fourier space of AdS

    Science.gov (United States)

    Tolfree, Ian M.

    2009-12-01

    In this thesis we shed new light on the conjectured duality between an n + 1 dimensional theory of gravity in anti de Sitter space (AdS) and an n dimensional conformal field theory (CFT) by showing that the CFT can be interpreted as the Fourier space of AdS. We then make use of this to gain insight into the nature of black hole entropy. In the first part of this thesis, we give an introduction to the ideas of and review the basics of the AdS/CFT. In the next section we make use of well known integral geometry techniques to derive the Fourier transformation of a function on AdS and see it is a function with compact support on the boundary. Comparing this to the literature, we find that the Green's functions from the literature are actually the Fourier weights of the transformation and that the boundary values of fields appearing in the correspondence are the Fourier coefficients of the transformation. One is thus left to interpret the CFT as the quantized version of a classical theory in AdS and the dual operator as the Fourier coefficients. Group theoretic considerations are discussed in relation to the transformation and its potential use in constructing QCD like theories. In the last section, we then build upon this to study the BTZ black hole. Named after its authors, Banados, Teitelboim and Zanelli, the BTZ black hole is a three dimensional (two space plus one time dimension) black hole in anti de Sitter space. Following standard procedures for modifying Fourier Transformations to accommodate quotient spaces we arrive at a mapping in a black hole background consistent with known results that yields the exact micro-states of a scalar field in a black hole background. We find that the micro-states are the Fourier coefficients on the boundary, which transform under the principal series representation of SL(2, R). Using the knowledge of how to represent a bulk scalar field in the CFT, and knowing how a black hole interacts with a scalar field, we deduce the

  18. Natural compounds as corrosion inhibitors for highly cycled systems

    Energy Technology Data Exchange (ETDEWEB)

    Quraishi, M.A.; Farooqi, I.H.; Saini, P.A. [Corrosion Research Lab., Aligarh (India)

    1999-11-01

    Strict environmental legislations have led to the development of green inhibitors in recent years. In continuation of the authors` research work on development of green inhibitors, they have investigated the aqueous extracts of three plants namely: Azadirachta indica, Punica Granatum and Momordica charantia as corrosion inhibitors for mild steel in 3% NaCl using weight loss and electrochemical methods. All the investigated compounds exhibited excellent corrosion inhibition properties comparable to that of HEDP. Azadirachta showed better scale inhibition effect than HEDP.

  19. In vitro Antifungal Activity of Different Plant Extracts against Phytophthora infestans the Causal Agent of Potato Late Blight

    OpenAIRE

    Saida Messgo-Moumene; Rym Boukhalfa; Djazia Belaïdi; Lyes Beninal; Siham Haddadj-Hamdi; Mohamed Bellatreche

    2017-01-01

    Our study aimed to evaluate the in vitro antifungal activity of aqueous extracts prepared from seven medicinal plants (Carya illinoinensis, Equisetum arvense, Rosmarinus officinalis, Pistacia lentiscus, Mentha suaveolens, Punica granatum, and Posidonia oceanica) against A1 and A2 isolates of Phytophthora infestans the causal agent of potato late blight. The crude (100%) plant extracts were prepared by decoction and tested at various concentrations (70, 50, 30 and 10% v/v) for dete...

  20. Efek Ekstrak Pomegranat terhadap Kadar Malondialdehida dan Pembuluh Darah Jantung Tikus

    Directory of Open Access Journals (Sweden)

    Feri Fadillah

    2016-06-01

    Full Text Available Pomegranat (Punica granatum adalah buah yang mengandung antioksidan tinggi. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak pomegranat terhadap kadar malondialdehyde (MDA dan gambaran mikroskopik pembuluh darah jantung tikus. Penelitian eksperimental menggunaan tikus strain sprague dawley yang dipajankan asap rokok 2-3 jam perhari selama 2 minggu. Tikus dibagi menjadi tiga kelompok: kelompok pertama sebagai kontrol positif, kelompok kedua mendapatkan ekstrak pomegranat 5% dan kelompok ketiga mendapatkan ekstrak pomegranat k 10%. Pengambilan sampel dilakukan pada awal penelitian, hari ke-8 dan hari ke-15. Hasil analisis menunjukkan kadar MDA lebih tinggi pada kelompok tikus kontrol dibandingkan dengan kelompok tikus intervensi (p<0,05. Gambaran mikroskopik menunjukkan kerusakan sel endotel dan perdarahan mikro di pembuluh darah tikus sebagai dampak hipoksia jaringan.Kata kunci: Punica granatum, malondialdehida, pembuluh darahEffect of Pomegranate’s Extract to Malondialdehyde Level andRat’s Heart VesselAbstractPomegranate (Punica granatum contains high level of antioxidant. The aim of this study is to evaluate the effect of pomegranate extract on MDA level and histopatological findings in rat’s heart vessel that is exposed to cigarette smoking. Experimental study included sprague dawley rats that were exposed to cigarette smoke 2-3 hours a day for 2 weeks. The rats were divided into 3 groups: the first group was a control group, the second group received 5% pomegranate extract, and the third group was given 10% pomegranate extract. Measurement of MDA levels was done before and after the intervention (at the 8th day and 15th day. The MDA levels were significantly higher in control group than those among intervention group (p<0,05. Histopathological finding showed damage of endothelial cell and microhemorrhagic in rat’s heart vessel due to tissue hypoxia.Keywords: Punica granatum, malondialdehyde, heart vessel

  1. Critical Phenomena in Higher Curvature Charged AdS Black Holes

    Directory of Open Access Journals (Sweden)

    Arindam Lala

    2013-01-01

    Full Text Available In this paper, we have studied the critical phenomena in higher curvature charged AdS black holes. We have considered Lovelock-Born-Infeld-AdS black hole as an example. The thermodynamics of the black hole have been studied which reveals the onset of a higher-order phase transition in the black hole in the canonical ensemble (fixed charge ensemble framework. We have analytically derived the critical exponents associated with these thermodynamic quantities. We find that our results fit well with the thermodynamic scaling laws and consistent with the mean field theory approximation. The suggestive values of the other two critical exponents associated with the correlation function and correlation length on the critical surface have been derived.

  2. Phases of planar AdS black holes with axionic charge

    Energy Technology Data Exchange (ETDEWEB)

    Caldarelli, Marco M.; Christodoulou, Ariana [Mathematical Sciences and STAG Research Centre, University of Southampton,Highfield, Southampton SO17 1BJ (United Kingdom); Papadimitriou, Ioannis [SISSA and INFN - Sezione di Trieste,Via Bonomea 265, I 34136 Trieste (Italy); Skenderis, Kostas [Mathematical Sciences and STAG Research Centre, University of Southampton,Highfield, Southampton SO17 1BJ (United Kingdom)

    2017-04-03

    Planar AdS black holes with axionic charge have finite DC conductivity due to momentum relaxation. We obtain a new family of exact asymptotically AdS{sub 4} black branes with scalar hair, carrying magnetic and axion charge, and we study the thermodynamics and dynamic stability of these, as well as of a number of previously known electric and dyonic solutions with axion charge and scalar hair. The scalar hair for all solutions satisfy mixed boundary conditions, which lead to modified holographic Ward identities, conserved charges and free energy, relative to those following from the more standard Dirichlet boundary conditions. We show that properly accounting for the scalar boundary conditions leads to well defined first law and other thermodynamic relations. Finally, we compute the holographic quantum effective potential for the dual scalar operator and show that dynamical stability of the hairy black branes is equivalent to positivity of the energy density.

  3. Implementation of Economic Value Added and Market Value Added Analysis as Valuation Tools of Invest Feasibility

    Directory of Open Access Journals (Sweden)

    Achmad Daengs GS

    2017-09-01

    Full Text Available For the investors, financial statement is a benchmark of investors in assessing the company's performance. In fact, investors are not always receiving the accurate company's financial statements information and its levels of fairness are in doubt. The financial statement analysis with using financial ratios is not enough. The investors may need to use alternatives financial statement analyses techniques that reflect the actual company's performance. Therefore, both of the investors and the prospective can use Economic Value Added (EVA and Market Value Added (MVA analysis. With these technical analyses, the investors may know the company's performance where they are invested or to be used as a place to invest whether it has value added or not. With the results of these analyses, it is the expected for the investors to be more confident in making decision whether to buy, sell or hold the ownership in the company.

  4. Super 0-brane and GS superstring actions on AdS sub 2 x S sup 2

    CERN Document Server

    Zhou Jian Ge

    1999-01-01

    The super 0-brane and GS superstring actions on AdS sub 2 x S sup 2 background with 2-form flux are constructed by taking a supercoset approach. We find that the super 0-brane action contains two parameters which are interpreted as the electric and magnetic charges of the super 0-brane. The obtained super 0-brane action describes the BPS saturated dyonic superparticle moving on AdS sub 2 x S sup 2 background. The WZ action contains the required coupling with 2-form flux. For GS superstring, we find the string action on AdS sub 2 x S sup 2 takes the same form as those in AdS sub 3 x S sup 3 and AdS sub 5 x S sup 5 with RR field background.

  5. Climate Since A.D. 1500

    Science.gov (United States)

    Fleming, James R.

    The editors of this impressive volume are to be congratulated for gathering a stellar collection of thirty-three authoritative papers on the most recent period of climate history. In addition to providing thirty-three pages of introduction and conclusion, the editors also coauthored two important papers for the volume. This book will become a standard reference for the interdisciplinary climatic change community.Climate Since A.D. 1500 is divided into four sections: documentary evidence, dendroclimatic evidence, ice-core evidence, and forcing factors. In all, there are twelve papers using documentary evidence, eleven using dendroclimatic evidence, five on ice-core evidence, and three on forcing factors. The documentary papers cover Canada, the northeastern United States, Ireland, central Europe, northern Italy, the former Soviet Union, China, and Japan, with temporal coverage ranging from 1500 to very near the present.

  6. Adding crumb rubber into exterior wall materials.

    Science.gov (United States)

    Zhu, Han; Thong-On, Norasit; Zhang, Xiong

    2002-10-01

    In Arizona US, most houses are built with walls covered by stuccos/coatings/mortars. This paper presents an explorative investigation of adding crumb rubber into stuccos/coatings/mortars. A series of experiments are conducted to examine the thermal and mechanical performance of the crumb rubber mixes. The results show that, the mixes with crumb rubber do exhibit more desirable performances like being high in crack-resistance and thermal insulation, and low in thermal expansion/contraction. The drawback for the crumb rubber mixes is the reduction in compressive strength, but which can be compensated by other means. As a site experiment, an area of 100 square-feet of crumb rubber coatings for two mix designs is sprayed on a tire-adobe wall. After being sprayed more than 14 months, the coatings apparently are in good condition. Significance of this study is that this practice, if accepted, will yield improved products that consume large quantities of crumb rubber.

  7. AORTA: Adding Organizational Reasoning to Agents

    DEFF Research Database (Denmark)

    Jensen, Andreas Schmidt; Dignum, Virginia

    2014-01-01

    the expected behavior of the agents. Agents need to be able to reason about the regulations, so that they can act within the expected boundaries and work towards the objectives of the organization. This extended abstract introduces AORTA, a component that can be integrated into agents’ reasoning mechanism......Open systems are characterized by a diversity of heterogeneous and autonomous agents that act according to private goals, and with a behavior that is hard to predict. They can be regulated through organizations similar to human organizations, which regulate the agents’ behavior space and describe......, allowing them to reason about (and act upon) regulations specified by an organizational model using simple reasoning rules. The added value is that the organizational model is independent of that of the agents, and that the approach is not tied to a specific organizational model....

  8. [Did Henrik Wergeland have AD/HD?].

    Science.gov (United States)

    Aanonsen, Nils Olav

    2008-12-18

    Henrik Wergeland (1808 - 45) is one of Norwegian cultural history's most notable figures. He is honoured as a national symbol during this year's 200-year jubilee for his birth. Biographies and numerous academic publications have been written about him for more than 100 years. His life was short and diverse; on one hand he continuously worked to give people general education, he was an author and a poet and on the other hand he was always in a dispute with someone and involved in endless court cases and scandals. After his death it was said that Wergeland was one who . As I see it, his life is so full of events that indicate hyperactivity and impulsivity that I think it is legitimate to ask whether he would have received the diagnosis AD/HD (attention-deficit/ hyperactivity disorder) today.

  9. Quantum states of the spacetime, and formation of black holes in AdS

    CERN Document Server

    Botta Cantcheff, Marcelo

    2012-01-01

    We argue that a non-perturbative description of quantum gravity should involve two (non-interacting) copies of a dual field theory on the boundary, and describe the states of the spacetimes accordingly. So, for instance, a complete description of the asymptotically Anti-de-Sitter spacetimes is given by two copies of the conformal field theory associated to the global AdS spacetime. We also argue that, in this context, gravitational collapse and formation of a black hole may be described by unitary evolution of the dual non-perturbative degrees of freedom.

  10. Ehrenfest's scheme and thermodynamic geometry in Born-Infeld AdS black holes

    CERN Document Server

    Lala, Arindam

    2011-01-01

    In this paper we analyze the phase transition phenomena in Born-Infeld AdS black holes using Ehrenfest's scheme of standard thermodynamics. The critical points are marked by the divergences in the heat capacity. In order to investigate the nature of the phase transition, we analytically check both the Ehrenfest's equations near the critical points. Our analysis reveals that this is indeed a second order phase transition. Finally, we analyze the nature of the phase transition using state space geometry approach. This is found to be compatible with the Ehrenfest's scheme.

  11. On heat properties of AdS black holes in higher dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Belhaj, A. [Département de Physique, Faculté Polydisciplinaire, Université Sultan M. Slimane,Béni Mellal (Morocco); High Energy Physics and Astrophysics Laboratory, FSSM, Cadi Ayyad University,Marrakesh (Morocco); Chabab, M.; Moumni, H. El; Masmar, K. [High Energy Physics and Astrophysics Laboratory, FSSM, Cadi Ayyad University,Marrakesh (Morocco); Sedra, M.B. [Université Mohammed Premier, Ecole Nationale des Sciences Appliquées,Al Hoceima (Morocco); Département de Physique, LHESIR, Faculté des Sciences, Université Ibn Tofail,Kénitra (Morocco); Segui, A. [Departamento de Física Teórica, Universidad de Zaragoza,E-50009-Zaragoza (Spain)

    2015-05-28

    We investigate the heat properties of AdS Black Holes in higher dimensions. We consider the study of the corresponding thermodynamical properties including the heat capacity explored in the determination of the black hole stability. In particular, we compute the heat latent. To overcome the instability problem, the Maxwell construction, in the (T,S)-plane, is elaborated. This method is used to modify the the Hawking-Page phase structure by removing the negative heat capacity regions. Then, we discuss the thermodynamic cycle and the heat engines using the way based on the extraction of the work from a black hole solution.

  12. Bounds on CFTs with W3 algebras and AdS3 higher spin theories

    Science.gov (United States)

    Apolo, Luis

    2017-10-01

    The scaling dimension of the first excited state in two-dimensional conformal field theories (CFTs) satisfies a universal upper bound. Using the modular bootstrap, we extend this result to CFTs with W3 algebras which are generically dual to higher spin theories in AdS3 . Assuming unitarity and modular invariance, we show that the conformal weights h , h ¯ of the lightest charged state satisfy h 4 |h -c /24 |/√{10 π c }+O (1 ) . We discuss hints on the existence of stronger bounds and comment on the interpretation of our results in the dual higher spin theory.

  13. Frozen yogurt with added inulin and isomalt.

    Science.gov (United States)

    Isik, U; Boyacioglu, D; Capanoglu, E; Erdil, D Nilufer

    2011-04-01

    The objective of this study was to produce a frozen yogurt containing low fat and no added sugar. Samples containing 5% polydextrose, 0.065% aspartame and acesulfame-K mixture, and different levels of inulin and isomalt (5.0, 6.5, and 8.0%) were produced at pilot scale and analyzed for their physical and chemical properties including proximate composition, viscosity, acidity, overrun, melting rate, heat shock stability, as well as sensory characteristics, and viability of lactic acid bacteria. With the addition of inulin and isomalt, viscosity increased by 19 to 52% compared with that of sample B (reduced-fat control). The average calorie values of samples substituted with sweeteners were about 43% lower than that of original sample. Low-calorie frozen yogurt samples melted about 33 to 48% slower than the reduced-fat control sample at 45 min. Based on quantitative descriptive profile test results, statistically significant differences among products were observed for hardness, iciness, foamy melting, whey separation, and sweetness characteristics. The results of principal component analysis showed that the sensory properties of the sample containing 6.5% inulin and 6.5% isomalt were similar to those of control. Lactic acid bacteria counts of frozen yogurt were found to be between 8.12 and 8.49 log values, 3 mo after the production. The overall results showed that it is possible to produce an attractive frozen yogurt product with the incorporation of inulin and isomalt with no added sugar and reduced fat. Copyright © 2011 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  14. Detecting Anti Ad-blockers in the Wild

    Directory of Open Access Journals (Sweden)

    Mughees Muhammad Haris

    2017-07-01

    Full Text Available The rise of ad-blockers is viewed as an economic threat by online publishers who primarily rely on online advertising to monetize their services. To address this threat, publishers have started to retaliate by employing anti ad-blockers, which scout for ad-block users and react to them by pushing users to whitelist the website or disable ad-blockers altogether. The clash between ad-blockers and anti ad-blockers has resulted in a new arms race on the Web. In this paper, we present an automated machine learning based approach to identify anti ad-blockers that detect and react to ad-block users. The approach is promising with precision of 94.8% and recall of 93.1%. Our automated approach allows us to conduct a large-scale measurement study of anti ad-blockers on Alexa top-100K websites. We identify 686 websites that make visible changes to their page content in response to ad-block detection. We characterize the spectrum of different strategies used by anti ad-blockers. We find that a majority of publishers use fairly simple first-party anti ad-block scripts. However, we also note the use of third-party anti ad-block services that use more sophisticated tactics to detect and respond to ad-blockers.

  15. Phenomenology on a slice of AdS sub 5 xM supdelta spacetime

    CERN Document Server

    Davoudiasl, H; Hewett, J L

    2003-01-01

    We study the phenomenology resulting from backgrounds of the form AdS sub 5 xM supdelta, where M supdelta denotes a generic manifold of dimension subdelta>= 1, and AdS sub 5 is the slice of 5-dimensional anti-de Sitter space which generates the hierarchy in the Randall-Sundrum (RS) model. The delta additional dimensions may be required when the RS model is embedded into a more fundamental theory. We analyze two classes of delta-dimensional manifolds: flat and curved geometries. In the first case, the additional flat dimensions may accommodate localized fermions which in turn could resolve issues, such as proton decay and flavor, that were not addressed in the original RS proposal. In the latter case, the positive curvature of an S supdelta manifold with delta>1 can geometrically provide the 5-dimensional warping of the RS model. We demonstrate the key features of these two classes of models by presenting the background solutions, the spectra of the Kaluza-Klein (KK) gravitons, and their 4-dimensional coupling...

  16. Critical phenomena in higher curvature charged AdS black holes

    CERN Document Server

    Lala, Arindam

    2012-01-01

    In this paper we have studied the critical phenomena in higher curvature charged black holes in the anti-de Sitter (AdS) space-time. As an example we have considered the third order Lovelock-Born-Infeld black holes in AdS space-time. We have analytically derived the thermodynamic quantities of the system. Our analysis revealed the onset of a higher order phase transition in the black hole leading to an infinite discontinuity in the specific heat at constant charge at the critical points. Our entire analysis is based on the canonical framework where we have fixed the charge of the black hole. In an attempt to study the behavior of the thermodynamic quantities near the critical points we have derived the critical exponents of the system explicitly. Although the values of the critical points have been determined numerically, the critical exponents are calculated analytically. Our results fit well with the thermodynamic scaling laws. The scaling hypothesis is also seen to be consistent with these scaling laws. We...

  17. P-V criticality of AdS black holes in a general framework

    Science.gov (United States)

    Majhi, Bibhas Ranjan; Samanta, Saurav

    2017-10-01

    In black hole thermodynamics, it has been observed that AdS black holes behave as van der Waals system if one interprets the cosmological constant as a pressure term. Also the critical exponents for the phase transition of AdS black holes and the van der Waals systems are same. Till now this type of analysis is done by two steps. In the first step one shows that a particular metric allows phase transition and in the second step, using this information, one calculates the exponents. Here, we present a different approach based on two universal inputs (the general forms of the Smarr formula and the first law of thermodynamics) and one assumption regarding the existence of van der Waals like critical point for a metric. We find that the same values of the critical exponents can be obtained by this approach. Thus we demonstrate that, though the existence of van der Waals like phase transition depends on specific metrics, the values of critical exponents are then fixed for that set of metrics.

  18. P-V criticality of AdS black holes in a general framework

    Directory of Open Access Journals (Sweden)

    Bibhas Ranjan Majhi

    2017-10-01

    Full Text Available In black hole thermodynamics, it has been observed that AdS black holes behave as van der Waals system if one interprets the cosmological constant as a pressure term. Also the critical exponents for the phase transition of AdS black holes and the van der Waals systems are same. Till now this type of analysis is done by two steps. In the first step one shows that a particular metric allows phase transition and in the second step, using this information, one calculates the exponents. Here, we present a different approach based on two universal inputs (the general forms of the Smarr formula and the first law of thermodynamics and one assumption regarding the existence of van der Waals like critical point for a metric. We find that the same values of the critical exponents can be obtained by this approach. Thus we demonstrate that, though the existence of van der Waals like phase transition depends on specific metrics, the values of critical exponents are then fixed for that set of metrics.

  19. Proper temperature of the Schwarzschild AdS black hole revisited

    Science.gov (United States)

    Eune, Myungseok; Kim, Wontae

    2017-10-01

    The Unruh temperature calculated by using the global embedding of the Schwarzschild AdS spacetime into the Minkowski spacetime was identified with the local proper temperature; however, it became imaginary in a certain region outside the event horizon. So, the temperature was assumed to be zero of non-thermal radiation for that region. In this work, we revisit this issue in an exactly soluble two-dimensional Schwarzschild AdS black hole and present an alternative resolution to this problem in terms of the Tolman's procedure. However, the process appears to be non-trivial in the sense that the original procedure assuming the traceless energy-momentum tensor should be extended in such a way that it should cover the non-vanishing case of the energy-momentum tensor in the presence of the trace anomaly. Consequently, we show that the proper temperature turns out to be real everywhere outside the event horizon without any imaginary value, in particular, it vanishes at both the horizon and the asymptotic infinity.

  20. Covariant anomalies and Hawking radiation from Kaluza–Klein AdS ...

    Indian Academy of Sciences (India)

    The KK-AdS black hole considered is a non-extremal charged rotating solution in the theory of 4D gauged supergravity. Its Hawking fluxes of electric charge, angular momentum and energy momentum tensor are derived here. Our results support the common view that Hawking radiation is the quantum effect arising at the ...