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Sample records for actinium 224

  1. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  2. Spectroscopic and computational investigation of actinium coordination chemistry

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  3. Spectroscopic and computational investigation of actinium coordination chemistry

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  4. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development.

  5. Relativistic small-core pseudopotentials for actinium, thorium, and protactinium.

    Weigand, Anna; Cao, Xiaoyan; Hangele, Tim; Dolg, Michael

    2014-04-03

    Small-core pseudopotentials for actinium, thorium, and protactinium have been energy-adjusted to multiconfiguration Dirac-Hartree-Fock reference data based on the Dirac-Coulomb-Breit Hamiltonian and the Fermi nucleus model. Corresponding optimized valence basis sets of polarized valence quadruple-ζ quality are presented. Atomic test calculations for the first four ionization potentials show satisfactory results at both the Hartree-Fock and the multireference averaged coupled-pair functional level. Highly correlated Fock-space coupled cluster calculations demonstrate that the new pseudopotentials yield ionization potentials, which are in excellent agreement with corresponding all-electron results and experimental data. The pseudopotentials and basis sets supplement a similar set previously published for uranium.

  6. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  7. 22 CFR 224.34 - Evidence.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Evidence. 224.34 Section 224.34 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224... probative value is substantially outweighed by the danger of unfair prejudice, confusion of the issues,...

  8. 9 CFR 354.224 - Water supply.

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at...

  9. 49 CFR 195.224 - Welding: Weather.

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions...

  10. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  11. 42 CFR 93.224 - Research record.

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Research record. 93.224 Section 93.224 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  12. Dicty_cDB: SSI224 [Dicty_cDB

    Full Text Available SS (Link to library) SSI224 (Link to dictyBase) - - - - SSI224Z (Link to Original site) - - SSI...las ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSI2-A/SSI...224Q.Seq.d/ Representative seq. ID SSI224Z (Link to Original site) R...DNA Score E Sequences producing significant alignments: (bits) Value SSI224 (SSI224Q) /CSM/SS/SSI2-A/SSI224Q...%: mitochondrial 8.0 %: cytoskeletal 4.0 %: vacuolar 4.0 %: vesicles of secretory system >> prediction for SSI

  13. 49 CFR 571.224 - Standard No. 224; Rear impact protection.

    2010-10-01

    ... mm of the longitudinal vertical planes that are tangent to the side extremities of the vehicle. See... TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE SAFETY STANDARDS Federal Motor Vehicle Safety Standards § 571.224 Standard No. 224; Rear impact protection. S1. Scope....

  14. Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes.

    Radchenko, V; Engle, J W; Wilson, J J; Maassen, J R; Nortier, F M; Taylor, W A; Birnbaum, E R; Hudston, L A; John, K D; Fassbender, M E

    2015-02-06

    Actinium-225 (t1/2=9.92d) is an α-emitting radionuclide with nuclear properties well-suited for use in targeted alpha therapy (TAT), a powerful treatment method for malignant tumors. Actinium-225 can also be utilized as a generator for (213)Bi (t1/2 45.6 min), which is another valuable candidate for TAT. Actinium-225 can be produced via proton irradiation of thorium metal; however, long-lived (227)Ac (t1/2=21.8a, 99% β(-), 1% α) is co-produced during this process and will impact the quality of the final product. Thus, accurate assays are needed to determine the (225)Ac/(227)Ac ratio, which is dependent on beam energy, irradiation time and target design. Accurate actinium assays, in turn, require efficient separation of actinium isotopes from both the Th matrix and highly radioactive activation by-products, especially radiolanthanides formed from proton-induced fission. In this study, we introduce a novel, selective chromatographic technique for the recovery and purification of actinium isotopes from irradiated Th matrices. A two-step sequence of cation exchange and extraction chromatography was implemented. Radiolanthanides were quantitatively removed from Ac, and no non-Ac radionuclidic impurities were detected in the final Ac fraction. An (225)Ac spike added prior to separation was recovered at ≥ 98%, and Ac decontamination from Th was found to be ≥ 10(6). The purified actinium fraction allowed for highly accurate (227)Ac determination at analytical scales, i.e., at (227)Ac activities of 1-100 kBq (27 nCi to 2.7 μCi).

  15. Iron status markers in 224 indigenous Greenlanders

    Milman, N; Byg, K E; Mulvad, G

    2001-01-01

    OBJECTIVE: To evaluate iron status in indigenous Greenlanders and its relationship to gender, age and intake of traditional Greenlandic foods. Methods: Serum ferritin, serum transferrin saturation and haemoglobin were evaluated in a population survey in 1993-1994 comprising 224 Greenlandic...

  16. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  17. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Raeder, S., E-mail: s.raeder@gsi.de [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Bastin, B. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Block, M. [Helmholtz-Institut Mainz, 55128 Mainz (Germany); GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt (Germany); Institut für Kernchemie, Johannes Gutenberg Universität, 55128 Mainz (Germany); Creemers, P. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Delahaye, P. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); Ferrer, R. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fléchard, X. [LPC Caen, ENSICAEN, Université de Caen, CNRS/IN2P3, Caen (France); Franchoo, S. [Institute de Physique Nucléaire (IPN) d’Orsay, 91406 Orsay, Cedex (France); Ghys, L. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); SCK-CEN, Belgian Nuclear Research Center, Boeretang 200, 2400 Mol (Belgium); Gaffney, L.P.; Granados, C. [KU Leuven, Instituut voor Kern- en Stralingsfysica, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Heinke, R. [Institut für Physik, Johannes Gutenberg Universität, 55128 Mainz (Germany); Hijazi, L. [GANIL, CEA/DSM-CNRS/IN2P3, B.P. 55027, 14076 Caen (France); and others

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  18. 38 CFR 21.224 - Prevention of abuse.

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Prevention of abuse. 21.224 Section 21.224 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED... Supplies § 21.224 Prevention of abuse. Supplies are to be furnished under the most careful checks by...

  19. 40 CFR 86.224-94 - Carbon dioxide analyzer calibration.

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Carbon dioxide analyzer calibration. 86.224-94 Section 86.224-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.224-94 Carbon...

  20. 48 CFR 52.224-2 - Privacy Act.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Privacy Act. 52.224-2... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.224-2 Privacy... agency function: Privacy Act (APR 1984) (a) The Contractor agrees to— (1) Comply with the Privacy Act...

  1. 48 CFR 352.224-70 - Privacy Act.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Privacy Act. 352.224-70... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 352.224-70 Privacy Act. As prescribed in 324.103(b)(2), the Contracting Officer shall insert the following clause: Privacy Act...

  2. 22 CFR 224.44 - Right to administrative offset.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Right to administrative offset. 224.44 Section... CIVIL REMEDIES ACT § 224.44 Right to administrative offset. The amount of any penalty or assessment... offset under 31 U.S.C. 3716, except that an administrative offset may not be made under the...

  3. 29 CFR 500.224 - Referral to Administrative Law Judge.

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Referral to Administrative Law Judge. 500.224 Section 500... Hearing § 500.224 Referral to Administrative Law Judge. (a) Upon receipt of a timely request for a hearing... Administrative Law Judge, for a determination in an administrative proceeding as provided herein. The notice...

  4. 14 CFR 125.224 - Collision avoidance system.

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Collision avoidance system. 125.224 Section... Requirements § 125.224 Collision avoidance system. Effective January 1, 2005, any airplane you operate under this part 125 must be equipped and operated according to the following table: Collision...

  5. 25 CFR 224.171 - Who may rescind a TERA?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Who may rescind a TERA? 224.171 Section 224.171 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE... rescind a TERA? Only a tribe may rescind a TERA....

  6. 14 CFR 417.224 - Probability of failure analysis.

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Probability of failure analysis. 417.224..., DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.224 Probability of failure..., must account for launch vehicle failure probability in a consistent manner. A launch vehicle...

  7. 18 CFR 2.24 - Project decommissioning at relicensing.

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Project decommissioning at relicensing. 2.24 Section 2.24 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES GENERAL POLICY AND INTERPRETATIONS Statements of...

  8. Distribution of radium-224 in the western Arctic Ocean

    QIU Yusheng; CHEN Min; LI Yanping

    2005-01-01

    Radium-224 activities in the western Arctic Ocean were measured via ship-board 220Rn emanation technique during the Second Chinese National Arctic Expedition. The results showed that the 224Ra activities in the study areas ranged from being less than 0.08 to 3.58 Bq/m3, with an average of 0.23 Bq/m3. The low 224Ra concentration in the surface water was attributed to the influence of sea ice melted water. The horizontal distribution of surface 224Ra in the western Arctic Ocean showed a high 224Ra characteristics occurred along the slope around 160°W, providing evidence for the importance of ice-rafted sediments to controlling the distribution of radium isotopes in the Arctic Ocean. Mostly, 224Ra concentrations increased with the depth in the shelf region and reached a maximum at 75 m at the central Canada Basin, which further confirms the importance of the transport of shelf bottom water to maintaining the upper halocline layer in the Canada Basin.

  9. DF-224 Version 7.3 FS Installation

    Boyce, Leslye

    1990-12-01

    Version 7.3 will implement a three logical memory unit contingency plan. It removes under utilized DF-224 code to recover memory margins and restructures code. The installation of DF-224, version 7.3 will be broken into a Installation, Regression test, and Contingency Back-out time. In addition, it eliminates the 10 and 300 second processing rate. It is highly desirable to implement the version of the flight software ASAP. Due to the complexity of the installation, dedicated spacecraft time is required to minimize spacecraft risk In summary, this proposal requests 14 orbits of dedicated spacecraft time for installation, regression test, and contingency back_out time for DF-224 FS V7.3 to be scheduled in the first few days of SMS 054.

  10. 40 CFR 60.224 - Test methods and procedures.

    2010-07-01

    ... (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for the Phosphate Fertilizer Industry: Diammonium Phosphate Plants § 60.224 Test methods and procedures. (a) In conducting the.../hr). K=conversion factor, 1000 mg/g (7,000 gr/lb). (2) Method 13A or 13B shall be used to...

  11. DF-224 Version 8.0 FS Installation

    Boyce, Leslye

    1990-12-01

    DF-224 Version 8.0 will implement the final phase of the 3 Logical Memory Unit Contingency Plan described in LMSC,EM SPS640. It focuses on new capabilities, implementing a spin stabilized safemode, correcting the integral calculation in Momentum Management Law and other miscellaneous command changes geared at enhancing acquistions and science. Due to the complexity of the installation, dedicated space-craft time is required to minimize risk. In summary, this proposal requests 7 orbits of dedicated spacecraft time for installation, regression testing and contingency back-out time for DF-224 Flight Software (FS) Version 8.0 for the week of April 27,(SMS118). No dedicated time is requested for the pre-load of the FS.

  12. Treatment of ankylosing spondylitis with [{sup 224}Ra]-Radiumchloride; Therapie der Spondylitis ankylosans mit [{sup 224}Ra]-Radiumchlorid

    Reiners, C. [Klinik und Poliklinik fuer Nuklearmedizin der Univ. Wuerzburg (Germany); Braun, J. [Rheumazentrum Ruhrgebiet Herne (Germany)

    2001-07-01

    Ankylosing spondylitis (AS) is a chronic disease which in 30-50% of the patients leads to considerable episodes of pain, a remarkable reduction of quality of life and disablement. For treatment mostly nonsteroidal antiphlogistic drugs are used which are able to reduce pain in approximately 80% of the patients only. Those drugs however, have to be withdrawn in approximately 30% of the patients due to its known toxicity (mainly in the gastrointestinal tract). Basis medication (DMARDs) is helpful in a minority of AS patients only. Recently [{sup 224}Ra]-Radiumchloride, which has been used previously between 1955 and 1990, has been made available again for treatment of AS. Whereas biokinetics, radiation exposure and the risk-profile of [{sup 224}Ra]-Radiumchloride are documented well by experimental and clinical data, most of the historical studies about the efficacy of this radiopharmaceutical do not fulfill the requirements of modern therapy studies. Therefore as many patients as possible should be recruited for a prospective long-time Phase IV study. A close and well-coordinated cooperation between rheumatologists and nuclear medicine physicians is needed, when [{sup 224}Ra]-Radiumchloride is used for treatment of AS. (orig.) [German] Die meist chronisch, oft auch in Schueben verlaufende Spondylitis ankylosans (AS) fuehrt bei 30-50% der Patienten zu betraechtlichen Schmerzen und einer nicht selten erheblichen Einschraenkung der Lebensqualitaet und Behinderung. Die am haeufigsten zur Therapie verwendeten nichtsteroidalen Antiphlogistika koennen nur bei etwa 80% der Patienten die Schmerzen lindern. Allerdings muessen diese Medikamente bei 20-30% der AS-Patienten wegen ihrer bekannten Toxizitaet - vor allem im Gastrointestinaltrakt - abgesetzt werden. Basistherapeutika (DMARDs) helfen bei der AS nur sehr begrenzt. Mit [{sup 224}Ra]-Radiumchlorid steht seit kurzem ein bereits in den Jahren 1945-1990 fuer die Behandlung der AS verwendetes Radiopharmakon wieder zur

  13. 18 CFR 284.224 - Certain transportation and sales by local distribution companies.

    2010-04-01

    ... and sales by local distribution companies. 284.224 Section 284.224 Conservation of Power and Water... Transportation by Interstate Pipelines on Behalf of Others and Services by Local Distribution Companies § 284.224 Certain transportation and sales by local distribution companies. (a) Applicability. This section...

  14. 50 CFR 224.105 - Speed restrictions to protect North Atlantic Right Whales.

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Speed restrictions to protect North Atlantic Right Whales. 224.105 Section 224.105 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE... AND ANADROMOUS SPECIES § 224.105 Speed restrictions to protect North Atlantic Right Whales. (a)...

  15. 25 CFR 224.68 - How will the Secretary use public comments?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will the Secretary use public comments? 224.68 Section 224.68 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL... Procedures for Obtaining Tribal Energy Resource Agreements Public Notification and Comment § 224.68 How...

  16. 47 CFR 68.224 - Notice of non-hearing aid compatibility.

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Notice of non-hearing aid compatibility. 68.224 Section 68.224 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES... § 68.224 Notice of non-hearing aid compatibility. Every non-hearing aid compatible telephone...

  17. 50 CFR 224.103 - Special prohibitions for endangered marine mammals.

    2010-10-01

    ... mammals. 224.103 Section 224.103 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS ENDANGERED MARINE AND ANADROMOUS SPECIES § 224.103 Special prohibitions for endangered marine mammals. (a) Approaching...

  18. 78 FR 31627 - Twenty-Second Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2013-05-24

    ...: RTCA Special Committee 224, Airport Security Access Control Systems AGENCY: Federal Aviation... 224, Airport Security Access Control Systems. SUMMARY: The FAA is issuing this notice to advise the public of the twenty-second meeting of the RTCA Special Committee 224, Airport Security Access...

  19. 25 CFR 224.62 - May a final proposed TERA differ from the original proposed TERA?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false May a final proposed TERA differ from the original proposed TERA? 224.62 Section 224.62 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY... § 224.62 May a final proposed TERA differ from the original proposed TERA? The final proposed TERA...

  20. 25 CFR 224.160 - How will reassumption affect a TERA?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will reassumption affect a TERA? 224.160 Section 224... Notice of Intent to Reassume § 224.160 How will reassumption affect a TERA? Reassumption of a TERA applies to all of the authority and activities assumed under a TERA. Upon reassumption, the tribe...

  1. Analysis of Radioactive Releases During Proposed Demolition Activities for the 224-U and 224-UA Buildings - Addendum

    Napier, Bruce A.; Rishel, Jeremy P.; Droppo, James G.; Joyce, Kevin E.; Strom, Daniel J.

    2010-12-21

    A post-demolition modeling analysis is conducted that compares during-demolition atmospheric concentration monitoring results with modeling results based on the actual meteorological conditions during the demolition activities. The 224-U and 224-UA Buildings that were located in the U-Plant UO3 complex in the 200 West Area of the Hanford Site were demolished during the summer of 2010. These facilities converted uranyl nitrate hexahydrate (UNH), a product of Hanford’s Plutonium-Uranium Extraction (PUREX) Plant, into uranium trioxide (UO3). This report is an addendum to a pre-demolition emission analysis and air dispersion modeling effort that was conducted for proposed demolition activities for these structures.

  2. Bedside etiology of childhood cancer. [X radiation, /sup 224/Ra

    Miller, R.W.

    1977-01-01

    The following topics are discussed: adenocarcinomas of the vagina in young women exposed prenatally to diethylstilbestrol; neuroblastoma in children exposed prenatally to hydantoin; increased frequency of leukemia in Japanese children surviving the atomic bomb; cancer in adults following administration of /sup 224/Ra during childhood; increased risk of lung cancer following environmental exposure of children to asbestos; lung cancer in adults following exposure to lead, copper, zinc, and arsenic; association of chromosomal aberrations with leukemia in children exposed to x radiation and benzene; immunosuppression in lymphoma patients; renal dysplasia in patients with Wilms' tumor; and aggregation of neoplasms in families. (HLW)

  3. Malignancies in patients treated with high doses of radium-224

    Nekolla, E.A. [Federal Office for Radiation Protection (BfS), Neuherberg (Germany); Walsh, L. [Radiobiological Inst., Univ. of Munich (Germany); Schottenhammer, G.; Spiess, H. [Children' s Hospital, Univ. of Munich (Germany)

    2005-07-01

    Several thousand German patients suffering from ankylosing spondylitis, tuberculosis and some other diseases, received multiple injections of the short-lived {alpha}-emitter {sup 224}Ra. The ''Spiess study'' was initiated in the early 1950s to follow the health of 899 persons (278 female, 621 male) who were treated mainly between 1945 and 1955. Most of the high dose patients and nearly all of those treated as children or juveniles (n=217) were included in the study. In June 2003, 152 persons were still alive. The most striking observed health effect, following {sup 224}Ra injections, was a temporal wave of 56 malignant bone tumours with a maximum at about 8 years after exposure which has already been described in several publications. In 2000, a new analysis was performed because an improved dosimetry resulted in modified bone surface doses. The estimated risk coefficient, averaged over all ages at exposure, was found to be in agreement with earlier analyses. However, a statistically significant increase of bone tumour risk with decreasing age at exposure was found. The earlier results, which indicated a reversed protraction factor, were confirmed. A significant excess of non-skeletal solid malignancies has also appeared during the most recent observation decade. In 2004, significant increases of cancer rates were observed for several sites: for breast cancer (31 cases observed vs. 9.1 cases expected), soft tissue malignancies (11 vs. 1.0), thyroid carcinomas (7 vs. 0.9), liver (8 vs. 2.3), kidney (13 vs. 4.6), pancreas (8 vs. 3.9), and bladder cancer (14 vs. 7.7). The 8-fold excess relative risk of mammary cancers in those women exposed as children or juveniles is particularly striking; moreover, 2 cases of breast cancer occurred in men. In 1993, a control group of tuberculosis patients not treated with {sup 224}Ra was established to rule out potential confounding factors - such as chest fluoroscopy - which might bias the breast cancer excess

  4. Clinical Research of Status Epilepticus: a report of 224 cases

    Qiang Tu

    2013-09-01

    Full Text Available Objective: To study the clinical efficacy of midazolam in the treatment of 224 patients with status epilepticus (SE. Methods: A total of 224 patients with status epilepticus (SE admitted in our hospital from October, 2010 to October, 2013 were selected and randomly divided into midazolam group (n = 144 and combination group (tranquillizer + phenobarbital (n = 80. 0.1 - 0.2 mg/ kg of midazolam were slowly given to midazolam group for 5 - 10 min while 0.3 - 0.5 mg/ kg of diazepam and 5 - 10 mg/kg of phenobarbital were intramuscularly injected to patients in combination group. Results: SE’s time was significantly controlled in midazolam group than in combination group, while it was suggested that SE children’s age, etiology, incentives, seizure type, EEG, imaging changes were independent with the short-term efficacy of SE patients (P > 0.05, and the duration of attack, treatment programs and short-term efficacy of SE were correlated (P < 0.05, according to the analysis of age, etiology, incentives, seizure type, duration of attack, laboratory examinations, the relationship between treatment and curative effect. Conclusion: Midazolam is a new BZDs drug containing some special advantages when compared with traditional ones, which is also a favorable anti-epileptic drug with high safety and reliability, rapid onset, simple application and mild toxic responses.

  5. Octupole collectivity in $^{220}$Rn and $^{224}$Ra

    Gaffney, Liam Paul

    Collective properties of the radioactive nuclei $^{220}$Rn and $^{224}$Ra have been studied via Coulomb excitation of a 2.8$\\,$A.MeV radioactive ion beam (RIB) incident upon $^{60}$Ni, $^{112,114}$Cd and $^{120}$Sn targets. The experiments took place at the REX-ISOLDE RIB facility, CERN. De-excitation $\\gamma$-ray yields following multiple-step Coulomb excitation were detected in coincidence with recoiling target nuclei in the Miniball spectrometer. For the first time, B(E3;3$^+ \\rightarrow 0^+$) values have been directly measured with a radioactive ion beam. In the process, $^{224}$Ra becomes the heaviest post-accelerated RIB to date at ISOLDE (with the possible exception of the quasi-stable $^{238}$U). The measurements presented in this thesis represent a tripling of the number of nuclei around Z$\\simeq88$ and N$\\simeq134$, for which direct measurements of the octupole collectivity have been performed. The only previous measurements being for the relatively long-lived $^{226}$Ra. The $\\gamma$-ray yields, in...

  6. Isolation and characterization of Bradyrhizobium sp. 224 capable of degrading sulfanilic acid.

    Hayase, Nobuki; Fujikawa, Yui; Nakagawa, Katsuhiko; Ushio, Kazutoshi

    2016-08-01

    A bacterial strain (strain 224), which has the ability to utilize sulfanilic acid as a sole source of carbon, was isolated from soil. 16S rRNA gene sequence obtained from strain 224 exhibited 100% identical to that of species in the genus Bradyrhizobium. Strain 224 degraded 4.7 mM of sulfanilic acid and released almost the same molar concentration of sulfate ion.

  7. Production of actinium, thorium and radium isotopes from natural thorium irradiated with protons up to 141 MeV

    Ermolaev, S.V.; Zhuikov, B.L.; Kokhanyuk, V.M.; Matushko, V.L. [Russian Academy of Sciences, Moscow (Russian Federation). Inst. of Nuclear Research; Kalmykov, S.N. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Chemistry Dept.; Aliev, R.A. [Lomonosov Moscow State Univ., Moscow (Russian Federation). Skobeltsyn Inst. of Nuclear Physics; Tananaev, I.G.; Myasoedov, B.F. [Russian Academy of Sciences, Moscow (Russian Federation). A.N. Frumkin Inst. of Physical Chemistry and Electrochemistry

    2012-07-01

    Cross sections of {sup 225}Ac, {sup 227}Ac, {sup 227}Th and {sup 228}Th in thorium-232 targets irradiated with protons in the energy range 21-141 MeV have been measured. Based on these data, production yields of {sup 225}Ac and {sup 223}Ra in thick thorium targets have been calculated. It is possible to produce in proton energy range 60-140 MeV about 96 GBq (2.6 Ci) {sup 225}Ac per 10-d irradiation with 100 {mu}A proton beam current and 10-d decay, and much higher amount of {sup 223}Ra. The impurities of {sup 227}Ac and {sup 224}Ra are important and need to be assessed for further medical applications. (orig.)

  8. The Complex Role of the ZNF224 Transcription Factor in Cancer.

    Cesaro, E; Sodaro, G; Montano, G; Grosso, M; Lupo, A; Costanzo, P

    2017-01-01

    ZNF224 is a member of the Kruppel-associated box zinc finger proteins (KRAB-ZFPs) family. It was originally identified as a transcriptional repressor involved in gene-specific silencing through the recruitment of the corepressor KAP1, chromatin-modifying activities, and the arginine methyltransferase PRMT5 on the promoter of its target genes. Recent findings indicate that ZNF224 can behave both as a tumor suppressor or an oncogene in different human cancers. The transcriptional regulatory properties of ZNF224 in these systems appear to be complex and influenced by specific sets of interactors. ZNF224 can also act as a transcription cofactor for other DNA-binding proteins. A role for ZNF224 in transcriptional activation has also emerged. Here, we review the state of the literature supporting both roles of ZNF224 in cancer. We also examine the functional activity of ZNF224 as a transcription factor and the influence of protein partners on its dual behavior. Increasing information on the mechanism through which ZNF224 can operate could lead to the identification of agents capable of modulating ZNF224 function, thus potentially paving the way to new therapeutic strategies for treatment of cancer.

  9. MiR-224 expression increases radiation sensitivity of glioblastoma cells

    Upraity, Shailendra; Kazi, Sadaf; Padul, Vijay; Shirsat, Neelam Vishwanath, E-mail: nshirsat@actrec.gov.in

    2014-05-30

    Highlights: • MiR-224 expression in established glioblastoma cell lines and sporadic tumor tissues is low. • Exogenous miR-224 expression was found to increase radiation sensitivity of glioblastoma cells. • MiR-224 expression brought about 55–60% reduction in API5 expression levels. • Transfection with API5 siRNA increased radiation sensitivity of glioblastoma cells. • Low miR-224 and high API5 expression correlated with worse survival of GBM patients. - Abstract: Glioblastoma (GBM) is the most common and highly aggressive primary malignant brain tumor. The intrinsic resistance of this brain tumor limits the efficacy of administered treatment like radiation therapy. In the present study, effect of miR-224 expression on growth characteristics of established GBM cell lines was analyzed. MiR-224 expression in the cell lines as well as in primary GBM tumor tissues was found to be low. Exogenous transient expression of miR-224 using either synthetic mimics or stable inducible expression using doxycycline inducible lentiviral vector carrying miR-224 gene, was found to bring about 30–55% reduction in clonogenic potential of U87 MG cells. MiR-224 expression reduced clonogenic potential of U87 MG cells by 85–90% on irradiation at a dose of 6 Gy, a dose that brought about 50% reduction in clonogenic potential in the absence of miR-224 expression. MiR-224 expression in glioblastoma cells resulted in 55–65% reduction in the expression levels of API5 gene, a known target of miR-224. Further, siRNA mediated down-regulation of API5 was also found to have radiation sensitizing effect on glioblastoma cell lines. Analysis of the Cancer Genome Atlas data showed lower miR-224 expression levels in male GBM patients to correlate with poorer survival. Higher expression levels of miR-224 target API5 also showed significant correlation with poorer survival of GBM patients. Up-regulation of miR-224 or down-regulation of its target API5 in combination with radiation therapy

  10. Upregulated microRNA-224 promotes ovarian cancer cell proliferation by targeting KLLN.

    Hu, Ke; Liang, Meng

    2017-02-01

    Human epithelial ovarian cancer is a complex disease, with low 5-yr survival rate largely due to the terminal stage at diagnosis in most patients. MicroRNAs play critical roles during epithelial ovarian cancer progression in vivo and have also been shown to regulate characteristic of ovarian cancer cell line in vitro. Alterative microRNA-224 (microRNA-224) expression affects human epithelial ovarian cancer cell survival, apoptosis, and metastasis. However, people know little about the effects of microRNA-224 on epithelial ovarian cancer cell proliferation. In the current study, we found that the microRNA-224 expression level of human syngeneic epithelial ovarian cancer cells HO8910 (low metastatic ability) was lower than that of HO8910PM (high metastatic ability). Furthermore, microRNA-224 was confirmed to target KLLN in HO8910 and HO8910PM. The known KLLN downstream target cyclin A was regulated by microRNA-224 in HO8910 and HO8910PM. In addition, overexpression of microRNA-224 enhanced the proliferation abilities of HO8910 and knockdown of microRNA-224 suppressed the proliferation abilities of HO8910PM by KLLN-cyclin A pathway. Our results provide new data about microRNAs and their targets involved in proliferation of epithelial ovarian cancer cells by modulating the downstream signaling.

  11. 78 FR 16757 - Twentieth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2013-03-18

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held April 4, 2013 from...

  12. 76 FR 59481 - Ninth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    2011-09-26

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems. SUMMARY: The FAA is issuing this notice to advise the public of a meeting of RTCA Special Committee 224: Airport Security Access Control...

  13. 78 FR 43963 - Twenty-Third Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2013-07-22

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held on June 20,...

  14. 77 FR 71474 - Seventeenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2012-11-30

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held December 13,...

  15. 77 FR 15448 - Twelfth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2012-03-15

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Notice of meeting RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... 224, Airport Security Access Control Systems DATES: The meeting will be held April 5, 2012, from 10...

  16. 78 FR 51810 - Twenty-Fourth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2013-08-21

    ... Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control... RTCA Special Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held...

  17. 78 FR 22025 - Twenty First Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2013-04-12

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held April 9-10,...

  18. 76 FR 50811 - Eighth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    2011-08-16

    ... Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems. SUMMARY: The FAA is issuing this notice to advise the public of a meeting of RTCA Special Committee 224: Airport Security Access Control...

  19. 77 FR 55894 - Fifteenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2012-09-11

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems DATES: The meeting will be held September 27-28,...

  20. 77 FR 25525 - Thirteenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems.

    2012-04-30

    ... Access Control Systems. AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems... Committee 224, Airport Security Access Control Systems DATES: The meeting will be held May 30, 2012, from...

  1. 77 FR 64838 - Sixteenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2012-10-23

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held November 15,...

  2. 78 FR 7850 - Nineteenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2013-02-04

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY... Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held February 21,...

  3. 50 CFR 224.104 - Special requirements for fishing activities to protect endangered sea turtles.

    2010-10-01

    ... activities to protect endangered sea turtles. 224.104 Section 224.104 Wildlife and Fisheries NATIONAL MARINE... endangered sea turtles. (a) Shrimp fishermen in the southeastern United States and the Gulf of Mexico who comply with rules for threatened sea turtles specified in § 223.206 of this chapter will not be...

  4. 42 CFR 457.224 - FFP: Conditions relating to cost sharing.

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false FFP: Conditions relating to cost sharing. 457.224... Claims; Reduction of Federal Medical Payments § 457.224 FFP: Conditions relating to cost sharing. (a) No FFP is available for the following amounts, even when related to services or benefit coverage which...

  5. 25 CFR 224.66 - How may a tribe reduce the scope of the TERA?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How may a tribe reduce the scope of the TERA? 224.66... Procedures for Obtaining Tribal Energy Resource Agreements Tera Requirements § 224.66 How may a tribe reduce the scope of the TERA? A tribe may reduce the scope of the TERA by negotiating with the Secretary...

  6. 25 CFR 224.173 - How does a tribe rescind a TERA?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does a tribe rescind a TERA? 224.173 Section 224.173... does a tribe rescind a TERA? To rescind a TERA, a tribe must submit to the Secretary a written tribal... TERA. Upon rescission, the tribe must also return all Departmental resources transferred under the...

  7. 25 CFR 224.74 - When must the Secretary approve or disapprove a final proposed TERA?

    2010-04-01

    ... proposed TERA? 224.74 Section 224.74 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY... disapprove a final proposed TERA? The Secretary must approve or disapprove a final proposed TERA or a revised final proposed TERA within 270 days of the Director's receipt of a complete application for a TERA....

  8. 25 CFR 224.52 - What may a tribe include in a TERA?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What may a tribe include in a TERA? 224.52 Section 224.52 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE... may a tribe include in a TERA? A TERA under this part: (a) May include development of all or part of...

  9. 25 CFR 224.53 - What must an application for a TERA contain?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What must an application for a TERA contain? 224.53... Application § 224.53 What must an application for a TERA contain? (a) An application for a TERA must contain all of the following: (1) A proposed TERA between the tribe and the Secretary, signed by...

  10. 22 CFR 224.45 - Deposit in Treasury of United States.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Deposit in Treasury of United States. 224.45... CIVIL REMEDIES ACT § 224.45 Deposit in Treasury of United States. All amounts collected pursuant to this part shall be deposited as miscellaneous receipts in the Treasury of the United States, except...

  11. 22 CFR 224.26 - Form, filing and service of papers.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Form, filing and service of papers. 224.26... CIVIL REMEDIES ACT § 224.26 Form, filing and service of papers. (a) Form. (1) Documents filed with the ALJ shall include an original and two copies. (2) Every pleading and paper filed in the...

  12. MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma

    Wang, Maomao; Deng, Xiaodong; Ying, Qi; Jin, Tingyan [The 411 Hospital of PLA, Department of Neurosurgery, 15 Dongjiangwan Road, Shanghai 200081 (China); Li, Ming [The 81 Hospital of PLA, Department of Neurosurgery, 34 Taiping Road, Nanjing 210002 (China); Liang, Chong, E-mail: liangchong1984@163.com [The 81 Hospital of PLA, Department of Neurosurgery, 34 Taiping Road, Nanjing 210002 (China)

    2015-05-01

    MicroRNA-224 is overexpressed in various malignant tumors with poor prognosis, which plays a critical role in biological processes including cell proliferation, apoptosis and several developmental and physiological progressions. However, the potential association between miR-224 and clinical outcome in patients with meningiomas remains unknown. Here, we investigate miR-224 expression and biological functions in meningiomas. MiR-224 expression was measured by Northern blot analysis and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in meningioma and normal brain tissues. Kaplan–Meier analysis and Cox regression analysis were used to exam its correlation with clinicopathological features and prognostic value. The biological effects of miR-224 on the cell proliferation and apoptosis in meningioma cells were examined by MTT assay and apoptosis assay. We found the expression levels of miR-224 were significantly higher in meningioma tissues than that in normal brain, positively correlated with advanced pathological grade. Kaplan–Meier analysis indicated that meningioma patients with low miR-224 expression exhibited significantly prolonged overall and recurrence-free survival. Furthermore, we demonstrated that ERG2 was an identical candidate target gene of MiR-224 in vitro. Our results indicated that downregulation of miR-224 suppressed cell growth and resulted in the enhancement of cell apoptosis through activation of the ERG2-BAK-induced apoptosis pathway. Our findings imply the miR-224 expression could predict the overall survival and recurrence-free survival of patients with meningioma and it might be a promising therapeutic target for treating malignant meningiomas. - Highlights: • MiR-224 expression is correlates with prognosis in meningioma patients. • ERG2 is a novel downstream target of miR-224. • MiR-224 suppressed cell growth and enhanced apoptosis in IOMM-Lee and CH157 cells. • MiR-224 is an upstream regulator of the ERG2

  13. MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma.

    Wang, Maomao; Deng, Xiaodong; Ying, Qi; Jin, Tingyan; Li, Ming; Liang, Chong

    2015-05-01

    MicroRNA-224 is overexpressed in various malignant tumors with poor prognosis, which plays a critical role in biological processes including cell proliferation, apoptosis and several developmental and physiological progressions. However, the potential association between miR-224 and clinical outcome in patients with meningiomas remains unknown. Here, we investigate miR-224 expression and biological functions in meningiomas. MiR-224 expression was measured by Northern blot analysis and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in meningioma and normal brain tissues. Kaplan-Meier analysis and Cox regression analysis were used to exam its correlation with clinicopathological features and prognostic value. The biological effects of miR-224 on the cell proliferation and apoptosis in meningioma cells were examined by MTT assay and apoptosis assay. We found the expression levels of miR-224 were significantly higher in meningioma tissues than that in normal brain, positively correlated with advanced pathological grade. Kaplan-Meier analysis indicated that meningioma patients with low miR-224 expression exhibited significantly prolonged overall and recurrence-free survival. Furthermore, we demonstrated that ERG2 was an identical candidate target gene of MiR-224 in vitro. Our results indicated that downregulation of miR-224 suppressed cell growth and resulted in the enhancement of cell apoptosis through activation of the ERG2-BAK-induced apoptosis pathway. Our findings imply the miR-224 expression could predict the overall survival and recurrence-free survival of patients with meningioma and it might be a promising therapeutic target for treating malignant meningiomas.

  14. 75 FR 45494 - Implementation of Section 224 of the Act; a National Broadband Plan for Our Future

    2010-08-03

    ... Doc. 2010-17048, the Commission seeks comment on additional considerations regarding boxing and... are unjust and unreasonable under section 224. 18. Section 224 also provides for the adoption of...

  15. MicroRNA-224 Suppresses Colorectal Cancer Cell Migration by Targeting Cdc42

    Tao-Wei Ke

    2014-01-01

    Full Text Available The metastatic spread of tumor cells is the major risk factor affecting the clinical prognosis of colorectal cancer (CRC patients. The metastatic phenotype can be modulated by dysregulating the synthesis of different structural and functional proteins of tumor cells. Micro(miRNAs are noncoding RNAs that recognize their cognate messenger (mRNA targets by sequence-specific interactions with the 3′ untranslated region and are involved in the multistep process of CRC development. The objective of this study was to investigate the expression and biological roles of miR-224 in CRC. The miR-224 expression level was assessed by a quantitative real-time PCR in 79 CRC and 18 nontumor tissues. Expression levels of miR-224 in CRC tissues were significantly lower than those in nontumor tissues. Its expression level was associated with the mutation status of the APC gene. Ectopic expression of miR-224 suppressed the migratory ability of CRC cell line, but cell proliferation was less affected. Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments. Overall, this study indicated a role of miR-224 in negatively regulating CRC cell migration. The expression level of miR-224 may be a useful predictive biomarker for CRC progression.

  16. 25 CFR 224.64 - How may a tribe assume management of development of different types of energy resources?

    2010-04-01

    ... Requirements § 224.64 How may a tribe assume management of development of different types of energy resources... 25 Indians 1 2010-04-01 2010-04-01 false How may a tribe assume management of development of different types of energy resources? 224.64 Section 224.64 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT...

  17. 25 CFR 224.87 - What are the obligations of a tribe if it discovers a violation or breach?

    2010-04-01

    ... violation or breach? 224.87 Section 224.87 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR... DETERMINATION ACT Implementation of Tribal Energy Resource Agreements Violation Or Breach § 224.87 What are the obligations of a tribe if it discovers a violation or breach? As soon as practicable after discovering...

  18. 25 CFR 224.117 - Must the Director make a determination of the tribe's compliance with a TERA?

    2010-04-01

    ... compliance with a TERA? 224.117 Section 224.117 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR... compliance with a TERA? (a) Yes. Upon a finding that one of the threshold determinations in § 224.115 has been met, the Director must make a determination of the tribe's compliance with a TERA within the...

  19. 22 CFR 224.39 - Appeal to A.I.D. Administrator.

    2010-04-01

    ... under § 224.38, consideration of the appeal shall be stayed automatically pending resolution of the... liable for a penalty or assessment to seek judicial review. (l) Unless a petition for review is filed as... judicial review....

  20. 22 CFR 224.16 - Disqualification of reviewing official or ALJ.

    2010-04-01

    ... PROGRAM FRAUD CIVIL REMEDIES ACT § 224.16 Disqualification of reviewing official or ALJ. (a) A reviewing... ALJ shall dismiss the complaint without prejudice. (2) If the ALJ disqualifies himself or herself,...

  1. 22 CFR 224.22 - Exchange of witness lists, statements, and exhibits.

    2010-04-01

    ... THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.22 Exchange of witness lists, statements, and exhibits. (a... there is no prejudice to the objecting party. (c) Unless another party objects within the time set...

  2. Autophagy-preferential degradation of MIR224 participates in hepatocellular carcinoma tumorigenesis.

    Lan, Sheng-Hui; Wu, Shan-Ying; Zuchini, Roberto; Lin, Xi-Zhang; Su, Ih-Jen; Tsai, Ting-Fen; Lin, Yen-Ju; Wu, Cheng-Tao; Liu, Hsiao-Sheng

    2014-09-01

    Autophagy and microRNA (miRNA) are important regulators during cancer cell tumorigenesis. Impaired autophagy and high expression of the oncogenic microRNA MIR224 are prevalent in hepatocellular carcinoma (HCC); however, the relationship between the 2 phenomena remains elusive. In this study, we are the first to reveal that autophagy selectively regulates MIR224 expression through an autophagosome-mediated degradation system. Based on this finding, we further demonstrated that in hepatitis B virus (HBV)-related HCC, aberrant autophagy (low autophagic activity) results in accumulation of MIR224 and decreased expression of the target gene Smad4, which leads to increased cell migration and tumor formation. Preferential recruitment of MIR224 into the autophagosome was clearly demonstrated by a) miRNA in situ hybridization under confocal microscopy, and b) immunogold labeling of MIR224 under electron microscopy compared with a ubiquitously expressed microRNA MIRlet7e/let-7. Furthermore, we found that off-label use of amiodarone, an antiarrhythmic agent, effectively suppressed HCC tumorigenesis through autophagy-mediated MIR224 degradation both in vitro and in vivo. In summary, we identified amiodarone as a new autophagy inducer, which may provide an alternative approach in HCC therapy through a novel tumor suppression mechanism.

  3. Long-term clinical investigation of patients with ankylosing spondylitis treated with /sup 224/Ra

    Schmitt, E. (Universitatsklinik Friedrichsheim, Frankfurt, West Germany); Ruckbeil, C.; Wick, R.R.

    1983-01-01

    Between 1952 and 1980 about 250 patients with ankylosing spondylitis were treated with /sup 224/Ra at the Orthopaedic University Hospital of Frankfurt/M. In 1970, 119 of them were examined and X-rayed as was another group of 40 patients in 1980. The results of those examined could be compared with a group of 40 patients treated without /sup 224/Ra. Patients with /sup 224/Ra demonstrated a long-lasting period of subjective improvement after the treatment, with reduced consumption of antirheumatoid and analgesic drugs, on the average. Blood examinations show inflammatory activities. Nevertheless, the ankylosing spondylitis proceeded. In the final stages of the disease, neither the clinical aspects nor the X-rays showed any specific changes. We observed no case of malignant bone tumor. Of the 169 examined patients, 22 had a total of 32 children after the treatment with /sup 224/Ra. Among these was a set of twins with cerebral palsy and diabetes insipidus renalis. In conclusion, /sup 224/Ra in ankylosing spondylitis is a recommended treatment without higher risk compared to the common therapy with drugs.

  4. EFFECT OF FK224 ON THE BRONCHOCONSTRICTION INDUCED BY ISOCAPNIC HYPERPNEA IN GUINEA PIGS

    陶梦非; 梁永杰

    2005-01-01

    Objective To evaluate effect of Neurokinin receptor antagonist on the prevention from hyperpnea-induced bronchoconstriction using a dual Neurokinin receptor antagonist FK224. Methods 12 pathogenfree Hartley guinea pigs were divided into two groups randomly: Dimethyl sulfoxide (DMSO) control group (n =6)and FK224 group (n =6). Guinea pigs were anesthetized with pentobarbital sodium. A cervical tracheostomy was performed and a polyethylene tube was inserted into the trachea. After measuring baseline value of the lung resistance (RL) and dynamic compliance of respiratory system (Cdyn) , DMSO (0. 3ml/kg) and FK224 ( 1mg/kg) were administered by injection through jugular vein respectively. A rodent respirator with dry 5% CO2-95% O2 mixture at room temperature provided mechanical ventilation ( VT 8ml/animal, 100breaths/min ) for 5min. RL and Cdyn of 2groups were measured after isocapnic hyperpnea challenge. Results In DMSO control group, isocapnic hyperpnea of dry gas elicited a marked increase in RL and decrease in Cdyn. RL and Cdyn of FK224 group did not change significantly. Conclusion FK224 can inhibit the increase in RL and decrease in Cdyn caused by isocapnic hyperpnea in guinea pigs. And antagonists of tachykinins receptors might have effect on prophylaxis and treatment in exercise-induced asthma.

  5. Late effects of radium-224 injected in children and adults survey and comment of a paediatrician

    Spiess, H. [Poliklinik Muenchen (Germany)

    2005-07-01

    Radium-224 (Ra-224) was already used as medicament before world war I; but because of serious side effects soon abandoned. It was revived as a remedy for tuberculosis and ankylosing spondylitis after world war II by a country doctor called Troch, supported by the Insurance Company ''Braunschweiger Landesversicherungsanstalt'' and over enthusiastic press reports. The 'new' medicine called 'Peteosthor' was a mixture of Ra-224 with traces of the red dye cosine and platinsol. The propaganda in favour of this therapy was so strong, that the government of Lower Saxony asked the University of Goettingen and others to examine this new 'wonderdrug'. Dr. Troch demanded that it should be used only under his personal supervision. As youngest assistent at the university childrens hospital of the University Goettingen I was sent in 1948 to this hospital in Hildesheim to examine 'Peteosthor'. (orig.)

  6. MicroRNA-224 inhibits proliferation and migration of breast cancer cells by down-regulating Fizzled 5 expression.

    Liu, Feng; Liu, Yang; Shen, Jingling; Zhang, Guoqiang; Han, Jiguang

    2016-08-02

    The Wnt/β-catenin signaling is crucial for the proliferation and migration of breast cancer cells. However, the expression of microRNA-224 (miR-224) in the different types of breast cancers and its role in the Wnt/β-catenin signaling and the proliferation and migration of breast cancer cells are poorly understood. In this study, the levels of miR-224 in different types of breast cancer tissues and cell lines were examined by quantitative RT-PCR and the potential targets of miR-224 in the Wnt/β-catenin signaling were investigated. The effects of altered miR-224 expression on the frequency of CD44+CD24- cancer stem-like cells (CSC), proliferation and migration of MCF-7 and MDA-MB-231 cells were examined by flow cytometry, MTT and transwell migration. We found that the levels of miR-224 expression in different types of breast cancer tissues and cell lines were associated inversely with aggressiveness of breast cancers. Enhanced miR-224 expression significantly reduced the fizzled 5-regulated luciferase activity in 293T cells, fizzled 5 expression in MCF-7 and MDA-MB-231 cells, the β-dependent luciferase activity in MCF-7 cells, and the nuclear translocation of β-catenin in MDA-MB-231 cells. miR-224 inhibition significantly increased the percentages of CSC in MCF-7 cells and enhanced proliferation and migration of MCF-7 cells. Enhanced miR-224 expression inhibited proliferation and migration of MDA-MB-231 cells, and the growth of implanted breast cancers in vivo. Induction of Frizzled 5 over-expression mitigated the miR-224-mediated inhibition of breast cancer cell proliferation. Collectively, these data indicated that miR-224 down-regulated the Wnt/β-catenin signaling possibly by binding to Frizzled 5 and inhibited proliferation and migration of breast cancer cells.

  7. Ra-224 and Ra-226: A New Method for Measuring Groundwater Seepage in Lake Michigan

    Stevens, K. R.; Buyan, A. C.; Waples, J. T.

    2008-12-01

    Radium isotopes have been used to estimate groundwater discharge (GWD) in coastal marine waters for decades, but this technique has never before been used in the Laurentian Great Lakes. In this study, we used a RAD7 radon-in-air monitor to measure naturally-occurring radium isotopes Ra-224 (half-life= 3.64 d) and Ra-226 (half-life = 1600 a) in groundwater and three shallow water sites along Lake Michigan's Wisconsin coastline. Radium-224 activities in groundwater ranged from 1153 dpm m-3 in a deep aquifer (New Berlin well no.7) to 31 dpm m-3 in a shallow aquifer (Pryor well). Nearshore Lake Michigan measurements of Ra-224 were lowest at Red Arrow Beach (0.2 dpm m-3), higher in the Milwaukee harbor (GLWI slip, 1.1 dpm m-3) and highest at Harrington Beach (4.1 dpm m-3) and correspond well with groundwater seepage estimates made by Cherkauer et al. (1990) using alternate methods (i.e., where higher radium activity is indicative of higher GWD). These Ra-224 measurements are the first ever made in Lake Michigan (and presumably any of the Great Lakes) and we conclude that, by sampling offshore radium activity gradients, this RAD7 technique is a viable method for directly measuring GWD in Lake Michigan and other freshwater systems.

  8. Cathepsin D (C224T) polymorphism in sporadic and genetic Creutzfeldt-Jakob disease.

    Kovacs, Gabor G; Sanchez-Juan, Pascual; Ströbel, Thomas; Schuur, Maaike; Poleggi, Anna; Nocentini, Sara; Giannattasio, Claudia; Belay, Girma; Bishop, Matthew; Capellari, Sabina; Parchi, Piero; Gelpi, Ellen; Gal, Aniko; Bakos, Agnes; Molnar, Maria J; Heinemann, Uta; Zerr, Inga; Knight, Richard S G; Mitrova, Eva; van Duijn, Cornelia; Budka, Herbert

    2010-01-01

    Accumulation of cathepsin D immunoreactive lysosomes correlates with tissue pathology in sporadic Creutzfeldt-Jakob disease (CJD) brains. The C-to-T transition within exon 2 of the cathepsin D (CTSD) gene is associated with altered enzymatic activity. Possession of the TT genotype is a risk factor for variant CJD. To verify the association between the CTSD position 224T allele and the risk for and survival in sporadic and genetic CJD, we genotyped 540 sporadic, 101 genetic CJD, and 723 control individuals. Genotype data and duration of illness were compared using multiple logistic regression and Kruskal-Wallis test. Multivariate survival analysis was performed using Cox's regression model. The distribution of CTSD position 224 alleles was approximately the same in all groups. We observed a trend for shorter survival in sporadic CJD patients harboring the T allele at position 224 of the CTSD gene in particular in sporadic CJD patients with the prion protein gene position 129 MM genotype. We conclude that the CTSD position 224 polymorphism alone is not a significant risk or disease-modifying factor in sporadic or genetic CJD.

  9. 76 FR 9632 - Fifth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    2011-02-18

    ... meeting: Airport Security Access Control Systems (Update to DO-230B). SUMMARY: The FAA is issuing this... Access Control Systems (Update to DO-230B): Agenda March 10, 2011 Welcome/Introductions/Administrative... Federal Aviation Administration Fifth Meeting: RTCA Special Committee 224: Airport Security Access...

  10. 75 FR 61819 - First Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    2010-10-06

    ... meeting: Airport Security Access Control Systems (Update to DO-230B). SUMMARY: The FAA is issuing this... Control Systems (Update to DO-230B): November 2, 2010 Welcome/Introductions/Administrative Remarks Agenda... Federal Aviation Administration First Meeting: RTCA Special Committee 224: Airport Security Access...

  11. 76 FR 16470 - Sixth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    2011-03-23

    ... meeting: Airport Security Access Control Systems (Update to DO-230B). SUMMARY: The FAA is issuing this... Control Systems (Update to DO-230B): Agenda April 13, 2011 Welcome/Introductions/Administrative Remarks... Federal Aviation Administration Sixth Meeting: RTCA Special Committee 224: Airport Security Access...

  12. 75 FR 80886 - Third Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    2010-12-23

    ... meeting: Airport Security Access Control Systems (Update to DO-230B). SUMMARY: The FAA is issuing this... Control Systems (Update to DO-230B): Agenda January 13, 2011 Welcome/Introductions/Administrative Remarks... Federal Aviation Administration Third Meeting: RTCA Special Committee 224: Airport Security Access...

  13. 76 FR 38742 - Seventh Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    2011-07-01

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to DO-230B). SUMMARY: The FAA is... Access Control Systems. DATES: The meeting will be held July 15, 2011, from 10 a.m. to 1 p.m....

  14. 76 FR 3931 - Fourth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    2011-01-21

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 Meeting: Airport Security Access Control Systems (Update to DO-230B). SUMMARY: The FAA is... Access Control Systems. DATES: The meeting will be held February 8, 2011, from 10 a.m. to 5...

  15. 75 FR 71790 - Second Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    2010-11-24

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to DO-230B). SUMMARY: The FAA is... Access Control Systems. DATES: The meeting will be held December 9, 2010, from 10 a.m. to 5...

  16. 77 FR 2343 - Eleventh Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    2012-01-17

    ... Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Notice of RTCA Special Committee 224, Airport Security Access Control Systems. SUMMARY: The FAA..., Airport Security Access Control Systems. DATES: The meeting will be held February 9, 2012, from 10...

  17. 33 CFR 157.224 - Dedicated Clean Ballast Tanks Operations Manual.

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Dedicated Clean Ballast Tanks... VESSELS CARRYING OIL IN BULK Dedicated Clean Ballast Tanks on Tank Vessels Design and Equipment § 157.224 Dedicated Clean Ballast Tanks Operations Manual. Each Dedicated Clean Ballast Tanks Operations Manual...

  18. 25 CFR 224.65 - How may a tribe assume additional activities under a TERA?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How may a tribe assume additional activities under a TERA... Procedures for Obtaining Tribal Energy Resource Agreements Tera Requirements § 224.65 How may a tribe assume additional activities under a TERA? A tribe may assume additional activities related to the development...

  19. 25 CFR 224.84 - When may a tribe grant a right-of-way?

    2010-04-01

    ... Tribal Energy Resource Agreements Leases, Business Agreements, and Rights-Of-Way Under A Tera § 224.84 When may a tribe grant a right-of-way? A tribe may grant a right-of-way under a TERA if the grant...

  20. 5 CFR 591.224 - How does OPM adjust price indexes between surveys?

    2010-01-01

    ... this, OPM uses the annual or biennial change in the Consumer Price Index (CPI) for the COLA area... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false How does OPM adjust price indexes between...-Of-Living Allowances § 591.224 How does OPM adjust price indexes between surveys? (a) OPM...

  1. 25 CFR 224.30 - What definitions apply to this part?

    2010-04-01

    ... Resources means both renewable and nonrenewable energy sources, including, but not limited to, natural gas... Provisions § 224.30 What definitions apply to this part? Act means the Indian Tribal Energy Development and... a TERA or activities under a TERA. Director means the Director of the Office of Indian Energy...

  2. 40 CFR 421.224 - Standards of performance for new sources.

    2010-07-01

    ... filtrate solvent extraction raffinate. NSPS for the Secondary Molybdenum and Vanadium Subcategory Pollutant... Molybdenum and Vanadium Subcategory § 421.224 Standards of performance for new sources. Any new source.... NSPS for the Secondary Molybdenum and Vanadium Subcategory Pollutant or pollutant property Maximum...

  3. Model for the induction of bone cancer by /sup 224/Ra. [In man

    Groer, P.G.; Marshall, J.H.

    1976-01-01

    A mathematical model for the transformation of normal endosteal cells into malignant tumor cells by ..cap alpha.. irradiation is applied to /sup 224/Ra. The model postulates that a normal endosteal cell near the bone surface is transformed into a malignant cell by three consecutive events. The first two events are the initiation events. The probability of their occurrence is proportional to the absorbed endosteal dose and they generate dormant tumor cells. These dormant tumor cells are promoted by the third event, the promotion event. The probability of this last event is proportional to the rate of bone remodeling but independent of the radiation dose. In competition with these transforming events is the killing of any endosteal cell by ..cap alpha.. irradiation. Killing is balanced by replacement of killed endosteal cells by normal stem cells. This model provides the following interesting predictions for the human /sup 224/Ra cases: after the decay of /sup 224/Ra the tumor rate decreases exponentially at a rate proportional to the bone turnover rate; for exposure to the same dose the model predicts an increased number of tumors for protracted exposure (i.e., exposure at a lower dose rate). Implications of this model for the therapy of ankylosing spondylitis are discussed. Statistical procedures are suggested for comparison of this theoretical model with the existing data on the induction of osteosarcomas by /sup 224/Ra in man.

  4. 18 CFR 367.2240 - Account 224, Other long-term debt.

    2010-04-01

    ... GAS ACT Balance Sheet Chart of Accounts Long-Term Debt § 367.2240 Account 224, Other long-term debt...-term debt. 367.2240 Section 367.2240 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY HOLDING COMPANY ACT OF...

  5. 25 CFR 224.102 - Must a tribe establish a comment or hearing process for addressing environmental concerns?

    2010-04-01

    ... addressing environmental concerns? 224.102 Section 224.102 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF... or hearing process for addressing environmental concerns? Yes. The Act (25 U.S.C. 3504(e)(2)(C)(iii... establish an environmental review process under a TERA that: (a) Ensures that the public is notified...

  6. 25 CFR 224.70 - Will the Secretary review a proposed TERA under the National Environmental Policy Act?

    2010-04-01

    ... National Environmental Policy Act? 224.70 Section 224.70 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF... Secretary review a proposed TERA under the National Environmental Policy Act? Yes, the Secretary will conduct a review under the National Environmental Policy Act (NEPA) of the potential impacts on...

  7. 25 CFR 224.41 - When does the Secretary require agreement of more than one tribe to approve a TERA?

    2010-04-01

    ... one tribe to approve a TERA? 224.41 Section 224.41 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... more than one tribe to approve a TERA? When tribal land held for the benefit of more than one tribe is contemplated for inclusion in a TERA, each appropriate tribal governing body must request a...

  8. 25 CFR 224.76 - Upon notification of disapproval, may a tribe re-submit a revised final proposed TERA?

    2010-04-01

    ... revised final proposed TERA? 224.76 Section 224.76 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... disapproval, may a tribe re-submit a revised final proposed TERA? Yes, within 45 days of receiving the notice...-submit a revised final proposed TERA, approved by the tribal governing body and signed by the...

  9. 25 CFR 224.75 - What must the Secretary do upon approval or disapproval of a final proposed TERA?

    2010-04-01

    ... of a final proposed TERA? 224.75 Section 224.75 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Secretary do upon approval or disapproval of a final proposed TERA? Within 10 days of the Secretary's approval or disapproval of a final proposed TERA, the Secretary must notify the tribal governing body...

  10. 25 CFR 224.67 - What must the Secretary do upon the Director's receipt of a final proposed TERA?

    2010-04-01

    ... a final proposed TERA? 224.67 Section 224.67 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... TERA? (a) Within 10 days of the Director's receipt of a final proposed TERA, the Secretary must submit... considering a final proposed TERA for approval or disapproval: and (2) Of any National Environmental...

  11. 25 CFR 224.71 - What standards will the Secretary use to decide to approve a final proposed TERA?

    2010-04-01

    ... approve a final proposed TERA? 224.71 Section 224.71 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... the Secretary use to decide to approve a final proposed TERA? The Secretary will consider the best... approve a final proposed TERA. The Secretary must approve a final proposed TERA if it contains...

  12. 25 CFR 224.82 - What activities will the Department continue to perform after approval of a TERA?

    2010-04-01

    ... after approval of a TERA? 224.82 Section 224.82 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... of a TERA? After approval of a TERA, the Department will provide a tribe: (a) All activities that the Department performs unless the tribe has assumed such activities under the TERA; (b) Access to title...

  13. 25 CFR 224.115 - When in the petition process must the Director investigate a tribe's compliance with a TERA?

    2010-04-01

    ... investigate a tribe's compliance with a TERA? 224.115 Section 224.115 Indians BUREAU OF INDIAN AFFAIRS... process must the Director investigate a tribe's compliance with a TERA? The Director must investigate the petitioner's claims of the tribe's noncompliance with a TERA only after making a threshold determination...

  14. Closure Report for Corrective Action Unit 224: Decon Pad and Septic Systems, Nevada Test Site, Nevada

    NSTec Environmental Restoration

    2007-10-01

    Corrective Action Unit (CAU) 224 is located in Areas 02, 03, 05, 06, 11, and 23 of the Nevada Test Site, which is situated approximately 65 miles northwest of Las Vegas, Nevada. CAU 224 is listed in the Federal Facility Agreement and Consent Order (FFACO) of 1996 as Decon Pad and Septic Systems and is comprised of the following nine Corrective Action Sites (CASs): CAS 02-04-01, Septic Tank (Buried); CAS 03-05-01, Leachfield; CAS 05-04-01, Septic Tanks (4)/Discharge Area; CAS 06-03-01, Sewage Lagoons (3); CAS 06-05-01, Leachfield; CAS 06-17-04, Decon Pad and Wastewater Catch; CAS 06-23-01, Decon Pad Discharge Piping; CAS 11-04-01, Sewage Lagoon; and CAS 23-05-02, Leachfield. The Nevada Division of Environmental Protection (NDEP)-approved corrective action alternative for CASs 02-04-01, 03-05-01, 06-03-01, 11-04-01, and 23-05-02 is no further action. As a best management practice, the septic tanks and distribution box were removed from CASs 02-04-01 and 11-04-01 and disposed of as hydrocarbon waste. The NDEP-approved correction action alternative for CASs 05-04-01, 06-05-01, 06-17-04, and 06-23-01 is clean closure. Closure activities for these CASs included removing and disposing of radiologically and pesticide-impacted soil and debris. CAU 224 was closed in accordance with the NDEP-approved CAU 224 Corrective Action Plan (CAP). The closure activities specified in the CAP were based on the recommendations presented in the CAU 224 Corrective Action Decision Document (U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, 2005). This Closure Report documents CAU 224 closure activities. During closure activities, approximately 60 cubic yards (yd3) of mixed waste in the form of soil and debris; approximately 70 yd{sup 3} of sanitary waste in the form of soil, liquid from septic tanks, and concrete debris; approximately 10 yd{sup 3} of hazardous waste in the form of pesticide-impacted soil; approximately 0.5 yd{sup 3} of universal waste in

  15. miR-224-3p inhibits autophagy in cervical cancer cells by targeting FIP200

    Fang, Wang; Shu, Shan; Yongmei, Li; Endong, Zhu; Lirong, Yin; Bei, Sun

    2016-01-01

    Cervical cancer (CC) is a malignant solid tumor, which is one of the main causes of morbidity and mortality in women. Persistent High-risk human papillomavirus (hrHPV) infection is closely related to cervical cancer and autophagy has been suggested to inhibit viral infections. miRNAs have been reported to regulate autophagy in many solid tumors with many studies implicating miR-224-3p in the regulation of autophagy. In this study, we performed a miRNA microarray analysis on CC tissues and found that a large number of miRNAs with differential expressions in hrHPV-infected tissues. We identified miR-224-3p as a candidate miRNA selectively up regulated in HPV-infected tissues and cell lines. Further analysis revealed that miR-224-3p regulates autophagy in cervical cancer tissues and cell lines. While the overexpression of miR-224-3p inhibits autophagy in HPV-infected cells, knocking down endogenous miR-224-3p increases autophagy activity in the same cells. In addition, we found that miR-224-3p directly inhibits the expression of autophagy related gene, FAK family-interacting protein of 200 kDa (FIP200). In summary, we found that miR-224-3p regulates autophagy in hrHPV-induced cervical cancer cells through targeting FIP200 expression. PMID:27615604

  16. Alkali activated materials state-of-the-art report, RILEM TC 224-AAM

    Deventer, Jannie

    2014-01-01

    This is a State of the Art Report resulting from the work of RILEM Technical Committee 224-AAM in the period 2007-2013. The Report summarises research to date in the area of alkali-activated binders and concretes, with a particular focus on the following areas: binder design and characterisation, durability testing, commercialisation, standardisation, and providing a historical context for this rapidly-growing research field.

  17. 25 CFR 224.88 - What must the Director do after receiving notice of a violation or breach from the tribe?

    2010-04-01

    ... violation or breach from the tribe? 224.88 Section 224.88 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF... DEVELOPMENT AND SELF DETERMINATION ACT Implementation of Tribal Energy Resource Agreements Violation Or Breach § 224.88 What must the Director do after receiving notice of a violation or breach from the tribe?...

  18. 25 CFR 224.89 - What procedures will the Secretary use to enforce leases, business agreements, or rights-of-way?

    2010-04-01

    ..., business agreements, or rights-of-way? 224.89 Section 224.89 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT... § 224.89 What procedures will the Secretary use to enforce leases, business agreements, or rights-of-way... assistance needed to enforce leases, business agreements, or rights-of-way entered into under a TERA....

  19. Functionalized NaA nanozeolites labeled with {sup 224,225}Ra for targeted alpha therapy

    Piotrowska, Agata, E-mail: a.kasperek@ichtj.waw.pl; Leszczuk, Edyta [Institute of Nuclear Chemistry and Technology (Poland); Bruchertseifer, Frank; Morgenstern, Alfred [Joint Research Centre – European Commission, Institute for Transuranium Elements (Germany); Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology (Poland)

    2013-11-15

    The {sup 223}Ra, {sup 224}Ra, and {sup 225}Ra radioisotopes exhibit very attractive nuclear properties for application in radionuclide therapy. Unfortunately the lack of appropriate bifunctional ligand for radium is the reason why these radionuclides have not found application in receptor-targeted therapy. In the present work, the potential usefulness of the NaA nanozeolite as a carrier for radium radionuclides has been studied. {sup 224}Ra and {sup 225}Ra, α-particle emitting radionuclides, have been absorbed in the nanometer-sized NaA zeolite (30–70 nm) through simple ion exchange. {sup 224,225}Ra-nanozeolites exhibited very high stability in solutions containing physiological salt, EDTA, amino acids, and human serum. To make NaA nanozeolite particles dispersed in water their surface was modified with a silane coupling agent containing poly(ethylene glycol) molecules. This functionalization approach let us covalently attach a biomolecule to the NaA nanozeolite surface.

  20. Analysis on incidence reason of 224 pulmonary tuberculosis patients%224例肺结核病人发病原因分析

    江秉态

    2013-01-01

    目的:探讨现阶段引起结核病发病的主要原因,为预防和控制结核病提供理论依据。方法:通过对旌阳区结核病防治所在2010年6月至2011年6月期间登记的224例新发涂阳肺结核病人进行回顾性问卷调查,对可能引起发病的原因进行分析。结果:224例肺结核病人中,有麻将史103例(46.0%),有网吧上网史38例(17.0%),有外出打工史20例(8.9%),有家人或同事患结核病14例(6.3%),同时有麻将史和打工史13例(5.8%),同时有麻将史和家庭接触史8例(3.6%),从事美容美发6例(2.6%),有在游戏厅玩游戏史的2例(0.9%),从事废品收购2例(0.9%),从事扫地工作1例(0.4%),其他17例(7.6%)。结论:在麻将馆打麻将和在网吧上网是目前引起结核病发病的主要原因,加强对麻将场馆和网吧等公共场所的监督与管理,并采取积极的干预措施势在必行。%Objective:To explore the main reason caused by tuberculosis at the present stage,to provide a theoretical basis for the prevention and control of tuberculosis. Methods:224 new smear-positive pulmonary tuberculosis patients who were registered during June 2010 to June 2011 in Jingyang District Tuberculosis Control Center were analyzed by retrospective questionnaires,to find the main reason of tuberculosis. Results:Among the 224 cases,103 cases with mahjong history(46.0%) ,38 cases with internet history (17.0%),20 cases with history of migrant workers(8.9%), 14 cases with family or colleagues suffering from tuberculosis(6.3%),13 cases with history of mahjong and migrant workers(5.8%),8 cases with history of mahjong and family or colleagues suffering from tuberculosis(3.6%), 8 cases with engaging in Beauty salon(2.6%),2 cases with history of playing games in the games room(0.9%),2 cases with engaging in the acquisition of waste(0.9%),1 case with engaging in sweeping work(0.4%), the other 17 cases(7

  1. The nursing on 224 cases of amniocentesis%羊膜腔穿刺术224例患者的护理

    张瑞女; 张礼婕; 雷桔红

    2010-01-01

    目的 探讨B超引导下羊膜腔穿刺术的术前、术中、术后的护理措施.方法 对224例行该手术的孕妇在术前、术中、术后各期进行相应的护理措施.结果 所有孕妇均能一次穿刺成功,无流产、感染等并发症.结论 B超引导下羊膜腔穿刺术是一种简便、安全、易行的检查方法,但细致、周到的护理是手术成功的重要保证.

  2. 25 CFR 224.152 - Must the Secretary always reassume the activities upon a finding of imminent jeopardy to a...

    2010-04-01

    ... TERA. (b) If the tribe does not respond to or does not comply with the Director's order under § 224.138(a)(3), the Secretary must immediately reassume all activities the tribe assumed under the TERA....

  3. Agent Based Manufacturing Capability Assessment in the Extended Enterprise Using Step AP224 and XML

    Ratchev, Svetan; Medani, Omar

    Data exchange in the extended enterprise is one of the most critical tasks in supporting collaborative decision-making. Companies often rely on geographically distributed suppliers for efficient product design and manufacture. Early design assessment can substantially reduce the cost of product development and production. This research proposes a new STEP AP224 EXPRESS based data model to facilitate the exchange of part and process data between distributed key agents in the early design process. The approach is illustrated using a prototype XML/CORBA environment to support the information exchange between collaborating design and manufacturing agents.

  4. 亿维发布UN CPU224 DC/DC/DC

    2011-01-01

    2011年12月.亿维(UniMAT)正式发布了UN CPU224DC/DC/DC.订货号为UN214-1AD23—0XB0。这是一款由亿维研发部根据多年PLC模块的市场经验.历时1年研发出来的200系列自主品牌PLC控制器模块.在兼容西门子PLC功能的前提下,做了部分优化及功能增强。

  5. 224例住院婴幼儿贫血病因分析%Analysis of the Cause of Anemia in 224 Cases of Infants and Young Children

    杨俊杰

    2015-01-01

    Objective To study the hospitalized infants and young children crowd in children with anemia, provide theoretical basis for the prevention and treatment of anemia in infants. Methods On 2010.8.1~2010.8.30 hospitalized in our department infant anemia investigation, to find the cause and fol ow-up. Results A total of 224 cases of infants and young children to complete fol ow-up. The most common etiology anemia is iron deficiency disease (69.4%), but 89.3% of them are mild, hemolytic anemia take second place, with favism is given priority to, and send out the Mediter anean anemia; Because of the repeated infection or third of anemia with other diseases. Conclusion Iron deficiency anemia is stil the infant anemia main reason, it is necessary to further strengthen the anemia prevention and control work.%目的探讨住院患儿中婴幼儿人群贫血原因,为防治婴幼儿贫血提供理论依据。方法对2010年8月1日~2013年8月30日在我科住院婴幼儿进行贫血调查,查找病因并进行随访。结果共224例婴幼儿完成随访。贫血病因以缺铁性病最常见(69.4%),但其中89.3%均为轻度表现,溶血性贫血次之,以蚕豆病为主,并有散发地中海贫血;因反复感染或伴随其它疾病的贫血占第3位。结论缺铁性贫血仍是婴幼儿贫血主要原因,有必要进一步加强对贫血防治工作。

  6. Bit Optimizing Experimental Study on Q2-24 Well%Q2-24井钻头优选试验研究

    陈波; 于文华; 文平; 陈志学

    2004-01-01

    玉门油田青西地区地层可钻性变化较大,钻头选型困难,导致机械钻速较低.在Q2-24井钻井过程中试验应用了BEST公司的PDC钻头和HUGHES公司的三牙轮钻头,结果表明:该地区弓形山组地层开始直到中沟组泥岩段(2200~3500m)夹杂砂岩、砾岩的地层,使用小尺寸、大倒角的PDC钻头是适宜的,但需认真分析岩性及井下情况,并参阅邻井PDC钻头使用资料,确定合理的钻井参数和钻具组合,以提高机械钻速,缩短钻井周期;与国产钻头相比,HUGHES钻头的的机械钻速较高,钻头的轴承和胎体材质较好,与国产钻头相比,能承受更大钻压.

  7. Clinical Research of Status Epilepticus:a report of 224 cases

    Tu Qiang; Huang Yi; Xiang Mingqing; Zhu Shaoliang; Ke Chengming; Li Fei

    2013-01-01

    Objective:To study the clinical efifcacy of midazolam in the treatment of 224 patients with status epilepticus (SE). Methods:A total of 224 patients with status epilepticus (SE) admitted in our hospital from October, 2010 to October, 2013 were selected and randomly divided into midazolam group (n = 144) and combination group (tranquillizer + phenobarbital) (n = 80). 0.1 ~ 0.2 mg/kg of midazolam were slowly given to midazolam group for 5 ~ 10 min while 0.3 ~ 0.5 mg/kg of diazepam and 5 ~ 10 mg/kg of phenobarbital were intramuscularly injected to patients in combination group. Results:SE’s time was signiifcantly controlled in midazolam group than in combination group, while it was suggested that SE children’s age, etiology, incentives, seizure type, EEG, imaging changes were independent with the short-term efficacy of SE patients (P > 0.05), and the duration of attack, treatment programs and short-term efifcacy of SE were correlated (P Conclusion:Midazolam is a new BZDs drug containing some special advantages when compared with traditional ones, which is also a favorable anti-epileptic drug with high safety and reliability, rapid onset, simple application and mild toxic responses.

  8. The segregation of starless and protostellar clumps in the Hi-GAL l=224deg region

    Olmi, L; Elia, D; Jones, P

    2016-01-01

    Stars form in dense, dusty structures, which are embedded in larger clumps of molecular clouds often showing a clear filamentary structure on large scales (> 1pc). One of the best-studied regions in the Hi-GAL survey can be observed toward the l=224deg field. Here, a filamentary region has been studied and it has been found that protostellar clumps are mostly located along the main filament, whereas starless clumps are detected off this filament and are instead found on secondary, less prominent filaments. We want to investigate this segregation effect and how it may affect the clumps properties. We mapped the 12CO(1-0) line and its main three isotopologues toward the two most prominent filaments observed toward the l=224deg field using the Mopra radio telescope, in order to set observational constraints on the dynamics of these structures and the associated starless and protostellar clumps. Compared to the starless clumps, the protostellar clumps are more luminous, more turbulent and lie in regions where the...

  9. Microscopic study of positive-parity yrast bands of 224−234Th isotopes

    Daya Ram; Rani Devi; S K Khosa

    2013-06-01

    The positive-parity bands in 224−234Th are studied using the projected shell model (PSM) approach. The energy levels, deformation systematics, (2) transition probabilities and nuclear -factors are calculated and compared with the experimental data. The calculation reproduces the observed positive-parity yrast bands and (2) transition probabilities. Measurement of (2) transition probabilities for higher spins and -factors would be a stringent test for our predictions. The results of theoretical calculations indicate that the deformation systematics in 224−234Th isotopes depend on the occupation of low components of high j orbits in the valence space and the deformation producing tendency of the neutron–proton interaction operating between spin orbit partner (SOP) orbits, the $[(2g_{9/2}_{}) - (2g_{7/2})_{}]$ and $[(1i_{13/2})_{} - (1i_{11/2})_{}]$ SOP orbits in the present context. In addition, the deformation systematics also depend on the polarization of $(1h_{11/2})_{}$ orbit. The low-lying states of yrast spectra are found to arise from 0-quasiparticle (qp) intrinsic states whereas the high-spin states turn out to possess composite structure.

  10. Long term investigation of late effects in ankylosing spondylitis patients treated with radium-224

    Wick, R.R. [GSF - National Research Center for Environment and Health, Inst. of Radiobiology, Neuherberg (Germany); Nekolla, E.A. [Federal Office for Radiation Protection (BfS), Neuherberg (Germany)

    2005-07-01

    An epidemiological study has been carried out on 1462 ankylosing spondylitis (AS) patients followed since 1971 at the GSF - National Research Center for Environment and Health. The aim of the study was to ascertain the late health effects occurring in these patients who had received repeated intravenous injections of the short lived {alpha}-emitter {sup 224}radium between 1948 and 1975 (excluding patients treated additionally with X-rays). The then usual therapeutic protocol consisted of a total of 10 to 12 injections of 1.036 MBq (28 {mu}Ci) of {sup 224}Ra each, given at weekly intervals. This resulted in a cumulative {alpha}-dose of 0.56 to 0.67 Gy to the marrow-free skeleton (bone surface dose: {proportional_to} 5.5 Gy) of a 70-kg-man (standard man). These patients have been followed together with a control group of 1324 ankylosing spondylitis patients not treated with radioactive drugs and/or X-rays. Up to August 2004, causes of death have been ascertained for 913 exposed patients and 971 controls (mean follow-up time {proportional_to} 26 yr in the exposed group or {proportional_to} 24 yr in the control group). In the exposed group there has been a total of 251 malignant diseases (vs. 277.0 expected cases) and 233 cases (vs. 302.4 exp.) among the controls. In the exposure group 16 cases of kidney cancer (vs. 8.7 cases expected, p = 0.02), 6 cases of liver cancer (vs. 3.3 exp., p = 0.12), and 4 cases of thyroid cancer (vs. 1.1 exp., p = 0.03) were observed. The most striking observation, however, were the 16 cases of leukaemia in the exposure group (vs. 6.5 cases expected, p = 0.001) compared to only 10 cases of leukaemia in the control group (vs. 7.1 cases expected, p = 0.2). Further subclassification of the leukaemias demonstrated a high increase of myeloid leukaemia in the exposure group (10 cases obs. vs. 2.8 cases exp., p <0.001), and particularly, of myeloid leukaemia (7 cases observed vs. 1.7 expected, p = 0.002), whereas in the control group the number

  11. Clinical analysis on continuous epidural labor analgesia in 224 cases%224例连续硬膜外分娩镇痛临床分析

    李思会; 高启俊

    2014-01-01

    Objective To explore the effect of continuous epidural labor analgesia and its impact on pregnancy outcome. Method A to-tal of 224 primiparous women receiving continuous epidural labor analgesia voluntarily were selected as study group;250 primiparous women not receiving continuous epidural labor analgesia during the same period were randomly selected as control group;the analgesic effects and pregnancy outcomes in the two groups were compared. Results VAS score in study group was significantly lower than that in control group;the incidence rate of uterine inertia during stages of labor in study group was significantly higher than that in control group;the duration time of the first stage of labor,the duration time of the second stage of labor,the total duration time of stages of labor in study group were signifi-cantly higher than those in control group;the rate of lateral episiotomy in study group was significantly lower than that in control group,there were statistically significant differences in the above-mentioned indexes between the two groups( P﹤0. 005 );there was no statistically significant difference in the incidence rates of cesarean section,surgical midwifery,postpartum hemorrhage,and neonatal asphyxia between the two groups(P>0. 05). Conclusion The effect of continuous epidural labor analgesia is good,the method can reduce the harms of deliv-ery to pregnant women and their babies,the safety is high,so the method is worthy to be popularized extensively.%目的:探讨连续硬膜外分娩镇痛的镇痛效果及对妊娠结局的影响。方法:选取自愿接受并实行连续硬膜外分娩镇痛的224例初产妇为研究组,随机选取同期不采用分娩镇痛的初产妇250例为对照组,比较分析两组镇痛效果及妊娠结局。结果:镇痛组的视觉模拟标尺( VAS)法评分明显低于对照组,产程中宫缩乏力的发生率高于对照组,的第一产程、第二产程、总产程时长高于对照组,会

  12. Synthesis, characterisation, stereochemistry and antimicrobial activity of 5 -piperazino- and 5-morpholinoacetyl-2,2,4-trimethyl-1, 5-benzodiazepines

    S Ponnuswamy; A Akila; D Deepa Rajakumari; V Shreevidhyaa Suressh; G Usha

    2015-11-01

    Three 1,5-benzodiazepines viz., 5-chloroacetyl-, 5-piperazinoacetyl- and N5 -morpholinoacetyl-2,2,4-trimethyl-1H-1,5-benzodiazepines have been synthesized. The structural characterisation and the conformational preferences of the compounds have been carried out using IR, 1D and 2D NMR spectral data. The NMR spectral data show that the -acetyltetrahydro-1,5-benzodiazepines prefer to exist in boat conformation with exo orientation of >C=O at 5 position in the solution state. The X-ray crystal structure of 5-morpholinoacetyl-2,2,4-trimethyl-1H-1,5-benzodiazepine also supports boat conformation in the solid state. The antimicrobial activity for -acetyltetrahydro-1,5-benzodiazepines have been carried out. -morpholinoacetyl-2,2,4-trimethyl-1H-1,5-benzodiazepine demonstrated better antibacterial and antifungal activities.

  13. A scanning electron microscopy study of the macro-crystalline structure of 2-(2,4-dinitrobenzyl) pyridine

    Ware, Jacqueline; Hammond, Ernest C., Jr.

    1989-01-01

    The compound, 2-(2,4-dinitrobenzyl) pyridine, was synthesized in the laboratory; an introductory level electron microscopy study of the macro-crystalline structure was conducted using the scanning electron microscope (SEM). The structure of these crystals was compared with the macrostructure of the crystal of 2-(2,4-dinitrobenzyl) pyridinium bromide, the hydrobromic salt of the compound which was also synthesized in the laboratory. A scanning electron microscopy crystal study was combined with a study of the principle of the electron microscope.

  14. Low-Lying Collective Levels in 224-234 Th Nuclei

    Diab S. M.

    2008-04-01

    Full Text Available The low-lying collective levels in 224-234 Th isotopes are investigated in the frame work of the interacting boson approximation model (IBA-1. The contour plot of the potential energy surfaces, V(beta,gamma, shows two wells on the prolate and oblate sides which indicate that all thorium nuclei are deformed and have rotational characters. The levels energy, electromagnetic transition rates B(E1 and B(E2 are calculated. Bending at angular momentum $I^+ = 20$ has been observed for 230 Th. Staggering effect has been calculated and beat patterns are obtained which indicate the existence of an interaction between the ground state band, (GSB, and the octupole negative parity band, (NPB. All calculated values are compared with the available experimental data and show reasonable agreement.

  15. Theoretical stusy of the reaction between 2,2',4' - trihydroxyazobenzene-5-sulfonic acid and zirconium

    Fletcher, Mary H.

    1960-01-01

    Zirconium reacts with 2,2',4'-trihydroxyazobenzene-5-sulfonic acid in acid solutions to Form two complexes in which the ratios of dye to zirconium are 1 to 1 and 2 to 1. Both complexes are true chelates, with zirconium acting as a bridge between the two orthohydroxy dye groups. Apparent equilibrium constants for the reactions to form each of the complexes are determined. The reactions are used as a basis for the determination of the active component in the dye and a graphical method for the determination of reagent purity is described. Four absorption spectra covering the wave length region from 350 to 750 mu are given, which completely define the color system associated with the reactions in solutions where the hydrochloric acid concentration ranges from 0.0064N to about 7N.

  16. 浅析西门子CPU224CN与smart700触摸屏的通信设置%Analysis of Siemens CPU224CN and Smart700 Touch Screen-based Communication Settings

    廖世海; 夏路生; 贾彬

    2013-01-01

    In this paper,Siem ens S7-200PLC (C PU 224C N ) and sm art700 com poses three conveyor control system as an exam ple,Siem ens S7-200 (C PU 224C N ) com m unication w ith the Siem ens sm art700 touch screen set-tings,and com m unication m ay encounterproblem sare introduced.Forinitialusing touch screen w orkersitisvery helpful.%  本文以西门子S7-200PLC(C PU 224C N)和sm art700组成的三条传送带控制系统为例,介绍了西门子S7-200(C PU 224C N )与西门子sm art700触摸屏之间的通信设置以及通信时可能会遇到的问题。这对于初次使用这种触摸屏做工程的人来说,帮助非常大。

  17. 40 CFR 22.4 - Powers and duties of the Environmental Appeals Board, Regional Judicial Officer and Presiding...

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Powers and duties of the Environmental.../TERMINATION OR SUSPENSION OF PERMITS General § 22.4 Powers and duties of the Environmental Appeals Board... disqualified, the Regional Administrator from the Region where the case originated shall replace...

  18. 25 CFR 224.86 - Are there limits on the duration of leases, business agreements, and rights-of-way?

    2010-04-01

    ... Agreements, and Rights-Of-Way Under A Tera § 224.86 Are there limits on the duration of leases, business agreements, and rights-of-way? (a) The duration of leases, business agreements, and rights-of-way entered...) For rights-of-way, 30 years. (b) A lease or business agreement a tribe enters into, or a...

  19. Acute Inhalation of 2,2,4-Trimethylpentane Alters Visual Evoked Potentials and Signal Detection Behavior in Rats

    The volatile organic compound 2,2,4-trimethylpentane (TMP, "isooctane") is a constituent of gasoline for which the current health effects data are insufficient to permit the US Environmental Protection Agency to conduct a risk assessment. The potential neurological impairment fro...

  20. Acute inhalation of 2,2,4-trimethylpentane alters visual evoked potentials and signal detection behaviour of rats.

    The volatile organic compound 2,2,4-trimethylpentane (TMP, “isooctane”) is a primary constituent of gasoline for which the current health effects data are insufficient to permit EPA to conduct a risk assessment. We evaluated potential neurological impairment from acute inhalati...

  1. 25 CFR 224.120 - What action may the Director take to ensure compliance with a TERA?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What action may the Director take to ensure compliance... DETERMINATION ACT Interested Party Petitions § 224.120 What action may the Director take to ensure compliance... take action to ensure compliance with the TERA including: (a) Temporarily suspending any activity...

  2. 25 CFR 224.104 - Must a tribe enact tribal laws, regulations, or procedures permitting a person or entity to...

    2010-04-01

    ... procedures permitting a person or entity to allege that a tribe is not complying with a TERA? 224.104 Section... to allege that a tribe is not complying with a TERA? No. A tribe is not required, but may elect, to... party to allege that a tribe is not complying with its TERA....

  3. 25 CFR 224.40 - How does the Act or a TERA affect the Secretary's trust responsibility?

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does the Act or a TERA affect the Secretary's trust... DETERMINATION ACT General Provisions § 224.40 How does the Act or a TERA affect the Secretary's trust..., business agreement, or right-of-way executed under an approved TERA violates any term of the...

  4. 25 CFR 224.55 - Is information a tribe submits throughout the TERA process under this part subject to disclosure...

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Is information a tribe submits throughout the TERA... Resource Agreements Processing Applications § 224.55 Is information a tribe submits throughout the TERA...) Information a tribe submits to the Department throughout the TERA process under this part may be subject...

  5. 25 CFR 224.116 - What is the time period in which the Director must investigate a tribe's compliance with a TERA?

    2010-04-01

    ... investigate a tribe's compliance with a TERA? 224.116 Section 224.116 Indians BUREAU OF INDIAN AFFAIRS... period in which the Director must investigate a tribe's compliance with a TERA? (a) If the Director... is in compliance with the TERA; (b) The Director may extend the time for determining a...

  6. 25 CFR 224.77 - Who may appeal the Secretary's decision on a final proposed TERA or a revised final proposed TERA?

    2010-04-01

    ... proposed TERA or a revised final proposed TERA? 224.77 Section 224.77 Indians BUREAU OF INDIAN AFFAIRS... may appeal the Secretary's decision on a final proposed TERA or a revised final proposed TERA? Only a tribe applying for a TERA may appeal the Secretary's decision to disapprove a final proposed TERA or...

  7. 25 CFR 224.100 - May a person or entity ask the Secretary to review a tribe's compliance with a TERA?

    2010-04-01

    ... tribe's compliance with a TERA? 224.100 Section 224.100 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF... Secretary to review a tribe's compliance with a TERA? In accordance with this subpart, a person or entity... with a TERA. However, before filing a petition with the Secretary, a person or entity that may be...

  8. 25 CFR 224.172 - May a tribe rescind only some of the activities subject to a TERA while retaining a portion of...

    2010-04-01

    ... to a TERA while retaining a portion of those activities? 224.172 Section 224.172 Indians BUREAU OF... rescind only some of the activities subject to a TERA while retaining a portion of those activities? No. A tribe may only rescind a TERA in its entirety, including the authority to approve leases,...

  9. 25 CFR 224.105 - How may a person or entity obtain copies of tribal laws, regulations, or procedures that would...

    2010-04-01

    ..., regulations, or procedures that would permit an allegation of noncompliance with a TERA? 224.105 Section 224... would permit an allegation of noncompliance with a TERA? (a) A person or entity that may be an... that permit a person or entity to allege that the tribe is not complying with its TERA by making...

  10. Population of 224 realistic human subject-based computational breast phantoms

    Erickson, David W. [Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States); Wells, Jered R., E-mail: jered.wells@duke.edu [Clinical Imaging Physics Group and Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States); Sturgeon, Gregory M. [Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 (United States); Samei, Ehsan [Department of Radiology and Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 and Departments of Physics, Electrical and Computer Engineering, and Biomedical Engineering, and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States); Dobbins, James T. [Department of Radiology and Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 and Departments of Physics and Biomedical Engineering and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States); Segars, W. Paul [Department of Radiology and Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States); Lo, Joseph Y. [Department of Radiology and Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 and Departments of Electrical and Computer Engineering and Biomedical Engineering and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States)

    2016-01-15

    Purpose: To create a database of highly realistic and anatomically variable 3D virtual breast phantoms based on dedicated breast computed tomography (bCT) data. Methods: A tissue classification and segmentation algorithm was used to create realistic and detailed 3D computational breast phantoms based on 230 + dedicated bCT datasets from normal human subjects. The breast volume was identified using a coarse three-class fuzzy C-means segmentation algorithm which accounted for and removed motion blur at the breast periphery. Noise in the bCT data was reduced through application of a postreconstruction 3D bilateral filter. A 3D adipose nonuniformity (bias field) correction was then applied followed by glandular segmentation using a 3D bias-corrected fuzzy C-means algorithm. Multiple tissue classes were defined including skin, adipose, and several fractional glandular densities. Following segmentation, a skin mask was produced which preserved the interdigitated skin, adipose, and glandular boundaries of the skin interior. Finally, surface modeling was used to produce digital phantoms with methods complementary to the XCAT suite of digital human phantoms. Results: After rejecting some datasets due to artifacts, 224 virtual breast phantoms were created which emulate the complex breast parenchyma of actual human subjects. The volume breast density (with skin) ranged from 5.5% to 66.3% with a mean value of 25.3% ± 13.2%. Breast volumes ranged from 25.0 to 2099.6 ml with a mean value of 716.3 ± 386.5 ml. Three breast phantoms were selected for imaging with digital compression (using finite element modeling) and simple ray-tracing, and the results show promise in their potential to produce realistic simulated mammograms. Conclusions: This work provides a new population of 224 breast phantoms based on in vivo bCT data for imaging research. Compared to previous studies based on only a few prototype cases, this dataset provides a rich source of new cases spanning a wide range

  11. The segregation of starless and protostellar clumps in the Hi-GAL ℓ = 224° region

    Olmi, L.; Cunningham, M.; Elia, D.; Jones, P.

    2016-10-01

    Context. Stars form in dense, dusty structures, which are embedded in larger clumps of molecular clouds often showing a clear filamentary structure on large scales (≳1 pc). The origin (e.g., turbulence or gravitational instabilities) and evolution of these filaments, as well as their relation to clump and core formation, are not yet fully understood. A large sample of both starless and protostellar clumps can now be found in the Herschel Infrared GALactic Plane Survey (Hi-GAL) key project, which also provides striking images of the filamentary structure of the parent molecular clouds. Recent results indicate that populations of clumps on and off filaments may differ. Aims: One of the best-studied regions in the Hi-GAL survey can be observed toward the ℓ = 224° field. Here, a filamentary region has been studied and it has been found that protostellar clumps are mostly located along the main filament, whereas starless clumps are detected off this filament and are instead found on secondary, less prominent filaments. We want to investigate this segregation effect and how it may affect the clumps properties. Methods: We mapped the 12CO (1-0) line and its main three isotopologues toward the two most prominent filaments observed toward the ℓ = 224° field using the Mopra radio telescope, in order to set observational constraints on the dynamics of these structures and the associated starless and protostellar clumps. Results: Compared to the starless clumps, the protostellar clumps are more luminous, more turbulent and lie in regions where the filamentary ambient gas shows larger linewidths. We see evidence of gas flowing along the main filament, but we do not find any signs of accretion flow from the filament onto the Hi-GAL clumps. We analyze the radial column density profile of the filaments and their gravitational stability. Conclusions: The more massive and highly fragmented main filament appears to be thermally supercritical and gravitationally bound

  12. Determination of {sup 226}Ra and {sup 224}Ra in sediments samples by liquid scintillation counting

    Villa, M. [Facultad de Fisica. Av. Reina Mercedes s/n, apdo 1065, Departamento de Fisica Atomica, Molecular y Nuclear, Universidad de Sevilla, 41080-Sevilla (Spain)]. E-mail: mvilla@us.es; Moreno, H.P. [E.T.S. Arquitectura. Av. Reina Mercedes, 2, Departamento de Fisica Aplicada II, Universidad de Sevilla, 41012-Sevilla (Spain); Manjon, G. [E.T.S. Arquitectura. Av. Reina Mercedes, 2, Departamento de Fisica Aplicada II, Universidad de Sevilla, 41012-Sevilla (Spain)

    2005-10-01

    An experimental procedure has been developed for a rapid determination of the activity concentration of {sup 226}Ra and {sup 224}Ra in sediments by liquid scintillation counting. The importance of the method lies in its application to the measurement of sediments where the Ra-isotopes activity concentration has been increased due to an anthropomorphic enhancement based on releases of naturally occurring radioactive material (NORM). A sample pre-treatment, including a digestion with aqua regia and a precipitation of hydroxides, was applied to samples before the radium extraction, which was made by co-precipitation with barium. Measurements were done in a low background scintillation spectrometer Quantulus 1220, which can separate and detect simultaneously {alpha} and {beta} particles. Additionally, some improvements are suggested for a better {alpha} and {beta} interference correction of the results. The obtaining of radiochemical yields is also improved using {sup 133}Ba as tracer, which decays by emission of conversion electrons and {gamma}-rays; the wide range of radiochemical yields obtained confirms the need of this analyses. The procedure has been applied to the measurement of riverbed sediments from an estuary in the south-west of Spain, affected in the past by direct and indirect phosphogypsum discharges.

  13. Alpha decay of {sup 184-224}Bi isotopes from the ground state and isomeric state

    Santhosh, K.P.; Priyanka, B. [Kannur University, School of Pure and Applied Physics, Kerala (India)

    2013-12-15

    The {alpha} -decay half-lives for the favored and unfavored transitions of the isotopes of Bi (Z = 83) nuclei in the region 184 {<=}A {<=} 224, from both the ground state (g.s.) and the isomeric state (i.s.) have been studied systematically within the Coulomb and proximity potential model (CPPM). The half-lives have been evaluated using the experimental Q-values. The computed half-lives are compared with the experimental data and they are in good agreement. We have modified the assault frequency and redetermined the half-lives and they show a better agreement with the experimental value. The standard deviation of the logarithm of the half-life with the former assault frequency is found to be 1.234 and with the modified assault frequency, it is found to be 0.935. This reveals that the CPPM, with the modified deformation-dependent assault frequency is more apt for the alpha-decay studies. Using our model we could also demonstrate the influence of the N = 126, neutron shell closure in both parent and daughter nuclei on the alpha-decay half-lives. (orig.)

  14. The Properties of H{\\alpha} Emission-Line Galaxies at $z$ = 2.24

    An, F X; Wang, W -H; Huang, J -S; Kong, X; Wang, J -X; Fang, G W; Zhu, F; Gu, Q -S; Wu, H; Hao, L; Xia, X -Y

    2014-01-01

    Using deep narrow-band $H_2S1$ and $K_{s}$-band imaging data obtained with CFHT/WIRCam, we identify a sample of 56 H$\\alpha$ emission-line galaxies (ELGs) at $z=2.24$ with the 5$\\sigma$ depths of $H_2S1=22.8$ and $K_{s}=24.8$ (AB) over 383 arcmin$^{2}$ area in the ECDFS. A detailed analysis is carried out with existing multi-wavelength data in this field. Three of the 56 H$\\alpha$ ELGs are detected in Chandra 4 Ms X-ray observation and two of them are classified as AGNs. The rest-frame UV and optical morphologies revealed by HST/ACS and WFC3 deep images show that nearly half of the H$\\alpha$ ELGs are either merging systems or with a close companion, indicating that the merging/interacting processes play a key role in regulating star formation at cosmic epoch z=2-3; About 14% are too faint to be resolved in the rest-frame UV morphology due to high dust extinction. We estimate dust extinction form SEDs. We find that dust extinction is generally correlated with H$\\alpha$ luminosity and stellar mass (SM). Our res...

  15. Using 224Ra/228Th disequilibrium to quantify benthic fluxes of dissolved inorganic carbon and nutrients into the Pearl River Estuary

    Cai, Pinghe; Shi, Xiangming; Hong, Qingquan; Li, Qing; Liu, Lingfeng; Guo, Xianghui; Dai, Minhan

    2015-12-01

    The 224Ra/228Th disequilibrium that was recently observed in coastal sediments has been proven to be an excellent proxy for tracing the benthic processes that regulate solute transfer across the sediment-water interface. In order to better utilize this proxy, there is a need to understand the reaction kinetics of 224Ra in sediments. In this study, depth profiles of 224Ra and 228Th in bulk sediments were collected along a transect in the Pearl River Estuary (PRE). Together with bulk sediment measurements, dissolved 224Ra, dissolved inorganic carbon (DIC), and nutrients (NO2- + NO3-, NH4+) in pore water and in the overlying waters were also determined. A marked deficit of 224Ra with respect to 228Th with large spatial variations was observed in the PRE sediments. By use of a diagenetic model for the distributions of dissolved and adsorbed 224Ra in sediments, we infer that adsorption removes 224Ra from aqueous phase at a rate of 0.1 ± 1.1-2000 ± 400 d-1. In addition, adsorption of 224Ra exhibits a rate sequence of oxic freshwater > anoxic freshwater > anoxic brackish water, probably reflecting the effect of the redox conditions and ionic strength on the adsorption-desorption kinetics of 224Ra. Benthic fluxes of 224Ra were estimated from the observed deficit of 224Ra in the sediments using a one-dimensional (1D) mass balance exchange model. We demonstrated that irrigation was the predominant process that controls solute transfer across the sediment-water interface, whereas molecular diffusion and sediment mixing together contributed <5% of the total 224Ra fluxes from bottom sediments. We then utilized the 224Ra/228Th disequilibrium approach to quantify the benthic fluxes of DIC and nutrients. We showed that sediment interstitial waters delivered approximately 42 ± 6 × 109 mol of DIC and ˜16 ± 1 × 109 mol of NH4+ into the PRE in the dry season. In contrast, it removed about 13 ± 1 × 109 mol of NO3- from the overlying water column. The benthic flux of DIC is

  16. Do nuclei go pear-shaped? Coulomb excitation of 220Rn and 224Ra at REX-ISOLDE (CERN

    Scheck M.

    2015-01-01

    Full Text Available The IS475 collaboration conducted Coulomb-excitation experiments with post-accelerated radioactive 220Rn and 224Ra beams at the REX-ISOLDE facility. The beam particles (Ebeam: 2.83 MeV/u were Coulomb excited using 60Ni, 114Cd, and 120Sn scattering targets. De-excitation γ-rays were detected employing the Miniball array and scattered particles were detected in a silicon detector. Exploiting the Coulomb-excitation code GOSIA for each nucleus several matrix elements could be obtained from the measured γ-ray yields. The extracted ‹3−||E3||0+› matrix element allows for the conclusion that, while 220Rn represents an octupole vibrational system, 224Ra has already substantial octupole correlations in its ground state. This finding has implications for the search of CP-violating Schiff moments in the atomic systems of the adjacent odd-mass nuclei.

  17. Investigation of $\\alpha$-decay rates of $^{221}$Fr, $^{224}$Ra and $^{226}$Ra in different environments

    2007-01-01

    It has recently been suggested, and indicated experimentally, that $\\alpha$- decay half-lives are modified by solid state effects in the surrounding environment. We propose here to measure with high accuracy the $\\alpha$-decay half-life of $^{221}$Fr, $^{224}$Ra and $^{226}$Ra in insulators and metals. Furthermore we plan to investigate the temperature dependency of the half-life in these materials (room temperature, 4 K and 10 mK).

  18. Solar Spectrum Synthesis. I. A Sample Atlas from 224 to 300 nm

    Kurucz, Robert L.; Avrett, Eugene H.

    1981-05-01

    We have developed sophisticated computer programs for determining solar and stellar atmospheric structure through the analysis of spectra. These programs allow us to treat the spectrum as a whole and to draw much stronger conclusions than would be apparent from individual spectral features. For a given LTE or non-LTE model atmosphere, the programs compute the emergent flux or the specific intensity at up to 20 angles. The spectrum can be broadened by macroturbulence and rotation; it can be modified by transmission through the Earth's atmosphere; it can be convolved with the instrumental profile; and it can finally be plotted together with the observed spectrum with each line labeled. In the opacity calculation, the lines are broadened by radiative, Stark, and van der Waals damping, and they can have isotopic and hyperfine splitting, autoionization, partial redistribution, or be merged into a continuum. The departure coefficients for ions treated in non-LTE in the model atmosphere calculation can be used in the spectrum synthesis programs for all lines of these ions, and highly ionized lines can be treated in the coronal approximation. The model atmosphere can have depth-dependent doppler shifts corresponding to large-scale motions. Using the Vernazza, Avrett, and Loeser models for the average quiet sun, we have computed theoretical solar spectra that include all available atomic and molecular line data. In this atlas we compare with the best available observed spectra in the 224- to 300-nm wavelength range, namely, the Kohl, Parkinson, and Kurucz (Harvard) center and limb rocket spectra in the range 224 to 300 nm; the Allen, McAllister, and Jefferies (Hawaii) disk center rocket spectrum for 268 to 293 nm; and the Brault and Testerman disk center spectrum taken at Kitt Peak for 294 to 300 nm. We also compare the observed spectra with each other. The existing spectra are noisy and do not have adequate resolution, so that it is difficult or impossible to identify weak

  19. Guidelines on chemotherapy in advanced stage gynecological malignancies: an evaluation of 224 professional societies and organizations.

    Nikolaos P Polyzos

    Full Text Available BACKGROUND: Clinical practice guidelines are important for guiding practice, but it is unclear if they are commensurate with the available evidence. METHODS: We examined guidelines produced by cancer and gynecological societies and organizations and evaluated their coverage of and stance towards chemotherapy for advanced stage disease among 4 gynecological malignancies (breast, ovarian, cervical, endometrial cancer where the evidence for the use of chemotherapy is very different (substantial and conclusive for breast and ovarian cancer, limited and suggesting no major benefit for cervical and endometrial cancer. Eligible societies and organizations were identified through systematic internet searches (last update June 2009. Pertinent websites were scrutinized for presence of clinical practice guidelines, and relative guidelines were analyzed. RESULTS: Among 224 identified eligible societies and organizations, 69 (31% provided any sort of guidelines, while recommendations for chemotherapy on advanced stage gynecological malignancies were available in 20 of them. Only 14 had developed their own guideline, and only 5 had developed guidelines for all 4 malignancies. Use of levels of evidence and grades of recommendations, and aspects of the production, implementation, and timeliness of the guidelines did not differ significantly across malignancies. Guidelines on breast and ovarian cancer utilized significantly more randomized trials and meta-analyses. Guidelines differed across malignancies on their coverage of disease-free survival (p = 0.033, response rates (p = 0.024, symptoms relief (p = 0.005, quality of life (p = 0.001 and toxicity (p = 0.039, with breast and ovarian cancer guidelines typically covering more frequently these outcomes. All guidelines explicitly or implicitly endorsed the use of chemotherapy. CONCLUSIONS: Clinical practice guidelines are provided by the minority of professional societies and organizations

  20. Long-term investigation of the risk of malignant diseases following intravenous radium-224 treatment for ankylosing spondylitis; Langzeituntersuchung zum Risiko maligner Erkrankungen nach intravenoeser Behandlung des Morbus Bechterew mit Radium-224

    Schulte, Tobias L. [Klinik und Poliklinik fuer Allgemeine Orthopaedie und Tumororthopaedie, Universitaetsklinikum Muenster (Germany); Nekolla, Elke A. [Bundesamt fuer Strahlenschutz (BfS), Neuherberg (Germany); Wick, Roland R. [Inst. fuer Strahlenbiologie, Helmholtz-Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt, Neuherberg (Germany)

    2009-09-15

    Background and purpose: in German-speaking countries, the intravenous treatment of ankylosing spondylitis (AS) with radium-224 ({sup 224}Ra) was common between the late 1940s and 2005. In this long-term investigation, the risk of malignant diseases following intravenous {sup 224}Ra treatment for AS was assessed. Patients and methods: in a prospective long-term study, 1,471 patients with AS who were treated with {sup 224}Ra between 1948 and 1975 have been followed together with a control group of 1,324 AS patients treated neither with radioactive drugs nor with X-rays. Standardized questionnaires to evaluate the patients' health status were used. Observed numbers of malignant diseases were compared with those of the control group as well as with expected numbers for a normal population. Results: After 26 years of follow-up, causes of death have been certified for 1,006 patients of the exposure group (control group: 1,072 patients). Significantly increased rates of myeloid leukemia (12 cases observed vs. 2.9 expected; p < 0.001), kidney cancer (18 vs. 9.1; p < 0.01), thyroid cancer (4 vs. 1.2; p = 0.03) and borderline significantly increased rates of cancer of female genital organs (10 vs. 5.6; p = 0.06) were found in the exposure group in contrast to no significant increases of these diseases in the control group. Rates of pulmonary and gastrointestinal malignancies were not increased. Lymphatic leukemia (exposure group: 8 vs. 2.7; p < 0.01; control group: 7 vs. 3; p = 0.03) was significantly elevated due to a high rate of chronic lymphatic leukemia in both, the exposure as well as the control group. Conclusion: treatment of AS with {sup 224}Ra led to increased incidences of myeloid leukemia and malignancies of kidneys, thyroid and female genital organs. Although this kind of therapy is now abandoned, there is a need for close follow-up of patients who received it. (orig.)

  1. Measurement of 223Ra and 224Ra via RaDeCC and its application at Liaohe River Estuary%辽河口水体中223Ra、224Ra的RaDeCC法测定及应用

    许博超; 姚庆祯; 江雪艳; 于志刚

    2012-01-01

    介绍了同步延时计数法,并应用其对辽河口水体中的223 Ra和224 Ra进行了测定,结合pH、DO、COD、叶绿素、营养盐等参数对223 Ra和224 Ra的放射性活度及其比值随盐度的变化和影响因素进行了讨论,继而以“镭同位素表观年龄模型”计算了辽河口水体的停留时间.结果表明:2010年4月,辽河口调查水域水体中的224 Ra、223 Ra随盐度变化趋势不保守,在盐度为10和26的海域出现了放射性活度高峰值,可能分别由悬浮颗粒物解吸和滨岸咸化的地下水排放等因素造成.水体停留时间随着离开河口距离的增大而增大,最大值出现在盐度为14的海域,达到8.34 d.%Radium delayed coincidence countering system has become the state-of-the-art technique for short-lived radium isotopes (223Ra, 224Ra) measurement. In this paper, we described this system, and used it to measure 223Ra, 224Ra activities at the Liaohe River Estuary. Other parameters, like pH, DO, COD, petroleum hydrocarbon, chlorophyll and nutrients, were used to demonstrate the distribution and impact factors of isotopes activity and ratio versus salinity. Furthermore, the "Apparent Radium Age" model was applied to assess the water residence time at this area. Ra and Ra were not conservative with salinity at the studying area in A-pril, 2010. Two peak activities at salinity 10 and 26 were caused by suspended particles desorption and submarine groundwater discharge , respectively. Water residence time increased with the distance. The oldest age was 8. 34 days at the area with salinity of 14.

  2. Solute transport into the Jiulong River estuary via pore water exchange and submarine groundwater discharge: New insights from 224Ra/228Th disequilibrium

    Hong, Qingquan; Cai, Pinghe; Shi, Xiangming; Li, Qing; Wang, Guizhi

    2017-02-01

    Pore water exchange (PEX) and submarine groundwater discharge (SGD) represent two mechanisms for solute transport from the seabed into the coastal ocean. However, their relative importance remains to be assessed. In this study, we pursued the recently developed 224Ra/228Th disequilibrium approach to quantify PEX fluxes of 224Ra into the Jiulong River estuary, China. By constructing a full mass balance of water column 224Ra, we were allowed to put various source terms, i.e., SGD, diffusive and advective pore water flow (PEX), and river input in a single context. This led to the first quantitative assessment of the relative importance of PEX vs. SGD in the delivery of solutes into an estuary. We carried out two surveys in the Jiulong River estuary: one in January 2014 (winter survey), the other in August 2014 (summer survey). By virtue of a 1-D mass balance model of 224Ra in the sediment column, we demonstrated that PEX fluxes of 224Ra were highly variable, both temporally and spatially, and can change by 1-2 orders of magnitude in our study area. Moreover, we identified a strong correlation between 224Ra-based irrigation rate and 234Th-based sediment mixing rate. Our results highlighted irrigation as the predominant PEX process for solute transfer across the sediment-water interface. Total PEX flux of 224Ra (in 1010 dpm d-1) into the Jiulong River estuary was estimated to be 22.3 ± 3.0 and 33.7 ± 5.5 during the winter and summer surveys, respectively. In comparison, total SGD flux of 224Ra (in 1010 dpm d-1) was 11.3 ± 8.6 and 49.5 ± 16.3 in the respective seasons. By multiplying the PEX fluxes of 224Ra by the ratio of the concentration gradients of component/224Ra at the sediment-water interface, we quantified the total PEX fluxes of dissolved inorganic carbon (DIC) and nutrients (NH4+, NO3-, and H4SiO4) into the Jiulong River estuary. In the meantime, net export of DIC and nutrients via SGD were estimated by multiplying the SGD fluxes of 224Ra by the DIC

  3. Study on the risk of late damage in humans after incorporation of the short-lived alpha emitter Ra-224; Studie zum Risiko von Spaetschaeden beim Menschen nach Inkorporation des kurzlebigen {alpha}-Strahlers Radium-224

    Wick, R.R.; Nekolla, E.A.; Kellerer, A.M. [Muenchen Univ. (Germany). Strahlenbiologisches Inst.; Goessner, W. [Gesellschaft fuer Strahlen- und Umweltforschung mbH Muenchen, Neuherberg (Germany). Inst. fuer Pathologie

    2003-07-01

    An epidemiological study has been carried out at the GSF - National Research Center for Environment and Health - between 1948 and 1975, on 1460 ankylosing spondylitis (AS) patients. The aim of the study was to ascertain the late health effects suffered by these patients who had received repeated intravenous injections of the short lived {alpha}-emitter {sup 224}Ra. These patients have been followed together with a control group of 1323 ankylosing spondylitis patients not treated with radioactive drugs and/or X-rays. Causes of death have been ascertained for 842 exposed patients and 861 controls by the end of 2002. In the exposed group there has been a total of 219 malignant diseases and 206 cases among the controls. In particular, we observed 15 cases of leukaemia in the exposure group and 8 cases of leukaemia in the control group. Further subclassification of the leukaemias demonstrated a high increase of myeloid leukaemia in the exposure group (9 cases obs. vs. 2.5 cases exp.), and out of these especially the acute myeloid leukaemias (6 cases observed vs. 1.6 expected), whereas in the control group the observed cases are within the expected range (3 myeloid leukaemias vs. 2.6 cases). Out of these 6 cases of myeloid leukaemia, 3 cases have been observed at doses comparable to those of the currently applied {sup 224}Ra treatment with the preparation SpondylAT {sup registered}, in one case the {sup 224}Ra-dose was the 0.6fold, in another case 1.6fold, whereas in one case the total dose could not be verified exactly. The enhanced leukaemia incidence in our exposed group is in line with results from animal experiments in mice having been injected with bone seeking {alpha}-emitters given at low dose rates. (orig.) [German] Im Rahmen einer epidemiologischen Studie werden im GSF-Forschungszentrum 1460 Bechterew-Patienten beobachtet, die in den Jahren 1948 bis 1975 zur Behandlung ihrer Krankheit wiederholte intravenoese Injektionen von {sup 224}Ra erhalten haben. Daneben

  4. 医院224株肠杆菌科细菌药物敏感性分析%Drug susceptibility analysis of 224 strains of Enterobacteriaceae in the hospital

    王薇薇; 丁建平; 钱晨焰; 陈亮

    2016-01-01

    OBJECTIVE To analyze the drug susceptibility of 224 strains of Enterobacteriaceae to 21 kinds of antibi-otics in the hospital ,so as to guide rational use of antibiotics .METHODS A total of 224 strains of Enterobacteri-aceae infection specimens from Aug .2014 to Apr .2016 in the hospital were retrospectively analyzed .The distribu-tion of Enterobacteriaceae in different specimens and departments were analyzed ,the bacteria were identified and their drug susceptibility were analyzed by the susceptibility analyzer and the susceptibility of Enterobacteriaceae to 21 kinds of antibiotics were detected .RESULTS Among 224 strains of Enterobacteriaceae isolates ,42 .86% (96 strains) were isolated from the sputum ,27 .68% (62 strains) from the urine ,and 12 .05% (27 strains) from the blood;The top three departments were internal medicine(68 .30% ,153 strains) ,surgery(12 .50% ,28 strains) and outpatients(11 .16% ,25 strains) ,respectively .The drug resistant rates of 224 strains of Enterobacteriaceae to piperacillin/tazobactam ,cefoperazone/sulbactam ,and imipenem were 1 .3% ,1 .8% ,and 4% .respectively , The drug resistant rate to ampicillin was the highest ,which was 84 .4% .The drug resistant rates to lomefloxacin , levofloxacin ,and ciprofloxacin were 47 .8% ,44 .2% ,and 46% ,respectively .CONCLUSION Enterobacteriaceae are mainly isolated from respiratory system and urinary system ,the drug resistant rates were low to carbapenems ,β-lactamase/β-lactamase inhibitor ,while the drug resistant rates of Enterobacteriaceae isolated from urine to quin-olone were higher than from other specimens .The issue should be paid more attention and we should strengthen the rational use of antibiotics .%目的:分析医院224株肠杆菌科细菌对21种抗菌药物的药物敏感情况,指导临床合理用药。方法回顾性分析医院2014年8月—2016年4月临床送检224株肠杆菌科细菌感染的标本,分析肠杆菌科细菌在不同标本以及不同临床科室

  5. Measurements of octupole collectivity in $^{220,222}$Rn and $^{222,224}$Ra using Coulomb excitation

    Kruecken, R; Larsen, A; Hurst, A M; Voulot, D; Grahn, T; Clement, E; Wadsworth, R; Gernhaeuser, R A; Siem, S; Huyse, M L; Iwanicki, J S

    2008-01-01

    We propose to exploit the unique capability of ISOLDE to provide post-accelerated $^{220,222}$Rn and $^{222,224}$Ra ion beams from the REX facility to enable the Coulomb excitation of the first 3$^{-}$ states in these nuclei. By measuring the $\\gamma$-ray yields of the E1 decays from the 3$^{-}$ state using the MINIBALL array we can obtain the transition matrix elements. This will give quantitative information about octupole correlations in these nuclei. We require 22 shifts to fulfil the aims of the experiment.

  6. Influence of Neutron Shell Closure (Nc=126) on Prescission Particle Emission of Fissioning Systems 216,224Th

    叶巍

    2003-01-01

    The effect of neutron shell closure Nc = 126 on the prescission-particle emission of 216Th and 224Th nuclei is investigated within the framework of an extensive Smoluchowski equation. It is found that there is a large difference in the prescission neutron multiplicity for the two Th nuclei, indicating a strong shell effect in neutron emission. Moreover, shell effects on particle emission are also investigated as functions of excitation energy,angular momentum and nuclear viscosity. The results show that with increasing excitation energy shell effects in prefission neutron evolve from continual strength to gradual weakness. Both high angular momenta and low viscosity weaken the shell effects on the particle emission.

  7. Occurrence of radium-224, radium-226, and radium-228 in water of the unconfined Kirkwood-Cohansey aquifer system, southern New Jersey

    Szabo, Zoltan; dePaul, Vincent T.; Kraemer, Thomas F.; Parsa, Bahman

    2005-01-01

    Water in the unconfined Kirkwood-Cohansey aquifer system in the New Jersey Coastal Plain contains elevated concentrations (above 3 pCi/L (picocuries per liter)) of the alpha-particle-emitting radionuclide radium-224. Previously, water from the aquifer system had been found to contain radium-226 and radium-228. This observation is of concern because the previously undetected presence of radium-224 may pose an additional, quantifiable health risk that currently is not accounted for by the Maximum Contaminant Level (MCL) of 5 pCi/L for combined radium (the sum of radium-226 plus radium-228 is termed 'combined radium') in drinking water. Water samples were collected from a regional network of 88 wells for determination of concentrations of radium-224, radium-226, and radium-228; gross alpha-particle activity; and concentrations of major ions and selected trace elements. Both gamma and alpha spectroscopic techniques were used to determine concentrations of radium-224, which ranged from activity of about 15 pCi/L (the MCL) 36 to 48 hours, respectively, after sample collection when ingrowth of radium-224 progeny radionuclides is considered, even with the unlikely assumption that no other alpha-particle-emitting radionuclide is present in the water. Concentrations of 3.4 to 3.7 pCi/L radium-224 result in a gross alpha-particle activity of 10 pCi/L 36 to 48 hours, respectively, after sample collection when ingrowth of Ra-224 progeny radionuclides is considered. In this latter case, it is possible that the summed alpha-particle activity from radium-226 present at a concentration less than or equal to 5 pCi/L (the MCL for combined radium) and from radium-224 present at a concentration about 3.4 pCi/L or greater may exceed the 15-pCi/L MCL for gross alpha-particle activity. In this study, gross alpha-particle activities were measured within 48 hours after sample collection and were found to exceed the MCL of 15 pCi/L in nearly half (43) of the 88 samples collected. The

  8. MicroRNA-224 is Readily Detectable in Urine of Individuals with Diabetes Mellitus and is a Potential Indicator of Beta-Cell Demise

    Siobhán Bacon

    2015-06-01

    Full Text Available MicroRNA (miRNA are a class of non-coding, 19–25 nucleotide RNA critical for network-level regulation of gene expression. miRNA serve as paracrine signaling molecules. Using an unbiased array approach, we previously identified elevated levels of miR-224 and miR-103 to be associated with a monogenic form of diabetes; HNF1A-MODY. miR-224 is a novel miRNA in the field of diabetes. We sought to explore the role of miR-224 as a potential biomarker in diabetes, and whether such diabetes-associated-miRNA can also be detected in the urine of patients. Absolute levels of miR-224 and miR-103 were determined in the urine of n = 144 individuals including carriers of a HNF1A mutation, participants with type 1 diabetes mellitus (T1DM, type 2 diabetes mellitus (T2DM and normal controls. Expression levels were correlated with clinical and biochemical parameters. miR-224 was significantly elevated in the urine of carriers of a HNF1A mutation and participants with T1DM. miR-103 was highly expressed in urine across all diabetes cohorts when compared to controls. For both miR-224 and-103, we found a significant correlation between serum and urine levels (p < 0.01. We demonstrate that miRNA can be readily detected in the urine independent of clinical indices of renal dysfunction. We surmise that the differential expression levels of miR-224 in both HNF1A-MODY mutation carriers and T1DM may be an attempt to compensate for beta-cell demise.

  9. Diapycnal nutrient fluxes across the benthic boundary layers at the continental slopes off Peru and Mauritania based on 224Ra/223Ra-ratios

    Reichert, P.; Scholten, J. C.; Eisenhauer, A.; Miquel, J. C.; Gasser, B.; Liebetrau, V.; Sommer, S.; Dengler, M.; Bryant, L. D.

    2014-12-01

    Marine sediments may act as sources and/or sinks of nutrients in oxygen minimum zones (OMZs) where solute fluxes between sediments and the above water column are believed to be an important component for the bioproductivity in the mixed layer. However, solute fluxes between sediments and the water column above are difficult to obtain. We determined the diapycnal nutrient fluxes across the benthic boundary layer at the OMZs off Peru and Mauritania using nutrient concentration profiles and vertical diffusion coefficients derived from 224Ra/223Ra isotope ratios. The radium isotopes 223Ra (half-life: 11.4 days) and 224Ra (half-life: 3.66 days) are produced in sediments by radioactive decay of 227Th and 228Th ,respectively: Diffusion of radium out of the sediments results in gradients of 224Ra/223Ra above the sediments; and these gradients may be used to estimate vertical diffusion coefficients. We determined 224Ra/223Ra along two transects at the continental slopes off Peru (12° S) and off Mauritania (18° N) in water depths between 65m - 1000mand 53m - 1100m, respectively. For the 223Ra/224Ra sampling we used acrylic fibers/cartridges coated with MnO2. The Mn-fibers were attached to benthic landers (moored for ~ 24 hours at the sea floor) and the Mn-cartridges were placed in series on several in-situ filtration pumps (Challenger Oceanic and McLane pumps). 223Ra and 224Ra were measured on-board using a delayed coincidence counting system (RaDeCC). In our presentation we will present the 224Ra/223Ra distribution along these transects investigated and we will compare the diapycnal radium-derived nutrient fluxes with those determined using benthic chambers and microstructure measurements.

  10. Oral health education to 224 cases of pregnancy women's oral health impact study%口腔健康教育对224例妊娠期妇女口腔健康影响研究

    胡芳; 李健; 万燕燕

    2013-01-01

    Objective:To explore oral health education effect on pregnancy women's oral health.methods:224 patients were randomly divided into the treatment group 224 examples (for oral health education in patients with pregnancy) and the control group, 114 cases of oral health education (no). Observe two groups of pregnancy women's oral health.results:110 cases of late pregnancy women after oral health education during pregnancy gingivitis incidence of 3.63%, 1.81%incidence of tooth decay, periodontal disease incidence of 1.81%, wisdom tooth pericoronitis incidence of 2.72%. The total incidence of 10%.conclusion:Oral health education for women during pregnancy gingivitis and dental caries, periodontal disease, wisdom tooth pericoronitis incidence decreased significantly. Oral health education should pay more at ention to pregnant women.%目的:探讨口腔健康教育对妊娠期妇女口腔健康影响。方法:224例患者随机分为治疗组110例(对妊娠期患者进行口腔健康教育)与对照组114例(没有进行口腔健康教育)。观察两组妊娠期妇女口腔健康状况。结果:110例妊娠期妇女经过口腔健康教育后妊娠后期龈炎发病率3.63%,龋病发病率1.81%,牙周病发病率1.81%,智齿冠周炎发病率2.72%。总发病率10%。结论:口腔健康教育对妊娠期妇女牙龈炎、龋齿、牙周病、智齿冠周炎的发病率显著降低。孕妇口腔健康教育应当更加重视。

  11. Analysis of Antibiotic Use in 224 Surgical Cases in Beijing Fangshan District First Hospital%北京市房山区第一医院224份手术病历抗菌药物应用分析

    王秀云; 刘洋; 周秋峰

    2015-01-01

    目的:了解北京市房山区第一医院(以下简称“我院”)手术患者中抗菌药物的使用情况、使用特点及存在的问题,为临床合理应用抗菌药物提供参考。方法:随机抽取2013年我院224份手术病历,对患者情况、抗菌药物使用情况、手术情况、切口类别等进行统计分析。结果:224份病历中,Ⅰ类切口手术68例,占30.4%,抗菌药物使用率为29.4%,主要使用的抗菌药物为注射用头孢呋辛;Ⅱ类切口手术137例,占61.2%,主要使用的抗菌药物为注射用头孢呋辛、注射用头孢拉定、注射用头孢西丁、注射用奥硝唑、头孢呋辛酯片等。结论:我院手术患者抗菌药物的使用情况基本合理,但在抗菌药物使用剂量、频次、使用时间及联合用药等方面仍存在问题,需要继续加强抗菌药物合理使用的培训与宣传工作,促进临床合理用药。%OBJECTIVE:To investigate the status quo , characteristics and problems in the antibiotic use in surgical cases in Beijing Fangshan District First Hospital ( hereinafter referred to as “our hospital”) for reference of clinical rational use of antibiotics .METHODS:A total of 224 records of surgical cases in our hospital were randomly selected in 2013 for statistical analysis regarding patients'status, antibiotic use, surgery, incision type etc.RESULTS:Of the 224 cases, 68(30.4%) underwent type Ⅰincision surgery with 29.4%treated with antibiotics, predominantly cefuroxime for injection; 137 ( 61.2%) underwent type Ⅱ incision surgery , for whom the antibiotics including cefuroxime sodium for injection , cefradine for Injection , ornidazole for Injection and cefuroxime axetil tablets were used predominantly .CONCLUSIONS:The antibiotic use in surgical cases in our hospital was basically rational; however , there are still problems in dose , frequency and time of administration and combination therapy .It is important to

  12. Energy dependence of pi-zero production in Cu+Cu collisions at sqrt(s_NN) = 22.4, 62.4, and 200 GeV

    Adare, A; Aidala, C; Ajitanand, N N; Akiba, Y; Al-Bataineh, H; Alexander, J; Aoki, K; Aphecetche, L; Armendariz, R; Aronson, S H; Asai, J; Atomssa, E T; Averbeck, R; Awes, T C; Azmoun, B; Babintsev, V; Bai, M; Baksay, G; Baksay, L; Baldisseri, Alberto; Barish, K N; Barnes, P D; Bassalleck, B; Basye, A T; Bathe, S; Batsouli, S; Baublis, V; Baumann, C; Bazilevsky, A; Belikov, S; Bennett, R; Berdnikov, A; Berdnikov, Y; Bickley, A A; Boissevain, J G; Borel, H; Boyle, K; Brooks, M L; Büsching, H; Bumazhnov, V; Bunce, G; Butsyk, S; Camacho, C M; Campbell, S; Chang, B S; Chang, W C; Charvet, J L; Chernichenko, S; Chiba, J; Chi, C Y; Chiu, M; Choi, I J; Choudhury, R K; Chujo, T; Chung, P; Churyn, A; Cianciolo, V; Citron, Z; Cleven, C R; Cole, B A; Comets, M P; Constantin, P; Csanad, M; Csrgo, T; Dahms, T; Dairaku, S; Das, K; Dávid, G; Deaton, M B; Dehmelt, K; Delagrange, H; Denisov, A; d'Enterria, D; Deshpande, A; Desmond, E J; Dietzsch, O; Dion, A; Donadelli, M; Drapier, O; Drees, A; Drees, K A; Dubey, A K; Durum, A; Dutta, D; Dzhordzhadze, V; Efremenko, Yu V; Egdemir, J; Ellinghaus, F; Emam, W S; Engelmore, T; Enokizono, A; Enyo, H; Esumi, S; Eyser, K O; Fadem, B; Fields, D E; Finger, M; Finger, M; Fleuret, F; Fokin, S L; Fraenkel, Zeev; Frantz, J E; Franz, A; Frawley, A D; Fujiwara, K; Fukao, Y; Fusayasu, T; Gadrat, S; Garishvili, I; Glenn, A; Gong, H; Gonin, M; Gosset, J; Goto, Y; Granier de Cassagnac, R; Grau, N; Greene, S V; Grosse-Perdekamp, M; Gunji, T; Gustafsson, H; Hachiya, T; Hadj Henni, A; Haegemann, C; Haggerty, J S; Hamagaki, H; Han, AR; Harada, H; Hartouni, E P; Haruna, K; Haslum, E; Hayano, R; Heffner, M; Hemmick, T K; Hester, T; He, X; Hiejima, H; Hill, J C; Hobbs, R; Hohlmann, M; Holzmann, W; Homma, K; Hong, B; Horaguchi, T; Hornback, D; Huang, S; Ichihara, T; Ichimiya, R; Ikeda, Y; Imai, K; Imrek, J; Inaba, M; Inoue, Y; Isenhower, D; Isenhower, L; Ishihara, M; Isobe, T; Issah, M; Isupov, A; Ivanischev, D; Jacak, B V; Jia, J; Jin, J; Jinnouchi, O; Johnson, B M; Joo, K S; Jouan, D; Kajihara, F; Kametani, S; Kamihara, N; Kamin, J; Kaneta, M; Kang, J H; Kanou, H; Kapustinsky, J; Kawall, D; Kazantsev, A V; Khanzadeev, A; Kijima, K M; Kikuchi, J; Kim, B I; Kim, D H; Kim, D J; Kim, E; Kim, S H; Kinney, E; Kiriluk, K; Kiss, A; Kistenev, E; Kiyomichi, A; Klay, J; Klein-Bösing, C; Kochenda, L; Kochetkov, V; Komkov, B; Konno, M; Koster, J; Kotchetkov, D; Kozlov, A; Krl, A; Kravitz, A; Kubart, J; Kunde, G J; Kurihara, N; Kurita, K; Kurosawa, M; Kweon, M J; Kwon, Y; Kyle, G S; Lacey, R; Lai, Y S; Lai, Y S; Lajoie, J G; Layton, D; Lebedev, A; Lee, D M; Lee, K B; Lee, M K; Lee, T; Leitch, M J; Leite, M A L; Lenzi, B; Liebing, P; Lika, T; Litvinenko, A; Liu, H; Liu, M X; Li, X; Love, B; Lynch, D; Maguire, C F; Makdisi, Y I; Malakhov, A; Malik, M D; Man'ko, V I; Mannel, E; Mao, Y; Maek, L; Masui, H; Matathias, F; McCumber, M; McGaughey, P L; Means, N; Meredith, B; Miake, Y; Mike, P; Miki, K; Miller, T E; Milov, A; Mioduszewski, S; Mishra, M; Mitchell, J T; Mitrovski, M; Mohanty, A K; Morino, Y; Morreale, A; Morrison, D P; Moukhanova, T V; Mukhopadhyay, D; Murata, J; Nagamiya, S; Nagata, Y; Nagle, J L; Naglis, M; Nagy, M I; Nakagawa, I; Nakamiya, Y; Nakamura, T; Nakano, K; Newby, J; Nguyen, M; Niita, T; Norman, B E; Nouicer, R; Nyanin, A S; O'Brien, E; Oda, S X; Ogilvie, C A; Ohnishi, H; Okada, H; Okada, K; Oka, M; Omiwade, O O; Onuki, Y; Oskarsson, A; Ouchida, M; Ozawa, K; Pak, R; Pal, D; Palounek, A P T; Pantuev, V; Papavassiliou, V; Park, J; Park, W J; Pate, S F; Pei, H; Peng, J C; Pereira, H; Peresedov, V; Peressounko, D Yu; Pinkenburg, C; Purschke, M L; Purwar, A K; Qu, H; Rak, J; Rakotozafindrabe, A; Ravinovich, I; Read, K F; Rembeczki, S; Reuter, M; Reygers, K; Riabov, V; Riabov, Y; Roach, D; Roche, G; Rolnick, S D; Romana, A; Rosati, M; Rosendahl, S S E; Rosnet, P; Rukoyatkin, P; Ruika, P; Rykov, V L; Sahlmueller, B; Saitô, N; Sakaguchi, T; Sakai, S; Sakashita, K; Sakata, H; Samsonov, V; Sato, S; Sato, T; Sawada, S; Sedgwick, K; Seele, J; Seidl, R; Semenov, A Yu; Semenov, V; Seto, R; Sharma, D; Shein, I; Shevel, A; Shibata, T A; Shigaki, K; Shimomura, M; Shoji, K; Shukla, P; Sickles, A; Silva, C L; Silvermyr, D; Silvestre, C; Sim, K S; Singh, B K; Singh, C P; Singh, V; Skutnik, S; Sluneka, M; Soldatov, A; Soltz, R A; Sondheim, W E; Sørensen, S P; Sourikova, I V; Staley, F; Stankus, P W; Stenlund, E; Stepanov, M; Ster, A; Stoll, S P; Sugitate, T; Suire, C; Sukhanov, A; Sziklai, J; Tabaru, T; Takagi, S; Takagui, E M; Taketani, A; Tanabe, R; Tanaka, Y; Tanida, K; Tannenbaum, M J; Taranenko, A; Tarjn, P; Themann, H; Thomas, T L; Togawa, M; Toia, A; Tojo, J; Tomaek, L; Tomita, Y; Torii, H; Towell, R S; Tram, V-N; Tserruya, Itzhak; Tsuchimoto, Y; Vale, C; Valle, H; van Hecke, H W; Veicht, A; Velkovska, J; Vertesi, R; Vinogradov, A A; Virius, M; Vrba, V; Vznuzdaev, E; Wagner, M; Walker, D; Wang, X R; Watanabe, Y

    2008-01-01

    Neutral pion transverse momentum (pT) spectra at mid-rapidity (|y| < 0.35) were measured in Cu+Cu collisions at \\sqrt s_NN = 22.4, 62.4, and 200 GeV. Relative to pi -zero yields in p+p collisions scaled by the number of inelastic nucleon-nucleon collisions (Ncoll) at the respective energies, the pi-zero yields for pT \\ge 2 GeV/c in central Cu+Cu collisions at 62.4 and 200 GeV are suppressed, whereas an enhancement is observed at 22.4 GeV. A comparison with a jet quenching model suggests that final state parton energy loss dominates in central Cu+Cu collisions at 62.4 GeV and 200 GeV, while the enhancement at 22.4 GeV is consistent with nuclear modifications in the initial state alone.

  13. Onset of pi(0) suppression studied in Cu+Cu collisions at sqrt S NN=22.4, 62.4, and 200 GeV.

    Adare, A; Afanasiev, S; Aidala, C; Ajitanand, N N; Akiba, Y; Al-Bataineh, H; Alexander, J; Aoki, K; Aphecetche, L; Armendariz, R; Aronson, S H; Asai, J; Atomssa, E T; Averbeck, R; Awes, T C; Azmoun, B; Babintsev, V; Bai, M; Baksay, G; Baksay, L; Baldisseri, A; Barish, K N; Barnes, P D; Bassalleck, B; Basye, A T; Bathe, S; Batsouli, S; Baublis, V; Baumann, C; Bazilevsky, A; Belikov, S; Bennett, R; Berdnikov, A; Berdnikov, Y; Bickley, A A; Boissevain, J G; Borel, H; Boyle, K; Brooks, M L; Buesching, H; Bumazhnov, V; Bunce, G; Butsyk, S; Camacho, C M; Campbell, S; Chang, B S; Chang, W C; Charvet, J-L; Chernichenko, S; Chiba, J; Chi, C Y; Chiu, M; Choi, I J; Choudhury, R K; Chujo, T; Chung, P; Churyn, A; Cianciolo, V; Citron, Z; Cleven, C R; Cole, B A; Comets, M P; Constantin, P; Csanád, M; Csörgo, T; Dahms, T; Dairaku, S; Das, K; David, G; Deaton, M B; Dehmelt, K; Delagrange, H; Denisov, A; d'Enterria, D; Deshpande, A; Desmond, E J; Dietzsch, O; Dion, A; Donadelli, M; Drapier, O; Drees, A; Drees, K A; Dubey, A K; Durum, A; Dutta, D; Dzhordzhadze, V; Efremenko, Y V; Egdemir, J; Ellinghaus, F; Emam, W S; Engelmore, T; Enokizono, A; En'yo, H; Esumi, S; Eyser, K O; Fadem, B; Fields, D E; Finger, M; Finger, M; Fleuret, F; Fokin, S L; Fraenkel, Z; Frantz, J E; Franz, A; Frawley, A D; Fujiwara, K; Fukao, Y; Fusayasu, T; Gadrat, S; Garishvili, I; Glenn, A; Gong, H; Gonin, M; Gosset, J; Goto, Y; Granier de Cassagnac, R; Grau, N; Greene, S V; Grosse Perdekamp, M; Gunji, T; Gustafsson, H-A; Hachiya, T; Hadj Henni, A; Haegemann, C; Haggerty, J S; Hamagaki, H; Han, R; Harada, H; Hartouni, E P; Haruna, K; Haslum, E; Hayano, R; Heffner, M; Hemmick, T K; Hester, T; He, X; Hiejima, H; Hill, J C; Hobbs, R; Hohlmann, M; Holzmann, W; Homma, K; Hong, B; Horaguchi, T; Hornback, D; Huang, S; Ichihara, T; Ichimiya, R; Ikeda, Y; Imai, K; Imrek, J; Inaba, M; Inoue, Y; Isenhower, D; Isenhower, L; Ishihara, M; Isobe, T; Issah, M; Isupov, A; Ivanischev, D; Jacak, B V; Jia, J; Jin, J; Jinnouchi, O; Johnson, B M; Joo, K S; Jouan, D; Kajihara, F; Kametani, S; Kamihara, N; Kamin, J; Kaneta, M; Kang, J H; Kanou, H; Kapustinsky, J; Kawall, D; Kazantsev, A V; Kempel, T; Khanzadeev, A; Kijima, K M; Kikuchi, J; Kim, B I; Kim, D H; Kim, D J; Kim, E; Kim, S H; Kinney, E; Kiriluk, K; Kiss, A; Kistenev, E; Kiyomichi, A; Klay, J; Klein-Boesing, C; Kochenda, L; Kochetkov, V; Komkov, B; Konno, M; Koster, J; Kotchetkov, D; Kozlov, A; Král, A; Kravitz, A; Kubart, J; Kunde, G J; Kurihara, N; Kurita, K; Kurosawa, M; Kweon, M J; Kwon, Y; Kyle, G S; Lacey, R; Lai, Y-S; Lai, Y S; Lajoie, J G; Layton, D; Lebedev, A; Lee, D M; Lee, K B; Lee, M K; Lee, T; Leitch, M J; Leite, M A L; Lenzi, B; Liebing, P; Liska, T; Litvinenko, A; Liu, H; Liu, M X; Li, X; Love, B; Lynch, D; Maguire, C F; Makdisi, Y I; Malakhov, A; Malik, M D; Manko, V I; Mannel, E; Mao, Y; Masek, L; Masui, H; Matathias, F; McCumber, M; McGaughey, P L; Means, N; Meredith, B; Miake, Y; Mikes, P; Miki, K; Miller, T E; Milov, A; Mioduszewski, S; Mishra, M; Mitchell, J T; Mitrovski, M; Mohanty, A K; Morino, Y; Morreale, A; Morrison, D P; Moukhanova, T V; Mukhopadhyay, D; Murata, J; Nagamiya, S; Nagata, Y; Nagle, J L; Naglis, M; Nagy, M I; Nakagawa, I; Nakamiya, Y; Nakamura, T; Nakano, K; Newby, J; Nguyen, M; Niita, T; Norman, B E; Nouicer, R; Nyanin, A S; O'Brien, E; Oda, S X; Ogilvie, C A; Ohnishi, H; Okada, H; Okada, K; Oka, M; Omiwade, O O; Onuki, Y; Oskarsson, A; Ouchida, M; Ozawa, K; Pak, R; Pal, D; Palounek, A P T; Pantuev, V; Papavassiliou, V; Park, J; Park, W J; Pate, S F; Pei, H; Peng, J-C; Pereira, H; Peresedov, V; Peressounko, D Yu; Pinkenburg, C; Purschke, M L; Purwar, A K; Qu, H; Rak, J; Rakotozafindrabe, A; Ravinovich, I; Read, K F; Rembeczki, S; Reuter, M; Reygers, K; Riabov, V; Riabov, Y; Roach, D; Roche, G; Rolnick, S D; Romana, A; Rosati, M; Rosendahl, S S E; Rosnet, P; Rukoyatkin, P; Ruzicka, P; Rykov, V L; Sahlmueller, B; Saito, N; Sakaguchi, T; Sakai, S; Sakashita, K; Sakata, H; Samsonov, V; Sato, S; Sato, T; Sawada, S; Sedgwick, K; Seele, J; Seidl, R; Semenov, A Yu; Semenov, V; Seto, R; Sharma, D; Shein, I; Shevel, A; Shibata, T-A; Shigaki, K; Shimomura, M; Shoji, K; Shukla, P; Sickles, A; Silva, C L; Silvermyr, D; Silvestre, C; Sim, K S; Singh, B K; Singh, C P; Singh, V; Skutnik, S; Slunecka, M; Soldatov, A; Soltz, R A; Sondheim, W E; Sorensen, S P; Sourikova, I V; Staley, F; Stankus, P W; Stenlund, E; Stepanov, M; Ster, A; Stoll, S P; Sugitate, T; Suire, C; Sukhanov, A; Sziklai, J; Tabaru, T; Takagi, S; Takagui, E M; Taketani, A; Tanabe, R; Tanaka, Y; Tanida, K; Tannenbaum, M J; Taranenko, A; Tarján, P; Themann, H; Thomas, T L; Togawa, M; Toia, A; Tojo, J; Tomásek, L; Tomita, Y; Torii, H; Towell, R S; Tram, V-N; Tserruya, I; Tsuchimoto, Y; Vale, C; Valle, H; vanHecke, H W; Veicht, A; Velkovska, J; Vertesi, R; Vinogradov, A A; Virius, M; Vrba, V; Vznuzdaev, E; Wagner, M; Walker, D

    2008-10-17

    Neutral pion transverse momentum (p(T)) spectra at midrapidity (|y| less than or approximately 0.35) were measured in Cu+Cu collisions at sqrt[s(NN)]=22.4, 62.4, and 200 GeV. Relative to pi_(0) yields in p+p collisions scaled by the number of inelastic nucleon-nucleon collisions (N(coll) the pi_(0) yields for p(T) more than or approximately 2 GeV/c in central Cu+Cu collisions are suppressed at 62.4 and 200 GeV whereas an enhancement is observed at 22.4 GeV. A comparison with a jet-quenching model suggests that final state parton energy loss dominates in central Cu+Cu collisions at 62.4 and 200 GeV, while the enhancement at 22.4 GeV is consistent with nuclear modifications in the initial state alone.

  14. Analysis of clinical characteristics and drug resistance of 224 strains of Acinetobacter baumannii infection%224例鲍曼不动杆菌感染的临床特征及耐药性分析

    徐薛芬; 徐爱晖

    2013-01-01

    目的 了解我院224例鲍曼不动杆菌感染的临床特征及耐药性.方法 采用常规方法进行细菌培养、菌株鉴定及药敏检测.结果 201名患者共分离出224株鲍曼不动杆菌,患者主要集中在ICU(33.8%)、外科(25.9%)、呼吸内科(14.4%)、骨科(6.1%),基础疾病以呼吸系统疾病(64.2%)、心血管系统疾病(30.8%)、神经系统疾病(29.8%)及糖尿病(22.9%)多见,与手术治疗及有创检查治疗(56.7%)、联合使用≥2种抗生素(80.6%)及使用时间≥15天(38.8%)可能存在相关性.224株鲍曼不动杆菌对米诺环素敏感性最高(66.1%),对美罗培南、氨苄西林/舒巴坦、头孢哌酮/舒巴坦敏感性超过55%.结论 鲍曼不动杆菌感染与患者有基础疾病、有创性检查治疗及使用广谱抗生素及时间过长有关,其耐药情况严重,多重耐药及泛耐药菌株日益增多,目前对米诺环素、舒巴坦、碳青酶烯类抗生素仍保持相对敏感性,临床应根据药敏结果合理选择使用抗生素.%Objective To investigate the clinical charateristics of infection of 224 Acinetobacter baumannii strains, and to analyze drug resistance of Acinetobacter baumannii strains. Methods The isolation of the bacterium was conducted according to the microorganical method of CLSI ( Clinical and Laboratory Standards Institute ). American DATE Company MicroScan Walkway-40 automatic analyzer was applied to identification and drug susceptibility test. Drug resistance was calculated with WH0NET5. 4 soitware. Results A total of 224 strains of Acinetobacter baumannii were isolated from 201 patients. The patients were mainly from ICU( intensive care uint) ( 33. 8% ), department of surgery ( 25. 9% ), department of respiratory medicine ( 14. 4% ), department of orthopedics ( 6. 1% ). Common underlying diseases were pulmonary diseases ( 64. 2% ), cardiovascular diseases ( 30. 8% ), diseases of nervous system ( 29. 8% ) and diabetes ( 22. 9% ). 56. 7% of the patients had

  15. Electroacupuncture Combined with Flash Cupping for Treatment of Peripheral Facial Paralysis ——A Report of 224 Cases

    Tian Jianqi; Duan Shumin

    2007-01-01

    Objective: To observe the therapeutic effects of electroacupuncture plus flash cupping for peripheral facial paralysis. Method: The main points used were Jingming (BL 1), Yangbai (GB 14) and Sibai (ST 2) with the adjunct points selected according to the syndrome differentiation. The routine acupuncture,electroacupuncture and flash cupping were used to treat 224 cases of peripheral facial paralysis. Result:The total effective rate was 96%. Conclusion: Acupuncture can regulate the flow of blood and qi and dredge the channels and collaterals; the pulse electrotherapy can enhance excitation of the muscular tissues;and the flash cupping can make the local tissues to be in a state of high oxygen supply, benefiting blood circulation. The synergistic action of electroacupuncture and flash cupping can raise the therapeutic effect.

  16. Synthesis, photo-physical and DFT studies of ESIPT inspired novel 2-(2',4'-dihydroxyphenyl) benzimidazole, benzoxazole and benzothiazole.

    Patil, Vikas S; Padalkar, Vikas S; Tathe, Abhinav B; Gupta, Vinod D; Sekar, N

    2013-09-01

    Novel ESIPT inspired benzimidazole, benzoxazole and benzothiazole were synthesized from 2,4-dihydroxy benzoic acid and 1,2-phenelenediamine, 2-aminophenol, and 2-aminothiophenol respectively. The synthesized 2-(2',4'-dihydroxyphenyl) benzimidazole, benzoxazole and benzothiazole are fluorescent and the emission characteristic are very sensitive to the micro-environment. They show a single absorption and dual emission with large Stokes shift originating from excited state intramolecular proton transfer. The absorption-emission characteristics of all these compounds are studied as a function of pH. The change in the electronic transition, energy levels, and orbital diagrams of synthesized compounds were investigated by the molecular orbital calculation and were correlated with the experimental spectral emission. Experimental absorption and emission wavelengths are in good agreement with those predicted using the Density Functional Theory (DFT) and Time-Dependent Density Functional Theory (TD-DFT) [B3LYP/6-31G(d)].

  17. Hydrogen generation from 2,2,4-trimethyl pentane reforming over molybdenum carbide at low steam-to-carbon ratios

    Cheekatamarla, Praveen K.; Thomson, William J.

    Because of the need for an efficient and inexpensive reforming catalyst, the objective of this work is to determine the feasibility of employing Mo 2C catalyst for the steam reforming and oxy-steam reforming of the higher hydrocarbons typical of transportation fuels such as gasoline. It is shown that bulk Mo 2C catalysts can successfully reform 2,2,4-trimethyl pentane (isooctane) to generate H 2, CO and CO 2 at very low steam/carbon ratios, without coke formation, eliminating the need for pre-reforming. Maximum hydrogen generation was observed at a S/C ratio of 1.3 and 1000 °C during SR reactions and S/C of 0.71, O 2/C of 0.12 at 900 °C during oxidative steam reforming reactions.

  18. Activation of endogenous C-type retroviral genomes by internal alpha-irradiation of mice with /sup 224/Radium

    Schmidt, J.; Erfle, V.; Mueller, W.A.

    1985-01-01

    Sensitive co-cultivation techniques were applied to study the radiation-induced activation of endogenous retroviral genomes in different mouse strains by the alpha-emitting radionuclide /sup 224/Radium. Activated infectious C-type retroviruses were detected in spleen, bone marrow and bone tissues of C57BL/6-, BALB/c- and NMRI mice. The titres of high-dose-irradiated animals were higher than those found in low-dose-irradiated animals. Infectious retrovirus could be detected with a dose of 13.2 rad (maximum dose rate 0.9 rad/day) in the skeleton, and a dose of 4.2 rad (maximum dose rate 0.3 rad/day) in the spleen. The virus activation pattern was different in the three mouse strains. These data indicate that activation of endogenous retroviral genomes by alpha-irradiation shows a dose-effect relationship and a dependence on the genetic background of the mouse.

  19. 25 CFR 224.83 - What must a tribe do after executing a lease or business agreement, or granting a right-of-way?

    2010-04-01

    ... Agreements, and Rights-Of-Way Under A Tera § 224.83 What must a tribe do after executing a lease or business agreement, or granting a right-of-way? Following the execution of a lease, business agreement, or grant of right-of-way under a TERA, a tribe must: (a) Inform the public of approval of the lease,...

  20. DEVELOPMENT OF A PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODEL FOR THE INHALATION OF 2,2,4-TRIMETHYLPENTANE (TMP) IN LONG EVANS RATS.

    TMP (2,2,4-trimethylpentane,“isooctane”) is a colorless liquid used primarily in the alkylation of isobutene and butylene reactions to derive high-octane fuels. TMP is released in the environment through the manufacture, use, and disposal of products associated with the gasoline ...

  1. 25 CFR 224.161 - How may reassumption affect the tribe's ability to enter into a new TERA or to modify another...

    2010-04-01

    ... into a new TERA or to modify another TERA to administer additional activities or to assume... Reassume § 224.161 How may reassumption affect the tribe's ability to enter into a new TERA or to modify another TERA to administer additional activities or to assume administration of activities that...

  2. Corrective Action Decision Document for Corrective Action Unit 224: Decon Pad and Septic Systems Nevada Test Site, Nevada, Rev. No.: 0

    David A. Strand

    2005-05-01

    This Corrective Action Decision Document has been prepared for Corrective Action Unit (CAU) 224, Decon Pad and Septic Systems, in Areas 2, 3, 5, 6, 11, and 23 of the Nevada Test Site, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective Action Unit 224 is comprised of the following corrective action sites (CASs): (1) 02-04-01, Septic Tank (Buried); (2) 03-05-01, Leachfield; (3) 05-04-01, Septic Tanks (4)/Discharge Area; (4) 06-03-01, Sewage Lagoons (3); (5) 06-05-01, Leachfield; (6) 06-17-04, Decon Pad and Wastewater Catch; (7) 06-23-01, Decon Pad Discharge Piping; (8) 11-04-01, Sewage Lagoon; and (9) 23-05-02, Leachfield. The purpose of this Corrective Action Decision Document is to identify and provide the rationale for the recommendation of a corrective action alternative for the nine CASs within CAU 224. Corrective action investigation activities were performed from August 10, 2004, through January 18, 2005, as set forth in the CAU 224 Corrective Action Investigation Plan.

  3. Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.

    Clint L Miller

    2014-03-01

    Full Text Available Genome-wide association studies (GWAS have identified chromosomal loci that affect risk of coronary heart disease (CHD independent of classical risk factors. One such association signal has been identified at 6q23.2 in both Caucasians and East Asians. The lead CHD-associated polymorphism in this region, rs12190287, resides in the 3' untranslated region (3'-UTR of TCF21, a basic-helix-loop-helix transcription factor, and is predicted to alter the seed binding sequence for miR-224. Allelic imbalance studies in circulating leukocytes and human coronary artery smooth muscle cells (HCASMC showed significant imbalance of the TCF21 transcript that correlated with genotype at rs12190287, consistent with this variant contributing to allele-specific expression differences. 3' UTR reporter gene transfection studies in HCASMC showed that the disease-associated C allele has reduced expression compared to the protective G allele. Kinetic analyses in vitro revealed faster RNA-RNA complex formation and greater binding of miR-224 with the TCF21 C allelic transcript. In addition, in vitro probing with Pb2+ and RNase T1 revealed structural differences between the TCF21 variants in proximity of the rs12190287 variant, which are predicted to provide greater access to the C allele for miR-224 binding. miR-224 and TCF21 expression levels were anti-correlated in HCASMC, and miR-224 modulates the transcriptional response of TCF21 to transforming growth factor-β (TGF-β and platelet derived growth factor (PDGF signaling in an allele-specific manner. Lastly, miR-224 and TCF21 were localized in human coronary artery lesions and anti-correlated during atherosclerosis. Together, these data suggest that miR-224 interaction with the TCF21 transcript contributes to allelic imbalance of this gene, thus partly explaining the genetic risk for coronary heart disease associated at 6q23.2. These studies implicating rs12190287 in the miRNA-dependent regulation of TCF21, in

  4. Role of the conserved arginine 274 and histidine 224 and 228 residues in the NuoCD subunit of complex I from Escherichia coli.

    Belevich, Galina; Euro, Liliya; Wikström, Mårten; Verkhovskaya, Marina

    2007-01-16

    The conserved arginine 274 and histidine 224 and 228 residues in subunit NuoCD of complex I from Escherichia coli were substituted for alanine. The wild-type and mutated NuoCD subunit was expressed on a plasmid in an E. coli strain bearing a nuoCD deletion. Complex I was fully expressed in the H224A and H228A mutants, whereas the R274A mutation yielded approximately 50% expression. Ubiquinone reductase activity of complex I was studied in membranes and with purified enzyme and was 50% and 30% of the wild-type activity in the H224A and H228A mutants, respectively. The activity of R274A was less than 5% of the wild type in membranes but 20% in purified complex I. Rolliniastatin inhibited quinone reductase activity in the mutants with similar affinity as in the wild type, indicating that the quinone-binding site was not significantly altered by the mutations. Ubiquinone-dependent superoxide production by complex I was similar to the wild type in the R274A mutant but slightly higher in the H224A and H228A mutants. The EPR spectra of purified complex I from the H224A and H228A mutants did not differ from the wild type. In contrast, the signals of the N2 cluster and another fast-relaxing [4Fe-4S] cluster, tentatively assigned as N6b, were drastically decreased in the NADH-reduced R274A mutant enzyme but reappeared on further reduction with dithionite. These findings show that the redox potential of the N2 and N6b centers is shifted to more negative values by the R274A mutation. Purified complex I was reconstituted into liposomes, and electric potential was generated across the membrane upon NADH addition in all three mutant enzymes, suggesting that none of the mutations directly affect the proton-pumping machinery.

  5. Scintigraphic, radiological and clinical results after /sup 224/Ra therapy in patients with Bechterew's disease

    Redecker, S.; Crone-Muenzebrock, W.; Weh, L.; Montz, R. (Hamburg Univ. (Germany, F.R.))

    1982-04-01

    53 patients with ancylosing spondylitis (clinical stages II and III) were treated with 1 MBq Ra 224 over a period of ten weeks. In 44 patients the orthopaedic findings were improved, in 9 patients they remained unchanged. An iridocyclitis developed in 3 patients, in 1 case an uveitis could be observed 33 patients were reexamined clinically, radiologically including total body scan and by laboratory means after an average period of 7.1 years. The stiftness of the spine was slightly improved compared with the pre-therapeutical status. Radiologically the spine findings were unchanged in 7 patients, progradient in 16, and clearly deteriorated in 8 cases. Scintiscanning of the skeleton of 21 patients showed a normal activity in 6 patients, 8 patients had a slight increase of the activity, mainly in the sacroiliac region 7 patients revealed a highly increased activity in the sacro-iliac region and lumbovertebral spine. Differential blood count and electrophoresis were unchanged before and after therapy. In 60% of the cases the erythrocyte sedimentation rate was diminished compared with pretherapy findings, in 40% the rate was unchanged or increased. Subjectively 10% of the patients reported no pain symptoms, 50% felt better, 30% were unchanged and 10% felt more poorly than before.

  6. Dimer of Bis[trans-5-methyl-2-[2-(4-methoxylphenyl) ethenyl]-benzoxazole]di-μ-nitratosilver(I)

    LIU Hui-Min; ZHANG Wei; XIN Ying; ZHANG Wen-Qin

    2004-01-01

    The title complex [AgNO3(C17H15NO2)2]2 was synthesized and characterized by X-ray diffraction analysis. The compound crystallizes in triclinic, space group Pī with a = 11.226(7), b = 11.906(7), c = 12.144(7) (A。), α = 99.796(10), β = 91.631(10), γ = 101.225(10)°, V = 1565.6(16)(A。)3, Z = 1, Mr = 1400.96, Dc = 1.486 g/cm3, F(000) = 716 and μ(Mo-Kα) = 0.697 mm-1. The final R and wR are 0.0401 and 0.0995, respectively for 5492 independent observable reflections with I > 2σ(I). The results show that the central Ag atom is four-coordinated with two O atoms from two distinct NO3- anions and two N atoms from two trans-5-methyl-2-[2-(4-methoxylphenyl)ethenyl]- benzoxazole ligands, and the two Ag atoms bridged with two O atoms give an interesting Ag-O-Ag-O parallelogram structure. The coordination sphere of Ag atom exhibits a heavily distorted tetrahedral geometry and the coordination angles lie in the range of 66.73(12)~129.59(10)°. The intra- molecular dihedral angles between the benzoxazolyl and phenyl planes are 4.1(3) and 2.9(3)°, respectively.

  7. 鞍区肿瘤的脑电图特征(附224例分析)%The EEG of sella turcica region tumor: an analysis of 224 cases

    吴维华; 吴萍嘉

    1999-01-01

    目的:探索鞍区肿瘤的脑电图(EEG)特征.方法:224例经手术和(或)病理、CT、MRI证实的鞍区肿瘤分成3组:(1)垂体腺瘤组153例;(2)颅咽管瘤组46例;(3)鞍区其他肿瘤组25例.所有患者均按常规方法在手术前2~30 d内记录EEG.结果:过半数的患者(57.6%)呈现正常或轻度异常EEG,其余患者(42.4%)表现EEG异常,其中弥漫性异常29.0%,阵发性异常8.5%,局灶性异常4.9%.此外,有24例(10.7%)出现间歇性节律性δ活动(IRDA),77例(34.4%)有生理波抑制现象.IRDA及生理波抑制在颅咽管瘤组中的出现率明显高于其他两组.直径>20 mm的鞍区肿瘤EEG异常率高.结论:鞍区肿瘤的EEG以无特征性改变占主导地位,其EEG异常的主要表现形式是弥漫性及阵发性异常,少有局灶性异常出现.肿瘤体积与异常程度呈正相关.EEG对鞍区肿瘤的定性诊断有一定帮助.

  8. 爱特梅尔maXTouch mXT224E助力三星Galaxy S II智能手机触摸屏

    2011-01-01

    微控制器及触摸解决方案的领导厂商爱特梅尔公司(Atmel)宣布三星公司(Samsung)已经选择爱特梅尔maXTouch mXT224E控制器来助力其新一代Galaxy SII触摸屏。mXT224E是全新maXTouch E-系列中的一员.具有先进的噪声抑制功能.可以实现更薄的触摸屏配置.如”外挂式”(on-celf,触摸传感器图形设置于显示面板上)配置设计。

  9. Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria.

    Wattana-Amorn, Pakorn; Charoenwongsa, Waranya; Williams, Christopher; Crump, Matthew P; Apichaisataienchote, Busaya

    2016-09-01

    Two bioactive cyclic dipeptides, cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr), were isolated from the culture broth of Streptomyces sp. strain 22-4 and tested against three economically important plant pathogens, Xanthomonas axonopodis pv. citri, Ralstonia solanacearum and Clavibacter michiganensis. Both cyclic dipeptides were active against X. axonopodis pv. citri and R. Solanacearum with MIC of 31.25 μg/mL. No activity could be observed against C. michiganensis.

  10. Densities, viscosities, refractive indices, and surface tensions for binary and ternary mixtures of 2-propanol, tetrahydropyran, and 2,2,4-trimethylpentane

    Kao, Y.-C. [Department of Applied Chemistry, Providence University, Shalu 43301, Taiwan (China); Tu, C.-H., E-mail: chtu@pu.edu.t [Department of Applied Chemistry, Providence University, Shalu 43301, Taiwan (China)

    2011-02-15

    Densities, viscosities, refractive indices, and surface tensions of the ternary system (2-propanol + tetrahydropyran + 2,2,4-trimethylpentane) at T = 303.15 K and its constituent binary systems (2-propanol + tetrahydropyran, 2-propanol + 2,2,4-trimethylpentane, and tetrahydropyran + 2,2,4-trimethylpentane) at T = (293.15, 303.15, 313.15, and 323.15) K were measured at atmospheric pressure. Densities were determined using a vibrating-tube densimeter. Viscosities were measured with an automatic microviscometer based on the rolling-ball principle. Refractive indexes were measured using a digital Abbe-type refractometer. Surface tensions were determined by the Wilhelmy-plate method. From these data, excess molar volumes, deviations in viscosity, deviations in refractive index, and deviations in surface tension were calculated. The results for the binary and ternary systems were fitted to the Redlich-Kister equation and the variable-degree polynomials in terms of compositions, respectively. The experimental and calculated quantities are used to study the nature of mixing behaviour between mixture components.

  11. Comment: 224 [Taxonomy Icon

    Full Text Available ty of Tokyo) licensed under CC Attribution2.1 Japan ヨコヅナクマムシ 光学顕微鏡写真 撮影:國枝武和(東京大学) bando 2010/02/15 14:55:40 2010/02/16 10:42:46 ...

  12. Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian Adaptation.

    Song, Jiasheng; Xu, Jing; Shi, Jianzhong; Li, Yanbing; Chen, Hualan

    2015-05-22

    The adaptation of H5N1 avian influenza viruses to human poses a great threat to public health. Previous studies indicate the adaptive mutations in viral polymerase of avian influenza viruses are major contributors in overcoming the host species barrier, with the majority of mammalian adaptive mutations occurring in the PB2 protein. However, the adaptive mutations in the PA protein of the H5N1 avian influenza virus are less defined and poorly understood. In this study, we identified the synergistic effect of the PA/224P + 383D of H5N1 avian influenza viruses and its ability to enhance the pathogenicity and viral replication in a mammalian mouse model. Interestingly, the signature of PA/224P + 383D mainly exists in mammalian isolates of the H5N1 influenza virus and pdmH1N1 influenza virus, providing a potential pathway for the natural adaptation to mammals which imply the effects of natural adaptation to mammals. Notably, the mutation of PA/383D, which is highly conserved in avian influenza viruses, increases the polymerase activity in both avian and human cells, and may have roles in maintaining the avian influenza virus in their avian reservoirs, and jumping species to infect humans.

  13. High sensitivity measurement of 224Ra and 226Ra in water with an improved hydrous titanium oxide technique at the Sudbury Neutrino Observatory

    Aharmim, B; Dai, X; Doucas, G; Farine, J; Fergani, H; Ford, R; Hahn, R L; Hallman, E D; Jelley, N A; Lange, R; Majerus, S; Mifflin, C; Noble, A J; O'Keeffe, H M; Rodriguez-Jimenez, R; Sinclair, D; Yeh, M

    2008-01-01

    The existing hydrous titanium oxide (HTiO) technique for the measurement of 224Ra and 226Ra in the water at the Sudbury Neutrino Observatory (SNO) has been changed to make it faster and less sensitive to trace impurities in the HTiO eluate. Using HTiO-loaded filters followed by cation exchange adsorption and HTiO co-precipitation, Ra isotopes from 200-450 tonnes of heavy water can be extracted and concentrated into a single sample of a few millilitres with a total chemical efficiency of 50%. Combined with beta-alpha coincidence counting, this method is capable of measuring 2.0x10^3 uBq/kg of 224Ra and 3.7x10^3 uBq/kg of 226Ra from the 232Th and 238U decay chains, respectively, for a 275 tonne D2O assay, which are equivalent to 5x10^16 g Th/g and 3x10^16 g U/g in heavy water.

  14. Optical variability of the BL Lacertae object GC 0109+224. Multiband behaviour and time scales from a 7-years monitoring campaign

    Ciprini, S; Raiteri, C M; Villata, M; Ibrahimov, M A; Nucciarelli, G; Lanteri, L

    2003-01-01

    We present the most continuous data base of optical $BVR_{c}I_{c}$ observations ever published on the BL Lacertae object GC 0109+224, collected mainly by the robotic telescope of the Perugia University Observatory in the period November 1994-February 2002. These observations have been complemented by data from the Torino Observatory, collected in the period July 1995-January 1999, and Mt. Maidanak Observatory (December 2000). GC 0109+224 showed rapid optical variations and six major outbursts were observed at the beginning and end of 1996, in fall 1998, at the beginning and at the end of 2000, and at the beginning of 2002. Fast and large-amplitude drops characterized its flux behaviour. The $R_c$ magnitude ranged from 13.3 (16.16 mJy) to 16.46 (0.8 mJy), with a mean value of 14.9 (3.38 mJy). In the periods where we collected multi-filter observations, we analyzed colour and spectral indexes, and the variability patterns during some flares. The long-term behaviour seems approximatively achromatic, but during s...

  15. Determination of gross alpha, 224Ra, 226Ra, and 228Ra activities in drinking water using a single sample preparation procedure.

    Parsa, Bahman; Obed, Reynaldo N; Nemeth, William K; Suozzo, Gail P

    2005-12-01

    The current federal and New Jersey State regulations have greatly increased the number of gross alpha and radium tests for public and private drinking water supplies. The determination of radium isotopes in water generally involves lengthy and complicated processes. In this study, a new approach is presented for the determination of gross alpha, 224Ra, 226Ra, and 228Ra activities in water samples. The method includes a single sample preparation procedure followed by alpha counting and gamma-ray spectroscopy. The sample preparation technique incorporates an EPA-approved co-precipitation methodology for gross alpha determination with a few alterations and improvements. Using 3-L aliquots of sample, spiked with 133Ba tracer, the alpha-emitting radionuclides are isolated by a BaSO4 and Fe(OH)3 co-precipitation scheme. First the gross alpha-particle activity of the sample is measured with a low-background gas-flow proportional counter, followed by radium isotopes assay by gamma-ray spectroscopy, using the same prepared sample. Gamma-ray determination of 133Ba tracer is used to assess the radium chemical recovery. The 224Ra, 226Ra, and 228Ra activities in the sample are measured through their gamma-ray-emitting decay products, 212Pb, 214Pb/214Bi, and 228Ac, respectively. In cases where 224Ra determination is required, the gamma-ray counting should be performed within 2-4 d from sample collection. To measure 226Ra activity in the sample, the gamma-ray spectroscopy can be repeated 21 d after sample preparation to ensure that 226Ra and its progeny have reached the equilibrium state. At this point, the 228Ac equilibration with parent 228Ra is already established. Analysis of aliquots of de-ionized water spiked with NIST-traceable 230Th, 224Ra, 226Ra, and 228Ra standards demonstrated the accuracy and precision of this method. Various performance evaluation samples were also assayed for gross alpha as well as radium isotope activity determination using this procedure and the

  16. Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24.

    Galina I Botchkina

    Full Text Available BACKGROUND: Prostate cancer is the second leading cause of cancer death among men. Multiple evidence suggests that a population of tumor-initiating, or cancer stem cells (CSCs is responsible for cancer development and exceptional drug resistance, representing a highly important therapeutic target. The present study evaluated CSC-specific alterations induced by new-generation taxoid SBT-1214 and a novel polyenolic zinc-binding curcuminoid, CMC2.24, in prostate CSCs. PRINCIPAL FINDINGS: The CD133(high/CD44(high phenotype was isolated from spontaneously immortalized patient-derived PPT2 cells and highly metastatic PC3MM2 cells. Weekly treatment of the NOD/SCID mice bearing PPT2- and PC3MM3-induced tumors with the SBT-1214 led to dramatic suppression of tumor growth. Four of six PPT2 and 3 of 6 PC3MM2 tumors have shown the absence of viable cells in residual tumors. In vitro, SBT-1214 (100 nM-1 µM; for 72 hr induced about 60% cell death in CD133(high/CD44(+/high cells cultured on collagen I in stem cell medium (in contrast, the same doses of paclitaxel increased proliferation of these cells. The cytotoxic effects were increased when SBT-1214 was combined with the CMC2.24. A stem cell-specific PCR array assay revealed that this drug combination mediated massive inhibition of multiple constitutively up-regulated stem cell-related genes, including key pluripotency transcription factors. Importantly, this drug combination induced expression of p21 and p53, which were absent in CD133(high/CD44(high cells. Viable cells that survived this treatment regimen were no longer able to induce secondary spheroids, exhibited significant morphological abnormalities and died in 2-5 days. CONCLUSIONS: We report here that the SBT-1214 alone, or in combination with CMC2.24, possesses significant activity against prostate CD133(high/CD44(+/high tumor-initiating cells. This drug combination efficiently inhibits expression of the majority of stem cell-related genes and

  17. The Formation of 2,2,4-Trimethyl-2,3-dihydro-1H-1,5-Benzodiazepine from 1,2-Diaminobenzene in the Presence of Acetone

    Felix Odame

    2013-11-01

    Full Text Available In an attempt to synthesize a 2-substituted benzimidazole from the reaction of o-phenylenediamine and isophthalic acid in the presence of acetone and ethanol under microwave irradiation, a salt of the isophthalate ion and 2,2,4-trimethyl-2,3-dihydro-1H-1,5-benzodiazepin-5-ium ion was obtained. The condensation of two moles of acetone with the amine groups resulted in the formation of the benzodiazepine which crystallized as an iminium cation forming a salt with the isophthalate anion. The formation of benzodiazepine was also confirmed by performing the reaction of o-phenylenediamine with excess acetone in ethanol under conventional heating conditions. The compounds were characterized by NMR, FTIR, HRMS and microanalysis as well as X-ray crystallography. The reaction mechanism leading to the formation of benzodiazepine is also discussed.

  18. Tris(2-{[2-(4-meth-oxy-phen-yl)eth-yl]imino-meth-yl}phenolato-κ(2)N,O(1))cobalt(III).

    Ourari, Ali; Ouennoughi, Yasmina; Bouacida, Sofiane

    2012-06-01

    In the title compound, [Co(C(16)H(16)NO(2))(3)], the Co(III) atom is six-coordinated in an irregular octa-hedral geometry by three N,O-chelating 2-{[2-(4-meth-oxy-phen-yl)eth-yl]imino-meth-yl}phenolate groups. One of the three meth-oxy group is disordered over two sets of sites with an occupancy ratio of 0.768 (5):0.232 (5). The crystal packing can be described by alternating zigzag layers of organic ligands and CoN(3)O(3) octa-hedra along the c axis. There are no classical hydrogen bonds in the structure, but C-H⋯π inter-actions occur.

  19. Mass spectral characteristics of the chlorinated disinfection byproduct 2,2,4-trichloro-5-methoxy-cyclopent-4-ene-1,3-dione

    Gong, Huijuan; Bao, Yanchu; Yang, Jihong; Jiang, Qin; Chen, Zezhi

    2010-06-01

    The objective of this paper was to correct the mistakes of a previous interpretation of electron impact ionization (EI) mass spectrum of the chlorinated disinfection byproduct (DBP) in drinking water naming 2,2,4-trichloro-5-methoxy-cyclopent-4-ene-1,3-dione (TCMCD). Moreover the positive-ion chemical ionization (CI +) and electrospray ionization (ESI +) mass spectra were also studied. As the search of new chlorinated disinfection byproducts in drinking water is a challenge and researchers generally have to attempt to identify unknown chlorinated products generated from incompletely defined starting materials, fully understanding the mass spectra of this compound may do some help for the analysis of other unknown chlorinated disinfection byproducts.

  20. Corrective Action Investigation Plan for Corrective Action Unit 224: Decon Pad and Septic Systems Nevada Test Site, Nevada, Rev. No.: 0, with ROTC 1 and 2

    David A. Strand

    2004-04-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 224: Decon Pad and Septic Systems, Nevada Test Site (NTS), Nevada. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense (DoD). The NTS is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Unit 224 is comprised of the nine Corrective Action Sites (CASs) listed below: 02-04-01, Septic Tank (Buried); 03-05-01, Leachfield; 05-04-01, Septic Tanks (4)/Discharge Area; 06-03-01, Sewage Lagoons (3); 06-05-01, Leachfield; 06-17-04, Decon Pad and Wastewater Catch; 06-23-01, Decon Pad Discharge Piping; 11-04-01, Sewage Lagoon; and 23-05-02, Leachfield. Corrective Action Sites 06-05-01, 06-23-01, and 23-05-02 were identified in the 1991 Reynolds Electrical & Engineering Co., Inc. (REECo) inventory (1991). The remaining sites were identified during review of various historical documents. Additional information will be obtained by conducting a corrective action investigation (CAI) prior to evaluating and selecting a corrective action alternative for each CAS. The CAI will include field inspections, radiological and geological surveys, and sample collection. Data will also be obtained to support investigation-derived waste (IDW) disposal and potential future waste management decisions.

  1. A review of oceanographic and meteorological controls on the North Sea circulation and hydrodynamics with a view to the fate of North Sea methane from well site 22/4b and other seabed sources

    Nauw, J.; de Haas, H.; Rehder, G.

    2015-01-01

    The North Sea hydrodynamics are key to the redistribution of methane released at the 22/4b Site, locatedat (57?550N, 1?380E) in the UK Central North Sea, 200 km east of the Scottish mainland. This reviewsummarizes the current state of knowledge on the North Sea circulation, stratification, and varia

  2. 228Ra, 226Ra, 224Ra and 223Ra in potential sources and sinks of land-derived material in the German Bight of the North Sea: implications for the use of radium as a tracer

    Schmidt, C.; Hanfland, C.; Regnier, P.; Van Cappellen, P.; Schlüter, M.; Knauthe, U.; Stimac, I.; Geibert, W.

    2011-01-01

    Activities of the naturally occurring radium nuclides 228Ra, 226Ra, 224Ra and 223Ra were determined in waters of the open German Bight and adjacent nearshore areas in the North Sea, in order to explore the potential use of radium isotopes as natural tracers of land–ocean interaction in an environmen

  3. 球形节杆菌C224分批发酵2-酮基-D-葡萄糖酸的条件优化及其动力学模型的构建%Optimization of 2-keto-D-gluconic acid batch fermentation by Arthrobacter globiformis C224 and its kinetics

    孙文敬; 高培玲; 魏转; 崔凤杰; 周延政; 滕文华; 刘敬泽

    2013-01-01

    In the present study,the operation parameters including aeration rate and initial glucose concentration during 50-L batch fermentation were optimized to increase the 2-keto-D-gluconic acid (2KGA) productivity from rice starch hydrolysate by Arthrobacter globiformis C224.The kinetic models for describing the cell growth,2KGA production and glucose consumption were proposed by using Logistic/Luedeking-Piret equations and mass balance calculation.Results showed that the 2KGA yield decreased slightly and its productivity lowered significantly when the aeration rate was below 1.5 v · v-1 · m-1 The initial glucose concentrations varying from 120.0 g/L to 180.0 g/L were optimal.Under the optimized conditions,the productivities and yields reached to 6.36 ~6.54 g/(L · h) and 0.96 ~0.97 g/g,respectively.Those proposed models could fit the predictive values well with the obtained experimental data.The determination coefficients (R2) of all models were over 0.95,which also indicated that theses models could elucidate the 2KGA metabolic characteristics of Arthrobacter globiformis C224.%通过优化发酵条件,提高球形节杆菌C224菌株利用大米淀粉水解糖分批发酵2-酮基-D-葡萄糖酸的生产强度,并在此基础上构建其发酵动力学模型.在50 L的发酵罐上考察了通气量与葡萄耱浓度对2-酮基-D-葡萄糖酸发酵的影响,并基于Logistic方程、Luedeking-Piret方程和物料平衡计算分别构建了菌体生长、产物形成和底物消耗的动力学模型.研究结果表明,通气量低于1.5 v·v-1·m-1时,发酵生产强度明显减小,糖酸转化率有所降低;发酵培养基中的葡萄糖浓度以120.0~180.0 g/L为宜,过高或过低对生产强度和糖酸转化率均有不利影响.在适宜的发酵条件下,球形节杆菌C224菌株分批发酵生产2-酮基-D-葡萄糖酸的生产强度达6.36~6.54 g/(L h),糖酸转化率为0.96 ~ 0.97 g/g.所构建动力学模型的计算值与实验值拟合效果

  4. Isolation of Actinium from Neutron-irradiated Thorium-I

    1994-01-01

    Isolation of Actinium from Neutron-irradiated Thorium-I¥YangWeifan;YuanShuanggui;MuWantong;ZhangXueqian;LiZhongweiandZhaoLili...

  5. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  6. 2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice.

    Zhu, Zhiyuan; Li, Chenjing; Wang, Xu; Yang, Zhengyi; Chen, Jing; Hu, Lihong; Jiang, Hualiang; Shen, Xu

    2010-07-01

    Alzheimer's disease (AD) characterizes a progressive neurodegenerative disorder of the brain, while AD patients are afflicted with irreversible loss of neurons and further the intellectual abilities including memory and reasoning. One of the typical hallmarks of AD is the deposition of senile plaque that is contributed mainly by amyloid-beta (Abeta), whose production is initiated by beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1). Inhibition of BACE1 is thereby regarded as an attractive strategy for anti-AD drug discovery. Here, we reported that the natural product 2,2',4'-trihydroxychalcone (TDC) from Glycyrrhiza glabra functioned as a specific non-competitive inhibitor against BACE1 enzyme, and potently repressed beta-cleavage of APP and production of Abeta in human embryo kidney cells-APPswe cells. Moreover, the amelioration ability of this compound against the in vivo memory impairment was further evaluated by APP-PS1 double transgenic mice model. It is discovered that treatment of 9 mg/kg/day of TDC could obviously decrease Abeta production and Abeta plaque formation, while efficiently improve the memory impairment based on Morris water maze test. Our findings thus demonstrated that the natural product TDC as a new BACE1 inhibitor could ameliorate memory impairment in mice, and is expected to be potentially used as a lead compound for further anti-AD reagent development.

  7. Cessation of dangerousness status: an analysis of 224 reports from the Instituto de Perícias Heitor Carrilho, Rio de Janeiro, Brazil

    Gustavo C. Oliveira

    Full Text Available Objectives: To evaluate factors related to dangerousness cessation at the end of involuntary commitment based on an analysis of expert reports. In light of the current legal requirement of dangerousness cessation as a pre-requisite for prison or internment release of individuals subjected to the safety measure, we sought elements to reflect on the practice of expert examiners in charge of making this decision. Methods: The authors revised 224 expert psychiatric dangerousness cessation reports released 2011 through 2014 and collected data for a statistical analysis. Results: The following variables were associated with positive risk cessation assessments: no inadequate behavior (according to the assistant professionals, no productive psychotic symptoms, no negative symptoms, presence of insight, presence of a support network, and no psychoactive substance abuse. The following variables were associated with negative dangerousness cessation decisions: early onset of malfunction, lack of insight, negative attitudes, active signs of major mental illness, presence of impulsiveness, poor response to treatment, presence of plans lacking feasibility, exposure to destabilizing factors, lack of personal support, and presence of stress. Conclusions: In this study we were able to identify factors associated with dangerousness in a sample of expert reports. The knowledge of factors linked to a higher risk of recidivism in illegal activities or violent behavior is crucial for decision-making regarding the release of offenders after their legally established period of involuntary commitment.

  8. Growth and characterization of an organic single crystal: 2-[2-(4-Diethylamino-phenyl)-vinyl]-1-methyl-pyridinium iodide

    Senthil, K.; Kalainathan, S.; Ruban Kumar, A.

    Optically transparent crystal of the organic salt DEASI (2-[2-(4-Diethylamino-phenyl)-vinyl]-1-methyl-pyridinium iodide) has been synthesized by using knoevenagel condensation reaction method. The synthesized material has been purified by successfully recrystallization process. Single crystals of DEASI have been grown by slow evaporation technique at room temperature. The solubility of the title material has been determined at different temperature in acetonitrile/methanol mixture. The cell parameters and crystallinity of the title crystal were determined by single crystal XRD. The powder diffraction was carried out to study the reflection plane of the grown crystal and diffraction peaks were indexed. The presence of different functional groups in the crystal was confirmed by Fourier transform infrared (FTIR) analysis. 1H NMR spectrum was recorded to confirm the presence of hydrogen nuclei in the synthesized material. The optical property of the title crystal was studied by UV-Vis-NIR spectroscopic analysis. The melting point and thermal property of DEASI were studied using TGA/DSC technique. The Vicker’s hardness (Hv) was carried out to know the category. The dielectric constant and dielectric loss of the compound decreases with an increase in frequencies. Chemical etching studies showed that the DEASI grows in the two dimensional growth mechanisms. The Kurtz-Perry powder second harmonic generation (SHG) test has done for title crystal.

  9. Spectroscopic studies on 2-[2-(4-methylquinolin-2-yl)hydrazono]-1,2-diphenylethanone molecule and its metal complexes

    Seleem, H. S.; El-Inany, G. A.; Mousa, M.; Hanafy, F. I.

    2009-11-01

    The electronic absorption spectra of a hydrazone: 2-[2-(4-methylquinolin-2-yl)hydrazono]-1,2-diphenylethanone (BHQ) derived from 2-hydrazino-4-methylquinoline and 1,2-diphenylethan-1,2-dione (benzil) have been studied in various solvents of different polarities. The dependence of the band shift Δ ύ on the solvent parameters viz.D, Z, ET, DN, AN, α, β and π* was discussed. Also, the effect of pH on the free hydrazone and its Co(II), Ni(II) and Cu(II) complexes was studied spectrophotometrically in 75% (v/v) dioxane-water in order to determine the dissociation and stability constants. The stoichiometry of the formed complexes was determined by three different methods: Job's, mole ratio and slope ratio which indicate the formation of 1:2, M:L complexes for Co(II) and Cu(II) and 1:1, Ni(II):L. Beer's law is valid in the range 0.32-7.04 μg/mL depending on the type of the metal ion. The use of BHQ as an indicator via a spectrophotometric titration of Cu(II) and Ni(II) with EDTA was efficient.

  10. Preparation and electrical properties of FexCu0.10Ni0.66Mn2.24−xO4 (0 ≤ x ≤ 0.90) NTC ceramics

    Fang, Dao-lai; Chen, Chu-Sheng; Winnubst, A.J.A.

    2008-01-01

    In this paper, the dense FexCu0.10Ni0.66Mn2.24−xO4 (0 ≤ x ≤ 0.90) ceramics with accurate stoichiometry are prepared by the route of solid-state coordination reaction. The effect of Fe addition on the electrical properties of the ceramics has been investigated by powder X-ray diffraction (XRD), elec

  11. Seasonal variability of the meridional overturning circulation in the South China Sea and its connection with inter-ocean transport based on SODA2.2.4

    Zhu, Yaohua; Fang, Guohong; Wei, Zexun; Wang, Yonggang; Teng, Fei; Qu, Tangdong

    2016-05-01

    We have proposed a five-layer-scheme to investigate the volume transport through the South China Sea (SCS) based on the updated Simple Ocean Data Assimilation (SODA2.2.4) product. By demonstrating horizontal transport in each layer, we have revealed different formation mechanisms for the meridional overturning circulation (MOC) in winter and summer in the SCS. Our analysis suggests three meridional circulation systems in the SCS: (1) the seasonal monsoon-driven circulation in the surface layer, i.e., southward circulation in winter and northward in summer, (2) the compensatory transport-induced seasonal intermediate MOC in the central SCS, and (3) the persistent deep MOC in the southern SCS all year round. By examining vertical velocity distribution, we have identified that the major overturning process of the intermediate MOC is located along the continental slope east and southeast of Vietnam, while the major overturning process of the deep MOC is located along the continental slope northwest of Borneo. The downwelling in the intermediate MOC in winter and upwelling in the deep MOC all year round bring different water masses to the intermediate and subintermediate layers to be mixed in the SCS. We found no evidence to suggest that the strength and extent of the MOC south of 18°N are related to inter-ocean volume transport. The surface layer transport in the Luzon Strait has been decreasing since the 1960s. However, the causes of the meridionally staggered and interdecadal alternating acceleration/slowdown of the meridional stream function difference are unknown.

  12. Letter Report to Address Comments on the Closure Report for Corrective Action Unit 224: Decon Pad and Septic Systems, Nevada Test Site, Nevada, Revision 0, March 2008

    NSTec Environmental Restoration

    2008-03-17

    The Closure Report (CR) for Corrective Action Unit (CAU) 224, Decon Pad and Septic Systems, was approved by the Nevada Department of Environmental Protection (NDEP) on November 01, 2007. The approval letter contained the following two comments: Comment 1--For 06-05-01, 06-17-04, 06-23-01 provide evidence that the 6 inch VCP pipe originating from building CP-2 is no longer active and sealed to prevent possible future contamination. Comment 2--For the area that includes 06-03-01, provide evidence that active lines are no longer feeding the North and South lagoons and have been sealed to prevent possible future contamination. To address these comments, closure documentation was reviewed, and site visits were conducted to locate and document the areas of concern. Additional fieldwork was conducted in March 2008 to seal the lines and openings described in the two comments. Photographs were taken of the closed drains and lines to document that the NDEP comments were adequately addressed and potential inadvertent discharge to the environment has been eliminated. Investigation and closure documentation was reviewed to identify the locations of potential drains, lines, and other features that could receive and/or transmit liquid. Based on the investigation findings and subsequent closure activities, no openings, distribution boxes, or other features (excluding known floor drains at CP-2) that could receive liquid were found at the CP-2 location (Figure 1), and potential manholes for the north and south sewage lagoons were identified for Corrective Action Site (CAS) 06-03-01 (Figure 2). The distribution box identified in Figure 1 was not located during the investigation and was assumed to have been previously removed.

  13. Effect of 2-amino-2-[2-(4-octylphenyl) ethyl] propane-1,3-diol hydrochloride (FTY 720) on immune liver injury in mice

    Jing-Hua He; Hui-Na Zhang; Zhi-Bin Lin

    2005-01-01

    AIM: To investigate the protective effect against two immune liver injury models in mice by 2-amino-2-[2-(4-octylphenyl)ethyl] propane-1,3-diol hydrochloride and its possible mechanisms in Con A-induced liver damage.METHODS: Liver tissue or hepatocyte injury was monitored biochemically by measuring alanine aminotransferase (sALT)and aspartate aminotransferase (sAST) activity. Hematoxylin & eosin (HE) staining was used for histopathological examination. To evaluate the role of IFN-γ and IL-4 in the iver injury, serum levels of IFN-γ and IL-4 were determined using commercially available ELISA kit at 12 h after Con A challenge. We also determined FTY 720-induced spleen cell apoptosis by flow cytometry analysis or spleen cell proliferation test.RESULTS: Different doses of FTY 720 treatment dramatically reduced circulating markers of hepatocyte injury in two kinds of immunological liver injury models. FTY 720 dramatically reduced the elevated serum IFN-γ and IL-4 levels after Con A injection. Effect of spleen cell supernatants treated with Con A or FTY 720 on hepatocytes showed that ALT activities in cultured hepatocyte supernatants in Con A treatment group increased markedly and FTY 720 could reduce this elevated ALT activities in FTY 720 treatment group. FTY 720 dose-dependently increased the percentage of apoptotic cells in T cells and inhibited splenocyte proliferation induced by Con A.CONCLUSION: Pretreatment with FTY 720 was shown to produce protective effect on the immune liver injury in mice. The possible mechanism of FTY 720 on Con A-induced liver damage is that it could inhibit lymphocyte proliferation and induce lymphocyte apoptosis, resulting in the reduction of IL-4 or IFN-γ release, and subsequently protecting liver from being damaged by Con A.

  14. Occurrence of Radium-224, Radium-226 and Radium-228 in Water from the Vincentown and Wenonah-Mount Laurel Aquifers, the Englishtown Aquifer System, and the Hornerstown and Red Bank Sands, Southwestern and South-Central New Jersey

    dePaul, Vincent T.; Szabo, Zoltan

    2007-01-01

    This investigation is the first regionally focused study of the presence of natural radioactivity in water from the Vincentown and Wenonah-Mount Laurel aquifers, Englishtown aquifer system, and the Hornerstown and Red Bank Sands. Geologic materials composing the Vincentown and Wenonah-Mount Laurel aquifers and the Hornerstown and Red Bank Sands previously have been reported to contain radioactive (uranium-enriched) phosphatic strata, which is common in deposits from some moderate-depth coastal marine environments. The decay of uranium and thorium gives rise to natural radioactivity and numerous radioactive progeny, including isotopes of radium. Naturally occurring radioactive isotopes, especially those of radium, are of concern because radium is a known human carcinogen and ingestion (especially in water used for drinking) can present appreciable health risks. A regional network in southwestern and south-central New Jersey of 39 wells completed in the Vincentown and Wenonah-Mount Laurel aquifers, the Englishtown aquifer system, and the Hornerstown and Red Bank Sands was sampled for determination of gross alpha-particle activity; concentrations of radium radionuclides, major ions, and selected trace elements; and physical properties. Concentrations of radium-224, radium-226, and radium-228 were determined for water from 28 of the 39 wells, whereas gross alpha-particle activity was determined for all 39. The alpha spectroscopic technique was used to determine concentrations of radium-224, which ranged from less than 0.5 to 2.7 pCi/L with a median concentration of less than 0.5pCi/L, and of radium-226, which ranged from less than 0.5 to 3.2 pCi/L with a median concentration of less than 0.5 pCi/L. The beta-counting technique was used to determine concentrations of radium-228. The concentration of radium-228 ranged from less than 0.5 to 4.3 pCi/L with a median of less than 0.5. Radium-228, when quantifiable, had the greatest concentration of the three radium

  15. 急性 ST 段抬高型心肌梗死224例患者冠脉病变部位程度影响的分析%Analysis for influence of coronary artery lesions position and degree in 224 patients with acute ST eleva-tion myocardial infarction

    陈明光; 关瑞锦; 吴志勇; 林风辉

    2015-01-01

    Objective:To explore influence of position of myocardial infarction and coronary artery lesions in patients with acute ST elevation myocardial infarction (STEMI) ,and the relationship among heart failure ,arrhythmia and severity of coronary artery lesion .Methods :Clinical data of 224 patients ,who hospitalized in our hospital because of STEMI and received coronary angiography from Jan 2009 to Jun 2011 ,were retrospectively analyzed .General data of patients were collected ,and SYNTAX score was used to reflect severity of coronary artery lesion ,and the rela‐tionship among heart failure ,arrhythmia and SYNTAX scores were analyzed .Results:Incidence rate of heart fail‐ure in patients with infarction relate artery left anterior descending artery (LAD) AND/or left main coronary artery (LM) was significantly higher than that of patients with right coronary artery (RCA) (57.0% vs .39.7% , P=0.017) ,incidence rate of arrhythmia in patients with RCA was significantly higher than that of patients with left circumflex artery (LCX) (37.0% vs .6.3% , P=0.016);incidence rates of arrhythmia (48.4% ) ,shock (54.8% ) were highest in patients with inferior wall/right ventricle than those of other position , P<0.05 or <0.01.SYNTAX scores in patients with heart failure and arrhythmia were significantly higher than those of patients without heart failure and arrhythmia respectively [ (18.7 ± 9.1) scores vs .(15.4 ± 8.6) scores ,(19.7 ± 9.0) scores vs .(16.1 ± 8.8) scores , P<0.01 both] .Conclusion:Incidence rates of heart failure ,cardiogenic shock and arrhythmia are related to coronary artery lesions position and degree and myocardial infarction position in STEMI patients .%目的:探讨急性ST段抬高型心肌梗死(STEMI)部位及冠脉病变对心衰、心律失常的影响,以及心衰,心律失常与冠脉病变程度的关系。方法:回顾性分析2009年1月至2011年6月因STEMI于我院住院治疗并行冠脉造影的患者224例的临床资料。

  16. Support vector classification for structure-activity-relationship of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols%支持向量分类算法用于1-(1H-1,2,4-三唑-1-基)-2-(2,4-二氟苯基)-3-取代-2-丙醇化合物的构效关系研究

    纪晓波; 陆文聪; 蔡煜东; 陈念贻

    2007-01-01

    The support vector classification (SVC) was employed to make a model for classification of antifungal activities of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols triazole derivatives. The compounds with high antifungal activities and those with low antifungal activities were compared on the basis of the following molecular descriptors: net atomic charge on the atom N connecting with R, dipole moment and heat of formation. By using the SVC, a mathematical model was constructed, which can predict the antifungal activities of the triazole derivatives, with an accuracy of 91% on the basis of the leave-one-out cross-validation (LOOCV) test. The results indicate that the performance of the SVC model can exceed that of the principal component analysis (PCA) and K-Nearest Neighbor (KNN) models for this real world data set.

  17. Motivos filo-esópicos en el Midrás. Fábulas y anécdotas de rabinos en Levítico Rabbá 22,4

    Miralles Maciá, Lorena

    2009-12-01

    Full Text Available The text of LvR 22:4 collects some fables and the Rabbis’ vital experiences, bringing them together harmoniously. These stories share the same context and theme, because they both are related to the observation of the nature and especially to the world of the animals. Although it is not possible to ascertain whether the origin of the fables lies in the Aesopian tradition, clear parallels are observed between the images of the Midrash and those of the Roman-Hellenistic collections that have come down to us. Therefore, the aim of this study is twofold: on the one hand, to analyse the fables and their links with the Aesopian motifs and, on the other, to offer a valuable example of how these tales are perfectly combined with the Sages’ anecdotes by means of the Rabbinic literary devices.El pasaje de LvR 22,4 combina armoniosamente una serie de fábulas con algunos episodios de la vida de ciertos rabinos. Estos relatos comparten un mismo contexto y una misma temática, ya que están relacionados con la observación de la naturaleza y sobre todo del mundo animal. Aunque no es posible afirmar con seguridad si el origen de las fábulas se halla en las tradiciones esópicas, se observan claros paralelos entre las imágenes del Midrás y las de las colecciones de época helenística-romana que han llegado hasta nuestros días. Por tanto, el presente estudio tiene una doble finalidad: por un lado, el análisis de las fábulas y su vinculación con los motivos esópicos y, por otro, ofrecer un valioso ejemplo de cómo se conjugan estos relatos con las anécdotas de los sabios a través de los recursos propios de la literatura rabínica.

  18. New derivative of 2-(2,4-dihydroxyphenyl)thieno-1,3-thiazin-4-one (BChTT) elicits antiproliferative effect via p38-mediated cell cycle arrest in cancer cells.

    Juszczak, Małgorzata; Walczak, Katarzyna; Matysiak, Joanna; Lemieszek, Marta K; Langner, Ewa; Karpińska, Monika M; Pożarowski, Piotr; Niewiadomy, Andrzej; Rzeski, Wojciech

    2016-03-15

    2-(2,4-Dihydroxyphenyl)thieno-1,3-thiazin-4-ones are a group of new compounds with potential anticancer activity. This type of derivatives was poorly investigated in the area of synthesis and biological activities. In the present study the antiproliferative action of the most active derivative BChTT was described. The aim of biological evaluation was to investigate the ability of the compound to inhibit cancer cell proliferation and identify mechanism involved in its action on the molecular level. BChTT inhibited the proliferation of lung cancer A549, colon cancer HT-29 and glioma C6 cells in the concentration-dependent manner. It was not toxic to normal cells including skin fibroblasts, hepatocytes and oligodendrocytes in the antiproliferative concentrations. BChTT decreased the DNA synthesis in the treated cancer cells and induced cell cycle arrest in the G0/G1 phase. Moreover, the ability of the compound to activate p38 kinase and decrease cyclin D1 expression was estimated. Participation of p38 kinase in the antiproliferative action of the compound was confirmed by the analysis of BChTT activity in the cells with the p38 silenced gene. The obtained results may suggest the ability of the tested derivative to inhibit cancer cells proliferation by induction of p38-mediated cyclin D1 downregulation.

  19. Participant and spectator scaling of spectator fragments in Au + Au and Cu + Cu collisions at √{sN N}=19.6 and 22.4 GeV

    Alver, B.; Back, B. B.; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Budzanowski, A.; Busza, W.; Carroll, A.; Chai, Z.; Chetluru, V.; Decowski, M. P.; García, E.; Gburek, T.; George, N.; Gulbrandsen, K.; Gushue, S.; Halliwell, C.; Hamblen, J.; Harnarine, I.; Heintzelman, G. A.; Henderson, C.; Hofman, D. J.; Hollis, R. S.; Hołyński, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Katzy, J.; Khan, N.; Kucewicz, W.; Kulinich, P.; Kuo, C. M.; Li, W.; Lin, W. T.; Loizides, C.; Manly, S.; McLeod, D.; Mignerey, A. C.; Nouicer, R.; Olszewski, A.; Pak, R.; Park, I. C.; Pernegger, H.; Reed, C.; Remsberg, L. P.; Reuter, M.; Richardson, E.; Roland, C.; Roland, G.; Rosenberg, L.; Sagerer, J.; Sarin, P.; Sawicki, P.; Sedykh, I.; Skulski, W.; Smith, C. E.; Stankiewicz, M. A.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Szostak, A.; Tang, J.-L.; Tonjes, M. B.; Trzupek, A.; Vale, C.; van Nieuwenhuizen, G. J.; Vaurynovich, S. S.; Verdier, R.; Veres, G. I.; Walters, P.; Wenger, E.; Willhelm, D.; Wolfs, F. L. H.; Wosiek, B.; Woźniak, K.; Wuosmaa, A. H.; Wyngaardt, S.; Wysłouch, B.; Phobos Collaboration

    2016-08-01

    Spectator fragments resulting from relativistic heavy ion collisions, consisting of single protons and neutrons along with groups of stable nuclear fragments up to nitrogen (Z =7 ), are measured in PHOBOS. These fragments are observed in Au+Au (√{sNN}=19.6 GeV ) and Cu+Cu (22.4 GeV) collisions at high pseudorapidity (η ). The dominant multiply-charged fragment is the tightly bound helium (α ), with lithium, beryllium, and boron all clearly seen as a function of collision centrality and pseudorapidity. We observe that in Cu+Cu collisions, it becomes much more favorable for the α fragments to be released than lithium. The yields of fragments approximately scale with the number of spectator nucleons, independent of the colliding ion. The shapes of the pseudorapidity distributions of fragments indicate that the average deflection of the fragments away from the beam direction increases for more central collisions. A detailed comparison of the shapes for α and lithium fragments indicates that the centrality dependence of the deflections favors a scaling with the number of participants in the collision.

  20. Participant and spectator scaling of spectator fragments in Au+Au and Cu+Cu collisions at sqrt(sNN) = 19.6 and 22.4 GeV

    Alver, B; Baker, M D; Ballintijn, M; Barton, D S; Betts, R R; Bickley, A A; Bindel, R; Budzanowski, A; Busza, W; Carroll, A; Chai, Z; Chetluru, V; Decowski, M P; Garcia, E; Gburek, T; George, N; Gulbrandsen, K; Gushue, S; Halliwell, C; Hamblen, J; Harnarine, I; Heintzelman, G A; Henderson, C; Hofman, D J; Hollis, R S; Holynski, R; Holzman, B; Iordanova, A; Johnson, E; Kane, J L; Katzy, J; Khan, N; Kucewicz, W; Kulinich, P; Kuo, C M; Li, W; Lin, W T; Loizides, C; Manly, S; McLeod, D; Mignerey, A C; Nouicer, R; Olszewski, A; Pak, R; Park, I C; Pernegger, H; Reed, C; Remsberg, L P; Reuter, M; Richardson, E; Roland, C; Roland, G; Rosenberg, L; Sagerer, J; Sarin, P; Sawicki, P; Sedykh, I; Skulski, W; Smith, C E; Stankiewicz, M A; Steinberg, P; Stephans, G S F; Sukhanov, A; Szostak, A; Tang, J L; Tonjes, M B; Trzupek, A; Vale, C; van Nieuwenhuizen, G J; Vaurynovich, S S; Verdier, R; Veres, G I; Walters, P; Wenger, E; Willhelm, D; Wolfs, F L H; Wosiek, B; Wozniak, K; Wuosmaa, A H; Wyngaardt, S; Wyslouch, B

    2015-01-01

    Spectator fragments resulting from relativistic heavy ion collisions, consisting of single protons and neutrons along with groups of stable nuclear fragments up to Nitrogen (Z=7), are measured in PHOBOS. These fragments are observed in Au+Au (sqrt(sNN)=19.6 GeV) and Cu+Cu (22.4 GeV) collisions at high pseudorapidity ($\\eta$). The dominant multiply-charged fragment is the tightly bound Helium ($\\alpha$), with Lithium, Beryllium, and Boron all clearly seen as a function of collision centrality and pseudorapidity. We observe that in Cu+Cu collisions, it becomes much more favorable for the $\\alpha$ fragments to be released than Lithium. The yields of fragments approximately scale with the number of spectator nucleons, independent of the colliding ion. The shapes of the pseudorapidity distributions of fragments indicate that the average deflection of the fragments away from the beam direction increases for more central collisions. A detailed comparison of the shapes for $\\alpha$ and Lithium fragments indicates tha...

  1. Synthesis, growth, structural, optical, luminescence, surface and HOMO LUMO analysis of 2-[2-(4-cholro-phenyl)-vinyl]-1-methylquinolinium naphthalene-2-sulfonate organic single crystals grown by a slow evaporation technique

    Karthigha, S.; Kalainathan, S.; Maheswara Rao, Kunda Uma; Hamada, Fumio; Yamada, Manabu; Kondo, Yoshihiko

    2016-02-01

    Single crystals of 2-[2-(4-cholro-phenyl)-vinyl]-1-methylquinolinium naphthalene-2-sulfonate (4CLNS) were grown by a slow evaporation technique. The formation of molecule was confirmed from 1H NMR and FTIR analysis. The confirmation of crystal structure was done by single crystal XRD and atomic packing of grown crystal was identified. The grown single crystal crystallized in triclinic structure with centrosymmetric space group P-1. The crystalline nature of the synthesised material was recorded by powder XRD. The optical absorption properties of the grown crystals were analyzed by UV-vis spectral studies. The thermal behaviour of the title material has been studied by TG/DTA analysis which revealed the stability of the compound till its melting point 276.7 °C. The third order nonlinear optical property of 4CLNS was investigated in detail by Z scan technique and it confirms that the title crystal is suitable for photonic devices and NLO optical applications. Emissions at 519 nm in green region of the EM spectrum were found by photoluminescence studies. The charge transfer occurring within the molecule is explained by the calculated HOMO and LUMO energies.

  2. Contiguous 2,2,4-triamino-5(2H)-oxazolone obstructs DNA synthesis by DNA polymerases α, β, η, ι, κ, REV1 and Klenow Fragment exo-, but not by DNA polymerase ζ.

    Suzuki, Masayo; Kino, Katsuhito; Kawada, Taishu; Oyoshi, Takanori; Morikawa, Masayuki; Kobayashi, Takanobu; Miyazawa, Hiroshi

    2016-03-01

    Guanine is the most easily oxidized of the four DNA bases, and contiguous guanines (GG) in a sequence are more readily oxidized than a single guanine in a sequence. Continued oxidation of GGs results in a contiguous oxidized guanine lesion. Two contiguous 2,5-diamino-4H-imidazol-4-ones, an oxidized form of guanine that hydrolyses to 2,2,4-triamino-5(2H)-oxazolone (Oz), are detected following the oxidation of GG. In this study, we analysed translesion synthesis (TLS) across two contiguous Oz molecules (OzOz) using Klenow Fragment exo(-) (KF exo(-)) and DNA polymerases (Pols) α, β, ζ, η, ι, κ and REV1. We found that KF exo(-) and Pols α, β, ι and REV1 inserted one nucleotide opposite the 3' Oz of OzOz and stalled at the subsequent extension, and that Pol κ incorporated no nucleotide. Pol η only inefficiently elongated the primer up to full-length across OzOz; the synthesis of most DNA strands stalled at the 3' or 5' Oz of OzOz. Surprisingly, however, Pol ζ efficiently extended the primer up to full-length across OzOz, unlike the other DNA polymerases, but catalysed error-prone nucleotide incorporation. We therefore believe that Pol ζ is required for efficient TLS of OzOz. These results show that OzOz obstructs DNA synthesis by DNA polymerases except Pol ζ.

  3. INDEPENDENT VERIFICATION SURVEY REPORT FOR EXPOSURE UNITS Z2-24, Z2-31, Z2-32, AND Z2-36 IN ZONE 2 OF THE EAST TENNESSEE TECHNOLOGY PARK OAK RIDGE, TENNESSEE

    None

    2013-10-10

    The U.S. Department of Energy (DOE) Oak Ridge Office of Environmental Management selected Oak Ridge Associated Universities (ORAU), through the Oak Ridge Institute for Science and Education (ORISE) contract, to perform independent verification (IV) at Zone 2 of the East Tennessee Technology Park (ETTP) in Oak Ridge, Tennessee. ORAU has concluded IV surveys, per the project-specific plan (PSP) (ORAU 2013a) covering exposure units (EUs) Z2-24, -31, -32, and -36. The objective of this effort was to verify the following. • Target EUs comply with requirements in the Zone 2 Record of Decision (ROD) (DOE 2005), as implemented by using the dynamic verification strategy presented in the dynamic work plan (DWP) (BJC 2007) • Commitments in the DWP were adequately implemented, as verified via IV surveys and soil sampling The Zone 2 ROD establishes maximum remediation level (RLmax) values and average RL (RLavg) values for the primary contaminants of concern (COCs) U-234, U-235, U-238, Cs-137, Np-237, Ra-226, Th-232, arsenic, mercury, and polychlorinated biphenyls (PCBs). Table 1.1 lists Zone 2 COCs with associated RLs. Additional radiological and chemical contaminants were also identified during past characterization and monitoring actions, though the ROD does not present RLs for these potential contaminants. IV activities focused on the identification and quantification of ROD-specific COCs in surface soils, but also generated data for other analytes to support future decisions. ORAU personnel also reviewed EU-specific phased construction completion reports (PCCRs) to focus IV activities and identify potential judgmental sample locations, if any.

  4. Catalytic performance of Fe3O4-CoO/Al2O3 catalyst in ozonation of 2-(2,4-dichlorophenoxy) propionic acid,nitrobenzene and oxalic acid in water

    Shaoping Tong; Rui Shi; Hua Zhang; Chunan Ma

    2010-01-01

    the precursors,and its catalytic performance was investigated in ozonation of 2-(2,4-dichlorophenoxy) propionic acid (2,4-DP),nitrobenzene and oxalic acid.The experimental results indicated that Fe3O4-CoO/Al2O3 catalyst enabled an interesting improvement of ozonation efficiency during the degradation of each organic pollutant,and the Fe3O4-CoO/Al2O3 catalytic ozonation system followed a radical-type mechanism.The kinetics of ozonation alone and Fe3O4-CoO/Al2O3 catalytic ozonation of three organic pollutants in aqueous solution were discussed under the mere consideration of direct ozone reaction and OH radical reaction to well investigate its performance.In the catalytic ozonation of 2,4-DP,the apparent reaction rate constants (k) were determined to be 1.456×10-2 min-1 for ozonation alone and 4.740×10-2 min-1 for O3/Fe3O4-CoO/Al2O3.And O3/Fe3O4-CoO/Al2O3 had a larger Rct (6.614×10-9) calculated by the relative method than O3 did (1.800×10-9),showing O3/Fe3O4-CoO/Al2O3 generated more hydroxyl radical.Similar results were also obtained in the catalytic ozonation of nitrobenzene and oxalic acid.The above results demonstrated that the catalytic performance of Fe3O4-CoO/Al2O3 in ozonation of studied organic substance was universal to a certain degree.

  5. 22 CFR 224.2 - Definitions.

    2010-04-01

    ... limited to any advantage, preference, privilege, license, permit, favorable decision, ruling, status, or..., or accounting or bookkeeping entry made— (a) With respect to a claim or to obtain the approval...

  6. 12 CFR 22.4 - Exemptions.

    2010-01-01

    ... State-owned property covered under a policy of self-insurance satisfactory to the Director of FEMA, who publishes and periodically revises the list of States falling within this exemption; or (b)...

  7. 22 CFR 224.21 - Discovery.

    2010-04-01

    ....21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of... document or the truth of any relevant fact; (3) Written interrogatories; and (4) Depositions. (b) For...

  8. CopperCore 2.2.4

    Vogten, Hubert; Martens, Harrie; Koper, Rob

    2005-01-01

    Changed in this release: -fixed bug with the id of the Monitor object and other services, fixed bugs with regard to the visibility of items. Please go to SourceForge for the original sources and website (this is only a backup archive): http://coppercore.sourceforge.net/ Available under the GNU GPL l

  9. 40 CFR 52.224 - General requirements.

    2010-07-01

    ... County APCD. (xvi) Shasta County APCD. (xvii) Sacramento County APCD. (xviii)-(xix) (xx) Lake County APCD...) (xxvi) San Luis Obispo County APCD. (xxvii) Kings County APCD. (xxviii) Plumas County APCD....

  10. 31 CFR 800.224 - Transaction.

    2010-07-01

    ... SECURITY, DEPARTMENT OF THE TREASURY REGULATIONS PERTAINING TO MERGERS, ACQUISITIONS, AND TAKEOVERS BY... merger, acquisition, or takeover. It includes: (a) The acquisition of an ownership interest in an entity. (b) The acquisition or conversion of convertible voting instruments of an entity. (c) The...

  11. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    Aleissa, Khalid A.; Almasoud, Fahad I.; Islam, Mohammed S. [Atomic Energy Research Institute, King Abdul Aziz City for Science and Technology, P.O. Box 6086, Riyadh 11442 (Saudi Arabia); L' Annunziata, Michael F. [IAEA Expert, Montague Group, P.O. Box 5033, Oceanside, CA 92052-5033 (United States)], E-mail: mlannunziata@cox.net

    2008-12-15

    The activities of {sup 228}Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide {sup 228}Ac. The radium was pre-concentrated on MnO{sub 2} and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter {sup 228}Ra({sup 228}Ac), the daughter nuclide {sup 228}Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by {sup 228}Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9{+-}0.1% was measured for {sup 228}Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317{+-}0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of {sup 228}Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for {sup 228}Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure {sup 228}Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  12. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228.

    Aleissa, Khalid A; Almasoud, Fahad I; Islam, Mohammed S; L'Annunziata, Michael F

    2008-12-01

    The activities of (228)Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide (228)Ac. The radium was pre-concentrated on MnO(2) and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter (228)Ra((228)Ac), the daughter nuclide (228)Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by (228)Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9+/-0.1% was measured for (228)Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317+/-0.013cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of (228)Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for (228)Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure (228)Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used.

  13. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  14. The effect of antioxidant concentration of N-isopropyl-N-phenyl-p-phenylenediamine, and 2,2,4-trimethyl-1,2-dihydroquinoline and mixing time of physical properties, thermal properties, mechanical properties and microstructure on natural rubber compound

    Budiarto

    2017-03-01

    Study the influence of high concentrations of antioxidants N-isopropyl-N-phenyl-p-phenylenediamine (IPPD) and 2,2,4-trimethyl-1,2-dihydroquinoline (TMQ) and the mixing time of the vulcanization physical properties, thermal properties, mechanical properties and structure micro on natural rubber compound has been done. The purpose of this study is to compare the effect of anti-oxidants types IPPD and TMQ and mixing time of vulcanization of the physical properties, mechanical properties, microstructure and elemental composition of the synthesis of natural rubber compound. Processes of vulcanization with variations in the concentration of antioxidant IPPD and TMQ: 2, 3, and 4 grams and mixing time: 20, 30, and 40 minutes. Analysis characterization of physical properties and mechanical properties of natural rubber compound showed that the maturity value 0,499Nm (TMQ) and 0.489 Nm (IPPD), Mooney viscosity value of 26.7 (TMQ) and 20.8 (IPPD), the value of the elongation at break 583.75 % (IPPD), and 552.63% (TMQ) as well as the value of tensile strength of 28.108 M.Pa (TMQ), and 27.986 M.Pa (IPPD). Analysis of thermal properties of natural rubber compound antioxidant IPPD with DTA shows there are three endothermic peak on the curve that is temperature 405°C, 550°C and 660°C and tested by TGA showed that the curve of the total reduction in the sample are 81.745% and compound rubber antioxidant TMQ with the analysis of DTA also contained 3 endothermic peak at a temperature 397,21°C, 514,02°C, and 610,27°C and TGA analysis shows the curve of the total sample of 82.356% reduction. Gsi fun group analysis rubber-antioxidant compound IPPD / TMQ with FTIR spectrophotometer shows some typical infrared absorption peak at the wave number (1 / λ) 833-895 cm-1 for cluster / CH bonds, 1,313 cm-1 for group / single bond Si-O, 1368 cm-1 to g ugus / single bond CC, 1507 cm-1, for cluster / bond C = C, 1665 cm-1For cluster / bond-C = O, 2128 cm-1 is the group / bond CN single, 3371

  15. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  16. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of {sup 225}Ac radioimmunotherapy.

  17. Dicty_cDB: AFO224 [Dicty_cDB

    Full Text Available ksck*ey snr*slrftrketllqsw*t*cscp*t*lcrpir*syrkrsfithllwyskw*fcnfthc wcsswyrn*thr*w*nyn*rccwssns*ilftnfrei...ki*ni Frame B: fkknhlgnlkifnikk*kksflttfvyaeekkrnekyiiirfwlcckast*lplkkrrlf cnnc*fi

  18. Dicty_cDB: VHB224 [Dicty_cDB

    Full Text Available F082188.1 Candida albicans glucoamylase (GCA1) gene, complete cds. 40 7.2 2 DY301183 |DY301183.1 KN0AAQ12YG10RM1 CitNFL Citrus clemen...tina cDNA 5', mRNA sequence. 40 9.8 2 dna update 2007. 3

  19. 1935 15' Quad #224 Aerial Photo Mosaic Index

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  20. 49 CFR 224.106 - Location of retroreflective sheeting.

    2010-10-01

    ... ladders and other safety appliances, pipes, or other attachments that may obscure its visibility... each car side. (b) Locomotives. Locomotives subject to this part shall be equipped with at least the... or 36 inches long and spaced as uniformly as practicable along the length of the locomotive sides,...

  1. Dicty_cDB: SHG224 [Dicty_cDB

    Full Text Available EMSGNILLTVPMDFPRGCKSFGGSFCIPGEYSAWSSVYFESQPWISDL TMDGEDMIISIRDRGGDLDRDVGTYDMLRACFDGDQLILENSGICGGVPGAHLLPSGYF...AWSSVYFESQPWISDL TMDGEDMIISIRDRGGDLDRDVGTYDMLRACFDGDQLILENSGICGGVPGAHLLPSGYFG TPDGINSGEYYNDNFYYPTDNDGHDNVAST

  2. Dicty_cDB: VSI224 [Dicty_cDB

    Full Text Available yk mek*e*iy*w*ntsc*ifkkemgkrg*i*tn*rvvdissw***ncrqici*merfkw*lv *iiwk*klgiq*iwsngsktcink*sln**itkiislamr*kt*...*iy*w*ntsc*ifkkemgkrg*i*tn*rvvdissw***ncrqici*me rfkw*lv*iiwk*klgiq*iwsngsktcink*sln**itkiislamr*kt**sskfirf

  3. 29 CFR 779.224 - Common control in other cases.

    2010-07-01

    ... discussed in §§ 779.225 through 779.235. Leased Departments, Franchise and Other Business Arrangements ... business activities with other persons or corporations. In such a case, the activities may be performed... arrangement between the parties so as to vest the control of the activities of one business in the hands...

  4. Combating Opium in Afghanistan. Strategic Forum, Number 224, November 2006

    2006-11-01

    unconvincing, given the Taliban’s previous draconian crackdown on poppy production; however, desperation breeds strange bedfellows. Rampant drug...Depending on their location within Afghanistan, farmers may be able to plant two crops a year; many follow a poppy harvest with a cannabis crop. The

  5. Dicty_cDB: AFH224 [Dicty_cDB

    Full Text Available ficant alignments: (bits) Value N BI315670 |BI315670.1 saf75f12.y1 Gm-c1078 Glycine max cDNA clone GENOME SYSTEMS... CLONEINHIBITOR. ;, mRNA sequence. 56 5e-06 2 AI437629 |AI437629.1 sa37e09.y1 Gm-c1004 Glycine max cDNA clone GENOME SYSTEMS... BE800797 |BE800797.1 sq98c12.y1 Gm-c1049 Glycine max cDNA clone GENOME SYSTEMS C... 1 AW397479 |AW397479.1 sg79d05.y1 Gm-c1007 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1007-2626 5'...04 1 BG790353 |BG790353.1 sae68c10.y1 Gm-c1064 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1064-3212

  6. Medicinal chemistry of 2,2,4-substituted morpholines.

    Rekka, E A; Kourounakis, P N

    2010-01-01

    We have designed a number of 2-hydroxy (alkoxy)-2-aryl-4-alkyl-(5,6-alkyl)-morpholines with interesting biological activities, i.e. sympathomimetic, analgesic, drug metabolizing enzyme modulating ability, antioxidant potential, anti-inflammatory and anti-dyslipidemic properties. They are synthesised by reaction of the proper 2-aminoethanol with aryl-bromomethyl-ketone. The intermediate hydroxyaminoketone is spontaneously cyclised to form the tetrahydro-1,4-oxazine ring. The produced 2-hydroxy substituted morpholines form the 2-alkoxy derivatives. The 2-hydroxy or 2-alkoxy-1,4-oxazine derivatives can lose water or alcohol, to give styrene-type products. The conditions for oxazine ring formation and water or alcohol abstraction are investigated. Ionisation constants and partition coefficients have been determined and related to structure and activity. The biological activities of these compounds are quite interesting: The 2-phenyl analogues acquire the structural requirements for sympathomimetic amines, and present a structure related to the pethidine-type analgesics. Indeed, they show central dopaminergic and analgesic, antagonized by naloxone, activities. They also affect drug metabolising enzymes. The 2- phenyl and especially the 2-biphenyl derivatives are good antioxidants, also possessing anti-inflammatory and immunomodulating action. The later class of compounds reduces remarkably plasma triglycerides, total cholesterol and LDL-cholesterol in hyperlipidemic rats. Since NO plays a multiple role in atheromatosis and inflammation, some 2-nitroxy-alkoxy derivatives are synthesized and their NO-liberating ability assessed. These nitric esters are also found to be potent hypolipidemic-hypocholesterolemic agents. In a mechanism elucidation attempt, it is indicated that these derivatives may act as squalene synthase inhibitors.

  7. 4 CFR 22.4 - Appeal File [Rule 4].

    2010-01-01

    .... Numbering of pages shall be consecutive and continuous from one page to the next (i.e., “Bates” numbered... numbered pages. Preceding each Bates number shall be a designation “A” for appellant or “R” for respondent... alternative organization of the appeal file is permitted, such as by document type or topic, documents...

  8. 7 CFR 2.24 - Assistant Secretary for Administration.

    2010-01-01

    ... management, waste prevention and resource recycling, and logistics. Maintain liaison with the Office of the... program (7 U.S.C. 8102). (K) Entering into cooperative agreements to further research programs in the food... funds under the Act of August 30, 1890 (7 U.S.C. 321, et seq.) including Tuskegee University; and...

  9. Dicty_cDB: CHE224 [Dicty_cDB

    Full Text Available SDVKFLNTPHFELPPNANPGDFLR ETFDHPSAPKALEFAHGTTTLAFVYGGGIIVSXDSKSTQGPY--- ---rthlccccx*nfskxxifi*rxrfingxydywlg...*nwtxiilc***wd*itwstffm wxrfnxxlwcfxxrf*mgye*xxsi*trsxsclscnsqxxllwwxyqclscskrwle...fkyttfrittkcksr*ffkr ni*ssistksigictwynyisiciwwryycixrfkiytrtir--- ---nssllllhxkf*qxlxihikxtvyqwxl*llvgikldx...nyimlimmgldymvnvfhv xqvqxmxmvfxxqvlngi*mxxkhmnsvxxlfimqltxxltlvxlsmfimfkkmvgxrfl lmixsnxixnitilxqlinqxn*xqxl

  10. 2-[(2,4-Dimethylphenyliminomethyl]-3,5-dimethoxyphenol

    Hasan Tanak

    2009-07-01

    Full Text Available X-ray analysis reveals that the title Schiff base compound, C17H19NO3, possesses both OH and NH tautomeric character in its molecular structure. The occupancies of the enol and keto tautomers are 0.62 (3 and 0.38 (3, respectively. The presence of the minor keto form could not be confirmed from the IR spectrum. The molecule is approximately planar, the dihedral angle between the planes of the two aromatic rings being 6.97 (8°. The molecular structure of the major component is stabilized by an intramolecular O—H...N hydrogen bond, which generates an S(6 ring motif (N—H...O hydrogen bond in the minor component.

  11. N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I.

    Thorneloe, Kevin S; Sulpizio, Anthony C; Lin, Zuojun; Figueroa, David J; Clouse, Angela K; McCafferty, Gerald P; Chendrimada, Tim P; Lashinger, Erin S R; Gordon, Earl; Evans, Louise; Misajet, Blake A; Demarini, Douglas J; Nation, Josephine H; Casillas, Linda N; Marquis, Robert W; Votta, Bartholomew J; Sheardown, Steven A; Xu, Xiaoping; Brooks, David P; Laping, Nicholas J; Westfall, Timothy D

    2008-08-01

    The transient receptor potential (TRP) vanilloid 4 (TRPV4) member of the TRP superfamily has recently been implicated in numerous physiological processes. In this study, we describe a small molecule TRPV4 channel activator, (N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), which we have used as a valuable tool in investigating the role of TRPV4 in the urinary bladder. GSK1016790A elicited Ca2+ influx in mouse and human TRPV4-expressing human embryonic kidney (HEK) cells (EC50 values of 18 and 2.1 nM, respectively), and it evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. In contrast, the TRPV4 activator 4alpha-phorbol 12,13-didecanoate (4alpha-PDD) was 300-fold less potent than GSK1016790A in activating TRPV4 currents. TRPV4 mRNA was detected in urinary bladder smooth muscle (UBSM) and urothelium of TRPV4+/+ mouse bladders. Western blotting and immunohistochemistry demonstrated protein expression in both the UBSM and urothelium that was absent in TRPV4-/- bladders. TRPV4 activation with GSK1016790A contracted TRPV4+/+ mouse bladders in vitro, both in the presence and absence of the urothelium, an effect that was undetected in TRPV4-/- bladders. Consistent with the effects on TRPV4 HEK whole-cell currents, 4alpha-PDD demonstrated a weak ability to contract bladder strips compared with GSK1016790A. In vivo, urodynamics in TRPV4+/+ and TRPV4-/- mice revealed an enhanced bladder capacity in the TRPV4-/- mice. Infusion of GSK1016790A into the bladders of TRPV4+/+ mice induced bladder overactivity with no effect in TRPV4-/- mice. Overall TRPV4 plays an important role in urinary bladder function that includes an ability to contract the bladder as a result of the expression of TRPV4 in the UBSM.

  12. Temporal Variations in Surface Concentrations of Terrestrial Lead 210 and Uranium 235 Radionucleides

    Yoshimori, M.

    We have started to measure the surface concentrations of terrestrial radionucleides of lead 210 and uranium 235 in Tokyo (N35, E139) in 2002. Lead 210 which is a daughter nucleus of Rn-222 (uranium series) emits 46 keV gamma-ray with a half-life of 22.4 years, while uranium 235 (actinium series) emits a gamma-ray at 186 keV with a half-life of 0.7 billion years. The present measurement of the surface concentration of lead 210 exhibits two peaks in spring and fall, similar to the beryllium 7 seasonal variations, while the uranium 235 concentration does not vary with time within statistical errors. These two terrestrial radionucleides exhibit different temporal variations on the surface. We discuss possible explanations for the differences in the temporal variations from a point of view of differences in their altitude distribution.

  13. V2O5-TiO2-AlF3/Al2O3催化臭氧化2,4-滴丙酸的氧化效能%Oxidative efficiency of ozonation of 2-(2,4-dichlorophenoxy)propionic acid in the presence of V2O5-TiO2-AlF3/Al2O3

    蓝小飞; 曹利刚; 恽正兴; 童少平

    2013-01-01

    A novel tri-components catalyst characterized as V2O5-TiO2-AlF3/Al2O3 by XRD was prepared via incipient wetness impregnation to promote ozonation efficiency.The activity of the catalyst in ozonation was evaluated by degradation of 2-(2,4-dichlorophenoxy) propionic acid (2,4-DP).The results showed that the catalyst could greatly improve the efficiency of ozonation of 2,4-DP.The test of tert-butyl alcohol addition indicated that the catalytic ozonation of 2,4-DP might follow a hydroxyl radical-type mechanism.The Rct value of the catalytic ozonation calculated by the relative method was larger than that of ozonation alone.The repeated test indicated that the catalyst remained relatively stable in the catalytic ozonation of 2,4-DP.The above results are of great significance for extending application of catalytic ozonation of advanced oxidation process in wastewater treatment.%为了提高有机物的臭氧化降解效率,工作中利用浸渍法制备了一种新型的三组分催化剂(记为V2O5-TiO2-AlF3/Al2O3).催化臭氧化降解2,4-滴丙酸的实验结果表明,该催化剂能有效提高臭氧化的效率,体系可能遵循羟基自由基的作用机理.利用相对法计算结果表明,与单独臭氧化相比,V2O5-TiO2-AlF3/Al2O3催化臭氧化体系具有更大的Rct值.重复实验结果表明,该催化剂具有相对较好的稳定性.以上研究结果对推广催化臭氧化技术在实际废水处理中的应用具有重要的实际意义.

  14. Radiochemical determination and separation or total radium, 226Ra and 224Ra; Analisis Radioquimico de Radio total, Radio-226 y Radio-224

    Suarez, J. A.; Gonzalez, J. A.; Pablo, M. A. de

    1987-07-01

    Radiochemical purification and separation of radium has been carried out and the determination of total radium solubilized in aqueous samples has been studied assuming that all the alpha emitters of the sample have their origin in the 226Ra and elements of its desintegration chain. Also, the activities of 22Ra and 226 Ra have been evaluated separately doing a measurement after the chemical separation of the radium and another one 10 days after. (Author) 9 refs.

  15. 两种稀土产品中放射性核素分析研究%ANALYSIS OF RADIONUCLIDES IN TWO RARE EARTH PRODUCTS

    周程; 孙恋君

    2009-01-01

    利用高纯锗γ谱仪对两个稀土产品氯化镧和氯化钇的样品进行能谱分析,研究经湿法冶炼工艺后的稀土产品中放射性核素的活度变化.结果表明,样品中存在天然放射性钍系和锕-铀系的核素,以及天然放射性核素~(138)La和~(176)Lu,但两个样品中所含的放射性核素不相同.氯化镧产品中锕-铀系和钍系核素放射性未达平衡,其主要子体~(224)Ra和~(227)Th的含量随时间发生明显变化,约60天达到平衡;而氯化钇产品没有这种现象.%This paper describes a study on raidoactivity change of rare-earth products after hydrometallurgy technology,using HPGe gamma spectrometer to analyze two rare earth products (LaCl_3 and YCl_3).The results show that in the two samples exist natural radionuclides of thorium series and actinium-uranium series as well as other natural radionuclides 138 La and 176 Lu.In the sample of lanthanum chloride the radioactivity of actinium-uranium series and thorium series has not reached balance,the contents of their main progenies ~(226)Ra and ~(227)Th obviously changes with the time,reaching balance 60 days later,while YCl_3 keeps stability.

  16. Topographic Map of Quadrangle 3670, Jam-Kashem (223) and Zebak (224) Quadrangles, Afghanistan

    Bohannon, Robert G.

    2006-01-01

    This map was produced from several larger digital datasets. Topography was derived from Shuttle Radar Topography Mission (SRTM) 85-meter digital data. Gaps in the original dataset were filled with data digitized from contours on 1:200,000-scale Soviet General Staff Sheets (1978-1997). Contours were generated by cubic convolution averaged over four pixels using TNTmips surface-modeling capabilities. Minor artifacts resulting from the auto-contouring technique are present. Streams were auto-generated from the SRTM data in TNTmips as flow paths. Flow paths were limited in number by their Horton value on a quadrangle-by-quadrangle basis. Peak elevations were averaged over an area measuring 85 m by 85 m (represented by one pixel), and they are slightly lower than the highest corresponding point on the ground. Cultural data were extracted from files downloaded from the Afghanistan Information Management Service (AIMS) Web site (http://www.aims.org.af). The AIMS files were originally derived from maps produced by the Afghanistan Geodesy and Cartography Head Office (AGCHO). Because cultural features were not derived from the SRTM base, they do not match it precisely. Province boundaries are not exactly located. This map is part of a series that includes a geologic map, a topographic map, a Landsat natural-color-image map, and a Landsat false-color-image map for the USGS/AGS (Afghan Geological Survey) quadrangles covering Afghanistan. The maps for any given quadrangle have the same open-file number but a different letter suffix, namely, -A, -B, -C, and -D for the geologic, topographic, Landsat natural-color, and Landsat false-color maps, respectively. The open-file report (OFR) numbers for each quadrangle range in sequence from 1092 - 1123. The present map series is to be followed by a second series, in which the geology is reinterpreted on the basis of analysis of remote-sensing data, limited fieldwork, and library research. The second series is to be produced by the USGS in cooperation with the AGS and AGCHO.

  17. CTEPP STANDARD OPERATING PROCEDURE FOR HANDLING MISSING SAMPLES AND DATA (SOP-2.24)

    This SOP describes the method for handling missing samples or data. Missing samples or data will be identified as soon as possible during field sampling. It provides guidance to collect the missing sample or data and document the reason for the missing sample or data.

  18. 2-[2-(4-Nitrophenylhydrazinylidene]-1,3-diphenylpropane-1,3-dione

    Carlos Bustos

    2011-07-01

    Full Text Available In the molecular structure of the title compound, C21H15N3O4, the interplanar angle between the benzoyl units is 89.7 (1°. The corresponding angles between the phenylhydrazono and the benzoyl groups are 31.4 (3 and 60.8 (2°, respectively. In the crystal, a strong resonance-assisted intramolecular hydrogen bond (N—H...O and a weak intramolecular hydrogen bond (C—H...N strongly affect the observed conformation of the molecule. The crystal packing is determined by a strong intermolecular hydrogen bond (N—H...O, giving rise to a helical chain along the a axis. In addition, two weak intermolecular contacts (C—H...O are observed.

  19. 50 CFR 224.101 - Enumeration of endangered marine and anadromous species.

    2010-10-01

    ... Gorge in the town of Indian Stream Township on the Kennebec River; Big Niagara Falls on Nesowadnehunk... marine environment. The following impassable falls delimit the upstream extent of the freshwater range: Rumford Falls in the town of Rumford on the Androscoggin River; Snow Falls in the town of West Paris...

  20. Aleksandr Gol’ts, Armiia Rossii: 11 poteriannykh let, Moscow: Zakharov, 2004, 224 pp.

    Richard F. Staar

    2004-07-01

    Full Text Available Specialist of military questions, Aleksandr Gol’ts worked for Red Star (Krasnaia Zvezda, the newspaper of the Russian Ministry of Defense, before joining various prestigious magazines such as Itogi. He is considered one of the most prominent journalist on military matters in Russia today. His book, “The Russian Army : 11 lost years”, is dedicated to military reforms in post-Soviet Russia. With his extensive knowledge of institutional realities of the military establishment, Gol’ts provides a...

  1. (2E-2-[2-(4-Chlorophenylhydrazin-1-ylidene]-4,4,4-trifluoro-3-oxobutanal

    Yan-Ping Huo

    2010-07-01

    Full Text Available The title compound, C10H6ClF3N2O2, was synthesized by coupling 4-dimethylamino-1,1,1-trifluorobut-3-en-2-one with 4-chlorobenzenediazonium chloride. It crystallizes with two molecules in the asymmetric unit, which form two similar centrosymmetric dimers via hydrogen bonds. Extensive electron delocalization and intramolecular N—H...O hydrogen bonds are responsible for a planar conformation of the molecules (maximum deviations = 0.010 and −0.015 Å for the two molecules. In addition to hydrogen bonds, π–π stacking interactions with centroid–centroid distances of 3.604 (2 and 3.583 (2 Å contribute to the stability of the crystal structure.

  2. 25 CFR 224.63 - What provisions must a TERA contain?

    2010-04-01

    ... and G of this part. (c) A provision under which the tribe establishes and ensures compliance with an... compliance with terms and conditions; (6) Assurances of the tribe's compliance with all applicable...) provide a framework the tribe may use to ensure that its records under a TERA adequately...

  3. 22 CFR 224.40 - Stays ordered by the Department of Justice.

    2010-04-01

    ... related to such claim or statement, the A.I.D. Administrator shall stay the process immediately. The A.I.D. Administrator may order the process resumed only upon receipt of the written authorization of the Attorney.... Administrator a written finding that continuation of the administrative process described in this part...

  4. 2-[2-(4-Acetylphenylhydrazinylidene]-1,3-diphenylpropane-1,3-dione

    Carlos Bustos

    2011-08-01

    Full Text Available In the title compound, C23H18N2O3, the interplanar angle between the benzoyl units is 80.51 (6° while the dihedral angles between the hydrazinylidene and benzoyl groups are 43.43 (6 and 54.16 (6°. In the crystal, a strong resonance-assisted intramolecular N—H...O hydrogen bond is observed. The molecules form an inversion dimer via a pair of weak C—H...O hydrogen bonds and a π–π interaction [centroid–centroid distance of 3.5719 (10 Å]. These dimers are linked via weak C—H...O contacts, forming chains along the b axis.

  5. Deliverable 2.24. Changes in ecological status at RIvPACS reference condition sites

    Vincent, Helen; Edwards, Francois; Baker, Roger; Dunbar, Mike; Clarke, Ralph

    2014-01-01

    The WFD requires Member States to determine the ecological status of rivers and streams with respect to deviation from a type-specific reference condition. It is essential that Member States can demonstrate that the biological datasets used to define reference conditions meet the criteria of the WFD. The approach requires that reference sites be at their ecological optima, and are assumed to not change because by definition they are not impacted. We used RIvPACS reference site data and UK Env...

  6. Validation of MIPAS IMK/IAA V5R_O3_224 ozone profiles

    A. Laeng

    2014-11-01

    Full Text Available We present the results of an extensive validation program of the most recent version of ozone vertical profiles retrieved with the IMK/IAA (Institute for Meteorology and Climate Research/Instituto de Astrofísica de Andalucía MIPAS (Michelson Interferometer for Passive Atmospheric Sounding research level 2 processor from version 5 spectral level 1 data. The time period covered corresponds to the reduced spectral resolution period of the MIPAS instrument, i.e., January 2005–April 2012. The comparison with satellite instruments includes all post-2005 satellite limb and occultation sensors that have measured the vertical profiles of tropospheric and stratospheric ozone: ACE-FTS, GOMOS, HALOE, HIRDLS, MLS, OSIRIS, POAM, SAGE II, SCIAMACHY, SMILES, and SMR. In addition, balloon-borne MkIV solar occultation measurements and ground-based Umkehr measurements have been included, as well as two nadir sensors: IASI and SBUV. For each reference data set, bias determination and precision assessment are performed. Better agreement with reference instruments than for the previous data version, V5R_O3_220 (Laeng et al., 2014, is found: the known high bias around the ozone vmr (volume mixing ratio peak is significantly reduced and the vertical resolution at 35 km has been improved. The agreement with limb and solar occultation reference instruments that have a known small bias vs. ozonesondes is within 7% in the lower and middle stratosphere and 5% in the upper troposphere. Around the ozone vmr peak, the agreement with most of the satellite reference instruments is within 5%; this bias is as low as 3% for ACE-FTS, MLS, OSIRIS, POAM and SBUV.

  7. 2-[2-(4-Bromophenylhydrazinylidene]-1,3-diphenylpropane-1,3-dione

    Carlos Bustos

    2011-06-01

    Full Text Available The conformation of the title molecule, C21H15BrN2O2, is stabilized by a weak intramolecular C—H...N hydrogen bond and a strong resonance-assisted N—H...O intramolecular hydrogen bond. In the crystal, the molecules are linked by weak intermolecular C—H...O interactions, forming zigzag chains along the b axis.

  8. 25 CFR 224.185 - When are decisions under this part effective?

    2010-04-01

    ... effective as follows: (a) Decisions of the Secretary disapproving a final proposed TERA or a revised final proposed TERA under subpart C of this part, a finding of imminent jeopardy to a physical trust asset under... TERA after the decision was issued; and (3) The Interior Board of Indian Appeals (Board), the...

  9. 25 CFR 224.110 - What must a petition to the Secretary contain?

    2010-04-01

    ... permitted the petitioner to allege tribal noncompliance with a TERA; (d) A description of facts supporting the petitioner's allegation of the tribe's noncompliance with a TERA; (e) A description of the adverse... noncompliance with the TERA; (f) A copy of any written decision the tribe issued responding to the...

  10. 25 CFR 224.151 - When may the Secretary reassume activities?

    2010-04-01

    ... jeopardy to a physical trust asset, the Secretary may reassume activities under a TERA in accordance with this subpart. The Secretary may also reassume activities approved under a TERA in response to a... Secretary—Indian Affairs may reassume activities under a TERA....

  11. 25 CFR 224.58 - What is an application consultation meeting?

    2010-04-01

    ... that the tribe may designate to discuss the TERA application. The Secretary will designate... responsibility and available resources that the Department would provide to the tribe upon the approval of a TERA... of a TERA or by leases, business agreements, or rights-of-way that the tribe may enter into or...

  12. 25 CFR 224.132 - How does the Director conduct a periodic review and evaluation?

    2010-04-01

    ...) The Director will conduct a periodic review and evaluation under the TERA, in consultation with the... the tribe prepares under the TERA; (2) Conduct on-site inspections as appropriate; and (3) Review compliance with statutes and regulations applicable to activities undertaken under the TERA. (d) Review...

  13. 25 CFR 224.131 - What is a periodic review and evaluation?

    2010-04-01

    ... of energy resources and to review compliance with a TERA. During the TERA consultation, a tribe and... circumstances and the terms and conditions of the tribe's TERA. The tribe will include the agreed-upon periodic review and evaluation process in its final proposed TERA....

  14. 25 CFR 224.136 - How will the Director's report address a tribe's noncompliance?

    2010-04-01

    ... notice of violation of Federal law or the terms of a TERA. (a) If the Director determines that the tribe has not complied with Federal law or the terms of a TERA, the Director's written report must include...

  15. 22 CFR 224.31 - Determining the amount of penalties and assessments.

    2010-04-01

    ... the misconduct; (4) The amount of money or the value of the property, services, or benefit falsely claimed; (5) The value of the Government's actual loss as a result of the misconduct, including... misconduct upon national defense, public health or safety, or public confidence in the management...

  16. Yeast Interacting Proteins Database: YER059W, YDL224C [Yeast Interacting Proteins Database

    Full Text Available ment for passage through Start and commitment to cell division Rows with this prey as prey (1) Rows with thi... passage through Start and commitment to cell division Rows with this prey as prey Rows with this prey as pr

  17. Practical Pseudo-collisions for Hash Functions ARIRANG-224/384

    Guo, Jian; Matusiewicz, Krystian; Knudsen, Lars Ramkilde;

    2009-01-01

    In this paper we analyse the security of the SHA-3 candidate ARIRANG. We show that bitwise complementation of whole registers turns out to be very useful for constructing high-probability differential characteristics in the function. We use this approach to find near-collisions with Hamming weigh...

  18. 2-(2,4-Dichlorophenoxy-1-(1H-pyrazol-1-ylethanone

    Abdul Qayyum Ather

    2010-10-01

    Full Text Available In the title compound, C11H8Cl2N2O2, the 2,4-dichlorophenoxy and 1H-pyrazole groups are almost planar [r.m.s. deviations of 0.0157 and 0.0008 Å, respectively] and are oriented at a dihedral angle of 64.17 (5° with respect to one another. In the crystal, the molecules are stabilized in the form of dimers due to inversion-related C—H...O hydrogen bonds, with R22(10 ring motifs.

  19. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin.

    Nour, S; El-Sharkawy, A; Burnett, W C; Horwitz, E P

    2004-12-01

    The objective of this work was to establish a new procedure for 228Ra determination of natural waters via preconcentration of radium on MnO2 and separation of its daughter, 228Ac, using Diphonix ion exchange resin. Following removal of potential interferences via passage through an initial Diphonix Resin column, the first daughter of 228Ra, 228Ac, is isolated by chromatographic separation via a second Diphonix column. A holding time of > 30 h for 228Ac ingrowth in between the two column separations ensures secular equilibrium. Barium-133 is used as a yield tracer. Actinium-228 is eluted from the second Diphonix Resin with 5 ml 1M 1-Hydroxyethane-1,1-diphosphonic acid (HEDPA) and quantified by addition of scintillation cocktail and LSC counting. Radium (and 133Ba) from the load and rinse solutions from the 2nd Diphonix column may be prepared for alpha spectrometry (for determination of 223Ra, 224Ra, and 226Ra) by BaSO4 microprecipitation and filtration. Decontamination tests indicate that U, Th, and Ra series nuclides do not interfere with these measurements, although high contents of 90Sr (90Y) require additional treatment for accurate measurement of 228Ra. Addition of stable Sr as a "hold back" carrier during the initial MnO2 preconcentration step was shown to remove most 90Sr interference.

  20. 低温等离子射频消融术治疗下咽及喉部病变224例分析%Observation of coblation techinical in treating hypopharynx and larynx diseases (224 cases report)

    罗伟; 吴麟; 陈振宇; 张佳; 郝虹; 王干; 王佩杰

    2016-01-01

    目的:探讨等离子射频消融术治疗下咽及喉部病变的临床应用价值,提高临床疗效。方法回顾性分析2006年4月至2013年4月我科收治的178例下咽病变及46喉部病变患者应用低温等离子射频消融手术的手术方式、手术疗效及术后并发症,探讨低温等离子技术在下咽及喉部病变中的临床应用价值。结果所有手术一次性切除病变完全,术后拔管顺利,无喉梗阻发生,术后恢复良好。下咽组临床治愈169例(94.9%),显效9例(5.1%),总有效率100%,平均住院时间6.8天,所有病例随访1年以上无复发;喉组临床治愈40例(87%),有效4例(8.7%),复发2例(4.3%),2例复发为喉乳头状瘤患者,二次手术后随访1年无复发。平均住院时间7.2天。总有效率95.6%。结论低温等离子射频消融手术创伤小,手术安全性较高、疗效好,住院时间短,是治疗下咽及喉部病变的良好选择。%Objective To explore the clinical valuee of coblation in the treatment of hypopharynx and larynx disease. Methods 178 cases suffered hypopharynx lesion and 46 suffered larynx disease underwent surgical treatment by coblation from April 2006 to April 2013. The operation method, operation effectiveness and postoperation complication were analyzed retrospectively. Results All patients had the total pathological tissue removed without postoperation laryngeal obstruction. Among hypopharynx disease patients, 169 cases were cured and 9 cases had significant therapeutic effect, with a total effective rate of 100%. The mean hospital stay was 6.8 days. In larynx disease patients, 40 were cured and 9 cases had significant therapeutic effect, with a total effective rate of 96.6%. The mean hospital stay was 7.2 days. 2 cased suffered laryngeal papilloma recurrented had second coblation operation and cured in one-year followup. Conclusion Coblation is a safe , effective and minimally invasive way . This operation technical not only shorten the time in hospital but also reduce the cost. It is a valuable selcetive in the treatment of hypopharynx and larynx precancerous lesions.

  1. FA224梳棉机出条速度对生条结杂短绒的影响%The Infulunce of FA224 Card Delivery Speed to Tangly Short Floss

    何远方

    2010-01-01

    为了了解出条速度对生条结杂短绒的影响,在一定的工艺设备条件下,纺制了不同的出条速度的生条,通过对这些生条的测试可知:出条速度对生条质量影响明显,出条速度提高后,生条棉结、杂质有增加的趋势,生条中短绒数量也有增大的趋势,生条质量恶化.

  2. 224例分化型甲状腺癌放射性碘治疗分析%Experience of 224 patients with differentiated thyroid carcinoma by radioiodine therapy

    郭一玲; 陈佐伟; 张英男; 冯程; 辛镇祓

    2011-01-01

    目的:对在我科8年来治疗的分化型甲状腺癌(DTC)患者进行回顾性分析,了解DTC发病规律,并证明131碘治疗DTC的疗效.方法:2002至2010年确诊为DTC并有颈部淋巴结转移的患者,进行甲状腺近全切除,并进行颈部淋巴结清扫,术后131碘治疗.131碘治疗后,每半年随访一次.随访指标:颈部超声检查;血清TSH、FT4、FT3;血清Tg、TgAb检查;全身放射性碘扫描;胸部CT或MRI.疗效判定:当血清Tg、TgAb阴性,颈部超声未见肿大淋巴结,全身放射性碘扫描未见放射性浓聚时,为DTC治愈.当上述指标为阳性时,则进行再次131碘治疗.用SPSS软件进行统计学处理.结果:DTC患者数逐年明显增加;乳头癌与滤泡癌的比例约为12(207):1(17),女性患者远多于男性,男:女患者患病比例约为1(57):3(167);DTC在20-55岁之间为高发年龄段,峰值在25-35岁之间;131碘治疗对DTC治愈率约达90%,近10%的顽固性DTC患者多次131碘治疗效果欠佳.结论:分化型甲状腺癌患病率有明显增加趋势,25-35岁为高发年龄,女性多于男性,早期诊断及早期治疗是关键.手术切除甲状腺后进行131碘治疗对DTC治愈率达90%.近10%的患者131碘治疗效果欠佳,需寻求更好的治疗方法.%Objective: To study the incidence of differentiated thyroid carcinoma ( DTC ) and the outcome of 131 Iodine therapy for DTC, we summarized retrospectively data of patients with DTC who were managed by 131 Iodine therapy in our department in past 8 years. Methods :Patients with DTC and neck lymph nodes metastasis were diagnosed and near - total thyroidectomy were performed, and neck metastatic lymph nodes were excised. After operation they were treated by radioiodine. Patients were followed up once every half of year after 131 Iodine therapy . To observe the following ired: neck ultrasound test , serum TSH, FT4, FT3 test, serum Tg, TgAb test, radioiodine whole body scan,chest CT or MRI. Assessment of outcome of 131 Iodine therapy: when serum Tg,TgAb test was negative, without detectable metastatic lymph nods in neck ultrasound test, radioiodine whole body scan was negative, it was cure, otherwise 131 Iodine therapy was performed again. Result:DTC rates appear to be rising distinctly year after year, incidence of PDC was higher than that of FTC, the ratio of incidence was 12( 207 ): 1( 17 ) ( PTC :FTC ), incidence of female was higher than male, the ratio was 3 ( 167 ):1( 57 )( female:male ). The incidence of DTC was higher in 20 -55 year. Cured rate of 131 Iodine therapy for DTC was 90%. Conclusion:Thyroid cancer rate appear to be rising distinctly year after year. Incidence of DTC is most high in age of 25 - 35 yeas. Incidence of DTC in female patients is higher than males. Early diagnosis and therapy is most important. Cured rate of DTC is up to 90% , when using 131Iodine therapy after operation consequent TSH suppression therapy. Repeat 131Iodine therapy for near 10% of patients with persistent disease is unsatisfactory.

  3. A second monoclinic polymorph of 2-[2-(4-methoxyphenylhydrazinylidene]-1,3-diphenylpropane-1,3-dione

    Carlos Bustos

    2011-07-01

    Full Text Available The title compound, C22H18N2O3 is the second monoclinic polymorph (P21/c of the compound, the first being reported in space group P21 [Bertolasi et al. (1993. J. Chem. Soc. Perkin Trans. 2, pp. 2223–2228]. In the molecular structure of the title compound, the interplanar angle between the benzoyl units is 80.04 (5°, while the corresponding angles between the phenylhydrazinylidene and benzoyl groups are 36.11 (5 and 55.77 (2°. A strong resonance-assisted intramolecular N—H...O hydrogen bond is found. In the crystal, the entire supramolecular structure is constructed by weak intermolecular C—H...O interactions and an inter-ring π–π interaction [centroid–centroid distance = 3.6088 (8 Å].

  4. 2,2-Diethyl 4-methyl 5-(4-nitrophenyl-4-phenylpyrrolidine-2,2,4-tricarboxylate

    Long He

    2011-10-01

    Full Text Available The title compound, C24H26N2O8, was synthesized by the cycloaddition reaction of methyl 2-phenylacrylate, diethyl 2-aminomalonate and 4-nitrobenzaldehyde. The pyrrolidine ring exhibits an envelope conformation. The two benzene rings are located on opposite sides of the pyrrolidine ring and subtend a dihedral angle of 59.16 (14°. The crystal packing is stabilized by N—H...O and weak C—H...O hydrogen bonding.

  5. SU-E-T-224: Is Monte Carlo Dose Calculation Method Necessary for Cyberknife Brain Treatment Planning?

    Wang, L; Fourkal, E; Hayes, S; Jin, L; Ma, C [Fox Chase Cancer Center, Philadelphia, PA (United States)

    2014-06-01

    Purpose: To study the dosimetric difference resulted in using the pencil beam algorithm instead of Monte Carlo (MC) methods for tumors adjacent to the skull. Methods: We retrospectively calculated the dosimetric differences between RT and MC algorithms for brain tumors treated with CyberKnife located adjacent to the skull for 18 patients (total of 27 tumors). The median tumor sizes was 0.53-cc (range 0.018-cc to 26.2-cc). The absolute mean distance from the tumor to the skull was 2.11 mm (range - 17.0 mm to 9.2 mm). The dosimetric variables examined include the mean, maximum, and minimum doses to the target, the target coverage (TC) and conformality index. The MC calculation used the same MUs as the RT dose calculation without further normalization and 1% statistical uncertainty. The differences were analyzed by tumor size and distance from the skull. Results: The TC was generally reduced with the MC calculation (24 out of 27 cases). The average difference in TC between RT and MC was 3.3% (range 0.0% to 23.5%). When the TC was deemed unacceptable, the plans were re-normalized in order to increase the TC to 99%. This resulted in a 6.9% maximum change in the prescription isodose line. The maximum changes in the mean, maximum, and minimum doses were 5.4 %, 7.7%, and 8.4%, respectively, before re-normalization. When the TC was analyzed with regards to target size, it was found that the worst coverage occurred with the smaller targets (0.018-cc). When the TC was analyzed with regards to the distance to the skull, there was no correlation between proximity to the skull and TC between the RT and MC plans. Conclusions: For smaller targets (< 4.0-cc), MC should be used to re-evaluate the dose coverage after RT is used for the initial dose calculation in order to ensure target coverage.

  6. 75 FR 41337 - Implementation of Section 224 of the Act; A National Broadband Plan for Our Future

    2010-07-15

    .... Comments may be filed using: (1) The Commission's Electronic Comment Filing System (ECFS), (2) the Federal... information collection burden for small business concerns with fewer than 25 employees. OMB Control Number... should adopt similar regulations, or leave the details of the application process in the hands...

  7. American Recovery and Reinvestment Act (ARRA) Federal Energy Management Program Technical Assistance Project 224 Altus Air Force Base Solar Technologies

    Russo, Bryan J.

    2010-09-30

    The principal goal of this project was to evaluate altus Air Force Base for building integrated silicon or thin film module photovoltaic opportunities. This report documents PNNL's efforts and documents study conclusions.

  8. 25 CFR 224.72 - How will the Secretary determine whether a tribe has demonstrated sufficient capacity?

    2010-04-01

    ... seeks to assume; (c) Materials and information submitted with the application for a TERA, the result of... final proposed TERA or the tribe's plans for establishing that expertise; (f) The financial capacity of... scope of the proposed TERA....

  9. 25 CFR 224.119 - What must the Director do when making a decision on a petition?

    2010-04-01

    ... for the decision about the tribe's compliance or noncompliance with the TERA within 30 days following... not in compliance with the TERA, the Director must: (1) Include findings of fact and conclusions of law with the written decision to the tribe; and (2) Take action to ensure compliance with the TERA....

  10. 25 CFR 224.80 - Under what authority will a tribe perform activities for energy resource development?

    2010-04-01

    ... TERA under the authorities provided in the approved TERA. Notwithstanding anything in this part or an approved TERA to the contrary, a tribe will retain all sovereign and other powers it otherwise possesses....

  11. 25 CFR 224.141 - What must the Secretary do if the tribe responds to the Director's order?

    2010-04-01

    ... complied with the TERA and the Federal law cited in the notice; and (3) If the Secretary determines, after reviewing the tribe's response, that the tribe has not complied with the TERA or with a Federal law, the... comply with the TERA or Federal law and to protect the physical trust asset; or (2) Take any action...

  12. 25 CFR 224.51 - What is a pre-application consultation between a tribe and the Director?

    2010-04-01

    ... Director? (a) A tribe interested in entering into a TERA should request a pre-application consultation by...) The required content of an application for a TERA; (4) The energy resource the tribe anticipates... energy resource the tribe anticipates developing under a TERA; and (7) Any other matters applicable...

  13. 25 CFR 224.109 - What must a petitioner claim or request in a petition filed with the Secretary?

    2010-04-01

    ... provisions of a TERA, and, as a result, the petitioner's interest has sustained or will sustain an adverse... that the Secretary take whatever action is necessary to bring a tribe into compliance with the TERA....

  14. 25 CFR 224.73 - How will the scope of energy resource development affect the Secretary's determination of the...

    2010-04-01

    ... energy resource development under the TERA will include a determination as to each type of energy resource development subject to the TERA for which the tribe seeks to regulate, and each type of regulatory activity the tribe proposes to assume. The Secretary's review of a TERA must be limited to...

  15. 33 CFR 110.224 - San Francisco Bay, San Pablo Bay, Carquinez Strait, Suisun Bay, Sacramento River, San Joaquin...

    2010-07-01

    ....; thence southeasterly to latitude 37°49′32.5″ N., longitude 122°21′20.5″ W.; thence easterly to latitude...″ W; thence easterly to 37°46′36.5″ N, 122°19′52″ W; thence northerly to shore at 37°46′53″ N, 122°19... 122°21′57″ W; thence easterly along the northern border of Anchorage 9 to latitude 37°46′26″ N...

  16. Radon fixation for determination of {sup 224}Ra, {sup 226}Ra and {sup 228}Ra via gamma-ray spectrometry

    Herranz, M. [Departamento Ingenieria Nuclear y Mecanica de Fluidos, E. S. Ingenieros de Bilbao - Universidad del Pais Vasco (UPV/EHU), Alda. Urquijo s/n, 48013 Bilbao (Spain)]. E-mail: inphesom@bi.ehu.es; Idoeta, R. [Departamento Ingenieria Nuclear y Mecanica de Fluidos, E. S. Ingenieros de Bilbao - Universidad del Pais Vasco (UPV/EHU), Alda. Urquijo s/n, 48013 Bilbao (Spain); Abelairas, A. [Departamento Ingenieria Nuclear y Mecanica de Fluidos, E. S. Ingenieros de Bilbao - Universidad del Pais Vasco (UPV/EHU), Alda. Urquijo s/n, 48013 Bilbao (Spain); Legarda, F. [Departamento Ingenieria Nuclear y Mecanica de Fluidos, E. S. Ingenieros de Bilbao - Universidad del Pais Vasco (UPV/EHU), Alda. Urquijo s/n, 48013 Bilbao (Spain)

    2006-04-15

    The aim of this work is the improvement of the procedure for the determination of radium isotopes activities in water, which is done through radiochemical separation and subsequent gamma-ray spectrometry. In addition, radon gas retention is studied using different activated carbon materials. The results of the IAEA Proficiency test: 'Determination of radium and uranium radionuclides in water' of December 2002 [IAEA, 2003. Analytical quality control services: determination of radium and uranium radionuclides in water. Preliminary Report, Seibersdorf] are considered for this work.

  17. Rob Hopkins, 2008, The Transition Handbook. From Oil Dependency to Local Resilience, Green books, 224 p.

    Luc Semal

    2008-07-01

    Full Text Available Le mouvement pour la Transition (ou Transition movement a été initié en 2005 à Totnes (Devon par Rob Hopkins, professeur de permaculture qui avait été sensibilisé au thème du pic du pétrole quelques mois auparavant : à l’époque, il s’agissait seulement d’élaborer une stratégie locale pour que Totnes puisse à l’avenir se passer de pétrole sans en souffrir. Mais d’autres groupes locaux ont rapidement suivi cet exemple, et en mai 2008, le « réseau de la Transition » comptait déjà 50 localités ...

  18. A family of new glutarate compounds: synthesis, crystal structures of: Co(H2O)5L(1), Na2[CoL2] (2), Na2[L(H2L)4/2] (3), {[Co3(H2O)6L2](HL)2}.4H2O (4), {[Co3(H2O)6L2](HL)2}.10H2O (5), {[Co3(H2O)6L2]L2/2}.4H2O (6), and Na2{[Co3(H2O)2]L8/2].6H2O (7), and magnetic properties of 1 and 2 with H2L = HOOC-(CH2)3-COOH.

    Zheng, Yue-Qing; Lin, Jian-Li; Xu, Wei; Xie, Hong-Zhen; Sun, Jie; Wang, Xian-Wen

    2008-11-17

    Seven new glutaric acid complexes, Co(H 2O) 5L 1, Na 2[CoL 2] 2, Na 2[L(H 2L) 4/2] 3, {[Co 3(H 2O) 6L 2](HL) 2}.4H 2O 4, {[Co 3(H 2O) 6L 2](HL) 2}.10H 2O 5, {[Co 3(H 2O) 6L 2]L 2/2}.4H 2O 6, and Na 2{[Co 3(H 2O) 2]L 8/2].6H 2O 7 were obtained and characterized by single-crystal X-ray diffraction methods along with elemental analyses, IR spectroscopic and magnetic measurements (for 1 and 2). The [Co(H 2O) 5L] complex molecules in 1 are assembled into a three-dimensional supramolecular architecture based on intermolecular hydrogen bonds. Compound 2 consists of the Na (+) cations and the necklace-like glutarato doubly bridged [ C o L 4 / 2 ] 2 - infinity 1 anionic chains, and 3 is composed of the Na (+) cations and the anionic hydrogen bonded ladder-like [ L ( H 2 L ) 4 / 2 ] 2 - infinity 1 anionic chains. The trinuclear {[Co 3(H 2O) 6L 2](HL) 2} complex molecules with edge-shared linear trioctahedral [Co 3(H 2O) 6L 2] (2+) cluster cores in 4 and 5 are hydrogen bonded into two-dimensional (2D) networks. The edge-shared linear trioctahedral [Co 3(H 2O) 6L 2] (2+) cluster cores in 6 are bridged by glutarato ligands to generate one-dimensional (1D) chains, which are then assembled via interchain hydrogen bonds into 2D supramolecular networks. The corner-shared linear [Co 3O 16] trioctahedra in 7 are quaternate bridged by glutarato ligands to form 1D band-like anionic {[Co 3(H 2O) 2]L 8/2} (2+) chains, which are assembled via interchain hydrogen bonds into 2D layers, and between them are sandwiched the Na (+) cations. The magnetic behaviors of 1 and 2 obey the Curie-Weiss law with chi m = C/( T - Theta) with the Curie constant C = 3.012(8) cm (3) x mol (-1) x K and the Weiss constant Theta = -9.4(7) K for 1, as well as C = 2.40(1) cm (3) x mol (-1) x K and Theta = -2.10(5) K for 2, indicating weak antiferromagnetic interactions between the Co(II) ions.

  19. Alpha-emitting isotopes and chromium in a coastal California aquifer

    Densmore, Jill N.; Izbicki, John A.; Murtaugh, Joseph M.; Swarzenski, Peter W.; Bullen, Thomas D.

    2014-01-01

    The unadjusted 72-h gross alpha activities in water from two wells completed in marine and alluvial deposits in a coastal southern California aquifer 40 km north of San Diego were 15 and 25 picoCuries per liter (pCi/L). Although activities were below the Maximum Contaminant Level (MCL) of 15 pCi/L, when adjusted for uranium activity; there is concern that new wells in the area may exceed MCLs, or that future regulations may limit water use from the wells. Coupled well-bore flow and depth-dependent water-quality data collected from the wells in 2011 (with analyses for isotopes within the uranium, actinium, and thorium decay-chains) show gross alpha activity in marine deposits is associated with decay of naturally-occurring 238U and its daughter 234U. Radon activities in marine deposits were as high as 2230 pCi/L. In contrast, gross alpha activities in overlying alluvium within the Piedra de Lumbre watershed, eroded from the nearby San Onofre Hills, were associated with decay of 232Th, including its daughter 224Ra. Radon activities in alluvium from Piedra de Lumbre of 450 pCi/L were lower than in marine deposits. Chromium VI concentrations in marine deposits were less than the California MCL of 10 μg/L (effective July 1, 2014) but δ53Cr compositions were near zero and within reported ranges for anthropogenic chromium. Alluvial deposits from the nearby Las Flores watershed, which drains a larger area having diverse geology, has low alpha activities and chromium as a result of geologic and geochemical conditions and may be more promising for future water-supply development.

  20. Phenotype-gene: 71 [Arabidopsis Phenome Database[Archive

    Full Text Available 71 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1070i decreased efficiency...b.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16467846i decreased efficiency for trait of fertility http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u647i AT4G35520

  1. Phenotype-gene: 517 [Arabidopsis Phenome Database[Archive

    Full Text Available 517 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1514i lethal (sensu genetics...etadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18208520i lethal (sensu genetics) in organ named seedling http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u913i AT1G30520

  2. Phenotype-gene: 31 [Arabidopsis Phenome Database[Archive

    Full Text Available 31 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1030i decreased density of chloroph...iNetS_ria224i/cria224u4ria224u15659096i decreased density of chlorophyll http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u617i AT5G35220

  3. Phenotype-gene: 30 [Arabidopsis Phenome Database[Archive

    Full Text Available 30 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1029i decreased density of chloroph...b.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15525647i decreased density of chlorophyll http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u617i AT3G19040

  4. Phenotype-gene: 29 [Arabidopsis Phenome Database[Archive

    Full Text Available 29 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1028i decreased density of chloroph...db.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18182030i decreased density of chlorophyll http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u617i AT1G78600

  5. Phenotype-gene: 32 [Arabidopsis Phenome Database[Archive

    Full Text Available 32 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1031i decreased density of chloroph...b/SciNetS_ria224i/cria224u4ria224u16262716i decreased density of chlorophyll http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u617i AT5G56860

  6. Phenotype-gene: 554 [Arabidopsis Phenome Database[Archive

    Full Text Available 554 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1551i non-functional obsolete microgametoph...adb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u11251103i non-functional obsolete microgametophyte http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u940i AT5G16830

  7. Phenotype-gene: 552 [Arabidopsis Phenome Database[Archive

    Full Text Available 552 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1549i non-functional obsolete microgametoph...adb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u11251103i non-functional obsolete microgametophyte http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u940i AT4G02195

  8. Phenotype-gene: 553 [Arabidopsis Phenome Database[Archive

    Full Text Available 553 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1550i non-functional obsolete microgametoph...adb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u11251103i non-functional obsolete microgametophyte http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u940i AT4G17730

  9. Phenotype-gene: 582 [Arabidopsis Phenome Database[Archive

    Full Text Available 582 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1579i non-functional unidimensional.../metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16040657i non-functional unidimensional cell growth http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u958i AT1G11680

  10. Phenotype-gene: 583 [Arabidopsis Phenome Database[Archive

    Full Text Available 583 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1580i non-functional unidimensional...etadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u12837954i non-functional unidimensional cell growth http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u958i AT2G20370

  11. SILVA, Saulo Henrique Souza Tolerância civil e religiosa em John Locke São Cristóvão: Editora UFS, 2013. 224p.

    Flavio Fontenelle Loque

    2015-02-01

    Full Text Available Originalmente uma dissertação de mestrado feita sob a orientação de Antônio Carlos dos Santos e defendida em 2008 no programa de pós-graduação da Universidade Federal da Bahia, Tolerância Civil e Religiosa em John Locke (São Cristóvão: Editora UFS, 2013 é um livro relevante e oportuno: relevante porque se constitui num dos poucos publicados no Brasil a tratar especificamente da tolerância em Locke; oportuno porque vem à lume num momento em que é cada vez mais necessário um debate público sobre o convívio entre religiões e a relação entre Estado e Igreja. O livro possui quatro capítulos repletos de subdivisões que organizam muito bem seu desenvolvimento conceitual, sendo os dois primeiros dedicados à tolerância civil e à religiosa, o terceiro aos limites da tolerância e o quarto à noção de moralidade em Locke.

  12. Crystal structure of 2,2,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine hemihydrate

    K. S. Ezhilarasi

    2015-08-01

    Full Text Available The title compound, C12H18N2·0.5H2O, crystallizes with two independent organic molecules (A and B in the asymmetric unit, together with a water molecule of crystallization. The diazepine rings in each molecule have a chair conformation. The dihedral angle between benzene ring and the mean plane of the diazepine ring is 21.15 (12° in molecule A and 17.42 (11° in molecule B. In the crystal, molecules are linked by N—H...O and O—H...N hydrogen bonds, forming zigzag chains propagating along [001].

  13. 2-(2-(4-Benzoylpiperazin-1-ylethylisoindoline-1,3-dione derivatives: Synthesis, docking and acetylcholinesterase inhibitory evaluation as anti-alzheimer agents

    Ahmad Mohammadi-Farani

    2017-01-01

    Full Text Available Objective(s: Alzheimer’s disease (AD as progressive cognitive decline and the most common form of dementia is due to degeneration of the cholinergic neurons in the brain. Therefore, administration of the acetylcholinesterase (AChE inhibitors such as donepezil is the first choice for treatment of the AD. In the present study, we focused on the synthesis and anti-cholinesterase evaluation of new donepezil like analogs. Materials and Methods: A new series of phthalimide derivatives (compounds 4a-4j were synthesized via Gabriel protocol and subsequently amidation reaction was performed using various benzoic acid derivatives. Then, the corresponding anti-acetylcholinesterase activity of the prepared derivatives (4a-4j was assessed by utilization of the Ellman's test and obtained results were compared to donepezil. Besides, docking study was also carried out to explore the likely in silico binding interactions.  Results: According to the obtained results, electron withdrawing groups (Cl, F at position 3 and an electron donating group (methoxy at position 4 of the phenyl ring enhanced the acetylcholinesterase inhibitory activity. Compound 4e (m-Fluoro, IC50 = 7.1 nM and 4i (p-Methoxy, IC50 = 20.3 nM were the most active compounds in this series and exerted superior potency than donepezil (410 nM. Moreover, a similar binding mode was observed in silico for all ligands in superimposition state with donepezil into the active site of acetylcholinesterase. Conclusion: Studied compounds could be potential leads for discovery of novel anti-Alzheimer agents in the future.

  14. (2RS-2-(2,4-Difluorophenyl-1-[(4-iodobenzyl(methylamino]-3-(1H-1,2,4-triazol-1-ylpropan-2-ol

    Hui-Ping Xiong

    2012-08-01

    Full Text Available In the title compound (common name: iodiconazole, C19H19F2IN4O, there is an intramolecular O—H...N hydrogen bond and molecules are linked by weak interactions only, namely C—H...N, C—H...O and C—H...F hydrogen bonds, and π-electron ring–π-electron ring interactions between the triazole rings with centroid–centroid distances of 3.725 (3 Å.

  15. Crystal structure of ethyl 2-[2-(4-methylbenzoyl-5-p-tolyl-1H-imidazol-1-yl]acetate

    E. Arockia Jeya Yasmi Prabha

    2016-03-01

    Full Text Available In the title compound, C22H22N2O3, the plane of the five-membered ring is oriented at dihedral angles of 45.4 (1 and 52.5 (1° to the phenyl rings. Furthermore, this ring makes an angle of 85.2 (2° with the plane of the ethyl acetate substituent. The molecular structure is affected by an intramolecular C—H...O hydrogen bond between an H atom from the p-tolyl group and the carbonyl O atom of the acetate. The methyl group of the ethyl acetate residue is disordered over two sites with equal occupancies. The crystal structure features intermolecular C—H...O and C—H...N interactions. One of the C—H...O hydrogen bonds forms a C(5 chain motif extending along the a axis. In addition, C—H...N contacts form inversion dimers with R22(12 ring motifs, linking the imidazole ring system to the benzene ring of the p-tolyl substituent.

  16. [V16Sb4O42(H2O){VO(C6H14N2)2}4]: a terminal expansion to a polyoxovanadate archetype.

    Wutkowski, Adam; Näther, Christian; Kögerler, Paul; Bensch, Wolfgang

    2008-03-17

    The charge-neutral antimonatopolyoxovanadium(IV) cluster [V(IV)16Sb(III)4O42(H2O){V(IV)O(C6H14N2)2}4].10H2O.C6H14N2 was obtained under solvothermal conditions. The central cluster fragment, [V(IV) 16Sb(III)4O42], is a derivative of the [V18O42] archetype and is formed by replacing two VO5 polyhedra by two Sb2O5 units. The {V20Sb4} structure expands the {V16Sb4} motif by the addition of four square-pyramidal, terminal VO(1,2-diaminocyclohexane)2 groups. At low temperatures, the magnetic ground state is characterized by four independent S = 1/2 sites.

  17. 2-(2,4-Dichlorophenyl-3-[5-(3,5-dimethylphenyl-1,3,4-thiadiazol-2-yl]thiazolidin-4-one

    Rong Wan

    2008-01-01

    Full Text Available The title compound, C19H15Cl2N3OS2, was synthesized by the reaction of N-(2,4-dichlorophenyl-5-(3,5-dimethylphenyl-1,3,4-thiadiazol-2-amine and mercaptoacetic acid. The thiazolidinone ring adopts a twist conformation. The 2,4-dichlorophenyl ring is almost perpendicular to the thiadiazole ring, the dihedral angle being 82.8 (2°. The 3,5-dimethylphenyl ring is nearly coplanar with the thiadiazole ring, the dihedral angle being 2.7 (2°. An intramolecular C—H...N hydrogen bond is present.

  18. 2-(2,4-Dichlorophenyl-3-[5-(4-methoxyphenyl-1,3,4-thiadiazol-2-yl]-1,3-thiazolidin-4-one

    Jin-Tang Wang

    2008-05-01

    Full Text Available In the molecule of the title compound, C18H13Cl2N3O2S2, the thiazolidinone ring has an envelope conformation with the S atom displaced by 0.394 (3 Å from the plane of the other ring atoms. The thiadiazole ring is oriented at a dihedral angle of 7.40 (4° with respect to the 4-methoxyphenyl ring. Intramolecular C—H...S, C—H...N and C—H...Cl hydrogen bonds result in the formation of two planar and two non-planar five-membered rings. The planar five-membered rings are oriented at a dihedral angle of 6.23 (3°. The 2,4-dichlorophenyl ring is oriented at dihedral angles of 84.21 (4 and 83.55 (3° with respect to the thiadiazole and 4-methoxyphenyl rings, respectively. In the crystal structure, intermolecular C—H...O hydrogen bonds link the molecules into centrosymmetric dimers.

  19. Hyperspectral surface materials map of quadrangle 3670, Jurm-Kishim (223) and Zebak (224) quadrangles, Afghanistan, showing iron-bearing minerals and other materials

    King, Trude V.V.; Hoefen, Todd M.; Kokaly, Raymond F.; Livo, Keith E.; Johnson, Michaela R.; Giles, Stuart A.

    2013-01-01

    This map shows the spatial distribution of selected iron-bearing minerals and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. This map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Goethite and jarosite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  20. Hyperspectral surface materials map of quadrangle 3670, Jurm-Kishim (223) and Zebak (224) quadrangles, Afghanistan, showing carbonates, phyllosilicates, sulfates, altered minerals, and other materials

    Kokaly, Raymond F.; King, Trude V.V.; Hoefen, Todd M.; Livo, Keith E.; Johnson, Michaela R.; Giles, Stuart A.

    2013-01-01

    This map shows the spatial distribution of selected carbonates, phyllosilicates, sulfates, altered minerals, and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. The map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Epidote or chlorite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  1. Growth and fermentation of D-xylose by Saccharomyces cerevisiae expressing a novel D-xylose isomerase originating from the bacterium Prevotella ruminicola TC2-24

    Saccharomyces cerevisiae strains expressing xylose isomerase (XI) produce some of the highest reported ethanol yields from xylose. Unfortunately, most bacterial XIs that have been expressed in S. cerevisiae are not functional, require additional strain modification, and have low affinity for xylose...

  2. Comparison of estimated energy intake from 224-hour recalls and a seven-day food record with objective measurements of energy expenditure in children

    Rothausen, Berit Worm; Matthiessen, Jeppe; Groth, Margit Velsing

    2012-01-01

    Objective: The objective of the present study was to evaluate energy intake (EI) estimated from two nonconsecutive 24-hour recalls (24-HDRs) and a pre-coded seven-day food record (7-dFR) against objective measurements of energy expenditure (EE) in children. Design: A total of 67 78 year-olds and 64...

  3. The bispectrum of the Lyman-alpha forest at z~2-2.4 from a Large sample of UVES QSO Absorption Spectra (LUQAS)

    Viel, M; Heavens, A; Hähnelt, M G; Kim, T S; Springel, V; Hernquist, L

    2004-01-01

    We present a determination of the bispectrum of the flux in the Lyman-alpha forest of QSO absorption spectra obtained from LUQAS which consists of spectra observed with the high resolution Echelle spectrograph UVES. Typical errors on the observed bispectrum as obtained from a jack-knife estimator are ~ 50%. For wavenumbers in the range 0.03 s/km 2.

  4. Acetalization of carbonyl compounds with 2,2,4-trimethyl-1,3-pentanedio catalyzed by novel carbon based solid acid catalyst

    Ling Liu; Yuechang Zhao; Shan Gan; Xuezheng Liang; Jianguo Yang; Mingyuan He

    2008-01-01

    The synthesis of 2, 4-diisopropyl-5,5-dimethyl-1,3-dioxane through the acetalization of isobutyraldehyde with 2, 2,4-trimethyl-1,3-pentanediol (TMPD) catalyzed by the novel carbon based acid was first carried out. High conversion (≥98%) and specific selectivity were obtained using the novel carbon based acid, which kept high activity after it was reused 5 times.Moreover, the catalyst could be used to catalyze the acetalization and ketalization of different aldehydes and ketones with superior yield. The yield of several products was over 90%. The novel heterogeneous catalyst has the distinct advantages of high activity, strikingly simple workup procedure, non-pollution, and reusability, which will contribute to the success of the green process greatly.

  5. V.V. Savel’ev, Kak vyzhit’ v neustavnoi armii. (from the series Psychological Practice, Rostov-on-Don, Feniks, 2003, 224 pages.

    Dale Herspring

    2004-07-01

    Full Text Available This is one of the most interesting – and from the perspective of one who is interested in the phenomena of harassment (dedovshchina in the Russian military – one of the most important works this reviewer has encountered in some time. It is clearly written, although it does contain some Russian military phrases and words. It is not intended to be an academic study. Rather, it is written from the vantage point of someone who dealt with such problems for many years.In contrast to many works de...

  6. VizieR Online Data Catalog: Hi-GAL l=224deg region CO(1-0) data cubes (Olmi+, 2016)

    Olmi, L.; Cunningham, M.; Elia, D.; Jones, P.

    2016-08-01

    The files are the Mopra telescope data cubes used to produce the channel maps shown in Appendix A. Intensity units are Ta*[K]. Data cubes are not (baseline) reduced. Noise in the maps is not uniform. Frequency resolution is 33.7kHz. (2 data files).

  7. SU-E-J-224: Using UTE and T1 Weighted Spin Echo Pulse Sequences for MR-Only Treatment Planning; Phantom Study

    Yu, H; Fatemi, A [Sunnybrook Health Sciences Centre, Toronto, Ontario (Canada); Sahgal, A [University of Toronto, Toronto, ON (Canada)

    2015-06-15

    Purpose: Investigating a new approach in MRI based treatment planning using the combination of (Ultrashort Echo Time) UTE and T1 weighted spin echo pulse sequences to delineate air, bone and water (soft tissues) in generating pseudo CT images comparable with CT. Methods: A gel phantom containing chicken bones, ping pang balls filled with distilled water and air bubbles, was made. It scanned with MRI using UTE and 2D T1W SE pulse sequences with (in plane resolution= 0.53mm, slice thickness= 2 mm) and CT with (in plane resolution= 0.5 mm and slice thickness= 0.75mm) as a ground truth for geometrical accuracy. The UTE and T1W SE images were registered with CT using mutual information registration algorithm provided by Philips Pinnacle treatment planning system. The phantom boundaries were detected using Canny edge detection algorithm for CT, and MR images. The bone, air bubbles and water in ping pong balls were segmented from CT images using threshold 300HU, - 950HU and 0HU, respectively. These tissue inserts were automatically segmented from combined UTE and T1W SE images using edge detection and relative intensity histograms of the phantom. The obtained segmentations of air, bone and water inserts were evaluated with those obtained from CT. Results: Bone and air can be clearly differentiated in UTE images comparable to CT. Combining UTE and T1W SE images successfully segmented the air, bone and water. The maximum segmentation differences from combine MRI images (UTE and T1W SE) and CT are within 1.3 mm, 1.1mm for bone, air, respectively. The geometric distortion of UTE sequence is small less than 1 pixel (0.53 mm) of MR image resolution. Conclusion: Our approach indicates that MRI can be used solely for treatment planning and its quality is comparable with CT.

  8. 25 CFR 224.137 - What must the Director do if a tribe's noncompliance has resulted in harm or the potential for...

    2010-04-01

    ... the terms of a TERA, the Director determines that there is harm or the potential for harm to a...-compliance with the TERA or other applicable Federal laws or rescinding approval of all or part of the TERA....

  9. 25 CFR 224.138 - What must the Director do if a tribe's noncompliance has caused imminent jeopardy to a physical...

    2010-04-01

    ... the Director finds that a tribe's noncompliance with a Federal law or the terms of a TERA has caused... TERA; (2) A description of the physical trust asset and the nature of the imminent jeopardy to a... noncompliance with the TERA or a Federal law has caused imminent jeopardy to a physical trust asset....

  10. 9 CFR 381.224 - Designation of States under section 11 of the Act; application of sections of the Act and the...

    2010-01-01

    ... and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION... or for commerce) in (1) the business of slaughtering any poultry or processing, freezing, packaging, or labeling any poultry carcasses, or parts or products thereof, for use as human food or animal...

  11. Florence Nightingale at First Hand Lynn McDonald Florence Nightingale at First Hand Continuum UK £14.99 224pp 9781441132550 9781441132550 [Formula: see text].

    2011-02-01

    WRITINGS ON Florence nightingale offer two contrasting views of her life. the first is that she was a formidable and highly influential woman, with enlightened views about disease prevention, the care of sick people and the role of professionally trained nurses. the alternative view is that she was a flawed Victorian hero, who enjoyed celebrity status in her lifetime but whose achievements were overestimated.

  12. 2-(2,4-Dichlorophenyl-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylacetamide

    B. Narayana

    2013-01-01

    Full Text Available In the crystal structure of the title compound, C19H17Cl2N3O2, the molecules form dimers of the R22(10 type through N—H...O hydrogen bonding. As a result of steric repulsion, the amide group is rotated with respect to both the dichlorophenyl and 2,3-dihydro-1H-pyrazol-4-yl rings, making dihedral angles of 80.70 (13 and 64.82 (12°, respectively. The dihedral angle between the dichlorophenyl and 2,3-dihydro-1H-pyrazol-4-yl rings is 48.45 (5° while that between the 2,3-dihydro-1H-pyrazol-4-yl and phenyl rings is 56.33 (6°.

  13. Commercial thinning of mature lodgepole pine to reduce susceptibility to mountain pine beetle. FRDA report No. 224, and FERIC special report No. SR-94

    Mitchell, J.L.

    1994-12-31

    This report presents results of a study conducted to examine the effect of commercial thinning and fertilizing of lodgepole pine on attack by mountain pine beetle (Dendroctonus ponderosa Hopk.). At three study sites in the Cranbrook and Invermere Forest Districts of British Columbia, the researchers compared three harvesting treatments to an uncut control: a clearcut and commercial thins leaving trees at about 4- or 5-meter spacings. Equipment used included conventional hand-falling plus line skidders and crawler tractors, or mechanical systems including a feller-buncher, grapple-skidder, and excavator-mounted processor. The report documents the productivity and costs of the commercial thinning and clearcut harvesting operations, and compares the productivity of the equipment and practices used during the harvesting phase on each treatment. It also examines the operational feasibility of commercial thinning.

  14. Submarine groundwater discharge revealed by radium isotopes (Ra-223 and Ra-224 near a paleochannel on the Southern Brazilian continental shelf

    Karina Kammer Attisano

    2013-09-01

    Full Text Available Submarine Groundwater Discharge (SGD has been recognized as an important component of the ocean-continent interface. The few previous studies in Brazil have focused on nearshore areas. This paper explores SGD on the Southern Brazilian Continental Shelf using multiple lines of evidence that include radium isotopes, dissolved nutrients, and water mass observations. The results indicated that SGD may be occurring on the Continental Shelf in the Albardão region, near a paleochannel located 50 km offshore. This paleochannel may thus be a preferential pathway for the delivery of nutrient- and metal-enriched groundwater and porewater into continental shelf waters.

  15. Phenotype-gene: 399 [Arabidopsis Phenome Database[Archive

    Full Text Available 399 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1396i increased fluorescence...p://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17601825i increased fluorescence for quantity of chlo

  16. Phenotype-gene: 400 [Arabidopsis Phenome Database[Archive

    Full Text Available 400 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1397i increased fluorescence...1737-46. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17971335i increased fluorescence for quan

  17. Phenotype abnormality: 129 [Arabidopsis Phenome Database[Archive

    Full Text Available 129 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u635i decreased efficiency...://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u38i ... decreased efficiency ... growth ...

  18. Phenotype-gene: 398 [Arabidopsis Phenome Database[Archive

    Full Text Available 398 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1395i increased efficiency...ar. Plant Cell 17(3):987-99. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15722464i increased efficiency

  19. Phenotype-gene: 48 [Arabidopsis Phenome Database[Archive

    Full Text Available 48 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1047i decreased efficiency...98-509. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16679457i decreased efficiency during proc

  20. Phenotype abnormality: 132 [Arabidopsis Phenome Database[Archive

    Full Text Available 132 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u638i decreased efficiency...atment http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u38i ... decreased efficiency ... organ development ...

  1. Phenotype-gene: 72 [Arabidopsis Phenome Database[Archive

    Full Text Available 72 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1071i decreased efficiency... J. Exp. Bot. 58(8):2181-91. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17519351i decreased efficiency

  2. Phenotype-gene: 66 [Arabidopsis Phenome Database[Archive

    Full Text Available 66 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1065i decreased efficiency... Sep. Plant Cell 17(9):2454-72. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16055636i decreased efficiency

  3. Phenotype-gene: 58 [Arabidopsis Phenome Database[Archive

    Full Text Available 58 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1057i decreased efficiency...17(2):256-68. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u12533513i decreased efficiency durin

  4. Phenotype abnormality: 154 [Arabidopsis Phenome Database[Archive

    Full Text Available 154 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u660i decreased efficiency...ent of blue light regimen http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u29i root ... decreased efficiency ...

  5. Phenotype-gene: 55 [Arabidopsis Phenome Database[Archive

    Full Text Available 55 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1054i decreased efficiency...iol. 47(10):1437-41. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16980702i decreased efficiency

  6. Phenotype-gene: 45 [Arabidopsis Phenome Database[Archive

    Full Text Available 45 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1044i decreased efficiency...ysiol. 141(1):97-107. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16543410i decreased efficiency

  7. Phenotype abnormality: 127 [Arabidopsis Phenome Database[Archive

    Full Text Available 127 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u633i decreased efficiency...gars http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u28i ... 0 seed germination stage ... decreased efficiency ... growth ...

  8. Phenotype abnormality: 136 [Arabidopsis Phenome Database[Archive

    Full Text Available 136 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u642i decreased efficiency... http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u34i ... decreased efficiency ...

  9. Phenotype-gene: 80 [Arabidopsis Phenome Database[Archive

    Full Text Available 80 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1079i decreased efficiency...nt Cell 17(2):502-24. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15659634i decreased efficiency

  10. Phenotype-gene: 63 [Arabidopsis Phenome Database[Archive

    Full Text Available 63 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1062i decreased efficiency...:163-81. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17220200i decreased efficiency for trait

  11. Phenotype-gene: 64 [Arabidopsis Phenome Database[Archive

    Full Text Available 64 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1063i decreased efficiency...5 Oct. Plant Cell 17(10):2633-46. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16141450i decreased efficiency

  12. Phenotype abnormality: 302 [Arabidopsis Phenome Database[Archive

    Full Text Available 302 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u807i increased efficiency...gth regimen http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u40i ... increased efficiency ... growth ...

  13. Phenotype-gene: 53 [Arabidopsis Phenome Database[Archive

    Full Text Available 53 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1052i decreased efficiency...r. Plant J. 34(2):187-203. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u12694594i decreased efficiency

  14. Phenotype-gene: 56 [Arabidopsis Phenome Database[Archive

    Full Text Available 56 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1055i decreased efficiency...al. 2003 Apr. Plant J. 34(2):187-203. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u12694594i decreased efficiency

  15. Phenotype abnormality: 128 [Arabidopsis Phenome Database[Archive

    Full Text Available 128 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u634i decreased efficiency...t intensity regimen http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u33i ... decreased efficiency ... growth ...

  16. Phenotype-gene: 60 [Arabidopsis Phenome Database[Archive

    Full Text Available 60 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1059i decreased efficiency...:433-44. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17329563i decreased efficiency during pro

  17. Phenotype-gene: 754 [Arabidopsis Phenome Database[Archive

    Full Text Available 754 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u930i abnormal for trait of behavior..._ria224i/cria224u4ria224u17139246i abnormal for trait of behavioral quality in or

  18. Phenotype-gene: 743 [Arabidopsis Phenome Database[Archive

    Full Text Available 743 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u919i abnormal for trait of behavior...a224i/cria224u4ria224u17376810i abnormal for trait of behavioral quality in organ

  19. Phenotype-gene: 753 [Arabidopsis Phenome Database[Archive

    Full Text Available 753 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u929i abnormal for trait of behavior...tadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u12694594i abnormal for trait of behavior

  20. Phenotype-gene: 506 [Arabidopsis Phenome Database[Archive

    Full Text Available 506 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1503i lethal (sensu genetics...ant J. 42(5):720-30. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15918885i lethal (sensu genetics

  1. Phenotype-gene: 508 [Arabidopsis Phenome Database[Archive

    Full Text Available 508 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1505i lethal (sensu genetics...ant J. 42(5):720-30. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15918885i lethal (sensu genetics

  2. Phenotype-gene: 522 [Arabidopsis Phenome Database[Archive

    Full Text Available 522 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1519i lethal (sensu genetics...):2033-47. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16040657i lethal (sensu genetics) in pe

  3. Phenotype-gene: 510 [Arabidopsis Phenome Database[Archive

    Full Text Available 510 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1507i lethal (sensu genetics...ant J. 42(5):720-30. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15918885i lethal (sensu genetics

  4. Phenotype-gene: 521 [Arabidopsis Phenome Database[Archive

    Full Text Available 521 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1518i lethal (sensu genetics... Chem. 283(36):24608-16. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18593701i lethal (sensu genetics

  5. Phenotype-gene: 507 [Arabidopsis Phenome Database[Archive

    Full Text Available 507 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1504i lethal (sensu genetics...c. Plant Cell 16(12):3400-12. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15539473i lethal (sensu genetics

  6. Phenotype-gene: 519 [Arabidopsis Phenome Database[Archive

    Full Text Available 519 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1516i lethal (sensu genetics... Chem. 283(36):24608-16. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18593701i lethal (sensu genetics

  7. Phenotype abnormality: 408 [Arabidopsis Phenome Database[Archive

    Full Text Available 408 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u912i lethal (sensu genetics...tment http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u38i ... stem elongation stage ... lethal (sensu genetics) ...

  8. Phenotype-gene: 509 [Arabidopsis Phenome Database[Archive

    Full Text Available 509 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1506i lethal (sensu genetics...ant J. 42(5):720-30. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15918885i lethal (sensu genetics

  9. Phenotype-gene: 513 [Arabidopsis Phenome Database[Archive

    Full Text Available 513 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1510i lethal (sensu genetics...ant J. 42(5):720-30. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15918885i lethal (sensu genetics

  10. Phenotype-gene: 515 [Arabidopsis Phenome Database[Archive

    Full Text Available 515 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1512i lethal (sensu genetics...ant J. 42(5):720-30. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15918885i lethal (sensu genetics

  11. Phenotype-gene: 512 [Arabidopsis Phenome Database[Archive

    Full Text Available 512 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1509i lethal (sensu genetics...ant J. 42(5):720-30. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15918885i lethal (sensu genetics

  12. Phenotype-gene: 520 [Arabidopsis Phenome Database[Archive

    Full Text Available 520 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1517i lethal (sensu genetics... Chem. 283(36):24608-16. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18593701i lethal (sensu genetics

  13. Phenotype-gene: 518 [Arabidopsis Phenome Database[Archive

    Full Text Available 518 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1515i lethal (sensu genetics...p://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15918885i lethal (sensu genetics) in organ named seed

  14. Phenotype-gene: 511 [Arabidopsis Phenome Database[Archive

    Full Text Available 511 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1508i lethal (sensu genetics...ant J. 42(5):720-30. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15918885i lethal (sensu genetics

  15. Phenotype abnormality: 270 [Arabidopsis Phenome Database[Archive

    Full Text Available 270 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u775i elongated hypocotyl in environment... of light regimen in environment of light regimen http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u34i hypocotyl ... elongated ...

  16. Phenotype abnormality: 98 [Arabidopsis Phenome Database[Archive

    Full Text Available 98 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u604i colorless whole plant in presen...ce of sucrose in presence of sucrose http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u48i whole plant ... colorless ...

  17. Phenotype-gene: 190 [Arabidopsis Phenome Database[Archive

    Full Text Available 190 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1188i decreased responsivity under influence...:471-81. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18263776i decreased responsivity under influence

  18. Phenotype-gene: 456 [Arabidopsis Phenome Database[Archive

    Full Text Available 456 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1453i increased resistance under influence...80. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16540482i increased resistance under influence

  19. Phenotype-gene: 455 [Arabidopsis Phenome Database[Archive

    Full Text Available 455 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1452i increased resistance under influence...1853-60. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17293438i increased resistance under influence

  20. Phenotype-gene: 457 [Arabidopsis Phenome Database[Archive

    Full Text Available 457 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1454i increased resistance under influence...http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15181201i increased resistance under influence of

  1. Phenotype-gene: 461 [Arabidopsis Phenome Database[Archive

    Full Text Available 461 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1458i increased responsivity under influence...-66. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u14729919i increased responsivity under influence

  2. Phenotype-gene: 475 [Arabidopsis Phenome Database[Archive

    Full Text Available 475 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1472i increased sensitivity under influence...//metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17355438i increased sensitivity under influence of lead

  3. Phenotype-gene: 196 [Arabidopsis Phenome Database[Archive

    Full Text Available 196 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1194i decreased sensitivity under influence... http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17347412i decreased sensitivity under influence o

  4. Phenotype-gene: 817 [Arabidopsis Phenome Database[Archive

    Full Text Available 817 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u993i arrhythmic in e...17(3):791-803. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15705949i arrhythmic in environment

  5. Phenotype-gene: 514 [Arabidopsis Phenome Database[Archive

    Full Text Available 514 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1511i lethal (sensu gene...ant J. 42(5):720-30. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15918885i lethal (sensu genet

  6. Phenotype-gene: 801 [Arabidopsis Phenome Database[Archive

    Full Text Available 801 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u977i absence for qua.... http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16829592i absence for quantity of fruit in organ

  7. Phenotype-gene: 802 [Arabidopsis Phenome Database[Archive

    Full Text Available 802 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u978i absence for qua...7. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17960244i absence for quantity of root in organ

  8. Phenotype-gene: 791 [Arabidopsis Phenome Database[Archive

    Full Text Available 791 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u967i abnormal for trait of morph...):272-84. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16112663i abnormal for trait of morpholo

  9. Phenotype-gene: 768 [Arabidopsis Phenome Database[Archive

    Full Text Available 768 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u944i abnormal for trait of morph...p://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u12750345i abnormal for trait of morphology in organ n

  10. Phenotype-gene: 778 [Arabidopsis Phenome Database[Archive

    Full Text Available 778 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u954i abnormal for trait of morph...:282-4. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16015335i abnormal for trait of morphology

  11. Phenotype-gene: 558 [Arabidopsis Phenome Database[Archive

    Full Text Available 558 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1555i non-functional ph...73-85. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16024589i non-functional phloem or xylem hi

  12. Phenotype-gene: 499 [Arabidopsis Phenome Database[Archive

    Full Text Available 499 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1496i insufficient for quantity of chloroph... 16(12):3400-12. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15539473i insufficient for quantity of chloroph

  13. Phenotype-gene: 798 [Arabidopsis Phenome Database[Archive

    Full Text Available 798 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u974i abnormal for trait of morph...-66. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16531491i abnormal for trait of morphology in

  14. Phenotype-gene: 33 [Arabidopsis Phenome Database[Archive

    Full Text Available 33 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1032i decreased density of chloroph...041-52. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17335513i decreased density of chlorophyll

  15. Phenotype-gene: 767 [Arabidopsis Phenome Database[Archive

    Full Text Available 767 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u943i abnormal for trait of morph...):627-37. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u12699618i abnormal for trait of morpholo

  16. Phenotype-gene: 505 [Arabidopsis Phenome Database[Archive

    Full Text Available 505 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1502i kinked for trait of morph...66. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16531491i kinked for trait of morphology in or

  17. Phenotype-gene: 792 [Arabidopsis Phenome Database[Archive

    Full Text Available 792 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u968i abnormal for trait of morph...2):3548-63. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17189341i abnormal for trait of morpho

  18. Phenotype-gene: 762 [Arabidopsis Phenome Database[Archive

    Full Text Available 762 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u938i abnormal for trait of morph...:1467-81. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15829606i abnormal for trait of morpholo

  19. Phenotype-gene: 775 [Arabidopsis Phenome Database[Archive

    Full Text Available 775 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u951i abnormal for trait of morph...-22. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u19081078i abnormal for trait of morphology in

  20. Phenotype-gene: 797 [Arabidopsis Phenome Database[Archive

    Full Text Available 797 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u973i abnormal for trait of morph...):591-603. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16792691i abnormal for trait of morphol

  1. Phenotype-gene: 776 [Arabidopsis Phenome Database[Archive

    Full Text Available 776 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u952i abnormal for trait of morph...-22. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u19081078i abnormal for trait of morphology in

  2. Phenotype-gene: 790 [Arabidopsis Phenome Database[Archive

    Full Text Available 790 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u966i abnormal for trait of morph...93. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18591352i abnormal for trait of morphology in

  3. Phenotype-gene: 779 [Arabidopsis Phenome Database[Archive

    Full Text Available 779 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u955i abnormal for trait of morph...2-93. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18591352i abnormal for trait of morphology i

  4. Phenotype-gene: 789 [Arabidopsis Phenome Database[Archive

    Full Text Available 789 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u965i abnormal for trait of morph...-24. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15659634i abnormal for trait of morphology in

  5. Phenotype-gene: 788 [Arabidopsis Phenome Database[Archive

    Full Text Available 788 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u964i abnormal for trait of morph...9. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15316111i abnormal for trait of morphology in o

  6. Phenotype-gene: 773 [Arabidopsis Phenome Database[Archive

    Full Text Available 773 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u949i abnormal for trait of morph...-80. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16510519i abnormal for trait of morphology in

  7. Phenotype-gene: 795 [Arabidopsis Phenome Database[Archive

    Full Text Available 795 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u971i abnormal for trait of morph...:353-66. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u14729919i abnormal for trait of morpholog

  8. Phenotype-gene: 562 [Arabidopsis Phenome Database[Archive

    Full Text Available 562 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1559i non-functional response to gravity...ken.jp/db/SciNetS_ria224i/cria224u4ria224u16690816i non-functional response to gravity http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u947i AT1G54990

  9. Phenotype-gene: 526 [Arabidopsis Phenome Database[Archive

    Full Text Available 526 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1523i lethal in environment of aerial habit...riken.jp/db/SciNetS_ria224i/cria224u4ria224u15980259i lethal in environment of aerial habitat http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u916i AT1G80380

  10. Phenotype-gene: 533 [Arabidopsis Phenome Database[Archive

    Full Text Available 533 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1530i low sensitivity toward under influence...nsitivity toward under influence of 1-chloro-2,4-dinitrobenzene http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u921i AT2G34660 ...Plant Cell Physiol. 49(4):557-69. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18325934i low se

  11. Phenotype-gene: 709 [Arabidopsis Phenome Database[Archive

    Full Text Available 709 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u794i serrated leaf m...argin for AT1G20980 Stone Julie M et al. 2005 Mar. Plant J. 41(5):744-54. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u15703061i serrated leaf margin http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u468i AT1G20980

  12. Phenotype-gene: 6 [Arabidopsis Phenome Database[Archive

    Full Text Available 6 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1005i colorless whole ...plant for AT3G04520 Joshi Vijay et al. 2006 Dec. Plant Cell 18(12):3564-75. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u17172352i colorless whole plant http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u602i AT3G04520

  13. Phenotype-gene: 11 [Arabidopsis Phenome Database[Archive

    Full Text Available 11 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1010i colorless whole... plant for AT5G12130 Kwon Kwang-Chul et al. 2008 Aug. Plant J. 55(3):428-42. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u18429937i colorless whole plant http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u602i AT5G12130

  14. Phenotype-gene: 675 [Arabidopsis Phenome Database[Archive

    Full Text Available 675 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u415i disfunctional s...eedling for AT3G50870 Zhao Yuanxiang et al. 2004 Oct. Plant Cell 16(10):2586-600. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u15367721i disfunctional seedling http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u236i AT3G50870

  15. Phenotype-gene: 730 [Arabidopsis Phenome Database[Archive

    Full Text Available 730 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u905i pale seedling f...or AT2G48120 Kovacheva Sabina et al. 2005 Feb. Plant J. 41(3):412-28. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u15659100i pale seedling http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u534i AT2G48120

  16. Phenotype-gene: 637 [Arabidopsis Phenome Database[Archive

    Full Text Available 637 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1634i serrated vascu...lar leaf for AT4G32700 Inagaki Soichi et al. 2006 Apr. Plant Cell 18(4):879-92. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u16517762i serrated vascular leaf http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u975i AT4G32700

  17. Phenotype-gene: 634 [Arabidopsis Phenome Database[Archive

    Full Text Available 634 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1631i roundish leaf ...lamina for AT3G52280 Chua Yii Leng et al. 2005 Sep. Genes Dev. 19(18):2245-54. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u16166385i roundish leaf lamina http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u973i AT3G52280

  18. Phenotype-gene: 491 [Arabidopsis Phenome Database[Archive

    Full Text Available 491 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1488i inpaired growt...h for AT5G58760 Koga Asami et al. 2006 May. Plant Mol. Biol. 61(1-2):227-40. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u16786303i inpaired growth http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u898i AT5G58760

  19. Phenotype-gene: 691 [Arabidopsis Phenome Database[Archive

    Full Text Available 691 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u705i pale green coty...ledon for AT2G36990 Ishizaki Yoko et al. 2005 Apr. Plant J. 42(2):133-44. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u15807777i pale green cotyledon http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u444i AT2G36990

  20. Phenotype-gene: 714 [Arabidopsis Phenome Database[Archive

    Full Text Available 714 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u824i yellow whole pl...ant for AT1G12410 Rudella Andrea et al. 2006 Jul. Plant Cell 18(7):1704-21. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u16766689i yellow whole plant http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u491i AT1G12410

  1. Phenotype-gene: 5 [Arabidopsis Phenome Database[Archive

    Full Text Available 5 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1004i colorless whole ...plant for AT2G15290 Teng Yi-Shan et al. 2006 Sep. Plant Cell 18(9):2247-57. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u16891400i colorless whole plant http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u602i AT2G15290

  2. Phenotype-gene: 636 [Arabidopsis Phenome Database[Archive

    Full Text Available 636 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1633i serrated vascu...lar leaf for AT1G54490 Binder Brad M et al. 2007 Feb. Plant Cell 19(2):509-23. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u17307926i serrated vascular leaf http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u975i AT1G54490

  3. Phenotype-gene: 725 [Arabidopsis Phenome Database[Archive

    Full Text Available 725 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u900i pale seed for A...T4G15560 Kovacheva Sabina et al. 2005 Feb. Plant J. 41(3):412-28. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u15659100i pale seed http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u533i AT4G15560

  4. Phenotype-gene: 567 [Arabidopsis Phenome Database[Archive

    Full Text Available 567 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1564i non-functional... root for AT5G57740 Nodzon Lisa A et al. 2004 Dec. Plant J. 40(6):996-1006. http://metadb.riken.jp/db/SciNetS_ria224i/cria...224u4ria224u15584963i non-functional root http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u948i AT5G57740

  5. Phenotype-gene: 557 [Arabidopsis Phenome Database[Archive

    Full Text Available 557 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1554i non-functional ph.../metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16045474i non-functional phloem or xylem histogenesis http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u943i AT3G55830

  6. Phenotype abnormality: 46 [Arabidopsis Phenome Database[Archive

    Full Text Available 46 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u552i abnormal for trait of behavior.../cria224u2ria224u38i stomatal complex ... abnormal ... response to light stimulus ... behavioral quality

  7. Phenotype-gene: 741 [Arabidopsis Phenome Database[Archive

    Full Text Available 741 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u917i abnormal for trait of behavior...ria224u4ria224u15986216i abnormal for trait of behavioral quality in organ named

  8. Phenotype-gene: 747 [Arabidopsis Phenome Database[Archive

    Full Text Available 747 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u923i abnormal for trait of behavior...4i/cria224u4ria224u12837954i abnormal for trait of behavioral quality in organ na

  9. Phenotype-gene: 755 [Arabidopsis Phenome Database[Archive

    Full Text Available 755 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u931i abnormal for trait of behavior...ria224u4ria224u17148695i abnormal for trait of behavioral quality in organ named

  10. Phenotype-gene: 761 [Arabidopsis Phenome Database[Archive

    Full Text Available 761 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u937i abnormal for trait of duration...ria224u4ria224u17041028i abnormal for trait of duration quality of a process in o

  11. 10 CFR Appendix E to Part 20 - Nationally Tracked Source Thresholds

    2010-01-01

    ... Category 1(TBq) Category 1(Ci) Category 2(TBq) Category 2(Ci) Actinium-227 20 540 0.2 5.4 Americium-241 60... 2 54 Strontium-90 1,000 27,000 10 270 Thorium-228 20 540 0.2 5.4 Thorium-229 20 540 0.2 5.4...

  12. Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225.

    Chen, Xiaoyuan; Ji, Min; Fisher, Darrell R; Wai, Chien M

    1999-09-01

    A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.

  13. I. The metabolic properties of plutonium and allied materials

    Hamilton, J.G.

    1948-05-24

    This report on the metabolic properties of plutonium and related radioactive materials presents experimental information in the following areas: radioautographic studies; tracer studies (with tables of accumulation in tissues) of actinium, radio-zirconium, technetium, radio-rubidium, radio-germanium, beryllium, and cadmium; decontamination and bone metabolism studies; and radio-chemical isolation.

  14. Phenotype abnormality: 236 [Arabidopsis Phenome Database[Archive

    Full Text Available 236 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u742i decreased susce...ptibility in response to organism Agrobacterium ... Agrobacterium ... decreased susceptibility toward ...

  15. Phenotype abnormality: 231 [Arabidopsis Phenome Database[Archive

    Full Text Available 231 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u737i decreased speed... in organ named seedling during process named growth ... seedling ... decreased speed ... growth ...

  16. Phenotype abnormality: 152 [Arabidopsis Phenome Database[Archive

    Full Text Available 152 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u658i decreased efficiency... in organ named root during process named growth ... root ... decreased efficiency ... growth ...

  17. Phenotype abnormality: 376 [Arabidopsis Phenome Database[Archive

    Full Text Available 376 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u881i increased sensitivity... toward in situation of high temperature ... increased temperature increased sensitivity toward ...

  18. Phenotype abnormality: 311 [Arabidopsis Phenome Database[Archive

    Full Text Available 311 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u816i increased efficiency during process... named seed dormancy process ... increased efficiency ... seed dormancy process ...

  19. Phenotype abnormality: 135 [Arabidopsis Phenome Database[Archive

    Full Text Available 135 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u641i decreased efficiency during process... named seed dormancy process ... decreased efficiency ... seed dormancy process ...

  20. Phenotype abnormality: 213 [Arabidopsis Phenome Database[Archive

    Full Text Available 213 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u719i decreased sensitivity toward under influ...ence of brassinosteroid ... decreased sensitivity toward ... brassinosteroid ...

  1. Phenotype abnormality: 36 [Arabidopsis Phenome Database[Archive

    Full Text Available 36 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u542i abnormal for trait of behavioral quality...tyledon ... abnormal ... anatomical structure arrangement ... behavioral quality

  2. Phenotype abnormality: 41 [Arabidopsis Phenome Database[Archive

    Full Text Available 41 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u547i abnormal for trait of behavioral quality...ganelle ... abnormal ... anatomical structure arrangement ... behavioral quality

  3. Phenotype abnormality: 38 [Arabidopsis Phenome Database[Archive

    Full Text Available 38 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u544i abnormal for trait of behavioral quality...idermis ... abnormal ... anatomical structure arrangement ... behavioral quality

  4. Phenotype abnormality: 299 [Arabidopsis Phenome Database[Archive

    Full Text Available 299 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u804i increased effic...iency during process named defense response, incompatible interaction ... increased efficiency ...

  5. Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice

    Colorectal cancer accounts for 130,000 new cancer cases and approximately 56,000 deaths each year in the United States, and it is estimated that half of Western population can expect to develop at least one colorectal tumor by age 70. MicroRNAs (miRNAs) are small RNA molecules, DNA products, functio...

  6. Pertactin-negative Bordetella pertussis strains in Canada: characterization of a dozen isolates based on a survey of 224 samples collected in different parts of the country over the last 20 years

    Raymond S.W. Tsang

    2014-11-01

    Conclusions: As reported elsewhere, pertactin-negative B. pertussis has emerged in Canada in recent years, notably in 2012. This coincided with an increase in pertussis activity in Canada. A further systematic study with a larger geographical representative sample is required to determine how these vaccine-negative strains may contribute to the overall changing epidemiology of pertussis in Canada.

  7. Keystone Symposia "ncRNAs in Development and Cancer", Vancouver, Canada: Increased release of exosomes and export of invasion-modulating miRNAs miR921, -23b, -and -224 from metastatic urothelial carcinoma cells

    Ostenfeld, Marie Stampe; Jeppesen, Dennis Kjølhede; Laurberg, Jens Reumert

    2013-01-01

    Cancer cells secrete soluble factors and various extracellular vesicles, including exosomes, into their tissue microenvironment. The secretion of exosomes is speculated to facilitate local invasion and increase the propensity of tumors to form distant metastases. Here we present a characterization...... of exosome vesicles from isogenic urothelial carcinoma cell lines, with different metastatic propensity by western blotting, electron microscopy, nanoparticle tracking analysis, dynamic light scattering, and profiling of 671 miRNAs by qRT-PCR. An increase in the number of multivesicular bodies and exosomes...... was observed for metastatic FL3 cells compared to isogenic non-metastatic T24 cells. The release was significantly inhibited by knockdown of Rab27b and pharmacological inhibition of nsmase2 by GW4869. miRNA profiling was conducted on parental cells and their secreted exosomes. Here, selective export of miR921...

  8. André Charrak, Contingence et nécessité des lois de la nature. La philosophie seconde des Lumières, Paris, Vrin, 2006, 224 pages, 26 €.

    Raphaële Andrault

    2009-04-01

    Full Text Available Quel est le statut des lois de la nature ? Telle est la question posée dans ce livre d’André Charrak. L’auteur montre que la philosophie des Lumières envisage le problème de la connaissance sous l’angle de « l’application des principes aux phénomènes et des sciences les unes aux autres » (p. 199 et qu’il existe un lien direct entre la possibilité de l’application de la mathématique à la physique dans les savoirs positifs et les partis pris explicites sur le statut modal des lois du mouvement...

  9. Posttranslational oxidative modification of (R)-2-(2,4-dichlorophenoxy)propionate/α-ketoglutarate-dependent dioxygenases (RdpA) leads to improved degradation of 2,4-dichlorophenoxyacetate (2,4-D)

    Leibeling, S.; Maeß, M.B.; Centler, F.; Kleinsteuber, S.; von Bergen, M.; Thullner, M.; Harms, H.; Müller, R.H.

    2013-01-01

    Microbial activities and the versatility gained through adaptation to xenobiotic compounds are the main biological forces to counteract environmental pollution. The current results present a new adaptive mechanism that is mediated through posttranslational modifications. Strains of Delftia acidovora

  10. VLT/UVES observations of extremely strong intervening damped Lyman-alpha systems: Molecular hydrogen and excited carbon, oxygen and silicon at log N(HI)=22.4

    Noterdaeme, P; Rahmani, H; Petitjean, P; Pâris, I; Ledoux, C; Gupta, N; López, S

    2015-01-01

    We present a detailed analysis of three extremely strong intervening DLAs (log N(HI)>=21.7) observed towards quasars with VLT/UVES. We measure overall metallicities of [Zn/H]~-1.2, -1.3 and -0.7 at respectively zabs=2.34 towards SDSS J2140-0321 (log N(HI) = 22.4+/-0.1), zabs=3.35 towards SDSS J1456+1609 (log N(HI) = 21.7+/-0.1) and zabs=2.25 towards SDSS J0154+1935 (log N(HI) = 21.75+/-0.15). We detect H2 towards J2140-0321 (log N(H2) = 20.13+/-0.07) and J1456+1609 (log N(H2) = 17.10+/-0.09) and argue for a tentative detection towards J0154+1935. Absorption from the excited fine-structure levels of OI, CI and SiII are detected in the system towards J2140-0321, that has the largest HI column density detected so far in an intervening DLA. This is the first detection of OI fine-structure lines in a QSO-DLA, that also provides us a rare possibility to study the chemical abundances of less abundant atoms like Co and Ge. Simple single phase photo-ionisation models fail to reproduce all the observed quantities. Inst...

  11. Book Review: The future of spacetime. Stephen William Hawking (ed.); Kip S. Thorne, Igor Novikov, Timothy Ferris, Alan Lightman, and Richard Price, W.W. Norton & Company, 2002, 224 pp., US 25.95, ISBN 0393020223

    Smeenk, Chris

    The study of Einstein's theory of general relativity experienced a renaissance beginning in the early 1960s. Prior to this resurgence of interest, general relativity was isolated from mainstream physics-admired for its elegance, perhaps, but only from a distance. The generation of students who risked their careers by entering this neglected field has now reached the age of festschrifts. In June of 2000, Caltech hosted "Kipfest," a conference in honor of Kip Thorne's 60th birthday. Thorne started graduate school at Princeton in 1962 and began research in general relativity under John Wheeler's guidance in the heady early days of the renaissance. Since then, he has played a prominent role in general relativity: as co-author of the influential textbook Gravitation, as a leader in research regarding astrophysical applications of Einstein's theory, and as a co-founder and chief advocate for the Laser Interferometer Gravitational Wave Observatory (LIGO), to mention a few aspects of his far-reaching work. "Kipfest" included 14 speakers discussing fields to which Thorne has contributed. But the conference also reflected Thorne's long-standing commitment to communicating science to a general audience: Igor Novikov, Stephen Hawking, Timothy Ferris, and Alan Lightman gave popular talks at "Kipfest," with Thorne himself tricked into delivering a fifth. The Future of Spacetime gathers adaptations of these five lectures, along with a lengthy introductory essay by Richard Price.

  12. Florence nightingale at first hand Lynn McDonald Florence nightingale at first hand Continuum UK 224pp £14.99 978 1 4411 3255 0 1441132554 [Formula: see text].

    2010-09-01

    Writings on Florence Nightingale offer two contrasting views of her life and achievements. The first is that she was a formidable, highly influential woman with enlightened views about disease prevention, the care of sick people and the role of professionally trained nurses. The alternative view is that she was a flawed Victorian hero, who enjoyed celebrity status in her lifetime, but whose achievements were over-estimated.

  13. Synthesis, coordination and biological aspects of organotin(IV derivatives of 4-[(2,4-dinitrophenylamino]-4-oxo-2-butenoic acid and 2-{[(2,4-dinitrophenylamino]carbonyl}benzoic acid

    KHADIJA SHAHID

    2009-02-01

    Full Text Available New series of organotin(IV complexes of aniline derivatives, R2SnL2 and R3SnL [where R = Me, n-Bu, Ph, n-Oct] have been synthesized by the reaction of HL1 and HL2 with respective organotin halides or oxides. Experimental details for the preparation and characterization (including elemental analysis, IR and multinuclear NMR (1H-, 13C- and 119Sn- spectra in CDCl3 and EI mass spectra of both series are provided. The binding sites of the ligands were identified by means of FTIR spectroscopic measurements. It was found that in all cases the organotin(IV moiety reacts with the oxygen of COO– group to form new complexes. In the diorganotin complexes, the COO– group is coordinated to the organotin(IV centres in a bidentate manner in the solid state. The 119Sn NMR data and the nJ(13C‑119/117Sn coupling constant support the tetrahedral coordination geometry of the organotin complexes in non-coordinating solvents. Biological activities (antibacterial, antifungal, cytotoxicity, antileishmanial and insecticidal of these compounds are also reported.

  14. Phenotype-gene: 401 [Arabidopsis Phenome Database[Archive

    Full Text Available 401 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1398i increased fluorescence... for quantity of chlorophyll for AT5G66570 ... increased fluorescence for quantity of chlorophyll http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u823i AT5G66570

  15. Phenotype-gene: 90 [Arabidopsis Phenome Database[Archive

    Full Text Available 90 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1089i decreased efficiency...tl. Acad. Sci. U.S.A. 102(21):7754-9. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15894610i decreased efficiency

  16. Phenotype-gene: 82 [Arabidopsis Phenome Database[Archive

    Full Text Available 82 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1081i decreased efficiency...ivier et al. 2007 Dec. Plant J. 52(5):850-64. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17883375i decreased efficienc

  17. Phenotype-gene: 736 [Arabidopsis Phenome Database[Archive

    Full Text Available 736 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u912i abnormal for trait of behavior...eb. Science 307(5712):1111-3. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15618487i abnormal for trait of behavior

  18. Phenotype-gene: 737 [Arabidopsis Phenome Database[Archive

    Full Text Available 737 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u913i abnormal for trait of behavior...c. EMBO J. 25(24):5907-18. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17139246i abnormal for trait of behavior

  19. Phenotype-gene: 735 [Arabidopsis Phenome Database[Archive

    Full Text Available 735 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u911i abnormal for trait of behavior...t Physiol. 142(2):564-73. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16891550i abnormal for trait of behavior

  20. Phenotype-gene: 746 [Arabidopsis Phenome Database[Archive

    Full Text Available 746 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u922i abnormal for trait of behavior...t al. 2005 Feb. Plant J. 41(3):364-75. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15659096i abnormal for trait of beha...vioral quality in organ named hypocotyl during process n

  1. Phenotype-gene: 516 [Arabidopsis Phenome Database[Archive

    Full Text Available 516 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1513i lethal (sensu genetics...t al. 2008 Aug. Plant J. 55(3):428-42. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18429937i lethal (sensu genetics

  2. Phenotype-gene: 523 [Arabidopsis Phenome Database[Archive

    Full Text Available 523 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1520i lethal (sensu genetics...Sci. U.S.A. 101(20):7821-6. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15136745i lethal (sensu genetics

  3. Phenotype abnormality: 410 [Arabidopsis Phenome Database[Archive

    Full Text Available 410 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u914i lethal (sensu genetics...) in organ named seedling in absense of carbon in absense of carbon http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u27i seedling ... lethal (sensu genetics) ...

  4. Phenotype-gene: 525 [Arabidopsis Phenome Database[Archive

    Full Text Available 525 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1522i lethal (sensu genetics...Sci. U.S.A. 101(20):7821-6. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15136745i lethal (sensu genetics

  5. Phenotype-gene: 524 [Arabidopsis Phenome Database[Archive

    Full Text Available 524 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1521i lethal (sensu genetics...Sci. U.S.A. 101(20):7821-6. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15136745i lethal (sensu genetics

  6. Phenotype abnormality: 403 [Arabidopsis Phenome Database[Archive

    Full Text Available 403 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u907i involute hypocotyl in environment... of far red light regimen in environment of far red light regimen http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u32i hypocotyl ... involute ...

  7. Phenotype abnormality: 271 [Arabidopsis Phenome Database[Archive

    Full Text Available 271 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u776i elongated hypocotyl in environment... of short day length regimen in environment of short day length regimen http://metadb.riken.jp/db/SciNetS_ria224i/cria224u2ria224u40i hypocotyl ... elongated ...

  8. Phenotype-gene: 777 [Arabidopsis Phenome Database[Archive

    Full Text Available 777 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u953i abnormal for trait... of morphology in organ named root for AT5G60920 ... abnormal for trait of morphology in organ named root http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u568i AT5G60920

  9. Phenotype-gene: 766 [Arabidopsis Phenome Database[Archive

    Full Text Available 766 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u942i abnormal for trait of morph...i. U.S.A. 104(47):18836-41. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18000056i abnormal for trait of morph

  10. Phenotype-gene: 772 [Arabidopsis Phenome Database[Archive

    Full Text Available 772 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u948i abnormal for trait of morph...ology in organ named leaf lamina for AT1G55255 Fleury Delphine et al. 2007 Feb. Plant Cell 19(2)...:417-32. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17329565i abnormal for trait of morpholog

  11. Phenotype-gene: 793 [Arabidopsis Phenome Database[Archive

    Full Text Available 793 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u969i abnormal for trait of morph...ology in organ named vascular leaf for AT2G35110 Li Yunhai et al. 2004 Nov. Plant Physiol. 136(3...):3616-27. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15516496i abnormal for trait of morphol

  12. Phenotype-gene: 769 [Arabidopsis Phenome Database[Archive

    Full Text Available 769 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u945i abnormal for trait of morph...ology in organ named inflorescence for AT2G35110 Li Yunhai et al. 2004 Nov. Plant Physiol. 136(3...):3616-27. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15516496i abnormal for trait of morphol

  13. Phenotype-gene: 763 [Arabidopsis Phenome Database[Archive

    Full Text Available 763 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u939i abnormal for trait of morph.... U.S.A. 103(17):6759-64. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16617119i abnormal for trait of morph

  14. Phenotype-gene: 785 [Arabidopsis Phenome Database[Archive

    Full Text Available 785 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u961i abnormal for trait of morph...U.S.A. 103(17):6759-64. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16617119i abnormal for trait of morph

  15. Phenotype-gene: 794 [Arabidopsis Phenome Database[Archive

    Full Text Available 794 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u970i abnormal for trait of morph...ology in organ named vascular leaf for AT2G44950 Fleury Delphine et al. 2007 Feb. Plant Cell 19(...2):417-32. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17329565i abnormal for trait of morphol

  16. Phenotype-gene: 771 [Arabidopsis Phenome Database[Archive

    Full Text Available 771 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u947i abnormal for trait of morph...ology in organ named leaf lamina for AT1G55250 Fleury Delphine et al. 2007 Feb. Plant Cell 19(2)...:417-32. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17329565i abnormal for trait of morpholog

  17. Phenotype-gene: 770 [Arabidopsis Phenome Database[Archive

    Full Text Available 770 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u946i abnormal for trait of morph...ology in organ named inflorescence for AT5G18410 Li Yunhai et al. 2004 Nov. Plant Physiol. 136(3...):3616-27. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15516496i abnormal for trait of morphol

  18. Phenotype-gene: 796 [Arabidopsis Phenome Database[Archive

    Full Text Available 796 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u972i abnormal for trait of morph...ology in organ named vascular leaf for AT5G18410 Li Yunhai et al. 2004 Nov. Plant Physiol. 136(3...):3616-27. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15516496i abnormal for trait of morphol

  19. Phenotype-gene: 787 [Arabidopsis Phenome Database[Archive

    Full Text Available 787 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u963i abnormal for trait of morph...03 Jul. Plant Cell 15(7):1632-45. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u12837952i abnormal for trait of morph

  20. Phenotype-gene: 786 [Arabidopsis Phenome Database[Archive

    Full Text Available 786 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u962i abnormal for trait of morph...03 Jul. Plant Cell 15(7):1632-45. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u12837952i abnormal for trait of morph

  1. Phenotype-gene: 757 [Arabidopsis Phenome Database[Archive

    Full Text Available 757 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u933i abnormal for trait of behavior...4u4ria224u15908594i abnormal for trait of behavioral quality in organ named whole

  2. Phenotype-gene: 752 [Arabidopsis Phenome Database[Archive

    Full Text Available 752 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u928i abnormal for trait of behavior...a224u16055636i abnormal for trait of behavioral quality in organ named stamen dur

  3. Phenotype-gene: 742 [Arabidopsis Phenome Database[Archive

    Full Text Available 742 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u918i abnormal for trait of behavior...ia224u16299182i abnormal for trait of behavioral quality in organ named cotyledon

  4. Phenotype-gene: 758 [Arabidopsis Phenome Database[Archive

    Full Text Available 758 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u934i abnormal for trait of behavior...4u4ria224u15908594i abnormal for trait of behavioral quality in organ named whole

  5. Phenotype-gene: 744 [Arabidopsis Phenome Database[Archive

    Full Text Available 744 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u920i abnormal for trait of behavior...a224u16055636i abnormal for trait of behavioral quality in organ named flower dur

  6. Phenotype-gene: 61 [Arabidopsis Phenome Database[Archive

    Full Text Available 61 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1060i decreased efficiency...24u17337534i decreased efficiency during process named stomatal movement in envir...lkumar et al. 2007 May. Plant Physiol. 144(1):82-93. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria2

  7. Study of the origin of elements of the uranium-235 family observed in excess in the vicinity of the experimental nuclear EL4 reactor under dismantling. Lessons got at this day and conclusions; Etude de l'origine des elements de la famille de l'uranium-235 observes en exces dans les environs du reacteur nucleaire experimental EL4 en cours de demantelement. Enseignements retires a ce jour et conclusion

    NONE

    2007-07-01

    This study resumes the discovery of an excess of actinium 227 found around by EL4 nuclear reactor actually in dismantling. The search for the origin of this excess revealed a real inquiry of investigation during three years. Because a nuclear reactor existed in this area a particular attention will have concerned this region. The doubt became the line of conduct to find the answer to the human or natural origin of this excess. Finally and against any evidence, it appears that the origin of this phenomenon was natural, consequence of the particular local geology. The detail of the different investigations is given: search of a possible correlation with the composition of elevations constituent of lanes, search (and underlining) of new sites in the surroundings of the Rusquec pond and the Plouenez station, study of the atmospheric deposits under winds of the nuclear power plant and in the east direction, search of a possible relationship with the gaseous effluents of the nuclear power plant in the past, historical study of radioactive effluents releases in the fifty last years by the analysis of the sedimentary deposits in the Saint-Herbiot reservoir, search of a possible correlation between the excess of actinium 227 and the nuclear power plant activity; search of a possible correlation with a human activity without any relationship with the nuclear activities, search of a correlation with the underground waters, search of a correlation with the geological context, collect of information on the possible transfers in direction of the food chain, determination of the radiological composition of the underground waters ( not perturbed by human activity), search of the cause of an excess of actinium 227 in the old channel of liquid effluents release of the nuclear power plant. The results are given and discussed. And contrary to all expectations the origin of the excess of actinium 227 is completely natural. (N.C.)

  8. Behaviour of uranium series radionuclides in surface water (Crouzille, Limousin). Geochemical implications; Comportement des radionucleides des familles de l'uranium dans les eaux superficielles du site de la Crouzille (Limousin): implications geochimiques

    NONE

    2008-06-15

    Understanding natural radionuclides behaviour in surface water is a required step to achieve uranium mine rehabilitation and preserve water quality. The first objective of this thesis is to determine which are the radionuclides sources in a drinking water reservoir. The second objective is to improve the knowledge about the behaviour of uranium series radionuclides, especially actinium. The investigated site is a brook (Sagnes, Limousin, France) which floods a peat bog contaminated by a former uranium mine and which empties into the Crouzille lake. It allows studying radionuclides transport in surface water and radionuclides retention through organic substance or water reservoir. Radionuclides distribution in particulate, colloidal and dissolved phases is determined thanks to ultra-filtrations. Gamma spectrometry allows measuring almost all natural radionuclides with only two counting stages. However, low activities of {sup 235}U series radionuclides impose the use of very low background well-type Ge detectors, such as those of the Underground Laboratory of Modane (France). Firstly, this study shows that no or few radionuclides are released by the Sagnes peat bog, although its radioactivity is important. Secondly, it provides details on the behaviour of uranium series radionuclides in surface water. More specifically, it provides the first indications of actinium solubility in surface water. Actinium's behaviour is very close to uranium's even if it is a little less soluble. (author)

  9. Phenotype-gene: 424 [Arabidopsis Phenome Database[Archive

    Full Text Available 424 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1421i increased number of axillary inflores...cence bud in organ named inflorescence for AT5G15230 Roxrud Ingrid et al. 2007 Mar. P...ed number of axillary inflorescence bud in organ named inflorescence http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u839i AT5G15230 ...lant Cell Physiol. 48(3):471-83. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17284469i increas

  10. Phenotype-gene: 774 [Arabidopsis Phenome Database[Archive

    Full Text Available ology in organ named obsolete microgametophyte for AT5G11110 Suzuki Toshiya et al. 2008 Oct. Plant Cell Ph... 774 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u950i abnormal for trait of morph...ysiol. 49(10):1465-77. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18779216i abnormal for trait of morph...ology in organ named obsolete microgametophyte http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u567i AT5G11110

  11. Phenotype-gene: 496 [Arabidopsis Phenome Database[Archive

    Full Text Available ward in organ named root under influence of ethene for AT1G25220 Stepanova Anna N et al. 2005 Aug. Plant Cel...luence of ethene http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u903i AT1G25220 ...l 17(8):2230-42. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15980261i insensitive toward in organ named root under inf

  12. Phenotype-gene: 498 [Arabidopsis Phenome Database[Archive

    Full Text Available ward in organ named root under influence of ethene for AT5G05730 Stepanova Anna N et al. 2005 Aug. Plant Cel...luence of ethene http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u903i AT5G05730 ...l 17(8):2230-42. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15980261i insensitive toward in organ named root under inf

  13. Phenotype-gene: 781 [Arabidopsis Phenome Database[Archive

    Full Text Available 781 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u957i abnormal for trait of morph...ology in organ named seed for AT5G18410 Li Yunhai et al. 2004 Nov. Plant Physiol. 136(3):3616-27.... http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15516496i abnormal for trait of morphology in or

  14. Phenotype-gene: 764 [Arabidopsis Phenome Database[Archive

    Full Text Available 764 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u940i abnormal for trait of morph...ology in organ named chloroplast for AT1G22700 St旦ckel Jana et al. 2006 Jul. Plant Physiol. 141(...3):870-8. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16679416i abnormal for trait of morpholo

  15. Phenotype-gene: 765 [Arabidopsis Phenome Database[Archive

    Full Text Available 765 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u941i abnormal for trait of morph...ology in organ named chloroplast for AT5G55280 Yoder David W et al. 2007 Jun. Plant Cell Physiol.... 48(6):775-91. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17468127i abnormal for trait of morph

  16. Phenotype-gene: 780 [Arabidopsis Phenome Database[Archive

    Full Text Available 780 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u956i abnormal for trait of morph...ology in organ named seed for AT2G35110 Li Yunhai et al. 2004 Nov. Plant Physiol. 136(3):3616-27.... http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15516496i abnormal for trait of morphology in or

  17. Phenotype-gene: 62 [Arabidopsis Phenome Database[Archive

    Full Text Available iency during process named unidimensional cell growth for AT3G09920 Lou Ying et al. 2007 Jan. Plant Cell 19(...1):163-81. http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17220200i decreased efficiency during process named unidimension...al cell growth http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u643i AT3G09920

  18. Reference: 371 [Arabidopsis Phenome Database[Archive

    Full Text Available 371 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u16619029i Azevedo Cr... in resistance protein accumulation in plant immunity. 9 2007-16 16619029 2006 May The EMBO journal Azevedo

  19. Reference: 478 [Arabidopsis Phenome Database[Archive

    Full Text Available 478 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17098811i Churchman ...sis thaliana. 11 3145-57 17098811 2006 Nov The Plant cell Brown Matthew L|Churchman Jason|Churchman Michelle

  20. Reference: 704 [Arabidopsis Phenome Database[Archive

    Full Text Available 704 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18069944i Wieczorek Krzysztof...al Blöchl Andreas|Bohlmann Holger|Grundler Florian M W|Hofmann Julia|Szakasits Dagmar|Wieczorek Krzysztof