Sample records for activation analysis principles

  1. In-vivo neutron activation analysis: principles and clinical applications

    Cohn, S.H.


    In vivo neutron activation has opened a new era of both clinical diagnosis and therapy evaluation, and investigation into and modelling of body composition. The techniques are new, but it is already clear that considerable strides can be made in increasing accuracy and precision, increasing the number of elements susceptible to measurement, enhancing uniformity, and reducing the dose required for the measurement. The work presently underway will yield significant data on a variety of environmental contaminants such as Cd. Compositional studies are determining the level of vital constituents such as nitrogen and potassium in both normal subjects and in patients with a variety of metabolic disorders. Therapeutic programs can be assessed while in progress. It seems likely that by the end of this century there will have been significant progress with this research tool, and exciting insights obtained into the nature and dynamics of human body composition.

  2. Principle Component Analysis of Birkeland Currents Determined by the Active Magnetosphere and Planetary Electrodynamics Response Experiment

    Milan, S. E.; Carter, J. A.; Korth, H.; Anderson, B. J.


    Principle Component Analysis is performed on northern and southern hemisphere Birkeland or field-aligned current (FAC) measurements from the Active Magnetosphere and Planetary Electrodynamics Response Experiment (AMPERE). PCA identifies the patterns in the FACs that respond coherently to different aspects of geomagnetic activity. The region 1 and 2 current system is shown to be the most reproducible feature of the currents, followed by cusp currents associated with magnetic tension forces on newly-reconnected field lines. The cusp currents are strongly modulated by season, indicating that their strength is regulated by the ionospheric conductance at the foot of the field lines. PCA does not identify a pattern that is clearly characteristic of a substorm current wedge. Rather, a superposed epoch analysis of the currents associated with substorms demonstrates that there is not a single mode of response, but a complicated and subtle mixture of different patterns. Other interhemispheric differences are discussed.

  3. Pharmaceutical gel analysis by NIR spectroscopy. Determination of the active principle and low concentration of preservatives.

    Blanco, M; Alcalá, M; Bautista, M


    Near infrared spectroscopy has proved highly suitable for the analysis of pharmaceutical formulations. However, its limited sensitivity can severely restrict its scope of application. In this work, we determine the active principle and two preservatives in a pharmaceutical preparation available as a hydrogel. The matrix of the pharmaceutical preparation exhibits strong absorption in the NIR spectral region; also, the two preservatives (parabens) are very similar in chemical and spectral terms, and present at low concentrations in the pharmaceutical. These complications make it rather difficult to accurately quantify the active principle and the preservatives, which can only be accomplished by using an effective design in order to prepare the samples to be included in the calibration set and select the optimum spectral range for measuring each analyte. The evaporation of solvents during the measurement process produces increasing errors related with sample's air exposition; the introductions of new samples with a wider range of the volatile components correct this effect. An ANOVA of the predictions obtained with the new models shows that correct the error due to evaporation. The proposed method was validated for the analytical control of the studied preparation.

  4. Principles of Fourier analysis

    Howell, Kenneth B


    Fourier analysis is one of the most useful and widely employed sets of tools for the engineer, the scientist, and the applied mathematician. As such, students and practitioners in these disciplines need a practical and mathematically solid introduction to its principles. They need straightforward verifications of its results and formulas, and they need clear indications of the limitations of those results and formulas.Principles of Fourier Analysis furnishes all this and more. It provides a comprehensive overview of the mathematical theory of Fourier analysis, including the development of Fourier series, "classical" Fourier transforms, generalized Fourier transforms and analysis, and the discrete theory. Much of the author''s development is strikingly different from typical presentations. His approach to defining the classical Fourier transform results in a much cleaner, more coherent theory that leads naturally to a starting point for the generalized theory. He also introduces a new generalized theory based ...

  5. Principles of harmonic analysis

    Deitmar, Anton


    This book offers a complete and streamlined treatment of the central principles of abelian harmonic analysis: Pontryagin duality, the Plancherel theorem and the Poisson summation formula, as well as their respective generalizations to non-abelian groups, including the Selberg trace formula. The principles are then applied to spectral analysis of Heisenberg manifolds and Riemann surfaces. This new edition contains a new chapter on p-adic and adelic groups, as well as a complementary section on direct and projective limits. Many of the supporting proofs have been revised and refined. The book is an excellent resource for graduate students who wish to learn and understand harmonic analysis and for researchers seeking to apply it.

  6. Principles of Language Learning Activity Design Based on Constructivism



    <正>This essay introduces constructivism and its four key theories in learning and explores its applications in language learning activity design.Following the theoretical background analysis,it proposes three principles concerning English language teaching activity design,namely interactive thinking principle,I + 1 principle and authentic communication principle.This paper also provides some practical teaching activities such as supporting examples of how these three principles can work in language teaching.

  7. The analysis of pricing principles at domestic industrial enterprises

    I.M. Rjabchenko


    Full Text Available The analysis of pricing principles at domestic industrial enterprisesTheoretical and methodological aspects of marketing pricing formation are investigated in the article. The aim of this research is systematization of marketing pricing principles and formation of corresponding offers concerning perfection of a domestic industrial enterprises pricing policy.The results of the analysis. The authors note that pricing principles are important element of pricing methodology which form basic positions, characteristics for all pricing system. The essence of such pricing principles as scientific substantiation of prices, target direction of prices, unity principle of pricing process, principle of continuous pricing process, interrelation between pricing policy and general enterprise strategy, principle of legality, planned character, proportionality, adequacy, principle of interdependence between types and forms of selling, flexibility principle is considered.The table of the resulted principles allows us to group them after the followings descriptions:general principles: planned character principle, principle of legality, principle of proportionality, principle of adequacy, principle of flexibility;main principles: principle of scientific prices substantiation, principle of prices target direction, unity principle of pricing process, principle of continuous pricing process;specific principles: principle of connection between pricing policy and general strategy of enterprise, principle of interrelation between types and forms of selling, principle connected with the features of products which will be distribute, principle connected with buyers quality maintenance;individual principles: principle connected with market structure, principle that applies to the choice of reaction type and market conditions change and so on.Conclusions and directions of further researches. Research of theoretical and methodological aspects of marketing pricing forming

  8. Principles-Driven Forensic Analysis

    Peisert, Sean; Bishop, Matt; Karin, Sidney; Marzullo, Keith


    It is possible to enhance our understanding of what has happened on a computer system by using forensic techniques that do not require prediction of the nature of the attack, the skill of the attacker, or the details of the system resources or objects affected. These techniques address five fundamental principles of computer forensics. These principles include recording data about the entire operating system, particularly user space events and environments, and interpreting events at differen...

  9. NEPR Principle Component Analysis - NOAA TIFF Image

    National Oceanic and Atmospheric Administration, Department of Commerce — This GeoTiff is a representation of seafloor topography in Northeast Puerto Rico derived from a bathymetry model with a principle component analysis (PCA). The area...

  10. Economic analysis of the principles of liability in tort in the backdrop of liability for compensation for damage occurring as a result of the activities of one entity to the goods of another entity

    Joanna Kuźmicka-Sulikowska


    Full Text Available The article addresses basic issues associated with the economic analysis of liability in tort principles. The deliberations focus on an attempt to define the economic and social consequences of introducing various combinations of principles of tortious liability for damage suffered as a result of the activities of one entity borne in the goods of another. Lack of liability situations are treated in some detail as well as liability based on the principle of risk and the principle of fault. The analyses were conducted based on unilateral and bilateral models. Factors coming into play in determining the economically effective level of carefulness in actions are discussed. A series of other factors of significant relevance for the choice of an optimal principle of liability from the economic point of view are also highlighted. In this context the role of the level of activity of entities, availability of insurance policies and costs associated with pursuing compensation claims are discussed. The deliberations are concluded with a summary, which also entails a critical look at the method of economic analysis of law.

  11. Simple Activity Demonstrates Wind Energy Principles

    Roman, Harry T.


    Wind energy is an exciting and clean energy option often described as the fastest-growing energy system on the planet. With some simple materials, teachers can easily demonstrate its key principles in their classroom. (Contains 1 figure and 2 tables.)

  12. Efficient and Effective Change Principles in Active Videogames.

    Straker, Leon M; Fenner, Ashley A; Howie, Erin K; Feltz, Deborah L; Gray, Cindy M; Lu, Amy Shirong; Mueller, Florian Floyd; Simons, Monique; Barnett, Lisa M


    Active videogames have the potential to enhance population levels of physical activity but have not been successful in achieving this aim to date. This article considers a range of principles that may be important to the design of effective and efficient active videogames from diverse discipline areas, including behavioral sciences (health behavior change, motor learning, and serious games), business production (marketing and sales), and technology engineering and design (human-computer interaction/ergonomics and flow). Both direct and indirect pathways to impact on population levels of habitual physical activity are proposed, along with the concept of a game use lifecycle. Examples of current active and sedentary electronic games are used to understand how such principles may be applied. Furthermore, limitations of the current usage of theoretical principles are discussed. A suggested list of principles for best practice in active videogame design is proposed along with suggested research ideas to inform practice to enhance physical activity.

  13. Active nondestructive assay of nuclear materials: principles and applications

    Gozani, Tsahi


    The purpose of this book is to present, coherently and comprehensively, the wealth of available but scattered information on the principles and applications of active nondestructive analysis (ANDA). Chapters are devoted to the following: background and overview; interactions of neutrons with matter; interactions of ..gamma..-rays with matter; neutron production and sources; ..gamma..-ray production and sources; effects of neutron and ..gamma..-ray transport in bulk media; signatures of neutron- and photon-induced fissions; neutron and photon detection systems and electronics; representative ANDA systems; and instrument analysis, calibration, and measurement control for ANDA. Each chapter has an introductory section describing the relationship of the topic of that chapter to ANDA. Each chapter ends with a section that summarizes the main results and conclusions of the chapter, and a reference list.

  14. When old principles face new challenges: a critical analysis of the principle of diplomatic inviolability


    This thesis aims to provide a comprehensive analysis of the principle of diplomatic inviolability. The principle of diplomatic inviolability is generally regarded by international law scholars as one of the oldest established principles of international law. The concept of inviolability in contemporary international law contains two distinct aspects: in terms of the duty of the receiving State, the first aspect involves the negative duty of not taking any enforcement action against the inviol...

  15. The principles of life-cycle analysis

    Hill, L.J.; Hunsaker, D.B.; Curlee, T.R.


    Decisionmakers representing government agencies must balance competing objectives when deciding on the purchase and sale of assets. The goal in all cases should be to make prudent or financially {open_quotes}cost-effective{close_quotes} decisions. That is, the revenues from the purchase or sale of assets should exceed any out-of-pocket costs to obtain the revenues. However, effects external to these financial considerations such as promoting environmental quality, creating or maintaining jobs, and abiding by existing regulations should also be considered in the decisionmaking process. In this paper, we outline the principles of life-cycle analysis (LCA), a framework that allows decisionmakers to make informed, balanced choices over the period of time affected by the decision, taking into account important external effects. Specifically, LCA contains three levels of analysis for any option: (1) direct financial benefits (revenues) and out-of-pocket costs for a course of action; (2) environmental and health consequences of a decision; and (3) other economic and socio-institutional effects. Because some of the components of LCA are difficult to value in monetary terms, the outcome of the LCA process is not generally a yes-no answer. However, the framework allows the decisionmaker to at least qualitatively consider all relevant factors in analyzing options, promoting sound decisionmaking in the process.

  16. Efficient and Effective Change Principles in Active Videogames

    Straker, Leon M; Fenner, Ashley A; Howie, Erin K; Feltz, Deborah L; Gray, Cindy M; Lu, Amy Shirong; Mueller, Florian Floyd; Simons, Monique; Barnett, Lisa M


    Active videogames have the potential to enhance population levels of physical activity but have not been successful in achieving this aim to date. This article considers a range of principles that may be important to the design of effective and efficient active videogames from diverse discipline are

  17. Guideline Principles for Designing Astronomy Activities

    Strubbe, Linda


    We astronomy outreachers are passionate about sharing astronomy widely-but many astronomy outreach activities are designed more by how we hope things will work than in a careful intentional way. We also rarely evaluate how well our activities are achieving our goals. As a result, many educational activities must be significantly less effective than they could be. Fortunately, there is a large body of education research on how people learn. If we are serious about sharing astronomy widely and effectively, we must treat our teaching like research: (1) Have clear goals for our outreach, evaluate how well we are achieving our goals, and revise our strategies in light of what we learn; and (2) Use appropriate teaching techniques supported by education research wherever possible.

  18. Vibrational optical activity principles and applications

    Nafie, Laurence A


    This unique book stands as the only comprehensive introduction to vibrational optical activity (VOA) and is the first single book that serves as a complete reference for this relatively new, but increasingly important area of molecular spectroscopy. Key features:A single-source reference on this topic that introduces, describes the background and foundation of this area of spectroscopy.Serves as a guide on how to use it to carry out applications with relevant problem solving.Depth and breadth of the subject is presented in a logical, complete and progressive fashion. A

  19. Mathematic principle of active jamming against wideband LFM radar

    Shixian Gong; Xizhang Wei; Xiang Li; Yongshun Ling


    The inherent mathematic principle of active jamming against the wideband linear frequency modulated (LFM) radar is investigated. According to different generation strategies, the active jamming methods are reclassified into three groups, i.e., non-coherent jamming (NCJ), convolution jamming (CJ) and mul-tiplying jamming (MJ). Based on the classification, the mathematic principles of different active jamming groups are put forward, which describe the relationships between the modulated signals and the jamming results. The advantages and disadvantages of different groups are further analyzed, which provides a new perspective for the study of jamming/anti-jamming methods and a potential for engineers to integrate similar jamming methods into one jam-mer platform. The analyses and simulation results of some typical active jamming methods prove the validity of the proposed mathe-matics principle.

  20. Proof-of-principle results for identifying the composition of dust particles and volcanic ash samples through the technique of photon activation analysis at the IAC

    Mamtimin, Mayir; Cole, Philip L.; Segebade, Christian


    Instrumental analytical methods are preferable in studying sub-milligram quantities of airborne particulates collected in dust filters. The multi-step analytical procedure used in treating samples through chemical separation can be quite complicated. Further, due to the minute masses of the airborne particulates collected on filters, such chemical treatment can easily lead to significant levels of contamination. Radio-analytical techniques, and in particular, activation analysis methods offer a far cleaner alternative. Activation methods require minimal sample preparation and provide sufficient sensitivity for detecting the vast majority of the elements throughout the periodic table. In this paper, we will give a general overview of the technique of photon activation analysis. We will show that by activating dust particles with 10- to 30-MeV bremsstrahlung photons, we can ascertain their elemental composition. The samples are embedded in dust-collection filters and are irradiated "as is" by these photons. The radioactivity of the photonuclear reaction products is measured with appropriate spectrometers and the respective analytes are quantified using multi-component calibration materials. We shall provide specific examples of identifying the elemental components of airborne dust particles and volcanic ash by making use of bremsstrahlung photons from an electron linear accelerator at the Idaho Accelerator Center in Pocatello, Idaho.

  1. A Tentative Analysis on Politeness Principles



    Different people hold different views about politeness in communication. To be polite, Leech thinks you should folow Politeness Principle(PP) while Levinson suggests paying attention to others' Face Wants. This paper attempts to shed light on some of the important application of PP in cultures.

  2. Application of Cooperative Principle in Discourse Analysis

    左改玲; 赵秋萍


    @@ 1.Introduction Cooperative Principle (CP) was first proposed by the U.S. linguist and philosopher Grice in the late 1960s. H.P. Grice lectures "Logic and Conversation" concept. "Logic and Conversation" points out that our conversation is subject to certain restricted conditions. Our talk exchanges do not normally consist of a succession of disconnected remarks, and would not be rational if they did. They are characteristically, to some degree at least.

  3. Principle analysis of IP wavelength router

    王勇; 殷洪玺; 徐安士; 吴德明


    Combining IP with WDM is an attractive direction for research. WDM will play an important role in IP network in future. Now, an urgent problem is how to introduce wavelength routing in an IP network. We solve this problem by designing IP wavelength router, implementing DPDP (default path and dedicated path) method. We prove the reasonableness and feasibility of this design by a principle experiment. A lot of problems related to this design are also discussed.

  4. Experimental analysis of the quantum complementarity principle

    Auccaise, R; Filgueiras, J G; Sarthour, R S; Oliveira, I S; Céleri, L C


    One of the milestones of quantum mechanics is Bohr's complementarity principle. It states that a single quantum can exhibit a particle-like \\emph{or} a wave-like behaviour, but never both at the same time. These are mutually exclusive and complementary aspects of the quantum system. This means that we need distinct experimental arrangements in order to measure the particle or the wave nature of a physical system. One of the most known representations of this principle is the single-photon Mach-Zehnder interferometer. When the interferometer is closed an interference pattern is observed (wave aspect of the quantum) while if it is open, the quantum behaves like a particle. Here, using a molecular quantum information processor and employing nuclear magnetic resonant (NMR) techniques, we analyze the quantum version of this principle by means of an interferometer that is in a quantum superposition of being closed and open, and confirm that we can indeed measure both aspects of the system with the same experimental...

  5. The Didactic Principles and Their Applications in the Didactic Activity

    Marius-Costel, Esi


    The evaluation and reevaluation of the fundamental didactic principles suppose the acceptance at the level of an instructive-educative activity of a new educational paradigm. Thus, its understanding implies an assumption at a conceptual-theoretical level of some approaches where the didactic aspects find their usefulness by relating to value…


    V.V. Morozov


    The strategy principles and main directions of regional investment activity financement mechanism improvement are formulated and worked out in the article. The contemporary conditions are analyzed, the factors are researched, the priority directions are defined, the suggestions on the better use of investment sources are worked out, and on this base the suggestions on the investment process activization in the territorial systems are worked out.

  7. Fundamental principles of the cultural-activity approach in the psychology of giftedness

    Babaeva, Yuliya D.


    Full Text Available This article examines the cultural-activity approach to the study of giftedness, which is based on the ideas of L. S. Vygotsky, A. N. Leontiev, and O. K. Tikhomirov. Three basic principles of this approach are described: the principle of polymorphism, the dynamic principle, and the principle of the holistic analysis of the giftedness phenomenon. The article introduces the results of empirical research (including a 10-year longitudinal study, which verifies the efficacy of the cultural-activity approach and its prospects for solving actual problems in the psychology of giftedness in light of the creation of new diagnostic procedures and methods of education and the development of gifted children.

  8. Principle-based concept analysis: Caring in nursing education

    Salehian, Maryam; Heydari, Abbas; Aghebati, Nahid; Moonaghi, Hossein Karimi; Mazloom, Seyed Reza


    Introduction The aim of this principle-based concept analysis was to analyze caring in nursing education and to explain the current state of the science based on epistemologic, pragmatic, linguistic, and logical philosophical principles. Methods A principle-based concept analysis method was used to analyze the nursing literature. The dataset included 46 English language studies, published from 2005 to 2014, and they were retrieved through PROQUEST, MEDLINE, CINAHL, ERIC, SCOPUS, and SID scientific databases. The key dimensions of the data were collected using a validated data-extraction sheet. The four principles of assessing pragmatic utility were used to analyze the data. The data were managed by using MAXQDA 10 software. Results The scientific literature that deals with caring in nursing education relies on implied meaning. Caring in nursing education refers to student-teacher interactions that are formed on the basis of human values and focused on the unique needs of the students (epistemological principle). The result of student-teacher interactions is the development of both the students and the teachers. Numerous applications of the concept of caring in nursing education are available in the literature (pragmatic principle). There is consistency in the meaning of the concept, as a central value of the faculty-student interaction (linguistic principle). Compared with other related concepts, such as “caring pedagogy,” “value-based education,” and “teaching excellence,” caring in nursing education does not have exact and clear conceptual boundaries (logic principle). Conclusion Caring in nursing education was identified as an approach to teaching and learning, and it is formed based on teacher-student interactions and sustainable human values. A greater understanding of the conceptual basis of caring in nursing education will improve the caring behaviors of teachers, create teaching-learning environments, and help experts in curriculum development

  9. Theoretical bases analysis of scientific prediction on marketing principles

    A.S. Rosohata


    Full Text Available The article presents an overview categorical apparatus of scientific predictions and theoretical foundations results of scientific forecasting. They are integral part of effective management of economic activities. The approaches to the prediction of scientists in different fields of Social science and the categories modification of scientific prediction, based on principles of marketing are proposed.

  10. Principles and Rules of Conduct in the Internal Audit Activity

    Mihaela Iuliana Dumitru


    Full Text Available The objectives of the paper are to present the basic principles governing the internal audit mission as well as the code of conduct that must be observed in exercising such a mission, because the completion of a professional audit mission implies precisely the compliance with the two category of elements. Consequently, this paper is meant to be added to the practice specific to this field as support in exercising the internal audit according to the market requirements. For this purpose, we analysed the above-mentioned elements, presenting brief examples in support of the importance of the approached topics. Thus, from the practical point of view, we can notice the mechanisms used to apply these principles and how the compliance with the audit specific audit conduct lead to a more efficient activity. For these reasons, we can say that the paper is an element of interest both for the academic field (as a starting point for the support of practical approaches and also for the future researches in order to improve the specific audit activity.

  11. Introducing Dynamic Analysis Using Malthus's Principle of Population.

    Pingle, Mark


    Declares the use of dynamic models is increasing in macroeconomics. Explains how to introduce dynamic models to students whose technical skills are modest or varied. Chooses Malthus's Principle of Population as a natural context for introducing dynamic analysis because it provides a method for reviewing the mathematical tools and theoretical…

  12. Safety of spanish nuclear park. Analysis of the fundamental principles of security of nuclear facilities and activities; Seguridad del parque nuclear espanol. Analisis de los principios fundamentales de ls seguridad de las instalaciones y actividades nucleares



    The aim of this study is to analyze the fundamental principles underlying the safety of nuclear installations and activities, which defined the International Atomic Energy Agency (IAEA). These principles determine the roles of government and responsibilities of the holders of power, explain how to achieve security and nuclear energy to justify the society, present and future and the environment from the risks of ionizing radiation, both and explain natural and man must be managed as waste that occur or have occurred in the past. (Author)

  13. Teaching Principles of One-Way Analysis of Variance Using M&M's Candy

    Schwartz, Todd A.


    I present an active learning classroom exercise illustrating essential principles of one-way analysis of variance (ANOVA) methods. The exercise is easily conducted by the instructor and is instructive (as well as enjoyable) for the students. This is conducive for demonstrating many theoretical and practical issues related to ANOVA and lends itself…

  14. 78 FR 64064 - Agency Information Collection (Principles of Excellence Complaint System Intake) Activity Under...


    ... AFFAIRS Agency Information Collection (Principles of Excellence Complaint System Intake) Activity Under... Excellence Complaint System Intake).'' SUPPLEMENTARY INFORMATION: Title: Principles of Excellence Complaint... System Intake) in any correspondence. FOR FURTHER INFORMATION CONTACT: Crystal Rennie, Enterprise...


    N. K. Chapaev


    Full Text Available The aim of the publication is a philosophical-pedagogical conceptualization and the discovery of the mechanism of application of the principle while solving problems of program-methodological support of vocational education on the basis of summarizing the scientific heritage of N. E. Jerganova.Methods. The research is based on the hermeneutic methodology. The leading methods of analysis are the following: interpretation, conceptualization, understanding, as well as analysis, comparing, contrasting, synthesis, generalization.Results. Based on the analysis of the texts of the works of N. E. Jerganova, interpretational model of actualization principle of activity in developing methods of professional education is developed. According to this model, personal and professional development of man is attained primarily due to the actualization of his/her intellectual and creative potential, turning it into relatively self-sufficient entity of educational activity.Scientific novelty. Philosophical-methodological foundations and technological tools of the application of the principle activities in the process of problem solving of software and methodological support of professional education are disclosed; the expediency of development of activity-based strategy of professional education in modern conditions is proved.Practical significance. The thesis and conclusions of the article can be used in the development of the modern concept of methodological activities, in the process of program-methodological support of educational activity in professional education organizations.

  16. Protein structure similarity from principle component correlation analysis

    Chou James


    Full Text Available Abstract Background Owing to rapid expansion of protein structure databases in recent years, methods of structure comparison are becoming increasingly effective and important in revealing novel information on functional properties of proteins and their roles in the grand scheme of evolutionary biology. Currently, the structural similarity between two proteins is measured by the root-mean-square-deviation (RMSD in their best-superimposed atomic coordinates. RMSD is the golden rule of measuring structural similarity when the structures are nearly identical; it, however, fails to detect the higher order topological similarities in proteins evolved into different shapes. We propose new algorithms for extracting geometrical invariants of proteins that can be effectively used to identify homologous protein structures or topologies in order to quantify both close and remote structural similarities. Results We measure structural similarity between proteins by correlating the principle components of their secondary structure interaction matrix. In our approach, the Principle Component Correlation (PCC analysis, a symmetric interaction matrix for a protein structure is constructed with relationship parameters between secondary elements that can take the form of distance, orientation, or other relevant structural invariants. When using a distance-based construction in the presence or absence of encoded N to C terminal sense, there are strong correlations between the principle components of interaction matrices of structurally or topologically similar proteins. Conclusion The PCC method is extensively tested for protein structures that belong to the same topological class but are significantly different by RMSD measure. The PCC analysis can also differentiate proteins having similar shapes but different topological arrangements. Additionally, we demonstrate that when using two independently defined interaction matrices, comparison of their maximum

  17. Student Engagement: A Principle-Based Concept Analysis.

    Bernard, Jean S


    A principle-based concept analysis of student engagement was used to examine the state of the science across disciplines. Four major perspectives of philosophy of science guided analysis and provided a framework for study of interrelationships and integration of conceptual components which then resulted in formulation of a theoretical definition. Findings revealed student engagement as a dynamic reiterative process marked by positive behavioral, cognitive, and affective elements exhibited in pursuit of deep learning. This process is influenced by a broader sociocultural environment bound by contextual preconditions of self-investment, motivation, and a valuing of learning. Outcomes of student engagement include satisfaction, sense of well-being, and personal development. Findings of this analysis prove relevant to nursing education as faculty transition from traditional teaching paradigms, incorporate learner-centered strategies, and adopt innovative pedagogical methodologies. It lends support for curricula reform, development of more accurate evaluative measures, and creation of meaningful teaching-learning environments within the discipline.

  18. Screening for antibacterial principle and activity of Aerva javanica (Burm .f) Juss. ex Schult.

    P Srinivas; S Ram Reddy


    Objective: To investigate the antibacterial principle and activity of Aerva javanica, a medicinal plant. Methods: Crude extracts of different parts of Aerva javanica were made with hexane, chloroform and methanol. Phytochemical analysis of the crude extracts was done by following the standard methodology, and antibacterial activity was evaluated by inhibition zone and MIC values. Crude extracts were resolved through HPTLC and the antibacterial activity of the separated compounds was evaluated by bioautography. Results: The yields of crude extracts made from different plant parts varied both with plant part and solvent. Methanolic extracts of leaf and flower have shown a wide range of phytochemicals and more antibacterial activity. HPTLC separation of extracts coupled with bioautography studies revealed that apigenin followed by rutin and kaempferol has shown antibacterial activity against more number of bacteria. Conclusions:The present study supports the use of Aerva javanica in the traditional medicine, and it can be used against bacterial infections.

  19. Principles of Micellar Electrokinetic Capillary Chromatography Applied in Pharmaceutical Analysis

    Árpád Gyéresi


    Full Text Available Since its introduction capillary electrophoresis has shown great potential in areas where electrophoretic techniques have rarely been used before, including here the analysis of pharmaceutical substances. The large majority of pharmaceutical substances are neutral from electrophoretic point of view, consequently separations by the classic capillary zone electrophoresis; where separation is based on the differences between the own electrophoretic mobilities of the analytes; are hard to achieve. Micellar electrokinetic capillary chromatography, a hybrid method that combines chromatographic and electrophoretic separation principles, extends the applicability of capillary electrophoretic methods to neutral analytes. In micellar electrokinetic capillary chromatography, surfactants are added to the buffer solution in concentration above their critical micellar concentrations, consequently micelles are formed; micelles that undergo electrophoretic migration like any other charged particle. The separation is based on the differential partitioning of an analyte between the two-phase system: the mobile aqueous phase and micellar pseudostationary phase. The present paper aims to summarize the basic aspects regarding separation principles and practical applications of micellar electrokinetic capillary chromatography, with particular attention to those relevant in pharmaceutical analysis.

  20. Principles of micellar electrokinetic capillary chromatography applied in pharmaceutical analysis.

    Hancu, Gabriel; Simon, Brigitta; Rusu, Aura; Mircia, Eleonora; Gyéresi, Arpád


    Since its introduction capillary electrophoresis has shown great potential in areas where electrophoretic techniques have rarely been used before, including here the analysis of pharmaceutical substances. The large majority of pharmaceutical substances are neutral from electrophoretic point of view, consequently separations by the classic capillary zone electrophoresis; where separation is based on the differences between the own electrophoretic mobilities of the analytes; are hard to achieve. Micellar electrokinetic capillary chromatography, a hybrid method that combines chromatographic and electrophoretic separation principles, extends the applicability of capillary electrophoretic methods to neutral analytes. In micellar electrokinetic capillary chromatography, surfactants are added to the buffer solution in concentration above their critical micellar concentrations, consequently micelles are formed; micelles that undergo electrophoretic migration like any other charged particle. The separation is based on the differential partitioning of an analyte between the two-phase system: the mobile aqueous phase and micellar pseudostationary phase. The present paper aims to summarize the basic aspects regarding separation principles and practical applications of micellar electrokinetic capillary chromatography, with particular attention to those relevant in pharmaceutical analysis.

  1. Microcalorimeter pulse analysis by means of principle component decomposition

    de Vries, C P; van der Kuur, J; Gottardi, L; Akamatsu, H


    The X-ray integral field unit for the Athena mission consists of a microcalorimeter transition edge sensor pixel array. Incoming photons generate pulses which are analyzed in terms of energy, in order to assemble the X-ray spectrum. Usually this is done by means of optimal filtering in either time or frequency domain. In this paper we investigate an alternative method by means of principle component analysis. This method attempts to find the main components of an orthogonal set of functions to describe the data. We show, based on simulations, what the influence of various instrumental effects is on this type of analysis. We compare analyses both in time and frequency domain. Finally we apply these analyses on real data, obtained via frequency domain multiplexing readout.

  2. Principles for microscale separations based on redox-active surfactants and electrochemical methods.

    Rosslee, C A; Abbott, N L


    We report principles for microscale separations based on selective solubilization and deposition of sparingly water-soluble compounds by an aqueous solution of a redox-active surfactant. The surfactant, (11-ferrocenylundecyl)trimethylammonium bromide, undergoes a reversible change in micellization upon oxidation or reduction. This change in aggregation is exploited in a general scheme in which micelles of reduced surfactant are formed and then put in contact with a mixture of hydrophobic compounds leading to selective solubilization of the compounds. The micelles are then electrochemically disrupted, leading to the selective deposition of their contents. We measured the selectivity of the solubilization and deposition processes using mixtures of two model drug-like compounds, o-tolueneazo-beta-naphthol (I) and 1-phenylazo-2-naphthylamine (II). By repeatedly solubilizing and depositing a mixture that initially contained equal mole fractions of each compound, we demonstrate formation of a product that contains 98.4% of I after six cycles. Because the aggregation states of redox-active surfactants are easily controlled within simple microfabricated structures, including structures that define small stationary volumes (e.g., wells of a microtiter plate) or flowing volumes of liquids (e.g., microfabricated channels), we believe these principles may be useful for the purification or analysis of compounds in microscale chemical process systems. When used for purification, these principles provide separation of surfactant and product.

  3. Wear Debris Analysis:Fundamental Principle of Wear-Graphy

    陈铭; 王伟华; 殷勇辉; 王成焘


    A new wear-graphy technology was developed, which can simultaneously identify the shape and composition of wear debris, for both metals and non-metals.The fundamental principles of the wear-graphy system and its wear-gram system are discussed here.A method was developed to distribute wear debris on a slide uniformly to reduce overlapping of wear debris while smearing.The composition identification analyzes the wear debris using the scanning electron microscope (SEM) energy spectrum, infrared-thermal imaging and X-ray imaging technology.A wear debris analysis system based on database techniques is demonstrated, and a visible digitized wear-gram is acquired based on the information of wear debris with image collection and processing of the wear debris.The method gives the morphological characteristics of the wear debris, material composition identification of the wear debris, intelligent recognition of the wear debris, and storage and management of wear debris information.

  4. Antimicrobial effect of Calotropis procera active principles against aquatic microbial pathogens isolated from shrimp and fishes

    Subramanian Velmurugan; Vijayaragavan Thanga Viji; Mariavincent Michael Babu; Mary Josephine Punitha; Thavasimuthu Citarasu


    Objective: To study the influence of Calotropis procera (C. procera) active principles against aquatic microbial pathogens isolated from shrimp and fishes. Methods: C. procera leaf powder was serially extracted with hexane, ethyl acetate and methanol and screened by antibacterial, antifungal and antiviral activity against aquatic pathogens which isolated from shrimp/fish. After initial screening, the active extract was purified through column chromatography and again screened. Finally the active fractions were characterized by phytochemical analysis and GC-MS analysis. Results: In vitro antibacterial, antifungal and antiviral screening revealed that, the ethyl acetate extracts were effectively suppressed the bacterial pathogens Pseudomonas aeruginosa (P. aeruginosa), Vibrio harveyi (V. harveyi) and Aeromons hydrophila (A. hydrophila) of more than 20 mm zone of inhibition; the fungi Fusarium sp and the killer virus WSSV. The ethyl acetate extracts of C. procera incubated WSSV was failed to multiply its progeny in the in vivo system of shrimp P. monodon. The shrimp had 80% survival after WSSV challenge from the control group significantly (P<0.001) and also PCR detection confirmed that no WSSV transcription found in shrimp haemolymph. After purified the ethyl acetate extracts again antimicrobial screening performed and it concluded that the fraction namely F-II was effectively suppressed the bacterial growth and WSSV due to its enriched active principles such as cardiac glycosides, Phenols, alkaloids, Tannin and quinines. Surprisingly this fraction, F-II was effectively controlled the WSSV at 90% level at a highest significant level (P<0.001). Finally the structural characterization by GC-MS analysis revealed that, the F-II fraction contained Phenols including several other compounds such as 2,4-bis(1,1-dimethylethyl)-, Methyl tetradecanoate, Bicyclo[3.1.1] heptane, 2,6,6-trimethyl-, (1α,2β,5α)-and Hexadecanoic acid etc. Conclusions: The present study revealed

  5. Salvia officinalis for hot flushes: towards determination of mechanism of activity and active principles.

    Rahte, Sinikka; Evans, Richard; Eugster, Philippe J; Marcourt, Laurence; Wolfender, Jean-Luc; Kortenkamp, Andreas; Tasdemir, Deniz


    Herbal medicinal products are commonly used in alternative treatment of menopausal hot flushes. In a recent clinical study, Salvia officinalis tincture was found to reduce hot flush frequency and intensity. The aim of the current study was the investigation of the mechanism(s) responsible for the anti-hot flush activity of S. officinalis and determination of its active principle(s). The 66% ethanolic tincture, as well as the n-hexane, CHCl₃, and aqueous ethanolic subextracts obtained from the tincture were studied in vitro for two of the most relevant activities, estrogenicity and selective serotonin reuptake inhibition. Because of an increased risk of menopausal women to suffer from Alzheimer's disease, an in vitro acetylcholinesterase inhibition assay was also employed. No activity was observed in the selective serotonin reuptake inhibition or the acetylcholinesterase inhibition assays at the highest test concentrations. The tincture showed no estrogenic effects whereas the aqueous ethanolic subextract exhibited estrogenicity in the ERLUX assay with an EC₅₀ value of 64 µg/mL. Estrogenic activity-guided fractionation of the aqueous ethanolic subextract by a combination of reverse-phase vacuum liquid chromatography and gel chromatography identified luteolin-7-O-glucuronide (EC₅₀ 129 µg/mL) as the active component of the vacuum liquid chromatography fraction 4 (EC₅₀ 69 µg/mL). Luteolin-7-O-glucoside was identified as the putative estrogenic principle of the most potent minor fraction (, EC₅₀ 0.7 µg/mL) obtained from the initial vacuum liquid chromatography fraction 7 (EC₅₀ 3 µg/mL). This study suggests the involvement of common and ubiquitous estrogenic flavonoids in the anti-hot flush effect of Salvia officinalis, a safe and commonly used herbal medicinal product during the menopause.

  6. Neutron Activation Analysis of Water - A Review

    Buchanan, John D.


    Recent developments in this field are emphasized. After a brief review of basic principles, topics discussed include sources of neutrons, pre-irradiation physical and chemical treatment of samples, neutron capture and gamma-ray analysis, and selected applications. Applications of neutron activation analysis of water have increased rapidly within the last few years and may be expected to increase in the future.

  7. Analysis on Phase Transformation (ATP) Using Computational Thermal Principles (CTP)

    N.Alagurmurthi; K.Palaniradja; V. Soundararajan


    Computer analysis based on computational thermal principles to predict the transformation kinetics in steels at varying temperatures is of great practical importance in different areas of heat treatment. As a result, using the theory of transient state heat conduction with convective boundary conditions, an efficient program named "ATP" (Analysis on Phase Transformation) has been developed to determine the temperature distribution under different quenching conditions for different geometries such as plate, cylinder and sphere. In addition to these the microstructures and the corresponding hardness developed during quenching are predicted using Time Temperature Transformation (TTT) diagram incorporated in the analysis. To approve our work, dilation curves, Heisler charts and time-temperature history curve have been generated. This paper deals with basic objective of the program (ATP) determination of temperature, microstructure and hardness distribution and also includes an online prediction of austenite-pearlite and austenite-martensite transformation in steels along with the corresponding retained fractions. The quenching of a cylinder in gases, liquids and liquid metals is analyzed to show the non-liner effect of cylinder diameter on the temperature and microstructures. Further in the program we have considered a typical 1080 steel cylinders quenched in water for predicting and comparing the program results with experimental values and can be extended even to other grades of steels. The numerical results of program are found to be in good agreement with the experimental data obtained. Finally the quenching process analysis described in the study appears to be a promising tool for the design of heat-treatment process parameters for steels.

  8. Prediction of solid oxide fuel cell cathode activity with first-principles descriptors

    Lee, Yueh-Lin; Kleis, Jesper; Rossmeisl, Jan


    In this work we demonstrate that the experimentally measured area specific resistance and oxygen surface exchange of solid oxide fuel cell cathode perovskites are strongly correlated with the first-principles calculated oxygen p-band center and vacancy formation energy. These quantities...... are therefore descriptors of catalytic activity that can be used in the first-principles design of new SOFC cathodes....

  9. Mathematical principles of signal processing Fourier and wavelet analysis

    Brémaud, Pierre


    Fourier analysis is one of the most useful tools in many applied sciences. The recent developments of wavelet analysis indicates that in spite of its long history and well-established applications, the field is still one of active research. This text bridges the gap between engineering and mathematics, providing a rigorously mathematical introduction of Fourier analysis, wavelet analysis and related mathematical methods, while emphasizing their uses in signal processing and other applications in communications engineering. The interplay between Fourier series and Fourier transforms is at the heart of signal processing, which is couched most naturally in terms of the Dirac delta function and Lebesgue integrals. The exposition is organized into four parts. The first is a discussion of one-dimensional Fourier theory, including the classical results on convergence and the Poisson sum formula. The second part is devoted to the mathematical foundations of signal processing - sampling, filtering, digital signal proc...

  10. First principle active neutron coincidence counting measurements of uranium oxide

    Goddard, Braden; Charlton, William; Peerani, Paolo


    Uranium is present in most nuclear fuel cycle facilities ranging from uranium mines, enrichment plants, fuel fabrication facilities, nuclear reactors, and reprocessing plants. The isotopic, chemical, and geometric composition of uranium can vary significantly between these facilities, depending on the application and type of facility. Examples of this variation are: enrichments varying from depleted (~0.2 wt% 235U) to high enriched (>20 wt% 235U); compositions consisting of U3O8, UO2, UF6, metallic, and ceramic forms; geometries ranging from plates, cans, and rods; and masses which can range from a 500 kg fuel assembly down to a few grams fuel pellet. Since 235U is a fissile material, it is routinely safeguarded in these facilities. Current techniques for quantifying the 235U mass in a sample include neutron coincidence counting. One of the main disadvantages of this technique is that it requires a known standard of representative geometry and composition for calibration, which opens up a pathway for potential erroneous declarations by the State and reduces the effectiveness of safeguards. In order to address this weakness, the authors have developed a neutron coincidence counting technique which uses the first principle point-model developed by Boehnel instead of the "known standard" method. This technique was primarily tested through simulations of 1000 g U3O8 samples using the Monte Carlo N-Particle eXtended (MCNPX) code. The results of these simulations showed good agreement between the simulated and exact 235U sample masses.

  11. Thermodynamic principles governing metabolic operation : inference, analysis, and prediction

    Niebel, Bastian


    The principles governing metabolic flux are poorly understood. Because diverse organisms show similar metabolic flux patterns, we hypothesized that fundamental thermodynamic constraints might shape cellular metabolism. We developed a constraint-based model for Saccharomyces cerevisiae that included

  12. A Brief Analysis of Translation Principles in English Advertisements



    Advertising English, as an application language, has become universal and dependent. In this thesis, the author summarizes 3 translation principles in English advertisements, which provide the reference to the advertising translation.

  13. Modeling & imaging of bioelectrical activity principles and applications

    He, Bin


    Over the past several decades, much progress has been made in understanding the mechanisms of electrical activity in biological tissues and systems, and for developing non-invasive functional imaging technologies to aid clinical diagnosis of dysfunction in the human body. The book will provide full basic coverage of the fundamentals of modeling of electrical activity in various human organs, such as heart and brain. It will include details of bioelectromagnetic measurements and source imaging technologies, as well as biomedical applications. The book will review the latest trends in

  14. Active-involvement principle in dental health education

    Schou, L


    A basic problem in dental health education (DHE) is that the effect usually disappears shortly after the termination of a program. The purpose of the present study was to obtain long-term effect of a DHE-program by emphasizing the active involvement of the participants. The sample comprised...

  15. Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles

    Robin Mesnage


    Full Text Available Pesticides are used throughout the world as mixtures called formulations. They contain adjuvants, which are often kept confidential and are called inerts by the manufacturing companies, plus a declared active principle, which is usually tested alone. We tested the toxicity of 9 pesticides, comparing active principles and their formulations, on three human cell lines (HepG2, HEK293, and JEG3. Glyphosate, isoproturon, fluroxypyr, pirimicarb, imidacloprid, acetamiprid, tebuconazole, epoxiconazole, and prochloraz constitute, respectively, the active principles of 3 major herbicides, 3 insecticides, and 3 fungicides. We measured mitochondrial activities, membrane degradations, and caspases 3/7 activities. Fungicides were the most toxic from concentrations 300–600 times lower than agricultural dilutions, followed by herbicides and then insecticides, with very similar profiles in all cell types. Despite its relatively benign reputation, Roundup was among the most toxic herbicides and insecticides tested. Most importantly, 8 formulations out of 9 were up to one thousand times more toxic than their active principles. Our results challenge the relevance of the acceptable daily intake for pesticides because this norm is calculated from the toxicity of the active principle alone. Chronic tests on pesticides may not reflect relevant environmental exposures if only one ingredient of these mixtures is tested alone.

  16. Prompt gamma-ray activation analysis (PGAA)

    Kern, J. [Fribourg Univ. (Switzerland). Inst. de Physique


    The paper deals with a brief description of the principles of prompt gamma-ray activation analysis (PGAA), with the detection of gamma-rays, the PGAA project at SINQ and with the expected performances. 8 figs., 3 tabs., 10 refs.

  17. Analysis of the optimality principles responsible for vascular network architectonics

    Lubashevsky, I A


    The equivalence of two optimality principles leading to Murray's law has been discussed. The first approach is based on minimization of biological work needed for maintaining the blood flow through the vessels at required level. The second one is the principle of minimal drag and lumen volume. Characteristic features of these principles are considered. An alternative approach leading to Murray's law has been proposed. For that we model the microcirculatory bed in terms of delivering vascular network with symmetrical bifurcation nodes, embedded uniformly into the cellular tissue. It was shown that Murray's law can be regarded as a direct consequence of the organism capacity for controlling the blood flow redistribution over the microcirculatory beds.

  18. Design principles for data- and change-oriented organisational analysis in workplace health promotion.

    Inauen, A; Jenny, G J; Bauer, G F


    This article focuses on organizational analysis in workplace health promotion (WHP) projects. It shows how this analysis can be designed such that it provides rational data relevant to the further context-specific and goal-oriented planning of WHP and equally supports individual and organizational change processes implied by WHP. Design principles for organizational analysis were developed on the basis of a narrative review of the guiding principles of WHP interventions and organizational change as well as the scientific principles of data collection. Further, the practical experience of WHP consultants who routinely conduct organizational analysis was considered. This resulted in a framework with data-oriented and change-oriented design principles, addressing the following elements of organizational analysis in WHP: planning the overall procedure, data content, data-collection methods and information processing. Overall, the data-oriented design principles aim to produce valid, reliable and representative data, whereas the change-oriented design principles aim to promote motivation, coherence and a capacity for self-analysis. We expect that the simultaneous consideration of data- and change-oriented design principles for organizational analysis will strongly support the WHP process. We finally illustrate the applicability of the design principles to health promotion within a WHP case study.

  19. An Analysis of the Economy Principle Applied in Cyber Language



    With the development of network technology,cyber language,a new social dialect,is widely used in our life.The author analyzes how the economy principle is applied in cyber language from three aspects—word-formation,syntax and non-linguistic symbol.And the author collects,summarizes and analyzes the relevant language materials to prove the economy principle’s real existence in chat room and the reason why the economy principle is applied widely in cyber space.

  20. Principles of Quantitative Estimation of the Chaperone-Like Activity


    Molecular chaperones are able to interact with unfolded states of the protein molecule preventing their aggregation and facilitating folding of the polypeptide chain into the native structure. An understanding of the mechanism of protein aggregation is required to estimate the efficiency of action of chaperones in the test-systems based on the suppression of aggregation of protein substrates. The kinetic regimes of aggregation of proteins are discussed. The analysis of the aggregation kinetics of proteins shows that after passing the lag phase, aggregation follows, as a rule, first order kinetics. The quantitative characterization methods of the ability of chaperones to prevent aggregation of protein substrates have been elaborated.



    Sampling principle and characteristics and edge effect of orthogonal wavelet transform of signals are researched. Two samples of signals and wavelet bases must be taken in wavelet transform. In the second sample sampling interval or sampling length in different frequency range will be automatically adjusted. Wavelet transform can detect singular points. Both ends of signals are singular points. Edge effect is not avoidable.

  2. Science Curricula Design: Analysis of Authors' Ideological and Pedagogical Principles

    Ferreira, Silvia; Morais, Ana M.; Neves, Isabel P.


    The study analyses the extent to which the sociological message transmitted by the Official Pedagogic Discourse of the curriculum for Portuguese middle schools contains the ideological and pedagogical principles of its authors. The research is epistemologically and sociologically grounded, placing particular emphasis on Bernstein theory of…

  3. Analysis of School Food Safety Programs Based on HACCP Principles

    Roberts, Kevin R.; Sauer, Kevin; Sneed, Jeannie; Kwon, Junehee; Olds, David; Cole, Kerri; Shanklin, Carol


    Purpose/Objectives: The purpose of this study was to determine how school districts have implemented food safety programs based on HACCP principles. Specific objectives included: (1) Evaluate how schools are implementing components of food safety programs; and (2) Determine foodservice employees food-handling practices related to food safety.…


    Mironchuk V. A.


    Full Text Available The article provides and justifies the most preferred principle of innovative activity in agro-industrial complex - the development of multilevel model based on marketing concept of spheres and its approaches to managing innovation. The concept aims to create a competitive scientific and technical production, demand in the market through active marketing of the scientific-technical and innovation industry

  5. Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction.

    El-Shemy, H A; Aboul-Soud, M A M; Nassr-Allah, A A; Aboul-Enein, K M; Kabash, A; Yagi, A


    The aim of this study was to evaluate the potential anticancer properties and modulatory effect of selected Aloe vera (A. vera) active principles on antioxidant enzyme activities. Thus, three anthraquinones (Namely: aloesin, aloe-emodin and barbaloin) were extracted from A. vera leaves by supercritical fluid extraction and subsequently purified by high performance liquid chromatography. Additionally, the N-terminal octapeptide derived from verectin, a biologically active 14 kDa glycoprotein present in A. vera, was also tested. In vivo, active principles exhibited significant prolongation of the life span of tumor-transplanted animals in the following order: barbaloin> octapeptide> aloesin > aloe-emodin. A. vera active principles exhibited significant inhibition on Ehrlich ascite carcinoma cell (EACC) number, when compared to positive control group, in the following order: barbaloin> aloe-emodin > octapeptide > aloesin. Moreover, in trypan blue cell viability assay, active principles showed a significant concentration-dependent cytotoxicity against acute myeloid leukemia (AML) and acute lymphocytes leukemia (ALL) cancerous cells. Furthermore, in MTT cell viability test, aloe-emodin was found to be active against two human colon cancer cell lines (i.e. DLD-1 and HT2), with IC(50) values of 8.94 and 10.78 microM, respectively. Treatments of human AML leukemic cells with active principles (100 microg ml(-1)) resulted in varying intensities of internucleosomal DNA fragmentation, hallmark of cells undergoing apoptosis, in the following order: aloe-emodin> aloesin> barbaloin> octapeptide. Intererstingly, treatment of EACC tumors with active principles resulted in a significant elevation activity of key antioxidant enzymes (SOD, GST, tGPx, and LDH). Our data suggest that the tested A. vera compounds may exert their chemo-preventive effect through modulating antioxidant and detoxification enzyme activity levels, as they are one of the indicators of tumorigenesis. These

  6. [Analysis of efficiency of human sleep by Pareto principle].

    Verbitskiĭ, E V; Grachev, G A


    The results of system assessment efficiency of human night sleep which was registered on a large number of people without health problems, and data on the modeling of sleep structure by Pareto principle were showed. In contrast to the assessment of sleep efficiency, as the ratio of the duration of electrophysiological sleep to the total time of sleep, the introduced method increase adequacy assessment by taking into gender factor in the somnology and personalized medicine.

  7. Alanna Conners and the Origins of Principled Data Analysis

    Scargle, Jeffrey D.


    Alanna was one of the most important pioneers in the development of not just sophisticated algorithms for analyzing astronomical data but more importantly an overall viewpoint emphasizing the use of statistically sound principles in place of blind application of cook-book recipes, or black boxes. I will outline some of the threads of this viewpoint, emphasizing time series data, with a focus on the importance of these developments for the Age of Digital Astronomy that we are entering.

  8. An Analysis of Yusuf (AS's Counter-Cyclical Principle and its Implementation in the Modern World

    Jameel Ahmed


    Full Text Available Objective - This study examines the present-day implementation of the counter-cyclical principle suggested by Yusuf (AS around four thousand years ago, in response to the King of Egypt's dream, to overcome the famine of seven years through saving grain during seven years of abundance. In general, the counter-cyclical principle encourages saving during times of plenty and spending during times of scarcity, activities which today help to stabilise the business-cycle.Method - Library research is applied since this paper relies on secondary data by thoroughly reviewing the most relevant literature. This paper reviews the commodity-based currency systems proposed before, during and after the Second World War by several prominent economists (particularly Keynes, 1938; Graham, 1940; Hayek, 1943; Grondona, 1950 and Lietaer, 2001 all of which basically incorporated the counter-cyclical principle of Prophet Yusuf (AS. The primary purpose of these commodity-based currency systems is to stabilise the real value of money in order to improve macroeconomic stability. Additionally, this paper provides an in-depth analysis of Grondona system of conditional currency convertibility.Results - The Grondona system would partially stabilise the real value of each country's national currency in terms of a range of durable, essential, basic imported commodities, thereby also partially stabilising the prices of the selected commodities in terms of the national currency of each country implementing the system.Conclusion - The Grondona system of conditional currency convertibility as compared to other commodity-based currency systems is more practical. Its primary advantage in comparison to other proposals of commodity reserve currency is that it could be implemented in parallel with the existing monetary system. Accordingly, it could be taken as a preliminary step towards a monetary system based on real money such as gold dinar.Keywords : Counter-cyclical principle

  9. Concepts and principles in the analysis of brain networks.

    Wig, Gagan S; Schlaggar, Bradley L; Petersen, Steven E


    The brain is a large-scale network, operating at multiple levels of information processing ranging from neurons, to local circuits, to systems of brain areas. Recent advances in the mathematics of graph theory have provided tools with which to study networks. These tools can be employed to understand how the brain's behavioral repertoire is mediated by the interactions of objects of information processing. Within the graph-theoretic framework, networks are defined by independent objects (nodes) and the relationships shared between them (edges). Importantly, the accurate incorporation of graph theory into the study of brain networks mandates careful consideration of the assumptions, constraints, and principles of both the mathematics and the underlying neurobiology. This review focuses on understanding these principles and how they guide what constitutes a brain network and its elements, specifically focusing on resting-state correlations in humans. We argue that approaches that fail to take the principles of graph theory into consideration and do not reflect the underlying neurobiological properties of the brain will likely mischaracterize brain network structure and function.

  10. Embarrassment as a key to understanding cultural differences. Basic principles of cultural analysis

    Bouchet, Dominique


    I introduce here the principles I use in my investigation of intercultural marketing and management. I explain how I discovered them, and show how they spring from a theoretical understanding of the dynamic of cultural differences. One of the basic methodological principles for my analysis...

  11. Evaluation of Antileishmanial Activity of Selected Brazilian Plants and Identification of the Active Principles

    Valdir Cechinel Filho


    Full Text Available This study evaluated extracts, fractions, and isolated compounds from some selected Brazilian medicinal plants against strains of promastigotes of Leishmania amazonensis and L. brasiliensis in vitro. The cell viability was determined, comparing the results with reference standards. The dichloromethane fractions of the roots, stems, and leaves of Allamanda schottii showed IC50 values between 14.0 and 2.0 μg/mL. Plumericin was the main active compound, with IC50 of 0.3 and 0.04 μg/mL against the two species of Leishmania analyzed. The hexane extract of Eugenia umbelliflora fruits showed IC50 of 14.3 and 5.7 μg/mL against L. amazonensis and L. brasiliensis, respectively. The methanolic extracts of the seeds of Garcinia achachairu and guttiferone A presented IC50 values of 35.9 and 10.4 μg/mL, against L. amazonensis, respectively. The ethanolic extracts of the stem barks of Rapanea ferruginea and the isolated compound, myrsinoic acid B, presented activity against L. brasiliensis with IC50 of 24.1 and 6.1 μg/mL. Chloroform fraction of Solanum sisymbriifolium exhibited IC50 of 33.8 and 20.5 μg/mL, and cilistol A was the main active principle, with IC50 of 6.6 and 3.1 μg/mL against L. amazonensis and L. brasiliensis, respectively. It is concluded that the analyzed plants are promising as new and effective antiparasitic agents.

  12. Did Osler suffer from "paranoia antitherapeuticum baltimorensis"?: A comparative content analysis of The Principles and Practice of Medicine and Harrison's Principles of Internal Medicine, 11th edition


    One of the most important legacies of Sir William Osler was his textbook The Principles and Practice of Medicine. A common criticism of the book when it was first published was its deficiency in the area of therapeutics. In this article, the 1st edition of The Principles and Practice of Medicine is compared with the 11th edition of Harrison's Principles of Internal Medicine. The analysis focuses on the treatment recommendations for 4 conditions that were covered in both books (diabetes mellit...

  13. Northeast Puerto Rico and Culebra Island Principle Component Analysis - NOAA TIFF Image

    National Oceanic and Atmospheric Administration, Department of Commerce — This GeoTiff is a representation of seafloor topography in Northeast Puerto Rico derived from a bathymetry model with a principle component analysis (PCA). The area...

  14. Activity-Based Management principles and implementation opportunities of the ABM system

    Căpuşneanu, Sorinel/I


    This article describes the principles of Activity-Based Management and treats the implementation stages of it in enterprises from steel industry of Romania. The ABC method becomes the main tool of providing information for the ABM method. Thus, the ABM method becomes an important tool of obtaining performances in business.

  15. Principles and Implementation of Reading Activities in Primary School English Class

    Jinxiu, Jing; Zhengping, Zeng


    Reading is an important skill in learning English. However, reading class is not emphasized in some primary schools in China, and there are various problems with the reading activities, which inadequately just focus on teaching of words, sentences separately from texts. This paper aims to bring out a whole system of principles in designing…

  16. Modeling Hurricanes using Principle Component Analysis in conjunction with Non-Response Analysis

    Wooten, Rebecca D


    This paper demonstrates how principle component analysis can be used to determine the distinct factors that house the terms that explain the variance among the co-dependent variables and how non-response analysis can be applied to model the non-functional relationship that exist in a dynamic system. Moreover, the analysis indicates that there are pumping actions or ebb and flow between the pressure and the water temperature readings near the surface of the water days before a tropical storm forms in the Atlantic Basin and that there is a high correlation between storm conditions and buoy conditions three-four days before a storm forms. Further analysis shows that that the relationship among the variables is conical.

  17. Three-way component analysis : Principles and illustrative application

    Kiers, Henk A.L.; Van Mechelen, Iven


    Three-way component analysis techniques are designed for descriptive analysis of 3-way data, for example, when data are collected on individuals, in different settings, and on different measures. Such techniques summarize all information in a 3-way data set by summarizing, for each way of the 3-way

  18. New Forestry Principles from Ecosystem Analysis of Pacific Northwest Forests.

    Swanson, F J; Franklin, J F


    Forest management practices on Federal lands in the Pacific Northwest of the United States have been the center of intense controversy. Conflicting value systems, new information, and new perspectives have fueled the debate over the balance between timber production and preservation of natural ecosystems. In this paper we consider examples from three aspects of forest management: (1) management of forest stands, (2) management of the patchwork of forest stands at the landscape scale, and (3) management of streams and riparian networks. In each of these cases we examine: management practices and perspectives of the recent past, findings from ecosystem research that are leading to change in those practices, resulting changes in management practices, and future research directions. We also suggest a path for future change, including systems for managing in the face of uncertainty. Results of research in natural and managed forest and stream ecosystems have been pivotal in reassessment and redesign of management practices to provide a broader range of management options for society to consider. Results of studies of natural disturbance processes and their effects are used as reference points for management systems intending to sustain biological diversity and ecosystem productivity. Stand management practices, for example, are being modified to retain some live trees and greater amounts of dead woody debris, both standing and down, in areas that would instead be clear-cut under intensive plantation forestry practices. The motivations for these modified practices are to sustain biological diversity, including key wildlife species, and to maintain soil productivity. Models of alternative forest-cutting patterns at a landscape scale are being used to examine their effects on ecosystem structure and function. One result of this analysis has been to shift from the previous system of dispersing cutting units to a system involving greater aggregation of units using designs to

  19. Principles of Micellar Electrokinetic Capillary Chromatography Applied in Pharmaceutical Analysis

    Árpád Gyéresi; Eleonora Mircia; Brigitta Simon; Aura Rusu; Gabriel Hancu


    Since its introduction capillary electrophoresis has shown great potential in areas where electrophoretic techniques have rarely been used before, including here the analysis of pharmaceutical substances. The large majority of pharmaceutical substances are neutral from electrophoretic point of view, consequently separations by the classic capillary zone electrophoresis; where separation is based on the differences between the own electrophoretic mobilities of the analytes; are hard to achieve...

  20. The juridical nature of the European Court of Justice and the principles of its activity

    Vilma Hasneziri


    In this work, especially in the second part, there shall be presented several decisions of the European Court of Justice as well, that have to do with its interpretation on the dispositions of the establishing Treaties as well as the analysis of the above mentioned principles. At the end of this work, there will be given its conclusions as well as the bibliography where it is based on.

  1. On the neglect of causality principles in solar activity - climate relations.

    Stauning, Peter


    Many research papers have claimed to demonstrate close relations between solar activity and the terrestrial climate. In most cases the relations have been based on comparisons between time series of solar activity parameters, for instance sunspot numbers, and climate parameters, for instance terrestrial temperatures. However, many of the reported close relations are based on skilfully manipulated data and neglect of basic causality principles. For cause-effect relations to be reliably established, the cause must obviously happen prior to the effects. Thus it is problematic to use, for instance, running averages of parameters if the result depends too much on posterior elements of the causative time series or precursory elements of the effects. Even more neglected are the causality principles for cause-effect relations with a strongly varying source function. Damping of source variations by smoothing data handling introduces additional implied delays, which should be considered in the judgement of apparent correlations between processed time series of cause and effect parameters. The presentation will discuss examples of frequently quoted solar activity-climate relations (e.g., by Reid, Friis-Christensen, and Svensmark), which violate basic causality principles.

  2. Quality assessment of cortex cinnamomi by HPLC chemical fingerprint, principle component analysis and cluster analysis.

    Yang, Jie; Chen, Li-Hong; Zhang, Qin; Lai, Mao-Xiang; Wang, Qiang


    HPLC fingerprint analysis, principle component analysis (PCA), and cluster analysis were introduced for quality assessment of Cortex cinnamomi (CC). The fingerprint of CC was developed and validated by analyzing 30 samples of CC from different species and geographic locations. Seventeen chromatographic peaks were selected as characteristic peaks and their relative peak areas (RPA) were calculated for quantitative expression of the HPLC fingerprints. The correlation coefficients of similarity in chromatograms were higher than 0.95 for the same species while much lower than 0.6 for different species. Besides, two principal components (PCs) have been extracted by PCA. PC1 separated Cinnamomum cassia from other species, capturing 56.75% of variance while PC2 contributed for their further separation, capturing 19.08% variance. The scores of the samples showed that the samples could be clustered reasonably into different groups corresponding to different species and different regions. The scores and loading plots together revealed different chemical properties of each group clearly. The cluster analysis confirmed the results of PCA analysis. Therefore, HPLC fingerprint in combination with chemometric techniques provide a very flexible and reliable method for quality assessment of traditional Chinese medicines.

  3. Diclosure and transparency in public sector: an analysis of convergence of the principles of governance

    Luzia Zorzal


    Full Text Available Introduction: Studies on disclosure of private institutions are common, but do not occur when it comes to public institutions, where the disclosure of management is still very limited. Purpose: The article is part of doctorate research in Information Science in progress and investigates the principles of disclosure and transparency in the light of good governance practices applied to the public sector, to reduce information asymmetry and presents part of this research. Methodology: The methodological procedures were performed literature search and content analysis to identify the principles and standards of good governance practices recommended for public administration, aiming to systematize these recommendations as instruments of governance and verify the convergence of the principles of disclosure and transparency. Results: Partial results show convergence of disclosure and transparency principles. Conclusions: Indicate that public institutions should worry about performing the practices of good governance as a way to mitigate the informational asymmetry.

  4. A Tentative Analysis on the Principles of Subtitling Translation



    Thanks to rapidly development on information technologies and economy globalization, the international culture inter⁃actions through movies and TV sequels have changed audiences viewing experience greatly. Accompanying with the actors ’and the actresses’own voices and natural breathing, the subtitled ones enable almost all the audiences to have a genuine, authentic movie time. Whereas the dubbed ones are comparatively costly and time consuming in the process of reproduction, it have gradu⁃ally faded out from our sights. This thesis conducts a brief survey and a tentative analysis on the strategies of subtitling translation with the case study of the famous TV series Emma, which is recomposed from one of greatest British Romantic Author Jane Aus⁃tin’s masterpieces.

  5. An introduction to DNA chips: principles, technology, applications and analysis.

    Gabig, M; Wegrzyn, G


    This review describes the recently developed GeneChip technology that provides efficient access to genetic information using miniaturised, high-density arrays of DNA or oligonucleotide probes. Such microarrays are powerful tools to study the molecular basis of interactions on a scale that would be impossible using conventional analysis. The recent development of the microarray technology has greatly accelerated the investigation of gene regulation. Arrays are mostly used to identify which genes are turned on or off in a cell or tissue, and also to evaluate the extent of a gene's expression under various conditions. Indeed, this technology has been successfully applied to investigate simultaneous expression of many thousands of genes and to the detection of mutations or polymorphisms, as well as for their mapping and sequencing.

  6. A new ordering principle for the classical statistical analysis of Poisson processes with background

    Giunti, C


    Inspired by the recent proposal by Feldman and Cousins of a ``unified approach to the classical statistical analysis of small signals'' based on a choice of ordering in Neyman's construction of classical confidence intervals, I propose a new ordering principle for the classical statistical analysis of Poisson processes with background which minimizes the effect on the resulting confidence intervals of the observation of less background events than expected. The new ordering principle is applied to the calculation of the confidence region implied by the recent null result of the KARMEN neutrino oscillation experiment.

  7. New ordering principle for the classical statistical analysis of Poisson processes with background

    Giunti, C.


    Inspired by the recent proposal by Feldman and Cousins of a ``unified approach to the classical statistical analysis of small signals'' based on a choice of ordering in Neyman's construction of classical confidence intervals, I propose a new ordering principle for the classical statistical analysis of Poisson processes with a background which minimizes the effect on the resulting confidence intervals of the observation of fewer background events than expected. The new ordering principle is applied to the calculation of the confidence region implied by the recent null result of the KARMEN neutrino oscillation experiment.

  8. Analysis of variable-rate well-test pressure data using Duhamel's principle

    Thompson, L.G.; Reynolds, A.C.


    This work considers the use of Duhamel's principle to analyze pressure drawdown and buildup data when both bottomhole pressures (BHP's) and sandface flow rates are available. This analysis procedure uses Duhamel's principle to convert pressure data obtained when the sandface rate is variable to the equivalent pressure data that would be obtained for a constant sandface rate of production. The equivalent constant-rate pressure data then can be analyzed with standard procedures (semilog analysis of type-curve matching).

  9. Laminar flow and convective transport processes scaling principles and asymptotic analysis

    Brenner, Howard


    Laminar Flow and Convective Transport Processes: Scaling Principles and Asymptotic Analysis presents analytic methods for the solution of fluid mechanics and convective transport processes, all in the laminar flow regime. This book brings together the results of almost 30 years of research on the use of nondimensionalization, scaling principles, and asymptotic analysis into a comprehensive form suitable for presentation in a core graduate-level course on fluid mechanics and the convective transport of heat. A considerable amount of material on viscous-dominated flows is covered.A unique feat

  10. Supporting Teachers in Designing CSCL Activities: A Case Study of Principle-Based Pedagogical Patterns in Networked Second Language Classrooms

    Wen, Yun; Looi, Chee-Kit; Chen, Wenli


    This paper proposes the identification and use of principle-based pedagogical patterns to help teachers to translate design principles into actionable teaching activities, and to scaffold student learning with sufficient flexibility and creativity. A set of pedagogical patterns for networked Second language (L2) learning, categorized and…

  11. The Operating Principle of a Fully Solid State Active Magnetic Regenerator

    Abdelaziz, Omar [ORNL


    As an alternative refrigeration technology, magnetocaloric refrigeration has the potential to be safer, quieter, more efficient, and more environmentally friendly than the conventional vapor compression refrigeration technology. Most of the reported active magnetic regenerator (AMR) systems that operate based on the magnetocaloric effect use heat transfer fluid to exchange heat, which results in complicated mechanical subsystems and components such as rotating valves and hydraulic pumps. This paper presents an operating principle of a fully solid state AMR, in which an alternative mechanism for heat transfer between the AMR and the heat source/sink is proposed. The operating principle of the fully solid state AMR is based on moving rods/sheets (e.g. copper, brass, iron or aluminum), which are employed to replace the heat transfer fluid. Such fully solid state AMR would provide a significantly higher heat transfer rate than a conventional AMR because the conductivity of moving solid rods/plates is high and it enables the increase in the machine operating frequency hence the cooling capacity. The details of operating principle are presented and discussed here. One of the key enabling features for this technology is the contact between the moving rods/sheets and magnetocaloric material, and heat exchange mechanism at the heat source/sink. This paper provides an overview of the design for a fully solid state magnetocaloric refrigeration system along with guidelines for their optimal design.

  12. 75 FR 8239 - School Food Safety Program Based on Hazard Analysis and Critical Control Point Principles (HACCP...


    ... Critical Control Point Principles (HACCP); Approval of Information Collection Request AGENCY: Food and... rule entitled School Food Safety Program Based on Hazard Analysis and Critical Control Point...

  13. Application of the comparison principle to analysis of nonlinear systems. [using Lipschitz condition and differential equations

    Gunderson, R. W.


    A comparison principle based on a Kamke theorem and Lipschitz conditions is presented along with its possible applications and modifications. It is shown that the comparison lemma can be used in the study of such areas as classical stability theory, higher order trajectory derivatives, Liapunov functions, boundary value problems, approximate dynamic systems, linear and nonlinear systems, and bifurcation analysis.

  14. Active materials for adaptive architectural envelopes based on plant adaptation principles

    Marlen Lopez


    Full Text Available In this paper, the authors present research into adaptive architectural envelopes that adapt to environmental changes using active materials, as a result of application of biomimetic principles from plants to architecture. Buildings use large amounts of energy in order to maintain their internal comfort, because conventional buildings are designed to provide a static design solution. Most of the current solutions for facades are not designed for optimum adaptation to contextual issues and needs, while biological solutions to adaptation are often complex, multi-functional and highly responsive. We focus on plant adaptations to the environment, as, due to their immobility, they have developed special means of protection against weather changing conditions. Furthermore, recent developments in new technologies are allowing the possibility to transfer these plant adaptation strategies to technical implementation. These technologies include: multi-material 3D printing, advances in materials science and new capabilities in simulation software. Unlike traditional mechanical activation used for dynamic systems in kinetic facades, adaptive architectural envelopes require no complex electronics, sensors, or actuators. The paper proposes a research of the relationship that can be developed between active materials and environmental issues in order to propose innovative and low-tech design strategies to achieve living envelopes according to plant adaptation principles.  

  15. Insurer’s activity as object of economic analysis

    O.O. Poplavskiy


    Full Text Available The article is devoted to the substantiation of theoretical fundamentals of insurer’s analysis and peculiarities of its implementation. The attention has been focused on the important role of economic analysis in economic science which is confirmed by its active use in research and practical orientation. The author summarizes the classification and principles of insurer’s activity analysis, supplements it with specific principles for insurer’s environment, publicity and risk-orientation which enable increasingly to take into account the peculiarities of insurance relations. The paper pays attention to the specification of elements of analysis and its key directions including the analysis of insurer’s financing, the analysis of insurance operations and the analysis of investment activity which will allow the effective functioning of risk management system.


    Zhang Hongwu; Wang Hui; Chen Biaosong; Xie Zhaoqian


    A new algorithm is developed based on the parametric variational principle for elastic-plastic analysis of Cosserat continuum. The governing equations of the classic elastic-plastic problem are regularized by adding rotational degrees of freedom to the conventional translational degrees of freedom in conventional continuum mechanics. The parametric potential energy principle of the Cosserat theory is developed, from which the finite element formulation of the Cosserat theory and the corresponding parametric quadratic programming model are constructed. Strain localization problems are computed and the mesh independent results are obtained.


    Monika Maříková


    Full Text Available Nowadays, enterprises are challenged with continuously changing environment and they have to react quickly to these changes. Process management can be a tool that greatly helps businesses in this difficult time to survive (Hora, 2010. Process Management brings a relatively new perspective on corporate governance. According to McCoy et al. (2007 enterprises which implemented rules of process management have a competitive advantage over others. The paper presents the application of the principles of process management in relation to the legal form of business enterprise and business activity. For determining the level of principles of process management the indicator MPP was used (Rolśnek, 2012; Truneček, 2005. Based on statistical analysis, it can be argued that there is a relationship between the application of the principles of process management, business legal forms and also business activities.

  18. Analysis on the Shift of Personal Pronoun in the Chinese Language - in Terms of Cooperative Principle and Politeness Principle



    Personal pronoun shift is a common phenomenon that by using second or third personal pronoun, the speaker means first personal pronoun;or speaker means second personal pronoun but uses first or third personal pronoun instead. Since the phe⁃nomenon frequently appears in the Chinese language, a great number of linguists have studied the personal pronoun and the inter⁃pretation of their usage. However, the study for the causes of the phenomenon is not so systemic. This paper aims to explain the personal pronoun shift from the perspective of Cooperative Principle and Politeness Principle, which can help to discover the rela⁃tionship between Cooperative principle and politeness in the shift of personal pronoun.

  19. Use of maximum entropy principle with Lagrange multipliers extends the feasibility of elementary mode analysis.

    Zhao, Quanyu; Kurata, Hiroyuki


    Elementary mode (EM) analysis is potentially effective in integrating transcriptome or proteome data into metabolic network analyses and in exploring the mechanism of how phenotypic or metabolic flux distribution is changed with respect to environmental and genetic perturbations. The EM coefficients (EMCs) indicate the quantitative contribution of their associated EMs and can be estimated by maximizing Shannon's entropy as a general objective function in our previous study, but the use of EMCs is still restricted to a relatively small-scale networks. We propose a fast and universal method that optimizes hundreds of thousands of EMCs under the constraint of the Maximum entropy principle (MEP). Lagrange multipliers (LMs) are applied to maximize the Shannon's entropy-based objective function, analytically solving each EMC as the function of LMs. Consequently, the number of such search variables, the EMC number, is dramatically reduced to the reaction number. To demonstrate the feasibility of the MEP with Lagrange multipliers (MEPLM), it is coupled with enzyme control flux (ECF) to predict the flux distributions of Escherichia coli and Saccharomycescerevisiae for different conditions (gene deletion, adaptive evolution, temperature, and dilution rate) and to provide a quantitative understanding of how metabolic or physiological states are changed in response to these genetic or environmental perturbations at the elementary mode level. It is shown that the ECF-based method is a feasible framework for the prediction of metabolic flux distribution by integrating enzyme activity data into EMs to genetic and environmental perturbations.

  20. The principles of the Brazilian Unified Health System, studied based on similitude analysis

    Ana Paula Munhen de Pontes


    Full Text Available OBJECTIVES: to analyze and compare the incorporation of the ethical-doctrinal and organizational principles into the social representations of the Unified Health System (SUS among health professionals. METHOD: a study grounded in Social Representations Theory, undertaken with 125 subjects, in eight health institutions in Rio de Janeiro. The free word association technique was applied to the induction term "SUS", the words evoked being analyzed using the techniques of the Vergès matrix and similitude analysis. RESULTS: it was identified that the professionals' social representations vary depending on their level of education, and that those with higher education represent a subgroup responsible for the process of representational change identified. This result was confirmed through similitude analysis. CONCLUSION: a process of representational change is ongoing, in which it was ascertained that the professionals incorporated the principles of the SUS into their symbolic constructions. The similitude analysis was shown to be a fruitful technique for research in nursing.

  1. First-Principles Study of Photochemical Activation of CO2 by Ti-based Oxides

    He, Haiying; Zapol, Peter; Curtiss, Larry


    The photochemical conversion of CO2 and H2O into energy-bearing hydrocarbon fuels provides an attractive way of mitigating the green-house gas CO2 and utilizing solar energy as a sustainable energy source. However, due to the high reduction potential and chemical inertness of CO2 molecules, the conversion rate of CO2 is impractically low. The activation of CO2 is critical in facilitating further reactions. By carrying out first-principles calculations of reaction pathways from CO2 to CO2-anions on Ti-based oxides including zeolites in the presence of photoexcited electrons, we have studied the initial step of CO2 activation via 1e transfer. It is shown that the CO2 reactivity of these surfaces strongly depends on the crystal structure, surface orientation, and presence of defects. This opens a new dimension in surface structure modification to enhance the CO2 adsorption and reduction on semiconductor surfaces.

  2. Activating Mg acceptors in AlN by oxygen: first principles calculations

    Wu, R Q


    First principles calculations based on density functional theory (DFT) are performed to study the electronic properties of Mg acceptors in AlN at the presence of oxygen. It is found that Mg and O tend to form complexes like Mg-O, Mg$_2$-O, Mg$_3$-O and Mg$_4$-O which have activation energies about 0.23 eV lower than that of Mg (except of the passive Mg-O). The lower activation energies originate from the extra states over valence band top of AlN induced by the passive Mg-O. By comparing to the well-established case of GaN, it is possible to fabricate Mg and O codoped AlN without MgO precipitate. These results suggest the possibility of achieving higher hole concentration in AlN by Mg and O codoping.

  3. Design Principles of Biological Oscillators through Optimization: Forward and Reverse Analysis

    Otero-Muras, Irene; Banga, Julio R.


    From cyanobacteria to human, sustained oscillations coordinate important biological functions. Although much has been learned concerning the sophisticated molecular mechanisms underlying biological oscillators, design principles linking structure and functional behavior are not yet fully understood. Here we explore design principles of biological oscillators from a multiobjective optimization perspective, taking into account the trade-offs between conflicting performance goals or demands. We develop a comprehensive tool for automated design of oscillators, based on multicriteria global optimization that allows two modes: (i) the automatic design (forward problem) and (ii) the inference of design principles (reverse analysis problem). From the perspective of synthetic biology, the forward mode allows the solution of design problems that mimic some of the desirable properties appearing in natural oscillators. The reverse analysis mode facilitates a systematic exploration of the design space based on Pareto optimality concepts. The method is illustrated with two case studies: the automatic design of synthetic oscillators from a library of biological parts, and the exploration of design principles in 3-gene oscillatory systems. PMID:27977695

  4. Determination of antioxidant activity of spices and their active principles by differential pulse voltammetry.

    Palma, Alberto; Ruiz Montoya, Mercedes; Arteaga, Jesús F; Rodríguez Mellado, Jose M


    The anodic oxidation of mercury in the presence of hydrogen peroxide in differential pulse voltammetry (DPV) was used to determine the antioxidant (AO) character of radical scavengers. Hydroperoxide radical is formed at the potentials of the oxidation peak on mercury electrodes, such radical reacting with the antioxidants in different extension. The parameter C10 (antioxidant concentration at which the peak area decreases by 10%) is used to measure the scavenging activity of the individual antioxidants. To establish the scavenging activity of antioxidant mixtures as a whole, the parameter, μ10 as the reverse of V10, V10 being the volume necessary to decrease the peak area in DPV by 10%, was selected. Higher μ10 values correspond to higher scavenging activity. The studies have been extended to aqueous extracts of some species. The results may be useful in explaining the effect of spices in vitro and in vivo studies.

  5. Clustering of frequency spectrums from different bearing fault using principle component analysis

    Yusof M.F.M.


    Full Text Available In studies associated with the defect in rolling element bearing, signal clustering are one of the popular approach taken in attempt to identify the type of defect. However, the noise interruption are one of the major issues which affect the degree of effectiveness of the applied clustering method. In this paper, the application of principle component analysis (PCA as a pre-processing method for hierarchical clustering analysis on the frequency spectrum of the vibration signal was proposed. To achieve the aim, the vibration signal was acquired from the operating bearings with different condition and speed. In the next stage, the principle component analysis was applied to the frequency spectrums of the acquired signals for pattern recognition purpose. Meanwhile the mahalanobis distance model was used to cluster the result from PCA. According to the results, it was found that the change in amplitude at the respective fundamental frequencies can be detected as a result from the application of PCA. Meanwhile, the application of mahalanobis distance was found to be suitable for clustering the results from principle component analysis. Uniquely, it was discovered that the spectrums from healthy and inner race defect bearing can be clearly distinguished from each other even though the change in amplitude pattern for inner race defect frequency spectrum was too small compared to the healthy one. In this work, it was demonstrated that the use of principle component analysis could sensitively detect the change in the pattern of the frequency spectrums. Likewise, the implementation of mahalanobis distance model for clustering purpose was found to be significant for bearing defect identification.

  6. Antifeedant activity of ethanolic extract from Flourensia oolepis and isolation of pinocembrin as its active principle compound.

    Diaz Napal, Georgina N; Carpinella, María C; Palacios, Sara M


    The ethanolic extract from Flourensia oolepis aerial parts showed strong antifeedant activity against the pest larvae, Epilachna paenulata, with an antifeedant index (AI%) of 99.1% at 100 microg/cm(2). Based on chromatographic fractionation of the extract, guided by bioassays on E. paenulata, the flavanone pinocembrin (1) was isolated as the most active principle. In a choice assay, compound 1 showed strong antifeedant activity against E. paenulata, Xanthogaleruca luteola and Spodoptera frugiperda with an AI% of 90, 94 and 91% (p<0.01) respectively, at 50 microg/cm(2). The dosages necessary for 50% feeding inhibition of the insects (ED(50)) were 7.98, 6.13 and 8.86 microg/cm(2), respectively. The feeding inhibitory activity of 1 against E. paenulata was compared with the activity of other structurally related flavonoids like naringenin, which was inactive up to 100 microg/cm(2), catechin which was nearly 6 times less active than 1, and quercetin which was equally active as 1. The effect of these on the feeding behavior of E. paenulata was also studied.

  7. Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells.

    Raghavenra, H; Diwakr, B T; Lokesh, B R; Naidu, K A


    Polymorphonuclear leukocytes (PMNL) play an important role in the modulation of inflammatory conditions in humans. PMNL cells recruited at the site of inflammation, release inflammatory mediators such as leukotrienes, proteolytic enzymes and reactive oxygen species. Among these, leukotrienes are implicated in pathophysiology of allergic and inflammatory disorders like asthma, allergic rhinitis, arthritis, inflammatory bowel disease and psoriasis. 5-lipoxygenase (5-LO) is the key enzyme in biosynthetic pathway of leukotrienes. Our earlier studies showed that spice phenolic active principles significantly inhibit 5-LO enzyme in human PMNLs. In this study we have further characterized the inhibitory mechanism of eugenol, the active principle of spice-clove on 5-LO enzyme and also its effect on leukotriene C((4)) (LTC(4)). Substrate dependent enzyme kinetics showed that the inhibitory effect of eugenol on 5-LO was of a non-competitive nature. Further, eugenol was found to significantly inhibit the formation of LTC(4) in calcium ionophore A23187 and arachidonic acid (AA) stimulated PMNL cells. These data clearly suggest that eugenol inhibits 5-LO by non-competitive mechanism and also inhibits formation of LTC(4) in human PMNL cells and thus may have beneficial role in modulating 5-LO pathway in human PMNL cells.

  8. Overseas and Domestic Research Status of Analysis of Humor from the Perspective of Cooperative Principle



    In Harvard University in 1967, an American linguistic philosopher, Grice, firstly put forward Cooperative Principle. From then on, overseas and domestic scholars began to pay much attention on CP, and analysis of humor from CP also became popular among researchers. The thesis reviews overseas and domestic research status of the research field from the violation of CP, in order to offer some constructive suggestions and research directions.

  9. Principles of ESCA and applications to metal corrosion, coating and lubrication. [Electron Spectroscopy for Chemical Analysis

    Wheeler, D. R.


    The principles of ESCA (electron spectroscopy for chemical analysis) are described by comparison with other spectroscopic techniques. The advantages and disadvantages of ESCA as compared to other surface sensitive analytical techniques are evaluated. The use of ESCA is illustrated by actual applications to oxidation of steel and Rene 41, the chemistry of lubricant additives on steel, and the composition of sputter deposited hard coatings. Finally, a bibliography of material that is useful for further study of ESCA is presented and commented upon.

  10. Contextual Mobile Learning Strongly Related to Industrial Activities: Principles and Case Study

    David, Bertrand; Chalon, René


    M-learning (mobile learning) can take various forms. We are interested in contextualized M-learning, i.e. the training related to the situation physically or logically localized. Contextualization and pervasivity are important aspects of our approach. We propose in particular MOCOCO principles (Mobility - COntextualisation - COoperation) using IMERA platform (Mobile Interaction in the Augmented Real Environment). We are studying various mobile learning contexts related to professional activities, in order to master appliances (Installation, Use, Breakdown diagnostic and Repairing). Contextualization, traceability and checking of execution of prescribed operations are based mainly on the use of RFID labels. Investigation of the appropriate training methods for this kind of learning situation, applying mainly a constructivist approach known as "Just-in-time learning", "learning by doing", "learning and doing", constitutes an important topic of this project. From an organizational point of view we are in perfect...

  11. Oncogenic and tumor-promoting Spermatophytes and Pteridophytes and their active principles.

    Farnsworth, N R; Bingel, A S; Fong, H H; Saleh, A A; Christenson, G M; Saufferer, S M


    A survey and discussion are presented of plants classified as Spermatophyta and Pteridophyta, extracts of which have been shown to be oncogenic or tumor-promoting in animals. The active oncogenic and tumor-promoting principles, where known, have been identified. They represent tannins; pyrrolizidine, indole, tropolone, quinoline, purine, and benzophenanthridine alkaloids; nitroso compounds; triterpene glycosides; lignans; isoflavans; allyl benzenoids; simple (nu-pyrenes; and carbocyclic hydroxy acids. A total of 28 compounds of known structure have been identified as oncogens and several phorbol esters as tumor-promoters. Plants known to contain any of the 28 oncogens (excluding shikimic acid and caffeine) have been tabulated; they represent at least 454 species, 110 genera, and 34 families of Spermatophyta and Pteridophyta.

  12. Contralateral delay activity tracks the influence of Gestalt grouping principles on active visual working memory representations.

    Peterson, Dwight J; Gözenman, Filiz; Arciniega, Hector; Berryhill, Marian E


    Recent studies have demonstrated that factors influencing perception, such as Gestalt grouping cues, can influence the storage of information in visual working memory (VWM). In some cases, stationary cues, such as stimulus similarity, lead to superior VWM performance. However, the neural correlates underlying these benefits to VWM performance remain unclear. One neural index, the contralateral delay activity (CDA), is an event-related potential that shows increased amplitude according to the number of items held in VWM and asymptotes at an individual's VWM capacity limit. Here, we applied the CDA to determine whether previously reported behavioral benefits supplied by similarity, proximity, and uniform connectedness were reflected as a neural savings such that the CDA amplitude was reduced when these cues were present. We implemented VWM change-detection tasks with arrays including similarity and proximity (Experiment 1); uniform connectedness (Experiments 2a and 2b); and similarity/proximity and uniform connectedness (Experiment 3). The results indicated that when there was a behavioral benefit to VWM, this was echoed by a reduction in CDA amplitude, which suggests more efficient processing. However, not all perceptual grouping cues provided a VWM benefit in the same measure (e.g., accuracy) or of the same magnitude. We also found unexpected interactions between cues. We observed a mixed bag of effects, suggesting that these powerful perceptual grouping benefits are not as predictable in VWM. The current findings indicate that when grouping cues produce behavioral benefits, there is a parallel reduction in the neural resources required to maintain grouped items within VWM.

  13. Analysis of Mixing Principle and Optimization of Parameter on the Single-shaft Horizontal Total Mixed Ration Mixer

    ZHANG Yu; WANG Defu


    The main structure and working principle of the single-shaft horizontal total mixed ration mixer was discussed.For studying the mixing principle,the analysis of force and motion of the material on the paddle were made,and paddle angle and rotational speed of the rotor were determined by the experiment,the main mixing ways were explained.

  14. Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation

    Bakhrouf Amina


    Full Text Available Abstract Background Thymoquinone is an active principle of Nigella sativa seed known as "Habbah Al-Sauda" in Arabic countries and "Sinouj" in Tunisia. Bacterial biofilms tend to exhibit significant tolerance to antimicrobials drugs during infections. Methods The antibacterial activity of Thymoquinone (TQ and its biofilm inhibition potencies were investigated on 11 human pathogenic bacteria. The growth and development of the biofilm were assessed using the crystal violet (CV and the 2, 3-bis [2-methyloxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide (XTT reduction assay. Results TQ exhibited a significant bactericidal activity against the majority of the tested bacteria (MICs values ranged from 8 to 32 μg/ml especially Gram positive cocci (Staphylococcus aureus ATCC 25923 and Staphylococcus epidermidis CIP 106510. Crystal violet assay demonstrated that the minimum biofilm inhibition concentration (BIC50 was reached with 22 and 60 μg/ml for Staphylococcus aureus ATCC 25923 and Staphylococcus epidermidis CIP 106510 respectively. In addition our data revealed that cells oxidative activity was influenced by TQ supplementation. In the same way, TQ prevented cell adhesion to glass slides surface. Conclusion The ability of TQ to prevent biofilm formation warrants further investigation to explore its use as bioactive substances with antibiofilm potential.

  15. The Principle of Mass Understood: A Qualitative Analysis for the Operational Planner



  16. Antiatherosclerotic Potential of Active Principle Isolated from Eugenia jambolana in Streptozotocin-Induced Diabetic Rats

    Reenu Singh Tanwar


    Full Text Available The aim of the present study was to investigate the antiatherosclerotic effect of active principle (FIIc isolated from aqueous fruit pulp extract of Eugenia jambolana. Crude aqueous extract of E. jambolana was subjected to purification using chromatographic techniques which yielded purified active compound (FIIc. Purity of FIIc was tested by HPLC. Phytochemical investigation of FIIc by NMR, IR, and UV spectra showed that the purified compound is α-hydroxy succinamic acid. The streptozotocin- (STZ- induced diabetic rats were fed atherosclerotic (Ath diet containing 1.5 mL olive oil containing 8 mg (3, 20,000 IU vitamin D2 and 40 mg cholesterol for 5 consecutive days. The STZ-induced diabetic rats receiving Ath diet were orally administered FIIc at doses of 10, 15, and 20 mg/kg, and results were compared with reference drug, that is, glibenclamide (600 μg/mg and healthy control. 30-day treatment with FIIc resulted in significant (P<.001 improvement in blood glucose, serum lipid profile, apolipoproteins (Apo A1 and apoB100, and endothelial dysfunction parameters. Histomorphological studies also confirmed biochemical findings. Our results showed that FIIc has protective effect on hyperglycemia-induced atherosclerosis.

  17. English Euphemism and its Linguistic Analysis from the Cooperative Principle Perspective



    Euphemism is a common phenomenon in languages. It’s a more mild and polite way to say something unpleasant and embarrassing. It’s a figure of speech as well as a cultural phenomenon. Euphemism functions to enhance the effect of communica-tion and maintain harmonious interpersonal relations. With the development of modern society, it has become an indispensable element in people's interactions. Many linguists and scholars have studied this linguistic phenomenon from different angles. Based on their achievements, the author has a tentative analysis of the three kinds of negative effects by using euphemism from the per-spective of Cooperative Principle.

  18. Analysis on the Foucault pendulum by De Alembert Principle and Numerical Simulation

    Zheng, Zhiwu


    In this paper, we handle the problem of the motion of the Foucault pendulum. We explore a new method induced from the De Alembert Principle giving the motional equations without small-amplitude oscillation approximation. The result of the problem is illustrated by numerical analysis showing the non-linear features and then with a comparison with a common method, showing the merit of this new original method. The result also shows that the argument changes in near-harmonic mode and the swing plane changes in pulsing way.

  19. Global Analysis of New Malaria Intrahost Models with a Competitive Exclusion Principle

    Iggidr, Abderrahman; Sallet, Gauthier; Tewa, Jean-Jules; 10.1137/050643271


    In this paper we propose a malaria within-host model with k classes of age for the parasitized red blood cells and n strains for the parasite. We provide a global analysis for this model. A competitive exclusion principle holds. If R0, the basic reproduction number, satisfies R0 1, then generically there is a unique endemic equilibrium which corresponds to the endemic stabilization of the most virulent parasite strain and to the extinction of all the other parasites strains. We prove that this equilibrium is globally asymptotically stable on the positive orthant if a mild sufficient condition is satisfied.

  20. Active Ageing: An Analysis

    Alina-Cristina Nuta


    Full Text Available The problem of ageing is a highly topical for Romania and for European Union. In this framework, to create and implement some strategies for active ageing is an important objective. The international and regional forums set (supported by official statistics that the number of older people growing rapidly. Romania needs some programmes (with labour, social, economic, health care aspects to deal with the demographic changes, programs that will reform the existing working life structures and legislation. Despite the actual pension reform, which tries to close the opportunity of early retirement (by penalizing the total pension flows, or increasing the retirement age, etc., the labour system does not sets some important targets for this area.

  1. In Vitro Inhibitory Effect of Clove Essential Oil and Its Two Active Principles on Tooth Decalcification by Apple Juice

    Charu M. Marya


    Full Text Available The dental erosion or decalcification of enamel is a significant clinical problem. Apple acidic beverages are thought to increase the potential for dental erosion. The purpose of this in vitro study was to investigate the effect of clove essential oil (CEO and its active principles on tooth decalcification of apple juices. On GC-MS analysis, CEO showed a high content of eugenol (58.29% and eugenyl acetate (19.10%. Teeth specimens were randomly divided into 5 treatment groups: control, CEO, eugenol, eugenyl-acetate, and fluoride. The specimens were exposed for 24 h and were analyzed for calcium contents using Inductively Coupled Plasma with Optical Emission Spectroscopy (ICP-OES. Data were analyzed using student t-test (<0.05. CEO, eugenol, and eugenyl-acetate significantly decreased the decalcification of tooth by the apple juice to only 17, 24, and 21 mgL−1, respectively. Hemolytic activity on human erythrocytes was studied to exclude the possibility of further associated cytotoxicity. It was observed that the CEO and its two lead molecules inhibit the decalcification and/or promote the remineralization caused by the apple juices. The effect of the test compounds appears to be distinct like that of fluoride treatment. CEO may, therefore, serve to be a promising adjunct to fluoride in the treatment of root caries during minimally invasive therapy.

  2. In Vitro Inhibitory Effect of Clove Essential Oil and Its Two Active Principles on Tooth Decalcification by Apple Juice

    Marya, Charu M.; Satija, Gunjan; J., Avinash; Nagpal, Ruchi; Kapoor, Rohtash; Ahmad, Aijaz


    The dental erosion or decalcification of enamel is a significant clinical problem. Apple acidic beverages are thought to increase the potential for dental erosion. The purpose of this in vitro study was to investigate the effect of clove essential oil (CEO) and its active principles on tooth decalcification of apple juices. On GC-MS analysis, CEO showed a high content of eugenol (58.29%) and eugenyl acetate (19.10%). Teeth specimens were randomly divided into 5 treatment groups: control, CEO, eugenol, eugenyl-acetate, and fluoride. The specimens were exposed for 24 h and were analyzed for calcium contents using Inductively Coupled Plasma with Optical Emission Spectroscopy (ICP-OES). Data were analyzed using student t-test (P < 0.05). CEO, eugenol, and eugenyl-acetate significantly decreased the decalcification of tooth by the apple juice to only 17, 24, and 21 mgL−1, respectively. Hemolytic activity on human erythrocytes was studied to exclude the possibility of further associated cytotoxicity. It was observed that the CEO and its two lead molecules inhibit the decalcification and/or promote the remineralization caused by the apple juices. The effect of the test compounds appears to be distinct like that of fluoride treatment. CEO may, therefore, serve to be a promising adjunct to fluoride in the treatment of root caries during minimally invasive therapy. PMID:22997520

  3. Principles and potential of the anaerobic digestion of waste-activated sludge

    Appels, Lise; Degreve, Jan [Department of Chemical Engineering, Katholieke Universiteit Leuven, W. De Croylaan 46, B-3001 Heverlee (Belgium); Baeyens, Jan [Department of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom); Dewil, Raf [Department of Chemical Engineering, Katholieke Universiteit Leuven, W. De Croylaan 46, B-3001 Heverlee (Belgium); Department of Chemical Engineering, Associated Faculty of Technology and Biosciences, Campus De Nayer, Katholieke Universiteit Leuven, Jan De Nayerlaan 5, B-2860 Sint-Katelijne-Waver (Belgium)


    When treating municipal wastewater, the disposal of sludge is a problem of growing importance, representing up to 50% of the current operating costs of a wastewater treatment plant. Although different disposal routes are possible, anaerobic digestion plays an important role for its abilities to further transform organic matter into biogas (60-70 vol% of methane, CH{sub 4}), as thereby it also reduces the amount of final sludge solids for disposal whilst destroying most of the pathogens present in the sludge and limiting odour problems associated with residual putrescible matter. Anaerobic digestion thus optimises WWTP costs, its environmental footprint and is considered a major and essential part of a modern WWTP. The potential of using the biogas as energy source has long been widely recognised and current techniques are being developed to upgrade quality and to enhance energy use. The present paper extensively reviews the principles of anaerobic digestion, the process parameters and their interaction, the design methods, the biogas utilisation, the possible problems and potential pro-active cures, and the recent developments to reduce the impact of the problems. After having reviewed the basic principles and techniques of the anaerobic digestion process, modelling concepts will be assessed to delineate the dominant parameters. Hydrolysis is recognised as rate-limiting step in the complex digestion process. The microbiology of anaerobic digestion is complex and delicate, involving several bacterial groups, each of them having their own optimum working conditions. As will be shown, these groups are sensitive to and possibly inhibited by several process parameters such as pH, alkalinity, concentration of free ammonia, hydrogen, sodium, potassium, heavy metals, volatile fatty acids and others. To accelerate the digestion and enhance the production of biogas, various pre-treatments can be used to improve the rate-limiting hydrolysis. These treatments include

  4. First-principles analysis of X-ray magnetic circular dichroism for transition metal complex oxides

    Ikeno, Hidekazu


    X-ray magnetic circular dichroism (XMCD) is widely used for the characterization of magnetism of materials. However, information from XMCD related to the atomic, electronic, and magnetic structures is not fully utilized due to the lack of reliable theoretical tools for spectral analysis. In this work, the first-principles configuration interaction (CI) calculations for X-ray absorption spectra developed by the author were extended for the calculation of XMCD, where the Zeeman energy was taken into the Hamiltonian of the CI to mimic magnetic polarization in the solid state. This technique was applied to interpret the L2,3 XMCD from 3d transition metal complex oxides, such as NiFe2O4 and FeTiO3. The experimental XMCD spectra were quantitatively reproduced using this method. The oxidation states as well as the magnetic ordering between transition metal ions on crystallographically different sites in NiFe2O4 can be unambiguously determined. A first-principles analysis of XMCD in FeTiO3 revealed the presence of Fe3+ and Ti3+ ions, which indicates that the charge transfer from Fe to Ti ions occurs. The origin of magnetic polarization of Ti ions in FeTiO3 was also discussed.

  5. Principles and Application of Magnetic Rubber Testing for Crack Detection in High-Strength Steel Components: I. Active-Field Inspection


    UNCLASSIFIED UNCLASSIFIED Principles and Application of Magnetic Rubber Testing for Crack Detection in High-Strength Steel Components: I...scientific principles governing both active-field and residual-field variants of MRT were examined. The results of theoretical and experimental...investigations into active-field MRT are documented in the current report, which describes the principles of active-field MRT, and then examines both the basis

  6. 无过错责任原则的经济分析%An Economic Analysis on Strict Liability Principle



    This paper tries to use the law of economic analysis method to study strict liability principle, with a view of highlighting the prevention function of the tort law and the efficiency. According to the analysis, strict liability principle in its applicable fields can make the externalities of infringement cost internalize better, prompt the tort-feasor to reduce active measures to prevent infringement, reduce the harm of the infringing act, prompt the infringer to pursue their own benefit and to achieve the optimal level of social prevention in the process; what is more, it can save the judicial resources, and make more victims get compensation for damage through exempting the cost of offering proofs that the tortfeasor is negligent or intentional. Therefore, strict liability principle has more advantages than fault liability principle in efficiency.%采用法律经济学的分析方法,以效率为视角并突出侵权责任法的预防功能来研究无过错责任原则,可以发现无过错责任原则在其适用的领域内,不仅能使侵权行为的外部性成本更好内部化,促使侵权人积极预防以减少侵权行为、降低侵权行为的危害程度,促使侵权人在追求自己利益最大化的过程中实现了社会的最优预防水平;而且还能节约司法资源,并通过免除了受害人举证过错的成本支出而使更多受害人能获得损害赔偿。从效率考察.无过错责任原则比过错责任原则更具优越性。


    Olha KHUDYK


    Full Text Available The article is devoted to the theoretical and methodological principles of strategic financial analysis of capital. The necessity of strategic financial analysis of capital as a methodological basis for study strategies is proved in modern conditions of a high level of dynamism, uncertainty and risk. The methodological elements of the strategic financial analysis of capital (the object of investigation, the indicators, the factors, the methods of study, the subjects of analysis, the sources of incoming and outgoing information are justified in the system of financial management, allowing to improve its theoretical foundations. It is proved that the strategic financial analysis of capital is a continuous process, carried out in an appropriate sequence at each stage of capital circulation. The system of indexes is substantiated, based on the needs of the strategic financial analysis. The classification of factors determining the size and structure of company’s capital is grounded. The economic nature of capital of the company is clarified. We consider that capital is a stock of economic resources in the form of cash, tangible and intangible assets accumulated by savings, which is used by its owner as a factor of production and investment resource in the economic process in order to obtain profit, to ensure the growth of owners’ prosperity and to achieve social effect.


    Olha KHUDYK


    Full Text Available The article is devoted to the theoretical and methodological principles of strategic financial analysis of capital. The necessity of strategic financial analysis of capital as a methodological basis for study strategies is proved in modern conditions of a high level of dynamism, uncertainty and risk. The methodological elements of the strategic indicators, the factors, the methods of study, the subjects of analysis, the sources of incoming and outgoing information are justified in the system of financial management, allowing to improve its theoretical foundations. It is proved that the strategic financial analysis of capital is a continuous process, carried out in an appropriate sequence at each stage of capital circulation. The system of indexes is substantiated, based on the needs of the strategic financial analysis. The classification of factors determining the size and structure of company’s capital is grounded. The economic nature of capital of the company is clarified. We consider that capital is a stock of economic resources in the form of cash, tangible and intangible assets accumulated by savings, which is used by its owner as a factor of production and investment resource in the economic process in order to obtain profit, to ensure the growth of owners’ prosperity and to achieve social effect.

  9. The principle and Application of the Multiple and Partial Coherence Analysis



    The basic principles of the partial and multiple coherence ananlysis and their utilization on vibration source idenfification are discussed in detail in this paper,The partial coherence analysis is the effective method of vibration source identification in multiple input-single output systems.Formerly,there was not any this kind of unction in the signal processor,and there was not and special software too.The software which we developed and used in the 7T 17S signal processor has this function.This software can be used not only for the parial and multiple coherence analysis of signal,but also for the correlation analysis,power spectrum analysis,transfer function analysis et al.We used this software to make the identifcation of the vibration source of the car floor board of electrical measuring vehicle,and to find the main factors which effect the vibration of the ear board.The excellent result was obtained.This method can also be used for making the identifications of noise source and other sources.

  10. Principles of multilevel analysis and its relevance to studies of antimicrobial resistance.

    Vellinga, Akke; Bennett, Kathleen; Murphy, Andrew W; Cormican, Martin


    When studying antimicrobial resistance it is clear that individuals do not exist in isolation and are often clustered into groups. Data within groups are generally not independent, but standard statistical approaches assume independence of observations. When data are clustered (e.g. students in schools, patients in general practices, etc.) multilevel analysis can be used. The overall idea of multilevel analysis is that the clustering is taken into account in the analysis and provides additional information on the interactions between individuals and groups. The lowest level is often the individual and additional levels are formed by clustering in groups (the higher levels). This article introduces the principles behind multilevel modelling. The approach is to provide readers with sufficient information to understand outcomes in which this statistical technique is used, without expecting the reader to be able to perform such an analysis. As multilevel modelling can be seen as an extension of linear regression analysis, this is the starting point of the article. Other concepts and terms are introduced throughout, resulting in the explanation of the accompanying article on antimicrobial prescribing and resistance in Irish general practice (Vellinga A, Tansey S, Hanahoe B et al. J Antimicrob Chemother 2012; 67: 2523-30).

  11. Study on Effect of IH764-3, an Active Principle of Salviae miltiorrhizae, in Inducing Hepatic Stellate Cell Apoptosis

    赵东强; 姜慧卿; 修贺明; 张晓岚


    Objective: To explore the anti-fibrotic mechanism of Salviae miltiorrhizae from the view of proliferation and apoptosis of hepatic stellate cells (HSC).Methods: IH764-3, an active principle of Salviae miltiorrhizae, was used to intervene in the cultured HSC in vitro. Cell proliferation was detected by methyl thiazolyl tetrazolium (MTT) method, and the cell apoptosis was examined by electron microscopy, flow cytometer and terminal deoxynucleotidyl transferase mediated dUTP nick-end-labeling method (TUNEL).Results: MTT showed that IH764-3 has obvious inhibition on the proliferation of HSC. Specific cell apoptosis figures of HSC, such as chromatin agglutination, were seen under electron microscopy in the IH764-3 treated group. By flow cytometer, it was shown that the HSC apoptosis rate in the IH764-3 treated group was higher than that in the control group, and the apoptosis inducing effect of IH764-3 was dose- and time-dependent. TUNEL analysis showed that the HSC apoptotsis rate was 28.3±1.5% after being incubated for 48 hrs with IH764-3, which was significantly higher than that in the control group (6.7±0.6%, P<0.05).Conclusion: IH764-3 could inhibit the proliferation of HSC and induce its apoptosis. These effects may be one of the anti-fibrotic mechanisms of Salviae miltiorrhizae.

  12. Analysis of environment elements in specific reservation of nature Stari Begej: Carska bara and principles of protection

    Mrkša Milutin


    Full Text Available The aim of this article is presentation a realistic status of environment elements in specific reservation of nature Stari Begej - Carska Bara. This article is present exchanged status of elements whose after effect operated the tourism activity. Principles of protection is present, too. Specific reservation of nature is area which comprehend one or more extra value of nature. Principles of protection are necessary for route, control and following.


    Виктор Макарович Заернюк


    Full Text Available In article established practices of the organization of control and supervision of Bank of Russia of activity of the Russian commercial banks are considered.  The analysis is carried out and the assessment of a level of development of a substantial component of bank regulation and supervision is given.Purpose: Research of tendencies and problems in the organization of control and supervising activity of Bank of Russia at the present stage.Methodology: General scientific methods were used: analysis and synthesis, comparisons, generalizations, system approach. In the course of use of the actual material methods of the economical and statistical analysis were used.Results: The conclusion that the excessive and bureaucratized control from the Central bank interferes with dynamic development of the banking sector is drawn. It is required to generation of the new thinking which is expressing in transfer of accent from need of strict, in many respects of formal, application of bank instructions and regulations on formation of professional opinion of the controler, increase of its responsibility for results of checks.DOI:

  14. Protection of ornamental gold fish Carassius auratus against Aeromonas hydrophila by treating Ixora coccinea active principles.

    Anusha, Paulraj; Thangaviji, Vijayaragavan; Velmurugan, Subramanian; Michaelbabu, Mariavincent; Citarasu, Thavasimuthu


    Herbals such as Ixora coccinea, Daemia extensa and Tridax procumbens were selected to screen in vitro antibacterial and immunostimulant activity against the freshwater fish pathogen Aeromonas hydrophila using different organic polar and non-polar solvents. Initial screening results revealed that, ethyl acetate extracts and its purified fraction of I. coccinea was able to suppress the A. hydrophila strains at more than 15 mm of zone of inhibition and positive immunostimulant activity. The purified active fraction, which eluted from H40: EA60 mobile phase was structurally characterized by GC-MS analysis. Two compounds such as Diethyl Phthalate (1,2-Benzene dicarboxylic acid, monobutyl ester) and Dibutyl Phthalate were characterized using NIST database search. In order to study the in vivo immunostimulant influence of the compounds, the crude extracts (ICE) and purified fractions (ICF) were incorporated to the artificial diets at the concentration of 400 mg kg⁻¹ and fed to the ornamental gold fish Carassius auratus for 30 days. After termination of feeding experiment, they were challenged with highly virulent A. hydrophila AHV-1 which was isolated from infected gold fish and studied the survival, specific bacterial load reduction, serum biochemistry, haematology, immunology and histological parameters. The control diet fed fishes succumbed to death within five days at 100% mortality whereas ICE and ICF fed groups survived 60 and 80% respectively after 10 days. The diets also helped to decrease the Aeromonas load after challenge and significantly (P ≤ 0.01) improved the serum albumin, globulin and protein. The diets also helped to increase the RBC and haemoglobin level significantly (P ≤ 0.05) from the control group. Surprisingly the immunological parameters like phagocytic activity, serum bactericidal activity and lysozyme activity were significantly increased (P ≤ 0.001) in the experimental diets. Macrophages and erythrocytes were abundantly expressed in the

  15. An Intrusion Detection System Model Based on Immune Principle and Performance Analysis

    CHEN Zhi-xian; WANG Ru-chuan; WANG Shao-di; SUN Zhi-xin


    The study of security in computer networks is a key issue,which is a rapidly growing area of interest because of its importance.Main network security problems are analyzed in this paper above all,which currently are confronted with network systems and existing works in intrusion detection.And then an intrusion detection system model based on Immune Principle(IPIDS)is presented.Meanwhile,it expatiates detailed implementation of the methods how to reduce the high false positive and negative alarms of the traditional Intrusion Detection System(IDS).At last a simple simulation is performed on this model just using string match algorithm as binding mechanism.The simulation results indicate that the model can detect malicious activity effectively,and consequently the security and steadiness of the whole network system are improved also.

  16. Analysis of Precision of Activation Analysis Method

    Heydorn, Kaj; Nørgaard, K.


    The precision of an activation-analysis method prescribes the estimation of the precision of a single analytical result. The adequacy of these estimates to account for the observed variation between duplicate results from the analysis of different samples and materials, is tested by the statistic T......, which is shown to be approximated by a χ2 distribution. Application of this test to the results of determinations of manganese in human serum by a method of established precision, led to the detection of airborne pollution of the serum during the sampling process. The subsequent improvement in sampling...... conditions was shown to give not only increased precision, but also improved accuracy of the results....

  17. Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks.

    Chang, Xiao; Wang, Zhuo; Hao, Pei; Li, Yuan-Yuan; Li, Yi-Xue


    The endosymbiotic theory proposed that mitochondrial genomes are derived from an alpha-proteobacterium-like endosymbiont, which was concluded from sequence analysis. We rebuilt the metabolic networks of mitochondria and 22 relative species, and studied the evolution of mitochondrial metabolism at the level of enzyme content and network topology. Our phylogenetic results based on network alignment and motif identification supported the endosymbiotic theory from the point of view of systems biology for the first time. It was found that the mitochondrial metabolic network were much more compact than the relative species, probably related to the higher efficiency of oxidative phosphorylation of the specialized organelle, and the network is highly clustered around the TCA cycle. Moreover, the mitochondrial metabolic network exhibited high functional specificity to the modules. This work provided insight to the understanding of mitochondria evolution, and the organization principle of mitochondrial metabolic network at the network level.


    ZHANG Hong-wu; WANG Hui


    The Voronoi cell finite element method (VCFEM) is adopted to overcome the limitations of the classic displacement based finite element method in the numerical simulation of heterogeneous materials. The parametric variational principle and quadratic programming method are developed for elastic-plastic Voronoi finite element analysis of two-dimensional problems. Finite element formulations are derived and a standard quadratic programming model is deduced from the elastic-plastic equations. Influence of microscopic heterogeneities on the overall mechanical response of heterogeneous materials is studied in detail. The overall properties of heterogeneous materials depend mostly on the size, shape and distribution of the material phases of the microstructure. Numerical examples are presented to demonstrate the validity and effectiveness of the method developed.

  19. Block Based Video Watermarking Scheme Using Wavelet Transform and Principle Component Analysis

    Nisreen I. Yassin


    Full Text Available In this paper, a comprehensive approach for digital video watermarking is introduced, where a binary watermark image is embedded into the video frames. Each video frame is decomposed into sub-images using 2 level discrete wavelet transform then the Principle Component Analysis (PCA transformation is applied for each block in the two bands LL and HH. The watermark is embedded into the maximum coefficient of the PCA block of the two bands. The proposed scheme is tested using a number of video sequences. Experimental results show high imperceptibility where there is no noticeable difference between the watermarked video frames and the original frames. The computed PSNR achieves high score which is 44.097 db. The proposed scheme shows high robustness against several attacks such as JPEG coding, Gaussian noise addition, histogram equalization, gamma correction, and contrast adjustment.

  20. [Civil responsibility of medical care activities in regard to the precautionary principle].

    Le Foyer de Costil, H


    In the absence of a legal body regulating the precaution, do we have to confine the principle to public health? A negative answer is required at a time the medical liability is increasing more and more and the obligation to take all means is slipping toward to a strict obligation as to the result. The respect of the principle of precaution can be found in the obligation for the doctor to prove that he has fully informed the patient, but the medicine specificity requires delimitation of this obligation outlines.

  1. Methodological principles outline discipline "Organization studies-tourism activity" using information technologies.

    Kozina Zh.L.


    Full Text Available The basic methodological principles of the disciplines of tourism and local history with information technology. 15 analyzed the literature and experience of leading experts in the field of sports and health tourism, and orienteering. Identified principles of academic disciplines of tourism and local history: the shift in emphasis from sports tourism to the cognitive, health tourism, the development of spiritual qualities, acquisition of life skills in nature, discovery and development of pedagogical and psychological abilities, character traits through the study of native land, the development of cognitive-research abilities, physical abilities, motor skills, application of modern information technology.

  2. The General Principles of EU Administrative Law - An in-depth analysis


    SUMMARY: 1. What are General Principles of EU Administrative Procedural Law? — 1.1. Sources of General Principles of EU Administrative Procedural Law. — 1.2. Nature of general principles of EU administrative procedural law. — 2. Why Formulate General Principles of EU Administrative Procedural Law as Recitals of a Regulation? — 2.1. Reasons in favour of recitals as a locus for general principles. — 2.2. Structure and wording of recitals. — 3. Proposed Recitals on General Princip...

  3. Industrial applications using BASF eco-efficiency analysis: perspectives on green engineering principles.

    Shonnard, David R; Kicherer, Andreas; Saling, Peter


    Life without chemicals would be inconceivable, but the potential risks and impacts to the environment associated with chemical production and chemical products are viewed critically. Eco-efficiency analysis considers the economic and life cycle environmental effects of a product or process, giving these equal weighting. The major elements of the environmental assessment include primary energy use, raw materials utilization, emissions to all media, toxicity, safety risk, and land use. The relevance of each environmental category and also for the economic versus the environmental impacts is evaluated using national emissions and economic data. The eco-efficiency analysis method of BASF is briefly presented, and results from three applications to chemical processes and products are summarized. Through these applications, the eco-efficiency analyses mostly confirm the 12 Principles listed in Anastas and Zimmerman (Environ. Sci. Technol. 2003, 37(5), 94A), with the exception that, in one application, production systems based on bio-based feedstocks were not the most eco-efficient as compared to those based on fossil resources. Over 180 eco-efficiency analyses have been conducted at BASF, and their results have been used to support strategic decision-making, marketing, research and development, and communication with external parties. Eco-efficiency analysis, as one important strategy and success factor in sustainable development, will continue to be a very strong operational tool at BASF.




    Full Text Available Each extension of the scope of laws and principles that allow both mathematical and statistical remodeling as well as reaffirming the appropriateness of proven methods, stirs up a special study interest. The ever-expanding computational power of laws of power offers to the scientific universe possibility of new approach to the crucial relationship between quantity and quality, between micro and macro dimensions. Boosting broadening the use of quasi-universal value theories in research in order to deepen the analysis of sustainable development indicators can lead to a greater understanding of all aspects of this area and to facilitate understanding of the arguments which underlie any responsible decision making. This assumption underlies the logical conclusion that sustainability becomes even stronger as it benefits from scientific arguments support resulting from research. Although we have confined ourselves in drafting some coordinates for application of each method presented to particular issues of sustainable development, this research theme will be strengthened and pursued through appropriate extensive analysis.

  5. Decoupling Principle Analysis and Development of a Parallel Three-Dimensional Force Sensor.

    Zhao, Yanzhi; Jiao, Leihao; Weng, Dacheng; Zhang, Dan; Zheng, Rencheng


    In the development of the multi-dimensional force sensor, dimension coupling is the ubiquitous factor restricting the improvement of the measurement accuracy. To effectively reduce the influence of dimension coupling on the parallel multi-dimensional force sensor, a novel parallel three-dimensional force sensor is proposed using a mechanical decoupling principle, and the influence of the friction on dimension coupling is effectively reduced by making the friction rolling instead of sliding friction. In this paper, the mathematical model is established by combining with the structure model of the parallel three-dimensional force sensor, and the modeling and analysis of mechanical decoupling are carried out. The coupling degree (ε) of the designed sensor is defined and calculated, and the calculation results show that the mechanical decoupling parallel structure of the sensor possesses good decoupling performance. A prototype of the parallel three-dimensional force sensor was developed, and FEM analysis was carried out. The load calibration and data acquisition experiment system are built, and then calibration experiments were done. According to the calibration experiments, the measurement accuracy is less than 2.86% and the coupling accuracy is less than 3.02%. The experimental results show that the sensor system possesses high measuring accuracy, which provides a basis for the applied research of the parallel multi-dimensional force sensor.

  6. Mobility analysis tool based on the fundamental principle of conservation of energy.

    Spletzer, Barry Louis; Nho, Hyuchul C.; Salton, Jonathan Robert


    In the past decade, a great deal of effort has been focused in research and development of versatile robotic ground vehicles without understanding their performance in a particular operating environment. As the usage of robotic ground vehicles for intelligence applications increases, understanding mobility of the vehicles becomes critical to increase the probability of their successful operations. This paper describes a framework based on conservation of energy to predict the maximum mobility of robotic ground vehicles over general terrain. The basis of the prediction is the difference between traction capability and energy loss at the vehicle-terrain interface. The mission success of a robotic ground vehicle is primarily a function of mobility. Mobility of a vehicle is defined as the overall capability of a vehicle to move from place to place while retaining its ability to perform its primary mission. A mobility analysis tool based on the fundamental principle of conservation of energy is described in this document. The tool is a graphical user interface application. The mobility analysis tool has been developed at Sandia National Laboratories, Albuquerque, NM. The tool is at an initial stage of development. In the future, the tool will be expanded to include all vehicles and terrain types.

  7. Basic Principles of the Activity and Synergetic Approach as a Means of Interdisciplinary Research

    Bolsunovskaya L.M.


    Full Text Available The paper considers the problem of interdisciplinarity as the main tendency of today’s science to unite the methodology and terminology and adapt them to any academic field in order to achieve more objective results in the study of complex phenomena. This article is a descriptive one and it deals with problems of terms’ interpretations and their adaptation to the anthropocentric research viewed by scientists of different academic schools. The main idea of the article is to find the most relevant and systemic definition of the given terms, which could be used as a tool in further linguistic analysis applied to the coming research of the authors. Special attention is paid to the description of the Activity Theory from different aspects of its interpretation: psychological, sociological, linguistic; to the explanation of the correlation between the epistemic structure of knowledge and an open non-linear synergetic bilateral (conceptual and lexical-semantic system influenced and motivated by processual factors to evolution in the modern discourse as the communicative activity of the interpreter and the constructor of discourse.

  8. Analysis on Phase Transformation (ATP) Using Computational Thermal Principles (CTP)

    N.Alagurmurthi; K.Palaniradja; V.Soundararajan


    Computer analysis based on computational thermal principles to predict the transformation kinetics in steels at varying temperatures is of great practical importance in different areas of heat treatment. As a result, using the theory of transient state heat conduction with convective boundary conditions, an efficient program named "ATP" (Analysis on Phase Transformation) has been developed to determine the temperature distribution under different quenching conditions for different geometries such as plate, cylinder and sphere. In addition to these the microstructures and the corresponding hardness developed during quenching are predicted using Time Temperature Transformation (TYF) diagram incorporated in the analysis. To approve our work, dilation curves, Heisler charts and time-temperature history curve have been generated. This paper deals with basic objective of the program (ATP) determination of temperature, microstructure and hardness distribution and also includes an online prediction of austenite-pearlite and anstenite-martensite transformation in steels along with the corresponding retained fractions. The quenching of a cylinder in gases, liquids and liquid metals is analyzed to show the non-liner effect of cylinder diameter on the temperature and microstructures. Further in the program we have considered a typical 1080 steel cylinders quenched in water for predicting and comparing the program results with experimental values and can be extended even to other grades of steels. The numerical results of program are found to be in good agreement with the experimental data obtained. Finally the quenching process analysis described in the study appears to be a promising tool for the design of heat-treatment process pararneters for steels.

  9. The Factors and Transversal Reorganizations Principles of Romanian Textile Industry Enterprises using Activity-Based Costing Method

    Sorinel Capusneanu


    Full Text Available This article describes the factors and the principles of transversal reorganization of the enterprises from the Romanian textile industry by adapting the Activity-Based Costing method (ABC to its specific. There are presented and analyzed the real possibilities of reorganization of the enterprises in Romania by elaboration of methodological phases that will be covered until the implementation of their transversal organization. Are we ready to adapt the Activity-Based Costing method to the specific of the Romanian textile industry and not only? Here is the question whose response we will find in this article.

  10. Mitogen activated protein kinase signaling pathways participate in the active principle region of Buyang Huanwu decoction-induced differentiation of bone marrow mesenchymal stem cells

    Jinghui Zheng; Jian Liang; Xin Deng; Xiaofeng Chen; Fasheng Wu; Xiaofang Zhao; Yuan Luo; Lei Fu; Zuling Jiang


    Our preliminary studies confirmed that an active principle region of Buyang Huanwu decoction, comprising alkaloid, polysaccharide, aglycon, glucoside and volatile oil, can induce bone marrow mesenchymal stem cell differentiation into neurons. Mitogen-activated protein kinase signaling was identified as one of the key pathways underlying this differentiation process. The present study shows phosphorylated extracellular signal-regulated protein kinase and phosphorylated p38 protein expression was increased after differentiation. Cellular signaling pathway blocking agents, PD98059 and SB203580, inhibited extracellular signal-regulated protein kinase and p38 in mitogen-activated protein kinase signaling pathways respectively. mRNA and protein expression of the neuronal marker, neuron specific enolase, and neural stem cell marker, nestin, were decreased in bone marrow mesenchymal stem cells after treatment with the active principle region of Buyang Huanwu decoction. Experimental findings indicate that, extracellular signal-regulated protein kinase and p38 in mitogen-activated protein kinase signaling pathways participate in bone marrow mesenchymal stem cell differentiation into neuron-like cells, induced by the active principle region of Buyang Huanwu decoction.

  11. Design principles for oxygen-reduction activity on perovskite oxide catalysts for fuel cells and metal-air batteries.

    Suntivich, Jin; Gasteiger, Hubert A; Yabuuchi, Naoaki; Nakanishi, Haruyuki; Goodenough, John B; Shao-Horn, Yang


    The prohibitive cost and scarcity of the noble-metal catalysts needed for catalysing the oxygen reduction reaction (ORR) in fuel cells and metal-air batteries limit the commercialization of these clean-energy technologies. Identifying a catalyst design principle that links material properties to the catalytic activity can accelerate the search for highly active and abundant transition-metal-oxide catalysts to replace platinum. Here, we demonstrate that the ORR activity for oxide catalysts primarily correlates to σ-orbital (e(g)) occupation and the extent of B-site transition-metal-oxygen covalency, which serves as a secondary activity descriptor. Our findings reflect the critical influences of the σ orbital and metal-oxygen covalency on the competition between O(2)(2-)/OH(-) displacement and OH(-) regeneration on surface transition-metal ions as the rate-limiting steps of the ORR, and thus highlight the importance of electronic structure in controlling oxide catalytic activity.

  12. Solar neutrino results and Violation of the Equivalence Principle An analysis of the existing data and predictions for SNO

    Majumdar, D; Sil, A; Majumdar, Debasish; Raychaudhuri, Amitava; Sil, Arunansu


    Violation of the Equivalence Principle (VEP) can lead to neutrino oscillation through the non-diagonal coupling of neutrino flavor eigenstates with the gravitational field. The neutrino energy dependence of this oscillation probability is different from that of the usual mass-mixing neutrino oscillations. In this work we explore, in detail, the viability of the VEP hypothesis as a solution to the solar neutrino problem in a two generation scenario with both the active and sterile neutrino alternatives, choosing these states to be massless. To obtain the best-fit values of the oscillation parameters we perform a chi square analysis for the total rates of solar neutrinos seen at the Chlorine (Homestake), Gallium (Gallex and SAGE), Kamiokande, and SuperKamiokande (SK) experiments. We find that the goodness of these fits is never satisfactory. It markedly improves if the Chlorine data is excluded from the analysis, especially for VEP transformation to sterile neutrinos. The 1117-day SK data for recoil electron sp...

  13. Achieving a predictable 24-hour return to normal activities after breast augmentation: part I. Refining practices by using motion and time study principles.

    Tebbetts, John B


    , lift their arms above their heads, lift normal-weight objects, and drive their car without any narcotic medications, drains, bandages, special bras, or other adjunctive treatments within 24 hours after their partial retropectoral breast augmentation. Applying motion and time study principles to analysis and refinement of surgeon and personnel actions and surgical techniques resulted in a substantial reduction in perioperative morbidity and a simpler, shorter 24-hour return to normal activities without intercostal blocks, narcotic pain medications, drains, bandages, or other adjunctive devices in 96 percent of 627 augmentation patients.

  14. An Analysis of Verbal Humor in Friends from the Perspective of Coopera-tive Principle



    Friends is a classical situation comedy in America in which humorous dialogues abound. With the theoretical frame-work of Cooperative Principle, this thesis extracts typical dialogues in American situation comedy Friends as data and discusses the characters’violation of maxims of Cooperative Principle together with the derived humorous effect.

  15. Microcalorimetric Evaluation of the Effect of Kanamycin: An Analysis Based on the Median-Effect Principle

    WANG,Li-Heng; FAN,Dai-Di; SHANG,Long-An; SHI,Hui-Juan; MA,Xiao-Xuan; MI,Yu; GU,Li-Feng; XU,Kang-Zhen


    A study of the effect of drug, kanamycin, on the growth metabolism of recombinant Escherichia coli B1 was carried out by microcalorimeter monitoring of the metabolic activity of treated cells. Power-time curves of growing recombinant Escherichia coli cell suspensions, treated with different kanamycin doses, were recorded. The extent of the effect was evaluated by changes in the slopes of the microcalorimetric curves and the kinetics of the drug action was interpreted from the time at which these changes reached their maximum values and maintained their maximum values. Experimental dose-effect relationships conform to the median-effect principle of the mass-action law:fa/(1-fa)=(D/D50)m. A plot of y=lg[(fa)1- 1]-1 versus x=lg D gives the slope m, D50 and R∞. The experimental results revealed that high concentration of kanamycin had an inhibitory effect on the growth of recombinant Escherichia coli B1 in the lg phase, and had a promoting effect in the stationary period. Moreover, it was demonstrated that microcalorimetry was a reliable method for the detection of modulatory effects in biology.

  16. Determination of Hypochlorite in Bleaching Products with Flower Extracts to Demonstrate the Principles of Flow Injection Analysis

    Ramos, Luiz Antonio; Prieto, Katia Roberta; Carvalheiro, Eder Tadeu Gomes; Carvalheiro, Carla Cristina Schmitt


    The use of crude flower extracts to the principle of analytical chemistry automation, with the flow injection analysis (FIA) procedure developed to determine hypochlorite in household bleaching products was performed. The FIA comprises a group of techniques based on injection of a liquid sample into a moving, nonsegmented carrier stream of a…

  17. Review of Transducer Principles for Label-Free Biomolecular Interaction Analysis

    Janos Vörös


    Full Text Available Label-free biomolecular interaction analysis is an important technique to study the chemical binding between e.g., protein and protein or protein and small molecule in real-time. The parameters obtained with this technique, such as the affinity, are important for drug development. While the surface plasmon resonance (SPR instruments are most widely used, new types of sensors are emerging. These developments are generally driven by the need for higher throughput, lower sample consumption or by the need of complimentary information to the SPR data. This review aims to give an overview about a wide range of sensor transducers, the working principles and the peculiarities of each technology, e.g., concerning the set-up, sensitivity, sensor size or required sample volume. Starting from optical technologies like the SPR and waveguide based sensors, acoustic sensors like the quartz crystal microbalance (QCM and the film bulk acoustic resonator (FBAR, calorimetric and electrochemical sensors are covered. Technologies long established in the market are presented together with those newly commercially available and with technologies in the early development stage. Finally, the commercially available instruments are summarized together with their sensitivity and the number of sensors usable in parallel and an outlook for potential future developments is given.

  18. Multiple scales combined principle component analysis deep learning network for face recognition

    Tian, Lei; Fan, Chunxiao; Ming, Yue


    It is well known that higher level features can represent the abstract semantics of original data. We propose a multiple scales combined deep learning network to learn a set of high-level feature representations through each stage of convolutional neural network for face recognition, which is named as multiscaled principle component analysis (PCA) Network (MS-PCANet). There are two main differences between our model and the traditional deep learning network. On the one hand, we get the prefixed filter kernels by learning the principal component of images' patches using PCA, nonlinearly process the convolutional results by using simple binary hashing, and pool them using spatial pyramid pooling method. On the other hand, in our model, the output features of several stages are fed to the classifier. The purpose of combining feature representations from multiple stages is to provide multiscaled features to the classifier, since the features in the latter stage are more global and invariant than those in the early stage. Therefore, our MS-PCANet feature compactly encodes both holistic abstract information and local specific information. Extensive experimental results show our MS-PCANet model can efficiently extract high-level feature presentations and outperform state-of-the-art face/expression recognition methods on multiple modalities benchmark face-related datasets.

  19. Image Denoising Algorithm Using Second Generation Wavelet Transformation and Principle Component Analysis

    Asem Khmag


    Full Text Available This study proposes novel image denoising algorithm using combination method. This method combines both Wavelet Based Denoising (WBD and Principle Component Analysis (PCA to increase the superiority of the observed image, subjectively and objectively. We exploit the important property of second generation WBD and PCA to increase the performance of our designed filter. One of the main advantages of the second generation wavelet transformation in noise reduction is its ability to keep the signal energy in small amount of coefficients in the wavelet domain. On the other hand, one of the main features of PCA is that the energy of the signal concentrates on a very few subclasses in PCA domain, while the noise’s energy equally spreads over the entire signal; this characteristic helps us to isolate the noise perfectly. Our algorithm compares favorably against several state-of-the-art filtering systems algorithms, such as Contourlet soft thresholding, Scale mixture by WT, Sparse 3D transformation and Normal shrink. In addition, the combined algorithm achieves very competitive performance compared with the traditional algorithms, especially when it comes to investigating the problem of how to preserve the fine structure of the tested image and in terms of the computational complexity reduction as well.

  20. Application of a principle of synchronicity to an analysis of climatic processes

    Tartakovsky, V. A.; Krutikov, V. A.; Volkov, Y. V.; Cheredko, N. N.


    Geospheric processes are largely initiated and controlled by external influences. The Sun is the main source of energy, and it contributes to those processes directly and as a regulator of some cosmic influences. The forcing effects synchronize the oscillatory processes in the solar system. Specific processes differ in energy. However, they show similar essential signs. Components, which differ in coincidence and non-coincidence of the essential signs, are introduced. Based on a synchronous analysis of the monthly averaged Wolf numbers series and temperatures registered at 818 weather stations in the Northern Hemisphere (1955-2010), we show that the above-introduced components of the series under consideration have extreme properties. The histograms of the primary temperature series coincide with those of their components, except for a range of ± 3°C. The second initial moments of the Wolf numbers correspond to the climate geography and can be divided into two zones, the width and the distance between them are about one third of all possible changes. A synchronicity principle allows performing a decomposition of the original set into subsets containing strongly related elements. The relationship between the synchronization features of geospheric processes initiated by external forcing and the physical and geographical hierarchy allows solving some problems of classification. Some experimental results for the temperature field are presented. The approach has revealed some new properties of the solar-terrestrial relations. No inconsistencies with the known notions of climatic processes have been found.

  1. Principles of transcriptome analysis and gene expression quantification: an RNA-seq tutorial.

    Wolf, Jochen B W


    Genome-wide analyses and high-throughput screening was long reserved for biomedical applications and genetic model organisms. With the rapid development of massively parallel sequencing nanotechnology (or next-generation sequencing) and simultaneous maturation of bioinformatic tools, this situation has dramatically changed. Genome-wide thinking is forging its way into disciplines like evolutionary biology or molecular ecology that were historically confined to small-scale genetic approaches. Accessibility to genome-scale information is transforming these fields, as it allows us to answer long-standing questions like the genetic basis of local adaptation and speciation or the evolution of gene expression profiles that until recently were out of reach. Many in the eco-evolutionary sciences will be working with large-scale genomic data sets, and a basic understanding of the concepts and underlying methods is necessary to judge the work of others. Here, I briefly introduce next-generation sequencing and then focus on transcriptome shotgun sequencing (RNA-seq). This article gives a broad overview and provides practical guidance for the many steps involved in a typical RNA-seq work flow from sampling, to RNA extraction, library preparation and data analysis. I focus on principles, present useful tools where appropriate and point out where caution is needed or progress to be expected. This tutorial is mostly targeted at beginners, but also contains potentially useful reflections for the more experienced.

  2. The Health Monitoring Method of Concrete Dams Based on Ambient Vibration Testing and Kernel Principle Analysis

    Lin Cheng


    Full Text Available The ambient vibration testing (AVT measurement of concrete dams on full-scale can show the practical dynamic properties of structure in the operation state. For most current researches, the AVT data is generally analyzed to identify the structural vibration characteristics, that is, modal parameters. The identified modal parameters, which can provide the global damage information or the damage location information of structure, can be used as the basis of structure health monitoring. Therefore, in this paper, the health monitoring method of concrete dams based on the AVT is studied. The kernel principle analysis (KPCA based method is adopted to eliminate the effect of environmental variables and monitor the health of dam under varying environments. By taking full advantage of the AVT data obtained from vibration observation system of dam, the identification capabilities and the warning capabilities of structural damage can be improved. With the simulated AVT data of the numerical model of a concrete gravity dam and the measured AVT data of a practical engineering, the performance of the dam health monitoring method proposed in this paper is verified.

  3. The Rethinking of the Economic Activity Based on Principles of Eco-Efficiency

    Daniela VÎRJAN


    Full Text Available Drought, floods, damaging storms, heat waves, acid rain, climate changes are but a few of the consequences of human action upon the environment. Can we possibly live against the environment? The answer is NO, and as such we must run an economy which respects the principles of eco-efficiency because only so can economic progress go on. Green economy is a great opportunity for all of the world’s countries, and is a real economy which keeps the resource-needs and environment relation in balance, aims towards quality and not quantity, lays emphasis on regeneration, recycling, reuse and creativity. Eco-efficiency implies both innovation towards a high degree of product dematerialization, services and systems, alongside with greatly changing current production and consumption practices. If we produce based on the principle of eco-efficiency we can reduce the effects of the profound economic, ecological, socio-political and cultural-spiritual crisis which marks our planet and countries.

  4. ISLAMISM & DEMOCRACY: A Gender Analysis on PKS’s Application of Democratic Principles and Values

    Lanny Octavia


    Full Text Available The increasing popular support for Islamist parties in democratic countries incites public suspicion concerning whether the Islamists’ participation in procedural democracy guarantees their commitment for substantial democracy, which in principle requires equality of rights among citizens regardless of their religion and gender. Indeed, gender politics often appears at the centre of the lslamist agenda, as they seek to construct a new moral order based on a conservative gender perspective. A greater concern arises on whether the Islamists will eventually lead society towards democracy or, conversely, towards theocracy. In Indonesia, the Prosperous Justice Party (Partai Keadilan Sejahtera/PKS shows a remarkable development and significant electoral achievement. Some observers viewed that PKS is opportunistically using democratic means to “hijack” it for their Islamist agenda waiting for when political power is in their hands. Others believe PKS’s involvement in real politics will, in the end, lead to a “gradual secularisation” of their Islamist agenda. Based on a gender analysis, this paper examines whether PKS’s fulfillment of the formalist criteria of democracy is compatible with their application of democratic principles and values.[Semakin menguatnya dukungan terhadap partai Islam memincu kecurigaan publik yang mempertanyakan apakah partisipasi kalangan islamis dalam demokrasi prosedural menjamin komitmen mereka bagi tegaknya demokrasi substansial, demokrasi yang mensyaratkan kesetaraan bagi semua orang tanpa terkecuali. Sebenarnya, agenda politik gender yang didengungkan oleh kalangan islamis tidak bisa dilepaskan dari perspektif konservatif mereka mengenai relasi gender. Pertanyaannya kemudian, apakah yang mereka agendakan akan berlabuh pada pemantapan demokrasi atau --sebaliknya‍‑­‑ menuju teokrasi. Di Indonesia, Partai Keadilan Sejahtera (PKS adalah satu-satunya partai Islam di Indonesia yang berhasil berkembang pesat

  5. Characterization of deep aquifer dynamics using principle component analysis of sequential multilevel data

    D. Kurtzman


    Full Text Available Two sequential multilevel profiles were obtained in an observation well opened to a 130 m thick, unconfined, contaminated aquifer, in Tel Aviv, Israel. While the general profile characteristics of major ions, trace elements, and Volatile Organic Compounds (VOC were maintained in the two sampling campaigns conducted 295 days apart, the vertical locations of high concentration gradients were shifted between the two profiles. Principle Component Analysis (PCA of the chemical variables resulted in a first Principal Component (PC which was responsible for ∼60% of the variability, and was highly correlated with depth. PCA revealed three distinct depth-dependent water bodies in both multilevel profiles, which were found to be shifted vertically between the sampling events. This shift cut across a clayey bed which separated between the top and intermediate water bodies in the first profile, and was located entirely within the intermediate water body in the second profile. Continuous Electrical Conductivity (EC monitoring in a packed off section of the observation well revealed an event in which a distinct water body flowed through the monitored section (v ∼ 150 m yr−1. Compilation of the aforementioned data and analysis lead to a conclusion that the observed changes in the profiles resulted from dominantly lateral flow of water bodies in the aquifer rather than vertical flow. The significance of this study is twofold: (a it demonstrates the utility of sequential multilevel observations from deep wells and the efficacy of PCA for evaluating this data. (b The fact that distinct water bodies of 10–100 m vertical and horizontal dimensions flow under contaminated sites has implications for monitoring and remediation.

  6. The neural circuits for arithmetic principles.

    Liu, Jie; Zhang, Han; Chen, Chuansheng; Chen, Hui; Cui, Jiaxin; Zhou, Xinlin


    Arithmetic principles are the regularities underlying arithmetic computation. Little is known about how the brain supports the processing of arithmetic principles. The current fMRI study examined neural activation and functional connectivity during the processing of verbalized arithmetic principles, as compared to numerical computation and general language processing. As expected, arithmetic principles elicited stronger activation in bilateral horizontal intraparietal sulcus and right supramarginal gyrus than did language processing, and stronger activation in left middle temporal lobe and left orbital part of inferior frontal gyrus than did computation. In contrast, computation elicited greater activation in bilateral horizontal intraparietal sulcus (extending to posterior superior parietal lobule) than did either arithmetic principles or language processing. Functional connectivity analysis with the psychophysiological interaction approach (PPI) showed that left temporal-parietal (MTG-HIPS) connectivity was stronger during the processing of arithmetic principle and language than during computation, whereas parietal-occipital connectivities were stronger during computation than during the processing of arithmetic principles and language. Additionally, the left fronto-parietal (orbital IFG-HIPS) connectivity was stronger during the processing of arithmetic principles than during computation. The results suggest that verbalized arithmetic principles engage a neural network that overlaps but is distinct from the networks for computation and language processing.


    GU Chong-shi; SONG Jing-xiang; FANG Hai-ting


    The effect zones of layer face for RCC (rolled control concrete) dam have gradual change characteristics. Based on the analysis thought of complex material, a model was built to analyze above principle of RCC dam by use of series-wound and shunt-wound connection. Some methods were proposed to determine the instantaneous Young's modulus, delayed Young's modulus and viscosity coefficient of effect zones of layer face. Above models and methods were used to mine the principle of gradual change of key calculation parameters which can response the characteristics of effect zones. The principle of gradual change was described. A model was established to analyze the threedimensional viscoelastic problem of RCC dam. Above programs were developed. The examples show that the proposed models and methods to determine the key calculation parameters of effect zones can reflect the status of RCC darn accurately.

  8. Performance Analysis for Dispensing Mechanism of Active Code


    The dispensing mechanism of active code is a key technology in an active network. Conventional capsule and programmable switch approaches have their own shortcomings. The DCCAN(distributed code caching for active network) mechanism presented in this paper overcomes these shortcomings. In this paper, capsule and programmable switch approaches are introduced, and their shortcomings are analyzed. The principle of the DCCAN mechanism is described. The theory analysis in transmit width based on the DCCAN mechanism and capsule approach are described. The theory analysis shows that the DCCAN mechanism has many good characteristics and can improve the efficiency of an active network. Key factors which affect the transmit width based on the DCCAN mechanism are discussed. The using condition of the DCCAN mechanism is also discussed.

  9. Content Analysis and Readibility Formulas as Applied To The Accounting Principles Board "Opinions"

    Stead, Bette Ann


    Discusses a study analyzing twenty-four of the Accounting Principles Board "Opinions" (APB Opinions) and concludes that the APB context is very difficult to read and understand for both accounting and nonaccounting majors. (MH)

  10. Principles and indicators of successful consumer involvement in NHS research: results of a Delphi study and subgroup analysis.

    Boote, Jonathan; Barber, Rosemary; Cooper, Cindy


    Consumer involvement in NHS research is Department of Health policy within the UK. Despite the existence of policy directives and guidance, until recently there has been no consensus among consumers and researchers about what it means to involve consumers successfully in NHS research. This paper discusses the value of consensus research in this policy area, and presents the detailed findings of a Delphi study carried out to reach consensus on principles and indicators of successful consumer involvement in NHS research. Study participants, comprising consumers, researchers and consumer-researchers, were identified using a purposive sampling strategy. Consensus was reached on eight clear and valid principles of successful consumer involvement in NHS research, with each principle having at least one clear and valid indicator. Subgroup analysis revealed few significant differences in how consumers, researchers and consumer-researchers rated the principles and indicators. The implications and limitations of the study are discussed. Further research is needed to assess: (1) the usefulness of the principles and indicators for differing models of consumer involvement, health research methodologies, and subject areas within health research; and (2) the impact of 'successful' consumer involvement on health research processes and outcomes.

  11. Growth inhibition and differentiation of promyelocytic cells (HL-60) induced by BC-4, an active principle from Boswellia carterii Birdw.

    Jing, Y; Xia, L; Han, R


    The induction of cell differentiation and growth inhibition of HL-60 cells by Bc-4, an active principle from Boswellia carterii, was studied in vitro and in vivo. The proliferation of HL-60 cells was found to be inhibited by Bc-4 at a concentration of 5-10 micrograms/ml. Under the action of Bc-4, the acid phosphatase and NBT reduction activities in HL-60 cells were increased, and phagocytosis of cells was also induced. All these activities were concentration dependent. The HL-60 cells were induced by Bc-4 to differentiate into more mature cells morphologically. The in vivo growth of HL-60 cells in mouse subrenal capsules (SRC) and in diffusion chambers inoculated into mice was inhibited by Bc-4 at a dose of 50 mg/kg. The morphology of HL-60 cells treated by Bc-4 in diffusion chambers exhibited characteristics of mature granulocytic cells.

  12. Interpreting the Geochemistry of the Northern Peninsula Ranges Batholith Using Principle Component Analysis and Spatial Interpolation

    Pompe, L.; Clausen, B. L.; Morton, D. M.


    The Cretaceous northern Peninsular Ranges batholith (PRB) exemplifies emplacement in a combination oceanic arc / continental margin arc setting. Two approaches that can aid in understanding its statistical and spatial geochemistry variation are principle component analysis (PCA) and GIS interpolation mapping. The data analysis primarily used 287 samples from the large granitoid geochemical data set systematically collected by Baird and Welday. Of these, 80 points fell in the western Santa Ana block, 108 in the transitional Perris block, and 99 in the eastern San Jacinto block. In the statistical analysis, multivariate outliers were identified using Mahalanobis distance and excluded. A centered log ratio transformation was used to facilitate working with geochemical concentration values that range over many orders of magnitude. The data was then analyzed using PCA with IBM SPSS 21 reducing 40 geochemical variables to 4 components which are approximately related to the compatible, HFS, HRE, and LIL elements. The 4 components were interpreted as follows: (1) compatible [and negatively correlated incompatible] elements indicate extent of differentiation as typified by SiO2, (2) HFS elements indicate crustal contamination as typified by Sri and Nb/Yb ratios, (3) HRE elements indicate source depth as typified by Sr/Y and Gd/Yb ratios, and (4) LIL elements indicate alkalinity as typified by the K2O/SiO2ratio. Spatial interpolation maps of the 4 components were created with Esri ArcGIS for Desktop 10.2 by interpolating between the sample points using kriging and inverse distance weighting. Across-arc trends on the interpolation maps indicate a general increase from west to east for each of the 4 components, but with local exceptions as follows. The 15km offset on the San Jacinto Fault may be affecting the contours. South of San Jacinto is a west-east band of low Nb/Yb, Gd/Yb, and Sr/Y ratios. The highest Sr/Y ratios in the north central area that decrease further east may

  13. Investigation of variation in gene expression profiling of human blood by extended principle component analysis.

    Qinghua Xu

    Full Text Available BACKGROUND: Human peripheral blood is a promising material for biomedical research. However, various kinds of biological and technological factors result in a large degree of variation in blood gene expression profiles. METHODOLOGY/PRINCIPAL FINDINGS: Human peripheral blood samples were drawn from healthy volunteers and analysed using the Human Genome U133Plus2 Microarray. We applied a novel approach using the Principle Component Analysis and Eigen-R(2 methods to dissect the overall variation of blood gene expression profiles with respect to the interested biological and technological factors. The results indicated that the predominating sources of the variation could be traced to the individual heterogeneity of the relative proportions of different blood cell types (leukocyte subsets and erythrocytes. The physiological factors like age, gender and BMI were demonstrated to be associated with 5.3% to 9.2% of the total variation in the blood gene expression profiles. We investigated the gene expression profiles of samples from the same donors but with different levels of RNA quality. Although the proportion of variation associated to the RNA Integrity Number was mild (2.1%, the significant impact of RNA quality on the expression of individual genes was observed. CONCLUSIONS: By characterizing the major sources of variation in blood gene expression profiles, such variability can be minimized by modifications to study designs. Increasing sample size, balancing confounding factors between study groups, using rigorous selection criteria for sample quality, and well controlled experimental processes will significantly improve the accuracy and reproducibility of blood transcriptome study.

  14. Application of bioreactor design principles and multivariate analysis for development of cell culture scale down models.

    Tescione, Lia; Lambropoulos, James; Paranandi, Madhava Ram; Makagiansar, Helena; Ryll, Thomas


    A bench scale cell culture model representative of manufacturing scale (2,000 L) was developed based on oxygen mass transfer principles, for a CHO-based process producing a recombinant human protein. Cell culture performance differences across scales are characterized most often by sub-optimal performance in manufacturing scale bioreactors. By contrast in this study, reduced growth rates were observed at bench scale during the initial model development. Bioreactor models based on power per unit volume (P/V), volumetric mass transfer coefficient (kL a), and oxygen transfer rate (OTR) were evaluated to address this scale performance difference. Lower viable cell densities observed for the P/V model were attributed to higher sparge rates and reduced oxygen mass transfer efficiency (kL a) of the small scale hole spargers. Increasing the sparger kL a by decreasing the pore size resulted in a further decrease in growth at bench scale. Due to sensitivity of the cell line to gas sparge rate and bubble size that was revealed by the P/V and kL a models, an OTR model based on oxygen enrichment and increased P/V was selected that generated endpoint sparge rates representative of 2,000 L scale. This final bench scale model generated similar growth rates as manufacturing. In order to take into account other routinely monitored process parameters besides growth, a multivariate statistical approach was applied to demonstrate validity of the small scale model. After the model was selected based on univariate and multivariate analysis, product quality was generated and verified to fall within the 95% confidence limit of the multivariate model.

  15. "JCE" Classroom Activity #108. Using Archimedes' Principle to Explain Floating and Sinking Cans

    Sanger, Michael J.


    In this activity, students (working alone or in groups) measure the mass of several soda cans (diet and regular soda) along with the mass of water that each can displaces. The students are then asked to compare these two mass values for the sinking cans and for the floating cans. The purpose of this activity is for students to determine that the…

  16. Distributed smart home activity recommender system using hidden Markov model principles

    Lynggaard, Per


    A smart home is able to propose learned activities to its user and learn new activities by observing the user’s behavioral patterns, that is, the user’s actions. Most of today’s discussed systems use some more or less complex classifier algorithms to predict user activities from contextual...... information provided by sensors. However, an alternative concept using a distributed framework is presented in this paper. It offers the possibility of combining simple low level activity classifiers with a more sophisticated one. The high level classifier has been modeled in Java and tested on a publicly...... available data set that offers approximately seven months of annotated activity including 6468 sensor events produced by a women living in the test home. Using this data set, it has been shown that this system can achieve good performance with a recognition probability of 75%....

  17. A Crystallin Fold in the Interleukin-4-inducing Principle of Schistosoma mansoni Eggs (IPSE/α-1) Mediates IgE Binding for Antigen-independent Basophil Activation.

    Meyer, N Helge; Mayerhofer, Hubert; Tripsianes, Konstantinos; Blindow, Silke; Barths, Daniela; Mewes, Astrid; Weimar, Thomas; Köhli, Thies; Bade, Steffen; Madl, Tobias; Frey, Andreas; Haas, Helmut; Mueller-Dieckmann, Jochen; Sattler, Michael; Schramm, Gabriele


    The IL-4-inducing principle from Schistosoma mansoni eggs (IPSE/α-1), the major secretory product of eggs from the parasitic worm S. mansoni, efficiently triggers basophils to release the immunomodulatory key cytokine interleukin-4. Activation by IPSE/α-1 requires the presence of IgE on the basophils, but the detailed molecular mechanism underlying activation is unknown. NMR and crystallographic analysis of IPSEΔNLS, a monomeric IPSE/α-1 mutant, revealed that IPSE/α-1 is a new member of the βγ-crystallin superfamily. We demonstrate that this molecule is a general immunoglobulin-binding factor with highest affinity for IgE. NMR binding studies of IPSEΔNLS with the 180-kDa molecule IgE identified a large positively charged binding surface that includes a flexible loop, which is unique to the IPSE/α-1 crystallin fold. Mutational analysis of amino acids in the binding interface showed that residues contributing to IgE binding are important for IgE-dependent activation of basophils. As IPSE/α-1 is unable to cross-link IgE, we propose that this molecule, by taking advantage of its unique IgE-binding crystallin fold, activates basophils by a novel, cross-linking-independent mechanism.

  18. A Cu-amyloid β complex activating Fenton chemistry in Alzheimer's disease: Learning with multiple first-principles simulations

    La Penna, Giovanni; Hureau, Christelle; Faller, Peter


    Amyloid β peptides form complexes with copper, both in vitro and in vivo, relatively soluble in water as oligomers and active as catalysts for oxidation of organic substrates by hydrogen peroxide, a species always present in cells and in their aerobic environment. All these species are present in the synapse, thus making a connection between the amyloid cascade hypothesis and the oxidative damages by reactive oxygen species in neurons, when pathological dishomeostasis of amyloid peptides and metal ions occur. In order to understand the structural features of these toxic complexes, we built several models of Cu-Aβ peptides in monomeric and dimeric forms and we found, performing multiple first-principles molecular dynamics simulations, that Cu-induced dimers are more active than monomers in converting hydrogen peroxide into aggressive hydroxyl radicals.

  19. Strategic consistency of enterprise logistics activities on the bases of ecological principles

    N.M. Mashchak


    Full Text Available The consistency of logistics enterprises with environmental strategies investigated. Examples of foreign experience and results of such consistency in practice are given. The necessity and strategic advantages of logistic activities on environmental grounds proved.

  20. The ethics of secondary data analysis: considering the application of Belmont principles to the sharing of neuroimaging data.

    Brakewood, Beth; Poldrack, Russell A


    The sharing of data is essential to increasing the speed of scientific discovery and maximizing the value of public investment in scientific research. However, the sharing of human neuroimaging data poses unique ethical concerns. We outline how data sharing relates to the Belmont principles of respect-for-persons, justice, and beneficence. Whereas regulators of human subjects research often view data sharing solely in terms of potential risks to subjects, we argue that the principles of human subject research require an analysis of both risks and benefits, and that such an analysis suggests that researchers may have a positive duty to share data in order to maximize the contribution that individual participants have made.

  1. Pomegranate juice and prostate cancer: importance of the characterisation of the active principle.

    Chrubasik-Hausmann, Sigrun; Vlachojannis, Christian; Zimmermann, Benno


    Two exploratory clinical studies investigating proprietary pomegranate products showed a trend of effectiveness in increasing prostate-specific antigen doubling time in patients with prostate cancer. A recent clinical study did not support these results. We therefore analysed a lot of the marketed pomegranate blend for co-active pomegranate compounds. The high-performance liquid chromatography method was used to detect punicalagin, ellagic acid and anthocyanins. Total polyphenoles were determined by the Folin-Ciocalteu method using gallic acid as reference. The results show that the co-active compounds in the daily dose of the pomegranate blend were far below those previously tested and that the photometric assessment is not reliable for the standardisation of study medications. Not pomegranate but the low amount of co-active compounds in the proprietary pomegranate blend was responsible for its clinical ineffectiveness.

  2. Current parallel chemistry principles and practice: application to the discovery of biologically active molecules.

    Edwards, Paul J


    This article describes the use of parallel chemistry techniques for drug discovery, based on publications from January 2006 to December 2008. Chemical libraries that yielded active compounds across a range of biological targets are presented, together with synthetic details when appropriate. Background information for the biological targets involved and any SAR that could be discerned within members of a library series also is discussed. New technological developments, as applied to library design and synthesis and, more generally, in the discovery of biologically active entities, are highlighted. In addition, the likely future directions for parallel chemistry in its ability to impact upon drug discovery are also presented.

  3. Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle.

    Orhan, Didem Deliorman; Aslan, Mustafa; Aktay, Göknur; Ergun, Ender; Yesilada, Erdem; Ergun, Fatma


    Hepatoprotective effect of Gentiana olivieri Griseb. (Gentianaceae) flowering herbs on subacute administration were studied using in vivo models in rats. For the activity assessment on carbon tetrachloride-induced hepatic damage following biochemical parameters were evaluated; plasma and hepatic tissue malondialdehyde formation, and liver tissue glutathione level, as well as plasma transaminase enzyme levels (aspartate transferase and alanine transferase). Results of biochemical tests were also confirmed by histopathological examination. Through bioassay-guided fractionation procedures isoorientin, a known C-glycosylflavone, was isolated from the ethyl acetate fraction as the active antihepatotoxic constituent by silica gel column chromatography. Isoorientin exhibited significant hepatoprotective effect at 15 mg/kg b.w. dose.

  4. Radiometric and spectral calibrations of the Geostationary Imaging Fourier Transform Spectrometer (GIFTS) using principle component analysis

    Tian, Jialin; Smith, William L.; Gazarik, Michael J.


    The ultimate remote sensing benefits of the high resolution Infrared radiance spectrometers will be realized with their geostationary satellite implementation in the form of imaging spectrometers. This will enable dynamic features of the atmosphere's thermodynamic fields and pollutant and greenhouse gas constituents to be observed for revolutionary improvements in weather forecasts and more accurate air quality and climate predictions. As an important step toward realizing this application objective, the Geostationary Imaging Fourier Transform Spectrometer (GIFTS) Engineering Demonstration Unit (EDU) was successfully developed under the NASA New Millennium Program, 2000-2006. The GIFTS-EDU instrument employs three focal plane arrays (FPAs), which gather measurements across the long-wave IR (LWIR), short/mid-wave IR (SMWIR), and visible spectral bands. The raw GIFTS interferogram measurements are radiometrically and spectrally calibrated to produce radiance spectra, which are further processed to obtain atmospheric profiles via retrieval algorithms. The radiometric calibration is achieved using internal blackbody calibration references at ambient (260 K) and hot (286 K) temperatures. The absolute radiometric performance of the instrument is affected by several factors including the FPA off-axis effect, detector/readout electronics induced nonlinearity distortions, and fore-optics offsets. The GIFTS-EDU, being the very first imaging spectrometer to use ultra-high speed electronics to readout its large area format focal plane array detectors, operating at wavelengths as large as 15 microns, possessed non-linearity's not easily removable in the initial calibration process. In this paper, we introduce a refined calibration technique that utilizes Principle Component (PC) analysis to compensate for instrument distortions and artifacts remaining after the initial radiometric calibration process, thus, further enhance the absolute calibration accuracy. This method is

  5. Evaluation of the biological activities of crude extracts from patagonian prosopis seeds and some of their active principles.

    Mazzuca, M; Kraus, W; Balzaretti, V


    Extracts of different polarities from three species and three varieties of the genera Prosopis: P. alpataco, P. denudans var. denudans, P. denudans var. patagonica, and P. denudans var. stenocarpa, were screened in order to evaluate their antibacterial, antifungal, antifeedant, antihelminthic, molluscicidal and toxic activities. The extractions of the plant materials were carried out successively with petroleum ether, dichloromethane, ethyl acetate, methanol and water. All petroleum ether extracts showed antibacterial activity. The dichloromethane extract of P. alpataco showed antibacterial and antifungal activities. Methanol and aqueous extracts of P. denudans var. denudans and P. denudans var. patagonica showed antifungal activities and a slight response to the toxicity test. Fatty acids and a group of pentacyclic triterpenes were identified as responsible for antibacterial activities in some of the active extracts.

  6. An Industry-Equilibrium Analysis of the LeChatelier Principle

    Bache, Peter Arendorf; Laugesen, Anders

    By considering firms operating in a perfectly- or monopolisticallycompetitive industry with free entry, we show that well-established results on the celebrated LeChatelier principle (LCP) do not extend into an endogenous competitive environment. For instance, labour demand may be more elastic...

  7. An Analysis of the Syllabic Structure of English Mute in the Light of Sonority Sequencing Principle



    Syllable is the hierarchic natural feature of a language,and there are rules of the phonological sequences of the syllabic structure.Based on the Sonority Sequencing Principle (SSP),this paper will try to discuss and analyze phonological sequences of the syllabic structure of English mutes.

  8. An Analysis of the Syllabic Structure of English Mute in the Light of Sonority Sequencing Principle



    Syllable is the hierarchic natural feature of a language,and there are rules of the phonological sequences of the syllabic structure.Based on the Sonority Sequencing Principle(SSP),this paper will try to discuss and analyze phonological sequences of the syllabic structure of English mutes.

  9. Concrescent Conversations: Generating a Cooperative Learning Experience in Principles of Management--A Postmodern Analysis

    Akan, Obasi Haki


    By taking a postmodern ontology that elevates becoming over the modern ontology of being, the author of this article proposes a theory and describes a method that teachers can use to enhance students' cooperative learning of management principles. The author asserts that the social construction of learning groups is an effect of organizing…

  10. Analysis of Characters’Utterances in Bianxingji From the Perspective of Politeness Principle

    颜寒箫; 王珏


    Bianxingji is a role-exchange reality show developed by Hunan Satellite TV. Based on Leech’s Politeness Principle, the author analyzes the actual language of Bianxingji. The author hopes this article will help the readers employ PP in daily communication to achieve a more harmonious interpersonal relationship.

  11. Analysis of Characters’ Utterances in BianxingjiFrom the Perspective of Politeness Principle

    颜寒箫; 王珏


    Bianxingji is a role-exchange reality show developed by Hunan Satellite TV.Based on Leech’s Politeness Principle,the author analyzes the actual language of Bianxingji.The author hopes this article will help the readers employ PP in daily communication to achieve a more harmonious interpersonal relationship.

  12. Using an FPLC to Promote Active Learning of the Principles of Protein Structure and Purification

    Robinson, Rebekah L.; Neely, Amy E.; Mojadedi, Wais; Threatt, Katie N.; Davis, Nicole Y.; Weiland, Mitch H.


    The concepts of protein purification are often taught in undergraduate biology and biochemistry lectures and reinforced during laboratory exercises; however, very few reported activities allow students to directly gain experience using modern protein purification instruments, such as Fast Protein Liquid Chromatography (FPLC). This laboratory…

  13. Magnetic resonance imaging of the active second stage of labour: Proof of principle

    Guettler, F.V.; Heinrich, A.; Rump, J.; Bucourt, M. de; Hamm, B.; Teichgraeber, U.K. [Charite University Hospital, Department of Radiology, Berlin (Germany); Schnackenburg, B. [Philips GmbH Unternehmensbereich Healthcare, Hamburg (Germany); Bamberg, C. [Charite University Hospital, Department of Obstetrics, Berlin (Germany)


    To prove that magnetic resonance imaging of foetal anatomy during the active second stage of vaginal delivery is feasible. Initially, five pregnant volunteers around the 30th week of gestation were examined in an open MRI. Based on the findings, one vaginal delivery was acquired under real-time imaging. To monitor the birth status during image acquisition, an MR-compatible wireless cardiotocography (CTG) system was built. Single-shot sequence parameters were optimised to compensate motion artefacts during labour. Safety requirements to monitor the birth process under real-time MR imaging were met. High-resolution MR images were acquired immediately before and after delivery. In one patient, TSE single-shot cinematic sequences of the active second stage of labour were obtained. All sequences were adapted to tolerate movement of the mother and infant, as well as residual noise from the CTG. Furthermore, the MR imaging during labour showed only minor image artefacts. CTG-monitored acquisition of MRI series during the active second stage of delivery is feasible. Image quality should allow various further studies to improve models for birth simulation as well as potential investigation of obstructed labour and obstetric complications. (orig.)

  14. 电磁轴承的原理与应用%Principle and Application of Active Magnetic Bearings

    严文彩; 李宏冰; 周殿莹


    The active magnetic bearing is a new supporting technology in the world,and it began to be study in the mid- 1960s.In the paper, the structure,principle,characteristics of active magetic bearings were introduced,and the developing level and tendency of the active magnetic bearing were analyzed. At last, taking methane expansion compressor in the ethylene plant as an example, matters needing attention during design,type selection and application of the active magetic bearing were discussed.%  电磁轴承技术是国际上20世纪60年代中期开始研究的一项新的支承技术。第一部分简要介绍电磁轴承的结构、原理、特点,并分析了国内外电磁轴承的发展现状及前景。第二部分,以乙烯装置的甲烷膨胀/压缩机为例,阐述了电磁轴承设计选型时的注意事项及其应用。

  15. [Ethical and legal principles for the activities of bioprospection in relation to human beings and the human genome].

    Romeo Casabona, Carlos María


    During recent decades, bioprospecting has become an important field of research, which looks for development alternatives, entry into global (environmental) markets, and the subsequent obtention of benefits under sustainable development principles. However, there is still so much to discuss regarding the social and environmental impacts produced by this activity, as well as its main limitations. To this end, the Forum/round-table discussion, entitled "Bioprospección, Etica y Sociedad" was organised to take place on 28 March 2012 at the National University of Colombia. Its main objective was to enrich our knowledge on bioprospecting considering the ethical considerations that involve society. The presentation given by Professor ROMEO CASABONA, regarding the connection between bioprospecting and the human genome deserves special attention and is presented below.

  16. Tuning the chemical activity through PtAu nanoalloying: a first principles study

    Mokkath, Junais Habeeb


    The electronic structure and adsorption properties of 1.5 nm sized Pt, Au, and PtAu nanoclusters are studied by density functional theory. We explain the recent experimental finding that 20% Au content in PtAu nanoparticles is optimal to induce a dramatically different catalytic behavior. Our results show that the d-band center together with the density of states at the Fermi energy can be used as an indicator of the chemical activity of PtAu nanoclusters. The most favorable adsorption sites on the cluster surfaces as a function of the Pt/Au ratio are identified using atomic H as a probe.

  17. Causality Principle

    Chi, Do Minh


    We advance a famous principle - causality principle - but under a new view. This principle is a principium automatically leading to most fundamental laws of the nature. It is the inner origin of variation, rules evolutionary processes of things, and the answer of the quest for ultimate theories of the Universe.

  18. An active coronagraph using a liquid crystal array for exoplanet imaging: principle and testing

    Xi Zhang; De-Qing Ren; Yong-Tian Zhu; Jiang-Pei Dou


    High-contrast imaging coronagraphs,used for the detection of exoplanets,have always adopted passive coronagraph optical components.It is therefore impossible to actively optimize the coronagraphs to achieve their best performance.To solve this problem,we propose a novel high-contrast imaging coronagraph which combines a liquid crystal array (LCA) for active pupil apodization and a deformable mirror (DM) for phase correction.The LCA we use is an amplitude-only spatial light modulator.The LCA is well calibrated and compensates for its amplitude non-uniformity and nonlinear intensity responsivity.We measured the imaging contrasts of the coronagraph system with the LCA only and without the DM deployed.Imaging contrasts of 10-4 and 10-5 can be reached at an inner working angular distance of 2.5 and 5λ/D,respectively.A simulation shows that the phase errors on the coronagraph pupil limit the contrast performance.The contrast could be further improved if a DM is deployed to correct the phase errors induced by the LCA and coronagraph optics.

  19. Investigation into the antioxidant and antidiabetic potential of Moringa stenopetala: identification of the active principles.

    Habtemariam, Solomon


    The fresh leaves of Moringa stenopetala (family, Moringaceae) are commonly eaten as cabbage while dried leaves are used as nutritional supplement and for treating a variety of disease conditions including diabetes. The present investigation into the therapeutic potential of the leaves and seeds of the plant revealed no inhibitory effect against α-glucosidase enzyme up to the concentration of 200 μg/mL but the leaves extract displayed potent DPPH (1,1-diphenyl-2- picrylhydrazyl) radical scavenging effect (IC50, 59.5 ± 4.1 μg/mL). An activity directed fractionation and isolation procedure resulted in the identification of the major antioxidant compound as rutin and minor active component, neochlorogenic acid. Both the crude extract (0.8-200 μg/mL) and rutin (0.8-200 μM) but not neochlorogenic acid displayed a concentration-dependent protection of human pancreatic β-cells (1.4E7 cells) from oxidant-induced cell death. The identification of these compounds along with their potential role in the nutritional and medicinal significance of the plant is discussed.

  20. A Principle for Describing and Verifying Brain Mechanisms Using Ongoing Activity

    Eriksson, David


    Not even the most informed scientist can setup a theory that takes all brain signals into account. A neuron not only receives neuronal short range and long range input from all over the brain but a neuron also receives input from the extracellular space, astrocytes and vasculature. Given this complexity, how does one describe and verify a typical brain mechanism in vivo? Common to most described mechanisms is that one focuses on how one specific input signal gives rise to the activity in a population of neurons. This can be an input from a brain area, a population of neurons or a specific cell type. All remaining inputs originating from all over the brain are lumped together into one background input. The division into two inputs is attractive since it can be used to quantify the relative importance of either input. Here we have chosen to extract the specific and the background input by means of recording and inhibiting the specific input. We summarize what it takes to estimate the two inputs on a single trial level. The inhibition should not only be strong but also fast and the specific input measurement has to be tailor-made to the inhibition. In essence, we suggest ways to control electrophysiological experiments in vivo. By applying those controls it may become possible to describe and verify many brain mechanisms, and it may also allow the study of the integration of spontaneous and ongoing activity, which in turn governs cognition and behavior. PMID:28174523


    宋立博; 吕恬生; 费燕琼; 袁池


    Three main basic types of locomotion for a mobile robot were introduced and the advantages and disadvantages of a legged mobile robot, a wheeled mobile robot and an articulated mobile robot were also discussed. A new type of leg-wheeled mobile robot was introduced which combines the adaptability of legged robot with the stability of wheeled robot. On the basis of the structure of the wheels, the paper described the principle of the iceskater robot developed from Roller-walker and ALDURO and its construction. The paper also established an inertia coordinate system and a wheel coordinate system, and analyzed the configuration or the posture and the related kinematic constraints of the robot according to some assumptions. Based on the motion principle, a logic-based coordinated control system and corresponded flowchart were designed. At last, taking the ice-skater robot as an example the paper expounded its application and the actual experiment proved its feasibility.

  2. First-principles analysis of anharmonic nuclear motion and thermal transport in thermoelectric materials

    Tadano, Terumasa [Department of Applied Physics, The University of Tokyo, Tokyo 113-8656 (Japan); Tsuneyuki, Shinji [Department of Physics, The University of Tokyo, Tokyo 113-0033 (Japan); Institute for Solid State Physics, The University of Tokyo, Kashiwa 277-8581 (Japan)


    We show a first-principles approach for analyzing anharmonic properties of lattice vibrations in solids. We firstly extract harmonic and anharmonic force constants from accurate first-principles calculations based on the density functional theory. Using the many-body perturbation theory of phonons, we then estimate the phonon scattering probability due to anharmonic phonon-phonon interactions. We show the validity of the approach by computing the lattice thermal conductivity of Si, a typical covalent semiconductor, and selected thermoelectric materials PbTe and Bi{sub 2}Te{sub 3} based on the Boltzmann transport equation. We also show that the phonon lifetime and the lattice thermal conductivity of the high-temperature phase of SrTiO{sub 3} can be estimated by employing the perturbation theory on top of the solution of the self-consistent phonon equation.

  3. The 1967 Arab-Israeli Six-Day War: An Analysis Using the Principles of War


    10 Chaim Herzog, The Arab-Israeli Wars, (New York: Vintage Books, 1984), p. 154. 11 Ibid, p. 154. 12 Nadav Safran , Israel-The Embattled Ally...13 Herzog, p. 156. 14 Herzog, p. 154. 15 Safran , p. 246. 16 Dupuy, p. 1231. 17 Safran , p. 248. 8 The Israeli ground offensive, on this front...236. 22 Herzog, p. 184. 23 Safran , p. 256. 10 principles of war provide a useful template in analyzing a conflict. The definitions and descriptions of

  4. The principle analysis of methane explosion suppressed by water column curtain in coal mining

    ZHOU Tong-ling(周同龄); HE Xue-qiu(何学秋); YANG Yi(杨艺)


    The principles of fine water mist explosion-extinguishing system was introduced. The defects of current systems were analyzed. The concept of a new water column curtain and the explosion-extinguishing mechanism were given. Using water column curtain to suppress methane explosion in experiment pipes was conducted. The photos were written with schlieren photograph system. The results of experiment show that the effect is perfect.

  5. Analysis on Humor of Situation Comedy My Own Swordsman by Politeness Principles



    Humor, as a linguistic phenomenon, appeals more and more attention from linguist, psychologist, sociologist, and the scholars of other disciplines. This paper, takes the humorous language of My Own Swordsman as research material, which contain⁃ing the depiction of trivial daily life, the meaning of life. Then, the author analyzed these data and discussed its features of humor from Pragmatic view by Leech and Levinson’s politeness principle.

  6. Bioassay-Guided Fractionation of a Leaf Extract from Combretum mucronatum with Anthelmintic Activity: Oligomeric Procyanidins as the Active Principle.

    Spiegler, Verena; Sendker, Jandirk; Petereit, Frank; Liebau, Eva; Hensel, Andreas


    Combretum mucronatum Schumach. & Thonn. is a medicinal plant widely used in West African traditional medicine for wound healing and the treatment of helminth infections. The present study aimed at a phytochemical characterization of a hydroalcoholic leaf extract of this plant and the identification of the anthelmintic compounds by bioassay-guided fractionation. An EtOH-H2O (1:1) extract from defatted leaves was partitioned between EtOAc and H2O. Further fractionation was performed by fast centrifugal partition chromatography, RP18-MPLC and HPLC. Epicatechin (1), oligomeric proanthocyanidins (OPC) 2 to 10 (mainly procyanidins) and flavonoids 11 to 13 were identified as main components of the extract. The hydroalcoholic extract, fractions and purified compounds were tested in vitro for their anthelmintic activity using the model nematode Caenorhabditis elegans. The bioassay-guided fractionation led to the identification of OPCs as the active compounds with a dose-dependent anthelmintic activity ranging from 1 to 1000 μM. Using OPC-clusters with a defined degree of polymerization (DP) revealed that a DP ≥ 3 is necessary for an anthelmintic activity, whereas a DP > 4 does not lead to a further increased inhibitory effect against the helminths. In summary, the findings rationalize the traditional use of C. mucronatum and provide further insight into the anthelmintic activity of condensed tannins.

  7. Bioassay-Guided Fractionation of a Leaf Extract from Combretum mucronatum with Anthelmintic Activity: Oligomeric Procyanidins as the Active Principle

    Verena Spiegler


    Full Text Available Combretum mucronatum Schumach. & Thonn. is a medicinal plant widely used in West African traditional medicine for wound healing and the treatment of helminth infections. The present study aimed at a phytochemical characterization of a hydroalcoholic leaf extract of this plant and the identification of the anthelmintic compounds by bioassay-guided fractionation. An EtOH-H2O (1:1 extract from defatted leaves was partitioned between EtOAc and H2O. Further fractionation was performed by fast centrifugal partition chromatography, RP18-MPLC and HPLC. Epicatechin (1, oligomeric proanthocyanidins (OPC 2 to 10 (mainly procyanidins and flavonoids 11 to 13 were identified as main components of the extract. The hydroalcoholic extract, fractions and purified compounds were tested in vitro for their anthelmintic activity using the model nematode Caenorhabditis elegans. The bioassay-guided fractionation led to the identification of OPCs as the active compounds with a dose-dependent anthelmintic activity ranging from 1 to 1000 μM. Using OPC-clusters with a defined degree of polymerization (DP revealed that a DP ≥ 3 is necessary for an anthelmintic activity, whereas a DP > 4 does not lead to a further increased inhibitory effect against the helminths. In summary, the findings rationalize the traditional use of C. mucronatum and provide further insight into the anthelmintic activity of condensed tannins.

  8. QSAR prediction of estrogen activity for a large set of diverse chemicals under the guidance of OECD principles.

    Liu, Huanxiang; Papa, Ester; Gramatica, Paola


    A large number of environmental chemicals, known as endocrine-disrupting chemicals, are suspected of disrupting endocrine functions by mimicking or antagonizing natural hormones, and such chemicals may pose a serious threat to the health of humans and wildlife. They are thought to act through a variety of mechanisms, mainly estrogen-receptor-mediated mechanisms of toxicity. However, it is practically impossible to perform thorough toxicological tests on all potential xenoestrogens, and thus, the quantitative structure--activity relationship (QSAR) provides a promising method for the estimation of a compound's estrogenic activity. Here, QSAR models of the estrogen receptor binding affinity of a large data set of heterogeneous chemicals have been built using theoretical molecular descriptors, giving full consideration to the new OECD principles in regulation for QSAR acceptability, during model construction and assessment. An unambiguous multiple linear regression (MLR) algorithm was used to build the models, and model predictive ability was validated by both internal and external validation. The applicability domain was checked by the leverage approach to verify prediction reliability. The results obtained using several validation paths indicate that the proposed QSAR model is robust and satisfactory, and can provide a feasible and practical tool for the rapid screening of the estrogen activity of organic compounds.

  9. Active principles of Grindelia robusta exert antiinflammatory properties in a macrophage model.

    La, Vu Dang; Lazzarin, Francesco; Ricci, Donata; Fraternale, Daniele; Genovese, Salvatore; Epifano, Francesco; Grenier, Daniel


    Plant extracts and/or secondary metabolites are receiving considerable attention as therapeutic agents for treating inflammatory diseases such as periodontitis, which affects the tooth supporting tissues. The aim of this study was to investigate the effect of a Grindelia robusta extract enriched in saponins and polyphenols on Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS)-induced inflammatory mediator (IL-6, TNF-a, RANTES, MCP-1, PGE(2) ) and matrix metalloproteinase (MMP-1, -3, -7, -8, -9, -13) secretion by macrophages. LPS induced a marked increase in the secretion of all inflammatory mediators and MMPs tested by macrophages, as determined by enzyme-linked immunosorbent assays. At non-cytotoxic concentrations, the G. robusta extract inhibited dose-dependently the secretion of IL-6, RANTES, MCP-1 and, to a lesser extent, PGE(2) and TNF-a. Such inhibition was also observed for MMP-1, -3, -7, -8, -9 and -13 secretion. This ability of G. robusta extract to reduce the LPS-induced secretion of inflammatory mediators and MMPs was associated with a reduction of nuclear factor-kappa B (NF-kB) p65 activation. The results suggest that G. robusta extract possesses an antiinflammatory therapeutic potential through its capacity to reduce the accumulation of inflammatory mediators and MMPs.

  10. Ameliorative Effect of Active Principle Isolated from Seeds of Eugenia jambolana on Carbohydrate Metabolism in Experimental Diabetes

    Suman Bala Sharma


    Full Text Available The aim of this study was to evaluate the antidiabetic activity of LH II purified from ethanolic seed extract of Eugenia jambolana in alloxan-induced mild diabetic (MD and severely diabetic (SD rabbits. Ethanolic extract upon chromatographic purification yielded partially purified hypoglycemic principle (SIII which on further purification by sephadex LH 20 yielded pharmacological active compound LH II. Homogeneity of LH II was tested by HPLC. Phytochemical investigation of LH II by various structural spectra showed the presence of saturated fatty acid, Δ5 lipid and presence of sterol. LH II was administered orally at a dose of 10 mg kg−1 body weight to MD and SD. LH II resulted, significant fall in FBG at 90 min (21.2% MD: 28.6% SD, 7th day (35.6% MD and 15th day (59.6% SD. Glycosylated hemoglobin was significantly decreased (50.5% in SD after 15 days treatment (Tt. Plasma insulin levels were significantly increased (P <  .001. In vitro studies with pancreatic islets showed 3-fold increase in insulin levels as compared to untreated animals. LH II also showed extrapancreatic effect by significantly increasing (P <  .001 the activity of key enzymes of glycolysis and significantly decreasing (P <  .001 the activity of key enzymes of gluconeogenesis. Liver and muscle glycogen content were increased by 36.6 and 30% for MD, and 52 and 47% for SD, respectively. Thus, the present study demonstrates that LH II possesses potent antidiabetic activity and it is effective in both MD and SD rabbits.

  11. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K.

    Kim, Ji Ho; Son, Yeon Kyung; Kim, Gun Hee; Hwang, Keum Hee


    Monoamine oxidase inhibitors (MAOI) have been widely used as antidepressants. Recently, there has been renewed interest in MAO inhibitors. The activity-guided fractionation of extracts from Angelica keiskei Koidzumi (A. keiskei K.) led to the isolation of two prenylated chalcones, xanthoangelol and 4-hydroxyderricin and a flavonoid, cynaroside. These three isolated compounds are the major active ingredients of A. keiskei K. to inhibit the MAOs and DBH activities. Xanthoangelol is a nonselective MAO inhibitor, and a potent dopamine β-hydroxylase (DBH) inhibitor. IC50 values of xanthoangelol to MAO-A and MAO-B were calculated to be 43.4 μM, and 43.9 μM. These values were very similar to iproniazid, which is a nonselective MAO inhibitor used as a drug against depression. The IC50 values of iproniazid were 37 μM, and 42.5 μM in our parallel examination. Moreover, IC50 value of xanthoangelol to DBH was calculated 0.52 μM. 4-Hydroxyderricin is a potent selective MAO-B inhibitor and also mildly inhibits DBH activity. The IC50 value of 4-hydroxyderricin to MAO-B was calculated to be 3.43 μM and this value was higher than that of deprenyl (0.046 μM) used as a positive control for selective MAO-B inhibitor in our test. Cynaroside is a most potent DBH inhibitor. The IC50 value of cynaroside to DBH was calculated at 0.0410 μM. Results of this study suggest that the two prenylated chalcones, xanthoangelol and 4-hydroxyderricin isolated from A. keiskei K., are expected for potent candidates for development of combined antidepressant drug. A. keiskei K. will be an excellent new bio-functional food material that has the combined antidepressant effect.

  12. [Protection of genetic data in Spain. Analysis based on the general principles of personal data protection].

    García Amez, Javier


    The genetic data is Spain is not regulated specifically, rather, we must look at the regulation on the protection of data of a personal nature. This is turn, establishes a series of general principles to apply to any type of data. Analysing this with other regulations that are dispersed both in the national and international regulations, we can deduce the rights and obligations in this field. This highlights the fact that one can't dispose of the genetic data in the same manner as the personal data.

  13. Survival analysis of stochastic competitive models in a polluted environment and stochastic competitive exclusion principle.

    Liu, Meng; Wang, Ke; Wu, Qiong


    Stochastic competitive models with pollution and without pollution are proposed and studied. For the first system with pollution, sufficient criteria for extinction, nonpersistence in the mean, weak persistence in the mean, strong persistence in the mean, and stochastic permanence are established. The threshold between weak persistence in the mean and extinction for each population is obtained. It is found that stochastic disturbance is favorable for the survival of one species and is unfavorable for the survival of the other species. For the second system with pollution, sufficient conditions for extinction and weak persistence are obtained. For the model without pollution, a partial stochastic competitive exclusion principle is derived.

  14. [The principle and analysis of micro-Fourier transform spectrometer based on MEMS micro-mirror].

    Chen, Jian-Jun; Zhu, Yong; Liu, Bo; Wei, Wei; Zhang, Jie; Wang, Ning


    The present paper puts forward a novel micro-Fourier transform infrared spectrometer based on programmable MEMS micro-mirror. This design uses a MEMS micro-mirror and a slantwise reflector to replace the moving mirror system on traditional spectrometer. This paper analyzes the operating principle of this spectrometer and gives the simulation result to prove the feasibility of this method. The results show that the spectral resolution is less than 5 nm in near-infrared wave band, the wave-length accuracy is approximately 1 nm and the sampling period of this spectrometer is approximately 50 ms. This method can use Hadamard transform to improve the SNR.

  15. A Theoretical Analysis of Polluter-Pays Principle with ‘Allocated Costs’ between Economic Agents

    小出 秀雄; コイデ ヒデオ; Koide, Hideo


    The aim of this paper is to clarify both original and extended definitions of “Polluter-Pays Principle,” point out the shortcomings of the theoretical analysis frequently used in environmental economics, and then build a simple general equilibrium model showing several ways of internalizing social costs emerged by pollution from production of goods, with an introduction of so called “allocated costs” between economic agents concerned. This is an economic attempt to determine whether the Pollu...

  16. In Vivo Anti-Trypanosoma cruzi Activity of Hydro-Ethanolic Extract and Isolated Active Principles from Aristeguietia glutinosa and Mechanism of Action Studies

    Javier Varela


    Full Text Available The currently available treatments for Chagas disease show limited therapeutic potential and are associated with serious side effects. Attempting to find alternative drugs isolated from Nature as agents against Trypanosoma cruzi has been our goal. Recently, we have demonstrated the in vitro anti-T. cruzi activities of two secondary metabolites isolated from the hydro-ethanolic extract of the aerial parts of Aristeguietia glutinosa (Lam., (family Asteraceae. These active principles displayed poor hemolytic activity, low toxicity against murine macrophages, and absence of mutagenicity. Herein, proof of concept in vivo studies of the whole hydro-ethanolic extract of the aerial parts of Aristeguietia glutinosa and of the most active component isolated from the hydro-ethanolic extract, i.e., (+-15-hydroxy-7-labden-17-al, was done in a murine acute model of Chagas disease. Both treatments caused a decrease in the animals’ parasitemia. Metabolomic mechanism of action studies were done by 1H-NMR, both on the extract and on the active compounds, examining the effects of the metabolites both on membrane sterol biosynthesis and mitochondrial dehydrogenases, whereby we found that one of the metabolites inhibited the activity of the parasite mitochondrial dehydrogenases and the other inhibited the biosynthesis of parasite membrane sterols. The results are interesting in the context of popular use of plants for the treatment of Chagas disease.

  17. Is the log-law a first principle result from Lie-group invariance analysis?

    Frewer, Michael; Foysi, Holger


    The invariance method of Lie-groups in the theory of turbulence carries the high expectation of being a first principle method for generating statistical scaling laws. The purpose of this comment is to show that this expectation has not been met so far. In particular for wall-bounded turbulent flows, the prospects for success are not promising in view of the facts we will present herein. Although the invariance method of Lie-groups is explicitly able to generate statistical scaling laws for wall-bounded turbulent flows, like the log-law for example, these invariant results yet not only fail to fulfil the basic requirements for a first principle result, but also are strongly misleading. The reason is that not the functional structure of the log-law itself is misleading, but that its invariant Lie-group based derivation yielding this function is what is misleading. By revisiting the study of Oberlack (2001) [Oberlack, M., 2001. A unified approach for symmetries in plane parallel turbulent shear flows. J. Fluid ...

  18. Interaction Analysis and Decomposition Principle for Control Structure Design of Large-scale Systems

    罗雄麟; 刘雨波; 许锋


    Industrial processes are mostly large-scale systems with high order. They use fully centralized control strategy, the parameters of which are difficult to tune. In the design of large-scale systems, the decomposition ac-cording to the interaction between input and output variables is the first step and the basis for the selection of con-trol structure. In this paper, the decomposition principle of processes in large-scale systems is proposed for the de-sign of control structure. A new variable pairing method is presented, considering the steady-state information and dynamic response of large-scale system. By selecting threshold values, the related matrix can be transformed into the adjoining matrixes, which directly measure the couple among different loops. The optimal number of controllers can be obtained after decomposing the large-scale system. A practical example is used to demonstrate the validity and feasibility of the proposed interaction decomposition principle in process large-scale systems.

  19. Active vision in satellite scene analysis

    Naillon, Martine


    In earth observation or planetary exploration it is necessary to have more and, more autonomous systems, able to adapt to unpredictable situations. This imposes the use, in artificial systems, of new concepts in cognition, based on the fact that perception should not be separated from recognition and decision making levels. This means that low level signal processing (perception level) should interact with symbolic and high level processing (decision level). This paper is going to describe the new concept of active vision, implemented in Distributed Artificial Intelligence by Dassault Aviation following a 'structuralist' principle. An application to spatial image interpretation is given, oriented toward flexible robotics.

  20. An Analysis of Chapter XXXI of Oliver Twist From the Perspective of the Violating of Cooperative Principle

    Xu Xiaojuan


    Oliver Twist, or The Parish Boy’s Progress (1837), one of Charles Dickens’s masterpieces, has occupied an important position in literature. As a classical work,Oliver Twist has enjoyed great popularity since its publication. Charles Dickens describes, in this work, the tragic life and experiences of the orphan boyOliver Twist who was born in an inhuman workhouse and cruelly treated there in his childhood. This paper attempts to make a detailed analysis of chapter XXXI ofOliver Twist from the perspective of the violating of Cooperative Principle.

  1. Active and Principled

    wang yi


    Reuters: The fourth foreign ministers' meet- ing of the ISSG held yesterday [February 11] had achieved some breakthroughs. However, in the situation that Russia is still carrying out military strikes against Syria, do you think the outcomes of this foreign ministers' meeting will bring about changes in the situation on the ground in Syria?

  2. Structural analysis of char by Raman spectroscopy: Improving band assignments through computational calculations from first principles

    Smith, Matthew W.; Dallmeyer, Ian; Johnson, Timothy J.; Brauer, Carolyn S.; McEwen, Jean-Sabin; Espinal, Juan F.; Garcia-Perez, Manuel


    Raman spectroscopy is a powerful tool for the characterization of many carbon 27 species. The complex heterogeneous nature of chars and activated carbons has confounded 28 complete analysis due to the additional shoulders observed on the D-band and high intensity 29 valley between the D and G-bands. In this paper the effects of various vacancy and substitution 30 defects have been systematically analyzed via molecular modeling using density functional 31 theory (DFT) and how this is manifested in the calculated gas-phase Raman spectra. The 32 accuracy of these calculations was validated by comparison with (solid-phase) experimental 33 spectra, with a small correction factor being applied to improve the accuracy of frequency 34 predictions. The spectroscopic effects on the char species are best understood in terms of a 35 reduced symmetry as compared to a “parent” coronene molecule. Based upon the simulation 36 results, the shoulder observed in chars near 1200 cm-1 has been assigned to the totally symmetric 37 A1g vibrations of various small polyaromatic hydrocarbons (PAH) as well as those containing 38 rings of seven or more carbons. Intensity between 1400 cm-1 and 1450 cm-1 is assigned to A1g 39 type vibrations present in small PAHs and especially those containing cyclopentane rings. 40 Finally, band intensity between 1500 cm-1 and 1550 cm-1 is ascribed to predominately E2g 41 vibrational modes in strained PAH systems. A total of ten potential bands have been assigned 42 between 1000 cm-1 and 1800 cm-1. These fitting parameters have been used to deconvolute a 43 thermoseries of cellulose chars produced by pyrolysis at 300-700 °C. The results of the 44 deconvolution show consistent growth of PAH clusters with temperature, development of non-45 benzyl rings as temperature increases and loss of oxygenated features between 400 °C and 46 600 °C

  3. Analysis of Verbal Humor in IPARTMENT3 from the Perspective of Cooperative Principle



    This paper will adopt Cooperative Principle to analyze the ut erances randomly picked from Chinese sitcom IPARTMENT3, which will help us further appreciate humor in IPARTMENT3 and use the language bet er in conversation in the near future.%本文从语用学合作原则的角度出发,以情景喜剧《爱情公寓3》中丰富的语料为例,研究在会话中违反合作原则之后所产生的会话含义及其产生的幽默。旨在帮助我们更好地欣赏《爱情公寓3》中的幽默话语和今后更好的运用语言。

  4. Research on transmission principle and kinematics analysis for involute spherical gear

    PAN Cun-yun; WEN Xi-sen; YANG Kun-yu; XU Xiao-jun; LIU Min; YAO Qi-shui


    A new kind of transmission-type spherical gear called 'ring involute spherical gear mechanism' is introduced.Compared to the famous TRALLFA spherical gear,this new spherical gear has an involute tooth profile,and a ring tooth that is distributed continuously on the surface of the sphere.This allows the gear to overcome two disadvantages of the TRALLFA spherical gear:the drive principle error and the manufacturing difficulty.The new transmission and the formation principle of the tooth's surface of the new spherical gear mechanism are first introduced,then another mechanism,called disk rack,is introduced,which is derived from the spherical gear mechanism when one of the spherical gear's tooth number reaches infinity.To make the research more convenient,every part of the new spherical gear mechanism is named.In the following sections,some problems are discussed,such as the assembly form,the construction characteristics,the correct meshing condition,the continuum transmission condition and so on.Furthermore,the paper deduces the surface formula of the conjugate teeth profiles,which proves that the conjugate teeth profiles is also one of the ringed involute spherical gear.In order to analyze the relationship between two coordinate systems,which is attached respectively to the diving spherical gear and the driven spherical gear,the orientation cosine matrix method is utilized.By series rotational transformation, the kinematics model and inverse kinematics model are deduced.Using the method for calculating the transmission ratio of planet gear train,the relationship of the two oscillating angle between output axis and the bracket is established.Based on the research,the kinematics graphic simulation of spherical gear mechanism and disk rack are made respectively.The results prove correctness of the kinematics model.

  5. Software citation principles

    Arfon M. Smith


    Full Text Available Software is a critical part of modern research and yet there is little support across the scholarly ecosystem for its acknowledgement and citation. Inspired by the activities of the FORCE11 working group focused on data citation, this document summarizes the recommendations of the FORCE11 Software Citation Working Group and its activities between June 2015 and April 2016. Based on a review of existing community practices, the goal of the working group was to produce a consolidated set of citation principles that may encourage broad adoption of a consistent policy for software citation across disciplines and venues. Our work is presented here as a set of software citation principles, a discussion of the motivations for developing the principles, reviews of existing community practice, and a discussion of the requirements these principles would place upon different stakeholders. Working examples and possible technical solutions for how these principles can be implemented will be discussed in a separate paper.

  6. Conference on Instrumental Activation Analysis: IAA 89

    Vobecky, M.; Obrusnik, I.


    The proceedings contain 40 abstracts of papers all of which have been incorporated in INIS. The papers were centred on the applications of radioanalytical methods, especially on neutron activation analysis, x ray fluorescence analysis, PIXE analysis and tracer techniques in biology, medicine and metallurgy, measuring instruments including microcomputers, and data processing methods.

  7. Evaluation of the structural determinants of polymeric precipitation inhibitors using solvent shift methods and principle component analysis.

    Warren, Dallas B; Bergström, Christel A S; Benameur, Hassan; Porter, Christopher J H; Pouton, Colin W


    The presence of polymers within solid dose forms, such as solid dispersions, or liquid or semisolid formulations, such as lipid-based formulations, can promote the maintenance of drug supersaturation after dissolution or dispersion/digestion of the vehicle in the gastrointestinal tract. Transiently stable supersaturation delays precipitation, increases thermodynamic activity, and may enhance bioavailability and reduce variability in exposure. In the current study a diverse range of 42 different classes of polymers, with a total of 78 polymers across all classes, grades, and molecular weights were examined, to varying degrees, as potential polymeric precipitation inhibitors (PPIs) using a solvent shift method to initiate supersaturation. To provide a deeper understanding of the molecular determinants of polymer utility the data were also analyzed, along with a range of physicochemical descriptors of the polymers employed, using principle component analysis (PCA). Polymers were selectively tested for their ability to stabilize supersaturation for nine poorly water-soluble model drugs, representing a range of nonelectrolytes, weak acids, and weak bases. In general, the cellulose-based polymers (and in particular hydroxypropylmethyl cellulose, HPMC, and its derivatives) provided robust precipitation inhibition across most of the drugs tested. Subsequent PCA indicate that there is consistent PPI behavior of a given polymer for a given drug type, with clear clustering of the performance of polymers with each of the nonelectrolytes, weak bases, and weak acids. However, there are some exceptions to this, with some specific drug type-polymer interactions also occurring. Polymers containing primary amine functional groups should be avoided as they are prone to enhancing precipitation rates. An inverse relationship was also documented for the number of amide, carboxylic acid, and hydroxyl functional groups; therefore for general good PPI performance the number of these

  8. Screening of promising chemotherapeutic candidates against human adult T-cell leukemia/lymphoma from plants: active principles from Physalis pruinosa and structure-activity relationships with withanolides.

    Nakano, Daisuke; Ishitsuka, Kenji; Hatsuse, Takahiro; Tsuchihashi, Ryota; Okawa, Masafumi; Okabe, Hikaru; Tamura, Kazuo; Kinjo, Junei


    Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy caused by human T-cell lymphotropic virus type I (HTLV-1). Clinical manifestations of ATL range from smoldering to chronic, lymphoma and acute subtypes. Patients with acute and lymphoma-type ATL require therapeutic intervention. Conventional chemotherapeutic regimens used against other malignant lymphoma have been administered to ATL patients, but the therapeutic outcomes of acute and lymphoma-type ATL remain very poor. In this study, 214 extracts from 162 plants belonging to 65 families were screened for the purpose of elucidating the anti-proliferative effect against HTLV-1-infected T-cell lines. Extracts from aerial parts of Physalis pruinosa showed potent inhibitory effect. We isolated five withanolides from the extracts by activity-guided fractionation and examined the structure-activity relationships. The presence of a 5β,6β-epoxy function is suggested to be essential for the activity, and the most active principle showed selective toxicity to HTLV-1-infected T-cell lines.

  9. Development of a NIR-based blend uniformity method for a drug product containing multiple structurally similar actives by using the quality by design principles.

    Lin, Yiqing; Li, Weiyong; Xu, Jin; Boulas, Pierre


    The aim of this study is to develop an at-line near infrared (NIR) method for the rapid and simultaneous determination of four structurally similar active pharmaceutical ingredients (APIs) in powder blends intended for the manufacturing of tablets. Two of the four APIs in the formula are present in relatively small amounts, one at 0.95% and the other at 0.57%. Such small amounts in addition to the similarity in structures add significant complexity to the blend uniformity analysis. The NIR method is developed using spectra from six laboratory-created calibration samples augmented by a small set of spectra from a large-scale blending sample. Applying the quality by design (QbD) principles, the calibration design included concentration variations of the four APIs and a main excipient, microcrystalline cellulose. A bench-top FT-NIR instrument was used to acquire the spectra. The obtained NIR spectra were analyzed by applying principal component analysis (PCA) before calibration model development. Score patterns from the PCA were analyzed to reveal relationship between latent variables and concentration variations of the APIs. In calibration model development, both PLS-1 and PLS-2 models were created and evaluated for their effectiveness in predicting API concentrations in the blending samples. The final NIR method shows satisfactory specificity and accuracy.

  10. Structural and mechanical properties of alkali hydrides investigated by the first-principles calculations and principal component analysis

    Settouti, Nadera; Aourag, Hafid


    The structural and mechanical properties of alkali hydrides (LiH, NaH, KH, RbH, and CsH) were investigated via first-principles calculations which cover the optimized structural parameters. The density functional theory in combination with the generalized gradient approximation (GGA) were used in this study. From the present study, one could note that alkali hydrides are brittle materials and mechanically stable. It was found that stiffness and shear resistance are greater in LiH than in other hydrides. It is more brittle in nature, and comparatively harder than the other materials under study; it also presents a high degree of anisotropy. The results were then investigated and analyzed with principal component analysis (PCA), which is one of the most common techniques in multivariate analysis, was used to explore the correlations among material properties of alkali hydrides and to study their trends. The alkali hydrides obtained by the first-principles calculations were also compared with the alkaline-earth metal hydrides (BeH2, MgH2, CaH2, SrH2, and BaH2) and discussed in this work.

  11. 老年人在城市体育公园中的活动类型及设计原则%Design Principles and Types of Activities of Elderly in City Sports Park

    孙小茜; 周萌


    Through the analysis on the activity types of the elderly in the city sports park, the author deeply discusses the design principle of the city sports park, aiming at creating a more comfortable, healthy, safe recreational activity space for the aged.%本文通过对城市体育公园中老年人活动类型的分析,深入探讨了城市体育公园的设计原则,旨在为老年人营造一个更加舒适、健康、安全的娱乐活动空间。

  12. Sociosexuality Education for Persons with Autism Spectrum Disorders Using Principles of Applied Behavior Analysis

    Wolfe, Pamela S.; Condo, Bethany; Hardaway, Emily


    Applied behavior analysis (ABA) has emerged as one of the most effective empirically based strategies for instructing individuals with autism spectrum disorders (ASD). Four ABA-based strategies that have been found effective are video modeling, visual strategies, social script fading, and task analysis. Individuals with ASD often struggle with…

  13. Understanding Lithium Solvation and Diffusion through Topological Analysis of First-Principles Molecular Dynamics

    Bhatia, Harsh [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gyulassy, Attila [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Ong, Mitchell [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lordi, Vincenzo [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Draeger, Erik [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Pask, John [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Pascucci, Valerio [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Bremer, Peer -Timo [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)


    The performance of lithium-ion batteries is strongly influenced by the ionic conductivity of the electrolyte, which depends on the speed at which Li ions migrate across the cell and relates to their solvation structure. The choice of solvent can greatly impact, both, the solvation and diffusivity of Li ions. In this work, we present our application of the topological techniques to extract and predict such behavior in the data generated by the first-principles molecular dynamics simulation of Li ions in an important organic solvent -ethylene carbonate. More specifically, we use the scalar topology of the electron charge density field to analyze the evolution of the solvation structures. This allows us to derive a parameter-free bond definition for lithium-oxygen bonds, to provide a quantitative measure for bond strength, and to understand the regions of influence of each atom in the simulation. This has provided new insights into how and under what conditions certain bonds may form and break. As a result, we can identify and, more importantly, predict, unstable configurations in solvation structures. This can be very useful in understanding when small changes to the atoms' movements can cause significantly different bond structures to evolve. Ultimately, this promises to allow scientists to explore lithium ion solvation and diffusion more systematically, with the aim of new insights and potentially accelerating the calculations themselves.

  14. An Action Principle for an Interacting Fermion System and its Analysis in the Continuum Limit

    Finster, Felix


    We introduce and analyze a system of relativistic fermions in a space-time continuum, which interact via an action principle as previously considered in a discrete space-time. The model is defined by specifying the vacuum as a sum of Dirac seas corresponding to several generations of elementary particles. The only free parameters entering the model are the fermion masses. We find dynamical field equations if and only if the number of generations equals three. In this case, the dynamics is described by a massive axial potential coupled to the Dirac spinors. The coupling constant and the rest mass of the axial field depend on the regularization; for a given regularization method they can be computed as functions of the fermion masses. The bosonic mass term arises as a consequence of a symmetry breaking effect, giving an alternative to the Higgs mechanism. In addition to the standard loop corrections of quantum field theory, we find new types of correction terms to the field equations which violate causality. Th...

  15. Numerical analysis on heat transfer enhancement by longitudinal vortex based on field synergy principle

    WU Junmei; TAO Wenquan


    Three-dimensional numerical simulation results are presented for a fin-and-tube heat transfer surface with vortex generators.The effects of the Reynolds number (from 800 to 2 000) and the attack angle (30° and 45°) of a delta winglet vortex generator are examined.The numerical results are analyzed on the basis of the field synergy principle to explain the inherent mechanism of heat transfer enhancement by longitudinal vortex.The secondary flow generated by the vortex generators causes the reduction of the intersection angle between the velocity and fluid temperature gradients.In addition,the computational evaluations indicate that the heat transfer enhancement of delta winglet pairs for an aligned tube bank fin-and-tube surface is more significant than that for a staggered tube bank fin-and-tube surface.The heat transfer enhancement of the delta winglet pairs with an attack angle of 45° is larger than that with an angle of 30°.The delta winglet pair with an attack angle of 45° leads to an increase in pressure drop,while the delta winglet pair with the 30°angle results in a slight decrease.The heat transfer enhancement under identical pumping power condition for the attack angle of 30° is larger than that for the attack angle of 45°either for staggered or for aligned tube bank arrangement.

  16. An Analysis of Gender Differences in Pride and Prejudice from the Perspective of Politeness Principles



    This paper intends to analyze gender differences embedded in conversations of Pride and Prejudice written by the celebrated British woman writer Jane Austen.It employs gender differences in applying Cooperative Principles.It is concluded that women tend to be more polite and cooperative while men are ignorant of giving considerations for others and the smoothness of communication.By understanding this, miscommunications can be avoided, therefore effective and successful inter-gender conversations are possible to be achieved.%本文截选英国著名女作家--简·奥斯汀的巨作《傲慢与偏见》中的对话来分析两性在礼貌原则运用上的差异。通过对比分析,得出结论:对话中,女性往往较男性更擅长运用礼貌原则,她们更加礼貌、合作,男性则往往忽略周全他人感受、无暇顾及交流的通顺性。了解到这一点,就能避免男女对话中的误会与冲突问题,从而做到有效、成功的交流。

  17. Sampled-data based average consensus with measurement noises:convergence analysis and uncertainty principle

    LI Tao; ZHANG JiFeng


    In this paper,sampled-data based average-consensus control is considered for networks consisting of continuous-time first-order Integrator agents in a noisy distributed communication environment.The Impact of the sampling size and the number of network nodes on the system performances is analyzed.The control input of each agent can only use information measured at the sampling instants from its neighborhood rather than the complete continuous process,and the measurements of its neighbors'states are corrupted by random noises.By probability limit theory and the property of graph Laplacian matrix,it is shown that for a connected network,the static mean square error between the individual state and the average of the Initial states of all agents can be made arbitrarily small,provided the sampling size is sufficiently small.Furthermore,by properly choosing the consensus gains,almost sure consensus can be achieved.It is worth pointing out that an uncertainty principle of Gaussian networks is obtained,which implies that in the case of white Gausslan noises,no matter what the sampling size is,the product of the steady-state and transient performance indices is always equal to or larger than a constant depending on the noise intensity,network topology and the number of network nodes.

  18. 析萨托利“有限多数原则”%Analysis on Limited Majority Principle of Sartori



    乔万尼萨托利在《民主新论》中强调,民主的工作原则是有限的(受限制的)多数统治原则,且这一原则立足于保护少数权利以及利用少数权利限制多数的统治。同时,有限多数原则是现代民主制度的可行性原则,该文通过对简单多数原则与有限多数原则的分析,阐明了简单多数原则的含义及其存在的问题。进而通过与简单多数原则比较,分析了有限多数原则及其所具有的优点,指出了在现代民主的运行过程中有限多数原则比简单多数原则更可行。%In the book of The Theory of Democracy Revisited, Giovanni Sartori stressed that the working principle of democracy is limited or restricted majority rule which is based on the protection of minority rights and the utilization of minority rights to limit the rule of the majority. Meanwhile, limited majority rule is the feasible principle of modern democracy. Through contrastive analysis of plurality rule and limited majority rule, this paper expounds the meaning of the former and its existing problems and further analyzes the advantages of the latter in comparison to the former, and it comes down to that limited majority principle is more feasible than plurality rule in the operating process of modern democracy.

  19. Principles, Practice, and Evolution of Capillary Electrophoresis as a Tool for Forensic DNA Analysis.

    Shewale, J G; Qi, L; Calandro, L M


    Capillary electrophoresis (CE) is a versatile and widely used analysis platform with application in diverse areas such as analytical chemistry, chiral separations, clinical, forensics, molecular biology, natural products, organic chemistry, and the pharmaceutical industry. Forensic applications of CE include fragment analysis, DNA sequencing, SNP typing, and analysis of gunshot residues, explosive residues, and drugs. Fragment analysis is a widely used method for short tandem repeat (STR) profiling for human identification (HID) due to the single-base resolution capability of CE. This approach circumvents the tedious and expensive approach of DNA sequencing for STR typing. The high sizing precision, ability to detect fluorescence emitted from multiple dyes, automated electrophoretic runs, and data collection software are key factors in the worldwide adoption of CE as the preferred platform for forensic DNA analysis. The most common CE systems used in forensic DNA analysis include the ABI PRISM® 310, 3100, 3100 Avant, 3130, 3130xl, 3500, and 3500xL Genetic Analyzers (GAs). The 3500 series GAs are developed with features useful for forensic scientists, including a normalization feature for analysis of the data designed to reduce the variation in peak height from instrument to instrument and injection to injection. Other hardware and software features include improved temperature control, radio frequency identification (RFID) tags for monitoring instrument consumables, HID-focused software features, and security and maintenance.

  20. Activation analysis of meteorites. 3

    Nagai, H.; Honda, M.; Sato, H. [Nihon Univ., College of Humanities and Sciences, Tokyo (Japan); Ebihara, M.; Oura, Y.; Setoguchi, M. [Tokyo Metropolitan Univ., Faculty of Science, Tokyo (Japan)


    A long-lived cosmogenic nuclide, {sup 53}Mn in extra-terrestrial materials has been determined in the DR-1 hole of the JRR-3M reactor, applying the well-thermalized neutron flux. The neutron flux intensities are variable with the depths whereas the fast thermal ratios are not quite variable. By this method, {sup 53}Mn contents in iron meteorites and metal phases in general could be routinely determined in many samples. The chemical separation method has been modified and a convenient short circuit method has been proposed to shorten the process. The short method is to count the activities of {sup 54}Mn just after the irradiation without further purification of manganese. (author)

  1. Analysis of a bio-dynamic model via Lyapunov principle and small-world network for tuberculosis.

    Chung, H-Y; Chung, C-Y; Ou, S-C


    The study will apply Lyapunov principle to construct a dynamic model for tuberculosis (TB). The Lyapunov principle is commonly used to examine and determine the stability of a dynamic system. To simulate the transmissions of vector-borne diseases and discuss the related health policies effects on vector-borne diseases, the authors combine the multi-agent-based system, social network and compartmental model to develop an epidemic simulation model. In the identity level, the authors use the multi-agent-based system and the mirror identity concept to describe identities with social network features such as daily visits, long-distance movement, high degree of clustering, low degree of separation and local clustering. The research will analyse the complex dynamic mathematic model of TB epidemic and determine its stability property by using the popular Matlab/Simulink software and relative software packages. Facing the current TB epidemic situation, the development of TB and its developing trend through constructing a dynamic bio-mathematical system model of TB is investigated. After simulating the development of epidemic situation with the solution of the SMIR epidemic model, the authors will come up with a good scheme to control epidemic situation to analyse the parameter values of a model that influence epidemic situation evolved. The authors will try to find the quarantining parameters that are the most important factors to control epidemic situation. The SMIR epidemic model and the results via numerical analysis may offer effective prevention with reference to controlling epidemic situation of TB.

  2. A discourse analysis methodology based on semantic principles - an application to brands, journalists and consumers discourses

    Luc Grivel


    Full Text Available This is a R&D Paper. It describes an analysis coming from a research project about opinion measurement and monitoring on the Internet. This research is realized within "Paragraphe" laboratory, in partnership with the market research institute Harris Interactive (CIFRE grant beginning July 2010. The purpose of the study was to define CRM possibilities. The targets of the study were self-employed workers and very small businesses. The discourses analysis is linked to a qualitative study. It turns around three types of discourses: brands, journalists and clients’ discourses. In the brand discourses analysis we benchmarked brand websites belonging to several businesses. In this first step, we tried to identify the most used words and promises by brands to the target we were studying. For that benchmark, we downloaded "Professionals" sections of the websites. Clients’ discourses analysis is based on opened answers coming from satisfaction questionnaires. The questions we are studying have been asked after a call to a hot line or after a technician intervention. Journalists’ discourses analysis is based on articles, published on information websites specialized in Harris Interactive's client sector. These websites were chosen because we considered them to be representative of information sources, which the target could consult.

  3. Synthesis of Analogues of Gingerol and Shogaol, the Active Pungent Principles from the Rhizomes of Zingiber officinale and Evaluation of Their Anti-Platelet Aggregation Effects

    Hung-Cheng Shih


    Full Text Available The present study was aimed at discovering novel biologically active compounds based on the skeletons of gingerol and shogaol, the pungent principles from the rhizomes of Zingiber officinale. Therefore, eight groups of analogues were synthesized and examined for their inhibitory activities of platelet aggregation induced by arachidonic acid, collagen, platelet activating factor, and thrombin. Among the tested compounds, [6]-paradol (5b exhibited the most significant anti-platelet aggregation activity. It was the most potent candidate, which could be used in further investigation to explore new drug leads.

  4. Experiential and Cooperative Learning: Using a Situation Analysis Project in Principles of Marketing

    Munoz, Caroline; Huser, Ann


    In this article, the authors propose a semester-long experiential-learning project for introductory marketing students. The project requires an analysis of a product category, competition, and consumer base to support a new product proposal. The purpose is to (a) put into practice the concepts and definitions taught in an introductory marketing…

  5. Cell wall elasticity: I. A critique of the bulk elastic modulus approach and an analysis using polymer elastic principles

    Wu, H. I.; Spence, R. D.; Sharpe, P. J.; Goeschl, J. D.


    The traditional bulk elastic modulus approach to plant cell pressure-volume relations is inconsistent with its definition. The relationship between the bulk modulus and Young's modulus that forms the basis of their usual application to cell pressure-volume properties is demonstrated to be physically meaningless. The bulk modulus describes stress/strain relations of solid, homogeneous bodies undergoing small deformations, whereas the plant cell is best described as a thin-shelled, fluid-filled structure with a polymer base. Because cell walls possess a polymer structure, an alternative method of mechanical analysis is presented using polymer elasticity principles. This initial study presents the groundwork of polymer mechanics as would be applied to cell walls and discusses how the matrix and microfibrillar network induce nonlinear stress/strain relationships in the cell wall in response to turgor pressure. In subsequent studies, these concepts will be expanded to include anisotropic expansion as regulated by the microfibrillar network.

  6. Electronic and Optical Properties of Rock-Salt A1N under High Pressure via First-Principles Analysis

    ZHANG Wei; CHEN Xiang-Rong; CAI Ling-Cang; GOU Qing-Quan


    Electronic and optical properties of rock-salt A1N under high pressure are investigated by first -principles method based on the plane-wave basis set. Analysis of band structures suggests that the rock-salt AIN has an indirect gap of 4.53 eV, which is in good agreement with other results. By investigating the effects of pressure on the energy gap, the different movement of conduction band at X point below and above 22.5 GPa is predicted. The optical properties including dielectric function, absorption, reflectivity, and refractive index are also calculated and analyzed. It is found that the rock-salt AIN is transparent from the partially ultra-violet to the visible light area and hardly does the transparence affected by the pressure. Furthermore, the curve of optical spectrum will shift to high energy area (blue shift) with increasing pressure.

  7. The Design Principles of Micro-Video Production and In-Class Activi-ties on the Base of Flipped Classroom



    Flipped classroom is a brand-new teaching mode both at home and abroad. Its core is to reverse teaching sequence and teaching content by letting students watch self-made videos to learn relatively junior teaching content before class, thus leaving students adequate space to exert full activities in the classroom to complete knowledge absorption and consolidation. This article focus mainly on the design principles and relevant experiences of video production. In the meanwhile, the article also puts for-ward instructive suggestions for teachers to make appealing and stylistic videos as well as mobilize the enthusiasm of students. Video as the stepping stone only serves as a media to convey knowledge before class, the class is the core to convert students’ traditional role to be the real master by a series of effective activities, which should be carefully designed by teachers. So the sec-ond focus of the articles falls on the design principles of in-class activities.

  8. Kinematic analysis of cable-driven parallel mechanisms based on minimum potential energy principle

    Guan Liwen


    Full Text Available The forward kinematic analysis of the cable-driven parallel mechanism has been a challenging and interesting problem since 10 years ago. This work converts the forward kinematic analysis problem of the cable-driven parallel mechanism to an optimization problem, whose objective is to minimize the potential energy of mobile platform. In order to simplify the optimization problem further so that it can be solved with any simple optimization algorithm in short time, some constraints are introduced to design variables. We utilize the sequential quadratic programming algorithm to solve the simplified optimization problem in this article. The efficiency and effectiveness of the proposed approach are validated with some numerical examples. Furthermore, due to the fact that a required pose may be not stable, the availability of its inverse kinematic solution should be supervised. The aforementioned approach provides a valid tool for solving this type of problems by contrasting the distinction between the required pose and the actual pose calculated by it. The feasibility of applying our proposed method to execute the inverse kinematic analysis of cable-driven parallel mechanism is proved with several examples in this article.

  9. The Main General Didactical Principles of Glotoeducological Theory and Practice

    Regina Juškienė


    Full Text Available As a pedagogical discipline glotoeducology is related to didactics, i. e. teaching theory. Three concepts of didactics are being distinguished: teaching, teaching principles and types of teaching activity. The authors limited themselves in their paper on one of them, namely: teaching principles that determine the usage of teaching regularities in the course of implementation of the objectives of teaching and education. The article also provides analysis of interaction of linguodidactical principles with general didactical principles, the impact thereof to teaching of foreign languages.

  10. Independent component feature-based human activity recognition via Linear Discriminant Analysis and Hidden Markov Model.

    Uddin, Md; Lee, J J; Kim, T S


    In proactive computing, human activity recognition from image sequences is an active research area. This paper presents a novel approach of human activity recognition based on Linear Discriminant Analysis (LDA) of Independent Component (IC) features from shape information. With extracted features, Hidden Markov Model (HMM) is applied for training and recognition. The recognition performance using LDA of IC features has been compared to other approaches including Principle Component Analysis (PCA), LDA of PC, and ICA. The preliminary results show much improved performance in the recognition rate with our proposed method.

  11. Management principles of the interaction between market attractiveness producer and its recipients

    O.V. Sviridova


    Full Text Available The aim of the article. The article is devoted to the definition of the content of interaction between attractiveness producer and its recipients through the prism of general and derived management principles. Actuality of this article is caused by the formation of long-term relationships between business subjects. The main aim of these relationships is attracting and using of resources to further joint production and benefits distribution from these activities. Formation of such long-term relationships in condition of high competitiveness is one of the urgent problems of modern enterprises. In this regard, the traditional management principles are supplemented by the principles of the interaction and attractiveness managing. The purpose of the article is further improving of management principles through the establishment of specific management principles of the interaction between market attractiveness producer and its recipients.The results of the analysis. Management principles are the statements of fundamental truth based on logic which provides guidelines for managerial decision making and actions. The research of classic, general and structural management principles is conducted in the article. The possibility and necessity of ascertainment of the derivative management principles of interaction between subjects of market environment is noted. Derivative management principles reflect the content of the specialized management activity on forming of enterprise attractiveness. The analysis of existing management principles of different objects is conducted. It is established that as a basis for systematization of management principles scientists use different management features, such as socio-political principles, principles of management culture and state-administrative activity, socio-political, structural, scientific, legal, personnel and organizational basis.Results of research of management principles and management interaction proved

  12. Surface and Thin Film Analysis A Compendium of Principles, Instrumentation, and Applications

    Friedbacher, Gernot


    Surveying and comparing all techniques relevant for practical applications in surface and thin film analysis, this second edition of a bestseller is a vital guide to this hot topic in nano- and surface technology. This new book has been revised and updated and is divided into four parts - electron, ion, and photon detection, as well as scanning probe microscopy. New chapters have been added to cover such techniques as SNOM, FIM, atom probe (AP),and sum frequency generation (SFG). Appendices with a summary and comparison of techniques and a list of equipment suppliers make this book a rapid ref

  13. Statistical Contact Angle Analyses with the High-Precision Drop Shape Analysis (HPDSA Approach: Basic Principles and Applications

    Florian Heib


    Full Text Available Surface science, which includes the preparation, development and analysis of surfaces and coatings, is essential in both fundamental and applied as well as in engineering and industrial research. Contact angle measurements using sessile drop techniques are commonly used to characterize coated surfaces or surface modifications. Well-defined surfaces structures at both nanoscopic and microscopic level can be achieved but the reliable characterization by means of contact angle measurements and their interpretation often remains an open question. Thus, we focused our research effort on one main problem of surface science community, which is the determination of correct and valid definitions and measurements of contact angles. In this regard, we developed the high-precision drop shape analysis (HPDSA, which involves a complex transformation of images from sessile drop experiments to Cartesian coordinates and opens up the possibility of a physically meaningful contact angle calculation. To fulfill the dire need for a reproducible contact angle determination/definition, we developed three easily adaptable statistical analyses procedures. In the following, the basic principles of HPDSA will be explained and applications of HPDSA will be illustrated. Thereby, the unique potential of this analysis approach will be illustrated by means of selected examples.

  14. Analysis method and principle of dual-mode electro-mechanical variable transmission program

    Li, Hongcai; Yan, Qingdong; Xiang, Changle; Wang, Weida


    Automotive industry, as an important pillar of the national economy, has been rapidly developing in recent years. But proplems such as energy comsumption and environmental pollution are posed at the same time. Electro-mechanical variable transmission system is considered one of avilable workarounds. It is brought forward a kind of design methods of dual-mode electro-mechanical variable transmission system rotational speed characteristics and dual-mode drive diagrams. With the motor operating behavior of running in four quadrants and the speed characteristics of the simple internal and external meshing single planetary gear train, four kinds of dual-mode electro-mechanical transmission system scheme are designed. And the velocity, torque and power characteristics of one of the programs are analyzed. The magnitude of the electric split-flow power is an important factor which influences the system performance, so in the parameters matching design, it needs to reduce the power needs under the first mode of the motor. The motor, output rotational speed range and the position of the mode switching point have relationships with the characteristics design of the planetary gear set. The analysis method is to provide a reference for hybrid vehicles' design. As the involved rotational speed and torque relationships are the natural contact of every part of transmission system, a theory basis of system program and performance analysis is provided.

  15. Chemometrics Methods for Specificity, Authenticity and Traceability Analysis of Olive Oils: Principles, Classifications and Applications

    Messai, Habib; Farman, Muhammad; Sarraj-Laabidi, Abir; Hammami-Semmar, Asma; Semmar, Nabil


    Background. Olive oils (OOs) show high chemical variability due to several factors of genetic, environmental and anthropic types. Genetic and environmental factors are responsible for natural compositions and polymorphic diversification resulting in different varietal patterns and phenotypes. Anthropic factors, however, are at the origin of different blends’ preparation leading to normative, labelled or adulterated commercial products. Control of complex OO samples requires their (i) characterization by specific markers; (ii) authentication by fingerprint patterns; and (iii) monitoring by traceability analysis. Methods. These quality control and management aims require the use of several multivariate statistical tools: specificity highlighting requires ordination methods; authentication checking calls for classification and pattern recognition methods; traceability analysis implies the use of network-based approaches able to separate or extract mixed information and memorized signals from complex matrices. Results. This chapter presents a review of different chemometrics methods applied for the control of OO variability from metabolic and physical-chemical measured characteristics. The different chemometrics methods are illustrated by different study cases on monovarietal and blended OO originated from different countries. Conclusion. Chemometrics tools offer multiple ways for quantitative evaluations and qualitative control of complex chemical variability of OO in relation to several intrinsic and extrinsic factors. PMID:28231172

  16. System analysis of a piston steam engine employing the uniflow principle, a study in optimized performance

    Peoples, J. A.


    Results are reported which were obtained from a mathematical model of a generalized piston steam engine configuration employing the uniflow principal. The model accounted for the effects of clearance volume, compression work, and release volume. A simple solution is presented which characterizes optimum performance of the steam engine, based on miles per gallon. Development of the mathematical model is presented. The relationship between efficiency and miles per gallon is developed. An approach to steam car analysis and design is presented which has purpose rather than lucky hopefulness. A practical engine design is proposed which correlates to the definition of the type engine used. This engine integrates several system components into the engine structure. All conclusions relate to the classical Rankine Cycle.




    Global warming is promoted by anthropogenic CO{sub 2} emissions into the atmosphere, while at the same time it is partially mitigated by carbon sequestration by terrestrial ecosystems. However, improvement in the understanding and monitoring of below ground carbon processes is essential for evaluating strategies for carbon sequestration including quantification of carbon stores for credits. A system for non-destructive in situ carbon monitoring in soil, based on inelastic neutron scattering (INS), is described. The system can be operated in stationary or scanning mode and measures soil to depth of approximately 30 cm. There is a good agreement between results obtained from INS and standard chemical analysis of soil cores collected from the same study site.

  18. Variational principles

    Moiseiwitsch, B L


    This graduate-level text's primary objective is to demonstrate the expression of the equations of the various branches of mathematical physics in the succinct and elegant form of variational principles (and thereby illuminate their interrelationship). Its related intentions are to show how variational principles may be employed to determine the discrete eigenvalues for stationary state problems and to illustrate how to find the values of quantities (such as the phase shifts) that arise in the theory of scattering. Chapter-by-chapter treatment consists of analytical dynamics; optics, wave mecha

  19. Topological data analysis (TDA) applied to reveal pedogenetic principles of European topsoil system.

    Savic, Aleksandar; Toth, Gergely; Duponchel, Ludovic


    Recent developments in applied mathematics are bringing new tools that are capable to synthesize knowledge in various disciplines, and help in finding hidden relationships between variables. One such technique is topological data analysis (TDA), a fusion of classical exploration techniques such as principal component analysis (PCA), and a topological point of view applied to clustering of results. Various phenomena have already received new interpretations thanks to TDA, from the proper choice of sport teams to cancer treatments. For the first time, this technique has been applied in soil science, to show the interaction between physical and chemical soil attributes and main soil-forming factors, such as climate and land use. The topsoil data set of the Land Use/Land Cover Area Frame survey (LUCAS) was used as a comprehensive database that consists of approximately 20,000 samples, each described by 12 physical and chemical parameters. After the application of TDA, results obtained were cross-checked against known grouping parameters including five types of land cover, nine types of climate and the organic carbon content of soil. Some of the grouping characteristics observed using standard approaches were confirmed by TDA (e.g., organic carbon content) but novel subtle relationships (e.g., magnitude of anthropogenic effect in soil formation), were discovered as well. The importance of this finding is that TDA is a unique mathematical technique capable of extracting complex relations hidden in soil science data sets, giving the opportunity to see the influence of physicochemical, biotic and abiotic factors on topsoil formation through fresh eyes.

  20. Comparison of the Simple Cyclic Voltammetry (CV and DPPH Assays for the Determination of Antioxidant Capacity of Active Principles

    Jesús F. Arteaga


    Full Text Available Antioxidant activity of a number of small (low molecular weight natural compounds found in spices, condiments or drugs (gallic acid, sesamol, eugenol, thymol, carvacrol, vanillin, salicylaldehyde, limonene, geraniol, 4-hexylresorcinol, etc. has been evaluated using electrochemical and DPPH radical scavenging measurements. Structural analysis of the tested compound suggest a remarkable activity for phenol derivatives and the importance of the –R groups located on the phenolic ring in the molecule’s ability to act as free radical scavenging as well as their influence in the electrochemical behavior. The voltammetric method can be used for the determination of the antioxidant capability in the same manner as the DPPH radical scavenging because of the correlation found between oxidation potentials and anti-radical power (ARP = 1/EC50. Such electrochemical determination is fast and cheap and allows making measurements under a variety of experimental conditions. The accuracy of the electrochemical measurements is the same for all the compounds, irrespective of their scavenging activity, the opposite of what occurs in the DPPH test.

  1. A Principle Component Analysis of Galaxy Properties from a Large, Gas-Selected Sample

    Yu-Yen Chang


    concluded that this is in conflict with the CDM model. Considering the importance of the issue, we reinvestigate the problem using the principal component analysis on a fivefold larger sample and additional near-infrared data. We use databases from the Arecibo Legacy Fast Arecibo L-band Feed Array Survey for the gas properties, the Sloan Digital Sky Survey for the optical properties, and the Two Micron All Sky Survey for the near-infrared properties. We confirm that the parameters are indeed correlated where a single physical parameter can explain 83% of the variations. When color (g-i is included, the first component still dominates but it develops a second principal component. In addition, the near-infrared color (i-J shows an obvious second principal component that might provide evidence of the complex old star formation. Based on our data, we suggest that it is premature to pronounce the failure of the CDM model and it motivates more theoretical work.

  2. First principles analysis of hydrogen chemisorption on Pd-Re alloyed overlayers and alloyed surfaces

    Pallassana, Venkataraman; Neurock, Matthew; Hansen, Lars Bruno;


    Gradient corrected periodic density functional theory (DFT-GGA) slab calculations were used to examine the chemisorption of atomic hydrogen on various Pd-Re alloyed overlayers and uniformly alloyed surfaces. Adsorption was examined at 33% surface coverage, where atomic hydrogen preferred the three......-fold fcc sites. The binding energy of atomic hydrogen is observed to vary by as much as 0.7 eV due to Pd-Re interactions. The computed adsorption energies were found to be between -2.35 eV [for monolayer Pd-on-Re, i.e., Pd-ML/Re(0001)] and -3.05 eV [for Pd-33 Re-66/Pd(111)]. A d-band weighting scheme...... was developed to extend the Hammer-Norskov surface reactivity model [Surf. Sci. 343, 211 (1995)] to the analysis of bimetallic Pd-Re alloyed systems. The hydrogen chemisorption energies are correlated linearly to the surface d-band center, which is weighted appropriately by the d-band coupling matrix elements...

  3. Improvements in Alzheimer's disease diagnosis using principle components analysis (PCA) in combination with Raman spectroscopy

    Archer, John K. J.; Sudworth, Caroline D.; Williams, Rachel; How, Thien; Stone, Nicholas; Mann, David; Black, Richard A.


    The significant achievements of medical science over the last century are evident in the increasing age of the global population, however this now brings new problems, the most prominent being the growth in the number of people suffering from dementia. Over half the people with dementia in the UK are sufferers of Alzheimer's disease, a condition in which intraneuronal neurofibrillary tangles and extraneuronal senile tangles take over neurons prompting their death. A definitive diagnosis is still only currently available post-mortem, whilst current symptom based processes of elimination are far from perfect, especially when the only treatments available are symptom inhibiting drugs. Principal component analysis (PCA) of the Raman spectra taken from brain tissue has proved to be a potential tool in the diagnosis. However, this work now has to be refined in order to progress to tissue less associated with the symptoms of Alzheimer's disease. The first step of this has already been taken in progressing from frontal tissue to occipital tissue point spectra taken at random positions from bulk tissue. Now we present initial work into acquiring Raman spectral maps from across a tissue area, in pursuit of identifying unique plaque and tangle spectra. These spectra are presented alongside synthetic β-Amyloid spectra, in a study of the role that the peptide plays in the biomarker spectra, and how this information can aid the PCA of bulk tissue, and point towards a Raman spectroscopic test on less sensitive tissue, such as blood.

  4. Principles of Proper Validation

    Esbensen, Kim; Geladi, Paul


    Validation in chemometrics is presented using the exemplar context of multivariate calibration/prediction. A phenomenological analysis of common validation practices in data analysis and chemometrics leads to formulation of a set of generic Principles of Proper Validation (PPV), which is based...

  5. Cosmological principle

    Wesson, P.S.


    The Cosmological Principle states: the universe looks the same to all observers regardless of where they are located. To most astronomers today the Cosmological Principle means the universe looks the same to all observers because density of the galaxies is the same in all places. A new Cosmological Principle is proposed. It is called the Dimensional Cosmological Principle. It uses the properties of matter in the universe: density (rho), pressure (p), and mass (m) within some region of space of length (l). The laws of physics require incorporation of constants for gravity (G) and the speed of light (C). After combining the six parameters into dimensionless numbers, the best choices are: 8..pi..Gl/sup 2/ rho/c/sup 2/, 8..pi..Gl/sup 2/ rho/c/sup 4/, and 2 Gm/c/sup 2/l (the Schwarzchild factor). The Dimensional Cosmological Principal came about because old ideas conflicted with the rapidly-growing body of observational evidence indicating that galaxies in the universe have a clumpy rather than uniform distribution. (SC)

  6. Genetic principles.

    Abuelo, D


    The author discusses the basic principles of genetics, including the classification of genetic disorders and a consideration of the rules and mechanisms of inheritance. The most common pitfalls in clinical genetic diagnosis are described, with emphasis on the problem of the negative or misleading family history.

  7. The Application of Cooperation Principle and Politeness Principle in Oral Teaching



    The pragmatic principle that people should comply with in communicative activities are the principles of cooperation and politeness principle. The principles of cooperation play a regulatory role in communication while politeness principle actually has a greater binding. In teaching, teachers should always teach basing on language and make students understand the Cooperative Principle and Politeness Principle in pragmatics in order to improve oral communication skills.

  8. Transforming Teacher Education, An Activity Theory Analysis

    McNicholl, Jane; Blake, Allan


    This paper explores the work of teacher education in England and Scotland. It seeks to locate this work within conflicting sociocultural views of professional practice and academic work. Drawing on an activity theory framework that integrates the analysis of these seemingly contradictory discourses with a study of teacher educators' practical…

  9. Analysis of Humor in the Dialogues of The Big Bang Theory——From the Perspective of the Cooperative Principle



    <正>Part One Introduction In 1967,Herbert Paul Grice first proposed the notion of"Cooperative Principle".He claimed that both parts should stick to a series of principles in order to achieve successful communication.(He Ziran,Chen Xinren,2004).

  10. Design and analysis of switching reduced-order observer and separation principle for T-S fuzzy system

    YAN ShiYu; SUN ZengQi


    This paper designs and analyzes switching fuzzy reduced-order observer and proves that the corresponding separation principle does hold. A numerical simulation and comparison with smooth fuzzy full-order observer are given to assess switching fuzzy reduced-order observer and the validity of the separation principles.

  11. Principle component analysis and linear discriminant analysis of multi-spectral autofluorescence imaging data for differentiating basal cell carcinoma and healthy skin

    Chernomyrdin, Nikita V.; Zaytsev, Kirill I.; Lesnichaya, Anastasiya D.; Kudrin, Konstantin G.; Cherkasova, Olga P.; Kurlov, Vladimir N.; Shikunova, Irina A.; Perchik, Alexei V.; Yurchenko, Stanislav O.; Reshetov, Igor V.


    In present paper, an ability to differentiate basal cell carcinoma (BCC) and healthy skin by combining multi-spectral autofluorescence imaging, principle component analysis (PCA), and linear discriminant analysis (LDA) has been demonstrated. For this purpose, the experimental setup, which includes excitation and detection branches, has been assembled. The excitation branch utilizes a mercury arc lamp equipped with a 365-nm narrow-linewidth excitation filter, a beam homogenizer, and a mechanical chopper. The detection branch employs a set of bandpass filters with the central wavelength of spectral transparency of λ = 400, 450, 500, and 550 nm, and a digital camera. The setup has been used to study three samples of freshly excised BCC. PCA and LDA have been implemented to analyze the data of multi-spectral fluorescence imaging. Observed results of this pilot study highlight the advantages of proposed imaging technique for skin cancer diagnosis.

  12. Optimal decisions principles of programming

    Lange, Oskar


    Optimal Decisions: Principles of Programming deals with all important problems related to programming.This book provides a general interpretation of the theory of programming based on the application of the Lagrange multipliers, followed by a presentation of the marginal and linear programming as special cases of this general theory. The praxeological interpretation of the method of Lagrange multipliers is also discussed.This text covers the Koopmans' model of transportation, geometric interpretation of the programming problem, and nature of activity analysis. The solution of t

  13. First-principles analysis of the C-N bond scission of methylamine on Mo-based model catalysts

    Lv, Cun-Qin; Li, Jun; Tao, Shu-Xia; Ling, Kai-Cheng; Wang, Gui-Chang


    The C-N bond breaking of methylamine on clean, carbon (nitrogen, oxygen)-modified Mo(100) [denoted as Mo(100) and Mo(100)-C(N,O), respectively], Mo2C(100), MoN(100), and Pt(100) surfaces has been investigated by the first-principles density functional theory (DFT) calculations. The results show that the reaction barriers of the C-N bond breaking in CH3NH2 on Mo(100)-C(N,O) are higher than that on clean Mo(100). The calculated energy barrier can be correlated linearly with the density of Mo 4d states at the Fermi level after the adsorption of CH3NH2 for those surfaces. Moreover, the DFT results show that the subsurface atom, e.g., carbon, can reduce the reaction barrier. In addition, We noticed that the activation energies for the C-N bond breaking on Mo2C(100) and MoN(100) are similar to that on Pt(100), suggesting that the catalytic properties of the transition metal carbides and nitrides for C-N bond scission of CH3NH2 might be very similar to the expensive Pt-group metals.

  14. Gene Expression of Type VI Secretion System Associated with Environmental Survival in Acidovorax avenae subsp. avenae by Principle Component Analysis.

    Cui, Zhouqi; Jin, Guoqiang; Li, Bin; Kakar, Kaleem Ullah; Ojaghian, Mohammad Reza; Wang, Yangli; Xie, Guanlin; Sun, Guochang


    Valine glycine repeat G (VgrG) proteins are regarded as one of two effectors of Type VI secretion system (T6SS) which is a complex multi-component secretion system. In this study, potential biological roles of T6SS structural and VgrG genes in a rice bacterial pathogen, Acidovorax avenae subsp. avenae (Aaa) RS-1, were evaluated under seven stress conditions using principle component analysis of gene expression. The results showed that growth of the pathogen was reduced by H₂O₂ and paraquat-induced oxidative stress, high salt, low temperature, and vgrG mutation, compared to the control. However, pathogen growth was unaffected by co-culture with a rice rhizobacterium Burkholderia seminalis R456. In addition, expression of 14 T6SS structural and eight vgrG genes was significantly changed under seven conditions. Among different stress conditions, high salt, and low temperature showed a higher effect on the expression of T6SS gene compared with host infection and other environmental conditions. As a first report, this study revealed an association of T6SS gene expression of the pathogen with the host infection, gene mutation, and some common environmental stresses. The results of this research can increase understanding of the biological function of T6SS in this economically-important pathogen of rice.

  15. Gene Expression of Type VI Secretion System Associated with Environmental Survival in Acidovorax avenae subsp. avenae by Principle Component Analysis

    Zhouqi Cui


    Full Text Available Valine glycine repeat G (VgrG proteins are regarded as one of two effectors of Type VI secretion system (T6SS which is a complex multi-component secretion system. In this study, potential biological roles of T6SS structural and VgrG genes in a rice bacterial pathogen, Acidovorax avenae subsp. avenae (Aaa RS-1, were evaluated under seven stress conditions using principle component analysis of gene expression. The results showed that growth of the pathogen was reduced by H2O2 and paraquat-induced oxidative stress, high salt, low temperature, and vgrG mutation, compared to the control. However, pathogen growth was unaffected by co-culture with a rice rhizobacterium Burkholderia seminalis R456. In addition, expression of 14 T6SS structural and eight vgrG genes was significantly changed under seven conditions. Among different stress conditions, high salt, and low temperature showed a higher effect on the expression of T6SS gene compared with host infection and other environmental conditions. As a first report, this study revealed an association of T6SS gene expression of the pathogen with the host infection, gene mutation, and some common environmental stresses. The results of this research can increase understanding of the biological function of T6SS in this economically-important pathogen of rice.

  16. Screening of the key volatile organic compounds of Tuber melanosporum fermentation by aroma sensory evaluation combination with principle component analysis.

    Liu, Rui-Sang; Jin, Guang-Huai; Xiao, Deng-Rong; Li, Hong-Mei; Bai, Feng-Wu; Tang, Ya-Jie


    Aroma results from the interplay of volatile organic compounds (VOCs) and the attributes of microbial-producing aromas are significantly affected by fermentation conditions. Among the VOCs, only a few of them contribute to aroma. Thus, screening and identification of the key VOCs is critical for microbial-producing aroma. The traditional method is based on gas chromatography-olfactometry (GC-O), which is time-consuming and laborious. Considering the Tuber melanosporum fermentation system as an example, a new method to screen and identify the key VOCs by combining the aroma evaluation method with principle component analysis (PCA) was developed in this work. First, an aroma sensory evaluation method was developed to screen 34 potential favorite aroma samples from 504 fermentation samples. Second, PCA was employed to screen nine common key VOCs from these 34 samples. Third, seven key VOCs were identified by the traditional method. Finally, all of the seven key VOCs identified by the traditional method were also identified, along with four others, by the new strategy. These results indicate the reliability of the new method and demonstrate it to be a viable alternative to the traditional method.

  17. Principle Component Analysis of two-particle correlations in PbPb and pPb collisions at CMS

    Milosevic, Jovan


    A Principle Component Analysis (PCA) of two-particle azimuthal correlations as a function of transverse momentum (pT) is presented in PbPb collisions at 2.76 TeV and high-multiplicity pPb collisions at 5.02 TeV. The data were recorded using the CMS detector at the LHC. It was shown that factorization breaking of two-particle azimuthal correlations can be attributed to the effect of initial-state fluctuations. Using a PCA approach, Fourier coefficients of observed two-particle azimuthal correlations as a function of both particles' pT are characterized into leading and sub-leading mode terms. The leading modes are essentially equivalent to anisotropy harmonics (vn) previously extracted from two-particle correlation methods as a function of pT. The sub-leading modes represent the largest sources of factorization breaking. In the context of hydrodynamic models, they are a direct consequence of initial-state fluctuations. The results are presented over a wide range of centrality and event multiplicity. The results are connected to the measurement of pT-dependent flow factorization breaking.

  18. A Review of Mid-Infrared and Near-Infrared Imaging: Principles, Concepts and Applications in Plant Tissue Analysis

    Sevgi Türker-Kaya


    Full Text Available Plant cells, tissues and organs are composed of various biomolecules arranged as structurally diverse units, which represent heterogeneity at microscopic levels. Molecular knowledge about those constituents with their localization in such complexity is very crucial for both basic and applied plant sciences. In this context, infrared imaging techniques have advantages over conventional methods to investigate heterogeneous plant structures in providing quantitative and qualitative analyses with spatial distribution of the components. Thus, particularly, with the use of proper analytical approaches and sampling methods, these technologies offer significant information for the studies on plant classification, physiology, ecology, genetics, pathology and other related disciplines. This review aims to present a general perspective about near-infrared and mid-infrared imaging/microspectroscopy in plant research. It is addressed to compare potentialities of these methodologies with their advantages and limitations. With regard to the organization of the document, the first section will introduce the respective underlying principles followed by instrumentation, sampling techniques, sample preparations, measurement, and an overview of spectral pre-processing and multivariate analysis. The last section will review selected applications in the literature.

  19. A Review of Mid-Infrared and Near-Infrared Imaging: Principles, Concepts and Applications in Plant Tissue Analysis.

    Türker-Kaya, Sevgi; Huck, Christian W


    Plant cells, tissues and organs are composed of various biomolecules arranged as structurally diverse units, which represent heterogeneity at microscopic levels. Molecular knowledge about those constituents with their localization in such complexity is very crucial for both basic and applied plant sciences. In this context, infrared imaging techniques have advantages over conventional methods to investigate heterogeneous plant structures in providing quantitative and qualitative analyses with spatial distribution of the components. Thus, particularly, with the use of proper analytical approaches and sampling methods, these technologies offer significant information for the studies on plant classification, physiology, ecology, genetics, pathology and other related disciplines. This review aims to present a general perspective about near-infrared and mid-infrared imaging/microspectroscopy in plant research. It is addressed to compare potentialities of these methodologies with their advantages and limitations. With regard to the organization of the document, the first section will introduce the respective underlying principles followed by instrumentation, sampling techniques, sample preparations, measurement, and an overview of spectral pre-processing and multivariate analysis. The last section will review selected applications in the literature.

  20. Analysis of wind speed distributions: Wind distribution function derived from minimum cross entropy principles as better alternative to Weibull function

    Kantar, Yeliz Mert; Usta, Ilhan [Department of Statistics, Anadolu University, Eskisehir 26470 (Turkey)


    In this study, the minimum cross entropy (MinxEnt) principle is applied for the first time to the wind energy field. This principle allows the inclusion of previous information of a wind speed distribution and covers the maximum entropy (MaxEnt) principle, which is also discussed by Li and Li and Ramirez as special cases in their wind power study. The MinxEnt probability density function (pdf) derived from the MinxEnt principle are used to determine the diurnal, monthly, seasonal and annual wind speed distributions. A comparison between MinxEnt pdfs defined on the basis of the MinxEnt principle and the Weibull pdf on wind speed data, which are taken from different sources and measured in various regions, is conducted. The wind power densities of the considered regions obtained from Weibull and MinxEnt pdfs are also compared. The results indicate that the pdfs derived from the MinxEnt principle fit better to a variety of measured wind speed data than the conventionally applied empirical Weibull pdf. Therefore, it is shown that the MinxEnt principle can be used as an alternative method to estimate both wind distribution and wind power accurately. (author)

  1. Activity Analysis and Cost Analysis in Medical Schools.

    Koehler, John E.; Slighton, Robert L.

    There is no unique answer to the question of what an ongoing program costs in medical schools. The estimates of program costs generated by classical methods of cost accounting are unsatisfactory because such accounting cannot deal with the joint production or joint cost problem. Activity analysis models aim at calculating the impact of alternative…

  2. Activation analysis using {gamma} photons; Analyse par activation aux photons {gamma}

    Engelmann, Ch. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires


    This report summarizes all the data required for using photonuclear reactions in the field of analysis. After a brief review of the elementary properties of nuclear reactions induced by photon irradiation, the main characteristics are given of high energy (E > 20 MeV) Bremsstrahlung sources. The principle of activation analysis based on the use of photons is given. Actual examples of the analytic possibilities are described in detail, in particular in the case of the determination of very small quantities (< 10{sup -6}) of C, N, O and F. The influence of interfering nuclear reactions is discussed. (author) [French] Ce rapport se propose de resumer l'ensemble des connaissances indispensables pour l'utilisation des reactions photonucleaires a des fins analytiques. Apres quelques rappels concernant les proprietes elementaires des reactions nucleaires induites par irradiation dans les photons, les principales caracteristiques des sources de rayonnement de freinage de haute energie (E > 20 MeV)| sont donnees. Le principe de l'analyse par activation aux photons est rappele. Des exemples concrets sur les possibilites analytiques sont developpes, particulierement en ce qui concerne la determination de quantites tres faibles (< 10{sup -6}) de C, N, O et F. L'influence des reactions nucleaires parasites est discutee. (auteur)

  3. Multiscale statistical analysis of coronal solar activity

    Gamborino, Diana; Martinell, Julio J


    Multi-filter images from the solar corona are used to obtain temperature maps which are analyzed using techniques based on proper orthogonal decomposition (POD) in order to extract dynamical and structural information at various scales. Exploring active regions before and after a solar flare and comparing them with quiet regions we show that the multiscale behavior presents distinct statistical properties for each case that can be used to characterize the level of activity in a region. Information about the nature of heat transport is also be extracted from the analysis.

  4. 浅谈听力活动设计原则及影响因素%Design principle and influencing factor of listening activities

    陈适; 朱晨


    Many language teachers have been committed to the design of the listening activities, in order to make the students actively participate in teaching activities in classroom listening, and obtain satisfactory learning effect. According to the author's own teaching experience and professional literature, summarizes and expounds the factors influencing the design principle and listening activities.%很多语言教学工作者一直致力于听力活动的设计,以求能让学生积极主动地参与课堂听力教学活动,并获得较为满意的学习效果。本文结合作者的自身教学经验以及一些专业文献资料,简单归纳和阐述了听力活动设计的原则以及影响因素。




    Full Text Available The problem premises and the objectives followed: the idea of inserting the equality principle between the freedom and the justice principles is manifested in positive law in two stages, as a general idea of all judicial norms and as requirement of the owner of a subjective right of the applicants of an objective law. Equality in face of the law and of public authorities can not involve the idea of standardization, of uniformity, of enlisting of all citizens under the mark of the same judicial regime, regardless of their natural or socio-professional situation. Through the Beijing Platform and the position documents of the European Commission we have defined the integrative approach of equality as representing an active and visible integration of the gender perspective in all sectors and at all levels. The research methods used are: the conceptualist method, the logical method and the intuitive method necessary as means of reasoning in order to argue our demonstration. We have to underline the fact that the system analysis of the research methods of the judicial phenomenon doesn’t agree with “value ranking”, because one value cannot be generalized in rapport to another. At the same time, we must fight against a methodological extremism. The final purpose of this study is represented by the reaching of the perfecting/excellence stage by all individuals through the promotion of equality and freedom. This supposes the fact that the existence of a non-discrimination favourable frame (fairness represents a means and a condition of self-determination, and the state of perfection/excellency is a result of this self-determination, the condition necessary for the obtaining of this nondiscrimination frame for all of us and in conditions of freedom for all individuals, represents the same condition that promotes the state of perfection/excellency. In conclusion we may state the fact that the equality principle represents a true catalyst of the

  6. An Analysis of the Reason Why Tess Loses Virginity from Her Conver-sations with Alec in Tess of the D'Urbervilles Based on the Cooperative Principle

    ZHANG Yu-jia


    Cooperative Principle is an essential linguistic theory in Pragmatics which is used to analyze the conversation. And the violation of maxims in Cooperative Principle can imply the conversational implicatures other than what is literally said. Based on the Cooperative Principle, this paper aims to exploit the implicatures and reasons after violating related maxims in conversa-tions that happens between Tess and Alec in Tess of the D'Urbervilles, and also aims to explain why Tess fails to protect herself and Alec succeeds in inducing Tess, Finally, It can be found that individual personality also contributes to Alec’s success and Tess’s losing virginity. Besides, data collection and analysis are applied to provide deeper evidences.

  7. Principles of economics textbooks

    Madsen, Poul Thøis


    Has the financial crisis already changed US principles of economics textbooks? Rather little has changed in individual textbooks, but taken as a whole ten of the best-selling textbooks suggest rather encompassing changes of core curriculum. A critical analysis of these changes shows how individual...

  8. Modeling place field activity with hierarchical slow feature analysis

    Fabian eSchoenfeld


    Full Text Available In this paper we present six experimental studies from the literature on hippocampal place cells and replicate their main results in a computational framework based on the principle of slowness. Each of the chosen studies first allows rodents to develop stable place field activity and then examines a distinct property of the established spatial encoding, namely adaptation to cue relocation and removal; directional firing activity in the linear track and open field; and results of morphing and stretching the overall environment. To replicate these studies we employ a hierarchical Slow Feature Analysis (SFA network. SFA is an unsupervised learning algorithm extracting slowly varying information from a given stream of data, and hierarchical application of SFA allows for high dimensional input such as visual images to be processed efficiently and in a biologically plausible fashion. Training data for the network is produced in ratlab, a free basic graphics engine designed to quickly set up a wide range of 3D environments mimicking real life experimental studies, simulate a foraging rodent while recording its visual input, and training & sampling a hierarchical SFA network.

  9. The holistic analysis of gamma-ray spectra in instrumental neutron activation analysis

    Blaauw, M.


    The subject is the computerized analysis of the gamma-ray spectra in INAA. This analysis can be separated in three parts: The conversion of the spectra to information on {gamma}-ray energies and their relative intensities (spectrum reduction), the determination of the relation between the intensity of a {gamma}-ray and the amount of the corresponding element present in the sample (standardization) and the attribution of the {gamma}-ray energies to the elements, including the subsequent computation of the amounts of the elements (interpretation). A {gamma}-ray spectrum can be considered to be the linear sum of the {gamma}-ray spectra of the individual radionuclides present in the sample. Knowing the relative activities of the different radionuclides that may be produced by activation of a single element, a {gamma}-ray spectrum in INAA can also be considered to be the linear sum of the spectra of the elements. This principle has hitherto not been used in INAA to analyze the spectra by linear least squares methods, using all {gamma}-ray energies observed in the spectrum. The implementation of this `holistic` approach required that attention be paid to both spectrum reduction, standardization and interpretation. The thesis describes the methods developed for the holistic analysis of {gamma}-ray spectra in INAA, and present results of experimental comparisons between the holistic and other approaches. (orig./HP).

  10. Future daily PM10 concentrations prediction by combining regression models and feedforward backpropagation models with principle component analysis (PCA)

    Ul-Saufie, Ahmad Zia; Yahaya, Ahmad Shukri; Ramli, Nor Azam; Rosaida, Norrimi; Hamid, Hazrul Abdul


    Future PM10 concentration prediction is very important because it can help local authorities to enact preventative measures to reduce the impact of air pollution. The aims of this study are to improve prediction of Multiple Linear Regression (MLR) and Feedforward backpropagation (FFBP) by combining them with principle component analysis for predicting future (next day, next two-day and next three-day) PM10 concentration in Negeri Sembilan, Malaysia. Annual hourly observations for PM10 in Negeri Sembilan, Malaysia from January 2003 to December 2010 were selected for predicting PM10 concentration level. Eighty percent of the monitoring records were used for training and twenty percent were used for validation of the models. Three accuracy measures - Prediction Accuracy (PA), Coefficient of Determination (R2) and Index of Agreement (IA), as well as two error measures - Normalized Absolute Error (NAE) and Root Mean Square Error (RMSE) were used to evaluate the performance of the models. Results show that PCA models combined with MLR and PCA with FFBP improved MLR and FFBP models for all three days in advance of predicting PM10 concentration, with reduced errors by as much as 18.1% (PCA-MLR) and 17.68% (PCA-FFBP) for next day, 19.2% (PCA-MLR) and 22.1% (PCA-FFBP) for next two-day and 18.7% (PCA-MLR) and 22.79% (PCA-FFBP) for next three-day predictions. Including PCA improved the accuracy of the models by as much as by 12.9% (PCA-MLR) and 13.3% (PCA-FFBP) for next day, 32.3% (PCA-MLR) and 14.7% (PCA-FFBP) for next two-day and 46.1% (PCA-MLR) and 19.3% (PCA-FFBP) for next three-day predictions.

  11. Cause Resolving of Typhoon Precipitation Using Principle Component Analysis under Complex Interactive Effect of Terrain, Monsoon and Typhoon Vortex

    Huang, C. L.; Hsu, N. S.


    This study develops a novel methodology to resolve the cause of typhoon-induced precipitation using principle component analysis (PCA) and to develop a long lead-time precipitation prediction model. The discovered spatial and temporal features of rainfall are utilized to develop a state-of-the-art descriptive statistical model which can be used to predict long lead-time precipitation during typhoons. The time series of 12-hour precipitation from different types of invasive moving track of typhoons are respectively precede the signal analytical process to qualify the causes of rainfall and to quantify affected degree of each induced cause. The causes include: (1) interaction between typhoon rain band and terrain; (2) co-movement effect induced by typhoon wind field with monsoon; (3) pressure gradient; (4) wind velocity; (5) temperature environment; (6) characteristic distance between typhoon center and surface target station; (7) distance between grade 7 storm radius and surface target station; and (8) relative humidity. The results obtained from PCA can detect the hidden pattern of the eight causes in space and time and can understand the future trends and changes of precipitation. This study applies the developed methodology in Taiwan Island which is constituted by complex diverse terrain formation and height. Results show that: (1) for the typhoon moving toward the direction of 245° to 330°, Causes (1), (2) and (6) are the primary ones to generate rainfall; and (2) for the direction of 330° to 380°, Causes (1), (4) and (6) are the primary ones. Besides, the developed precipitation prediction model by using PCA with the distributed moving track approach (PCA-DMT) is 32% more accurate by that of PCA without distributed moving track approach, and the former model can effectively achieve long lead-time precipitation prediction with an average predicted error of 13% within average 48 hours of forecasted lead-time.

  12. Widely available active sites on Ni2P for electrochemical hydrogen evolution - insights from first principles calculations

    Hansen, Martin Hangaard; Stern, Lucas-Alexandre; Feng, Ligang;


    We present insights into the mechanism and the active site for hydrogen evolution on nickel phosphide (Ni2P). Ni2P was recently discovered to be a very active non-precious hydrogen evolution catalyst. Current literature attributes the activity of Ni2P to a particular site on the (0001) facet. In ...

  13. Electrical principles 3 checkbook

    Bird, J O


    Electrical Principles 3 Checkbook aims to introduce students to the basic electrical principles needed by technicians in electrical engineering, electronics, and telecommunications.The book first tackles circuit theorems, single-phase series A.C. circuits, and single-phase parallel A.C. circuits. Discussions focus on worked problems on parallel A.C. circuits, worked problems on series A.C. circuits, main points concerned with D.C. circuit analysis, worked problems on circuit theorems, and further problems on circuit theorems. The manuscript then examines three-phase systems and D.C. transients

  14. Principles of statistics

    Bulmer, M G


    There are many textbooks which describe current methods of statistical analysis, while neglecting related theory. There are equally many advanced textbooks which delve into the far reaches of statistical theory, while bypassing practical applications. But between these two approaches is an unfilled gap, in which theory and practice merge at an intermediate level. Professor M. G. Bulmer's Principles of Statistics, originally published in 1965, was created to fill that need. The new, corrected Dover edition of Principles of Statistics makes this invaluable mid-level text available once again fo

  15. Gamescape Principles

    Nobaew, Banphot; Ryberg, Thomas


    This paper proposes a new theoretical framework or visual grammar for analysing visual aspects of digital 3D games, and for understanding more deeply the notion of Visual Digital Game Literacy. The framework focuses on the development of a visual grammar by drawing on the digital literacy framewo...... as to understand how learners posses or can develop broader critical media literacies and visual digital literacies in education.......This paper proposes a new theoretical framework or visual grammar for analysing visual aspects of digital 3D games, and for understanding more deeply the notion of Visual Digital Game Literacy. The framework focuses on the development of a visual grammar by drawing on the digital literacy framework...... and interviews) collected during a game workshop where students, studying to become game designers, developed a number of games. The visual digital literacy framework we propose consists of five main major components: Gamescape Principles, Interpretation, Style, Experiences and Practices. For the purpose...

  16. Basic Principles of Chromatography

    Ismail, Baraem; Nielsen, S. Suzanne

    Chromatography has a great impact on all areas of analysis and, therefore, on the progress of science in general. Chromatography differs from other methods of separation in that a wide variety of materials, equipment, and techniques can be used. [Readers are referred to references (1-19) for general and specific information on chromatography.]. This chapter will focus on the principles of chromatography, mainly liquid chromatography (LC). Detailed principles and applications of gas chromatography (GC) will be discussed in Chap. 29. In view of its widespread use and applications, high-performance liquid chromatography (HPLC) will be discussed in a separate chapter (Chap. 28). The general principles of extraction are first described as a basis for understanding chromatography.

  17. Constitutional Principles of State Control in the Republic of Armenia

    Gabriel K. Balayan


    Full Text Available In the present article some of the provision of the RA Constitution’s basic principles of state control, which, in my opinion, should be guided by regulatory authorities during the inspection are discussed. These principles are considered by the author as the basis of the constitutionality of state control. Some of the control principles are divided by the author into positive and negative. Positive defines the principles that provide the freedom of action of man and citizen. Negative same principles are for government agencies, since they restrict their activities. A separate analysis is subject to the presidency on the basis of the principle of separation and balance of powers. In conclusion, author concludes that, based on the interpretation of the constitutional principles discussed, the term "law" applies only to natural and legal persons on the other hand can not be used as an analogue of the terms "authority" and "authority." According to the author, the fundamental constitutional principles of state control are expressed formally in a single system as defined in the first chapter of the Constitution of the Republic of Armenia. Compliance and reform of constitutional principles provide the synergy and the constitutionality of the process of governance.

  18. Collection and analysis of active particles

    DeLong, C.W.


    When it became apparent that particles were emanating from the stacks of the separations plants, it become important that the source, size, activity and composition of the particles be determined in order to evaluate the hazard to persons working in and neer the stack areas. The present report will give the results of radiochemical analysis of particles collected by electrostatic precipitation from ``B`` plant canyon ventilation air, not from the off-gas ventilation line. Of importance is the fact the particles analyzed consist not only of particles from the ventilation air but also, unavoidably, of rust from the iron manifold used to conduct the gases to the precipitator. This makes a determination of the activity versus weight ratio impossible, but should not invalidate the radiochemical data.

  19. Recommendations for sex/gender neuroimaging research: Key principles and implications for research design, analysis and interpretation

    Gina eRippon


    Full Text Available For over a decade, neuroimaging (NI technologies have had an increasing impact in the study of complex cognitive and social processes. In this emerging field of social cognitive neuroscience, a central goal should be to increase the understanding of the interaction between the neurobiology of the individual and the environment in which s/he develops and functions. The study of the relationship between sex and gender could offer a valuable example of such research. We identify here four main principles that should inform NI research. First, the principle of overlap, arising from evidence of significant overlap of female/male distributions on measures of many gendered behaviours. Second, the principle of mosaicism, arising from evidence that for both behaviour and brain, each individual manifests a complex and idiosyncratic combination of feminine and masculine characteristics. Third, the principle of contingency, arising from evidence that female/male behavioural differences are contingent on time, place, social group and context. Fourth, the principle of entanglement, arising from an awareness that the neural phenotypes that NI techniques measure are a function of the interactive and reciprocal influence of biology and environment. These important principles have emerged and become well-established over the past few decades, but their implications are often not reflected in the design and interpretation of NI sex/gender research. We therefore offer a set of guidelines for researchers to ensure that NI sex/gender research is appropriately designed and interpreted. We hope this ‘toolkit’ will also be of use to editorial boards and journal reviewers, as well as those who view, communicate and interpret such research.

  20. Structural Principle Analysis of SBC Braking System on BENZ%奔驰轿车SBC制动系统的结构原理分析



    SBC which stands for sensotronic brake control is an electrically activated braking system equipped on BENZ. The author introduces its composition, analyzes its working principle and advantages.%SBC是奔驰轿车采用的一种电子感应制动系统,介绍SBC的结构组成,分析该系统的工作原理和优点。

  1. An Analysis of Factors that Inhibit Business Use of User-Centered Design Principles: A Delphi Study

    Hilton, Tod M.


    The use of user-centered design (UCD) principles has a positive impact on the use of web-based interactive systems in customer-centric organizations. User-centered design methodologies are not widely adopted in organizations due to intraorganizational factors. A qualitative study using a modified Delphi technique was used to identify the factors…

  2. Ultrasonic Weve Cleaning Principle and Process Analysis%超声波清洗原理与工艺分析

    孙洪日; 林国辉


    论述了超声波清洗的原理及其在电子制造业中应用。并对实际生产作业中出现的问题给予分析。%Expound ultrasonic wave cleaning principle and the ap plicationto electronic manufacture industry.Analyse the questions during actral production.

  3. Calculation of Raman optical activity spectra for vibrational analysis.

    Mutter, Shaun T; Zielinski, François; Popelier, Paul L A; Blanch, Ewan W


    By looking back on the history of Raman Optical Activity (ROA), the present article shows that the success of this analytical technique was for a long time hindered, paradoxically, by the deep level of detail and wealth of structural information it can provide. Basic principles of the underlying theory are discussed, to illustrate the technique's sensitivity due to its physical origins in the delicate response of molecular vibrations to electromagnetic properties. Following a short review of significant advances in the application of ROA by UK researchers, we dedicate two extensive sections to the technical and theoretical difficulties that were overcome to eventually provide predictive power to computational simulations in terms of ROA spectral calculation. In the last sections, we focus on a new modelling strategy that has been successful in coping with the dramatic impact of solvent effects on ROA analyses. This work emphasises the role of complementarity between experiment and theory for analysing the conformations and dynamics of biomolecules, so providing new perspectives for methodological improvements and molecular modelling development. For the latter, an example of a next-generation force-field for more accurate simulations and analysis of molecular behaviour is presented. By improving the accuracy of computational modelling, the analytical capabilities of ROA spectroscopy will be further developed so generating new insights into the complex behaviour of molecules.

  4. Principle and Control Design of Active Ground-Fault Arc Suppression Device for Full Compensation of Ground Current

    Wang, Wen; Zeng, Xiangjun; Yan, Lingjie;


    Traditional ground-fault arc suppression devices mainly deal with capacitive component of ground current and have weak effect on the active and harmonic ones, which limits the arc suppression performance. The capacitive current detection needed in them suffers from low accuracy and robustness....... The commonly-used large-capacity reactive component may bring about overvoltage because of possible resonance with the distributed phase-to-ground capacitance. To solve these problems, an active ground-fault arc suppression device is presented. It employs a topology based on single-phase inverter to inject...... current into the neutral without any large-capacity reactors, and thus avoids the aforementioned overvoltage. It compensates all the active, reactive and harmonic components of the ground current to reliably extinguish the ground-fault arcs. A dual-loop voltage control method is proposed to realize arc...

  5. Novel Principles of Gamma-Retroviral Insertional Transcription Activation in Murine Leukemia Virus-induced End-stage Tumors

    Sokol, Martin; Wabl, Matthias; Rius Ruiz, Irene;


    Background Insertional mutagenesis screens of retrovirus-induced mouse tumors have proven valuable in human cancer research and for understanding adverse effects of retroviral-based gene therapies. In previous studies, the assignment of mouse genes to individual retroviral integration sites has...... been based on close proximity and expression patterns of annotated genes at target positions in the genome. We here employed next-generation RNA sequencing to map retroviral-mouse chimeric junctions genome-wide, and to identify local patterns of transcription activation in T-lymphomas induced...... than 2,000 mice was examined. Results We detected several novel mechanisms of retroviral insertional mutagenesis: bidirectional activation of mouse transcripts on opposite sides of a provirus including transcription of unannotated mouse sequence; sense/antisense-type activation of genes located...

  6. Effect of rTMS on brain activation in schizophrenia with negative symptoms : A proof-of-principle study

    Dlabac-de Lange, Jozarni J.; Liemburg, Edith J.; Bais, Leonie; Renken, Remco J.; Knegtering, Henderikus; Aleman, Andre


    Background: Prefrontal cortical dysfunction is frequently reported in schizophrenia and is thought to underlie negative symptoms of schizophrenia. Repetitive Transcranial Magnetic Stimulation (rTMS) can modulate neuronal activity and has been shown to improve negative symptoms in patients with schiz

  7. Fundamental principles, measurement techniques and data analysis in a ion accelerator; Principios fundamentales, tecnicas de medicion y analisis de datos en un acelerador de iones

    Gonzalez M, O. [Facultad de Ciencias, UNAM, Ciudad Universitaria, 04510 Mexico D. F. (Mexico); Gleason, C. [Facultad de Ciencias, Universidad Autonoma del Estado de Morelos, Cuernavaca, Morelos (Mexico); Hinojosa, G. [Instituto de Ciencias Fisicas, UNAM, Ciudad Universitaria, 04510 Mexico D. F. (Mexico)]. e-mail:


    The present work is intended to be a general reference for students and professionals interested in the field. Here, we present an introduction to the analysis techniques and fundamental principles for data processing and operation of a typical ion accelerator that operates in the low energy range. We also present a detailed description of the apparatus and propose new analysis methods for the results. In addition, we introduce illustrative simulations of the ion's trajectories in the different components of the apparatus performed with specialized software and, a new computer data acquisition and control interface. (Author)

  8. Effect of the Principle of Activating Blood Circulation to Break Stasis on GMP-140 and D2 Dimer in Patients with Acute Cerebral Infarction

    WANG Ning


    Objective:To explore the clinical efficacy of the principle of activating blood circulation to break stasis (ABCBS) and its influence on platelet membranous protein particle (GMP-140) and D2 dimer (Ddimer) before and after treatment. Methods: Eighty-eight patients with blood stasis syndrome (BSS) of acute cerebral infarction (ACI) were randomly divided into two groups, both of which were treated with conventional treatment, i.e. with western medicine (WM), with Salvia injection added through intravenously dripping.One of the two groups was used as the control and the other group as the treated group who had ABCBS herbs orally taken in addition. The duration of treatment course for both groups was 3 weeks. Results: There were changes in both groups over clinical symptoms, nerve function deficit scoring and GMP-140, D-dimer, but the treated group showed significantly better than that of the control group, (P<0.05). Conclusion: ABCBS principle could serve as an important auxiliary treating method for BSS of ACI, as it can effectively alter the blood of ACI patients which was viscous, condense, coagulant and aggregating.

  9. A correspondence principle

    Hughes, Barry D.; Ninham, Barry W.


    A single mathematical theme underpins disparate physical phenomena in classical, quantum and statistical mechanical contexts. This mathematical "correspondence principle", a kind of wave-particle duality with glorious realizations in classical and modern mathematical analysis, embodies fundamental geometrical and physical order, and yet in some sense sits on the edge of chaos. Illustrative cases discussed are drawn from classical and anomalous diffusion, quantum mechanics of single particles and ideal gases, quasicrystals and Casimir forces.

  10. Content Analysis in Systems Engineering Acquisition Activities


    qÜáêíÉÉåíÜ=^ååì~ä= ^Åèìáëáíáçå=oÉëÉ~êÅÜ= póãéçëáìã= tÉÇåÉëÇ~ó=pÉëëáçåë= sçäìãÉ=f= = Content Analysis in Systems Engineering Acquisition Activities Karen...Ü~åÖÉ= - 47 - Panel 3. Systems Engineering : New Thinking for a New Age Wednesday, May 4, 2016 11:15 a.m. – 12:45 p.m. Chair: John D. Burrow...Deputy Assistant Secretary of the Navy for Research, Development, Test, & Evaluation (DASN RDT&E) Rethinking the Systems Engineering Process in Light

  11. Chemical-state analysis of organic semiconductors using soft X-ray absorption spectroscopy combined with first-principles calculation.

    Natsume, Yutaka; Kohno, Teiichiro; Minakata, Takashi; Konishi, Tokuzo; Gullikson, Eric M; Muramatsu, Yasuji


    The chemical states of organic semiconductors were investigated by total-electron-yield soft X-ray absorption spectroscopy (TEY-XAS) and first-principles calculations. The organic semiconductors, pentacene (C(22)H(14)) and pentacenequinone (C(22)H(12)O(2)), were subjected to TEY-XAS and the experimental spectra obtained were compared with the 1s core-level excited spectra of C and O atoms, calculated by a first-principles planewave pseudopotential method. Excellent agreement between the measured and the calculated spectra were obtained for both materials. Using this methodology, we examined the chemical states of the aged pentacene, and confirmed that both C-OH and C═O chemical bonds are generated by exposure to air. This result implies that not only oxygen but also humidity causes pentacene oxidation.

  12. Principles of sound ecotoxicology.

    Harris, Catherine A; Scott, Alexander P; Johnson, Andrew C; Panter, Grace H; Sheahan, Dave; Roberts, Mike; Sumpter, John P


    We have become progressively more concerned about the quality of some published ecotoxicology research. Others have also expressed concern. It is not uncommon for basic, but extremely important, factors to apparently be ignored. For example, exposure concentrations in laboratory experiments are sometimes not measured, and hence there is no evidence that the test organisms were actually exposed to the test substance, let alone at the stated concentrations. To try to improve the quality of ecotoxicology research, we suggest 12 basic principles that should be considered, not at the point of publication of the results, but during the experimental design. These principles range from carefully considering essential aspects of experimental design through to accurately defining the exposure, as well as unbiased analysis and reporting of the results. Although not all principles will apply to all studies, we offer these principles in the hope that they will improve the quality of the science that is available to regulators. Science is an evidence-based discipline and it is important that we and the regulators can trust the evidence presented to us. Significant resources often have to be devoted to refuting the results of poor research when those resources could be utilized more effectively.

  13. Activity origin and catalyst design principles for electrocatalytic hydrogen evolution on heteroatom-doped graphene

    Jiao, Yan; Zheng, Yao; Davey, Kenneth; Qiao, Shi-Zhang


    The hydrogen evolution reaction (HER) is a fundamental process in electrocatalysis and plays an important role in energy conversion through water splitting to produce hydrogen. Effective candidates for HER are often based on noble metals or transition metal dichalcogenides, while carbon-based metal-free electrocatalysts generally demonstrate poorer activity. Here we report evaluation of a series of heteroatom-doped graphene materials as efficient HER electrocatalysts by combining spectroscopic characterization, electrochemical measurements, and density functional theory calculations. Results of theoretical computations are shown to be in good agreement with experimental observations regarding the intrinsic electrocatalytic activity and the HER reaction mechanism. As a result, we establish a HER activity trend for graphene-based materials, and explore their reactivity origin to guide the design of more efficient electrocatalysts. We predict that by rationally modifying particular experimentally achievable physicochemical characteristics, a practically realizable graphene-based material will have the potential to exceed the performance of the metal-based benchmark for HER.

  14. First principles investigation of the activity of thin film Pt, Pd and Au surface alloys for oxygen reduction

    Tripkovic, Vladimir; Hansen, Heine Anton; Rossmeisl, Jan;


    active binary thin films are near-surface alloys of Pt with subsurface Pd and certain PdAu and PtAu thin films with surface and/or subsurface Au. The most active ternary thin films are with pure metal Pt or Pd skins with some degree of Au in the surface and/or subsurface layer and the near-surface alloys...... of Au with mixed Pt/Pd skins. The activity of the binary and ternary catalysts is explained through weakening of the OH binding energy caused by solute elements. However, given the low alloy formation energies it may be difficult to tune and retain the composition under operating conditions....... This is particularly challenging for alloys containing Au due to a high propensity of Au to segregate to the surface. We also show that once Au is on the surface it will diffuse to defect sites, explaining why small amounts of Au retard dissolution of Pt nanoparticles. For the PtPd thin films there is no pronounced...

  15. Using Human Panels for Subjective Evaluation of Emissions from Indoor Activities and Materials: Principles and State of Technology

    Cometto-Muñiz, J E


    This report addresses the topic of sensory evaluation of indoor air through the use of human subjects. It begins by discussing the chemical senses involved in such evaluation, specifically the senses of smell (olfaction) and chemical sensory irritation (common chemical sense, CCS, now called chemesthesis). An analysis of similarities and differences between these two sensory modalities regarding key measurements and issues follows. Later, the report discusses the quantification of sensory rea...

  16. Analysis of physical activities in Taekwondo Pumsae.

    Lee, Sang-Bock; Cha, Eun-Jong; Lee, Tae-Soo


    Exercise is very important element for successful aging. Among many sports events, Korea is the suzerain of Taekwondo. When competing (Taekwondo Free Fighting) after learning Poomse as basic movements and inuring them, people compete with movements depending on situation. Among Poomses of Taekwondo, Taegeuk Poomse consists of very basic movements from 1 Jang to 8 Jang and they are for inuring to body. In order to prescribe Taegeuk Jang, which is the basic movement of Taekwondo that Korea is the suzerain, as an exercise for successful aging, it is necessary to analyze physical activity level of each Taegeuk Jang (From 1 Jang through 8 Jang) and suggest the same. Therefore, in this study, I analyzed physical activity level of each Jang of Taegeuk Poomse by attaching Armband made by Body Media Company on brachia and legs below knee of Taekwondo trainees. The result of the analysis of the whole momentum from Taegeuk 1 Jang to 8 Jang is as follows: First, the average absolute value of acceleration variation of vertical direction signal (L-MAD): 5.15. Second, the average absolute value of acceleration variation of horizontal direction signal (T-MAD): 3.44. Finally, the average of calorie consumption per minute (AEE/Min): 5.06 Cal. The obtained result corresponds to proper exercise condition for successful aging and it can be utilized as data for exercise prescription for the young and the old.

  17. Cognitive tasks in information analysis: Use of event dwell time to characterize component activities

    Sanquist, Thomas F.; Greitzer, Frank L.; Slavich, Antoinette L.; Littlefield, Rik J.; Littlefield, Janis S.; Cowley, Paula J.


    Technology-based enhancement of information analysis requires a detailed understanding of the cognitive tasks involved in the process. The information search and report production tasks of the information analysis process were investigated through evaluation of time-stamped workstation data gathered with custom software. Model tasks simulated the search and production activities, and a sample of actual analyst data were also evaluated. Task event durations were calculated on the basis of millisecond-level time stamps, and distributions were plotted for analysis. The data indicate that task event time shows a cyclic pattern of variation, with shorter event durations (< 2 sec) reflecting information search and filtering, and longer event durations (> 10 sec) reflecting information evaluation. Application of cognitive principles to the interpretation of task event time data provides a basis for developing “cognitive signatures” of complex activities, and can facilitate the development of technology aids for information intensive tasks.

  18. 论批评性话语分析的原则和方法%The Analysis of Principles and Methods of Critical Discourse Analysis



    Critical discourse analysis,whose theoretical base is Marxism,has a history of thirty years and aims at reveal unbalanced power relationship.Critical discourse analysis mainly has three ways,which are systemic functional grammar analysis,genre analysis of the interleaver and historical background discourse analysis.These three methods focus on different aspects and complement one another.They enable critical discourse analysis to be the important complement of traditionally social and cultural analysis as well as a kind of social activity,which boosts the progress of human society.%批评性话语分析已有30年的发展历史,其基本理论渊源是西方马克思主义,宗旨是揭露不平等的权力关系。其主要方法有:系统功能语法分析、语篇体裁交织性分析和话语历史背景分析。这三种方法各有侧重,互为补充。它们使批评性话语分析成为传统的社会和文化分析的重要补充,使其变为一种社会行动,促进人类社会的进步。

  19. First principles investigation of the activity of thin film Pt, Pd and Au surface alloys for oxygen reduction

    Tripkovic, Vladimir; Hansen, Heine Anton; Rossmeisl, Jan


    Further advances in fuel cell technologies are hampered by kinetic limitations associated with the sluggish cathodic oxygen reduction reaction. We have investigated a range of different formulations of binary and ternary Pt, Pd and Au thin films as electrocatalysts for oxygen reduction. The most...... active binary thin films are near-surface alloys of Pt with subsurface Pd and certain PdAu and PtAu thin films with surface and/or subsurface Au. The most active ternary thin films are with pure metal Pt or Pd skins with some degree of Au in the surface and/or subsurface layer and the near-surface alloys....... This is particularly challenging for alloys containing Au due to a high propensity of Au to segregate to the surface. We also show that once Au is on the surface it will diffuse to defect sites, explaining why small amounts of Au retard dissolution of Pt nanoparticles. For the PtPd thin films there is no pronounced...

  20. Included or Excluded: An Analysis of the Application of the Free, Prior and Informed Consent Principle in Land Grabbing Cases in Cameroon

    Jean-Claude N Ashukem


    Full Text Available Even though the principle of free, prior and informed consent (FPIC is soft law, the need to respect, protect and fulfil the rights to be informed and to be involved in development projects is strongly backed in international legal instruments including inter alia the ILO Convention 169 Concerning Indigenous and Tribal People in Independent Countries (1998 and the UN Declaration on the Rights of Indigenous and Tribal People (2007. These instruments do not only appear to be the most comprehensive and advanced international legal instruments that deal with indigenous peoples' rights in terms of the FPIC, but also signal an addition to the growing body of international human rights law that serves to ensure the realisation and protection of the substantive environmental and other human rights of indigenous people, particularly in the context of land grabbing activities that have the potential to negatively impact on their rights. Such rights include, for example, the rights to be informed and to participate in decision-making processes with respect to development projects, including land grabbing activities. This implies an obligation on states party to such international agreements to ensure that indigenous people are informed about and are actively involved in both the negotiation and the implementation of land grabbing deals. However, because the latter often takes place against the background of non-transparent transactions which are inimical to the rights and interests of indigenous people, one may wonder why the principle of FPIC is not applicable during land grabbing transactions. Focusing on Cameroon, this article examines instances of land grabbing in the country in order to support this hypothesis. This is done by focusing specifically on the application of the principle of FPIC. The arguments in the article are inspired by international law in which the application of the principle in the context of land grabbing serves not only to

  1. Diabetes melito: plantas e princípios ativos naturais hipoglicemiantes Diabetes mellitus: hypoglicemic plants and natural active principles

    Giuseppina Negri


    Full Text Available O diabetes melito é considerada como uma síndrome que é, quanto a etiologia e patogênese, caracterizada por alterar a homeostase do organismo, por distúrbios metabólicos complexos e primários dos carboidratos, que envolvem secundariamente, porém de forma importante, lipídeos e proteínas. Grande número de espécies de plantas tem sido usado experimentalmente para tratar os sintomas do diabetes melito e a distância filogenética entre este grupo de plantas é forte indicação da natureza variada de seus constituintes. Tem sido constatado que muitas substâncias extraídas de plantas reduzem o nível de glicose no sangue. A grande diversidade de classes químicas indica que uma variedade de mecanismos de ação deve estar envolvida na redução do nível de glicose no sangue. Algumas destas substâncias podem ter potencial terapêutico enquanto outras podem produzir hipoglicemia como um efeito colateral devido à sua toxicidade, especialmente hepatotoxidade. Este artigo apresenta uma revisão atualizada e acrescenta mais plantas e princípios ativos hipoglicemiantes à extensa lista existente nos artigos de revisão anteriores.Diabetes mellitus comprises a group of ethiologically and clinically heterogeneous disorders with a common set of symptoms: excessive thirst and hunger, muscular weakness, weight loss, excessive urination and elevation of the blood glucose level among others. There has been a striking emergence of non-insulin-dependent diabetes mellitus as a major health problem in populations undergoing modernization of life-style, both in developed and underdeveloped nations. Many species of plants have been used ethnopharmacologically or experimentally to treat symptons of diabetes mellitus. The high percentage of active plants probably reflects, at least in part, the great variety of possible active constituents and mechanisms of action. The wide diversity of chemical classes indicate a variety of mechanisms must be involved

  2. First-principles investigation of Cu-doped ZnS with enhanced photocatalytic hydrogen production activity

    Dong, Ming; Zhou, Peng; Jiang, Chuanjia; Cheng, Bei; Yu, Jiaguo


    The band structure and electronic properties of Cu-doped wurtzite ZnS were investigated by density functional theory calculations. According to the formation energies, the substitutional Cu and S vacancy defects are stable among the examined doping species. Particularly, the hybridization of substitutional Cu 3d and S 3p orbitals narrows the band gap of substitutional Cu-doped ZnS (CuZn-ZnS), while the high effective mass ratio of photogenerated holes and electrons (mh∗/me∗) in the CuZn-ZnS is beneficial for the separation and migration of the photogenerated charge carriers. Lab-synthesized CuZn-ZnS sample exhibited enhanced visible-light absorption and photocatalytic hydrogen production activity compared to pure ZnS.

  3. Operating cost analysis of anaesthesia: Activity based costing (ABC analysis

    Majstorović Branislava M.


    Full Text Available Introduction. Cost of anaesthesiology represent defined measures to determine a precise profile of expenditure estimation of surgical treatment, which is important regarding planning of healthcare activities, prices and budget. Objective. In order to determine the actual value of anaestesiological services, we started with the analysis of activity based costing (ABC analysis. Methods. Retrospectively, in 2005 and 2006, we estimated the direct costs of anestesiological services (salaries, drugs, supplying materials and other: analyses and equipment. of the Institute of Anaesthesia and Resuscitation of the Clinical Centre of Serbia. The group included all anesthetized patients of both sexes and all ages. We compared direct costs with direct expenditure, “each cost object (service or unit” of the Republican Health-care Insurance. The Summary data of the Departments of Anaesthesia documented in the database of the Clinical Centre of Serbia. Numerical data were utilized and the numerical data were estimated and analyzed by computer programs Microsoft Office Excel 2003 and SPSS for Windows. We compared using the linear model of direct costs and unit costs of anaesthesiological services from the Costs List of the Republican Health-care Insurance. Results. Direct costs showed 40% of costs were spent on salaries, (32% on drugs and supplies, and 28% on other costs, such as analyses and equipment. The correlation of the direct costs of anaestesiological services showed a linear correlation with the unit costs of the Republican Healthcare Insurance. Conclusion. During surgery, costs of anaesthesia would increase by 10% the surgical treatment cost of patients. Regarding the actual costs of drugs and supplies, we do not see any possibility of costs reduction. Fixed elements of direct costs provide the possibility of rationalization of resources in anaesthesia.

  4. Precautionary principle in international law.

    Saladin, C


    The deregulatory nature of trade rules frequently brings them into conflict with the precautionary principle. These rules dominate debate over the content and legal status of the precautionary principle at the international level. The World Trade Organization (WTO), because of its power in settling disputes, is a key player. Many States are concerned to define the precautionary principle consistent with WTO rules, which generally means defining it as simply a component of risk analysis. At the same time, many States, especially environmental and public health policymakers, see the principle as the legal basis for preserving domestic and public health measures in the face of deregulatory pressures from the WTO. The precautionary principle has begun to acquire greater content and to move into the operative articles of legally binding international agreements. It is important to continue this trend.

  5. From Principle to Action. An Analysis of the Financial Sector's Approach to Addressing Climate Change

    Mudde, P.; Abadie, A. [Sustainable Finance, Shrewsbury, Shropshire (United Kingdom)


    The Ministry of the Housing, Spatial Planning and the Environment of the Netherlands (VROM), has taken the initiative to commission a study to determine best practice approaches within the financial sector regarding climate change. This study focuses on the indirect climate change footprint of the financial sector, i.e. the impact of the financial sector's clients on climate change. The study sets out to further the body of knowledge relating to the financial sector's approach to understanding and managing the effects of climate change on their clients' business. Specifically, it offers recommendations and potential next steps for both the financial sector and the Dutch government to enable a more focused and definitive approach to understanding, addressing and incorporating climate change considerations into decision-making procedures and policy development. The paper comprises the following analysis: Chapter 1 is an introduction describing why climate change is relevant to the financial sector, and introduces 18 financial institutions which were selected as the basis for the study. Chapter 2 elaborates on challenges for the financial sector regarding the incorporation of climate change considerations into enhanced risk analysis and decision making. Chapter 3 provides a comprehensive overview of the main international business initiatives regarding climate change and sustainability. It can be seen as a summary of Annex I to this report, which identifies which initiatives the 18 financial institutions are involved in. Chapter 4 highlights selected best practices amongst the 18 financial institutions assessed. Chapter 5 provides the main conclusions of the study and puts forward general and specific recommendations and potential next steps for the Dutch government and the financial sector. The Annexes contain fact sheets containing information about the climate change strategy and main activities of these organisations.

  6. Equivalence principles and electromagnetism

    Ni, W.-T.


    The implications of the weak equivalence principles are investigated in detail for electromagnetic systems in a general framework. In particular, it is shown that the universality of free-fall trajectories (Galileo weak equivalence principle) does not imply the validity of the Einstein equivalence principle. However, the Galileo principle plus the universality of free-fall rotation states does imply the Einstein principle.

  7. 血透机超滤原理分析%Analysis of ultrafiltration principle of hemodialysis machine

    李朝伟; 王振洲; 贺建林


    This article introduced the major function and the basic concept of ultrafiltration of hemodialysis machine.Meanwhile, the realization of ultrafiltratioin was conducted through etaborating the working principle of Gambro- hemodialysis machine's ultrafiltration unit and B/BRAUN-hemodialysis machine's balance chamber and ultrafiltration pump.%介绍血透机的主要功能及超滤的基本概念,以金宝血透机超滤单元和贝朗血透机平衡腔及超滤泵系统的工作原理分析血透机超滤脱水的实现方法.

  8. High pressure liquid chromatographic analysis of the main pungent principles of solar dried West Indian ginger (Zingiber officinale Roscoe)

    Balladin, D.A.; Headley, O. [University of the West Indies, Cave Hill Campus, St. Michael, Barbados (West Indies). Centre for Resource Management and Environmental Studies; Chang-Yen, I. [University of the West Indies, St. Augustine Campus, Trinidad (West Indies). Faculty of Agriculture and Natural Sciences; McGaw, D.R. [University of the West Indies, St. Augustine Campus, Trinidad (West Indies). Dept. of Chemical Engineering


    The main pungent principles of West Indian ginger (Zingiber officinale Roscoe) were quantified and qualified using High Pressure Liquid Chromatography. This procedure was used to evaluate the pungency profile of fresh, solar dried and solar dried/steam distilled ginger rhizomes. In this investigation, the total oleoresin extracted was in the ratio [20: 1: 2] for [fresh ginger: solar dried: solar dried/steam distilled ginger rhizomes] with respect to the [6]-gingerol content. This simple isocratic HPLC method can be used to investigate the pungency profile of the extracted oleoresin from the ginger rhizomes. (author)

  9. Physical Principles for Scalable Neural Recording

    Adam Henry Marblestone*


    Full Text Available Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond resolution is a challenge beyond the limits of existing techniques in neuroscience. Entirely new approaches may be required, motivating an analysis of the fundamental physical constraints on the problem. We outline the physical principles governing brain activity mapping using optical, electrical,magnetic resonance, and molecular modalities of neural recording. Focusing on the mouse brain, we analyze the scalability of each method, concentrating on the limitations imposed by spatiotemporal resolution, energy dissipation, and volume displacement. We also study the physics of powering and communicating with microscale devices embedded in brain tissue.

  10. Principles of mathematical modeling

    Dym, Clive


    Science and engineering students depend heavily on concepts of mathematical modeling. In an age where almost everything is done on a computer, author Clive Dym believes that students need to understand and "own" the underlying mathematics that computers are doing on their behalf. His goal for Principles of Mathematical Modeling, Second Edition, is to engage the student reader in developing a foundational understanding of the subject that will serve them well into their careers. The first half of the book begins with a clearly defined set of modeling principles, and then introduces a set of foundational tools including dimensional analysis, scaling techniques, and approximation and validation techniques. The second half demonstrates the latest applications for these tools to a broad variety of subjects, including exponential growth and decay in fields ranging from biology to economics, traffic flow, free and forced vibration of mechanical and other systems, and optimization problems in biology, structures, an...

  11. Progress in neutron activation analysis for uranium

    杜鸿善; 李贵群; 董桂芝; 李俊兰; K.H.Chiu; C.M.Wai


    A new type of extractant, sym-dibenzo-16-crown-5-oxyhydroxamic acid (HL) is introduced. The extractions of UO22+, Na+, K+, Sr2+, Ba2+ and Br- were studied with HL in chloroform. The results obtained show that UO22+ can be quantitatively extracted at pH values above 5, whereas the extractions of K+, Na+, Sr2+, Ba2+ and Br- are negligible in the pH range of 2 - 7. The dependence of the distribution ratio of U(VI) on both the concentration of the HL and pH are linear, and they have the same slope of 2. This suggests that U(VI) appears to form a 1:2 complex with ligand. Uranium(VI) can be selectively separated and concentrated from interfering elements such as Na, K, Sr and Br by solvent extraction with HL under specific conditions. The recovery of uranium is nearly 100% and the radionudear purity of uranium is greater than 99.99%. Therefore, neutron activation analysis has greatly improved the sensitivity and accuracy for the detection of trace uranium from seawater.

  12. Numerical investigation and analysis of heat transfer enhancement in channel by longitudinal vortex based on field synergy principle

    Wenquan TAO; Junmei WU


    3-D numerical simulations were presented for laminar flow and heat transfer characteristics in a rectangular channel with vortex generators. The effects of Reynolds number (from 800 to 3 000), the attack angle of vortex generator (from 15° to 90°) and the shape of vortex generator were examined. The numerical results were analyzed based on the field synergy principle. It is found that the inherent mechanism of the heat transfer enhancement by longitudinal vortex can be explained by the field synergy principle, that is, the second flow generated by vortex generators results in the reduction of the intersection angle between the velocity and fluid temperature gradient. The longitudinal vortex improves the field synergy of the large downstream region of longitudinal vortex generator (LVG) and the region near (LVG); however, transverse vortex only improves the syn-ergy of the region near vortex generator. Thus, longitudinal vortex can enhance the integral heat transfer of the flow field, while transverse vortex can only enhance the local heat transfer. The synergy angle decreases with the increase of Reynolds number for the channel with LVG to differ from the result obtained from the plain channel, and the triangle winglet performs better than the rectanglar one under the same surface area condition.

  13. Liquid chromatographic analysis of the main pungent principles of solar dried West Indian ginger (Zingiber officinale Roscoe)

    Balladin, D.A.; Headley, Oliver [University of the West Indies, Center for Resource Management and Environmental Studies, St. Michael (Barbados)


    The main pungent principles and essential oils of West Indian ginger (Zingiber officinale Roscoe) were identified and quantified by liquid chromatography. The stationary phase used was (5.0 g silica gel 70-230 mesh) and the mobile phase [petroleum ether (60-80degC) : diethyl ether (3:7 v/v)]. The first 15 ml contained the very volatile and least polar compounds present in the extracted oleoresin from the solar dried ginger rhizome. These compounds are the essential oils (R{sub f} = 0.90) and 25.63% (w/w) of the total oleoresin charge to the column. The next 5 ml aliquot was without any compounds. The following 25 ml contained the shogaol fraction (R{sub f} = 0.42) and 47.74% (w/w) of the total oleoresin charge to the column. The next 5 ml aliquot was without any compounds. The following 35 ml contained the gingerol fraction (R{sub f} = 0.20) and 27.13% (w/w) of the total oleoresin charge to the column. This simple liquid chromatography method can be used to investigate the essential oils and pungent principles of the extracted oleoresin from the solar dried ginger rhizomes. (Author)

  14. Analysis of the Velocity Distribution in Partially-Filled Circular Pipe Employing the Principle of Maximum Entropy.

    Jiang, Yulin; Li, Bin; Chen, Jie


    The flow velocity distribution in partially-filled circular pipe was investigated in this paper. The velocity profile is different from full-filled pipe flow, since the flow is driven by gravity, not by pressure. The research findings show that the position of maximum flow is below the water surface, and varies with the water depth. In the region of near tube wall, the fluid velocity is mainly influenced by the friction of the wall and the pipe bottom slope, and the variation of velocity is similar to full-filled pipe. But near the free water surface, the velocity distribution is mainly affected by the contractive tube wall and the secondary flow, and the variation of the velocity is relatively small. Literature retrieval results show relatively less research has been shown on the practical expression to describe the velocity distribution of partially-filled circular pipe. An expression of two-dimensional (2D) velocity distribution in partially-filled circular pipe flow was derived based on the principle of maximum entropy (POME). Different entropies were compared according to fluid knowledge, and non-extensive entropy was chosen. A new cumulative distribution function (CDF) of partially-filled circular pipe velocity in terms of flow depth was hypothesized. Combined with the CDF hypothesis, the 2D velocity distribution was derived, and the position of maximum velocity distribution was analyzed. The experimental results show that the estimated velocity values based on the principle of maximum Tsallis wavelet entropy are in good agreement with measured values.

  15. Linear thermodynamic analysis of the reversible Selkov model: An interpretation of the Chatelier-like principle for local concentration fluctuations near thermodynamic equilibrium

    Dutt, Arun K.


    Thermodynamic analysis of the reversible Selkov model (a simple kinetic model describing glycolytic oscillations) has been done by an entropy production technique of Prigogine and it is shown that only the autocatalytic step can destabilize the steady state in this model. It is derived that at thermodynamic equilibrium, the product δS δP is always a positive quantity which appears to be a Chatelier-like principle for local concentration fluctuation applicable to the autocatalytic step S ⇄ P of this model.

  16. Principle and Fault Analysis of Voltage Regulator Circuit%电压调节器电路原理及故障分析



    Firstly, the paper explores the essential characteristics of voltage regulator through experiments, and then analyzes the circuit principle of the voltage regulator. The paper finally discusses the fault analysis method of voltage regulator circuit through the cases.%本文首先通过实验探究电压调节器的本质特性,然后分析电压调节器电路原理,最后通过案例探究电压调节器电路的故障分析方法.



    the source.  Compared with the HHC and IBC concept, the smart rotor is promising in reducing energy consumption and simplifying the control system[3]. However, in order to satisfy the requirements of vibratory load control, the flaps have to be controlled both quickly and precisely (frequency response up to 4ω, amplitude of pitch angle between 6° to 8°[4,5]. Currently, many experimental studies are being taken to develop ATEF systems using integrated actuator technology in smart structure, and to satisfy both the compact and high efficiency requirements.   The integrated actuators are made of functional materials, producing displacement under external voltage. Electrostrictive material is a kind of ferroelectric ceramic, the strain is approximately of the 2nd order relationship with actuating electric field, and can be used in the development of a solid actuator in smart rotor systems. However, since the displacement of the actuator not only depends on its structure, but also relies on external force and voltage, a mathematical model is needed to predict its output characteristics in design.  In this paper, a dynamic model of the stack actuator is derived using the principle of force equivalence, which is based on the constitutive equation of ferroelectric material and the equation of motion. Theoretical analysis is made on the factors involved in the design of stack actuators. At the end of the paper, a stack actuator is designed according to theoretical analysis. Experiments of an adaptive trailing edge flap model are introduced to verify the feasibility of the model.

  18. Least Action Principle in Gait

    Fan, Yifang; Fan, Yubo; Xu, Zongxiang; Li, Zhiyu; Luo, Donglin


    We apply the laws of human gait vertical ground reaction force and discover the existence of the phenomenon of least action principle in gait. Using a capacitive mat transducer system, we obtain the variations of human gait vertical ground reaction force and establish a structure equation for the resultant of such a force. Defining the deviation of vertical force as an action function, we observe from our gait optimization analysis the least action principle at half of the stride time. We develop an evaluation index of mechanical energy consumption based upon the least action principle in gait. We conclude that these observations can be employed to enhance the accountability of gait evaluation.

  19. The active principle region of Buyang Huanwu decoction induced differentiation of bone marrow-derived mesenchymal stem cells into neural-like cells Superior effects over original formula of Buyang Huanwu decoction

    Jinghui Zheng; Yi Wan; Jianhuai Chi; Dekai Shen; Tingting Wu; Weimin Li; Pengcheng Du


    The present study induced in vitro-cultured passage 4 bone marrow-derived mesenchymal stem cells to differentiate into neural-like cells with a mixture of alkaloid, polysaccharide, aglycone, glycoside, essential oils, and effective components of Buyang Huanwu decoction (active principle region of decoction for invigorating yang for recuperation). After 28 days, nestin and neuron-specific enolase were expressed in the cytoplasm. Reverse transcription-PCR and western blot analyses showed that nestin and neuron-specific enolase mRNA and protein expression was greater in the active principle region group compared with the original formula group. Results demonstrated that the active principle region of Buyang Huanwu decoction induced greater differentiation of rat bone marrow-derived mesenchymal stem cells into neural-like cells in vitro than the original Buyang Huanwu decoction formula.

  20. Discussion on the creating principle of primary school activity space%初探小学活动空间的营造原则



    Based on the current actual requirements,combining with two excellent design examples of Tsinghua University elementary school and Xiaoquan national primary school,from the convenience,diversity,size appropriate three aspects of space activities discussed the creating princi-ple of primary school activity space,made the design scheme to meet the space environment and atmosphere of learning and communication,pro-moted the healthy development of student’s body and mind.%立足于现阶段的现实需求,结合清华大学附小和孝泉民族小学两个优秀的设计实例,从活动空间的便捷性、多样性、尺度的适宜性三个方面探讨了小学活动空间的营造原则,使设计方案能满足学习和交往的空间环境和氛围,促进学生身心的健康发展。

  1. Principles Guiding Vocabulary Learning through Extensive Reading

    Nation, Paul


    Extensive reading is one of a range of activities that can be used in a language learning course. Ideally, the choice of activities to go into a course should be guided by principles which are well supported by research. Similarly, the way each of those activities is used should be guided by well-justified principles. In this article, we look at…

  2. Principled Missing Data Treatments.

    Lang, Kyle M; Little, Todd D


    We review a number of issues regarding missing data treatments for intervention and prevention researchers. Many of the common missing data practices in prevention research are still, unfortunately, ill-advised (e.g., use of listwise and pairwise deletion, insufficient use of auxiliary variables). Our goal is to promote better practice in the handling of missing data. We review the current state of missing data methodology and recent missing data reporting in prevention research. We describe antiquated, ad hoc missing data treatments and discuss their limitations. We discuss two modern, principled missing data treatments: multiple imputation and full information maximum likelihood, and we offer practical tips on how to best employ these methods in prevention research. The principled missing data treatments that we discuss are couched in terms of how they improve causal and statistical inference in the prevention sciences. Our recommendations are firmly grounded in missing data theory and well-validated statistical principles for handling the missing data issues that are ubiquitous in biosocial and prevention research. We augment our broad survey of missing data analysis with references to more exhaustive resources.

  3. Principles of copula theory

    Durante, Fabrizio


    Principles of Copula Theory explores the state of the art on copulas and provides you with the foundation to use copulas in a variety of applications. Throughout the book, historical remarks and further readings highlight active research in the field, including new results, streamlined presentations, and new proofs of old results.After covering the essentials of copula theory, the book addresses the issue of modeling dependence among components of a random vector using copulas. It then presents copulas from the point of view of measure theory, compares methods for the approximation of copulas,

  4. Intruder Activity Analysis under Unreliable Sensor Networks

    Tae-Sic Yoo; Humberto E. Garcia


    This paper addresses the problem of counting intruder activities within a monitored domain by a sensor network. The deployed sensors are unreliable. We characterize imperfect sensors with misdetection and false-alarm probabilities. We model intruder activities with Markov Chains. A set of Hidden Markov Models (HMM) models the imperfect sensors and intruder activities to be monitored. A novel sequential change detection/isolation algorithm is developed to detect and isolate a change from an HMM representing no intruder activity to another HMM representing some intruder activities. Procedures for estimating the entry time and the trace of intruder activities are developed. A domain monitoring example is given to illustrate the presented concepts and computational procedures.

  5. High-Throughput Analysis of Enzyme Activities

    Lu, Guoxin [Iowa State Univ., Ames, IA (United States)


    High-throughput screening (HTS) techniques have been applied to many research fields nowadays. Robot microarray printing technique and automation microtiter handling technique allows HTS performing in both heterogeneous and homogeneous formats, with minimal sample required for each assay element. In this dissertation, new HTS techniques for enzyme activity analysis were developed. First, patterns of immobilized enzyme on nylon screen were detected by multiplexed capillary system. The imaging resolution is limited by the outer diameter of the capillaries. In order to get finer images, capillaries with smaller outer diameters can be used to form the imaging probe. Application of capillary electrophoresis allows separation of the product from the substrate in the reaction mixture, so that the product doesn't have to have different optical properties with the substrate. UV absorption detection allows almost universal detection for organic molecules. Thus, no modifications of either the substrate or the product molecules are necessary. This technique has the potential to be used in screening of local distribution variations of specific bio-molecules in a tissue or in screening of multiple immobilized catalysts. Another high-throughput screening technique is developed by directly monitoring the light intensity of the immobilized-catalyst surface using a scientific charge-coupled device (CCD). Briefly, the surface of enzyme microarray is focused onto a scientific CCD using an objective lens. By carefully choosing the detection wavelength, generation of product on an enzyme spot can be seen by the CCD. Analyzing the light intensity change over time on an enzyme spot can give information of reaction rate. The same microarray can be used for many times. Thus, high-throughput kinetic studies of hundreds of catalytic reactions are made possible. At last, we studied the fluorescence emission spectra of ADP and obtained the detection limits for ADP under three different

  6. Neutron activation analysis of wheat samples

    Galinha, C. [CERENA-IST, Technical University of Lisbon, Av. Rovisco Pais 1, 1049-001 Lisboa (Portugal); Instituto Tecnoclogico e Nuclear, URSN, E.N. 10, 2686-953 Sacavem (Portugal); Anawar, H.M. [Instituto Tecnoclogico e Nuclear, URSN, E.N. 10, 2686-953 Sacavem (Portugal); Freitas, M.C., E-mail: [Instituto Tecnoclogico e Nuclear, URSN, E.N. 10, 2686-953 Sacavem (Portugal); Pacheco, A.M.G. [CERENA-IST, Technical University of Lisbon, Av. Rovisco Pais 1, 1049-001 Lisboa (Portugal); Almeida-Silva, M. [Instituto Tecnoclogico e Nuclear, URSN, E.N. 10, 2686-953 Sacavem (Portugal); Coutinho, J.; Macas, B.; Almeida, A.S. [INRB/INIA-Elvas, National Institute of Biological Resources, Est. Gil Vaz, 7350-228 Elvas (Portugal)


    The deficiency of essential micronutrients and excess of toxic metals in cereals, an important food items for human nutrition, can cause public health risk. Therefore, before their consumption and adoption of soil supplementation, concentrations of essential micronutrients and metals in cereals should be monitored. This study collected soil and two varieties of wheat samples-Triticum aestivum L. (Jordao/bread wheat), and Triticum durum L. (Marialva/durum wheat) from Elvas area, Portugal and analyzed concentrations of As, Cr, Co, Fe, K, Na, Rb and Zn using Instrumental Neutron Activation Analysis (INAA) to focus on the risk of adverse public health issues. The low variability and moderate concentrations of metals in soils indicated a lower significant effect of environmental input on metal concentrations in agricultural soils. The Cr and Fe concentrations in soils that ranged from 93-117 and 26,400-31,300 mg/kg, respectively, were relatively high, but Zn concentration was very low (below detection limit <22 mg/kg) indicating that soils should be supplemented with Zn during cultivation. The concentrations of metals in roots and straw of both varieties of wheat decreased in the order of K>Fe>Na>Zn>Cr>Rb>As>Co. Concentrations of As, Co and Cr in root, straw and spike of both varieties were higher than the permissible limits with exception of a few samples. The concentrations of Zn in root, straw and spike were relatively low (4-30 mg/kg) indicating the deficiency of an essential micronutrient Zn in wheat cultivated in Portugal. The elemental transfer from soil to plant decreases with increasing growth of the plant. The concentrations of various metals in different parts of wheat followed the order: Root>Straw>Spike. A few root, straw and spike samples showed enrichment of metals, but the majority of the samples showed no enrichment. Potassium is enriched in all samples of root, straw and spike for both varieties of wheat. Relatively to the seed used for cultivation

  7. Karyotype Analysis Activity: A Constructivist Learning Design

    Ahmed, Noveera T.


    This classroom activity is based on a constructivist learning design and engages students in physically constructing a karyotype of three mock patients. Students then diagnose the chromosomal aneuploidy based on the karyotype, list the symptoms associated with the disorder, and discuss the implications of the diagnosis. This activity is targeted…

  8. The Analysis of Activated Carbon Regeneration Technologies



    A series of methods for activated carbon regeneration were briefly introduced.Such as thermal regeneration,chemical regeneration,biochemical regeneration,and newly supercritical fluid regeneration, electrochemical regeneration,light-catalyzed regeneration,and microwave radiation method,and the developing trend of activated carbon regeneration was predicted.

  9. Principles of exploratory data analysis in problem solving: what can we learn from a well-known case?

    de Mast, J.; Kemper, B.P.H.


    Exploratory data analysis (EDA) is sometimes suggested as a hypothesis identification approach. It is often used as such in problem solving and consists of the analysis of observational data, often collected without well-defined hypotheses, with the purpose of finding clues that could inspire ideas

  10. Comparative Analysis of Ranking and Accreditation: Exploring a Set of Universal Principles for Higher Education Quality Assurance

    Steve O. Michael


    Full Text Available All universities are not equal. Universities are not equal in size, scope, curricular offerings, and resources. More importantly, they are not equal in mission, scale of operation, productivity, and quality. Even two universities located within the same geographical locations may differ considerably in productivity and quality let alone those that are located a world apart. Given the wide range of differences in the environments of these institutions, in the political systems within which they reside, in the economic contexts within which they operate, and in their historical origins, the variations among higher education institutions are understandable and frankly speaking should be anticipated. Given the differences among institutions, how should we approach the issue of their quality? In response to this question, the benefits and process of rankings are compared to that of accreditation. The implications of rankings and accreditation for two “randomly” selected institutions in the US are discussed. By reviewing the standards used by two accrediting commissions, a set of principles that is applicable universally is recommended.

  11. First principles analysis of the Abraham-Minkowski controversy for the momentum of light in general linear media

    Ramos, Tomás; Obukhov, Yuri N


    We study the problem of the definition of the energy-momentum tensor of light in general moving media with linear constitutive law. Using the basic principles of classical field theory, we show that for the correct understanding of the problem, one needs to carefully distinguish situations when the material medium is modeled either as a background on which light propagates or as a dynamical part of the total system. In the former case, we prove that the (generalized) Belinfante-Rosenfeld (BR) tensor for the electromagnetic field coincides with the Minkowski tensor. We derive a complete set of balance equations for this open system and show that the symmetries of the background medium are directly related to the conservation of the Minkowski quantities. In particular, for isotropic media, the angular momentum of light is conserved despite of the fact that the Minkowski tensor is non-symmetric. For the closed system of light interacting with matter, we model the material medium as a relativistic non-dissipative...




    本文通过阐释HCD的概念由来和发展历程,让设计者更深刻地了解其产生的时代背景和现行设计界对其发展做出的新的尝试和努力。在其设计的指导原则下,列举了IDEO、DESIGN for AMERICA和Frog design三家设计组织对其设计流程方法的新的探索,通过总结相似点,提出并阐释了基于HCD设计流程的四个阶段特征,以此为从事HCD相关领域的设计者提供参考和借鉴。%This paper explains the origin and development process of HCD, alowing the designers to have a more profound understanding of the background and efforts made by the current design community. Under the guidance of its design principle, the article enumerates methods of the design process of new exploration of the three design organization, the IDEO, the DESIGN for AMERICA and Frog DESIGN, by summarizing the similarities, and putting forward and explain the flow characteristics of the four stages of HCD design to provide referable value for the designers engaged in related fields of HCD.


    Arkadiusz Gudaniec


    Full Text Available In ancient times, people pondered “cosmic love” (eros, philotes, thymos, i.e., the universal power that underlies the phenomena of the universe. The force of love extends to all things, including man and his action. Philosophers remarked rather early that love is, as it were, the foundation for the phenomena and actions that are experienced. As love is both of the character of a source and is strongly present in its manifestations, it turns out to be something that, on the one hand, is best known, but on the other hand, not easy to understand. In parallel, people also considered the strictly personal form of love—philia, whereby people are joined with each other in a special relation, which is friendship (Aristotle started this conception. The analogical scholastic conception of love was an interesting combination of those two tendencies; love is the foundation of action and in the metaphysical order it becomes the principle that explains the domain of being that we call dynamism. This article discusses Thomas Aquinas’ doctrine of love; first, it analyzes love’s relationship with action, end, and knowledge, then, secondly, investigates the place of love in the order of the causes of action.

  14. Comprehending ecological and economic sustainability: comparative analysis of stability principles in the biosphere and free market economy.

    Makarieva, Anastassia M; Gorshkov, Victor G; Li, Bai-Lian


    The global environmental imperative demands urgent actions on ecological stabilization, yet the global scale of such actions is persistently insufficient. This calls for investigating why the world economy appears to be so fearful of any potential environmental expenditure. Using the formalism of Lyapunov potential function it is shown that the stability principles for biomass in the ecosystem and for employment in economics are mathematically similar. The ecosystem has a stable and unstable stationary state with high (forest) and low (grasslands) biomass, respectively. In economics, there is a stable stationary state with high employment in mass production of conventional goods sold at low cost price, and an unstable stationary state with lower employment in production of novel products of technological progress sold at higher prices. An additional stable state is described for economics with very low employment in production of life essentials, such as energy and raw materials that are sold at greatly inflated prices. In this state the civilization pays 10% of global GDP for energy produced by a negligible minority of the working population (currently approximately 0.2%) and sold at prices exceeding the cost price by 40 times, a state when any extra expenditures of whatever nature appear intolerable. The reason lies in the fundamental shortcoming of economic theory, which allows for economic ownership over energy sources. This is shown to be equivalent to equating measurable variables of different dimensions (stores and fluxes), which leads to effective violation of the laws of energy and matter conservation in modern economics.

  15. Detailed Analysis of Motor Unit Activity

    Nikolic, Mile; Sørensen, John Aasted; Dahl, Kristian


    System for decomposition of EMG signals intotheir constituent motor unit potentials and their firing patterns.The aim of the system is detailed analysis ofmotor unit variability.......System for decomposition of EMG signals intotheir constituent motor unit potentials and their firing patterns.The aim of the system is detailed analysis ofmotor unit variability....

  16. Development of educational program for neutron activation analysis

    Chung, Yong Sam; Moon, Jong Hwa; Kim, Sun Ha; Ryel, Sung; Kang, Young Hwan; Lee, Kil Yong; Yeon, Yeon Yel; Cho, Seung Yeon


    This technical report is developed to apply an educational and training program for graduate student and analyst utilizing neutron activation analysis. The contents of guide book consists of five parts as follows; introduction, gamma-ray spectrometry and measurement statistics, its applications, to understand of comprehensive methodology and to utilize a relevant knowledge and information on neutron activation analysis.

  17. Self-healing properties of nanocrystalline materials: a first-principles analysis of the role of grain boundaries.

    Xu, Jian; Liu, Jian-Bo; Li, Shun-Ning; Liu, Bai-Xin; Jiang, Yong


    Understanding the self-healing mechanisms of defects in nanocrystalline materials is of particular importance for developing structural materials that can support the extended lifetime of components under extremely hostile conditions in nuclear reactors. Since grain boundaries are prevalent in nanocrystalline materials, they must affect, to some extent, the overall self-healing properties and the resultant mechanical responses. In the present work, first principles calculations are carried out to investigate the energetic landscape of point defects (i.e. self-interstitials, He-interstitials, and vacancies) induced by the irradiation damage and the kinetics of the self-healing process in the vicinity of grain boundaries (GBs) in copper, focusing on six symmetric tilt grain boundaries that vary in their energies. Our results indicate that the interaction of vacancies with the self-interstitial- and He-interstitial-loaded GBs is very sensitive to the GB character. Low-energy GBs are generally accompanied by a higher propensity for self-healing behavior, in which the inter-granular interstitials and intra-granular vacancies recombine with each other. The recombination process is proved to be regulated by two mechanisms: the interstitial emission mechanism and the vacancy mediated mechanism. For low-energy GBs, the former mechanism demonstrates its efficiency in describing the atomic motion, while for the high-energy ones, the latter turns out to be superior. With the aid of these mechanisms, we conclude that low-energy GBs are comparatively more radiation-resistant than the high-energy counterparts, which may shed light on the rational design of high-performance structural materials based on nanocrystalline alloys.

  18. "Macbeth"Conversation Analysis under Cooperative Violate Principle%会话合作违反原则下《麦克白》对话分析

    杨春叶; 许美婷


    《麦克白》是莎士比亚的四大悲剧之一。对《麦克白》的研究受国内外学者青睐;会话合作原则是格莱斯的关于语言学研究的主要理论。本文运用会话合作违反原则分析《麦克白》对话,旨在加深对此悲剧的理解及探究人际交往中合适的交流方式。%"Macbeth"is one of Shakespeare's greatest tragedies. For"Macbeth"research by scholars pro-Lai;Grice's Coop-erative Principle is the main theory of linguistics. In this paper, in violation of the principles of conversation analysis coop-eration"Macbeth"dialogue aimed at deepening the understanding of this tragedy and to explore appropriate interpersonal communication.

  19. Activity Landscape Plotter: A Web-based Application for the Analysis of Structure-Activity Relationships.

    González-Medina, Mariana; Méndez-Lucio, Oscar; Medina-Franco, Jose Luis


    Activity landscape modeling is a powerful method for the quantitative analysis of structure-activity relationships. This cheminformatics area is in continuous growth and several quantitative and visual approaches are constantly being developed. However, these approaches often fall into disuse due to their limited access. Herein, we present Activity Landscape Plotter as the first freely available web-based tool to automatically analyze structure-activity relationships of compound data sets. Based on the concept of activity landscape modeling, the online service performs pair-wise structure and activity relationships from an input data set supplied by the user. For visual analysis, Activity Landscape Plotter generates Structure-Activity Similarity and Dual Activity Difference maps. The user can interactively navigate through the maps and export all the pairwise structure-activity information as comma delimited files. Activity Landscape Plotter is freely accessible at

  20. Ecological Momentary Assessments and Automated Time Series Analysis to Promote Tailored Health Care: A Proof-of-Principle Study

    Emerencia, Ando C; Bos, Elisabeth H; Rosmalen, Judith GM; Riese, Harriëtte; Aiello, Marco; Sytema, Sjoerd; de Jonge, Peter


    Background Health promotion can be tailored by combining ecological momentary assessments (EMA) with time series analysis. This combined method allows for studying the temporal order of dynamic relationships among variables, which may provide concrete indications for intervention. However, application of this method in health care practice is hampered because analyses are conducted manually and advanced statistical expertise is required. Objective This study aims to show how this limitation can be overcome by introducing automated vector autoregressive modeling (VAR) of EMA data and to evaluate its feasibility through comparisons with results of previously published manual analyses. Methods We developed a Web-based open source application, called AutoVAR, which automates time series analyses of EMA data and provides output that is intended to be interpretable by nonexperts. The statistical technique we used was VAR. AutoVAR tests and evaluates all possible VAR models within a given combinatorial search space and summarizes their results, thereby replacing the researcher’s tasks of conducting the analysis, making an informed selection of models, and choosing the best model. We compared the output of AutoVAR to the output of a previously published manual analysis (n=4). Results An illustrative example consisting of 4 analyses was provided. Compared to the manual output, the AutoVAR output presents similar model characteristics and statistical results in terms of the Akaike information criterion, the Bayesian information criterion, and the test statistic of the Granger causality test. Conclusions Results suggest that automated analysis and interpretation of times series is feasible. Compared to a manual procedure, the automated procedure is more robust and can save days of time. These findings may pave the way for using time series analysis for health promotion on a larger scale. AutoVAR was evaluated using the results of a previously conducted manual analysis

  1. Analysis of the Principle of Rational Use of Mass Communication Information%大众传播信息合理使用原则分析



    The principle of the rational use of the copyright of mass communication is an importamt legal system to protect the right of the social public and individuals to use information. However, this system is facing severe challenges both in technology and in benefit. This paper attempts to analyzes the problems in the principle of rational use, such as the principle of judgement, abuse restriction and the principle of rational use under the network communication conditions.

  2. Teaching-Learning Activity Modeling Based on Data Analysis

    Kyungrog Kim


    Full Text Available Numerous studies are currently being carried out on personalized services based on data analysis to find and provide valuable information about information overload. Furthermore, the number of studies on data analysis of teaching-learning activities for personalized services in the field of teaching-learning is increasing, too. This paper proposes a learning style recency-frequency-durability (LS-RFD model for quantified analysis on the level of activities of learners, to provide the elements of teaching-learning activities according to the learning style of the learner among various parameters for personalized service. This is to measure preferences as to teaching-learning activity according to recency, frequency and durability of such activities. Based on the results, user characteristics can be classified into groups for teaching-learning activity by categorizing the level of preference and activity of the learner.

  3. Faculty Activity Analysis in the Universidad Tecnica Del Estado Campuses.

    Karadima, Oscar

    An analysis of academic activities of college faculty at the eight campuses of Chile's Universidad Tecnica del Estado was conducted. Activities were grouped into seven categories: direct teaching, indirect teaching, research, community services, faculty development, academic administration, and other activities. Following the narrative…

  4. Physico-chemical studies on the evaluation of the antioxidant activity of herbal extracts and active principles of some Indian medicinal plants.

    Adhikari, Soumyakanti; Indira Priyadarsini, Kavirayani; Mukherjee, Tulsi


    Understanding of the efficacy and mechanism for the reaction of the biologically important radicals with natural and/or synthetic antioxidants is the first step towards the development of future therapeutic agents. The kinetic parameters e.g., formation and decay rate constants predict the efficacy of an antioxidant and its fate after reaction. These parameters also dictate the ease with which competing reactions would occur in a bio-environment. The spectroscopic parameters provide the clue to the site of free radical attack to these antioxidants. Here, in this article an attempt has been made to show the use of physico-chemical methods in the evaluation of antioxidant activity of some important medicinal plants commonly used in India and the subcontinent. The systems chosen here for discussions are herbal extracts as such, curcumin from turmeric, methoxy phenols from Indian spices, dehydrogingerdione from ginger and bakuchiol from Psoralea corylifolia. All the examples shown in this article illustrate the potential of the pulse radiolysis coupled with kinetic spectroscopy and other physicochemical techniques for the study of antioxidants either in the form of mixture as in herbal extract or as an isolated compound.

  5. Introduction of Prompt Gamma Thermal Neutron Activation Analysis at CARR

    WANG; Xing-hua; XIAO; Cai-jin; ZHANG; Gui-ying; YAO; Yong-gang; JIN; Xiang-chun; WANG; Ping-sheng; HUA; Long; NI; Bang-fa


    CARR will provide with maximal neutron flux in Asia,the third of the world.By using the high quality neutron beam and the advanced international experience,Prompt Gamma Neutron Activation Analysis(PGNAA)facility will be setup at high level.PGNAA on CARR will promote the development of nuclear analysis technology and improve Chinese status in the nuclear analysis field.

  6. 基于Pushover原理的钢框架静力弹塑性分析%Static elastoplastic analysis of steel frame based on Pushover principle

    汪金祥; 肖亚明; 刘顺; 董文秀


    Pushover分析是实现结构性态设计目标的方法之一,文章阐述了SAP2000中Pushover分析的基本原理,并根据我国最新的抗震规范,介绍了Pushover分析的计算步骤。在此基础上,利用1个钢框架结构实例进行说明,得出了包括底部剪力-顶部位移关系曲线、层间位移角和结构破坏塑性铰分布的分析结果,表明Pushover分析是当前对钢框架结构在罕遇地震下进行弹性塑性分析的有效方法。%Pushover analysis is an important method to achieve the goal of performance-based seismic design .Based on the latest China code for seismic design ,the principles and procedures of SAP2000 Pushover analysis are reviewed .By means of SAP2000 ,a case of steel frame is presented .With the results of the base shear force-top displacement ,layer displacement angle and distribution of plastic hinges ,it is proved that the Pushover analysis is effective in the elastoplastic analysis of the steel frame structure under rare earthquakes .

  7. Opportunities for innovation in neutron activation analysis

    Bode, P.


    Neutron activation laboratories worldwide are at a turning point at which new staff has to be found for the retiring pioneers from the 1960s–1970s. A scientific career in a well-understood technique, often characterized as ‘mature’ may only be attractive to young scientists if still challenges for f

  8. Design professional activity analysis in design management

    Claudia de Souza Libanio


    Full Text Available Design use perception, as an essential element for achieving competitive advantage, also suggests the need to manage the design activities in companies. However, a few is discussed about the activity of these design professionals who participate in this process, their roles, functions and competencies, including  their connections to a company and other involved sectors. This article aims to analyze, during the design management processes, the work relations of design professionals connected to organizations both internal and externally, in order to comprehend the structure and intervenient factors on the activity of these professionals, as well as the interactions with their main coworkers. The methodology was exploratory and qualitative, using in-depth interviews with three design professionals. Subsequently, the responses were analyzed allowing the comparison of these obtained data to the theoretical bases researched. Through this case study, it was possible to realize the aspects and the structure of the design professional activity, connected intern and externally to organizations, as well as its relations with the main coworkers.

  9. Principles of tendon transfers.

    Coulet, B


    Tendon transfers are carried out to restore functional deficits by rerouting the remaining intact muscles. Transfers are highly attractive in the context of hand surgery because of the possibility of restoring the patient's ability to grip. In palsy cases, tendon transfers are only used when a neurological procedure is contraindicated or has failed. The strategy used to restore function follows a common set of principles, no matter the nature of the deficit. The first step is to clearly distinguish between deficient muscles and muscles that could be transferred. Next, the type of palsy will dictate the scope of the program and the complexity of the gripping movements that can be restored. Based on this reasoning, a surgical strategy that matches the means (transferable muscles) with the objectives (functions to restore) will be established and clearly explained to the patient. Every paralyzed hand can be described using three parameters. 1) Deficient segments: wrist, thumb and long fingers; 2) mechanical performance of muscles groups being revived: high energy-wrist extension and finger flexion that require strong transfers with long excursion; low energy-wrist flexion and finger extension movements that are less demanding mechanically, because they can be accomplished through gravity alone in some cases; 3) condition of the two primary motors in the hand: extrinsics (flexors and extensors) and intrinsics (facilitator). No matter the type of palsy, the transfer surgery follows the same technical principles: exposure, release, fixation, tensioning and rehabilitation. By performing an in-depth analysis of each case and by following strict technical principles, tendon transfer surgery leads to reproducible results; this allows the surgeon to establish clear objectives for the patient preoperatively.

  10. Active Shape Analysis of Mandibular Growth

    Hilger, Klaus Baggesen; Larsen, Rasmus; Kreiborg, Sven;


    This work contains a clinical validation using biological landmarks of a Geometry Constrained Diffusion registration of mandibular surfaces. Canonical Correlations Analysis is extended to analyse 3D landmarks and the correlations are used as similarity measures for landmark clustering. A novel Ac...

  11. Structure, Principles and Failure Analysis of X-ray Tube%X射线球管的结构、原理及常见故障分析



    The article described structure, working principles, specification characteristies and technical parameters of X-ray tube which was important to set the technical parameters of X-ray tube in scientific and rational way, and make X-ray tube maintain in the best condition. Meanwhile. the article 8ummarized the methods about failure analysis and troubleshooting of X-ray tube.[Chinese Medical Equipment Journal,2011 , 32 ( 3) : 124-125]%介绍了X射线球管的结构、工作原理、规格特性和技术参数,指出使用中科学合理的设定X射线机技术参数、保持其处于最佳状态具有重要意义.归纳总结了X线球管故障分析和排除常见方法.

  12. Principles of neural information processing

    Seelen, Werner v


    In this fundamental book the authors devise a framework that describes the working of the brain as a whole. It presents a comprehensive introduction to the principles of Neural Information Processing as well as recent and authoritative research. The books´ guiding principles are the main purpose of neural activity, namely, to organize behavior to ensure survival, as well as the understanding of the evolutionary genesis of the brain. Among the developed principles and strategies belong self-organization of neural systems, flexibility, the active interpretation of the world by means of construction and prediction as well as their embedding into the world, all of which form the framework of the presented description. Since, in brains, their partial self-organization, the lifelong adaptation and their use of various methods of processing incoming information are all interconnected, the authors have chosen not only neurobiology and evolution theory as a basis for the elaboration of such a framework, but also syst...

  13. Digital image processing and analysis for activated sludge wastewater treatment.

    Khan, Muhammad Burhan; Lee, Xue Yong; Nisar, Humaira; Ng, Choon Aun; Yeap, Kim Ho; Malik, Aamir Saeed


    Activated sludge system is generally used in wastewater treatment plants for processing domestic influent. Conventionally the activated sludge wastewater treatment is monitored by measuring physico-chemical parameters like total suspended solids (TSSol), sludge volume index (SVI) and chemical oxygen demand (COD) etc. For the measurement, tests are conducted in the laboratory, which take many hours to give the final measurement. Digital image processing and analysis offers a better alternative not only to monitor and characterize the current state of activated sludge but also to predict the future state. The characterization by image processing and analysis is done by correlating the time evolution of parameters extracted by image analysis of floc and filaments with the physico-chemical parameters. This chapter briefly reviews the activated sludge wastewater treatment; and, procedures of image acquisition, preprocessing, segmentation and analysis in the specific context of activated sludge wastewater treatment. In the latter part additional procedures like z-stacking, image stitching are introduced for wastewater image preprocessing, which are not previously used in the context of activated sludge. Different preprocessing and segmentation techniques are proposed, along with the survey of imaging procedures reported in the literature. Finally the image analysis based morphological parameters and correlation of the parameters with regard to monitoring and prediction of activated sludge are discussed. Hence it is observed that image analysis can play a very useful role in the monitoring of activated sludge wastewater treatment plants.

  14. Statistical Contact Angle Analyses with the High-Precision Drop Shape Analysis (HPDSA) Approach: Basic Principles and Applications

    Florian Heib; Michael Schmitt


    Surface science, which includes the preparation, development and analysis of surfaces and coatings, is essential in both fundamental and applied as well as in engineering and industrial research. Contact angle measurements using sessile drop techniques are commonly used to characterize coated surfaces or surface modifications. Well-defined surfaces structures at both nanoscopic and microscopic level can be achieved but the reliable characterization by means of contact angle measurements and t...

  15. Computational Models for Analysis of Illicit Activities

    Nizamani, Sarwat

    result in a fully evolved network. This method of network evolution can help intelligence security analysts to understand the structure of the network. For suspicious emails detection and email author identification, a cluster-based text classification model has been proposed. The model outperformed...... traditional models for both of the tasks. Apart from these globally organized crimes and cybercrimes, there happen specific world issues which affect geographic locations and take the form of bursts of public violence. These kinds of issues have received little attention by the academicians. These issues have...... to describe the phenomenon of contagious public outrage, which eventually leads to the spread of violence following a disclosure of some unpopular political decisions and/or activity. The results shed a new light on terror activity and provide some hint on how to curb the spreading of violence within...

  16. Active magnetic radiation shielding system analysis and key technologies.

    Washburn, S A; Blattnig, S R; Singleterry, R C; Westover, S C


    Many active magnetic shielding designs have been proposed in order to reduce the radiation exposure received by astronauts on long duration, deep space missions. While these designs are promising, they pose significant engineering challenges. This work presents a survey of the major systems required for such unconfined magnetic field design, allowing the identification of key technologies for future development. Basic mass calculations are developed for each system and are used to determine the resulting galactic cosmic radiation exposure for a generic solenoid design, using a range of magnetic field strength and thickness values, allowing some of the basic characteristics of such a design to be observed. This study focuses on a solenoid shaped, active magnetic shield design; however, many of the principles discussed are applicable regardless of the exact design configuration, particularly the key technologies cited.

  17. Regulatory activities of government: analysis of determinants

    Primož Pevcin


    Full Text Available International comparisons show that large cross-country differences exist in the overall macro extent of regulation of the economy. In this context, the main purpose of the article is to investigate, why such differences exist by identifying and empirically verifying the effect of various factors that could potentially shape those differences. Empirical analysis based on the sample of 32 developed and democratic countries revealed that almost 70 % of variation in the macro extent of regulation could be explained with 7 statistically significant explanatory variables. The econometric analysis revealed that the macro extent of regulation decreases with income inequality in society, with the level of economic development, with the sizeof economy, with the share of transfer spending in GDP and with the share of government employment in labour force. On the other hand, the extent of regulation is positively related to government ownership of enterprises and to presidential political regime

  18. Principles of safety pharmacology.

    Pugsley, M K; Authier, S; Curtis, M J


    Safety Pharmacology is a rapidly developing discipline that uses the basic principles of pharmacology in a regulatory-driven process to generate data to inform risk/benefit assessment. The aim of Safety Pharmacology is to characterize the pharmacodynamic/pharmacokinetic (PK/PD) relationship of a drug's adverse effects using continuously evolving methodology. Unlike toxicology, Safety Pharmacology includes within its remit a regulatory requirement to predict the risk of rare lethal events. This gives Safety Pharmacology its unique character. The key issues for Safety Pharmacology are detection of an adverse effect liability, projection of the data into safety margin calculation and finally clinical safety monitoring. This article sets out to explain the drivers for Safety Pharmacology so that the wider pharmacology community is better placed to understand the discipline. It concludes with a summary of principles that may help inform future resolution of unmet needs (especially establishing model validation for accurate risk assessment). Subsequent articles in this issue of the journal address specific aspects of Safety Pharmacology to explore the issues of model choice, the burden of proof and to highlight areas of intensive activity (such as testing for drug-induced rare event liability, and the challenge of testing the safety of so-called biologics (antibodies, gene therapy and so on.).

  19. Principles of Mechanical Excavation

    Lislerud, A. [Tamrock Corp., Tampere (Finland)


    Mechanical excavation of rock today includes several methods such as tunnel boring, raiseboring, roadheading and various continuous mining systems. Of these raiseboring is one potential technique for excavating shafts in the repository for spent nuclear fuel and dry blind boring is promising technique for excavation of deposition holes, as demonstrated in the Research Tunnel at Olkiluoto. In addition, there is potential for use of other mechanical excavation techniques in different parts of the repository. One of the main objectives of this study was to analyze the factors which affect the feasibility of mechanical rock excavation in hard rock conditions and to enhance the understanding of factors which affect rock cutting so as to provide an improved basis for excavator performance prediction modeling. The study included the following four main topics: (a) phenomenological model based on similarity analysis for roller disk cutting, (b) rock mass properties which affect rock cuttability and tool life, (c) principles for linear and field cutting tests and performance prediction modeling and (d) cutter head lacing design procedures and principles. As a conclusion of this study, a test rig was constructed, field tests were planned and started up. The results of the study can be used to improve the performance prediction models used to assess the feasibility of different mechanical excavation techniques at various repository investigation sites. (orig.). 21 refs.

  20. Solutions for complex, multi data type and multi tool analysis: principles and applications of using workflow and pipelining methods.

    Munro, Robin E J; Guo, Yike


    Analytical workflow technology, sometimes also called data pipelining, is the fundamental component that provides the scalable analytical middleware that can be used to enable the rapid building and deployment of an analytical application. Analytical workflows enable researchers, analysts and informaticians to integrate and access data and tools from structured and non-structured data sources so that analytics can bridge different silos of information; compose multiple analytical methods and data transformations without coding; rapidly develop applications and solutions by visually constructing analytical workflows that are easy to revise should the requirements change; access domain-specific extensions for specific projects or areas, for example, text extraction, visualisation, reporting, genetics, cheminformatics, bioinformatics and patient-based analytics; automatically deploy workflows directly into web portals and as web services to be part of a service-oriented architecture (SOA). By performing workflow building, using a middleware layer for data integration, it is a relatively simple exercise to visually design an analytical process for data analysis and then publish this as a service to a web browser. All this is encapsulated into what can be referred to as an 'Embedded Analytics' methodology which will be described here with examples covering different scientifically focused data analysis problems.

  1. Ranking and analysis administrative barriers of fundamental principles and rights at work from the perspective of employers by using parametrical analysis and the TOPSIS method

    Gholam Reza Bordbar


    Full Text Available ILO, adopted and communicated several types of document which include Conventions, recommendations, resolutions and statements etc.among all of them, convention has a special place because the members states accept duties and obligations. Among these conventions, those conventions that are related to the fundamental rights of labor had special importance and prestige. Member countries of the Organization like Iran are required to implement the relevant commitments. this study aimed to analyze administrative obstacles of the Fundamental Principles and Rights at Work by getting weight to problems and ranking them. The result of study show that Prohibition of child labor is more important than other aspects of Fundamental Principles and Rights at Work. in aspect of child labor most important obstacle was "red tape" ,in others categories result was as follow: in lack of collective bargaining most important obstacle was made emotional decisions, in forced labor most important obstacle was distrust of other workers, in gender discrimination most important obstacle was Working environment, in people inequality most important obstacle was Subjective judgments manager.

  2. Correlating Acid Properties and Catalytic Function: A First-Principles Analysis of Alcohol Dehydration Pathways on Polyoxometalates

    Janik, Michael J.; Macht, Josef; Iglesia, Enrique; Neurock, Matthew


    Density functional theory calculations and reactivity data were used to examine the mechanism of alcohol dehydration on Keggin-type polyoxometalate (POM) catalysts and the influence of the POM composition and the degree of substitution of the alcohol on kinetically relevant elimination steps. Dehydration was found to proceed through E1 pathways in which the alcohol CsO bond is cleaved heterolytically via a carbeniumion transition state. Dehydration rates were found to depend on the elimination rate constant and the equilibrium constant for the formation of unreactive alcohol dimers. E2-type elimination transition states, involving concerted CsH and CsO bond cleavage, were not found. The extent of substitution at the R-carbon on the alcohol was found to lead to marked effects on elimination barriers, because substitution increases the proton affinity of the alcohol and the stability of the carbenium-ion transition state. Changes in the central and addenda atoms of the POM cluster and the presence of n-donors, a support, vicinal POM clusters, or charge-compensating cations were found to lead to changes in the deprotonation energy (DPE) of the POM cluster, activation barriers to dehydration, and the stability of the unreactive dimer. These effects are all captured in a general linear relation between activation barriers and deprotonation energy, a rigorous measure of acid strength. The explicit dependence of the E1 activation barrier on the acid deprotonation energy is much weaker than that on reactant proton affinity. This results from the more effective compensation between the acid deprotonation energy and the interaction energy between the cationic hydrocarbon fragment and the anionic POM cluster at the transition state. The direct interactions between the POM protons and the support, other POM clusters, n-donors, base probe molecules, and charge-compensating cations increased the negative charge of the oxide shell of the W12O40 conjugate base, which increased the

  3. Parsing with Principles and Probabilities

    Fordham, A; Fordham, Andrew; Crocker, Matthew


    This paper is an attempt to bring together two approaches to language analysis. The possible use of probabilistic information in principle-based grammars and parsers is considered, including discussion on some theoretical and computational problems that arise. Finally a partial implementation of these ideas is presented, along with some preliminary results from testing on a small set of sentences.

  4. Emulsion Science Basic Principles

    Leal-Calderon, Fernando; Schmitt, Véronique


    Emulsions are generally made out of two immiscible fluids like oil and water, one being dispersed in the second in the presence of surface-active compounds.They are used as intermediate or end products in a huge range of areas including the food, chemical, cosmetic, pharmaceutical, paint, and coating industries. Besides the broad domain of technological interest, emulsions are raising a variety of fundamental questions at the frontier between physics and chemistry. This book aims to give an overview of the most recent advances in emulsion science. The basic principles, covering aspects of emulsions from their preparation to their destruction, are presented in close relation to both the fundamental physics and the applications of these materials. The book is intended to help scientists and engineers in formulating new materials by giving them the basics of emulsion science.


    Lakhmili Siham


    Full Text Available The phenolic products of medicinal plants have a great pharmacological interest. This product gives the powers of medicinal plants. They are the source of several active principles widely used in modern medicine. The use of Nerium oleander in Moroccan traditional medicine is very common. Few studies have focused on the chemical analysis and phenolic compounds of this plant. For this, we investigated the mineral composition and phenolic combination of the leaves oleander and the study of the antioxidant activity. The mineral analysis shows a very high level of potassium and protein. The biochemical studies revealed a very high quantity of polyphenols in the leaves. Thus, the HPLC analysis of the phenolic fraction shows great variability of substances. The cinnamic acid is the majors compounds identified in the phenolic fraction. The other compounds identified are catechin, epicatechine, chlorogenic acid. This present study which is made for the first time showed a very important antioxidant effect, the value of IC50 (The half maximal inhibitory concentration of DPPH is 0,43 mg mL-1 for the phenolic fraction. On the other hand, the antioxydant activity of the organic extract, the methanolique fraction, n-butanolique fraction and the decoction, has a percentage of inhibition of DPPH over than 90% at a concentration of µg/mL. IC50% values are respectively 0,005 mg mL-1; 0,018 mg mL-1 and 0,005 mg mL-1.

  6. Development of common principles for the evaluation of quality characteristics of motor activity in the fitness and sports aerobics aesthetic orientation

    Galyna Artemyeva


    Full Text Available Purpose: to develop and validate methods for quantifying qualitative indicators special physical preparedness of sportsmen in fitness-aerobics and sports aesthetic orientation. Materials and Methods: an analytical synthesis of these scientific and methodical literature, the use of the theory of similarity and dimensionality, biomechanical analysis of motor activity, processing of video. Results: based on the use of similarity theory presents the methods of quantitative evaluation of qualitative characteristics of motor activity in special physical training, which allow an assessment of motor talent of the athlete and to provide objective guidance to training in particular sport. Conclusions: the presented methods quantify the qualitative indicators of the special motor preparation allow us to estimate a measure of motor gifted individual and his susceptibility to training in particular sport

  7. Mathematical analysis of complex cellular activity

    Bertram, Richard; Teka, Wondimu; Vo, Theodore; Wechselberger, Martin; Kirk, Vivien; Sneyd, James


    This book contains two review articles on mathematical physiology that deal with closely related topics but were written and can be read independently. The first article reviews the basic theory of calcium oscillations (common to almost all cell types), including spatio-temporal behaviors such as waves. The second article uses, and expands on, much of this basic theory to show how the interaction of cytosolic calcium oscillators with membrane ion channels can result in highly complex patterns of electrical spiking. Through these examples one can see clearly how multiple oscillatory processes interact within a cell, and how mathematical methods can be used to understand such interactions better. The two reviews provide excellent examples of how mathematics and physiology can learn from each other, and work jointly towards a better understanding of complex cellular processes. Review 1: Richard Bertram, Joel Tabak, Wondimu Teka, Theodore Vo, Martin Wechselberger: Geometric Singular Perturbation Analysis of Burst...

  8. Principle analysis of deceleration of the high-rise escape apparatus%高楼逃生装置的减速原理分析

    乔印虎; 苏国用; 杨杰; 龚建; 王冲


    High-rise escape apparatus is designed to help more personnel escape safely from the scene in shortest time. However, how to ensure the escaping individual decrease potential energy and kinetic energy steady and fast is the key to the design. This design uses the principle of negative feedback close-loop system to achieve pure mechanical design, uses the escape personel self weight to realize self-dece Leration. Analyze the deceleration principle to understand its structural design and working mechanism. Making finite element analysis to the important deceleration parts through solidworks Simulations oftware to detect the weakest part is beneficial to product design and production.%高楼逃生装置的设计原则是利用最短的时间,使更多的人安全地离开事发现场。此类设计所要解决的关键性难题是如何将逃生者的势能与动能平稳快速地降下来。采用负反馈闭环系统原理实现纯机械化设计,利用逃生人员自重实现自减速功能。对该装置进行减速原理进行分析,以便理解其整体结构设计与工作机理。通过Solidworks>Simulation软件对减速结构重要零件进行有限元分析,找出该减速装置最容易失效的部位,有利于产品的设计与生产。

  9. Volatile Organic Compound (VOC) Analysis For Disease Detection: Proof Of Principle For Field Studies Detecting Paratuberculosis And Brucellosis

    Knobloch, Henri; Köhler, Heike; Nicola, Commander; Reinhold, Petra; Turner, Claire; Chambers, Mark


    A proof of concept investigation was performed to demonstrate that two independent infectious diseases of cattle result in different patterns of volatile organic compounds (VOC) in the headspace of serum samples detectable using an electronic nose (e-nose). A total of 117 sera from cattle naturally infected with Mycobacterium avium subsp. paratuberculosis (paraTB, n = 43) or Brucella sp. (n = 26) and sera from corresponding control animals (n = 48) were randomly and analysed blind to infection status using a ST214 e-nose (Scensive Ltd, Leeds, UK). Samples were collected under non-standardised conditions on different farms from the UK (brucellosis) and Germany (paraTB). The e-nose could differentiate the sera from brucellosis infected, paraTB infected and healthy animals at the population level, but the technology used was not suitable for determination of the disease status of individual animals. Nevertheless, the data indicate that there are differences in the sensor responses depending on the disease status, and therefore, it shows the potential of VOC analysis from serum headspace samples for disease detection.

  10. Eggs-ploiting women: a critical feminist analysis of the different principles in transplant and fertility tourism.

    Pfeffer, Naomi


    Intergovernmental agencies have recognized that inconsistencies in the way that nation states regulate commerce in human kidneys lubricate transplant tourism, and have repeatedly exhorted recalcitrant governments of both organ-importing and organ-exporting nations to criminalize the exchange of cash for kidneys. Yet these same organizations have elected to remain silent on inconsistencies in the regulation of the trade in human eggs that lubricate fertility tourism. This article is a critical feminist analysis of this paradox. Sketches of the histories of regulation of the global markets in human kidneys and human eggs allow attribution of the different approaches to sales of kidneys and eggs to the triumph of neo-liberalism in the 1990s. Neo-liberalism supports the growth of the medical tourism industry and its niche market catering for infertility, and is responsible for exacerbating the relative disadvantage of poor and powerless women in destination countries, thereby creating the conditions for 'bioavailability', that is, the willingness to exchange body parts for cash. The paper identifies a disturbing correlation between deeply engrained conservative attitudes to women and a plentiful supply of eggs, and concludes by suggesting that what women need to lift themselves out of poverty and discrimination is secure and dignified work.

  11. Specific classification of financial analysis of enterprise activity

    Synkevych Nadiia I.


    Full Text Available Despite the fact that one can find a big variety of classifications of types of financial analysis of enterprise activity, which differ with their approach to classification and a number of classification features and their content, in modern scientific literature, their complex comparison and analysis of existing classification have not been done. This explains urgency of this study. The article studies classification of types of financial analysis of scientists and presents own approach to this problem. By the results of analysis the article improves and builds up a specific classification of financial analysis of enterprise activity and offers classification by the following features: objects, subjects, goals of study, automation level, time period of the analytical base, scope of study, organisation system, classification features of the subject, spatial belonging, sufficiency, information sources, periodicity, criterial base, method of data selection for analysis and time direction. All types of financial analysis significantly differ with their inherent properties and parameters depending on the goals of financial analysis. The developed specific classification provides subjects of financial analysis of enterprise activity with a possibility to identify a specific type of financial analysis, which would correctly meet the set goals.


    Agnieszka Kisło


    Full Text Available The beginning of the period where the impact of human activity took dangerous size is considered to be 40 years of the nineteenth century. Then the large-scale production of electricity increased production of metallurgical industry and transport development. Significant changes contributed to rapid population growth and urbanization and industrialization processes. Man by intensive exploitation reduces or completely exhausted most natural resources. This has resulted in the availability criterion, which is distinguished by inexhaustible and exhaustible resources. Exhaustible resources may include solar, wind, energy, ocean currents and the energy of the Earth. Exhaustible resources, however, are the elements of nature that as a result of the operation can be completely depleted or destroyed. These resources include: water, soil, plant world, animal world natural resources. The greater the intensity of acquiring human resources, the faster will be the depleted. There is also a very important division of exhaustible resources: non-renewable resources, renewable and very difficult reproducible (living areas. Non-renewable resources are mainly minerals, such as iron ore, crude oil, coal, sulfur, natural gas, useful stones, limestone, salt, and many other minerals. After extraction resources are processed, and the bed from which they were extracted can no longer be used. It is different from renewable resources; they are characterized by the fact that over time they are reconstituted, although, for this to happen balance of the environment through the rational use must be maintained. These resources include, among others, soil, water, flora and fauna, as well as atmospheric air.

  13. An Analysis of Euphemism from the Perspective of the Politeness Principle%从礼貌原则的角度分析委婉语



    Euphemism is a linguistic phenomenon with cultural social sig-nificance. It is a lubricant which oils the interpersonal relationship and avoids hurting the feeling of others. The Politeness Principle is an important issue in pragmatics. The basic maxims included in this principle are represented in the different uses of euphemism. This paper elaborates on the application of eu-phemism from the perspective of the Politeness Principle.

  14. Relevance of a Particularly Sensitive Sea Area to the Bering Strait Region: a Policy Analysis Using Resilience-Based Governance Principles

    Kevin Hillmer-Pegram


    Full Text Available The Bering Strait, separating the North American and Asian continents, is a productive social-ecological marine system that is vulnerable to increasing maritime traffic. In other parts of the world, the International Maritime Organization (IMO, an agency of the United Nations, has designated similar marine systems as a Particularly Sensitive Sea Area (PSSA in an effort to protect vulnerable resources from international shipping. We present information about the 14 existing PSSAs around the world and the political process by which designation is achieved. We examine specific characteristics of the Bering Strait system that are relevant to a PSSA application; these include vulnerable resources such as marine mammals and their contribution to the food and cultural security of indigenous communities, threats to these resources from shipping activities, and the viable mitigation options to reduce these threats. We then use five criteria derived from empirical research on resilience-based governance to analyze whether a PSSA designation would promote the resilience of marine mammal populations and indigenous communities to increased maritime activities. Despite the elusiveness of a definitive answer, we conclude that although the designation is not a perfect fit from a theoretical standpoint, it still holds the potential to benefit marine mammals and indigenous communities in terms of resilience. We conclude by identifying critical challenges and trade-offs that practitioners would need to negotiate when attempting to apply theoretical governance principles via real-world policy tools.

  15. Neutron Activation Analysis of Inhomogeneous Large Samples; An Explorative Study

    Baas, H.W.


    Neutron activation analysis is a powerful technique for the determination of trace-element concentrations. Since both neutrons that are used for activation and gamma rays that are detected have a high penetrating power, the technique can be applied for relatively large samples (up to 13 L), as demon

  16. Activation and Dose Rate Analysis of 316 Stainless Steel

    XU; Zhi-long; SUN; Zheng; LIU; Xing-min; WAN; Hai-xia


    <正>In order to conduct research on 316 stainless steel to be used in reactors, neutron activation during irradiation and dose rate after irradiation in China Experiment Fast Reactor (CEFR) are calculated and analyzed. Based on 1 g of 316 stainless steel specimen, analysis on the activity of 316 stainless steel irradiated

  17. Performance analysis of active schedules in identical parallel machine

    Changjun WANG; Yugeng XI


    Active schedule is one of the most basic and popular concepts in production scheduling research. For identical parallel machine scheduling with jobs' dynamic arrivals, the tight performance bounds of active schedules under the measurement of four popular objectives are respectively given in this paper. Similar analysis method and conclusions can be generalized to static identical parallel machine and single machine scheduling problem.

  18. Analysis of Activity Patterns and Performance in Polio Survivors


    subjective estimate of their activity level over the past week using the Physical Activity Scale for the Elderly (PASE).3 This instrument dealt with...May 2004. Talaty M. Models for Gait Analysis. 5th SIAMOC (Societa Italiana Di Analisi Del Movimento in Clinica) Congress, Loano, Italy November

  19. Project-Based Language Learning: An Activity Theory Analysis

    Gibbes, Marina; Carson, Lorna


    This paper reports on an investigation of project-based language learning (PBLL) in a university language programme. Learner reflections of project work were analysed through Activity Theory, where tool-mediated activity is understood as the central unit of analysis for human interaction. Data were categorised according to the components of human…

  20. Applying an Activity System to Online Collaborative Group Work Analysis

    Choi, Hyungshin; Kang, Myunghee


    This study determines whether an activity system provides a systematic framework to analyse collaborative group work. Using an activity system as a unit of analysis, the research examined learner behaviours, conflicting factors and facilitating factors while students engaged in collaborative work via asynchronous computer-mediated communication.…

  1. Ethical principles and legal requirements for pediatric research in the EU: an analysis of the European normative and legal framework surrounding pediatric clinical trials.

    Pinxten, Wim; Dierickx, Kris; Nys, Herman


    The involvement of minors in clinical research is inevitable to catch up with the lack of drugs labeled for pediatric use. To encourage the responsible conduct of pediatric clinical trials in the EU, an extensive legal framework has been developed over the past decade in which the practical, ethical, legal, social, and commercial issues in pediatric research are addressed. In this article, the European legal framework surrounding pediatric clinical trials is analyzed from the perspective of the major ethical concerns in pediatric research. The four principles of biomedical ethics will be used as a conceptual framework (1) to map the ethical issues addressed in the European legal framework, (2) to study how these issues are commonly handled in competent adults, (3) to detect workability problems of these paradigmatic approaches in the specific setting of pediatric research, and (4) to illustrate the strong urge to differentiate, specify, or adjust these paradigmatic approaches to guarantee their successful operation in pediatric research. In addition, a concise comparative analysis of the European regulation will be made. To conclude our analysis, we integrate our findings in the existing ethical discussions on issues specific to pediatric clinical research.

  2. Multimodal Teaching Principles on the Basis of Pearson Correlation Analysis%多模态教学原则Pearson相关分析



    Based on the latest research in the fields of multi-modality and multimodality teaching, this study tries to put for-ward the teaching principles on the basis of multimodality teach-ing. During the empirical study, a large number of non-English majors were divided into the contrastive class and the experi-mental class. By analysis of the results of the questionnaire and the Person Correlation Analysis of the pre-test, the mid-test and the post-test, the writer has come to the conclusion that a more harmonious multimodality platform could be constructed so that learning quality and environment could be improved as well.%本研究以多模态、多模态教学领域最新理论为基础,提出多模态教学遵循的原则.通过实证研究,某高校非英语专业学生被分为实验组和对照组,参与多模态教学原则实施过程.通过因子与Pearson 相关分析,可搭建多模态和谐平台,营造有利于提高学习积极性的学习环境.

  3. Seismic tomography analysis using finite differential calculation of the eikonal equation and reciplocal principle; Eikonal equation no sabunkaiho to sohan genri wo riyoshita danseiha tomography kaiseki

    Fujimoto, M.; Ashida, Y.; Watanabe, T.; Sassa, K. [Kyoto University, Kyoto (Japan)


    This paper describes the seismic tomography analysis of underground structures using finite differential calculation (FDC) and a reciprocal principle which points out that a propagation path is constant even if a source and receiver are exchanged with each other. Tomography analysis generally determines a ray length across each underground cell structure by ray tracing method to modify each cell slowness (inverse of velocity). Travel time field was determined by FDC of eikonal equation among ray tracing methods, and a wave propagation path was determined by reciprocity of elastic wave to carry out inversion. In conventional methods, since a wave length is assumed to be infinitesimal by ray theory, false modified slowness structures frequently appears depending on the density of a ray. Wave propagates in a certain width, and is affected by environment. The slowness was thus modified on the basis of the wave propagation path with a certain width by using not ray-tracing but reciprocity. By this modification, false structures were hardly found under a fine grid, and several propagation paths could be considered. 6 refs., 9 figs.

  4. The Principles and Concepts of Geometric Analysis%几何分析中的基本概念与原理



    The present article is based on a talk that I gave at the Chinese Academy of Sciencesin Beijing on October 9, 2001, on the occasion of the inaugration of the Partner Group on GeometricAnalysis for the Max Plank Institute for Mathematics in the Sciences in Leipzig at the CAS. It aims atproviding a perspective on the present state and future research lines of geometric analysis through asurvey of the basic principles and concepts. These are based on ideas from both Riemannian geometryand quantum field theory, and in many cases, they lead to variational problems for minimizing aphysical action or optimizing a geometric quantity.%本文是根据作者在中国科学院"中德几何分析伙伴小组"成立仪式上的演讲整理而成.主要目的在于通过回顾几何分析中的基本概念及基本定理,了解现阶段的研究情况和将来的研究线路.主要描述黎曼几何与量子场论中的思想,特别特别是极化物理量与几何量产生的变分问题.

  5. Applied research of environmental monitoring using instrumental neutron activation analysis

    Chung, Young Sam; Moon, Jong Hwa; Chung, Young Ju


    This technical report is written as a guide book for applied research of environmental monitoring using Instrumental Neutron Activation Analysis. The contents are as followings; sampling and sample preparation as a airborne particulate matter, analytical methodologies, data evaluation and interpretation, basic statistical methods of data analysis applied in environmental pollution studies. (author). 23 refs., 7 tabs., 9 figs.

  6. New insight into the enhanced visible-light photocatalytic activities of B-, C- and B/C-doped anatase TiO2 by first-principles.

    Yu, Jiaguo; Zhou, Peng; Li, Qin


    The geometry structures, formation energies and electronic properties of the B-, C- and B/C-doped anatase TiO2 were investigated by the density functional theory (DFT) calculations of first-principles. The results indicated that the visible-light absorption and photocatalytic activities of the B-, C- and B/C-doped anatase TiO2 were not only influenced by the energy gaps (Eg) and the distributions of impurity states, but also affected by the locations of Fermi levels (EF) and the energies of the edges of band gaps (Ev for the top of valence bands and Ec for the bottom of conduction bands). However, the above four factors changed with the doped models of TiO2. The impurity states in the band gaps reduced the maximum energy gaps in the band gaps, which is responsible for the absorption of visible light. The Fermi levels at the bottom of conduction bands indicated the existence of Ti(3+) ions, which enhanced the separation rates of photogenerated electrons and holes. Further, the energies of the edges of band gaps, determining the dominant types of oxidants (O2(-), hole, ˙OH) in the photocatalytic degradation, were discussed. Moreover, the stability of the doped TiO2 depended on its growth conditions (O-rich or Ti-rich environment). The O-rich growth condition is beneficial to the substitutional B and C atoms to Ti atoms, while the Ti-rich growth condition is favorable to the other doped TiO2 including the most stable co-doped TiO2 with the interstitial B atom and the substitutional C atom to O atom. In addition, our results also showed that the B/C-doped TiO2 inherited the partial electronic properties of single-doped TiO2, but also exhibited many new electronic properties, implying that the electronic properties of co-doped systems are not a mechanical mixture of those of both single-doped systems.

  7. Structural Analysis Extended with Active Fault Isolation - Methods and Algorithms

    Gelso, Esteban R.; Blanke, Mogens


    on system inputs can considerably enhance fault isolability. This paper investigates this possibility of active fault isolation from a structural point of view. While such extension of the structural analysis approach was suggested earlier, algorithms and case studies were needed to explore this theory....... The paper develops algorithms for investigation of the possibilities of active structural isolation and it offers illustrative examples and a larger case study to explore the properties of active structural isolability ideas....



    Aiming at providing with high-load capability in active vibration control of large-scale rotor system, a new type of active actuator to simultaneously reduce the dangers of low frequency flexural and torsional vibrations is designed. The actuator employs electro-hydraulic system and can provide a high and circumferential load. To initialize new research, the characteristics of various kinds of active actuators to control rotor shaft vibration are briefly introduced. The purpose of this paper is to introduce the preliminary results via presenting the structure, functions and operating principles, in particular, the working process of the electro-hydraulic system of the new actuator which includes a set of high speed electromagnetic valves and a series of sloping cone-shaped openings, and presenting the transmission relationships among the control parameters from control signals into the valves to active load onto shaft. The course of the work is dynamic, and a series of spatial forces and moments are put on the shaft to get an external resultant force to reduce excitations that induce vibration of shafts. By checking states of vibration, the actuator can control the impulse width and the interval of injection time for applying different control force to a vibration shaft in two circumference directions through the regulating action of a set of combination directional control valves. The results from simulating analysis and experiment show evidence of that this design can satisfy the case of active process of decreasing of flexural and torsional vibrations.

  9. SS7E机车辅助变流器的工作原理及常见故障分析%Operation Principle of the Auxiliary Current Transformer of SS7E Electric Locomotives and Common Fault Analysis

    卢亚东; 林立新


    该文简要介绍了SS7E机车辅助变流器的工作原理及常见故障分析,详细阐述了运用TGF11的工作原理、电路分析,论述了如何运用辅助变流器在SS7E机车上的运用,阐明了机车辅助变流器其原理的掌握和常见故障的处理方法.%This paper briefly introduced the SS7E locomotive assistance converter principle of work and the common fault analysis. Elabo-rated in detail utilizes TGF11 the principle of work, the circuit analysis, how elaborated has utilized the assistance converter on SS7E loco-motive utilization. It also describes locomotive assistance converter its principle grasping and the common breakdown processing method.

  10. Cytotoxic activity and phytochemical analysis of Arum palaestinum Boiss

    Mai Mohammed Farid; Sameh Reda Hussein; Lamiaa Fawzy Ibrahim; Mohammed Ali El Desouky; Amr Mohammed Elsayed; Ahmad Ali El Oqlah; Mahmoud Mohammed Saker


    Objective:To evaluate the in vitro cytotoxic activity of the fractionated extract as well as isolated compounds of Arum palaestinum Boiss. (A. palaestinum) (black calla lily), and to identify the volatile components which may be responsible for the potential antitumor activity. Methods: A. palaestinum was collected from its natural habitats and subjected to phytochemical analysis for separation of pure compounds. In vitro cytotoxic activity was investigated against four human carcinoma cell lines Hep2, HeLa, HepG2 and MCF7 for the fractionated extract and isolated compounds. While, the diethyl ether fraction was subjected to GC–MS analysis as it exhibited the most potent cytotoxic effect to evaluate the active constituents responsible for the cytotoxic activities. Results:Four flavonoid compounds were isolated (luteolin, chrysoeriol, isoorientin, isovitexin) from the diethyl ether and ethyl acetate. The extracts and the pure isolated compounds showed a significant high antiproliferative activity against all investigated cell lines. The GC–MS analysis revealed the separation and identification of 15 compounds representing 95.01%of the extract and belonging to different groups of chemical compounds. Conclusions:The present study is considered to be the first report on the cytotoxic activities carried out on different selected fractions and pure compounds of A. palaestinum to provide evidences for its strong antitumor activities. In addition, chrysoeriol and isovitexin compounds were isolated for the first time from the studied taxa.

  11. Cytotoxic activity and phytochemical analysis of Arum palaestinum Boiss.

    Mai; Mohammed; Farid; Sameh; Reda; Hussein; Lamiaa; Fawzy; Ibrahim; Mohammed; Ali; El; Desouky; Amr; Mohammed; Elsayed; Ahmad; Ali; El; Oqlah; Mahmoud; Mohammed; Saker


    Objective: To evaluate the in vitro cytotoxic activity of the fractionated extract as well as isolated compounds of Arum palaestinum Boiss.(A. palaestinum)(black calla lily), and to identify the volatile components which may be responsible for the potential antitumor activity.Methods: A. palaestinum was collected from its natural habitats and subjected to phytochemical analysis for separation of pure compounds. In vitro cytotoxic activity was investigated against four human carcinoma cell lines Hep2, He La, Hep G2 and MCF7 for the fractionated extract and isolated compounds. While, the diethyl ether fraction was subjected to GC–MS analysis as it exhibited the most potent cytotoxic effect to evaluate the active constituents responsible for the cytotoxic activities.Results: Four flavonoid compounds were isolated(luteolin, chrysoeriol, isoorientin,isovitexin) from the diethyl ether and ethyl acetate. The extracts and the pure isolated compounds showed a significant high antiproliferative activity against all investigated cell lines. The GC–MS analysis revealed the separation and identification of 15 compounds representing 95.01% of the extract and belonging to different groups of chemical compounds.Conclusions: The present study is considered to be the first report on the cytotoxic activities carried out on different selected fractions and pure compounds of A. palaestinum to provide evidences for its strong antitumor activities. In addition,chrysoeriol and isovitexin compounds were isolated for the first time from the studied taxa.

  12. Influence of Agathi grandiflora active principles inhibit viral multiplication and stimulate immune system in Indian white shrimp Fenneropenaeus indicus against white spot syndrome virus infection.

    Bindhu, Francis; Velmurugan, Subramanian; Donio, Mariathason Birdilla Selva; Michaelbabu, Mariavincent; Citarasu, Thavasimuthu


    Five herbs including Adathoda vasica, Agathi grandiflora, Leucas aspera, Psoralea corylifolia, and Quercus infectoria were selected to screen the antiviral and immunostimulant activity against white spot syndrome virus (WSSV) and Vibrio harveyi respectively using different organic polar and non-polar solvents. Based on the initial screening results, ethyl acetate and methanolic extracts of A. grandiflora had strong antiviral and immunostimulant activities. Those extracts incubated with WSSV injected Fenneropenaeus indicus got only 20% mortality and no PCR positive signals were seen in two step PCR amplification. The methanolic extracts of A. grandiflora were further purified through silica column chromatography and the fractions screened again for antiviral and immunostimulant activity. The secondary screening results revealed that, the fractions of F5 to F7 had effectively controlled the WSSV multiplication and V. harveyi growth. The pooled fractions (F5 to F7) was structurally characterized by gas chromatograph-mass spectrometry (GC-MS) analysis and few compounds were identified including 3,7.11,15-Tetramethyl-2-Hexane-1-ol, pytol and 1,2-Benzenedicarboxylic acid, diisooctyl ester. The pooled fractions were mixed with the basal feed ingredients at the concentration of 100 (D-1), 200 (D-2), 300 (D-3) and 400 (D-4) mg kg(-1) and the diets fed to the F. indicus (9.0 ± 0.5 g) for 30 days. After the completion of feeding trail, they were challenged with virulent WSSV and studied the cumulative mortality, molecular diagnosis by quantitative real time PCR (qRT-PCR), biochemical, haematological and immunological parameters. The control diet fed F. indicus succumbed to death 100% within 3 days whereas the D-3 and D-4 helped to reduced the cumulative mortality of 60-80% respectively. The qRT-PCR revealed that, the WSSV copy number was gradually decreased when increasing concentration of A. grandiflora extract active fraction in the diets. The diets D-3 and D-4 helped to

  13. Phytochemical analysis and free radical scavenging activity of medicinal plants Gnidia glauca and Dioscorea bulbifera.

    Ghosh, Sougata; Derle, Abhishek; Ahire, Mehul; More, Piyush; Jagtap, Soham; Phadatare, Suvarna D; Patil, Ajay B; Jabgunde, Amit M; Sharma, Geeta K; Shinde, Vaishali S; Pardesi, Karishma; Dhavale, Dilip D; Chopade, Balu A


    Gnidia glauca and Dioscorea bulbifera are traditional medicinal plants that can be considered as sources of natural antioxidants. Herein we report the phytochemical analysis and free radical scavenging activity of their sequential extracts. Phenolic and flavonoid content were determined. Scavenging activity was checked against pulse radiolysis generated ABTS(•+) and OH radical, in addition to DPPH, superoxide and hydroxyl radicals by biochemical methods followed by principal component analysis. G. glauca leaf extracts were rich in phenolic and flavonoid content. Ethyl acetate extract of D. bulbifera bulbs and methanol extract of G. glauca stem exhibited excellent scavenging of pulse radiolysis generated ABTS(•+) radical with a second order rate constant of 2.33 × 10(6) and 1.72 × 10(6), respectively. Similarly, methanol extract of G. glauca flower and ethyl acetate extract of D. bulbifera bulb with second order rate constants of 4.48 × 10(6) and 4.46 × 10(6) were found to be potent scavengers of pulse radiolysis generated OH radical. G. glauca leaf and stem showed excellent reducing activity and free radical scavenging activity. HPTLC fingerprinting, carried out in mobile phase, chloroform: toluene: ethanol (4: 4: 1, v/v) showed presence of florescent compound at 366 nm as well as UV active compound at 254 nm. GC-TOF-MS analysis revealed the predominance of diphenyl sulfone as major compound in G. glauca. Significant levels of n-hexadecanoic acid and octadecanoic acid were also present. Diosgenin (C₂₇H₄₂O₃) and diosgenin (3á,25R) acetate were present as major phytoconstituents in the extracts of D. bulbifera. G. glauca and D. bulbifera contain significant amounts of phytochemicals with antioxidative properties that can be exploited as a potential source for herbal remedy for oxidative stress induced diseases. These results rationalize further investigation in the potential discovery of new natural bioactive principles from these two important

  14. Heisenberg's uncertainty principle

    Busch, Paul; Heinonen, Teiko; Lahti, Pekka


    Heisenberg's uncertainty principle is usually taken to express a limitation of operational possibilities imposed by quantum mechanics. Here we demonstrate that the full content of this principle also includes its positive role as a condition ensuring that mutually exclusive experimental options can be reconciled if an appropriate trade-off is accepted. The uncertainty principle is shown to appear in three manifestations, in the form of uncertainty relations: for the widths of the position and...

  15. Biomechanics principles and practices

    Peterson, Donald R


    Presents Current Principles and ApplicationsBiomedical engineering is considered to be the most expansive of all the engineering sciences. Its function involves the direct combination of core engineering sciences as well as knowledge of nonengineering disciplines such as biology and medicine. Drawing on material from the biomechanics section of The Biomedical Engineering Handbook, Fourth Edition and utilizing the expert knowledge of respected published scientists in the application and research of biomechanics, Biomechanics: Principles and Practices discusses the latest principles and applicat

  16. Fusion research principles

    Dolan, Thomas James


    Fusion Research, Volume I: Principles provides a general description of the methods and problems of fusion research. The book contains three main parts: Principles, Experiments, and Technology. The Principles part describes the conditions necessary for a fusion reaction, as well as the fundamentals of plasma confinement, heating, and diagnostics. The Experiments part details about forty plasma confinement schemes and experiments. The last part explores various engineering problems associated with reactor design, vacuum and magnet systems, materials, plasma purity, fueling, blankets, neutronics

  17. Powerful flaring configurations in solar active regions: magnetic topology via special features of delta-structure phenomenon. I. Basic principles of topological model

    Ikhsanov, R N; Marushin, Yu.V.


    The close connection of magnetic field structure on the one hand and observable features of complex ARs with high flare efficiency on the other one is investigated in frames of so-called dynamic classification of flaring magnetic configurations (FMC) and the simple topological model of interacting magnetic complexes (IMC) suggested by Ikhsanov (1982). The primary objective of the present work is to expose general statements of the specified model and classification, the secondary one assumes the critical analysis and logical generalization of several important regularities being frequently observable in evolution stages of a typical complex AR with powerful flares including proton ones. Those cases are basically examined where the development of photospheric situation was marked by the formation of delta-configuration phenomenon described by Kunzel (1960) as one of the most impressive precursors of high flare activity. Without trying to use any additional assumptions and alternative hypotheses, the qualitativ...

  18. Solving the confusion of gnaphaliin structure: gnaphaliin A and gnaphaliin B identified as active principles of Gnaphalium liebmannii with tracheal smooth muscle relaxant properties.

    Rodríguez-Ramos, Fernando; Navarrete, Andrés


    Inflorescences of Gnaphalium liebmannii, commonly known as "Gordolobo", is the most important remedy in Mexican traditional medicine to treat respiratory diseases, including asthma. By a bioguided fractionation of the n-hexane extract of this plant, following the relaxant effect on guinea pig tracheal smooth muscle, the flavones 5,7-dihydroxy-3,8-dimethoxyflavone (1) and 3,5-dihydroxy-7,8-dimethoxyflavone (2) were identified as the active relaxant compounds. Compounds 1 and 2 showed more potent relaxant properties than aminophylline in this model. Both 1 and 2 have been described as gnaphaliin in the past; here EIMS data, NMR experiments for both compounds, and X-ray diffraction analysis for 1 provided structural information to suggest that 1 and 2 should be named gnaphaliins A and B, respectively.

  19. Database principles programming performance

    O'Neil, Patrick


    Database: Principles Programming Performance provides an introduction to the fundamental principles of database systems. This book focuses on database programming and the relationships between principles, programming, and performance.Organized into 10 chapters, this book begins with an overview of database design principles and presents a comprehensive introduction to the concepts used by a DBA. This text then provides grounding in many abstract concepts of the relational model. Other chapters introduce SQL, describing its capabilities and covering the statements and functions of the programmi

  20. Behavioral activation treatments of depression: a meta-analysis.

    Cuijpers, Pim; van Straten, Annemieke; Warmerdam, Lisanne


    Activity scheduling is a behavioral treatment of depression in which patients learn to monitor their mood and daily activities, and how to increase the number of pleasant activities and to increase positive interactions with their environment. We conducted a meta-analysis of randomized effect studies of activity scheduling. Sixteen studies with 780 subjects were included. The pooled effect size indicating the difference between intervention and control conditions at post-test was 0.87 (95% CI: 0.60 - 1.15). This is a large effect. Heterogeneity was low in all analyses. The comparisons with other psychological treatments at post-test resulted in a non-significant pooled effect size of 0.13 in favor of activity scheduling. In ten studies activity scheduling was compared to cognitive therapy, and the pooled effect size indicating the difference between these two types of treatment was 0.02. The changes from post-test to follow-up for activity scheduling were non-significant, indicating that the benefits of the treatments were retained at follow-up. The differences between activity scheduling and cognitive therapy at follow-up were also non-significant. Activity scheduling is an attractive treatment for depression, not only because it is relatively uncomplicated, time-efficient and does not require complex skills from patients or therapist, but also because this meta-analysis found clear indications that it is effective.

  1. Individual and combined toxic effect of nickel and chromium on biochemical constituents in E. coli using FTIR spectroscopy and Principle component analysis.

    Gupta, Annika Durve; Karthikeyan, Sivakumaran


    Ni and Cr are ubiquitous pollutants in the aquatic environments. These heavy metals elicit toxicities to aquatic organisms including microbes. In this study, interaction of the two heavy metals on the toxicity in Escherichia coli (E. coli) was studied using FTIR spectroscopy. The binding of Ni(II) to E. coli was stronger than that for Cr(VI). Cr exhibited antagonistic effects in the presence of Ni in E. coli. FTIR analysis showed a decrease in lipid content in the presence of Ni and not for Cr. Further, a decrease in band area was observed in the region of 3000-2800cm(-1) and at ~1455cm(-1) due to a decrease in fatty acids and lipid molecules. The band area ratio of lipid was used to monitor the changes in fatty acids due to metal toxicity. Principle component method helps to discriminates the results between control and metal toxicities in E. coli from the FTIR data. The study shows the importance of metal interaction and its toxicity on E. coli.

  2. The utilization of Depth Invariant Index and Principle Component Analysis for mapping seagrass ecosystem of Kotok Island and Karang Bongkok, Indonesia

    Manuputty, Agnestesya; Lumban Gaol, Jonson; Bahri Agus, Syamsul; Wayan Nurjaya, I.


    Seagrass perform a variety of functions within ecosystems, and have both economic and ecological values, therefore it has to be kept sustainable. One of the stages to preserve seagrass ecosystems is monitoring by utilizing thespatial data accurately. The purpose of the study was to assess and compare the accuracy of DII and PCA transformationsfor mapping of seagrass ecosystems. Fieldstudy was carried out in Karang Bongkok and Kotok Island waters, in Agustus 2014 and in March 2015. A WorldView-2 image acquisition date of 5 October 2013 was used in the study. The transformations for image processing data were Depth Invariant Index (DII) and Principle Component Analysis (PCA) using Support Vector Machine (SVM) classification. The result shows that benthic habitat mapping of Karang Bongkok using DII and PCA transformations were 72%and 81% overall’s accuracy respectively, whereas of Kotok Island were 83% and 84% overall’s accuracy respectively. There were seven benthic habitat types found in karang Bongkok waters and in Kotok Island namely seagrass, sand, rubble, coral, logoon, sand mix seagrass, and sand mix rubble. PCA transformation was effectively to improve mapping accuracy of sea grass mapping in Kotok Island and Karang Bongkok.

  3. First-principles mode-by-mode analysis for electron-phonon scattering channels and mean free path spectra in GaAs

    Liu, Te-Huan; Zhou, Jiawei; Liao, Bolin; Singh, David J.; Chen, Gang


    We present a first-principles framework to investigate the electron scattering channels and transport properties for polar materials by combining the exact solution of the linearized electron-phonon (e-ph) Boltzmann transport equation in its integral-differential form associated with the e-ph coupling matrices obtained from the polar Wannier interpolation scheme. No ad hoc parameter is required throughout this calculation, and GaAs, a well-studied polar material, is used as an example to demonstrate this method. In this work, the long-range and short-range contributions as well as the intravalley and intervalley transitions in the e-ph interactions (EPIs) have been quantitatively addressed. Promoted by such mode-by-mode analysis, we find that in GaAs, the piezoelectric scattering is comparable to deformation-potential scattering for electron scatterings by acoustic phonons in EPI even at room temperature, and it makes a significant contribution to mobility. Furthermore, we achieved good agreement with experimental data for the mobility, and we identified that electrons with mean free paths between 130 and 210 nm provide the dominant contribution to the electron transport at 300 K. Such information provides a deeper understanding of the electron transport in GaAs, and the presented framework can be readily applied to other polar materials.

  4. Uncertainty Analysis Principles and Methods


    122-07, September 2007 ⎟ ⎠ ⎞ ⎜ ⎝ ⎛ +Φ= − 2 11 n n PL (2-13) where nPn 2/11−= . Any points that lie outside x ±Lnsn are rejected. 2.2.7...sensor is a transistor , the number of junctions is 2. 3.1.35 Operator Bias. Error due to the perception or influence of a human operator or other

  5. A grid for a precise analysis of daily activities.

    Wojtasik, V; Olivier, C; Lekeu, F; Quittre, A; Adam, S; Salmon, E


    Assessment of daily living activities is essential in patients with Alzheimer's disease. Most current tools quantitatively assess overall ability but provide little qualitative information on individual difficulties. Only a few tools allow therapists to evaluate stereotyped activities and record different types of errors. We capitalised on the Kitchen Activity Assessment to design a widely applicable analysis grid that provides both qualitative and quantitative data on activity performance. A cooking activity was videotaped in 15 patients with dementia and assessed according to the different steps in the execution of the task. The evaluations obtained with our grid showed good correlations between raters, between versions of the grid and between sessions. Moreover, the degree of independence obtained with our analysis of the task correlated with the Kitchen Activity Assessment score and with a global score of cognitive functioning. We conclude that assessment of a daily living activity with this analysis grid is reproducible and relatively independent of the therapist, and thus provides quantitative and qualitative information useful for both evaluating and caring for demented patients.

  6. Studies on anti-inflammatory activity of spice principles and dietary n-3 polyunsaturated fatty acids on carrageenan-induced inflammation in rats.

    Reddy, A C; Lokesh, B R


    The antioxidant spice principles curcumin and eugenol when given by gavage lowered the carrageenan-induced edema in the foot pads of rats. This lowering effect was dependent on the concentration, the time gap between the administration of spice principles and the induction of inflammation by carrageenan. Dietary lipids also influenced the extent of inflammation. Animals fed 10% cod liver oil [containing n-3 polyunsaturated fatty acids (PUFA)] for 10 weeks showed a significantly lower inflammation compared to that observed in animals fed diets supplemented with 10% groundnut oil (rich in n-6 PUFA) or 10% coconut oil (rich in medium-chain saturated fatty acids). Supplementation of diets with 1 weight% of curcumin did not affect the inflammatory responses of animals to carrageenan injection. However, supplementation of diets with 0.17 weight% eugenol further lowered inflammation by 16, 32 and 30% in animals fed coconut oil, groundnut oil and cod liver oil, respectively. Therefore, combinations of dietary lipids with spice principles like eugenol can help in lowering inflammation.

  7. A package for gamma-ray spectrum analysis and routine neutron activation analysis

    M E Medhat; A Abdel-Hafiez; Z Awaad; M A Ali


    A package for gamma spectrum analysis (PGSA) was developed using object oriented Borland C++ design for MS-windows. This package consists of five programs which can be used for gamma-ray spectrum analysis and routine neutron activation analysis. The advantages of PGSA are its simple algorithms and its need for only minimum amount of input information.

  8. Analysis of nuclear activity of ten polar ring galaxies

    Freitas-Lemes, P; Dors, O L; Faúndez-Abans, M


    The accumulation of mass from the interaction process that forms the polar ring galaxies is a factor that favors the conditions necessary to trigger nonthermal nuclear activities.. This fact encouraged the chemical analysis of ten polar ring galaxies. In order to verify the presence of an active nucleus in these galaxias, we built diagnostic diagrams using lines H{\\beta}, [OIII], [HI], H{\\alpha}, [NII], and [SII] and classified the type of nuclear activity. For galaxies that do not show shock, the parameters N2 and O3N2 were also determined. From this sample, we identified seven galaxies with an active nucleus and three that behave as HII regions. One galaxy with an active nucleus was classified as Seyfert. Although our data do not provide a statistically significant sample, we can speculate that polar ring galaxies are a setting conducive to trigger non-thermal nuclear activities.

  9. An Analysis of Creative Process Learning in Computer Game Activities Through Player Experiences

    Wilawan Inchamnan


    Full Text Available This research investigates the extent to which creative processes can be fostered through computer gaming. It focuses on creative components in games that have been specifically designed for educational purposes: Digital Game Based Learning (DGBL. A behavior analysis for measuring the creative potential of computer game activities and learning outcomes is described. Creative components were measured by examining task motivation and domain-relevant and creativity-relevant skill factors. The research approach applied heuristic checklists in the field of gameplay to analyze the stage of player activities involved in the performance of the task and to examine player experiences with the Player Experience of Need Satisfaction (PENS survey. Player experiences were influenced by competency, autonomy, intuitive controls, relatedness and presence. This study examines the impact of these activities on the player experience for evaluating learning outcomes through school records. The study is designed to better understand the creative potential of people who are engaged in learning knowledge and skills during the course while playing video games. The findings show the creative potential that occurred to yield levels of creative performance within game play activities to support learning. The anticipated outcome is knowledge on how video games foster creative thinking as an overview of the Creative Potential of Learning Model (CPLN. CPLN clearly describes the interrelationships between principles of learning and creative potential, the interpretation of the results is indispensable.


    D.A. Kalinich


    Impacts due to nearby installations and operations were determined in the Preliminary MGDS Hazards Analysis (CRWMS M&O 1996) to be potentially applicable to the proposed repository at Yucca Mountain. This determination was conservatively based on limited knowledge of the potential activities ongoing on or off the Nevada Test Site (NTS). It is intended that the Industrial/Military Activity-Initiated Accident Screening Analysis provided herein will meet the requirements of the ''Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants'' (NRC 1987) in establishing whether this external event can be screened from further consideration or must be included as a design basis event (DBE) in the development of accident scenarios for the Monitored Geologic Repository (MGR). This analysis only considers issues related to preclosure radiological safety. Issues important to waste isolation as related to impact from nearby installations will be covered in the MGR performance assessment.

  11. Visual Analysis of Biological Activity Data with Scaffold Hunter.

    Klein, Karsten; Koch, Oliver; Kriege, Nils; Mutzel, Petra; Schäfer, Till


    The growing interest in chemogenomics approaches over the last years has led to an increasing amount of data regarding chemical and the corresponding biological activity space. The resulting data, collected in either in-house or public databases, need to be analyzed efficiently to speed-up the increasingly difficult task of drug discovery. Unfortunately, the discovery of new chemical entities or new targets for known drugs ('drug repurposing') is not suitable to a fully automated analysis or a simple drill down process. Visual interactive interfaces that allow to explore chemical space in a systematic manner and facilitate analytical reasoning can help to overcome these problems. Scaffold Hunter is a tool for the visual analysis of chemical compound databases that provides integrated visualization and analysis of biological activity data and fosters the interactive exploration of data imported from a variety of sources. We describe the features and illustrate the use by means of an exemplary analysis workflow.

  12. Inference of splicing regulatory activities by sequence neighborhood analysis.

    Michael B Stadler


    Full Text Available Sequence-specific recognition of nucleic-acid motifs is critical to many cellular processes. We have developed a new and general method called Neighborhood Inference (NI that predicts sequences with activity in regulating a biochemical process based on the local density of known sites in sequence space. Applied to the problem of RNA splicing regulation, NI was used to predict hundreds of new exonic splicing enhancer (ESE and silencer (ESS hexanucleotides from known human ESEs and ESSs. These predictions were supported by cross-validation analysis, by analysis of published splicing regulatory activity data, by sequence-conservation analysis, and by measurement of the splicing regulatory activity of 24 novel predicted ESEs, ESSs, and neutral sequences using an in vivo splicing reporter assay. These results demonstrate the ability of NI to accurately predict splicing regulatory activity and show that the scope of exonic splicing regulatory elements is substantially larger than previously anticipated. Analysis of orthologous exons in four mammals showed that the NI score of ESEs, a measure of function, is much more highly conserved above background than ESE primary sequence. This observation indicates a high degree of selection for ESE activity in mammalian exons, with surprisingly frequent interchangeability between ESE sequences.

  13. Classroom Demonstrations of Social Psychological Principles

    Singleton, Royce Jr.


    Describes eight classroom activities which instruct college level sociology students about major concepts and principles of social psychology. Concepts include gestalt psychology, nonverbal communication, adaptation level, relative deprivation, selective exposure, labeling, sexism, and perceptual distortion. (Author/DB)

  14. Great Principles of Computing

    Denning, Peter J.


    The Great Principles of Computing is a framework for understanding computing as a field of science. The website ...April 2008 (Rev. 8/31/08) The Great Principles of Computing is a framework for understanding computing as a field of science.

  15. Basic principle of superconductivity

    De Cao, Tian


    The basic principle of superconductivity is suggested in this paper. There have been two vital wrong suggestions on the basic principle, one is the relation between superconductivity and the Bose-Einstein condensation (BEC), and another is the relation between superconductivity and pseudogap.

  16. Phytochemical analysis and antagonistic activity of Ixora macrothyrsa on multidrug resistant bacteria

    Femina Wahab; Kalidass Subramaniam; Sembian Suriyamoorthy; Sweetin Preethi Subburaj


    Objective: The present investigation was an attempt to identify the potent drug principles ofIxora macrothyrsa flower against Methicillin Resistant Staphylococcus aureus and Acinetobacter baumannii. Methods: Hot extraction soxhlet method was performed for the extraction of Ixora macrothyrsa flower powder with different solvents. Antagonistic activity checked for all extracts with MTCC standard pathogenic strains and multiple drug resistant strains. Followed this minimal inhibitory concentration, phenol estimation, High performance thin layer chromatography analysis and Gas chromatography- mass spectrometry analysis were performed for Ixora macrothyrsa ethanolic extract. Results: The results from the present study indicate that the flowers of the plant has rich source of phytochemicals in ethanol extracts compare to acetone and methanol extracts. The quantitative estimation of ethanolic extracts of Ixora macrothyrsa showed phenol content 83.67±.04 μg/g of ascorbic acid equivalent. The ethanol extract exhibited good antibacterial activity against all tested pathogens. In this study we point out that ethanol and methanol extracts showed supreme activity against Methicillin Resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii. The MIC of Ixora macrothyrsa ethanolic extract was identified as 22μg/ml for MRSA and 200μg/ml for Acinetobacter baumannii. The HPTLC analysis of the ethanol plant extract inferred that it contain both polyphenol and terpenoids. In GC-MS analysis the major constituent was identified as Ethene (2-chloroethoxy)-, 1-propanol 2-chloro, urethane with 16.39 area %. Conclusions: Hence it is inferred from our study that the plant flower would be a promising source of phytomedicine against multidrug resistant strains MRSA and Acinetobacter baumannii.

  17. Basic Concepts and Principles of Marketing.

    Beder, Hal


    Presents an overview of marketing concepts and principles. These include (1) organizational objectives, (2) exchange, (3) value, (4) market segmentation, (5) market position, (6) consumer analysis, (7) product, (8) promotion, (9) place, and (10) price. (CH)

  18. Equivalence principles exotica



    This is a short review of the different prin-ciples of equivalence stated and used in the context of the gravitational interaction. We emphasize the need for precision in stating and differentiating these different equivalence principles, especially in the context of preva-lent confusion regarding the applicability of the weak equivalence principle in quantum mechanics. We discuss several empirical results pertaining to the validity of the equivalence principle in exotic physical sitautions not di-rectly amenable to experimental tests. We conclude with a section on the physical basis of the universal validity of the equivalence principle, as manifest in the universality of free fall, and discuss its link to cosmic gravity.

  19. Dynamic sealing principles

    Zuk, J.


    The fundamental principles governing dynamic sealing operation are discussed. Different seals are described in terms of these principles. Despite the large variety of detailed construction, there appear to be some basic principles, or combinations of basic principles, by which all seals function, these are presented and discussed. Theoretical and practical considerations in the application of these principles are discussed. Advantages, disadvantages, limitations, and application examples of various conventional and special seals are presented. Fundamental equations governing liquid and gas flows in thin film seals, which enable leakage calculations to be made, are also presented. Concept of flow functions, application of Reynolds lubrication equation, and nonlubrication equation flow, friction and wear; and seal lubrication regimes are explained.

  20. Variational principles in physics

    Basdevant, Jean-Louis


    Optimization under constraints is an essential part of everyday life. Indeed, we routinely solve problems by striking a balance between contradictory interests, individual desires and material contingencies. This notion of equilibrium was dear to thinkers of the enlightenment, as illustrated by Montesquieu’s famous formulation: "In all magistracies, the greatness of the power must be compensated by the brevity of the duration." Astonishingly, natural laws are guided by a similar principle. Variational principles have proven to be surprisingly fertile. For example, Fermat used variational methods to demonstrate that light follows the fastest route from one point to another, an idea which came to be known as Fermat’s principle, a cornerstone of geometrical optics. Variational Principles in Physics explains variational principles and charts their use throughout modern physics. The heart of the book is devoted to the analytical mechanics of Lagrange and Hamilton, the basic tools of any physicist. Prof. Basdev...

  1. Principles of European Company Law

    Werlauff, Erik


    The article focuses on how much we have in common in Europe within company law and its development, and on the principles which are the determining factors for the activities of European companies. The article shows that what we have in common greatly outweighs what divides us......, and this is presented in the article as the provisional capstone of 400 years of joint European development of company law....

  2. Geolocation Techniques Principles and Applications

    Gentile, Camillo; Raulefs, Ronald; Teolis, Carole


    Geolocation Techniques: Principles and Applications provides a comprehensive overview of geolocation technologies and techniques, from radio-frequency based to inertial based. The focus of this book is to provide an overview on the different types of infra-structure supported by most commercial localization systems as well as on the most popular computational techniques which these systems employ. This book can serve as a reference for scholarly activities such as teaching, self-learning, or research.


    M. A. Nosov


    Full Text Available Experimental autoimmune encephalomyelitis in an adoptive transfer model is caused by injecting animal with activated T cells specific for a CNS antigen, e.g., basic myelin protein. Development of autimmune inflammation in such a model is connected with changed functional stateof encephalytogenic (EG T cells in the coure of disease progression, as reflected by changes in their activation, proliferation and motility levels. Present work describes an original technique allowing for in vitro analysis of encephalytogenic T cell motility, and studying effects of certain compomemts of extracellular matrix upon migration and functional activities of EG T cells.

  4. Cluster analysis of activity-time series in motor learning

    Balslev, Daniela; Nielsen, Finn Å; Futiger, Sally A;


    Neuroimaging studies of learning focus on brain areas where the activity changes as a function of time. To circumvent the difficult problem of model selection, we used a data-driven analytic tool, cluster analysis, which extracts representative temporal and spatial patterns from the voxel...... practice-related activity in a fronto-parieto-cerebellar network, in agreement with previous studies of motor learning. These voxels were separated from a group of voxels showing an unspecific time-effect and another group of voxels, whose activation was an artifact from smoothing...

  5. Cluster analysis of activity-time series in motor learning

    Balslev, Daniela; Nielsen, Finn Årup; Frutiger, Sally A.;


    Neuroimaging studies of learning focus on brain areas where the activity changes as a function of time. To circumvent the difficult problem of model selection, we used a data-driven analytic tool, cluster analysis, which extracts representative temporal and spatial patterns from the voxel...... practice-related activity in a fronto-parieto-cerebellar network, in agreement with previous studies of motor learning. These voxels were separated from a group of voxels showing an unspecific time-effect and another group of voxels, whose activation was an artifact from smoothing. Hum. Brain Mapping 15...

  6. Graphics and visualization principles & algorithms

    Theoharis, T; Platis, Nikolaos; Patrikalakis, Nicholas M


    Computer and engineering collections strong in applied graphics and analysis of visual data via computer will find Graphics & Visualization: Principles and Algorithms makes an excellent classroom text as well as supplemental reading. It integrates coverage of computer graphics and other visualization topics, from shadow geneeration and particle tracing to spatial subdivision and vector data visualization, and it provides a thorough review of literature from multiple experts, making for a comprehensive review essential to any advanced computer study.-California Bookw

  7. Archimedes' principle for Brownian liquid

    Burdzy, Krzysztof; Chen, Zhen-Qing; Pal, Soumik


    We consider a family of hard core objects moving as independent Brownian motions confined to a vessel by reflection. These are subject to gravitational forces modeled by drifts. The stationary distribution for the process has many interesting implications, including an illustration of the Archimedes’ principle. The analysis rests on constructing reflecting Brownian motion with drift in a general open connected domain and studying its stationary distribution. In dimension two we utilize known ...

  8. Archimedes' principle for Brownian liquid

    Burdzy, Krzysztof; Pal, Soumik


    We consider a family of hard core objects moving as independent Brownian motions confined to a vessel by reflection. These are subject to gravitational forces modeled by drifts. The stationary distribution for the process has many interesting implications, including an illustration of the Archimedes' principle. The analysis rests on constructing reflecting Brownian motion with drift in a general open connected domain and studying its stationary distribution. In dimension two we utilize known results about sphere packing.

  9. Some principles of spatial organization in art.

    Tyler, Christopher W


    Rules of composition in paintings form a rich probe into the principles of perceptual processing that have been discussed for centuries. These principles can be studied by controlled scientific experiments, but an alternative approach is to use the art works themselves as a database for direct analysis. This paper focuses on the analysis of composition in relation to the canvas frame. An underlying principle is the compositional pyramid rising from the bottom of the frame to a center of consciousness high on the midline, which also finds its expression in the configuration of portrait paintings. The analyses presented reveal a dominant positioning principle for one eye in a portrait to lie on the vertical axis with an unbiased accuracy of the order of +/-5%. Analysis of the vertical location shows that the dominant height is at or above the Golden Section level on the vertical axis. In general, the layout of the portrait follows the principle of the compositional pyramid, with a center of consciousness at its apex, but there are many other compositional principles at work in the corpus of portraits in general. Analysis of the portraits of particular artists reveals that special features of their work must be considered in order to identify those that do and do not conform to the eye-centering principle.

  10. Statistical analysis of acoustic wave parameters near active regions

    Soares, M Cristina Rabello; Scherrer, Philip H


    In order to quantify the influence of magnetic fields on acoustic mode parameters and flows in and around active regions, we analyse the differences in the parameters in magnetically quiet regions nearby an active region (which we call `nearby regions'), compared with those of quiet regions at the same disc locations for which there are no neighboring active regions. We also compare the mode parameters in active regions with those in comparably located quiet regions. Our analysis is based on ring diagram analysis of all active regions observed by HMI during almost five years. We find that the frequency at which the mode amplitude changes from attenuation to amplification in the quiet nearby regions is around 4.2 mHz, in contrast to the active regions, for which it is about 5.1 mHz. This amplitude enhancement (the `acoustic halo effect') is as large as that observed in the active regions, and has a very weak dependence on the wave propagation direction. The mode energy difference in nearby regions also changes...

  11. The precautionary principle and regulation of chemicals

    Løkke, Søren

    on conflicting sciences, and a broader analysis of the development of chemicals regulation and the interrelation to the precautionary principle. It is concluded that the precautionary principle in practise requires a vivid debate at all levels including scientific approaches and public deliberation.......This dissertation presents a combined approach to the study of discourse and technology. The approach is applied on two different cases involving the precautionary principle and chemicals; namely an in-depth analysis of a short-lived prohibition against a specific class of pesticides based...

  12. Basic principles of stability.

    Egan, William; Schofield, Timothy


    An understanding of the principles of degradation, as well as the statistical tools for measuring product stability, is essential to management of product quality. Key to this is management of vaccine potency. Vaccine shelf life is best managed through determination of a minimum potency release requirement, which helps assure adequate potency throughout expiry. Use of statistical tools such a least squares regression analysis should be employed to model potency decay. The use of such tools provides incentive to properly design vaccine stability studies, while holding stability measurements to specification presents a disincentive for collecting valuable data. The laws of kinetics such as Arrhenius behavior help practitioners design effective accelerated stability programs, which can be utilized to manage stability after a process change. Design of stability studies should be carefully considered, with an eye to minimizing the variability of the stability parameter. In the case of measuring the degradation rate, testing at the beginning and the end of the study improves the precision of this estimate. Additional design considerations such as bracketing and matrixing improve the efficiency of stability evaluation of vaccines.

  13. 社会资本评价的定位及其原则探究%Analysis on the Evaluation of Social Capital and it's Principles



      Evaluation of social capital refers to the reflection of a subject between itself and the social capital or a subject’s reflections or judgments on the value of social capital . The principle of subjectivity, the scientific principle, the principle of effectiveness and the systematic principle is the basic principles of the evaluation of social capital. The four principles contact between each other, work together and provide a important basis to evaluate social capital.%  社会资本评价是指主体对自身与社会资本之间所形成的效用关系的一种反映或评判,是主体对社会资本价值的反映或评判。主体性原则、科学性原则、实效性原则和系统性原则是评价社会资本的四条基本原则。它们之间彼此联系、共同作用,为正确评价社会资本提供重要依据。

  14. Statistical Analysis of Acoustic Wave Parameters Near Solar Active Regions

    Rabello-Soares, M. Cristina; Bogart, Richard S.; Scherrer, Philip H.


    In order to quantify the influence of magnetic fields on acoustic mode parameters and flows in and around active regions, we analyze the differences in the parameters in magnetically quiet regions nearby an active region (which we call “nearby regions”), compared with those of quiet regions at the same disk locations for which there are no neighboring active regions. We also compare the mode parameters in active regions with those in comparably located quiet regions. Our analysis is based on ring-diagram analysis of all active regions observed by the Helioseismic and Magnetic Imager (HMI) during almost five years. We find that the frequency at which the mode amplitude changes from attenuation to amplification in the quiet nearby regions is around 4.2 mHz, in contrast to the active regions, for which it is about 5.1 mHz. This amplitude enhacement (the “acoustic halo effect”) is as large as that observed in the active regions, and has a very weak dependence on the wave propagation direction. The mode energy difference in nearby regions also changes from a deficit to an excess at around 4.2 mHz, but averages to zero over all modes. The frequency difference in nearby regions increases with increasing frequency until a point at which the frequency shifts turn over sharply, as in active regions. However, this turnover occurs around 4.9 mHz, which is significantly below the acoustic cutoff frequency. Inverting the horizontal flow parameters in the direction of the neigboring active regions, we find flows that are consistent with a model of the thermal energy flow being blocked directly below the active region.

  15. Making Sense of Total VET Activity: An Initial Market Analysis

    National Centre for Vocational Education Research (NCVER), 2016


    Following the successful first national publication of total vocational education and training (VET) activity and presentation of various informative data products, NCVER has continued to undertake further analysis of the submitted data. This paper is the first in a suite of the National Centre for Vocational Education Research (NCVER) authored…

  16. Instrumental neutron activation analysis of some ayurvedic medicines: Pt. 1

    Rajurkar, N.S.; Vinchurkar, M.S. (Poona Univ., Pune (India). Dept. of Chemistry)


    Several medicines have been manufactured and prescribed to overcome mineral deficiencies in the human body. Such medicines are mixtures of several components. The present work is undertaken to analyze various Ayurvedic medicines, mainly of herbal origin and used for different purposes, for their elemental contents, by neutron activation analysis. (author).

  17. Instrumental Neutron Activation Analysis Technique using Subsecond Radionuclides

    Nielsen, H.K.; Schmidt, J.O.


    The fast irradiation facility Mach-1 installed at the Danish DR 3 reactor has been used in boron determinations by means of Instrumental Neutron Activation Analysis using12B with 20-ms half-life. The performance characteristics of the system are presented and boron determinations of NBS standard...

  18. Accession Medical Standards Analysis and Research Activity Annual Report 2001


    The Accession Medical Standards Analysis and Research Activity annual Report 2001 summarizes work done to support the development of evidence-based...Hepatitis, Temporomandibular Disorders, Thyroid Disorders, Diabetes Mellitus, Abnormal Pap Smear, Enuresis, and Varicocele. Over 1,575,000 enlisted

  19. Application of prompt gamma-ray activation analysis

    Chung, Yong Sam; Park, Kwang Won; Moon, Jong Hwa; Kim, Sun Ha; Baek, Sung Ryel [Korea Atomic Energy Research Institute, Taejeon (Korea)


    This technical report is written for the promotion to utilization of prompt gamma-ray activation analysis facility to be installed in HANARO reactor. It is described for a practical aspects including experiment and equipments, methodology, current status of the research and development and its applications. 102 refs., 32 figs., 25 tabs. (Author)

  20. First principles and DFT supported investigations on vibrational spectra and electronic structure of 2-((phenylamino)methyl)isoindoline-1,3-dione - An antioxidant active Mannich base

    Boobalan, Maria susai; Amaladasan, M.; Ramalingam, S.; Tamilvendan, D.; Venkatesa Prabhu, G.; Bououdina, M.


    The 2-((phenylamino)methyl)isoindoline-1,3-dione (PID) is a synthesized Mannich base which has significant antioxidant activity and biological importance. Quantum mechanical calculations on energy, geometry and vibrational wavenumber of PID were computed using ab initio HF and density functional theory (DFT/B3LYP) methods with 6-31+G/6-311++G(d,p) basis sets. Optimized geometrical parameters obtained by HF and DFT calculations were indicatively agreement with experimental crystal geometry. The experimental FT-Raman and FT-IR spectra of PID has been recorded and analyzed by comparing with simulated spectra. The 1H and 13C NMR spectra of title molecule records the chemical shift resulted from shielding and deshielding effects. Natural bond orbital (NBO) analysis has been carried out to calculate various intramolecular interactions that are accountable for the stabilization of this Mannich base. The predicted HOMO-LUMO gap offers interesting information on intramolecular charge transfer and reactivity of the molecular system. Molecular electrostatic potential (MEP) imprint visualize the reactive sites in PID, which is also supported by Mulliken, ESP, Hirshfeld and NBO charges. Thermodynamic properties of PID at various temperatures have been calculated at B3LYP/6-311++G(d,p) in gas phase and the correlations between standard entropies (S), internal energy (E or U) and standard heat capacity (C) with different temperatures.

  1. Application of the principles of systems biology and Wiener's cybernetics for analysis of regulation of energy fluxes in muscle cells in vivo.

    Guzun, Rita; Saks, Valdur


    The mechanisms of regulation of respiration and energy fluxes in the cells are analyzed based on the concepts of systems biology, non-equilibrium steady state kinetics and applications of Wiener's cybernetic principles of feedback regulation. Under physiological conditions cardiac function is governed by the Frank-Starling law and the main metabolic characteristic of cardiac muscle cells is metabolic homeostasis, when both workload and respiration rate can be changed manifold at constant intracellular level of phosphocreatine and ATP in the cells. This is not observed in skeletal muscles. Controversies in theoretical explanations of these observations are analyzed. Experimental studies of permeabilized fibers from human skeletal muscle vastus lateralis and adult rat cardiomyocytes showed that the respiration rate is always an apparent hyperbolic but not a sigmoid function of ADP concentration. It is our conclusion that realistic explanations of regulation of energy fluxes in muscle cells require systemic approaches including application of the feedback theory of Wiener's cybernetics in combination with detailed experimental research. Such an analysis reveals the importance of limited permeability of mitochondrial outer membrane for ADP due to interactions of mitochondria with cytoskeleton resulting in quasi-linear dependence of respiration rate on amplitude of cyclic changes in cytoplasmic ADP concentrations. The system of compartmentalized creatine kinase (CK) isoenzymes functionally coupled to ANT and ATPases, and mitochondrial-cytoskeletal interactions separate energy fluxes (mass and energy transfer) from signalling (information transfer) within dissipative metabolic structures - intracellular energetic units (ICEU). Due to the non-equilibrium state of CK reactions, intracellular ATP utilization and mitochondrial ATP regeneration are interconnected by the PCr flux from mitochondria. The feedback regulation of respiration occurring via cyclic fluctuations of


    付兵; 王振宇


    主要给出饱和多孔微极介质波动方程变分所对应的泛函表达式和有限元离散化方程。首先对u-U形式的饱和多孔微极介质波动方程和边界条件进行Laplace变换,形成力学中的非齐次边值问题,然后构造变分后满足波动方程和边界条件的泛函,最后将有限元插值形式代入泛函表达式得到单元体的有限元离散方程。此方程对微极饱和多孔介质的动力固结问题数值分析具有重要意义。%Functional representations corresponding to the variational principle for the elastic pragmatic wave equations of saturated porous micro-polar medium and their discretized equations obtained by the f'mite element method are presented here. Firstly, the dynamic consolidation equations of saturated micro-polar soil given by u-U format and the relevant boundary conditions are transformed by Laplace transformation, so the non-homogeneous boundary problems in mechanics are engendered. Next, the function which satisfy the wave equations and boundary conditions after variation are composed through mathematic theory. In the end, the interpolation forms of the finite element method are inserted into the functional representations and the discretized equations of an element are obtained. It is significant for the numerical analysis on dynamic consolidation problems of saturated porous micro-polar medium.

  3. In-beam activation analysis facility at MLZ, Garching

    Révay, Zs., E-mail: [Heinz Maier-Leibniz Zentrum (MLZ), Technische Universität München, 85748 Garching (Germany); Kudějová, P.; Kleszcz, K.; Söllradl, S. [Heinz Maier-Leibniz Zentrum (MLZ), Technische Universität München, 85748 Garching (Germany); Genreith, Christoph [Heinz Maier-Leibniz Zentrum (MLZ), Technische Universität München, 85748 Garching (Germany); Institute of Energy and Climate Research, IEK-6: Nuclear Waste and Reactor Safety Fuel Cycle, Forschungszentrum Jülich GmbH in der Helmholtz-Gemeinschaft, 52428 Jülich (Germany)


    The reconstruction of the prompt gamma activation analysis facility and the construction of the new low-background counting chamber at MLZ, Garching is presented. The improvement of the shielding and its effect on the radiation background is shown. The setting up and the fine-tuning of the electronics and their characterization are also discussed. The upgraded facility has been demonstrated to be applicable for both PGAA and neutron activation analysis using in-beam activation and decay counting in the low-background counting chamber. - Highlights: • Radiation background at the PGAA facility was efficiently reduced. • In-beam irradiation facility in the strongest neutron beam. • The best signal-to-background ratio at a PGAA facility was achieved.

  4. Development of HANARO Activation Analysis System and Utilization Technology

    Chung, Y. S.; Moon, J. H.; Cho, H. J. (and others)


    1. Establishment of evaluation system using a data for a neutron activation analysis : Improvement of NAA measurement system and its identification, Development of combined data evaluation code of NAA/PGAA, International technical cooperation project 2. Development of technique for a industrial application of high precision gamma nuclide spectroscopic analysis : Analytical quality control, Development of industrial application techniques and its identification 3. Industrial application research for a prompt gamma-ray activation analysis : Improvement of Compton suppression counting system (PGAA), Development of applied technology using a PGAA system 4. Establishment of NAA user supporting system and KOLAS management : Development and validation of KOLAS/ISO accreditation testing and identification method, Cooperation researches for a industrial application, Establishment of integrated user analytical supporting system, Accomplishment of sample irradiation facility.

  5. Biomedical engineering principles

    Ritter, Arthur B; Valdevit, Antonio; Ascione, Alfred N


    Introduction: Modeling of Physiological ProcessesCell Physiology and TransportPrinciples and Biomedical Applications of HemodynamicsA Systems Approach to PhysiologyThe Cardiovascular SystemBiomedical Signal ProcessingSignal Acquisition and ProcessingTechniques for Physiological Signal ProcessingExamples of Physiological Signal ProcessingPrinciples of BiomechanicsPractical Applications of BiomechanicsBiomaterialsPrinciples of Biomedical Capstone DesignUnmet Clinical NeedsEntrepreneurship: Reasons why Most Good Designs Never Get to MarketAn Engineering Solution in Search of a Biomedical Problem

  6. Principles of dynamics

    Hill, Rodney


    Principles of Dynamics presents classical dynamics primarily as an exemplar of scientific theory and method. This book is divided into three major parts concerned with gravitational theory of planetary systems; general principles of the foundations of mechanics; and general motion of a rigid body. Some of the specific topics covered are Keplerian Laws of Planetary Motion; gravitational potential and potential energy; and fields of axisymmetric bodies. The principles of work and energy, fictitious body-forces, and inertial mass are also looked into. Other specific topics examined are kinematics

  7. Modern electronic maintenance principles

    Garland, DJ


    Modern Electronic Maintenance Principles reviews the principles of maintaining modern, complex electronic equipment, with emphasis on preventive and corrective maintenance. Unfamiliar subjects such as the half-split method of fault location, functional diagrams, and fault finding guides are explained. This book consists of 12 chapters and begins by stressing the need for maintenance principles and discussing the problem of complexity as well as the requirements for a maintenance technician. The next chapter deals with the connection between reliability and maintenance and defines the terms fai

  8. Artifact suppression and analysis of brain activities with electroencephalography signals

    Md. Rashed-Al-Mahfuz; Md. Rabiul Islam; Keikichi Hirose; Md. Khademul Islam Molla


    Brain-computer interface is a communication system that connects the brain with computer (or other devices) but is not dependent on the normal output of the brain (i.e., peripheral nerve and muscle). Electro-oculogram is a dominant artifact which has a significant negative influence on further analysis of real electroencephalography data. This paper presented a data adaptive technique for artifact suppression and brain wave extraction from electroencephalography signals to detect regional brain activities. Empirical mode decomposition based adaptive thresholding approach was employed here to suppress the electro-oculogram artifact. Fractional Gaussian noise was used to determine the threshold level derived from the analysis data without any training. The purified electroencephalography signal was composed of the brain waves also called rhythmic components which represent the brain activities. The rhythmic components were extracted from each electroencephalography channel using adaptive wiener filter with the original scale. The regional brain activities were mapped on the basis of the spatial distribution of rhythmic components, and the results showed that different regions of the brain are activated in response to different stimuli. This research analyzed the activities of a single rhythmic component, alpha with respect to different motor imaginations. The experimental results showed that the proposed method is very efficient in artifact suppression and identifying individual motor imagery based on the activities of alpha component.

  9. Analysis of Some Egyptian Cosmetic Samples by Fast Neutron Activation Analysis

    Medhat, M E; Fayez-Hassan, M


    A description of D-T neutron generator (NG) is presented. This generator can be used for fast neutron activation analysis applied to determine some selected elements, especially light elements, in different materials. In our work, the concentration of the elements Na, Mg, Al, Si, K, Cl, Ca and Fe, were determined in two domestic brands of face powder by using 14 MeV neutron activation analysis.


    Venkanna Lunavath


    Full Text Available The trend of using natural products has increased and the active plant extracts are frequently screened for new drug discoveries. The present study deals with the screening of Casia occidentalis leaves for their antimicrobial activity against various strains of bacteria. Plant Cassia occidentalis belongs to family Caesalpiniaceae, is a diffuse offensively odorous under shrub. Casia occidentalis were shade dried, powered and was extracted using solvents Methanol. The antimicrobial activity test performed by the disc diffusion method. Preliminary phytochemical analysis of the plant extracts fractions of HXF, CTF, CFF and AQF showed the presence of carbohydrates, amino acids, phytosterols, fixed oils and phenolic compounds. The AQF fraction of C. occidentalis showed high activity across pseudomonas aeuruginosa and staphylococcus aureus bacteria. The present study indicates the potential usefulness of Casia occidentalis leaves in the treatment of various diseases caused by micro-organisms.

  11. Principles Scientifiques, Principes Philosophiques

    Gilles-Gaston Granger


    Full Text Available A principle is a starting point of departure as well as a rule. In science principles are either alleged evident rules or generalizations of already accepted laws, or formal determinations for objects in a given domain. Thus two problems arise: first, does their nature have a conventional character? and sencond, what kind of truth is to be assigned to them. In philosophy principles are taken as a method of thinking as well as fundamental experiences. Even though they are points of departure, their true meaning is known only after a philosophical job is done. Thus, paradoxically enough, we can say that in both science and philosophy a principle is at the same time in the begining and in the end.

  12. The Symmetry Principle

    Joe Rosen


    Full Text Available Abstract: The symmetry principle is described in this paper. The full details are given in the book: J. Rosen, Symmetry in Science: An Introduction to the General Theory (Springer-Verlag, New York, 1995.

  13. Archimedes' Principle in Action

    Kires, Marian


    The conceptual understanding of Archimedes' principle can be verified in experimental procedures which determine mass and density using a floating object. This is demonstrated by simple experiments using graduated beakers. (Contains 5 figures.)

  14. Multifractal detrended fluctuation analysis of optogenetic modulation of neural activity

    Kumar, S.; Gu, L.; Ghosh, N.; Mohanty, S. K.


    Here, we introduce a computational procedure to examine whether optogenetically activated neuronal firing recordings could be characterized as multifractal series. Optogenetics is emerging as a valuable experimental tool and a promising approach for studying a variety of neurological disorders in animal models. The spiking patterns from cortical region of the brain of optogenetically-stimulated transgenic mice were analyzed using a sophisticated fluctuation analysis method known as multifractal detrended fluctuation analysis (MFDFA). We observed that the optogenetically-stimulated neural firings are consistent with a multifractal process. Further, we used MFDFA to monitor the effect of chemically induced pain (formalin injection) and optogenetic treatment used to relieve the pain. In this case, dramatic changes in parameters characterizing a multifractal series were observed. Both the generalized Hurst exponent and width of singularity spectrum effectively differentiates the neural activities during control and pain induction phases. The quantitative nature of the analysis equips us with better measures to quantify pain. Further, it provided a measure for effectiveness of the optogenetic stimulation in inhibiting pain. MFDFA-analysis of spiking data from other deep regions of the brain also turned out to be multifractal in nature, with subtle differences in the parameters during pain-induction by formalin injection and inhibition by optogenetic stimulation. Characterization of neuronal firing patterns using MFDFA will lead to better understanding of neuronal response to optogenetic activation and overall circuitry involved in the process.

  15. Microprocessors principles and applications

    Debenham, Michael J


    Microprocessors: Principles and Applications deals with the principles and applications of microprocessors and covers topics ranging from computer architecture and programmed machines to microprocessor programming, support systems and software, and system design. A number of microprocessor applications are considered, including data processing, process control, and telephone switching. This book is comprised of 10 chapters and begins with a historical overview of computers and computing, followed by a discussion on computer architecture and programmed machines, paying particular attention to t

  16. Heisenberg's observability principle

    Wolff, JE


    Werner Heisenberg's 1925 paper ‘Quantum-theoretical re-interpretation of kinematic and mechanical relations’ marks the beginning of quantum mechanics. Heisenberg famously claims that the paper is based on the idea that the new quantum mechanics should be ‘founded exclusively upon relationships between quantities which in principle are observable’. My paper is an attempt to understand this observability principle, and to see whether its employment is philosophically defensible. Against interpr...

  17. Ternary optical computer principle

    金翊; 何华灿; 吕养天


    The fundamental principle and the characteristics of ternary optical computer, using horizontal polarized light, vertical polarized light and no-intensity to express information, are propounded in thispaper. The practicability to make key parts of the ternary optical computer from modern micro or integrated optical devices, opto-electronic and electro-photonic elements is discussed. The principle can be applied in three-state optical fiber communication via horizontal and vertical polarized light.

  18. Electrical and electronic principles

    Knight, S A


    Electrical and Electronic Principles, 2, Second Edition covers the syllabus requirements of BTEC Unit U86/329, including the principles of control systems and elements of data transmission. The book first tackles series and parallel circuits, electrical networks, and capacitors and capacitance. Discussions focus on flux density, electric force, permittivity, Kirchhoff's laws, superposition theorem, arrangement of resistors, internal resistance, and powers in a circuit. The text then takes a look at capacitors in circuit, magnetism and magnetization, electromagnetic induction, and alternating v

  19. Electrical and electronic principles

    Knight, SA


    Electrical and Electronic Principles, 3 focuses on the principles involved in electrical and electronic circuits, including impedance, inductance, capacitance, and resistance.The book first deals with circuit elements and theorems, D.C. transients, and the series circuits of alternating current. Discussions focus on inductance and resistance in series, resistance and capacitance in series, power factor, impedance, circuit magnification, equation of charge, discharge of a capacitor, transfer of power, and decibels and attenuation. The manuscript then examines the parallel circuits of alternatin



    University textbook Principles of Animal Breeding is intended for students of agriculture and veterinary medicine. The material is the adapted curricula of undergraduate and graduate level studies in the framework of which the modules Principles of animal breeding as well as Basics of genetics and selection of animals attended are listened. The textbook contains 14 chapters and a glossary of terms. Its concept enables combining fundamental and modern knowledge in the ...

  1. Microwave system engineering principles

    Raff, Samuel J


    Microwave System Engineering Principles focuses on the calculus, differential equations, and transforms of microwave systems. This book discusses the basic nature and principles that can be derived from thermal noise; statistical concepts and binomial distribution; incoherent signal processing; basic properties of antennas; and beam widths and useful approximations. The fundamentals of propagation; LaPlace's Equation and Transmission Line (TEM) waves; interfaces between homogeneous media; modulation, bandwidth, and noise; and communications satellites are also deliberated in this text. This bo

  2. 2D design rule and layout analysis using novel large-area first-principles-based simulation flow incorporating lithographic and stress effects

    Prins, Steven L.; Blatchford, James; Olubuyide, Oluwamuyiwa; Riley, Deborah; Chang, Simon; Hong, Qi-Zhong; Kim, T. S.; Borges, Ricardo; Lin, Li


    As design rules and corresponding logic standard cell layouts continue to shrink node-on-node in accordance with Moore's law, complex 2D interactions, both intra-cell and between cells, become much more prominent. For example, in lithography, lack of scaling of λ/NA implies aggressive use of resolution enhancement techniques to meet logic scaling requirements-resulting in adverse effects such as 'forbidden pitches'-and also implies an increasing range of optical influence relative to cell size. These adverse effects are therefore expected to extend well beyond the cell boundary, leading to lithographic marginalities that occur only when a given cell is placed "in context" with other neighboring cells in a variable design environment [1]. This context dependence is greatly exacerbated by increased use of strain engineering techniques such as SiGe and dual-stress liners (DSL) to enhance transistor performance, both of which also have interaction lengths on the order of microns. The use of these techniques also breaks the formerly straightforward connection between lithographic 'shapes' and end-of-line electrical performance, thus making the formulation of design rules that are robust to process variations and complex 2D interactions more difficult. To address these issues, we have developed a first-principles-based simulation flow to study contextdependent electrical effects in layout, arising not only from lithography, but also from stress and interconnect parasitic effects. This flow is novel in that it can be applied to relatively large layout clips- required for context-dependent analysis-without relying on semi-empirical or 'black-box' models for the fundamental electrical effects. The first-principles-based approach is ideal for understanding contextdependent effects early in the design phase, so that they can be mitigated through restrictive design rules. The lithographic simulations have been discussed elsewhere [1] and will not be presented in detail. The

  3. Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive responses

    Sorribas Albert


    Full Text Available Abstract Background Optimization methods allow designing changes in a system so that specific goals are attained. These techniques are fundamental for metabolic engineering. However, they are not directly applicable for investigating the evolution of metabolic adaptation to environmental changes. Although biological systems have evolved by natural selection and result in well-adapted systems, we can hardly expect that actual metabolic processes are at the theoretical optimum that could result from an optimization analysis. More likely, natural systems are to be found in a feasible region compatible with global physiological requirements. Results We first present a new method for globally optimizing nonlinear models of metabolic pathways that are based on the Generalized Mass Action (GMA representation. The optimization task is posed as a nonconvex nonlinear programming (NLP problem that is solved by an outer-approximation algorithm. This method relies on solving iteratively reduced NLP slave subproblems and mixed-integer linear programming (MILP master problems that provide valid upper and lower bounds, respectively, on the global solution to the original NLP. The capabilities of this method are illustrated through its application to the anaerobic fermentation pathway in Saccharomyces cerevisiae. We next introduce a method to identify the feasibility parametric regions that allow a system to meet a set of physiological constraints that can be represented in mathematical terms through algebraic equations. This technique is based on applying the outer-approximation based algorithm iteratively over a reduced search space in order to identify regions that contain feasible solutions to the problem and discard others in which no feasible solution exists. As an example, we characterize the feasible enzyme activity changes that are compatible with an appropriate adaptive response of yeast Saccharomyces cerevisiae to heat shock Conclusion Our results

  4. Generalized uncertainty principles

    Machluf, Ronny


    The phenomenon in the essence of classical uncertainty principles is well known since the thirties of the last century. We introduce a new phenomenon which is in the essence of a new notion that we introduce: "Generalized Uncertainty Principles". We show the relation between classical uncertainty principles and generalized uncertainty principles. We generalized "Landau-Pollak-Slepian" uncertainty principle. Our generalization relates the following two quantities and two scaling parameters: 1) The weighted time spreading $\\int_{-\\infty}^\\infty |f(x)|^2w_1(x)dx$, ($w_1(x)$ is a non-negative function). 2) The weighted frequency spreading $\\int_{-\\infty}^\\infty |\\hat{f}(\\omega)|^2w_2(\\omega)d\\omega$. 3) The time weight scale $a$, ${w_1}_a(x)=w_1(xa^{-1})$ and 4) The frequency weight scale $b$, ${w_2}_b(\\omega)=w_2(\\omega b^{-1})$. "Generalized Uncertainty Principle" is an inequality that summarizes the constraints on the relations between the two spreading quantities and two scaling parameters. For any two reason...

  5. Offgas Analysis and Pyrolysis Mechanism of Activated Carbon from Bamboo Sawdust by Chemical Activation With KOH

    TIAN Yong; LIU Ping; WANG Xiufang; ZHONG Guoying; CHEN Guanke


    Bamboo sawdust was used as the precursor for the multipurpose use of waste.Offgases released during the activation process of bamboo by KOH were investigated quantitatively and qualitatively by a gas analyzer. TG/DTG curves during the pyrolysis process with different impregnation weight ratios (KOH to bamboo) were obtained by a thermogravimetric analyzer. Pyrolysis mechanism of bamboo was proposed. The results showed that the offgases were composed of CO, NO,SO2 and hydrocarbon with the concentration of 1 372, 37, 86, 215 mg/L, respectively. Thermogravimetric analysis indicated that the pyrolytic process mainly experienced two steps. The first was the low temperature activation step (lower than 300 ℃), which was the pre-activation and induction period.The second was the high temperature activation step(higher than 550 ℃), which was a radial activation followed by pore production. The second process was the key to control the pore distribution of the final product.

  6. Development and coupling analysis of active skin antenna

    Zhou, Jinzhu; Huang, Jin; He, Qingqang; Tang, Baofu; Song, Liwei


    An active skin antenna is a multifunctional composite structure that can provide load-bearing structure and steerable beam pointing functions, and is usually installed in the structural surface of aircraft, warships, and armored vehicles. This paper presents an innovative design of the active skin antenna, which consists of a package layer, control and signal processing layer, and RF (radio frequency) layer. The RF layer is fabricated by low temperature co-fired ceramics, with 64 microstrip antenna elements, tile transmitting and receiving modules, microchannel heat sinks, and feeding networks integrated into a functional block 2.8 mm thick. In this paper, a full-sized prototype of an active skin antenna was designed, fabricated, and tested. Moreover, a coupling analysis method was presented to evaluate the mechanical and electromagnetic performance of the active skin antenna subjected to aerodynamic loads. A deformed experimental system was built to validate the effectiveness of the coupling analysis method, which was also implemented to evaluate the performance of the active skin antenna when subjected to aerodynamic pressure. The fabricated specimen demonstrated structural configuration feasibility, and superior environmental load resistance.

  7. Analysis of alternatives for immobilized low activity waste disposal

    Burbank, D.A.


    This report presents a study of alternative disposal system architectures and implementation strategies to provide onsite near-surface disposal capacity to receive the immobilized low-activity waste produced by the private vendors. The analysis shows that a flexible unit strategy that provides a suite of design solutions tailored to the characteristics of the immobilized low-activity waste will provide a disposal system that best meets the program goals of reducing the environmental, health, and safety impacts; meeting the schedule milestones; and minimizing the life-cycle cost of the program.

  8. Multi-scale statistical analysis of coronal solar activity

    Gamborino, Diana; del-Castillo-Negrete, Diego; Martinell, Julio J.


    Multi-filter images from the solar corona are used to obtain temperature maps that are analyzed using techniques based on proper orthogonal decomposition (POD) in order to extract dynamical and structural information at various scales. Exploring active regions before and after a solar flare and comparing them with quiet regions, we show that the multi-scale behavior presents distinct statistical properties for each case that can be used to characterize the level of activity in a region. Information about the nature of heat transport is also to be extracted from the analysis.

  9. Analysis of Usnea fasciata crude extracts with antineoplastic activity.

    Periera, E C; Nascimento, S C; Lima, R C; Silva, N H; Oliveira, A F; Bandeira, E; Boitard, M; Beriel, H; Vicente, C; Legaz, M E


    Different fractions, isolated from the lichen Usnea fasciata, were analyzed by PC, TLC, and RP-HPLC. Analysis of the organic phases, mainly containing phenolics, revealed that usnic acid is the main product from secondary metabolites, whereas the polysaccharides isolichenin and raffinose are the most abundant water-soluble carbohydrates. Fractions containing usnic acid, as well as those containing isolichenin, showed moderate activity against sarcoma 180 and Ehrlich tumor cells. High antitumoral activity, near 90% inhibition, was found associated with the fraction containing raffinose.

  10. 事件相关电位测谎技术原理探析%Principle analysis of the event-related potentials lie detection technology

    卜令章; 刘洪广


    At present,the domestic research for the event-related potentials(ERPs)lie detection technology mainly focuses on the method of design and application of exploration,less from the principle perspective to carry on the comprehensive analysis.The article has carried on a deep analysis of the theory of ERPs lie detection technology on the basis of interpreting the ERPs lie detection and believes it is mainly related to two cognitive processes which involve the recognition of memory and cheating reaction. Because the suspect has the memory to the case ,the first cognitive processe of the suspect is the recognition of memory when displaying the case related information to him. Then ,the suspect have to make cheating reactions which inconsistent with his cognition,in order to pass the test of lie detection.When processing the recognition of memory and cheating reaction ,the brain of the suspect will produce ERPs(Dm,P300,N400 etc.)which show significant differences between relevant information and irrelevant information.And these elements are to distinguish whether he is really involved.A main task of ERPs lie detection research is to innovative methods to discover and select effective electrical components which can distinguish whether a subject has the memory of the case or whether he make a cheating.According to it ,the examiner can find who has invovled in the case. Previous studies mostly analyzed separately the recognition memory or deceit,the article summarizes the relevant research on memory recognition and cheating.By analyzing the ERPs which reported by ever studys,the article believes that researher should foucus their eyes on the combined analysis analysis of recognition memory and deceit in the futhure.Generally,the rigor and scientificity of the ERPs lie detection technology were comprehensivly discussed in a theoretic perspective in the article.It will further improve the efficiency of event related potentials lie detection technology and has important

  11. Digital methods of photopeak integration in activation analysis.

    Baedecker, P. A.


    A study of the precision attainable by several methods of gamma-ray photopeak integration has been carried out. The 'total peak area' method, the methods proposed by Covell, Sterlinski, and Quittner, and some modifications of these methods have been considered. A modification by Wasson of the total peak area method is considered to be the most advantageous due to its simplicity and the relatively high precision obtainable with this technique. A computer routine for the analysis of spectral data from nondestructive activation analysis experiments employing a Ge(Li) detector-spectrometer system is described.

  12. Active Greens : An Analysis of the Determinants of Green Party Members' Activism in Environmental Movements

    Botetzagias, Iosif; van Schuur, Wijbrandt


    This article investigates green party members' activism in the environmental movement and tests how a number of predictors, theoretically suggested in the past yet rarely empirically tested, can account for it. The authors' analysis is based on an extensive data set of members of 15 green parties in

  13. Hydrotectonics; principles and relevance

    Kopf, R.W.


    Hydrotectonics combines the principles of hydraulics and rock mechanics. The hypothesis assumes that: (1) no faults are truly planar, (2) opposing noncongruent wavy wallrock surfaces form chambers and bottlenecks along the fault, and (3) most thrusting occurs beneath the water table. These physical constraints permit the following dynamics. Shear displacement accompanying faulting must constantly change the volume of each chamber. Addition of ground water liquefies dry fault breccia to a heavy incompressible viscous muddy breccia I call fault slurry. When the volume of a chamber along a thrust fault decreases faster than its fault slurry can escape laterally, overpressurized slurry is hydraulically injected into the base of near-vertical fractures in the otherwise impervious overriding plate. Breccia pipes commonly form where such fissures intersect. Alternating decrease and increase in volume of the chamber subjects this injection slurry to reversible surges that not only raft and abrade huge clasts sporadically spalled from the walls of the conduit but also act as a forceful hydraulic ram which periodically widens the conduit and extends its top. If the pipe perforates a petroleum reservoir, leaking hydrocarbons float to its top. Sudden faulting may generate a powerful water hammer that can be amplified at some distal narrow ends of the anastomosing plumbing system, where the shock may produce shatter cones. If vented on the Earth's surface, the muddy breccia, now called extrusion slurry, forms a mud volcano. This hypothesis suggests that many highly disturbed features presently attributed to such catastrophic processes as subsurface explosions or meteorite impacts are due to the rheology of tectonic slurry in an intermittently reactivated pressure-relief tube rooted in a powerful reciprocating hydrotectonic pump activated by a long-lived deep-seated thrust fault.

  14. Some Applications of Fast Neutron Activation Analysis of Oxygen

    Owrang, Farshid


    illustrated how the activated water would propagate along that pipe. C) Combustion products. In order to investigate the oxidation in combustion products (deposits), the total amount of oxygen in the deposits collected from combustion chambers of a modern gasoline engine was measured, using cyclic fast neutron activation analysis (FNAA). As a compartment, the organic compounds containing oxygen were identified using {sup 13}C solid-state nuclear magnetic resonance (NMR) spectroscopy. The results of FNAA showed that the amount of oxygen in deposits varies depending on where the deposits have been formed. {sup 13}C NMR has showed that the carbon backbone of the deposits exists as highly oxidized poly aromatics and/or graphitic structure. D) On-line fast neutron activation analysis. On-line neutron activation analysis was used to detect the amount of oxygen in bulk liquids. The method was optimised for on-line detection of oxygen in rapeseed oil. The goal was to develop a non-intrusive method for measurement of the total amount of oxygen in oil during combustion/oxidation.

  15. 浅析云盘技术及存储原理%Analysis of Cloud Disk Storage Technology and the Principle



    along with the computer technology and modern more advanced, cloud disk technology has penetrated into people's work, this article mainly discusses the principle of cloud storage technology, cloud and cloud disk storage space partition principle.%随着现代的计算机技术越来越先进,云盘的技术已经渗透到很多人的工作中,本篇文章主要来探讨云盘技术、云盘的储存原理以及云盘存储空间划分原理。

  16. Analysis of foreign physical activity recommendations and guidelines for schools

    Jan Pavelka


    Full Text Available Background:An adequate level of physical activity is an important part of children's lifestyle. The school environment plays a significant role in the area of interventions and strategies aiming to increase the level of physical activity in children. Objectives: The aim of this study is to analyse foreign recommendations leading to an increased level of physical activity in children and young people in Czech schools. Methods: A systematic search of studies published between 1988 and 2012 in the English language was completed in library databases Medline, Sport Discus, ProQuest, PsychInfo, ERIC, Wiley InterScience using the following keywords: physical activity, guidelines, recommendations, school and youth. The studies were then classified based on abstract and full-text analyses. Using a content analysis the expert team formulated the final recommendations to increase the level of physical activity for schools in the Czech Republic (CR. Results: Out of the total number of 91 identified foreign studies, 25 met the predetermined criteria and were used as a basis for formulating the recommendations. These foreign studies included 15 papers published in USA, two in Australia, two in Great Britain, two in Canada, one in the European Union, one in New Zealand and one international paper (an international consensus of experts from 34 countries. Based on the interpretation of the evidence, its justification and final consensus of the expert team, the basic areas for the recommendations to increase the level of physical activity in schools in the CR were identified. Conclusions: An analysis of foreign recommendations to increase the level of physical activity designed for schools and school facilities is one of the possible methods of formulating domestic recommendations. This recommendation could contribute to deeper understanding of the issue of the deteriorating lifestyle of school-aged children in the CR and reflects the efforts for improvement.

  17. Adult active transport in the Netherlands: an analysis of its contribution to physical activity requirements.

    Elliot Fishman

    Full Text Available Modern, urban lifestyles have engineered physical activity out of everyday life and this presents a major threat to human health. The Netherlands is a world leader in active travel, particularly cycling, but little research has sought to quantify the cumulative amount of physical activity through everyday walking and cycling.Using data collected as part of the Dutch National Travel Survey (2010 - 2012, this paper determines the degree to which Dutch walking and cycling contributes to meeting minimum level of physical activity of 150 minutes of moderate intensity aerobic activity throughout the week. The sample includes 74,465 individuals who recorded at least some travel on the day surveyed. As physical activity benefits are cumulative, all walking and cycling trips are analysed, including those to and from public transport. These trips are then converted into an established measure of physical activity intensity, known as metabolic equivalents of tasks. Multivariate Tobit regression models were performed on a range of socio-demographic, transport resources, urban form and meteorological characteristics.The results reveal that Dutch men and women participate in 24 and 28 minutes of daily physical activity through walking and cycling, which is 41% and 55% more than the minimum recommended level. It should be noted however that some 57% of the entire sample failed to record any walking or cycling, and an investigation of this particular group serves as an important topic of future research. Active transport was positively related with age, income, bicycle ownership, urban density and air temperature. Car ownership had a strong negative relationship with physically active travel.The results of this analysis demonstrate the significance of active transport to counter the emerging issue of sedentary lifestyle disease. The Dutch experience provides other countries with a highly relevant case study in the creation of environments and cultures that

  18. Analyses of Oxyanion Materials by Prompt Gamma Activation Analysis

    Firestone, Richard B; Perry, D.L.; English, G.A.; Firestone, R.B.; Leung, K.-N.; Garabedian, G.; Molnar, G.L.; Revay, Zs.


    Prompt gamma activation analysis (PGAA) has been used to analyze metal ion oxyanion materials that have multiple applications, including medicine, materials, catalysts, and electronics. The significance for the need for accurate, highly sensitive analyses for the materials is discussed in the context of quality control of end products containing the parent element in each material. Applications of the analytical data for input to models and theoretical calculations related to the electronic and other properties of the materials are discussed.

  19. Diagnostic Application of Absolute Neutron Activation Analysis in Hematology

    Zamboni, C.B.; Oliveira, L.C.; Dalaqua, L. Jr.


    The Absolute Neutron Activation Analysis (ANAA) technique was used to determine element concentrations of Cl and Na in blood of healthy group (male and female blood donators), select from Blood Banks at Sao Paulo city, to provide information which can help in diagnosis of patients. This study permitted to perform a discussion about the advantages and limitations of using this nuclear methodology in hematological examinations.

  20. Antitumor activity of 3,4-ethylenedioxythiophene derivatives and quantitative structure-activity relationship analysis

    Jukić, Marijana; Rastija, Vesna; Opačak-Bernardi, Teuta; Stolić, Ivana; Krstulović, Luka; Bajić, Miroslav; Glavaš-Obrovac, Ljubica


    The aim of this study was to evaluate nine newly synthesized amidine derivatives of 3,4- ethylenedioxythiophene (3,4-EDOT) for their cytotoxic activity against a panel of human cancer cell lines and to perform a quantitative structure-activity relationship (QSAR) analysis for the antitumor activity of a total of 27 3,4-ethylenedioxythiophene derivatives. Induction of apoptosis was investigated on the selected compounds, along with delivery options for the optimization of activity. The best obtained QSAR models include the following group of descriptors: BCUT, WHIM, 2D autocorrelations, 3D-MoRSE, GETAWAY descriptors, 2D frequency fingerprint and information indices. Obtained QSAR models should be relieved in elucidation of important physicochemical and structural requirements for this biological activity. Highly potent molecules have a symmetrical arrangement of substituents along the x axis, high frequency of distance between N and O atoms at topological distance 9, as well as between C and N atoms at topological distance 10, and more C atoms located at topological distances 6 and 3. Based on the conclusion given in the QSAR analysis, a new compound with possible great activity was proposed.