WorldWideScience

Sample records for actinium 222

  1. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-08-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1- ligands (3.2+/-1.1) than AmIII (0.8+/-0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour.

  2. Separation of Actinium 227 from the uranium minerals

    International Nuclear Information System (INIS)

    The purpose of this work was to separate Actinium 227, whose content is 18%, from the mineral carnotite found in Gomez Chihuahua mountain range in Mexico. The mineral before processing is is pre-concentrated and passed, first through anionic exchange resins, later the eluate obtained is passed through cationic resins. The resins were 20-50 MESH QOWEX and 100-200 MESH 50 X 8-20 in some cased 200-400 MESH AG 50W-X8, 1X8 in other cases. The eluates from the ionic exchange were electrodeposited on stainless steel polished disc cathode and platinum electrode as anode; under a current ODF 10mA for 2.5 to 5 hours and of 100mA for .5 of an hour. it was possible to identify the Actinium 227 by means of its descendents, TH-227 and RA-223, through alpha spectroscopy. Due to the radiochemical purity which the electro deposits were obtained the Actinium 227 was low and was not quantitatively determined. A large majority of the members of the natural radioactive series 3 were identified and even alpha energies reported in the literature with very low percentages of non-identified emissions were observed. We conclude that a more precise study is needed concerning ionic exchange and electrodeposit to obtain an Actinium 227 of radiochemical purity. (Author)

  3. Spectroscopic and computational investigation of actinium coordination chemistry

    Science.gov (United States)

    Ferrier, Maryline G.; Batista, Enrique R.; Berg, John M.; Birnbaum, Eva R.; Cross, Justin N.; Engle, Jonathan W.; La Pierre, Henry S.; Kozimor, Stosh A.; Lezama Pacheco, Juan S.; Stein, Benjamin W.; Stieber, S. Chantal E.; Wilson, Justin J.

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, AcIII reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac–Cl and Ac–OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between AcIII and AmIII in HCl solutions indicate AcIII coordinates more inner-sphere Cl1– ligands (3.2±1.1) than AmIII (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique AcIII chemical behaviour. PMID:27531582

  4. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  5. Spectroscopic and computational investigation of actinium coordination chemistry.

    Science.gov (United States)

    Ferrier, Maryline G; Batista, Enrique R; Berg, John M; Birnbaum, Eva R; Cross, Justin N; Engle, Jonathan W; La Pierre, Henry S; Kozimor, Stosh A; Lezama Pacheco, Juan S; Stein, Benjamin W; Stieber, S Chantal E; Wilson, Justin J

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, Ac(III) reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between Ac(III) and Am(III) in HCl solutions indicate Ac(III) coordinates more inner-sphere Cl(1-) ligands (3.2±1.1) than Am(III) (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique Ac(III) chemical behaviour. PMID:27531582

  6. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    International Nuclear Information System (INIS)

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces ∼100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 GeV protons

  7. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  8. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    International Nuclear Information System (INIS)

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore

  9. Comment: 222 [Taxonomy Icon

    Lifescience Database Archive (English)

    Full Text Available 222.png Shinobu Okamoto (Kazusa DNA Research Institute ) licensed under CC Attribution2.1 Japan シアノバクテリア 光学顕微鏡写真 撮影:岡本忍(かずさDNA研究所) bando 2010/02/15 15:28:38 2010/02/16 10:25:09 ...

  10. MAT 222 ASH Course Tutorial / Tutorialoutlet

    OpenAIRE

    mirat

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com   MAT 222 Week 1 Solving Proportions (Ash) MAT 222 Week 1 DQ 1 Can't Cancel Terms (Ash) MAT 222 Week 2 DQ 1 One-Variable Compound Inequalities (Ash) MAT 222 Week 2 Two-Variable Inequalities (Ash) MAT 222 Week 3 DQ 1 Simplifying Radicals (Ash) MAT 222 Week 3 Real World Radical Formulas (Ash) MAT 222 Week 4 DQ 1 Solving Quadratic Equations (Ash) MAT 222 Week 4 Real World Quadratic Functions (Ash) ...

  11. 40 CFR 61.222 - Standard.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Standard. 61.222 Section 61.222... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standards for Radon Emissions From the Disposal of Uranium Mill Tailings § 61.222 Standard. (a) Radon-222 emissions to the ambient air...

  12. Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents.

    Science.gov (United States)

    Henriksen, Gjermund; Bruland, Oyvind S; Larsen, Roy H

    2004-01-01

    The present study explores the use of alpha-particle-emitting, bone-seeking agents as candidates for targeted radiotherapy. Actinium and thorium 1,4,7,10 tetraazacyclododecane N,N',N'',N''' 1,4,7,10-tetra(methylene) phosphonic acid (DOTMP) and thorium-diethylene triamine N,N',N'' penta(methylene) phosphonic acid (DTMP) were prepared and their biodistribution evaluated in conventional Balb/C mice at four hours after injection. All three bone-seeking agents showed a high uptake in bone and a low uptake in soft tissues. Among the soft tissue organs, only kidney had a relatively high uptake. The femur/kidney ratios for 227Th-DTMP, 228-Ac-DOTMP and 227Th-DOTMP were 14.2, 7.6 and 6.0, respectively. A higher liver uptake of 228Ac-DOTMP was seen than for 227Th-DTMP and 227Th-DOTMP. This suggests that some demetallation of the 228Ac-DOTMP complex had occurred. The results indicate that 225Ac-DOTMP, 227Th-DOTMP and 227Th-DTMP have promising properties as potential therapeutic bone-seeking agents.

  13. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Science.gov (United States)

    Raeder, S.; Bastin, B.; Block, M.; Creemers, P.; Delahaye, P.; Ferrer, R.; Fléchard, X.; Franchoo, S.; Ghys, L.; Gaffney, L. P.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Luton, F.; Moore, I. D.; Martinez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  14. Release of 222Rn from some soils

    Directory of Open Access Journals (Sweden)

    M. Pérez

    Full Text Available Measurements have been made of 222Rn release from diverse soils in the region surrounding Málaga, Spain. These flux measurements were carried out by two methods. A direct method using a static chamber technique and another indirect method obtained from concentration profile measurements of 222Rn in the soil air. The effects of meteorological variables and other parameters on 222Rn flux were studied. The factors that most affected the instantaneous value of 222Rn release were humidity and soil thermal gradient. The directly measured 222Rn fluxes at investigated sites are higher than 222Rn fluxes derived by the indirect method.

  15. 14 CFR 13.222 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Evidence. 13.222 Section 13.222 Aeronautics... AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.222 Evidence. (a... evidence, to submit rebuttal evidence, and to conduct any cross-examination that may be required for a...

  16. 36 CFR 222.33 - Management coordination.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Management coordination. 222.33 Section 222.33 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE RANGE MANAGEMENT Management of Wild Free-Roaming Horses and Burros § 222.33 Management coordination. All...

  17. 29 CFR 553.222 - Sleep time.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Sleep time. 553.222 Section 553.222 Labor Regulations... Enforcement Employees of Public Agencies Tour of Duty and Compensable Hours of Work Rules § 553.222 Sleep time... enforcement personnel in accordance with section 7(a)(1) of the Act, the public agency may exclude sleep...

  18. 42 CFR 93.222 - Research.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Research. 93.222 Section 93.222 Public Health... STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Definitions § 93.222 Research. Research means a systematic experiment, study,...

  19. Dicty_cDB: SSC222 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSC222 (Link to dictyBase) - - - Contig-U12265-1 SSC222E (Link... to Original site) - - - - - - SSC222E 510 Show SSC222 Library SS (Link to library) Clone ID SSC222 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSC2-A/SSC222Q.Seq.d/ Representative seq. ID SSC22...2E (Link to Original site) Representative DNA sequence >SSC222 (SSC222Q) /CSM/SS/SSC2-A/SSC222Q.Seq.d/ AACTA...SE756Q) /CSM/SS/SSE7-C/SSE756Q.Seq.d/ 688 0.0 SSC222 (SSC222Q) /CSM/SS/SSC2-A/SSC222Q.Seq.d/ 688 0.0 CHS326

  20. 33 CFR 2.22 - Territorial sea.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Territorial sea. 2.22 Section 2... Jurisdictional Terms § 2.22 Territorial sea. (a) With respect to the United States, the following apply— (1) Territorial sea means the waters, 12 nautical miles wide, adjacent to the coast of the United States...

  1. 222Rn at a Groundwater Treatment Plant

    International Nuclear Information System (INIS)

    Groundwater is a source of drinking water, usually of good quality, but compared with surface water the concentrations of radionuclides of natural origin are higher. A drinking water treatment plant for treating groundwater was monitored. The raw water is aerated, filtered through gravity sand filters and then aerated again. Radium-226 extracted from the raw water is partially retained in the filtration sand. Decay of the accumulated 226Ra generates gaseous 222Rn which is released into the treated water and into the air of the plant hall, especially during the washing of the filters. Radon-222 can pose a health risk to the operating personnel or to the public. The study evaluated the following factors: 222Ra and 226Ra concentrations in the raw and treated water, the amount of 226Ra accumulated in the filtration sand and the 222Rn concentration in the air of the plant. (author)

  2. Intercomparison of Rn-222 determination from groundwater

    DEFF Research Database (Denmark)

    Vesterbacka, P.; Pettersson, H.; Hanste, U.-M.;

    2010-01-01

    An intercomparison exercise on Rn-222 determination in groundwater was organized between eight Nordic laboratories. The individual laboratory results were in most cases within 20% of the median value and within reported uncertainties. Considering the particular difficulties in preparing, transpor......An intercomparison exercise on Rn-222 determination in groundwater was organized between eight Nordic laboratories. The individual laboratory results were in most cases within 20% of the median value and within reported uncertainties. Considering the particular difficulties in preparing...

  3. Groundwater seepage from the Ranger uranium mine tailings dam: radioisotopes of radium, thorium and actinium. Supervising Scientist report 106

    International Nuclear Information System (INIS)

    Monitoring of bores near the Ranger uranium mine tailings dam has revealed deterioration in water quality in several bores since 1983. In a group of bores to the north of the dam, increases have been observed of up to 500 times for sulphate concentrations and of up to 5 times for 226Ra concentrations. Results are presented here of measurements of members of the uranium, thorium and actinium decay series in borewater samples collected between 1985 and 1993. In particular, measurements of all four naturally-occurring radium isotopes have been used in an investigation of the mechanism of radium concentration changes. For the most seepage-affected bores the major findings of the study include: 228Ra/226Ra 223Ra /226Ra and 224Ra/228Ra ratios all increased over the course of the study; barium concentrations show high seasonal variability, being lower in November than May, but strontium concentrations show a steady increase with time. Calculations show that the groundwater is probably saturated with respect to barite but not with respect to celestite or anglesite; sulphide concentrations are low in comparison with sulphate, and are higher in November than in May; and 227Ac concentrations have increased with time, but do not account for the high 223Ra/226Ra ratios. It is concluded on the basis of these observations that increases in Ra isotope concentrations observed in a number of seepage-affected bores arise from increases in salinity leading to desorption of radium from adsorption sites in the vicinity of the bore rather by direct transport of radium from the tailings. Increased salinity is also causing the observed increases in 227Ac and strontium concentrations, while formation of a barite solid phase in the groundwater is causing the removal of some radium from solution. This is the cause of the increasing radium isotope ratios noted above

  4. 12 CFR 222.43 - Direct disputes.

    Science.gov (United States)

    2010-01-01

    ... relationship with the consumer); (v) Information related to fraud alerts or active duty alerts; or (vi... CREDIT REPORTING (REGULATION V) Duties of Furnishers of Information § 222.43 Direct disputes. (a) General... performance or other conduct concerning an account or other relationship with the furnisher, such as...

  5. 12 CFR 222.3 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... REPORTING (REGULATION V) General Provisions § 222.3 Definitions. For purposes of this part, unless...) Common ownership or common corporate control means a relationship between two companies under which: (1... both companies, a relationship described in paragraphs (i)(1)(i) through (i)(1)(iii) of this...

  6. 40 CFR 86.222-94 - Carbon monoxide analyzer calibration.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Carbon monoxide analyzer calibration. 86.222-94 Section 86.222-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.222-94 Carbon...

  7. 27 CFR 26.222 - Still wines containing carbon dioxide.

    Science.gov (United States)

    2010-04-01

    ... carbon dioxide. 26.222 Section 26.222 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... ISLANDS Formulas for Products From the Virgin Islands § 26.222 Still wines containing carbon dioxide. (a) General. Still wines may contain not more than 0.392 gram of carbon dioxide per 100 milliliters of...

  8. 20 CFR 222.35 - Relationship as stepchild.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Relationship as stepchild. 222.35 Section 222.35 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Child § 222.35 Relationship as stepchild. A claimant will be considered to...

  9. 20 CFR 222.33 - Relationship resulting from legal adoption.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Relationship resulting from legal adoption. 222.33 Section 222.33 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Child § 222.33 Relationship resulting from legal...

  10. 21 CFR 1305.17 - Preservation of DEA Forms 222.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Preservation of DEA Forms 222. 1305.17 Section 1305.17 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE ORDERS FOR SCHEDULE I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.17 Preservation of DEA Forms 222. (a) The purchaser...

  11. 48 CFR 52.222-2 - Payment for Overtime Premiums.

    Science.gov (United States)

    2010-10-01

    ... Premiums. 52.222-2 Section 52.222-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....222-2 Payment for Overtime Premiums. As prescribed in 22.103-5(b), insert the following clause: Payment for Overtime Premiums (JUL 1990) (a) The use of overtime is authorized under this contract if...

  12. Modeling the effects of exhaust ventilation on 222Rn entry rates and indoor 222Rn concentrations

    International Nuclear Information System (INIS)

    Continuous mechanical exhaust ventilation of moderately air-tight residences is common in Scandinavia and has recently been employed in several U.S. residences. Exhaust ventilation decreases the indoor pressure and, thus, increases the pressure difference which drives 222Rn entry. Relatively simple analytical (i.e. closed form) models were developed and used to examine the impacts of exhaust ventilation on 222Rn entry rates and concentrations in houses with either a crawl space or a basement. A more complex finite difference model was also developed for the house with a basement and yielded soil gas entry rates within 16% of those predicted with the analytical model. The models indicate that exhaust ventilation is suitable, but not optimal (from the perspective of indoor 222Rn), for houses with a vented crawl space. Exhaust ventilation is also indicated to be suitable for houses with basements surrounded by relatively impermeable soil (10(-12) m2 or less). If soil permeabilities are between 10(-12) and 10(-10) m2, exhaust ventilation may cause substantial increases in indoor 222Rn when soil gas 222Rn concentrations are above average. If soil permeabilities are greater than 10(-10) m2, exhaust ventilation is indicated to be inappropriate, unless some procedure is employed to inhibit soil gas entry. These conclusions should be considered tentative, since extensive verification of the models is still required

  13. Radon and the environment - 222Rn

    International Nuclear Information System (INIS)

    After having presented some physical and chemical characteristics of radon 222, this report describes the presence of radon in the environment (in the atmosphere and in soft waters), discusses the radio-toxic effect of radon on human health (exposure, epidemiology, dose calculation, share of radon in population exposure to ionizing radiations), comments the presence of radon in buildings, briefly describes actions aimed at reducing radon concentration within buildings, briefly addresses the issue of professional exposure to radon, evokes regulatory aspects (at the international level, in France, in Switzerland), and comments principles and practices of radon measurement in buildings, water, and underground cavities

  14. Use of Tricaine Methanesulfonate (MS222) for Euthanasia of Reptiles

    OpenAIRE

    Conroy, CJ; Papenfuss, T; Parker, J; Hahn, NE

    2009-01-01

    Tricaine methanesulfonate (MS222) injected into the intracoelomic cavity of reptiles was evaluated as a chemical euthanasia method. Three western fence lizards, 2 desert iguanas, 4 garter snakes, and 6 geckos were euthanized by intracoelomic injection of 250 to 500 mg/kg of 0.7% to 1% sodium-bicarbonate–buffered MS222 solution followed by intracoelomic injection of 0.1 to 1.0 ml unbuffered 50% (v/v) MS222 solution. A simple 2-stage protocol for euthanasia of reptiles by using MS222 is outline...

  15. 40 CFR 222.12 - Appeal to Administrator.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Appeal to Administrator. 222.12... ON OCEAN DUMPING PERMIT APPLICATIONS UNDER SECTION 102 OF THE ACT § 222.12 Appeal to Administrator. (a)(1) The Administrator delegates to the Environmental Appeals Board authority to issue...

  16. 49 CFR Appendix F to Part 222 - Diagnostic Team Considerations

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Diagnostic Team Considerations F Appendix F to.... 222, App. F Appendix F to Part 222—Diagnostic Team Considerations For purposes of this part, a diagnostic team is a group of knowledgeable representatives of parties of interest in a highway-rail...

  17. 12 CFR 222.24 - Reasonable opportunity to opt out.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Reasonable opportunity to opt out. 222.24 Section 222.24 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... consumers to write a “yes” or “no” to indicate their opt-out preference or that requires the consumer...

  18. 36 CFR 222.2 - Management of the range environment.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Management of the range environment. 222.2 Section 222.2 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE... environment. (a) Allotments will be designated on the National Forest System and on other lands under...

  19. 20 CFR 222.32 - Relationship as a natural child.

    Science.gov (United States)

    2010-04-01

    ... FAMILY RELATIONSHIPS Relationship as Child § 222.32 Relationship as a natural child. A claimant will be... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Relationship as a natural child. 222.32... first day of the month in which it actually occurred. (d) Other evidence of relationship. The...

  20. 7 CFR 1280.222 - Books and Records of Board.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Books and Records of Board. 1280.222 Section 1280.222 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE LAMB PROMOTION, RESEARCH,...

  1. 40 CFR 60.222 - Standard for fluorides.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Standard for fluorides. 60.222 Section... Industry: Diammonium Phosphate Plants § 60.222 Standard for fluorides. (a) On and after the date on which... facility any gases which contain total fluorides in excess of 30 g/megagram (Mg) of equivalent P2O5 feed...

  2. 20 CFR 222.12 - Ceremonial marriage relationship.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Ceremonial marriage relationship. 222.12... FAMILY RELATIONSHIPS Relationship as Wife, Husband, or Widow(er) § 222.12 Ceremonial marriage relationship. A valid ceremonial marriage is one which would be recognized as valid by the courts of the...

  3. 20 CFR 222.13 - Common-law marriage relationship.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Common-law marriage relationship. 222.13... FAMILY RELATIONSHIPS Relationship as Wife, Husband, or Widow(er) § 222.13 Common-law marriage relationship. Under the laws of some States, a common-law marriage is one which is not solemnized in a...

  4. 20 CFR 222.14 - Deemed marriage relationship.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Deemed marriage relationship. 222.14 Section... FAMILY RELATIONSHIPS Relationship as Wife, Husband, or Widow(er) § 222.14 Deemed marriage relationship. If a ceremonial or common-law marriage relationship cannot be established under State law, a...

  5. 40 CFR 222.3 - Notice of applications.

    Science.gov (United States)

    2010-07-01

    ... 222.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING ACTION ON OCEAN DUMPING PERMIT APPLICATIONS UNDER SECTION 102 OF THE ACT § 222.3 Notice of applications. (a...; (ii) That the emergency poses an unacceptable risk relating to human health; (iii) That the...

  6. 42 CFR 457.222 - FFP for equipment.

    Science.gov (United States)

    2010-10-01

    ... participation in the cost of equipment under CHIP are determined in accordance with subpart G of 45 CFR part 95... of 45 CFR part 95. ... 42 Public Health 4 2010-10-01 2010-10-01 false FFP for equipment. 457.222 Section 457.222...

  7. 5 CFR 9901.222 - Review of classification decisions.

    Science.gov (United States)

    2010-01-01

    ... either DoD or OPM the issues designated as nonappealable to the Office of Personnel Management in 5 CFR....222 Section 9901.222 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF...

  8. 36 CFR 222.29 - Relocation and disposal of animals.

    Science.gov (United States)

    2010-07-01

    ... animals. 222.29 Section 222.29 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... disposal of animals. (a) The Chief, Forest Service, shall, when he determines over-population of wild... animals from that particular territory. Such action shall be taken until all excess animals have...

  9. 40 CFR 22.2 - Use of number and gender.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Use of number and gender. 22.2 Section... PERMITS General § 22.2 Use of number and gender. As used in these Consolidated Rules of Practice, words in the singular also include the plural and words in the masculine gender also include the feminine,...

  10. 33 CFR 222.4 - Reporting earthquake effects.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Reporting earthquake effects. 222..., DEPARTMENT OF DEFENSE ENGINEERING AND DESIGN § 222.4 Reporting earthquake effects. (a) Purpose. This... significant earthquakes. It primarily concerns damage surveys following the occurrences of earthquakes....

  11. 48 CFR 222.406-6 - Payrolls and statements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Payrolls and statements... Labor Standards for Contracts Involving Construction 222.406-6 Payrolls and statements. (a) Submission..., Statement of Compliance, with each payroll report....

  12. 48 CFR 252.222-7005 - Prohibition on use of nonimmigrant aliens-Guam.

    Science.gov (United States)

    2010-10-01

    ... nonimmigrant aliens-Guam. 252.222-7005 Section 252.222-7005 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.222-7005 Prohibition on use of nonimmigrant aliens—Guam. As prescribed in 222.7302, use the following clause: Prohibition on Use of Nonimmigrant Aliens—Guam (SEP...

  13. Acute Exposure from RADON-222 and Aerosols in Drinking Water

    Science.gov (United States)

    Bernhardt, George Paul, IV

    Radon-222 in water is released when the water is aerated, such as during showering. As a result, a temporary burst of radon-222 can appear as a short term, or acute, exposure. This study looked at homes with radon-222 concentrations in water from 800 picocuries per liter (pCi/l) to 53,000 pCi/l to determine the buildup of radon gas in a bathroom during showering. Samples from the tap and drain, compared to determine the percentage of radon-222 released, showed that between 58% and 88% of radon-222 in the water was released. The resultant radon-222 increase in air, measured with a flow-through detector, ranged from 2 pCi/l to 114 pCi/l in bathrooms due to a 10 to 15 minute shower with water flow rates ranging from 3 l/min to 6 l/min. Significantly, these rates did not fall rapidly but stayed approximately the same for up to 15 minutes after the water flow ceased. In examining exposures, the true danger is in the radon-222 progeny rather than the radon itself. The progeny can be inhaled and deposited in the tracheobronchial passages in the lung. Filter samples of bathroom air measured in a portable alpha spectrometer showed an increase in radon-222 progeny, notably polonium-218 and -214, in the air after showering. These increases were gradual and were on the order of 0.5 pCi/l at the highest level. Tap samples measured in a portable liquid scintillator showed that the progeny are present in the water but are not in true secular equilibrium with the radon-222 in the water. Therefore, the radon-222 does not have to decay to produce progeny since the progeny are already present in the water. A two stage sampler was used to examine the percentage of radiation available in aerosols smaller than 7 microns. Repeated trials showed that up to 85% of the radiation available in the aerosols is contained in the smaller, more respirable particles.

  14. Indoor 222Rn survey in Zacatecas State, Mexico

    International Nuclear Information System (INIS)

    As part of a program for discovering whether afflicted areas exist, indoor 222Rn concentrations in the State of Zacatecas were surveyed, 222Rn concentration being measured by γ-ray spectrometry of radon decay products adsorbed into charcoal canisters. A survey was implemented during Summer 2001: 228 dwellings in the state were tested by taking mean 254 measurements. Concentrations exhibited a left-skewed distribution of indoor 222Rn, showing overall average, minimum, and maximum concentrations of 67, 26, and 511 Bq m-3, respectively. Only seven of the measurements (2.7%) were found equal to or greater than the US EPA action limit (148 Bq m-3). Thus, we conclude that the indoor radon environment in Zacatecas State is under US EPA action limit. The few high concentration spots suggest that geological conditions rather than construction materials may be the determinant factor

  15. Measurements of octupole collectivity in $^{220,222}$Rn and $^{222,224}$Ra using Coulomb excitation

    CERN Multimedia

    Kruecken, R; Larsen, A; Hurst, A M; Voulot, D; Grahn, T; Clement, E; Wadsworth, R; Gernhaeuser, R A; Siem, S; Huyse, M L; Iwanicki, J S

    2008-01-01

    We propose to exploit the unique capability of ISOLDE to provide post-accelerated $^{220,222}$Rn and $^{222,224}$Ra ion beams from the REX facility to enable the Coulomb excitation of the first 3$^{-}$ states in these nuclei. By measuring the $\\gamma$-ray yields of the E1 decays from the 3$^{-}$ state using the MINIBALL array we can obtain the transition matrix elements. This will give quantitative information about octupole correlations in these nuclei. We require 22 shifts to fulfil the aims of the experiment.

  16. 40 CFR 98.222 - GHGs to report.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Nitric Acid Production § 98.222 GHGs to report. (a) You must report N2O process emissions from each nitric acid production train as required by this subpart. (b) You must report...

  17. 20 CFR 222.34 - Relationship resulting from equitable adoption.

    Science.gov (United States)

    2010-04-01

    ... RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Child § 222.34 Relationship resulting from... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Relationship resulting from equitable... adopted child. A claimant will have the relationship of an equitably adopted child for annuity and...

  18. 20 CFR 222.36 - Relationship as grandchild or stepgrandchild.

    Science.gov (United States)

    2010-04-01

    ... RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Child § 222.36 Relationship as grandchild or stepgrandchild. A claimant will have the relationship of grandchild or stepgrandchild of an employee, or the... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Relationship as grandchild or...

  19. 20 CFR 222.11 - Determination of marriage relationship.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Determination of marriage relationship. 222... marriage relationship. A claimant will be considered to be the husband, wife, or widow(er) of an employee... claimant and employee were validly married, or if a deemed marriage is established. (a) Generally,...

  20. 48 CFR 1652.222-70 - Notice of significant events.

    Science.gov (United States)

    2010-10-01

    ... statements. (b) Upon learning of a Significant Event OPM may institute action, in proportion to the... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Notice of significant... of FEHBP Clauses 1652.222-70 Notice of significant events. As prescribed in 1622.103-70,...

  1. 48 CFR 222.403-4 - Department of Labor regulations.

    Science.gov (United States)

    2010-10-01

    ... ACQUISITIONS Labor Standards for Contracts Involving Construction 222.403-4 Department of Labor regulations. Direct all questions regarding Department of Labor regulations to the labor advisor. ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Department of...

  2. 40 CFR 180.222 - Prometryn; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Prometryn; tolerances for residues...) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.222 Prometryn; tolerances for residues. (a) General. Tolerances are established for residues...

  3. 48 CFR 352.222-70 - Contractor cooperation in equal employment opportunity investigations.

    Science.gov (United States)

    2010-10-01

    ... Opportunity (EEO) complaints processed pursuant to 29 CFR Part 1614. For purposes of this clause, the... equal employment opportunity investigations. 352.222-70 Section 352.222-70 Federal Acquisition... Texts of Provisions and Clauses 352.222-70 Contractor cooperation in equal employment...

  4. 48 CFR 252.222-7006 - Restrictions on the Use of Mandatory Arbitration Agreements.

    Science.gov (United States)

    2010-10-01

    ... Mandatory Arbitration Agreements. 252.222-7006 Section 252.222-7006 Federal Acquisition Regulations System... Arbitration Agreements. As prescribed in 222.7404, use the following clause: Restrictions on the Use of Mandatory Arbitration Agreements (MAY 2010) (a) Definitions. As used in this clause— Covered...

  5. 36 CFR 222.51 - National Forests in 16 Western States.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false National Forests in 16 Western States. 222.51 Section 222.51 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE RANGE MANAGEMENT Grazing Fees § 222.51 National Forests in 16 Western States. (a) Grazing fees...

  6. 78 FR 61446 - Fourteenth Meeting: RTCA Special Committee 222, Inmarsat AMS(R)S

    Science.gov (United States)

    2013-10-03

    ... Federal Aviation Administration Fourteenth Meeting: RTCA Special Committee 222, Inmarsat AMS(R)S AGENCY... RTCA Special Committee 222, Inmarsat AMS(R)S. SUMMARY: The FAA is issuing this notice to advise the public of the fourteenth meeting of the RTCA Special Committee 222, Inmarsat AMS(R)S DATES: The...

  7. 78 FR 8684 - Twelfth Meeting: RTCA Special Committee 222, Inmarsat AMS(R)S

    Science.gov (United States)

    2013-02-06

    ... Federal Aviation Administration Twelfth Meeting: RTCA Special Committee 222, Inmarsat AMS(R)S AGENCY... RTCA Special Committee 222, Inmarsat AMS(R)S. SUMMARY: The FAA is issuing this notice to advise the public of the twelfth meeting of the RTCA Special Committee 222, Inmarsat AMS(R)S. DATES: The...

  8. 50 CFR 222.305 - Rights of succession and transfer of permits.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Rights of succession and transfer of permits. 222.305 Section 222.305 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL... THREATENED MARINE SPECIES General Permit Procedures § 222.305 Rights of succession and transfer of...

  9. 48 CFR 252.222-7004 - Compliance with Spanish social security laws and regulations.

    Science.gov (United States)

    2010-10-01

    ... Condition of the Enterprise) from the Ministerio de Trabajo y S.S., Tesoreria General de la Seguridad Social... social security laws and regulations. 252.222-7004 Section 252.222-7004 Federal Acquisition Regulations... PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.222-7004 Compliance with Spanish...

  10. Instruments to measure radon-222 activity concentration or exposure to radon-222. Intercomparison 2014

    International Nuclear Information System (INIS)

    According to the Directive 96/29/EURATOM the monitoring of occupational radiation exposures shall base on individual measurements carried out by an approved dosimetric service. Pursuant to the European Directive an approved dosimetric service is a body responsible for the calibration, reading or interpretation of individual monitoring devices.., whose capacity to act in this respect is recognized by the competent authorities. This concept will also be applied to radon services issuing passive radon measurement devices. Passive radon measurement devices1 using solid state nuclear track detectors or electrets are recommended for individual monitoring of exposures to radon. German regulations lay down that radon measuring devices are appropriate for purposes of occupational radiation monitoring if the devices are issued by recognized radon measurement services, and the measurement service submits devices of the same type issued for radon monitoring to regular intercomparisons conducted by the Bundesamt fuer Strahlenschutz (BfS). A radon measuring service is recognized by the competent authority if it proves its organisational and technical competence, e. g. by accreditation. These regulations have been introduced in the area of occupational radiation exposures. Nevertheless, it is recommended that radon measuring services which carry out radon measurements in other areas (e.g. dwellings) should subject themselves to these measures voluntarily. The interlaboratory comparisons comprise the organization, exposure, and evaluation of measurements of radon activity concentration or exposure to radon. The comparisons only concern radon-222; radon-220 is not in the scope. Radon services being interested can get further information from the European Information System on Proficiency Testing Schemes (EPTIS) and from the BfS websites.

  11. The Dark Matter filament between Abell 222/223

    Science.gov (United States)

    Dietrich, Jörg P.; Werner, Norbert; Clowe, Douglas; Finoguenov, Alexis; Kitching, Tom; Miller, Lance; Simionescu, Aurora

    2016-10-01

    Weak lensing detections and measurements of filaments have been elusive for a long time. The reason is that the low density contrast of filaments generally pushes the weak lensing signal to unobservably low scales. To nevertheless map the dark matter in filaments exquisite data and unusual systems are necessary. SuprimeCam observations of the supercluster system Abell 222/223 provided the required combination of excellent seeing images and a fortuitous alignment of the filament with the line-of-sight. This boosted the lensing signal to a detectable level and led to the first weak lensing mass measurement of a large-scale structure filament. The filament connecting Abell 222 and Abell 223 is now the only one traced by the galaxy distribution, dark matter, and X-ray emission from the hottest phase of the warm-hot intergalactic medium. The combination of these data allows us to put the first constraints on the hot gas fraction in filaments.

  12. Low background counting of 222Rn, 220Rn and 219Rn with electrostatic counters

    Science.gov (United States)

    Mong, Brian; EXO-200 Collaboration; nEXO Collaboration

    2014-09-01

    The radon counting technique based on electrostatic precipitation of progenies in gas followed by alpha spectroscopy has been applied to support the material selection programs of low background, neutrino and dark matter experiments with emphasis on EXO. An array of 8 counters operated by Laurentian University at SNOLAB and the Waste Isolation Pilot Plant have reached the sensitivity of 10 atoms/day in the uranium, thorium and actinium chains. Hardware improvements are underway to further increase the capacity and sensitivity in support of nEXO. The radon counting technique based on electrostatic precipitation of progenies in gas followed by alpha spectroscopy has been applied to support the material selection programs of low background, neutrino and dark matter experiments with emphasis on EXO. An array of 8 counters operated by Laurentian University at SNOLAB and the Waste Isolation Pilot Plant have reached the sensitivity of 10 atoms/day in the uranium, thorium and actinium chains. Hardware improvements are underway to further increase the capacity and sensitivity in support of nEXO. Supported by NSERC Project Grants ``Search for Double Beta Decay with EXO.''

  13. Using 222 Rn for hydrograph separationin a micro basin (Luxembourg)

    OpenAIRE

    Hoffmann, L.; Tosheva, Z.; Hofmann, H.; Kies, A.; Pfister, L.

    2005-01-01

    In order to obtain information on the hydrological signature of rivers during and after heavy rain events, small catchment areas are selected as experimental sites. Hydrograph separations based on environmental tracers are performed. Natural isotopic tracers such as 18O, 2H and particularly 222Rn may help to distinguish the components dominating the outflow, particularly of 'pre-event waters', 'event waters' and 'post-event waters'. Even with moderate concentrations in gro...

  14. Hanford Facility Dangerous Waste Permit Application, 222-S Laboratory Complex

    International Nuclear Information System (INIS)

    The Hanford Facility Dangerous Waste Permit Application is considered to be a single application organized into a General Information Portion (document number DOE/RL-91-28) and a Unit-Specific Portion. The scope of the Unit-Specific Portion is limited to Part B permit application documentation submitted for individual, operating treatment, storage, and/or disposal units, such as the 222-S Laboratory Complex (this document, DOE/RL-91-27). Both the General Information and Unit-Specific portions of the Hanford Facility Dangerous Waste Permit Application address the content of the Part B permit application guidance prepared by the Washington State Department of Ecology (Ecology 1987 and 1996) and the U.S. Environmental Protection Agency (40 Code of Federal Regulations 270), with additional information needs defined by the Hazardous and Solid Waste Amendments and revisions of Washington Administrative Code 173-303. For ease of reference, the Washington State Department of Ecology alpha-numeric section identifiers from the permit application guidance documentation (Ecology 1996) follow, in brackets, the chapter headings and subheadings. Documentation contained in the General Information Portion is broader in nature and could be used by multiple treatment, storage, and/or disposal units (e.g., the glossary provided in the General Information Portion). Wherever appropriate, the 222-S Laboratory Complex permit application documentation makes cross-reference to the General Information Portion, rather than duplicating text. Information provided in this 222-S Laboratory Complex permit application documentation is current as of August 2000

  15. Calibration of radon-222 detectors using closed circuit radium-226 sources; Calibracao de detectores de radonio-222 atraves do uso de fontes de radio-222 em circuito fechado

    Energy Technology Data Exchange (ETDEWEB)

    Perna, Allan Felipe Nunes; Paschuk, Sergei Anatolyevich; Correa, Janine Nicolosi; Del Claro, Flavia, E-mail: allan_perna@hotmail.com, E-mail: sergei@utfpr.edu.br, E-mail: janine@utfpr.edu.br, E-mail: flavia_delclaro@yahoo.com.br [Universidade Tecnologica Federal do Parana (UTFPR), Curitiba, PR (Brazil)

    2012-07-01

    This paper presents the results of the calibration of the Radon-222 detectors used by the Laboratories specializing in measuring natural radiation from this gas. The research was conducted in collaboration between UTFPR, CDTN/CNEN, UFRN and IRD/CNEN. During the calibration the detectors were exposed in isolated chambers with radioactive calibrated sources. The calibration procedure was supported with four instant radon monitors AlphaGUARD (SAPHYMO Co.) responsible for radon activity measurements in the experimental chamber. The calibration procedure resulted an equation that relates the number of tracks found in solid-state detector CR-39 (Track-Etch detector) with the concentration of radon in the atmosphere. Obtained results are compatible with previously performed calibration at the National Institute of Radiological Sciences (NIRS, Japan) using high activity levels of radon in air. Present results of calibration give the possibility to expand the calibration curve of CR-39 for medium and low activity levels of radon. (author)

  16. 22 CFR 40.68 - Aliens subject to INA 222(g).

    Science.gov (United States)

    2010-04-01

    ... new nonimmigrant visa unless the alien complies with the requirements in 22 CFR 41.101 (b) or (c... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Aliens subject to INA 222(g). 40.68 Section 40... § 40.68 Aliens subject to INA 222(g). An alien who, under the provisions of INA 222(g), has voided...

  17. Tracing and quantifying groundwater inflow into lakes using radon-222

    Directory of Open Access Journals (Sweden)

    T. Kluge

    2007-06-01

    Full Text Available Due to its high activities in groundwater, the radionuclide 222Rn is a sensitive natural tracer to detect and quantify groundwater inflow into lakes, provided the comparatively low activities in the lakes can be measured accurately. Here we present a simple method for radon measurements in the low-level range down to 3 Bq m−3, appropriate for groundwater-influenced lakes, together with a concept to derive inflow rates from the radon budget in lakes. The analytical method is based on a commercially available radon detector and combines the advantages of established procedures with regard to efficient sampling and sensitive analysis. Large volume (12 l water samples are taken in the field and analyzed in the laboratory by equilibration with a closed air loop and alpha spectrometry of radon in the gas phase. After successful laboratory tests, the method has been applied to a small dredging lake without surface in- or outflow in order to estimate the groundwater contribution to the hydrological budget. The inflow rate calculated from a 222Rn balance for the lake is around 530 m3 per day, which is comparable to the results of previous studies. In addition to the inflow rate, the vertical and horizontal radon distribution in the lake provides information on the spatial distribution of groundwater inflow to the lake. The simple measurement and sampling technique encourages further use of radon to examine groundwater-lake interaction.

  18. Factors controlling temporal variability of near-ground atmospheric 222Rn concentration over Central Europe

    Directory of Open Access Journals (Sweden)

    M. Zimnoch

    2014-02-01

    222Rn content in Krakow was approximately 30 % higher when compared to Heidelberg (5.86 ± 0.09 Bq −3 and 4.50 ± 0.07 Bq m−3, respectively. Distinct seasonality of 222Rn signal was visible in both presented time series, with higher values recorded generally during late summer and autumn. The surface 222Rn fluxes in Krakow also revealed a distinct seasonality, with broad maximum observed during summer and early autumn and minimum during the winter. Averaged over 5 yr observation period, the night-time surface 222Rn flux was equal 46.8 ± 2.4 Bq m−2 h−1. Although the atmospheric 222Rn levels at Heidelberg and Krakow appeared to be controlled primarily by local factors, it was possible to evaluate the "continental effect" in atmospheric 222Rn content between both sites, related to the gradual build-up of 222Rn concentration in the air masses travelling between Heidelberg and Krakow. The mean value of this load was equal 0.78 ± 0.12 Bq m−3. The measured minimum 222Rn concentrations at both sites and the difference between them was interpreted in the framework of a simple box model coupled with HYSPLIT analysis of air mass trajectories. Best fit of experimental and model data was obtained for the average 222Rn flux over the European continent equal 52 Bq m−2 h−1, the mean transport velocity of the air masses within convective mixed layer of PBL on their route from the Atlantic coast to Heidelberg and Krakow equal 3.5 m s−1, the mean rate constant of 222Rn removal across the top of PBL equal to the 222Rn decay constant and the mean height of the convective mixed layer height equal 1600 m.

  19. D2.2.2 Final Version of the LinkedUp Evaluation Framework

    NARCIS (Netherlands)

    Drachsler, Hendrik; Stoyanov, Slavi; Guy, Marieke; Scheffel, Maren

    2014-01-01

    This document (D2.2.2) describes the LinkedUp consortium’s experience in developing and on- going improvement of the LinkedUp Evaluation Framework throughout three web open educational data competitions: Veni, Vidi, Vici. D2.2.2 is the final report regarding the Evaluation Framework (EF). It synthes

  20. 12 CFR 222.90 - Duties regarding the detection, prevention, and mitigation of identity theft.

    Science.gov (United States)

    2010-01-01

    ... CFR 603.2(a). (9) Red Flag means a pattern, practice, or specific activity that indicates the possible... mitigation of identity theft. 222.90 Section 222.90 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM FAIR CREDIT REPORTING (REGULATION V) Identity Theft...

  1. 48 CFR 222.7301 - Prohibition on use of nonimmigrant aliens.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Prohibition on use of nonimmigrant aliens. 222.7301 Section 222.7301 Federal Acquisition Regulations System DEFENSE ACQUISITION... aliens. (a) Any alien who is issued a visa or otherwise provided nonimmigrant status under Section...

  2. 48 CFR 2452.222-70 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Accessibility of meetings, conferences, and seminars to persons with disabilities. 2452.222-70 Section 2452.222-70 Federal Acquisition... (e.g., sign language interpreters) for each meeting, conference, or seminar in light of the known...

  3. 12 CFR Appendix J to Part 222 - Interagency Guidelines on Identity Theft Detection, Prevention, and Mitigation

    Science.gov (United States)

    2010-01-01

    ... Program rules implementing 31 U.S.C. 5318(l) (31 CFR 103.121); and (b) Authenticating customers... Detection, Prevention, and Mitigation J Appendix J to Part 222 Banks and Banking FEDERAL RESERVE SYSTEM..., App. J Appendix J to Part 222—Interagency Guidelines on Identity Theft Detection, Prevention,...

  4. 48 CFR 252.222-7003 - Permit from Italian Inspectorate of Labor.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Permit from Italian... CLAUSES Text of Provisions And Clauses 252.222-7003 Permit from Italian Inspectorate of Labor. As prescribed in 222.7201(b), use the following clause: Permit from Italian Inspectorate of Labor (JUN...

  5. 33 CFR 222.3 - Clearances for power and communication lines over reservoirs.

    Science.gov (United States)

    2010-07-01

    ... be provided when relocating existing or constructing new power and communication lines over waters of... section). (e) Required clearances. Minimum vertical clearances for power and communication lines over... communication lines over reservoirs. 222.3 Section 222.3 Navigation and Navigable Waters CORPS OF...

  6. 36 CFR 222.53 - Grazing fees in the East-noncompetitive procedures.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Grazing fees in the East-noncompetitive procedures. 222.53 Section 222.53 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT... respond to significant changes in the agricultural economy in the East, and to ensure that fees...

  7. Nationwide indoor {sup 222}Rn and {sup 220}Rn map for India: a review

    Energy Technology Data Exchange (ETDEWEB)

    Ramachandan, T.V. [Ex-Environmental Assessment Division, Bhabha Atomic Research Center, Mumbai-450 085 (India); Sathish, L.A., E-mail: lasgayit@yahoo.com [Post Graduate Department of Physics, Government Science College, Nrupathunga Road, Bangalore 560 001 (India)

    2011-11-15

    Considering the role of radon in epidemiology, an attempt was made to make a nation-wide map of indoor {sup 222}Rn and {sup 220}Rn for India. More than 5000 measurements have been carried out in 1500 dwellings across the country comprising urban and nonurban locations. The solid state nuclear track detectors based twin cup {sup 222}Rn/{sup 220}Rn discrimination dosimeters were deployed for the measurement of indoor {sup 222}Rn, {sup 220}Rn and their progeny levels. The geometric means of estimated annual inhalation dose rate due to indoor {sup 222}Rn, {sup 220}Rn and their progeny in the dwellings was 0.94 mSvy{sup -1} (geometric standard deviation 2.5). It was observed that the major contribution to the indoor inhalation dose was due to indoor {sup 222}Rn and its progeny. However, the contribution due to indoor {sup 220}Rn and its progeny was not trivial as it was found to be about 20% of the total indoor inhalation dose rates. The indoor {sup 222}Rn levels in dwellings was significantly different depending on the nature of walls and floorings. - Highlights: > A countrywide survey on {sup 222}Rn and {sup 220}Rn levels for India was carried out in dwellings. > The regional values are obtained from the data on a few houses in that area. > Calibration factors for the measurements were derived experimentally as well as theoretically. > The {sup 222}Rn and {sup 220}Rn levels are represented on the maps.

  8. 12 CFR 222.21 - Affiliate marketing opt-out and exceptions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Affiliate marketing opt-out and exceptions. 222.21 Section 222.21 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE... solicitations to the consumer about homeowner's insurance. (ii) A consumer completes an online application...

  9. A simple and versatile {sup 222}Rn/{sup 220}Rn exposure chamber

    Energy Technology Data Exchange (ETDEWEB)

    Yu, K.N. E-mail: peter.yu@cityu.edu.hk; Koo, V.S.Y.; Guan, Z.J

    2002-04-01

    A simple {sup 222}Rn/{sup 220}Rn exposure chamber is described. The chamber is made of acrylic and has a volume of 0.41 m{sup 3}. The {sup 222}Rn and {sup 220}Rn sources can be operated independently or simultaneously. The concentrations of {sup 222}Rn and {sup 220}Rn were monitored by a continuous alpha spectrometer called RAD7. The capability of alpha spectrometry has removed the mutual interference between {sup 220}Rn and {sup 222}Rn, which is a major problem in measuring {sup 220}Rn. Furthermore, the capability can also provide fast response to changes in the {sup 222}Rn level and {sup 220}Rn level in the exposure chamber, with temporal resolutions of about 20 and 2 min, respectively.

  10. Antimicrobial, antioxidant, cytotoxic and molecular docking properties of N-benzyl-2,2,2-trifluoroacetamide

    Science.gov (United States)

    Balachandran, C.; Kumar, P. Saravana; Arun, Y.; Duraipandiyan, V.; Sundaram, R. Lakshmi; Vijayakumar, A.; Balakrishna, K.; Ignacimuthu, S.; Al-Dhabi, N. A.; Perumal, P. T.

    2015-02-01

    N-Benzyl-2,2,2-trifluoroacetamide was obtained by acylation of benzylamine with trifluoroacetic anhydride using Friedel-Crafts acylation method. The synthesised compound was confirmed by spectroscopic and crystallographic techniques. N-Benzyl-2,2,2 -trifluoroacetamide was assessed for its antimicrobial, antioxidant, cytotoxic and molecular docking properties. It showed good antifungal activity against tested fungi and moderate antibacterial activity. The minimum inhibitory concentration values of N-benzyl-2,2,2 -trifluoroacetamide against fungi were 15.62 μg/mL against A. flavus, 31.25 μg/mL against B. Cinerea and 62.5 μg/mL against T. mentagrophytes, Scopulariopsis sp., C. albicans and M. pachydermatis. N-Benzyl-2,2,2-trifluoroacetamide showed 78.97 ± 2.24 of antioxidant activity at 1,000 μg/mL. Cupric ion reducing antioxidant capacity of N-benzyl-2,2,2-trifluoroacetamide was dependent on the concentration. Ferric reducing antioxidant power assay of N-benzyl-2,2,2-trifluoroacetamide showed (1.352 ± 0.04 mM Fe(II)/g) twofold higher value compared to the standard. N-Benzyl-2,2,2-trifluoroacetamide showed 75.3 % cytotoxic activity at the dose of 200 μg/mL with IC50 (54.7 %) value of 100 μg/mL. N-Benzyl-2,2,2-trifluoroacetamide was subjected to molecular docking studies for the inhibition AmpC beta-lactamase, Glucosamine-6-Phosphate Synthase and lanosterol 14 alpha-demethylase (CYP51) enzymes which are targets for antibacterial and antifungal drugs. Docking studies of N-benzyl-2,2,2-trifluoroacetamide showed low docking energy. N-Benzyl-2,2,2-trifluoroacetamide can be evaluated further for drug development.

  11. 222Rn + 220Rn monitoring by alpha spectrometry

    International Nuclear Information System (INIS)

    Controlled 222Rn + 220Rn mixed atmospheres have been realised introducing calibrated sources in a stainless steel chamber. An electrostatic alpha monitor internal to the chamber has been used for an accurate discrimination of alpha peaks due to the products of the two isotopes. In the chamber, different specific activities are achieved in order to test the response of the internal reference instrument and to evaluate the possible interferences due to contemporary presence of both radon isotopes. Results show that: (i) the atmospheres are very stable, (ii) the monitor is adequate for their control because the various alpha lines are well evaluated and (iii) using TyvekR filter, the efficiency of monitor is stable and constant vs. activity. (authors)

  12. Ambient Radon-222 Monitoring in Amargosa Valley, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    L.H. Karr; J.J. Tappen; D. Shafer; K.J. Gray

    2008-06-05

    As part of a program to characterize and baseline selected environmental parameters in the region around the proposed repository at Yucca Mountain, Nevada, ambient radon-222 monitoring was conducted in the rural community of Amargosa Valley, the community closest to the proposed repository site. Passive integrating radon monitors and a continuous radon monitoring instrument were deployed adjacent to the Community Environmental Monitoring Program (CEMP) (http://www.cemp.dri.edu/index.html) station located in the Amargosa Valley Community Center near the library. The CEMP station provided real-time ambient gamma exposure and meteorological data used to correct the integrated radon measurements as well as verify meteorological data collected by the continuous radon monitoring instrument. Additionally, different types of environmental enclosures that housed the monitors and instrument were used to determine if particular designs influenced the ambient radon measurements.

  13. Radon-222 measurement in a uranium prospecting area in Brazil

    International Nuclear Information System (INIS)

    Rn-222 concentrations were determined in about 100 measuring points in an uranium prospecting area in the eastern part of Brazil. The single measurement results in open areas, identified as environmental points, present values between 4 ± 2 Bq/m-3 and 404 ± 16 Bq/m-3 with a mean value of 62 ± 10 Bq/m-3. Comparing the mean values for each measuring point, the values obtained are between 15 ± 2 Bq/m-3 in the deposit for mineral samples and 245 ±7 Bq/m-3 for the central point, AN08, of the prospective mine. Makrofol SSNTD were used for the measurements and exposed for 120 days alternated periods from May 1992 to May 1994. (authors). 8 refs., 1 tab

  14. 222Rn and decay products in outdoor and indoor environments

    International Nuclear Information System (INIS)

    Radon-222 (radon) and radon daughter (RnD) measurement methodologies are analysed from both theoretical and experimental points of view. It is shown that exhalation from enclosed porous materials can be described in terms of the time-dependent diffusion theory. Deficiencies in the established accumulator method of radon exhalation measurement are shown. By the existing methods, the true free exhalation rate of thin samples may be underestimated by a factor of (1+α-1), in radon-tight accumulators (α is the outer to inner volume ratio of the sample). The term back-diffusion is clarified and shown applicable to steady-state conditions only. The wire-screen technique is utilized to separate aerosol-attached and unattached RnD in a 3 m3 radon cell. The effect of air-filtration on the RnDs is expressed as individual activity concentrations as well as in terms of effective dose equivalent rate, H. H has been reduced by a factor between 1.3 and 2.5 for the small-sized areosol particles used (surface area median less than 100 nm), at the filtration rate constant 5 h-1. The exact reduction value is dependent on initial aerosol load, type of filter, and dose model (Jacobi-Eisfeld and James-Birchall in this investigation). The concentration of radon and Pb-210 in the Arctic summer air averaged 75+-21 and 0.075+-0.028 mBq m-3, during the Swedish Ymer-80 expedition. It is shown that steadystate equilibrium models are unsuitable for estimation of the mean aerosol residence time in ocean air. A good qualitative agreement between radon-levels and the time since the air mass left larger land areas was found. The radon-222 and long-lived daughter (Pb-210, Po-210) measurements are insensitive to ship- and local contaminations. (author)

  15. 36 CFR 222.21 - Administration of wild free-roaming horses and burros and their environment.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Administration of wild free-roaming horses and burros and their environment. 222.21 Section 222.21 Parks, Forests, and Public Property... Burros § 222.21 Administration of wild free-roaming horses and burros and their environment. (a)...

  16. 49 CFR Appendix G to Part 222 - Excess Risk Estimates for Public Highway-Rail Grade Crossings

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Excess Risk Estimates for Public Highway-Rail Grade Crossings G Appendix G to Part 222 Transportation Other Regulations Relating to Transportation... HIGHWAY-RAIL GRADE CROSSINGS Pt. 222, App. G Appendix G to Part 222—Excess Risk Estimates for...

  17. 36 CFR 222.26 - Removal of wild free-roaming horses and burros from private lands.

    Science.gov (United States)

    2010-07-01

    ... horses and burros from private lands. 222.26 Section 222.26 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE RANGE MANAGEMENT Management of Wild Free-Roaming Horses and Burros § 222.26 Removal of wild free-roaming horses and burros from private lands. Owners of land upon...

  18. 36 CFR 222.27 - Maintenance of wild free-roaming horses and burros on privately-owned lands.

    Science.gov (United States)

    2010-07-01

    ...-roaming horses and burros on privately-owned lands. 222.27 Section 222.27 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE RANGE MANAGEMENT Management of Wild Free-Roaming Horses and Burros § 222.27 Maintenance of wild free-roaming horses and burros on privately-owned...

  19. 20 CFR 222.20 - When determination of relationship as divorced spouse, surviving divorced spouse, or remarried...

    Science.gov (United States)

    2010-04-01

    ... divorced spouse, surviving divorced spouse, or remarried widow(er) is made. 222.20 Section 222.20 Employees... Relationship as Divorced Spouse, Surviving Divorced Spouse, or Remarried Widow(er) § 222.20 When determination of relationship as divorced spouse, surviving divorced spouse, or remarried widow(er) is made....

  20. 20 CFR 404.222 - Use of benefit table in finding your primary insurance amount from your average monthly wage.

    Science.gov (United States)

    2010-04-01

    ... insurance amount from your average monthly wage. 404.222 Section 404.222 Employees' Benefits SOCIAL SECURITY... Average-Monthly-Wage Method of Computing Primary Insurance Amounts § 404.222 Use of benefit table in finding your primary insurance amount from your average monthly wage. (a) General. We find your...

  1. Measurements of 222Rn activity in well water of the Curitiba metropolitan area (Brazil)

    Science.gov (United States)

    Corrêa, Janine N.; Paschuk, Sergei A.; Kappke, Jaqueline; Perna, Allan F. N.; França, Alana C.; Schelin, Hugo R.; Denyak, Valeriy

    2014-11-01

    Considering that 222Rn activity concentration in well water can contribute to indoor radon concentration levels, which represent a radiation risk for the public, measurements of 226Ra and 222Rn activity in well water in Curitiba, Paraná State, Brazil were performed. Each water sample was submitted to four measurements for radon concentration over an interval of three days. After two months, the same samples were submitted again to 222Rn concentration measurements with the objective of indirectly evaluating the amount of 226Ra in them. The 222Rn concentration measurements were performed with an AlphaGUARD radon monitor (SAPHYMO), and the 226Ra concentration was evaluated with the decay curves of 222Rn. Within a few hours after extraction, about 70% of water samples from monitored wells presented 222Rn concentration values above the limit of 11.1 Bq/L recommended by the EPA of the United States. The obtained activity values varied between 1.6 Bq/L and 215 Bq/L for radon concentration, and radium concentrations deviated within an interval of 0.50 Bq/L and 6.8 Bq/L. The results reveal that the biggest part of 222Rn found in water samples originated not from soluble 226Ra compounds but from gas exhalation by the soil and rocks adjacent to the well. The results point to the necessity of mitigation procedure development for better control of global alpha radioactivity in drinking water.

  2. Control of preferred (222) crystalline orientation of sputtered indium tin oxide thin films

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Duy Phong [Laboratory of Advanced Materials, University of Science, Vietnam National University, Ho Chi Minh (Viet Nam); Phan, Bach Thang [Laboratory of Advanced Materials, University of Science, Vietnam National University, Ho Chi Minh (Viet Nam); Faculty of Materials Science, University of Science, Vietnam National University, Ho Chi Minh (Viet Nam); Hoang, Van Dung; Nguyen, Huu Truong [Laboratory of Advanced Materials, University of Science, Vietnam National University, Ho Chi Minh (Viet Nam); Ta, Thi Kieu Hanh [Faculty of Materials Science, University of Science, Vietnam National University, Ho Chi Minh (Viet Nam); Maenosono, Shinya [Japan Advanced Institute of Science and Technology, Nomi, Ishikawa (Japan); Tran, Cao Vinh, E-mail: tcvinh@hcmus.edu.vn [Laboratory of Advanced Materials, University of Science, Vietnam National University, Ho Chi Minh (Viet Nam)

    2014-11-03

    We report a two-step growth process for the fabrication of (222)-plane textured indium tin oxide (ITO) films. A thin ITO seed layer was grown in mixed Argon + Oxygen gases, followed by a thick ITO deposited in Argon gas. X-Ray diffraction shows that the sputtered ITO films exhibit strongly preferred (222) crystalline orientation. The (222)-plane textured ITO films have high transmittance above 80% in the visible range and carrier concentration, mobility and resistivity in the range of 10{sup 21} cm{sup −3}, 40 cm{sup 2}/Vs and 10{sup −4} Ω·cm, respectively. The surface roughness of our (222) textured ITO films is 1.4 nm, which is one of the smallest value obtained from sputtered ITO thin films. - Highlights: • Control of preferred (222) crystalline orientation of indium tin oxide (ITO) films • A thin oxygen rich seed layer activates (222) orientation growth of overhead ITO films. • The surface roughness of (222)-plane textured ITO films is about 1.4 nm. • Carrier concentration and resistivity are about 10{sup 21} cm{sup −3} and 10{sup −4} Ω·cm, respectively.

  3. Theoretical study of the diffusion 222Rn gas on activated charcoal

    International Nuclear Information System (INIS)

    The 222Rn adsorption coefficient is the fundamental parameter characterizing activated carbon's ability to adsorb 222Rn . In this work, it has been determined the 222Rn coefficient adsorption for 222Rn activated carbon detectors. Scintillation vials were used as detectors. The measurement of the 222Rn activity adsorbed in activated carbon was made by a liquid scintillation measurement of its alpha-beta progeny decay. On the other hand, in this work a diffusion and adsorption model has been developed for the transport of 222Rn in an activated carbon porous bed. The equation that describes these processes is a partial differential equation, of the second order with respect to axial coordinate, and the first order with respect to time. The equation was numerically solved using a finites differences method. With this model the 222Rn activity adsorbed in the detector, for several situations, was calculated. The results were tested with the data obtained from series of experiences made in our laboratories. (author)

  4. (220)Rn/(222)Rn isotope pair as a natural proxy for soil gas transport.

    Science.gov (United States)

    Huxol, Stephan; Brennwald, Matthias S; Henneberger, Ruth; Kipfer, Rolf

    2013-12-17

    Radon (Rn) is a naturally occurring radioactive noble gas, which is ubiquitous in soil gas. Especially, its long-lived isotope (222)Rn (half-life: 3.82 d) gained widespread acceptance as a tracer for gas transport in soils, while the short-lived (220)Rn (half-life: 55.6 s) found less interest in environmental studies. However, in some cases, the application of (222)Rn as a tracer in soil gas is complex as its concentrations can be influenced by changes of the transport conditions or of the (222)Rn production of the soil material. Due to the different half-lives of (220)Rn and (222)Rn, the distances that can be traveled by the respective isotopes before decay differ significantly, with (220)Rn migrating over much shorter distances than (222)Rn. Therefore, the soil gas concentrations of (220)Rn and (222)Rn are influenced by processes on different length scales. In laboratory experiments in a sandbox, we studied the different transport behaviors of (220)Rn and (222)Rn resulting from changing the boundary conditions for diffusive transport and from inducing advective gas movements. From the results gained in the laboratory experiments, we propose the combined analysis of (220)Rn and (222)Rn to determine gas transport processes in soils. In a field study on soil gases in the cover soil of a capped landfill we applied the combined analysis of (220)Rn and (222)Rn in soil gas for the first time and showed the feasibility of this approach to characterize soil gas transport processes.

  5. Vibrations in the urban environment controlling {sup 222}Rn migration in soils

    Energy Technology Data Exchange (ETDEWEB)

    Wiegand, J. [University of Essen, Department 9 - Geology, Essen (Germany)

    1998-12-31

    Comparable to investigations looking for a connection of {sup 222}Rn and earthquakes, this study shows the influence of subsurface vibrations on the {sup 222}Rn concentration of the soil-gas in urban environments. Generally, the {sup 222}Rn concentration increases through vibrations induced by trains, street-traffic and activities at project sites. The spatial radius of the {sup 222}Rn increase due to vibrations reach highest values at project sites where piled foundations or metal panels are rammed into the ground (> 60 m). Along railway tracks the radius is wider (> 30 m) than along heavy traffic roads (< 25 m). The average increase of {sup 222}Rn concentrations in soil-gas due to vibrations is the highest at project sites (53%). Along heavy traffic roads the increase of {sup 222}Rn concentrations by motor vehicle traffic is higher (37%) than that by railway traffic (11.5%). The maximum increase of 400% was observed in a distance of 1 m from a railway track. In the vicinity of railway tracks a difference of the vibration influence according to unconsolidated rock (11.1%) or solid rock (11.8%) was not noticed. Beside this vibration effect, the overall {sup 222}Rn level decreases with increasing distance to the vibration source, but only at locations laying above solid rocks. The observation of the increase of {sup 222}Rn concentrations can be explained by a `pump effect`: the mechanical vibration of soil and mineral particles leads to an upward motion of the whole volume of soil-gas. Therefore, {sup 222}Rn is pumped out of the soil to the atmosphere and as a result the upward transport is increased. (author)

  6. Growth Of 222Rn By Using Merlin Gerin, Vinten 271/671 And Centronic Ionization Chambers

    International Nuclear Information System (INIS)

    Growth measurements of exp.222 Rn by using Merlin Gerin, Vinten 271/671 and Centronic 1G 11/A20 ionization chamber have been studied. The aim of this measurement is to determine the optimum growth in the seculer equilibrium of exp.222 Rn by using three ionization chambers. The optimum growth of exp.222 Rn by using merlin Gerin ionization chamber was (19.06 n 0.07) days, by using Vinten 271/671 ionization chamber was (19.20 n 0.01) days and with Centronic 1G 11/A20 ionization chamber was (19.64 n 0.43) days

  7. Contrasting behavior in octupole structures observed at high spin in 220Ra and 222Th

    International Nuclear Information System (INIS)

    Alternating-parity states connected by strong E1 transitions, characteristic of a reflection-asymmetric rotor, have been observed to high spins in the isotones 220Ra and 222Th. This level structure is observed up to Jπ=29-(31-) in 220Ra while it cannot be seen beyond J+=24+(25-) in 222Th. These observations are consistent with Woods-Saxon-Bogolyubov cranking calculations which predict that the yrast band of 222Th will undergo a shape transition at J=24ℎ, in contrast to that of 220Ra which maintains its reflection asymmetry to higher spins

  8. Copper-Catalyzed 2,2,2-Trifluoroethylthiolation of Aryl Halides.

    Science.gov (United States)

    Chen, Shouxiong; Zhang, Mengjia; Liao, Xuebin; Weng, Zhiqiang

    2016-09-01

    Herein, a copper-catalyzed 2,2,2-trifluoroethylthiolation reaction of aryl bromides and iodides with elemental sulfur, and 1,1,1-trifluoro-2-iodoethane is described. The reaction showed excellent functional group tolerance and allowed the synthesis of various substituted aryl 2,2,2-trifluoroethyl thioethers with good to excellent yields. This transformation constitutes a one-pot synthesis of 2,2,2-trifluoroethylthiolated compounds from inexpensive, readily available starting materials. Utility of the protocol was further demonstrated in the late-stage synthesis of the pirfenidone derivative. The copper thiolate species were prepared and proposed as key intermediates in the catalytic cycle. PMID:27477255

  9. Using 222 Rn for hydrograph separationin a micro basin (Luxembourg

    Directory of Open Access Journals (Sweden)

    L. Hoffmann

    2005-06-01

    Full Text Available In order to obtain information on the hydrological signature of rivers during and after heavy rain events, small catchment areas are selected as experimental sites. Hydrograph separations based on environmental tracers are performed. Natural isotopic tracers such as 18O, 2H and particularly 222Rn may help to distinguish the components dominating the outflow, particularly of 'pre-event waters', 'event waters' and 'post-event waters'. Even with moderate concentrations in groundwater, radon can be a very sensitive indicator of groundwater input into rivers. The selected microbasin under investigation is situated in the western part of Luxembourg and belongs to the Attert River catchment. At chosen points at the basin's outflow radon detectors continuously measure radon activity in water. The radon monitors are installed together with high precision thermometers, conductivity meters, flow meters and automatic water samplers for chemical analysis. Besides the continuous measurements, grab water samples are taken at different locations along the stream, most of them during periods of heavy rain events. Presented are the results of a one year measurement campaign. During the dry season i.e. during more or less continuous discharge conditions, the observed mean values do not show substantial variations and can be used as reference values. Fluctuations of the measured data during rain events are discussed and the interplay between the different parameters analysed.

  10. Hydrograph separation using 222Rn in a micro basin (Luxembourg)

    International Nuclear Information System (INIS)

    In order to get information about the hydrological signature of small rivers during and after heavy rain events, a small catchment was selected as experimental site. Hydrograph separations based on environmental tracers are performed. Natural isotopic tracers such as 18O, 2H and particularly 222Rn may help to distinguish the components dominating the outflow, particularly of pre-event waters, event waters and post-event waters. Even with moderate concentrations in groundwater, radon can be a very sensitive indicator of groundwater input into rivers. The selected microbasin under investigation is situated in the western part of Luxembourg and belong to the Attert basin, the latter being integrated in the European Network of Experimental Research Basins (ERB). Radon gas detectors are optimised to measure continuously the radon activity in water. These detectors are installed at chosen points at the basin's outflow, together with high precision thermometer, conductivity meters, flow meters and automatic water samplers for chemical analysis. Besides the continuous measurements, grab water samples are taken for radon measurements at different locations along the stream, most of them during periods of heavy rain events. Presented are preliminary results over half a year measurement campaign. During the dry season i.e. during more or less continuous discharge conditions, the observed values do not show substantial variations and can be used as reference values. High fluctuations of the measured data during heavy rain events are discussed and the interplay between the different parameters analysed. (author)

  11. Peculiarity of aqueous solutions of 2,2,2-trifluoroethanol.

    Science.gov (United States)

    Burakowski, Andrzej; Gliński, Jacek; Czarnik-Matusewicz, Bogusława; Kwoka, Paulina; Baranowski, Andrzej; Jerie, Kazimierz; Pfeiffer, Helge; Chatziathanasiou, Nikos

    2012-01-12

    Aqueous solutions of 2,2,2-trifluoroethanol appear to show a structural transition at alcohol mole fraction equal to x(TFE) = 0.05, which can be concluded from a discontinuity of the speed of sound. At the same concentration, a discontinuity was observed in the parameters of the long-living component of the positron annihilation spectrum. Moreover, the partial molar volumes of components show transition-like behavior in the range of low solute contents, which is significantly different from nonsubstituted ethanol. The peculiarities of the low concentration system correlate with minor infrared spectra changes assigned to a mode composed of the CH(2) bending and CF(3) stretching internal vibrations being sensitive to polarity of the hydration shell surrounding the solute. The majority of the spectral changes arise from a gradual shift of the equilibrium between trans ↔ gauche isomers when the composition of the solution is changing. A possible explanation for the peculiar behavior of the system is a thermodynamic equilibrium between hydrated monomers and dimers at that respective mole number. PMID:22142252

  12. Continuous measurements of outdoor {sup 222}Rn concentrations for three years at one location in Colorado

    Energy Technology Data Exchange (ETDEWEB)

    Borak, T.B.; Baynes, S.A. [Colorado State Univ., Ft. Collins, CO (United States). Dept. of Radiological Health Sciences

    1999-04-01

    Measurements were made of {sup 222}Rn concentrations outdoors in Ft. Collins, Colorado, using a continuously sampling scintillation flask between January 1993 and December 1995. These data were analyzed for hourly, daily, and seasonal variations. The average {sup 222}Rn concentration at 1 m above the ground was 18 {+-} 10 Bq m{sup {minus}3} with a geometric mean of 15 Bq m{sup {minus}3} and a geometric standard deviation of 1.7. Hourly averaged data indicated a diurnal pattern with the outdoor {sup 222}Rn concentration reaching a maximum in the early morning between 4:00 a.m. and 6:00 a.m. and a broad minimum between 1:00 p.m. and 4:00 p.m. in the afternoon. An analysis also indicated that the outdoor {sup 222}Rn concentrations were consistently lowest during the spring (March and April) and highest during the late summer (July--September).

  13. Applications of environmental radon-222 to some cases of water circulation

    International Nuclear Information System (INIS)

    We have proposed three methods to analyze water circulation and the changes caused by human activities by studying the changing distribution patterns of 222Rn concentrations in water. We investigated the results by applying the methods to some water circulation problems of Japan. The first method was a detailed analysis of the hydrogeological structure of an area, using the fact that the 222Rn concentration of water takes a value characteristic of the aquifer. In the second method we analyzed the state of mixing of surface water and groundwater by taking advantage of the fact that the 222Rn concentrations of the two are quite different. In the third method, we used the differing 222Rn concentrations in vadose water and in retention water to analyze the pressure acting on the aquifer or the groundwater

  14. 12 CFR 222.23 - Contents of opt-out notice; consolidated and equivalent notices.

    Science.gov (United States)

    2010-01-01

    ... GOVERNORS OF THE FEDERAL RESERVE SYSTEM FAIR CREDIT REPORTING (REGULATION V) Affiliate Marketing § 222.23...) Alternative contents. If the consumer is afforded a broader right to opt out of receiving marketing than...

  15. Radon 222 levels in deep well waters of Toluca municipality (county)

    International Nuclear Information System (INIS)

    The levels of Radon 222 were determined in 46 deep (50-180m) wells in the city and county of Toluca, as well as the annual radiation dose that the stomach admits when ingesting such water. The method used for the quantification of Radon 222 was liquid scintillation counting. The result revealed that levels of Radon 222 in the studied area in the range of 0 to 320 pCi l-1. In the case of the equivalent annual dose that the stomach (empty) admits due to ingestion of water from the wells, values are in an interval between 0 to 95 mrem a-1. This values are well below the level established by the International Commission of Radiological Protection (ICRP). The wells that had the higher concentration of Radon 222 were found in the regions of Lodo Prieto, Seminario; San Antonio Buenavista and La Trinidad Huichochitlan. (Author)

  16. 30 CFR 285.222 - What does MMS do with my bid?

    Science.gov (United States)

    2010-07-01

    ... to, insufficiency, illegality, anti-competitive behavior, administrative error, and the presence of... Energy Leases Competitive Lease Award Process § 285.222 What does MMS do with my bid? (a) If...

  17. Ministry of Commerce Issued 222 the Most Competitive China's Market Brands

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Recently, the Ministry of Commerce issued a total of 222 the most competitive China's market brands, which engage in 19 categories such as food, drink,apparel, household appliance and transportation.

  18. 12 CFR 222.26 - Delivery of opt-out notices.

    Science.gov (United States)

    2010-01-01

    ... SYSTEM FAIR CREDIT REPORTING (REGULATION V) Affiliate Marketing § 222.26 Delivery of opt-out notices. (a... of the Electronic Signatures in Global and National Commerce Act, 15 U.S.C. 7001 et seq. (b)...

  19. Two New Dicyanamide Coordination Polymers with Alternating Parallel Chains: {Mn(dmpz)[N(CN)2]2}2 and {Cu(dmpz)[N(CN)2]2}2

    Institute of Scientific and Technical Information of China (English)

    罗俊; 周锡庚; 侯秀峰; 吴惠霞; 翁林红; 李艳荣

    2005-01-01

    Two new dicyanamide coordination polymers, {Mn(dmpz)[N(CN)2]2}2 (1) and {Cu(dmpz)[N(CN)2]2}2 (2)(dmpz=3,5-dimethylpyrazole), were synthesized and characterized by single crystal X-ray diffraction analysis and IR spectroscopy. In 1 and 2 the metal ions have two different coordination modes, where one is coordinated to four dicyanamide anions and two monodentate dmpz molecules to form a slightly distorted octahedral geometry, while the other adopts octahedral geometry, surrounded by four nitrile N atoms and two amide N atoms of the dicyanamide anions. Both complexes contain two alternating chains that are parallel to each other.

  20. Evaluation of dose arising from 222Rn, decay products of 222Rn and 220Rn to staff from a certain nuclear power plant

    International Nuclear Information System (INIS)

    The staff of the plant was grouped on their work ranges. The annual effective dose resulted from radon and the decay products of 222Rn/220Rn is studied by measuring radon concentration with double filter membrane method and by measuring the concentration of 222Rn/220Rn short life radioactive decay products with five-count method. Based on the results, specific protection measures are proposed for high radon areas. The study results show that the monitoring data for all areas except the spent fuel pool was smaller than the recommended values by ICRP. (authors)

  1. Groundwater discharge quantification in marine, and desert environments using radium quartet, radon-222 and stable isotopes

    OpenAIRE

    Luo, Xin; 羅新

    2014-01-01

    Groundwater discharge is an important component of global water cycle. Along with groundwater discharge, large amount of chemicals are transported and loaded into surface waters. This thesis investigates groundwater discharge in both terrestrial and marine environments using isotopic approaches. Radium quartet and radon-222 (222Rn), highly concentrated in groundwater and conservatively behaving during the transport, are proved to be effective tracers in quantifying groundwater discharge in va...

  2. microRNA-222 modulates liver fibrosis in a murine model of biliary atresia

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Wen-jun; Dong, Rui; Chen, Gong, E-mail: chengongzlp@hotmail.com; Zheng, Shan

    2014-03-28

    Highlights: • The RRV infected group showed cholestasis, retardation and extrahepatic biliary atresia. • miR-222 was highly expressed, and PPP2R2A was inhibited in the murine biliary atresia model. • miR-222 profoundly modulated the process of fibrosis in the murine biliary atresia model. • miR-222 might represent a potential target for improving biliary atresia prognosis. - Abstract: microRNA-222 (miR-222) has been shown to initiate the activation of hepatic stellate cells, which plays an important role in the pathogenesis of liver fibrosis. The aim of our study was to evaluate the role of miR-22 in a mouse model of biliary atresia (BA) induced by Rhesus Rotavirus (RRV) infection. New-born Balb/c mice were randomized into control and RRV infected groups. The extrahepatic bile ducts were evaluated. The experimental group was divided into BA group and negative group based on histology. The expression of miR-222, protein phosphatase 2 regulatory subunit B alpha (PPP2R2A), proliferating cell nuclear antigen (PCNA) and phospho-Akt were detected. We found that the experimental group showed signs of cholestasis, retardation and extrahepatic biliary atresia. No abnormalities were found in the control group. In the BA group, miR-222, PCNA and Akt were highly expressed, and PPP2R2A expression was significantly inhibited. Our findings suggest that miR-222 profoundly modulated the process of fibrosis in the murine BA model, which might represent a potential target for improving BA prognosis.

  3. Evaluation of radon-222 concentration in air of workplaces at Curitiba/PR, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Del Claro, Flavia; Correa, Janine N.; Paschuk, Sergei A.; Kappke, Jaqueline; Perna, Allan F.N.; Reque, Marilson, E-mail: flaviadelclaro@gmail.com, E-mail: spaschuk@gmail.com, E-mail: janine_nicolosi@hotmail.com [Universidade Tecnologica Federal do Parana (UTFPR), Curitiba, PR (Brazil); Denyak, Valeriy, E-mail: denyak@gmail.com [Instituto de Pesquisa Pele Pequeno Principe (IPPP), Curitiba, PR (Brazil); Rocha, Zildete; Santos, Talita O., E-mail: rocha@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2013-07-01

    The isotope Rn-222 is a noble gas that is responsible for approximately half of the effective annual dose received by the world population, and has very high probability to induce the lung cancer. The goal of present research is to evaluate the activity concentration of Rn-222 in the air of workplaces at Curitiba, Parana State. Simultaneously there were performed the measurements of Rn-222 emanation from soil and building materials occurred at evaluated workplaces. Indoor measurements of Rn-222 activity were performed using CR-39 detectors. The instant radon detector AlphaGUARD (Saphymo GmbH) was used in the measurements of the average concentrations of Rn-222 in soil gas and building materials. The average concentration of indoor Rn-222 obtained in the measurements of workplaces vary between 36+/-49 Bq/m³ and 164+/-51 Bq/m³. These values are considered within the reference limit of 200 Bq/m³ established by international agencies such as the United Nations Scientific Committee on the Effects of Atomic Radiation and the International Commission on Radiological Protection, but slightly above the limit of 148 Bq/m³ established by the United States Environmental Protection Agency. The measurements involving building materials presented the concentration values of Rn-222 in a range from 427+/-310 Bq/m³ to 2053+/-700 Bq/m³. The Rn-222 concentrations in soil ranged from 31+/-2 kBq/m³ to 35+/-4 kBq/m³ and the average values of Rn-220 are found in a range of 41+/-6 kBq/m³ and 25+/-11 kBq/m³, thus the concentrations of radon gas soil are below the swedish criterion of 50 kBq/m³ that represent the minimum value for high-risk situation. (author)

  4. FAM222B Is Not a Likely Novel Candidate Gene for Cerebral Cavernous Malformations.

    Science.gov (United States)

    Spiegler, Stefanie; Kirchmaier, Bettina; Rath, Matthias; Korenke, G Christoph; Tetzlaff, Fabian; van de Vorst, Maartje; Neveling, Kornelia; Acker-Palmer, Amparo; Kuss, Andreas W; Gilissen, Christian; Fischer, Andreas; Schulte-Merker, Stefan; Felbor, Ute

    2016-07-01

    Cerebral cavernous malformations (CCMs) are prevalent slow-flow vascular lesions which harbour the risk to develop intracranial haemorrhages, focal neurological deficits, and epileptic seizures. Autosomal dominantly inherited CCMs were found to be associated with heterozygous inactivating mutations in 3 genes, CCM1 (KRIT1), CCM2 (MGC4607), and CCM3 (PDCD10) in 1999, 2003 and 2005, respectively. Despite the availability of high-throughput sequencing techniques, no further CCM gene has been published since. Here, we report on the identification of an autosomal dominantly inherited frameshift mutation in a gene of thus far unknown function, FAM222B (C17orf63), through exome sequencing of CCM patients mutation-negative for CCM1-3. A yeast 2-hybrid screen revealed interactions of FAM222B with the tubulin cytoskeleton and STAMBP which is known to be associated with microcephaly-capillary malformation syndrome. However, a phenotype similar to existing models was not found, neither in fam222bb/fam222ba double mutant zebrafish generated by transcription activator-like effector nucleases nor in an in vitro sprouting assay using human umbilical vein endothelial cells transfected with siRNA against FAM222B. These observations led to the assumption that aberrant FAM222B is not involved in the formation of CCMs. PMID:27587990

  5. Effects of immobilization by electricity and MS-222 on brown trout broodstock and their progeny

    Science.gov (United States)

    Redman, S.D.; Meinertz, J.R.; Gaikowski, M.P.

    1998-01-01

    To determine the effects of electrically and chemically induced immobilization on postspawn broodstock and their progeny, age-2 and age-3 female broodstock and age-2 male broodstock of brown trout Salmo trutta were immobilized with electricity or tricaine methanesulfonate (MS-222), stripped of their eggs or milt, and weighed. Eggs taken from electrically immobilized females were fertilized with milt taken from age-2 males that were immobilized with electricity, and eggs taken from females immobilized with MS-222 were fertilized with milt taken from age-2 males that were immobilized with MS-222. After spawning, the mortality and weight of broodstock were compared twice over a 6-month period. Egg viability and growth of offspring fry from each treatment group were also compared. Electricity induced complete and consistent immobilization in brown trout broodstock. Electrically immobilized fish were more easily handled than fish immobilized with MS-222; however, electrically immobilized fish survival (70%) was significantly less than fish immobilized with MS-222 (83%). Broodstock growth differences were only noted at 6 months postexposure, when the mean weight of electrically immobilized fish was slightly less than the weight of fish immobilized with MS-222. Broodstock immobilization by electricity did not reduce egg viability or fry growth.

  6. Waste analysis plan for 222-S dangerous and mixed waste storage area

    International Nuclear Information System (INIS)

    The 222-S Laboratory Complex, in the southeast corner of the 200 West Area, consists of the 222-S Laboratory, the 222-SA Standards Laboratory, and several ancillary facilities. Currently, 222-S Laboratory activities are in supporting efforts to characterize the waste stored in the 200 Areas single shell and double shell tanks. Besides this work, the laboratory also provides analytical services for waste-management processing plants, Tank Farms, B Plant, 242-A Evaporator Facility, Plutonium-Uranium Extraction Plant, Plutonium Finishing Plant, Uranium-Oxide Plant, Waste Encapsulation Storage Facility, environmental monitoring and surveillance programs, and activities involving essential materials and research and development. One part of the 222-SA Laboratory prepares nonradioactive standards for the 200 Area laboratories. The other section of the laboratory is used for cold (nonradioactive) process development work and standards preparation. The 219-S Waste Handling Facility has three storage tanks in which liquid acid waste from 222-S can be received, stored temporarily, and neutralized. From this facility, neutralized waste, containing radionuclides, is transferred to the Tank Farms. A 700-gallon sodium-hydroxide supply tank is also located in this facility. This plan provides the methods used to meet the acceptance criteria required by the 204-AR Waste Receiving Facility

  7. Soil water effects on concentration profiles and variations of 222Rn in a vadose zone.

    Science.gov (United States)

    Fukui, M

    1987-08-01

    Concentration profiles of 222Rn and their variations were studied to understand the vertical motion in the ground caused by fluctuations of meteorological parameters, such as precipitation, ground-water level and atmospheric pressure. A method of trapping 222Rn was developed to measure the concentration profiles by circulating and bubbling soil gas in porous cups into toluene. For locations where the water table is close to the surface, observations showed a peak concentration in the vertical profile of 222Rn at about a 40-cm depth and revealed that the concentration in soil gas decreases as soil moisture increases near the water table. Soil gas in a buried vessel also was circulated continuously to monitor 222Rn in the ground air near the surface using an ionization chamber. A rising of the water table following precipitation causes a burst of 222Rn concentration by upflow in the ground, though the concentration in the soil gas soon decreases with the intake of air above the surface due to increasing atmospheric pressure following precipitation. The concentration in soil gas again increases via the phenomenon accompanying the recovery of equilibrium in soil water between 222Rn and 226Ra. PMID:3610644

  8. Surface-water radon-222 distribution along the west-central Florida shelf

    Science.gov (United States)

    Smith, C.G.; Robbins, L.L.

    2012-01-01

    In February 2009 and August 2009, the spatial distribution of radon-222 in surface water was mapped along the west-central Florida shelf as collaboration between the Response of Florida Shelf Ecosystems to Climate Change project and a U.S. Geological Survey Mendenhall Research Fellowship project. This report summarizes the surface distribution of radon-222 from two cruises and evaluates potential physical controls on radon-222 fluxes. Radon-222 is an inert gas produced overwhelmingly in sediment and has a short half-life of 3.8 days; activities in surface water ranged between 30 and 170 becquerels per cubic meter. Overall, radon-222 activities were enriched in nearshore surface waters relative to offshore waters. Dilution in offshore waters is expected to be the cause of the low offshore activities. While thermal stratification of the water column during the August survey may explain higher radon-222 activities relative to the February survey, radon-222 activity and integrated surface-water inventories decreased exponentially from the shoreline during both cruises. By estimating radon-222 evasion by wind from nearby buoy data and accounting for internal production from dissolved radium-226, its radiogenic long-lived parent, a simple one-dimensional model was implemented to determine the role that offshore mixing, benthic influx, and decay have on the distribution of excess radon-222 inventories along the west Florida shelf. For multiple statistically based boundary condition scenarios (first quartile, median, third quartile, and maximum radon-222 inshore of 5 kilometers), the cross-shelf mixing rates and average nearshore submarine groundwater discharge (SGD) rates varied from 100.38 to 10-3.4 square kilometers per day and 0.00 to 1.70 centimeters per day, respectively. This dataset and modeling provide the first attempt to assess cross-shelf mixing and SGD on such a large spatial scale. Such estimates help scale up SGD rates that are often made at 1- to 10-meter

  9. Radon-222: tracer of geological systems dynamics. Methodology and signal processing, interpretation of radon-222 behaviour in active geological media

    International Nuclear Information System (INIS)

    of the gravimetric waves O1 and M2 in the sub-glacial laboratory of Argentiere tend to prove the relationship between mechanical deformations and variations of radon-222 activity. It is therefore theoretically possible to detect radon variations induced by the mechanical strain linked to an earthquake. However, hydrological effects (piston effect) cannot be not excluded as it is shown with data acquired on the Roselend site. On the Merapi volcano, we also demonstrate that the barometric wave S2, dissimulated in the radon activity and soils gas temperature, allows us to follow the evolution of the fracture self-sealing. This proved to be a precursory process of the 2006 eruption. These results demonstrate the strong potential of the measurement of radon-222 applied to the tracking of natural phenomena, providing, however, that one have a control on the instrumentation, a knowledge of physical processes associated with radon transport, and mostly that the tools of signals processing are applied. These tools are very promising for monitoring and understanding geodynamical processes. (author)

  10. Expression of Hpa and CD222 in bladder carcinoma and analysis of clinico-pathologic correlation

    Institute of Scientific and Technical Information of China (English)

    Shuhong Shi; Hui Zhang

    2014-01-01

    Objective:Our study aimed to investigate the relationships between the clinico-pathologic features and the hepa-ranase (Hpa) and CD222 expressions in bladder carcinoma. Methods:The expressions of Hpa and CD222 in 95 bladder carcinoma specimens and 20 paraneoplastic bladder tissues (controls) were assessed using the immunohistochemical stain-ing method. Results:The positive expression rates of Hpa and CD222 in bladder carcinoma were 68.42%and 61.05%, respectively. The positive rate of Hpa was significantly higher in the carcinoma specimens than in the control specimens (P<0.01). Similarly, the Hpa expression in the invasive bladder carcinoma was significantly higher than that in the non-invasive bladder carcinoma (P<0.01). A positive correlation was observed between the expressions of Hpa and CD222 (P<0.05). The expressions of Hpa and CD222 were significantly correlated with lymphatic invasion and TNM staging (P<0.05). The 5-year survival rate was significantly higher in negative expression of the Hpa group than that in the positive expression group (P<0.05). Compared with the non-co-positive expression group, the 5-year survival rate in the co-positive expression of Hpa and CD222 group was significantly lower (P<0.05). Conclusion:High Hpa and CD222 expressions in tumor tissues were associated with the occurrence and development of bladder carcinoma. Our results provide helpful information for the further diagnosis and therapy of bladder carcinoma.

  11. Occurrences of Uranium and Radon-222 in Groundwaters from Various Geological Environments in the Hoengseong Area

    Science.gov (United States)

    Jeong, Chan Ho; Lee, Yu Jin; Lee, Young Cheon; Choi, Hyeon Young; Yang, Jae Ha

    2016-04-01

    Groundwaters in granite, gneiss, and two-mica granite formations, including faults, in the Hoengseong area are examined to determine the relationship between their uranium and radon-222 contents and rock types. The chemical compositions of 38 groundwater samples and four surface water samples collected in the study area were analyzed. Sixteen of the samples showing high uranium and radon-222 contents were repeatedly analyzed. Surface radioactivities were measured at 30 points. The uranium and radon-222 concentrations in the groundwater samples were in the ranges of 0.02-49.3 μg/L and 20-906 Bq/L, respectively. Four samples for uranium and 35 samples for radon had concentrations exceeding the alternative maximum contaminant level of the US EPA. The chemical compositions of groundwaters indicated Ca(Na)-HCO3 and Ca(Na)-NO3(HCO3+Cl) types. The pH values ranged from 5.71 to 8.66. High uranium and radon-222 contents in the groundwaters occurred mainly at the boundary between granite and gneiss, and in the granite area. The occurrence of uranium did not show any distinct relationship to that of radon-222. The radon-222, an inert gas, appeared to be dissolved in the groundwater of the aquifer after wide diffusion along rock fractures, having been derived from the decay of uranium in underground rocks. The results in this study indicate that groundwater of neutral or weakly alkaline pH, under oxidizing conditions and with a high bicarbonate content is favorable for the dissolution of uranium and uranium complexes such as uranyl or uranyl-carbonate. Key word: uranium, radon-222, geological boundary, groundwater, chemical characteristics, surface radioactivity

  12. Knock-down of miR-221 and miR-222 in the radiosensitization of breast cancer cells

    International Nuclear Information System (INIS)

    Objective: To investigate the radiosensitizing effect of knock-down of miR-221 miR-222 on MCF-7 human breast cancer cells and explore the possible mechanism. Methods: Antisense oligonucleotides of miR-221 and miR-222 (AS-miR-221 and AS-miR-222), mediated by lipofectamine, were transfected to MCF-7 cells to knock down miR-221 and miR-222, Northern blotting was conducted to detect the expression of miR-221 and miR-222 in transfected cells. The cell apoptosis was detected by flow cytometry and Caspase-3 and Caspase-7 activity assay. Clonogenic assay was used to measure the sensitizing enhancement ratio. Target genes of miR-221 and miR-222 relevant to radio-sensitivity were searched using bioinformatics analysis. The targeted protein expression was determined by Western blot analysis. Results: The expression of miR-221 and miR-222 in the AS-miR-221/222 cells determined by Northern blotting was significantly reduced. Compared with the control group, the cell apoptosis and mitotic cell death after the radiation were significantly higher in AS-miR-221/222 cells. The sensitizing enhancement ratio was 1.87. Based on bioinformatics analysis, PTEN was a target gene of miR-221 and miR-222 which could enhance the radiosensitivity of MCF-7 cells. In AS-miR-221/222 cells, the expression of PTEN was up-regulated while pAkt down-regulated. Conclusions: AS-miR-221 and AS-miR-222 may enhance the radiosensitivity of MCF-7 breast cancer cells by up-regulating the expression of PTEN. (authors)

  13. Radon-222 from the island of hawaii: deep soils are more important than lava fields or volcanoes.

    Science.gov (United States)

    Wilkening, M H

    1974-02-01

    The mean flux of radon-222 atoms from the island of Hawaii is 0.45 atom per square centimeter per second. Lava fields occupy 50 percent of the land area, but their radon flux is only 1 percent of that from deep volcanic soils. The island yields approximately 10 curies of radon-222 per hour to the air surrounding it. The radon-222 contribuition of volcanoes is negligible.

  14. Ra-226 and Rn-222 in saline water compartments of the Aral Sea region

    International Nuclear Information System (INIS)

    Highlights: • 222Rn and 226Ra concentrations in different water compartments of the Aral Sea region. • 226Ra-analysis based on 222Rn-ingrowth versus MS-analysis after solid-phase extraction. • 226Ra in different groundwater types of the Aral Sea Basin. • 222Rn distribution in the Aral Sea, western basin. - Abstract: The Aral Sea has been shrinking since 1963 due to extensive irrigation and the corresponding decline in the river water inflow. Understanding of the current hydrological situation demands an improved understanding of the surface water/groundwater dynamics in the region. 222Rn and 226Ra measurements can be used to trace groundwater discharge into surface waters. Data of these radiometric parameters were not previously available for the study region. We determined 222Rn activities after liquid phase extraction using Liquid Scintillation Counting (LSC) with peak-length discrimination and analyzed 226Ra concentrations in different water compartments of the Amu Darya Delta (surface waters, unconfined groundwater, artesian water, and water profiles from the closed Large Aral Sea (western basin). The water samples comprise a salinity range between 1 and 263 g/l. The seasonal dynamics of solid/water interaction under an arid climate regime force the hydrochemical evolution of the unconfined groundwater in the Amu Darya Delta to high-salinity Na(Mg)Cl(SO4) water types. The dissolved radium concentrations in the waters were mostly very low due to mineral over-saturation, extensive co-precipitation of radium and adsorption of radium on coexisting solid substrates. The analysis of very low 226Ra concentrations (<10 ppq) at remote study sites is a challenge. We used the water samples to test and improve different analytical methods. In particular, we modified a procedure developed for the α-spectrometric determination of 226Ra after solid phase extraction of radium using 3M Empore™ High Performance Extraction Disks (Purkl, 2002) for the analysis of the

  15. 222Rn, 220Rn Concentrations and Miner Doses in Non-Uranium Mines in China

    International Nuclear Information System (INIS)

    A preliminary survey of 222Rn and 220Rn concentrations in non-uranium mines in China was conducted in 17 different types of mines. In total, 44 mines in 12 provinces were surveyed. The results showed that among 25 metal mines (n = 147) the arithmetic mean and geometric mean concentrations were 1214 ± 2358 and 313 ± 5.5 Bq/m3 for 222Rn, respectively (range 11–19 600 Bq/m3) and 268 ± 701 and 70 ± 4.4 Bq/m3 for 220Rn, respectively (range 222Rn, respectively (range 5–1784 Bq/m3) and 101 ± 207 and 67 ± 3.4 Bq/m3 for 220Rn, respectively (range 222Rn equilibrium factor was 0.33 ± 0.15 in underground mines and 0.47 ± 0.18 in above ground buildings. The average 222Rn concentrations in 15% of the sampled mines exceeded the workplace recommended limit of 1000 Bq/m3. The 222Rn concentration at some individual points exceeded 10 000 Bq/m3. The arithmetic mean 222Rn concentration in 14 coal mines in 6 provinces was 117 Bq/m3. Compared with the survey data from previous years, the 222Rn concentrations in coal mines had reduced significantly. However, high 222Rn exposure remains a problem in metal mines such as those for copper, tin, lead, zinc, gold and aluminum. The miners’ radon exposures were estimated from the above results. The average annual effective dose for miners in metal mines was 7.75 mSv, with doses exceeding 20 mSv in four such mines. The average dose in a rare earth mine was 1.41 mSv, of which 53% was contributed by 220Rn. The average dose in coal mines was 0.75 mSv, and in non-metal mines it was 0.38 mSv. (author)

  16. 222Rn levels in Kingsville, Texas, and vicinity near an in situ uranium mine

    International Nuclear Information System (INIS)

    An investigation of the 222Rn levels in ground water, soils, and indoor air has disclosed two 222Rn ground-water anomalies in the Kingsville, Texas, area from uranium-enriched sandstones of the Evangeline aquifer. Indoor air 222Rn levels were measured in summer 1991 (from undetectable to 3.2 pCi/l) and winter 1991-1992 (0.01 to 3.98 pCi/l) to determine seasonal extremes and risk to the public. Soil 222Rn concentration maps ranging from undetectable to 75.4 pCi/l correlate to the low levels found in homes. Results of this study are based on analyses of 218 water samples, 52 in situ soil samples, and 104 indoor air samples. Water samples were injected into a scintillation mix (EPA/EERF-Manual-78-1) and analyzed by liquid scintillation techniques. Indoor air and soil samples were collected using passive charcoal canisters and analyzed by gamma-ray detection techniques (EPA 520/5-87-005). One ground-water 222Rn anomaly lies near the permitted boundary of a large uranium deposit that is being mined. Private wells near the ore body yielded, 1,023 to 23,256 pCi/l at the well head. A second anomaly is located 2.5 mi (4 km) north of the uranium ore body near Naval Air Station, Kingsville. Private water wells in this area yielded 442 to 1,950 pCi/l 222Rn at the well head. The radon anomalies are related to subsurface mineralization, which is one of the known natural geologic hazards of this area. Indoor air 222Rn levels are well below the U.S. Environmental Protection Agency (US/EPA) action limit of 4 pCi/l. However, the high levels of 222RN in ground water should be mitigated before entry into the home environment. High 222Rn levels in ground water were reduced to background levels in household waters by use of a pre-introduction large-capacity holding tank

  17. Measurement of Rn-222 in water by absorption in polycarbonates and liquid scintillation counting

    Energy Technology Data Exchange (ETDEWEB)

    Mitev, K., E-mail: kmitev@phys.uni-sofia.bg [Sofia University ' St. Kliment Ohridski' , Department of Atomic Physics, 5 James Bourchier Blvd., 1164 Sofia (Bulgaria); Dimitrova, I. [Sofia University ' St. Kliment Ohridski' , Department of Atomic Physics, 5 James Bourchier Blvd., 1164 Sofia (Bulgaria); Zhivkova, V. [Kozloduy NPP, PP-1, Department of Radiochemistry, 3320 Kozloduy (Bulgaria); Georgiev, S.; Gerganov, G.; Pressyanov, D.; Boshkova, T. [Sofia University ' St. Kliment Ohridski' , Department of Atomic Physics, 5 James Bourchier Blvd., 1164 Sofia (Bulgaria)

    2012-06-11

    This work presents a new technique for measurement of activity concentrations of Rn-222 in water which is based on liquid scintillation counting (LSC) of polycarbonates exposed in the water. The polycarbonate material has high absorption ability to radon and when exposed in a radon-containing environment (air or water), it absorbs and concentrates radon in its volume. This property of the polycarbonate material is used for sampling {sup 222}Rn from the water. The main new element in this work is that it proposes the LSC technique for measurement of the radiation, emitted from the polycarbonate material. This radiation is due to the decay of the absorbed {sup 222}Rn and its progeny. Experimental results of LSC of polycarbonate granules and thin foils exposed in water with different activity concentrations of Rn-222 are presented. In all cases a very good linear correlation between the LS counting rate and the activity concentration of the water is found. The LSC of polycarbonates shows similar or even higher sensitivity in comparison to that of LSC of water. The estimated radon-in-water minimal detectable activity concentrations of the proposed method are similar or lower than those of the LSC and lower than those obtained by gamma spectrometry. The proposed method is simple, robust, inexpensive and avoids the need of taking water samples for laboratory analysis. It facilitates studies of the spatial distribution of {sup 222}Rn in water basins by exposure of polycarbonate specimens at different spots or depths and subsequent liquid scintillation counting.

  18. Purification and characterization of an extracellular protease from Penicillium chrysogenum Pg222 active against meat proteins.

    Science.gov (United States)

    Benito, María J; Rodríguez, Mar; Núñez, Félix; Asensio, Miguel A; Bermúdez, María E; Córdoba, Juan J

    2002-07-01

    An extracellular protease from Penicillium chrysogenum (Pg222) isolated from dry-cured ham has been purified. The purification procedure involved several steps: ammonium sulfate precipitation, ion-exchange chromatography, filtration, and separation by high-performance liquid chromatography. Based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis and gel filtration, the purified fraction showed a molecular mass of about 35 kDa. The hydrolytic properties of the purified enzyme (EPg222) on extracted pork myofibrillar proteins under several conditions were evaluated by SDS-PAGE. EPg222 showed activity in the range of 10 to 60 degrees C in temperature, 0 to 3 M NaCl, and pH 5 to 7, with maximum activity at pH 6, 45 degrees C, and 0.25 M NaCl. Under these conditions the enzyme was most active against tropomyosin, actin, and myosin. EPg222 showed collagenolytic activity but did not hydrolyze myoglobin. EPg222 showed higher activity than other proteolytic enzymes like papain, trypsin, and Aspergillus oryzae protease. The N-terminal amino acid sequence was determined and was found to be Glu-Asn-Pro-Leu-Gln-Pro-Asn-Ala-Pro-Ser-Trp. This partial amino acid sequence revealed a 55% homology with serine proteases from Penicillium citrinum. The activity of this novel protease may be of interest in ripening and generating the flavor of dry-cured meat products. PMID:12089038

  19. {sup 222}Rn, {sup 220}Rn and their progeny concentrations in offices in Hong Kong

    Energy Technology Data Exchange (ETDEWEB)

    Yu, K.N. E-mail: appetery@city.edu.hk; Cheung, T.; Guan, Z.J.; Mui, B.W.N.; Ng, Y.T

    2000-04-01

    An active sampling system using charcoal canisters and an HPGe {gamma}-spectrometer was employed to survey {sup 222}Rn and {sup 220}Rn concentrations in 65 offices in Hong Kong, and a traditional method was used to record simultaneously the potential {alpha}-energy concentrations (PAEC) of {sup 222}Rn and {sup 220}Rn progeny at the same sites. The mean values of gas concentration, PAEC and equilibrium factor for {sup 222}Rn were 48{+-}32 Bq m{sup -3}, 5.2{+-}5.1 mWL and 0.38{+-}0.13, respectively, and the corresponding values for {sup 220}Rn were 14{+-}7 Bq m{sup -3}, 2.7{+-}2.1 mWL and 0.050{+-}0.016. These values were in general higher than those in dwellings in Hong Kong, which was due to the poorer fresh air exchange in offices. Factors affecting the concentrations of {sup 222}Rn, {sup 220}Rn and their progeny were also studied. The type of air conditioners and the indoor and outdoor temperature difference show some effects on {sup 222}Rn, {sup 220}Rn and progeny concentrations, while rainfall and relative humidity affect only the progeny concentrations.

  20. Evaluation of groundwater discharge into small lakes based on the temporal distribution of radon-222

    Science.gov (United States)

    Dimova, N.T.; Burnett, W.C.

    2011-01-01

    In order to evaluate groundwater discharge into small lakes we constructed a model that is based on the budget of 222Rn (radon t1/2 5 3.8 d) as a tracer. The main assumptions in our model are that the lake's waters are wellmixed horizontally and vertically; the only significant 222Rn source is via groundwater discharge; and the only losses are due to decay and atmospheric evasion. In order to evaluate the groundwater-derived 222Rn flux, we monitored the 222Rn concentration in lake water over periods long enough (usually 1-3 d) to observe changes likely caused by variations in atmospheric exchange (primarily a function of wind speed and temperature). We then attempt to reproduce the observed record by accounting for decay and atmospheric losses and by estimating the total 222Rn input flux using an iterative approach. Our methodology was tested in two lakes in central Florida: one of which is thought to have significant groundwater inputs (Lake Haines) and another that is known not to have any groundwater inflows but requires daily groundwater augmentation from a deep aquifer (Round Lake). Model results were consistent with independent seepage meter data at both Lake Haines (positive seepage of ??? 1.6 ?? 104 m3 d-1 in Mar 2008) and at Round Lake (no net groundwater seepage). ?? 2011, by the American Society of Limnology and Oceanography, Inc.

  1. A calibration method of an ionization chamber for measuring 222Rn concentration

    International Nuclear Information System (INIS)

    When 222Rn concentration is measured with an ionization chamber, the conversion factor of ionization current to 222Rn concentration has been decided in individual case. A flow-type ionization chamber (the effective volume; 18 l) was used for measuring 222Rn concentration in this work. The conversion factor of this ionization chamber was obtained 1.11 (Bq/m3/fA) by the use of RaDEF standard source. From the results of three other literatures and this work, the following formula to calculate the conversion factor (a) was obtained as a function of the effective volume V (m3) of ionization chamber; a = (1.036 x 102-1) / [V·(log V + 6.908)] (Bq/m3/fA). (author)

  2. An application of 222Rn alpha particle's tracks to uranium exploration

    International Nuclear Information System (INIS)

    The uranium exploration method is based on the register of 222Rn alpha particles; 222Rn gas is generated in the chain 238U desintegration. The detection of alpha particles was performed with cellulose nitrate films (NTC), located in a grid at the region in study. The alpha particles produce latent tracks in the NTC films; these tracks may be enlarged by chemical etching and are observed with an ordinary optic microscope, ninety seven NTC films were used, these were distributed in an area of approximately seventeen square kilometers, located in the municipalities of Granados and Huasabas in Sonora Mexico, the detectors remain in the ground for a thirty days mean period. The results obtained show an area with high 222Rn concentration, this can be related with an underground uranium ore deposit. The more important conclusion is that the results obtained in this work can be used as preliminary results for other prospection methods in this particular area. (author)

  3. Rn-222 exhalation rates from phosphogypsum embankments subjected to fixed external activity

    Energy Technology Data Exchange (ETDEWEB)

    Rabi, Jose A. [Pontificia Univ. Catolica de Minas Gerais, MG (Brazil)]. E-mail: jrabi@pucpcaldas.br; Silva, Nivaldo C. da [Comissao Nacional de Energia Nuclear (CNEN), Pocos de Caldas, MG (Brazil). Lab. de Pocos de Caldas]. E-mail: ncsilva@cnen.gov.br

    2003-07-01

    Half of the average total dose received by humans worldwide corresponds to the annual effective dose due to {sup 222} Rn. This radionuclide is found in phosphogypsum, which is a by-product from phosphate fertilizer industries. Although there is a global interest in finding large-scale usage of this material, environmental issues related to its disposal and management still remain, as far as the {sup 222} Rn exhalation rate is concerned. Radon transport mechanism through phosphogypsum-based embankments is a rather complex process and depends upon many physical factors as porosity, moisture, temperature and emanation power. In this paper, an existing mathematical model was applied to simulate {sup 222} Rn transport in a one-dimensional porous media domain and under a steady-stage regime. As a first approach, natural convection effects were neglected and boundary conditions included no-flux at the base of the embankment and constant concentration activity at its top. (author)

  4. Measuring techniques for environmental 3H, 14C and 222Rn by liquid scintillation counter

    International Nuclear Information System (INIS)

    Measuring techniques for environmental 3H, 14C and 222Rn with a liquid scintillation counter have been studied. 3H in environmental water was enriched by electrolysis and measured with a low background liquid scintillation counter. By this technique, 3H concentration of ground water, river water, sea water and rain water at Tokyo was founded to be 0.1 ∼ 2.5 Bq/1. 14C in taurine and ethyl-alcohol was measured directly liquid scintillation counter. By this 14C measuring, natural products, contain low level 14C, were distinguished from synthesised products contain no 14C. 222Rn in toluene extracted from environmental water or air was measured by scintillation pulse interval analysis method. By this technique, 222Rn was able to be measured under very low background counting rate, 0.03cpm, and high efficiency. (author)

  5. Radon-222 content in the internal atmosphere of Hungarian residential buildings

    International Nuclear Information System (INIS)

    The use in home buildings in Hungary of some substitute materials, e.g., coal-ash, fly-ash, etc., caused greater background radiation than the traditional building materials because of their higher content of natural radioactivity. The radon-222 concentration was measured in 1182 flats (apartments) along with the concentrations of its short-lived daughter elements and radon-220 in room air and the radiation dose to the epithelium of the bronchial tubes of the lung was estimated. The average annual radon-222 concentration in open air was estimated as being 0.2 pCi/l. To confirm this estimate the radon-222 concentration in the atmosphere near the surface of the earth and its annual fluctuation was measured. (U.S.)

  6. Peak tailing correction in measurement of 222Rn/220Rn activity concentration with α spectrum method

    International Nuclear Information System (INIS)

    α spectrum method is one of the most important methods in measurement of 222Rn/220Rn concentration in environment. However, the peak tailing from high energy particles is an obstacle for accurate measurement. To improve the accuracy of measurement, study on the mechanism and effect of the tailing were carried out, and calibrating experiments on peak tailing correction factors were also realized using ERS-2 monitor. The peak tailing correction factors and calibration factors of 222Rn and 220Rn were measured by experiment and their accuracy were also tested. It is suggested that during calibrating α spectrum monitor of 222Rn/220Rn activity concentration, the peak tailing correction and calibration factors should be recalibrated if necessary. (authors)

  7. Exhalation of {sup 222}Rn from phosphogypsum piles located at the Southwest of Spain

    Energy Technology Data Exchange (ETDEWEB)

    Duenas, C. [Department of Applied Physics I, Faculty of Science, University of Malaga, Campus de Teatinos, 29071 Malaga (Spain)]. E-mail: mcduenas@uma.es; Liger, E. [Department of Applied Physics II, Technical College of Informatic Engineering, University of Malaga, 29071 Malaga (Spain); Canete, S. [Department of Applied Physics I, Faculty of Science, University of Malaga, Campus de Teatinos, 29071 Malaga (Spain); Perez, M. [Department of Applied Physics I, Faculty of Science, University of Malaga, Campus de Teatinos, 29071 Malaga (Spain); Bolivar, J.P. [Department of Applied Physics, EPS, University of Huelva, 21819 Huelva (Spain)

    2007-06-15

    Phosphogypsum (PG) is a waste product of the phosphoric acid production process and contains, generally, high activity concentrations of uranium series radionuclides. It is stored in piles formed over the last 40 years close to the town of Huelva (Southwest of Spain). The very broad expanse of the PG piles (about 1200 ha) produces a local, but unambiguous, radioactive impact to their surroundings. In 1992, the regional government of Andalusia restored an area of 400 ha by covering it with a 25-cm thick layer of natural soil and, currently, there is an additional zone of 400 ha in course of restoration (unrestored) and the same area of active PG stacks. Due to the high activity concentration of {sup 226}Ra in active PG stacks (average 647 Bq kg{sup -1}), a significant exhalation of {sup 222}Rn could be produced from the surface of the piles. Measurements have been made of {sup 222}Rn exhalation from active PG stacks and from restored and unrestored zones. The {sup 222}Rn exhalation from unrestored zones is half of that of the active PG stacks. Following restoration, the {sup 222}Rn exhalation is approximately eight times lower than the active PG stacks. The activity concentrations of natural radionuclides ({sup 226}Ra, {sup 40}K, {sup 232}Th) in the mentioned zones have been determined. This study was also conducted to determine the effect of {sup 226}Ra activity concentration on the {sup 222}Rn exhalation, and a good correlation was obtained between the {sup 222}Rn exhalation and {sup 226}Ra activity, porosity and density of soil.

  8. Design and construction of a system to determine Radon-222 through alpha spectroscopy; Diseno y construccion de un sistema para determinar Radon-222 mediante espectroscopia alfa

    Energy Technology Data Exchange (ETDEWEB)

    Bonifacio M, J. [Universidad Autonoma del Estado de Mexico. Facultad de Quimica. Toluca (Mexico)

    1991-12-31

    The purpose of this work consists in the design a radon-222 gas measurement system utilizing a surface barrier detector with the objective to obtain a more accurate measurement for this isotope through an alpha particle spectrum and so to address as to avoid the activity influence of the descendants of short half-life, which are too beta particles emitters, already other methods it must be correction series to obtain the real value of radon activity. Here are presented the general properties properties of radon, the experimental part description indicating the design to measure the radon-222 gas and its parts, as well as too the standard separation of radium-226 starting from carnotite mineral. Finally, it is presented the results obtained with a discussion about it. (Author) results obtained with a discussion about it. (Author)

  9. An extensive indoor {sup 222}Rn/{sup 220}Rn monitoring in North-East India

    Energy Technology Data Exchange (ETDEWEB)

    Dwivedi, K.K. [Department of Science and Technology, Embassy of India, 2536 Massachusetts Avenue, NW, Washington, DC 20008 (United States)]. E-mail: kkdwivedi@yahoo.com; Mishra, R. [Italian National Agency for Environmental Protection and Technical Services (APAT), Via. V. Brancati 48, Rome 00144 (Italy); Tripathy, S.P. [Italian National Agency for Environmental Protection and Technical Services (APAT), Via. V. Brancati 48, Rome 00144 (Italy)

    2005-11-15

    The behaviour of ubiquitous radon (Rn222), thoron (Rn220) and their progeny in the indoor atmosphere generally reflect a complex interplay between a number of processes, the most important of which are radioactive {alpha}-decay, ventilation, attachment to aerosols and deposition on the surfaces. The present work involved a long-term (1997-2000) passive monitoring of Rn222 and Rn220 in the indoor environment of the North-Eastern region of India. This region being a zone of high seismicity, the indoor radon and thoron measurement of the region will provide a better insight and a valuable database for any study related to radon and thoron anomalies.

  10. Mineral water {sup 222} Rn activity decrease due to consumption habits; Determinacao do decrescimo da atividade de radonio-222 em aguas minerais simulando habitos de consumo

    Energy Technology Data Exchange (ETDEWEB)

    Cipriani, Moacir; Taddei, Maria Helena Tirollo; Silva, Nivaldo Carlos da [Comissao Nacional de Energia Nuclear (CNEN), Pocos de Caldas, MG (Brazil). Laboratorio

    2001-07-01

    Mineral waters from the Pocos de Caldas Plateau springs, an elevated region with high natural radioactivity, in the State of Minas Gerais, Brazil, have significant {sup 222} Rn concentration on site. The highest concentration in the waters are from: Fonte Villela - Aguas da Prata ({approx} 1000 Bql{sup -1}); Fonte Grande Hotel - Pocinhos do Rio Verde ({approx} 400 Brq{sup -1}) and Fonte CNEN Lab - Pocos de Caldas ({approx} 290 Bql{sup -1}). These waters are used by the population as drinking water and due to consumption habits, can lead to internal doses above accepted limits for the public. This work deals with the decrease of {sup 222} Rn activity in mineral waters fro two different popular consumption habits, and with the adult effective dose equivalent reduction due to water consumption habits. It has been found that the estimated dose based on the biokinetic Crawford-Brown model, can be one fourth of dose based on {sup 222} Rn activity on site. (author)

  11. Measurements of the radon-222 concentration in residences of Lima - Peru; Mediciones de la concentracion de radon 222 en residencias de Lima - Peru

    Energy Technology Data Exchange (ETDEWEB)

    Pereyra, P.; Lopez, M. E.; Perez, B., E-mail: ppereyr@pucp.edu.pe [Pontificia Universidad Catolica del Peru, Seccion Fisica, Av. Universitaria 1801, Lima (Peru)

    2014-08-15

    The measurement of the Radon-222 levels was realized in the first semester of 2013 in residences corresponding to 16 districts of the metropolitan area of Lima, including to the zones North, Center and South of the city, during one period of 3 to 6 months in continuous form, with measurement periods of 1 to 2 months. The houses where the measurements were made were selected considering diverse variables as antiquity, construction materials, coatings, soil type, occupational use of the monitored rooms, etc. The measurements were realized in basements, first and second floor of the residences. For the Radon-222 measurements passive detectors of cellulose nitrate (Lr-115) were used. The procedure of data collection, dosimeters reading and the measurement results are shown in this work; this monitoring is the first one that is carried out in this city. The results are only indicators of the present radon rate, by the detectors type not is possible to discriminate the presence of the Radon-222 descendants. (Author)

  12. 48 CFR 52.222-23 - Notice of Requirement for Affirmative Action To Ensure Equal Employment Opportunity for...

    Science.gov (United States)

    2010-10-01

    ... Affirmative Action To Ensure Equal Employment Opportunity for Construction. 52.222-23 Section 52.222-23... Affirmative Action To Ensure Equal Employment Opportunity for Construction. As prescribed in 22.810(b), insert... with Executive Order 11246, as amended, and the regulations in 41 CFR 60-4 shall be based on (1)...

  13. 34 CFR 222.22 - How does the Secretary treat compensation from Federal activities for purposes of determining...

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false How does the Secretary treat compensation from Federal activities for purposes of determining eligibility and payments? 222.22 Section 222.22 Education Regulations....22 How does the Secretary treat compensation from Federal activities for purposes of...

  14. 40 CFR 436.222 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Effluent limitations guidelines... technology currently available. 436.222 Section 436.222 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS MINERAL MINING AND PROCESSING POINT SOURCE...

  15. 48 CFR 852.222-70 - Contract Work Hours and Safety Standards Act-nursing home care contract supplement.

    Science.gov (United States)

    2010-10-01

    ... Safety Standards Act-nursing home care contract supplement. 852.222-70 Section 852.222-70 Federal...—nursing home care contract supplement. As prescribed in 822.305, for nursing home care requirements, insert the following clause: Contract Work Hours and Safety Standards Act—Nursing Home Care...

  16. 24 CFR 1000.222 - Are there separate IHP requirements for small Indian tribes and small TDHEs?

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Are there separate IHP requirements for small Indian tribes and small TDHEs? 1000.222 Section 1000.222 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING...

  17. 9 CFR 381.222 - States designated under paragraph 5(c) of the Act; application of regulations.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false States designated under paragraph 5(c) of the Act; application of regulations. 381.222 Section 381.222 Animals and Animal Products FOOD... Designating Establishments With Operations Which Would Clearly Endanger the Public Health; Disposition...

  18. 47 CFR 90.719 - Individual channels available for assignment in the 220-222 MHz band.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Individual channels available for assignment in... Licensing and Use of Frequencies in the 220-222 MHz Band § 90.719 Individual channels available for assignment in the 220-222 MHz band. (a) Channels 171 through 200 are available to both Government and...

  19. {sup 222}Rn monitoring in the radioactive storage of IPEN/CNEN-SP, Brazil; Monitoracao de Rn-222 nos galpoes de armazenamento de rejeitos radioativos do IPEN

    Energy Technology Data Exchange (ETDEWEB)

    Manocchi, Fabio Henrique

    2014-07-01

    Some radionuclides that make up the radioactive series are noted for their contribution to the total exposure to which individuals are subjected, an important example is known as radon {sup 222}Rn and their descendants, responsible for more than half of the radiation dose received by the population due to natural sources. In this work the effective dose received by the workers of the Management of Radioactive Waste in IPEN due to inhalation of {sup 222}Rn in storage sheds from treated and untreated radioactive waste was evaluated. Concentrations of {sup 222}Rn inside the sheds of treated and untreated radioactive waste G3 and G4 were determined by the technique of passive detection with solid state nuclear track (SSNTD) detectors. The detector used was CR-39 inserted in a diffusion chamber type NRPB. A total of 12 internal points and 1 external point were monitored in the shed radioactive waste treated G4 and 13 points in the shed radioactive waste untreated G3, for a period of 11 months between June 2012 and May 2013. Concentrations ranged 0.73 ± 0.08 to 4.55 ± 0.16 kBq∙m{sup -3} among the monitoring periods in the shed G4 and between 0.61 ± 0.07 and 2.94 ± 0.12 kBq∙m{sup -3} in the shed G3. The effective dose due to inhalation of {sup 222}Rn inside the sheds radioactive waste was calculated according to the procedures of the International Commission on Radiological Protection (ICRP) from a conversion factor of dose, the mean concentration of {sup 222}Rn in the air and time of exposure of individuals. The dose values for G4 and G3 are 15.70 and 9.27 mSv∙a{sup -1} respectively, this being greater than the value established by the National Nuclear Energy Commission (CNEN) and recommended by the International Commission on Radiological Protection (ICRP) 20 mSv / a for occupationally exposed individuals, thus indicating the need for mitigation measures. It should, however, report that was considered a very conservative assumption of 2,000 hours of work on

  20. In situ soil 222Rn and 220Rn and their relationship with meteorological parameters in tropical Northern Peninsular Malaysia

    International Nuclear Information System (INIS)

    This study focused on the relationship between soil 222Rn and 220Rn concentrations and meteorological parameters (temperature, pressure, humidity, and terrestrial gamma radiation) in Northern Peninsular Malaysia. Measurements of in situ soil 222Rn and 220Rn concentrations were performed in surface air and at a sampling depth of 50 cm using two active techniques: RAD7 radon detector and radon continuous monitor (Sun Nuclear Corporation). The surface air 222Rn concentration ranged from 6 Bq m−3 to 79 Bq m−3, whereas at the depth of 50 cm, the 222Rn and 220Rn concentrations varied from 133 Bq m−3 to 143,059 Bq m−3 and from 55 Bq m−3 to 403 Bq m−3, respectively. The gamma dose rate (DR) in air was measured using a GR-135 spectrometer (Exploranium). The dose rate varied from 80 nGy h−1 to 258 nGy h−1. The 222Rn concentration in the soil (143 kBq m−3) was high considering that the concentration in typical soil samples is only 40 kBq m−3. The 222Rn concentration in surface air varied within the recommended activity values prescribed by the United States Environmental Protection Agency and the International Commission on Radiological Protection. Weak positive and negative correlations were observed between the (222Rn and 220Rn) concentrations and the meteorological parameters. - Highlights: • DR varies (80–258 nGy h−1), no correlation between acidity and radon concentration. • 222Rn in soil (143 kBq m−3) high considering than in typical soil 40 kBq m−3. • 222Rn in surface air varied within EPA and ICRP. • All sites exhibited larger DR compared with the world of 84 nGy h−1 except for two sites. • A statistically significant correlation between 222Rns–220Rn

  1. miR-221和miR-222在胃癌中的表达及临床意义%Expression of miR-221 and miR-222 in Gastric Cancer and its Clinical Significance

    Institute of Scientific and Technical Information of China (English)

    金晶; 闫竞一; 薛向阳; 武文一; 黄颖鹏; 朱冠保; 沈贤

    2011-01-01

    [Purpose] To investigate the expression of miR-221 and miR-222 in gastric cancer and its relationship with clinicopathologic features. [ Method ] The expression of miR-221 and miR-222 in 32 cases of gastric cancer tissues and their matched non-tumor adjacent tissues was examined by stem-loop RT-PCR. And the correlation with clinicopathologic features was investigated. [ Resuits] The expression of miR-221 and miR-222 in gastric cancer tissues was significantly higher than those in adjacent tissues (P<0.05). The ratio of miR-221/miR-222 expression had significant difference (P=0.05). The expression of miR-222 was related to differentiation (P=0.046); the expression of miR-221 was related to lymph node metastasis(P=0.013). [Conclusion] The expressions of miR-221 and miR-222 in gastric cancer markedly up regulation,they are important markers for gastric cancer,and they may play different effect with different stages in gastric cancer.%[目的]探讨miR-221和miR-222在胃癌中的表达及与临床病理特征的关系.[方法]应用茎环RT-PCR方法检测32例胃癌及癌旁胃黏膜组织中miR-221和miR-222表达,分析miR-221和miR-222表达与胃癌临床病理指标的关系.[结果]胃癌组织miR-221和miR-222表达明显高于对应的正常胃黏膜组织(P<0.05),且胃癌与正常胃黏膜组织中miR-221和miR-222比值也有显著性差异(P=0.05).miR-222表达与胃癌分化程度相关(P=0.046);miR-221表达与淋巴结转移相关(P=0.013).[结论]miR-221和miR-222在胃癌中表达明显上调是胃癌的重要标志.但两者在胃癌发生发展的不同阶段,可能发挥不同的效应.

  2. Felodipine-diazabicyclo 2.2.2 octane-water (1/1/1)

    DEFF Research Database (Denmark)

    Solanko, K. A.; Surov, A. O.; Perlovich, G. L.;

    2012-01-01

    The title compound, C18H19Cl2NO4 center dot C6H12N2 center dot H2O, is a cocrystal hydrate containing the active pharmaceutical ingredient felodipine and diazabicyclo[2.2.2]octane (DABCO). The DABCO and water molecules are linked through O-H center dot center dot center dot N hydrogen bonds into...

  3. 20 CFR 222.21 - When marriage is terminated by final divorce.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When marriage is terminated by final divorce... Widow(er) § 222.21 When marriage is terminated by final divorce. A final divorce, often referred to as an absolute divorce, completely dissolves the marriage relationship and restores the parties to...

  4. Measurement of radon 222 in drinking water and air by liquid scintillation

    International Nuclear Information System (INIS)

    This is a brief description of the liquid scintillation measuring method for determining radon 222 in drinking water and air. Discussed are the advantages of this method and its reliability or accuracy, as well as some conclusions from the results. (orig.)

  5. 14 CFR 222.5 - Cancellation or conditioning of a Statement of Authorization.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Cancellation or conditioning of a Statement... § 222.5 Cancellation or conditioning of a Statement of Authorization. A Statement of Authorization may be canceled or made subject to additional terms, conditions, or limitations, at any time, with...

  6. Proline Catalyzed Asymmetric Aldol Reaction between Methyl Ketones and 1-Aryl-2,2,2-trifluoroethanones

    Institute of Scientific and Technical Information of China (English)

    QIU Li-Hua; SHEN Zong-Xuan; SHI Chang-Qing; LIU Yan-Hua; ZHANG Ya-Wen

    2005-01-01

    Direct asymmetric aldol addition of methyl ketones to 2,2,2-trifluoro-1-phenylethanone and its ring-substituted derivatives was achieved using L-proline as a chiral promoter. Various optically active β-trifluoromethyl-β-hydroxy ketones were obtained in almost quantitative yields with moderate enantioselectivities up to 64 % ee.

  7. 34 CFR 222.30 - What is “free public education”?

    Science.gov (United States)

    2010-07-01

    ... defined in § 222.2, the following definition applies to this part: Free public education. (1) The term... of paragraph (1)(i) of this definition, education is provided at public expense if— (i) There is no... paragraph (1)(iv) of this definition, education provided under public supervision and direction...

  8. 12 CFR 222.22 - Scope and duration of opt-out.

    Science.gov (United States)

    2010-01-01

    ... SYSTEM FAIR CREDIT REPORTING (REGULATION V) Affiliate Marketing § 222.22 Scope and duration of opt-out.... (2) Continuing relationship—(i) In general. If the consumer establishes a continuing relationship... connection with— (A) A single continuing relationship or multiple continuing relationships that the...

  9. Efficient direct 2,2,2-trifluoroethylation of indoles via C-H functionalization.

    Science.gov (United States)

    Tolnai, Gergely L; Székely, Anna; Makó, Zita; Gáti, Tamás; Daru, János; Bihari, Tamás; Stirling, András; Novák, Zoltán

    2015-03-14

    A novel highly C3 selective metal free trifluoroethylation of indoles using 2,2,2-trifuoroethyl(mesityl)-iodonium triflate was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with high functional group tolerance. Beyond the synthetic developments, quantum chemical calculations provide a deeper understanding of the transformation. PMID:25682991

  10. Fungal Origins of the Bicyclo[2.2.2]diazaoctane Ring System of Prenylated Indole Alkaloids

    DEFF Research Database (Denmark)

    Finefield, Jennifer M.; Frisvad, Jens C.; Sherman, David H.;

    2012-01-01

    Over eight different families of natural products consisting of nearly 70 secondary metabolites that contain the bicyclo[2.2.2]diazaoctane ring system have been isolated from various Aspergillus, Penicillium, and Malbranchea species. Since 1968, these secondary metabolites have been the focus of ...

  11. 12 CFR 222.25 - Reasonable and simple methods of opting out.

    Science.gov (United States)

    2010-01-01

    ... FEDERAL RESERVE SYSTEM FAIR CREDIT REPORTING (REGULATION V) Affiliate Marketing § 222.25 Reasonable and... electronically mailed or processed at an Internet Web site, if the consumer agrees to the electronic delivery of... opt-out under the Act, and the affiliate marketing opt-out under the Act, by a single method, such...

  12. Design and construction of a system to analyze Radon 222 by means of alpha spectroscopy

    International Nuclear Information System (INIS)

    Design and construction of a system to measure gaseous Radon 222 which arise from a source of Radium 226 electrodeposited in a stainless disc is described. Such a system allows to differentiate the energies of radium where they come from, as well as energies of daughter products. In this way it is possible to have a more precise measure of the alpha activity of this isotope. The system was constructed in a stainless steel hermetic container made of the camera, a cape and a valve, the used sample was a standards of Radium 226 attained from carnotite ore. The Radon 222 alpha particles, as well as the alpha particles of its decay products namely Polonium 210. Polonium 218 and Polonium 214 were identified by a surface barrier detector. The results in this manner obtained shows clearly well definite peaks of Radon 222 and also peaks of the Radon 222 daughter products with energies of 5.43, 5.31, 6.0 and 7.69 Mev respectively. The system allows to separate and to indentify the energies of Radon and its daughter products coming directly from a standard solid sample of Radium 226 (Author)

  13. Distribution Log Normal of 222 Rn in the state of Zacatecas, Mexico

    International Nuclear Information System (INIS)

    In this work the evaluation of the concentration of 222 Rn in air for Zacatecas is shown. The Solid State Nuclear Track Detectors were used as the technique for the realization of the measurements in large scale with cellulose nitrate LR-115, type 2, in open chambers of 222 Rn. The measurements were carried out during three months in different times of the year. In the results it is presented the log normal distribution, arithmetic mean and geometric media for the concentration at indoor and outdoor of residence constructions, the concentration at indoor of occupational constructions and in the 57 municipal heads of the state of Zacatecas. The statistics of the values in the concentration showed variation according to the time of the year, obtaining high quantities in winter seasons for both cases. The distribution of the concentration of 222 Rn is presented in the state map for each one of the municipalities, representing the measurement places in the entire state of Zacatecas. Finally the places where the values in the concentration of 222 Rn in air are near to the one limit settled down by the EPA of 148 Bq/m3 are presented. (Author)

  14. Prediction of {sup 222} Rn exhalation rates from phosphogypsum based stacks. Part I: parametric mathematical modeling

    Energy Technology Data Exchange (ETDEWEB)

    Rabi, Jose A. [Pontificia Univ. Catolica de Minas Gerais, Pocos de Caldas, MG (Brazil). Faculdade de Engenharia Civil]. E-mail: jrabi@pucpcaldas.br; Mohamad, Abdulmajeed A. [The University of Calgary, Alberta (Canada). Faculty of Engineering. Dept. of Mechanical and Manufacturing Engineering]. E-mail: amohamad@enme.ucalgary.ca

    2004-07-01

    Radon-222 is a radionuclide exhaled from phosphogypsum by-produced at phosphate fertilizer industries. Alternative large-scale application of this waste may indicate a material substitute for civil engineering provided that environmental issues concerning its disposal and management are overcome. The first part of this paper outlines a steady-state two-dimensional model for {sup 222}Rn transport through porous media, inside which emanation (source term) and decay (sink term) exist. Boussinesq approach is evoked for the laminar buoyancy-driven interstitial air flow, which is also modeled according to Darcy-Brinkman formulation. In order to account for simultaneous effects of entailed physical parameters, governing equations are cast into dimensionless form. Apart from usual controlling parameters like Reynolds, Prandtl, Schmidt, Grashof and Darcy numbers, three unconventional dimensionless groups are put forward. Having in mind {sup 222}Rn transport in phosphogypsum-bearing porous media, the physical meaning of those newly introduced parameters and representative values for the involved physical parameters are presented. A limiting diffusion-dominated scenario is addressed, for which an analytical solution is deduced for boundary conditions including an impermeable phosphogypsum stack base and a non-zero fixed concentration activity at the stack top. Accordingly, an expression for the average Sherwood number corresponding to the normalized {sup 222}Rn exhalation rate is presented.

  15. Measurement of 222Rn indoors and outdoors. Progress report, June 1, 1982-May 31, 1983

    International Nuclear Information System (INIS)

    Research progress is reported on a study of the levels and variability of Radon 222 both indoors and outdoors. Sensors were deployed in a single family dwelling and in a high-rise apartment building. Temperature, pressure, relative humidity, rainfall, and wind data were also collected at these sites. Modeling of indoor radon concentrations has been initiated

  16. miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

    Science.gov (United States)

    Roscigno, Giuseppina; Romano, Giulia; Diaz-Lagares, Angel; Iaboni, Margherita; Donnarumma, Elvira; Fiore, Danilo; De Marinis, Pasqualino; Soini, Ylermi; Esteller, Manel; Condorelli, Gerolama

    2013-01-01

    Glioblastoma multiforme (GBM) is one of the most deadly types of cancer. To date, the best clinical approach for treatment is based on administration of temozolomide (TMZ) in combination with radiotherapy. Much evidence suggests that the intracellular level of the alkylating enzyme O6-methylguanine–DNA methyltransferase (MGMT) impacts response to TMZ in GBM patients. MGMT expression is regulated by the methylation of its promoter. However, evidence indicates that this is not the only regulatory mechanism present. Here, we describe a hitherto unknown microRNA-mediated mechanism of MGMT expression regulation. We show that miR-221 and miR-222 are upregulated in GMB patients and that these paralogues target MGMT mRNA, inducing greater TMZ-mediated cell death. However, miR-221/miR-222 also increase DNA damage and, thus, chromosomal rearrangements. Indeed, miR-221 overexpression in glioma cells led to an increase in markers of DNA damage, an effect rescued by re-expression of MGMT. Thus, chronic miR-221/222-mediated MGMT downregulation may render cells unable to repair genetic damage. This, associated also to miR-221/222 oncogenic potential, may poor GBM prognosis. PMID:24147153

  17. MiR-221/222 target the DNA methyltransferase MGMT in glioma cells.

    Directory of Open Access Journals (Sweden)

    Cristina Quintavalle

    Full Text Available Glioblastoma multiforme (GBM is one of the most deadly types of cancer. To date, the best clinical approach for treatment is based on administration of temozolomide (TMZ in combination with radiotherapy. Much evidence suggests that the intracellular level of the alkylating enzyme O(6-methylguanine-DNA methyltransferase (MGMT impacts response to TMZ in GBM patients. MGMT expression is regulated by the methylation of its promoter. However, evidence indicates that this is not the only regulatory mechanism present. Here, we describe a hitherto unknown microRNA-mediated mechanism of MGMT expression regulation. We show that miR-221 and miR-222 are upregulated in GMB patients and that these paralogues target MGMT mRNA, inducing greater TMZ-mediated cell death. However, miR-221/miR-222 also increase DNA damage and, thus, chromosomal rearrangements. Indeed, miR-221 overexpression in glioma cells led to an increase in markers of DNA damage, an effect rescued by re-expression of MGMT. Thus, chronic miR-221/222-mediated MGMT downregulation may render cells unable to repair genetic damage. This, associated also to miR-221/222 oncogenic potential, may poor GBM prognosis.

  18. Indoor radon (Rn-222) concentration measurements in Cyprus using high-sensitivity portable detectors

    CERN Document Server

    Anastasiou, T; Christofides, S; Christodoulides, G

    2003-01-01

    Using high--sensitivity radon (Rn-222) portable detectors, the airborne Rn-222 concentration in the interior of various Cypriot buildings and dwellings was measured. For each preselected building and dwelling, a calibrated detector was put into a closed room, and the Rn-222 concentration was registered in sampling intervals of 2 to 4 hours for a total counting time of typically 48 hours. Rn-222 activity concentrations were found to be in the range of 6.2 to 102.8 Bq/m**3, with an overall arithmetic mean value of (19.3 +- 1.6) Bq/m**3. This value is by a factor of two below the world average (population-weighted) value of 39 Bq/m**3. The total annual effective dose equivalent to the Cypriot population was calculated to be between 0.16 and 2.6 mSv with an overall arithmetic mean value of (0.49 +- 0.04) mSv.

  19. 20 CFR 222.31 - Relationship as child for annuity and lump-sum payment purposes.

    Science.gov (United States)

    2010-04-01

    ... UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Child § 222.31 Relationship as... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Relationship as child for annuity and lump... the employee. For procedures on how a determination of the person's relationship to the employee...

  20. 20 CFR 222.44 - Other relationship determinations for lump-sum payments.

    Science.gov (United States)

    2010-04-01

    ... THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222.44 Other relationship determinations for lump-sum payments. Other claimants will be considered to... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Other relationship determinations for...

  1. 20 CFR 222.24 - Relationship as remarried widow(er).

    Science.gov (United States)

    2010-04-01

    ... FAMILY RELATIONSHIPS Relationship as Divorced Spouse, Surviving Divorced Spouse, or Remarried Widow(er) § 222.24 Relationship as remarried widow(er). (a) New eligibility. A claimant will have the relationship... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Relationship as remarried widow(er)....

  2. 20 CFR 222.41 - Determination of relationship and support for parent.

    Science.gov (United States)

    2010-04-01

    ... RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222.41 Determination of relationship and support for parent. (a) Annuity claimant. For purposes of applying for an... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Determination of relationship and support...

  3. 20 CFR 222.30 - When determinations of relationship as child are made.

    Science.gov (United States)

    2010-04-01

    ... RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Child § 222.30 When determinations of relationship as child are made. (a) Determinations will be made regarding a person's relationship as the child... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When determinations of relationship as...

  4. 36 CFR 222.23 - Removal of other horses and burros.

    Science.gov (United States)

    2010-07-01

    ... 36 CFR 261.7 and 262.10. ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Removal of other horses and... AGRICULTURE RANGE MANAGEMENT Management of Wild Free-Roaming Horses and Burros § 222.23 Removal of...

  5. 34 CFR 222.18 - What amount does the Secretary forgive?

    Science.gov (United States)

    2010-07-01

    ... Secretary forgive? For an LEA that meets the requirements of § 222.14(a) (timely filed forgiveness request... overpayment as follows: (a) Forgiveness in whole. The Secretary forgives the eligible overpayment in whole if... preceding the date of its forgiveness request (“preceding fiscal year”) is ten percent or less of its...

  6. 48 CFR 52.222-5 - Davis-Bacon Act-Secondary Site of the Work.

    Science.gov (United States)

    2010-10-01

    ... Clauses 52.222-5 Davis-Bacon Act—Secondary Site of the Work. As prescribed in 22.407(h), insert the following provision: Davis-Bacon Act—Secondary Site of the Work (JUL 2005) (a)(1) The offeror shall notify... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Davis-Bacon...

  7. 48 CFR 52.222-4 - Contract Work Hours and Safety Standards Act-Overtime Compensation.

    Science.gov (United States)

    2010-10-01

    ... duplicate those required for construction work by Department of Labor regulations at 29 CFR 5.5(a)(3... CLAUSES Text of Provisions and Clauses 52.222-4 Contract Work Hours and Safety Standards Act—Overtime... Contractor that are subject to the Contract Work Hours and Safety Standards Act. (d) Payrolls and...

  8. 33 CFR 222.2 - Acquisition of lands downstream from spillways for hydrologic safety purposes.

    Science.gov (United States)

    2010-07-01

    ... CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE ENGINEERING AND DESIGN § 222.2... that would prevail without the project. General hydrologic engineering considerations are as follows...) Changes in project functions. Water resource needs within river basins change and pool levels may...

  9. 33 CFR 222.5 - Water control management (ER 1110-2-240).

    Science.gov (United States)

    2010-07-01

    ... included in the post flood reports required by ER 500-1-1, 33 CFR part 203. (n) Water Control Management... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Water control management (ER 1110... ARMY, DEPARTMENT OF DEFENSE ENGINEERING AND DESIGN § 222.5 Water control management (ER 1110-2-240)....

  10. Dosimetry of Rn-222 in the air in environments located above and below ground level

    International Nuclear Information System (INIS)

    Exposure of the general population to ionizing radiation comes mainly from natural sources. The main contribution is due to inhalation of radon (Rn-222), a gas that occurs naturally (UNSCEAR, 2000). The Rn-222 concentration in the environment is controlled by factors such as soil permeability and water content, the weather variability, materials used in the foundation and the usual positive pressure differential between the soil and the internal environment. Studies indicate that the concentration of radon shows a wide variation in the basement, ground floor and upper floors of buildings. The objective of this study is to determine radon levels in basements, ground floor and floors above ground level, at a university in the city of Sao Paulo and in one residential building in the city of Peruibe. Rn-222 measurements were performed using the method with nuclear track of solid state detectors (CR-39). The studied environments present Rn-222 concentration well below the values recommended by the International Commission on Radiological Protection, published in the 2009 document, of 300 Bq/m3 for homes and 1000 Bq/m3 for the workplace. In the residential building, the concentration of Ra-266, Th-232 and K-40 in the materials used in the building construction was also analyzed, by gamma spectrometry. The effective total dose for the resident due to external exposure was 0.8 mSv y-1, lower than the annual dose limit for the general public of 1 mSv y-1. (author)

  11. Equilibration correction of temporal measurements for sudden 222Rn concentration changes

    Science.gov (United States)

    Tan, Y.; Tokonami, S.; Liu, H.; Kearfott, K. J.

    2016-02-01

    222Rn and 220Rn can be used as tracers of groundwater or submarine springs, and 222Rn in water also could indicate indoor radon problems in some regions. The half-life of 222Rn is long enough that its concentration may remain significant during transit over relatively long distances, while that of 220Rn is not. Prior research revealed that it took about 15 min for the radon to achieve gas equilibrium at a water flow rate of 17.5 L min-1, which is approximately equivalent to the time required for the 222Rn-218Po pair to approach radioactive equilibrium and is limiting in terms of measurements of sudden radon concentration change. In this work, an algorithm is applied to improve the continuous tracing of radon concentrations in the field environment. Results of a laboratory experiment analyzed applying the analysis method illustrated its ability to allow immediate identification of sharp concentration increases. In this paper we find that a precipitous drop in radon concentrations lead to improper corrected values as the result of measurement uncertainties prior to the drop, and a method using zero instead negative values for reducing the uncertainties under such condition also is proposed.

  12. Dose assessment to inhalation exposure of indoor 222Rn daughters in Korea.

    Science.gov (United States)

    Ha, C W; Chang, S Y; Lee, B H

    1992-10-01

    Long-term, average indoor 222Rn concentrations were measured in 12 residential areas by passive CR-39 radon cups. Corresponding equilibrium-equivalent concentration of radon daughters were derived. The resulting effective dose equivalent for the Korean population due to inhalation exposure of this equilibrium-equivalent concentration of radon daughters was then evaluated.

  13. Physiological Stress Responses to Prolonged Exposure to MS-222 and Surgical Implantation in Juvenile Chinook Salmon

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Katie A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Woodley, Christa M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Seaburg, Adam [Univ. of Washington, Seattle, WA (United States); Skalski, John R. [Univ. of Washington, Seattle, WA (United States); Eppard, Matthew B. [U.S. Army Corps of Engineers, Portland, OR (United States)

    2014-07-17

    While many studies have investigated the effects of transmitters on fish condition, behavior, and survival, to our knowledge, no studies have taken into account anesthetic exposure time in addition to tag and surgery effects. We investigated stress responses to prolonged MS-222 exposure after stage 4 induction in surgically implanted juvenile Chinook salmon (Oncorhynchus tshawytscha). Survival, tag loss, plasma cortisol concentration, and blood Na+, K+, Ca2+, and pH were measured immediately following anesthetic exposure and surgical implantation and 1, 7, and 14 days post-treatment. Despite the prolonged anesthetic exposure, 3-15 minutes post Stage 4 induction, there were no mortalities or tag loss in any treatment. MS-222 was effective at delaying immediate cortisol release during surgical implantation; however, osmotic disturbances resulted, which were more pronounced in longer anesthetic time exposures. From day 1 to day 14, Na+, Ca2+, and pH significantly decreased, while cortisol significantly increased. The cortisol increase was exacerbated by surgical implantation. There was a significant interaction between MS-222 time exposure and observation day for Na+, Ca2+, K+, and pH; variations were seen in the longer time exposures, although not consistently. In conclusion, stress response patterns suggest stress associated with surgical implantation is amplified with increased exposure to MS-222.

  14. 49 CFR 173.222 - Dangerous goods in equipment, machinery or apparatus.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Dangerous goods in equipment, machinery or... Than Class 1 and Class 7 § 173.222 Dangerous goods in equipment, machinery or apparatus. Hazardous materials in machinery or apparatus are excepted from the specification packaging requirements of...

  15. Microrna-221 and microrna-222 modulate differentiation and maturation of skeletal muscle cells.

    Directory of Open Access Journals (Sweden)

    Beatrice Cardinali

    Full Text Available BACKGROUND: MicroRNAs (miRNAs are a class of small non-coding RNAs that have recently emerged as important regulators of gene expression. They negatively regulate gene expression post-transcriptionally by translational repression and target mRNA degradation. miRNAs have been shown to play crucial roles in muscle development and in regulation of muscle cell proliferation and differentiation. METHODOLOGY/PRINCIPAL FINDINGS: By comparing miRNA expression profiling of proliferating myoblasts versus differentiated myotubes, a number of modulated miRNAs, not previously implicated in regulation of myogenic differentiation, were identified. Among these, miR-221 and miR-222 were strongly down-regulated upon differentiation of both primary and established myogenic cells. Conversely, miR-221 and miR-222 expression was restored in post-mitotic, terminally differentiated myotubes subjected to Src tyrosine kinase activation. By the use of specific inhibitors we provide evidence that expression of miR-221 and miR-222 is under the control of the Ras-MAPK pathway. Both in myoblasts and in myotubes, levels of the cell cycle inhibitor p27 inversely correlated with miR-221 and miR-222 expression, and indeed we show that p27 mRNA is a direct target of these miRNAs in myogenic cells. Ectopic expression of miR-221 and miR-222 in myoblasts undergoing differentiation induced a delay in withdrawal from the cell cycle and in myogenin expression, followed by inhibition of sarcomeric protein accumulation. When miR-221 and miR-222 were expressed in myotubes undergoing maturation, a profound alteration of myofibrillar organization was observed. CONCLUSIONS/SIGNIFICANCE: miR-221 and miR-222 have been found to be modulated during myogenesis and to play a role both in the progression from myoblasts to myocytes and in the achievement of the fully differentiated phenotype. Identification of miRNAs modulating muscle gene expression is crucial for the understanding of the circuits

  16. Evaluation of the anesthetic effects of MS222 in the adult Mexican axolotl (Ambystoma mexicanum

    Directory of Open Access Journals (Sweden)

    Zullian C

    2016-01-01

    Full Text Available Chiara Zullian,1 Aurore Dodelet-Devillers,1 Stéphane Roy,2 Pascal Vachon1 1Département de Biomédecine Vétérinaire, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, 2Département de Stomatologie, Faculté de Médecine Dentaire, Montréal, Québec, Canada Abstract: The Mexican axolotl (Ambystoma mexicanum is a unique research model in several fields of medicine, where surgical and invasive procedures may be required. As yet, little is known about the efficacy of MS222 (tricaine methanesulfonate, which is the most commonly used anesthetic agent in amphibians. The main objectives of this study were to evaluate the anesthetic effects and physiological changes in adult axolotls following a 20-minute immersion bath, containing progressive MS222 concentrations starting at 0.1%. Depth of anesthesia and physiological changes were evaluated every 15 minutes post-MS222 exposure with the following parameters: righting behavior, withdrawal reflex, acetic acid test response, heart rate, and blood oxygen saturation, as well as cloacal and body surface temperatures. A 20-minute exposure in a 0.1% MS222 immersion bath (n=6 animals had no anesthetic effects on adult axolotls after 20 minutes of exposure. With a 0.2% MS222 solution, all axolotls (n=9 were deeply anesthetized at 15 minutes, and 80% were still unresponsive at 30 minutes postexposure. Blood oxygen saturation and heart rate were slightly, but significantly, increased when compared with the baseline value and remained stable up to recovery. There was no significant increase in surface and cloaca temperatures, compared with baseline. With the 0.4% MS222 solution, the duration of anesthesia lasted for 90 minutes to at least 120 minutes (n=3 animals and this concentration was deemed too high. In conclusion, a 20-minute immersion bath with 0.2% MS222 may be used for short procedures (15–30 minutes requiring anesthesia of adult axolotls. Keywords: Ambystoma mexicanum

  17. Transport of 222Rn using the regional model REMO: a detailed comparison with measurements over Europe

    International Nuclear Information System (INIS)

    The 222Rn concentration simulated by the regional atmospheric model REMO over Europe and western Siberia is compared to in-situ records in Europe, and discussed in the context of site effects for stations that are also part of a CO2 observing network. The REMO model has a limited spatial domain, forced at its lateral boundaries with meteorological fields of the European Centre for Medium-Range Weather Forecasts and with tracer concentrations issued from the TM3 global transport model. The modelled Rn field is compared to measurements at six stations: two coastal ones (Atlantic Ocean and Baltic Sea), two low-elevation sites in plains, one mountain station and one high-altitude station. We show that the synoptic and diurnal 222Rn variability as simulated by REMO (55 km by 55 km) is realistic. In some cases REMO performs better than TM3, which is of coarser resolution, but this is not always true. At Mace Head, a station located near the western edge of the REMO domain, we show that the 222Rn 'baseline' concentration is strongly influenced by boundary conditions, reflecting 222Rn transport from North America across the Atlantic Ocean. At Schauinsland, a mountain station in south-western Germany, even though the spatial resolution of REMO is not fine enough to reproduce transport processes induced by local topography, a fairly good agreement between model and measurements can be obtained, provided that one can determine from comparison of observed and modelled diurnal temperature changes which layer of the model is suitable for comparison with the data. Finally, the implications of modelling 222Rn are discussed here in the broader context of interpreting site effects that may also affect CO2 continental observations in Europe

  18. 34 CFR 222.177 - What eligibility requirements must an LEA meet to apply for an emergency grant under the first...

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What eligibility requirements must an LEA meet to apply for an emergency grant under the first priority? 222.177 Section 222.177 Education Regulations of the... the Act Eligibility § 222.177 What eligibility requirements must an LEA meet to apply for an...

  19. MicroRNA-221/222 regulate ox-LDL-induced endothelial apoptosis via Ets-1/p21 inhibition.

    Science.gov (United States)

    Qin, Bing; Cao, Yuze; Yang, Huan; Xiao, Bo; Lu, Zhengqi

    2015-07-01

    Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play an essential role in atherosclerosis. MicroRNAs (miRNAs) are a class of short non-coding RNAs, acting as posttranscriptional regulators of protein-coding genes involved in vascular cell biology. MiRNA-221 and miRNA-222 (miR-221/222) are known to be involved in the regulation of endothelial inflammation and angiogenesis. However, the function of miR-221/222 in ox-LDL-induced ECs apoptosis and atherosclerosis is still unknown. Here, we showed that miR-221/222 expression was markedly down-regulated in ox-LDL-induced apoptotic human umbilical cord vein endothelial cells. MiR-221/222 inhibition enhanced apoptosis in ECs, whereas over-expression of miR-221/222 could partly alleviate apoptotic cell death mediated by ox-LDL through suppression of Ets-1 and its downstream target p21. These findings suggest that manipulation of the miR-221/222-Ets-1-p21 pathway may offer a novel strategy for treatment of endothelial apoptosis and atherosclerosis.

  20. (222)Rn activity in groundwater of the St. Lawrence Lowlands, Quebec, eastern Canada: relation with local geology and health hazard.

    Science.gov (United States)

    Pinti, Daniele L; Retailleau, Sophie; Barnetche, Diogo; Moreira, Floriane; Moritz, Anja M; Larocque, Marie; Gélinas, Yves; Lefebvre, René; Hélie, Jean-François; Valadez, Arisai

    2014-10-01

    One hundred ninety-eight groundwater wells were sampled to measure the (222)Rn activity in the region between Montreal and Quebec City, eastern Canada. The aim of this study was to relate the spatial distribution of (222)Rn activity to the geology and the hydrogeology of the study area and to estimate the potential health risks associated with (222)Rn in the most populated area of the Province of Quebec. Most of the groundwater samples show low (222)Rn activities with a median value of 8.6 Bq/L. Ninety percent of samples show (222)Rn activity lower than 100 Bq/L, the exposure limit in groundwater recommended by the World Health Organization. A few higher (222)Rn activities (up to 310 Bq/L) have been measured in wells from the Appalachian Mountains and from the magmatic intrusion of Mont-Saint-Hilaire, known for its high level of indoor radon. The spatial distribution of (222)Rn activity seems to be related mainly to lithology differences between U-richer metasediments of the Appalachian Mountains and magmatic intrusions and the carbonaceous silty shales of the St. Lawrence Platform. Radon is slightly enriched in sodium-chlorine waters that evolved at contact with clay-rich formations. (226)Ra, the parent element of (222)Rn could be easily adsorbed on clays, creating a favorable environment for the production and release of (222)Rn into groundwater. The contribution of groundwater radon to indoor radon or by ingestion is minimal except for specific areas near Mont-Saint-Hilaire or in the Appalachian Mountains where this contribution could reach 45% of the total radioactive annual dose.

  1. Design and construction of a system for determining Radon-222 through Alpha spectroscopy; Diseno y construccion de un sistema para determinar Radon-222 mediante Espectroscopia alfa

    Energy Technology Data Exchange (ETDEWEB)

    Bonifacio, J.; Iturbe, J.L

    1992-02-15

    The study of the present work consists on designing a system to measure gas {sup 222} Rn, using a surface barrier detector, in order to obtaining a more accuracy measure of this isotope by means of an alpha particle spectra and thus to try to avoid the influence of the radioactivity of the isotope descendants of short half life, which are also emitting of alpha particles, since by other methods its should make a series of corrections to obtain the real value of the radon activity. (Author)

  2. Synthesis and Transformations of di-endo-3-Aminobicyclo-[2.2.2]oct-5-ene-2-carboxylic Acid Derivatives

    Directory of Open Access Journals (Sweden)

    Márta Palkó

    2011-09-01

    Full Text Available all-endo-3-amino-5-hydroxybicyclo[2.2.2]octane-2-carboxylic acid (13 and all-endo-5-amino-6-(hydroxymethylbicyclo[2.2.2]octan-2-ol (10 were prepared via dihydro-1,3-oxazine or g-lactone intermediates by the stereoselective functionalization of an N-protected derivative of endo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acid (2. Ring closure of b-amino ester 4 resulted in tricyclic pyrimidinones 15 and 16. The structures, stereochemistry and relative configurations of the synthesized compounds were determined by IR and NMR.

  3. The Distribution Characteristics of 222Rn and 220Rn Concentrations in Soil Gas In Zhongshan City, Guangdong Province, China

    International Nuclear Information System (INIS)

    A mapping survey of 222Rn and 220Rn concentrations in soil gas was conducted for the first time using a RAD7 portable radon monitor at 67 locations across an area of 1800 km2 in Zhongshan City (ZSC), Guangdong Province. It was found that 222Rn concentrations increased with increasing depth, whereas 220Rn concentrations were almost unchanged at different depths. The sites with high 222Rn values were located mainly in granite outcrops, while those with low values were located in a sedimentary region. The distribution patterns of 220Rn coincide with the patterns of activity concentration of 232Th in soil. (author)

  4. Relationship of 220Rn and 222Rn progeny levels in Canadian underground U mines

    International Nuclear Information System (INIS)

    Radon-222 and 220Rn progeny are found in some Canadian underground U mines. Because both can contribute to lung dose, their experimental determinations are important. The relationship between 222Rn progeny Working Level [WL(Rn)] and 220Rn progeny Working Level [WL(Tn)] has been investigated in U mines. Experimental measurements extended from 1981 to 1986 and consisted of about 700 measurements of each WL(Rn) and WL(Tn). The data were analyzed by standard linear and power-function regression analysis. A power-function relationship between WL(Rn) and WL(Tn) seemed to fit the experimental data best. The relationship obtained permits the calculation of WL(Tn) from experimental values of WL(Rn). The relationship is useful for lung-dose-calculation purposes and in mine-ventilation-engineering calculations

  5. Design and construction of a system to determine Radon-222 through alpha spectroscopy

    International Nuclear Information System (INIS)

    The purpose of this work consists in the design a radon-222 gas measurement system utilizing a surface barrier detector with the objective to obtain a more accurate measurement for this isotope through an alpha particle spectrum and so to address as to avoid the activity influence of the descendants of short half-life, which are too beta particles emitters, already other methods it must be correction series to obtain the real value of radon activity. Here are presented the general properties properties of radon, the experimental part description indicating the design to measure the radon-222 gas and its parts, as well as too the standard separation of radium-226 starting from carnotite mineral. Finally, it is presented the results obtained with a discussion about it. (Author) results obtained with a discussion about it. (Author)

  6. Metformin inhibits lung cancer cells proliferation through repressing microRNA-222.

    Science.gov (United States)

    Wang, Yuqi; Dai, Weimin; Chu, Xiangyang; Yang, Bo; Zhao, Ming; Sun, Yu'e

    2013-12-01

    Metformin, which is commonly used as an oral anti-hyperglycemic agent of the biguanide family, may reduce cancer risk and improve prognosis. However, the mechanism by which metformin affects various cancers, including lung cancer, remains unknown. MiR-222 induces cell growth and cell cycle progression via direct targeting of p27, p57 and PTEN in cancer cells. In the present study, we used A549 and NCI-H358 human lung cancer cell lines to study the effects and mechanisms of metformin. Metformin treatment reduced expression of miR-222 in these cells (p metformin. Therefore, these data provide novel evidence for a mechanism that may contribute to the anti-neoplastic effects of metformin suggested by recent population studies and justifying further work to explore potential roles for it in lung cancer treatment. PMID:23974492

  7. Low-level measurements of Ra-226/Rn-222 by pulse ionization chambers

    Science.gov (United States)

    El-Daoushy, Fand; Garcia-Tenorio, Rafael

    1988-10-01

    Characteristics of two ionization chambers have been studied and the chambers utilized for 226Ra/ 222Rn measurements for more than ten years. The results obtained show that coating of internal surfaces with a pure and thin Ag-layer enhances the background of ionization chambers in spite of some improvements at the early stages of operation. In addition to previously known parameters influencing the accuracy in routine measurements, new correction factors are suggested. 226Ra impurities in the body of ionization chambers are found to act not only as a permanent, but also as a temperature-dependent source of background. Earlier accuracies of 226Ra/ 222Rn measurements have been considerably improved by assuring long-term mechanical and thermal stability of the ionization chambers.

  8. Rn-222 tracing and stable isotope measurements of biogenic gas fluxes from methane saturated sediments

    Science.gov (United States)

    Martens, Christopher S.; Green, C. D.; Blair, Neal; Chanton, J. P.

    1985-01-01

    Transport of reduced biogenic gases from anoxic sediments and soils to the atmosphere can be quantitatively studied through measurement of radon-222/radium-226 disequilibrium. In previous work, seasonal variations in biogenic gas transport mechanisms, net fluxes and overall composition were documented. Now presented are direct field measurements of radon-222 activity in gases exiting organic rich sediments which show their usefulness for tracing of the stripping of dissolved biogenic gases from within the sediment column and transport via bubble ebullition. Methane is depleted in deuterium during the summer as compared with winter months and is in general lighter than in most marine sediments signaling the probable importance of acetate as an important precursor molecule. The significant seasonal isotopic variations observed illustrate the importance of understanding mechanisms and rates of biogenic gas production in order to interpret observed tropospheric isotopic data.

  9. Comparison of outdoor activity size distributions of {sup 220}Rn and {sup 222}Rn progeny

    Energy Technology Data Exchange (ETDEWEB)

    Mohamed, A. [Physics Department, Faculty of Science, El-Minia University (Egypt)]. E-mail: amermohamed6@hotmail.com; El-Hussein, A. [Physics Department, Faculty of Science, El-Minia University (Egypt)

    2005-06-01

    Inhalation of {sup 222}Rn and {sup 220}Rn progeny from the domestic environment contributes the greatest fraction of the natural radiation exposure to the public. Dosimetric models are most often used in the assessment of human lung doses due to inhaled radioactivity because of the difficulty in making direct measurements. These models require information about the parameters of activity size distributions of thoron and radon progeny. The present study presents measured data on the attached and unattached activity size distributions of thoron and radon progeny in outdoor air in El-Minia, Egypt. The attached fraction was collected using a low-pressure Berner cascade impactor technique. A screen diffusion battery was used for collecting the unattached fraction. Most of the attached activities for {sup 222}Rn and {sup 220}Rn progeny were associated with aerosol particles of the accumulation mode. The activity size distribution of thoron progeny was found to be shifted to slightly smaller particle size compared to radon progeny.

  10. Fate of 2,2,2-trichloroacetaldehyde (chloral hydrate) produced during trichloroethylene oxidation by methanotrophs.

    OpenAIRE

    Newman, L M; Wackett, L P

    1991-01-01

    Four different methanotrophs expressing soluble methane monooxygenase produced 2,2,2-trichloroacetaldehyde, or chloral hydrate, a controlled substance, during the oxidation of trichloroethylene. Chloral hydrate concentrations decreased in these cultures between 1 h and 24 h of incubation. Chloral hydrate was shown to be biologically transformed to trichloroethanol and trichloroacetic acid by Methylosinus trichosporium OB3b. At elevated pH and temperature, chloral hydrate readily decomposed an...

  11. Detection of Solar Rotational Variability in the LYRA 190 - 222 nm Spectral Band

    OpenAIRE

    Shapiro, A. V.; Shapiro, A. I.; Dominique, M.; Dammasch, I. E.; Wehrli, C.; Rozanov, E.; Schmutz, W.

    2012-01-01

    We analyze the variability of the spectral solar irradiance during the period from 7 January, 2010 until 20 January, 2010 as measured by the Herzberg channel (190-222 nm) of the Large Yield RAdiometer (LYRA) onboard PROBA2. In this period of time observations by the LYRA nominal unit experienced degradation and the signal produced by the Herzberg channel frequently jumped from one level to another. Both these factors significantly complicates the analysis. We present the algorithm which allow...

  12. Investigation of radon-222 in subsurface waters as an earthquake predictor

    International Nuclear Information System (INIS)

    Changes of radon-222 content of well waters in seismically active regions may provide earthquake precursor signals, according to reports of recent Chinese and Russian work. A high-precision γ-ray system for continuous monitoring of radon in wells and springs has been developed at the Lawrence Berkeley Laboratory, where monitoring began in April 1975, and has been extended to other sites including the San Andreas fault zone

  13. Measurements of indoor 222RN activity in dwellings and workplaces of Curitiba (Brazil)

    Science.gov (United States)

    Corrêa, Janine N.; Paschuk, Sergei A.; Del Claro, Flávia; Kappke, Jaqueline; Perna, Allan F. N.; Schelin, Hugo R.; Denyak, Valeriy

    2014-11-01

    The present work describes the results of systematic measurements of radon (222Rn) in residential environments and workplaces in the Metropolitan Region of Curitiba (Paraná State, Brazil) during the period 2004-2012. For radon in air activity measurements, polycarbonate Track Etch Detectors CR-39, mounted in diffusion chambers protected by borosilicate glass fiber filters, were used. After being exposed in air, the CR-39 detectors were submitted to a chemical etching in a 6.25 M NaOH solution at 70 °C for 14 h. The alpha particle tracks were identified and manually counted with an optical microscope, and with the results of previously performed calibrations, the indoor activity concentration of 222Rn was calculated. The calibration of CR-39 and the alpha particle tracks chemical development procedures were performed in collaboration the National Institute of Radiological Sciences (NIRS, Japan). The major part of indoor 222Rn concentration in residences was found to be below 100 Bq/m3. In the case of working places, all measurements of 222Rn concentrations were below 100 Bq/m3. These values are considered within the limits set by international regulatory agencies, such as the US EPA and ICRP, which adopt up to 148 and 300 Bq/m3 as upper values for the reference levels for radon gas activity in dwellings, respectively. The latest value of 300 Bq/m3 for radon activity in air is proposed by ICRP considering the upper value for the individual dose reference level for radon exposure of 10 mSv/yr.

  14. Measurements of 222Rn and220Rn with a large size collector of radon progeny

    International Nuclear Information System (INIS)

    People have paid more attention to radon since 1980s. Radon concentrations in high background radiation areas in the south are higher than others in China, especially 220 Rn concentration is significantly high. Therefore, measurement of 222 Rn and 220 Rn concentration should be carried out there. I will introduce a large size collector of radon progeny and its applications in this paper. The collector is a sheet of polyvinyl chloride fibre with electrostatics of -500V ∼ -700V. Its size (60mm in diameter) is larger than others (26mm in diameter) that work as the same principle. The collector is more effective to adsorb radon progeny than most of others. The equipment of ZnS(Ag) Scintillation Counting System is available for large size collectors to detect radon progeny. Therefore its sensitivity of measurement is high than others. According to the different half life of radon progeny and based on both theory and experiment, a formula for discrimination and calculation of 222 Rn and 220 Rn concentrations was deduced. The 222 Rn and 220 Rn concentrations were surveyed with electrostatic collectors of radon progeny on the campus of commercial school and some other areas in Hainan, southern China. Neither 222 Rn nor 220 Rn concentrations were found significant high. However several faults underground were delineated. The collector is also used to study radon transportation. Results indicate that radon changes regularly with date when it has transported for a certain distance. Velocities of radon migration in the four media are quite different. Radon migrates more quickly in vertical tube than in the horizontal tube

  15. Indoor 222Rn and 220Rn variations as an evidence for Boyle's law

    International Nuclear Information System (INIS)

    The 222Rn and 220Rn levels were measured for Bangalore Metropolitan, India was focused on various types of houses with respect to ventilation characteristics. Dimension of room was taken into account to correlate the air rate the virtue of number of windows and ventilation openings. Integrated and long-term measurements of radon were carried out in the dwellings using twin cup dosimeters with Solid State Nuclear Track Detector. Result shows that the concentration exponentially with the increase in room volume. (author)

  16. [2+2+2] cycloaddition reactions involving allenes catalysed by rhodium

    OpenAIRE

    Haraburda, Ewelina

    2015-01-01

    The development of new chemical processes for the formation of carbon-carbon bonds is an important topic in organic chemistry. In particular, the transition metal catalysed [2+2+2] cycloaddition reaction is a highly efficient synthetic tool that allows six-membered polysubstituted carbo- and heterocyclic derivatives to be obtained in an atom economy process. Allenes are versatile substrates for cycloaddition reactions that provide a good reactivity profile together with the ability to increas...

  17. Measurements of 222Rn and 220Rn with a Large Size Collector of Radon Progeny

    Institute of Scientific and Technical Information of China (English)

    Wu Qifan; Jia Wenyi; Fang Fang; Wang Jun; Cheng Jianping; Liu Guilin; Zhu Li

    2003-01-01

    Radon concentrations in high background radiation areas in the south are higher than those of others in China, especially 220Rn concentration is significantly high. Therefore, measurements of 222Rn and 220 Rn concentrations should be carried out there. This paper introduces a large size collector of radon progeny and its applications. The collector is a sheet of polyvinyl chloride fiber with electrostatics of (-500 V) - ( -700 V). Its size (60 mm in diameter) is larger than those of others (26 mm in diameter) that work with the same principle. The collector is more effective to adsorb radon progeny than most of others. The equipment of ZnS(Ag) Scintillation Counting System is available for large size collectors to detect radon progeny. Therefore, its sensitivity of measurement is higher than that of others.According to the different half lives of radon progeny, and based on both theory and experiments, a formula for discrimination and calculation of 222 Rn and 220Rn concentrations is deduced. The 222Rn and 220Rn concentrations were surveyed with electrostatic collectors of radon progeny on the campus of com-mercial school and some other areas in Hainan, southern China. Neither 222Rn nor 220Rn concentration was found significantly high. However, several faults underground were delineated. The collector is also used to study radon transportation. Results indicate that radon changes regularly with date when it has transported for a certain distance. Velocities of radon migration in the four media are quite different.Radon migrates more quickly in vertical tube than in the horizontal tube.

  18. Investigation of natural levels of radon-222 in groundwater in Maine for assessment of related health effects

    International Nuclear Information System (INIS)

    We have used an inexpensive radon (222Rn) measurement method using liquid scintillation counting to remeasure potable water from 10 sites near Raymond, Maine, to determine the accuracy and reproducibility of earlier measurements. Duplication or triplication of samples shows a high degree of reproducibility for the liquid scintillation method. A hypothesis emerged from analysis of the measured values of 222Rn near Raymond, Maine, that high values (50,000 to 200,000 pCi/liter) are associated with granite. This was shown to be correct for several large areas of granite such as the Sebago, Lucern, Waldo, and Waldoboro granites. The presence of high 222Rn concentrations in granite areas hundreds of kilometers from the Raymond area shows that the high 222Rn levels in water are a statewide and perhaps a regional problem rather than a western Maine problem

  19. The diurnal evolution of 222Rn and its progeny in the atmospheric boundary layer during the Wangara experiment

    Directory of Open Access Journals (Sweden)

    S. Galmarini

    2007-06-01

    Full Text Available The diurnal atmospheric boundary layer evolution of the 222Rn decaying family is studied by using a state-of-the-art large-eddy simulation model. In particular, a diurnal cycle observed during the Wangara experiment is successfully simulated together with the effect of diurnal varying turbulent characteristics on radioactive compounds in a secular equilibrium. This study allows us to clearly analyze and identify the boundary layer processes driving the 222Rn and its progeny concentration behaviors. The activity disequilibrium observed in the nocturnal boundary layer is due to the proximity of the radon source and the trapping of fresh 222Rn close to the surface induced by the weak vertical transport. During the morning transition, the secular equilibrium is fast restored by the vigorous turbulent mixing. The evolution of 222Rn and its progeny concentration in the unsteady growing convective boundary layer depends on the strength of entrainment events.

  20. 77 FR 29682 - Gulf of Mexico, Outer Continental Shelf, Central Planning Area, Oil and Gas Lease Sale 216/222

    Science.gov (United States)

    2012-05-18

    ... Availability (NOA) of a Record of Decision (ROD) on a Final Supplemental Environmental Impact Statement (SEIS... Area (CPA) Lease Sale 216/222 Authority: This NOA is published pursuant to the regulations (40 CFR...

  1. Effects of air conditioning, dehumidification and natural ventilation on indoor concentrations of {sup 222}Rn and {sup 220}Rn

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Thomas K.C.; Yu, K.N. E-mail: peter.yu@cityu.edu.hk

    2000-01-01

    A bedroom was selected for detailed measurements on {sup 220}Rn and {sup 222}Rn concentrations and environmental parameters including CO{sub 2} concentration, temperature and relative humidity. To simulate different sealing conditions, five conditions were artificially created in the sampling period of 25 consecutive days. It was concluded that natural ventilation is the most efficient way to lower the {sup 222}Rn levels, while air conditioning is the next. Dehumidification provides only a marginal reduction of {sup 222}Rn levels. The {sup 220}Rn concentrations are not affected by natural ventilation, air conditioner or dehumidification, and were all around 10 Bq m{sup -3}. There are no significant correlations between the {sup 220}Rn and {sup 222}Rn concentrations and environmental conditions such as CO{sub 2} concentrations, temperature, relative humidity and pressure.

  2. Environmental effects on 222Rn fluence rate from reclaimed uranium mill tailings

    International Nuclear Information System (INIS)

    The author measured 222Rn fluence rate from 2 plots with uranium mill tailings buried beneath 30 cm of overburden and 30 cm of topsoil. An additional 30 cm of clay covered the tailings on 1 of the plots and each plot was subdivided into bare soil and vegetated subplots. The author also measured a control plot, identical to the plot without a clay cap but having no tailings. In addition to fluence rate, The author measured moisture in each of the plot layers, atmospheric pressure, air temperature and relative humidity during each sampling period. The author used linear correlation, two-way ANOVA and stepwise multiple regression to analyze the effects of the plot characteristics and the environmental variables on 222Rn fluence rate. The mean fluence rate from the plot having both a clay cap and a vegetated surface was over 3 times that of the vegetated plot without a clay cap and 14 times that of the bare plot with a clay cap. The interaction effect may be due to the proliferation of roots in the moist clay and active transport of dissolved 222Rn to the surface in water

  3. Measurements of 222Rn activity concentration in domestic water sources in Penang, northern peninsular Malaysia.

    Science.gov (United States)

    Muhammad, B G; Jaafar, M S; Azhar, A R; Akpa, T C

    2012-04-01

    Measurements of (222)Rn activity concentration were carried out in 39 samples collected from the domestic and drinking water sources used in the island and mainland of Penang, northern peninsular, Malaysia. The measured activity concentrations ranged from 7.49 to 26.25 Bq l(-1), 0.49 to 9.72 Bq l(-1) and 0.58 to 2.54 Bq l(-1) in the raw, treated and bottled water samples collected, respectively. This indicated relatively high radon concentrations compared with that from other parts of the world, which still falls below the WHO recommended treatment level of 100 Bq l(-1). From this data, the age-dependent associated committed effective doses due to the ingestion of (222)Rn as a consequence of direct consumption of drinking water were calculated. The committed effective doses from (222)Rn resulting from 1 y's consumption of these water were estimated to range from 0.003 to 0.048, 0.001 to 0.018 and 0.002 to 0.023 mSv y(-1), for age groups 0-1, 2-16 and >16 y, respectively.

  4. Study on {sup 222-226}Th isotopes in the cranking framework

    Energy Technology Data Exchange (ETDEWEB)

    Ram, Daya; Devi, Rani; Khosa, S.K., E-mail: rani_rakwal@yahoo.co.in [Department of Physics and Electronics, University of Jammu, Jammu and Kashmir (India)

    2013-08-15

    The yrast spectra, quadrupole moments, quadrupole deformation parameters (β{sub 2}), non-axiality parameters (γ), root mean-square radii for protons and neutrons, occupation probabilities, moment of inertia (I), and B(E2) transition probabilities are calculated for {sup 222{sup -226}}Th in the cranked Hartree-Bogoliubov framework. The calculations employ a quadrupole-quadrupole plus pairing model of residual interaction operating in a reasonably large valence space outside the {sup 164}Pb core. Our calculations reproduce qualitatively the observed yrast spectra in {sup 222-226}Th up to spin 20{sup +}. The calculated results indicate that the non-axiality parameter decreases as one moves along the yrast states. The observed increase in deformation from {sup 222}Th to {sup 226}Th is due to the increase in the occupation of low-κ components of (2g{sub 9/2}){sub π} and (1{sub j15/2}){sub ν} orbits. The model parameters reproduce not only the moment of inertia, deformation, and transition probabilities but also the proton and neutron pairing gaps and are the most appropriate for cranking studies in this region. (author)

  5. Radon-222 exhalation from Danish building materials: H + H Industri A/S results

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, C.E

    1999-08-01

    This report describes a closed-chamber method for laboratory measurements of the rate at which radon-222 degasses (exhales) from small building material samples. The chamber is 55 L in volume and the main sample geometry is a slab of dimensions 5x30x30 cm{sup 3} . Numerical modelling is used to assess (and partly remove) the bias of the method relative to an ideal measurement of the free exhalation rate. Experimental results obtained with the method are found to be in agreement with the results of an open-chamber method (which is subject to different sources of error). Results of radon-222 exhalation rate measurements for 10 samples of Danish building materials are reported. Samples include ordinary concrete, lightweight aggregate concrete, autoclaved aerated concrete, bricks, and gypsum board. The maximum mass-specific exhalation rate is about 20 mBq h{sup -1} kg{sup -1}. Under consideration of the specific applications of the investigated building materials, the contribution to the indoor radon-222 concentration in a single-family reference house is calculated. Numerical modelling is used to help extrapolate the laboratory measurements on small samples to full scale walls. Application of typical materials will increase the indoor concentration by less than 10 Bq m{sup -3}. (au) 6 tabs., 15 ills., 29 refs.

  6. Measurements of the radon-222 concentration in residences of Lima - Peru

    International Nuclear Information System (INIS)

    The measurement of the Radon-222 levels was realized in the first semester of 2013 in residences corresponding to 16 districts of the metropolitan area of Lima, including to the zones North, Center and South of the city, during one period of 3 to 6 months in continuous form, with measurement periods of 1 to 2 months. The houses where the measurements were made were selected considering diverse variables as antiquity, construction materials, coatings, soil type, occupational use of the monitored rooms, etc. The measurements were realized in basements, first and second floor of the residences. For the Radon-222 measurements passive detectors of cellulose nitrate (Lr-115) were used. The procedure of data collection, dosimeters reading and the measurement results are shown in this work; this monitoring is the first one that is carried out in this city. The results are only indicators of the present radon rate, by the detectors type not is possible to discriminate the presence of the Radon-222 descendants. (Author)

  7. Radon-222 signatures of natural ventilation regimes in an underground quarry.

    Science.gov (United States)

    Perrier, Frédéric; Richon, Patrick; Crouzeix, Catherine; Morat, Pierre; Le Mouël, Jean Louis

    2004-01-01

    Radon-222 activity concentration has been monitored since 1999 in an underground limestone quarry located in Vincennes, near Paris, France. It is homogeneous in summer, with an average value of 1700 Bq m(-3), and varies from 730 to 1450 Bq m(-3) in winter, indicating natural ventilation with a rate ranging from 0.5 to 2.4 x 10(-6) s(-1) (0.04-0.22 day(-1)). This hypothesis is supported by measurements in the vertical access pit where, in winter, a turbulent air current produces a stable radon profile, smoothly decreasing from 700 Bq m(-3) at 20 m depth to 300 Bq m(-3) at surface. In summer, a thermal stratification is maintained in the pit, but the radon-222 concentration jumps repeatedly between 100 and 2000 Bq m(-3). These jumps are due to atmospheric pressure pumping, which induces ventilation in the quarry at a rate of about 0.1 x 10(-6) s(-1) (0.009 day(-1)). Radon-222 monitoring thus provides a dynamical characterisation of ventilation regimes, which is important for the assessment of the long-term evolution of underground systems.

  8. Determination of {sup 222}Rn in groundwater - Recent applications for the investigation of river bank infiltration

    Energy Technology Data Exchange (ETDEWEB)

    Freyer, K.; Treutler, H.C. [Leipzig-Halle Ltd, Permoserstr, Leipzig (Germany). Centre for Environmental Research; Dehnert, J.; Nestler, W. [Hochschule fuer Technik und Wirtschaft Dresrden, Dresden (Germany)

    1997-10-01

    With a half life of 3.8 days, the {sup 222}Rn found in all groundwater makes an excellent tracer for solving several problems in the field of environmental research and hydrology. In Germany alluvial aquifers connected to rivers are used for drinking water extraction. Consequently importance is attached to studying the exchange processes between surface water and groundwater in order to determine infiltration velocities and infiltrate retention times in the aquifer. However, such investigations require a reliable, reproducible method for determining radon activity concentrations in groundwater samples, as well as a suitable sampling technique. This paper reports on just such a method, containing detailed instructions for sampling, transportation and activity determination using liquid scintillation spectrometry following toluene extraction. Spectral analysis and {alpha}/{beta} separation improve the accuracy of measurement. The detection limit is about 0.05 Bq/1; the total error is <{+-}10%. Infiltration processes are studied with {sup 222}Rn by employing the effect that surface water infiltrating an aquifer absorbs {sup 222}Rn along the infiltration pathway. As the degree of uptake is a function of the retention time, flow paths and flow velocities can all be determined by measuring the radon activity concentrations at the various groundwater gauging stations along measuring profiles. Corresponding investigations were carried out into a pleistocene aquifer below the River Elbe near a waterworks extracting bank-filtered water. The findings are presented and the technique`s possibilities and limitations are discussed 12 refs., 3 figs.

  9. Measurements of 222Rn activity concentration in domestic water sources in Penang, northern peninsular Malaysia.

    Science.gov (United States)

    Muhammad, B G; Jaafar, M S; Azhar, A R; Akpa, T C

    2012-04-01

    Measurements of (222)Rn activity concentration were carried out in 39 samples collected from the domestic and drinking water sources used in the island and mainland of Penang, northern peninsular, Malaysia. The measured activity concentrations ranged from 7.49 to 26.25 Bq l(-1), 0.49 to 9.72 Bq l(-1) and 0.58 to 2.54 Bq l(-1) in the raw, treated and bottled water samples collected, respectively. This indicated relatively high radon concentrations compared with that from other parts of the world, which still falls below the WHO recommended treatment level of 100 Bq l(-1). From this data, the age-dependent associated committed effective doses due to the ingestion of (222)Rn as a consequence of direct consumption of drinking water were calculated. The committed effective doses from (222)Rn resulting from 1 y's consumption of these water were estimated to range from 0.003 to 0.048, 0.001 to 0.018 and 0.002 to 0.023 mSv y(-1), for age groups 0-1, 2-16 and >16 y, respectively. PMID:21642647

  10. Measurements of soil and canopy exchange rates in the Amazon rain forest using Rn-222

    Science.gov (United States)

    Trumbore, S. E.; Keller, M.; Wofsy, S. C.; Da Costa, J. M.

    1990-01-01

    Measurements were taken of the emission of Rn-222 from Amazon forest rocks and soils and used as a tracer of ventilation of the forest canopy layer at night. It was determined that the greatest resistance to transfer of trace gases from the soil to the atmosphere lies in the soil air space. Profiles of Rn-222 and CO2 showed steepest concentration gradients in the layer between 0 and 3 m above soil surface. Aerodynamic resistances calculated for this layer from Rn-222 and CO2 varied from 1.6 to 18 s/cm, with greater resistance during the afternoon than at night. The resistance to exchange with air from the entire 41 m layer below the canopy averaged 4.8 s/cm during 13 nights of CO2 profiles. The calculated average time to flush the layer below 41 m is 5.5 hr, and it is concluded that this indicates that significant exchange occurs despite nocturnal stratification.

  11. Primary investigation and study on 222Rn and 220Rn levels of underground coal mines in China

    International Nuclear Information System (INIS)

    From Dec. of 2002 to Aug. of 2004, by using Solid State Nuclear Track Detectors (SSNTDs), the 222Rn concentrations of 8 underground coal mines, i.e., Beijing Shijiaying, Beijing Fangshanchengguan, Shanxi Gujiaoxiqu, Shanxi Taiyuan Wangfang, Hunan Baifang, Hunan Songbai, Guizhou Honglin and Zhejiang Anrenjinjiang, Respectively, had been measured during a period of 12 months (once a three-month). The surveyed data showed that the annual average 222Rn concentrations (with number of measuring points) are 550(69), 3187(28), 45(224), 117(72), 88(79), 79(58), 40(72) and 136(116) Bq/m3, respectively. The 222Rn concentrations of underground coal mines vary with ventilation condition, geological structure and other factors, and the 222Rn concentration in the mine with bad ventilation is generally high, and varies with seasons i.e., higher in summer and autumn and lower in winter. The 222Rn concentration in mines with good ventilation is generally low and no notable variation with the season. These are also some characters of 222Rn levels in Chinese coal mines, such as the 222Rn concentrations in state-run coal mines are general low, but those in Beijing area are very high, and those in Zhejiang rock coal mines are not so high as expected, etc., the possible reasons have been discussed in the paper. The 220Rn levels of 4 coal mines in Beijing and Hunan were also measured, the ratios of alpha potential energy concentration of 220Rn daughters to that of 222Rn daughters are between 0.036 and 0.42. (authors)

  12. Numerical simulation of {sup 222}RN exhalation from phosphogypsum building blocks and accumulation inside a closed chamber

    Energy Technology Data Exchange (ETDEWEB)

    Rabi Junior, Jose A. [Sao Paulo Univ., Pirassununga, SP (Brazil). Faculdade de Zootecnia e Engenharia de Alimentos]. E-mail: jrabi@fzea.usp.br; Silva, Nivaldo C. da [Pontificia Univ. Catolica de Minas Gerais, Pocos de Caldas, MG (Brazil)]|[Comissao Nacional de Energia Nuclear (CNEN), Pocos de Caldas, MG (Brazil). Laboratorio]. E-mail: ncsilva@pucpcaldas.br; ncsilva@cnen.gov.br

    2005-07-01

    Zero-order models for {sup 222}Rn exhalation from phosphogypsum-bearing building materials and its transient indoor accumulation assume uniform distribution inside the enclosure. Conversely, this paper numerically simulates a transient two-dimensional {sup 222}Rn accumulation in a test chamber that contains a phosphogypsum board at one wall. Results show that above hypothesis might be oversimplified when spatial dependence is considered. (author)

  13. The Inhibition of the Highly Expressed Mir-221 and Mir-222 Impairs the Growth of Prostate Carcinoma Xenografts in Mice

    Science.gov (United States)

    Mercatelli, Neri; Coppola, Valeria; Bonci, Desirée; Miele, Francesca; Costantini, Arianna; Guadagnoli, Marco; Bonanno, Elena; Muto, Giovanni; Frajese, Giovanni Vanni; De Maria, Ruggero; Spagnoli, Luigi Giusto; Farace, Maria Giulia; Ciafrè, Silvia Anna

    2008-01-01

    Background MiR-221 and miR-222 are two highly homologous microRNAs whose upregulation has been recently described in several types of human tumors, for some of which their oncogenic role was explained by the discovery of their target p27, a key cell cycle regulator. We previously showed this regulatory relationship in prostate carcinoma cell lines in vitro, underlying the role of miR-221/222 as inducers of proliferation and tumorigenicity. Methodology/Principal Findings Here we describe a number of in vivo approaches confirming our previous data. The ectopic overexpression of miR-221 is able, per se, to confer a high growth advantage to LNCaP-derived tumors in SCID mice. Consistently, the anti-miR-221/222 antagomir treatment of established subcutaneous tumors derived from the highly aggressive PC3 cell line, naturally expressing high levels of miR-221/222, reduces tumor growth by increasing intratumoral p27 amount; this effect is long lasting, as it is detectable as long as 25 days after the treatment. Furthermore, we provide evidence in favour of a clinical relevance of the role of miR-221/222 in prostate carcinoma, by showing their general upregulation in patient-derived primary cell lines, where we find a significant inverse correlation with p27 expression. Conclusions/Significance These findings suggest that modulating miR-221/222 levels may have a therapeutic potential in prostate carcinoma. PMID:19107213

  14. Estimated average annual radon-222 concentrations around the former uranium mill site in Shiprock, New Mexico. Final technical note

    International Nuclear Information System (INIS)

    Uranium mills, as a part of the nuclear fuel cycle, produce large volumes of wastes which contain both the long and short-lived radionuclides from the naturally-occurring uranium decay chain. A relatively short-lived member of the chain, radon-222, is a noble gas and can diffuse from the wastes and be transported from its point of origin by prevailing winds. The airborne radon-222 decays into other short-lived radioactive progeny which may result in human inhalation exposures at considerable distances from the point of origin. Since the parent of radon-222 has a half-life of 1620 years, exposure to radon and its progeny will persist for thousands of years. This study was made to estimate the annual average radon-222 concentrations around the former Shiprock, New Mexico uranium mill site in order to identify areas which may require limited or restricted occupancy and to evaluate the effectiveness of the site decontamination activities in reducing the ambient airborne radon-222 concentrations. Using on- and off-site meteorological data and radon source term estimations, average annual radon-222 isoconcentration lines were determined by computer modeling for the mill site area. The lines were determined for both pre- and post-decontamination periods

  15. Estimation of the radiological risk related to the presence of radon 222 in a hydrotherapy centre in Tunisia

    Energy Technology Data Exchange (ETDEWEB)

    Labidi, S [Institut Superieur des Technologies Medicales de Tunis (Tunisia); Essafi, F [Faculte de Medecine de Tunis, Section de Biophysique, Tunis (Tunisia); Mahjoubi, H [Institut Superieur des Technologies Medicales de Tunis (Tunisia)

    2006-09-15

    The {sup 222}Rn concentration in air was measured in a thermal water spa used as a hydrotherapy centre in Tunisia. The associated health risk for employees and patients due to the inhalation of {sup 222}Rn and its progeny was estimated. A protection scheme for the employees of the spas has been designed. Results show that the {sup 222}Rn concentration varies in the range 33-589 Bq m{sup -3}. The {sup 222}Rn concentrations measured in the present study show lower values in comparison to those reported for thermal spas in other countries. The {sup 222}Rn concentration in different rooms of the spa depends mainly on the ventilation rate. A model based on a dosimetric approach was adopted to estimate the radon risk considering the {sup 222}Rn concentration, the time spent in the spa, and the radioactive equilibrium factor F. The annual effective dose was found to vary between 0.2 and 1.7 mSv for workers while the range for patients was from 2.8 x 10{sup -4} to 1.1 x 10{sup -4} mSv. These values are within the ICRP recommended values. (note)

  16. {sup 222}Rn and {sup 220}Rn concentrations in soil gas of Karkonosze-Izera Block (Sudetes, Poland)

    Energy Technology Data Exchange (ETDEWEB)

    Malczewski, Dariusz [Faculty of Earth Sciences, University of Silesia, Bedzinska 60, 41-200 Sosnowiec, Silesia (Poland)]. E-mail: malczews@us.edu.pl; Zaba, Jerzy [Faculty of Earth Sciences, University of Silesia, Bedzinska 60, 41-200 Sosnowiec, Silesia (Poland)]. E-mail: jzaba@interia.pl

    2007-07-01

    Soil gas {sup 222}Rn and {sup 220}Rn concentrations were measured at 18 locations in the Karkonosze-Izera Block area in southwestern Poland. Measurements were carried out in surface air and at sampling depths of 10, 40 and 80 cm. Surface air {sup 222}Rn concentrations ranged from 4 to 2160 Bq m{sup -3} and {sup 220}Rn ranged from 4 to 228 Bq m{sup -3}. The concentrations for 10 and 40 cm varied from 142 Bq m{sup -3} to 801 kBq m{sup -3} and 102 Bq m{sup -3} to 64 kBq m{sup -3} for {sup 222}Rn and {sup 220}Rn, respectively. At 80 cm {sup 222}Rn concentrations ranged from 94 Bq m{sup -3} to >1 MBq m{sup -3}. The {sup 220}Rn concentrations at 80 cm varied from 45 Bq m{sup -3} to 48 kBq m{sup -3}. The concentration versus depth profiles for {sup 222}Rn differed for soils developed on fault zones, uranium deposits or both. Atmospheric air temperature and soil gas {sup 222}Rn and {sup 220}Rn were negatively correlated. At sampling sites with steep slopes, {sup 220}Rn concentrations decreased with depth.

  17. MS-222对大菱鲆麻醉效果及富集消除规律研究%Anesthesia effects and accumulation and elimination regularity of MS-222 in turbotScophthalmus maxinus

    Institute of Scientific and Technical Information of China (English)

    孙伟红; 赵东豪; 付树林; 邢丽红; 冷凯良; 朱敏

    2015-01-01

    目的:确立大菱鲆的有效麻醉浓度,研究3-氨基苯甲酸乙酯甲基磺酸盐(MS-222)在大菱鲆体内的生物富集和消除规律。方法考察大菱鲆在不同MS-222浓度下麻醉、苏醒过程中的行为变化以及呼吸频率的变化,采用液相色谱-串联质谱法测定大菱鲆组织中的药物水平。结果 MS-222麻醉大菱鲆的有效浓度为60 mg/L,在此浓度下,鱼体能够在5 min之内达到第IV期麻醉状态,5 min之内苏醒恢复。大菱鲆肝脏中MS-222的富集浓度高于肌肉,经48 h消除实验后肌肉和肝脏中的MS-222均低于1μg/kg,其消除半衰期分别为13.14 h(肌肉)和14.15 h(肝脏)。结论在水温不低于(12±0.3)℃条件下,建议将MS-222的休药期定为3天。%ABSTRACT:Objective Toestablish effective anesthesia concentrations and study the regularity of accu-mulation and elimination of tricaine methanesulfonate (MS-222) in muscle and liver of turbot. Methods Under different concentrations of MS-222 anesthesia, waking up in the process of behavior change and the change of respiratory frequency were studied in turbot. The residues were detected by liquid chromatogra-phy-tandem mass spectrometry (LC-MS/MS).ResultsThe effective concentration of MS-222 for turbot was 60 mg/L, and under this condition, it reached stage IV anesthesia and recovered within 5 min. The ac-cumulation amount of turbot liver was higher than that of the muscle. The MS-222 concentration was elimi-nated below safe quantity (1μg/kg) in muscle and liver after 48 h, and the elimination half-life were 13.14 h (muscle) and 14.15 h (liver).ConclusionUnder the condition of this experiment, it was recommended withdrawal period of 3 d.

  18. miR-221/222 Promotes S-Phase Entry and Cellular Migration in Control of Basal-Like Breast Cancer

    Directory of Open Access Journals (Sweden)

    Yuan Li

    2014-05-01

    Full Text Available The miR-221/222 cluster has been demonstrated to function as oncomiR in human cancers. miR-221/222 promotes epithelial-to-mesenchymal transition (EMT and confers tamoxifen resistance in breast cancer. However, the effects and mechanisms by which miR-221/222 regulates breast cancer aggressiveness remain unclear. Here we detected a much higher expression of miR-221/222 in highly invasive basal-like breast cancer (BLBC cells than that in non-invasive luminal cells. A microRNA dataset from breast cancer patients indicated an elevated expression of miR-221/222 in BLBC subtype. S-phase entry of the cell cycle was associated with the induction of miR-221/222 expression. miRNA inhibitors specially targeting miR-221 or miR-222 both significantly suppressed cellular migration, invasion and G1/S transition of the cell cycle in BLBC cell types. Proteomic analysis demonstrated the down-regulation of two tumor suppressor genes, suppressor of cytokine signaling 1 (SOCS1 and cyclin-dependent kinase inhibit 1B (CDKN1B, by miR-221/222. This is the first report to reveal miR-221/222 regulation of G1/S transition of the cell cycle. These findings demonstrate that miR-221/222 contribute to the aggressiveness in control of BLBC.

  19. Advance research on microRNA-221,microRNA-222 and malignant tumor%microRNA-221和microRNA-222与恶性肿瘤的研究进展

    Institute of Scientific and Technical Information of China (English)

    张春智; 康春生; 浦佩玉

    2009-01-01

    It has become clear that particular microRNAs(miRNAs) function either as tumor suppres-sors or oncogenes, whose loss or overexpression, respectively, has diagnostic and prognostic significance.Mi-croRNA-221 and microRNA-222 are a cluster microRNAs of oncogenes.They are overexpressed in some malig-nant tumors, including glioblstoma, prostate carcinoma, papillary thyroid carcinoma, and so on.By regulating particular target mRNAs, microRNA-221 and microRNA-222 perform pro- oneogenie role.p27kip1 and p57kip2 are target genes of microRNA-221 and mieroRNA-222.MicroRNA-221 and microRNA-222 promote oncogensis and tumor grow by down-regulating p27kip1 and p57kip2 expression.%微RNA(micmRNA)-221和microRNA-222是成簇的microRNA,在恶性肿瘤中起促癌作用,在胶质母细胞瘤、前列腺癌、乳头状甲状腺癌等恶性肿瘤中高表达.microRNA-221和microRNA-222通过调控其特定的靶基因行使促癌作用.在所有预测的靶基因中,p27kip1和p57kip2是已被验证的靶基因,microRNA-221和microRNA-222通过下调p27kip1和p57kip2的表达来促进肿瘤的形成和生长.

  20. Efficacy of tricaine methanesulfonate (MS-222 as an anesthetic agent for blocking sensory-motor responses in Xenopus laevis tadpoles.

    Directory of Open Access Journals (Sweden)

    Carlana Ramlochansingh

    Full Text Available Anesthetics are drugs that reversibly relieve pain, decrease body movements and suppress neuronal activity. Most drugs only cover one of these effects; for instance, analgesics relieve pain but fail to block primary fiber responses to noxious stimuli. Alternately, paralytic drugs block synaptic transmission at neuromuscular junctions, thereby effectively paralyzing skeletal muscles. Thus, both analgesics and paralytics each accomplish one effect, but fail to singularly account for all three. Tricaine methanesulfonate (MS-222 is structurally similar to benzocaine, a typical anesthetic for anamniote vertebrates, but contains a sulfate moiety rendering this drug more hydrophilic. MS-222 is used as anesthetic in poikilothermic animals such as fish and amphibians. However, it is often argued that MS-222 is only a hypnotic drug and its ability to block neural activity has been questioned. This prompted us to evaluate the potency and dynamics of MS-222-induced effects on neuronal firing of sensory and motor nerves alongside a defined motor behavior in semi-intact in vitro preparations of Xenopus laevis tadpoles. Electrophysiological recordings of extraocular motor discharge and both spontaneous and evoked mechanosensory nerve activity were measured before, during and after administration of MS-222, then compared to benzocaine and a known paralytic, pancuronium. Both MS-222 and benzocaine, but not pancuronium caused a dose-dependent, reversible blockade of extraocular motor and sensory nerve activity. These results indicate that MS-222 as benzocaine blocks the activity of both sensory and motor nerves compatible with the mechanistic action of effective anesthetics, indicating that both caine-derivates are effective as single-drug anesthetics for surgical interventions in anamniotes.

  1. Alpha radioactivity monitoring related to Radon-222 in water from wells in metropolitan area of Curitiba (PR), Brazil; Monitoramento da radioatividade alfa relacionada ao radonio-222 em aguas de pocos da regiao metropolitana de Curitiba (PR)

    Energy Technology Data Exchange (ETDEWEB)

    Correa, Janine Nicolosi; Paschuk, Sergei Anatolyevich; Kappke, Jaqueline; Claro, Flavia Del; Perna, Allan Felipe Nunes; Reque, Marilson, E-mail: janine_nicolosi@hotmail.com [Universidade Tecnologica Federal do Parana (UTFPR), Curitiba, PR (Brazil); Denyak, Valeriy; Schelin, Hugo Reuters [Instituto de Pesquisa Pele Pequeno Principe (IPPPP), Curitiba, PR (Brazil); Rocha, Zildete; Santos, Talita Oliveira [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2015-04-15

    This research objective was to assess the level of randon-222 concentration in well water of the metropolitan region of Curitiba, Parana. Current work presents the results of indoor {sup 222}Rn activity ground water samples from artesian wells from aquifers of the region. The studies of radon activity in water were performed using the radon detector AlphaGUARD. The calculations of initial radon activity in water were done considering the {sup 222}Rn decay correction as well as equilibrium level of {sup 222}Rn and {sup 226}Ra observed after 30 days of measurements. Obtained results show that about 70% of measured activity levels of {sup 222}Rn are higher than the recommended value of 11.1 Bq.L{sup -1}, which represent the risk for the human health associated with this radionuclide. The case study showed that previous measurements of radon are recommended for a construction project is implemented. In this case, it is observed that the radon concentrations decrease about 56% in the first water tank and 83% in the second water tank over the well. This fact shows that the actions for mitigation of radon are viable and do not require major modifications to the usual systems of construction. (author)

  2. 用氡-222评价五缘湾的地下水输入%Assessment of submarine groundwater discharge into the Wuyuan bay via continuous Radon-222 measurements

    Institute of Scientific and Technical Information of China (English)

    郭占荣; 李开培; 袁晓婕; 章斌; 马志勇

    2012-01-01

    In recent years, submarine groundwater discharge (SGD) has been recognized as an important process in land-ocean interactions in the coastal zone (LOICZ). The subject has thus become the focus of intensive research. Geochemical tracers can be effective tools for estimating SGD in LOICZ. The objective of this study is to estimate SGD in the Wuyuan Bay using Radon-222 (222Rn) as naturally occurring tracer. The dynamic variation of SGD can thus be subsequently assessed. We continuously measure the seawater 222Rn and 226Ra activities, the near-sea surface air Rn, wind speed, sea water temperature and depth for two consecutive days. We also deploy an incubation device to measure the diffusive flux of 222Rn from sediments and the pore-water 222Rn activities. Based on the mass balance principle for the 222Rn flux, the measured seawater 222Rn are corrected for the decay product of parent 226Ra, the effects of tides, the losses to the atmosphere, the diffusive influxes from the sediments, and the mixing with offshore seawaters. The result shows a conservative estimate of 222Rn flux attributed to SGD is between 0 and 126.7 Bq/(m2 h) , which can account for 54% 222Rn in seawater. Taking a SGD end-member as example, the calculated SGD input rates range from 0 to 29. 3 cm/d with an average value of 9. 3 cm/d. The end-member is made of the weighted average of ground-water and pore-water 222Rn activities. The fluctuation in the SGD input rate has a 12-h period, which matches well with the semi-diurnal tides in this region. The SGD input to the Wuyuan Bay could be as much as 1. 86 X 105 mVd if the estimation were made under the assumption that the average SGD input rate is applicable to the entire bay area. The input of terrestrially derived fresh groundwater in the Wuyuan Bay could be approximately 1. 86 X 104 mVd if the fresh groundwater were 10% of the total SGD input.%海底地下水排泄(SGD)近年来成为陆-海相互作用的研究热点,地球化学示踪方法是其主

  3. Calibration factor determination for solid nuclear track detectors CR-39 type exposed to Rn-222; Determinacao do fator de calibracao para detectores solidos de tracos nucleares tipo CR-39 expostos a Rn-222

    Energy Technology Data Exchange (ETDEWEB)

    Cazula, Camila Dias; Campos, Marcia Pires de; Mazzilli, Barbara Paci, E-mail: cdcazula@ipen.br, E-mail: mpcampos@ipen.br, E-mail: mazzilli@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2014-07-01

    In the detection method with solid nuclear track detector, when a heavy particle rests on the detector surface, causes a breakdown in their molecular structure forming a trace. One of the typical applications of these detectors is the measurement of the concentration of Rn -222 in air, a noble radioactive gas, part of the U-238 series, emitting alpha particles and important in epidemiological studies to protect individuals from natural radiation. To determine the concentration of Rn -222 in the air in a room is necessary to know the density of lines (traces / cm{sup 2}) on the detector surface, the exposure time and the calibration factor. The determination of the calibration factor for CR-39 detectors was taken from the exposure of these to a known concentration of Rn-222. Therefore, the detectors were placed inside a cell of Lucas adapted and subsequently exposed to a concentration of Rn-222 15 kBq / m{sup 3}, by means of the apparatus RN-150 Pylon Electronics Incorporation, which has a source of Ra-226 and releases known concentrations of Rn-222. Six calibration factor determinations were performed, the average value obtained was 0.0534 ±0.0021 (traces / cm{sup 2} per Bq / m{sup 3} day). The results are consistent with literature values for the same type of detector and showed good reproducibility.

  4. Application of {sup 222} Rn as a tracer of groundwater discharge at the coastal zone of Ubatuba, Sao Paulo State, Brazil; Aplicacao de {sup 222} Rn como tracador da descarga de aguas subterraneas na regiao costeira de Ubatuba, Sao Paulo

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Joselene de; Farias, Luciana A.; Mazzilli, Barbara P. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil). Dept. de Radiometria Ambiental]. E-mail: jolivei@net.ipen.br; Burnett, William C. [Florida State Univ., Tallahassee, FL (United States); Saraiva, Elisabete de S.B. e; Furtado, Valdenir V. [Sao Paulo Univ., SP (Brazil). Inst. Oceanografico. Dept. de Oceanografia Quimica e Geologica

    2002-07-01

    Submarine groundwater discharge (SGD) and recycled seawater can provide chemical constituents to coastal zone, representing an important material flux pathway from land to sea in some areas. Geochemical tracers, like {sup 222} Rn and {sup 226} Ra, are advantageous for regional-scale assessment of SGD, because their signals represent values integrated through the water column that removes small-scale variations. These radionuclides are usually enriched in groundwater compared to seawater, can be measured at very low concentrations and are conservative. This work reports preliminary results of a study carried out in a series of small embayements of Ubatuba, Sao Paulo State-Brazil, covering latitudes between 23 deg 26{sup '}S and 23 deg 46{sup '}S and longitudes between 45 deg02{sup '}W and 45 deg 11{sup '}W. The main aims of this research were to set up an analytical method to assess {sup 222} Rn and {sup 226} Ra activities in seawater samples and to apply the excess {sup 222} Rn inventories obtained to estimate the submarine groundwater discharge. Measurements made during 2001/2002 included {sup 222} Rn and {sup 226} Ra in seawater, {sup 222} Rn in sediment, seawater and sediment physical properties. (author)

  5. Determining the 222Rn exhalation rate of building materials using liquid scintillation counting.

    Science.gov (United States)

    van Dijk, W; de Jong, P

    1991-10-01

    A new method for determining the free 222Rn exhalation rate from building materials is described. The sample is enclosed in a container from which the exhaled Rn is continuously purged by nitrogen gas. After 2-3 h, when the Rn level in the container has reached a steady-state concentration, the outflowing Rn is trapped on silica gel at about -190 degrees C. About 16 h after sampling, the silica gel is analyzed by liquid scintillation counting to determine the area exhalation rate. The method described has a good repeatability and reproducibility with coefficients of variation of 7.8% and 8.3%, respectively, at 5 Bq m-2 h-1. The low limit of detection of 11 mBq 222Rn offers the opportunity to quantify the exhalation rate of almost all kinds of building materials. It was found that the air humidity strongly influences the exhalation rates of building material and, therefore, should be controlled. Two typical building materials were investigated. For gypsum, an increase in the exhalation rate with increasing water vapor pressure was found, whereas for concrete, a linear decrease with increasing water vapor pressure was observed. The 222Rn area exhalation rates of 20 Dutch building materials, including some experimental ones, were determined at 50% RH, 20 degrees C, showing a range of less than 0.02-15.8 Bq m-2 h-1. The lowest values were found for natural gypsum board, the highest for phosphogypsum blocks. Building materials containing fly ash gave area exhalation rates comparable to those of similar materials without fly ash.

  6. Exhalation velocity of radon-222 of Dutch building materials and the influence of paint systems

    International Nuclear Information System (INIS)

    In order to achieve a better insight concerning the source terms of radon in the Dutch dwelling in the framework of the RENA-programme an investigation has been performed into the exhalation velocity of radon-222 from building materials. From this investigation it turned out that the ventilation factor does not have any influence upon the exhalation velocity, neither an influence of alteration of air pressure could be demonstrated. The influence of air humidity upon the exhalation velocity showed a twofold picture; for gypsum a linear increase of the exhalation velocity with vapour pressure was found, while for concrete a linear decrease with vapour pressure was observed. Further it has been investigated in how far paint systems diminish the exhalation velocity of the Rn-222 from gypsum and concrete. Acryl paints, mostly used in the Dutch dwelling, did not show a decrease of the exhalation velocity and structure paints did even cause an increase of the exhalation velocity. Other types of paint based on chlorous rubber, epoxy resins and poly-urethane, in contrast, showed a clear reduction. From these those based on poly-urethane showed the largest reduction (60-75%) at a double sided treatment of the wall. With the help of a mathematical modelling of the exhalation estimations have been made of the exhalation velocity of Rn-222 at single sided treatment of a wall and for the exhalation velocity of Rn-220. For the fore mentioned poly-urethane-paints this yelds, at an estimate, a reduction of respectively 90-95% and 100%. (author). 40 refs.; 15 figs.; 8 tabs

  7. Modeling study of gaseous Rn-222, Xe-133, and He-4 for uranium exploration

    Energy Technology Data Exchange (ETDEWEB)

    Jeter, H.W.

    1980-01-01

    This work presents one-dimensional mathematical models to simulate the transport of gaseous radon-222 (Rn-222), xenon-133 (Xe-133), and helium-4 (He-4) away from uranium ore deposits. The resulting concentrations of indicator nuclides in the overburden are used to infer the detectability of ore deposits by emanation methods. In the case of homogeneous, non-radioactive formations, Rn-222 and some of its daughter products are calculated to be detectable at distances of several tens of meters from a planar uranium ore deposit (1 m tickness, 0.6% U/sub 3/O/sub 8/, 20% emanation). Models of He-4 diffuson in rock yield highly uncertain results because measurements of diffusion coefficients in actual rock types are lacking and because the flux of helium from deep within the earth is generally unknown. Comparisons of model results to field data suggest that He-4 diffusion coefficients of 10/sup -4/ to 10/sup -5/ cm/sup 2//sec are appropriate. It is speculated that moisture in the rock column could reduce the coefficient significantly compared to the dry-soil case. Inhomogeneity in rock formations is simulated by a multiple-layer model. A comparison of fluorometric uranium data to gamma spectra measurements suggests the migration and deposition of Ra-226 near the water table. Modeling results are improved when this process is taken into account. A constant soil gas velocity of 1 x 10/sup -4/ cm/sec causes indicator concentrations to change by several orders of magnitude. If steady upward soil gas motion exists in nature, the detectability of uranium ore by emanation methods will be significantly different from that indicated by pure diffusion models. Barometric influences on gas transport are simulated by time-dependent numerical models.

  8. Using {sup 222}Rn as a tracer of geodynamical processes in underground environments

    Energy Technology Data Exchange (ETDEWEB)

    Valladares, D.L. [GEA, Instituto de Matemática Aplicada San Luis (IMASL), Universidad Nacional de San Luis, Consejo Nacional de Investigaciones Científicas y Técnicas, Ej. de los Andes 950, D5700HHW San Luis (Argentina); Silva, A.A.R. da [Instituto de Física, Universidade de São Paulo, P.O.Box 66318, 05314-970, São Paulo, SP (Brazil); Serviço Especializado em Engenharia de Segurança e Medicina do Trabalho, Departamento de Saúde, Universidade de São Paulo, Rua da Reitoria, 109, 05508-900, São Paulo, SP (Brazil); Lacerda, T. [Instituto de Física, Universidade Federal Fluminense, Av. Gal Milton Tavares de Souza, s/n" o, Gragoatá, 24210-340, Niterói, RJ (Brazil); Anjos, R.M., E-mail: meigikos@if.uff.br [Instituto de Física, Universidade Federal Fluminense, Av. Gal Milton Tavares de Souza, s/n" o, Gragoatá, 24210-340, Niterói, RJ (Brazil); Rizzotto, M.; Velasco, H.; Rosas, J.P. de [GEA, Instituto de Matemática Aplicada San Luis (IMASL), Universidad Nacional de San Luis, Consejo Nacional de Investigaciones Científicas y Técnicas, Ej. de los Andes 950, D5700HHW San Luis (Argentina); Tognelli, G. [Departamento de Geología, Universidad Nacional de San Luis, Ej. de los Andes 950, D5700HHW San Luis (Argentina); and others

    2014-01-01

    Radon levels in two old mines in San Luis, Argentina, were measured and analyzed, with the aim to assess the potential use of this radioactive noble gas as a tracer of geological processes in underground environments. La Carolina gold mine and Los Cóndores tungsten mine are today used as tourism mines. CR-39 nuclear track detectors were used for this purpose. Measurements were performed during both winter and summer seasons. The findings show that in these environments, significant radon concentrations are subject to large seasonal fluctuations, due to the strong dependence on natural ventilation with the outside temperature variations. For both mines, higher concentration values of {sup 222}Rn were observed in summer than in winter; with an extreme ratio of 2.5 times between summer and winter seasons for Los Cóndores mine. The pattern of radon transport inside La Carolina mine revealed, contrary to what was believed, that this mine behaves as a system with two entrances located at different levels. However, this feature can only be observed in the winter season, when there is a marked difference between the inside and outside temperatures of the mine. In the case of Los Cóndores mine, the radon concentration pattern distribution is principally established by air current due to chimney-effect in summer and winter seasons. In both cases, the analyses of radon pattern distribution appear as a good method to trace air currents, and then localize unknown ducts, fissures or secondary tunnels in subterranean environments. - Highlights: • {sup 222}Rn levels in two old mines in San Luis, Argentina • CR-39 nuclear track detectors were used for this purpose • higher concentration values of {sup 222}Rn were observed in summer than in winter • radon pattern distribution appear as a good method to trace air currents • it localizes unknown ducts, fissures or secondary tunnels in subterranean environments.

  9. Modeling study of gaseous Rn-222, Xe-133, and He-4 for uranium exploration

    International Nuclear Information System (INIS)

    This work presents one-dimensional mathematical models to simulate the transport of gaseous radon-222 (Rn-222), xenon-133 (Xe-133), and helium-4 (He-4) away from uranium ore deposits. The resulting concentrations of indicator nuclides in the overburden are used to infer the detectability of ore deposits by emanation methods. In the case of homogeneous, non-radioactive formations, Rn-222 and some of its daughter products are calculated to be detectable at distances of several tens of meters from a planar uranium ore deposit (1 m tickness, 0.6% U3O8, 20% emanation). Models of He-4 diffuson in rock yield highly uncertain results because measurements of diffusion coefficients in actual rock types are lacking and because the flux of helium from deep within the earth is generally unknown. Comparisons of model results to field data suggest that He-4 diffusion coefficients of 10-4 to 10-5 cm2/sec are appropriate. It is speculated that moisture in the rock column could reduce the coefficient significantly compared to the dry-soil case. Inhomogeneity in rock formations is simulated by a multiple-layer model. A comparison of fluorometric uranium data to gamma spectra measurements suggests the migration and deposition of Ra-226 near the water table. Modeling results are improved when this process is taken into account. A constant soil gas velocity of 1 x 10-4 cm/sec causes indicator concentrations to change by several orders of magnitude. If steady upward soil gas motion exists in nature, the detectability of uranium ore by emanation methods will be significantly different from that indicated by pure diffusion models. Barometric influences on gas transport are simulated by time-dependent numerical models

  10. Estimation of the global 222Rn flux density from the earth's surface

    International Nuclear Information System (INIS)

    Global 222Rn flux density distributions with a spatial resolution of 1deg in latitude and longitude were estimated for each month in the period of 1979-2007 using an 222Rn exhalation model based on a porous media diffusion theory. This exhalation model calculated the 222Rn flux density as a function of the 226Ra content, soil water saturation, and soil temperature. The influence of the topographical ruggedness of the ground surface on the flux density was also considered in the model. The global average of the flux density during the 29-year period was estimated to be 21.3 mBq m-2 s-1. The annual variation in the globally averaged flux density showed a slight but steady increase since 1999. The seasonal variation in the globally averaged flux density was estimated to range from a minimum of 18.8 mBq m-2 s-1 in March to a maximum of 23.6 mBq m-2 s-1 in September. The regional averages for the annual flux density varied from 8.3 mBq m-2 s-1 for the northern part of North America to 33.5 mBq m-2 s-1 for Australia. The latitudinal distribution of zonally averaged flux density was found to be in good agreement with the latitudinal decline at high latitudes in the Northern Hemisphere. The spatial and temporal variations were caused mainly by variations in the soil water content and soil 226Ra content, but to a lesser extent by the soil temperature. The topographical ruggedness was found to increase the flux density by only 2% globally but by more than 10% in mountainous regions. Atmospheric transport simulation using the estimated flux density as input data showed that the simulated atmospheric 222Rn concentration was substantially lower than that measured at Hachijo Island, implying that the flux density of the present study with topographical ruggedness is still underestimated in the East Asian region. (author)

  11. Analyses of atmospheric radon 222 / canisters exposed by Greenpeace in Niger (Arlit / Akokan sector)

    International Nuclear Information System (INIS)

    The companies SOMAIR and COMINAK, subsidiaries of the AREVA group, are mining uranium deposits in northern Niger. In the course of a field mission carried out in November 2009, a Greenpeace International team deposited detectors (canisters of activated charcoal) to measure radon 222, a radioactive gas formed by the decay of the radium 226 present in the uranium ore. This report includes the results of the analysis of the activated charcoal canisters conducted in CRIIRAD's laboratory, and a brief commentary on the interpretation of the results. (authors)

  12. Tris{N-[bis(dimethylaminophosphinoyl]-2,2,2-trichloroacetamido}(triphenylphosphine oxideholmium(III

    Directory of Open Access Journals (Sweden)

    Oleksiy V. Amirkhanov

    2010-06-01

    Full Text Available In the title compound, [Ho(C6H12Cl3N3O2P3(C18H15OP], the HoIII ion is surrounded by six O atoms from the three bidentate N-[bis(dimethylaminophosphinoyl]-2,2,2-trichloroacetamido ligands (L− and by one O atom from the triphenylphosphine oxide ligand, with the formation of a distorted monocapped octahedron. In one ligand L−, the trichloromethyl group is rotationally disordered between two orientations in a 1:1 ratio, while two dimethylamino groups in another ligand L− are disordered between two conformations, each with the same 1:1 ratio.

  13. 222 Rn determination and physicochemical characteristic and biological in aquifers in the Toluca Valley

    International Nuclear Information System (INIS)

    Concentration levels of 222 Rn and 226 Rn have been analyzed in water samples from boreholes belonging to the drinking water supply system around Toluca, Mexico. The 222 Rn source is the decay of 226 Rn within the solid matrix of the aquifer. The study was performed during the dry and rainy seasons. 222 Rn concentration was determined by the liquid scintillation technique, 226 Rn was determined by gamma spectrometry, the physicochemical parameters and bacteriological analysis were performed by conventional chemical techniques. Solubilized trace elements were determined by Inductively Coupled Plasma - Mass Spectrometry (Icp-Ms). The radon level fluctuations at the boreholes in Toluca city and Almoloya spring indicated differences in the radon content. At borehole Lodos Prietos 2, the temperature and radon level were systematically the highest in comparison with the other boreholes and the spring indicating a contribution of a regional flow to the water of this particular borehole. The result for 226 Rn, the average 222 Rn observed during the sampling period, no correspondence occurs between the radium and the radon content indicating that, radon is not supported by radium, but is incorporated into the water through fissures in the rocks in contact with the water. The radon levels obtained in house faucets which water is supplied by boreholes decrease as a function of the distance from the source borehole to the house. With the chemical composition of each one of the studied boreholes and spring a Piper diagram was draw indicating the kind of water. The boreholes and spring can be classified as bicarbonate calcium/magnesium. Almost no fluctuation on time was observed in the chemical species and trace elements only a slight increase was observed at the end of the rain season. At Almoloya, spring pollution with coliform bacteria and nitrates showed an anthropogenic contribution to the water deterioration probable and fertilizers and detritus. Most of the studied water

  14. Environmental benefits of parking-integrated photovoltaics: A 222kWp experience

    DEFF Research Database (Denmark)

    Serrano-Luján, Lucía; García-Valverde, Rafael; Espinosa, Nieves;

    2015-01-01

    The life cycle assessment of a grid-connected, parking integrated, 222kWp cadmium telluride photovoltaic system has been performed. The system was built at the University of Murcia and has been monitored for 2.5years (sampling data every 5min). The detailed material inventory, the energy embedded...... integration (in this case parking integration) have been quantified using a standard methodology for the calculation of several environmental parameters. Finally, the environmental benefits of renewable energy generation because of the savings of producing the same amount of electricity by the Spanish grid...

  15. Design and construction of a system for determining Radon-222 through Alpha spectroscopy

    International Nuclear Information System (INIS)

    The study of the present work consists on designing a system to measure gas 222 Rn, using a surface barrier detector, in order to obtaining a more accuracy measure of this isotope by means of an alpha particle spectra and thus to try to avoid the influence of the radioactivity of the isotope descendants of short half life, which are also emitting of alpha particles, since by other methods its should make a series of corrections to obtain the real value of the radon activity. (Author)

  16. Uranium, radon-222 and polonium-210 in drinking waters from metropolitan area of Recife, PE, Brazil

    International Nuclear Information System (INIS)

    There is only scarce information on the presence of radionuclides in water for public consumption in Brazil. A recently issued federal regulation requires that waters from public supplies be screened to determine their content of alpha and beta emitters. In order to comply with this requirement the present work was carried out with the purpose of determining the concentration of natural uranium, 222 Rn and 210 Po in water supplies in the metropolitan region of Recife, Brazil. The analyses were performed in 17 points of supply of superficial water and 94 points of groundwater supply. The concentrations of uranium were determined by the fluorimetric method, whereas the liquid scintillation method was used to determine the concentration of 222 Rn. Polonium-210, on the other hand, was determined by alpha spectrometry, following its spontaneous deposition on copper disks. The water analyzer presented uranium concentrations varying from 35.3 to 1146.5 mBq/L for superficial resources and from 20.2 to 919.15 mBq/L for underground sources. The concentration of uranium in superficial water showed significant correlation with some parameters such as conductivity, alkalinity and total hardness, as well as, with the concentrations of Ca, Mg, Cl, K, SO4 and Mn. No correlation, however, was shown with the concentrations of Fe, NO2 and NO3. The concentrations of 222 Rn varied from 5.3 to 83.7 Bq/L in the groundwater analyzer. Radon concentration was not measured in superficial water due to the high emanation rate of radon in open air conditions. As far as 210 Po is concerned, the analyses showed concentrations ranging from 210 Po did not show and correlation with physico-chemical parameters. The average concentrations of uranium and 210 Po in superficial water were of 44.7 mBq/L, respectively. These values correspond to effective doses of 5.8 x 10-4 mSv/yr and 4.5 x 10-2 mSv/yr, for uranium and 210 Po, respectively. The average values for the concentrations of uranium, 222 Rn and

  17. Grignard-mediated reduction of 2,2,2-trichloro-1-arylethanones.

    Science.gov (United States)

    Essa, Ali H; Lerrick, Reinner I; Çiftçi, Eçe; Harrington, Ross W; Waddell, Paul G; Clegg, William; Hall, Michael J

    2015-05-28

    2,2,2-Trichloro-1-aryl-ethanones can be reduced by RMgX to the corresponding 2,2-dichloro-1-arylethen-1-olates and trapped with a range of electrophiles resulting in either reduction, reduction/aldol, reduction/Claisen condensation or reduction/aldol-Tishchenko products. In addition we demonstrate that 2,2-dichloro-1-arylethen-1-olates undergo counter-ion controlled Darzens condensations, which can be followed by a thermal rearrangement as a route to 1,3-diaryl-3-chloropropane-1,2-diones. PMID:25906144

  18. (±)-trans-3-Benzoyl-bicyclo-[2.2.2]octane-2-carboxylic acid.

    Science.gov (United States)

    Lalancette, Roger A; Thompson, Hugh W; Brunskill, Andrew P J

    2008-01-01

    The title keto acid, C(16)H(18)O(3), displays significant twisting of all three ethyl-ene bridges in its bicyclo-[2.2.2]octane structure owing to steric inter-actions; the bridgehead-to-bridgehead torsion angles are 13.14 (12), 13.14 (13) and 9.37 (13)°. The compound crystallizes as centrosymmetric carboxyl dimers [O⋯O = 2.6513 (12) Å and O-H⋯O = 178°], which have two orientations within the cell and contain no significant carboxyl disorder. PMID:21201657

  19. (±-trans-3-Benzoylbicyclo[2.2.2]octane-2-carboxylic acid

    Directory of Open Access Journals (Sweden)

    Andrew P. J. Brunskill

    2008-09-01

    Full Text Available The title keto acid, C16H18O3, displays significant twisting of all three ethylene bridges in its bicyclo[2.2.2]octane structure owing to steric interactions; the bridgehead-to-bridgehead torsion angles are 13.14 (12, 13.14 (13 and 9.37 (13°. The compound crystallizes as centrosymmetric carboxyl dimers [O...O = 2.6513 (12 Å and O—H...O = 178°], which have two orientations within the cell and contain no significant carboxyl disorder.

  20. Detection of Solar Rotational Variability in the Large Yield RAdiometer (LYRA) 190 - 222 nm Spectral Band

    Science.gov (United States)

    Shapiro, A. V.; Shapiro, A. I.; Dominique, M.; Dammasch, I. E.; Wehrli, C.; Rozanov, E.; Schmutz, W.

    2013-08-01

    We analyze the variability of the spectral solar irradiance during the period from 7 January 2010 until 20 January 2010 as measured by the Herzberg channel (190 - 222 nm) of the Large Yield RAdiometer (LYRA) onboard PROBA2. In this period of time, observations by the LYRA nominal unit experienced degradation and the signal produced by the Herzberg channel frequently jumped from one level to another. Both factors significantly complicate the analysis. We present the algorithm that allowed us to extract the solar variability from the LYRA data and compare the results with SORCE/SOLSTICE measurements and with modeling based on the Code for the Solar Irradiance (COSI).

  1. Detection of Solar Rotational Variability in the LYRA 190 - 222 nm Spectral Band

    CERN Document Server

    Shapiro, A V; Dominique, M; Dammasch, I E; Wehrli, C; Rozanov, E; Schmutz, W

    2012-01-01

    We analyze the variability of the spectral solar irradiance during the period from 7 January, 2010 until 20 January, 2010 as measured by the Herzberg channel (190-222 nm) of the Large Yield RAdiometer (LYRA) onboard PROBA2. In this period of time observations by the LYRA nominal unit experienced degradation and the signal produced by the Herzberg channel frequently jumped from one level to another. Both these factors significantly complicates the analysis. We present the algorithm which allowed us to extract the solar variability from the LYRA data and compare the results with SORCE/SOLSTICE measurements and with modeling based on the Code for the Solar Irradiance (COSI).

  2. Radiation Protection. Measurement of radioactivity in the environment - Air- radon 222. A proposed ISO standard.

    Science.gov (United States)

    Gillmore, G.; Woods, M.

    2009-04-01

    Radon isotopes (222, 220, 219) are radioactive gases produced by the disintegration of radium isotopes 226, 224 and 223, which are decay products of uranium238, thorium232 and uranium235 respectively. All are found in the earth's crust. Solid elements, also radioactive, are produced by radon disintegration. Radon is classed as a rare gas in the periodic table of elements, along with helium, argon, neon, krypton and xenon. When disintegrating, radon emits alpha particles and generates solid decay products, which are also radioactive (polonium, bismuth, lead etc.). The potential danger of radon lies in its solid decay products rather than the gas itself. Whether or not they are attached aerosols, radon decay products can be inhaled and deposited in the bronchopulmonary tree to varying depths according to their size. Radon today is considered to be the main source of human exposure to natural radiation. At the international level, radon accounts for 52% of global average exposure to natural radiation. Isotope 222 (48%) is far more significant than isotope 220 (4%), whilst isotope 219 is considered as negligible. Exposure to radon varies considerably from one region to another, depending on factors such as weather conditions, and underlying geology. Activity concentration can therefore vary by a factor of 10 or even a 100 from one period of time to the next and from one area to another. There are many ways of measuring the radon 222 activity concentration and the potential alpha energy concentration of its short-lived decay products. Measuring techniques fall into three categories: - spot measurement methods; continuous measurement; integrated measurement. The proposed ISO (International Organisation for Standardisation) document suggests guidelines for measuring radon222 activity concentration and the potential alpha energy concentration of its short-lived decay products in a free (environment) and confined (buildings) atmosphere. The target date for availability of

  3. Radium-226 and radon-222 in domestic water of Houston-Harris County, Texas

    International Nuclear Information System (INIS)

    This study showed that anomalous concentrations of Ra-226 and Rn-222 exist in parts of the upper Texas Gulf Coast. While all factors influencing the distribution and fate of pollutants in underground porous media might not be easy to measure or even identify, often the very expectation of this great complexity prevents one from observing patterns that otherwise might be quite helpful. The findings summarized in this communication present an encouraging picture for predicting depths and locations in the Gulf Coast where elevated Ra and Rn concentrations may be encountered. Two to four key variables accounted for the statistically significant variation (from 38 to 74 percent) in concentrations observed under field conditions

  4. Investigations on the Formation of 4-Aminobicyclo[2.2.2]-octanones

    Directory of Open Access Journals (Sweden)

    Robert Weis

    2005-05-01

    Full Text Available Benzylidene acetone reacts with thiocyanates derived from secondary amines in a one-pot reaction to give 4-aminobicyclo[2.2.2]octan-2-ones. The reaction mixture was investigated for the presence of possible intermediates using GC-MS. These intermediates – diketones and enamines – were prepared and exposed to the same reaction conditions to examine the reaction mechanism. The reaction of ethyl styryl ketone with thiocyanates of secondary amines yielded cyclohexanone derivatives instead of the expected bicyclo- octanones. Their structures were established by means of a single crystal structure analysis.

  5. Reflection matrices with $U_q[osp^{(2)}(2|2m)]$ symmetry

    CERN Document Server

    Vieira, R S

    2016-01-01

    In this work we report and classify the reflection $K$ matrices with the $U_q[osp^{(2)}(2|2m)]$ symmetry. This correspond to a special case of the multiparametric $U_q[osp^{(2)}(2n+2|2m)]$ vertex model which, for $m=0$, reduces to the multiparametric $U_q[D_{n+1}^{(2)}]$ vertex model. The corresponding reflection $K$ matrices for the multiparametric $U_q[D_{n+1}^{(2)}]$ vertex model were presented by us before.

  6. Vapor-Liquid Equilibrium for Binary Mixtures of 1,4-Diazabicyclo[2.2.2]octane with Ethylenediamine, Ethanolamine, and Ethylene Glycol

    Science.gov (United States)

    Trejbal, Jiří

    2009-04-01

    Vapor-liquid equilibria of mixtures of 1,4-diazabicyclo[2.2.2]octane with ethylenediamine, ethanolamine, and ethylene glycol were studied. Ideal behavior in the ethylenediamine and 1,4-diazabicyclo[2.2.2]octane mixture was observed. Ethanolamine and 1,4-diazabicyclo[2.2.2]octane form an azeotrope with a minimum boiling point whereas ethylene glycol and 1,4-diazabicyclo[2.2.2]octane form an azeotrope with a maximum boiling point. Non-ideal behavior of the mixtures was described by the NRTL equation, and the corresponding constants were calculated.

  7. The "gate keeper" role of Trp222 determines the enantiopreference of diketoreductase toward 2-chloro-1-phenylethanone.

    Directory of Open Access Journals (Sweden)

    Hairong Ma

    Full Text Available Trp222 of diketoreductase (DKR, an enzyme responsible for reducing a variety of ketones to chiral alcohols, is located at the hydrophobic dimeric interface of the C-terminus. Single substitutions at DKR Trp222 with either canonical (Val, Leu, Met, Phe and Tyr or unnatural amino acids (UAAs (4-cyano-L-phenylalanine, 4-methoxy-L-phenylalanine, 4-phenyl-L-phenyalanine, O-tert-butyl-L-tyrosine inverts the enantiotope preference of the enzyme toward 2-chloro-1-phenylethanone with close side chain correlation. Analyses of enzyme activity, substrate affinity and ternary structure of the mutants revealed that substitution at Trp222 causes a notable change in the overall enzyme structure, and specifically in the entrance tunnel to the active center. The size of residue 222 in DKR is vital to its enantiotope preference. Trp222 serves as a "gate keeper" to control the direction of substrate entry into the active center. Consequently, opposite substrate-binding orientations produce respective alcohol enantiomers.

  8. Monte Carlo calculations of LR115 detector response to {sup 222}Rn in the presence of {sup 220}Rn

    Energy Technology Data Exchange (ETDEWEB)

    Nikezic, D.; Yu, K.N.

    2000-04-01

    The sensitivities (in m) of bare LR115 detectors and detectors in diffusion chambers to {sup 222}Rn and {sup 220}Rn chains are calculated by the Monte Carlo method. The partial sensitivities of bare detectors to the {sup 222}Rn chain are larger than those to the {sup 220}Rn chain, which is due to the higher energies of alpha particles in the {sup 220}Rn chain and the upper energy limit for detection for the LR115 detector. However, the total sensitivities are approximately equal because {sup 220}Rn is always in equilibrium with its first progeny, which is not the case for the {sup 222}Rn chain. The total sensitivity of bare LR115 detectors to {sup 222}Rn chain depends linearly on the equilibrium factor. The overestimation in {sup 222}Rn measurements with bare detectors caused by {sup 220}Rn in air can reach 10% in normal environmental conditions. An analytical relationship between the equilibrium factor and the ratio between track densities on the bare detector and the detector enclosed in chamber is given in the last part of the paper. This ratio is also affected by {sup 220}Rn, which can disturb the determination of the equilibrium factor.

  9. Dose by {sup 222} Rn in houses of the Chihuahua city; Dosis por {sup 222} Rn en casas-habitacion de la ciudad de Chihuahua

    Energy Technology Data Exchange (ETDEWEB)

    Colmenero S, L.H.; Talamantes F, C. [ITCH II, Ave. de las Industrias 11101, Chihuahua (Mexico); Villalba, M.L. [UACH, Facultad de Ingenieria, Chihuahua (Mexico); Dobson, P.F. [Laboratorio Nacional Lawrence Berkeley, California (United States); Ortalejo M, B. [UACH, Facultad de Enfermeria y Nutriologia, Chihuahua (Mexico)]. e-mail: luis.colmenero@cimav.edu.mx

    2007-07-01

    Full text: The dose equivalent that the population of the Chihuahua city receives due to the radon in air that joined to values of uranium, thorium and potassium due to the floor and radon in water was determined, they give values very above the international and national norms. The state of Chihuahua contains near 56 locations distributed by the whole state. The city of Chihuahua, capital of the state, is surrounded of rocks with great content of uranium, for what their floor also contains to the {sup 226} Ra that generates to the {sup 222} Rn. The construction of the housings of the city of Chihuahua is mainly of brick, block and adobe; the material to elaborate them is take from the rocks and floor of the surroundings, this makes that the radon is presented in a great quantity of houses of this city. As the floor and water they also contain those natural radionuclides, the total dose equivalent that the inhabitants receive is bigger to other cities of the country. Diverse international organizations dedicated to the radioactivity, indicate that the level of the {sup 222} Rn should not surpass the 148 Bq/m{sup 3}, since this gas produces lung cancer. The state of Chihuahua has an index of deaths on the average by lung cancer of double the national average, the capital of the state also has a high index. The radon concentration in a house depends on the construction material with which was made, as well as of the existent climatic conditions. During the day, this concentration depends mainly on the interior temperature, so during the night and dawn increases the radon concentration. The radon is the biggest source of radioactive dose received by the human being and it can generate a problem of public health if the concentration is high during enough time, for what the city of Chihuahua has the geologic and climatic characteristics to have it. This study was carried out in 50 house-room of the city of Chihuahua. Built houses with brick, block and adobe were

  10. Measurements of {sup 222} Rn in the indoor of dwellings in the Argentinean Republic; Mediciones de {sup 222} Rn en el interior de viviendas de la Republica Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Canoba, A.; Lopez, F. [Autoridad Regulatoria Nuclear, Av. Del Libertador 8250 Ciudad de Buenos Aires (1429) (Argentina)]. e-mail: acanoba@cae.arn.gov.ar

    2006-07-01

    The {sup 222} Rn is responsible for approximately half of the dose in the population resultant of the exposure to natural radiation. Most of this dose comes from the inhalation of the offspring of the {sup 222} Rn, and these doses they are specially important in set closed. The concentration of gas radon has been measured in housings of different cities of the Argentinean Republic. The elected cities are representative of the different geologic areas of our territory. For this its were used as detecting measurement method of nuclear tracks, electret detectors and detectors based on the adsorption in activated coal. Its were analyzed a total of 2689 housings from 1983 to the date. The average value of the radon concentration obtained starting from the 2689 monitored housings was of 41.6 Bq.m{sup -3}. The effective annual dose calculated starting from this radon concentration, using a dosimetric factor of 25 {mu}Sv.a{sup -1} (Bq.m{sup -3}), which assumes an equilibrium factor of 0.4, was of 1.04 mSv. Also, with the objective of determining the dose in form more exact, during the year 2000 it put on to point a passive technique for the simultaneous measurement such the radon concentration like of the equilibrium factor. This technique uses in oneself device two detectors of nuclear traces. The average value obtained starting from 204 monitored housings by this method of simultaneous measurement turns out to be 47.1 Bq.m{sup -3} and 0.36 the equilibrium factor, being obtained a value of effective annual dose of 1.38 mSv. It fits to highlight that are very few the values above 200 Bq.m{sup -3} and in any case the 300 Bq.m{sup -3} is overcome. Analyzing the average equilibrium factor measured of 0.36, it was concluded that having assumed an equilibrium factor of 0.4 was adequate, for what for great measurement campaigns it can continue using the simple method that determines only the radon concentration. Comparing the obtained results by both methods, although the first

  11. Determination of {sup 222}Rn and its physico-chemical and biological characteristics in aquifers of Toluca valley; Determinacion de {sup 222}Rn y caracteristicas fisicoquimicas y biologicas en acuiferos del Valle de Toluca

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez, A.; Aranda, P.; Ceballos, S.; Cruz, D.; Jauregui, B.; Lopez, R.; Pena, P.; Salazar, S.; Segovia, N.; Tamez, E. [Instituto nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    In this work it is realized a geochemical study which includes the evaluation of {sup 222} Rn concentration in drinking water wells at Toluca city and a spring water of Almoloya de Juarez municipality at State of mexico. the same is studied about evolution of {sup 222} Rn concentration in water of the hydrating which supply it to those wells. the geochemical evaluation also covers the determination of major and minor elements or trace and the biological analysis of water. The study includes two seasonal cycles, the low water mark one and other the rainy for being able to evaluate the aquifers reloading effects in the water composition. (Author)

  12. PSA discriminator influence on (222)Rn efficiency detection in waters by liquid scintillation counting.

    Science.gov (United States)

    Stojković, Ivana; Todorović, Nataša; Nikolov, Jovana; Tenjović, Branislava

    2016-06-01

    A procedure for the (222)Rn determination in aqueous samples using liquid scintillation counting (LSC) was evaluated and optimized. Measurements were performed by ultra-low background spectrometer Quantulus 1220™ equipped with PSA (Pulse Shape Analysis) circuit which discriminates alpha/beta spectra. Since calibration procedure is carried out with (226)Ra standard, which has both alpha and beta progenies, it is clear that PSA discriminator has vital importance in order to provide precise spectra separation. Improvement of calibration procedure was done through investigation of PSA discriminator level and, consequentially, the activity of (226)Ra calibration standard influence on (222)Rn efficiency detection. Quench effects on generated spectra i.e. determination of radon efficiency detection were also investigated with quench calibration curve obtained. Radon determination in waters based on modified procedure according to the activity of (226)Ra standard used, dependent on PSA setup, was evaluated with prepared (226)Ra solution samples and drinking water samples with assessment of measurement uncertainty variation included. PMID:27016710

  13. Assessment of radon-222 concentrations and exhalation rates of rocks and building materials

    International Nuclear Information System (INIS)

    One hundred samples were collected from two regions (Bir El-Sid and Wady El-Gemal ) in the Nile Valley. It contain various types of igneous and metamorphic rock samples (acidic dykes, intermediate dykes, basic dykes, serpentinite, metagabbro, menalge). Another set of samples were collected from different regions of Germany. Samples were analyzed and the concentrations in Bq/kg dry weight of radium were determined by gamma-ray spectrometry using hyper-pure germanium (HPGe) detector. A direct method is used to measure 222Rn emanated from the samples, which was analyzed in laboratory using the portable radon monitor Prassi. 222Rn activity concentrations (Bq/m3) were in the range from 36.1± 2 to 96.4 ± 6, 17.8 ± 3 to 73.6 ± 4 and 18.0 ± 2 to 188.1 ± 15 Bq/m3 for samples collected from Bir Elsid, Wadi El-Gemal and samples from Germany respectively. The corresponding values of exhalation rates were from 0.0012 to 0.004, 0.005 to 0.015 and 0.007 to 0.0069 Bq/gs for these areas respectively. (author)

  14. Uncertainty and Sensitivity of Alternative Rn-222 Flux Density Models Used in Performance Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Greg J. Shott, Vefa Yucel, Lloyd Desotell

    2007-06-01

    Performance assessments for the Area 5 Radioactive Waste Management Site on the Nevada Test Site have used three different mathematical models to estimate Rn-222 flux density. This study describes the performance, uncertainty, and sensitivity of the three models which include the U.S. Nuclear Regulatory Commission Regulatory Guide 3.64 analytical method and two numerical methods. The uncertainty of each model was determined by Monte Carlo simulation using Latin hypercube sampling. The global sensitivity was investigated using Morris one-at-time screening method, sample-based correlation and regression methods, the variance-based extended Fourier amplitude sensitivity test, and Sobol's sensitivity indices. The models were found to produce similar estimates of the mean and median flux density, but to have different uncertainties and sensitivities. When the Rn-222 effective diffusion coefficient was estimated using five different published predictive models, the radon flux density models were found to be most sensitive to the effective diffusion coefficient model selected, the emanation coefficient, and the radionuclide inventory. Using a site-specific measured effective diffusion coefficient significantly reduced the output uncertainty. When a site-specific effective-diffusion coefficient was used, the models were most sensitive to the emanation coefficient and the radionuclide inventory.

  15. Measurement of 222Rn dissolved in water at the Sudbury Neutrino Observatory

    CERN Document Server

    Blevis, I

    2004-01-01

    The technique used at the Sudbury Neutrino Observatory (SNO) to measure the concentration of 222Rn in water is described. Water from the SNO detector is passed through a vacuum degasser (in the light water system) or a membrane contact degasser (in the heavy water system) where dissolved gases, including radon, are liberated. The degasser is connected to a vacuum system which collects the radon on a cold trap and removes most other gases, such as water vapor and nitrogen. After roughly 0.5 tons of H2O or 6 tons of D2O have been sampled, the accumulated radon is transferred to a Lucas cell. The cell is mounted on a photomultiplier tube which detects the alpha particles from the decay of 222Rn and its daughters. The overall degassing and concentration efficiency is about 38% and the single-alpha counting efficiency is approximately 75%. The sensitivity of the radon assay system for D2O is equivalent to ~3 E(-15) g U/g water. The radon concentration in both the H2O and D2O is sufficiently low that the rate of ba...

  16. VdBH 222: a starburst cluster in the inner Milky Way

    CERN Document Server

    Marco, A; González-Fernández, C; Apellániz, J Maíz; Dorda, R; Clark, J S

    2014-01-01

    It has been suggested that the compact open cluster VdBH 222 is a young massive distant object. We set out to characterise VdBH 222 using a comprehensive set of multi-wavelength observations. We obtained multi-band optical (UBVR) and near-infrared (JHK) photometry of the cluster field, as well as multi-object and long-slit optical spectroscopy for a large sample of stars in the field. We applied classical photometric analysis, as well as more sophisticated methods using the CHORIZOS code, to determine the reddening to the cluster. We then plotted dereddened HR diagrams and determined cluster parameters via isochrone fitting. We have identified a large population of luminous supergiants confirmed as cluster members via radial velocity measurements. We find nine red supergiants (plus one other candidate) and two yellow supergiants. We also identify a large population of OB stars. Ten of them are bright enough to be blue supergiants. The cluster lies behind 7.5 mag of extinction for the preferred value of Rv of ...

  17. Tracing and quantifying groundwater inflow into lakes using a simple method for radon-222 analysis

    Directory of Open Access Journals (Sweden)

    T. Kluge

    2007-09-01

    Full Text Available Due to its high activities in groundwater, the radionuclide 222Rn is a sensitive natural tracer to detect and quantify groundwater inflow into lakes, provided the comparatively low activities in the lakes can be measured accurately. Here we present a simple method for radon measurements in the low-level range down to 3 Bq m−3, appropriate for groundwater-influenced lakes, together with a concept to derive inflow rates from the radon budget in lakes. The analytical method is based on a commercially available radon detector and combines the advantages of established procedures with regard to efficient sampling and sensitive analysis. Large volume (12 l water samples are taken in the field and analyzed in the laboratory by equilibration with a closed air loop and alpha spectrometry of radon in the gas phase. After successful laboratory tests, the method has been applied to a small dredging lake without surface in- or outflow in order to estimate the groundwater contribution to the hydrological budget. The inflow rate calculated from a 222Rn balance for the lake is around 530 m³ per day, which is comparable to the results of previous studies. In addition to the inflow rate, the vertical and horizontal radon distribution in the lake provides information on the spatial distribution of groundwater inflow to the lake. The simple measurement and sampling technique encourages further use of radon to examine groundwater-lake water interaction.

  18. Modeling and experimental validation of the dispersion of 222Rn released from a uranium mine ventilation shaft

    Science.gov (United States)

    Xie, Dong; Wang, Hanqing; Kearfott, Kimberlee J.

    2012-12-01

    Radon (222Rn) found in uranium mine shaft ventilation exhaust gases could pose hazards to the surrounding environment and the public by virtue of its progeny. Radon migration under complex terrain is complicated by pollution source characteristics, geographical features of the dispersion region, meteorological conditions and precipitation. Fluid dynamics computations of 222Rn dispersion are performed for uranium mine shaft exhausts for complex models of the actual physical terrain corresponding to a mine in the Jiangxi Province of China. The eight cases studied included a ventilation shaft source, four downwind velocities (0.5, 1.0, 2.0, 4.0 m s-1) and two underlying surface roughness characteristics (0.1 m, 1.0 m). 222Rn distributions in the vicinity of uranium mine ventilation shaft are computed and compared with field measurements.

  19. Examining Submarine Ground-Water Discharge into Florida Bay by using 222Rn and Continuous Resistivity Profiling

    Science.gov (United States)

    Swarzenski, Peter; Reich, Chris; Rudnick, David

    2009-01-01

    Estimates of submarine ground-water discharge (SGD) into Florida Bay remain one of the least understood components of a regional water balance. To quantify the magnitude and seasonality of SGD into upper Florida Bay, research activities included the use of the natural geochemical tracer, 222Rn, to examine potential SGD hotspots (222Rn surveys) and to quantify the total (saline + fresh water component) SGD rates at select sites (222Rn time-series). To obtain a synoptic map of the 222Rn distribution within our study site in Florida Bay, we set up a flow-through system on a small boat that consisted of a Differential Global Positioning System, a calibrated YSI, Inc CTD sensor with a sampling rate of 0.5 min, and a submersible pump (z = 0.5 m) that continuously fed water into an air/water exchanger that was plumbed simultaneously into four RAD7 222Rn air monitors. To obtain local advective ground-water flux estimates, 222Rn time-series experiments were deployed at strategic positions across hydrologic and geologic gradients within our study site. These time-series stations consisted of a submersible pump, a Solinist DIVER (to record continuous CTD parameters) and two RAD7 222Rn air monitors plumbed into an air/water exchanger. Repeat time-series 222Rn measurements were conducted for 3-4 days across several tidal excursions. Radon was also measured in the air during each sampling campaign by a dedicated RAD7. We obtained ground-water discharge information by calculating a 222Rn mass balance that accounted for lateral and horizontal exchange, as well as an appropriate ground-water 222Rn end member activity. Another research component utilized marine continuous resistivity profiling (CRP) surveys to examine the subsurface salinity structure within Florida Bay sediments. This system consisted of an AGI SuperSting 8 channel receiver attached to a streamer cable that had two current (A,B) electrodes and nine potential electrodes that were spaced 10 m apart. A separate DGPS

  20. Dose ratio of 222Rn to 220Rn progeny in a pit using in-suit HPGe γ spectrometry

    International Nuclear Information System (INIS)

    To probe potential α energy concentration (PAEC) ratio and dose ratio of 222Rn to 220Rn progeny in a pit, in-situ HPGe γ spectrometry was used under atmospheric ventilation and without atmospheric ventilation conditions. The measurement data was analysed using relative efficiency method and PAEC method. The measurement results show that the average PAEC ratio and dose ratio of 222Rn to 220Rn progeny under without atmospheric ventilation is 3.6 and 10.8, respectively, which is 1.2 and 3.6 in first 8 hours under atmospheric ventilation. After 14 hours atmospheric ventilation, PAEC ratio and dose ratio are 0.2 and 0.6 stably. In-situ HPGe γ spectrometry has a great space in 222Rn and 220Rn dose research in the future. (authors)

  1. The Study of Equilibrium factor between Radon-222 and its Daughters in Bangkok Atmosphere by Gamma-ray Spectrometry

    Science.gov (United States)

    Rujiwarodom, Rachanee

    2010-05-01

    To study the Equilibrium between radon-222 and its daughters in Bangkok atmosphere by Gamma-ray spectrometry, air sample were collected on 48 activated charcoal canister and 360 glass fiber filters by using a high volume jet-air sampler during December 2007 to November 2008.The Spectra of gamma-ray were measured by using a HPGe (Hyper Pure Germanium Detector). In the condition of secular equilibrium obtaining between Radon-222 and its decay products, radon-222 on activated charcoal canister and its daughters on glass fiber filters collected in the same time interval were calculated. The equilibrium factor (F) in the open air had a value of 0.38 at the minimum ,and 0.75 at the maximum. The average value of equilibrium factor (F) was 0.56±0.12. Based on the results, F had variations with a maximum value in the night to the early morning and decreased in the afternoon. In addition, F was higher in the winter than in the summer. This finding corresponds with the properties of the Earth atmosphere. The equilibrium factor (F) also depended on the concentration of dust in the atmosphere. People living in Bangkok were exposed to average value of 30 Bq/m3 of Radon-222 in the atmosphere. The equilibrium factor (0.56±0.12) and the average value of Radon-222 showed that people were exposed to alpha energy from radon-222 and its daughters decay at 0.005 WL(Working Level) which is lower than the safety standard at 0.02 WL. Keywords: Radon, Radon daughters , equilibrium factor, Gamma -ray spectrum analysis ,Bangkok ,Thailand

  2. Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells.

    Science.gov (United States)

    Wei, Yifang; Lai, Xiaofeng; Yu, Shentong; Chen, Suning; Ma, Yongzheng; Zhang, Yuan; Li, Huichen; Zhu, Xingmei; Yao, Libo; Zhang, Jian

    2014-09-01

    Recent studies have demonstrated that specific miRNAs, such as miR-221/222, may be responsible for tamoxifen resistance in breast cancer. Secreted miRNAs enclosed in exosomes can act as intercellular bio-messengers. Our objective is to investigate the role of secreted miR-221/222 in tamoxifen resistance of ER-positive breast cancer cells. Transmission electron microscopy analysis and nanoparticle tracking analysis were performed to determine the exosomes difference between MCF-7(TamR) (tamoxifen resistant) and MCF-7(wt) (tamoxifen sensitive) cells. PKH67 fluorescent labeling assay was used to detect exosomes derived from MCF-7(TamR) cells entering into MCF-7(wt) cells. The potential function of exosomes on tamoxifen resistance transmission was analyzed with cell viability, apoptosis ,and colony formation. MiRNA microarrays and qPCR were used to detect and compare the miRNAs expression levels in the two cells and exosomes. As the targets of miR-221/222, p27 and ERα were analyzed with western blot and qPCR. Compared with the MCF-7(wt) exosomes, there were significant differences in the concentration and size distribution of MCF-7(TamR) exosomes. MCF-7(wt) cells had an increased amount of exosomal RNA and proteins compared with MCF-7(TamR) cells. MCF-7(TamR) exosomes could enter into MCF-7(wt) cells, and then released miR-221/222. And the elevated miR-221/222 effectively reduced the target genes expression of P27 and ERα, which enhanced tamoxifen resistance in recipient cells. Our results are the first to show that secreted miR-221/222 serves as signaling molecules to mediate communication of tamoxifen resistance. PMID:25007959

  3. 222-S radioactive liquid waste line replacement and 219-S secondary containment upgrade, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    The U.S. Department of Energy (DOE) is proposing to: (1) replace the 222-S Laboratory (222-S) radioactive liquid waste drain lines to the 219-S Waste Handling Facility (219-S); (2) upgrade 219-S by replacing or upgrading the waste storage tanks and providing secondary containment and seismic restraints to the concrete cells which house the tanks; and (3) replace the transfer lines from 219-S to the 241-SY Tank Farm. This environmental assessment (EA) has been prepared in compliance with the National Environmental Policy Act (NEPA) of 1969, as amended, the Council on Environmental Quality Regulations for Implementing the Procedural Provisions of NEPA (40 Code of Federal Regulations [CFR] 1500-1508), and the DOE Implementing Procedures for NEPA (10 CFR 1021). 222-S is used to perform analytical services on radioactive samples in support of the Tank Waste Remediation System and Hanford Site environmental restoration programs. Activities conducted at 222-S include decontamination of analytical processing and support equipment and disposal of nonarchived radioactive samples. These activities generate low-level liquid mixed waste. The liquid mixed waste is drained through pipelines in the 222-S service tunnels and underground concrete encasements, to two of three tanks in 219-S, where it is accumulated. 219-S is a treatment, storage, and/or disposal (TSD) unit, and is therefore required to meet Washington Administrative Code (WAC) 173-303, Dangerous Waste Regulations, and the associated requirements for secondary containment and leak detection. The service tunnels are periodically inspected by workers and decontaminated as necessary to maintain as low as reasonably achievable (ALARA) radiation levels. Although no contamination is reaching the environment from the service tunnels, the risk of worker exposure is present and could increase. 222-S is expected to remain in use for at least the next 30 years to serve the Hanford Site environmental cleanup mission

  4. The Inhibition of the Highly Expressed Mir-221 and Mir-222 Impairs the Growth of Prostate Carcinoma Xenografts in Mice

    OpenAIRE

    Neri Mercatelli; Valeria Coppola; Desirée Bonci; Francesca Miele; Arianna Costantini; Marco Guadagnoli; Elena Bonanno; Giovanni Muto; Giovanni Vanni Frajese; Ruggero De Maria; Luigi Giusto Spagnoli; Maria Giulia Farace; Silvia Anna Ciafrè

    2008-01-01

    BACKGROUND: MiR-221 and miR-222 are two highly homologous microRNAs whose upregulation has been recently described in several types of human tumors, for some of which their oncogenic role was explained by the discovery of their target p27, a key cell cycle regulator. We previously showed this regulatory relationship in prostate carcinoma cell lines in vitro, underlying the role of miR-221/222 as inducers of proliferation and tumorigenicity. METHODOLOGY/PRINCIPAL FINDINGS: Here we describe a n...

  5. Genetic effects of radon 222 in a population of Drosophila melanogaster chronically exposed; Efectos geneticos del radon 222 en una poblacion de Drosophila melanogaster cronicamente expuesta

    Energy Technology Data Exchange (ETDEWEB)

    Salceda, V.M. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico). Dept. de Biologia

    1997-07-01

    It was investigated the mutagenic effect of Radon 222 during a experimental period of 11 generations. In this lapse Drosophila melanogaster larvae line Canton-S were maintained in a radon atmosphere. In each test generation had been extracted males, consequently exposed to radiation which were subjected to a crossing series with a bearer marker genes of according to the Wallace experimental design (1956). Due to the experimental conditions it only was determined the recessive lethal mutations frequency for the second chromosome in the 1,4,7 and 11 generations. Of all study it was conduced in parallel way a non-treated witness population. The concentrations at which was subjected the experimental population varied of generation to generation from 12 {+-} 2 to 43 {+-} 5 kBq/m{sup 3}. Our analysis correspond to lethality determination in 1182 second chromosomes distributed between two populations and the different exposition generations. The study allow to determine the respective frequencies of recessive lethal genes varying according to the population and/or generation between 10.53 and 22.02%. The statistical analysis of data did not show significant differences among the different populations. (Author)

  6. Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

    DEFF Research Database (Denmark)

    Vigorito, Elena; Kuchenbaecker, Karoline B; Beesley, Jonathan;

    2016-01-01

    Population-based genome wide association studies have identified a locus at 9p22.2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22.2 to identify potential causal variants in BRCA1 and BRCA2 ...

  7. 36 CFR 222.25 - Protection of wild free-roaming horses and burros when they are upon other than the National...

    Science.gov (United States)

    2010-07-01

    ...-roaming horses and burros when they are upon other than the National Forest System or public lands. 222.25... MANAGEMENT Management of Wild Free-Roaming Horses and Burros § 222.25 Protection of wild free-roaming horses... animals and herds of wild free-roaming horses and burros will be under the protection of the Chief,...

  8. Draft Genome Sequence of the Obligate Halophilic Bacillus sp. Strain NSP22.2, Isolated from a Seasonal Salt Marsh of the Great Rann of Kutch, India

    Science.gov (United States)

    Pal, Kamal Krishna; Sherathia, Dharmesh; Vanpariya, Sejal; Patel, Ilaxi; Dalsania, Trupti; Savsani, Kinjal; Sukhadiya, Bhoomika; Mandaliya, Mona; Thomas, Manesh; Ghorai, Sucheta; Rupapara, Rupal; Rawal, Priya

    2013-01-01

    Here, we report the 4.0-Mbp draft genome of an obligate halophile, Bacillus sp. strain NSP22.2, isolated from a seasonal salt marsh of the Great Rann of Kutch, India. To understand the mechanism(s) of obligate halophilism and to isolate the relevant gene(s), the genome of Bacillus sp. NSP22.2 was sequenced. PMID:24356848

  9. The role of mesoscale meteorology in modulating the 222Rn concentrations in Huelva (Spain) – impact of phosphogypsum piles

    International Nuclear Information System (INIS)

    The combined analysis of 222Rn activity concentrations and mesoscale meteorological conditions at Huelva city (Spain) was addressed in this study to understand the potential impact of phosphogypsum piles on the 222Rn activity concentrations registered at this area. Hourly mean data from April 2012 to February 2013 registered at two sampling sites (Huelva city and in the background station of El Arenosillo, located 27 km to the south-east) have been used in the study. The results of the present study showed a large difference in mean radon concentrations between the two stations during the sampling period, 6.3 ± 0.4 Bq m−3 at Huelva and 3.0 ± 0.2 Bq m−3 at El Arenosillo. The analysis has demonstrated that hourly 222Rn concentrations at Huelva city above 22 Bq m−3, with nocturnal peaks up to 50 Bq/m3, mainly coincided with the occurrence of a pure sea-land breeze cycle. Mesoscale circulations in this region are mainly characterized by two patterns of sea-land breeze, pure and non-pure, with the phosphosypsum piles directly upstream (south) of the city during the afternoon on pure sea-breeze days. The difference between mean 222Rn activity concentrations at Huelva city were 9.9 ± 1.5 Bq m−3 for the pure pattern and 3.3 ± 0.5 Bq m−3 for the non-pure pattern, while in the background station concentrations were 3.9 ± 0.4 Bq m−3 and 2.8 ± 0.4 Bq m−3 respectively. Considering these large differences, a detailed analysis of composites and case studies of representative sea-land breeze cycles of both types and their impact on 222Rn activity concentration was performed. The results suggested that the presence of the phosphogypsum piles was necessary in order to justify the high 222Rn activity concentrations observed at Huelva compared with the background station in the afternoons on pure sea breeze days (1.5–2.0 Bq m−3). On the other hand, large night time differences between the two sites on these days were likely to be

  10. Studying {sup 222}Rn exhalation rate from soil and sand samples using CR-39 detector

    Energy Technology Data Exchange (ETDEWEB)

    Shafi-ur-Rehman [Pakistan Institute of Engineering and Applied Sciences (PIEAS), P.O. Nilore, Islamabad (Pakistan); Matiullah [Pakistan Institute of Engineering and Applied Sciences (PIEAS), P.O. Nilore, Islamabad (Pakistan)]. E-mail: matiullah@pieas.edu.pk; Shakeel-ur-Rehman [Pakistan Institute of Engineering and Applied Sciences (PIEAS), P.O. Nilore, Islamabad (Pakistan); Rahman, Said [Pakistan Institute of Engineering and Applied Sciences (PIEAS), P.O. Nilore, Islamabad (Pakistan)

    2006-07-15

    Accurate knowledge of exhalation rate plays an important role in characterization of the radon source strength in building materials and soil. It is a useful quantity to compare the relative importance of different materials and soil types. Majority of houses in Pakistan are mainly constructed from soil and sand. Therefore, studies concerning the determination of radon exhalation rate from these materials were carried out using CR-39 based NRPB radon dosimeters. In this context, samples were collected from different towns of the Bahawalpur Division, Punjab and major cities of NWFP. After treatment, samples were placed in plastic containers and dosimeters were installed in it at heights of 25cm above the surface of the samples. These containers were hermetically sealed and stored for three weeks to attain equilibrium between {sup 222}Rn and {sup 226}Ra. After exposure to radon, CR-39 detectors were etched in 25% NaOH at 80 deg. C for 16h. From the measured radon concentration values, {sup 222}Rn exhalation rates were determined. It ranged from 1.56 to 3.33Bqm{sup -2}h{sup -1} for the soil collected from the Bahawalpur Division and 2.49-4.66Bqm{sup -2}h{sup -1} for NWFP. The {sup 222}Rn exhalation rates from the sand samples were found to range from 2.78 to 20.8Bqm{sup -2}h{sup -1} for the Bahawalpur Division and from 0.99 to 4.2Bqm{sup -2}h{sup -1} for NWFP. {sup 226}Ra contents were also determined in the above samples which ranged from 28 to 36.5Bqkg{sup -1} in the soil samples collected from the Bahawalpur Division and from 40.9 to 51.9Bqkg{sup -1} in the samples collected from NWFP. In sand samples, {sup 226}Ra contents ranged from 49.2 to 215Bqkg{sup -1} and 22.6-27Bqkg{sup -1} in the samples collected from the Bahawalpur Division and NWFP, respectively. {sup 226}Ra contents in these samples were also determined using HPGe detector. The results of both the techniques are in good agreement within experimental errors.

  11. A preliminary Investigation of 222Rn and 220Rn levels in non-uranium mines in China%我国非铀矿山222Rn和220Rn水平初步调查研究

    Institute of Scientific and Technical Information of China (English)

    尚兵; 崔宏星; 武云云; 张庆召; 苏旭

    2008-01-01

    Objective To measure levels of 222Rn and 220Rn in typical non-uranium mines, China, and to estimate dose from the occupational radon exposure in the miners. Methods Using typical sampling scheme,44 mines were selectcd in 12 provinces, which can be classified into 4 categories and 17 types of mines. The radon-thoron discriminative detectors were used to measure 222Rn and 220Rn concentrations in mines. Result The concentration of 222Rn or 220Rn was log-normally distributed. The arithmetic mean (AM) concentration and geometric mean (GM) concentration of 222Rn and 220Rn in 25 metal mines (n=147) were estimated to be (1211±2359) Bq/m3(AM) and (311±5.5) Bq/m3(GM), and (269±700) Bq/m3(AM) and (71±4.4)Bq/m3(GM), respectively. The mean concentrations of 222Rn and 220Rn in 18 non-metal mines (n=118) were (98±207) Bq/m3(AM) and(55±2.5) Bq/m3(GM), and (60±76) Bq/m3(AM) and (38±2.4)Bq/m3(GM),respectively. In total, we measured 222 Rn concentration in 44 underground mines, 6 of them, accounted for 15%, with the mean radon concentration exceeding 1000 Bqm-3 (limit of workplace in China). Approximately 7% of radon concentration in mines measured were higher than 3700 Bq/m3(current limit in uranium mine in China), some points even exceeded 10 000 Bq/m3. Based on this typical measurements, the equilibrium factor for 222Rn was estimated to be 0.33±0.15 in underground mines and 0.47±0.18 in nearby houses. Equilibrium factor for 222Rn ranged from 0.001 to 0.032. Using the data obtained in this typical survey, the average annual effective dose of underground miners exposed to radon and thoron was estimated to be 8.15 mSv/a. Conclusions High levels of 222Rn exists in metal mines, such as copper, tin, lead and zinc, gold, and aluminum mines among others. More study and administrative measures are needed to address the radiation protection of workers occupationally exposed to high radon in mines.%目的 测量非铀矿山222Rn、220Rn水平,了解我国矿山氡超标比

  12. The Rn-222 with natural tracer in the study of natural gas transport within sterile cells of mining; O Rn-222 como tracador natural no estudo de transporte de gases no interior de pilhas de estereis de mineracao

    Energy Technology Data Exchange (ETDEWEB)

    Chagas, Eduardo G.L. das; Dias, Danila C.S.; Guerrero, Eder T. Z.; Alberti, Heber L.C.; Couto, Jeferson A.; Silva, Nivaldo C., E-mail: duglchagas@hotmail.com, E-mail: ncsilva@cnen.gov.br [Comissao Nacional de Energia Nuclear (LAPOC/CNEN-MG), Pocos de Caldas, MG (Brazil). Laboratorio de Pocos de Caldas; Braz, Marcelo L. [Universidade Federal de Alfenas (UNIFAL), Pocos de Caldas, MG (Brazil); Abreu, Carolina B. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil); Lopez, Dina [Universidade de Ohio (United States); Branco, Otavio [Universidade Federal de Juiz de Fora (UFJF), MG (Brazil); Fleming, Peter M. [Centro de Desenvolvimento de Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2013-07-01

    The objectives of this work are mapping of Rn-222 concentration in the interstitial air of the cell 4 (BF-4) barren of uranium mining in the Industrias Nucleares do Brasil (INB), Pocos de Caldas, MG - Brazil, as well as build an automatic system for collection of interstitial gases.

  13. Progress of miR-221/222 in tumor diagnosis and treatment%miR-221/222在肿瘤诊治中的研究进展

    Institute of Scientific and Technical Information of China (English)

    龙斌; 李林法; 易贺庆

    2016-01-01

    MicroRNAs(miRNA)are a kind of small non -conding RNA,which negative regulate target genes expression at post -transcription level by binding 3'-untraslation region(3'UTR).Dysregulation of miRNA pro-files relate to cancer,immune disorders,cardiovascular disease,neurodegenerative diseases and metabolic diseases. miR -221 /222 are two similary miRNAs,which share the same promoter and have the same seed sequence.miR -221 /222 usually target to same target genes and co -regulate same processes and act as onco -miRNA roles.Howev-er,miR -221 /222 maybe act as suppressor in cancer which maybe dependent particular context.The roles of miR -221 /222 are reviewed in this article,will provide a comprehensive vision for comprehending the biological process of miR -221 /222 in carcinoma.%微小 RNA(microRNAs,miRNAs)是一类短链非编码 RNA,通过与编码基因的3′非翻译区(3′Un-traslation region,3′UTR)结合,发挥转录后负向调控靶基因表达的作用,进而调控相应的生物学功能。其异常表达与肿瘤、免疫失调、心血管疾病、神经退行性疾病和代谢疾病等多种疾病的发生、发展密切相关,并在疾病的治疗、药物代谢等过程发挥重要的作用。miR-221/222是两个序列和结构类似的 miRNA,且具有类似的生物学功能。miR-221/222在多种肿瘤和疾病中差异表达,主要发挥致癌 miRNA(Onco-miRNA)作用。但新近研究表明,在一定背景下 miR-221/222也发挥抑癌基因的作用。本研究对 miR-221/222在疾病中的角色进行综述,展现当前研究的 miR-221/222在肿瘤中的重要生物学功能和机制,为以 miRNA 为靶点的治疗研究提供相关信息。

  14. Radon-222 as an indicator of continental air masses and air mass boundaries over ocean areas

    International Nuclear Information System (INIS)

    Radon (222Rn) has proven to be an excellent indicator of the continental nature of over-ocean air and air mass boundaries. Radon is almost exclusively of continental origin, and low-level real-time monitoring is possible with our improved radon measurement techniques. The transition from continental to maritime air in offshore and onshore winds is rather obvious and can easily be established near large islands or continents as an order-of-magnitude change in radon concentration from a few tens of picocuries per cubic meter or more to a few picocuries per cubic meter or less. Sharply changing radon concentrations are usually associated with frontal areas. Our data have offered insights into air movements, and hence transport of continental materials and pollutants over oceanic areas

  15. Development of Radon-222 as Natural Tracer for Monitoring the Remediation of NAPL in the Subsurface

    Energy Technology Data Exchange (ETDEWEB)

    Brian M. Davis; Lewis Semprini; Jonathan Istok

    2003-02-27

    Naturally occurring 222-radon in ground water can potentially be used as an in situ partitioning tracer to characterize dense nonaqueous phase liquid (DNAPL) saturations. The static method involves comparing radon concentrations in water samples from DNAPL-contaminated and non-contaminated portions of an aquifer. During a push-pull test, a known volume of test solution (radon-free water containing a conservation tracer) is first injected (''pushed'') into a well; flow is then reversed and the test solution/groundwater mixture is extracted (''pulled'') from the same well. In the presence of NAPL radon transport is retarded relative to the conservative tracer. Assuming linear equilibrium partitioning, retardation factors for radon can be used to estimate NAPL saturations.The utility of this methodology was evaluated in laboratory and field settings.

  16. Sampling and analysis for radon-222 dissolved in ground water and surface water

    Science.gov (United States)

    DeWayne, Cecil L.; Gesell, T.F.

    1992-01-01

    Radon-222 is a naturally occurring radioactive gas in the uranium-238 decay series that has traditionally been called, simply, radon. The lung cancer risks associated with the inhalation of radon decay products have been well documented by epidemiological studies on populations of uranium miners. The realization that radon is a public health hazard has raised the need for sampling and analytical guidelines for field personnel. Several sampling and analytical methods are being used to document radon concentrations in ground water and surface water worldwide but no convenient, single set of guidelines is available. Three different sampling and analytical methods - bubbler, liquid scintillation, and field screening - are discussed in this paper. The bubbler and liquid scintillation methods have high accuracy and precision, and small analytical method detection limits of 0.2 and 10 pCi/l (picocuries per liter), respectively. The field screening method generally is used as a qualitative reconnaissance tool.

  17. Effect of shell structure on neutron multiplicity of fissioning systems 220,222,224Th nuclei

    Directory of Open Access Journals (Sweden)

    Goyal Savi

    2015-01-01

    Full Text Available The pre- and post-scission neutron multiplicities have been extracted for the 220,222,224Th nuclei for the excitation energy range of 40 MeV to 64 MeV using the National Array of Neutron Detectors (NAND. The Th isotopes are populated from the fusion reaction of 16O+204,206,208Pb systems in order to investigate the dynamics of fusion-fission reactions using the neutron multiplicity as a probe. The theoretical calculations were performed using the Bohr-Wheeler fission width as well as the dissipative dynamical fission width from Kramers prescription. It is observed that the Bohr-Wheeler fission width underestimates the pre-scission yields to a large extent. A large amount of dissipation is required in the Kramers width to fit the observed pre-scission neutron multiplicities.

  18. Roles of Radon-222 and other natural radionuclides in earthquake prediction

    International Nuclear Information System (INIS)

    The concentration of 222Rn in subsurface waters is one of the natural parameters being investigated to help develop the capability to predict destructive earthquakes. Since 1966, scientists in several nations have sought to link radon variations with ongoing seismic activity, primarily through the dilatancy model for earthquake occurrences. Within the range of these studies, alpha-, beta-, and gamma-radiation detection techniques have been used in both discrete-sampling and continiuous-monitoring programs. These measured techniques are reviewed in terms of instrumentation adapted to seismic-monitoring purposes. A recent Lawrence Berkeley Laboratory study conducted in central California incorporated discrete sampling of wells in the aftershock area of the 1975 Oroville earthquake and continuous monitoring of water radon in a well on the San Andreas Fault. The results presented show short-term radon variations that may be associated with aftershocks and diurnal changes that may reflect earth tidal forces

  19. High-resolution ion pulse ionization chamber with air filling for the 222Rn decays detection

    Science.gov (United States)

    Gavrilyuk, Yu. M.; Gangapshev, A. M.; Gezhaev, A. M.; Etezov, R. A.; Kazalov, V. V.; Kuzminov, V. V.; Panasenko, S. I.; Ratkevich, S. S.; Tekueva, D. A.; Yakimenko, S. P.

    2015-11-01

    The construction and characteristics of the cylindrical ion pulse ionization chamber (CIPIC) with a working volume of 3.2 L are described. The chamber is intended to register α-particles from the 222Rn and its daughter's decays in the filled air sample. The detector is less sensitive to electromagnetic pick-ups and mechanical noises. The digital pulse processing method is proposed to improve the energy resolution of the ion pulse ionization chamber. An energy resolution of 1.6% has been achieved for the 5.49 MeV α-line. The dependence of the energy resolution on high voltage and working media pressure has been investigated and the results are presented.

  20. Removal of the long-lived {sup 222}Rn daughters from copper and stainless steel surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Zuzel, G., E-mail: grzegorz.zuzel@uj.edu.pl [Max Planck Institute for Nuclear Physics, P.O. Box 103 980, D-69029 Heidelberg (Germany); Wojcik, M. [M. Smoluchowski Institute of Physics, Jagiellonian University, Reymonta 4, PL-30-059 Krakow (Poland)

    2012-06-01

    Removal of the long-lived {sup 222}Rn daughters from copper and stainless steel surfaces was investigated. Etching and electropolishing were applied to discs exposed earlier to a strong radon source for {sup 210}Pb, {sup 210}Bi and {sup 210}Po deposition. Cleaning efficiency for {sup 210}Pb was tested with a n-type high purity germanium spectrometer, for {sup 210}Bi a beta spectrometer and for {sup 210}Po an alpha spectrometer was used. According to the performed measurements electropolishing removes very effectively all the isotopes from copper and stainless steel. Copper etching reduces efficiently lead and bismuth however for polonium the effect is negligible because of its fast re-deposition. For stainless steel, etching is much more effective compared to copper and it also works for {sup 210}Po.

  1. Removal of long-lived 222Rn daughters by electropolishing thin layers of stainless steel

    Science.gov (United States)

    Schnee, R. W.; Bowles, M. A.; Bunker, R.; McCabe, K.; White, J.; Cushman, P.; Pepin, M.; Guiseppe, V. E.

    2013-08-01

    Long-lived alpha and beta emitters in the 222Rn decay chain on detector surfaces may be the limiting background in many experiments attempting to detect dark matter or neutrinoless double beta decay. Removal of tens of microns of material via electropolishing has been shown to be effective at removing radon daughters implanted into material surfaces. Some applications, however, require the removal of uniform and significantly smaller thicknesses. Here, we demonstrate that electropolishing steel plates reduces the contamination efficiently, by a factor > 100. Examination of electropolished wires with a scanning electron microscope confirms that the thickness removed is reproducible and reasonably uniform. Together, these tests demonstrate the effectiveness of removal of radon daughters for a proposed low-radiation, multi-wire proportional chamber (the BetaCage), without compromising the screener's energy resolution. More generally, electropolishing thin layers of stainless steel may effectively remove radon daughters without compromising precision-machined parts.

  2. Removal of long-lived $^{222}$Rn daughters by electropolishing thin layers of stainless steel

    CERN Document Server

    Schnee, R W; Bunker, R; McCabe, K; White, J; Cushman, P; Pepin, M; Guiseppe, V E

    2014-01-01

    Long-lived alpha and beta emitters in the $^{222}$Rn decay chain on detector surfaces may be the limiting background in many experiments attempting to detect dark matter or neutrinoless double-beta decay. Removal of tens of microns of material via electropolishing has been shown to be effective at removing radon daughters implanted into material surfaces. Some applications, however, require the removal of uniform and significantly smaller thicknesses. Here, we demonstrate that electropolishing 100. Examination of electropolished wires with a scanning electron microscope confirms that the thickness removed is reproducible and reasonably uniform. Together, these tests demonstrate the effectiveness of removal of radon daughters for a proposed low-radiation, multi-wire proportional chamber (the BetaCage), without compromising the screener's energy resolution. More generally, electropolishing thin layers of stainless steel may effectively remove radon daughters without compromising precision-machined parts.

  3. Removal of long-lived Rn-222 daughters by electropolishing thin layers of stainless steel

    Science.gov (United States)

    Frascatore, J.; Schnee, R. W.; Bowles, M. A.; Bunker, R.; McCabe, K.; White, J.; Cushman, P.; Pepin, M.; Guiseppe, V. E.

    2013-10-01

    Long-lived daughter particles from the 222Rn decay chain may present a limiting background in dark matter detecting experiments. Electropolishing has proven to be an effective method at removing these daughter particles from material surfaces, particularly stainless steel. The removal of steel reduces the sample daughter contamination by a factor > 100. The total thickness removed due to electropolishing is fairly uniform, as observed by examining samples with a scanning electron microscope. Electropolishing can therefore be used for precision-machined equipment and applications which require the removal of uniform and significantly small thicknesses. Here, the relationship between thickness removed and removal of daughter contamination is studied, including corrections for systematic uncertainties produced by drifts in the digital scale calibration, alpha detector gain drifts, and grow-in of 210Po.

  4. Removal of the long-lived 222Rn daughters from copper and stainless steel surfaces

    Science.gov (United States)

    Zuzel, G.; Wójcik, M.

    2012-06-01

    Removal of the long-lived 222Rn daughters from copper and stainless steel surfaces was investigated. Etching and electropolishing were applied to discs exposed earlier to a strong radon source for 210Pb, 210Bi and 210Po deposition. Cleaning efficiency for 210Pb was tested with a n-type high purity germanium spectrometer, for 210Bi a beta spectrometer and for 210Po an alpha spectrometer was used. According to the performed measurements electropolishing removes very effectively all the isotopes from copper and stainless steel. Copper etching reduces efficiently lead and bismuth however for polonium the effect is negligible because of its fast re-deposition. For stainless steel, etching is much more effective compared to copper and it also works for 210Po.

  5. Estimated doses related to 222Rn concentration in bunker for radiotherapy and storage of radioisotopes

    International Nuclear Information System (INIS)

    It was done a survey in radiotherapy services underground hospitals and clinics of Venezuela and Paraguay in order to estimate the concentrations of radon and its possible consequences on worker occupational exposure. Passive dosimeters were used to assess nuclear traces (NTD type CR-39®). The concentration of 222Rn is determined based on the density of traces using the calibration coefficient of 1 tr/cm2 equivalent to 0,434 Bqm-3 per month of exposure. Assuming the most likely environmental conditions and the dose conversion factor equal to 9.0 x 10-6 mSv h -1 by Bqm-3, it was determined the average values and estimated the possible risks to health that are on average 3.0 mSva-1 and 150 micro risk cancer

  6. Study of radon-222 released from water during typical household activities

    International Nuclear Information System (INIS)

    Small quantities of radon-222 can be found in all ground water from natural sources as a result of decay of radium-226 both in water and the soils and soil matrix surrounding the water. Radon in drinking water has previously been considered a source of radiation exposure primarily from an ingestion standpoint. However, the EPA, Office of Radiation Programs, is investigating the potential for exposure to individuals from inhalation of gaseous radon released from water. This report describes the results of a study to determine the fraction of radon released from water during typical household activities such as clothes washing, dishwashing, showering, etc., and estimates the potential radon concentration in air and resulting working levels in structures

  7. Development of Radon-222 as Natural Tracer for Monitoring the Remediation of NAPL in the Subsurface

    International Nuclear Information System (INIS)

    Naturally occurring 222-radon in ground water can potentially be used as an in situ partitioning tracer to characterize dense nonaqueous phase liquid (DNAPL) saturations. The static method involves comparing radon concentrations in water samples from DNAPL-contaminated and non-contaminated portions of an aquifer. During a push-pull test, a known volume of test solution (radon-free water containing a conservation tracer) is first injected (''pushed'') into a well; flow is then reversed and the test solution/groundwater mixture is extracted (''pulled'') from the same well. In the presence of NAPL radon transport is retarded relative to the conservative tracer. Assuming linear equilibrium partitioning, retardation factors for radon can be used to estimate NAPL saturations.The utility of this methodology was evaluated in laboratory and field settings

  8. High-resolution ion pulse ionization chamber with air filling for the Rn-222 decays detection

    CERN Document Server

    Gavrilyuk, Yu M; Gezhaev, A M; Etezov, R A; Kazalov, V V; Kuzminov, V V; Panasenko, S I; Ratkevich, S S; Tekueva, D A; Yakimenko, S P

    2015-01-01

    The construction and characteristics of the cylindrical ion pulse ionization chamber (CIPIC) with a working volume of 3.2 L are described. The chamber is intended to register alpha-particles from the $^{222}$Rn and its daughter's decays in the filled air sample. The detector is less sensitive to electromagnetic pick-ups and mechanical noises. The digital pulse processing method is proposed to improve the energy resolution of the ion pulse ionization chamber. An energy resolution of 1.6% has been achieved for the 5.49 MeV alpha-line. The dependence of the energy resolution on high voltage and working media pressure has been investigated and the results are presented.

  9. Continuous 222Rn measurements in water to perform a hydrograph separation

    International Nuclear Information System (INIS)

    To get information about the different components of runoff before, during and after heavy rain events, micro catchments were selected to perform hydrograph separations using the radioactive noble gas 222Rn and the stable isotope 18O as natural occurring, conservative tracers. These tracers help to separate 'pre event', 'event', and 'post event' water in the total runoff. The selected micro basins are situated in the western part of Luxembourg and belong to the Attert River catchment area. Our investigations are a part of the project 'Cycleau' which is studying risk assessments in the Attert River area. By combining the databases great opportunities for comparison were realized. So far the catchment areas have been studied for two years. Continuous monitoring radon detectors were installed at selected measuring points, which were important for the different flow regimes. Along with the detectors precision thermometers, conductivity instruments, CO2-detectors, flow meter, v-notches, and automatic sampler for chemical analysis were set up. Besides the continuous measurements for 222Rn, point samples were taken for liquid scintillation analysis (LCS). Single rain events will have been sampled and measured intensively for 222Rn (LCS) and 18O in two to three days field campaigns, for a comparison of the continuous method with the 18O results and to strengthen our data by the end of march 2004. During the first year of this study instrument testing and evaluation was performed. Different radon monitor units were examined to find instruments that work best under field conditions. Additionally, separate units had to be constructed for a degassing of the solved gases out of the water, because the instruments for radon measuring were constructed for radon in air not for radon in water. A 'bubbler' had be developed that performs the degassing process. The techniques will be presented. Through stable results from our instrument developments, we observed different radon peaks

  10. RADEX: an active monitor for continuous measurement of 222Rn flux in soil

    International Nuclear Information System (INIS)

    A radon exhalation monitor, RADEX, was developed at the Environmental Measurements Laboratory. RADEX is an active radon monitor that continuously samples radon gas emanating from the soil. A hemispherical accumulator is placed on the soil and radon gas is drawn into the RADEX counter at a low, controlled flow rate. As 222Rn decays, the resulting radon daughters are focused by an electrostatic field, deposited directly onto a semiconductor detector, and counted. RADEX's ability to detect rapid changes in radon exhalation is made possible by analyzing RaA alphas with fast decay times. The pulses produced by the radon daughters are integrated hourly and are recorded. This system can operate unattended for 1 week, at which time a desiccant column must be changed. Thus, RADEX allows one to observe and to record continuously the radon flux from the soil. 8 references, 10 figures, 1 table

  11. Calibration of LR-115 for 222Rn monitoring taking into account the plateout effect.

    Science.gov (United States)

    Da Silva, A A R; Yoshimura, E M

    2003-01-01

    The dose received by people exposed to indoor radon is mainly due to radon progeny. This fact points to the establishment of techniques that access either radon and progeny together, or only radon progeny concentration. In this work a low cost and easy to use methodology is presented to determine the total indoor alpha emission concentration. It is based on passive detection using LR-115 and CR-39 detectors, taking into account the plateout effect. A calibration of LR-115 track density response was done by indoor exposure in controlled environments and dwellings, places where 222Rn and progeny concentration were measured with CR-39. The calibration factor obtained showed great dependence on the ambient condition: (0.69 +/- 0.04) cm for controlled environments and (0.43 +/- 0.03) cm for dwellings.

  12. BECK FOUMULA REVISION FOR 222Rn ESCAPE AND WATER CONTENT IN SOIL

    Institute of Scientific and Technical Information of China (English)

    姜让荣; 卢兆伦; 等

    1995-01-01

    This paper points out the limitation of Beck formula and gives a revised formula owing to the water content and 222Rn escape in soil for calculating γ radiation dose rate through the experimental fitting from 576 sets of measured values in Zhejiang Province,When the revised formula is applied to Beijing Municipality,wherer there is a great difference in the meteorology and soil conditions,the calculated average in general is only 3.5% different from that measured;those of every position deviate only2.1% averagely;and their dispersion is in the experimental errors.Therefore,the revised formula possesses a high reliability and a broad suitability,and is an effective method to estimate the γ radiation dose rate onb the land.

  13. Establishment of the {sup 222}Rn traceability chain with the Romanian standard system

    Energy Technology Data Exchange (ETDEWEB)

    Sahagia, M., E-mail: msahagia@nipne.r [' Horia Hulubei' National Institute of R and D for Physics and Nuclear Engineering, IFIN-HH, POB MG-6, 077125 Bucharest (Romania); Luca, A.; Waetjen, A.C.; Antohe, A.; Ivan, C. [' Horia Hulubei' National Institute of R and D for Physics and Nuclear Engineering, IFIN-HH, POB MG-6, 077125 Bucharest (Romania); Varlam, C.; Faurescu, I. [National Institute of R and D for Cryogenic and Isotopic Technologies, ICSI Rm. Valcea (Romania); Cassette, P. [LNE-CEA, LIST, Laboratoire National Henri Becquerel, F-91191 Gif-sur-Yvette (France)

    2011-03-01

    This paper presents the results obtained in the establishment of the upper level of the traceability chain, primary and secondary {sup 222}Rn measurements, with the standard system realized at IFIN-HH, Romania. The following subjects are presented: (i) the principle of establishing the traceability chain; (ii) the setting up of the final metallic system for the radon standardization and the experimental method; (iii) results obtained in the realization of the traceability chain, by absolute radon standardization with the liquid scintillation counting method (LSC) and relative measurements of activity, using the HPGe gamma-ray spectrometry method and the CENTRONIC IG12/20A ionization chamber, and its validation. The final purpose of the work is to calibrate adequately the secondary standard systems, HPGe spectrometer and ionization chamber, for using them in the measurement of the working standards, various types of recipients containing radon gas, prepared in the laboratory with the radon system.

  14. Numerical modelling of radon-222 entry into houses: An outline of techniques and results

    DEFF Research Database (Denmark)

    Andersen, C.E.

    2001-01-01

    Numerical modelling is a powerful tool for studies of soil gas and radon-222 entry into houses. It is the purpose of this paper to review some main techniques and results. In the past, modelling has focused on Darcy flow of soil gas (driven by indoor–outdoor pressure differences) and combined...... diffusive and advective transport of radon. Models of different complexity have been used. The simpler ones are finite-difference models with one or two spatial dimensions. The more complex models allow for full three-dimensional and time dependency. Advanced features include: soil heterogeneity, anisotropy......, fractures, moisture, non-uniform soil temperature, non-Darcy flow of gas, and flow caused by changes in the atmospheric pressure. Numerical models can be used to estimate the importance of specific factors for radon entry. Models are also helpful when results obtained in special laboratory or test structure...

  15. Improved green-light-emitting pyrotechnic formulations based on tris(2,2,2-trinitroethyl)borate and boron carbide.

    Science.gov (United States)

    Klapötke, Thomas M; Krumm, Burkhard; Rusan, Magdalena; Sabatini, Jesse J

    2014-08-28

    Green-light-emitting pyrotechnic compositions based on tris(2,2,2-trinitroethyl)borate (TNEB) and boron carbide have been investigated. The best performing formulations were found to be insensitive to various ignition stimuli, and exhibited very high spectral purities and luminosities compared to previously reported green-light-emitting formulations.

  16. Phosphogypsum as an alternative building material: preliminary modeling and simulation of radon-222 exhalation from blocks and indoor accumulation

    International Nuclear Information System (INIS)

    Phosphogypsum is a by-product from the phosphate fertilizer industry and its large-scale utilization as an alternative construction material copes with radiological issues related to radon-222. Zero-order models for radon-222 exhalation from phosphogypsum building blocks and its time-varying accumulation in closed domains (e.g. indoor accumulation) presume homogeneous distribution of radon-222 throughout the enclosure. Having in mind radiological protection design, exhalation characterization of a block sample is a valuable parameter for the corresponding building performance simulation and it can be accomplished by placing a test block inside a test chamber together with a suitable nuclear detector (their relative positioning depends on the chamber geometry). As breakdown of the uniform concentration hypothesis is likely to occur, this preliminary work numerically investigates such model oversimplification. Along with emanation and decay processes, the present mathematical model assumes time-dependent two-dimensional diffusion-dominant mass transfer in a domain containing a sample of porous material, namely the phosphogypsum block of finite thickness. Conversely, as the test chamber is quite small and air-tight closed, convective mass transfer is neglected. Numerically simulated results have confirmed that a non-uniform radon-222 distribution takes place, which can obviously influence the position of the nuclear detector (or its primary element), thus affecting its readings. (author)

  17. Estimation of submarine groundwater discharge and associated nutrient fluxes in eastern Laizhou Bay, China using 222Rn

    Science.gov (United States)

    Zhang, Yan; Li, Hailong; Wang, Xuejing; Zheng, Chunmiao; Wang, Chaoyue; Xiao, Kai; Wan, Li; Wang, Xusheng; Jiang, Xiaowei; Guo, Huaming

    2016-02-01

    There is increasing evidence that the inputs of nutrients to the Bohai Sea are closely related to submarine groundwater discharge (SGD). In this study, the naturally occurring isotope of radon (222Rn) was used as a tracer to assess SGD in eastern Laizhou Bay. The 222Rn concentration during a tidal period was measured continuously and a mass balance model that included atmospheric loss, tidal effects, mixing loss, diffusion from sediments, and SGD was established. The model budget indicated that 222Rn flux attributed to SGD accounted for 58.3% of the total tracer input to the study area. The time-series of 222Rn revealed that the SGD flux ranged from 6.64 to 7.21 cm d-1, with an average of 6.93 cm d-1, in September 2014. The estimated SGD flux is reasonable compared with those previously estimated in other studies by direct measurement methods, hydrogeological simulation and geochemical tracers. This result, as well as the current understanding of nutrients dissolved in groundwater, confirms the importance of SGD in delivering nutrients to Laizhou Bay and possible impact on marine ecological environment.

  18. Bethe Ansatz for Supersymmetric Model Constructed from Uq[osp(2|2)(2)] R-Matrix

    Institute of Scientific and Technical Information of China (English)

    YANG Wen-Li; ZHEN Yi

    2001-01-01

    Using the algebraic Bethe ansatz method, we obtain the eigenvalues of transfer matrix of the supersymmetric model constructed from the R-matrix of the twisted affine superalgebra Uq[osp(2|2)(2)] in periodic boundary condition and twisted boundary condition.``

  19. Elevation of miR-221 and -222 in the internal mammary arteries of diabetic subjects and normalization with metformin.

    Science.gov (United States)

    Coleman, Chasity B; Lightell, Daniel J; Moss, Stephanie C; Bates, Michael; Parrino, Patrick E; Woods, T Cooper

    2013-07-15

    Diabetes is a major risk factor for cardiovascular disease and is associated with increased intimal thickening and accelerated vascular smooth muscle cell (VSMC) proliferation. We measured the expression of two microRNAs that promote intimal thickening, miR-221/222, and mRNA encoding a downstream target, p27(Kip1), in internal mammary artery (IMA) segments collected from 37 subjects undergoing coronary artery bypass grafting. The segments were stratified into three groups: non-diabetic subjects (ND), diabetic subjects not on metformin (DMMet-), and diabetic subjects on metformin (DMMet+). The DMMet- group exhibited a significant increase in miR-221/222 and decrease in p27(Kip1) mRNA compared to both the ND and DMMet+ groups. miR-221/222 levels inversely correlated with metformin dose. VSMCs isolated from the IMAs of the DMMet- group proliferate at a faster rate than those of the ND and DMMet+ groups. Further studies into the importance of miR-221/222 in the increased intimal thickening observed in diabetic subjects is warranted. PMID:23648338

  20. 20 CFR 222.10 - When determinations of relationship as wife, husband, widow or widower of employee are made.

    Science.gov (United States)

    2010-04-01

    ... RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Wife, Husband, or Widow(er) § 222.10 When determinations of relationship as wife, husband, widow or widower of... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When determinations of relationship as...

  1. 20 CFR 222.40 - When determinations of relationship are made for parent, grandchild, brother or sister.

    Science.gov (United States)

    2010-04-01

    ... RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222.40 When determinations of relationship are made for parent, grandchild... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When determinations of relationship are...

  2. 34 CFR 222.13 - What overpayments are not eligible for forgiveness under section 8012 of the Act?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What overpayments are not eligible for forgiveness... PROGRAMS General § 222.13 What overpayments are not eligible for forgiveness under section 8012 of the Act? The Secretary does not consider the following overpayments to be eligible for forgiveness...

  3. 34 CFR 222.12 - What overpayments are eligible for forgiveness under section 8012 of the Act?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What overpayments are eligible for forgiveness under... § 222.12 What overpayments are eligible for forgiveness under section 8012 of the Act? (a) The Secretary considers as eligible for forgiveness under section 8012 of the Act (“eligible overpayment”) any...

  4. National survey on the natural radioactivity and Rn-222 exhalation rate of building materials in the Netherlands

    NARCIS (Netherlands)

    de Jong, P.; van Dijk, W.; van der Graaf, E.R.; de Groot, A.V.

    2006-01-01

    The present study reports on results of a nationwide survey on the natural radioactivity concentrations and Rn-222 exhalation rates of the prevailing building materials in the Netherlands. In total 100 samples were taken and analyzed for the activity concentrations of Ra-226, Ra-228, Th-228, and K-4

  5. 12 CFR Appendix E to Part 222 - Interagency Guidelines Concerning the Accuracy and Integrity of Information Furnished to Consumer...

    Science.gov (United States)

    2010-01-01

    ... furnished to consumer reporting agencies; consider whether new, additional, or different policies and... accuracy and integrity of the information it provides to consumer reporting agencies; and whether new... and Integrity of Information Furnished to Consumer Reporting Agencies E Appendix E to Part 222...

  6. Characterizing a shallow groundwater system beneath irrigated sugarcane with electrical resistivity and radon (Rn-222), Puunene, Hawaii

    Science.gov (United States)

    In this study, we use a combination of electrical resistivity profiling and radon (222Rn) measurements to characterize a shallow groundwater system beneath the last remaining, large-scale sugarcane plantation on Maui, Hawaii. Hawaiian Commercial & Sugar Company has continuously operated a sugarcane...

  7. 36 CFR 222.8 - Cooperation in control of estray or unbranded livestock, animal diseases, noxious farm weeds, and...

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Cooperation in control of... Grazing and Livestock Use on the National Forest System § 222.8 Cooperation in control of estray or... boards in control of estray and unbranded livestock to the extent it does not conflict with the Wild...

  8. 12 CFR 222.30 - Obtaining or using medical information in connection with a determination of eligibility for credit.

    Science.gov (United States)

    2010-01-01

    ... history information in his credit report, the creditor may consider such medical information in evaluating... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Obtaining or using medical information in... (REGULATION V) Medical Information § 222.30 Obtaining or using medical information in connection with...

  9. 48 CFR 252.222-7001 - Right of first refusal of employment-Closure of military installations.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Right of first refusal of... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.222-7001 Right of first refusal...: Right of First Refusal of Employment—Closure of Military Installations (APR 1992) (a) The...

  10. Sensitivity of LR115 detector in diffusion chamber to {sup 222}Rn in the presence of {sup 220}Rn

    Energy Technology Data Exchange (ETDEWEB)

    Koo, V.S.Y.; Yip, C.W.Y.; Ho, J.P.Y.; Nikezic, D.; Yu, K.N. E-mail: peter.yu@cityu.edu.hk

    2002-06-01

    Determination has been made of the sensitivity of LR115 type 2-track detectors (in units of m) to {sup 222}Rn, measured in the presence of {sup 220}Rn. Measurements have been made by means of a widely used diffusion chamber while Monte Carlo simulations have also been conducted. The experimentally derived sensitivities for {sup 222}Rn and {sup 220}Rn were found to be 0.470{+-}0.022 and 0.486{+-}0.042 m, respectively. For Monte Carlo simulations, the sensitivities to {sup 222}Rn gas were found to range from 0.618x10{sup -2} m (assuming that all {sup 218}Po progeny decay before deposition onto the internal walls of the diffusion chamber) to 0.405x10{sup -2} m (assuming that all {sup 218}Po progeny are deposited on the internal walls of the same containment vessel before decaying). The sensitivity to {sup 220}Rn gas of 0.465x10{sup -2} m found from Monte Carlo simulations agrees to within uncertainty with experimental findings. The experimentally derived sensitivity value for {sup 222}Rn indicates that 30% of the {sup 218}Po progeny decay before deposition onto the internal walls of the diffusion chamber.

  11. Persistence of radon-222 flux during monsoon at a geothermal zone in Nepal

    Energy Technology Data Exchange (ETDEWEB)

    Girault, Frederic [Equipe de Geomagnetisme, Institut de Physique du Globe de Paris, UMR-7154 and Universite Paris-Diderot, 4 place Jussieu, F-75005 Paris (France)], E-mail: girault@ipgp.jussieu.fr; Koirala, Bharat Prasad [National Seismic Centre, Department of Mines and Geology, Lainchaur, Kathmandu (Nepal); Perrier, Frederic [Equipe de Geomagnetisme, Institut de Physique du Globe de Paris, UMR-7154 and Universite Paris-Diderot, 4 place Jussieu, F-75005 Paris (France); Richon, Patrick [CEA, DAM, DIF, F-91297 Arpajon (France); Equipe de Geologie des Systemes Volcaniques, Institut de Physique du Globe de Paris, UMR-7154, 4 place Jussieu, F-75005 Paris (France); Rajaure, Sudhir [National Seismic Centre, Department of Mines and Geology, Lainchaur, Kathmandu (Nepal)

    2009-11-15

    The Syabru-Bensi hydrothermal zone, Langtang region (Nepal), is characterized by high radon-222 and CO{sub 2} discharge. Seasonal variations of gas fluxes were studied on a reference transect in a newly discovered gas discharge zone. Radon-222 and CO{sub 2} fluxes were measured with the accumulation chamber technique, coupled with the scintillation flask method for radon. In the reference transect, fluxes reach exceptional mean values, as high as 8700 {+-} 1500 g m{sup -2} d{sup -1} for CO{sub 2} and 3400 {+-} 100 x 10{sup -3} Bq m{sup -2} s{sup -1} for radon. Gases fluxes were measured in September 2007 during the monsoon and during the dry winter season, in December 2007 to January 2008 and in December 2008 to January 2009. Contrary to expectations, radon and its carrier gas fluxes were similar during both seasons. The integrated flux along this transect was approximately the same for radon, with a small increase of 11 {+-} 4% during the wet season, whereas it was reduced by 38 {+-} 5% during the monsoon for CO{sub 2}. In order to account for the persistence of the high gas emissions during monsoon, watering experiments have been performed at selected radon measurement points. After watering, radon flux decreased within 5 min by a factor of 2-7 depending on the point. Subsequently, it returned to its original value, firstly, by an initial partial recovery within 3-4 h, followed by a slow relaxation, lasting around 10 h and possibly superimposed by diurnal variations. Monsoon, in this part of the Himalayas, proceeds generally by brutal rainfall events separated by two- or three-day lapses. Thus, the recovery ability shown in the watering experiments accounts for the observed long-term persistence of gas discharge. This persistence is an important asset for long-term monitoring, for example to study possible temporal variations associated with stress accumulation and release.

  12. Measurement of (222)Rn by absorption in plastic scintillators and alpha/beta pulse shape discrimination.

    Science.gov (United States)

    Mitev, Krasimir K

    2016-04-01

    This work demonstrates that common plastic scintillators like BC-400, EJ-200 and SCSF-81 absorb radon and their scintillation pulse decay times are different for alpha- and beta-particles. This allows the application of pulse shape analysis for separation of the pulses of alpha- and beta-particles emitted by the absorbed radon and its progeny. It is shown that after pulse shape discrimination of beta-particles' pulses, the energy resolution of BC-400 and EJ-200 alpha spectra is sufficient to separate the peaks of (222)Rn, (218)Po and (214)Po and allows (222)Rn measurements that are unaffected by the presence of thoron ((220)Rn) in the environment. The alpha energy resolution of SCSF-81 in the experiments degrades due to imperfect collection of the light emitted inside the scintillating fibers. The experiments with plastic scintillation microspheres (PSM) confirm previous findings of other researchers that PSM have alpha-/beta-discrimination properties and show suitability for radon measurements. The diffusion length of radon in BC-400 and EJ-200 is determined. The pilot experiments show that the plastic scintillators are suitable for radon-in-soil-gas measurements. Overall, the results of this work suggest that it is possible to develop a new type of radon measurement instruments which employ absorption in plastic scintillators, pulse-shape discrimination and analysis of the alpha spectra. Such instruments can be very compact and can perform continuous, real-time radon measurements and thoron detection. They can find applications in various fields from radiation protection to earth sciences. PMID:26851823

  13. Persistence of radon-222 flux during monsoon at a geothermal zone in Nepal

    International Nuclear Information System (INIS)

    The Syabru-Bensi hydrothermal zone, Langtang region (Nepal), is characterized by high radon-222 and CO2 discharge. Seasonal variations of gas fluxes were studied on a reference transect in a newly discovered gas discharge zone. Radon-222 and CO2 fluxes were measured with the accumulation chamber technique, coupled with the scintillation flask method for radon. In the reference transect, fluxes reach exceptional mean values, as high as 8700 ± 1500 g m-2 d-1 for CO2 and 3400 ± 100 x 10-3 Bq m-2 s-1 for radon. Gases fluxes were measured in September 2007 during the monsoon and during the dry winter season, in December 2007 to January 2008 and in December 2008 to January 2009. Contrary to expectations, radon and its carrier gas fluxes were similar during both seasons. The integrated flux along this transect was approximately the same for radon, with a small increase of 11 ± 4% during the wet season, whereas it was reduced by 38 ± 5% during the monsoon for CO2. In order to account for the persistence of the high gas emissions during monsoon, watering experiments have been performed at selected radon measurement points. After watering, radon flux decreased within 5 min by a factor of 2-7 depending on the point. Subsequently, it returned to its original value, firstly, by an initial partial recovery within 3-4 h, followed by a slow relaxation, lasting around 10 h and possibly superimposed by diurnal variations. Monsoon, in this part of the Himalayas, proceeds generally by brutal rainfall events separated by two- or three-day lapses. Thus, the recovery ability shown in the watering experiments accounts for the observed long-term persistence of gas discharge. This persistence is an important asset for long-term monitoring, for example to study possible temporal variations associated with stress accumulation and release.

  14. Radon (222Rn) in ground water of fractured rocks: A diffusion/ion exchange model

    Science.gov (United States)

    Wood, W.W.; Kraemer, T.F.; Shapiro, A.

    2004-01-01

    Ground waters from fractured igneous and high-grade sialic metamorphic rocks frequently have elevated activity of dissolved radon (222Rn). A chemically based model is proposed whereby radium (226Ra) from the decay of uranium (238U) diffuses through the primary porosity of the rock to the water-transmitting fracture where it is sorbed on weathering products. Sorption of 226Ra on the fracture surface maintains an activity gradient in the rock matrix, ensuring a continuous supply of 226Ra to fracture surfaces. As a result of the relatively long half-life of 226Ra (1601 years), significant activity can accumulate on fracture surfaces. The proximity of this sorbed 226Ra to the active ground water flow system allows its decay progeny 222Rn to enter directly into the water. Laboratory analyses of primary porosity and diffusion coefficients of the rock matrix, radon emanation, and ion exchange at fracture surfaces are consistent with the requirements of a diffusion/ion- exchange model. A dipole-brine injection/withdrawal experiment conducted between bedrock boreholes in the high-grade metamorphic and granite rocks at the Hubbard Brook Experimental Forest, Grafton County, New Hampshire, United States (42??56???N, 71??43???W) shows a large activity of 226Ra exchanged from fracture surfaces by a magnesium brine. The 226Ra activity removed by the exchange process is 34 times greater than that of 238U activity. These observations are consistent with the diffusion/ion-exchange model. Elutriate isotopic ratios of 223Ra/226Ra and 238U/226Ra are also consistent with the proposed chemically based diffusion/ion-exchange model.

  15. Evaluation of radon-222 concentrations levels at workplaces of Curitiba, PR, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Del Claro, Flavia; Paschuk, Sergei A.; Correa, Janine N.; Kappke, Jaqueline; Perna, Allan F.N.; Reque, Marilson; Martins Neto, Manoel R., E-mail: flavia_delclaro@yahoo.com.br, E-mail: spaschuk@gmail.com [Universidade Tecnologica Federal do Parana (UTFPR), Curitiba - PR (Brazil); Denyak, Valeriy, E-mail: denyak@gmail.com [Instituto de Pesquisa Pele Pequeno Principe (FPP), Curitiba - PR (Brazil)

    2013-07-01

    The radon is noble radioactive gas, which when inhaled and undergoing spontaneous decay emits alpha particles that interacting with the cells of biological tissue stimulates the development of lung cancer. The isotope {sup 222}Rn is responsible for approximately half of the effective dose received by the population from natural radiation sources. Current work is focused at the evaluation of the radon concentration levels in air of different workplaces at Curitiba-PR. For this purpose 126 track-etched detectors CR-39 were mounted inside the diffusion chambers that were distributed at workplaces of three enterprises environments for a period of three months approximately. The diffusion chambers were protected by a borosilicate glass fiber filters. After the exposition in air the detectors were submitted to chemical etching using a solution of 6.25M NaOH at 70°C during 14 hours. Such chemical treatment enables to count alpha particle track using an optical microscope with 100x objective magnification. The density of alpha particle tracks in CR-39 was converted to the radon activity concentration in air using the results of previous calibration performed at the National Institute of Radiological Sciences (NIRS) in Japan. Obtained results show that the concentration of {sup 222}Rn in air at studied workplaces varied from 16±2 Bq/m³ to 78±9 Bq/m³. These values are considered within the limits established by international regulatory agencies such as EPA and ICRP, which consider as normal the radon activity up to 200 Bq/m³ and 148 Bq/m³, respectively. (author)

  16. Quantification of Submarine Groundwater Discharge Using a Radon (222-Rn) Mass Balance and Hydrogeological Modelling

    Science.gov (United States)

    Petermann, Eric; Stollberg, Reiner; Scholten, Jan; Knöller, Kay; Schubert, Michael

    2016-04-01

    Apart from river and surface water runoff subsurface discharge of groundwater plays a key role in coastal water and matter budgets. Two major forms of submarine groundwater discharge (SGD) can be distinguished: (i) pure freshwater discharge from continental aquifers that are connected to the coastal sea driven by a positive hydraulic gradient (fresh SGD) and (ii) re-circulation of seawater that has penetrated permeable coastal sediments (re-circulated SGD), e.g. driven by tidal pumping. The localization of SGD zones and the quantification of SGD fluxes is of high interest for coastal water management due to potential threats related to SGD, namely (i) the detrimental impact of discharging nutrient- or contaminant-laden groundwater on coastal seawater quality, an aspect that is of relevance along coastlines which are impacted by agriculture, industry or intense urbanization, and (ii) the loss of freshwater to the ocean, an issue that is of major relevance in all coastal areas with (seasonally) limited freshwater availability. In this work, we discuss estimates for the total (fresh + re-circulated) SGD fluxes derived from a mass balance of the radioactive noble gas radon (222-Rn) with estimates of fresh SGD fluxes derived by hydrogeological modelling. The precision of the mass balance results depends on the adequate determination of the mass balance source and sink terms. These terms are calculated based on field observations of environmental tracers (salinity, δ18O, 222-Rn, 223-Ra, 224-Ra, 226-Ra) in seawater and porewater, as well as on meteorological data. The numerical hydrogeological model estimates groundwater flow based on groundwater monitoring data, river flow data, groundwater recharge estimates, tidal dynamics, and density effects along the freshwater/seawater interface. We compare these two independent methodological approaches of SGD flux estimation, discuss results regarding their relevance for the regional water balance and reason the implications of

  17. Controls on {sup 222}Rn variations in a fractured crystalline rock aquifer evaluated using aquifer tests and geophysical logging

    Energy Technology Data Exchange (ETDEWEB)

    Folger, P.F. [Office of Senator Pete V. Domenici, Washington, DC (United States)]|[Colorado School of Mines, Golden, CO (United States). Dept. of Geology and Geologic Engineering; Poeter, E. [Colorado School of Mines, Golden, CO (United States). Dept. of Geology and Geologic Engineering; Wanty, R.B.; Frishman, D.; Day, W.

    1996-03-01

    Concentrations of {sup 222}Rn in ground water may vary considerably within megascopically homogeneous rocks over relatively short distances. Calculations indicate that different hydraulic apertures of water-bearing fractures may account for variations in dissolved {sup 222}Rn concentration measured in domestic water wells completed in fractured Pikes Peak Granite, assuming that all other factors influencing dissolved {sup 222}Rn concentrations are constant. Concentrations of dissolved {sup 222}Rn range from 124 to 840 kBq/m{sup 3} [3,360 to 22,700 picocuries/liter] within a 2.5 km{sup 2} well field. Aquifer tests show that transmissivities range from 0.072 to 160 m{sup 2}/day within the well field. Acoustic televiewer and heat-pulse flow meter logging of four wells reveals that, despite tens to hundreds of fractures that intersect each well, a single fracture supplies all the flow to three wells, and one fracture provides 65% of the flow to the fourth well. Type-curve interpretation of early-time data from aquifer tests reveals classic half-slope behavior on log-log plots of drawdown versus time for two wells, suggesting linear flow to a single fracture. Drawdown versus time for the other two wells indicates radial or pseudo-radial flow, which suggests a higher degree of fracture interconnectivity near those boreholes. Hydraulic apertures calculated using the cubic law are 0.024 and 0.038 cm for producing fractures in the first hydraulically connected well pair and 0.011 and 0.020 cm for flowing fractures in the second well pair. Assuming uniform distribution of {sup 226}Ra along fracture walls and long residence time of water relative to {sup 222}Rn decay, the ratio of fracture apertures should equal the inverse ratio of {sup 222}Rn concentration in each well. Differences in {sup 222}Rn concentration between wells in the hydraulically connected pairs can be attributed solely to differences in hydraulic aperture.

  18. Development of method for quantification of 222Rn exhalation ratio at radioactive waste dam and soil study as mitigator material

    International Nuclear Information System (INIS)

    The Brazilian uranium mining company (INB) processed 2.32 106 tons of uranium ore in its ore treatment unit (UTM - Caldas), located in the Pocos de Caldas plateau. During 16 years of operation, this unit discarded 2.39 106 tons of solid waste in a tailing dam, with an average activity concentration of 226Ra of 7311 ± 184 Bq kg-1. Most of the atoms of 222Rn generated from the radioactive waste of the tailing dam remain bounded to the mineral structure. However, a fraction of these atoms can be released from the mineral structure and then emanate. Reaching the porous space of the waste piles, the 222Rn moves towards the interface waste-atmosphere, exhaling into the atmosphere. The featuring properties of the 222Rn transport and the biological damage caused by its progeny transform this small chain of radionuclides into a scourge of nature. Because of that, the dry area of the tailing dam was the scope of this work. A methodology was developed for quantifying the exhalation rate of 222Rn. Moreover, the soil from its surroundings was experimentally evaluated as a cover material to reduce the exhalation of 222Rn. A collector of 222Rn was developed, being denominated 607. This collector was proved to be exact and precise after laboratory tests, when a standard for 222Rn exhalation was prepared with caldasite, an uranium ore with high concentration of 226Ra (26611 ± 581 Bq kg-1), crushed to the granulometric interval from 1.168 mm to 0.589 mm. The results of 222Rn exhalation rate using the collector 607 were not influenced by the adsorption of water steam, considering sampling periods lower than 5 days and mass of water steam lower than 7 g. Sampling for measuring 222Rn exhalation rates in the dry area of the tailing dam was carried out using the collector 607, following the experimental design established by the United States Environmental Protection Agency (US EPA). The average exhalation rate in the west part of the tailing dam was 1.30 ± 1.24 Bq m-2 s-1 in the

  19. Role of miR-222-3p in c-Src-Mediated Regulation of Osteoclastogenesis

    Directory of Open Access Journals (Sweden)

    Shinya Takigawa

    2016-02-01

    Full Text Available MicroRNAs (miRNAs are small non-coding RNAs that play a mostly post-transcriptional regulatory role in gene expression. Using RAW264.7 pre-osteoclast cells and genome-wide expression analysis, we identified a set of miRNAs that are involved in osteoclastogenesis. Based on in silico analysis, we specifically focused on miR-222-3p and evaluated its role in osteoclastogenesis. The results show that the inhibitor of miR-222-3p upregulated the mRNA levels of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1 and tartrate-resistant acid phosphatase (TRAP, while its mimicking agent downregulated their mRNA levels. Western blot analysis showed that its inhibitor increased the protein levels of TRAP and cathepsin K, while its mimicking agent decreased their levels. Genome-wide mRNA expression analysis in the presence and absence of receptor activator of nuclear factor κ-B ligand (RANKL predicted c-Src as a potential regulatory target of miR-222-3p. Live cell imaging using a fluorescence resonance energy transfer (FRET technique revealed that miR-222-3p acted as an inhibitor of c-Src activity, and a partial silencing of c-Src suppressed RANKL-induced expression of TRAP and cathepsin K, as well as the number of multi-nucleated osteoclasts and their pit formation. Collectively, the study herein demonstrates that miR-222-3p serves as an inhibitor of osteoclastogenesis and c-Src mediates its inhibition of cathepsin K and TRAP.

  20. Effect of anaesthetics MS-222 and clove oil on blood biochemical parameters of juvenile Siberian sturgeon (Acipenser baerii)

    Science.gov (United States)

    Feng, G.; Zhuang, P.; Zhang, L.; Kynard, B.; Shi, X.; Duan, M.; Liu, J.; Huang, X.

    2011-01-01

    The effects of MS-222 and clove oil on blood biochemical parameters of juvenile Siberian sturgeon (Acipenser baerii) were studied. MS-222 caused higher glucose (GLU) concentrations in anaesthetic test groups than for the control group. Triglyceride (TGL) concentrations of fish in the 140 and 160mgL-1 groups were also significantly higher than those of other groups. Alanine aminotransferase (ALT) activity in the 140mgL-1 group was significantly higher than the level in 80, 100 and 120mgL-1 groups. Aspartate aminotransferase (AST) activity in the 140mgL-1 group was significantly higher than those in the 100 and 120mgL-1 groups. Levels of total protein (TP), cholesterol (CHOL) and alkaline phosphatase (ALP) in anaesthetic test groups were not significantly influenced by MS-222. Clove oil did not have significant effects on levels of GLU, TP, CHOL, ALT and ALP. TGL concentration of fish exposed to 180mgL-1 clove oil was significantly higher than those of the rest anaesthetic groups. AST activities of fish exposed to 120, 150 and 180mgL-1 were significantly higher than those of 60 and 90mgL-1. Overall, TGL and AST could be potentially used as indicators of anaesthetic stress for juvenile Siberian sturgeon. Based on blood biochemical parameters, the appropriate anaesthetic concentrations of MS-222 and clove oil were 80-120mgL-1 and 60-90mgL-1, respectively. Clove oil was a promising alternative to MS-222. ?? 2011 Blackwell Verlag, Berlin.

  1. Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226

    Directory of Open Access Journals (Sweden)

    Hastie CJ

    2006-04-01

    Full Text Available Abstract Background Glycogen Synthase Kinase-3 (GSK3 activity is repressed following insulin treatment of cells. Pharmacological inhibition of GSK3 mimics the effect of insulin on Phosphoenolpyruvate Carboxykinase (PEPCK, Glucose-6 Phosphatase (G6Pase and IGF binding protein-1 (IGFBP1 gene expression. CAAT/enhancer binding protein alpha (C/EBPα regulates these gene promoters in liver and is phosphorylated on two residues (T222/T226 by GSK3, although the functional outcome of the phosphorylation has not been established. We aimed to establish whether CEBPα is a link between GSK3 and these gene promoters. Results C/EBPα represses the IGFBP1 thymine-rich insulin response element (TIRE, but mutation of T222 or T226 of C/EBPα to non-phosphorylatable alanines has no effect on C/EBPα activity in liver cells (towards the TIRE or a consensus C/EBP binding sequence. Phosphorylation of T222/T226 is decreased by GSK3 inhibition, suggesting GSK3 does phosphorylate T222/226 in intact cells. However, phosphorylation was not altered by treatment of liver cells with insulin. Meanwhile C/EBPα activity in 3T3 L1 preadipocytes was enhanced by mutation of T222/T226 and/or S230 to alanine residues. Finally, we demonstrate that C/EBPα is a very poor substrate for GSK3 in vitro and in cells. Conclusion The work demonstrates an important role for this domain in the regulation of C/EBPα activity in adipocytes but not hepatocytes, however GSK3 phosphorylation of these residues does not mediate regulation of this C/EBP activity. In short, we find no evidence that C/EBPα activity is regulated by direct phosphorylation by GSK3.

  2. Lysine at position 222 of the goat prion protein inhibits the binding of monoclonal antibody F99/97.6.1.

    Science.gov (United States)

    Mazza, Maria; Guglielmetti, Chiara; Pagano, Marianna; Sciuto, Simona; Ingravalle, Francesco; Martucci, Francesca; Caramelli, Maria; Acutis, Pier Luigi

    2012-09-01

    Prion protein (PrP) is encoded by the PRNP gene, which is highly polymorphic in goats, with polymorphisms encoding amino acid substitutions at the protein level. In the current study, the reactivity of monoclonal antibody (mAb) F99/97.6.1 in binding PrP from goats polymorphic at PRNP codon 222 was investigated. Nervous tissue from 30 scrapie-negative goats with 3 different genotypes (222Q/Q, 222Q/K, and 222K/K) was analyzed by Western blot using mAbs P4 and F99/97.6.1. Although PrP was detected in all 30 samples by mAb P4, detection of PrP by mAb F99/97.6.1 was limited to 222Q/Q (12/12). No PrP was detected by mAb F99/97.6.1 in the 222K/K samples (n = 6), and the signal intensity of mAb F99/97.6.1 for PrP was lower for the 222Q/K samples (12/12 samples). To further investigate these results, additional Western blot analyses were performed, and the PrP signals detected by mAbs F99/97.6.1 and SAF84 were then quantified. The mean F99/SAF84 ratio (± standard deviation) calculated for the 222Q/Q group was 0.73 ± 1.26, and the mean for the 222Q/K group was 0.27 ± 1.31. Statistical analysis of these values evidenced statistically significant differences between the 222Q/Q and 222Q/K samples. The results of the study thus revealed an inhibition by lysine at position 222 on the binding of mAb F99/97.6.1 to goat PrP. This has implications for the use of mAb F99/97.6.1 for diagnostic purposes. Because the 222K allele could be a target for genetic selection in goats, the differential reactivity of mAb F99/97.6.1 could be exploited with a genotyping test setup. PMID:22914824

  3. Contribution of (222)Rn-bearing water to indoor radon and indoor air quality assessment in hot spring hotels of Guangdong, China.

    Science.gov (United States)

    Song, Gang; Wang, Xinming; Chen, Diyun; Chen, Yongheng

    2011-04-01

    This study investigates the contribution of radon ((222)Rn)-bearing water to indoor (222)Rn in thermal baths. The (222)Rn concentrations in air were monitored in the bathroom and the bedroom. Particulate matter (PM, both PM(10) and PM(2.5)) and carbon dioxide (CO(2)) were also monitored with portable analyzers. The bathrooms were supplied with hot spring water containing 66-260 kBq m(-3) of (222)Rn. The results show that the spray of hot spring water from the bath spouts is the dominant mechanism by which (222)Rn is released into the air of the bathroom, and then it diffuses into the bedroom. Average (222)Rn level was 110-410% higher in the bedrooms and 510-1200% higher in the bathrooms compared to the corresponding average levels when there was no use of hot spring water. The indoor (222)Rn levels were influenced by the (222)Rn concentrations in the hot spring water and the bathing times. The average (222)Rn transfer coefficients from water to air were 6.2 × 10(-4)-4.1 × 10(-3). The 24-h average levels of CO(2) and PM(10) in the hotel rooms were 89% and 22% higher than the present Indoor Air Quality (IAQ) standard of China. The main particle pollutant in the hotel rooms was PM(2.5). Radon and PM(10) levels in some hotel rooms were at much higher concentrations than guideline levels, and thus the potential health risks to tourists and especially to the hotel workers should be of great concern, and measures should be taken to lower inhalation exposure to these air pollutants.

  4. Down-regulation of MicroRNAs 222/221 in Acute Myelogenous Leukemia with Deranged Core-Binding Factor Subunits

    Directory of Open Access Journals (Sweden)

    Matteo Brioschi

    2010-11-01

    Full Text Available Core-binding factor leukemia (CBFL is a subgroup of acutemyeloid leukemia (AML characterized by genetic mutations involving the subunits of the core-binding factor (CBF. The leukemogenesis model for CBFL posits that one, or more, gene mutations inducing increased cell proliferation and/or inhibition of apoptosis cooperate with CBF mutations for leukemia development. One of the most commonmutations associated with CBF mutations involves the KIT receptor. A high expression of KIT is a hallmark of a high proportion of CBFL. Previous studies indicate that microRNA (MIR 222/221 targets the 3′ untranslated region of the KIT messenger RNA and our observation that AML1 can bind the MIR-222/221 promoter, we hypothesized that MIR-222/221 represents the link between CBF and KIT. Here, we show that MIR-222/221 expression is upregulated after myeloid differentiation of normal bone marrow AC133+ stem progenitor cells. CBFL blasts with either t(8;21 or inv(16 CBF rearrangements with high expression levels of KIT (CD117 display a significantly lower level of MIR-222/221 expression than non-CBFL blasts. Consistently, we found that the t(8;21 AML1-MTG8 fusion protein binds the MIR-222/221 promoter and induces transcriptional repression of a MIR-222/221-LUC reporter. Because of the highly conserved sequence homology, we demonstrated concomitant MIR-222/221 down-regulation and KIT up-regulation in the 32D/WT1 mouse cell model carrying the AML1-MTG16 fusion protein. This study provides the first hint that CBFL-associated fusion proteins may lead to up-regulation of the KIT receptor by down-regulating MIR-222/221, thus explaining the concomitant occurrence of CBF genetic rearrangements and overexpression of wild type or mutant KIT in AML.

  5. The HIV-1 Tat protein modulates CD4 expression in human T cells through the induction of miR-222

    OpenAIRE

    Orecchini, Elisa; Doria, Margherita; Michienzi, Alessandro; Giuliani, Erica; Vassena, Lia; Ciafrè, Silvia Anna; Farace, Maria Giulia; Galardi, Silvia

    2014-01-01

    Several cellular microRNAs show substantial changes in expression during HIV-1 infection and their active role in the viral life cycle is progressively emerging. In the present study, we found that HIV-1 infection of Jurkat T cells significantly induces the expression of miR-222. We show that this induction depends on HIV-1 Tat protein, which is able to increase the transcriptional activity of NFkB on miR-222 promoter. Moreover, we demonstrate that miR-222 directly targets CD4, a key receptor...

  6. Functional balance between the hemagglutinin and neuraminidase of influenza A(H1N1pdm09 HA D222 variants.

    Directory of Open Access Journals (Sweden)

    Jean-Sébastien Casalegno

    Full Text Available D222G/N substitutions in A(H1N1pdm09 hemagglutinin may be associated with increased binding of viruses causing low respiratory tract infections and human pathogenesis. We assessed the impact of such substitutions on the balance between hemagglutinin binding and neuraminidase cleavage, viral growth and in vivo virulence.Seven viruses with differing polymorphisms at codon 222 (2 with D, 3 G, 1 N and 1 E were isolated from patients and characterized with regards hemagglutinin binding affinity (Kd to α-2,6 sialic acid (SAα-2,6 and SAα-2,3 and neuraminidase enzymatic properties (Km, Ki and Vmax. The hemagglutination assay was used to quantitatively assess the balance between hemagglutinin binding and neuraminidase cleavage. Viral growth properties were compared in vitro in MDCK-SIAT1 cells and in vivo in BALB/c mice. Compared with D222 variants, the binding affinity of G222 variants was greater for SAα-2,3 and lower for SAα-2,6, whereas that of both E222 and N222 variants was greater for both SAα-2,3 and SAα-2,6. Mean neuraminidase activity of D222 variants (16.0 nmol/h/10(6 was higher than that of G222 (1.7 nmol/h/10(6 viruses and E/N222 variants (4.4 nmol/h/10(6 viruses. The hemagglutination assay demonstrated a deviation from functional balance by E222 and N222 variants that displayed strong hemagglutinin binding but weak neuraminidase activity. This deviation impaired viral growth in MDCK-SIAT1 cells but not infectivity in mice. All strains but one exhibited low infectious dose in mice (MID50 and replicated to high titers in the lung; this D222 strain exhibited a ten-fold higher MID50 and replicated to low titers. Hemagglutinin-neuraminidase balance status had a greater impact on viral replication than hemagglutinin affinity strength, at least in vitro, thus emphasizing the importance of an optimal balance for influenza virus fitness. The mouse model is effective in assessing binding to SAα-2,3 but cannot differentiate SAα-2,3- from SA

  7. Laparoscopy in Management of Impalpable Testis in 222 Children%腹腔镜治疗不可触及型隐睾222

    Institute of Scientific and Technical Information of China (English)

    杨屹; 侯英; 陈辉; 王常林

    2012-01-01

    Objective To investigate and evaluate the application of laparoscopy in the diagnosis and treatment of the impalpable testis in children. Methods From Aug. 2005 to Jan. 2011, laparoscopy had been used in 222 patients with 229 impalpable testes. Patients' ages varied from 12 months to 16 years (median 56 months). The sites and sizes of the testes were identified by abdominopelvic ultraaonography (US) in all patients. The follow - up time ranged from 2 to 72 months ( mean 32 months). The follow - up included clinical examination and colored Doppler US in every patient who underwent orchiopexy. Results The diagnostic laparoscopy and histopathology were as follows: 158 testes were absent,11 testes were testicular nubbins,5 testes were inside the upper part of the inguinal canal,and the remaining 55 were in-traabnonninal (20 were low,35 were high). Four cases were complicated with degradation of yolk tube insufficiency,! case was true her-maphrnditism,l testis was streak gonad. Fifteen testes were managed by open orchiopexy; One - stage laparoscopic orchiopexy was performed on 15 testes, staged Fowler - Stephens ( F - S) orchiopexy on 25 testes , one - stage F - S orchiopexy for 8 testes, and laparoscopic orchidecto-my for 2 testes. Hysterectomy was performed for degradation of yolk tube insufficiency. Conadectomy was performed for the streak gonad. Histopathology proved an ovarian on one side and a testis on the other side in the case with true hermaphroditism. Doppler US was performed in every patient who underwent orchiopexy. After a mean follow - up period of 32 months,all but 6 testes were seen to be located in the bottom of the scrotum. Two tesles had retracted to the neck of the scrotum and 4 testes had atrophied, including 2 testes which received one - stage F - S orchiopexy, three testes received open orchiopexy and one testis received staged ¥ - S orchiopexy. Conclusions Laparoscopy has proven to be the only diagnostic modality whose findings provide a clear

  8. A direct evidence for high carbon dioxide and radon-222 discharge in Central Nepal

    International Nuclear Information System (INIS)

    Gas discharges have been identified at the Syabru-Bensi hot springs, located at the front of the High Himalaya in Central Nepal, in the Main Central Thrust zone. The hot spring waters are characterized by a temperature reaching 61 C, high salinity, high alkalinity and δ13C varying from +0. 7 parts per thousand to +4. 8 parts per thousand. The gas is mainly dry carbon dioxide, with a δ13C of -0. 8 parts per thousand. The diffuse carbon dioxide flux, mapped by the accumulation chamber method, reached a value of 19000 g m-2day-1, which is comparable with values measured on active volcanoes. Similar values have been observed over a two-year time interval and the integral around the main gas discharge amounts to 0. 25 ± 0. 07 mol s-1, or 350 ± 100 ton a-1. The mean radon-222 concentration in spring water did not exceed 2. 5 Bq L-1, exponentially decreasing with water temperature. In contrast, in gas bubbles collected in the water or in the dry gas discharges, the radon concentration varied from 16 000 to 41000 Bq m-3. In the soil, radon concentration varied from 25000 to more than 50000 Bq m-3. Radon flux, measured at more than fifty points, reached extreme values, larger than 2 Bq m-2s-1, correlated to the larger values of the carbon dioxide flux. Our direct observation confirms previous studies which indicated large degassing in the Himalaya. The proposed understanding is that carbon dioxide is released at mid-crustal depth by metamorphic reactions within the Indian basement, transported along pre-existing faults by meteoric hot water circulation, and degassed before reaching surface. This work, first, confirms that further studies should be undertaken to better constrain the carbon budget of the Himalaya, and, more generally, the contribution of mountain building to the global carbon balance. Furthermore, the evidenced gas discharges provide a unique natural laboratory for methodological studies, and appear particularly important to study as a function of time

  9. A direct evidence for high carbon dioxide and radon-222 discharge in Central Nepal

    Energy Technology Data Exchange (ETDEWEB)

    Perrier, F.; Byrdina, S. [Inst Phys Globe, UMR 7154, Equipe Geomagnetisme, F-75005 Paris (France); Univ Paris Diderot, F-75005 Paris (France); Richon, P.; Bollinger, L.; Bureau, S. [CEA Bruyeres le Chatel, DIF, Dept Anal Surveillance Environm, 91 (France); Richon, P. [Inst Phys Globe, UMR 7154, Equipe Geol Syst Volcan, F-75005 Paris (France); France-Lanord, Ch. [CNRS, Ctr Rech Petrog and Geochim, F-54501 Vandoeuvre Les Nancy (France); Rajaure, S.; Koirala, Bharat Prasad; Shrestha, Prithvi Lal; Gautam, Umesh Prasad; Tiwari, Dilli Ram; Sapkota, Soma Nath [Natl Seism Ctr, Dept Mines and Geol, Kathmandu (Nepal); Revil, A. [Colorado Sch Mines, Dept Geophys, Golden, CO 80401 (United States); Revil, A. [Univ Savoie, Equipe Volcans, CNRS, LGIT, UMR 5559, Chambery (France); Contraires, S. [Inst Phys Globe, Equipe Geomat and Environm, F-75005 Paris (France)

    2009-02-15

    Gas discharges have been identified at the Syabru-Bensi hot springs, located at the front of the High Himalaya in Central Nepal, in the Main Central Thrust zone. The hot spring waters are characterized by a temperature reaching 61 C, high salinity, high alkalinity and {delta}{sup 13}C varying from +0. 7 parts per thousand to +4. 8 parts per thousand. The gas is mainly dry carbon dioxide, with a {delta}{sup 13}C of -0. 8 parts per thousand. The diffuse carbon dioxide flux, mapped by the accumulation chamber method, reached a value of 19000 g m{sup -2}day{sup -1}, which is comparable with values measured on active volcanoes. Similar values have been observed over a two-year time interval and the integral around the main gas discharge amounts to 0. 25 {+-} 0. 07 mol s{sup -1}, or 350 {+-} 100 ton a{sup -1}. The mean radon-222 concentration in spring water did not exceed 2. 5 Bq L{sup -1}, exponentially decreasing with water temperature. In contrast, in gas bubbles collected in the water or in the dry gas discharges, the radon concentration varied from 16 000 to 41000 Bq m{sup -3}. In the soil, radon concentration varied from 25000 to more than 50000 Bq m{sup -3}. Radon flux, measured at more than fifty points, reached extreme values, larger than 2 Bq m{sup -2}s{sup -1}, correlated to the larger values of the carbon dioxide flux. Our direct observation confirms previous studies which indicated large degassing in the Himalaya. The proposed understanding is that carbon dioxide is released at mid-crustal depth by metamorphic reactions within the Indian basement, transported along pre-existing faults by meteoric hot water circulation, and degassed before reaching surface. This work, first, confirms that further studies should be undertaken to better constrain the carbon budget of the Himalaya, and, more generally, the contribution of mountain building to the global carbon balance. Furthermore, the evidenced gas discharges provide a unique natural laboratory for

  10. Volumic activities measurements and equivalent doses calculation of indoor 222Rn in Morocco

    Directory of Open Access Journals (Sweden)

    Abdelmajid Choukri

    2015-09-01

    Full Text Available Purpose: As a way of prevention, we have measured the volumic activities of indoor 222Rn and we have calculated the corresponding effective dose in some dwellings and enclosed areas in Morocco. Seasonal variation of Radon activities and Relationships between variation of these activities and some parameters such height, depth and type of construction were also established in this work.Methods: The passive time-integrated method of using a solid state nuclear track detector (LR-115 type II was employed. These films, cut in pieces of 3.4 ´ 2.5 cm2, were placed in detector holders and enclosed in heat-scaled polyethylene bags.Results: The measured volumic activities of radon vary in houses, between 31 and 136 Bq/m3 (0.55 and 2.39 mSv/year with an average value of 80 Bq/m3 (1.41 mSv/year. In enclosed work area, they vary between 60 Bq/m3 (0.38 mSv/year in an ordinary area to 1884 Bq/m3 (11.9 mSv/year at not airy underground level of 12 m. the relatively higher volumic activities of 222Rn in houses were measured in Youssoufia and khouribga towns situated in regions rich in phosphate deposits. Measurements at the geophysical observatory of Berchid show that the volumic activity of radon increases with depth, this is most probably due to decreased ventilation. Conclusion: The obtained results show that the effective dose calculated for indoor dwellings are comparable to those obtained in other regions in the word. The risks related to the volumic activities of indoor radon could be avoided by simple precautions such the continuous ventilation. The reached high value of above 1884 Bq/m3 don't present any risk for workers health in the geophysical observatory of Berchid because workers spend only a few minutes by day in the cellar to control and reregister data.

  11. Deposition of Chernobyl-derived transuranium nuclides and short- lived radon-222 progeny in Finland

    International Nuclear Information System (INIS)

    In this study the atmospheric deposition of radionuclides was investigated from two different viewpoints. The Chernobyl nuclear power plant accident in April 1986 caused a widely spread plume of radionuclides, including transuranium elements. The regional deposition of these elements in Finland was assessed based on lichen and peat samples. Unlike the deposition of transuranium elements from the weapons tests in the 1950's and 1960's, the deposition from the Chernobyl accident was very unevenly distributed in Finland. Also, the Chernobyl-derived deposition of 299,240Pu even in the most contaminated regions in Finland was still only some 10 per cent of the global fallout from weapons tests. On the other hand, the measured activity concentrations of 241Pu in the upper parts of lichen samples are comparable to those found in samples comparable during the heaviest weapons-test fallout in the early 1960's. The observed average 241Pu/239,240Pu activity ratio in the upper parts of lichen, 95, can be expected to lead at its maximum in the year 2059 to 241Am/239,240Pu activity ratio of 2.8 in the Chernobyl-derived deposition, exclusive of the 241Am present in the original deposition in 1986. The deposition pattern of transuranium elements observed in this work resembles that of refractory gamma-emitting nuclides such as 95Zr and 141Ce. The sampling area of this investigation does not cover the northern part of Finland. However, the fallout pattern of 95Zr would suggest that the deposition of transuranium nuclides north of the 65th latitude was very low. Biological half-lives of 730 d and 320 d for Pu and Am, respectively, were obtained in lichen in this study. The second part of this work is concerned with the factors affecting the wet deposition efficiency of the natural short-lived radon-222 progeny. This was studied with two methods: using recordings of external gamma radiation in central Finland, and using an automatic precipitation gamma analyser in northern Finland

  12. A contribution to the study of the behaviour of {sup 220}Rn, {sup 222}Rn and their daughters in the atmosphere; Contribution a l'etude du comportement du radon-220, du radon-222 et de leurs descendants dans l'atmosphere

    Energy Technology Data Exchange (ETDEWEB)

    Kataoka, T.; Yunoki, E.; Michihiro, K.; Sugiyama, H.; Shimizu, M.; Mori, T. [Okayama Prefectural Institute for Environmental Science and Public Health, Uchio, Okayama (Japan); Tsukamoto, O.; Sahashi, K. [Okayama Univ. (Japan). Faculty of Science; Maitani, T. [Okayama Univ. (Japan). Inst. for Bioresources

    1999-06-01

    We simultaneously measured the concentrations of {sup 212}Pb (a {sup 220}Rn daughter) and short-lived {sup 222}Rn daughters, and some meteorological elements at three sites 2-3 km apart in Kamisaibara Village (Okayama Prefecture, Japan). The resulting data shows that variations of the concentrations of {sup 212}Pb and {sup 222}Rn daughters and of the ratio Pb/Rn-daughters at these three sites are correlated, but that their levels are considerably influenced by emanations of {sup 220}Rn and {sup 222}Rn from the soil near the observation sites. The results of further treatment make it clear that the addition of Pb/Rn (the ratio of the concentrations of {sup 212}Pb and {sup 222}Rn) or of Pb/Rn-daughters as an indicator to one of the concentrations of {sup 212}Pb, {sup 222}Rn and {sup 222}Rn daughters enables us to get information about the state of the lower atmosphere. Considering the above, the ratio Pb/Rn or Pb/Rn-daughters will be useful as a tracer for elucidation of the behaviour of air pollutants in urban and industrial areas, as well as the concentrations of {sup 212}Pb, {sup 222}Rn and {sup 222}Rn daughters. (author)

  13. Study of Rn-222 exhalation in phosphogypsum through the adsorption technique in activated coal; Estudo da exalacao de Rn-222 em fosfogesso por meio da tecnica de adsorcao em carvao ativado

    Energy Technology Data Exchange (ETDEWEB)

    Nisti, Marcelo Bessa; Campos, Marcia Pires de, E-mail: mbnisti@ipen.b, E-mail: mpcampos@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-10-26

    The radon exhalation was estimated through the adsorption in activated carbon technique. Classified as TENORM, the radon exhalation determination on the phosphogypsum piles was performed through the adsorption ratio of radon in activated carbon, from the concentration of descendants of {sup 222}Rn, {sup 214}Pb and {sup 214}Bi obtained by gamma spectrometry. The results obtained in this work were compatibles with the values found in the literature

  14. The 222 Rn Volume Radioactivity Response of AlphaGUARD Radon Monitor in Active/passive Mode%AlphaGUARD 在主/被动模式下对222 Rn体积活度的响应

    Institute of Scientific and Technical Information of China (English)

    陆小军; 何林锋; 徐一鹤; 曹振; 孙训; 唐方东

    2014-01-01

    AlphaGUARD radon monitor is the most stable and accurate radon detector at present , widely used as radon measurement standard delivery device at home and abroad .This paper introduced the AlphaGUARD ra-don volume activity response from low to high volume of radio -activity based on the actual applications , and made a comparative analysis of AlphaGUARD measuring radon activity in two modes .the results showed that:Firstly, the volume activity response of AlphaGUARD at active mode is smaller than the response at passive mode ;secondly , AlphaGUARD volume activity response doesn't changes with flow rate of sampling pump obvi-ously;thirdly, the222 Rn measurement repeatability decreases with the increase of 222 Rn volume activity, but not varied with the sampling flow rate .%AlphaGUARD是目前技术性能最优的测氡仪之一,常用作氡测量传递标准。文章介绍了AlphaGUARD主动与被动测量模式的原理,对AlphaGUARD在主动和被动两种工作模式下和不同采样流速下的氡体积活度响应作了分析对比,实验结果表明:主动模式下AlphaGUARD体积活度响应小于在被动模式下,采样流速对AlphaGUARD的体积活度响应无明显影响;AlphaGUARD对222 Rn体积活度的测量重复性随222 Rn体积活度的增大而减小,但是尚得不到其重复性随采样流量的变化规律。

  15. Calibration of a degassing-emanation line for 222Rn determination in seawater samples; Calibracao de uma linha de emanacao para determinacao de {sup 222}Rn em amostras de agua do mar

    Energy Technology Data Exchange (ETDEWEB)

    Farias, Luciana Aparecida

    2002-07-01

    The purpose of this study is to calibrate a degassing-emanation line and to determine {sup 222}Rn and {sup 226}Ra activity concentrations in seawater samples. This methodology, also called Lucas method, consists in the extraction of radon (originally dissolved in seawater), collection of the gas in a liquid nitrogen cold trap and transfer from the trap to an alpha scintillation cell. Total extraction efficiencies of the 4 degassing-emanation systems were determined by measuring {sup 226}Ra reference solutions. The efficiencies obtained for these 4 systems varied from 21 % to 62%. This work also presents preliminary results of a study carried out in a series of small embayements of Ubatuba, Sao Paulo State-Brazil: Flamengo Bay, Fortaleza Bay, Mar Virado Bay and Ubatuba Bay. Concentration of Rn in excess varied from 0,011 to 0,317 Bq/L for Flamengo Bay, from 0,009 to 0,130 Bq/L for Fortaleza Bay, from 0,018 to 0,050 Bq/L for Mar Virado Bay and from 0,004 to 0,120 Bq/L for Ubatuba Bay. The results obtained for the concentration of {sup 222}Rn in excess in a transect at Flamengo Bay varied from 0,002 to 0,036 Bq/L. Higher concentrations of {sup 222}Rn in excess were obtained in Flamengo Bay, Fortaleza Bay and Ubatuba bay. It was also observed that the concentration of {sup 222}Rn in excess increases with depth, as expected. (author)

  16. Dosimetry of Rn-222 in the air in environments located above and below ground level; Dosimetria de Rn-222 no ar em ambientes localizados acima e abaixo do nivel do solo

    Energy Technology Data Exchange (ETDEWEB)

    Cazula, Camila Dias

    2015-07-01

    Exposure of the general population to ionizing radiation comes mainly from natural sources. The main contribution is due to inhalation of radon (Rn-222), a gas that occurs naturally (UNSCEAR, 2000). The Rn-222 concentration in the environment is controlled by factors such as soil permeability and water content, the weather variability, materials used in the foundation and the usual positive pressure differential between the soil and the internal environment. Studies indicate that the concentration of radon shows a wide variation in the basement, ground floor and upper floors of buildings. The objective of this study is to determine radon levels in basements, ground floor and floors above ground level, at a university in the city of Sao Paulo and in one residential building in the city of Peruibe. Rn-222 measurements were performed using the method with nuclear track of solid state detectors (CR-39). The studied environments present Rn-222 concentration well below the values recommended by the International Commission on Radiological Protection, published in the 2009 document, of 300 Bq/m{sup 3} for homes and 1000 Bq/m{sup 3} for the workplace. In the residential building, the concentration of Ra-266, Th-232 and K-40 in the materials used in the building construction was also analyzed, by gamma spectrometry. The effective total dose for the resident due to external exposure was 0.8 mSv y{sup -1}, lower than the annual dose limit for the general public of 1 mSv y{sup -1}. (author)

  17. Atmospheric chemistry observation at the summit of Mt. Fuji using 7Be and 222Rn as atmospheric tracers

    International Nuclear Information System (INIS)

    Observations on atmospheric naturally occurring radionuclides, which have definite sources could provide useful information on emission, transport and removal processes, etc for other important atmospheric chemical species. For the purpose, 7Be and 222Ru seem most useful to know about the free tropospheric processes. We have observed 7Be and 222Ru at the summit of Mt. Fuji (3,776 m a.s.l.) along with O3, SO2, CO. Those data were analyzed to suggest the possible transport of O3 from the upper atmosphere and of polluted air mass from the boundary layer over the Asian continent to the lower free troposphere over Japan. The present work shows the possible application of the atmospheric radionuclides data to understanding the atmospheric physical and chemical processes. (author)

  18. Experimental test on the use of MS-222 for ostracod anaesthesia: concentration, immersion period and recovery time

    Directory of Open Access Journals (Sweden)

    Francesc MEZQUITA

    2010-08-01

    Full Text Available Anaesthesia of animals may be useful for different purposes, particularly for veterinary reasons or in experimental research, for manipulation or treatment of immobilized but alive animals. Its use in crustaceans is not uncommon, but it has never been described for Ostracoda. We provide brief and preliminary guidelines on the use of the tricaine mesylate (MS-222 on the widespread freshwater ostracod Eucypris virens and we show that this compound is an effective anaesthetic used as a bath treatment at minimum concentrations of 500 mg L-1. This value is considerably higher than that recommended for other aquatic animals like fish. Recovery time, ranging from 5 to 15 minutes, is mostly determined by anaesthetic bath concentration, while bath duration influenced to a lesser extent. Anaesthesia induced with MS-222 can prove useful for minute manipulation of living ostracods e.g. for identification, marking or image capture under the microscope.

  19. Precursory Subsurface 222Rn and 220Rn Degassing Signatures of the 2004 Seismic Crisis at Tenerife, Canary Islands

    Science.gov (United States)

    Pérez, Nemesio M.; Hernández, Pedro A.; Padrón, Eleazar; Melián, Gladys; Marrero, Rayco; Padilla, Germán; Barrancos, José; Nolasco, Dácil

    2007-12-01

    Precursory geochemical signatures of radon degassing in the subsurface of the Tenerife Island were observed several months prior to the recent 2004 seismic-volcanic crisis. These premonitory signatures were detected by means of a continuous monitoring of 222Rn and 220Rn activity from a bubbling CO2-rich gas spot located at 2.850 m depth inside a horizontal gallery for groundwater exploitation at Tenerife. Multivariate Regression Analysis (MRA) on time series of the radon activity was applied to eliminate the radon activity fluctuation due to external variables such as barometric pressure, temperature and relative humidity as well as power supply. Material Failure Forecast Method (FFM) was successfully applied to forecast the anomalous seismicity registered in Tenerife Island in 2004. The changes in the 222Rn/220Rn ratio observed after the period of anomalous seismicity might suggest a higher gas flow rate and/or changes in the vertical permeability induced by seismic activity.

  20. Evaluation of 222radon occupational exposure in underground workplaces: tunnels used for mushroom cultivation in Italy

    International Nuclear Information System (INIS)

    The mushroom cultivation in tunnels represents a working activity with interesting characteristics from a radiological protection point of view. The practice of using tunnels or caves for the cultivation of mushrooms is diffused in many countries as well as in several Italian regions. These places are characterized by micro climate conditions (temperature, humidity, etc.) particularly adapted for the growth of mushrooms in every period of the year. This practice, like every working activity carried out in underground workplaces, is regulated by the Italian implementation of the European Union Basic Safety Standards (E.U. B.S.S., 1996). With the aim to evaluate the 222Rn exposure of workers in tunnels used for mushroom cultivation, a study has been undertaken. In particular, hygienic and micro climatic characteristics (depth, temperature, relative humidity, barometric pressure, ventilation, etc.) and radiometric parameters (indoor radon concentration, radon decay products concentration, equilibrium factor F) have been investigated. In the present paper, the results of the two steps of the study are reported. In the first step, an operative protocol has been defined: the protocol was put through a series of measurements in two tuff tunnels in the area of Rome. In the second step, several tunnels used for mushroom cultivation, located in different Italian regions, have been monitored and experimental data have been used to estimate annual effective doses of workers due to radon inhalation.The experimental results have been analyzed in the context of the E.U. B.S.S

  1. Design and performance characteristics of a krypton chloride ( = 222 nm) excimer laser

    Indian Academy of Sciences (India)

    N S Benerji; N Varshnay; A Singh; Bijendra Singh

    2014-01-01

    Development of a discharge-pumped krypton chloride (KrCl) laser operating at 222 nm wavelength is demonstrated. In this paper the design, successful realization and operating characteristics of KrCl excimer laser are reported. The laser is driven by a simple and efficient excitation technique using automatic UV pre-ionization with discharge-pumped self-sustained capacitor– capacitor (C–C) energy transfer circuit. The experimental investigations including output laser energy, temporal pulse parameters, emission spectra and beam profile of the KrCl laser were recorded. For high repetition rate operation, in-built, compact gas circulation system using tangential blower was incorporated. The laser was operated at 25 kV discharge voltage, gas mixture of 5 mbar HCl, 160 mbar kypton and neon as balance with a total gas pressure of ∼2.5 bar. These experiments produced an efficient and reliable output energy of 25 mJ from an active volume of 60 cm3.

  2. Using (222)Rn as a tracer of geodynamical processes in underground environments.

    Science.gov (United States)

    Valladares, D L; da Silva, A A R; Lacerda, T; Anjos, R M; Rizzotto, M; Velasco, H; de Rosas, J P; Tognelli, G; Yoshimura, E M; Ayub, J Juri

    2014-01-15

    Radon levels in two old mines in San Luis, Argentina, were measured and analyzed, with the aim to assess the potential use of this radioactive noble gas as a tracer of geological processes in underground environments. La Carolina gold mine and Los Cóndores tungsten mine are today used as tourism mines. CR-39 nuclear track detectors were used for this purpose. Measurements were performed during both winter and summer seasons. The findings show that in these environments, significant radon concentrations are subject to large seasonal fluctuations, due to the strong dependence on natural ventilation with the outside temperature variations. For both mines, higher concentration values of (222)Rn were observed in summer than in winter; with an extreme ratio of 2.5 times between summer and winter seasons for Los Cóndores mine. The pattern of radon transport inside La Carolina mine revealed, contrary to what was believed, that this mine behaves as a system with two entrances located at different levels. However, this feature can only be observed in the winter season, when there is a marked difference between the inside and outside temperatures of the mine. In the case of Los Cóndores mine, the radon concentration pattern distribution is principally established by air current due to chimney-effect in summer and winter seasons. In both cases, the analyses of radon pattern distribution appear as a good method to trace air currents, and then localize unknown ducts, fissures or secondary tunnels in subterranean environments. PMID:24012891

  3. Genetic effects of radon 222 in a population of Drosophila melanogaster chronically exposed

    International Nuclear Information System (INIS)

    It was investigated the mutagenic effect of Radon 222 during a experimental period of 11 generations. In this lapse Drosophila melanogaster larvae line Canton-S were maintained in a radon atmosphere. In each test generation had been extracted males, consequently exposed to radiation which were subjected to a crossing series with a bearer marker genes of according to the Wallace experimental design (1956). Due to the experimental conditions it only was determined the recessive lethal mutations frequency for the second chromosome in the 1,4,7 and 11 generations. Of all study it was conduced in parallel way a non-treated witness population. The concentrations at which was subjected the experimental population varied of generation to generation from 12 ± 2 to 43 ± 5 kBq/m3. Our analysis correspond to lethality determination in 1182 second chromosomes distributed between two populations and the different exposition generations. The study allow to determine the respective frequencies of recessive lethal genes varying according to the population and/or generation between 10.53 and 22.02%. The statistical analysis of data did not show significant differences among the different populations. (Author)

  4. Velocity and particle mixing in a new stack at the 222-S Analytical Lab

    International Nuclear Information System (INIS)

    Air velocities in the newly planned exhaust system at building 222-S are calculated for several operating scenarios. The exhaust system consists of 4 rectangular ducts, a 66-in diameter stack about 9 meters tall, and a transition volume between the ducts and the stack. Air flowing through the exhaust system is filtered by multiple stages of HEPA filters. However, if there were a failure of each and every stage of filters, which is very unlikely and not part of this analysis, some particles may get into the stack. Air from the stack is sampled periodically for particles to determine the level of particle concentrations in the stack. Since the particles may come from just one inlet duct, the horizontal distribution of the particles in the stack may not be uniform. The particle concentration profiles at various locations in the stack and transition volume are calculated using a CFD (Computational Fluid Dynamics) code. Particle concentrations are calculated for solid respirable particles with a unit density and a diameter of 5 microns

  5. Photo-fenton process: Optimization and decolourization and mineralization of reactive blue 222 dye

    Directory of Open Access Journals (Sweden)

    Shumaila Kiran

    2012-12-01

    Full Text Available Dye house effluents of textile industries leads to severe environmental problems when disposed to aquatic bodies without proper treatment. This work was carried out to optimize the Photo-Fenton process for decolorization and mineralization of a commercial textile dye, Reactive Blue 222. The effect of different process parameters on decolorization efficiency of Photo-Fenton process was investigated. The optimal conditions for process were observed as; pH level 3.5, H2O2 concentration 1× 10-2M, FeSO4 concentration 3.5 × 10-5 mol L-1, temperature 50˚C and process time 50 min. The maximum 95% dye decolorization was achieved along with a significant (P< 0.05 reduction of chemical oxygen demand and total organic. The degradation products were characterized by UV–visible and FTIR spectral techniques. The results provide evidence that Photo-Fenton process was able to oxidize and mineralize the selected azo dye into non-toxic metabolites.

  6. A long-period Cepheid variable in the starburst cluster VdBH222

    CERN Document Server

    Clark, J S; Lohr, M E; Dorda, R; González-Fernández, C; Lewis, F; Roche, P

    2015-01-01

    Galactic starburst clusters play a twin role in astrophysics, serving as laboratories for the study of stellar physics and also delineating the structure and recent star formation history of the Milky Way. In order to exploit these opportunities we have undertaken a multi-epoch spectroscopic survey of the red supergiant dominated young massive clusters thought to be present at both near and far ends of the Galactic Bar. Significant spectroscopic variability suggestive of radial pulsations was found for the yellow supergiant VdBH 222 #505. Follow-up photometric investigations revealed modulation with a period of ~23.325d; both timescale and pulsational profile are consistent with a Cepheid classification. As a consequence #505 may be recognised as one of the longest period Galactic cluster Cepheids identified to date and hence of considerable use in constraining the bright end of the period/luminosity relation at solar metallicities. In conjunction with extant photometry we infer a distance of ~6kpc for VdBH22...

  7. Removal of long-lived {sup 222}Rn daughters by electropolishing thin layers of stainless steel

    Energy Technology Data Exchange (ETDEWEB)

    Schnee, R. W.; Bowles, M. A.; Bunker, R.; McCabe, K.; White, J. [Department of Physics, Syracuse University, Syracuse, NY 13244 (United States); Cushman, P.; Pepin, M. [School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455 (United States); Guiseppe, V. E. [University of South Dakota, Vermillion, South Dakota 57069 (United States)

    2013-08-08

    Long-lived alpha and beta emitters in the {sup 222}Rn decay chain on detector surfaces may be the limiting background in many experiments attempting to detect dark matter or neutrinoless double beta decay. Removal of tens of microns of material via electropolishing has been shown to be effective at removing radon daughters implanted into material surfaces. Some applications, however, require the removal of uniform and significantly smaller thicknesses. Here, we demonstrate that electropolishing < 1 μm from stainless-steel plates reduces the contamination efficiently, by a factor > 100. Examination of electropolished wires with a scanning electron microscope confirms that the thickness removed is reproducible and reasonably uniform. Together, these tests demonstrate the effectiveness of removal of radon daughters for a proposed low-radiation, multi-wire proportional chamber (the BetaCage), without compromising the screener’s energy resolution. More generally, electropolishing thin layers of stainless steel may effectively remove radon daughters without compromising precision-machined parts.

  8. Estimating the relation between groundwater and river water by measuring the concentration of Rn-222

    Energy Technology Data Exchange (ETDEWEB)

    Yoneda, Minoru; Morisawa, Shinsuke [Kyoto Univ. (Japan). Faculty of Engineering

    1997-02-01

    This study aimed to estimate the relationship between groundwater in shallow layer and river water by determining the concentrations of {sup 222}Rn and nitric nitrogen along with water temperature. The region around ca. 20 km along river A in a certain basin was chosen as a test area. The Rn concentration of groundwater was determined by Rn extracting with toluene and counting in liquid scintillation counter, whereas for river water, it was determined by activated charcoal passive collector method developed by the authors, by which the amount of Rn adsorbed on activated charcoal was estimated by Ge-solid state detector. In addition, water temperature and nitric nitrogen concentration were measured at various points in the test area. Thus, a distribution map of the three parameters was made on the basis of the data obtained in December, 1989. Since Rn concentration is generally higher in ground water than river water and the water temperature in December is higher in the former, it seems likely that the concentrations of Rn and nitric nitrogen would become higher in the area where ground water soaks into river water. Thus, the directions of ground water flow at the respective sites along river A were estimated from the data regarding the properties of ground water. (M.N.)

  9. Rn-222 concentrations in private well water and in river water around Ningyo Toge area

    Energy Technology Data Exchange (ETDEWEB)

    Yunoki, Eiji [Okayama, Prefectural Inst. for Environmental Science and Public Health (Japan)

    1997-02-01

    The Ningyo-Toge Works of Power Reactor and Nuclear Fuel Development Corporation have started the pilot plant for uranium refining and conversion in 1984 and thereafter been producing 6-uranium fluoride, which is a raw material for an uranium concentration plant. The operation of prototype reactor has started since 1989. In this study, radioactive contamination around the works under these circumstances has been monitored in the respects of Rn concentrations in well water and river one for more than 10 years. The radioactivities of well water sampled at 4 points in this area were in a range of 0.6-82.9 Bq/l. The differences in the activities seemed to be depending on petrological properties. For the river water, the Rn concentration was determined at 13 points in the area. Seasonal changes in the Rn concentrations were not significant (p<0.05) but there were significant changes among years during 1985-1995. Further, the radioactive levels of soils collected from riverbed at 5 points were significantly different both for {sup 238}U and {sup 226}Ra, but the ratios of {sup 238}U/{sup 226}Ra were consistent. Furthermore, there was no correlation between {sup 226}Ra and {sup 222}Rn concentrations in the river water. (M.N.)

  10. Variation of radon-222 concentration in exposure systems air under different conditions of exposure

    Science.gov (United States)

    Mamoon, A.; Abdul-Fattah, A. A.; Qari, T. M.

    1994-07-01

    Simplified, laboratory scale systems, namely ordinary laboratory desiccators and cylindrical containers were tested with regard to their reliability as exposure systems for determining certain parameters of radon emanation from locally obtained crushed granite rock samples. The samples were placed inside the exposure systems. Activity concentration of emanated radon in the exposure systems air increased with increase of mass of granite sample in the desiccator and with length of the exposure period. Activity concentration of radon was high near the granitic source but decreased with vertical distance from it when the exposure system was semiclosed but activity was homogeneous when the system was completely closed. The cylindrical exposure system was used in assessing Ra-226 content in some crushed granitic samples identified as altered alkali granite and found to be: 0.024 Bq g-1 (0.65 pCig-1). Rn-222 emanation rate from the same samples was: 0.013 Bq m-2 s-1 (0.34 pCi m-2 s-1). Saturation density thickness for a mixed sample of pure and alkali granites was found to be 116 g cm-2. The results agree in general with reported observations and support the reliability of the exposure systems used.

  11. Indoor concentrations of radon 222 and its daughters: sources, range, and environmental influences

    International Nuclear Information System (INIS)

    The author here reviews what is presently known about factors affecting indoor concentrations of radon 222 and its daughters. In US single-family homes, radon concentrations are found to average about 1.5 pCi/1, but substantially higher concentrations occur frequently: perhaps a million US homes have concentrations exceeding 8 pCi/1 (from which occupants receive radiation doses comparable to those now experienced by uranium miners). The major contributor to indoor radon is ordinary soil underlying homes, with this radon being transported indoors primarily by the slight depressurization that occurs toward the bottom of a house interior (due to indoor-outdoor temperature differences and winds). Water from underground sources contributes significantly in a minority of cases, primarily residences with private wells, with public water supplies contributing only a few percent of indoor radon, even when drawn from wells. The strong variability in indoor concentrations is associated primarily with variability in the amount of radon entering homes from these various sources, and secondarily with differences in ventilation rates. However, for a given entry rate, the ventilation rate is the key determinant of indoor concentrations. Human doses are also influenced strongly by the chemical behavior of the daughters (i.e., decay products of radon), and considerable progress has been made recently in investigating a major aspect of this behavior, i.e., the manner in which daughters attach to airborne particles, to walls, and - indeed - to the lining of the lung itself, where the key radiation dose occurs

  12. Assessment and prevention of radioactive risk due to 222Radon on University Premises in Genoa, Italy.

    Science.gov (United States)

    Panatto, D; Gasparini, R; Benatti, U; Gallelli, G

    2006-12-01

    From October 2004 to September 2005, Radon222 activity in high-risk indoor spaces used by employees and students at the University of Genoa was measured with CR-39 nuclear track detectors. The mean concentration in winter (78.9 Bq/m3 +/- 74.92 S.D.) was low in relation to the microenvironment considered. When data were broken down by type and location of the spaces, no significant differences were found, despite the fact that the Genoa conurbation lies on soil of variable geological composition. The dose absorbed by employees was 0.42 mSv/year, with a relative risk of 4.2/1000 cases of Radon-related lung cancer. The dose absorbed by students was 0.28 mSv/year, with a relative risk of 2.5/1000 cases of Radon-related lung cancer. The level of radon activity detected never exceeded the limit of 500 Bq/m3 established by Italian law. Nevertheless, the value of the compound uncertainty index suggested that the real level of Radon contamination could have exceeded 400 Bq/m3 in selected spaces, a value requiring annual concentration tests.

  13. Using (222)Rn as a tracer of geodynamical processes in underground environments.

    Science.gov (United States)

    Valladares, D L; da Silva, A A R; Lacerda, T; Anjos, R M; Rizzotto, M; Velasco, H; de Rosas, J P; Tognelli, G; Yoshimura, E M; Ayub, J Juri

    2014-01-15

    Radon levels in two old mines in San Luis, Argentina, were measured and analyzed, with the aim to assess the potential use of this radioactive noble gas as a tracer of geological processes in underground environments. La Carolina gold mine and Los Cóndores tungsten mine are today used as tourism mines. CR-39 nuclear track detectors were used for this purpose. Measurements were performed during both winter and summer seasons. The findings show that in these environments, significant radon concentrations are subject to large seasonal fluctuations, due to the strong dependence on natural ventilation with the outside temperature variations. For both mines, higher concentration values of (222)Rn were observed in summer than in winter; with an extreme ratio of 2.5 times between summer and winter seasons for Los Cóndores mine. The pattern of radon transport inside La Carolina mine revealed, contrary to what was believed, that this mine behaves as a system with two entrances located at different levels. However, this feature can only be observed in the winter season, when there is a marked difference between the inside and outside temperatures of the mine. In the case of Los Cóndores mine, the radon concentration pattern distribution is principally established by air current due to chimney-effect in summer and winter seasons. In both cases, the analyses of radon pattern distribution appear as a good method to trace air currents, and then localize unknown ducts, fissures or secondary tunnels in subterranean environments.

  14. Discovery of a deep Seyfert-2 galaxy at z = 0.222 behind NGC 300

    CERN Document Server

    Combi, J A; Rodriguez, M J; Gamen, R; Cellone, S A

    2016-01-01

    We report on the unveiling of the nature of the unidentified X-ray source 3XMM J005450.3-373849 as a Seyfert-2 galaxy located behind the spiral galaxy NGC 300 using Hubble Space Telescope data, new spectroscopic Gemini observations and available XMM-Newton and Chandra data. We show that the X-ray source is positionally coincident with an extended optical source, composed by a marginally resolved nucleus/bulge, surrounded by an elliptical disc-like feature and two symmetrical outer rings. The optical spectrum is typical of a Seyfert-2 galaxy redshifted to z=0.222 +/- 0.001, which confirms that the source is not physically related to NGC 300. At this redshift the source would be located at 909+/-4 Mpc (comoving distance in the standard model). The X-ray spectra of the source are well-fitted by an absorbed power-law model. By tying $N_\\mathrm{H}$ between the six available spectra, we found a variable index $\\Gamma$ running from ~2 in 2000-2001 years, to 1.4-1.6 in the 2005-2014 period. Alternatively, by tying $\\...

  15. Surface-deposition and Distribution of the Radon (222Rn and 220Rn) Decay Products Indoors

    Science.gov (United States)

    Espinosa, G.; Tommasino, Luigi

    The exposure to radon (222Rn and 220Rn) decay products is of great concern both in dwellings and workplaces. The model to estimate the lung dose refers to the deposition mechanisms and particle sizes. Unfortunately, most of the dose data available are based on the measurement of radon concentration and the concentration of radon decay products. These combined measurements are widely used in spite of the fact that accurate dose assessments require information on the particle deposition mechanisms and the spatial distribution of radon decay products indoors. Most of the airborne particles and/or radon decay products are deposited onto indoor surfaces, which deposition makes the radon decay products unavailable for inhalation. These deposition processes, if properly known, could be successfully exploited to reduce the exposure to radon decay products. In spite of the importance of the surface deposition of the radon decay products, both for the correct evaluation of the dose and for reducing the exposure, little or no efforts have been made to investigate these deposition processes. Recently, two parallel investigations have been carried out in Rome and at Universidad Nacional Autónoma de México (UNAM) in Mexico City respectively, which address the issue of the surface-deposited radon decay products. Even though these investigations have been carried independently, they complement one another. It is with these considerations in mind that it was decided to report both investigations in the same paper.

  16. Investigation of some factors affecting on release of radon-222 from phosphogypsum waste associated with phosphate ore processing.

    Science.gov (United States)

    Hilal, M A; El Afifi, E M; Nayl, A A

    2015-07-01

    The aim of this study is oriented to investigate the influence of some physicochemical factors such as radium distribution, grain size, moisture content and chemical constituents on releases of radon-222 from the accumulated phosphogypsum (PG) waste. The emanation fraction, activity concentration in the pore and the surface exhalation rate of radon-222 in the bulk PG waste are 34.5 ± 0.3%, 238.6 ± 7.8 kBq m(-3) and 213 ± 6.9 mBq m(-2) s(-1), respectively. These values were varied and enhanced slightly in the fine grain sizes (F1 Ra-226), calcium (CaSO4) and strontium (SrO). About 67% of radon release attributed to the grain size below 0.5 mm, while 33% due to the large grain size above 0.5 mm. The emanation fraction of Rn-222 is increased with moisture content and the maximum emanation is ∼43% of moisture of 3-8%. It reduced slowly with the continuous increase in moisture till 20%. Due to PG waste in situ can be enhancing the background to the surround workers and/or public. Therefore, the environmental negative impacts due to release of Rn-222 can be minimized by legislation to restrict its civil uses, or increasing its moisture to ∼10%, or by the particle size separation of the fine fraction containing the high levels of Ra-226 followed by a suitable chemical treatment or disposal; whereas the low release amount can be diluted and used in cement industry, roads or dam construction.

  17. LiOOt-Bu as a terminal oxidant in a titanium alkoxide-mediated [2+2+2] reaction cascade☆

    Science.gov (United States)

    Kim, Wan Shin; Aquino, Claudio; Mizoguchi, Haruki; Micalizio, Glenn C.

    2015-01-01

    LiOOt-Bu is an effective oxidant for converting the penultimate organometallic intermediate generated in a titanium alkoxide-mediated [2+2+2] reaction cascade to an allylic alcohol. Oxidation of the presumed allylic titanium species is highly regioselective, providing direct access to substituted hydroindanes containing a primary allylic alcohol. In addition to demonstrating the feasibility of this oxidation process, we document the ability to convert the primary allylic alcohol products to angularly substituted cis-fused hydroindanes. PMID:26097265

  18. Seasonal variation of 226Ra and 222Rn in mineral spring waters of Aguas da Prata-Brazil

    International Nuclear Information System (INIS)

    Concentration levels of 226Ra and 222Rn have been analysed in most of the mineral spring waters available in the Aguas da Prata region, which is located in the Pocos de Caldas plateau, one of the biggest weathered alkaline intrusions of the world. In this plateau can be found many health resorts[based on springs of thermal and mineral waters. The Aguas da Prata spring waters show a large variety of composition. It has been observed bicarbonates, carbonates and sulphates salts in these mineral waters. The 226Ra was determined by gross alpha counting of a Ba(Ra)SO4 precipitate. The measurement was carried out in a low background gas flow proportional counter. The 222Rn concentrations were determined by liquid scintillation method. Water samples were randomly collected at 9 spring sites over a period of one year, in order to evaluate the seasonal variation of these radionuclides. Lower concentrations were found mostly in the rainy season (summer), which presents 80% of the annual rainfall of the region (1500 mm/year). Higher concentrations up to 2223 mBq/L for 226Ra and 131 Bq/L for 222Rn have been observed in waters with low level of soluble salts. Waters which present high levels of carbonate and sulphate salts showed maximum values of 316 mBq/L for 226Ra and 30 Bq/L for 222Rn. This behaviour is mainly due to the physicochemical properties of these radionuclides in water as well as to the lithologic structure of the aquifers. (authors). 6 refs., 2 figs., 1 tab

  19. Quantifying groundwater discharge to Cockburn River, southeastern Australia, using dissolved gas tracers 222Rn and SF6

    OpenAIRE

    Cook, PG; Lamontagne, S; Berhane, D; Clark, JF

    2006-01-01

    Groundwater discharge to the Cockburn River, southeast Australia, has been estimated from comparison of natural 222Rn activities in groundwater and river water, interpreted using a numerical flow model that simulates longitudinal radon activities as a function of groundwater inflow, hyporheic exchange, evaporation, gas exchange with the atmosphere, and radioactive decay. An injection of SF6 into the river to estimate the gas transfer velocity assisted in constraining the model. Previous estim...

  20. Asymmetric 1,4-bis(ethynylbicyclo[2.2.2]octane rotators via monocarbinol functionalization. Ready access to polyrotors

    Directory of Open Access Journals (Sweden)

    Cyprien Lemouchi

    2015-10-01

    Full Text Available Asymmetric rotators with a 1,4-bis(ethynylbicyclo[2.2.2]octane (BCO core are needed for engineering crystalline arrays of functional molecular rotors. Their synthesis uses carbinol, 2-methyl-3-butyn-2-ol, as a protecting group because of its polar character and its ability to sustain orthogonal functionalization with the further advantage of being readily removed. The synthesis in good yields of unprecedented asymmetric rotors and polyrotors demonstrates the efficiency of this strategy.

  1. Measurements of {sup 222}Rn and{sup 220}Rn with a large size collector of radon progeny

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Qifan; Cheng, Jianping; Liu, Guilin; Zhu, Li [Tsinghua Univ., Beijing (China); Ja, Wenyi; Fang, Fang [Chengdu Univ. of Technology, Chengdu (China)

    2002-07-01

    People have paid more attention to radon since 1980s. Radon concentrations in high background radiation areas in the south are higher than others in China, especially {sup 220} Rn concentration is significantly high. Therefore, measurement of {sup 222} Rn and {sup 220} Rn concentration should be carried out there. I will introduce a large size collector of radon progeny and its applications in this paper. The collector is a sheet of polyvinyl chloride fibre with electrostatics of -500V {approx} -700V. Its size (60mm in diameter) is larger than others (26mm in diameter) that work as the same principle. The collector is more effective to adsorb radon progeny than most of others. The equipment of ZnS(Ag) Scintillation Counting System is available for large size collectors to detect radon progeny. Therefore its sensitivity of measurement is high than others. According to the different half life of radon progeny and based on both theory and experiment, a formula for discrimination and calculation of {sup 222} Rn and {sup 220} Rn concentrations was deduced. The {sup 222} Rn and {sup 220} Rn concentrations were surveyed with electrostatic collectors of radon progeny on the campus of commercial school and some other areas in Hainan, southern China. Neither {sup 222} Rn nor {sup 220} Rn concentrations were found significant high. However several faults underground were delineated. The collector is also used to study radon transportation. Results indicate that radon changes regularly with date when it has transported for a certain distance. Velocities of radon migration in the four media are quite different. Radon migrates more quickly in vertical tube than in the horizontal tube.

  2. Controls on the spatial and temporal variability of Rn-222 in riparian groundwater in a lowland Chalk catchment.

    OpenAIRE

    Mullinger, Neil J.; Pates, Jackie M.; Binley, Andrew M.; Crook, N. P.

    2009-01-01

    Radon is a powerful tracer of stream-aquifer interactions. However, it is important to consider the source and behaviour of radon in groundwater when interpreting observations of river radon in relation to groundwater discharge. Here we characterise the variability in groundwater radon concentrations in the riparian zone of a Chalk catchment. Groundwater 222Rn (radon) concentrations were determined in riparian zone boreholes at two sites in the Lambourn catchment, Berkshire, UK, over a two ye...

  3. 222名农村糖尿病患者相关知识调查研究%222 Rural People with Diabetes Related Knowledge Study

    Institute of Scientific and Technical Information of China (English)

    傅娜; 杨瑞贞; 陈培培; 刘敏

    2013-01-01

    目的了解农村糖尿病患者对糖尿病相关知识的掌握情况,为改进农村糖尿病健康教育提供依据。方法采用自行编制的"农村糖尿病患者糖尿病相关知识的调查问卷"对222例农村糖尿病患者进行问卷调查。结果有50%以上的农村糖尿病患者对糖尿病的相关知识缺乏了解,掌握程度远远不够。年龄、文化程度、病程、家庭月收入对农村糖尿病患者糖尿病相关知识的掌握的影响具有明显的差异:年龄越大糖尿病相关知识掌握情况越好,文化程度越高知识掌握程度也越高,病程越长对糖尿病的并发症的了解程度越高,家庭月收入越低对糖尿病知识掌握越差。结论加强农村糖尿病患者糖尿病知识教育是防治糖尿病的最重要的措施。通过系统的健康教育,使农村糖尿病患者最大程度的获得糖尿病知识,认识到糖尿病的危害,建立科学的生活方式,对有效控制糖尿病的发生发展具有重要意义。%Objective To know the situation of understanding the related diabetes knowledge between the rural diabetes patients,and provide with bases for perfecting the health education of diabetics. Methods A questionnaire investigation was conducted among 220 patients with the self-designed questionnaire. Results More than half of the rural diabetes patients are lack of understanding about the relevant knowledge of diabetes. The cognition、cultural degree、level、monthly income have influence for diabetes knowledge between the rural diabetes patients:The older cognition,the the more knowledge of diabetes they master. The higher level of education of knowledge of diabetes master degree,the bet er. The longer duration of diabetes understand the diabetes complications bet er. The higher the monthly income of a family owns,the more knowledge of diabetes they master. Conclusion To strengthen the diabetes knowledge education of the rural diabetes patiengs is the

  4. The HIV-1 Tat protein modulates CD4 expression in human T cells through the induction of miR-222

    Science.gov (United States)

    Orecchini, Elisa; Doria, Margherita; Michienzi, Alessandro; Giuliani, Erica; Vassena, Lia; Ciafrè, Silvia Anna; Farace, Maria Giulia; Galardi, Silvia

    2014-01-01

    Several cellular microRNAs show substantial changes in expression during HIV-1 infection and their active role in the viral life cycle is progressively emerging. In the present study, we found that HIV-1 infection of Jurkat T cells significantly induces the expression of miR-222. We show that this induction depends on HIV-1 Tat protein, which is able to increase the transcriptional activity of NFkB on miR-222 promoter. Moreover, we demonstrate that miR-222 directly targets CD4, a key receptor for HIV-1, thus reducing its expression. We propose that Tat, by inducing miR-222 expression, complements the CD4 downregulation activity exerted by other viral proteins (i.e., Nef, Vpu, and Env), and we suggest that this represents a novel mechanism through which HIV-1 efficiently represses CD4 expression in infected cells. PMID:24717285

  5. The HIV-1 Tat protein modulates CD4 expression in human T cells through the induction of miR-222.

    Science.gov (United States)

    Orecchini, Elisa; Doria, Margherita; Michienzi, Alessandro; Giuliani, Erica; Vassena, Lia; Ciafrè, Silvia Anna; Farace, Maria Giulia; Galardi, Silvia

    2014-01-01

    Several cellular microRNAs show substantial changes in expression during HIV-1 infection and their active role in the viral life cycle is progressively emerging. In the present study, we found that HIV-1 infection of Jurkat T cells significantly induces the expression of miR-222. We show that this induction depends on HIV-1 Tat protein, which is able to increase the transcriptional activity of NFkB on miR-222 promoter. Moreover, we demonstrate that miR-222 directly targets CD4, a key receptor for HIV-1, thus reducing its expression. We propose that Tat, by inducing miR-222 expression, complements the CD4 downregulation activity exerted by other viral proteins (i.e., Nef, Vpu, and Env), and we suggest that this represents a novel mechanism through which HIV-1 efficiently represses CD4 expression in infected cells. PMID:24717285

  6. Mapping of regions participating in replication, maintenance, and mobilization of the broad host range R plasmid pBS222

    International Nuclear Information System (INIS)

    As a result of analysis of the deletion derivatives, obtained in vitro by sodium bisulfite mutagenesis and cloned within the pUC19 vector regions of the broad host-range plasmid pBS222, genes participating in replication, maintenance, and mobilization of the plasmids have been mapped in a region with coordinates 0.2-2.5 kb and an area including the unique HindIII restriction site (12.3 kb). The derivatives pBS359, pBS361, and pBS362 belong to the smallest broad host-range plasmids. The authors have identified three polypeptides (molecular weights ∼ 15, 25, and 30 kdalton), two of which presumably participate in the provision of the broad host-range functions, and the other in the mobilization of plasmid pBS222. The possibility of molecular and genetic organization of plasmid pBS222 and the presence of recombination hot points and also the prospects of using this method for the preparation of vector derivatives are discussed

  7. Occurrence of {sup 222}Rn in irrigation water from Wadi Al-Rummah Qassim province, Saudi Arabia

    Energy Technology Data Exchange (ETDEWEB)

    El-Taher, Atef; Alashrah, Saleh [Physics department, College of Science, Qassim University, P. O. 6644, Buraidah 51452 (Saudi Arabia)

    2015-08-28

    Naturally accruing radioactive materials in the environment have received attention since they may be present in high level and pose risk to human health. The present work deals with measuring of {sup 222}Rn in irrigation water samples from Wadi Al-Rummah, Qassim province, in central of Saudi Arabia. {sup 222}Rn concentrations were measured by RAD7. It was found that the concentration of {sup 222}Rn ranged from 2.1 ± 1.2 to 7.2 ± 1.5 BqL{sup −1}. These values are below 11.1 BqL{sup −1} the maximum contamination level recommended from the U.S. Environmental Protection Agency. The calculated annual effective dose (AED) ranging from 7.5 to 26.1 µSv/y. It was evident that the total annual effective dose resulting from radon in irrigation groundwater in Wadi Al-Rummah in Qassim area were significantly lower than the recommended limit 1 mSv/y for the public.

  8. Seasonal variation of 222Rn in seawater samples from Ubatuba embayments, SP, Brazil, for the assessment of submarine groundwater discharge

    International Nuclear Information System (INIS)

    We describe here an application of excess 222Rn to estimate SGD in a series of small embayments of Ubatuba, Sao Paulo State, Brazil, covering latitudes between 23 deg 26'S and 23 deg 46'S and longitudes between 45 deg 02'W e 45 deg 11'W. Excess 222Rn inventories obtained in 24 vertical profiles established from March/03 to July/05 varied from 345 ±±24 to 18,700 ± 4,900 dpm/m2. The highest inventories of excess 222Rn were observed both in Flamengo and Fortaleza embayments, during summer campaigns (rainy season). The estimated total fluxes required to support inventories measured varied from 62 ± 4 to 3,385 +- 880 dpm/m2 d. Considering these results, the SGD advective rates necessary to balance the fluxes calculated in Ubatuba embayments ranged from 0.1 x 10-1 to 1.9 cm/d. Taking into account all SGD fluxes obtained, the percentual variability was 89% (seasonal variation in 3 years period, n = 24 measurements). Although, if we consider each year of study separately, the respective percentual variabilities estimated are 72% in 2003 (n = 10 measurements), 127% in 2004 (n = 6 measurements) and 97% in 2005 (n = 8 measurements). (author)

  9. Seasonal variations of CO2 and 222Rn in a mediterranean sinkhole - spring (Causse d’Aumelas, SE France

    Directory of Open Access Journals (Sweden)

    Batiot-Guilhe Christelle

    2007-01-01

    Full Text Available Carbon dioxide and 222Rn monitoring of the atmosphere of a Mediterranean sink hole - spring (SE France during two hydrological cycles (from September 2004 to September 2006 showed seasonal variations with very high concentrations during summer (greater than 6% and 20 000 Bq/m3, respectively. Gas dynamics in caves often show seasonal variations.Meteorological parameters (barometric pressure and temperature mainly, cave geometry and fracture networks control exchanges between the cavity and outside atmosphere. Carbon dioxide and 222Rn may have different sources (atmosphere, soil, bedrock, deep gas diffusion, in situ oxidation of organic matter and, in some caves, the key role of swift underground streams.For a CO2 origin, 13C measurements on water and gas samples taken into the cavity suggest a superficial origin. Radon-222 appears to be locally produced and transported by biogenic CO2. Further investigations will be carried out in order to study the relationship of gas-level variations with barometric pressure variations and piezometric level fluctuations within the aquifer.

  10. Precise measurement of the 222Rn half-life: A probe to monitor the stability of radioactivity

    Directory of Open Access Journals (Sweden)

    E. Bellotti

    2015-04-01

    Full Text Available We give the results of a study on the 222Rn decay we performed in the Gran Sasso Laboratory (LNGS by detecting the gamma rays from the radon progeny. The motivation was to monitor the stability of radioactivity measuring several times per year the half-life of a short lifetime (days source instead of measuring over a long period the activity of a long lifetime (tens or hundreds of years source. In particular, we give a possible reason of the large periodical fluctuations in the count rate of the gamma rays due to radon inside a closed canister which has been described in literature and which has been attributed to a possible influence of a component in the solar irradiation affecting the nuclear decay rates. We then provide the result of four half-life measurements we performed underground at LNGS in the period from May 2014 to January 2015 with radon diffused into olive oil. Briefly, we did not measure any change of the 222Rn half-life with a 8⋅10−5 precision. Finally, we provide the most precise value for the 222Rn half-life: 3.82146(16stat(4syst days.

  11. Virulence-associated substitution D222G in the hemagglutinin of 2009 pandemic influenza A(H1N1) virus affects receptor binding

    NARCIS (Netherlands)

    S. Chutinimitkul (Salin); S. Herfst (Sander); J. Steel (John); A.C. Lowen (Anice); J. Ye (Jian); D.A.J. van Riel (Debby); E.J.A. Schrauwen (Eefje); T.M. Bestebroer (Theo); B.F. Koel (Björn); D.F. Burke (David); K.H. Sutherland-Cash (Kyle); C.S. Whittleson (Chris); C.A. Russell (Colin); D.J. Wales (David); D.J. Smith (Derek); M. Jonges (Marcel); A. Meijer (Adam); M. Koopmans (Matty); G.F. Rimmelzwaan (Guus); T. Kuiken (Thijs); A.D.M.E. Osterhaus (Albert); A. García-Sastre (Adolfo); D.R. Perez (Daniel); R.A.M. Fouchier (Ron)

    2010-01-01

    textabstractThe clinical impact of the 2009 pandemic influenza A(H1N1) virus (pdmH1N1) has been relatively low. However, amino acid substitution D222G in the hemagglutinin of pdmH1N1 has been associated with cases of severe disease and fatalities. D222G was introduced in a prototype pdmH1N1 by rever

  12. Measurements of Rn-222, Rn-220 and their decay products in the environmental air of the high background radiation areas in Yangjiang, China.

    Science.gov (United States)

    Yuan, Y; Morishima, H; Shen, T; Koga, T; Wei, L; Sugahara, T

    2000-10-01

    For the renewal of dose estimation from internal irradiation in the high background radiation areas (HBRA) of Yangjiang, the measurements of radon, thoron and their decay products in the environmental air were conducted, including: (1) integrating measurements of Rn-222 and Rn-220 concentrations; (2) eqilibrium factor F for Rn-222 and alpha-potential energy value of Rn-220; (3) external gamma radiation in places where radon measurements were undertaken; (4) cumulative exposure to indoor radon for each family in a case-control study on lung cancer. The Rn-Tn cup monitor method was used for the integrating measurement of Rn-222 and Rn-220 concentration. An alpha track detector was used for the integration measurement of Rn-222 concentration in the case-control study on lung cancer. The results of measurements show that although the investigated areas are located between the Equator and the Tropic of Cancer, and that people live in well-ventilated dwellings, the concentrations of radon, especially of Rn-220 are significantly higher in the indoor air of HBRA than those in the control area. The value of equilibrium factors for Rn-222, the alpha potential energy of decay products from Rn-222 and Rn-220 are determined.

  13. Measurements of Rn-222, Rn-220 and their decay products in the environmental air of the high background radiation areas in Yangjiang, China

    Energy Technology Data Exchange (ETDEWEB)

    Yuan Yongling; Shen Tong [Labor Hygiene Inst. of Human Province, Changsha (China); Morishima, Hiroshige; Koga, Taeko; Wei Luxin; Sugahara, Tsutomu

    2000-10-01

    For the renewal of dose estimation from internal irradiation in the high background radiation areas (HBRA) of Yangjiang, the measurements of radon, thoron and their decay products in the environmental air were conducted, including: integrating measurements of Rn-222 and Rn-220 concentrations; equilibrium factor F for Rn-222 and alpha-potential energy value of Rn-220; external gamma radiation in places where radon measurements were undertaken; cumulative exposure to indoor radon for each family in a case-control study on lung cancer. The Rn-Tn cup monitor method was used for the integrating measurement of Rn-222 and Rn-220 concentration. An alpha track detector was used for the integration measurement of Rn-222 concentration in the case-control study on lung cancer. The results of measurements show that although the investigated areas are located between the Equator and the Tropic of Cancer, and that people live in well-ventilated dwellings, the concentrations of radon, especially of Rn-220 are significantly higher in the indoor air of HBRA than those in the control area. The value of equilibrium factors for Rn-222, the alpha potential energy of decay products from Rn-222 and Rn-220 are determined. (author)

  14. The role of mesoscale meteorology in modulating the (222)Rn concentrations in Huelva (Spain)--impact of phosphogypsum piles.

    Science.gov (United States)

    Hernández-Ceballos, M A; Vargas, A; Arnold, D; Bolívar, J P

    2015-07-01

    The combined analysis of (222)Rn activity concentrations and mesoscale meteorological conditions at Huelva city (Spain) was addressed in this study to understand the potential impact of phosphogypsum piles on the (222)Rn activity concentrations registered at this area. Hourly mean data from April 2012 to February 2013 registered at two sampling sites (Huelva city and in the background station of El Arenosillo, located 27 km to the south-east) have been used in the study. The results of the present study showed a large difference in mean radon concentrations between the two stations during the sampling period, 6.3 ± 0.4 Bq m(-3) at Huelva and 3.0 ± 0.2 Bq m(-3) at El Arenosillo. The analysis has demonstrated that hourly (222)Rn concentrations at Huelva city above 22 Bq m(-3), with nocturnal peaks up to 50 Bq/m(3), mainly coincided with the occurrence of a pure sea-land breeze cycle. Mesoscale circulations in this region are mainly characterized by two patterns of sea-land breeze, pure and non-pure, with the phosphosypsum piles directly upstream (south) of the city during the afternoon on pure sea-breeze days. The difference between mean (222)Rn activity concentrations at Huelva city were 9.9 ± 1.5 Bq m(-3) for the pure pattern and 3.3 ± 0.5 Bq m(-3) for the non-pure pattern, while in the background station concentrations were 3.9 ± 0.4 Bq m(-3) and 2.8 ± 0.4 Bq m(-3) respectively. Considering these large differences, a detailed analysis of composites and case studies of representative sea-land breeze cycles of both types and their impact on (222)Rn activity concentration was performed. The results suggested that the presence of the phosphogypsum piles was necessary in order to justify the high (222)Rn activity concentrations observed at Huelva compared with the background station in the afternoons on pure sea breeze days (1.5-2.0 Bq m(-3)). On the other hand, large night time differences between the two sites on these days were

  15. Occurrence of Uranium and 222Radon in Glacial and Bedrock Aquifers in the Northern United States, 1993-2003

    Science.gov (United States)

    Ayotte, Joseph D.; Flanagan, Sarah M.; Morrow, William S.

    2007-01-01

    Water-quality data collected from 1,426 wells during 1993-2003 as part of the U.S. Geological Survey National Water-Quality Assessment (NAWQA) program were evaluated to characterize the water quality in glacial and bedrock aquifers of the northern United States. One of the goals of the NAWQA program is to synthesize data from individual studies across the United States to gain regional- and national-scale information about the behavior of contaminants. This study focused on the regional occurrence and distribution of uranium and 222radon in ground water in the glacial aquifer system of the United States as well as in the Cambrian-Ordovician and the New York and New England crystalline aquifer systems that underlie the glacial aquifer system. The occurrence of uranium and 222radon in ground water has long been a concern throughout the United States. In the glacial aquifers, as well as the Cambrian-Ordovician and the New York and New England crystalline aquifer systems of the United States, concentrations of uranium and 222radon were highly variable. High concentrations of uranium and 222radon affect ground water used for drinking water and for agriculture. A combination of information or data on (1) national-scale ground-water regions, (2) regional-scale glacial depositional models, (3) regional-scale geology, and (4) national-scale terrestrial gamma-ray emissions were used to confirm and(or) refine the regions used in the analysis of the water-chemistry data. Significant differences in the occurrence of uranium and 222radon, based primarily on geologic information were observed and used in this report. In general, uranium was highest in the Columbia Plateau glacial, West-Central glacial, and the New York and New England crystalline aquifer groups (75th percentile concentrations of 22.3, 7.7, and 2.9 micrograms per liter (ug/L), respectively). In the Columbia Plateau glacial and the West-Central glacial aquifer groups, more than 10 percent of wells sampled had

  16. 222 Rn exposure assessment in the caves of Parque Estadual Turistico do Alto Ribeira (PETAR)

    International Nuclear Information System (INIS)

    In the present work, radon concentrations in six caves of PETAR - Parque Estadual Turistico do Alto Ribeira (High Ribeira River Touristic State Park) were carried out with Makrofol E solid state nuclear track detectors (SSNTD) and used to assess the annual effective dose received by regional tour guides. The park has four visitation centers: Santana, Ouro Grosso, Caboclos e Casa de Pedra and receives nearly 40,000 people annually. The caves evaluated were Couto, Agua Suja, Laje Branca, Morro Preto and Santana, from Santana center and Alambari de Baixo from Ouro Grosso center, for being the most frequently visited caves. The exposure period of the SSNTD was, at least, three months, over a period of 26 months, from October 2003 to November 2005.The 222Rn concentrations lay in a range from 153 Bq.m-3 to 6607 Bq.m-3 and we observed that, in general, for chilly weather, the radon levels decrease. The annual effective dose, considering the most realistic scenario, with geometric mean concentrations, an equilibrium factor of 0.5 and annual exposure time for each cave, varied from 0.2 mSv.a-1 for the Couto cave, strongly ventilated, to 4.0 mSv.a-1 for the Santana cave, the most frequently visited and no external communication. For the worst scenario, with arithmetic mean concentrations, equilibrium factor 1 and annual exposure time for all caves, the annual effective dose was 16.1 mSv.a-1. All assessed effective doses received by the tour guides are bellow 20 mSv.a-1 suggested as an annual effective dose limit for occupational exposure by the International Commission of Radiological Protection (ICRP 60, 1990). (author)

  17. Optimized measurement of radium-226 concentration in liquid samples with radon-222 emanation.

    Science.gov (United States)

    Perrier, Frédéric; Aupiais, Jean; Girault, Frédéric; Przylibski, Tadeusz A; Bouquerel, Hélène

    2016-06-01

    Measuring radium-226 concentration in liquid samples using radon-222 emanation remains competitive with techniques such as liquid scintillation, alpha or mass spectrometry. Indeed, we show that high-precision can be obtained without air circulation, using an optimal air to liquid volume ratio and moderate heating. Cost-effective and efficient measurement of radon concentration is achieved by scintillation flasks and sufficiently long counting times for signal and background. More than 400 such measurements were performed, including 39 dilution experiments, a successful blind measurement of six reference test solutions, and more than 110 repeated measurements. Under optimal conditions, uncertainties reach 5% for an activity concentration of 100 mBq L(-1) and 10% for 10 mBq L(-1). While the theoretical detection limit predicted by Monte Carlo simulation is around 3 mBq L(-1), a conservative experimental estimate is rather 5 mBq L(-1), corresponding to 0.14 fg g(-1). The method was applied to 47 natural waters, 51 commercial waters, and 17 wine samples, illustrating that it could be an option for liquids that cannot be easily measured by other methods. Counting of scintillation flasks can be done in remote locations in absence of electricity supply, using a solar panel. Thus, this portable method, which has demonstrated sufficient accuracy for numerous natural liquids, could be useful in geological and environmental problems, with the additional benefit that it can be applied in isolated locations and in circumstances when samples cannot be transported. PMID:26998570

  18. Optimized measurement of radium-226 concentration in liquid samples with radon-222 emanation.

    Science.gov (United States)

    Perrier, Frédéric; Aupiais, Jean; Girault, Frédéric; Przylibski, Tadeusz A; Bouquerel, Hélène

    2016-06-01

    Measuring radium-226 concentration in liquid samples using radon-222 emanation remains competitive with techniques such as liquid scintillation, alpha or mass spectrometry. Indeed, we show that high-precision can be obtained without air circulation, using an optimal air to liquid volume ratio and moderate heating. Cost-effective and efficient measurement of radon concentration is achieved by scintillation flasks and sufficiently long counting times for signal and background. More than 400 such measurements were performed, including 39 dilution experiments, a successful blind measurement of six reference test solutions, and more than 110 repeated measurements. Under optimal conditions, uncertainties reach 5% for an activity concentration of 100 mBq L(-1) and 10% for 10 mBq L(-1). While the theoretical detection limit predicted by Monte Carlo simulation is around 3 mBq L(-1), a conservative experimental estimate is rather 5 mBq L(-1), corresponding to 0.14 fg g(-1). The method was applied to 47 natural waters, 51 commercial waters, and 17 wine samples, illustrating that it could be an option for liquids that cannot be easily measured by other methods. Counting of scintillation flasks can be done in remote locations in absence of electricity supply, using a solar panel. Thus, this portable method, which has demonstrated sufficient accuracy for numerous natural liquids, could be useful in geological and environmental problems, with the additional benefit that it can be applied in isolated locations and in circumstances when samples cannot be transported.

  19. Discovery of a deep Seyfert-2 galaxy at z = 0.222 behind NGC 300

    Science.gov (United States)

    Combi, J. A.; García, F.; Rodríguez, M. J.; Gamen, R.; Cellone, S. A.

    2016-08-01

    We report on the unveiling of the nature of the unidentified X-ray source 3XMM J005450.3-373849 as a Seyfert-2 galaxy located behind the spiral galaxy NGC 300 using Hubble Space Telescope data, new spectroscopic Gemini observations and available XMM-Newton and Chandra data. We show that the X-ray source is positionally coincident with an extended optical source, composed of a marginally resolved nucleus/bulge, surrounded by an elliptical disc-like feature and two symmetrical outer rings. The optical spectrum is typical of a Seyfert-2 galaxy redshifted to z = 0.222 ± 0.001, which confirms that the source is not physically related to NGC 300. At this redshift the source would be located at 909 ± 4 Mpc (comoving distance in the standard model). The X-ray spectra of the source are well fitted by an absorbed power-law model. By tying NH between the six available spectra, we found a variable index Γ running from ˜2 in 2000-2001 to 1.4-1.6 in the 2005-2014 period. Alternatively, by tying Γ, we found variable absorption columns of NH ˜ 0.34 × 10-22 cm-2 in 2000-2001, and 0.54-0.75 × 10-22 cm-2 in the 2005-2014 period. Although we cannot distinguish between a spectral or absorption origin, from the derived unabsorbed X-ray fluxes, we are able to assure the presence of long-term X-ray variability. Furthermore, the unabsorbed X-ray luminosities of 0.8-2 × 1043 erg s-1 derived in the X-ray band are in agreement with a weakly obscured Seyfert-2 AGN at z ≈ 0.22.

  20. Contribution of 222Rn-bearing water to indoor radon and indoor air quality assessment in hot spring hotels of Guangdong, China

    International Nuclear Information System (INIS)

    This study investigates the contribution of radon (222Rn)-bearing water to indoor 222Rn in thermal baths. The 222Rn concentrations in air were monitored in the bathroom and the bedroom. Particulate matter (PM, both PM10 and PM2.5) and carbon dioxide (CO2) were also monitored with portable analyzers. The bathrooms were supplied with hot spring water containing 66-260 kBq m-3 of 222Rn. The results show that the spray of hot spring water from the bath spouts is the dominant mechanism by which 222Rn is released into the air of the bathroom, and then it diffuses into the bedroom. Average 222Rn level was 110-410% higher in the bedrooms and 510-1200% higher in the bathrooms compared to the corresponding average levels when there was no use of hot spring water. The indoor 222Rn levels were influenced by the 222Rn concentrations in the hot spring water and the bathing times. The average 222Rn transfer coefficients from water to air were 6.2 x 10-4-4.1 x 10-3. The 24-h average levels of CO2 and PM10 in the hotel rooms were 89% and 22% higher than the present Indoor Air Quality (IAQ) standard of China. The main particle pollutant in the hotel rooms was PM2.5. Radon and PM10 levels in some hotel rooms were at much higher concentrations than guideline levels, and thus the potential health risks to tourists and especially to the hotel workers should be of great concern, and measures should be taken to lower inhalation exposure to these air pollutants. - Highlights: → 222Rn-bearing water is the main contributor to indoor radon in hot spring hotel. → The PM2.5 and CO2 are also the main indoor pollutants in the hotel rooms. → Higher radon and PM levels might have significant negative health effects to human. → The radon transfer coefficients are consistent with the published data.

  1. Hemagglutinin 222D/G polymorphism facilitates fast intra-host evolution of pandemic (H1N1 2009 influenza A viruses.

    Directory of Open Access Journals (Sweden)

    Nora Seidel

    Full Text Available The amino acid substitution of aspartic acid to glycine in hemagglutinin (HA in position 222 (HA-D222G as well as HA-222D/G polymorphism of pandemic (H1N1 2009 influenza viruses (A(H1N1pdm09 were frequently reported in severe influenza in humans and mice. Their impact on viral pathogenicity and the course of influenza has been discussed controversially and the underlying mechanism remained unclarified. In the present study, BALB/c mice, infected with the once mouse lung- and cell-passaged A(H1N1pdm09 isolate A/Jena/5258/09 (mpJena/5258, developed severe pneumonia. From day 2 to 3 or 4 post infection (p.i. symptoms (body weight loss and clinical score continuously worsened. After a short disease stagnation or even recovery phase in most mice, severity of disease further increased on days 6 and 7 p.i. Thereafter, surviving mice recovered. A 45 times higher virus titer maximum in the lung than in the trachea on day 2 p.i. and significantly higher tracheal virus titers compared to lung on day 6 p.i. indicated changes in the organ tropism during infection. Sequence analysis revealed an HA-222D/G polymorphism. HA-D222 and HA-G222 variants co-circulated in lung and trachea. Whereas, HA-D222 variant predominated in the lung, HA-G222 became the major variant in the trachea after day 4 p.i. This was accompanied by lower neutralizing antibody titers and broader receptor recognition including terminal sialic acid α-2,3-linked galactose, which is abundant on mouse trachea epithelial cells. Plaque-purified HA-G222-mpJena/5258 virus induced severe influenza with maximum symptom on day 6 p.i. These results demonstrated for the first time that HA-222D/G quasispecies of A(H1N1pdm09 caused severe biphasic influenza because of fast viral intra-host evolution, which enabled partial antibody escape and minor changes in receptor binding.

  2. miR-222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27(kip1) expression.

    Science.gov (United States)

    Wang, Dan-Dan; Li, Jian; Sha, Huan-Huan; Chen, Xiu; Yang, Su-Jin; Shen, Hong-Yu; Zhong, Shan-Liang; Zhao, Jian-Hua; Tang, Jin-Hai

    2016-09-15

    Adriamycin (Adr) is a potent chemotherapeutic agent for chemotherapy of breast cancer patients. Despite impressive initial clinical responses, some developed drug resistance to Adr-based therapy and the mechanisms underlying breast cancer cells resistance to Adr are not well known. In our previous study, in vitro, we verified that miR-222 was upregulated in Adr-resistant breast cancer cells (MCF-7/Adr) compared with the sensitive parental cells (MCF-7/S). Here, miR-222 inhibitors or mimics were transfected into MCF-7 cell lines. RT-qPCR and western blot were used to detect the expression of p27(kip1). Immunofluorescence showed that miR-222 altered the subcellular location of p27(kip1) in nucleus. MTT was employed to verify the sensitivity of breast cancer cell lines to Adr. Flow cytometry showed the apoptosis and cell cycles of the cells after adding Adr. The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis, and arrested the cells in G1 phase, accompanied by more expressions of p27(kip1), especially in nucleus. Furthermore, overexpressed miR-222 in MCF-7/S had the inverse results. Taken together, the results found that miR-222 induced Adr-resistance at least in part via suppressing p27(kip1) expression and altering its subcellular localization, and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells. These results disclosed that the future holds much promise for the targeted therapeutic in the treatment of Adr-resistant breast cancer. PMID:27282281

  3. Analyses of atmospheric radon 222 / canisters exposed by Greenpeace in Niger (Arlit / Akokan sector); Analyses du radon 222 dans l'air ambiant / Capteurs exposes par Greenpeace au Niger (secteur Arlit et Akokan)

    Energy Technology Data Exchange (ETDEWEB)

    Chareyron, B.

    2010-07-01

    The companies SOMAIR and COMINAK, subsidiaries of the AREVA group, are mining uranium deposits in northern Niger. In the course of a field mission carried out in November 2009, a Greenpeace International team deposited detectors (canisters of activated charcoal) to measure radon 222, a radioactive gas formed by the decay of the radium 226 present in the uranium ore. This report includes the results of the analysis of the activated charcoal canisters conducted in CRIIRAD's laboratory, and a brief commentary on the interpretation of the results. (authors)

  4. Concentrations of Ra-226 and Rn-222 in Thermal Groundwater Measured by Emanation-scintillation Method%射气闪烁法测定地下热水的镭-226和氡-222浓度

    Institute of Scientific and Technical Information of China (English)

    李婷; 周训; 龙汨; 王晓翠; 陈婷; 李婧玮; 杨苗林

    2014-01-01

    High radioactive concentrations of 226 Ra and 222 Rn in thermal groundwater are of important significance in studying formation and circulation of thermal groundwater. The experimental apparatus,measurement principle and steps,pre-treatment of water samples and result calculations of the emanation-scintillation method to measure the radioactive concentrations of 226 Ra and 222 Rn in thermal groundwater in laboratory were described,and the determination of parameters used in the experimental devices and the measuring methods were discussed.The results show that the optimal threshold electric pressure for the radioactive FD-125 radonvthorium analyzer used in the experiment is 2 V,and the corresponding optimal working high electric pressure is 450 V;the collection factors for the three scintillation chambers used are 0.005 428,0.005 567 and 0.005 060,respectively;when 226 Ra is extracted from water sample in the pre-treatment,the pH values are controlled in the range of 2.5-3.0 in order to obtain the maximum method recovery rate.%地下热水中放射性浓度较高的226 Ra 和222 Rn 对于研究地下热水的形成和循环具有重要的意义.阐明了实验室测定地下热水226 Ra 和222 Rn 放射性浓度的射气闪烁法的仪器组成、测试原理、测试步骤、水样前处理和结果换算,讨论了在测试过程中各仪器和试验方法所需参数的选取及确定的具体操作.结果表明:在本试验中,所用放射性测试仪器 FD-125型氡钍分析仪的最佳阈电压为2 V,对应的最佳工作高压为450 V;所采用的3个闪烁室的校正因子分别为0.005428、0.005567和0.005060;进行前处理提取水样226 Ra时,pH 值应控制在2.5~3.0之间,可确保方法回收率最大.

  5. {sup 222} Rn determination and physicochemical characteristic and biological in aquifers in the Toluca Valley; Determinacion de {sup 222} Rn y caracteristicas fisicoquimicas y biologicas en acuiferos del Valle de Toluca

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez A, A

    1998-10-01

    Concentration levels of {sup 222} Rn and {sup 226} Rn have been analyzed in water samples from boreholes belonging to the drinking water supply system around Toluca, Mexico. The {sup 222} Rn source is the decay of {sup 226} Rn within the solid matrix of the aquifer. The study was performed during the dry and rainy seasons. {sup 222} Rn concentration was determined by the liquid scintillation technique, {sup 226} Rn was determined by gamma spectrometry, the physicochemical parameters and bacteriological analysis were performed by conventional chemical techniques. Solubilized trace elements were determined by Inductively Coupled Plasma - Mass Spectrometry (Icp-Ms). The radon level fluctuations at the boreholes in Toluca city and Almoloya spring indicated differences in the radon content. At borehole Lodos Prietos 2, the temperature and radon level were systematically the highest in comparison with the other boreholes and the spring indicating a contribution of a regional flow to the water of this particular borehole. The result for {sup 226} Rn, the average {sup 222} Rn observed during the sampling period, no correspondence occurs between the radium and the radon content indicating that, radon is not supported by radium, but is incorporated into the water through fissures in the rocks in contact with the water. The radon levels obtained in house faucets which water is supplied by boreholes decrease as a function of the distance from the source borehole to the house. With the chemical composition of each one of the studied boreholes and spring a Piper diagram was draw indicating the kind of water. The boreholes and spring can be classified as bicarbonate calcium/magnesium. Almost no fluctuation on time was observed in the chemical species and trace elements only a slight increase was observed at the end of the rain season. At Almoloya, spring pollution with coliform bacteria and nitrates showed an anthropogenic contribution to the water deterioration probable and

  6. Evolution of {sup 222} Rn and chemical species related with eruptive processes of the Popocatepetl volcano; Evolucion de {sup 222} Rn y especies quimicas relacionadas con procesos eruptivos del volcan Popocatepetl

    Energy Technology Data Exchange (ETDEWEB)

    Aranda, P.; Ceballos, S.; Cruz, D.; Hernandez, A.; Lopez, R.; Pena, P.; Salazar, S.; Segovia, N.; Tamez, E. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    The {sup 222} Rn monitoring in the Popocatepetl volcano was initiated on 1993. At December 21, 1994 it is initiated an eruptive stage in the volcano with gas emission, ashes and the lava dome formation on the crater at middle 1996. During all this time it has been determined radon concentrations on soils with active and passive detectors. In this work the changes in radon contents are reported also the physicochemical parameters in spring water related with the volcanic building associated to the recent activity of the volcano. (Author)

  7. Dose to tissues and effective dose equivalent by inhalation of radon-222, radon-220 and their short-lived daughters

    International Nuclear Information System (INIS)

    In this study the results of a sensitivity analysis are described which shows the influence of relevant physical and biological parameters on the dose from inhaled Rn-222, Rn-220 and their daughters to the basal cell layer of the bronchi, to the pulmonary tissues and to other body tissues. The used models for deposition, retention and dosimetry of inhaled daughters take into regard the variation of following parameters: The AMAD of inhaled radioactive particles; the fraction of unattached daughters atoms; the velocity of ciliary transport; the desorption rate of attached daughter atoms from their particles; the absorption rate to blood; and the depth of the basal cell layer in the bronchial generations. A computer programme was set-up for the calculation of the activity and dose distribution in the lungs as function of these parameters. For the evaluation of the effective dose from inhaled mixtures of Rn-222- and Rn-220-daughters three different alternatives for the weighting of the mean doses to the target tissues in the lungs are described, taking into regard possible differences between the cancerogenic sensitivity of the target cells in the bronchial and alveolar region. On the basis of the results of this sensitivity analysis mean values for the effective dose to adults per unit of inhaled potential α-energy (in Joule) and per unit of potential α-energy (in WLM) of daughters mixtures are derived as function of the unattached fraction of potential α-energy in air and the desorption half-life time of attached daughter atoms in the lungs. In addition the effective dose from inhaled Rn-222 and Rn-220 (+ Po-216) is estimated and compared with the effective dose from inhaled daughters. Finally the consequences for the assessment of intake and exposure limits for workers and for members of the public are outlined. (orig.)

  8. Analytical services: 222-S characterization of 242-A Evaporator Slurry, Campaign 94-1. Addendum 1A

    International Nuclear Information System (INIS)

    During the 242-A Evaporator's 94-1 campaign, five process samples were collected from the slurry stream for waste characterization. The five samples were collected over a 36 day time span, respectively on May 4, May 9, May 16, May 23, and June 9, 1994. Sample collections were performed per the protocol described in 242-A Evaporator Waste Analysis Plan, WHC-SD-WM-EV-060, Rev. 3 and in 242-A Evaporator Quality Assurance Project Plan, WHC-SD-WM-QAPP-009, Rev. 0. Slurry waste was characterized chemically and radiochemically by the Westinghouse Hanford Company, 222-S Laboratory as directed

  9. Analytical services: 222-S characterization of 242-A Evaporator Slurry, Campaign 94-1. Addendum 1A

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-13

    During the 242-A Evaporator`s 94-1 campaign, five process samples were collected from the slurry stream for waste characterization. The five samples were collected over a 36 day time span, respectively on May 4, May 9, May 16, May 23, and June 9, 1994. Sample collections were performed per the protocol described in 242-A Evaporator Waste Analysis Plan, WHC-SD-WM-EV-060, Rev. 3 and in 242-A Evaporator Quality Assurance Project Plan, WHC-SD-WM-QAPP-009, Rev. 0. Slurry waste was characterized chemically and radiochemically by the Westinghouse Hanford Company, 222-S Laboratory as directed.

  10. A simple method for calibration of Lucas scintillation cell counting system for measurement of 226Ra and 222Rn

    OpenAIRE

    N.K. Sethy; V.N. Jha; P.M. Ravi; Tripathi, R. M.

    2014-01-01

    Known quantity of radium from high grade ore solution was chemically separated and carefully kept inside the cavity of a Lucas Cell (LC). The 222Rn gradually builds up and attain secular equilibrium with its parent 226Ra. This gives a steady count after a suitable buildup period (>25 days). This secondary source was used to calibrate the radon counting system. The method is validated in by comparison with identical measurement with AlphaGuard Aquakit. The radon counting system was used to eva...

  11. Isothermal titration calorimetry study of a bistable supramolecular system: reversible complexation of cryptand[2.2.2] with potassium ions.

    Science.gov (United States)

    del Rosso, Maria G; Ciesielski, Artur; Colella, Silvia; Harrowfield, Jack M; Samorì, Paolo

    2014-09-15

    Isothermal titration calorimetry (ITC) is used to investigate the thermodynamics of the complexation of potassium ions by 1,10-diaza-4,7,13,16,21,24-hexaoxabicyclo[8.8.8]hexacosane (cryptand[2.2.2]) in aqueous solution. By changing the pH of the solution it was possible to trigger the reversible complexation/decomplexation of the cryptand in consecutive in situ experiments and to assess for the first time the use of ITC to monitor the thermodynamics of a bistable system.

  12. 238U, 232TH, AND 222RN concentration measured in various traditional medicinal plant preparation using nuclear track detectors

    International Nuclear Information System (INIS)

    Full text: 238U, 232Th, 222Rn concentrations were measured inside traditional medicinal plants preparations widely used by patients in classic and modern phyto therapy by using a technique based on the use of solid state nuclear track detectors. The intakes of these radionuclides have been determined for adult patients from the ingestion of the studied medical preparations. The influence of mass intake as well as pollution on the contents of the considered radionuclides was investigated. The resulting radiation doses to adult patients from the ingestion of the traditional medical preparations were evaluated.

  13. Mapping indoor radon-222 in Denmark: Design and test of the statistical model used in the second nationwide survey

    DEFF Research Database (Denmark)

    Andersen, C.E.; Ulbak, K.; Damkjær, A.;

    2001-01-01

    In Denmark, a new survey of indoor radon-222 has been carried out. 1-year alpha track measurements (CR-39) have been made in 3019 single-family houses. There are from 3 to 23 house measurements in each of the 275 municipalities. Within each municipality, houses have been selected randomly. One...... important outcome of the survey is the prediction of the fraction of houses in each municipality with an annual average radon concentration above 200 Bq m(-3). To obtain the most accurate estimate and to assess the associated uncertainties, a statistical model has been developed. The purpose of this paper...

  14. Comprehensive software for the assessment of {sup 222}Rn and {sup 220}Rn decay products based on air sampling measurements

    Energy Technology Data Exchange (ETDEWEB)

    Sima, Octavian [Physics Department, University of Bucharest, Bucharest-Magurele, P.O. Box MG-11, RO-077125 (Romania)], E-mail: octavian.sima@ik.fzk.de

    2009-05-15

    A computational tool dedicated to the measurement of {sup 222}Rn and {sup 220}Rn decay products by air sampling is presented. {alpha}- or {gamma}-spectrometry measurements, gross {alpha} or {beta} counting, as well as a combination of them are considered. Special attention is given to the evaluation of the uncertainty budget of the results. Besides typical applications in the analysis of experimental data, the software can be used for assessing the expected quality of a measurement protocol and for optimizing it, by generating and analyzing sets of realistic synthetic data.

  15. A detailed examination of the chemical, hydrological, and geological properties influencing the mobility of 222radon and parent radionuclides in groundwater

    International Nuclear Information System (INIS)

    This study examines hydrological, geological and geochemical controls on 222Rn variability in groundwater in the Front Range of Colorado. Specific objectives of the study are: (1) to determine if there are any correlations or spatial relationships between 222Rn and the geological, geochemical and hydrogeological data; and (2) to determine whether it is geochemically reasonable for observed 222Rn levels to be the result of U and 226Ra accumulation by fracture filling minerals. Domestic-water wells were sampled and tested to determine the local aquifer characteristics and aqueous geochemistry. A multivariate and staged approach was used in the data analyses. Analysis of variance tests were used to test for relationships between 222Rn and the lithology of the study wells. The effects of rock-type were then removed from the chemical and hydrological variables by subtracting the mean value for each rock-type from each of the measured values within that rock-type (a residual transformation). Linear and linear multiple regression techniques were used to test for expected relationships between residual 222Rn levels and these variables, and stepwise linear regressions were used to test for any unforeseen multivariate relationships in the data. Correlograms, distance-weighted average and inverse-distance-weighted average predictions were used to look for spatial relationships in the data

  16. Comparison of relationships between radon-222 concentration in outdoor air and some meteorological elements at different heights of the ground above sea level

    International Nuclear Information System (INIS)

    People living near uranium mine tailings, uranium mill tailings and the ventilation shaft of uranium mine are exposed to 222Rn and its short-lived daughters from general soil areas and those from specific sites. Therefore, it is necessary to descriminate between them to a certain degree. The diurnal variations of the 222Rn concentration in outdoor air, which is assumed to be in radioactive equilibrium with its short-lived daughters, are observed at three times by measuring 214Po using a surface-barrier detector at Okayama-shi and at Kamisaibara-mura. The heights of Okayama-shi and Kamisaibara-mura are about 1 m and about 710 m above sea level, respectively. Furthermore, some meteorological elements are simultaneously observed. It becomes clear and the variation patterns of the 222Rn concentration and the relationships between the 222Rn concentration and some meteorological elements are the same as the other sites except one run. Therefore, these suggest that it is possible to develop the method for the distinction between 222Rn and its short-lived daughters from the general soil areas and those from the specific sites without consideration of the height of the ground above sea level except the period of snowfall. (author)

  17. A detailed examination of the chemical, hydrological, and geological properties influencing the mobility of {sup 222}radon and parent radionuclides in groundwater

    Energy Technology Data Exchange (ETDEWEB)

    Sexsmith, K.S.

    1996-12-31

    This study examines hydrological, geological and geochemical controls on {sup 222}Rn variability in groundwater in the Front Range of Colorado. Specific objectives of the study are: (1) to determine if there are any correlations or spatial relationships between {sup 222}Rn and the geological, geochemical and hydrogeological data; and (2) to determine whether it is geochemically reasonable for observed {sup 222}Rn levels to be the result of U and {sup 226}Ra accumulation by fracture filling minerals. Domestic-water wells were sampled and tested to determine the local aquifer characteristics and aqueous geochemistry. A multivariate and staged approach was used in the data analyses. Analysis of variance tests were used to test for relationships between {sup 222}Rn and the lithology of the study wells. The effects of rock-type were then removed from the chemical and hydrological variables by subtracting the mean value for each rock-type from each of the measured values within that rock-type (a residual transformation). Linear and linear multiple regression techniques were used to test for expected relationships between residual {sup 222}Rn levels and these variables, and stepwise linear regressions were used to test for any unforeseen multivariate relationships in the data. Correlograms, distance-weighted average and inverse-distance-weighted average predictions were used to look for spatial relationships in the data.

  18. The activity concentrations of 222Rn and corresponding health risk in groundwater samples from basement and sandstone aquifer; the correlation to physicochemical parameters

    Science.gov (United States)

    Abdurabu, Wedad Ali; Ramli, Ahmad Termizi; Saleh, Muneer Aziz; Heryansyah, Arien

    2016-10-01

    This study aims to evaluate the activity concentrations of 222Rn and to assess the corresponding health risk in groundwater samples obtained in Juban District, Ad Dali' Governorate, Yemen. The measurements were performed by RAD 7 radon detector manufactured by DURRIDGE COMPANY Inc. The activity concentrations of 222Rn ranged from 1.0±0.2 Bq l-1 to 896.0±0.8 Bq l-1. 57% of the groundwater samples were above the US Environmental Protection Agency (USEPA) recommended value for Rn in water. Induced coupled plasma mass spectrometry (ICP-MS) was used to determine the concentrations of uranium in groundwater samples. The measured concentration of U ranged from 0.33±0.01 μg l-1 to 24.6±0.6 μg l-1. The results were comparable to internationally recommended values. The highest concentration of U and 222Rn were found to be in the basement aquifer, while the lowest concentrations of both radionuclides were in the sandstone aquifer. High concentrations of Rn are found along fault zones. The relationship between the activity concentration of 222Rn, concentration of U and physicochemical parameters were investigated. The results showed a very strong relationship between activity concentrations of 222Rn with concentrations of U and the salinity of water.

  19. Regulation of the p27Kip1 tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation

    Science.gov (United States)

    le Sage, Carlos; Nagel, Remco; Egan, David A; Schrier, Mariette; Mesman, Elly; Mangiola, Annunziato; Anile, Corrado; Maira, Giulio; Mercatelli, Neri; Ciafrè, Silvia Anna; Farace, Maria Giulia; Agami, Reuven

    2007-01-01

    MicroRNAs (miRNAs) are potent post-transcriptional regulators of protein coding genes. Patterns of misexpression of miRNAs in cancer suggest key functions of miRNAs in tumorigenesis. However, current bioinformatics tools do not entirely support the identification and characterization of the mode of action of such miRNAs. Here, we used a novel functional genetic approach and identified miR-221 and miR-222 (miR-221&222) as potent regulators of p27Kip1, a cell cycle inhibitor and tumor suppressor. Using miRNA inhibitors, we demonstrate that certain cancer cell lines require high activity of miR-221&222 to maintain low p27Kip1 levels and continuous proliferation. Interestingly, high levels of miR-221&222 appear in glioblastomas and correlate with low levels of p27Kip1 protein. Thus, deregulated expression of miR-221&222 promotes cancerous growth by inhibiting the expression of p27Kip1. PMID:17627278

  20. Continuous on-line calibration of diffusive soil-atmosphere trace gas transport using vertical {sup 220}Rn- and {sup 222}Rn-activity profiles

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, B.E. [Bern Univ. (Switzerland). Physics Inst.; Neftel, A. [Inst. of Environmental Protection and Agriculture, Bern (Switzerland); Tarakanov, S.V. [Inst. of Silicate Chemistry, St. Petersburg (Russian Federation)

    2001-07-01

    Continuous monitoring of {sup 220}Rn- and {sup 222}Rn-activities above and below the soil surface combined with sporadic direct {sup 222}Rn-flux measurements is used to quantify diffusive trace gas transport in the air-filled pore space of soil, through the soil-atmosphere interface and in the lowest layers of the atmosphere. In a calm night, {sup 222}Rn-activities above the surface first build-up near the ground (z < 10 cm) and subsequently with a delay of 2-3 hours at higher altitudes (z < 5 m). Knowing (1) the {sup 222}Rn-flux from activity profiles measured in soil gas, (2) from direct flux determinations and (3) using information about atmospheric diffusion parameters from {sup 220}Rn-activities measured near the surface it is possible to model the temporal evolution of the vertical {sup 222}Rn-profiles in a night with stable weather and constant soil conditions. The system operates automatically for extended periods of time in the field enabling a better understanding of transport processes in response to changing environmental conditions (wind, rain, soil humidity). (orig.)

  1. Assessment of {sup 222}Rn occupational exposure at IPEN nuclear materials storage site, SP, Brazil; Avaliacao da exposicao ocupacional ao {sup 222}Rn no galpao da Salvaguardas do IPEN, SP

    Energy Technology Data Exchange (ETDEWEB)

    Caccuri, Lilian Saueia

    2007-07-01

    In this study it was assessed the occupational exposure to {sup 222}Rn at IPEN, SP, Brazil, nuclear materials storage site through the committed effective dose received by workers exposed to this radionuclide. The radiation dose was calculated through the radon concentrations at nuclear materials storage site. Radon concentrations were determined by passive detection method with solid state nuclear detectors (SSNTD). The SSNTD used in this study was the polycarbonate Makrofol E; each detector is a small square plastic of 1 cm{sup 2}, placed into a diffusion chamber type KFK. It was monitored 14 points at nuclear materials storage site and one external point, over a period of 21 months, changing the detectors every three months, from December 2004 to September 2006. The {sup 222}Rn concentrations varied from 196 {+-} 9 and 2048 {+-} 81 Bq{center_dot}m{sup -3}. The committed effective dose due to radon inhalation at IPEN nuclear materials storage site was obtained from radon activity incorporated and dose conversion factor, according to International Commission on Radiological Protection procedures. The effective committed dose received by workers is below 20 mSv{center_dot}y{sup -1}. This value is suggested as an annual effective dose limit for occupational exposure by ICRP 60. (author)

  2. Precise measurement of the 222Rn half-life: a probe to monitor the stability of radioactivity

    CERN Document Server

    Bellotti, E; Di Carlo, G; Laubenstein, M; Menegazzo, R

    2015-01-01

    We give the results of a study on the 222Rn decay we performed in the Gran Sasso Laboratory (LNGS) by detecting the gamma rays from the radon progeny. The motivation was to monitor the stability of radioactivity measuring several times per year the half-life of a short lifetime (days) source instead of measuring over a long period the activity of a long lifetime (tens or hundreds of years) source. In particular, we give the reason of the large periodical fluctuations in the count rate of the gamma rays due to radon inside a closed canister which has been described in literature and which has been attributed to a possible influence of a component in the solar irradiation affecting the nuclear decay rates. We then provide the result of four half-life measurements we performed underground at LNGS in the period from May 2014 to January 2015 with radon diffused into olive oil. Briefly, we did not measure any change of the 222Rn half-life with a 8*10^-5 precision. Finally, we provide the most precise value for the ...

  3. Measurements of CO2, its stable isotopes, O2/N2, and 222Rn at Bern, Switzerland

    Directory of Open Access Journals (Sweden)

    P. Sturm

    2006-01-01

    Full Text Available A one-year time series of atmospheric CO2 measurements from Bern, Switzerland, is presented. O2/N2 and Ar/N2 ratios as well as stable carbon and oxygen isotopes of CO2 and δ29N2, δ34O2 and δ36Ar were measured periodically during a one year period. Additionally, the 222Rn activity was measured during three months in the winter 2004. Using the correlation from short-term fluctuations of CO2 and 222Rn we estimated a mean CO2 flux density between February 2004 and April 2004 in the region of Bern of 95±39 tC km–2month–1. The continuous observations of carbon dioxide and associated tracers shed light on diurnal and seasonal patterns of the carbon cycle in an urban atmosphere. There is considerable variance in nighttime δ13C and δ18O of source CO2 throughout the year, however, with generally lower values in winter compared to summertime. The O2:CO2 oxidation ratio during the nighttime build-up of CO2 varies between –0.96 and –1.69 mol O2/mol CO2. Furthermore, Ar/N2 measurements showed that artifacts like thermal fractionation at the air intake are relevant for high precision measurements of atmospheric O2.

  4. Study and development of an airborne instrument for collecting aerosols and for measuring radon 222 by its active deposition

    International Nuclear Information System (INIS)

    The study and development of an airborne instrument designed to collect aerosols and measure radon 222 is detailed in this thesis. Having discussed the context of radon and introduced the methods of the measurement of radon 222 by its natural active deposition, the measurement of aerosols with the Sextant Avionique/LSCE dynamic iso-kinetic probe is quantified. These estimations of the efficiency of the probe were obtained during iso-axial simulations of the flow around the probe at different sub-sonic speeds, then by the calculation of trajectories of particles at the entrance to the probe for several debit coefficients. The effect of the attack angle is discussed along with the iso-kinetic criteria of pressure necessary for the functioning of this probe. To conclude this theoretical study, the author has estimated the deposits during aerosol transport in pipes. The instrument once constructed, (dubbed A VIRAD), is then itself presented, along with the technological aspects adopted for its use. The instrument was validated during an experimental aerial study STAAARTE 99. The measures obtained during these flights are presented in the conclusions. (author)

  5. A model to explain simultaneously the {sup 222}Rn and {sup 220}Rn emanation from thin electrodeposited sources

    Energy Technology Data Exchange (ETDEWEB)

    Vargas, M.J.M. Jurado. E-mail: mjv@unex.es

    2000-06-11

    In thin radioactive sources, loss of radon by emanation is a very common phenomenon, especially in sources made by electrodeposition. A quantification of this effect in radium sources can be easily developed by using a simple model that assumes a radon diffusion term in the ingrowth equations. By measuring the corresponding Rn/Ra activity ratio, a constant diffusion factor can be determined which represents the Rn emanation from the whole source. However, this simple model cannot explain simultaneously the {sup 222}Rn and {sup 220}Rn diffusion produced in a thin source, because it gives diffusion factors that are different by many orders of magnitude for these two isotopes, while these values must be fairly close. In this paper, a new model of diffusion is proposed, which includes a linear dependence of the diffusion factor on the depth of Rn nuclides in the source. This new model has been applied to radium electrodeposited sources and allows us to explain satisfactorily both the {sup 220}Rn/{sup 224}Ra and {sup 222}Rn/{sup 226}Ra activity ratios observed in thin sources.

  6. An automatic static chamber for continuous {sup 220}Rn and {sup 222}Rn flux measurements from soil

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, B.E. E-mail: lehmann@climate.unibe.ch; Ihly, B.; Salzmann, S.; Onen, F.; Simon, E

    2004-02-01

    A closed-circuit analytical system for the (quasi)-continuous measurement f radon fluxes from soil consisting of a static accumulation chamber and two radon detectors operated in series is described. The first detector measures he ({sup 220}Rn+{sup 222}Rn) activity, the second one the remaining {sup 222}Rn activity after the {sup 220}Rn atoms (half-life 56 s) have decayed when the air asses a delay volume between the two detectors. A step-motor driven cover loses the chamber at the beginning of a flux measurement interval of e.g. 3 . In between measurements the chamber remains open to maintain soil and vegetation inside the chamber as closely as possible to the conditions outside. A mathematical description of the temporal evolution of Rn activities in the analytical system is presented from which procedures are derived to calculate Rn fluxes (Bq m{sup -2} s{sup -1}) from the measured activities n the two detectors. Examples from field tests illustrate the performance of he experimental set-up and possible complications due to technical and/or environmental difficulties.

  7. The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice.

    Directory of Open Access Journals (Sweden)

    Neri Mercatelli

    Full Text Available BACKGROUND: MiR-221 and miR-222 are two highly homologous microRNAs whose upregulation has been recently described in several types of human tumors, for some of which their oncogenic role was explained by the discovery of their target p27, a key cell cycle regulator. We previously showed this regulatory relationship in prostate carcinoma cell lines in vitro, underlying the role of miR-221/222 as inducers of proliferation and tumorigenicity. METHODOLOGY/PRINCIPAL FINDINGS: Here we describe a number of in vivo approaches confirming our previous data. The ectopic overexpression of miR-221 is able, per se, to confer a high growth advantage to LNCaP-derived tumors in SCID mice. Consistently, the anti-miR-221/222 antagomir treatment of established subcutaneous tumors derived from the highly aggressive PC3 cell line, naturally expressing high levels of miR-221/222, reduces tumor growth by increasing intratumoral p27 amount; this effect is long lasting, as it is detectable as long as 25 days after the treatment. Furthermore, we provide evidence in favour of a clinical relevance of the role of miR-221/222 in prostate carcinoma, by showing their general upregulation in patient-derived primary cell lines, where we find a significant inverse correlation with p27 expression. CONCLUSIONS/SIGNIFICANCE: These findings suggest that modulating miR-221/222 levels may have a therapeutic potential in prostate carcinoma.

  8. Matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via Akt and ERK/miR222/ETS-1 pathways in hepatic stellate cells.

    Science.gov (United States)

    Liu, Tianhui; Wang, Ping; Cong, Min; Zhang, Dong; Liu, Lin; Li, Hongyi; Zhai, Qingling; Li, Zhuo; Jia, Jidong; You, Hong

    2016-08-01

    Matrix metalloproteinase-1 (MMP-1) plays an important role in fibrolysis by degrading excessively deposited collagen I and III. We previously demonstrated that diethyldithiocarbamate (DDC) up-regulates MMP-1 in hepatic stellate cells via the ERK1/2 and Akt signalling pathways. In the current study, we attempted to further explore the molecular mechanisms involved in the regulation of MMP-1. We treated a co-cultured system that included hepatocytes (C3A) and hepatic stellate cells (LX-2) with DDC. The data revealed that the transcriptional factor ETS-1, which is an important regulator of MMP-1, was up-regulated in LX-2 cells following DDC treatment. Furthermore, the up-regulation of MMP-1 by DDC has been abrogated through employing si-ETS-1 to block expression of ETS-1. We found that DDC significantly inhibited the expression of miR-222 in LX-2 cells. We transfected miR-222 mimic into LX-2 cells and then co-cultured the cells with C3A. The up-regulation of ETS-1 and MMP-1 in LX-2 cells treated with DDC were inhibited after miR-222 mimic transfection. These data indicate that DDC up-regulated MMP-1 in LX-2 cells through the miR-222/ETS-1 pathway. Finally, we treated the co-cultured system with an Akt inhibitor (T3830) and an ERK1/2 inhibitor (U0126). Both T3830 and U0126 blocked the suppression of miR-222 by DDC in LX-2. Collectively, these data indicate that DDC up-regulated MMP-1 in LX-2 cells through the Akt and ERK/miR-222/ETS-1 pathways. Our study provides experimental data that will aid the control of the process of fibrolysis in liver fibrosis prevention and treatment.

  9. Matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via Akt and ERK/miR222/ETS-1 pathways in hepatic stellate cells.

    Science.gov (United States)

    Liu, Tianhui; Wang, Ping; Cong, Min; Zhang, Dong; Liu, Lin; Li, Hongyi; Zhai, Qingling; Li, Zhuo; Jia, Jidong; You, Hong

    2016-08-01

    Matrix metalloproteinase-1 (MMP-1) plays an important role in fibrolysis by degrading excessively deposited collagen I and III. We previously demonstrated that diethyldithiocarbamate (DDC) up-regulates MMP-1 in hepatic stellate cells via the ERK1/2 and Akt signalling pathways. In the current study, we attempted to further explore the molecular mechanisms involved in the regulation of MMP-1. We treated a co-cultured system that included hepatocytes (C3A) and hepatic stellate cells (LX-2) with DDC. The data revealed that the transcriptional factor ETS-1, which is an important regulator of MMP-1, was up-regulated in LX-2 cells following DDC treatment. Furthermore, the up-regulation of MMP-1 by DDC has been abrogated through employing si-ETS-1 to block expression of ETS-1. We found that DDC significantly inhibited the expression of miR-222 in LX-2 cells. We transfected miR-222 mimic into LX-2 cells and then co-cultured the cells with C3A. The up-regulation of ETS-1 and MMP-1 in LX-2 cells treated with DDC were inhibited after miR-222 mimic transfection. These data indicate that DDC up-regulated MMP-1 in LX-2 cells through the miR-222/ETS-1 pathway. Finally, we treated the co-cultured system with an Akt inhibitor (T3830) and an ERK1/2 inhibitor (U0126). Both T3830 and U0126 blocked the suppression of miR-222 by DDC in LX-2. Collectively, these data indicate that DDC up-regulated MMP-1 in LX-2 cells through the Akt and ERK/miR-222/ETS-1 pathways. Our study provides experimental data that will aid the control of the process of fibrolysis in liver fibrosis prevention and treatment. PMID:27412967

  10. Physical Parameters Affecting the Emanation of RADON-222 from Coal Ash.

    Science.gov (United States)

    Barton, Terence Patrick

    The Rn-222 emanation coefficients for coal ash and parameters which affected them were measured. Samples of ash from both stoker fired and pulverized coal fired boilers were obtained. The stoker ash samples were mechanically separated into size fractions. The pulverized samples were too fine for mechanical sizing and were categorized qualitatively according to origin. Bulk density of the stoker fractions was measured and ranged from .488 to .944 g-cm('-3), increasing as a function of decreasing particle size. Bulk density of the pulverized ash ranged from 1.254 to 1.520 g-cm('-3). Specific gravity of the stoker fractions ranged from 2.017 to 2.390 g-cm('-3), also increasing as a function of decreasing particle size. Specific gravity of the pulverized ash ranged from 2.357 to 2.588 g-cm(' -3). Ra-226 content of the samples was determined by gamma spectrometric analysis of the 352-KeV gamma of Pb -214 and the 609-KeV gamma of Bi-214 from sealed samples of ash. Ra-226 concentrations in the stoker fractions ranged from 11.82 to 16.77 dpm-g('-1), increasing as a function of decreasing particle size. Ra-226 concentrations in the pulverized ash ranged from 6.44 to 7.59 dpm-g(' -1). Scintillation cells were constructed out of commonly available materials and a commercial preparation of ZnS(Ag) scintillator. Emanation chambers which allowed for moderately large sample masses were constructed. The procedure used to measure emanation coefficients was shown to be insensitive to ingrowth time at greater than 3 days ingrowth and relatively insensitive to variations in sample porosity. Emanation coefficients of the stoker fractions were measured at moisture contents of 0, 1.0, 10, 20, and 40 percent by weight. Within each size fraction the emanation coefficient increased as a function of moisture content, ranging from 9.58 x 10('-4) to 4.13 x 10('-2) between 0 and 20 percent moisture, respectively. Emanation coefficients also increased as a function of decreasing particle size

  11. A complexity measure based method for studying the dependence of 222Rn concentration time series on indoor air temperature and humidity

    CERN Document Server

    Mihailovic, Dragutin T; Krmar, Miodrag; Arsenić, Ilija

    2013-01-01

    We have suggested a complexity measure based method for studying the dependence of measured 222Rn concentration time series on indoor air temperature and humidity. This method is based on the Kolmogorov complexity (KL). We have introduced (i) the sequence of the KL, (ii) the Kolmogorov complexity highest value in the sequence (KLM) and (iii) the KL of the product of time series. The noticed loss of the KLM complexity of 222Rn concentration time series can be attributed to the indoor air humidity that keeps the radon daughters in air.

  12. Compound heterozygosity with a novel S222N GALT mutation leads to atypical galactosemia with loss of GALT activity in erythrocytes but little evidence of clinical disease

    Directory of Open Access Journals (Sweden)

    Benjamin Cocanougher

    2015-03-01

    Full Text Available Galactosemia is an inborn error of galactose metabolism caused by mutations in the GALT gene. Though early detection and galactose restriction prevent severe liver disease, affected individuals have persistently elevated biomarkers and often neuro-developmental symptoms. We present a teenage compound heterozygote for a known pathogenic mutation (H132Q and a novel variant of unknown significance (S222N, with nearly absent erythrocyte GALT enzyme activity but normal biomarkers and only mild anxiety despite diet non-adherence. This case is similar to a previously reported S135L mutation. In this report we investigate the novel S222N variant and critically evaluate a clinically puzzling case.

  13. Biochemical and computational analyses of two phenotypically related GALT mutations (S222N and S135L) that lead to atypical galactosemia

    OpenAIRE

    Benjamin Cocanougher; Umut Aypar; Amber McDonald; Linda Hasadsri; Bennett, Michael J; Edward Highsmith, W.; Kristin D׳Aco

    2015-01-01

    Galactosemia is a metabolic disorder caused by mutations in the GALT gene [1,2]. We encountered a patient heterozygous for a known pathogenic H132Q mutation and a novel S222N variant of unknown significance [3]. Reminiscent of patients with the S135L mutation, our patient had loss of GALT enzyme activity in erythrocytes but a very mild clinical phenotype [3–8]. We performed splicing experiments and computational structural analyses to investigate the role of the novel S222N variant. Alamut so...

  14. Modular strategy for the synthesis of functionalized aryl-fused azabicyclo[2.2.2]octanes via sequential Cu/Pd/Ru catalysis.

    Science.gov (United States)

    McCormick, Lucas F; Malinakova, Helena C

    2013-09-01

    Aryl-fused 2-azabicyclo[2.2.2]octanes were prepared by a novel sequence of Cu-catalyzed three-component coupling of diversely substituted N-benzyl o-bromoaryl imines with methacryloyl chloride and vinyltributyl stannane followed by Pd-catalyzed Heck annulation. Subsequent diversification of the aryl-fused 2-azabicyclo[2.2.2]octane core was achieved by attaching a flexible linker and a potential second pharmacophore via Ru-catalyzed cross-metathesis and a nucleophilic substitution.

  15. Regulation of the p27Kip1 tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation

    OpenAIRE

    le Sage, Carlos; Nagel, Remco; Egan, David A.; Schrier, Mariette; Mesman, Elly; Mangiola, Annunziato; Anile, Corrado; Maira, Giulio; Mercatelli, Neri; Ciafrè, Silvia Anna; Farace, Maria Giulia; Agami, Reuven

    2007-01-01

    MicroRNAs (miRNAs) are potent post-transcriptional regulators of protein coding genes. Patterns of misexpression of miRNAs in cancer suggest key functions of miRNAs in tumorigenesis. However, current bioinformatics tools do not entirely support the identification and characterization of the mode of action of such miRNAs. Here, we used a novel functional genetic approach and identified miR-221 and miR-222 (miR-221&222) as potent regulators of p27Kip1, a cell cycle inhibitor and tumor suppresso...

  16. 222例职业性慢性苯中毒患者医院感染情况调查%Investigation of nosocomial infection among 222 cases of occupational chronic benzene poisoning

    Institute of Scientific and Technical Information of China (English)

    王建元; 刘健; 盛秋洁

    2015-01-01

    目的:探讨职业性慢性苯中毒患者医院感染的特征,为制定医院感染防护措施提供依据。方法选取2006年7月-2014年6月222例职业性慢性苯中毒患者的临床资料进行回顾性分析。结果222例职业性慢性苯中毒患者发生医院感染63例,感染率为28.38%;感染例次数为87例次,例次感染率为39.19%。呼吸道感染36例(41.38%)位居首位。病原菌主要为肺炎支原体与肺炎克雷伯菌,分别占40.90%和18.18%。中、重度中毒患者感染率分别为43.75%和48.00%。随着住院时间的延长医院感染率逐渐上升,住院时间3个月以内患者医院感染率为6.90%,住院时间12个月以上患者医院感染率为81.82%。对医院感染与住院时间进行 Pearson 相关性分析,r =0.439,P <0.01,说明两者呈正相关。结论慢性苯中毒为职业病患者中发生医院感染的高危人群,以呼吸道感染为主;住院时间愈长,感染风险愈大。护理过程中进行有效地护理干预可降低医院感染率。%Objective To investigate the characteristics of nosocomial infection among patients with occupational chronic benzene poisoning,in order to provide references for formulating related preventive measures.Method An retrospective investigation was carried out on the clinical data of 222 patients with occupational chronic benzene poisoning in our hospital from July 2006 to June 2014.Results Among the 222 patients, 63 of them had nosocomial infection, with an infection rate of 28.38%.The case number of infection was 87,with a case-time infection rate of 39.1 9%. The respiratory tract infection ranked first at 41.38% (36/87 ), with mycoplasma pneumoniae (40.90%)and klebsiella pneumoniae (18.18%)as pathogenic bacteria respectively. Among all the patients,43.75% suffered from medium-degree poisoning,while 48% were of severe poisoning.The rate of nosocomial infection increased gradually with the increase of stay in hospital. Among patients hospitalized for

  17. Estimated doses related to {sup 222}Rn concentration in bunker for radiotherapy and storage of radioisotopes; Dosis estimada por concentraciones de {sup 222}Rn en bunker de radioterapia y de almacenamiento de isotopos radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Mestre, Freddy; Carrizales-Silva, Lila, E-mail: freddymest@gmail.com, E-mail: lcarriza@ivic.gob.ve [Instituto Venezolano de lnvestigaciones Cientificas, Caracas (Venezuela, Bolivarian Republic of); Sajo-Bohus, Laszlo, E-mail: sajobohus@gmail.com [Universidad Simon Bolivar, Caracas (Venezuela, Bolivarian Republic of). Laboratorio de Fisica Nuclear; Diaz, Cruz, E-mail: cruzediaZ@gmail.com [Universidad Pedagogica Experimental Libertador, Barquisimeto (Venezuela, Bolivarian Republic of). Instituto Pedagogico

    2013-07-01

    It was done a survey in radiotherapy services underground hospitals and clinics of Venezuela and Paraguay in order to estimate the concentrations of radon and its possible consequences on worker occupational exposure. Passive dosimeters were used to assess nuclear traces (NTD type CR-39 Registered-Sign ). The concentration of {sup 222}Rn is determined based on the density of traces using the calibration coefficient of 1 tr/cm{sup 2} equivalent to 0,434 Bqm{sup -3} per month of exposure. Assuming the most likely environmental conditions and the dose conversion factor equal to 9.0 x 10{sup -6} mSv h {sup -1} by Bqm{sup -3}, it was determined the average values and estimated the possible risks to health that are on average 3.0 mSva{sup -1} and 150 micro risk cancer.

  18. Uranium, radon-222 and polonium-210 in drinking waters from metropolitan area of Recife, PE, Brazil; Uranio, radonio-222 e polonio-210 em aguas de abastecimento publico da regiao metropolitana do Recife

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Cleomacio Miguel da

    2000-04-01

    There is only scarce information on the presence of radionuclides in water for public consumption in Brazil. A recently issued federal regulation requires that waters from public supplies be screened to determine their content of alpha and beta emitters. In order to comply with this requirement the present work was carried out with the purpose of determining the concentration of natural uranium, {sup 222} Rn and {sup 210} Po in water supplies in the metropolitan region of Recife, Brazil. The analyses were performed in 17 points of supply of superficial water and 94 points of groundwater supply. The concentrations of uranium were determined by the fluorimetric method, whereas the liquid scintillation method was used to determine the concentration of {sup 222} Rn. Polonium-210, on the other hand, was determined by alpha spectrometry, following its spontaneous deposition on copper disks. The water analyzer presented uranium concentrations varying from 35.3 to 1146.5 mBq/L for superficial resources and from 20.2 to 919.15 mBq/L for underground sources. The concentration of uranium in superficial water showed significant correlation with some parameters such as conductivity, alkalinity and total hardness, as well as, with the concentrations of Ca, Mg, Cl, K, SO{sub 4} and Mn. No correlation, however, was shown with the concentrations of Fe, NO{sub 2} and NO{sub 3}. The concentrations of {sup 222} Rn varied from 5.3 to 83.7 Bq/L in the groundwater analyzer. Radon concentration was not measured in superficial water due to the high emanation rate of radon in open air conditions. As far as {sup 210} Po is concerned, the analyses showed concentrations ranging from <22 mBq/L (the lowest limit of detection) to 57.4 mBq/L for superficial water and from <22 to 813 mBq/L for ground water samples. The concentrations of {sup 210} Po did not show and correlation with physico-chemical parameters. The average concentrations of uranium and {sup 210} Po in superficial water were of 44

  19. Production of actinium-225 for alpha particle mediated radioimmunotherapy.

    Science.gov (United States)

    Boll, Rose A; Malkemus, Dairin; Mirzadeh, Saed

    2005-05-01

    The initial clinical trials for treatment of acute myeloid leukemia have demonstrated the effectiveness of the alpha emitter (213)Bi in killing cancer cells. Bismuth-213 is obtained from a radionuclide generator system from decay of 10-days (225)Ac parent. Recent pre-clinical studies have also shown the potential application of both (213)Bi, and the (225)Ac parent radionuclide in a variety of cancer systems and targeted radiotherapy. This paper describes our five years of experience in production of (225)Ac in partial support of the on-going clinical trials. A four-step chemical process, consisting of both anion and cation exchange chromatography, is utilized for routine separation of carrier-free (225)Ac from a mixture of (228)Th, (229)Th and (232)Th. The separation of Ra and Ac from Th is achieved using the marcoporous anion exchange resin MP1 in 8M HNO(3) media. Two sequential MP1/NO(3) columns provide a separation factor of approximately 10(6) for Ra and Ac from Th. The separation of Ac from Ra is accomplished on a low cross-linking cation exchange resin AG50-X4 using 1.2M HNO(3) as eluant. Two sequential AG50/NO(3) columns provide a separation factor of approximately 10(2) for Ac from Ra. A 60-day processing schedule has been adopted in order to reduce the processing cost and to provide the highest levels of (225)Ac possible. Over an 8-week campaign, a total of approximately 100 mCi of (225)Ac (approximately 80% of the theoretical yield) is shipped in 5-6 batches, with the first batch typically consisting of approximately 50 mCi. After the initial separation and purification of Ac, the Ra pool is re-processed on a bi-weekly schedule or as needed to provide smaller batches of (225)Ac. The averaged radioisotopic purity of the (225)Ac was 99.6 +/- 0.7% with a (225)Ra content of < or =0.6%, and an average (229)Th content of (4(-4)(+5)) x 10(-5)%.

  20. Possibility of rapidly reporting 226Ra activity in 226Ra-222Rn samples with unknown equilibrium factor by γ spectrometer

    Institute of Scientific and Technical Information of China (English)

    SU Qiong; ZHENG Rui; CHEN Yong; CHENG Jian-Ping

    2004-01-01

    This paper reports the observed changes for equilibrium factors between 226Ra and 222Rn with sealing time of the samples. The samples include soil, raw coal, mineral water, cement, rock, etc. Especially the conceptions of "pre-equilibrium time" and "pre-equilibrium factor" have been put forward and methods of measuring and processing data have been given which can be used for rapidly reporting activity of 226Ra in samples with unknown equilibrium factor. It is definitely concluded that, using methods given in the paper, a test report will be completed in 3~7days, instead of one month, after receiving the sample whose activity is not lower than LLD of the spectrometer.

  1. Crystal structure of bis(1,4-diazabicyclo[2.2.2]octan-1-ium thiosulfate dihydrate

    Directory of Open Access Journals (Sweden)

    Gorgui Awa Seck

    2016-03-01

    Full Text Available The crystal structure of the hydrated title salt, 2C6H13N2+·S2O32−·2H2O, contains a centrosymmetric cyclic motif of eight hydrogen-bonded molecular subunits. Two DABCOH+ cations (DABCO = 1,4-diazabicyclo[2.2.2]octane are linked to two water molecules and two thiosulfate anions via O—H...N and O—H...O hydrogen bonds, respectively. Two other water molecules close the cyclic motif through O—H...O contacts to the first two water molecules and to the two thiosulfate anions. A second pair of DABCOH+ cations is N—H...O hydrogen bonded to the two anions and is pendant to the ring. Adjacent cyclic motifs are bridged into a block-like arrangement extending along [100] through O—H...O interactions involving the second pair of water molecules and neighbouring thiosulfate anions.

  2. Kinetics of the Exothermic Decomposition Reaction of N-Methyl-N-nitro-2,2,2- trinitroethanamine

    Institute of Scientific and Technical Information of China (English)

    陈三平; 胡荣祖; 宋纪蓉; 杨得琐; 高胜利; 赵宏安; 史启祯

    2003-01-01

    The thermal behavior and kinetic parameters of the exothermic decomposition reaction of N-methyl-N-nitro-2,2,2-trinitroethanamine in a temperature-programmed mode have been investigated by means of differential scanning calorimetry (DSC).The kinetic equation of the exothermic decomposition process of the compound is proposed. The values of the apparent activation energy (Ea), pre-exponential factor (A), entropy of activation (ΔS≠ ), enthalpy of activation (ΔH≠ ), and free energy of activation (ΔG≠ ) of this reaction and the critical temperature of thermal explosion of the compound are reported. Information is obtained on the mechanism of the initial stage of the thermal decomposition of the compound.

  3. Thermal Behavior of N,N'-Bis[N-(2,2,2-trinitroethyl)-N-nitro]ethylenediamine

    Institute of Scientific and Technical Information of China (English)

    CHEN,San-Ping(陈三平); HU,Rong-Zu(胡荣祖); SONG,Ji-Rong(宋纪蓉); YANG,De-Suo(杨得琐); GAO,Sheng-Li(高胜利); SHI,Qi-Zhen(史启祯)

    2004-01-01

    The thermal behavior and kinetic parameters of the exothermic decomposition reaction of N,N'-bis[N-(2,2,2-trinitroethyl)-N-nitro]ethylenediamine in a temperature-programmed mode have been investigated by means of differential scanning calorimetry (DSC). The results show that kinetic model function in differential form, apparent activation energy Ea and pre-exponential factor A of this reaction are 3(1-α)2/3, 203.67 kJ·mol-1 and 1020.61 s-1, respectively. The critical temperature of thermal explosion of the compound is 182.2 ℃. The values of △S≠, △H≠ and △G≠ of this reaction are 143.3 J·mol-1·K-1, 199.5 kJ·mol-1 and 135.5 kJ·mol-1, respectively.

  4. Characterization of LR-115 Type 2 Detectors for Monitoring Indoor Radon 222: Determination of the Calibration Factor

    Directory of Open Access Journals (Sweden)

    P. Pereyra

    2016-08-01

    Full Text Available The city of Lima, capital of Peru, has about 11 million inhabitants. Lima has no records about the indoor Radon 222 concentration levels in dwellings. Hereby, we are planning to register the indoor radon concentrations in Lima and in other cities of Peru in the next three years. First, we will determine the calibration factor for the detectors which will be used in our measurements. For this purpose, Solid State Nuclear Tracks Detectors of nitrocellulose nitrate (LR-115 type 2 were used.The calibration process using a Radium 226 source was described to obtain the calibration factor. Linear response in tracks number was found in relation with irradiation time and its stability after time at the calibration chamber.

  5. Role of gga-miR-221 and gga-miR-222 during Tumour Formation in Chickens Infected by Subgroup J Avian Leukosis Virus

    Directory of Open Access Journals (Sweden)

    Zhenkai Dai

    2015-12-01

    Full Text Available Subgroup J avian leukosis virus (ALV-J causes a neoplastic disease in infected chickens. Differential expression patterns of microRNAs (miRNAs are closely related to the formation and growth of tumors. (1 Background: This study was undertaken to understand how miRNAs might be related to tumor growth during ALV-J infection. We chose to characterize the effects of miR-221 and miR-222 on cell proliferation, migration, and apoptosis based on previous microarray data. (2 Methods: In vivo, the expression levels of miR-221 and miR-222 were significantly increased in the liver of ALV-J infected chickens (p < 0.01. Over-expression of gga-miR-221 and gga-miR-222 promoted the proliferation, migration, and growth of DF-1 cells, and decreased the expression of BCL-2 modifying factor (BMF making cells more resistant to apoptosis. (3 Results: Our results suggest that gga-miR-221 and gga-miR-222 may be tumour formation relevant gene in chicken that promote proliferation, migration, and growth of cancer cells, and inhibit apoptosis. BMF expression was significantly reduced in vivo 70 days after ALV-J infection. They may also play a pivotal role in tumorigenesis during ALV-J infection.

  6. Survey of 222Rn concentrations in the air of a tunnel located in Nagano City using the solid-state nuclear track detector method

    International Nuclear Information System (INIS)

    The survey of 222Rn concentration in the air of tunnels constructed during World War II has been performed using a solid-state nuclear track detector technique. For the practical application of this technique t the determination of 222Rn concentrations in air, some basic properties were experimentally examined on the cellulose nitrate film, Kodak LR 115 type II. The calibration coefficient of the cellulose nitrate film used is determined from a correlation between the 222Rn concentration in air and the observed number of perforated etched tracks for widespread radon concentrations. The slope of the linear relationship observed yields a calibration coefficient of (0.00209 ± 0.00018) tracks cm-2 (Bq m-3 h)-1. From the survey of 222Rn concentration in the air of tunnels, the concentration of several thousand Bq m-3 was observed at the inner most area of the tunnel, and the seasonal variation was clearly observed. The exponential distribution of radon concentration as a function of distance from the openings of the tunnel suggests that the radon concentration in the tunnel is basically governed by diffusion and mixing of radon gas with air

  7. Inhalation exposures due to radon and thoron ((222)Rn and (220)Rn): Do they differ in high and normal background radiation areas in India?

    Science.gov (United States)

    Mishra, Rosaline; Sapra, B K; Prajith, R; Rout, R P; Jalaluddin, S; Mayya, Y S

    2015-09-01

    In India, High Background Radiation Areas (HBRAs) due to enhanced levels of naturally occurring radionuclides in soil (thorium and, to a lesser extent, uranium), are located along some parts of the coastal tracts viz. the coastal belt of Kerala, Tamilnadu and Odisha. It is conjectured that these deposits will result in higher emissions of radon isotopes ((222)Rn and (220)Rn) and their daughter products as compared to Normal Background Radiation Areas (NBRAs). While the annual external dose rates contributed by gamma radiations in these areas are about 5-10 times higher, the extent of increase in the inhalation dose rates attributable to (222)Rn and (220)Rn and their decay products is not well quantified. Towards this, systematic indoor surveys were conducted wherein simultaneous measurements of time integrated (222)Rn and (220)Rn gas and their decay product concentrations was carried out in around 800 houses in the HBRAs of Kerala and Odisha to estimate the inhalation doses. All gas measurements were carried out using pin-hole cup dosimeters while the progeny measurements were with samplers and systems based on the Direct radon/thoron Progeny sensors (DRPS/DTPS). To corroborate these passive measurements of decay products concentrations, active sampling was also carried out in a few houses. The results of the surveys provide a strong evidence to conclude that the inhalation doses due to (222)Rn and (220)Rn gas and their decay products in these HBRAs are in the same range as observed in the NBRAs in India. PMID:26065929

  8. NF M 60-771. Nuclear energy - Radioactivity measurements in the environment - Air - Radon 222 in buildings: methodologies applied to tracking and complementary investigations

    International Nuclear Information System (INIS)

    This French standard (NF M60-771) from February 2003, describes the procedure for the dosimetry of radon in buildings. The procedure concerns the early tracking and the complementary measurements of 222Rn concentration in the ambient air. (J.S.)

  9. 20 CFR 30.222 - How does a claimant establish that the employee has been diagnosed with chronic silicosis or has...

    Science.gov (United States)

    2010-04-01

    ... employee has been diagnosed with chronic silicosis or has sustained a consequential injury, illness... § 30.222 How does a claimant establish that the employee has been diagnosed with chronic silicosis or has sustained a consequential injury, illness, impairment or disease? (a) A written diagnosis of...

  10. Rhodium-catalyzed selective[2+2+2]cyclizations of 1,6-diynes with monoynes leading to isoindolines and isobenzofurans

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    A highly efficient and selective[2+2+2]cyclization of diynes and monoalkynes was catalyzed by rhodium under room temperature in water/THF mixed solvent,affording isoindolines and isobenzofurans in good to excellent yields.The center atoms (N,O) in the diynes showed a significant effect for the cyclization.

  11. Assessment of natural radium isotopes and 222Rn in water samples from Cananeia-Iguape estuarine complex, Sao Paulo, Brazil

    International Nuclear Information System (INIS)

    Radium isotopes and radon are among the most important natural radionuclides in the environment from both radioprotection and geo-hydrological points of view. These radionuclides are a powerful tool for studying coastal processes and have been used intensively as tracers of groundwater sources that discharge into the ocean. In this paper, naturally occurring radium isotopes and 222Rn were determined to trace water exchange and SGD in Cananeia-Iguape estuarine complex, a shallow coastal plain estuary in southern Sao Paulo area. The research work was carried out during the first semester of 2009 and covered stations located both in Cananeia and Iguape outlets, as well as samples collected in Ribeira of Iguape River and groundwater. Activity concentrations of 226Ra in estuarine waters from Cananeia outlet varied from 2.9 mBq L-1 to 4.7 mBq L-1, while 228Ra concentrations ranged from 22 mBq L-1 to 45 mBq L-1. In Iguape outlet, activities of 226Ra ranged from 1.6 mBq L-1 to 6.6 mBq L-1; 228Ra varied from 13 mBq L-1 to 20 mBq L-1. Activities of Ra were slightly higher in samples collected at 5 m depth than at the surface water level. Groundwater activity concentrations of 226Ra ranged from 0.63 mBq L-1 to 12 mBq L-1 and for 228Ra from 18 mBq L-1 to 39 mBq L-1. In groundwater, the 228Ra/226Ra activity ratios varied from 3.3 to 31.7. 222Rn activities in groundwater up to 747 Bq L-1 were observed. Increased nitrate contents were observed in groundwater samples collected in Cananeia and Comprida Island. (author)

  12. Recurrent 70.8 Mb 4q22.2q32.3 duplication due to ovarian germinal mosaicism.

    Science.gov (United States)

    Tosca, Lucie; Brisset, Sophie; Petit, François M; Lecerf, Laure; Rousseau, Ghislaine; Bas, Cécile; Laroudie, Mireille; Maurin, Marie-Laure; Tapia, Sylvie; Picone, Olivier; Prevot, Sophie; Goossens, Michel; Labrune, Philippe; Tachdjian, Gérard

    2010-08-01

    A mosaicism is defined by the presence of two or more populations of cells with different genotypes in one individual. Chromosomal germinal mosaicism occurs in germ cells before the onset of meiosis. Previously, few studies have described germinal mosaicism. In this study, we report on two siblings who carried identical pure and direct interstitial 4q22.2q32.3 duplication. Procedure investigations included complete clinical description, conventional cytogenetic analysis, fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH) array experiments and microsatellite study searching for parental origin of the duplication. Microarray CGH and further FISH experiments with BAC clones showed the same 70.8 Mb direct duplication, dup(4)(q22.2q32.3). Molecular studies of the 4q duplication were consistent with maternal origin associated with mitotic or meiotic rearrangements. This structural chromosomal aberration was associated in both cases with increased nuchal translucency, growth retardation and dysmorphy. Cardiopathy and lung malformations were only evident in the first case. These clinical manifestations are similar to those previously reported in previous studies involving pure 4q trisomy of the same region, except for thumb and renal abnormalities that were not obvious in the presented cases. The amplified region included genes involved in neurological development (NEUROG2, MAB21L2, PCDH10/18 and GRIA2). The recurrent 4q duplication in these siblings is consistent with a maternal ovarian germinal mosaicism. This is the first description of germinal mosaicism for a large chromosomal duplication and highlights that genetic counselling for apparently de novo chromosome aberration should be undertaken with care.

  13. Evaluation of 222Rn concentration of the internal and external environments of residences at Monte Alegre municipality, Para, Brazil

    International Nuclear Information System (INIS)

    The human being is constantly exposed to the natural radioactivity in the environment where he lives. This radioactivity comes mainly from materials present in the terrestrial crust that possess in their constitution chemical elements belonging to the radioactive families of uranium and thorium. The use of such materials for the construction of houses constitutes an important exposure form to the natural radiation, above all to the radioactive gas 222Rn, that it is exhaled from them. The Brazilian soil is composed, among other, of minerals that contain appreciable concentrations of these elements. The inhabitants of Monte Alegre town in Para, located at 2 deg 00' 24,9 'S ; 54 deg 04 ' 13,5 W, used in the construction of their houses stones obtained from an area 20 km distant of Monte Alegre, denominated Ingles de Souza, located at 01 deg 56' 4 0,1 S; 54 deg 12 149,7 W, where a small residential village, denominated National Agricultural Colony of Para (CANP), is located. The objective of this work was to evaluate the indoor concentration of 222Rn in the residences of Monte Alegre and CANP. Determinations of the 238U and 226Ra concentrations, measurements of the radon flux in samples of stones and soils of the two regions, as well as measurements to the gamma dose close of the soil and inside the residences, were also carried out. The average results of the radon concentration in the air of the investigated residences did not exceed the limits of 200 Bq. m3 (action level) and 600 Bq. m3 (intervention level) recommended by the International Commission on Radiological Protection (ICRP). The concentrations of natural radionuclides and the radon flux determined at the village showed values 17 times higher than those found at the urban area of Monte Alegre, while the average indoor gamma dose rate in the village residences was 0.86 mSv/a. (author)

  14. Studies on 226Ra and 222Rn concentration in drinking water of Mandya region, Karnataka State, India

    Directory of Open Access Journals (Sweden)

    B.C. Shivakumara

    2014-10-01

    Full Text Available Radium is naturally occurring radioactive element in the earth's crust. It is chemically similar to calcium and absorbed from soil by plants, passed up the food chain to humans. The occurrence and the distribution of radioactivity in water depend on the local geological characteristics of the source, soil, rock and other factors that control the occurrence and distribution of radionuclides in ground water and the hydro geological condition and the geochemistry of radionuclides. Activities of the naturally occurring radionuclides 226Ra and 222Rn were determined in natural ground water of the Mandya district, Karnataka State, India. The concentration of 222Rn in borewell water varies form 6.44 ± 0.20 to 44.83 ± 0.54 Bq l−1 with geometric mean 16.42 ± 0.31 Bq l−1. Higher radon concentrations were observed at Yettaganahalli and Mandya city. 226Ra concentration varies form 14.26 ± 0.32 to 81.06 ± 0.99 mBq l−1 with geometric mean 27.61 ± 0.43 mBq l−1. It is observed that the radon concentration is high in ground water around the granitic rock exposures and similarly observation of high values of radon is reported in sheared gneiss which covers major portion of the Mandya district to phyllites and schists. The total dose due to ingestion and inhalation varies from 26.31 to 178.53 μSv y−1 with a geometric mean of 65.94 μSv y−1, which is below the prescribed dose limit of 100 μSv y−1 by WHO.

  15. Development of an inventory/archive program for the retention, management, and disposition of tank characterization samples at the 222-S laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Seidel, C.M.

    1998-04-29

    The Hanford Tank Waste Remediation Systems (TWRS) Characterization Program is responsible for coordinating the sampling and analysis of the 177 large underground storage tanks at the Hanford site. The 222-S laboratory has been the primary laboratory for chemical analysis of this highly-radioactive material and has been accumulating these samples for many years. As part of the Fiscal Year 1998 laboratory work scope, the 222-S laboratory has performed a formal physical inventory of all tank characterization samples which are currently being stored. In addition, an updated inventory/archive program has been designed. This program defines sample storage, retention, consolidation, maintenance, and disposition activities which will ensure that the sample integrity is preserved to the greatest practical extent. In addition, the new program provides for continued availability of waste material in a form which will be useful for future bench-scale studies. Finally, when the samples have exceeded their useful lifetime, the program provides for sample disposition from,the laboratory in a controlled, safe and environmentally compliant manner. The 222-S laboratory maintains custody over samples of tank waste material which have been shipped to the laboratory for chemical analysis. The storage of these samples currently requires an entire hotcell, fully dedicated to sample archive storage, and is rapidly encroaching on additional hotcell space. As additional samples are received, they are beginning to limit the 222-S laboratory hotcell utility for other activities such as sample extrusion and subsampling. The 222-S laboratory tracks the number of sample containers and the mass of each sample through an internal database which has recently been verified and updated via a physical inventory.

  16. Development of an inventory/archive program for the retention, management, and disposition of tank characterization samples at the 222-S laboratory

    International Nuclear Information System (INIS)

    The Hanford Tank Waste Remediation Systems (TWRS) Characterization Program is responsible for coordinating the sampling and analysis of the 177 large underground storage tanks at the Hanford site. The 222-S laboratory has been the primary laboratory for chemical analysis of this highly-radioactive material and has been accumulating these samples for many years. As part of the Fiscal Year 1998 laboratory work scope, the 222-S laboratory has performed a formal physical inventory of all tank characterization samples which are currently being stored. In addition, an updated inventory/archive program has been designed. This program defines sample storage, retention, consolidation, maintenance, and disposition activities which will ensure that the sample integrity is preserved to the greatest practical extent. In addition, the new program provides for continued availability of waste material in a form which will be useful for future bench-scale studies. Finally, when the samples have exceeded their useful lifetime, the program provides for sample disposition from,the laboratory in a controlled, safe and environmentally compliant manner. The 222-S laboratory maintains custody over samples of tank waste material which have been shipped to the laboratory for chemical analysis. The storage of these samples currently requires an entire hotcell, fully dedicated to sample archive storage, and is rapidly encroaching on additional hotcell space. As additional samples are received, they are beginning to limit the 222-S laboratory hotcell utility for other activities such as sample extrusion and subsampling. The 222-S laboratory tracks the number of sample containers and the mass of each sample through an internal database which has recently been verified and updated via a physical inventory

  17. Value of combined detection of serum miR-21,miR-195 and miR-222 in the diagnosis of early breast cancer

    Institute of Scientific and Technical Information of China (English)

    Wen-Zhao Zhang; Ying Li; De-Xiang Wu

    2016-01-01

    Objective:To study level of miRNA in the serum of early breast carcinoma patients and to evaluate the clinical diagnostic value of combined detection of early breast carcinoma. Methods:A total of 54 cases of early breast carcinoma, 58 cases of benign breast diseases and 70 cases of healthy physical examination women were selected as the research subjects, to analysis serum miR-21, miR-195 and miR-222 levels by fluorescence quantitative PCR method and to analyze the diagnostic value of single and combined detection in early breast cancer by receiver operating characteristic curve. Results:The relative expression levels of miR-21, miR-222 and miR-195 in early breast carcinoma patients were significantly higher than those in benign breast disease and healthy controls;there was no significant difference in the relative expression of miR-21, miR-222 and miR-195 in the benign breast disease group and healthy control group;receiver operating characteristic curve analysis showed that AUC of miR-21, miR-195 and miR-222 in the diagnosis of early breast carcinoma were 0.805, 0.86 and 0.848 respectively, the sensitivity were 63.3%, 70.0%and 70.0%, and the specificity were 86.7%, 93.3%and 90.0%;AUC, sensitivity and specificity of the combined detection were 0.974, 93.3%and 96.7%respectively. Conclusion:miR-21, miR-195 and miR-222 levels in serum of patients with early breast carcinoma rise, the combined detection of the 3 indicators have a high diagnostic value for early breast carcinoma, and contribute to early breast carcinoma screening and diagnosis.

  18. Determination of Rn{sup 222} in samples of well water and domicile of the cities of Chihuahua and Aldama, Mexico; Determinacion de Rn{sup 222} en muestras de agua de pozos y domicilio de las ciudades de Chihuahua y Aldama, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Villalba, L.; Colmenero S, L.; Montero C, M.E. [Centro de Investigacion en Materiales Avanzados (CIMAV), Av. Miguel de Cervantes Saavedra 120, 31109 Chihuahua (Mexico)]. e-mail: lourdes.villalba@cimav. edu. mx

    2004-07-01

    The study of the content of dissolved Rn{sup 222} is presented in underground water and of domicile of the cities of Chihuahua and Aldama of the State of Chihuahua. The existence of the Rn{sup 222} in the underground waters comes from its constant production in the rocks of the terrestrial bark. It has been determined that the radon is a noble gas of more solubility in the water, this solubility induces high concentrations in underground water, as well as bigger risk to the health in the human body once ingested or inhaled. Of the 32 wells studied in the cities of Chihuahua and Aldama, the content of dissolved Rn{sup 222} in the water of 22 of them is bigger than 11 Bq/l and of 73 studied samples of water of domiciles 47 show bigger values that 11 Bq/l. These radon contents are attributable to the uraniferous rocks present in the aquifers. (Author)

  19. Evaluation of {sup 222}Rn concentration of the internal and external environments of residences at Monte Alegre municipality, Para, Brazil; Avaliacao da concentracao do {sup 222}Rn nos ambientes internos e externos de residencias do municipio de Monte Alegre, PA

    Energy Technology Data Exchange (ETDEWEB)

    Melo, Vicente de Paula

    1999-07-01

    The human being is constantly exposed to the natural radioactivity in the environment where he lives. This radioactivity comes mainly from materials present in the terrestrial crust that possess in their constitution chemical elements belonging to the radioactive families of uranium and thorium. The use of such materials for the construction of houses constitutes an important exposure form to the natural radiation, above all to the radioactive gas {sup 222}Rn, that it is exhaled from them. The Brazilian soil is composed, among other, of minerals that contain appreciable concentrations of these elements. The inhabitants of Monte Alegre town in Para, located at 2 deg 00' 24,9 'S ; 54 deg 04 ' 13,5 {sup W}, used in the construction of their houses stones obtained from an area 20 km distant of Monte Alegre, denominated Ingles de Souza, located at 01 deg 56' 4 0,1 S; 54 deg 12 149,7 W, where a small residential village, denominated National Agricultural Colony of Para (CANP), is located. The objective of this work was to evaluate the indoor concentration of {sup 222}Rn in the residences of Monte Alegre and CANP. Determinations of the {sup 238}U and {sup 226}Ra concentrations, measurements of the radon flux in samples of stones and soils of the two regions, as well as measurements to the gamma dose close of the soil and inside the residences, were also carried out. The average results of the radon concentration in the air of the investigated residences did not exceed the limits of 200 Bq. m{sup 3} (action level) and 600 Bq. m{sup 3} (intervention level) recommended by the International Commission on Radiological Protection (ICRP). The concentrations of natural radionuclides and the radon flux determined at the village showed values 17 times higher than those found at the urban area of Monte Alegre, while the average indoor gamma dose rate in the village residences was 0.86 mSv/a. (author)

  20. Differences of near-ground atmospheric Rn-222 concentration between urban and rural area with reference to microclimate diversity

    Science.gov (United States)

    Podstawczyńska, Agnieszka

    2016-02-01

    A unique 4-year dataset of hourly near-surface meteorological and atmospheric Radon-222 measurements made simultaneously at adjacent rural and urban sites in central Poland are presented and discussed. The annual, seasonal and diurnal variations of Rn-222 concentration were analysed. The magnitude of the urban heat island effect (UHI: difference in 2 m air temperature between the urban and rural regions) was found to be reasonably well correlated with traditional atmospheric stability indicators (i.e. wind speed and near-surface temperature gradient). To better quantify the influence of the UHI on the strength/depth of nocturnal mixing, the rural radon observations were used to classify the nocturnal mixing state regionally on a nightly basis, enabling a comparison between the rural and urban observations over four stability categories ranging from near-neutral to stable. Averaged over the entire dataset, near-neutral nocturnal conditions were characterised by 2 m wind speeds, U2m, of ˜1.3 m s-1 and 2-0.2 m temperature gradients, ΔT, of ˜0.5 °C in the rural region, compared to U2m = 1.15 m s-1 and ΔT = -0.24 °C in the urban region. By comparison, under regionally stable conditions U2m = 0.6 m s-1 and ΔT = 1.5-2.0 °C in the rural region and U2m = 0.8 m s-1 and ΔT = -0.25 °C in the urban region. Between near-neutral to stable conditions, the nocturnal UHI varied from ˜0.8 to 2.4 °C. The higher wind speeds under regionally stable conditions in the urban centre compared to the rural region (25 km distant) indicate that the slightly unstable conditions and UHI = 2.4 °C are sufficient to sustain a meso-scale circulation cell. The effect that the nocturnal urban heating has locally on the atmosphere's ability to dilute primary pollutants at night is indicated by the contrasting diurnal amplitude of radon concentration at each site under regionally stable conditions: ˜9 Bq m-3 in the rural region and ˜2 Bq m-3 in the urban region.

  1. Parameters of calibration of the measurement system of {sup 222} Rn based in LR-115; Parametros de calibracion del sistema de medicion de {sup 222} Rn basado en LR-115

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, M.L.; Mireles, F.; Quirino, L.; Davila, I.; Lugo, F.; Pinedo, J.L. [CREN-UAZ, 98068 Zacatecas (Mexico); Chavez, A. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: mluisagb@hotmail.com

    2003-07-01

    Since the SSNTD technique (Solid State Nuclear Track Detection) it was discovered it has been used as passive method for the detection of subnuclear particles in great variety of fields of the science. The use of the technique in measurements of {sup 222} Rn in air have already been established implying better methodologies in the exhibition to the environment until their engraving and reading processes. The SSNTD technique is since a method by comparison since the material it can be used a single time, therefore it requires of calibration in one controlled radon atmosphere, using gauged standards. The objective of this work is to show the calibration of the devices used as radon monitors based on SSNTD. The material used as SSNTD is LR-115 Il. The standardization of the parameters used in the exhibition to radon in air, engraving and reading process, its are based on the response of the LR-115 Il, the one arrangement of the device, engraving speed and mainly the calibration factor. They are considered two types of monitors: Open camera and Closed camera, the difference among the calibration factors of both cameras is the percentage of the descendants of radon in the open camera. The standardized parameters are operation voltage of the counting system; temperature, time and concentration of the engraving solution; and thickness. (Author)

  2. The radon 222 transport in soils. The case of the storage of residues coming from uranium ores processing; La migration du radon 222 dans un sol. Application aux stockages de residus issus du traitement des minerais d'uranium

    Energy Technology Data Exchange (ETDEWEB)

    Ferry, C

    2000-07-01

    Uranium Mill Tailings (UMT) contain comparatively large quantities of radium-226. This radionuclide yields, by radioactive decay, the radioactive gas radon-222. Tailing piles are routinely covered to reduce the radon release-rate into the atmosphere. In order to assess the long term environmental impact of a UMT repository, mechanisms governing radon exhalation at the soil surface must be deciphered and understood. A model of radon transport in the unsaturated zone is developed for this purpose: water- and air-flow in the porous material are determined, as well as radon transport by diffusion in the pore space and advection by the gas phase. The radon transport model in the unsaturated zone - TRACI (which stands, in French, for Radon Transport within the Unsaturated Layer) - calculates moisture contents in the soil, Darcy's velocities of the liquid and gas phases, radon concentrations in the gas phase and radon flux at the soil surface. TRACI's results are compared with observations carried out on a UMT and a cover layer. Input parameters are derived from the textural analysis of the material under study, whereas upper boundary conditions are given by meteorological data. If we consider measurement errors and uncertainties on the porous medium characterisation, model's results are generally in good agreement with observations, at least on the long run. Moreover, data analysis shows hat transient phenomena are understood as well, in most situations. (author)

  3. A two-dimensional cadmium(II) coordination polymer based on 1-cyanomethyl-4-aza-1-azoniabicyclo[2.2.2]octane and thiocyanate ligands.

    Science.gov (United States)

    Wang, Hui-Ting; Li, Qiang; Zhou, Lin

    2015-09-01

    A cadmium-thiocyanate complex, poly[(1-cyanomethyl-4-aza-1-azoniabicyclo[2.2.2]octane-κ(4)N)octakis-μ2-thiocyanato-κ(8)N:S;κ(8)S:N-tricadmium(II)], [Cd3(C8H14N3)2(NCS)8]n, was synthesized by the reaction of 1-cyanomethyl-4-aza-1-azoniabicyclo[2.2.2]octane chloride, cadmium nitrate tetrahydrate and potassium thiocyanide in aqueous solution. In the crystal structure, there are two independent types of Cd(II) cation (one on a centre of inversion and one in a general position) and both are in distorted octahedral coordination environments, coordinated by N and S atoms from different ligands. Neighbouring Cd(II) cations are linked together by thiocyanate bridges to form a two-dimensional network. Hydrogen-bonding interactions are involved in the formation of a three-dimensional supramolecular network. PMID:26322607

  4. Role of gga-miR-221 and gga-miR-222 during Tumour Formation in Chickens Infected by Subgroup J Avian Leukosis Virus.

    Science.gov (United States)

    Dai, Zhenkai; Ji, Jun; Yan, Yiming; Lin, Wencheng; Li, Hongxin; Chen, Feng; Liu, Yang; Chen, Weiguo; Bi, Yingzuo; Xie, Qingmei

    2015-12-11

    Subgroup J avian leukosis virus (ALV-J) causes a neoplastic disease in infected chickens. Differential expression patterns of microRNAs (miRNAs) are closely related to the formation and growth of tumors. (1) BACKGROUND: This study was undertaken to understand how miRNAs might be related to tumor growth during ALV-J infection. We chose to characterize the effects of miR-221 and miR-222 on cell proliferation, migration, and apoptosis based on previous microarray data. (2) METHODS: In vivo, the expression levels of miR-221 and miR-222 were significantly increased in the liver of ALV-J infected chickens (p J infection. They may also play a pivotal role in tumorigenesis during ALV-J infection.

  5. Estimating the input of submarine groundwater discharge (SGD) and SGD-derived nutrients in Geoje Bay, Korea using (222)Rn-Si mass balance model.

    Science.gov (United States)

    Hwang, Dong-Woon; Lee, In-Seok; Choi, Minkyu; Kim, Tae-Hoon

    2016-09-15

    In order to evaluate the main source of nutrients for maintaining the high production in shellfish farming bay, we have measured (222)Rn activities and the concentrations of nutrients in stream water, seawater, and coastal groundwater around Geoje Bay, one of the largest cultivation areas of oyster in the southern sea of Korea in April 2013. Using the (222)Rn and Si mass balance model, the residence time of bay seawater was about 5days and the submarine groundwater discharge (SGD) into the bay was estimated to be approximately 1.8×10(6)m(3) d(-1). The SGD-derived nutrient fluxes contributed approximately 54% for DIN, 5% for DIP, and 50% for DSi of total nutrient input entering into the bay. Thus, our results suggest that SGD is the major source of nutrients in Geoje Bay, and SGD-derived nutrients are very important to support the biological production of this shellfish farming bay. PMID:27377001

  6. A study of radon 222 permeation through plastic membranes. Application to a method of radon measurement in water and saturated soils

    International Nuclear Information System (INIS)

    In order to improve the BARASOLR device and to use it in water-saturated soils and in pressure constraint conditions, we have studied radon 222 permeation through plastic membranes. While the permeation process usually takes place between two media being in the same state, most often gaseous, the present study describes the transfer of radon 222 from the water to the air via a membrane. Polypropylene membranes have been tested with an experimental set-up by monitoring the evolution of radon concentrations in water and in air. The permeation coefficient and the activation energy were calculated in various conditions. With a second experimental set-up, we have tested the polyethylene membrane which has been adapted on the BARASOL. In these conditions, we have shown that it is possible to measure radon in water at concentrations around 103 Bq.m-3

  7. Single-pass UV generation at 222.5 nm based on high-power GaN external cavity diode laser.

    Science.gov (United States)

    Ruhnke, N; Müller, A; Eppich, B; Güther, R; Maiwald, M; Sumpf, B; Erbert, G; Tränkle, G

    2015-05-01

    We demonstrate a compact system for single-pass frequency doubling of high-power GaN diode laser radiation. The deep UV laser light at 222.5 nm is generated in a β-BaB2O4 (BBO) crystal. A high-power GaN external cavity diode laser (ECDL) system in Littrow configuration with narrowband emission at 445 nm is used as pump source. At a pump power of 680 mW, a maximum UV power of 16 μW in continuous-wave operation at 222.5 nm is achieved. This concept enables a compact diode laser-based system emitting in the deep ultraviolet spectral range.

  8. Temporal behavior of 222Radon, 226Radium and 238Uranium in deep water wells which provide Valle de Toluca with drinking water

    International Nuclear Information System (INIS)

    The presence of radionuclides in underground waters may be an indication of its origin and also the sign of the hydraulic properties of the aquifers layers where circulate. Additionally, the ingestion by human beings of water with radioactive elements (Radon 222, Radium 226, Uranium 238) can give as a result the accumulation of such elements in several organs of the body producing then health damages. In this work, the concentrations of Radon 222, Radium 226 and Uranium 238, in waters coming from deep wells which provide with drinking water the Toluca Valley, were determined. For this purpose, during a year (june 1991 to August 1992) ten wells were sampled with a tracking of the radionuclides concentration as well as the physical-chemical components of water; it was established the relationship presented by the analyzed waters with the local geology and the local and regional systems. (Author)

  9. Single-pass UV generation at 222.5 nm based on high-power GaN external cavity diode laser.

    Science.gov (United States)

    Ruhnke, N; Müller, A; Eppich, B; Güther, R; Maiwald, M; Sumpf, B; Erbert, G; Tränkle, G

    2015-05-01

    We demonstrate a compact system for single-pass frequency doubling of high-power GaN diode laser radiation. The deep UV laser light at 222.5 nm is generated in a β-BaB2O4 (BBO) crystal. A high-power GaN external cavity diode laser (ECDL) system in Littrow configuration with narrowband emission at 445 nm is used as pump source. At a pump power of 680 mW, a maximum UV power of 16 μW in continuous-wave operation at 222.5 nm is achieved. This concept enables a compact diode laser-based system emitting in the deep ultraviolet spectral range. PMID:25927802

  10. Radon-222 content of natural gas samples from Upper and Middle Devonian sandstone and shale reservoirs in Pennsylvania—preliminary data

    Science.gov (United States)

    Rowan, E.L.; Kraemer, T.F.

    2012-01-01

    Samples of natural gas were collected as part of a study of formation water chemistry in oil and gas reservoirs in the Appalachian Basin. Nineteen samples (plus two duplicates) were collected from 11 wells producing gas from Upper Devonian sandstones and the Middle Devonian Marcellus Shale in Pennsylvania. The samples were collected from valves located between the wellhead and the gas-water separator. Analyses of the radon content of the gas indicated 222Rn (radon-222) activities ranging from 1 to 79 picocuries per liter (pCi/L) with an overall median of 37 pCi/L. The radon activities of the Upper Devonian sandstone samples overlap to a large degree with the activities of the Marcellus Shale samples.

  11. Activity of radon (222Rn) in the lower atmospheric surface layer of a typical rural site in south India

    Science.gov (United States)

    Kumar, K. Charan; Prasad, T. Rajendra; Ratnam, M. Venkat; Nagaraja, Kamsali

    2016-09-01

    Analysis of one year measurements of in situ radon (222Rn) and its progenies along with surface air temperature, relative humidity and pressure near to the Earth's surface has been carried out for the first time at the National Atmospheric Research Laboratory (NARL, 13.5∘N and 79.2∘E) located in a rural site in Gadanki, south India. The dataset was analysed to understand the behaviour of radon in relation to the surface air temperature and relative humidity at a rural site. It was observed that over a period of the 24 hours in a day, the activity of radon and its progenies reaches a peak in the morning hours followed by a remarkable decrease in the afternoon hours. Relatively, a higher concentration of radon was observed at NARL during fair weather days, and this can be attributed to the presence of rocky hills and dense vegetation surrounding the site. The high negative correlation between surface air temperature and activity of radon (R = - 0.70, on an annual scale) suggests that dynamical removal of radon due to increased vertical mixing is one of the most important controlling processes of the radon accumulation in the atmospheric surface layer. The annual averaged activity of radon was found to be 12.01±0.66 Bq m-3 and 4.25±0.18 Bq m-3 for its progenies, in the study period.

  12. Determination of 222Rn levels in houses, schools and hotels of Ramsar by AEOI passive radon diffusion dosimeters

    International Nuclear Information System (INIS)

    Radon-222 levels were determined in 473 rooms of about 350 houses, 16 schools in Ramsar and its high-level natural radiation areas (HLNRAs) as well as in 89 rooms and many locations of old and new Ramsar Hotels. The AEOI (Atomic Energy Organization of Iran) Radon Diffusion Dosimeters applying electrochemical etching of polycarbonate detectors were used indoors during different seasons. The levels measured ranged from 20 to 3700 Bq.m-3, detected in Talesh Mahalleh which has the highest natural radiation level in the area, corresponding to effective dose equivalents (He) up to 98.5 mSv.a-1. The mean radon levels determined in different regions were 615 Bq.m-3 in Talesh Mahalleh, 326 Bq.m-3 in Chaparsar, 258 Bq.m-3 in schools of Ramsar and its HLNRAs, 246 Bq.m-3 in Ramak, 111 Bq.m-3 in Rasmar city, 50 Bq.m-3 in Sadat Mahalleh and Katalom, 49 Bq.m-3 Tonekabon and 27 Bq.m-3 in Talesh Mahalleh of Katalom; and 90 Be.m-3 in old and 50 Bq.m-3 in new Ramsar Hotels. It was found that houses built at a higher level above the ground even in the areas with the highest gamma exposures have lower radon levels compared to those built directly on the ground. The results of the radon levels determined in the above regions indoors are presented. (author). 10 refs, 9 figs, 3 tabs

  13. The radon 222 transport in soils. The case of the storage of residues coming from uranium ores processing

    International Nuclear Information System (INIS)

    Uranium Mill Tailings (UMT) contain comparatively large quantities of radium-226. This radionuclide yields, by radioactive decay, the radioactive gas radon-222. Tailing piles are routinely covered to reduce the radon release-rate into the atmosphere. In order to assess the long term environmental impact of a UMT repository, mechanisms governing radon exhalation at the soil surface must be deciphered and understood. A model of radon transport in the unsaturated zone is developed for this purpose: water- and air-flow in the porous material are determined, as well as radon transport by diffusion in the pore space and advection by the gas phase. The radon transport model in the unsaturated zone - TRACI (which stands, in French, for Radon Transport within the Unsaturated Layer) - calculates moisture contents in the soil, Darcy's velocities of the liquid and gas phases, radon concentrations in the gas phase and radon flux at the soil surface. TRACI's results are compared with observations carried out on a UMT and a cover layer. Input parameters are derived from the textural analysis of the material under study, whereas upper boundary conditions are given by meteorological data. If we consider measurement errors and uncertainties on the porous medium characterisation, model's results are generally in good agreement with observations, at least on the long run. Moreover, data analysis shows hat transient phenomena are understood as well, in most situations. (author)

  14. Development and physical analysis of YAC contigs covering 7 Mb of Xp22.3-p22.2

    Energy Technology Data Exchange (ETDEWEB)

    Herrell, S.; Novo, F.J.; Charlton, R. [Univ. of Cambridge (United Kingdom)] [and others

    1995-01-20

    A total of YAC clones have been isolated from the region of Xp22.2-p22.3 extending from the amelogenin gene locus to DXS31. Restriction analysis of these clones in association with STS contenting and end clone analysis has facilitated the construction of 6 contigs covering a total of 7 Mb in which 20 potential CpG islands have been located. Thirty new STSs have been developed from probe and YAC end clone sequences, and these have been used in the analysis of patients suffering from different combinations of chondrodysplasia punctata, mental retardation, X-linked ichthyosis, and Kallmann syndrome. The results suggest that (1) the gene for chondrodysplasia punctata must lie between the X chromosome pseudoautosomal boundary (PABX) and DXS1145; (2) a gene for mental retardation lies between DXS1145 and the sequence tagged site GS1; and (3) the gene for ocular albinism type 1 lies proximal to the STS G13. The CpG islands within the YAC contigs constitute valuable markers for the potential positions of genes. Genes found associated with any of these potential CpG islands would be possible candidates for the disease genes mentioned above. 47 refs., 3 figs., 5 tabs.

  15. Activity of radon ($^{222}$Rn) in the lower atmospheric surface layer of a typical rural site in south India

    Indian Academy of Sciences (India)

    K Charan Kumar; T Rajendra Prasad; M Venkat Ratnam; Nagaraja Kamsali

    2016-10-01

    Analysis of one year measurements of in situ radon ($^{222}$Rn) and its progenies along with surface air temperature, relative humidity and pressure near to the Earth’s surface has been carried out for the first time at the National Atmospheric Research Laboratory (NARL, 13.5◦N and 79.2◦E) located in a rural site in Gadanki, south India. The dataset was analysed to understand the behaviour of radon inrelation to the surface air temperature and relative humidity at a rural site. It was observed that over a period of the 24 hours in a day, the activity of radon and its progenies reaches a peak in the morning hours followed by a remarkable decrease in the afternoon hours. Relatively, a higher concentration of radon was observed at NARL during fair weather days, and this can be attributed to the presence ofrocky hills and dense vegetation surrounding the site. The high negative correlation between surface air temperature and activity of radon (R = – 0.70, on an annual scale) suggests that dynamical removal of radon due to increased vertical mixing is one of the most important controlling processes of the radon accumulation in the atmospheric surface layer. The annual averaged activity of radon was found to be12.01±0.66 Bq m$^{−3}$ and 4.25±0.18 Bq m$^{−3}$ for its progenies, in the study period.

  16. Evaluation of {sup 222}radon occupational exposure in underground workplaces: tunnels used for mushroom cultivation in Italy

    Energy Technology Data Exchange (ETDEWEB)

    Fontana, C.; Vecchiariello, S.; Angeloni, U. [Laboratory of Environmental Radioactivity - Central Laboratory, ITALIAN RED CROSS, Rome (Italy); Trevisi, R.; Tonnarini, S. [Radon Measurement Laboratory - Department of Occupational Hygiene, ISPESL, Rome (Italy)

    2006-07-01

    The mushroom cultivation in tunnels represents a working activity with interesting characteristics from a radiological protection point of view. The practice of using tunnels or caves for the cultivation of mushrooms is diffused in many countries as well as in several Italian regions. These places are characterized by micro climate conditions (temperature, humidity, etc.) particularly adapted for the growth of mushrooms in every period of the year. This practice, like every working activity carried out in underground workplaces, is regulated by the Italian implementation of the European Union Basic Safety Standards (E.U. B.S.S., 1996). With the aim to evaluate the {sup 222}Rn exposure of workers in tunnels used for mushroom cultivation, a study has been undertaken. In particular, hygienic and micro climatic characteristics (depth, temperature, relative humidity, barometric pressure, ventilation, etc.) and radiometric parameters (indoor radon concentration, radon decay products concentration, equilibrium factor F) have been investigated. In the present paper, the results of the two steps of the study are reported. In the first step, an operative protocol has been defined: the protocol was put through a series of measurements in two tuff tunnels in the area of Rome. In the second step, several tunnels used for mushroom cultivation, located in different Italian regions, have been monitored and experimental data have been used to estimate annual effective doses of workers due to radon inhalation.The experimental results have been analyzed in the context of the E.U. B.S.S.

  17. Radon 222 tracing of soil and forest canopy trace gas exchange in an open canopy boreal forest

    Science.gov (United States)

    Ussler, William, III; Chanton, Jeffrey P.; Kelley, Cheryl A.; Martens, Christopher S.

    1994-01-01

    A set of continuous, high-resolution atmospheric radon (Rn-222) concentration time series and radon soil flux measurements were acquired during the summer of 1990 at a micrometeorological tower site 13 km northwest of Schefferville, Quebec, Canada. The tower was located in a dry upland, open-canopy lichen-spruce woodland. For the period July 23 to August 1, 1990, the mean radon soil flux was 41.1 +/- 4.8 Bq m(exp -2)/h. Radon surface flux from the two end-member forest floor cover types (lichen mat and bare soil) were 38.8 +/- 5.1 and 61.8 +/- 15.6 Bq m(exp -2)/h, respectively. Average total forest canopy resistances computed using a simple 'flux box' model for radon exchange between the forest canopy and the overlying atmosphere range from 0.47 +/- 0.24 s cm(exp -1) to 2.65 +/- 1.61 cm(exp -1) for daytime hours (0900-1700 LT) and from 3.44 +/- 0.91 s cm(exp -1) to 10.55 +/- 7.16 s cm(exp -1) for nighttime hours (2000-0600) for the period July 23 to August 6, 1990. Continuous radon profiling of canopy atmospheres is a suitable approach for determining rates of biosphere/atmosphere trace gas exchange for remote field sites where daily equipment maintenance is not possible. where daily equipment maintenance is not possible.

  18. Observation of {sup 222}Rn progeny-and {sup 220}Rn progeny-loaded aerosols by atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Leung, J.K.C.; Tso, M.Y.W.; Lam, J.H.C. [The Univ., of Hong Kong, Hong Kong (China); Zhau, Q.F. [Ministry of Health, Beijing (China)

    2002-07-01

    Atomic force microscopy is becoming a powerful tool for the study of nuclear tracks in materials such as CR-39. Coupled with its capability of observing near nm aerosol particles, we have utilized the AFM to observe the radon progeny-loaded aerosol particles deposited on surfaces of CR-39 and to observe the corresponding etch pits produced by the {alpha} -particles emitted from the radon progenies. A special platform was built so that after the aerosol particles on the CR-39 have been scanned and recorded, the CR-39 can be etched and then scanned for the etch pits at the same location. Both {sup 222}Rn and {sup 220}Rn progenies were used in the study. The progenies were generated by the appropriate radon sources and mixed with aerosol particles generated by aerosol generators. The aerosol size distributions were analyzed by a scanning mobility particle sizer. Some of the limitations and difficulties of the technique will be described. The results enable us to examine the attachment process including multiple attachments of radon progenies on aerosols.

  19. Dynamics, deterministic nature and correlations of outdoor {sup 222}Rn and {sup 220}Rn progeny concentrations measured at Bacau, Romania

    Energy Technology Data Exchange (ETDEWEB)

    Cuculeanu, Vasile, E-mail: cuculeanu@gmail.com [Faculty of Physics, University of Bucharest, Magurele, RO-077125 Bucharest (Romania); Simion, Florin [Faculty of Physics, University of Bucharest, Magurele, RO-077125 Bucharest (Romania); National Environmental Protection Agency, Radioactivity Laboratory, Splaiul Independentei 294, RO-060031 Bucharest (Romania); Simion, Elena [National Environmental Protection Agency, Radioactivity Laboratory, Splaiul Independentei 294, RO-060031 Bucharest (Romania); Geicu, Anton [National Administration of Meteorology, Bucharest (Romania)

    2011-07-15

    The long-term variation, nature and correlations of outdoor {sup 222}Rn and {sup 220}Rn progeny concentrations measured during the period 1994-2009 were investigated. The time series of data were obtained within the framework of the monitoring program performed by the Environmental Radioactivity Monitoring Station (ERMS) Bacau, a component part of the National Environmental Radioactivity Survey Network (NERSN), coordinated by National Environmental Protection Agency (NEPA). The measuring method is based on the total beta measurements of atmospheric aerosol filters, using a low background total beta counter and ({sup 90}Sr/Y) reference standard. Analysis of the time series of progeny concentrations in the low atmosphere makes evident different patterns of variation of these concentrations: diurnal, seasonal and annual. A possible relationship of progeny concentration increase with global warming is emphasized. In order to find the dominant frequency of the physical processes determining progeny concentration variability the power spectrum has been used. The deterministic nature of the time series of concentrations has been studied making use of the autocorrelation function and stationarity of the original data and of their phase randomized time series. Also, the correlations with meteorological parameters have been investigated using Pearson's correlation coefficient with corresponding level of significance. - Highlights: > Radon and thoron progeny concentrations measured on a period of 16 years. > 5 h, daily, monthly and annual patterns are pointed out. > Autocorrelation functions prove non-randomness of concentrations. > Deterministic nature of time series of concentrations is demonstrated. > Correlations with meteorological data are studied.

  20. A simple method for calibration of Lucas scintillation cell counting system for measurement of 226Ra and 222Rn

    Directory of Open Access Journals (Sweden)

    N.K. Sethy

    2014-10-01

    Full Text Available Known quantity of radium from high grade ore solution was chemically separated and carefully kept inside the cavity of a Lucas Cell (LC. The 222Rn gradually builds up and attain secular equilibrium with its parent 226Ra. This gives a steady count after a suitable buildup period (>25 days. This secondary source was used to calibrate the radon counting system. The method is validated in by comparison with identical measurement with AlphaGuard Aquakit. The radon counting system was used to evaluate dissolved radon in ground water sample by gross alpha counting in LC. Radon counting system measures the collected radon after a delay of >180 min by gross alpha counting. Simultaneous measurement also carried out by AlphaGuard Aquakit in identical condition. AlphaGuard measures dissolved radon from water sample by constant aeration in a closed circuit without giving any delay. Both the methods are matching with a correlation coefficient of >0.9. This validates the calibration of Lucas scintillation cell counting system by designed encapsulated source. This study provides an alternative for calibration in absence of costly Radon source available in the market.

  1. Compound heterozygosity with a novel S222N GALT mutation leads to atypical galactosemia with loss of GALT activity in erythrocytes but little evidence of clinical disease

    OpenAIRE

    Benjamin Cocanougher; Umut Aypar; Amber McDonald; Linda Hasadsri; Bennett, Michael J; Edward Highsmith, W.; Kristin D'Aco

    2015-01-01

    Galactosemia is an inborn error of galactose metabolism caused by mutations in the GALT gene. Though early detection and galactose restriction prevent severe liver disease, affected individuals have persistently elevated biomarkers and often neuro-developmental symptoms. We present a teenage compound heterozygote for a known pathogenic mutation (H132Q) and a novel variant of unknown significance (S222N), with nearly absent erythrocyte GALT enzyme activity but normal biomarkers and only mild a...

  2. Olfactory nerve response of masu salmon (Oncorhynchus masou Brevoort) and rainbow trout (O. mykiss Walbaum) to clove oil and MS-222

    OpenAIRE

    YAMAMOTO, Yuzo; Woody, Carol A; Shoji, Takayuki; Ueda, Hiroshi

    2008-01-01

    Two anaesthetics, clove oil and MS-222, were examined for their effects on the olfactory nerve response of masu salmon (Oncorhynchus masou) and rainbow trout (O. mykiss). Exposing fish to clove oil for 3 minutes at concentrations of 50 mg/L and 100 mg/L, or for 10 minutes at 50 mg/L, did not significantly reduce their olfactory response. Directly applying clove oil anaesthesia to the olfactory epithelium significantly reduced olfactory response, though olfactory response recovered to 70% and ...

  3. Expression of serum microRNAs( miR-222,miR-181,miR-216 ) in human hepatocellular carcinoma and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    占美晓

    2013-01-01

    Objective To investigate the abnormal expression of microRNAs (miR-216,miR-222,miR-181) in the serum of patients with hepatocellular carcinoma (HCC) and its clinical significance.Methods Serum miRNAs expression was investigated in 49 patients with HCC and 25healthy normal controls by using real-time PCR technique,and then correlations between miRNAs expression

  4. Syntheses of Four Enantiomers of 2,3-Diendo- and 3-Endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic Acid and Their Saturated Analogues

    Directory of Open Access Journals (Sweden)

    Márta Palkó

    2013-12-01

    Full Text Available Ethyl 2,3-diendo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylate ((±-1 was resolved with O,O'-dibenzoyltartaric acid via diastereomeric salt formation. The efficient synthesis of the enantiomers of 2,3-diendo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acid ((+-7 and (–-7, 3-endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic acid ((+-5 and (–-5, cis- and trans-3-aminobicyclo[2.2.2]octane-2-carboxylic acid ((+-6, (–-6, (+-8 and (–-8 was achieved via isomerization, hydrogenation and hydrolysis of the corresponding esters (–-1 and (+-1. The stereochemistry and relative configurations of the synthesized compounds were determined by NMR spectroscopy (based on the 3J(H,H coupling constants and X-ray crystallography.

  5. Natural 222Rn and 220Rn indicate the impact of the Water–Sediment Regulation Scheme (WSRS) on submarine groundwater discharge in the Yellow River estuary, China

    International Nuclear Information System (INIS)

    Highlights: • 220Rn and 222Rn were combined to locate intensive SGD sites. • Influence of WSRS to SGD was found for the first time. • SGD was a dominant nutrient pathway in the Yellow River estuary. - Abstract: Submarine groundwater discharge (SGD) in estuaries brings important influences to coastal ecosystems. In this study, we observed significant SGD in the Yellow River estuary, including a fresh component, during the Water–Sediment Regulation Scheme (WSRS) period. We used the 222Rn and 220Rn isotope pair to locate sites of significant SGD within the study area. Three apparent SGD locations were found during a non-WSRS period, one of which became much more pronounced, according to the remarkably elevated radon levels, during the WSRS. Increased river discharge (from 245 m3 s−1 to 3560 m3 s−1) and the elevated river water level (from 11 m to 13 m) during the WSRS led to a higher hydraulic head, enhancing groundwater discharge in the estuary. Our results suggest that high river discharge (>3000 m3 s−1) might be necessary for elevated fresh submarine groundwater discharging (FSGD). Vertical profiles of salinity, DO and turbidity anomalies along the benthic boundary layer also indicated significant FSGD in the estuary during the WSRS. Nutrient concentrations had positive correlations with 222Rn during a 24-h observation, which indicates that SGD is a dominant nutrient pathway in this area

  6. EGFR Signaling Pathway and Related-miRNAs In Age-related Diseases: The Example of miR-221 and miR-222

    Directory of Open Access Journals (Sweden)

    Ana L Teixeira

    2012-12-01

    Full Text Available Presently, neurodegenerative diseases and cancer are the most clinically problematic age-related diseases worldwide. Although being distinct disorders, their developments share common cellular mechanisms. Oncogenesis and neurodegeneration arise from the deregulation of signaling pathways, as a consequence of the resulting imbalance in cellular homeostasis. The epidermal growth factor receptor (EGFR belongs to an important cellular signaling pathway, which regulates proliferation, differentiation, cell cycle and migration. As transcriptional targets of EGFR, the microRNAs-221/222 (miR-221/222 are important expression regulators. Dysfunctions in their networks are associated with cellular disruptions. The transcriptional activation of these miRNAs seems to be involved in cell cycle, apoptosis, metastization and in the acquisition of resistance to therapies. The up-regulation of miR-221/222 is associated with increased expression levels of matrix metalloproteinases (MMPs and repression of cell cycle inhibitors, which are key molecules in oncogenesis and neurodegeneration processes. The interaction loop between proliferative signaling pathways and miRNA expression could reveal new targets for controlling the molecular behavior of age-related diseases.

  7. Biochemical and computational analyses of two phenotypically related GALT mutations (S222N and S135L) that lead to atypical galactosemia.

    Science.gov (United States)

    Cocanougher, Benjamin; Aypar, Umut; McDonald, Amber; Hasadsri, Linda; Bennett, Michael J; Edward Highsmith, W; D׳Aco, Kristin

    2015-06-01

    Galactosemia is a metabolic disorder caused by mutations in the GALT gene [1,2]. We encountered a patient heterozygous for a known pathogenic H132Q mutation and a novel S222N variant of unknown significance [3]. Reminiscent of patients with the S135L mutation, our patient had loss of GALT enzyme activity in erythrocytes but a very mild clinical phenotype [3-8]. We performed splicing experiments and computational structural analyses to investigate the role of the novel S222N variant. Alamut software data predicted loss of splicing enhancers for the S222N and S135L mutations [9,10]. A cDNA library was generated from our patient׳s RNA to investigate for splicing errors, but no change in transcript length was seen [3]. In silico structural analysis was performed to investigate enzyme stability and attempt to understand the mechanism of the atypical galactosemia phenotype. Stability results are publicly available in the GALT Protein Database 2.0 [11-14]. Animations were created to give the reader a dynamic view of the enzyme structure and mutation locations. Protein database files and python scripts are included for further investigation. PMID:26217714

  8. Biochemical and computational analyses of two phenotypically related GALT mutations (S222N and S135L that lead to atypical galactosemia

    Directory of Open Access Journals (Sweden)

    Benjamin Cocanougher

    2015-06-01

    Full Text Available Galactosemia is a metabolic disorder caused by mutations in the GALT gene [1,2]. We encountered a patient heterozygous for a known pathogenic H132Q mutation and a novel S222N variant of unknown significance [3]. Reminiscent of patients with the S135L mutation, our patient had loss of GALT enzyme activity in erythrocytes but a very mild clinical phenotype [3–8]. We performed splicing experiments and computational structural analyses to investigate the role of the novel S222N variant. Alamut software data predicted loss of splicing enhancers for the S222N and S135L mutations [9,10]. A cDNA library was generated from our patient׳s RNA to investigate for splicing errors, but no change in transcript length was seen [3]. In silico structural analysis was performed to investigate enzyme stability and attempt to understand the mechanism of the atypical galactosemia phenotype. Stability results are publicly available in the GALT Protein Database 2.0 [11–14]. Animations were created to give the reader a dynamic view of the enzyme structure and mutation locations. Protein database files and python scripts are included for further investigation.

  9. Influence of the decay products of 222Rn on the background counting rate of a sensitive whole-body radioactive monitor

    International Nuclear Information System (INIS)

    The background counting rates of a sensitive whole-body radioactivity monitor and the decay products of 222Rn have been measured simultaneously. The background counting rate and the concentrations do not show a simple relationship because of the deposition of decay products on the surfaces in the shielded space of the monitor. 'Plate out' of decay products at concentrations of the order of 1 pCi/l has been clearly demonstrated. Contributions from airborne radioactivity and deposited radioactivity to the background counting rate are shown to be of the same order. Deposition of radioactivity due to the presence of electrostatic charges on the surface of polythene is shown to be reduced by covering it with a conducting foil. The increase in background counting rate when uncovered polythene phantoms are used in calibration work is demonstrated. It is recommended that the use of bare polythene phantoms must be discontinued in the light of this study. The advantage of high turnover rates of air into the shielded space to prevent accumulation of decay products of 222Rn is likely to be offset by the deposition of radioactivity on surfaces of synthetic materials used in the monitor. The small but variable contribution to the background counting rate from decay products of 222Rn is undesirable when scrupulous precautions are taken to reduce the traces of radioactive impurities in the materials used in fabricating the monitor. (Auth.)

  10. Indoor {sup 22}Rn and {sup 222}Rn concentration measurements inside the Teotihuacan pyramids using NTD and E-PERM methodologies

    Energy Technology Data Exchange (ETDEWEB)

    Espinosa, G. [Instituto de Fisica, UNAM, Apartado Postal 20-364, 01000 Mexico, D.F. (Mexico)]. E-mail: espinosa@fisica.unam.mx; Golzarri, J.I. [Instituto de Fisica, UNAM, Apartado Postal 20-364, 01000 Mexico, D.F. (Mexico); Martinez, T. [Facultad de Quimica, UNAM, Edificio D, Ciudad Universitaria, Mexico, D.F. (Mexico); Navarrete, M. [Facultad de Quimica, UNAM, Edificio D, Ciudad Universitaria, Mexico, D.F. (Mexico); Bogard, J. [Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831-6480 (United States); Martinez, G. [Coordinacion Nacional de Conservacion del Patrimonio Cultural, Xicotencatl y General Anaya s/n, 04120 Mexico, D.F. (Mexico); Juarez, F. [Instituto de Geofisica, UNAM, Ciudad Universitaria, 04510 Mexico, D.F. (Mexico)

    2005-11-15

    Measurements of {sup 22}Rn (Thoron) and {sup 222}Rn (Radon) concentrations, inside the Sun and Moon pyramids of Teotihuacan's archeological zone in Mexico, are reported in this work. Two well-established methods, nuclear track detectors (NTDs), using open-close end cups with internal and external detectors of CR-39 polymer, and electret-passive environmental radon monitoring (E-PERM) were used for the measurements. This experiment had two objectives: to obtain better confidence in the {sup 22}Rn and {sup 222}Rn measurements inside the archeological tunnels, and to compare the data obtained in each one of the two methods. This experiment is specially interesting because of the very peculiar conditions where the measurements are made: high humidity, labyrinths with air currents, but almost constant temperature inside of the pyramid tunnels and galleries, notwithstanding of the temperature changes between the day and the night outside of the pyramid body. The {sup 222}Rn concentrations found in both the pyramids were lower than the action level proposed by the ICRP-65. These tunnels are not open to the public, but researchers from the Anthropology Institutions spend part of their time working there, in periods varying from 3 to 5 months.

  11. Roles of phenylalanine at position 120 and glutamic acid at position 222 in the oxidation of chiral substrates by cytochrome P450 2D6.

    Science.gov (United States)

    Masuda, Kazufumi; Tamagake, Keietsu; Katsu, Takashi; Torigoe, Fumihiro; Saito, Keita; Hanioka, Nobumitsu; Yamano, Shigeru; Yamamoto, Shigeo; Narimatsu, Shizuo

    2006-02-01

    The roles of Phe-120 and Glu-222 in the oxidation of chiral substrates bunitrolol (BTL) and bufuralol (BF) by CYP2D6 are discussed. Wild-type CYP2D6 (CYP2D6-WT) oxidized BTL to 4-hydroxybunitrolol (4-OH-BTL) with substrate enantioselectivity of (R)-(+)-BTL > (S)-(-)-BTL. The same enzyme converted BF into 1''-hydroxybufuralol with substrate enantioselectivity of (R)-BF > (S)-BF and metabolite diastereoselectivity of (1''R)-OH kinetic parameters (K(m) and V(max) values) for (R)-BF 1''-hydroxylation remained unchanged. Furthermore, the substitution of Glu-222 as well as Glu-216 by alanine remarkably decreased both the apparent K(m) and V(max) values without changing substrate enantioselectivity or metabolite diastereoselectivity. A computer-assisted simulation study using energy minimization and molecular dynamics techniques indicated that the hydrophobic interaction of an aromatic moiety of the substrate with Phe-120 and the ionic interaction of a basic nitrogen atom of the substrate with Glu-222 in combination with Glu-216 play important roles in the binding of BF and BTL by CYP2D6 and the orientation of these substrates in the active-site cavity. This modeling yielded a convincing explanation for the reversal of substrate enantioselectivity in BTL 4-hydroxylation between CYP2D6-WT and CYP2D6-V374M having methionine in place of Val-374, which supports the validity of this modeling.

  12. Collection of emanating 222Rn for the preparation of a 210Pb-210Po alpha-source and the building of a mobile random pulse and probability generator utilizing alpha-counting technique

    International Nuclear Information System (INIS)

    A random pulse and probability generator (RPG) has been developed utilizing the detection technique of alpha-particles as the random signal source. The collection technique for 222Rn emanated from natural uranium ore was examined for preparing highly pure 210Pb-210Po as an alpha source for RPG. The yield with a trap refrigerated by liquid nitrogen was observed to be above 99% for 222Rn collection. (author)

  13. Evaluation of natural radionuclide occurrence (Rn-222) in a nuclear facility that processes UF{sub 6} for the UO{sub 2} powder and pellet productions; Avaliacao da ocorrencia de nuclideos naturais (Rn-222) em uma instalacao nuclear que processa UF{sub 6} para a producao de po e pastilha de UO{sub 2} that processes UF{sub 6} for the UO{sub 2} powder

    Energy Technology Data Exchange (ETDEWEB)

    Mouco, Charles Dickens do Carmo Lacerda; Matta, Luiz Ernesto Santos Carvalho [Instituto de Radioprotecao e Dosimetria (IRD), Rio de Janeiro, RJ (Brazil)

    2001-07-01

    This paper presents the early data from the concentration evaluation of Rn-222 in a nuclear facility that processes UF{sub 6} for the UO{sub 2} powder and tablet productions. Measurements were accomplished in the same points and under the same climatic conditions with the factory working and not working. The results showed that no significant alteration was detected in the obtained values in both situations. The average value was 15 and 18 Bq/m3 for operating and not operating respectively. There is no significant difference between data. The concentrations values of Rn-222 are lower than the internationally established limits for this radionuclide. The Rn-222 concentration values obtained, are probably originated from the building material, and the Rn-222 concentration levels are due to the great air exchange inside the factory. (author)

  14. Intensidade de ruído em hospital de 222 leitos na 18ª Regional de Saúde - PR Noise level in a 222 bed hospital in the 18th health region - PR

    Directory of Open Access Journals (Sweden)

    Marcelo Henrique Otenio

    2007-04-01

    Full Text Available A poluição sonora ambiental torna-se hoje onipresente e beira o intolerável. Nos hospitais, os avanços tecnológicos trazem, como conseqüência, níveis de ruído potencialmente danosos. Muito do ruído no hospital provém mais de dentro, do que de fora desse ambiente, sendo as principais causas de ruído em Unidade de Terapia Intensiva, por exemplo, os equipamentos e a conversação entre a equipe hospitalar. O objetivo deste trabalho foi avaliar o nível de ruído nos diversos ambientes hospitalares, em Hospital de 222 leitos na 18ª RS de Saúde - PR. MATERIAIS E MÉTODOS: Conduziu-se, em março de 2005 no período de 24 horas, em dez setores. Forma de Estudo: Aferição do nível de ruído ambiental utilizando um Decibelímetro modelo 1350. RESULTADOS: O nível de ruído encontrado em nosso estudo apresentou média total de 63,7 dB(A, que excede os valores máximos permitidos de 45 dB recomendados pela Associação Brasileira de Normas Técnicas (1987. CONCLUSÃO: Nos setores analisados, o nível de ruído encontrado neste está consideravelmente acima do recomendado. A equipe hospitalar deve estar consciente do ruído e dos efeitos deste, para que possa atuar de maneira mais efetiva na redução da poluição sonora, beneficiando assim a função laborativa dos profissionais e recuperação dos pacientes.Environment noise pollution is common place today, at intolerable levels. In hospitals, technological developments have, as a consequence, potentially harmful noise levels. Much of the hospital noise comes from inside, rather than outside, and the major source of such noise is the Intensive Care Unit, for example equipment and hospital staff talk. Our goal with the present study was to investigate the noise level present in the different hospital environments, within a 222 bed hospital located at the 18th health zone, PR. MATERIALS AND METHODS: The study was carried out in March, 2005, during a period of 24 hours, in tem different

  15. Cytogenetical analysis on 222 patients with Downg syndrome in Guizhou province%贵州省222例唐氏综合征患者的细胞遗传学分析

    Institute of Scientific and Technical Information of China (English)

    张宏红; 周从容; 吴小平; 陈蔚清; 鲜义辉; 冯燕梅; 李映雪

    2011-01-01

    目的:对贵州省222例唐氏综合征患者进行细胞遗传学分析,减少唐氏综合征患儿出生.方法:询问病史、体格检查、抽取静脉血进行淋巴细胞培养,中期染色体制片、G显带处理,每例患者镜下计数30个核型,分析核型3个以上,对异常者加大计数和分析量,并按人类细胞遗传学国际命名体制(ISCN,1985)的标准命名.结果:唐氏综合征者中单纯型占92.35%、易位型占4.05%、嵌合型占2.25%,合并其他染色体异常者占1.35%.结论:细胞遗传学检测是确诊唐氏综合征患儿的可靠方法,针对高龄或有不良因素接触史的孕妇加强孕前优生遗传咨询,进行产前筛查和产前诊断,及时了解胎儿染色体异常情况,对减少唐氏综合征患儿出生有着极其重要的意义.%Objective: To conduct cytogenetical analysis among 222 patients with Down's syndrome, reduce the birth of neonates with Down's syndrome. Methods: The cases received medical history inquiry, physical examination, culture of lymphocytes from venous blood, metaphase chromosome section and G - banding; 30 karyotypes were counted under microscope respectively, more than 3 karyotypes were analyzed; for the cases with abnormal results, the karyotypes amounts of count and analysis were increased, then naming was conducted according to ISCN (1985) . Results: Among the patients with Down's syndrome, the proportions of simple type, translocation type, mosaicism type and combining with other chromosomal abnormalities were 92. 35%, 4. 05%, 2. 25% and 1.35%, respectively. Conclusion: Cytogenetical detection is a reliable method to diagnose Down's syndrome definitely among the infants; prenatal genetic counseling, prenatal screening and prenatal diagnosis should be enhanced among the pregnant women of advanced age or with contact history of adverse factors; fetal chromosomal abnormalities should be understood timely, all the above - mentioned measures are important to reduce the

  16. {sup 220}Rn measurements and implications for earlier surveys of {sup 222}Rn; Meting van {sup 220}Rn en consequenties voor eerdere {sup 222}Rn-surveys. VERA-onderzoek

    Energy Technology Data Exchange (ETDEWEB)

    Blaauboer, R.O.

    2010-08-15

    The concentration of radioactive radon gas (Rn-222) encountered in newly constructed dwellings was lower than that expected from earlier surveys. An investigation into the response of the radon detectors used in these earlier surveys revealed that these were also sensitive to radioactive thoron (Rn-220), of which more appears to be present than originally assumed. This is the primary outcome of a detailed examination of the detectors that resulted from a national study on radiation exposure in Dutch dwellings constructed between 1994 and 2003. Detectors used in international radon comparison studies have only been set to test for radon, not thoron. Consequently, in practice it is not immediately evident that some detectors actually measure thoron as well, which is also reported as radon. The increasing interest shown by the Netherlands for thoron, provoked by survey results that appear to have been strongly affected by this radioactive isotope of radon, is mirrored by many other countries. The thoron found in dwellings seems to originate from a (frequently used) building material, possibly a finishing material, which has a relatively high thoron exhalation rate. It has more recently been determined that for many years a type of plaster was used in the Netherlands that contained phosphogypsum, a material known for its high radon content. However, it is possible that other materials incorporated into finishing layers also contribute to higher indoor thoron levels. A large portion of the total indoor exposure of occupants to radiation is from inhalation of radioactive decay products of radon and thoron. Radon and thoron are formed in the soil and earth-based building materials by radioactive decay and, because they are gaseous, they are able to diffuse into homes and other buildings. Exposure to ionizing radiation in the home accounts for approximately half of the average annual radiation dose received by a Dutch citizen. [Dutch] Er komt minder radioactief radongas

  17. {sup 222} Rn exposure assessment in the caves of Parque Estadual Turistico do Alto Ribeira (PETAR); Avaliacao da exposicao ao {sup 222} Rn nas cavernas do Parque Estadual Turistico do Alto Ribeira (PETAR)

    Energy Technology Data Exchange (ETDEWEB)

    Alberigi, Simone

    2006-07-01

    In the present work, radon concentrations in six caves of PETAR - Parque Estadual Turistico do Alto Ribeira (High Ribeira River Touristic State Park) were carried out with Makrofol E solid state nuclear track detectors (SSNTD) and used to assess the annual effective dose received by regional tour guides. The park has four visitation centers: Santana, Ouro Grosso, Caboclos e Casa de Pedra and receives nearly 40,000 people annually. The caves evaluated were Couto, Agua Suja, Laje Branca, Morro Preto and Santana, from Santana center and Alambari de Baixo from Ouro Grosso center, for being the most frequently visited caves. The exposure period of the SSNTD was, at least, three months, over a period of 26 months, from October 2003 to November 2005.The {sup 222}Rn concentrations lay in a range from 153 Bq.m{sup -3} to 6607 Bq.m{sup -3} and we observed that, in general, for chilly weather, the radon levels decrease. The annual effective dose, considering the most realistic scenario, with geometric mean concentrations, an equilibrium factor of 0.5 and annual exposure time for each cave, varied from 0.2 mSv.a{sup -1} for the Couto cave, strongly ventilated, to 4.0 mSv.a{sup -1} for the Santana cave, the most frequently visited and no external communication. For the worst scenario, with arithmetic mean concentrations, equilibrium factor 1 and annual exposure time for all caves, the annual effective dose was 16.1 mSv.a{sup -1}. All assessed effective doses received by the tour guides are bellow 20 mSv.a{sup -1} suggested as an annual effective dose limit for occupational exposure by the International Commission of Radiological Protection (ICRP 60, 1990). (author)

  18. Development, implementation and utilization of 210Pb in vivo measurement techniques as indicator of human being exposure to 222Rn - evaluation of associated parameters

    International Nuclear Information System (INIS)

    Radon and its decay products are present in the atmosphere and are the most important contributors for the internal exposure of humans to natural radiation. The execution of in vivo measurements of 210Pb in the population and in individuals occupationally exposed in underground mines has been studied and recommended as one of the procedures for the estimation of the exposure to 222Rn. The metabolism of 210Pb and its distribution within the human body, mainly deposited in the bone tissue, suggests the regions of skull and knee as the most suitable for the in vivo monitoring of such radionuclide. A radiological survey in non uranium mines in Brazil indicated that an underground coal mine in the State of Parana, in the south of Brazil, had high radon concentration. The aim of this work were: (1) To investigate whether underground coal miners may also have elevated 210Pb in the skeleton as a result of occupational exposure to radon in the coal mine; (2) To estimate the committed equivalent dose and the committed effective dose in different incorporation scenarios using a computer code. The calibration and the in vivo measurements of underground coal miners were performed in the IRD-CNEN Whole Body Counter shielded room using an array of four high resolution germanium detectors. The detection system was positioned at the head and knee geometries. The minimum detectable quantity of 210Pb in the skeleton using this methodology was (50 Bq) and the positive results were verified using a mathematical method that applies a moving median smoothing function to the total spectrum for each measurement. In vivo measurements of 210Pb in 6 out of the 32 underground coal miners ranged between 83 Bq and 164 Bq suggesting that these workers received significant occupational cumulative exposure to 222Rn. The simulation of some exposure patterns of 222Rn progeny and 210Pb incorporation showed that the most important contribution for 210Pb skeleton deposition was the intake of 214Pb and

  19. Examining the spatial and temporal variation of groundwater inflows to a valley-to-floodplain river using 222Rn, geochemistry and river discharge: the Ovens River, southeast Australia

    Directory of Open Access Journals (Sweden)

    M. C. L. Yu

    2013-04-01

    Full Text Available Radon (222Rn and major ion geochemistry were used to define and quantify the catchment-scale river-aquifer interactions along the Ovens River in the southeast Murray-Darling Basin, Victoria, Australia, between September 2009 and October 2011. The Ovens River is characterized by the transition from a single channel river residing within a mountain valley in the upper catchment to a multi-channel meandering river on flat alluvial plains in the lower catchment. Overall, the river is dominated by gaining reaches, receiving groundwater from both alluvial and basement aquifers. The distribution of gaining and losing reaches is governed by catchment morphology and lithology. In the upper catchment, rapid groundwater recharge through sediments that have high hydraulic conductivities in a narrow valley produces higher baseflow to the river during wet (high flow periods as a result of hydraulic loading. In the lower catchment, the open and flat alluvial plains, lower rainfall and finer-gained sediments reduce the magnitude and variability of hydraulic gradient between the aquifer and the river, producing lower and constant groundwater inflow. With a small difference between the water table and the river height, small changes in river height or in groundwater level can result fluctuating gaining and losing behaviour along the river. The middle catchment represents a transition in river-aquifer interactions from upper to lower catchment. High baseflow in some parts of the middle and lower catchments is caused by groundwater flow over basement highs. Mass balance calculations based on 222Rn activities indicate that groundwater inflow is 4–22% of total flow with higher baseflow occurring in high flow periods. Uncertainties in gas exchange coefficient and 222Rn activities of groundwater alter the calculated groundwater inflow to 3–35%. Ignoring hyporheic exchange appears not to have a significant impact on the total groundwater estimates. In comparison to

  20. Thermodynamic studies of aqueous solutions of 2,2,2-cryptand at 298.15 K: enthalpy-entropy compensation, partial entropies, and complexation with K+ ions.

    Science.gov (United States)

    Shaikh, Vasim R; Terdale, Santosh S; Ahamad, Abdul; Gupta, Gaurav R; Dagade, Dilip H; Hundiwale, Dilip G; Patil, Kesharsingh J

    2013-12-19

    The osmotic coefficient measurements for binary aqueous solutions of 2,2,2-cryptand (4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8] hexacosane) in the concentration range of ~0.009 to ~0.24 mol·kg(-1) and in ternary aqueous solutions containing a fixed concentration of 2,2,2-cryptand of ~0.1 mol·kg(-1) with varying concentration of KBr (~0.06 to ~0.16 mol·kg(-1)) have been reported at 298.15 K. The diamine gets hydrolyzed in aqueous solutions and needs proper approach to obtain meaningful thermodynamic properties. The measured osmotic coefficient values are corrected for hydrolysis and are used to determine the solvent activity and mean ionic activity coefficients of solute as a function of concentration. Strong ion-pair formation is observed, and the ion-pair dissociation constant for the species [CrptH](+)[OH(-)] is reported. The excess and mixing thermodynamic properties (Gibbs free energy, enthalpy, and entropy changes) have been obtained using the activity data from this study and the heat data reported in the literature. Further, the data are utilized to compute the partial molal entropies of solvent and solute at finite as well as infinite dilution of 2,2,2-cryptand in water. The concentration dependent non-linear enthalpy-entropy compensation effect has been observed for the studied system, and the compensation temperature along with entropic parameter are reported. Using solute activity coefficient data in ternary solutions, the transfer Gibbs free energies for transfer of the cryptand from water to aqueous KBr as well as transfer of KBr from water to aqueous cryptand were obtained and utilized to obtain the salting constant (ks) and thermodynamic equilibrium constant (log K) values for the complex (2,2,2-cryptand:K(+)) at 298.15 K. The value of log K = 5.8 ± 0.1 obtained in this work is found to be in good agreement with that reported by Lehn and Sauvage. The standard molar entropy for complexation is also estimated for the 2,2,2-cryptand