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Sample records for acrb crystallisation highlighted

  1. Unfolding study of a trimeric membrane protein AcrB.

    Science.gov (United States)

    Ye, Cui; Wang, Zhaoshuai; Lu, Wei; Wei, Yinan

    2014-07-01

    The folding of a multi-domain trimeric α-helical membrane protein, Escherichia coli inner membrane protein AcrB, was investigated. AcrB contains both a transmembrane domain and a large periplasmic domain. Protein unfolding in sodium dodecyl sulfate (SDS) and urea was monitored using the intrinsic fluorescence and circular dichroism spectroscopy. The SDS denaturation curve displayed a sigmoidal profile, which could be fitted with a two-state unfolding model. To investigate the unfolding of separate domains, a triple mutant was created, in which all three Trp residues in the transmembrane domain were replaced with Phe. The SDS unfolding profile of the mutant was comparable to that of the wild type AcrB, suggesting that the observed signal change was largely originated from the unfolding of the soluble domain. Strengthening of trimer association through the introduction of an inter-subunit disulfide bond had little effect on the unfolding profile, suggesting that trimer dissociation was not the rate-limiting step in unfolding monitored by fluorescence emission. Under our experimental condition, AcrB unfolding was not reversible. Furthermore, we experimented with the refolding of a monomeric mutant, AcrBΔloop , from the SDS unfolded state. The CD spectrum of the refolded AcrBΔloop superimposed well onto the spectra of the original folded protein, while the fluorescence spectrum was not fully recovered. In summary, our results suggested that the unfolding of the trimeric AcrB started with a local structural rearrangement. While the refolding of secondary structure in individual monomers could be achieved, the re-association of the trimer might be the limiting factor to obtain folded wild-type AcrB. © 2014 The Protein Society.

  2. Stress-assisted crystallisation in anodic titania

    International Nuclear Information System (INIS)

    Vanhumbeeck, Jean-Francois; Tian He; Schryvers, Dominique; Proost, Joris

    2011-01-01

    Research highlights: → Correlations between microstructure and internal stress during Ti anodising are established. → Large internal compressive stresses are accumulated in the film during anodising upto 12 V. →A transition from compressive to tensile stress is observed when the cell voltage exceeds 12 V. → At 40 V, the oxide films consist of two regions with different compositions and microstructures. Crystallisation of amorphous to anatase TiO 2 contributes to the compressive stress relaxation. - Abstract: The relationship between the microstructural and internal stress evolution during Ti anodising is discussed. Samples anodised galvanostatically to 12 V and 40 V, corresponding to different stages of the internal stress evolution, were examined by in-plane and cross-section transmission electron microscopy. Electron diffraction patterns have been complemented with stoichiometry data obtained from energy loss near edge structure spectra. The sample anodised to 40 V was observed to consist of two regions, with a crystallised inner region adjacent to the metal/oxide interface. Crystallisation of this region is associated with the presence of large compressive internal stresses which build up during anodising up to 12 V.

  3. Functional relevance of AcrB Trimerization in pump assembly and substrate binding.

    Directory of Open Access Journals (Sweden)

    Wei Lu

    Full Text Available AcrB is a multidrug transporter in the inner membrane of Escherichia coli. It is an obligate homotrimer and forms a tripartite efflux complex with AcrA and TolC. AcrB is the engine of the efflux machinery and determines substrate specificity. Active efflux depends on several functional features including proton translocation across the inner membrane through a proton relay pathway in the transmembrane domain of AcrB; substrate binding and migration through the substrate translocation pathway; the interaction of AcrB with AcrA and TolC; and the formation of AcrB homotrimer. Here we investigated two aspects of the inter-correlation between these functional features, the dependence of AcrA-AcrB interaction on AcrB trimerization, and the reliance of substrate binding and penetration on protein-protein interaction. Interaction between AcrA and AcrB was investigated through chemical crosslinking, and a previously established in vivo fluorescent labeling method was used to probe substrate binding. Our data suggested that dissociation of the AcrB trimer drastically decreased its interaction with AcrA. In addition, while substrate binding with AcrB seemed to be irrelevant to the presence or absence of AcrA and TolC, the capability of trimerization and conduction of proton influx did affect substrate binding at selected sites along the substrate translocation pathway in AcrB.

  4. Crystallisation mechanism of a multicomponent lithium alumino-silicate glass

    International Nuclear Information System (INIS)

    Wurth, R.; Pascual, M.J.; Mather, G.C.; Pablos-Martín, A.; Muñoz, F.; Durán, A.; Cuello, G.J.; Rüssel, C.

    2012-01-01

    A base glass of composition 3.5 Li 2 O∙0.15 Na 2 O∙0.2 K 2 O∙1.15 MgO∙0.8 BaO∙1.5 ZnO∙20 Al 2 O 3 ∙67.2 SiO 2 ∙2.6 TiO 2 ∙1.7 ZrO 2 ∙1.2 As 2 O 3 (in wt.%), melted and provided by SCHOTT AG (Mainz), was used to study the crystallisation mechanism of lithium alumino-silicate glass employing X-ray diffraction combined with neutron diffraction and non-isothermal differential scanning calorimetry (DSC). A high-quartz solid solution of LiAlSi 2 O 6 with nanoscaled crystals forms at 750 °C. Quantitative Rietveld refinement of samples annealed at 750 °C for 8 h determined a crystallised fraction of around 59 wt.%. The room temperature crystallised phase adopts an ordered, β-eucryptite-like structure (2 × 2 × 2 cell) with Li ordered in the structural channels. The Avrami parameter (n ∼ 4), calculated from DSC data using different theoretical approaches, indicates that bulk crystallisation occurs and that the number of nuclei increases during annealing. The activation energy of the crystallisation is 531 ± 20 kJ mol −1 . - Highlights: ► Nanoscaled high-quartz crystals from a multicomponent lithium alumino-silicate glass. ► Combined X-ray and neutron diffraction structural refinement. ► β-Eucryptite-like structure (2 × 2×2 cell) with Li ordered in the structural channels. ► 3-Dimensional bulk crystallisation mechanism with an increasing number of nuclei. ► Usage and validation of an alternative approach to calculate the Avrami parameter.

  5. Drug transport mechanism of the AcrB efflux pump.

    Science.gov (United States)

    Pos, Klaas M

    2009-05-01

    In Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, tripartite multidrug efflux systems extrude cytotoxic substances from the cell directly into the medium bypassing periplasm and the outer membrane. In E. coli, the tripartite efflux system AcrA/AcrB/TolC is the pump that extrudes multiple antibiotics, dyes, bile salts and detergents. The inner membrane component AcrB, a member of the Resistance Nodulation cell Division (RND) family, is the major site for substrate recognition and energy transduction of the entire tripartite system. The drug/proton antiport processes in this secondary transporter are suggested to be spatially separated, a feature frequently observed for primary transporters like membrane-bound ATPases. The recently elucidated asymmetric structure of the AcrB trimer reveals three different monomer conformations proposed to represent consecutive states in a directional transport cycle. Each monomer shows a distinct tunnel system with entrances located at the boundary of the outer leaflet of the inner membrane and the periplasm through the periplasmic porter (pore) domain towards the funnel of the trimer and TolC. In one monomer a hydrophobic pocket is present which has been shown to bind the AcrB substrates minocyclin and doxorubicin. The energy conversion from the proton motive force into drug efflux includes proton binding in (and release from) the transmembrane part. The conformational changes observed within a triad of essential, titratable residues (D407/D408/K940) residing in the hydrophobic transmembrane domain appear to be transduced by transmembrane helix 8 and associated with the conformational changes seen in the periplasmic domain. From the asymmetric structure a possible peristaltic pump transport mechanism based on a functional rotation of the AcrB trimer has been postulated. The novel drug transport model combines the alternate access pump mechanism with the rotating site catalysis of F(1)F(o) ATPase as

  6. Crystallisation mechanism of a multicomponent lithium alumino-silicate glass

    Energy Technology Data Exchange (ETDEWEB)

    Wurth, R. [Otto-Schott-Institut, Jena University, Fraunhoferstr. 6, 07743 Jena (Germany); Pascual, M.J., E-mail: mpascual@icv.csic.es [Instituto de Ceramica y Vidrio, CSIC, Kelsen 5, 28049 Madrid (Spain); Mather, G.C.; Pablos-Martin, A.; Munoz, F.; Duran, A. [Instituto de Ceramica y Vidrio, CSIC, Kelsen 5, 28049 Madrid (Spain); Cuello, G.J. [Institut Laue-Langevin, Boite Postale 156, 38042 Grenoble Cedex 9 (France); Ruessel, C. [Otto-Schott-Institut, Jena University, Fraunhoferstr. 6, 07743 Jena (Germany)

    2012-06-15

    A base glass of composition 3.5 Li{sub 2}O Bullet-Operator 0.15 Na{sub 2}O Bullet-Operator 0.2 K{sub 2}O Bullet-Operator 1.15 MgO Bullet-Operator 0.8 BaO Bullet-Operator 1.5 ZnO Bullet-Operator 20 Al{sub 2}O{sub 3} Bullet-Operator 67.2 SiO{sub 2} Bullet-Operator 2.6 TiO{sub 2} Bullet-Operator 1.7 ZrO{sub 2} Bullet-Operator 1.2 As{sub 2}O{sub 3} (in wt.%), melted and provided by SCHOTT AG (Mainz), was used to study the crystallisation mechanism of lithium alumino-silicate glass employing X-ray diffraction combined with neutron diffraction and non-isothermal differential scanning calorimetry (DSC). A high-quartz solid solution of LiAlSi{sub 2}O{sub 6} with nanoscaled crystals forms at 750 Degree-Sign C. Quantitative Rietveld refinement of samples annealed at 750 Degree-Sign C for 8 h determined a crystallised fraction of around 59 wt.%. The room temperature crystallised phase adopts an ordered, {beta}-eucryptite-like structure (2 Multiplication-Sign 2 Multiplication-Sign 2 cell) with Li ordered in the structural channels. The Avrami parameter (n {approx} 4), calculated from DSC data using different theoretical approaches, indicates that bulk crystallisation occurs and that the number of nuclei increases during annealing. The activation energy of the crystallisation is 531 {+-} 20 kJ mol{sup -1}. - Highlights: Black-Right-Pointing-Pointer Nanoscaled high-quartz crystals from a multicomponent lithium alumino-silicate glass. Black-Right-Pointing-Pointer Combined X-ray and neutron diffraction structural refinement. Black-Right-Pointing-Pointer {beta}-Eucryptite-like structure (2 Multiplication-Sign 2 Multiplication-Sign 2 cell) with Li ordered in the structural channels. Black-Right-Pointing-Pointer 3-Dimensional bulk crystallisation mechanism with an increasing number of nuclei. Black-Right-Pointing-Pointer Usage and validation of an alternative approach to calculate the Avrami parameter.

  7. Organisational learning is crystallised into artefacts

    DEFF Research Database (Denmark)

    Bertelsen, Olav Wedege

    1996-01-01

    In this note I understand organisational learning in terms of manifest crystallisation of collective experience into artefacts, and I attempt to integrate an engineering and an emancipatory perspective. A Danish music festival serves as an example.......In this note I understand organisational learning in terms of manifest crystallisation of collective experience into artefacts, and I attempt to integrate an engineering and an emancipatory perspective. A Danish music festival serves as an example....

  8. Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB

    Directory of Open Access Journals (Sweden)

    Beibei eWang

    2015-04-01

    Full Text Available The tripartite efflux pump assembly AcrAB-TolC is the major multidrug resistance transporter in E. coli. The inner membrane transporter AcrB is a homotrimer, energized by the proton movement down the transmembrane electrochemical gradient. The asymmetric crystal structures of AcrB with three monomers in distinct conformational states (access (A, binding (B and extrusion (E support a functional rotating mechanism, in which each monomer of AcrB cycles among the three states in a concerted way. However, the relationship between the conformational changes during functional rotation and drug translocation has not been totally understood. Here, we explored the conformational changes of the AcrB homotrimer during the ABE→BEA transition in different substrate-binding states using targeted MD simulations. It was found that the dissociation of substrate from the distal binding pocket of B monomer is closely related to the concerted conformational changes in the translocation pathway, especially the side chain reorientation of Phe628 and Tyr327. A second substrate binding at the proximal binding pocket of A monomer evidently accelerates the conformational transitions as well as substrate dissociation in B monomer. The acceleration effect of the multi-substrate binding mode provides a molecular explanation for the positive cooperativity observed in the kinetic studies of substrate efflux and deepens our understanding of the functional rotating mechanism of AcrB.

  9. Coarse-grained Simulations of Substrate Export through Multidrug Efflux Transporter AcrB

    Science.gov (United States)

    Jewel, Yead; Dutta, Prashanta; Liu, Jin

    2017-11-01

    The treatment of bacterial infectious diseases hampered by the overexpression of multidrug resistance (MDR) systems. The MDR system actively pumps the antibiotic drugs as well as other toxic compounds out of the cells. During the pumping, AcrB (one of the key MDR components) undergoes a series of large-scale proton/substrate dependent conformational changes. In this work, we implement a hybrid coarse-grained PACE force field that couples the united-atom protein model with the coarse-grained MARTINI water/lipid, to investigate the conformational changes of AcrB. We first develop the substrate force field which is compatible with PACE, then we implement the force field to explore large scale structural changes of AcrB in microsecond simulations. The effects of the substrate and the protonation states of two key residues: Asp407 and Asp408, are investigated. Our results show that the drug export through AcrB is proton as well as substrate dependent. Our simulations explain molecular mechanisms of substrate transport through AcrB complex, as well as provide valuable insights for designing proper antibiotic drugs. Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R01GM122081.

  10. Structures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate.

    Directory of Open Access Journals (Sweden)

    Abdessamad Ababou

    Full Text Available Gram-negative bacteria such as E. coli use tripartite efflux pumps such as AcrAB-TolC to expel antibiotics and noxious compounds. A key feature of the inner membrane transporter component, AcrB, is a short stretch of residues known as the gate/switch loop that divides the proximal and distal substrate binding pockets. Amino acid substitutions of the gate loop are known to decrease antibiotic resistance conferred by AcrB. Here we present two new AcrB gate loop variants, the first stripped of its bulky side chains, and a second in which the gate loop is removed entirely. By determining the crystal structures of the variant AcrB proteins in the presence and absence of erythromycin and assessing their ability to confer erythromycin tolerance, we demonstrate that the gate loop is important for AcrB export activity but is not required for erythromycin binding.

  11. Flow induced crystallisation of penetrable particles

    Science.gov (United States)

    Scacchi, Alberto; Brader, Joseph M.

    2018-03-01

    For a system of Brownian particles interacting via a soft exponential potential we investigate the interaction between equilibrium crystallisation and spatially varying shear flow. For thermodynamic state points within the liquid part of the phase diagram, but close to the crystallisation phase boundary, we observe that imposing a Poiseuille flow can induce nonequilibrium crystalline ordering in regions of low shear gradient. The physical mechanism responsible for this phenomenon is shear-induced particle migration, which causes particles to drift preferentially towards the center of the flow channel, thus increasing the local density in the channel center. The method employed is classical dynamical density functional theory.

  12. Water-assisted nitrogen mediated crystallisation of ZnO films

    Energy Technology Data Exchange (ETDEWEB)

    Muydinov, R. [Technical University Berlin, Institute of Semiconducting- and High-Frequency Technologies, Einsteinufer 25, 10587 Berlin (Germany); Steigert, A. [Helmholtz-Zentrum Berlin, Institute of Heterogeneous Material Systems, Albert-Einstein-Straße 15, 12489 Berlin (Germany); Schönau, S.; Ruske, F. [Helmholtz-Zentrum Berlin, Institute of Silicon Photovoltaics, Kekuléstraße 5, 12489 Berlin (Germany); Kraehnert, R.; Eckhardt, B. [Technical University Berlin, Institute of Technical Chemistry, Straße des 17. Juni 124, 10623 Berlin (Germany); Lauermann, I. [Helmholtz-Zentrum Berlin, Institute of Heterogeneous Material Systems, Albert-Einstein-Straße 15, 12489 Berlin (Germany); Szyszka, B. [Technical University Berlin, Institute of Semiconducting- and High-Frequency Technologies, Einsteinufer 25, 10587 Berlin (Germany)

    2015-09-01

    Nitrogen mediated crystallisation (NMC) being performed in oxygen atmosphere at T ≥ 600 °C is an effective approach to obtain very well (00l)-textured ZnO films. A use of NMC-seed layers remarkably improves electrical transport properties of subsequently deposited ZnO:Al contacts. In this work, crystallisation of quasi-amorphous, nitrogen doped ZnO seed layers has been performed using water vapours at overpressure and temperatures around 100 °C. This approach allows employment of soda-lime float-glass or temperature sensitive film stacks as a substrate. We propose here possible mechanism of water-assisted NMC and grope for optimised crystallisation conditions on the basis of optical, microscopic, and textural investigation. Low temperature water-assisted crystallisation of 20 nm thick ZnO layers was compared with high temperature annealing methods in terms of composition, microstructure and crystallinity. Electrical properties such as electron Hall mobility (μ{sub e}), concentration of free electrons (N{sub e}) and sheet resistance (R{sub sh}) have been evaluated and compared for functional ZnO:Al films obtained on glass and on differently crystallised NMC-seed layers. It was found that the crystallised with water assistance at low temperature ZnO seed layers provide comparable improvement in crystallinity and electrical properties of subsequently grown functional ZnO:Al films with respect to the ones crystallised at high temperature. Use of optimised water-assisted crystallisation of seed layers has allowed decreasing R{sub sh} of thin (130–270 nm) functional ZnO:Al films twice compared to the glass substrate. Both provide this effect: increase in μ{sub e} and increase of N{sub e}. - Highlights: • Amorphous ZnO:N films can be crystallised in autoclave at temperatures around 100 °C. • Such water-assisted crystallisation provides well-crystalline ZnO seed layers. • Use of these seed layers resulted in stress-free ZnO:Al contacts with twice lower R

  13. Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

    Directory of Open Access Journals (Sweden)

    Xuan Wang-Kan

    2017-07-01

    Full Text Available AcrAB-TolC is the paradigm resistance-nodulation-division (RND multidrug resistance efflux system in Gram-negative bacteria, with AcrB being the pump protein in this complex. We constructed a nonfunctional AcrB mutant by replacing D408, a highly conserved residue essential for proton translocation. Western blotting confirmed that the AcrB D408A mutant had the same native level of expression of AcrB as the parental strain. The mutant had no growth deficiencies in rich or minimal medium. However, compared with wild-type SL1344, the mutant had increased accumulation of Hoechst 33342 dye and decreased efflux of ethidium bromide and was multidrug hypersusceptible. The D408A mutant was attenuated in vivo in mouse and Galleria mellonella models and showed significantly reduced invasion into intestinal epithelial cells and macrophages in vitro. A dose-dependent inhibition of invasion was also observed when two different efflux pump inhibitors were added to the wild-type strain during infection of epithelial cells. RNA sequencing (RNA-seq revealed downregulation of bacterial factors necessary for infection, including those in the Salmonella pathogenicity islands 1, 2, and 4; quorum sensing genes; and phoPQ. Several general stress response genes were upregulated, probably due to retention of noxious molecules inside the bacterium. Unlike loss of AcrB protein, loss of efflux function did not induce overexpression of other RND efflux pumps. Our data suggest that gene deletion mutants are unsuitable for studying membrane transporters and, importantly, that inhibitors of AcrB efflux function will not induce expression of other RND pumps.

  14. Structural and functional aspects of the multidrug efflux pump AcrB.

    Science.gov (United States)

    Eicher, Thomas; Brandstätter, Lorenz; Pos, Klaas M

    2009-08-01

    The tripartite efflux system AcrA/AcrB/TolC is the main pump in Escherichia coli for the efflux of multiple antibiotics, dyes, bile salts and detergents. The inner membrane component AcrB is central to substrate recognition and energy transduction and acts as a proton/drug antiporter. Recent structural studies show that homotrimeric AcrB can adopt different monomer conformations representing consecutive states in an allosteric functional rotation transport cycle. The conformational changes create an alternate access drug transport tunnel including a hydrophobic substrate binding pocket in one of the cycle intermediates.

  15. Calcium silicate hydrate: Crystallisation and alkali sorption

    International Nuclear Information System (INIS)

    Hong, S.

    2000-01-01

    Homogeneous single C-S-H gels has been prepared for the investigation of alkali binding potential and crystallisation. A distribution coefficient, R d , was introduced to express the partition of alkali between solid and aqueous phases at 25 deg. C. R d is independent of alkali hydroxide concentration and depends only on Ca:Si ratio over wide ranges of alkali concentration. The trend of numerical values of R d indicates that alkali bonding into the solid improves as its Ca:Si ratio decreases. Reversibility is demonstrated, indicating a possibility of constant R d value of the material. Al has been introduced to form C-A-S-H gels and their alkali sorption properties also determined. Al substituted into C-S-H markedly increases R d , indicating enhancement of alkali binding. However, the dependence of R d on alkali concentration is non-ideal with composition. A two-site model for bonding is presented. Crystallisation both under saturated steam and 1 bar vapour pressure has been investigated. It has been shown that heat treatment by saturated steam causes crystallisation of gels. The principal minerals obtained were (i) C-S-H gel and Ca(OH) 2 at -55 deg. C, (ii) 1.1 nm tobermorite, jennite and afwillite at 85 -130 deg. C, and (iii) xonotlite, foshagite and hillebrandite at 150-180 deg. C. Properties of crystalline C-S-H were also reported for reversible phase transformation, pH conditioning ability, seeding effect and solubility. At 1 bar pressure, crystallisation is slower than in saturated steam due to lower water activity. Tobermorite-like nanodomains develop during reaction at low Ca/Si ratios. In some Ca-rich compositions, Ca(OH) 2 is exsolved and occurs as nano-sized crystallites. (author)

  16. Interaction between plate make and protein in protein crystallisation screening.

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    Gordon J King

    Full Text Available BACKGROUND: Protein crystallisation screening involves the parallel testing of large numbers of candidate conditions with the aim of identifying conditions suitable as a starting point for the production of diffraction quality crystals. Generally, condition screening is performed in 96-well plates. While previous studies have examined the effects of protein construct, protein purity, or crystallisation condition ingredients on protein crystallisation, few have examined the effect of the crystallisation plate. METHODOLOGY/PRINCIPAL FINDINGS: We performed a statistically rigorous examination of protein crystallisation, and evaluated interactions between crystallisation success and plate row/column, different plates of same make, different plate makes and different proteins. From our analysis of protein crystallisation, we found a significant interaction between plate make and the specific protein being crystallised. CONCLUSIONS/SIGNIFICANCE: Protein crystal structure determination is the principal method for determining protein structure but is limited by the need to produce crystals of the protein under study. Many important proteins are difficult to crystallize, so that identification of factors that assist crystallisation could open up the structure determination of these more challenging targets. Our findings suggest that protein crystallisation success may be improved by matching a protein with its optimal plate make.

  17. Crystallisation of glassy phases in nitride ceramics

    International Nuclear Information System (INIS)

    Ghaemi, S.; Swain, M.V.; Bell, T.J.

    1992-01-01

    The covalent nature of Si-N bond, as well as providing its chemical inertness, high hardness and strength, reduces its sinterability and inhibits production of fully dense Si 3 N 4 . Metal oxides are therefore added as sintering aids to achieve a fully dense body. They combine with the surface and present or added silica to form a low temperature liquid silicate. Liquid phase sintering occurs by a solution-precipitation mechanism, where the starting α-Si 3 N 4 powder dissolves in the liquid silicate and is precipitated as β-Si 3 N 4 . This liquid silicate solidifies, forming an amorphous grain boundary phase which degrades the high-temperature mechanical properties. Grain boundary sliding can be prevented and hence the high-temperature mechanical properties improved by increasing the softening point of the intergranular phase. This is done either by altering the glass composition to increase its softening point or by crystallizing the glass to a more refractory phase by post sinter heat treatment. In this study the latter technique is employed. The following results are reported. Addition of alumina increased the bulk density of samples in the Y-Si-O-N system. investigated. Increasing density was accompanied by improved mechanical properties. Crystallisation of amorphous phased improved the mechanical properties of various samples while hardness values increased with increasing annealing time. Microcracks caused by stresses induced as a result of glass crystallisation, can cause the failure of samples. Different specific volumes of crystallized materials can cause stresses that will eventually cause the material to fail. Complete crystallisation of glass in the materials investigated, resulted in increased density, hardness and toughness. 8 refs., 2 tabs., 5 figs

  18. Solid state crystallisation of oligosaccharide ester derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Elaine Ann

    2002-07-01

    An investigation of the solid state properties of oligosaccharide ester derivatives (OEDs) with potential applications in drug delivery has been carried out. The amorphous form of two OEDs, trehalose octa-acetate (TOAC) and 6:6'-di-({beta}-tetraacetyl glucuronyl)-hexaacetyl trehalose (TR153), was investigated as a matrix for the sustained release of active ingredients. The matrices showed a tendency to crystallise and so polymorph screens were performed to provide crystalline samples for structural analysis. The crystal structures of TOAC methanolate and TR153 acetonitrile solvate have been determined by single-crystal laboratory X-ray diffraction. TOAC methanolate crystallises in the orthorhombic space group P2{sub 1}2{sub 1}2{sub 1} with a = 15.429(18) A, b = 17.934(19) A and c = 13.518(4) A at 123 K. The structure is isomorphous with the previously reported structure of TOAC monohydrate form II. TR153 acetonitrile solvate crystallises in the monoclinic spacegroup C2 with a = 30:160(6) A, b = 11.878(3) A, c 20.6645(5) A and {beta} = 115.027 (10) deg at 123 K. The crystal structures of both TOAC methanolate and TR153 acetonitrile solvate are stabilised by complex networks of intermolecular C--H...O contacts. Two model compounds were selected for dissolution studies: diltiazem hydrochloride, as a water- soluble organic salt, and ketoprofen as a poorly water-soluble organic compound. Dissolution of both compounds from amorphous TOAC and TR153 matrices was investigated. The release of both drugs was more rapid and complete from TOAC matrices than from TR153 matrices, with both matrices showing a tendency to crystallise (devitrify) during the course of the dissolution experiments. This tendency was greater for the TOAC matrix, which transformed to the extent of ca. 100% within 48 hours. The available evidence suggests that devitrification of the matrix in contact with water produces a polycrystalline, non-monolithic structure rich in microscopic cracks and pores

  19. Solid state crystallisation of oligosaccharide ester derivatives

    International Nuclear Information System (INIS)

    Wright, Elaine Ann

    2002-01-01

    An investigation of the solid state properties of oligosaccharide ester derivatives (OEDs) with potential applications in drug delivery has been carried out. The amorphous form of two OEDs, trehalose octa-acetate (TOAC) and 6:6'-di-(β-tetraacetyl glucuronyl)-hexaacetyl trehalose (TR153), was investigated as a matrix for the sustained release of active ingredients. The matrices showed a tendency to crystallise and so polymorph screens were performed to provide crystalline samples for structural analysis. The crystal structures of TOAC methanolate and TR153 acetonitrile solvate have been determined by single-crystal laboratory X-ray diffraction. TOAC methanolate crystallises in the orthorhombic space group P2 1 2 1 2 1 with a = 15.429(18) A, b = 17.934(19) A and c = 13.518(4) A at 123 K. The structure is isomorphous with the previously reported structure of TOAC monohydrate form II. TR153 acetonitrile solvate crystallises in the monoclinic spacegroup C2 with a = 30:160(6) A, b = 11.878(3) A, c 20.6645(5) A and β = 115.027 (10) deg at 123 K. The crystal structures of both TOAC methanolate and TR153 acetonitrile solvate are stabilised by complex networks of intermolecular C--H...O contacts. Two model compounds were selected for dissolution studies: diltiazem hydrochloride, as a water- soluble organic salt, and ketoprofen as a poorly water-soluble organic compound. Dissolution of both compounds from amorphous TOAC and TR153 matrices was investigated. The release of both drugs was more rapid and complete from TOAC matrices than from TR153 matrices, with both matrices showing a tendency to crystallise (devitrify) during the course of the dissolution experiments. This tendency was greater for the TOAC matrix, which transformed to the extent of ca. 100% within 48 hours. The available evidence suggests that devitrification of the matrix in contact with water produces a polycrystalline, non-monolithic structure rich in microscopic cracks and pores which allows diffusion of

  20. Inhomogeneous bimolecular recombination in partially crystallised tri-methylphenyl diamine glasses

    International Nuclear Information System (INIS)

    Goldie, D.M.

    2013-01-01

    The rise and fall dynamics of transient photocurrents induced by exposure to ultraviolet radiation have been analysed for a series of glassy tri-methylphenyl diamine films that have been partially crystallised by ageing under ambient conditions following vapour deposition. An inhomogeneous bimolecular recombination model that uses coupled rate equations is found to provide a consistent fit for the observed photocurrent dynamics provided the recombination rate of holes in the crystallised regions of the films is lower compared to the amorphous regions. Parameters returned by the bimolecular model are investigated as a function of the film age but are observed to be highly sensitive to the initial experimental estimates that are supplied for the effective hole recombination time. The effective hole recombination time generated by the model is found to be relatively independent of film age, however, and has a value of around 0.16 s for a carrier generation rate of 7 × 10 14 cm −3 s −1 . The effective recombination time and steady-state photoconductivity magnitudes are found to be consistent with experimental hole mobility and photo-carrier generation efficiency values that are obtained using complementary time-of-flight and charge collection experiments. - Highlights: ► Transient photocurrents in evaporated diamine films have fast and slow components. ► Transient photocurrents are modelled using inhomogeneous bimolecular recombination. ► Recombination rates differ between crystallised and amorphous film regions. ► Recombination parameters evolve with film age as the films crystallise

  1. The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance.

    Science.gov (United States)

    Seeger, Markus A; Diederichs, Kay; Eicher, Thomas; Brandstätter, Lorenz; Schiefner, André; Verrey, François; Pos, Klaas M

    2008-09-01

    Antimicrobial resistance of human pathogenic bacteria is an emerging problem for global public health. This resistance is often associated with the overproduction of membrane transport proteins that are capable to pump chemotherapeutics, antibiotics, detergents, dyes and organic solvents out of the cell. In Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, tripartite multidrug efflux systems extrude a large variety of cytotoxic substances from the cell membrane directly into the medium bypassing the periplasm and the outer membrane. In E. coli, the tripartite efflux system AcrA/AcrB/TolC is the pump in charge of the efflux of multiple antibiotics, dyes, bile salts and detergents. The trimeric outer membrane factor (OMF) TolC forms a beta-barrel pore in the outer membrane and exhibits a long periplasmic alpha-helical conduit. The periplasmic membrane fusion protein (MFP) AcrA serves as a linker between TolC and the trimeric resistance nodulation cell division (RND) pump AcrB, located in the inner membrane acting as a proton/drug antiporter. The newly elucidated asymmetric structure of trimeric AcrB reveals three different monomer conformations representing consecutive states in a transport cycle. The monomers show tunnels with occlusions at different sites leading from the lateral side through the periplasmic porter (pore) domains towards the funnel of the trimer and TolC. The structural changes create a hydrophobic pocket in one monomer, which is not present in the other two monomers. Minocyclin and doxorubicin, both AcrB substrates, specifically bind to this pocket substantiating its role as drug binding pocket. The energy transduction from the proton motive force into drug efflux includes proton binding in (and release from) the transmembrane part. The conformational changes observed within a triad of essential, titratable residues (Asp407/Asp408/Lys940) residing in the hydrophobic transmembrane domain appear to be transduced by

  2. Crystallisation in water-in-cocoa butter emulsions: Role of the dispersed phase on fat crystallisation and polymorphic transition

    OpenAIRE

    Di Bari, Vincenzo; Macnaughtan, William; Norton, Jennifer; Sullo, Antonio; Norton, Ian

    2016-01-01

    The present work is one of the first to focus on the role of emulsified water droplets on the crystallisation behaviour of water-in-cocoa butter emulsions under quiescent conditions (i.e. absence of any externally applied force). Cocoa butter (CB) systems were designed to progressively increase the number of heterogeneous nuclei within the CB matrix, and the crystallisation behaviour was studied at four temperatures (5 °C, 10 °C, 15 °C and 20 °C). Information on the crystallisation kinetics a...

  3. Promoting crystallisation of the Salmonella enteritidis fimbriae 14 pilin SefD using deuterium oxide

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Bing; Garnett, James A.; Lee, Wei-chao; Lin, Jing; Salgado, Paula; Taylor, Jonathan; Xu, Yingqi; Lambert, Sebastian; Cota, Ernesto [Centre for Structural Biology and Division of Molecular Biosciences, Imperial College London, South Kensington, London SW7 2AZ (United Kingdom); Matthews, Steve, E-mail: s.j.matthews@imperial.ac.uk [Centre for Structural Biology and Division of Molecular Biosciences, Imperial College London, South Kensington, London SW7 2AZ (United Kingdom)

    2012-05-04

    Highlights: Black-Right-Pointing-Pointer The benefits of D{sub 2}O in screening for crystallisation was explored. Black-Right-Pointing-Pointer The crystal structures of the SefD pilin in both H{sub 2}O and D{sub 2}O reveal differences. Black-Right-Pointing-Pointer Crystallisation improvements are explained by altered interactions in D{sub 2}O crystals. Black-Right-Pointing-Pointer D{sub 2}O is useful additive in sparse-matrix screening for crystallisation. -- Abstract: The use of heavy water (D{sub 2}O) as a solvent is commonplace in many spectroscopic techniques for the study of biological macromolecules. A significant deuterium isotope effect exists where hydrogen-bonding is important, such as in protein stability, dynamics and assembly. Here we illustrate the use of D{sub 2}O in additive screening for the production of reproducible diffraction-quality crystals for the Salmonella enteritidis fimbriae 14 (SEF14) putative tip adhesin, SefD.

  4. Computational Study of Correlated Domain Motions in the AcrB Efflux Transporter

    Directory of Open Access Journals (Sweden)

    Robert Schulz

    2015-01-01

    Full Text Available As active part of the major efflux system in E. coli bacteria, AcrB is responsible for the uptake and pumping of toxic substrates from the periplasm toward the extracellular space. In combination with the channel protein TolC and membrane fusion protein AcrA, this efflux pump is able to help the bacterium to survive different kinds of noxious compounds. With the present study we intend to enhance the understanding of the interactions between the domains and monomers, for example, the transduction of mechanical energy from the transmembrane domain into the porter domain, correlated motions of different subdomains within monomers, and cooperative effects between monomers. To this end, targeted molecular dynamics simulations have been employed either steering the whole protein complex or specific parts thereof. By forcing only parts of the complex towards specific conformational states, the risk for transient artificial conformations during the simulations is reduced. Distinct cooperative effects between the monomers in AcrB have been observed. Possible allosteric couplings have been identified providing microscopic insights that might be exploited to design more efficient inhibitors of efflux systems.

  5. New insights into the structural and functional involvement of the gate loop in AcrB export activity.

    Science.gov (United States)

    Ababou, Abdessamad

    2018-02-01

    AcrB is a major multidrug exporter in Escherichia coli and other Gram-negative bacteria. Its gate loop, located between the proximal and the distal pockets, have been reported to play important role in the export of many antibiotics. This loop location, rigidity and interactions with substrates have led recent reports to suggest that AcrB export mechanism operates in a sequential manner. First the substrate binds the proximal pocket in the access monomer, then it moves to bind the distal pocket in the binding monomer and subsequently it is extruded in the extrusion monomer. Recently, we have demonstrated that the gate loop is not required for the binding of Erythromycin but the integrity of this loop is important for an efficient export of this substrate. However, here we show that the antibiotic susceptibilities of the same AcrB gate loop mutants for Doxorubicin were unaffected, suggesting that this loop is not required for its export, and we demonstrate that this substrate may use principally the tunnel-1, located between transmembranes 8 and 9, more often than previously reported. To further explain our findings, here we address the gate loop mutations effects on AcrB solution energetics (fold, stability, molecular dynamics) and on the in vivo efflux of Erythromycin and Doxorubicin. Finally, we discuss the efflux and the discrepancy between the structural and the functional experiments for Erythromycin in these gate loop mutants. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Calcium carbonate crystallisation at the microscopic level

    International Nuclear Information System (INIS)

    Dobson, Phillip Stephen

    2001-01-01

    The primary concern of this thesis is the investigation of crystal nucleation and growth processes, and the effect of foreign substrates on the rate, extent and mechanism of crystallisation, with particular emphasis on the calcium carbonate system. A methodology, based on the in-line mixing of two stable solutions, which permits the continuous delivery of a solution with a constant, known supersaturation, has been developed and characterised. This has been used to induce CaCO 3 crystallisation in experimental systems involving the channel flow and wall jet techniques. The channel flow method has been adapted to facilitate the study of crystal growth at a single calcite crystal. Ca 2+ ion selective electrodes have been employed as a means of monitoring depletion of the supersaturated solution, downstream of the crystal substrate. The data obtained suggested a growth rate constant of 3x10 -12 mol cm -2 s -1 (and a reaction order of 1.52 on supersaturation). The ex-situ techniques of optical microscopy and atomic force microscopy (AFM) were employed to visualise changes in the calcite surface topography resulting from exposure to the growth solution. A technique based on an impinging jet of supersaturated solution was developed and characterised as a method for inducing crystal growth on foreign substrates under defined hydrodynamic control. When used in conjunction with the ex-situ techniques of scanning electron microscopy (SEM), optical microscopy and micro-Raman spectroscopy, the role of substrate and supersaturation on the morphology and polymorphology of the CaCOs microcrystals was determined. The technique also proved to be a powerful tool for the evaluation of scale inhibiting surface coatings. The combination of the impinging jet method with thin transparent substrates allowed in-situ observation, through optical microscopy, of the induction and growth of CaCO 3 microcrystals on foreign substrates. A number of substrates, displaying various surface energies

  7. Structure development during isothermal crystallisation of high-density polyethylene: Synchrotron small-angle X-ray scattering study

    International Nuclear Information System (INIS)

    Ślusarczyk, Czesław

    2013-01-01

    Isothermal melt crystallisation in high-density polyethylene (HDPE) was studied using the time-resolved SAXS method with synchrotron radiation over a wide range of crystallisation temperatures. The SAXS profile was analysed by an interface distribution function, g 1 (r), which is a superposition of three contributions associated with the size distributions of crystalline (L C ) and amorphous (L A ) layers and a distribution of long period (LP). The morphological parameters extracted from the g 1 (r) functions show that the lamellar thickness increases with time, obeying a logarithmic time dependence. The time evolution of L C observed for the sample crystallised at 122 °C leads to the conclusion that crystallisation proceeds according to the mechanism of thickening growth. For samples crystallised at lower temperatures (116 °C and 118 °C), the lamellar thickening mechanism has been observed. The rate of lamellar thickening in these cases is much lower than that at 122 °C. At 40 °C, thickening of the crystalline layer does not occur. The interface distribution functions were deconvoluted, and the relative standard deviation σ C /L C obtained in this way is an additional parameter that is varied during crystallisation and can be used for analysis of this process. Time-dependent changes in the σ C /L C at large supercooling (T C =40 °C) indicates that L C presents a broad distribution in which the relative standard deviation increases with time. At lower supercooling (T C =122 °C), L C shows a much sharper distribution. In this case, the relative standard deviation decreases with time. - Highlights: • Isothermal melt crystallisation of high-density polyethylene (HDPE) was studied by time-resolved synchrotron small-angle X-ray scattering (SAXS) over a wide-range of supercoolings. • The SAXS profile was analysed by an interface distribution, g 1 (r), function. • At large supercooling (40 °C) the thickening of the crystalline layer does not occur. At

  8. Crystallisation of mixtures of ammonium nitrate, ammonium sulphate and soot

    NARCIS (Netherlands)

    Dougle, P.G.; Veefkind, J.P.; Brink, H.M. ten

    1998-01-01

    Crystallisation of laboratory aerosols of ammonium nitrate and of internal mixtures of this salt with ammonium sulphate were investigated using humidity controlled nephelometry. The aerosol was produced via nebulizing of solutions and then dried to 25% RH, which is a realistic minimum value for

  9. Simulation of the reextraction-crystallisation of uranium

    International Nuclear Information System (INIS)

    Mehablia, M.A.

    1990-01-01

    This paper deals with computer simulation of the reextraction-crystallisation of A.U.C by ammonium carbonate from an organic solution using the extended NRTL model for an electrolytic system. The effect of temperature and extractant concentration was studied [fr

  10. Model of the Alphinising Coating Crystallisation on Iron Alloys

    Directory of Open Access Journals (Sweden)

    S. Pietrowski

    2007-07-01

    Full Text Available The study presents a hypothetical model of crystallisation of the alphinising coating produced on iron alloys by immersion in the bath of silumin. Basing on a wide-range of experiments and investigations, the effect of the type of inserted material (“armco” iron, C45 steel, grey cast iron and nodular graphite cast iron and of the technological regime of the alphinising process (chemical composition of silumin bath, its temperature, the time of holding an insert in the bath, and the insert surface roughness height “Rz” on the coating structure was determined. The type of the coating structure was established by metallographic examinations carried out by optical microscopy, electron transmission microsopy and scanning electron microscopy, using additionally an X-ray microanalyser and X-ray diffraction patterns. The results of these investigations were described in [1÷7]. Basing on the obtained results, a probable model of the crystallisation of an alphi-nising coating on iron alloys, produced by immersion in the alphinising bath, was developed. It has been stated that, most probably, the alphinising process begins when the insert reaches its contact temperature “ts”.. Since that moment, due to the wetting process and convec-tion movement of bath around the insert surface, an intense process of the dissolution starts. A reactive diffusion of the atoms of Fe and Si from the insert to the bath and of the atoms of Al and Si from the bath to the insert takes place. An intermetallic Al3Fe phase is crystallis-ing on the steel, while on the cast iron, a silicon carbide Fe4CSi is growing, probably due to carbon diffusion from graphite. Then, on the steel, as an effect of the peritectic reaction, are successively crystallising the phases of Al12Fe3Si2 and Al9Fe3Si2. The Al3Fe phase probably crystallises on the cast iron to be transformed later, due to peritectic reaction, into an Al12Fe3Si2 phase on which the Al9Fe3Si2 phase will be growing

  11. Repressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB

    Directory of Open Access Journals (Sweden)

    Zhaoshuai eWang

    2015-01-01

    Full Text Available AcrAB-TolC and their homologs are major multidrug efflux systems in Gram-negative bacteria. The inner membrane component AcrB functions as a trimer. Replacement of Pro223 by Gly in AcrB decreases the trimer stability and drastically reduces the drug efflux activity. The goal of this study is to identify suppressor mutations that restore function to mutant AcrBP223G and explore the mechanism of function recovery. Two methods were used to introduce random mutations into the plasmid of AcrBP223G. Mutants with elevated drug efflux activity were identified, purified, and characterized to examine their expression level, trimer stability, interaction with AcrA, and substrate binding. Nine single-site repressor mutations were identified, including T199M, D256N, A209V, G257V, M662I, Q737L, D788K, P800S, and E810K. Except for M662I, all other mutations located in the docking region of the periplasmic domain. While three mutations, T199M, A209V, and D256N, significantly increased the trimer stability, none of them restored the trimer affinity to the wild type level. M662, the only site of mutation that located in the porter domain, was involved in substrate binding. Our results suggest that the function loss resulted from compromised AcrB trimerization could be restored through various mechanisms involving the compensation of trimer stability and substrate binding.

  12. A study of the structure and crystallisation of nanocrystalline zirconia

    International Nuclear Information System (INIS)

    Tucker, M.

    1999-12-01

    Nanocrystalline zirconia, prepared via, calcination of the hydroxide, has been studied using a variety of experimental techniques. Two chemical routes, a precipitation and a sol-gel route, were used to prepare the hydroxide. Neutron and X-ray diffraction, EXAFS, NMR and SANS have been used to study the structure and crystallisation, during in-situ and ambient condition measurements. The structural information from the diffraction data has been complimented by the other techniques to provide information on the short, medium and longer range structure of nanocrystalline zirconia. Pure and yttrium doped samples were studied, this enabled the affects of doping and preparation routes to be investigated. The amorphous hydroxide was found to have a, monoclinic-like structure for all samples, independent of preparation route or yttrium content. The crystallisation temperature was lowest for the pure precipitation sample and was increased by the addition of yttrium or by preparation via, the sol-gel route. For the precipitation samples, in addition to the crystallisation temperature being raised, doping with yttrium also had an effect on the size of the crystallites obtained at high temperatures. Due to the different incorporation method of the yttrium into the sol-gel samples the effect on crystallite size and crystallisation temperature, as seen for the precipitation samples, were not evident for the sol-gel samples. The neutron and NMR data clearly show hydrogen remains in the samples well after crystallisation has become evident. The structural picture of nanocrystalline zirconia consisting of small crystallites surrounded by material containing, or terminated by, hydroxyl groups, is supported by all the results and methods used in this thesis. The in-situ and ambient conditions data is combined into a coherent growth picture of the nanocrystalline material from the hydroxide until at high enough temperatures the bulk or polycrystalline material is formed. (author)

  13. Epitaxially grown polycrystalline silicon thin-film solar cells on solid-phase crystallised seed layers

    Energy Technology Data Exchange (ETDEWEB)

    Li, Wei, E-mail: weili.unsw@gmail.com; Varlamov, Sergey; Xue, Chaowei

    2014-09-30

    Highlights: • Crystallisation kinetic is used to analyse seed layer surface cleanliness. • Simplified RCA cleaning for the seed layer can shorten the epitaxy annealing duration. • RTA for the seed layer can improve the quality for both seed layer and epi-layer. • Epitaxial poly-Si solar cell performance is improved by RTA treated seed layer. - Abstract: This paper presents the fabrication of poly-Si thin film solar cells on glass substrates using seed layer approach. The solid-phase crystallised P-doped seed layer is not only used as the crystalline template for the epitaxial growth but also as the emitter for the solar cell structure. This paper investigates two important factors, surface cleaning and intragrain defects elimination for the seed layer, which can greatly influence the epitaxial grown solar cell performance. Shorter incubation and crystallisation time is observed using a simplified RCA cleaning than the other two wet chemical cleaning methods, indicating a cleaner seed layer surface is achieved. Cross sectional transmission microscope images confirm a crystallographic transferal of information from the simplified RCA cleaned seed layer into the epi-layer. RTA for the SPC seed layer can effectively eliminate the intragrain defects in the seed layer and improve structural quality of both of the seed layer and the epi-layer. Consequently, epitaxial grown poly-Si solar cell on the RTA treated seed layer shows better solar cell efficiency, V{sub oc} and J{sub sc} than the one on the seed layer without RTA treatment.

  14. Switch loop flexibility affects substrate transport of the AcrB efflux pump

    International Nuclear Information System (INIS)

    Muller, Reinke T.; Travers, Timothy; Cha, Hi-jea; Phillips, Joshua L.

    2017-01-01

    The functionally important switch-loop of the trimeric multidrug transporter AcrB separates the access and deep drug binding pockets in every protomer. This loop, comprising 11 amino acid residues, has been shown to be crucial for substrate transport, as drugs have to travel past the loop to reach the deep binding pocket and from there are transported outside the cell via the connected AcrA and TolC channels. It contains four symmetrically arranged glycine residues suggesting that flexibility is a key feature for pump activity. Upon combinatorial substitution of these glycine residues to proline, functional and structural asymmetry was observed. Proline substitutions on the PC1 proximal side completely abolished transport and reduced backbone flexibility of the switch loop, which adopted a conformation restricting the pathway towards the deep binding pocket. Here, two phenylalanine residues located adjacent to the substitution sensitive glycine residues play a role in blocking the pathway upon rigidification of the loop, since the removal of the phenyl rings from the rigid loop restores drug transport activity.

  15. Oxidation influence on crystallisation in iron-based amorphous alloys

    Energy Technology Data Exchange (ETDEWEB)

    Gloriant, T.; Surinach, S.; Munoz, J.S.; Baro, M.D. [Universitat Autonoma de Barcelona (Spain). Dept. de Fisica; Inoue, A. [Tohoku Univ., Sendai (Japan). Inst. for Materials Research

    2001-07-01

    The partially crystalline iron-based nanophase composites elaborated by rapid solidification techniques are very attractive for their excellent soft magnetic properties and their potential for industrial applications. In these nanocomposite materials a control of both the structure (size, shape and distribution of the nanoparticles in the amorphous matrix) and the kinetic behaviour (nucleation and growth mechanism) is essential in order to obtain the best properties and to be able to produce them at the industrial scale. Our group has been working in this research area for a long time and the investigation presented here is the result of an international collaboration. This study deals with the effect of cobalt addition in Fe-Nb-B melt-spun amorphous alloys on the devitrification/crystallisation processes induced by thermal treatments and characterised by X-ray diffraction analysis (XRD), thermomagnetic analysis (TMG) and transmission electron microscopy observations (TEM). The transformation sequences, from the initial amorphous phase to the fully crystallised final state, were carried out using different annealing experiments (under vacuum and in air) and have revealed a strong influence of the environmental atmosphere during devitrification. It is shown that oxidation can greatly affect the crystallisation behaviour as a result of the high metastable state of the initial amorphous phase. The results and observations of this phenomenon will be presented. (orig.)

  16. AEB highlights

    International Nuclear Information System (INIS)

    1975-01-01

    AEB HIGHLIGHTS is a half-yearly report reflecting the most important recent achievements of the various Research and Technical Divisions of the Atomic Energy Board. It appears alternately in English and Afrikaans [af

  17. BBG Highlights

    Data.gov (United States)

    Broadcasting Board of Governors — BBG Highlights is a monthly summary of the BBG's accomplishments and news and developments affecting the Agency's work. Now, for the first time, this monthly update...

  18. AEB highlights

    International Nuclear Information System (INIS)

    1977-01-01

    AEB HIGHLIGHTS is a half yearly report reflecting the most important recent achievements of the various Research and Technical Divisions of the Atomic Energy Board. It appears alternately in English and Afrikaans [af

  19. Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB.

    Science.gov (United States)

    Eicher, Thomas; Seeger, Markus A; Anselmi, Claudio; Zhou, Wenchang; Brandstätter, Lorenz; Verrey, François; Diederichs, Kay; Faraldo-Gómez, José D; Pos, Klaas M

    2014-09-19

    Membrane transporters of the RND superfamily confer multidrug resistance to pathogenic bacteria, and are essential for cholesterol metabolism and embryonic development in humans. We use high-resolution X-ray crystallography and computational methods to delineate the mechanism of the homotrimeric RND-type proton/drug antiporter AcrB, the active component of the major efflux system AcrAB-TolC in Escherichia coli, and one most complex and intriguing membrane transporters known to date. Analysis of wildtype AcrB and four functionally-inactive variants reveals an unprecedented mechanism that involves two remote alternating-access conformational cycles within each protomer, namely one for protons in the transmembrane region and another for drugs in the periplasmic domain, 50 Å apart. Each of these cycles entails two distinct types of collective motions of two structural repeats, coupled by flanking α-helices that project from the membrane. Moreover, we rationalize how the cross-talk among protomers across the trimerization interface might lead to a more kinetically efficient efflux system.

  20. Solid phase crystallisation of HfO2 thin films

    International Nuclear Information System (INIS)

    Modreanu, M.; Sancho-Parramon, J.; O'Connell, D.; Justice, J.; Durand, O.; Servet, B.

    2005-01-01

    In this paper, we report on the solid phase crystallisation of carbon-free HfO 2 thin films deposited by plasma ion assisted deposition (PIAD). After deposition, the HfO 2 films were annealed in N 2 ambient for 3 h at 350, 550 and 750 deg. C. Several characterisation techniques including X-ray reflectometry (XRR), X-ray diffraction (XRD), spectroscopic ellipsometry (SE) and atomic force microscopy (AFM) were used for the physical characterisation of as-deposited and annealed HfO 2 . XRD has revealed that the as-deposited HfO 2 film is in an amorphous-like state with only traces of crystalline phase and that the annealed films are in a highly crystalline state. These results are in good agreement with the SE results showing an increase of refractive index by increasing the annealing temperature. XRR results show a significant density gradient over the as-deposited film thickness, which is characteristic of the PIAD method. The AFM measurements show that the HfO 2 layers have a smooth surface even after annealing at 750 deg. C. The present study demonstrates that the solid phase crystallisation of HfO 2 PIAD thin films starts at a temperature as low as 550 deg. C

  1. Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance.

    Science.gov (United States)

    Wang, Yinhu; Mowla, Rumana; Guo, Liwei; Ogunniyi, Abiodun D; Rahman, Taufiq; De Barros Lopes, Miguel A; Ma, Shutao; Venter, Henrietta

    2017-02-15

    Drug efflux pumps confer multidrug resistance to dangerous pathogens which makes these pumps important drug targets. We have synthesised a novel series of compounds based on a 2-naphthamide pharmacore aimed at inhibiting the efflux pumps from Gram-negative bacteria. The archeatypical transporter AcrB from Escherichia coli was used as model efflux pump as AcrB is widely conserved throughout Gram-negative organisms. The compounds were tested for their antibacterial action, ability to potentiate the action of antibiotics and for their ability to inhibit Nile Red efflux by AcrB. None of the compounds were antimicrobial against E. coli wild type cells. Most of the compounds were able to inhibit Nile Red efflux indicating that they are substrates of the AcrB efflux pump. Three compounds were able to synergise with antibiotics and reverse resistance in the resistant phenotype. Compound A3, 4-(isopentyloxy)-2-naphthamide, reduced the MICs of erythromycin and chloramphenicol to the MIC levels of the drug sensitive strain that lacks an efflux pump. A3 had no effect on the MIC of the non-substrate rifampicin indicating that this compound acts specifically through the AcrB efflux pump. A3 also does not act through non-specific mechanisms such as outer membrane or inner membrane permeabilisation and is not cytotoxic against mammalian cell lines. Therefore, we have designed and synthesised a novel chemical compound with great potential to further optimisation as inhibitor of drug efflux pumps. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Brookhaven highlights

    International Nuclear Information System (INIS)

    Rowe, M.S.; Belford, M.; Cohen, A.; Greenberg, D.; Seubert, L.

    1993-01-01

    This report highlights the research activities of Brookhaven National Laboratory during the period dating from October 1, 1992 through September 30, 1993. There are contributions to the report from different programs and departments within the laboratory. These include technology transfer, RHIC, Alternating Gradient Synchrotron, physics, biology, national synchrotron light source, applied science, medical science, advanced technology, chemistry, reactor physics, safety and environmental protection, instrumentation, and computing and communications

  3. Symposium Highlights

    International Nuclear Information System (INIS)

    Owen-Whitred, K.

    2015-01-01

    Overview/Highlights: To begin, I'd like to take a moment to highlight some of the novel elements of this Symposium as compared to those that have been held in the past. For the first time ever, this Symposium was organized around five concurrent sessions, covering over 300 papers and presentations. These sessions were complemented by an active series of exhibits put on by vendors, universities, ESARDA, INMM, and Member State Support Programmes. We also had live demonstrations throughout the week on everything from software to destructive analysis to instrumentation, which provided the participants the opportunity to see recent developments that are ready for implementation. I'm sure you all had a chance to observe - and, more importantly, interact with - the electronic Poster, or ePoster format used this past week. This technology was used here for the first time ever by the IAEA, and I'm sure was a first for many of us as well. The ePoster format allowed participants to interact with the subject matter, and the subject matter experts, in a dynamic, engaging way. In addition to the novel technology used here, I have to say that having the posters strategically embedded in the sessions on the same topic, by having each poster author introduce his or her topic to the assembled group in order to lure us to the poster area during the breaks, was also a novel and highly effective technique. A final highlight I'd like to touch on in terms of the Symposium organization is the diversity of participation. This chart shows the breakdown by geographical distribution for the Symposium, in terms of participants. There are no labels, so don't try to read any, I simply wanted to demonstrate that we had great representation in terms of both the Symposium participants in general and the session chairs more specifically-and on that note, I would just mention here that 59 Member States participated in the Symposium. But what I find especially interesting and

  4. Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter.

    Science.gov (United States)

    Cha, Hi-jea; Müller, Reinke T; Pos, Klaas M

    2014-08-01

    Multidrug efflux transporters recognize a variety of structurally unrelated compounds for which the molecular basis is poorly understood. For the resistance nodulation and cell division (RND) inner membrane component AcrB of the AcrAB-TolC multidrug efflux system from Escherichia coli, drug binding occurs at the access and deep binding pockets. These two binding areas are separated by an 11-amino-acid-residue-containing switch loop whose conformational flexibility is speculated to be essential for drug binding and transport. A G616N substitution in the switch loop has a distinct and local effect on the orientation of the loop and on the ability to transport larger drugs. Here, we report a distinct phenotypical pattern of drug recognition and transport for the G616N variant, indicating that drug substrates with minimal projection areas of >70 Å(2) are less well transported than other substrates. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  5. Crystallisation of hydroxyapatite in phosphorylated poly(vinyl alcohol) as a synthetic route to tough mechanical hybrid materials

    Energy Technology Data Exchange (ETDEWEB)

    Kusakabe, Akane; Hirota, Ken; Mizutani, Tadashi, E-mail: tmizutan@mail.doshisha.ac.jp

    2017-01-01

    Partially phosphorylated poly(vinyl alcohol) was prepared by treating poly(vinyl alcohol) with 100% phosphoric acid, and 5, 10 and 20% of the hydroxyl groups were converted to phosphoric acid ester. Addition of Ca{sup 2+} to an aqueous solution of phosphorylated poly(vinyl alcohol) gave a transparent gel. Five cycles of alternate soaking of the gel in aqueous CaCl{sub 2} and aqueous (NH{sub 4}){sub 2}HPO{sub 4} were carried out to crystallise hydroxyapatite (HAP) in the phosphorylated poly(vinyl alcohol) matrix. The X-ray diffraction peaks of HAP formed in 5% phosphorylated PVA were sharp, while those of HAP formed in 20% phosphorylated PVA were broad. The contents of inorganic phase in the hybrid powder were increased from 58 to 76 wt% as the fraction of phosphate groups in the gel was decreased from 20% to 5%. The hybrid powder was first subjected to uniaxial pressing, followed by cold isostatic pressing (CIP) and warm isostatic pressing (WIP) at 120 °C at pressures of 300–980 MPa, to obtain the specimens for three-point bending test. These hybrid specimens showed bending strengths of 15–53 MPa. The hybrid compacts prepared from 10% phosphorylated poly(vinyl alcohol) showed the smallest Young's modulus, the largest displacement at break, and the largest fracture energy, showing that it has the highest toughness among the hybrid materials prepared from poly(vinyl alcohol) with varying degrees of phosphorylation. - Graphical abstract: Densification of hydroxyapatite crystallised in 10% phosphorylated poly(vinyl alcohol) gave the toughest compact. - Highlights: • Hydroxyapatite was crystallised in phosphorylated poly(vinyl alcohol) gels. • Crystallite size of hydroxyapatite decreased as phosphate density was increased. • The hybrid specimens prepared in 10% phosphorylated gel was the toughest. • Phosphate density in organic matrix regulated the mechanical properties of the hybrid.

  6. Crystallisation of hydroxyapatite in phosphorylated poly(vinyl alcohol) as a synthetic route to tough mechanical hybrid materials

    International Nuclear Information System (INIS)

    Kusakabe, Akane; Hirota, Ken; Mizutani, Tadashi

    2017-01-01

    Partially phosphorylated poly(vinyl alcohol) was prepared by treating poly(vinyl alcohol) with 100% phosphoric acid, and 5, 10 and 20% of the hydroxyl groups were converted to phosphoric acid ester. Addition of Ca 2+ to an aqueous solution of phosphorylated poly(vinyl alcohol) gave a transparent gel. Five cycles of alternate soaking of the gel in aqueous CaCl 2 and aqueous (NH 4 ) 2 HPO 4 were carried out to crystallise hydroxyapatite (HAP) in the phosphorylated poly(vinyl alcohol) matrix. The X-ray diffraction peaks of HAP formed in 5% phosphorylated PVA were sharp, while those of HAP formed in 20% phosphorylated PVA were broad. The contents of inorganic phase in the hybrid powder were increased from 58 to 76 wt% as the fraction of phosphate groups in the gel was decreased from 20% to 5%. The hybrid powder was first subjected to uniaxial pressing, followed by cold isostatic pressing (CIP) and warm isostatic pressing (WIP) at 120 °C at pressures of 300–980 MPa, to obtain the specimens for three-point bending test. These hybrid specimens showed bending strengths of 15–53 MPa. The hybrid compacts prepared from 10% phosphorylated poly(vinyl alcohol) showed the smallest Young's modulus, the largest displacement at break, and the largest fracture energy, showing that it has the highest toughness among the hybrid materials prepared from poly(vinyl alcohol) with varying degrees of phosphorylation. - Graphical abstract: Densification of hydroxyapatite crystallised in 10% phosphorylated poly(vinyl alcohol) gave the toughest compact. - Highlights: • Hydroxyapatite was crystallised in phosphorylated poly(vinyl alcohol) gels. • Crystallite size of hydroxyapatite decreased as phosphate density was increased. • The hybrid specimens prepared in 10% phosphorylated gel was the toughest. • Phosphate density in organic matrix regulated the mechanical properties of the hybrid.

  7. The application of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the stratum corneum.

    Science.gov (United States)

    Goh, Choon Fu; Craig, Duncan Q M; Hadgraft, Jonathan; Lane, Majella E

    2017-02-01

    Drug permeation through the intercellular lipids, which pack around and between corneocytes, may be enhanced by increasing the thermodynamic activity of the active in a formulation. However, this may also result in unwanted drug crystallisation on and in the skin. In this work, we explore the combination of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the skin. Ex vivo permeation studies of saturated solutions of diclofenac sodium (DF Na) in two vehicles, propylene glycol (PG) and dimethyl sulphoxide (DMSO), were carried out in porcine ear skin. Tape stripping and ATR-FTIR spectroscopy were conducted simultaneously to collect spectral data as a function of skin depth. Multivariate data analysis was applied to visualise and categorise the spectral data in the region of interest (1700-1500cm -1 ) containing the carboxylate (COO - ) asymmetric stretching vibrations of DF Na. Spectral data showed the redshifts of the COO - asymmetric stretching vibrations for DF Na in the solution compared with solid drug. Similar shifts were evident following application of saturated solutions of DF Na to porcine skin samples. Multivariate data analysis categorised the spectral data based on the spectral differences and drug crystallisation was found to be confined to the upper layers of the skin. This proof-of-concept study highlights the utility of ATR-FTIR spectroscopy in combination with multivariate data analysis as a simple and rapid approach in the investigation of drug deposition in the skin. The approach described here will be extended to the study of other actives for topical application to the skin. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Crystallisation and chain conformation of long chain n-alkanes

    International Nuclear Information System (INIS)

    Gorce, J.

    2000-06-01

    Hydrocarbon chains are a basic component in a number of systems as diverse as biological membranes, phospholipids and polymers. A better understanding of the physical properties of n-alkane chains should provide a better understanding of these more complex systems. With this aim, vibrational spectroscopy has been extensively used. This technique, sensitive to molecular details, is the only one able to both identify and quantify conformational disorder present in paraffinic systems. To achieve this, methyl deformations have been widely used as ''internal standards'' for the normalisation of peak areas. However, in the case of n-alkanes with short chain length, such as n-C 44 H 90 for example, the infrared spectra recorded at liquid nitrogen temperature and reported here show the sensitivity of these latter peaks to the various crystal structures formed. Indeed, the main frequencies of the symmetric methyl bending mode were found between 1384 cm -1 and 1368 cm -1 as a function of the crystal form. Changes in the frequency of the first order of the L.A.M. present in the Raman spectra were also observed. At higher temperatures, non all-trans conformers, inferred from different infrared bands present in the wagging mode region, were found to be essentially placed at the end of the n-alkane chains. At the monoclinic phase transition, the concentration of end-gauche conformers, proportional to the area of the infrared band at 1342 cm -1 , increases abruptly. On the contrary, in the spectra recorded at liquid nitrogen temperature no such band is observed. We also studied the degree of disorder in two purely monodisperse long chain n-alkanes, namely n-C 198 H 398 and n-C 246 H 494 . The chain conformation as well as the tilt angle of the chains from the crystal surfaces were determined by means of low frequency Raman spectroscopy and S.A.X.S. measurements on solution-crystallised samples. The increase in the number of end-gauche conformers which was expected to occur with

  9. Effect of Crystallisation Degree on Hardness of Basaltic Glass-Ceramics

    DEFF Research Database (Denmark)

    Jensen, Martin; Smedskjær, Morten Mattrup; Yue, Yuanzheng

    The dependence of hardness of basaltic glass-ceramics on their crystallisation degree has been explored by means of differential scanning calorimetry, optical microscopy, X-ray diffraction, and Vickers indentation. Different degrees of crystallisation in the basaltic glasses have been obtained...... by varying the temperature of heat treatment. The change of the relative degree of crystallisation with the heat treatment temperature can be described by an empirical model established in this work. The predominant crystalline phase in the glass has been identified as the pyroxene augite. The hardness...... principle calculations. It is found that the hardness of the glass phase decreases slightly with an increase in the degree of crystallisation, while that of the augite phase drastically decreases....

  10. Effects of emulsion droplet sizes on the crystallisation of milk fat.

    Science.gov (United States)

    Truong, Tuyen; Bansal, Nidhi; Sharma, Ranjan; Palmer, Martin; Bhandari, Bhesh

    2014-02-15

    The crystallisation properties of milk fat emulsions containing dairy-based ingredients as functions of emulsion droplet size, cooling rate, and emulsifier type were investigated using a differential scanning calorimeter (DSC). Anhydrous milk fat and its fractions (stearin and olein) were emulsified with whey protein concentrate, sodium caseinate, and Tween80 by homogenisation to produce emulsions in various size ranges (0.13-3.10 μm). Particle size, cooling rate, and types of emulsifier all had an influence on the crystallisation properties of fat in the emulsions. In general, the crystallisation temperature of emulsified fats decreased with decreasing average droplet size and was of an exponent function of size, indicating that the influence of particle size on crystallisation temperature is more pronounced in the sub-micron range. This particle size effect was also verified by electron microscopy. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labeling.

    Science.gov (United States)

    Seeger, Markus A; von Ballmoos, Christoph; Verrey, François; Pos, Klaas M

    2009-06-30

    The three-component AcrA/AcrB/TolC efflux system of Escherichia coli catalyzes the proton motive force-driven extrusion of a variety of cytotoxic compounds. The inner membrane pump component AcrB belongs to the resistance nodulation and cell division (RND) superfamily and is responsible for drug specificity and energy transduction of the entire tripartite efflux system. Systematic mutational analysis of titratable and polar membrane-located amino acids revealed four residues, D407, D408, K940, and, R971, to be of prime importance for AcrB function. Using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry, D408 was shown to specifically react with dicyclohexylcarbodiimide (DCCD) in a pH-dependent manner. The apparent pK(a) of D408 of 7.4 would enable binding and release of protons under physiological conditions. In contrast to other secondary transporters, D408 was not protected from carbodiimide modification in the presence of drugs, which supports the notion of spatially separated transport pathways for drugs and protons. This study provides evidence for a substantial role of membrane-located carboxylates as a central element of the proton translocation pathway in AcrB and other members of the RND superfamily.

  12. The Prevalence of acrA and acrB Genes Among Multiple-Drug Resistant Uropathogenic Escherichia coli Isolated From Patients With UTI in Milad Hospital, Tehran

    Directory of Open Access Journals (Sweden)

    Maleki

    2016-09-01

    Full Text Available Background Urinary tract infection (UTI is one of the most common infectious diseases and nosocomial infections worldwide, and uropathogenic Escherichia coli is the primary cause of UTI. Due to increased antibiotic resistance and the emergence of multidrug resistant (MDR UPEC clones, the treatment of UTI is difficult. The occurrence of MDR in E. coli has been attributed to the AcrAB-TolC complex of efflux pumps. Objectives The aim of this study was to complete a frequency evaluation of acrA and acrB genes among UPEC MDR strains isolated from patients with UTI who were admitted to Milad hospital in Tehran. Methods For 123 UPEC strains that were isolated and diagnosed from the urine samples of patients using biochemical tests, antibiotic susceptibility was carried out using the disc diffusion method according to CLSI guidelines. Isolates that were resistant to at least one antimicrobial agent in three or more of the categories were considered to be MDR. The presence and frequency of acrA and acrB genes was determined using PCR. Results The rates of antibiotic resistance to ampicillin, cefalotin, tetracycline, cefazolin, ceftriaxone, ceftizoxime, ceftazidime, ciprofloxacin, and cotrimoxazole were 82.9%, 78.1%, 61.1%, 49.5%, 38.2%, 30.2%, 26.1%, 42.2%, and 60.1%, respectively. The isolates were most sensitive to nitrofurantoin (95.9%, gentamicin (77.2%, and amikacin (71.5%. A total of 78% of the isolates were MDR. The frequency of the acrA gene was 82.90%, the acrB gene was 95.90% and acrA + acrB was 95.90%. There was no significant difference between acrA and acrB frequency relating to bacterial antibiotic resistance. Conclusions Our results showed that ways to control the treatment of UTI for the prevention of MDR occurrence should be sought. For a better study of efflux pumps, a comprehensive and detailed study regarding the presence of efflux pumps gees is required.

  13. Influence of ZnO/MgO substitution on sintering, crystallisation, and bio-activity of alkali-free glass-ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Kapoor, Saurabh [Department of Materials and Ceramics Engineering, University of Aveiro, CICECO, 3810-193 Aveiro (Portugal); Goel, Ashutosh [Department of Materials Science and Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8065 (United States); Correia, Ana Filipa [Department of Materials and Ceramics Engineering, University of Aveiro, CICECO, 3810-193 Aveiro (Portugal); Pascual, Maria J. [Instituto de Cerámica y Vidrio (CSIC), Kelsen 5, Campus de Cantoblanco, 28049 Madrid (Spain); Lee, Hye-Young; Kim, Hae-Won [Institute of Tissue Regeneration Engineering (ITREN) & College of Dentistry, Dankook University, Cheonan 330714 (Korea, Republic of); Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Centre for Regenerative Medicine, Dankook University, Cheonan 330714 (Korea, Republic of); Ferreira, José M.F., E-mail: jmf@ua.pt [Department of Materials and Ceramics Engineering, University of Aveiro, CICECO, 3810-193 Aveiro (Portugal)

    2015-08-01

    The present study reports on the influence of partial replacement of MgO by ZnO on the structure, crystallisation behaviour and bioactivity of alkali-free bioactive glass-ceramics (GCs). A series of glass compositions (mol%): 36.07 CaO–(19.24 − x) MgO–x ZnO–5.61 P{sub 2}O{sub 5}–38.49 SiO{sub 2}–0.59 CaF{sub 2} (x = 2–10) have been synthesised by melt–quench technique. The structural changes were investigated by solid-state magic angle spinning nuclear magnetic resonance (MAS-NMR), X-ray diffraction and differential thermal analysis. The sintering and crystallisation behaviours of glass powders were studied by hot-stage microscopy and differential thermal analysis, respectively. All the glass compositions exhibited good densification ability resulting in well sintered and mechanically strong GCs. The crystallisation and mechanical behaviour were studied under non-isothermal heating conditions at 850 °C for 1 h. Diopside was the primary crystalline phase in all the GCs followed by fluorapatite and rankinite as secondary phases. Another phase named petedunnite was identified in GCs with ZnO content > 4 mol. The proliferation of mesenchymal stem cells (MSCs) and their alkaline phosphatase activity (ALP) on GCs was revealed to be Zn-dose dependent with the highest performance being observed for 4 mol% ZnO. - Highlights: • The addition of zinc to glasses decreased T{sub g} and promoted crystallisation. • Zinc enhanced the sintering ability and increased mechanical strength by 36%. • The apatite formation ability decreased with increasing Zn contents. • Zinc stimulated mesenchymal stem cell proliferation in a dose dependent manner.

  14. Influence of ZnO/MgO substitution on sintering, crystallisation, and bio-activity of alkali-free glass-ceramics

    International Nuclear Information System (INIS)

    Kapoor, Saurabh; Goel, Ashutosh; Correia, Ana Filipa; Pascual, Maria J.; Lee, Hye-Young; Kim, Hae-Won; Ferreira, José M.F.

    2015-01-01

    The present study reports on the influence of partial replacement of MgO by ZnO on the structure, crystallisation behaviour and bioactivity of alkali-free bioactive glass-ceramics (GCs). A series of glass compositions (mol%): 36.07 CaO–(19.24 − x) MgO–x ZnO–5.61 P 2 O 5 –38.49 SiO 2 –0.59 CaF 2 (x = 2–10) have been synthesised by melt–quench technique. The structural changes were investigated by solid-state magic angle spinning nuclear magnetic resonance (MAS-NMR), X-ray diffraction and differential thermal analysis. The sintering and crystallisation behaviours of glass powders were studied by hot-stage microscopy and differential thermal analysis, respectively. All the glass compositions exhibited good densification ability resulting in well sintered and mechanically strong GCs. The crystallisation and mechanical behaviour were studied under non-isothermal heating conditions at 850 °C for 1 h. Diopside was the primary crystalline phase in all the GCs followed by fluorapatite and rankinite as secondary phases. Another phase named petedunnite was identified in GCs with ZnO content > 4 mol. The proliferation of mesenchymal stem cells (MSCs) and their alkaline phosphatase activity (ALP) on GCs was revealed to be Zn-dose dependent with the highest performance being observed for 4 mol% ZnO. - Highlights: • The addition of zinc to glasses decreased T g and promoted crystallisation. • Zinc enhanced the sintering ability and increased mechanical strength by 36%. • The apatite formation ability decreased with increasing Zn contents. • Zinc stimulated mesenchymal stem cell proliferation in a dose dependent manner

  15. Crystallisation and microstructure of low-silicon silumins with alloy additions

    Directory of Open Access Journals (Sweden)

    S. Pietrowski

    2011-07-01

    Full Text Available The paper presents the results of the analysis of crystallisation and microstructure of non-alloy silumins that contain: 2,0÷6,0% of Si and alloy additions, approximately: 4,0% Ni, 4,0% of Cu and 0,5% of Mg, the knowledge of which is still very little. It has been proven that in non-alloy silumins, the increase of silicone concentration causes extending of crystallisation time of the eutectic mixture α+and refinement of α phase dendrites. It also causes the increase of the temperature of crystallisation of the eutectic mixture α+ . Alloy additions: Ni, Cu and Mg decrease by approximately 30 C the liquidus and solidus temperatures of silumins and extend the time of their crystallisation by around 100 sec. in comparison with non-alloy silumins. It is caused by crystallisation of additional phases Al3NiCu, Mg2Si and Al2Cu. Nickel, copper and magnesium refine the microstructure of castings.

  16. Thermodynamic modelling of a membrane distillation crystallisation process for the treatment of mining wastewater.

    Science.gov (United States)

    Nathoo, Jeeten; Randall, Dyllon Garth

    2016-01-01

    Membrane distillation (MD) could be applicable in zero liquid discharge applications. This is due to the fact that MD is applicable at high salinity ranges which are generally outside the scope of reverse osmosis (RO) applications, although this requires proper management of precipitating salts to avoid membrane fouling. One way of managing these salts is with MD crystallisation (MDC). This paper focuses on the applicability of MDC for the treatment of mining wastewater by thermodynamically modelling the aqueous chemistry of the process at different temperatures. The paper is based on the typical brine generated from an RO process in the South African coal mining industry and investigates the effect water recovery and operating temperature have on the salts that are predicted to crystallise out, the sequence in which they will crystallise out and purities as a function of the water recovery. The study confirmed the efficacy of using thermodynamic modelling as a tool for investigating and predicting the crystallisation aspects of the MDC process. The key finding from this work was that, for an MDC process, a purer product can be obtained at higher operating temperatures and recoveries because of the inverse solubility of calcium sulphate.

  17. Timing of Crystallisation of the Lunar Magma Ocean Constrained by the Oldest Zircon

    Science.gov (United States)

    Nemchin, A.; Timms, N.; Pidgeon, R.; Geisler, T.; Reddy, S.; Meyer, C.

    2009-01-01

    The presently favoured concept for the early evolution of the Moon involves consolidation of debris from a giant impact of a Mars sized body with Earth forming a primitive Moon with a thick global layer of melt referred to as the Lunar Magma Ocean1 . It is widely accepted that many significant features observed on the Moon today are the result of crystallisation of this magma ocean. However, controversy exists over the precise timing and duration of the crystallisation process. Resolution of this problem depends on the establishment of precise and robust key crystallisation time points. We report a 4417 6 Myr old zircon in lunar breccia sample 72215,195, which provides a precisely determined younger limit for the solidification of the Lunar Magma Ocean. A model based on these data, together with the age of the Moon forming giant impact, defines an exponential time frame for crystallisation and suggests formation of anorthositic crust after about 80-85% of the magma ocean was solidified. In combination with other zircon ages the 4417 +/- 6 Myr age also suggests that the very small (less than a few per cent) residual portion of the magma ocean continued to solidify during the following 300-500 m.y.

  18. The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

    Directory of Open Access Journals (Sweden)

    Thai T. H. Nguyen

    2017-09-01

    Full Text Available Sono-crystallisation has been used to enhance crystalline product quality particularly in terms of purity, particle size and size distribution. In this work, the effect of impurities and ultrasound on crystallisation processes (nucleation temperature, yield and crystal properties (crystal size distribution determined by Focused Beam Reflectance Measurement (FBRM, crystal habit, filtration rate and impurity content in the crystal product by Liquid Chromatography-Mass Spectroscopy (LC-MS were investigated in bulk suspension crystallisation experiments with and without the use of ultrasound. The results demonstrate that ultrasonic intervention has a significant effect on both crystallisation and product crystal properties. It increases the nucleation rate resulting in smaller particles and a narrower Particle Size Distribution (PSD, the yield has been shown to be increase as has the product purity. The effect of ultrasound is to reduce the level acetanilide impurity incorporated during growth from a 2 mol% solution of the selected impurity from 0.85 mol% to 0.35 mol% and likewise ultrasound reduces the uptake of metacetamol from 1.88 mol% to 1.52 mol%.

  19. Elucidating the mechanisms of nanodiamond-promoted structural disruption of crystallised lipid.

    Science.gov (United States)

    Hughes, Zak E; Walsh, Tiffany R

    2016-10-12

    The removal or structural disruption of crystallised lipid is a pivotal but energy-intensive step in a wide range of industrial and biological processes. Strategies to disrupt the structure of crystallised lipid in aqueous solution at lower temperatures are much needed, where nanoparticle-based strategies show enormous promise. Using the aqueous tristearin bilayer as a model for crystallised lipid, we demonstrate that the synergistic use of surfactant and detonation nanodiamonds can depress the onset temperature at which disruption of the crystallised lipid structure occurs. Our simulations reveal the molecular-scale mechanisms by which this disruption takes place, indicating that the nanodiamonds serve a dual purpose. First, the nanodiamonds are predicted to facilitate delivery of surfactant to the lipid/water interface, and second, nanodiamond adsorption acts to roughen the lipid/water interface, enhancing ingress of surfactant into the bilayer. We find the balance of the hydrophobic surface area of the nanodiamond and the nanodiamond surface charge density to be a key determinant of the effectiveness of using nanodiamonds to facilitate lipid disruption. For the nanodiamond size considered here, we identify a moderate surface charge density, that ensures the nanodiamonds are neither too hydrophobic nor too hydrophilic, to be optimal.

  20. On the competition in phase formation during the crystallisation of Al-Ni-Y metallic glasses

    International Nuclear Information System (INIS)

    Styles, M.J.; Sun, W.W.; East, D.R.; Kimpton, J.A.; Gibson, M.A.; Hutchinson, C.R.

    2016-01-01

    Glassy metals exhibit a range of interesting properties including high strength and corrosion resistance, but often have poor toughness and tensile ductility in the fully amorphous state. It has been shown that combinations of desirable properties can be achieved by the partial crystallisation of glass-forming alloys, either during controlled solidification or by annealing a fully amorphous glass. The aim of this investigation is to understand the competition in phase formation during the crystallisation of metallic glasses in the Al-Ni-Y system. High-resolution, in situ synchrotron powder diffraction has been used to quantitatively follow the evolution of phases in 5 different alloys between Al 87 Ni 9 Y 4 and Al 75 Ni 15 Y 10 , as they were continuously heated to melting and subsequently cooled back to ambient temperature. Upon heating, the first crystallisation product was found to vary from FCC Al to the intermetallic Al 9 Ni 2 phase with increasing Ni concentration. In addition, the crystallisation sequence also changed from a two-stage to a three-stage process. High number densities of crystallites (∼10 23  m −3 ) were observed initially for both FCC Al and Al 9 Ni 2 . Upon cooling, the partially disordered Al 9 Ni 3 Y phase was found to form preferentially over the intermetallic phases observed during heating. The difference in competition in phase formation during heating and cooling are discussed in terms of nucleation barriers calculated using a recent thermodynamic assessment of the Al-Ni-Y system. The role of compositional heterogeneities in the as-quenched glasses and long-range diffusion on the nucleation process is discussed. - Graphical abstract: High-resolution, in situ synchrotron powder diffraction has been used to quantitatively follow the evolution of phases in 5 different alloys between Al 87 Ni 9 Y 4 and Al 75 Ni 15 Y 10 , as they were continuously heated to melting and subsequently cooled back to ambient temperature. Upon heating, the

  1. On-line and in-situ x-ray diffraction analysis of the crystallisation of important pharmaceutical materials

    International Nuclear Information System (INIS)

    Hastings, S.

    1999-01-01

    Full text: The crystallisation process is an important unit operation for the separation and purification of many chemical products, particularly in the pharmaceutical industry. Variations in the conditions of crystallisation can lead to the formation of different polymorphic forms which are often meta-stable phases which results in phase conversion at different rates to the stable form. Our group, in collaboration with many industrial sponsors, have developed a number of online techniques which help to optimise the processing conditions of many of these specialty materials. In particular, on-line and in-situ X-ray diffraction (XRD) has been used to monitor the crystallisation of pharmaceutical materials. Several novel in-situ X-ray cells have been developed, in particular; a solution cell, which allows us to control and hence optimise crystallographic conditions such as temperature and pH whilst monitoring the crystal structure of the sample as it crystallises from solution. In conjunction with XRD data information on turbidity (% light transmittance) is taken to analyse solvent-mediated crystallisation. This technique gives information on the temperatures at which the system crystallises and dissolves. From this the meta-stable zone width (MSZW) can be calculated and then directly related to the crystal structure of the particles formed. The current system being studied is the crystallisation of stearic acid, a common pharmaceutical excipient, in various polar and non-polar solvents in order to ascertain the effect that the polarity of the solvent has on the polymorphic form crystallised. By combining such kinetic assessment with measurements of resulting particle structure the potential to optimise the process to produce optimal particle properties is obtainable. Copyright (1999) Australian X-ray Analytical Association Inc

  2. Optical system for the Protein Crystallisation Diagnostics Facility (PCDF) on board the ISS

    Science.gov (United States)

    Joannes, Luc; Dupont, Olivier; Dewandel, Jean-Luc; Ligot, Renaud; Algrain, Hervé

    2004-06-01

    The Protein Crystallisation Diagnostic Facility (PCDF) is a multi-user facility to study the protein crystallisation under the conditions of micro-gravity onboard the International Space Station (ISS) Columbus facility. Large size protein crystals will growth under reduced gravity in thermally controlled reactors. A combination of diagnostic tools like video system, microscope, interferometer, and light scattering device shall help to understand the growth phenomena. Common methods of protein crystallisation shall be performed in PCDF: Dialysis where the protein solution and the salt solution are separated by a semi-permeable membrane. Extended Length Dialysis Batch where the saturation to get crystals is achieved by changing the concentration of the protein in the sample liquid. The overall ESA project is leaded by EADS Space Transportation, Friedrichshafen, Germany. Lambda-X is responsible for the Optical System (OS), with Verhaert Design and Development as sub-contractor for the mechanical design. The OS includes different compact parts: Original illumination systems based on LEDs of difference colours; Quantitative Mach-Zehnder interferometers to measure the concentration distribution around crystals; Imaging assemblies to visualize the protein volume with different field of views. The paper concentrates on the description of each part, and in particular on the imaging assembly which allow switching from one field of view to another by passive elements only.

  3. Crystallisation of a Lennard-Jones fluid by large scale molecular dynamics simulation

    International Nuclear Information System (INIS)

    Snook, I.

    1998-01-01

    Full text: The evolution of the structure of a large system of atoms interacting via a Lennard-Jones pair potential was simulated by the use of the Molecular Dynamics computer simulation technique. The system was initially equilibrated in the one phase region of the phase diagram at a temperature above critical then a temperature quench was performed which placed the system in a region were the single fluid phase was unstable. Quenches to below the triple point temperature gave rise to crystallisation The mechanism and final morphology is shown to depend strongly on the starting conditions e.g. the starting density

  4. Coarse-grained modelling of triglyceride crystallisation: a molecular insight into tripalmitin tristearin binary mixtures by molecular dynamics simulations

    Science.gov (United States)

    Pizzirusso, Antonio; Brasiello, Antonio; De Nicola, Antonio; Marangoni, Alejandro G.; Milano, Giuseppe

    2015-12-01

    The first simulation study of the crystallisation of a binary mixture of triglycerides using molecular dynamics simulations is reported. Coarse-grained models of tristearin (SSS) and tripalmitin (PPP) molecules have been considered. The models have been preliminarily tested in the crystallisation of pure SSS and PPP systems. Two different quenching procedures have been tested and their performances have been analysed. The structures obtained from the crystallisation procedures show a high orientation order and a high content of molecules in the tuning fork conformation, comparable with the crystalline α phase. The behaviour of melting temperatures for the α phase of the mixture SSS/PPP obtained from the simulations is in qualitative agreement with the behaviour that was experimentally determined.

  5. Coarse-grained modelling of triglyceride crystallisation: a molecular insight into tripalmitin tristearin binary mixtures by molecular dynamics simulations

    International Nuclear Information System (INIS)

    Pizzirusso, Antonio; De Nicola, Antonio; Milano, Giuseppe; Brasiello, Antonio; Marangoni, Alejandro G

    2015-01-01

    The first simulation study of the crystallisation of a binary mixture of triglycerides using molecular dynamics simulations is reported. Coarse-grained models of tristearin (SSS) and tripalmitin (PPP) molecules have been considered. The models have been preliminarily tested in the crystallisation of pure SSS and PPP systems. Two different quenching procedures have been tested and their performances have been analysed. The structures obtained from the crystallisation procedures show a high orientation order and a high content of molecules in the tuning fork conformation, comparable with the crystalline α phase. The behaviour of melting temperatures for the α phase of the mixture SSS/PPP obtained from the simulations is in qualitative agreement with the behaviour that was experimentally determined. (paper)

  6. Inhibition of ice crystallisation in highly viscous aqueous organic acid droplets

    Directory of Open Access Journals (Sweden)

    B. J. Murray

    2008-09-01

    Full Text Available Homogeneous nucleation of ice within aqueous solution droplets and their subsequent crystallisation is thought to play a significant role in upper tropospheric ice cloud formation. It is normally assumed that homogeneous nucleation will take place at a threshold supersaturation, irrespective of the identity of the solute, and that rapid growth of ice particles will follow immediately after nucleation. However, it is shown here through laboratory experiments that droplets may not readily freeze in the very cold tropical tropopause layer (TTL, typical temperatures of 186–200 K. In these experiments ice crystal growth in citric acid solution droplets did not occur when ice nucleated below 197±6 K. Citric acid, 2-hydroxypropane-1,2,3-tricarboxyllic acid, is a molecule with similar functionality to oxygenated organic compounds which are ubiquitous in atmospheric aerosol. It is therefore thought to be a sensible proxy for atmospheric organic material. Evidence is presented that suggests citric acid solution droplets become ultra-viscous and form glassy solids under atmospherically relevant conditions. Diffusion of liquid water molecules to ice nuclei is expected to be very slow in ultra-viscous solution droplets and nucleation is negligible in glassy droplets; this most likely provides an explanation for the experimentally observed inhibition of ice crystallisation. The implications of ultra-viscous and glassy solution droplets for ice cloud formation and supersaturations in the TTL are discussed.

  7. A zero density change phase change memory material: GeTe-O structural characteristics upon crystallisation.

    Science.gov (United States)

    Zhou, Xilin; Dong, Weiling; Zhang, Hao; Simpson, Robert E

    2015-06-11

    Oxygen-doped germanium telluride phase change materials are proposed for high temperature applications. Up to 8 at.% oxygen is readily incorporated into GeTe, causing an increased crystallisation temperature and activation energy. The rhombohedral structure of the GeTe crystal is preserved in the oxygen doped films. For higher oxygen concentrations the material is found to phase separate into GeO2 and TeO2, which inhibits the technologically useful abrupt change in properties. Increasing the oxygen content in GeTe-O reduces the difference in film thickness and mass density between the amorphous and crystalline states. For oxygen concentrations between 5 and 6 at.%, the amorphous material and the crystalline material have the same density. Above 6 at.% O doping, crystallisation exhibits an anomalous density change, where the volume of the crystalline state is larger than that of the amorphous. The high thermal stability and zero-density change characteristic of Oxygen-incorporated GeTe, is recommended for efficient and low stress phase change memory devices that may operate at elevated temperatures.

  8. Influence of crystallised igneous intrusions on fault nucleation and reactivation during continental extension

    Science.gov (United States)

    Magee, Craig; McDermott, Kenneth G.; Stevenson, Carl T. E.; Jackson, Christopher A.-L.

    2014-05-01

    Continental rifting is commonly accommodated by the nucleation of normal faults, slip on pre-existing fault surfaces and/or magmatic intrusion. Because crystallised igneous intrusions are pervasive in many rift basins and are commonly more competent (i.e. higher shear strengths and Young's moduli) than the host rock, it is theoretically plausible that they locally intersect and modify the mechanical properties of pre-existing normal faults. We illustrate the influence that crystallised igneous intrusions may have on fault reactivation using a conceptual model and observations from field and subsurface datasets. Our results show that igneous rocks may initially resist failure, and promote the preferential reactivation of favourably-oriented, pre-existing faults that are not spatially-associated with solidified intrusions. Fault segments situated along strike from laterally restricted fault-intrusion intersections may similarly be reactivated. This spatial and temporal control on strain distribution may generate: (1) supra-intrusion folds in the hanging wall; (2) new dip-slip faults adjacent to the igneous body; or (3) sub-vertical, oblique-slip faults oriented parallel to the extension direction. Importantly, stress accumulation within igneous intrusions may eventually initiate failure and further localise strain. The results of our study have important implications for the structural of sedimentary basins and the subsurface migration of hydrocarbons and mineral-bearing fluids.

  9. Polydispersity effects in the crystallisation of hard-sphere colloidal samples

    International Nuclear Information System (INIS)

    Martin, S.; Bryant, G.

    2002-01-01

    Full text: Colloidal particles mimicking hard-sphere behaviour have been shown to undergo the freezing and melting transition as predicted from computer simulations. Due to the large size and slow movement of the colloidal particles, it is possible to measure the time dependence of the growth of the main Bragg reflection using laser light scattering. The new data presented here was taken on a newly built crystallisation spectrometer which averages the Bragg reflections over the whole Debye-Scherrer cone, where previous work has mostly been done with the detector fixed in one plane. This new apparatus allows us to observe the crystallisation process at earlier times, on lower density samples than had previously been possible. Measurements have been made on samples made from colloidal particles with radii 320nm and 247 nm and polydispersities of ∼6.9% and >8% respectively. The results have been compared with other results from particles with >4% polydispersity. The results show that increasing the polydispersity in the particles increases the time lag before significant crystal growth occurs, but polydispersity doesn't appear to directly affect the rate of crystal growth

  10. An Overview on Magnetic Field and Electric Field Interactions with Ice Crystallisation; Application in the Case of Frozen Food

    Directory of Open Access Journals (Sweden)

    Piyush Kumar Jha

    2017-10-01

    Full Text Available Ice nucleation is a stochastic process and it is very difficult to be controlled. Freezing technologies and more specifically crystallisation assisted by magnetic, electric and electromagnetic fields have the capability to interact with nucleation. Static magnetic field (SMF may affect matter crystallisation; however, this is still under debate in the literature. Static electric field (SEF has a significant effect on crystallisation; this has been evidenced experimentally and confirmed by the theory. Oscillating magnetic field induces an oscillating electric field and is also expected to interact with water crystallisation. Oscillating electromagnetic fields interact with water, perturb and even disrupt hydrogen bonds, which in turn are thought to increase the degree of supercooling and to generate numerous fine ice crystals. Based on the literature, it seems that the frequency has an influence on the above-mentioned phenomena. This review article summarizes the fundamentals of freezing under magnetic, electric and electromagnetic fields, as well as their applicability and potentials within the food industry.

  11. Effect of Pressure on the Crystallisation of AlSi7Mg Alloy

    Directory of Open Access Journals (Sweden)

    Pastirčák R.

    2017-12-01

    Full Text Available This paper deals with influencing the crystallisation of Al alloys by a direct squeeze casting method. The effects of changed cooling rates of the casting is evaluated using a heat transfer coefficient at different casting conditions. The experimental results obtained by temperature measurement of the casting and the mould were used to predict the casting and mould surface temperatures using regression curves. The measured temperatures in the sub-surface layers were used to determine the amount of heat transferred from the casting to the mould. The amount of transferred heat increased 20-fold due to the effect of pressure. We also evaluated the effect of the acting pressure on the mechanical properties and microstructure of the alloy used. The process parameters were varied in the experiment.

  12. Crystallisation and structural studies of monodisperse nylon oligomers and related polymers

    International Nuclear Information System (INIS)

    Sikorski, P.T.

    2001-11-01

    Using electron and X-ray diffraction data, together with computerised molecular modeling, the structures of monodisperse nylon oligomers and related polymers have been investigated. Structural changes on heating were also studied. The molecules were crystallised from solution and their morphologies examined using optical and transmission electron microscopy. Lath-like lamellar crystals of the polyester poly-β-propiolactone were crystallised isothermally. The interpretation of the diffraction data with the use of molecular modeling led to the discovery of the new crystalline structure, the γ-structure. In the γ-structure, the polyester chain is in an all-trans conformation and the structure consists of a two-chain, basal-faced, orthorhombic unit cell. The setting angles, with respect to the a axis, are ± 51.5 deg for the corner and centre chains, respectively. The lamellae are 5 nm in thickness and the chains run orthogonal to the lamellar surface. The general fold direction is along the a-axis (long axis of the crystal) and the chain folds successively in the [110] and [11-bar0] directions. Three different nylon 4 6 oligomers were crystallised from solution using a range of crystallisation methods. The 4- and 8-amide molecules were found to form three-dimensional crystals, in which the crystal thickness was much greater than the molecular length. The structure was found to be different from the nylon 4 6 polymer reported previously. It was found that the type of hydrogen-bonded sheet formed by these molecules can influence the way in which these sheets stack to form crystals. In addition, a study of the 9-amide molecule showed that a particular type of hydrogen-bonded sheet, a-sheet, is preferred for nylon 4 6. This discovery suggests that an amide unit is found in the fold in the chain-folded nylon 4 6 polymer crystals, to allow the a-sheets to be formed. It is not a consequence of a need to form a stress-free fold. In the regular adjacent re-entry chain

  13. Numerical Simulations of Melting-Crystallisation Processes at the Boundaries Between Magma Oceans and Solid Mantle

    Science.gov (United States)

    Bolrão, D. P.; Rozel, A.; Morison, A.; Labrosse, S.; Tackley, P. J.

    2017-12-01

    The idea that the Earth had a global magma ocean, mostly created by impacts, core formation, radiogenic and tidal heating, is well accepted nowadays. When this ocean starts to crystallise, if the melt is denser than the solid, a basal magma ocean is created below the solid part. These two magma oceans influence the dynamics and evolution of solid mantle. Near the boundaries, the vertical flow in the solid part creates a topography. If this topography is destroyed by melting/crystallisation processes in a time scale much shorter than the time needed to adjust the topography by viscous relaxation, then matter can cross the boundary. In this case, the boundary is said to be permeable. On the other hand, if this time is longer, matter cannot cross and the boundary is said impermeable. This permeability is defined by a non-dimensional phase change number, φ, introduced by Deguen, 2013. This φ is the ratio of the two timescales mentioned, and defines a permeable boundary when φ « 1, and an impermeable one when φ » 1. To understand the impact of magma oceans on the dynamics of the solid mantle, we use the convection code StagYY, with a 2D spherical annulus geometry, to compute the convection of the solid part. Our results show different convection behaviours depending on the type of boundary chosen. For the permeable case, we investigate the thermo-compositional evolution of the solid domain, explicitly taking into account the compositional evolution of the magma oceans. Reference: Deguen, R. Thermal convection in a spherical shell with melting/freezing at either or both of its boundaries. Journal of Earth Science, Vol. 24, No. 5, p. 669-682, 2013. doi: 10.1007/s12583-013-0364-8

  14. ATLAS Outreach Highlights

    CERN Document Server

    Cheatham, Susan; The ATLAS collaboration

    2016-01-01

    The ATLAS outreach team is very active, promoting particle physics to a broad range of audiences including physicists, general public, policy makers, students and teachers, and media. A selection of current outreach activities and new projects will be presented. Recent highlights include the new ATLAS public website and ATLAS Open Data, the very recent public release of 1 fb-1 of ATLAS data.

  15. Studies Highlight Biodiesel's Benefits

    Science.gov (United States)

    , Colo., July 6, 1998 — Two new studies highlight the benefits of biodiesel in reducing overall air Energy's National Renewable Energy Laboratory (NREL) conducted both studies: An Overview of Biodiesel and Petroleum Diesel Life Cycles and Biodiesel Research Progress, 1992-1997. Biodiesel is a renewable diesel

  16. Clinical highlights from Amsterdam

    Directory of Open Access Journals (Sweden)

    Jouke T. Annema

    2016-07-01

    Full Text Available This article contains highlights and a selection of the scientific advances from the Clinical Assembly that were presented at the 2015 European Respiratory Society International Congress in Amsterdam, the Netherlands. The most relevant topics for clinicians will be discussed, covering a wide range of areas including interventional pulmonology, rehabilitation and chronic care, thoracic imaging, diffuse and parenchymal lung diseases, and general practice and primary care. In this comprehensive review, exciting novel data will be discussed and put into perspective.

  17. FY 2016 Research Highlights

    Energy Technology Data Exchange (ETDEWEB)

    2017-03-23

    This fact sheet summarizes the research highlights for the Clean Energy Manufacturing Analysis Center (CEMAC) for Fiscal Year 2106. Topics covered include additive manufacturing for the wind industry, biomass-based chemicals substitutions, carbon fiber manufacturing facility siting, geothermal power plant turbines, hydrogen refueling stations, hydropower turbines, LEDs and lighting, light-duty automotive lithium-ion cells, magnetocaloric refrigeration, silicon carbide power electronics for variable frequency motor drives, solar photovoltaics, and wide bandgap semiconductor opportunities in power electronics.

  18. IGC highlights 1988

    International Nuclear Information System (INIS)

    1989-01-01

    The major thrust of the research and development (R and D) activities of the Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam is oriented towards mastering fast breeder reactor (FBR) technology. Towards this end, its current R and D activities are carried out in a wide variety of disciplines. Highlights of its R and D activities during 1988 are summarised under the headings: Reactor Engineering and Design, Reactor Physics and Safety, Materials Science and Technology, Sodium Chemistry and Technology, Fuel Reprocessing and Electronics and Instrumentation. The text is illustrated with a number of figures, graphs and coloured pictures. (M.G.B.). figs., tabs

  19. BARC highlights '88

    International Nuclear Information System (INIS)

    1989-01-01

    Highlights of research and development activities of the Bhabha Atomic Research Centre (BARC), Bombay during 1988 are presented in chapters entitled: Physical Sciences, Chemical Sciences, Materials and Materials Sciences, Radioisotopes, Reactors, Fuel Cycle, Radiological Safety and Protection, Electronics and Instrumentation, Engineering Services, and Life Sciences. Main thrust of the R and D activities of BARC is on nuclear power reactor technology and all stages of nuclear fuel cycle. Some activities are also in the frontier areas such as high temperature superconductivity and inertial confinement fusion. (M.G.B.). figs., tabs., coloured ills

  20. Expression of the marA, soxS, acrB and ramA genes related to the AcrAB/TolC efflux pump in Salmonella entérica strains with and without quinolone resistance-determining regions gyrA gene mutations

    Directory of Open Access Journals (Sweden)

    Rafaela Gomes Ferrari

    2013-04-01

    Full Text Available Several studies have been conducted in recent years to elucidate the structure, function and significance of AcrB, MarA, SoxS and RamA in Salmonella enterica. In this study, the relative quantification of acrB, soxS, marA and ramA genes expression was evaluated in 14 strains of S. enterica, with or without accompanying mutations in the quinolone resistance-determining regions of the gyrA gene, that were exposed to ciprofloxacin during the exponential growth phase. The presence of ciprofloxacin during the log phase of bacterial growth activated the genes marA, soxS, ramA and acrB in all S. enterica strains analyzed in this study. The highest expression levels for acrB were observed in strains with gyrA mutation, and marA showed the highest expression in the strains without mutation. Considering only the strains with ciprofloxacin minimum inhibitory concentration values 0.125 [1]g/mL (low susceptibility, with and without mutations in gyrA, the most expressed gene was marA. In this study, we observed that strains resistant to nalidixic acid may express genes associated with the efflux pump and the expression of the AcrAB-TolC pump genes seems to occur independently of mutations in gyrA.

  1. Expression of the marA, soxS, acrB and ramA genes related to the AcrAB/TolC efflux pump in Salmonella entérica strains with and without quinolone resistance-determining regions gyrA gene mutations

    Directory of Open Access Journals (Sweden)

    Rafaela Gomes Ferrari

    Full Text Available Several studies have been conducted in recent years to elucidate the structure, function and significance of AcrB, MarA, SoxS and RamA in Salmonella enterica. In this study, the relative quantification of acrB, soxS, marA and ramA genes expression was evaluated in 14 strains of S. enterica, with or without accompanying mutations in the quinolone resistance-determining regions of the gyrA gene, that were exposed to ciprofloxacin during the exponential growth phase. The presence of ciprofloxacin during the log phase of bacterial growth activated the genes marA, soxS, ramA and acrB in all S. enterica strains analyzed in this study. The highest expression levels for acrB were observed in strains with gyrA mutation, and marA showed the highest expression in the strains without mutation. Considering only the strains with ciprofloxacin minimum inhibitory concentration values 0.125 [1]g/mL (low susceptibility, with and without mutations in gyrA, the most expressed gene was marA. In this study, we observed that strains resistant to nalidixic acid may express genes associated with the efflux pump and the expression of the AcrAB-TolC pump genes seems to occur independently of mutations in gyrA.

  2. Highlights from CMS

    CERN Document Server

    Autermann, Christian

    2018-01-01

    This article summarizes the latest highlights from the CMS experiment as presented at the Lepton Photon conference 2017 in Guangzhou, China. A selection of the latest physics results, the latest detector upgrades, and the current detector status are discussed. CMS has analyzed the full dataset of proton-proton collision data delivered by the LHC in 2016 at a center-of-mass energy of $13$\\,TeV corresponding to an integrated luminosity of $40$\\,fb$^{-1}$. The leap in center-of-mass energy and in luminosity with respect to the $7$ and $8$\\,TeV runs enabled interesting and relevant new physics results. A new silicon pixel tracking detector was installed during the LHC shutdown 2016/17 and has successfully started operation.

  3. PSI scientific highlights 2012

    International Nuclear Information System (INIS)

    Piwnicki, P.; Dury, T.

    2013-05-01

    This comprehensive report issued by the Paul Scherrer Institute (PSI) reviews research in various areas carried out by the institute in 2012. Also, the various facilities to be found at the institute are described. Research focus and highlights are discussed. These include work done using synchrotron light, neutrons and muons as well as work done in the particle physics, microtechnology and nanotechnology areas. Further areas of research include biomolecular research, radiopharmacy, radiochemistry and environmental chemistry. Other areas covered include general energy research and work done at the Competence Center for Energy and Mobility CCEM, work done on nuclear energy safety as well as systems analysis in the environmental and energy areas. The report is concluded with facts and figures on the PSI, its Advisory Board and its organisational structures

  4. PSI scientific highlights 2011

    International Nuclear Information System (INIS)

    Piwnicki, P.

    2012-04-01

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) presents the major highlights of the work done at the Paul Scherrer Institute, Switzerland, in 2011. According to the institute's director, work was concerned with the design and analysis of advanced materials with new functionalities, for application in fields as diverse as communications and energy technology, transportation, construction and medicine. Of particular topical interest are research projects on materials for application in the field of energy, for example for improving batteries for future electrically powered vehicles. Another example is in the field of catalysts. Environmentally harmful compounds, such as nitrogen oxide and sulphur dioxide produced in an engine, are transformed into nontoxic gases through catalytic conversion. Work progress on the SwissFEL installation is noted, including a breakthrough for SwissFEL main Linac C-band accelerating systems. Further topics in relation to the SwissFEL system are noted. Planning of the initial set of experimental stations at the SwissFEL is discussed and close collaboration with growing number of user communities is noted. Cross-Correlation Scattering, and a theoretical framework for this method is being developed and experimentally verified, using artificial nanostructures and synchrotron radiation. Highlights of further research work are discussed, including topics such as Synchrotron light, work done on neutrons and muons, particle physics, micro and nanotechnology as well as on biomolecular research and radiopharmacy. Large research facilities are discussed as is the PSI proton therapy installation. General energy topics are looked at, as are nuclear energy and safety aspects and environmental and energy systems analysis. Various further work includes factors causing glacier retreat and aerosols. User facilities are listed, including accelerators, the SLS light source, the SINQ neutron source, the UCN ultra-cold neutron source

  5. Estimation of the growth kinetics for the cooling crystallisation of paracetamol and ethanol solutions

    Science.gov (United States)

    Mitchell, Niall A.; Ó'Ciardhá, Clifford T.; Frawley, Patrick J.

    2011-08-01

    This work details the estimation of the growth kinetics of paracetamol in ethanol solutions for cooling crystallisation processes, by means of isothermal seeded batch experiments. The growth kinetics of paracetamol crystals were evaluated in isolation, with the growth rate assumed to be size independent. Prior knowledge of the Metastable Zone Width (MSZW) was required, so that supersaturation ratios of 1.7-1.1 could be induced in solution without the occurrence of nucleation. The technique involved the utilisation of two in-situ Process Analytical Techniques (PATs), with a Focused Beam Reflectance Measurement (FBRM ®) utilised to ensure that negligible nucleation occurred and an Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) probe employed for online monitoring of solute concentration. Initial Particle Size Distributions (PSDs) were used in conjunction with desupersaturation profiles to determine the growth rate as a function of temperature and supersaturation. Furthermore, the effects of seed loading and size on the crystal growth rate were investigated. A numerical model, incorporating the population balance equation and the method of moments, was utilised to describe the crystal growth process. Experimental parameters were compared to the model simulation, with the accuracy of the model validated by means of the final product PSDs and solute concentration.

  6. The Metastable City and the Politics of Crystallisation: Protesting and Policing in Kampala

    Directory of Open Access Journals (Sweden)

    Joschka Philipps

    2016-01-01

    Full Text Available When protests break out in downtown Kampala they tend to transform a fluid urban environment into bounded political camps, and myriad ambiguous concerns into comparatively clear-cut political issues. This article traces this process and conceptualises Kampala’s urban politics as a politics of crystallisation: as attempts to structure highly fluid dynamics into something concrete. The article is based on ethnographic research amongst opposition activists and the police forces. Both seek to activate political boundaries and make people gravitate towards their respective side. But in line with the fluidity of urban everyday life, they also work and collaborate across these boundaries. The national regime and the opposition thus function not as permanent, stable structures, but as processes, as fields of gravity whose emergence is incited and inhibited, financed, and policed. Drawing on Gilbert Simondon’s theory of individuation and AbdouMaliq Simone’s work on urbanity, this analytical framework offers a dynamic reading of urban contentious politics in general, and a reinterpretation of the paradoxes of power in African politics in particular.

  7. RESEARCH HIGHLIGHTS IN IAS

    Directory of Open Access Journals (Sweden)

    Marko Kreft

    2017-03-01

    Full Text Available We are reviewing and commenting highlights of the research published in Image Analysis and Stereology journal (IAS, volume 35, where 16 original research papers on image analysis, computer vision, modelling, and other approaches were published. We have reported on the precision of curve length estimation in the plane. Further, a focus was on a robust estimation technique for 3D point cloud registration. Next contribution in computer vision was on the accuracy of stereo matching algorithm based on illumination control. An attempt was also made to automatically diagnose prenatal cleft lip with representative key points and identify the type of defect in three-dimensional ultrasonography. Similarly, a new report is presenting estimation of torsion of digital curves in 3D images and next, the nuchal translucency by ultrasound is being analyzed. Also in ophthalmology, image analysis may help physicians to establish a correct diagnosis, which is supported by a new approach to measure tortuosity of retinal vessel. Another report of medical significance analyzed correlation of the shape parameters for characterization of images of corneal endothelium cells. Shape analysis is also an important topic in material science, e.g. in analyzing fine aggregates in concrete. As in concrete, in fiber reinforced composites image analysis may aid in improved quality, where the direction of fibers have decisive impact on properties. Automatic defect detection using a computer vision system improves productivity quality in industrial production, hence we report of a new Haar wavelet-based approach.

  8. Splice variants of perlucin from Haliotis laevigata modulate the crystallisation of CaCO3.

    Directory of Open Access Journals (Sweden)

    Tanja Dodenhof

    Full Text Available Perlucin is one of the proteins of the organic matrix of nacre (mother of pearl playing an important role in biomineralisation. This nacreous layer can be predominately found in the mollusc lineages and is most intensively studied as a compound of the shell of the marine Australian abalone Haliotis laevigata. A more detailed analysis of Perlucin will elucidate some of the still unknown processes in the complex interplay of the organic/inorganic compounds involved in the formation of nacre as a very interesting composite material not only from a life science-based point of view. Within this study we discovered three unknown Perlucin splice variants of the Australian abalone H. laevigata. The amplified cDNAs vary from 562 to 815 base pairs and the resulting translation products differ predominantly in the absence or presence of a varying number of a 10 mer peptide C-terminal repeat. The splice variants could further be confirmed by matrix-assisted laser desorption ionisation time of flight mass spectrometry (MALDI-ToF MS analysis as endogenous Perlucin, purified from decalcified abalone shell. Interestingly, we observed that the different variants expressed as maltose-binding protein (MBP fusion proteins in E. coli showed strong differences in their influence on precipitating CaCO3 and that these differences might be due to a splice variant-specific formation of large protein aggregates influenced by the number of the 10 mer peptide repeats. Our results are evidence for a more complex situation with respect to Perlucin functional regulation by demonstrating that Perlucin splice variants modulate the crystallisation of calcium carbonate. The identification of differentially behaving Perlucin variants may open a completely new perspective for the field of nacre biomineralisation.

  9. Crystal growth in EPDM by chemi-crystallisation as a function of the neutron irradiation dose and flux level

    International Nuclear Information System (INIS)

    Lambri, O.A.; Salvatierra, L.M.; Sanchez, F.A.; Matteo, C.L.; Sorichetti, P.A.; Celauro, C.A.

    2005-01-01

    Neutron irradiation at room temperature were performed on EPDM (ethylene-propylene-diene monomer) in two different nuclear reactors at different fluxes. The effect of the irradiation on the chain arrangement in the polymer, as a function of the dose is discussed. Different crystal concentrations and crystal shapes, developed by chemi-crystallisation, are obtained depending on the neutron dose. In addition the radiation damage degree in the polymer depends both on the dose and the flux level. Dynamical mechanical analysis, swelling studies, X-ray diffraction, differential thermal analysis and infrared studies were employed as experimental techniques

  10. The potential for the fabrication of wires embedded in the crystalline silicon substrate using the solid phase segregation of gold in crystallising amorphous volumes

    International Nuclear Information System (INIS)

    Liu, A.C.Y.; McCallum, J.C.

    2004-01-01

    The refinement of gold in crystallising amorphous silicon volumes was tested as a means of creating a conducting element embedded in the crystalline matrix. Amorphous silicon volumes were created by self-ion-implantation through a mask. Five hundred kiloelectronvolt Au + was then implanted into the volumes. The amorphous volumes were crystallised on a hot stage in air, and the crystallisation was characterised using cross sectional transmission electron microscopy. It was found that the amorphous silicon volumes crystallised via solid phase epitaxy at all the lateral and vertical interfaces. The interplay of the effects of the gold and also the hydrogen that infilitrated from the surface oxide resulted in a plug of amorphous material at the surface. Further annealing at this temperature demonstrated that the gold, once it had reached a certain critical concentration nucleated poly-crystalline growth instead of solid phase epitaxy. Time resolved reflectivity and Rutherford backscattering and channeling measurements were performed on large area samples that had been subject to the same implantation regime to investigate this system further. It was discovered that the crystallisation dynamics and zone refinement of the gold were complicated functions of both gold concentration and temperature. These findings do not encourage the use of this method to obtain conducting elements embedded in the crystalline silicon substrate

  11. Investigation of the hydrothermal crystallisation of the perovskite solid solution NaCe{sub 1−x}La{sub x}Ti{sub 2}O{sub 6} and its defect chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Harunsani, Mohammad H. [Department of Chemistry, University of Warwick, Coventry CV4 7AL (United Kingdom); Woodward, David I. [Department of Physics, University of Warwick, Coventry CV4 7Al (United Kingdom); Peel, Martin D.; Ashbrook, Sharon E. [School of Chemistry, and EaStCHEM University of St. Andrews, North Haugh, St. Andrews, KY16 9ST (United Kingdom); Walton, Richard I., E-mail: r.i.walton@warwick.ac.uk [Department of Chemistry, University of Warwick, Coventry CV4 7AL (United Kingdom)

    2013-11-15

    Perovskites of nominal composition NaCe{sub 1−x}La{sub x}Ti{sub 2}O{sub 6} (0≤x≤1) crystallise directly under hydrothermal conditions at 240 °C. Raman spectroscopy shows distortion from the ideal cubic structure and Rietveld analysis of powder X-ray and neutron diffraction reveals that the materials represent a continuous series in rhombohedral space group R3-bar c. Ce L{sub III}-edge X-ray absorption near edge structure spectroscopy shows that while the majority of cerium is present as Ce{sup 3+} there is evidence for Ce{sup 4+}. The paramagnetic Ce{sup 3+} affects the chemical shift and line width of {sup 23}Na MAS NMR spectra, which also show with no evidence for A-site ordering. {sup 2}H MAS NMR of samples prepared in D{sub 2}O shows the inclusion of deuterium, which IR spectroscopy shows is most likely to be as D{sub 2}O. The deuterium content is highest for the cerium-rich materials, consistent with oxidation of some cerium to Ce{sup 4+} to provide charge balance of A-site water. - Graphical abstract: A multi-element A-site perovskite crystallises directly from aqueous, basic solutions at 240 °C; while the paramagnetic effect of Ce{sup 3+} on the {sup 23}Na NMR shows a homogeneous solid-solution, the incorporation of A-site water is also found from {sup 2}H NMR and IR, with oxidation of some cerium to charge balance proved by XANES spectroscopy. Display Omitted - Highlights: • Direct hydrothermal synthesis allows crystallisation of a perovskite solid-solution. • XANES spectroscopy shows some oxidation of Ce{sup 3+} to Ce{sup 4+}. • The paramagnetism of Ce{sup 3+} shifts and broadens the {sup 23}Na solid-state NMR. • The perovskite materials incorporate water as an A-site defect.

  12. Estimation of the nucleation kinetics for the anti-solvent crystallisation of paracetamol in methanol/water solutions

    Science.gov (United States)

    Ó'Ciardhá, Clifford T.; Frawley, Patrick J.; Mitchell, Niall A.

    2011-08-01

    In this work the primary nucleation kinetics have been estimated for the anti-solvent crystallisation of paracetamol in methanol-water solutions from metastable zone widths (MSZW) and induction times at 25 °C. Laser back-scattering via a focused beam reflectance Measurement (FBRM ®) is utilised to detect the onset of nucleation. The theoretical approach of Kubota was employed to estimate the nucleation kinetics, which accounts for the sensitivity of the nucleation detection technique. This approach is expanded in this work to analyse the induction time for an anti-solvent crystallisation process. Solvent composition is known to have a significant impact on the measured induction times and MSZW. The induction time in this paper was measured from 40% to 70% mass water and the MSZW is measured from 40% to 60% mass water. The primary focus of the paper was to gauge the extent of how solvent composition affects nucleation kinetics so that this effect may be incorporated into a population balance model. Furthermore, the effects of solvent composition on the estimated nucleation rates are investigated. The primary nucleation rates were found to decrease with dynamic solvent composition, with the extent of their reduction linked to the gradient of the solubility curve. Finally, both MSZW and induction time methods have been found to produce similar estimates for the nucleation parameters.

  13. Influence of laser fluence in ArF-excimer laser assisted crystallisation of a-SiGe:H films

    International Nuclear Information System (INIS)

    Chiussi, S.; Lopez, E.; Serra, J.; Gonzalez, P.; Serra, C.; Leon, B.; Fabbri, F.; Fornarini, L.; Martelli, S.

    2003-01-01

    Polycrystalline silicon germanium (poly-SiGe) coatings are drawing increasing attention as active layers in solar cells, bolometers and various microelectronic devices. As a consequence, alternative low-cost production techniques, capable to produce such alloys with uniform and controlled grain size, become more and more attractive. Excimer laser assisted crystallisation, already assessed in thin film transistor production, has proved to be a valuable 'low-thermal budget' technique for the crystallisation of amorphous silicon. Main advantages are the high process quality and reproducibility as well as the possibility of tailoring the grain size in both, small selected regions and large areas. The feasibility of this technique for producing poly-SiGe films has been studied irradiating hydrogenated amorphous SiGe films with spatially uniform ArF-laser pulses of different fluences. Surface morphology, structure and chemical composition have been extensively characterised, demonstrating the need of using a 'step-by-step' process and a careful adjustment of both, total number of shots and laser fluence at each 'step' in order to diminish segregation effects and severe damages of the film surface and of segregation effects

  14. Influence of enzymatic and chemical interesterification on crystallisation properties of refined, bleached and deodourised (RBD) palm oil and RBD palm kernel oil blends.

    Science.gov (United States)

    Norizzah, Abd Rashid; Nur Azimah, Kamarulzaman; Zaliha, Omar

    2018-04-01

    Interesterification reaction involves rearrangement of the fatty acid radicals on the glycerol backbone, either randomly (chemical interesterification) or regioselectivity (enzymatic interesterification). Refined, bleached and deodourised palm oil (RBDPO) and palm kernel oil (RBDPKO) were blended in ratios from 25:75 to 75:25 (wt/wt). All blends were subjected to enzymatic (EI) and chemical interesterification (CI) using Lipozyme TL IM (4% w/w) and sodium methoxide (0.2% m/m) as the catalysts, respectively. The effect of EI and CI on the triacylglycerol (TAG) composition, thermal behaviour, polymorphism, crystal morphology and crystallisation kinetics were studied. The aim of this research is to characterise the nature of crystals in food product for certain desired structure. The crystallisation behaviour discussed in this study involves microstructure (PLM), polymorphism (XRD), thermal properties and crystallisation kinetics by DSC. The alteration in TAG composition was greater after CI as compared to EI with the reduction of LaLaLa (from 11.00% to 5.15%) and POO (from 14.28% to 4.87%). The DSC complete melting and crystallisation temperature of blend with 75% PO increased after CI, from 39.58 °C to 41.67 °C and from -30.84 °C to -28.33 °C, respectively. EI contributed to finer crystals than CI. However, the β' and β polymorph mixture and crystallisation kinetics (n = 2) of PO-PKO blends did not change after CI and EI. The knowledge on controlling crystallisation of RBDPO and RBDPKO blends is vital for proper processing condition like margarine production. Copyright © 2018 Elsevier Ltd. All rights reserved.

  15. Strain relaxation during solid-phase epitaxial crystallisation of Ge{sub x}Si{sub 1-x} alloy layers with depth dependent G{sub e} compositions

    Energy Technology Data Exchange (ETDEWEB)

    Wong, Wahchung; Elliman, R G; Kringhoj, P [Australian National Univ., Canberra, ACT (Australia). Research School of Physical Sciences

    1994-12-31

    The solid-phase epitaxial crystallisation of depth dependent Ge{sub x}Si{sub lx} alloy layers produced by implanting Ge into Si substrates was studied. In-situ monitoring was done using time-resolved reflectivity (TRR) whilst post-anneal defect structures were characterised by Rutherford backscattering and channeling spectrometry (RBS-C) and transmission electron microscopy (TEM). Particular attention was directed at Ge concentrations above the critical concentration for the growth of fully strained layers. Strain relief is shown to be correlated with a sudden reduction in crystallisation velocity caused by roughening of the crystalline/amorphous interface. 11 refs., 1 tab., 2 figs.

  16. Strain relaxation during solid-phase epitaxial crystallisation of Ge{sub x}Si{sub 1-x} alloy layers with depth dependent G{sub e} compositions

    Energy Technology Data Exchange (ETDEWEB)

    Wong, Wahchung; Elliman, R.G.; Kringhoj, P. [Australian National Univ., Canberra, ACT (Australia). Research School of Physical Sciences

    1993-12-31

    The solid-phase epitaxial crystallisation of depth dependent Ge{sub x}Si{sub lx} alloy layers produced by implanting Ge into Si substrates was studied. In-situ monitoring was done using time-resolved reflectivity (TRR) whilst post-anneal defect structures were characterised by Rutherford backscattering and channeling spectrometry (RBS-C) and transmission electron microscopy (TEM). Particular attention was directed at Ge concentrations above the critical concentration for the growth of fully strained layers. Strain relief is shown to be correlated with a sudden reduction in crystallisation velocity caused by roughening of the crystalline/amorphous interface. 11 refs., 1 tab., 2 figs.

  17. Structural and functional analysis of the S-layer protein crystallisation domain of Lactobacillus acidophilus ATCC 4356 : evidence for protein : protein interaction of two subdomains

    NARCIS (Netherlands)

    Smit, E.; Jager, D.; Martinez, B.; Tielen, F.J.; Pouwels, P.H.

    2002-01-01

    The structure of the crystallisation domain, SAN, of the S A-protein of Lactobacillus acidophilus ATCC 4356 was analysed by insertion and deletion mutagenesis, and by proteolytic treatment. Mutant S A-protein synthesised in Escherichia coli with 7-13 amino acid insertions near the N terminus or

  18. Atmospheric Research 2011 Technical Highlights

    Science.gov (United States)

    2012-01-01

    The 2011 Technical Highlights describes the efforts of all members of Atmospheric Research. Their dedication to advancing Earth Science through conducting research, developing and running models, designing instruments, managing projects, running field campaigns, and numerous other activities, is highlighted in this report.

  19. Highlights of nuclear chemistry 1995

    International Nuclear Information System (INIS)

    1996-07-01

    In this report 9 topics of the work of the Nuclear Chemistry Group in 1995 are highlighted. A list of publications and an overview of the international cooperation is given. (orig.). 19 refs., 19 figs., 2 tabs., 2 app

  20. Highlights of nuclear chemistry 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    In this report 9 topics of the work of the Nuclear Chemistry Group in 1995 are highlighted. A list of publications and an overview of the international cooperation is given. (orig.). 19 refs., 19 figs., 2 tabs., 2 app.

  1. LAMA Preconference and Program Highlights.

    Science.gov (United States)

    Library Administration & Management, 1988

    1988-01-01

    Highlights events of the Library Administration and Management Association 1988 conference, including presentation of awards and programs on: (1) transfer of training; (2) hiring; (3) mentoring; (4) acquisitions automation; (5) library building consultation; and (6) managing shared systems. (MES)

  2. Research and technology highlights, 1993

    Science.gov (United States)

    1994-01-01

    This report contains highlights of the major accomplishments and applications that have been made by Langley researchers and by our university and industry colleagues during the past year. The highlights illustrate both the broad range of the research and technology activities supported by NASA Langley Research Center and the contributions of this work toward maintaining United States leadership in aeronautics and space research. This report also describes some of the Center's most important research and testing facilities.

  3. Brookhaven highlights, 1986-1987

    International Nuclear Information System (INIS)

    Rowe, M.S.

    1988-01-01

    The highlights of research conducted between October 1985 and September 1987 at Brookhaven National Laboratory are reviewed in this publication. Also covered are the administrative and financial status of the laboratory and a brief mention of meetings held and honors received. (FI)

  4. A 125Te and 23Na NMR investigation of the structure and crystallisation of sodium tellurite glasses.

    Science.gov (United States)

    Holland, D; Bailey, J; Ward, G; Turner, B; Tierney, P; Dupree, R

    2005-01-01

    125Te static nuclear magnetic resonance (NMR) and 23Na and 125Te magic angle spinning (MAS) NMR have been used, in conjunction with X-ray diffraction, to examine the structure and crystallisation behaviour of glasses of composition xNa2O.(1-x)TeO2 (0.075 x 0.4). The MAS NMR 23Na spectra from the glasses are broad and featureless but shift by approximately +5 ppm with increased x, i.e. as the system becomes more ionic. The static 125Te NMR spectra show an increase in axial symmetry with increasing x, indicating a shift from predominantly [TeO4] to [TeO3] structural units. The 23Na and 125Te spectra from the crystallised samples have been fitted to obtain information on the sites in the metastable crystal phases, which are the first to form on heating and which are therefore more closely related to the glass structure than thermodynamically stable crystal phases. New sodium tellurite phases are reported, including a sodium stabilised, face centred cubic phase related to delta-TeO2; a metastable form of Na2Te4O9 containing 3 sodium and 4 tellurium sites; and a metastable form of Na2Te2O5 containing 2 sodium sites. There is evidence of oxidation of TeIV to TeVI occurring in glasses with high values of x and, at x=0.40 and 0.50 (outside the glass forming range), some sodium metatellurate (Na2TeO4) is formed at the same time as sodium metatellurite (Na2TeO3). The 125Te shift is very sensitive to environment within the sodium tellurite system, covering more than 320 ppm, with anisotropies varying from 640 to 1540 ppm. The lack of features in the 125Te spectra of the glass phases, combined with the large shift range and high but variable anisotropy, means than it is not possible to obtain a unique fit to any presumed species present. Furthermore, the chemical shift anisotropy parameters for three of the four Te sites in the Na2Te4O9 phase are found to lie outside the range used for previous simulations of glass spectra.

  5. Inhibition of surface crystallisation of amorphous indomethacin particles in physical drug-polymer mixtures

    DEFF Research Database (Denmark)

    Priemel, Petra A; Laitinen, Riikka; Barthold, Sarah

    2013-01-01

    stability than pure IMC whereas IMC Soluplus(®) mixtures did not. Water uptake was higher for mixtures containing Soluplus(®) than for amorphous IMC or IMC Eudragit(®) mixtures. However, the Tg of amorphous IMC was unaffected by the presence (and nature) of polymer. SEM revealed that Eudragit(®) particles...... through reduced IMC surface molecular mobility. Polymer particles may also mechanically hinder crystal growth outwards from the surface. This work highlights the importance of microparticulate surface coverage of amorphous drug particles on their stability....

  6. Energy Policy. Highlights. 2013 Edition

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-01

    Energy Policy Highlights showcases recent developments in energy policies among all 28 IEA member countries. Each contribution underscores the changing nature of both global and domestic energy challenges, as well as the commonality of energy concerns among member countries. The policies highlighted in this publication identify an urgent need to reduce greenhouse gas (GHG) emissions as a clear policy objective. Electricity, enhancing energy efficiency and increasing the share of renewables in the energy mix in a cost effective manner are likewise areas of common focus. On the end-user side, increasing public awareness of domestic energy policies through improved transparency and engagement is an important facet of policy support among IEA member countries. The successful implementation of policies and other initiatives benefitted from efforts to inform the public.

  7. Highlights of nuclear chemistry 1994

    International Nuclear Information System (INIS)

    1994-12-01

    Highlights were: 1. Fission product release: benchmark calculations for severe nuclear accidents; 2. Thermochemical data for reactor materials and fission products; 3. thermochemical calculations on fuel of the high-temperature gas-cooled reactor; 4. Formation of organic tellurides during nuclear accidents?; 5. Reaction of tellurium with Zircaloy-4; 6. Transmutation of fission products; 7. The thermal conductivity of high-burnup UO 2 fuel; 8. Tritium retention in graphite. (orig./HP)

  8. Tourette syndrome research highlights 2015

    Science.gov (United States)

    Richards, Cheryl A.; Black, Kevin J.

    2016-01-01

    We present selected highlights from research that appeared during 2015 on Tourette syndrome and other tic disorders. Topics include phenomenology, comorbidities, developmental course, genetics, animal models, neuroimaging, electrophysiology, pharmacology, and treatment. We briefly summarize articles whose results we believe may lead to new treatments, additional research or modifications in current models of TS. PMID:27429744

  9. LHC Results Highlights (CLASHEP 2013)

    CERN Document Server

    Gonzalez, O.

    2015-05-22

    The good performance of the LHC provided enough data at 7 TeV and 8 TeV to allow the experiments to perform very competitive measurements and to expand the knowledge about the fundamental interaction far beyond that from previous colliders. This report summarizes the highlights of the results obtained with these data samples by the four large experiments, covering all the topics of the physics program and focusing on those exploiting the possibilities of the LHC.

  10. A low viscosity, low boiling point, clean solvent system for the rapid crystallisation of highly specular perovskite films

    Energy Technology Data Exchange (ETDEWEB)

    Noel, Nakita K.; Habisreutinger, Severin N.; Wenger, Bernard; Klug, Matthew T.; Hörantner, Maximilian T.; Johnston, Michael B.; Nicholas, Robin J.; Moore, David T.; Snaith, Henry J.

    2017-01-01

    Perovskite-based photovoltaics have, in recent years, become poised to revolutionise the solar industry. While there have been many approaches taken to the deposition of this material, one-step spin-coating remains the simplest and most widely used method in research laboratories. Although spin-coating is not recognised as the ideal manufacturing methodology, it represents a starting point from which more scalable deposition methods, such as slot-dye coating or ink-jet printing can be developed. Here, we introduce a new, low-boiling point, low viscosity solvent system that enables rapid, room temperature crystallisation of methylammonium lead triiodide perovskite films, without the use of strongly coordinating aprotic solvents. Through the use of this solvent, we produce dense, pinhole free films with uniform coverage, high specularity, and enhanced optoelectronic properties. We fabricate devices and achieve stabilised power conversion efficiencies of over 18% for films which have been annealed at 100 degrees C, and over 17% for films which have been dried under vacuum and have undergone no thermal processing. This deposition technique allows uniform coating on substrate areas of up to 125 cm2, showing tremendous promise for the fabrication of large area, high efficiency, solution processed devices, and represents a critical step towards industrial upscaling and large area printing of perovskite solar cells.

  11. Improved conductivity in dye-sensitised solar cells through block-copolymer confined TiO 2 crystallisation

    KAUST Repository

    Guldin, Stefan

    2011-01-01

    Anatase TiO2 is typically a central component in high performance dye-sensitised solar cells (DSCs). This study demonstrates the benefits of high temperature synthesised mesoporous titania for the performance of solid-state DSCs. In contrast to earlier methods, the high temperature stability of mesoporous titania is enabled by the self-assembly of the amphiphilic block copolymer polyisoprene-block-polyethylene oxide (PI-b -PEO) which compartmentalises TiO2 crystallisation, preventing the collapse of porosity at temperatures up to 700 °C. The systematic study of the temperature dependence on DSC performance reveals a parameter trade-off: high temperature annealed anatase consisted of larger crystallites and had a higher conductivity, but this came at the expense of a reduced specific surface area. While the reduction in specific surface areas was found to be detrimental for liquid-electrolyte DSC performance, solid-state DSCs benefitted from the increased anatase conductivity and exhibited a performance increase by a factor of three. © 2011 The Royal Society of Chemistry.

  12. Performance potential of low-defect density silicon thin-film solar cells obtained by electron beam evaporation and laser crystallisation

    Directory of Open Access Journals (Sweden)

    Kim K. H.

    2013-01-01

    Full Text Available A few microns thick silicon films on glass coated with a dielectric intermediate layer can be crystallised by a single pass of a line-focused diode laser beam. Under favorable process conditions relatively large linear grains with low defect density are formed. Most grain boundaries are defect-free low-energy twin-boundaries. Boron-doped laser crystallised films are processed into solar cells by diffusing an emitter from a phosphorous spin-on-dopant source, measuring up to 539 mV open-circuit voltage prior to metallisation. After applying a point-contact metallisation the best cell achieves 7.8% energy conversion efficiency, open-circuit voltage of 526 mV and short-circuit current of 26 mA/cm2. The efficiency is significantly limited by a low fill-factor of 56% due to the simplified metallisation approach. The internal quantum efficiency of laser crystallised cells is consistent with low front surface recombination. By improving cell metallisation and enhancing light-trapping the efficiencies of above 13% can be achieved.

  13. Atmospheric Research 2012 Technical Highlights

    Science.gov (United States)

    Lau, William K -M.

    2013-01-01

    This annual report, as before, is intended for a broad audience. Our readers include colleagues within NASA, scientists outside the Agency, science graduate students, and members of the general public. Inside are descriptions of atmospheric research science highlights and summaries of our education and outreach accomplishments for calendar year 2012.The report covers research activities from the Mesoscale Atmospheric Processes Laboratory, the Climate and Radiation Laboratory, the Atmospheric Chemistry and Dynamics Laboratory, and the Wallops Field Support Office under the Office of Deputy Director for Atmospheres, Earth Sciences Division in the Sciences and Exploration Directorate of NASAs Goddard Space Flight Center. The overall mission of the office is advancing knowledge and understanding of the Earths atmosphere. Satellite missions, field campaigns, peer-reviewed publications, and successful proposals are essential to our continuing research.

  14. The significance of the amorphous potential energy landscape for dictating glassy dynamics and driving solid-state crystallisation.

    Science.gov (United States)

    Ruggiero, Michael T; Krynski, Marcin; Kissi, Eric Ofosu; Sibik, Juraj; Markl, Daniel; Tan, Nicholas Y; Arslanov, Denis; van der Zande, Wim; Redlich, Britta; Korter, Timothy M; Grohganz, Holger; Löbmann, Korbinian; Rades, Thomas; Elliott, Stephen R; Zeitler, J Axel

    2017-11-15

    The fundamental origins surrounding the dynamics of disordered solids near their characteristic glass transitions continue to be fiercely debated, even though a vast number of materials can form amorphous solids, including small-molecule organic, inorganic, covalent, metallic, and even large biological systems. The glass-transition temperature, T g , can be readily detected by a diverse set of techniques, but given that these measurement modalities probe vastly different processes, there has been significant debate regarding the question of why T g can be detected across all of them. Here we show clear experimental and computational evidence in support of a theory that proposes that the shape and structure of the potential-energy surface (PES) is the fundamental factor underlying the glass-transition processes, regardless of the frequency that experimental methods probe. Whilst this has been proposed previously, we demonstrate, using ab initio molecular-dynamics (AIMD) simulations, that it is of critical importance to carefully consider the complete PES - both the intra-molecular and inter-molecular features - in order to fully understand the entire range of atomic-dynamical processes in disordered solids. Finally, we show that it is possible to utilise this dependence to directly manipulate and harness amorphous dynamics in order to control the behaviour of such solids by using high-powered terahertz pulses to induce crystallisation and preferential crystal-polymorph growth in glasses. Combined, these findings provide compelling evidence that the PES landscape, and the corresponding energy barriers, are the ultimate controlling feature behind the atomic and molecular dynamics of disordered solids, regardless of the frequency at which they occur.

  15. Highlights of DAMA/LIBRA

    Directory of Open Access Journals (Sweden)

    Bernabei R.

    2016-01-01

    Full Text Available The DAMA project develops and uses new/improved low background scintillation detectors to investigate the Dark Matter (DM particle component(s in the galactic halo and rare processes deep underground at the Gran Sasso National Laboratory (LNGS of the I.N.F.N.. Here some highlights of DAMA/LIBRA (Large sodium Iodide Bulk for Rare processes as a unique apparatus in direct DM investigation for its full sensitive mass, target material, intrinsic radio-purity, methodological approach and all the controls performed on the experimental parameters are outlined. The DAMA/LIBRA–phase1 and the former DAMA/NaI data (cumulative exposure 1.33 ton × yr, corresponding to 14 annual cycles have reached a model-independent evidence at 9.3 σ C.L. for the presence of DM particles in the galactic halo exploiting the DM annual modulation signature with highly radio-pure NaI(Tl target. Some of the perspectives of the presently running DAMA/LIBRA–phase2 are summarised and the powerful tools offered by a model independent strategy of DM investigation are pointed out.

  16. ESO PR Highlights in 2000

    Science.gov (United States)

    2001-01-01

    At the beginning of the new millennium, ESO and its staff are facing the future with confidence. The four 8.2-m Unit Telescopes of the Very Large Telescope (VLT) are in great shape and the VLT Interferometer (VLTI) will soon have "first fringes". The intercontinental ALMA project is progressing well and concepts for extremely large optical/infrared telescopes are being studied. They can also look back at a fruitful and rewarding past year. Perhaps the most important, single development has been the rapid transition of the Very Large Telescope (VLT). From being a "high-tech project under construction" it has now become a highly proficient, world-class astronomical observatory. This trend is clearly reflected in ESO's Press Releases , as more and more front-line scientific results emerge from rich data obtained at this very efficient facility. There were also exciting news from several of the instruments at La Silla. At the same time, the ESO community may soon grow, as steps towards membership are being taken by various European countries. Throughout 2000, a total of 54 PR communications were made, with a large number of Press Photos and Video Clips, cf. the 2000 PR Index. Some of the ESO PR highlights may be accessed directly via the clickable image on the present page. ESO PR Photo 01/01 is also available in a larger (non-clickable) version [ JPEG: 566 x 566 pix - 112k]. It may be reproduced, if credit is given to the European Southern Observatory.

  17. Cassini's Grand Finale Science Highlights

    Science.gov (United States)

    Spilker, Linda

    2017-10-01

    After 13 years in orbit, the Cassini-Huygens Mission to Saturn ended in a science-rich blaze of glory. Cassini returned its final bits of unique science data on September 15, 2017, as it plunged into Saturn's atmosphere satisfying planetary protection requirements. Cassini's Grand Finale covered a period of roughly five months and ended with the first time exploration of the region between the rings and planet.The final close flyby of Titan in late April 2017 propelled Cassini across Saturn’s main rings and into its Grand Finale orbits; 22 orbits that repeatedly dove between Saturn’s innermost rings and upper atmosphere making Cassini the first spacecraft to explore this region. The last orbit turned the spacecraft into the first Saturn upper atmospheric probe.The Grand Finale orbits provided highest resolution observations of both the rings and Saturn, and in-situ sampling of the ring particle composition, Saturn's atmosphere, plasma, and innermost radiation belts. The gravitational field was measured to unprecedented accuracy, providing information on the interior structure of the planet, winds in the deeper atmosphere, and mass of the rings. The magnetic field provided insight into the physical nature of the magnetic dynamo and structure of the internal magnetic field. The ion and neutral mass spectrometer sampled the upper atmosphere for molecules that escape the atmosphere in addition to molecules originating from the rings. The cosmic dust analyzer directly sampled the composition from different parts of the main rings for the first time. Fields and particles instruments directly measured the plasma environment between the rings and planet.Science highlights and new mysteries gleaned to date from the Grand Finale orbits will be discussed.The research described in this paper was carried out in part at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. Copyright 2017

  18. Atmospheric Research 2014 Technical Highlights

    Science.gov (United States)

    Platnick, Steven

    2015-01-01

    Earth Sciences Division in atmospheric science research. Figure 1.1 shows the 20-year record of peer-reviewed publications and proposals among the various Laboratories. This data shows that the scientific work being conducted in the Laboratories is competitive with the work being done elsewhere in universities and other government agencies. The office of Deputy Director for Atmospheric Research will strive to maintain this record by rigorously monitoring and promoting quality while emphasizing coordination and integration among atmospheric disciplines. Also, an appropriate balance will be maintained between the scientists' responsibility for large collaborative projects and missions and their need to carry out active science research as a principal investigator. This balance allows members of the Laboratories to improve their scientific credentials, and develop leadership potentials. Interdisciplinary research is carried out in collaboration with other laboratories and research groups within the Earth Sciences Division, across the Sciences and Exploration Directorate, and with partners in universities and other government agencies. Members of the Laboratories interact with the general public to support a wide range of interests in the atmospheric sciences. Among other activities, the Laboratories raise the public's awareness of atmospheric science by presenting public lectures and demonstrations, by making scientific data available to wide audiences, by teaching, and by mentoring students and teachers. The Atmosphere Laboratories make substantial efforts to attract and recruit new scientists to the various areas of atmospheric research. We strongly encourage the establishment of partnerships with Federal and state agencies that have operational responsibilities to promote the societal application of our science products. This report describes our role in NASA's mission, provides highlights of our research scope and activities, and summarizes our scientists' major

  19. The crystallisation of Cu2ZnSnS4 thin film solar cell absorbers from co-electroplated Cu-Zn-Sn precursors

    International Nuclear Information System (INIS)

    Schurr, R.; Hoelzing, A.; Jost, S.; Hock, R.; Voss, T.; Schulze, J.; Kirbs, A.; Ennaoui, A.; Lux-Steiner, M.; Weber, A.; Koetschau, I.; Schock, H.-W.

    2009-01-01

    The best CZTS solar cell so far was produced by co-sputtering continued with vapour phase sulfurization method. Efficiencies of up to 5.74% were reached by Katagiri et al. The one step electrochemical deposition of copper, zinc, tin and subsequent sulfurization is an alternative fabrication technique for the production of Cu 2 ZnSnS 4 based thin film solar cells. A kesterite based solar cell (size 0.5 cm 2 ) with a conversion efficiency of 3.4% (AM1.5) was produced by vapour phase sulfurization of co-electroplated Cu-Zn-Sn films. We report on results of in-situ X-ray diffraction (XRD) experiments during crystallisation of kesterite thin films from electrochemically co-deposited metal films. The kesterite crystallisation is completed by the solid state reaction of Cu 2 SnS 3 and ZnS. The measurements show two different reaction paths depending on the metal ratios in the as deposited films. In copper-rich metal films Cu 3 Sn and CuZn were found after electrodeposition. In copper-poor or near stoichiometric precursors additional Cu 6 Sn 5 and Sn phases were detected. The formation mechanism of Cu 2 SnS 3 involves the binary sulphides Cu 2-x S and SnS 2 in the absence of the binary precursor phase Cu 6 Sn 5 . The presence of Cu 6 Sn 5 leads to a preferred formation of Cu 2 SnS 3 via the reaction educts Cu 2-x S and SnS 2 in the presence of a SnS 2 (Cu 4 SnS 6 ) melt. The melt phase may be advantageous in crystallising the kesterite, leading to enhanced grain growth in the presence of a liquid phase

  20. ESO PR Highlights in 2006

    Science.gov (United States)

    2007-01-01

    Last year proved to be another exceptional year for the European organisation for ground-based astronomy. ESO should begin the New Year with two new member states: Spain (PR 05/06) and the Czech Republic (PR 52/06). ESO PR Highlights 2006 2006 was a year of renovation and revolution in the world of planets. A new Earth-like exoplanet has been discovered (PR 03/06) using a network of telescopes from all over the world (including the Danish 1.54-m one at ESO La Silla). It is not the only child of this fruitful year: thanks to the combined use of ESO's Very Large Telescope (VLT) and La Silla instruments, a surprising system of twin giant exoplanets was found (PR 29/06), and a trio of Neptune-like planets hosted by a nearby star were identified (PR 18/06). These results open new perspectives on the search for habitable zones and on the understanding of the mechanism of planet formation. The VISIR instrument on the VLT has been providing unique information to answer this last question, by supplying a high resolution view of a planet-forming disc (PR 36/06). There are not only new members in the planets' register: during the General Assembly of the International Astronomical Union held in Prague (Czech Republic), it was decided that Pluto is not a planet anymore but a 'dwarf planet'. Whatever its status, Pluto still has a satellite, Charon, whose radius and density have been measured more accurately by observing a rare occultation from different sites, including Cerro Paranal (PR 02/06). The scientific community dedicated 2006 to the great physicist James Clerk Maxwell (it was the 175th anniversary of the birth): without his electromagnetic theory of light, none of the astonishing discoveries of modern physics could have been achieved. Nowadays we can look at distant galaxies in great detail: the GIRAFFE spectrograph on the VLT revealed that galaxies 6 billion years ago had the same amount of dark matter relative to stars than nowadays (PR 10/06), while SINFONI gave an

  1. Digestion Fractional Crystallisation (DFC)

    DEFF Research Database (Denmark)

    Pilbeam, Llewellyn Howard; Nielsen, T.F.D.; Waight, Tod Earle

    2013-01-01

    High-precision electron microprobe data for major and trace elements (nickel, calcium and manganese) in the margins and rims of groundmass olivine grains from the Majuagaa kimberlite (sensu stricto) in southern West Greenland are presented. Despite a range of olivine core compositions defining...

  2. The crystallisation of Cu{sub 2}ZnSnS{sub 4} thin film solar cell absorbers from co-electroplated Cu-Zn-Sn precursors

    Energy Technology Data Exchange (ETDEWEB)

    Schurr, R. [Chair for Crystallography and Structural Physics, University of Erlangen-Nuernberg, Staudtstrasse 3, D-91058 Erlangen (Germany)], E-mail: schurr@krist.uni-erlangen.de; Hoelzing, A.; Jost, S.; Hock, R. [Chair for Crystallography and Structural Physics, University of Erlangen-Nuernberg, Staudtstrasse 3, D-91058 Erlangen (Germany); Voss, T.; Schulze, J.; Kirbs, A. [Atotech Deutschland GmbH, Erasmusstrasse 20, D-10553 Berlin (Germany); Ennaoui, A.; Lux-Steiner, M. [Heterogeneous Material Systems SE II, Hahn-Meitner-Institut, Glienickerstr.100, D-14109 Berlin (Germany); Weber, A.; Koetschau, I.; Schock, H.-W. [Technology SE III, Hahn-Meitner-Institut, Glienickerstr.100, D-14109 Berlin (Germany)

    2009-02-02

    The best CZTS solar cell so far was produced by co-sputtering continued with vapour phase sulfurization method. Efficiencies of up to 5.74% were reached by Katagiri et al. The one step electrochemical deposition of copper, zinc, tin and subsequent sulfurization is an alternative fabrication technique for the production of Cu{sub 2}ZnSnS{sub 4} based thin film solar cells. A kesterite based solar cell (size 0.5 cm{sup 2}) with a conversion efficiency of 3.4% (AM1.5) was produced by vapour phase sulfurization of co-electroplated Cu-Zn-Sn films. We report on results of in-situ X-ray diffraction (XRD) experiments during crystallisation of kesterite thin films from electrochemically co-deposited metal films. The kesterite crystallisation is completed by the solid state reaction of Cu{sub 2}SnS{sub 3} and ZnS. The measurements show two different reaction paths depending on the metal ratios in the as deposited films. In copper-rich metal films Cu{sub 3}Sn and CuZn were found after electrodeposition. In copper-poor or near stoichiometric precursors additional Cu{sub 6}Sn{sub 5} and Sn phases were detected. The formation mechanism of Cu{sub 2}SnS{sub 3} involves the binary sulphides Cu{sub 2-x}S and SnS{sub 2} in the absence of the binary precursor phase Cu{sub 6}Sn{sub 5}. The presence of Cu{sub 6}Sn{sub 5} leads to a preferred formation of Cu{sub 2}SnS{sub 3} via the reaction educts Cu{sub 2-x}S and SnS{sub 2} in the presence of a SnS{sub 2}(Cu{sub 4}SnS{sub 6}) melt. The melt phase may be advantageous in crystallising the kesterite, leading to enhanced grain growth in the presence of a liquid phase.

  3. Crystallisation of mela-aillikites of the Narsaq region, Gardar alkaline province, south Greenland and relationships to other aillikitic carbonatitic associations in the province

    Science.gov (United States)

    Upton, B. G. J.; Craven, J. A.; Kirstein, L. A.

    2006-11-01

    Aillikites (carbonated, melilite-free ultramafic lamprophyres grading to carbonatites) are minor components of the Gardar alkaline igneous province. They occur principally as minor intrusions and as clasts in diatremes, but more voluminous aillikitic intrusions crop out near the Ilímaussaq Complex, which they predate by a few million years. These larger intrusions were emplaced at 1160 ± 5 Ma. They are essentially carbonate-free and, consisting almost wholly of ferromagnesian silicate and oxide minerals, are mela-aillikites. Typically the mela-aillikites are fine-grained rocks composed largely of olivine, clinopyroxene, phlogopite and magnetite that crystallised in open systems, permitting loss of volatile-rich residues. The petrography is highly complex, involving at least 28 mineral species. Pyroxenitic veins were emplaced while the host-rocks were still at high temperatures and represent channels through which fluorinated silico-carbonatitic residual melts escaped, with exsolving CO 2 as propellant. Precipitation of Ca-rich minerals including monticellite, perovskite, vesuvianite, wollastonite and cuspidine was a result of dissociation of the calcium carbonate in the residual melts. Late-stage crystallisation was in a highly oxidising environment in which the 'common minerals' attain extreme compositions (almost pure forsterite, ferrian-diopside, highly magnesian ilmenite, Ba-Ti-rich phlogopite and Sr-rich kaersutite). Spatially associated diatremes may be vents through which CO 2-rich gases erupted. The whole-rock compositions are considered to be well removed from those of co-existing melts: compaction and expulsion of highly mobile residual melts is inferred to have left the mela-aillikites as aberrant cumulates. The mela-aillikites are a late-Gardar manifestation of the aillikitic magmatism that occurred intermittently in the province for over 120 Ma. Repetitive formation of metasomite vein systems in the deep lithospheric mantle is postulated. These

  4. Crystallisation kinetics of amorphous Fe72.5-xCu1Nb4.5Si10+x+yB12-y alloy

    International Nuclear Information System (INIS)

    Miglierini, M.; Lipka, J.; Sitek, J.

    1994-01-01

    Fe 73.5 Cu 1 Nb 3 Si 13.5 B 9 and Fe 72.5-x Cu 1 Nb 4.5 Si 10+x+y B 12-y alloys are compared from the point of view of crystallisation behaviour and changes in the short-range order in the amorphous reminder. The increase in Nb to 4.5 at.% in the latter system slows down the formation of nanocrystals to approximately 40% even after 16 hours of anneal at 550 C for x = 0.5, y = 3. Segregation-induced changes in the short-range order are manifested via hyperfine field distributions corresponding to the amorphous reminder. (orig.)

  5. Using an Electronic Highlighter to Eliminate the Negative Effects of Pre-Existing, Inappropriate Highlighting

    Science.gov (United States)

    Gier, Vicki; Kreiner, David; Hudnell, Jason; Montoya, Jodi; Herring, Daniel

    2011-01-01

    The purpose of the present experiment was to determine whether using an active learning technique, electronic highlighting, can eliminate the negative effects of pre-existing, poor highlighting on reading comprehension. Participants read passages containing no highlighting, appropriate highlighting, or inappropriate highlighting. We hypothesized…

  6. Photon science 2012. Highlights and annual report

    International Nuclear Information System (INIS)

    Appel, Karen; Gehrke, Rainer; Gutt, Christian; Incoccia-Hermes, Lucia; Laarmann, Tim; Morgenroth, Wolfgang; Roehlsberger, Ralf; Schulte-Schrepping, Horst; Vainio, Ulla; Zimmermann, Martin von

    2012-12-01

    The synchrotron-radiation research at DESY is reviewed. The following topics are dealt with: Research highlights, research platforms and outstations, light sources, new technologies and developments. (HSI)

  7. Editorial highlighting and highly cited papers

    Science.gov (United States)

    Antonoyiannakis, Manolis

    Editorial highlighting-the process whereby journal editors select, at the time of publication, a small subset of papers that are ostensibly of higher quality, importance or interest-is by now a widespread practice among major scientific journal publishers. Depending on the venue, and the extent to which editorial resources are invested in the process, highlighted papers appear as News & Views, Research Highlights, Perspectives, Editors' Choice, IOP Select, Editors' Summary, Spotlight on Optics, Editors' Picks, Viewpoints, Synopses, Editors' Suggestions, etc. Here, we look at the relation between highlighted papers and highly influential papers, which we define at two levels: having received enough citations to be among the (i) top few percent of their journal, and (ii) top 1% of all physics papers. Using multiple linear regression and multilevel regression modeling we examine the parameters associated with highly influential papers. We briefly comment on cause and effect relationships between citedness and highlighting of papers.

  8. Using Highlighting to Train Attentional Expertise.

    Science.gov (United States)

    Roads, Brett; Mozer, Michael C; Busey, Thomas A

    2016-01-01

    Acquiring expertise in complex visual tasks is time consuming. To facilitate the efficient training of novices on where to look in these tasks, we propose an attentional highlighting paradigm. Highlighting involves dynamically modulating the saliency of a visual image to guide attention along the fixation path of a domain expert who had previously viewed the same image. In Experiment 1, we trained naive subjects via attentional highlighting on a fingerprint-matching task. Before and after training, we asked subjects to freely inspect images containing pairs of prints and determine whether the prints matched. Fixation sequences were automatically scored for the degree of expertise exhibited using a Bayesian discriminative model of novice and expert gaze behavior. Highlighted training causes gaze behavior to become more expert-like not only on the trained images but also on transfer images, indicating generalization of learning. In Experiment 2, to control for the possibility that the increase in expertise is due to mere exposure, we trained subjects via highlighting of fixation sequences from novices, not experts, and observed no transition toward expertise. In Experiment 3, to determine the specificity of the training effect, we trained subjects with expert fixation sequences from images other than the one being viewed, which preserves coarse-scale statistics of expert gaze but provides no information about fine-grain features. Observing at least a partial transition toward expertise, we obtain only weak evidence that the highlighting procedure facilitates the learning of critical local features. We discuss possible improvements to the highlighting procedure.

  9. AEB-highlights. January - June 1977

    International Nuclear Information System (INIS)

    1977-01-01

    AEB Highlights is a half-yearly report reflecting the most important recent achievements of the various Research and Technical divisions of the Atomic Energy Board. It appears alternatively in English and Afrikaans [af

  10. Using Highlighting to Train Attentional Expertise.

    Directory of Open Access Journals (Sweden)

    Brett Roads

    Full Text Available Acquiring expertise in complex visual tasks is time consuming. To facilitate the efficient training of novices on where to look in these tasks, we propose an attentional highlighting paradigm. Highlighting involves dynamically modulating the saliency of a visual image to guide attention along the fixation path of a domain expert who had previously viewed the same image. In Experiment 1, we trained naive subjects via attentional highlighting on a fingerprint-matching task. Before and after training, we asked subjects to freely inspect images containing pairs of prints and determine whether the prints matched. Fixation sequences were automatically scored for the degree of expertise exhibited using a Bayesian discriminative model of novice and expert gaze behavior. Highlighted training causes gaze behavior to become more expert-like not only on the trained images but also on transfer images, indicating generalization of learning. In Experiment 2, to control for the possibility that the increase in expertise is due to mere exposure, we trained subjects via highlighting of fixation sequences from novices, not experts, and observed no transition toward expertise. In Experiment 3, to determine the specificity of the training effect, we trained subjects with expert fixation sequences from images other than the one being viewed, which preserves coarse-scale statistics of expert gaze but provides no information about fine-grain features. Observing at least a partial transition toward expertise, we obtain only weak evidence that the highlighting procedure facilitates the learning of critical local features. We discuss possible improvements to the highlighting procedure.

  11. Impact of crystallisation processes on depth profile formation in sol-gel PbZr.sub.0·52./sub.Ti.sub.0·48./sub.O.sub.3./sub. thin films

    Czech Academy of Sciences Publication Activity Database

    Aulika, I.; Mergen, S.; Bencan, A.; Zhang, Q.; Dejneka, Alexandr; Kosec, M.; Kundzins, K.; Demarchi, D.; Civera, P.

    2013-01-01

    Roč. 112, č. 1 (2013), s. 53-58 ISSN 1743-6753 R&D Projects: GA TA ČR TA01010517; GA ČR GAP108/12/1941 Institutional research plan: CEZ:AV0Z10100522 Keywords : compositional and optical gradien * PZT * spectroscopic ellipsometry * crystallisation proces * sol-gel * XRD * thin films * depth profile * spectroscopic elipsometry Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.107, year: 2013

  12. Influence of 1D and 2D Carbon Fillers and Their Functionalisation on Crystallisation and Thermomechanical Properties of Injection Moulded Nylon 6,6 Nanocomposites

    Directory of Open Access Journals (Sweden)

    Fabiola Navarro-Pardo

    2014-01-01

    Full Text Available Carbon nanotubes (CNTs and graphene were used as reinforcing fillers in nylon 6,6 in order to obtain nanocomposites by using an injection moulding process. The two differently structured nanofillers were used in their pristine or reduced form, after oxidation treatment and after amino functionalisation. Three low nanofiller contents were employed. Crystallisation behaviour and perfection of nylon 6,6 crystals were determined by differential scanning calorimetry and wide angle X-ray diffraction, respectively. Crystallinity was slightly enhanced in most samples as the content of the nanofillers was increased. The dimensionality of the materials was found to provide different interfaces and therefore different features in the nylon 6,6 crystal growth resulting in improved crystal perfection. Dynamical, mechanical analysis showed the maximum increases provided by the two nanostructures correspond to the addition of 0.1 wt.% amino functionalised CNTs, enhancing in 30% the storage modulus and the incorporation of 0.5 wt.% of graphene oxide caused an increase of 44% in this property. The latter also provided better thermal stability when compared to pure nylon 6,6 under inert conditions. The superior properties of graphene nanocomposites were attributed to the larger surface area of the two-dimensional graphene compared to the one-dimensional CNTs.

  13. Crystallisation of Ba1-xSrxZn2Si2O7 from BaO/SrO/ZnO/SiO2 glass with different ZrO2 and TiO2 concentrations

    Science.gov (United States)

    Vladislavova, Liliya; Kracker, Michael; Zscheckel, Tilman; Thieme, Christian; Rüssel, Christian

    2018-04-01

    The effect of different nucleation agents such as ZrO2 and TiO2 was investigated for a first time with respect to their crystallisation behaviour in the glass system BaO-SrO-ZnO-SiO2. In all studied glasses, a Ba1-xSrxZn2Si2O7 (0.1 ≤ x ≤ 0.9) solid solution crystallized. This phase was first described in 2015 to possess a similar structure as the high temperature phase of BaZn2Si2O7 and a thermal expansion close to zero or even negative. It may find applications e.g. as cook panels, telescope mirrors, and furnace windows. Kinetic parameters of the crystallisation process were determined by supplying different heating rates in a differential scanning calorimeter (DSC). The results were evaluated using the equations of Ozawa and Kissinger with respect to the activation energies. Furthermore, the Ozawa method was used for the determination of Avrami parameters, which provides further information on the nucleation and crystallisation processes. Scanning electron microscopy including electron backscatter diffraction (EBSD) was used to characterise the microstructure, to determine the crystallite size and the crystal orientation. For the characterisation of the occurring crystalline phases, X-ray diffraction was used.

  14. Brookhaven highlights, October 1979-September 1980

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    Highlights are given for the research areas of the Brookhaven National Laboratory. These areas include high energy physics, physics and chemistry, life sciences, applied energy science (energy and environment, and nuclear energy), and support activities (including mathematics, instrumentation, reactors, and safety). (GHT)

  15. University of Maryland MRSEC - Research: Highlights

    Science.gov (United States)

    -Engineering Program: Project Lead the Way Thinking Small: Nanoscale Informal Science Education (NISE Education Outreach Highlights NanoFabulous Greatest Show on Earth: Big Top Physics, USA Science and Perspective at UMD MRSEC Nanoscience Camp Annual Middle School Student Science Conference (SSC) Pre

  16. Palliativedrugs.com therapeutic highlights: gabapentin

    Directory of Open Access Journals (Sweden)

    Twycross Robert

    2003-01-01

    Full Text Available This is the second in a series of highlights drawn from the www.palliativedrugs.com website. The website provides free access to the Palliative Care Formulary, a monthly newsletter and a bulletin board for advice to be given and received. With almost 10,000 professional members it is the largest palliative care resource of its kind.

  17. Brookhaven highlights, October 1979-September 1980

    International Nuclear Information System (INIS)

    1980-01-01

    Highlights are given for the research areas of the Brookhaven National Laboratory. These areas include high energy physics, physics and chemistry, life sciences, applied energy science (energy and environment, and nuclear energy), and support activities (including mathematics, instrumentation, reactors, and safety)

  18. Brookhaven highlights - Brookhaven National Laboratory 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-09-01

    This report highlights research conducted at Brookhaven National Laboratory in the following areas: alternating gradient synchrotron; physics; biology; national synchrotron light source; department of applied science; medical; chemistry; department of advanced technology; reactor; safety and environmental protection; instrumentation; and computing and communications.

  19. Highlighting relatedness promotes prosocial motives and behavior.

    Science.gov (United States)

    Pavey, Louisa; Greitemeyer, Tobias; Sparks, Paul

    2011-07-01

    According to self-determination theory, people have three basic psychological needs: relatedness, competence, and autonomy. Of these, the authors reasoned that relatedness need satisfaction is particularly important for promoting prosocial behavior because of the increased sense of connectedness to others that this engenders. In Experiment 1, the authors manipulated relatedness, autonomy, competence, or gave participants a neutral task, and found that highlighting relatedness led to higher interest in volunteering and intentions to volunteer relative to the other conditions. Experiment 2 found that writing about relatedness experiences promoted feelings of connectedness to others, which in turn predicted greater prosocial intentions. Experiment 3 found that relatedness manipulation participants donated significantly more money to charity than did participants given a neutral task. The results suggest that highlighting relatedness increases engagement in prosocial activities and are discussed in relation to the conflict and compatibility between individual and social outcomes. © 2011 by the Society for Personality and Social Psychology, Inc

  20. Trends and highlights of VCI 2004

    CERN Document Server

    Fabjan, Christian Wolfgang

    2004-01-01

    This report attempts to summarize the presentations given at this conference. Topics related to R&D of gaseous and solid state detectors clearly point to several trends in particle physics instrumentation. More established techniques are represented by reports on recent experiments and facilities which can be considered the highlights in this research field. The extension of these techniques to space, arctic ice and deep sea are opening new frontiers of particle physics.

  1. Highlights of LHC experiments – Part I

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00072301; The ATLAS collaboration

    2017-01-01

    The superb performance of the LHC accelerator in 2016, in both live time and peak luminosity, has provided a large data sample of collisions at 13 TeV. Excellent performances of the ATLAS and LHCb detectors, together with highly performant offline and analysis systems, mean that a wealth of results are already available from 13 TeV data. Selected highlights are reported here.

  2. ENC 2010 European nuclear congress - Conference highlights

    Energy Technology Data Exchange (ETDEWEB)

    Bonin, B. [European Nuclear Society (ENS), Bern (Switzerland)

    2010-11-15

    This synthetical paper presents the main progress, trends or achievements that have appeared through the 450 communications of this conference. The highlights are reported according to 11 issues: 1) general nuclear situation and policy, 2) life extension, 3) standardisation, 4) safety, 5) fuel cycle, 6) dismantling techniques and waste management, 7) research reactors, 8) fusion, 9) nuclear applications in life sciences, 10) education and training, 11) networks and research structures

  3. Highlights and Perspectives from the CMS Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Butler, Joel Nathan [Fermilab

    2017-09-09

    In 2016, the Large Hadron Collider provided proton-proton collisions at 13 TeV center-of-mass energy and achieved very high luminosity and reliability. The performance of the CMS Experiment in this running period and a selection of recent physics results are presented. These include precision measurements and searches for new particles. The status and prospects for data-taking in 2017 and a brief summary of the highlights of the High Luminosity (HL-LHC) upgrade of the CMS detector are also presented.

  4. Fermi GBM: Highlights from the First Year

    Science.gov (United States)

    Wilson-Hodge, Colleen A.

    2009-01-01

    The Fermi Gamma ray Burst Monitor is an all-sky instrument sensitive to photons from about 8 keV to 40 MeV. I will summarize highlights from the first year, including triggered observations of gamma ray bursts, soft gamma ray repeaters, and terrestrial gamma flashes, and observations in the continuous data of X-ray binaries and accreting X-ray pulsars. GBM provides complementary observations to Swift/BAT, observing many of the same sources, but over a wider energy range.

  5. Highlights of the SSC Site Development Plan

    International Nuclear Information System (INIS)

    Sanford, J.R.

    1991-10-01

    This paper summarizes highlights of the Site Development Plan for the Superconducting Super Collider Laboratory. The Plan, sometimes called a Master Plan, was prepared by the architectural and engineering firm for the Laboratory: Parsons Brinckerhoff/Morrison Knudsen (PB/MK) working in association with CRSS. Their task was to interpret the SSC project needs in the context of the Ellis County, Texas site. The team effort was under the direction of Lewis May from CRSS, guided by Robert Sims from the SSC Laboratory. Conceptual drawings are presented in this report

  6. Some physics highlights from the EUROBALL spectrometer

    International Nuclear Information System (INIS)

    Korten, W.

    2004-01-01

    The latest generation of large γ-ray spectrometers, such as EUROBALL, has boosted the explorations of nuclei under extreme conditions especially at the limits of angular momentum and at finite temperatures. But the coupling of this instrument to very selective ''ancillary'' devices allows for more and more refined investigations of the third important degree of freedom in contemporary nuclear-structure studies, the isospin. This contribution summarises some of the recent highlights from the physics at EUROBALL obtained in some of the different areas of nuclear-structure research

  7. Physics highlights at ILC and CLIC

    CERN Document Server

    Lukić, Strahinja

    2015-01-01

    In this lecture, the physics potential for the e+e- linear collider experiments ILC and CLIC is reviewed. The experimental conditions are compared to those at hadron colliders and their intrinsic value for precision experiments, complementary to the hadron colliders, is discussed. The detector concepts for ILC and CLIC are outlined in their most important aspects related to the precision physics. Highlights from the physics program and from the benchmark studies are given. It is shown that linear colliders are a promising tool, complementing the LHC in essential ways to test the Standard Model and to search for new physics.

  8. Biotransformation and bioactivation reactions - 2015 literature highlights.

    Science.gov (United States)

    Baillie, Thomas A; Dalvie, Deepak; Rietjens, Ivonne M C M; Cyrus Khojasteh, S

    2016-05-01

    Since 1972, Drug Metabolism Reviews has been recognized as one of the principal resources for researchers in pharmacological, pharmaceutical and toxicological fields to keep abreast of advances in drug metabolism science in academia and the pharmaceutical industry. With a distinguished list of authors and editors, the journal covers topics ranging from relatively mature fields, such as cytochrome P450 enzymes, to a variety of emerging fields. We hope to continue this tradition with the current compendium of mini-reviews that highlight novel biotransformation processes that were published during the past year. Each review begins with a summary of the article followed by our comments on novel aspects of the research and their biological implications. This collection of highlights is not intended to be exhaustive, but rather to be illustrative of recent research that provides new insights or approaches that advance the field of drug metabolism. Abbreviations NAPQI N-acetyl-p-benzoquinoneimine ALDH aldehyde dehydrogenase AO aldehyde oxidase AKR aldo-keto reductase CES carboxylesterase CSB cystathionine β-synthase CSE cystathionine γ-lyase P450 cytochrome P450 DHPO 2,3-dihydropyridin-4-one ESI electrospray FMO flavin monooxygenase GSH glutathione GSSG glutathione disulfide ICPMS inductively coupled plasma mass spectrometry i.p. intraperitoneal MDR multidrug-resistant NNAL 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol NNK 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone oaTOF orthogonal acceleration time-of-flight PBK physiologically based kinetic PCP pentachlorophenol SDR short-chain dehydrogenase/reductase SULT sulfotransferase TB tuberculosis.

  9. Syndicate of renewable energies - Highlights 2015

    International Nuclear Information System (INIS)

    2016-01-01

    This publication first proposes a presentation of the SER (Syndicat des Energies Renouvelables, Syndicate of Renewable Energies), a professional body: missions, scope of action, members. It outlines its commitment in the French policy for energy transition as a major actor of the sector of renewable energies. It addresses the legal and regulatory framework by indicating evolutions introduced by the French law for energy transition and for a green growth for the different renewable energies (hydroelectricity, wind energy, solar photovoltaic, geothermal, biofuels and bio-energies, biogas), by the new regimes of authorisations for onshore wind energy, methanization and hydroelectricity, and by the law for growth, activity and equality of economic opportunities. It proposes brief presentations of transverse actions (agreements, meetings, partnership in exhibitions, commitment in the COP21), and of actions regarding power grids, overseas territories, or the building sector. Some highlights related bio-energy sectors, geothermal energy, onshore wind energy, renewable marine energies and offshore wind energy, solar photovoltaic energy, hydroelectricity, or solar thermodynamic energy are mentioned. These highlights may concern legal, organisational, political or financial frameworks. Actions in the field of communication are indicated, and projects for 2016 are briefly indicated

  10. Astonishing the wild pigs highlights of technology

    CERN Document Server

    Trueb, Lucien F; Stuber, Fred A

    2015-01-01

    A hydraulic machine for astonishing wild pigs was one of the many technological highlights the author encountered in the course of his career as a research scientist and science writer. Writing a book about them, never taking more (or less) than two printed pages for each of 146 subjects was a very special challenge. The book covers fundamentally important achievements of technology that directly impacted mankind or even profoundly changed it. Many of those highlights are quite new, at least one of them (power generation by nuclear fusion) is not available yet. But particularly ingenious things dating way back were also included, as they are the base of our technical civilization Good examples are ceramics as well as copper, bronze and iron; whole periods of history have been named for the latter three. The analog computer of Antikythera used for stellar navigation was made some 2100 years ago, gunpowder was used in China as early as 1044 A.D., the astronomical clock in the Strasburg cathedral was built in th...

  11. FY 1996 Congressional budget request: Budget highlights

    Energy Technology Data Exchange (ETDEWEB)

    1995-02-01

    The FY 1996 budget presentation is organized by the Department`s major business lines. An accompanying chart displays the request for new budget authority. The report compares the budget request for FY 1996 with the appropriated FY 1995 funding levels displayed on a comparable basis. The FY 1996 budget represents the first year of a five year plan in which the Department will reduce its spending by $15.8 billion in budget authority and by $14.1 billion in outlays. FY 1996 is a transition year as the Department embarks on its multiyear effort to do more with less. The Budget Highlights are presented by business line; however, the fifth business line, Economic Productivity, which is described in the Policy Overview section, cuts across multiple organizational missions, funding levels and activities and is therefore included in the discussion of the other four business lines.

  12. Highlights from NuFact05

    CERN Multimedia

    CERN. Geneva; Landua, Rolf

    2005-01-01

    The 7th International Workshop on Neutrino Factories and Superbeams was held in Frascati in June 2005 with nearly 200 participants. The most recent progress in the design of future neutrino facilities was described, including novel ideas in detectors, and many issues were raised. The International Scoping Study (ISS) for a future Neutrino Facility which would incorporate a Neutrino Factory and/or a high intensity Neutrino Superbeam was launched at that occasion. Built upon previous studies in the USA, Europe and Japan, it will aim to i) define the physics case and a baseline design for such a facility including the related neutrino detection systems, ii) identify the required research and development programme and iii) perform comparisons with other options such as beta beams. The highlights of the meeting and the upcoming studies will be presented.

  13. Research highlights: impacts of microplastics on plankton.

    Science.gov (United States)

    Lin, Vivian S

    2016-02-01

    Each year, millions of metric tons of the plastic produced for food packaging, personal care products, fishing gear, and other human activities end up in lakes, rivers, and the ocean. The breakdown of these primary plastics in the environment results in microplastics, small fragments of plastic typically less than 1-5 mm in size. These synthetic particles have been detected in all of the world's oceans and also in many freshwater systems, accumulating in sediment, on shorelines, suspended in surface waters, and being ingested by plankton, fish, birds, and marine mammals. While the occurrence of plastics in surface waters has been surveyed in a number of studies, the impacts of microplastics on marine organisms are still being elucidated. This highlight features three recent publications that explore the interactions of microplastics with planktonic organisms to clarify the effects of these pollutants on some of the ocean's smallest and most important inhabitants.

  14. LHC INAUGURATION, LHC Fest highlights: exhibition time!

    CERN Multimedia

    2008-01-01

    David Gross, one of the twenty-one Nobel Laureates who have participated in the project.Tuesday 21 October 2008 Accelerating Nobels Colliding Charm, Atomic Cuisine, The Good Anomaly, A Quark Somewhere on the White Paper, Wire Proliferation, A Tale of Two Liquids … these are just some of the titles given to artworks by Physics Nobel Laureates who agreed to make drawings of their prize-winning discoveries (more or less reluctantly) during a special photo session. Science photographer Volker Steger made portraits of Physics Nobel Laureates and before the photo sessions he asked them to make a drawing of their most important discovery. The result is "Accelerating Nobels", an exhibition that combines unusual portraits of and original drawings by twenty-one Nobel laureates in physics whose work is closely related to CERN and the LHC. This exhibition will be one of the highlights of the LHC celebrations on 21 October in the SM18 hall b...

  15. Transport Task Force workshop: basic experiments highlights

    Energy Technology Data Exchange (ETDEWEB)

    Linford, R.K. (Los Alamos National Lab., NM (USA)); Luckhardt, S. (Massachusetts Inst. of Tech., Cambridge, MA (USA)); Lyon, J.F. (Oak Ridge National Lab., TN (USA)); Navratil, G.A. (Columbia Univ., New York, NY (USA)); Schoenberg, K.F. (Los Alamos National Lab., NM (USA))

    1990-01-01

    Selected topics are summarized from the Basic Experiments session of the Transport Task Force Workshop held August 21-24, 1989, in San Diego, California. This session included presentations on paradigm experiments, stellarators, reversed-field pinches, and advanced tokamaks. Recent advances in all of these areas illustrate the importance of these experiments in advancing our understanding of toroidal transport. Progress has been made in measuring the details of particle diffusion, isolating specific modes, measuring fluctuation variations with field geometry and beta, and comparing all these with theoretical predictions. The development of experimental tools for determining which fluctuations dominate transport are also reported. Continued significant advances are anticipated in a number of areas highlighted. (author).

  16. Transport Task Force workshop: basic experiments highlights

    International Nuclear Information System (INIS)

    Linford, R.K.; Luckhardt, S.; Lyon, J.F.; Navratil, G.A.; Schoenberg, K.F.

    1990-01-01

    Selected topics are summarized from the Basic Experiments session of the Transport Task Force Workshop held August 21-24, 1989, in San Diego, California. This session included presentations on paradigm experiments, stellarators, reversed-field pinches, and advanced tokamaks. Recent advances in all of these areas illustrate the importance of these experiments in advancing our understanding of toroidal transport. Progress has been made in measuring the details of particle diffusion, isolating specific modes, measuring fluctuation variations with field geometry and beta, and comparing all these with theoretical predictions. The development of experimental tools for determining which fluctuations dominate transport are also reported. Continued significant advances are anticipated in a number of areas highlighted. (author)

  17. Symmetric configurations highlighted by collective quantum coherence

    Energy Technology Data Exchange (ETDEWEB)

    Obster, Dennis [Radboud University, Institute for Mathematics, Astrophysics and Particle Physics, Nijmegen (Netherlands); Kyoto University, Yukawa Institute for Theoretical Physics, Kyoto (Japan); Sasakura, Naoki [Kyoto University, Yukawa Institute for Theoretical Physics, Kyoto (Japan)

    2017-11-15

    Recent developments in quantum gravity have shown the Lorentzian treatment to be a fruitful approach towards the emergence of macroscopic space-times. In this paper, we discuss another related aspect of the Lorentzian treatment: we argue that collective quantum coherence may provide a simple mechanism for highlighting symmetric configurations over generic non-symmetric ones. After presenting the general framework of the mechanism, we show the phenomenon in some concrete simple examples in the randomly connected tensor network, which is tightly related to a certain model of quantum gravity, i.e., the canonical tensor model. We find large peaks at configurations invariant under Lie-group symmetries as well as a preference for charge quantization, even in the Abelian case. In future study, this simple mechanism may provide a way to analyze the emergence of macroscopic space-times with global symmetries as well as various other symmetries existing in nature, which are usually postulated. (orig.)

  18. Physical Sciences 2007 Science & Technology Highlights

    Energy Technology Data Exchange (ETDEWEB)

    Hazi, A U

    2008-04-07

    The Physical Sciences Directorate applies frontier physics and technology to grand challenges in national security. Our highly integrated and multidisciplinary research program involves collaborations throughout Lawrence Livermore National Laboratory, the National Nuclear Security Administration, the Department of Energy, and with academic and industrial partners. The Directorate has a budget of approximately $150 million, and a staff of approximately 350 employees. Our scientists provide expertise in condensed matter and high-pressure physics, plasma physics, high-energy-density science, fusion energy science and technology, nuclear and particle physics, accelerator physics, radiation detection, optical science, biotechnology, and astrophysics. This document highlights the outstanding research and development activities in the Physical Sciences Directorate that made news in 2007. It also summarizes the awards and recognition received by members of the Directorate in 2007.

  19. Highlights from the 9th Cachexia Conference.

    Science.gov (United States)

    Ebner, Nicole; von Haehling, Stephan

    2017-06-01

    This article highlights updates of pathways as well as pre-clinical and clinical studies into the field of wasting disorders that were presented at the 9th Cachexia Conference held in Berlin, Germany, December 2016. This year, some interesting results from clinical trials and different new therapeutic targets were shown. This article presents the biological and clinical significance of different markers and new diagnostic tools and cut-offs of detecting skeletal muscle wasting. Effective treatments of cachexia and wasting disorders are urgently needed in order to improve the patients' quality of life and their survival. © 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders.

  20. Syndicate of renewable energies - Highlights 2016

    International Nuclear Information System (INIS)

    2017-01-01

    This publication first proposes a presentation of the SER (Syndicat des Energies Renouvelables, Syndicate of Renewable Energies), a professional body: missions, scope of action, members. It outlines its commitment in the French policy for energy transition as a major actor of the sector of renewable energies. It addresses the legal and regulatory framework as well as the economic framework and markets. It proposes brief presentations of transverse actions regarding power grids, overseas territories, the building sector and the international export. Some highlights related to ground-based wind power, renewable marine energies and offshore wind energy, solar photovoltaic energy, bio-energies (wood-fueled power plants for collective, tertiary and industrial sectors, biogas, biofuels and municipal wastes), domestic wood space heating, geothermal energy and hydroelectricity are mentioned. Actions in the field of communication are summarized, and projects for 2017 are briefly indicated

  1. ATOMLLL: atoms with shading and highlights

    International Nuclear Information System (INIS)

    Max, N.L.; y.

    1979-01-01

    The ATOMS program, written at Bell Telephone Laboratory, is capable of determining the visible portions of a scene consisting of interpenetrating spheres and cylinders, put together to represent space-filling or ball-and-stick molecular models. The Lawrence Livermore Laboratory version contains enhancements to add shading and highlights, and to render the spheres on film as ellipses, so they will appear round when projected in various wide-screen formats. The visible parts of each sphere or cylinder are shaded by a minicomputer controlling the film recorder, thus releasing the main computer from transferring the millions of intensity values for each frame. The minicomputer is microprogrammed with an efficient algorithm for the intensities, which uses the color look-up tables in the film recorder to store the reflectance as a function of angle of incidence. 8 references

  2. Research highlights: microfluidics meets big data.

    Science.gov (United States)

    Tseng, Peter; Weaver, Westbrook M; Masaeli, Mahdokht; Owsley, Keegan; Di Carlo, Dino

    2014-03-07

    In this issue we highlight a collection of recent work in which microfluidic parallelization and automation have been employed to address the increasing need for large amounts of quantitative data concerning cellular function--from correlating microRNA levels to protein expression, increasing the throughput and reducing the noise when studying protein dynamics in single-cells, and understanding how signal dynamics encodes information. The painstaking dissection of cellular pathways one protein at a time appears to be coming to an end, leading to more rapid discoveries which will inevitably translate to better cellular control--in producing useful gene products and treating disease at the individual cell level. From these studies it is also clear that development of large scale mutant or fusion libraries, automation of microscopy, image analysis, and data extraction will be key components as microfluidics contributes its strengths to aid systems biology moving forward.

  3. AGILE Data Center and AGILE science highlights

    International Nuclear Information System (INIS)

    Pittori, C.

    2013-01-01

    AGILE is a scientific mission of the Italian Space Agency (ASI) with INFN, INAF e CIFS participation, devoted to gamma-ray astrophysics. The satellite is in orbit since April 23rd, 2007. Gamma-ray astrophysics above 100 MeV is an exciting field of astronomical sciences that has received a strong impulse in recent years. Despite the small size and budget, AGILE produced several important scientific results, among which the unexpected discovery of strong and rapid gamma-ray flares from the Crab Nebula. This discovery won to the AGILE PI and the AGILE Team the prestigious Bruno Rossi Prize for 2012, an international recognition in the field of high energy astrophysics. We present here the AGILE data center main activities, and we give an overview of the AGILE scientific highlights after 5 years of operations

  4. 2006 highlights according to the IEA

    International Nuclear Information System (INIS)

    Lafon, M.

    2007-01-01

    The 2007 natural gas market review of the International energy agency (IEA) is this year subtitled: 'security in a globalizing market to 2015'. The review thus stresses on the 2006 highlights but reinforces the idea already expressed in the 2006 issue that energy security is now an inevitable topic. It offers also a prospective analysis of the natural gas market up to 2015 and devotes a full chapter to LNG development. As a matter of fact, the IEA considers that, from now to 2015, two thirds of the additional gas supplies will be in the form of LNG. The review supplies also some complements about some national markets. The present article reviews the most important points of this analysis. (J.S.)

  5. Physical Sciences 2007 Science and Technology Highlights

    International Nuclear Information System (INIS)

    Hazi, A.U.

    2008-01-01

    The Physical Sciences Directorate applies frontier physics and technology to grand challenges in national security. Our highly integrated and multidisciplinary research program involves collaborations throughout Lawrence Livermore National Laboratory, the National Nuclear Security Administration, the Department of Energy, and with academic and industrial partners. The Directorate has a budget of approximately $150 million, and a staff of approximately 350 employees. Our scientists provide expertise in condensed matter and high-pressure physics, plasma physics, high-energy-density science, fusion energy science and technology, nuclear and particle physics, accelerator physics, radiation detection, optical science, biotechnology, and astrophysics. This document highlights the outstanding research and development activities in the Physical Sciences Directorate that made news in 2007. It also summarizes the awards and recognition received by members of the Directorate in 2007

  6. Brookhaven highlights, October 1978-September 1979

    International Nuclear Information System (INIS)

    1979-01-01

    These highlights present an overview of the major research and development achievements at Brookhaven National Laboratory from October 1978 to September 1979. Specific areas covered include: accelerator and high energy physics programs; high energy physics research; the AGS and improvements to the AGS; neutral beam development; heavy ion fusion; superconducting power cables; ISABELLE storage rings; the BNL Tandem accelerator; heavy ion experiments at the Tandem; the High Flux Beam Reactor; medium energy physics; nuclear theory; atomic and applied physics; solid state physics; neutron scattering studies; x-ray scattering studies; solid state theory; defects and disorder in solids; surface physics; the National Synchrotron Light Source ; Chemistry Department; Biology Department; Medical Department; energy sciences; environmental sciences; energy technology programs; National Center for Analysis of Energy Systems; advanced reactor systems; nuclear safety; National Nuclear Data Center; nuclear materials safeguards; Applied Mathematics Department; and support activities

  7. Biotransformation and bioactivation reactions - 2016 literature highlights.

    Science.gov (United States)

    Khojasteh, S Cyrus; Rietjens, Ivonne M C M; Dalvie, Deepak; Miller, Grover

    2017-08-01

    We are pleased to present a second annual issue highlighting a previous year's literature on biotransformation and bioactivation. Each contributor to this issue worked independently to review the articles published in 2016 and proposed three to four articles, which he or she believed would be of interest to the broader research community. In each synopsis, the contributing author summarized the procedures, analyses and conclusions as described in the original manuscripts. In the commentary sections, our authors offer feedback and highlight aspects of the work that may not be apparent from an initial reading of the article. To be fair, one should still read the original article to gain a more complete understanding of the work conducted. Most of the articles included in this review were published in Drug Metabolism and Disposition or Chemical Research in Toxicology, but attempts were made to seek articles in 25 other journals. Importantly, these articles are not intended to represent a consensus of the best papers of the year, as we did not want to make any arbitrary standards for this purpose, but rather they were chosen by each author for their notable findings and descriptions of novel metabolic pathways or biotransformations. I am pleased that Drs. Rietjens and Dalvie have again contributed to this annual review. We would like to welcome Grover P Miller as an author for this year's issue, and we thank Tom Baillie for his contributions to last year's edition. We have intentionally maintained a balance of authors such that two come from an academic setting and two come from industry. Finally, please drop us a note if you find this review helpful. We would be pleased to hear your opinions of our commentary, and we extend an invitation to anyone who would like to contribute to a future edition of this review. This article is dedicated to Professor Thomas Baillie for his exceptional contributions to the field of drug metabolism.

  8. AGILE Highlights after Six Years in Orbit

    Directory of Open Access Journals (Sweden)

    Carlotta Pittori

    2014-12-01

    Full Text Available AGILE is an ASI space mission in collaboration with INAF, INFN and CIFS, dedicated to the observation of the gamma-ray Universe in the 30 MeV - 50 GeV energy range, with simultaneous X-ray imaging capability in the 18-60 keV band. The AGILE satellite was launched on April 23rd, 2007, and produced several important scientic results, among which the unexpected discovery of strong ares from the Crab Nebula. This discovery won to the AGILE PI and the AGILE Team the Bruno Rossi Prize for 2012 by the High Energy Astrophysics division of the American Astronomical Society. Thanks to its sky monitoring capability and fast ground segment alert system, AGILE detected many Galactic and extragalactic sources: among other results AGILE discovered gamma-ray emission from the microquasar Cygnus X-3, detected many bright blazars, discovered several new gamma-ray pulsars, and discovered emission up to 100 MeV from Terrestrial Gamma-Ray Flashes. We present an overview of the main AGILE Data Center activities and the AGILE scientic highlights after 6 years of operations.

  9. LHC Highlights, from dream to reality

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    The idea of the Large Hadron Collider (LHC) was born in the early 1980s. Although LEP (CERN’s previous large accelerator) was still under construction at that time, scientists were already starting to think about re-using the 27-kilometre ring for an even more powerful machine. Turning this ambitious scientific plan into reality proved to be an immensely complex task. Civil engineering work, state-of-the-art technologies, a new approach to data storage and analysis: many people worked hard for many years to accomplish all this.   Here are some of the highlights: 1984. A symposium organized in Lausanne, Switzerland, is the official starting point for the LHC. LHC prototype of the two beam pipes (1992). 1989. The first embryonic collaborations begin. 1992. A meeting in Evian, France, marks the beginning of the LHC experiments. 1994. The CERN Council approves the construction of the LHC accelerator. 1995. Japan becomes an Observer of CERN and announces a financial contribution to ...

  10. Argonne National Laboratory Research Highlights 1988

    International Nuclear Information System (INIS)

    Anon.

    1988-01-01

    The research and development highlights are summarized. The world's brightest source of X-rays could revolutionize materials research. Test of a prototype insertion device, a key in achieving brilliant X-ray beams, have given the first glimpse of the machine's power. Superconductivity research focuses on the new materials' structure, economics and applications. Other physical science programs advance knowledge of material structures and properties, nuclear physics, molecular structure, and the chemistry and structure of coal. New programming approaches make advanced computers more useful. Innovative approaches to fighting cancer are being developed. More experiments confirm the passive safety of Argonne's Integral Fast Reactor concept. Device simplifies nuclear-waste processing. Advanced fuel cell could provide better mileage, more power than internal combustion engine. New instruments find leaks in underground pipe, measure sodium impurities in molten liquids, detect flaws in ceramics. New antibody findings may explain ability to fight many diseases. Cadmium in cigarettes linked to bone loss in women. Programs fight deforestation in Nepal. New technology could reduce acid rain, mitigate greenhouse effect, enhance oil recovery. Innovative approaches transfer Argonne-developed technology to private industry. Each year Argonne educational programs reach some 1200 students

  11. Highlights from past and future physics

    CERN Multimedia

    Daisy Yuhas

    2009-01-01

    A two-day symposium was held at CERN on 3 and 4 December in celebration of the fiftieth anniversary of the Proton Synchrotron and the twentieth anniversary of LEP. The symposium, entitled “From the Proton Synchrotron to the Large Hadron Collider- 50 Years of Nobel Memories in High-Energy Physics”, included a series of seminars reflecting on the past fifty years in particle physics and an exhibition highlighting CERN’s research over this period.   Lyn Evans, LHC project leader, addressing the audience gathered in the Main Auditorium during the symposium that celebrated the 50 years of the PS and the 20 years of LEP.  The events were well attended on both days. Thursday’s reception, to which the Director-General invited everyone working at CERN, attracted over 1200 people. The seminars drew about 500 people to the Main Auditorium and the Council Chamber each day, with at least as many on-line attendees. The symposium speakers, including thirteen No...

  12. Highlights on the IAEA project QUATRO

    International Nuclear Information System (INIS)

    Milano, F.

    2012-01-01

    The success of radiotherapy in term of prob- ability of local control of the tumor and the limiting factor in treatments in term of probability of complications are strictly depending on the accuracy and precision of the pa- tient treatment. An overall Quality Assurance programme (QAP) has been recognized as an essential tool to assure that the goals of radiotherapy are achieved. As part of a comprehensive approach to QAP an independent external audit is considered a very effective method of checking that the quality of activities in an Institution permits to achieve the required objectives. Since many years the International Atomic Energy Agency (IAEA) has audited Member States for radiotherapy dosimetry, for educating and training radio- therapy professionals and for reviewing the radiotherapy process. Recently a new approach has been developed and named ''Quality Assurance Team for Radiation Oncology (QUATRO)''. The principal aim of QUATRO is to review all the radiotherapy process, including organization, infra- structure, clinical and medical physics aspects of the radio- therapy services. It also includes a review of the hospital's professional competence with a view to quality improve- ment. The aim of this paper is to introduce and to highlight the QUATRO methodology describing its effectiveness on improving either the quality of the radiotherapy treatments and in general the management of the patient.

  13. Engineering sciences research highlights. Fiscal year 1983

    International Nuclear Information System (INIS)

    Tucker, E.F.; Dobratz, B.

    1984-05-01

    The Laboratory's overall mission is sixfold. We are charged with developing nuclear warheads for defense, technology for arms control, and new concepts for defense against nuclear attack; with supporting programs for both nonnuclear defense and energy research and development; and with advancing our knowledge of science and technology so that we can respond to other national needs. Major programs in support of this mission involve nuclear weapons, energy, environmental science, and basic research. Specific areas of investigation include the design, development, and testing of nuclear weapons; nuclear safeguards and security; inertial and magnetic fusion and nuclear, solar, fossil, and geothermal energy; and basic research in physics, chemistry, mathematics, engineering, and the computer and life sciences. With the staff and facilities maintained for these and other programs, the Laboratory can respond to specific national needs in virtually all areas of the physical and life sciences. Within the Laboratory's organization, most technical research activities are carried out in three directorates: Engineering Sciences; Physics and Mathematics; and Chemistry, Earth and Life Sciences. The activities highlighted here are examples of unclassified work carried out in the seven divisions that made up the Engineering Sciences Directorate at the end of fiscal year 1983. Brief descriptions of these divisions' goals and capabilities and summaries of selected projects illustrate the diversity of talent, expertise, and facilities maintained within the Engineering Sciences Directorate

  14. Palm-based diacylglycerol fat dry fractionation: effect of crystallisation temperature, cooling rate and agitation speed on physical and chemical properties of fractions

    Directory of Open Access Journals (Sweden)

    Razam Ab Latip

    2013-05-01

    Full Text Available Fractionation which separates the olein (liquid and stearin (solid fractions of oil is used to modify the physicochemical properties of fats in order to extend its applications. Studies showed that the properties of fractionated end products can be affected by fractionation processing conditions. In the present study, dry fractionation of palm-based diacylglycerol (PDAG was performed at different: cooling rates (0.05, 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0°C/min, end-crystallisation temperatures (30, 35, 40, 45 and 50°C and agitation speeds (30, 50, 70, 90 and 110 rpm to determine the effect of these parameters on the properties and yield of the solid and liquid portions. To determine the physicochemical properties of olein and stearin fraction: Iodine value (IV, fatty acid composition (FAC, acylglycerol composition, slip melting point (SMP, solid fat content (SFC, thermal behaviour tests were carried out. Fractionation of PDAG fat changes the chemical composition of liquid and solid fractions. In terms of FAC, the major fatty acid in olein and stearin fractions were oleic (C18:1 and palmitic (C16:0 respectively. Acylglycerol composition showed that olein and stearin fractions is concentrated with TAG and DAG respectively. Crystallization temperature, cooling rate and agitation speed does not affect the IV, SFC, melting and cooling properties of the stearin fraction. The stearin fraction was only affected by cooling rate which changes its SMP. On the other hand, olein fraction was affected by crystallization temperature and cooling rate but not agitation speed which caused changes in IV, SMP, SFC, melting and crystallization behavior. Increase in both the crystallization temperature and cooling rate caused a reduction of IV, increment of the SFC, SMP, melting and crystallization behaviour of olein fraction and vice versa. The fractionated stearin part melted above 65°C while the olein melted at 40°C. SMP in olein fraction also reduced to a range of

  15. Highlights from Johannesburg, Gauteng Province, South Africa

    Science.gov (United States)

    2002-01-01

    Although the extraction of mineral wealth has been the major influence in the history of Johannesburg and the surrounding Witwatersrand regions (with about 45% of all gold ever mined coming from there), the discovery of now-famous hominid fossils at the Sterkfontein Caves, and the convening of the world's largest-ever conference on environment and development, are setting a new stage for the future. The United Nations began the second Development and Environment Conference in Johannesburg on August 26, 2002. This meeting addresses the implementation of international goals to fight poverty and protect the global environment that were established at the first such conference held in Rio de Janeiro in 1992. The Johannesburg summit involves about forty thousand participants, and perhaps 100 world leaders. One of several official opening ceremonies for the conference was held at the Sterkfontein Caves to recognize the outstanding universal value of the paleo-anthropological fossils found there.These views from the Multi-angle Imaging SpectroRadiometer (MISR) highlight a number of the land use, vegetation, and geological features found within Gauteng Province (including the urban center of Johannesburg and the capital city Pretoria) and parts of the North West and Free State Provinces. The image on the right displays vegetation in red hues and is a false-color view utilizing data from MISR's near-infrared, red and blue bands. Both the natural-color view (left) and the false-color version were acquired by MISR's nadir camera on June 16, 2002. The urban areas appear as gray-colored pixels in the natural-color view, and exhibit colors corresponding with the relative abundance of vegetation found in the urban parts of this arid region.The mountains trending east-west near the center of the images extend from Pretoria in the east to Rustenberg in the west. These ranges, the Magaliesberg and Witwatersberg, separate the low-lying, hotter bushveld to the north from the cooler

  16. Electric transport in the Netherlands. Highlights 2012; Elektrisch vervoer in Nederland. Highlights 2012

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-03-15

    Businesses, social and educational institutions and governmental institutes work together to accelerate electric transport and to discover and exploit economic opportunities. In 2012, many activities were carried out and results achieved, of which the highlights are presented in this brochure [Dutch] Bedrijfsleven, maatschappelijke- en kennisinstellingen en overheden werken samen aan versnelling van elektrisch vervoer en het ontdekken en benutten van economische kansen. In 2012 werden veel activiteiten uitgevoerd en resultaten geboekt, waarvan in deze brochure verslag wordt gedaan.

  17. Towards a Moon Village : Community Workshops Highlights

    Science.gov (United States)

    Foing, Bernard H.

    2016-07-01

    . References: [1] http://sci.esa.int/ilewg/ and https://ildwg.wordpress.com/ [2] Foing B. Moon exploration highlights and Moon Village introduction. [3] Young Lunar Explorers Report ESTEC Moon village sessions with community and young professionals.

  18. Crystallisation kinetics of amorphous Fe{sub 72.5-x}Cu{sub 1}Nb{sub 4.5}Si{sub 10+x+y}B{sub 12-y} alloy

    Energy Technology Data Exchange (ETDEWEB)

    Miglierini, M. [Komenskeho Univ., Bratislava (Czechoslovakia). Dept. of Nuclear Physics and Technics; Lipka, J. [Komenskeho Univ., Bratislava (Czechoslovakia). Dept. of Nuclear Physics and Technics; Sitek, J. [Komenskeho Univ., Bratislava (Czechoslovakia). Dept. of Nuclear Physics and Technics

    1994-11-01

    Fe{sub 73.5}Cu{sub 1}Nb{sub 3}Si{sub 13.5}B{sub 9} and Fe{sub 72.5-x}Cu{sub 1}Nb{sub 4.5}Si{sub 10+x+y}B{sub 12-y} alloys are compared from the point of view of crystallisation behaviour and changes in the short-range order in the amorphous reminder. The increase in Nb to 4.5 at.% in the latter system slows down the formation of nanocrystals to approximately 40% even after 16 hours of anneal at 550 C for x = 0.5, y = 3. Segregation-induced changes in the short-range order are manifested via hyperfine field distributions corresponding to the amorphous reminder. (orig.)

  19. Difference between highlight and object colors enhances glossiness.

    Science.gov (United States)

    Hanada, Mitsuhiko

    2012-06-01

    The effect of highlight and object colors on perception of glossiness was examined. Ten participants rated glossiness of object images. The color coordinates of objects and highlights were varied while luminance of each pixel was unchanged. Four colors were used for objects and highlights. Objects were perceived as glossier when the highlight color was different from the object color than when they were the same. Objects with some unnatural combinations of highlight and object colors were perceived to be as glossy as those with natural color combinations. The results suggested that differences between highlight and object colors enhance perceived glossiness and that perceived glossiness does not depend on naturalness of color combination for highlights and objects.

  20. Brookhaven highlights, October 1, 1989--September 30, 1990

    Energy Technology Data Exchange (ETDEWEB)

    Rowe, M.S.; Cohen, A.; Greenberg, D.; Seubert, L.; Kuper, J.B.H. (eds.)

    1990-01-01

    This report discusses research being conducted at Brookhaven National Laboratory. Highlights from all the department are illustrated. The main topics are on accelerator development and applications. (LSP)

  1. Automatic Online Lecture Highlighting Based on Multimedia Analysis

    Science.gov (United States)

    Che, Xiaoyin; Yang, Haojin; Meinel, Christoph

    2018-01-01

    Textbook highlighting is widely considered to be beneficial for students. In this paper, we propose a comprehensive solution to highlight the online lecture videos in both sentence- and segment-level, just as is done with paper books. The solution is based on automatic analysis of multimedia lecture materials, such as speeches, transcripts, and…

  2. Small Drinking Water Systems Communication and Outreach Highlights

    Science.gov (United States)

    As part of our small drinking water systems efforts, this poster highlights several communications and outreach highlights that EPA's Office of Research and Development and Office of Water have been undertaking in collaboration with states and the Association of State Drinking Wa...

  3. Is Domain Highlighting Actually Helpful in Identifying Phishing Web Pages?

    Science.gov (United States)

    Xiong, Aiping; Proctor, Robert W; Yang, Weining; Li, Ninghui

    2017-06-01

    To evaluate the effectiveness of domain highlighting in helping users identify whether Web pages are legitimate or spurious. As a component of the URL, a domain name can be overlooked. Consequently, browsers highlight the domain name to help users identify which Web site they are visiting. Nevertheless, few studies have assessed the effectiveness of domain highlighting, and the only formal study confounded highlighting with instructions to look at the address bar. We conducted two phishing detection experiments. Experiment 1 was run online: Participants judged the legitimacy of Web pages in two phases. In Phase 1, participants were to judge the legitimacy based on any information on the Web page, whereas in Phase 2, they were to focus on the address bar. Whether the domain was highlighted was also varied. Experiment 2 was conducted similarly but with participants in a laboratory setting, which allowed tracking of fixations. Participants differentiated the legitimate and fraudulent Web pages better than chance. There was some benefit of attending to the address bar, but domain highlighting did not provide effective protection against phishing attacks. Analysis of eye-gaze fixation measures was in agreement with the task performance, but heat-map results revealed that participants' visual attention was attracted by the highlighted domains. Failure to detect many fraudulent Web pages even when the domain was highlighted implies that users lacked knowledge of Web page security cues or how to use those cues. Potential applications include development of phishing prevention training incorporating domain highlighting with other methods to help users identify phishing Web pages.

  4. Highlighting material structure with transmission electron diffraction correlation coefficient maps

    International Nuclear Information System (INIS)

    Kiss, Ákos K.; Rauch, Edgar F.; Lábár, János L.

    2016-01-01

    Correlation coefficient maps are constructed by computing the differences between neighboring diffraction patterns collected in a transmission electron microscope in scanning mode. The maps are shown to highlight material structural features like grain boundaries, second phase particles or dislocations. The inclination of the inner crystal interfaces are directly deduced from the resulting contrast. - Highlights: • We propose a novel technique to image the structure of polycrystalline TEM-samples. • Correlation coefficients maps highlights the evolution of the diffracting signal. • 3D views of grain boundaries are provided for nano-particles or polycrystals.

  5. Corelation between the crystallisation process and change in thermoelectromotive force for the amorphous alloy Fe89.8Ni1.5Si5.2B3C0.5

    Directory of Open Access Journals (Sweden)

    Maričić Aleksa M.

    2003-01-01

    Full Text Available Thermal and kinetic analyses of the structural changes for the amorphous alloy Fe89.8Ni1.5Si5.2B3C0.5, during the processes of non-isothermal heating and isothermal annealing, have been performed. The crystallisation process has been investigated using the method of differential scanning calorimetry (DSC. It is determined that this alloy crystalizes through three different stages. Changes in the electronic structure of the amorphous tape, for the temperature range 20 to 700ºC have been studied. This was achieved by measuring the thermoelectromotive force (TEMS, of the thermo pair made of two tapes with same chemical structure of the alloy FeNiSiBC, but different atomic structure: one is in the crystal state (CL and the other is in the amorphous state (AM. Analysis of the temperature dependence of the electromotive force has shown the following: the investigated alloy is thermically stable up to 450ºC and changes in the atomic structure as well as equalising of the free electron density in both parts of the thermo pair AM-CL, take place in the temperature range from 450 to 550ºC. Kinetic parameters of the process were determined by measuring time dependence of the TEMS in isothermic conditions at the temperatures 450, 480 and 510ºC.

  6. Special journal issue highlights IDRC-supported findings on ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2018-03-08

    Mar 8, 2018 ... Special journal issue highlights IDRC-supported findings on women's paid work ... An important aspect of women's economic empowerment is their participation in the labour ... Maternal health research concerns men too.

  7. EMSL Quarterly Highlights Report: FY 2008, 3rd Quarter

    Energy Technology Data Exchange (ETDEWEB)

    Showalter, Mary Ann

    2008-09-16

    The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2007 - December 2007) of Fiscal Year 2008.

  8. EMSL Quarterly Highlights Report: 1st Quarter, FY08

    Energy Technology Data Exchange (ETDEWEB)

    Showalter, Mary Ann

    2008-01-28

    The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2007 - December 2007) of Fiscal Year 2008.

  9. Highlight: IDRC at the World Congress on Public Health 2015 ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-04-14

    Apr 14, 2016 ... ... and communication tools such as radio jingles and internet messages. ... They highlighted best practices in Thailand, which has an effective ... for Health Sciences, Kunming Medical University, Yunnan Province, China.

  10. 2016 Highlights of Ferry Operations in the United States

    Science.gov (United States)

    2017-10-01

    This publication highlights data collected by the 2016 NCFO. The Bureau of Transportation Statistics (BTS) conducted the NCFO from April through November 2016, collecting the operational characteristics of the 2015 calendar year ferry operations.

  11. FY17 Transportation and Hydrogen Systems Center Journal Publication Highlights

    Energy Technology Data Exchange (ETDEWEB)

    2017-12-08

    NREL's Transportation and Hydrogen Systems Center published 39 journal articles in fiscal year 2017 highlighting recent research in advanced vehicle technology, alternative fuels, and hydrogen systems.

  12. Highlight: Youth (Un)Employment: Global problems meet local ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-07-07

    Jul 7, 2016 ... ... because there is a huge knowledge gap between what we consider formal ... economic development programming, especially for women and youth. ... Highlight: Ankara workshop puts minimum wage on the G-20 radar.

  13. EMSL Quarterly Highlights Report: 1st Quarter, Fiscal Year 2009

    Energy Technology Data Exchange (ETDEWEB)

    Showalter, Mary Ann; Kathmann, Loel E.; Manke, Kristin L.

    2009-02-02

    The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2008 - December 2008) of Fiscal Year 2009.

  14. Physical and Life Sciences 2008 Science & Technology Highlights

    Energy Technology Data Exchange (ETDEWEB)

    Correll, D L; Hazi, A U

    2009-05-06

    This document highlights the outstanding research and development activities in the Physical and Life Sciences Directorate that made news in 2008. It also summarizes the awards and recognition received by members of the Directorate in 2008.

  15. Highlights in emergency medicine medical education research: 2008.

    Science.gov (United States)

    Farrell, Susan E; Coates, Wendy C; Khun, Gloria J; Fisher, Jonathan; Shayne, Philip; Lin, Michelle

    2009-12-01

    The purpose of this article is to highlight medical education research studies published in 2008 that were methodologically superior and whose outcomes were pertinent to teaching and education in emergency medicine. Through a PubMed search of the English language literature in 2008, 30 medical education research studies were independently identified as hypothesis-testing investigations and measurements of educational interventions. Six reviewers independently rated and scored all articles based on eight anchors, four of which related to methodologic criteria. Articles were ranked according to their total rating score. A ranking agreement among the reviewers of 83% was established a priori as a minimum for highlighting articles in this review. Five medical education research studies met the a priori criteria for inclusion and are reviewed and summarized here. Four of these employed experimental or quasi-experimental methodology. Although technology was not a component of the structured literature search employed to identify the candidate articles for this review, 14 of the articles identified, including four of the five highlighted articles, employed or studied technology as a focus of the educational research. Overall, 36% of the reviewed studies were supported by funding; three of the highlighted articles were funded studies. This review highlights quality medical education research studies published in 2008, with outcomes of relevance to teaching and education in emergency medicine. It focuses on research methodology, notes current trends in the use of technology for learning in emergency medicine, and suggests future avenues for continued rigorous study in education.

  16. A solvent induced crystallisation method to imbue bioactive ingredients of neem oil into the compact structure of poly (ethylene terephthalate) polyester

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Wazed [Department of Textile Technology, Indian Institute of Technology, Hauz Khas, New Delhi 110016 (India); Sultana, Parveen [Department of Physics, Jadavpur University, Kolkata 700032 (India); Joshi, Mangala [Department of Textile Technology, Indian Institute of Technology, Hauz Khas, New Delhi 110016 (India); Rajendran, Subbiyan, E-mail: sr2@bolton.ac.uk [Institute for Materials Research and Innovation, The University of Bolton, Bolton BL3 5AB (United Kingdom)

    2016-07-01

    Neem oil, a natural antibacterial agent from neem tree (Azadarichtaindica) has been used to impart antibacterial activity to polyester fabrics. Solvent induced polymer modification method was used and that facilitated the easy entry of neem molecules into the compact structure of polyethylene terephthalate (PET) polyester. The polyester fabric was treated with trichloroacetic acid-methylene chloride (TCAMC) solvent system at room temperature prior to treatment with neem oil. The concentration of TCAMC and the treatment time were optimised. XRD and SEM results showed that the TCAMC treatment causes polymer modification and morphological changes in the PET polyester. Antibacterial activity of TCAMC pre-treated and neem-oil-treated polyester fabric was tested using AATCC qualitative and quantitative methods. Both Gram-positive and Gram-negative organisms were used to determine the antimicrobial activity. It was observed that the treated fabric registers substantial antimicrobial activity against both the Staphylococcus aureus (Gram-positive) and the Escherichia coli (Gram-negative) and the effect increases with the increase in concentration of TCAMC treatment. The antibacterial effect remains substantial even after 25 launderings. A kinetic growth study involving the effect of antibacterial activity at various incubation times was carried out. - Highlights: • A novel technique whereby the antibacterial components of neem oil are imbued into the compact structure of PET polyester • Trichloroacetic acid-Methylene Chloride treatment facilitated the easy entry of neem ingredients into the PET structure • Neem oil treated PET registered substantial antibacterial efficacy • Antibacterial effect is retained even after multiple use-wash cycles.

  17. Mental Health Disorders. Adolescent Health Highlight. Publication #2013-1

    Science.gov (United States)

    Murphey, David; Barry, Megan; Vaughn, Brigitte

    2013-01-01

    Mental disorders are diagnosable conditions characterized by changes in thinking, mood, or behavior (or some combination of these) that can cause a person to feel stressed out and impair his or her ability to function. These disorders are common in adolescence. This "Adolescent Health Highlight" presents the warning signs of mental disorders;…

  18. HIV and Cancer Interaction Highlights Need to Address Disease Stigma

    Science.gov (United States)

    The global landscape of disease highlights disparities that exist between nations. An estimated 36 million people worldwide live with HIV and AIDS, of which only 1 million are located within the United States. While the diagnosis of a life-threatening disease can be devastating, individuals with HIV and AIDS frequently bear an additional burden of stigma and discrimination.

  19. Highlights from the 7th European Meeting on Molecular Diagnostics

    NARCIS (Netherlands)

    Dr. A.J.C. van den Brule, van den; Drs A.J.M. Loonen; Dr. R. Schuurman

    2012-01-01

    This report presents the highlights of the 7th European Meeting on Molecular Diagnostics held in Scheveningen, The Hague, The Netherlands, 12-14 October 2011. The areas covered included molecular diagnostics applications in medical microbiology, virology, pathology, hemato-oncology,clinical genetics

  20. Fabricating graphene supercapacitors: highlighting the impact of surfactants and moieties.

    Science.gov (United States)

    Brownson, Dale A C; Banks, Craig E

    2012-02-01

    We highlight the impact of surfactants, routinely used in the fabrication of graphene, which can significantly influence the performance of supercapacitors. Through the utilisation of various graphitic forms we offer insight into the design and fabrication of graphene based supercapacitors. This journal is © The Royal Society of Chemistry 2012

  1. NCI intramural research highlighted at 2014 AACR meeting

    Science.gov (United States)

    This year’s American Association for Cancer Research meeting featured plenary talks by two NCI scientists, Steven Rosenberg, M.D., and Louis Staudt, M.D., Ph.D., that highlighted the challenges in developing varied and potentially synergistic treatments f

  2. Spring Research Festival Highlighted on WHAG-TV | Poster

    Science.gov (United States)

    WHAG-TV (Hagerstown, Md.) visited Fort Detrick to highlight the 2015 Spring Research Festival (SRF), sponsored by the National Interagency Confederation for Biological Research (NICBR). Visit the WHAG-TV website to see the video broadcast, which aired May 6. The video was produced by WHAG Reporter Mallory Sofastaii. The video featured Linganore High School senior Rebecca

  3. Tobacco Use. Adolescent Health Highlight. Publication #2012-33

    Science.gov (United States)

    Murphey, David; Barry, Megan; Vaughn, Brigitte; Terzian, Mary

    2012-01-01

    Cigarette smoking has steadily declined among adolescents during the last fifteen years, although use of some tobacco products, like cigars, has seen recent increases. However, large numbers of teens continue to use tobacco products. This "Adolescent Health Highlight" presents key research findings; describes prevalence and trends; illustrates…

  4. Highlights of the 8th International Veterinary Immunology Symposium

    Science.gov (United States)

    Veterinary immunologists have expanded understanding of the immune systems for our companion animals and developed new vaccines and therapeutics. This manuscript summarizes the highlights of the 8th International Veterinary Immunology Symposium (8 th IVIS) held August 15th-19th, 2007, in Ouro Preto,...

  5. The Shortcomings of Medical Education Highlighted through Film

    Science.gov (United States)

    Mahajan, Pranav

    2012-01-01

    The aims of this report are to highlight the shortcomings in medical education. To use a student made short film as an example of how issues that cause medical student distress can be displayed. To show that the process of film-making is a useful tool in reflection. To display that film is an effective device in raising awareness. (Contains 3…

  6. Geothermal Today: 2003 Geothermal Technologies Program Highlights (Revised)

    Energy Technology Data Exchange (ETDEWEB)

    2004-05-01

    This outreach publication highlights milestones and accomplishments of the DOE Geothermal Technologies Program for 2003. Included in this publication are discussions of geothermal fundamentals, enhanced geothermal systems, direct-use applications, geothermal potential in Idaho, coating technology, energy conversion R&D, and the GeoPowering the West initiative.

  7. Highlights from the ATLAS experiment at CERN LHC

    CERN Document Server

    Tsukerman, Ilya; The ATLAS collaboration

    2018-01-01

    Highlights from the ATLAS Experiment at the LHC are presented. Results shown are mostly based on the analysis of 2015-2016 year dataset which corresponds to the luminosity 36 inverse fb. Mainly recent measurements of Higgs boson production and decay are discussed while only summary of summaries is given for the SM processes, top production, SUSY and Exotics.

  8. Medicaid Highlights: Mental-Behavioral Health Data: 2001 NHIS

    OpenAIRE

    Lied, Terry R.

    2004-01-01

    These data highlights are based on analysis of the 2001 National Health Interview Survey (NHIS) public use data (http://www.cdc.gov/nchs/nhis.htm). NHIS is a multi-purpose survey conducted by the National Center for Health Statistics, Centers for Disease Control and Prevention. NHIS has been conducted continuously since 1957.

  9. Highlighting material structure with transmission electron diffraction correlation coefficient maps.

    Science.gov (United States)

    Kiss, Ákos K; Rauch, Edgar F; Lábár, János L

    2016-04-01

    Correlation coefficient maps are constructed by computing the differences between neighboring diffraction patterns collected in a transmission electron microscope in scanning mode. The maps are shown to highlight material structural features like grain boundaries, second phase particles or dislocations. The inclination of the inner crystal interfaces are directly deduced from the resulting contrast. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Highlights of the new U.S. Energy Policy Plan

    International Nuclear Information System (INIS)

    Rusche, B.C.

    1982-01-01

    This paper gives the highlights of the New U.S. Energy Policy Plan, a reformulation of policies affecting energy, as part of President Reagan's comprehensive Program for Economic Recovery. A survey is given of the different energy sources and their importances now and in the future along with a definition of the government's and the private sector's roles in energy production. (orig.)

  11. Advanced Education and Technology Business Plan, 2009-12. Highlights

    Science.gov (United States)

    Alberta Advanced Education and Technology, 2009

    2009-01-01

    Advanced Education and Technology provides strategic leadership for the development of the next generation economy in Alberta through the provision of accessible, affordable and quality learning opportunities for all Albertans and support for a dynamic and integrated innovation system. This paper provides the highlights of the business plan of the…

  12. Advanced Education and Technology Business Plan, 2010-13. Highlights

    Science.gov (United States)

    Alberta Advanced Education and Technology, 2010

    2010-01-01

    The Ministry of Advanced Education and Technology envisions Alberta's prosperity through innovation and lifelong learning. Advanced Education and Technology's mission is to lead the development of a knowledge-driven future through a dynamic and integrated advanced learning and innovation system. This paper presents the highlights of the business…

  13. Luminescence spectroscopy with synchrotron radiation: History, highlights, future

    International Nuclear Information System (INIS)

    Zimmerer, Georg

    2006-01-01

    Luminescence spectroscopy and the investigation of dynamical processes with synchrotron radiation (SR) started about 35 years ago in nearly all SR laboratories existing at that time. In the present paper, the pioneering experiments are particularly emphasized. The exciting development is illustrated presenting highlights for the whole period from the beginning to the present day. The highlights are taken from fields like exciton self-trapping, inelastic electron-electron scattering, optically stimulated desorption, cross luminescence, or probing of cluster properties with luminescence spectroscopic methods. More technological aspects play a role in present day's experiments, like quantum cutting in rare-earth-doped insulators. Promising two-photon excitation and light amplification experiments with SR will be included, as well as the first results obtained in a luminescence experiment with selective Vaccum ultraviolet-free electron laser excitation. Finally, a few ideas concerning the future development of luminescence spectroscopy with SR will be sketched

  14. Using Publication Metrics to Highlight Academic Productivity and Research Impact

    Science.gov (United States)

    Carpenter, Christopher R.; Cone, David C.; Sarli, Cathy C.

    2016-01-01

    This article provides a broad overview of widely available measures of academic productivity and impact using publication data and highlights uses of these metrics for various purposes. Metrics based on publication data include measures such as number of publications, number of citations, the journal impact factor score, and the h-index, as well as emerging metrics based on document-level metrics. Publication metrics can be used for a variety of purposes for tenure and promotion, grant applications and renewal reports, benchmarking, recruiting efforts, and administrative purposes for departmental or university performance reports. The authors also highlight practical applications of measuring and reporting academic productivity and impact to emphasize and promote individual investigators, grant applications, or department output. PMID:25308141

  15. Highlights of articles published in annals of nuclear medicine 2016

    International Nuclear Information System (INIS)

    Jadvar, Hossein

    2017-01-01

    This article is the first installment of highlights of selected articles published during 2016 in the Annals of Nuclear Medicine, an official peer-reviewed journal of the Japanese Society of Nuclear Medicine. A companion article highlighting selected articles published during 2016 in the European Journal of Nuclear Medicine and Molecular Imaging, which is the official peer-reviewed journal of the European Association of Nuclear Medicine, will also appear in the Annals Nuclear Medicine. This new initiative by the respective journals will continue as an annual endeavor and is anticipated to not only enhance the scientific collaboration between Europe and Japan but also facilitate global partnership in the field of nuclear medicine and molecular imaging. (orig.)

  16. Highlights of articles published in annals of nuclear medicine 2016

    Energy Technology Data Exchange (ETDEWEB)

    Jadvar, Hossein [University of Southern California, Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine, Los Angeles, CA (United States)

    2017-10-15

    This article is the first installment of highlights of selected articles published during 2016 in the Annals of Nuclear Medicine, an official peer-reviewed journal of the Japanese Society of Nuclear Medicine. A companion article highlighting selected articles published during 2016 in the European Journal of Nuclear Medicine and Molecular Imaging, which is the official peer-reviewed journal of the European Association of Nuclear Medicine, will also appear in the Annals Nuclear Medicine. This new initiative by the respective journals will continue as an annual endeavor and is anticipated to not only enhance the scientific collaboration between Europe and Japan but also facilitate global partnership in the field of nuclear medicine and molecular imaging. (orig.)

  17. OSART mission highlights related to on-the-job training

    International Nuclear Information System (INIS)

    Mazour, T.; Hide, K.

    1996-01-01

    This paper summarizes the highlights, related to the topic of on-the-job training (OJT), for Agency OSART missions conducted since 1990 (a total of 27 missions). Recommendations and suggestions for improvements related to on-the-job training and qualification programmes are discussed, as well as Good Practices and Good Performances. For Good Practices and Good Performances, the plant is identified to aid in follow-up by meeting participants. For recommendations and suggestions, the number of plants that had recommendations/findings in this area are identified by a number in parentheses after the item. The paper takes a broad approach toward highlights that are related to OJT. For example, there have been a number of OSART recommendations and suggestions concerning responsibilities, authorities and interfaces for NPP activities. These recommendations and suggestions relate not only to responsibilities and interfaces for on-the-job training and qualification programmes, but also to other areas as well

  18. Highlighted requests of neutron nuclear data measurements for fission reactors

    International Nuclear Information System (INIS)

    1977-01-01

    Highlighted requests were selected from lists of requests for neutron nuclear Data measurements. This work was made by WRENDA Working Group of Japanese Nuclear Data Committee in response to an action of the NEANDC. This will be submitted to a NEA meeting on request lists. Compiled requests in this note correspond finally to the parts of the WRENDA 76/77 with some modifications and additional comments. (auth.)

  19. NRC safety research in support of regulation. Selected highlights

    International Nuclear Information System (INIS)

    1986-05-01

    The report presents selected highlights of how research has contributed to the regulatory effort. It explains the research role of the NRC and nuclear safety research contributions in the areas of: pressure vessel integrity, piping, small- and large-break loss-of-coolant accidents, hydrogen and containment, source term analysis, seismic hazards and high-level waste management. The report also provides a summary of current and future research directions in support of regulation

  20. New highlights on stroma–epithelial interactions in breast cancer

    International Nuclear Information System (INIS)

    Barcellos-Hoff, Mary Helen; Medina, Daniel

    2005-01-01

    Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches

  1. Tourette syndrome research highlights 2015 [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Cheryl A. Richards

    2016-06-01

    Full Text Available We present selected highlights from research that appeared during 2015 on Tourette syndrome and other tic disorders. Topics include phenomenology, comorbidities, developmental course, genetics, animal models, neuroimaging, electrophysiology, pharmacology, and treatment. We briefly summarize articles whose results we believe may lead to new treatments, additional research or modifications in current models of TS.

  2. Nuclear fuel waste management - biosphere program highlights - 1978 to 1996

    Energy Technology Data Exchange (ETDEWEB)

    Zach, R

    1997-07-01

    The biosphere program in support of the development of the disposal concept for Canadian nuclear fuel waste since 1978 is scheduled for close-out. AECL`s Environmental Science Branch (ESB) was mainly responsible for work in this program. In order to preserve as much information as possible, this report highlights many of the key achievements of the program, particularly those related to the development of the BIOTRAC biosphere model and its supporting research. This model was used for the assessment and review of the disposal concept in an environmental impact statement (EIS). The report also treats highlights related to alternative models, external scientific/technical reviews, EIS feedback, and the international BIOMOVS model validation program. Furthermore, it highlights basic aspects of future modelling and research needs in relation to siting a disposal facility. In this, feedback from the various reviews and the EIS is taken into account. Appendices of the report include listings of key ESB staff involved in the program, all the scientific/technical reports and papers produced under the program, contracts let to outside agencies, and issues raised by various participants or intervenors during the EIS review. Although the report is concerned with close-out of the biosphere program, it also provides valuable information for a continuing program concerned with siting a disposal facility. One of the conclusions of the report is that such a program is essential for successfully siting such a facility. (author) Refs.

  3. Nuclear fuel waste management - biosphere program highlights - 1978 to 1996

    International Nuclear Information System (INIS)

    Zach, R.

    1997-07-01

    The biosphere program in support of the development of the disposal concept for Canadian nuclear fuel waste since 1978 is scheduled for close-out. AECL's Environmental Science Branch (ESB) was mainly responsible for work in this program. In order to preserve as much information as possible, this report highlights many of the key achievements of the program, particularly those related to the development of the BIOTRAC biosphere model and its supporting research. This model was used for the assessment and review of the disposal concept in an environmental impact statement (EIS). The report also treats highlights related to alternative models, external scientific/technical reviews, EIS feedback, and the international BIOMOVS model validation program. Furthermore, it highlights basic aspects of future modelling and research needs in relation to siting a disposal facility. In this, feedback from the various reviews and the EIS is taken into account. Appendices of the report include listings of key ESB staff involved in the program, all the scientific/technical reports and papers produced under the program, contracts let to outside agencies, and issues raised by various participants or intervenors during the EIS review. Although the report is concerned with close-out of the biosphere program, it also provides valuable information for a continuing program concerned with siting a disposal facility. One of the conclusions of the report is that such a program is essential for successfully siting such a facility. (author)

  4. Ranking Highlights in Personal Videos by Analyzing Edited Videos.

    Science.gov (United States)

    Sun, Min; Farhadi, Ali; Chen, Tseng-Hung; Seitz, Steve

    2016-11-01

    We present a fully automatic system for ranking domain-specific highlights in unconstrained personal videos by analyzing online edited videos. A novel latent linear ranking model is proposed to handle noisy training data harvested online. Specifically, given a targeted domain such as "surfing," our system mines the YouTube database to find pairs of raw and their corresponding edited videos. Leveraging the assumption that an edited video is more likely to contain highlights than the trimmed parts of the raw video, we obtain pair-wise ranking constraints to train our model. The learning task is challenging due to the amount of noise and variation in the mined data. Hence, a latent loss function is incorporated to mitigate the issues caused by the noise. We efficiently learn the latent model on a large number of videos (about 870 min in total) using a novel EM-like procedure. Our latent ranking model outperforms its classification counterpart and is fairly competitive compared with a fully supervised ranking system that requires labels from Amazon Mechanical Turk. We further show that a state-of-the-art audio feature mel-frequency cepstral coefficients is inferior to a state-of-the-art visual feature. By combining both audio-visual features, we obtain the best performance in dog activity, surfing, skating, and viral video domains. Finally, we show that impressive highlights can be detected without additional human supervision for seven domains (i.e., skating, surfing, skiing, gymnastics, parkour, dog activity, and viral video) in unconstrained personal videos.

  5. Highlights from the early (and pre-) history of reliability engineering

    International Nuclear Information System (INIS)

    Saleh, J.H.; Marais, K.

    2006-01-01

    Reliability is a popular concept that has been celebrated for years as a commendable attribute of a person or an artifact. From its modest beginning in 1816-the word reliability was first coined by Samuel T. Coleridge-reliability grew into an omnipresent attribute with qualitative and quantitative connotations that pervades every aspect of our present day technologically intensive world. In this short communication, we highlight key events and the history of ideas that led to the birth of Reliability Engineering, and its development in the subsequent decades. We first argue that statistics and mass production were the enablers in the rise of this new discipline, and the catalyst that accelerated the coming of this new discipline was the (unreliability of the) vacuum tube. We highlight the foundational role of AGREE report in 1957 in the birth of reliability engineering, and discuss the consolidation of numerous efforts in the 1950s into a coherent new technical discipline. We show that an evolution took place in the discipline in the following two decades along two directions: first, there was an increased specialization in the discipline (increased sophistication of statistical techniques, and the rise of a new branch focused on the actual physics of failure of components, Reliability Physics); second, there occurred a shift in the emphasis of the discipline from a component-centric to an emphasis on system-level attributes (system reliability, availability, safety). Finally, in selecting the particular events and highlights in the history of ideas that led to the birth and subsequent development of reliability engineering, we acknowledge a subjective component in this work and make no claims to exhaustiveness

  6. Heavy Vehicle Propulsion Materials Program: Progress and Highlights

    International Nuclear Information System (INIS)

    D. Ray Johnson; Sidney Diamond

    2000-01-01

    The Heavy Vehicle Propulsion Materials Program was begun in 1997 to support the enabling materials needs of the DOE Office of Heavy Vehicle Technologies (OHVT). The technical agenda for the program grew out of the technology roadmap for the OHVT and includes efforts in materials for: fuel systems, exhaust aftertreatment, valve train, air handling, structural components, electrochemical propulsion, natural gas storage, and thermal management. A five-year program plan was written in early 2000, following a stakeholders workshop. The technical issues and planned and ongoing projects are discussed. Brief summaries of several technical highlights are given

  7. Highlights of the SM Physics at the LHC

    CERN Document Server

    Yang, Haijun; The ATLAS collaboration

    2015-01-01

    This talk shows the recent highlights of the SM physics from the ATLAS and CMS experiments at the LHC. It includes the precision measurements of diboson, triboson, vector boson scattering, and indirect search for new physics via anomalous triple/quartic gauge boson couplings etc. Some latest results from LHC Run2 @ 13 TeV will also be presented. The talk was invited to present at the 5th KIAS Workshop on Particle Physics and Cosmology in Seoul on November 9-13, 2015.

  8. Clinical highlights from the 2016 European Respiratory Society International Congress

    Directory of Open Access Journals (Sweden)

    Nicolas Kahn

    2017-04-01

    Full Text Available This article contains highlights and a selection of the scientific advances from the European Respiratory Society (ERS Clinical Assembly (Assembly 1 and its six respective groups (Groups 1.1–1.6 that were presented at the 2016 ERS International Congress in London, UK. The most relevant topics for clinicians will be discussed, covering a wide range of areas including clinical problems, rehabilitation and chronic care, thoracic imaging, interventional pulmonology, diffuse and parenchymal lung diseases, and general practice and primary care. In this comprehensive review, the newest research and actual data will be discussed and put into perspective.

  9. Hot subluminous stars: Highlights from the MUCHFUSS and Kepler missions

    Directory of Open Access Journals (Sweden)

    Geier S.

    2013-03-01

    Full Text Available Research into hot subdwarf stars is progressing rapidly. We present recent important discoveries. First we review the knowledge about magnetic fields in hot subdwarfs and highlight the first detection of a highly-magnetic, helium-rich sdO star. We briefly summarize recent discoveries based on Kepler light curves and finally introduce the closest known sdB+WD binary discovered by the MUCHFUSS project and discuss its relevance as a progenitor of a double-detonation type Ia supernova.

  10. Realizing a Clean Energy Future: Highlights of NREL Analysis (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2013-12-01

    Profound energy system transformation is underway. In Hawaiian mythology, Maui set out to lasso the sun in order to capture its energy. He succeeded. That may have been the most dramatic leap forward in clean energy systems that the world has known. Until now. Today, another profound transformation is underway. A combination of forces is taking us from a carbon-centric, inefficient energy system to one that draws from diverse energy sources - including the sun. NREL analysis is helping guide energy systems policy and investment decisions through this transformation. This brochure highlights NREL analysis accomplishments in the context of four thematic storylines.

  11. Status, performance and scientific highlights from the MAGIC telescope system

    Energy Technology Data Exchange (ETDEWEB)

    Doert, Marlene [Technische Universitaet Dortmund (Germany); Ruhr-Universitaet Bochum (Germany); Collaboration: MAGIC-Collaboration

    2015-07-01

    The MAGIC telescopes are a system of two 17 m Imaging Air Cherenkov Telescopes, which are located at 2200 m above sea level at the Roque de Los Muchachos Observatory on the Canary Island of La Palma. In this presentation, we report on recent scientific highlights gained from MAGIC observations in the galactic and the extragalactic regime. We also present the current status and performance of the MAGIC system after major hardware upgrades in the years 2011 to 2014 and give an overview of future plans.

  12. Two interesting cases highlighting an oblivious specialty of psychoneuroendocrinology.

    Science.gov (United States)

    Hari Kumar, K V S; Dhull, Pawan; Somasekharan, Manoj; Seshadri, K

    2012-01-01

    Psychoneuroendocrinology deals with the overlap disorders pertaining to three different specialties. Awareness about the somatic manifestations of psychiatric diseases and vice versa is a must for all the clinicians. The knowledge of this interlinked specialty is essential because of the obscure presentation of certain disorders. Our first case was treated as depressive disorder, whereas the diagnosis was hypogonadism with empty sella. Our second patient was managed as schizophrenia and the evaluation revealed bilateral basal ganglia calcification and a diagnosis of Fahr's disease. We report these cases for their unusual presentation and to highlight the importance of this emerging specialty.

  13. 50 years of Dutch immunology--founders, institutions, highlights.

    Science.gov (United States)

    Gmelig-Meyling, Frits H J; Meyaard, Linde; Mebius, Reina E

    2014-12-01

    At the occasion of the 50th anniversary of the Dutch Society for Immunology (DSI, de Nederlandse Vereniging voor Immunologie), this contribution deals with some highlights of 50 years of Immunology in the Netherlands. It narrates about the founders and first board members of the DSI, their institutes, progeny and patrimony, describes major centers of immunological activities, mentions key persons in the field, and touches upon some events dear to the Society and its members. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Highlights of SPring-8 BL23SU in 2001

    CERN Document Server

    Agui, A; Nakatani, T; Yokoya, A; Yoshigoe, A

    2002-01-01

    BL23SU in SPring-8 is a soft x-ray beamline for the material science project in JAERI. The insertion device, monochromator and other beamline equipments have been installed or developed. The beamline maintenance has also been continued. We report highlights of these activities for the BL23SU in 2001. Specially, it has proceeded with the countermeasure against the rise in the maximum radiant power, toward the low-energy operation realization. And, improvement in that precision proceeds through the COD correlation to the ID drive as well.

  15. Princeton Plasma Physics Laboratory for FY2003. Annual Highlights

    International Nuclear Information System (INIS)

    Phillips, Carol A.; DeMeo, Anthony R.

    2004-01-01

    The Princeton Plasma Physics Laboratory FY2003 Annual Highlights report provides a summary of the activities at the Laboratory for the fiscal year--1 October 2002 through 30 September 2003. The report includes the Laboratory's Mission and Vision Statements, a message ''From the Director,'' summaries of the research and engineering activities by project, and sections on Technology Transfer, the Graduate and Science Education Programs, Awards and Honors garnered by the Laboratory and the employees, and the Year in Pictures. There is also a listing of the Laboratory's publications for the year and a section of the abbreviations, acronyms, and symbols used throughout the report. In the PDF document, links have been created from the Table of Contents to each section. You can also return to the Table of Contents from the beginning page of each section. The PPPL Highlights for fiscal year 2003 is also available in hardcopy format. To obtain a copy e-mail Publications and Reports at: pub-reports at pppl.gov. Be sure to include your complete mailing address

  16. Coated Particle and Deep Burn Fuels Monthly Highlights December 2010

    International Nuclear Information System (INIS)

    Snead, Lance Lewis; Bell, Gary L.; Besmann, Theodore M.

    2011-01-01

    During FY 2011 the CP and DB Program will report Highlights on a monthly basis, but will no longer produce Quarterly Progress Reports. Technical details that were previously included in the quarterly reports will be included in the appropriate Milestone Reports that are submitted to FCRD Program Management. These reports will also be uploaded to the Deep Burn website. The Monthly Highlights report for November 2010, ORNL/TM-2010/323, was distributed to program participants on December 9, 2010. The final Quarterly for FY 2010, Deep Burn Program Quarterly Report for July - September 2010, ORNL/TM-2010/301, was announced to program participants and posted to the website on December 28, 2010. This report discusses the following: (1) Thermochemical Data and Model Development - (a) Thermochemical Modeling, (b) Core Design Optimization in the HTR (high temperature helium-cooled reactor) Pebble Bed Design (INL), (c) Radiation Damage and Properties; (2) TRISO (tri-structural isotropic) Development - (a) TRU (transuranic elements) Kernel Development, (b) Coating Development; (3) LWR Fully Ceramic Fuel - (a) FCM Fabrication Development, (b) FCM Irradiation Testing (ORNL); (4) Fuel Performance and Analytical Analysis - Fuel Performance Modeling (ORNL).

  17. Princeton Plasma Physics Laboratory FY2003 Annual Highlights

    Energy Technology Data Exchange (ETDEWEB)

    Editors: Carol A. Phillips; Anthony R. DeMeo

    2004-08-23

    The Princeton Plasma Physics Laboratory FY2003 Annual Highlights report provides a summary of the activities at the Laboratory for the fiscal year--1 October 2002 through 30 September 2003. The report includes the Laboratory's Mission and Vision Statements, a message ''From the Director,'' summaries of the research and engineering activities by project, and sections on Technology Transfer, the Graduate and Science Education Programs, Awards and Honors garnered by the Laboratory and the employees, and the Year in Pictures. There is also a listing of the Laboratory's publications for the year and a section of the abbreviations, acronyms, and symbols used throughout the report. In the PDF document, links have been created from the Table of Contents to each section. You can also return to the Table of Contents from the beginning page of each section. The PPPL Highlights for fiscal year 2003 is also available in hardcopy format. To obtain a copy e-mail Publications and Reports at: pub-reports@pppl.gov. Be sure to include your complete mailing address

  18. CO2 Emissions From Fuel Combustion. Highlights. 2013 Edition

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-01

    In the lead-up to the UN climate negotiations in Warsaw, the latest information on the level and growth of CO2 emissions, their source and geographic distribution will be essential to lay the foundation for a global agreement. To provide input to and support for the UN process, the IEA is making available for free download the ''Highlights'' version of CO2 Emissions from Fuel Combustion now for sale on IEA Bookshop. This annual publication contains, for more than 140 countries and regions: estimates of CO2 emissions from 1971 to 2011; selected indicators such as CO2/GDP, CO2/capita, CO2/TPES and CO2/kWh; a decomposition of CO2 emissions into driving factors; and CO2emissions from international marine and aviation bunkers, key sources, and other relevant information. The nineteenth session of the Conference of the Parties to the Climate Change Convention (COP-19), in conjunction with the ninth meeting of the Parties to the Kyoto Protocol (CMP 9), met in Warsaw, Poland from 11 to 22 November 2013. This volume of ''Highlights'', drawn from the full-scale study, was specially designed for delegations and observers of the meeting in Warsaw.

  19. The controlled vitrification/crystallisation process applied

    Directory of Open Access Journals (Sweden)

    Romero, M.

    2000-02-01

    Full Text Available The glass-ceramic process, as well as the usual processing of ceramic and vitreous materials, is being investigated as a promising way for isolation and recycling of both mineral wastes (debris and mineral residues, clearings in public works and inorganic industrial wastes (muds, slags, fly ashes. Synthetic materials with useful properties to be used as building materials have been prepared from inorganic wastes of different type (red muds from zinc hydrometalurgy, fly ashes from power thermal stations, slags and fly ashes from domiciliary incinerators as well as from mixtures of such wastes with other raw materials. The obtained results allow us to conclude that the ceramic and glass-ceramic processes are outlined as an useful alternative to solve the social and environmental problems associated to wastes production.

    El proceso vitrocerámico, así como el procesado habitual de materiales cerámicos y vítreos, está siendo actualmente investigado como una prometedora vía para el aislamiento, inertización e incluso el reciclado de residuos minerales (escombreras y estériles de minas, desmontes de Obras Públicas, etc... e industriales (lodos, fangos, escorias, cenizas, etc.... A partir de residuos inorgánicos de diferente naturaleza (lodos de la hidrometalurgia del zinc, cenizas de centrales térmicas, escorias y cenizas de plantas incineradoras así como de mezclas de los mismos con otras materias primas, se están obteniendo materiales sintéticos con amplias aplicaciones en la Construcción y en Obras Públicas. Los resultados que se están consiguiendo permiten concluir que los procesos cerámico y vitrocerámico se perfilan como una alternativa real y útil para resolver, al menos parcialmente, los problemas sociales y medioambientales asociados a la producción de dichos residuos.

  20. Highlights of top quark cross-section measurements at ATLAS

    Directory of Open Access Journals (Sweden)

    Berta Peter

    2017-01-01

    Full Text Available The highlights of the measurements of top quark production in proton-proton collisions at the Large Hadron Collider with the ATLAS detector are presented. The inclusive measurements of the top-pair production cross section have reached high precision and are compared to the best available theoretical calculations. The differential cross section measurements, including results using boosted top quarks, probe our understanding of top-pair production in the TeV regime. The results are compared to Monte Carlo generators implementing LO and NLO matrix elements matched with parton showers. Measurements of the single top quark production cross section are presented in the t-channel and s-channel, and with associated production with a W boson. For the t-channel production, results on the ratio between top quark and antitop quark production cross sections and differential measurements are also included.

  1. Mobile learning and high-lighting language education

    DEFF Research Database (Denmark)

    Vinther, Jane

    Mobile learning and high-profiling language education. The number of students learning a second or foreign language and participating in instruction in languages other than English has been in decline for some time. There seems to be such a general tendency across nations albeit for a variety...... of reasons idiosyncratic to the particular national conditions. This paper gives an account of a diversified national project designed to infuse foreign language learning classes in upper secondary schools in Denmark with renewed enthusiasm through systematically experimenting with the new media by taking...... advantage of the social side in their application. The aim has been to make language classes attractive and relevant and to highlight the attractiveness and fun in learning through web 2.0 and mobile units. The overall project was supported by the Danish ministry of education as well as the individual...

  2. LHC highlights from ATLAS - FRAPWS2016 conference - Claudio Luci

    CERN Document Server

    Luci, Claudio; The ATLAS collaboration

    2016-01-01

    I am going to give a talk about highlight from ATLAS. The conference is FRAP2016, it is a conference of astrophysics. My talk is the third one oon the first day, after a general talk and one about dark matter search at colliders (given by someone does not working in atlas or cms). There is not a talk given by a colleague from cms, so mine is the only one about lhc. I have prepared my slides thinking about a "general" public and not for a specialized audience like the one we use to give talks. I have 30 minutes, maybe I have too many slides but I can easily keep the ones about dark matter if I am going to run late.

  3. Some highlights of research and development at AECL

    International Nuclear Information System (INIS)

    Langford, W.J.; Rae, H.K.

    1980-06-01

    The research and development programs of AECL have as their goal the strengthening of the knowledge and ability necessary to achieve national objectives in the field of nuclear energy. These objectives include a nuclear reactor system appropriate to Canada's industrial capabilities, now realized, and the extension of that system, through scientific and technological development, to serve the nation's needs for the forseeable future. The Company's programs are carefully integrated and focused to use the available funding to maximum advantage. The research facilities on which the program depends are among the best in the world, and support a full spectrum of research from fundamental nuclear physics to full-scale power reactor component irradiation and testing. In this report it has only been possible to high-light some important facets of the programs in each of the principal areas currently employing our energies. (auth)

  4. FY 1995 research highlights: PNL accomplishments in OER programs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    Pacific Northwest Laboratory (PNL) conducts fundamental and applied research in support of the US Department of Energy`s (DOE) core missions in science and technology, environmental quality, energy resources, and national security. Much of this research is funded by the program offices of DOE`s Office of Energy Research (DOE-ER), primarily the Office of Basic Energy Sciences (BES) and the Office of Health and Environmental Research (OHER), and by PNL`s Laboratory Directed Research and Development (LDRD) Program. This document is a collection of research highlights that describe PNL`s accomplishments in DOE-ER funded programs during Fiscal Year 1995. Included are accomplishments in research funded by OHER`s Analytical Technologies, Environmental Research, Health Effects, General Life Sciences, and Carbon Dioxide Research programs; BES`s Materials Science, Chemical Sciences, Engineering and Geoscience, and Applied Mathematical Sciences programs; and PNL`s LDRD Program. Summaries are given for 70 projects.

  5. CO2 Emissions from Fuel Combustion 2011: Highlights

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    How much CO2 are countries emitting? Where is it coming from? In the lead-up to the UN climate negotiations in Durban, the latest information on the level and growth of CO2 emissions, their source and geographic distribution will be essential to lay the foundation for a global agreement. To provide input to and support for the UN process the IEA is making available for free download the 'Highlights' version of CO2 Emissions from Fuel Combustion. This annual publication contains: - estimates of CO2 emissions by country from 1971 to 2009; - selected indicators such as CO2/GDP, CO2/capita, CO2/TPES and CO2/kWh; - CO2 emissions from international marine and aviation bunkers, and other relevant information. These estimates have been calculated using the IEA energy databases and the default methods and emission factors from the Revised 1996 IPCC Guidelines for National Greenhouse Gas Inventories.

  6. CO2 Emissions from Fuel Combustion - 2012 Highlights

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    How much CO2 are countries emitting? Where is it coming from? In the lead-up to the UN climate negotiations in Doha, the latest information on the level and growth of CO2 emissions, their source and geographic distribution will be essential to lay the foundation for a global agreement. To provide input to and support for the UN process the IEA is making available for free download the 'Highlights' version of CO2 Emissions from Fuel Combustion. This annual publication contains: estimates of CO2 emissions by country from 1971 to 2010; selected indicators such as CO2/GDP, CO2/capita, CO2/TPES and CO2/kWh; and CO2 emissions from international marine and aviation bunkers, and other relevant information.

  7. Technology meets research 60 years of CERN technology : selected highlights

    CERN Document Server

    Taylor, Thomas; Treille, Daniel; Wenninger, Horst

    2017-01-01

    "Big" science and advanced technology are known to cross-fertilize. This book emphasizes the interplay between particle physics and technology at CERN that has led to breakthroughs in both research and technology over the laboratory's first 60 years. The innovations, often the work of individuals or by small teams, are illustrated with highlights describing selected technologies from the domains of accelerators and detectors. The book also presents the framework and conditions prevailing at CERN that enabled spectacular advances in technology and contributed to propel the European organization into the league of leading research laboratories in the world. While the book is specifically aimed at providing information for the technically interested general public, more expert readers may also appreciate the broad variety of subjects presented. Ample references are given for those who wish to further explore a given topic.

  8. SUPPORTING LEARNING THROUGH EPISTEMIC SCAFFOLDS EMBEDDED IN A HIGHLIGHTER TOOL

    Directory of Open Access Journals (Sweden)

    Jan Erik Dahl

    2016-11-01

    Full Text Available This article explores the use of epistemic scaffolds embedded in a digital highlighter tool that was used to support students’ readings and discussions of research articles. The use of annotation technologies in education is increasing, and annotations can play a wide variety of epistemic roles; e.g., they can facilitate a deeper level of engagement, support critical thinking, develop cognitive and metacognitive skills and introduce practices that can support knowledge building and independent learning. However, research has shown that the actual tool use often deviates from the underlying knowledge model in the tools. Hence, the situated and mediated nature of these tools is still poorly understood. Research also tends to study the tools as a passed on resource rather than being co-constructed between students and teachers. The researcher argues that approaching these resources as co-constructed can be more productive and can create new spaces for teacher–student dialogues, students’ agency and self-scaffolding.

  9. Highlights of contractor initiatives in quality enhancement and productivity improvement

    Science.gov (United States)

    1986-01-01

    The NASA/Contractor Team efforts are presented as part of NASA's continuing effort to facilitate the sharing of quality and productivity improvement ideas among its contractors. This complilation is not meant to be a comprehensive review of contractor initiative nor does it necessarily express NASA's views. The submissions represent samples from a general survey, and were not edited by NASA. The efforts are examples of quality and productivity programs in private industry, and as such, highlight company efforts in individual areas. Topics range from modernization of equipment, hardware, and technology to management of human resources. Of particular interest are contractor initiatives which deal with measurement and evaluation data pertaining to quality and productivity performance.

  10. CO2 Emissions from Fuel Combustion 2011: Highlights

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    How much CO2 are countries emitting? Where is it coming from? In the lead-up to the UN climate negotiations in Durban, the latest information on the level and growth of CO2 emissions, their source and geographic distribution will be essential to lay the foundation for a global agreement. To provide input to and support for the UN process the IEA is making available for free download the 'Highlights' version of CO2 Emissions from Fuel Combustion. This annual publication contains: - estimates of CO2 emissions by country from 1971 to 2009; - selected indicators such as CO2/GDP, CO2/capita, CO2/TPES and CO2/kWh; - CO2 emissions from international marine and aviation bunkers, and other relevant information. These estimates have been calculated using the IEA energy databases and the default methods and emission factors from the Revised 1996 IPCC Guidelines for National Greenhouse Gas Inventories.

  11. CO2 Emissions from Fuel Combustion - 2012 Highlights

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    How much CO2 are countries emitting? Where is it coming from? In the lead-up to the UN climate negotiations in Doha, the latest information on the level and growth of CO2 emissions, their source and geographic distribution will be essential to lay the foundation for a global agreement. To provide input to and support for the UN process the IEA is making available for free download the 'Highlights' version of CO2 Emissions from Fuel Combustion. This annual publication contains: estimates of CO2 emissions by country from 1971 to 2010; selected indicators such as CO2/GDP, CO2/capita, CO2/TPES and CO2/kWh; and CO2 emissions from international marine and aviation bunkers, and other relevant information.

  12. Wildlife studies on the Hanford Site: 1993 Highlights report

    Energy Technology Data Exchange (ETDEWEB)

    Cadwell, L.L. [ed.

    1994-04-01

    The Pacific Northwest Laboratory (PNL) Wildlife Resources Monitoring Project was initiated by DOE to track the status of wildlife populations to determine whether Hanford operations affected them. The project continues to conduct a census of wildlife populations that are highly visible, economically or aesthetically important, and rare or otherwise considered sensitive. Examples of long-term data collected and maintained through the Wildlife Resources Monitoring Project include annual goose nesting surveys conducted on islands in the Hanford Reach, wintering bald eagle surveys, and fall Chinook salmon redd (nest) surveys. The report highlights activities related to salmon and mollusks on the Hanford Reach of the Columbia River; describes efforts to map vegetation on the Site and efforts to survey species of concern; provides descriptions of shrub-steppe bird surveys, including bald eagles, Canada geese, and hawks; outlines efforts to monitor mule deer and elk populations on the Site; and describes development of a biological database management system.

  13. The MeteoMet2 project—highlights and results

    Science.gov (United States)

    Merlone, A.; Sanna, F.; Beges, G.; Bell, S.; Beltramino, G.; Bojkovski, J.; Brunet, M.; del Campo, D.; Castrillo, A.; Chiodo, N.; Colli, M.; Coppa, G.; Cuccaro, R.; Dobre, M.; Drnovsek, J.; Ebert, V.; Fernicola, V.; Garcia-Benadí, A.; Garcia-Izquierdo, C.; Gardiner, T.; Georgin, E.; Gonzalez, A.; Groselj, D.; Heinonen, M.; Hernandez, S.; Högström, R.; Hudoklin, D.; Kalemci, M.; Kowal, A.; Lanza, L.; Miao, P.; Musacchio, C.; Nielsen, J.; Nogueras-Cervera, M.; Oguz Aytekin, S.; Pavlasek, P.; de Podesta, M.; Rasmussen, M. K.; del-Río-Fernández, J.; Rosso, L.; Sairanen, H.; Salminen, J.; Sestan, D.; Šindelářová, L.; Smorgon, D.; Sparasci, F.; Strnad, R.; Underwood, R.; Uytun, A.; Voldan, M.

    2018-02-01

    Launched in 2011 within the European Metrology Research Programme (EMRP) of EURAMET, the joint research project ‘MeteoMet’—Metrology for Meteorology—is the largest EMRP consortium; national metrology institutes, universities, meteorological and climate agencies, research institutes, collaborators and manufacturers are working together, developing new metrological techniques, as well as improving existing ones, for use in meteorological observations and climate records. The project focuses on humidity in the upper and surface atmosphere, air temperature, surface and deep-sea temperatures, soil moisture, salinity, permafrost temperature, precipitation, and the snow albedo effect on air temperature. All tasks are performed using a rigorous metrological approach and include the design and study of new sensors, new calibration facilities, the investigation of sensor characteristics, improved techniques for measurements of essential climate variables with uncertainty evaluation, traceability, laboratory proficiency and the inclusion of field influencing parameters, long-lasting measurements, and campaigns in remote and extreme areas. The vision for MeteoMet is to take a step further towards establishing full data comparability, coherency, consistency, and long-term continuity, through a comprehensive evaluation of the measurement uncertainties for the quantities involved in the global climate observing systems and the derived observations. The improvement in quality of essential climate variables records, through the inclusion of measurement uncertainty budgets, will also highlight possible strategies for the reduction of the uncertainty. This contribution presents selected highlights of the MeteoMet project and reviews the main ongoing activities, tasks and deliverables, with a view to its possible future evolution and extended impact.

  14. Highlighting landslides and other geomorphological features using sediment connectivity maps

    Science.gov (United States)

    Bossi, Giulia; Crema, Stefano; Cavalli, Marco; Marcato, Gianluca; Pasuto, Alessandro

    2016-04-01

    Landslide identification is usually made through interpreting geomorphological features in the field or with remote sensing imagery. In recent years, airborne laser scanning (LiDAR) has enhanced the potentiality of geomorphological investigations by providing a detailed and diffuse representation of the land surface. The development of algorithms for geomorphological analysis based on LiDAR derived high-resolution Digital Terrain Models (DTMs) is increasing. Among them, the sediment connectivity index (IC) has been used to quantify sediment dynamics in alpine catchments. In this work, maps of the sediment connectivity index are used for detecting geomorphological features and processes not exclusively related to water-laden processes or debris flows. The test area is located in the upper Passer Valley in South Tyrol (Italy). Here a 4 km2 Deep-seated Gravitational Slope Deformation (DGSD) with several secondary phenomena has been studied for years. The connectivity index was applied to a well-known study area in order to evaluate its effectiveness as an interpretative layer to assist geomorphological analysis. Results were cross checked with evidence previously identified by means of in situ investigations, photointerpretation and monitoring data. IC was applied to a 2.5 m LiDAR derived DTM using two different scenarios in order to test their effectiveness: i) IC derived on the hydrologically correct DTM; ii) IC derived on the original DTM. In the resulting maps a cluster of low-connectivity areas appears as the deformation of the DGSD induce a convexity in the central part of the phenomenon. The double crests, product of the sagging of the landslide, are extremely evident since in those areas the flow directions diverge from the general drainage pattern, which is directed towards the valley river. In the crown area a rock-slab that shows clear evidence of incumbent detachment is clearly highlighted since the maps emphasize the presence of traction trenches and

  15. History highlights and future trends of infrared sensors

    Science.gov (United States)

    Corsi, Carlo

    2010-10-01

    Infrared (IR) technologies (materials, devices and systems) represent an area of excellence in science and technology and, even if they have been generally confined to a selected scientific community, they have achieved technological and scientific highlights constituting 'innovation drivers' for neighbouring disciplines, especially in the sensors field. The development of IR sensors, initially linked to astronomical observations, since World War II and for many years has been fostered essentially by defence applications, particularly thermo-vision and, later on, smart vision and detection, for surveillance and warning. Only in the last few decades, the impact of silicon technology has changed the development of IR detectors dramatically, with the advent of integrated signal read-outs and the opening of civilian markets (EO communications, biomedical, environmental, transport and energy applications). The history of infrared sensors contains examples of real breakthroughs, particularly true in the case of focal plane arrays that first appeared in the late 1970s, when the superiority of bi-dimensional arrays for most applications pushed the development of technologies providing the highest number of pixels. An impressive impulse was given to the development of FPA arrays by integration with charge coupled devices (CCD), with strong competition from different technologies (high-efficiency photon sensors, Schottky diodes, multi-quantum wells and, later on, room temperature microbolometers/cantilevers). This breakthrough allowed the development of high performance IR systems of small size, light weight and low cost - and therefore suitable for civil applications - thanks to the elimination of the mechanical scanning system and the progressive reduction of cooling requirements (up to the advent of microbolometers, capable of working at room temperature). In particular, the elimination of cryogenic cooling allowed the development and commercialisation of IR Smart Sensors

  16. Highlighting Entanglement of Cultures via Ranking of Multilingual Wikipedia Articles

    Science.gov (United States)

    Eom, Young-Ho; Shepelyansky, Dima L.

    2013-01-01

    How different cultures evaluate a person? Is an important person in one culture is also important in the other culture? We address these questions via ranking of multilingual Wikipedia articles. With three ranking algorithms based on network structure of Wikipedia, we assign ranking to all articles in 9 multilingual editions of Wikipedia and investigate general ranking structure of PageRank, CheiRank and 2DRank. In particular, we focus on articles related to persons, identify top 30 persons for each rank among different editions and analyze distinctions of their distributions over activity fields such as politics, art, science, religion, sport for each edition. We find that local heroes are dominant but also global heroes exist and create an effective network representing entanglement of cultures. The Google matrix analysis of network of cultures shows signs of the Zipf law distribution. This approach allows to examine diversity and shared characteristics of knowledge organization between cultures. The developed computational, data driven approach highlights cultural interconnections in a new perspective. Dated: June 26, 2013 PMID:24098338

  17. Wildlife studies on the Hanford site: 1994 Highlights report

    Energy Technology Data Exchange (ETDEWEB)

    Cadwell, L.L. [ed.

    1995-04-01

    The purposes of the project are to monitor and report trends in wildlife populations; conduct surveys to identify, record, and map populations of threatened, endangered, and sensitive plant and animal species; and cooperate with Washington State and federal and private agencies to help ensure the protection afforded by law to native species and their habitats. Census data and results of surveys and special study topics are shared freely among cooperating agencies. Special studies are also conducted as needed to provide additional information that may be required to assess, protect, or manage wildlife resources at Hanford. This report describes highlights of wildlife studies on the Site in 1994. Redd counts of fall chinook salmon in the Hanford Reach suggest that harvest restrictions directed at protecting Snake River salmon may have helped Columbia River stocks as well. The 1994 count (5619) was nearly double that of 1993 and about 63% of the 1989 high of approximately 9000. A habitat map showing major vegetation and land use cover types for the Hanford Site was completed in 1993. During 1994, stochastic simulation was used to estimate shrub characteristics (height, density, and canopy cover) across the previously mapped Hanford landscape. The information provided will be available for use in determining habitat quality for sensitive wildlife species. Mapping Site locations of plant species of concern continued during 1994. Additional sensitive plant species data from surveys conducted by TNC were archived. The 10 nesting pairs of ferruginous hawks that used the Hanford Site in 1993 represented approximately 25% of the Washington State population.

  18. AGILE DATA CENTER AT ASDC AND AGILE HIGHLIGHTS

    Directory of Open Access Journals (Sweden)

    Carlotta Pittori

    2013-12-01

    Full Text Available We present an overview of the main AGILE Data Center activities and the AGILE scientific highlights during the first 5 years of operations. AGILE is an ASI space mission in joint collaboration with INAF, INFN and CIFS, dedicated to the observation of the gamma-ray Universe. The AGILE satellite was launched on April 23rd, 2007, and is devoted to gamma-ray astrophysics in the 30MeV ÷ 50 GeV energy range, with simultaneous X-ray imaging capability in the 18 ÷ 60 keV band. Despite the small size and budget, AGILE has produced several important scientific results, including the unexpected discovery of strong and rapid gamma-ray flares from the Crab Nebula over daily timescales. This discovery won AGILE PI and the AGILE Team the prestigious Bruno Rossi Prize for 2012, an international award in the field of high energy astrophysics. Thanks to its sky monitoring capability and fast ground segment alert system, AGILE is substantially improving our knowledge of the gamma-ray sky, also making a crucial contribution to the study of the terrestrial gamma-ray flashes (TGFs detected in the Earth atmosphere. The AGILE Data Center, part of the ASI Science Data Center (ASDC located in Frascati, Italy, is in charge of all the science oriented activities related to the analysis, archiving and distribution of AGILE data.

  19. Wildlife studies on the Hanford site: 1994 Highlights report

    International Nuclear Information System (INIS)

    Cadwell, L.L.

    1995-04-01

    The purposes of the project are to monitor and report trends in wildlife populations; conduct surveys to identify, record, and map populations of threatened, endangered, and sensitive plant and animal species; and cooperate with Washington State and federal and private agencies to help ensure the protection afforded by law to native species and their habitats. Census data and results of surveys and special study topics are shared freely among cooperating agencies. Special studies are also conducted as needed to provide additional information that may be required to assess, protect, or manage wildlife resources at Hanford. This report describes highlights of wildlife studies on the Site in 1994. Redd counts of fall chinook salmon in the Hanford Reach suggest that harvest restrictions directed at protecting Snake River salmon may have helped Columbia River stocks as well. The 1994 count (5619) was nearly double that of 1993 and about 63% of the 1989 high of approximately 9000. A habitat map showing major vegetation and land use cover types for the Hanford Site was completed in 1993. During 1994, stochastic simulation was used to estimate shrub characteristics (height, density, and canopy cover) across the previously mapped Hanford landscape. The information provided will be available for use in determining habitat quality for sensitive wildlife species. Mapping Site locations of plant species of concern continued during 1994. Additional sensitive plant species data from surveys conducted by TNC were archived. The 10 nesting pairs of ferruginous hawks that used the Hanford Site in 1993 represented approximately 25% of the Washington State population

  20. Satellite tracking of manta rays highlights challenges to their conservation.

    Directory of Open Access Journals (Sweden)

    Rachel T Graham

    Full Text Available We describe the real-time movements of the last of the marine mega-vertebrate taxa to be satellite tracked - the giant manta ray (or devil fish, Manta birostris, the world's largest ray at over 6 m disc width. Almost nothing is known about manta ray movements and their environmental preferences, making them one of the least understood of the marine mega-vertebrates. Red listed by the International Union for the Conservation of Nature as 'Vulnerable' to extinction, manta rays are known to be subject to direct and incidental capture and some populations are declining. Satellite-tracked manta rays associated with seasonal upwelling events and thermal fronts off the Yucatan peninsula, Mexico, and made short-range shuttling movements, foraging along and between them. The majority of locations were received from waters shallower than 50 m deep, representing thermally dynamic and productive waters. Manta rays remained in the Mexican Exclusive Economic Zone for the duration of tracking but only 12% of tracking locations were received from within Marine Protected Areas (MPAs. Our results on the spatio-temporal distribution of these enigmatic rays highlight opportunities and challenges to management efforts.

  1. Satellite tracking of manta rays highlights challenges to their conservation.

    Science.gov (United States)

    Graham, Rachel T; Witt, Matthew J; Castellanos, Dan W; Remolina, Francisco; Maxwell, Sara; Godley, Brendan J; Hawkes, Lucy A

    2012-01-01

    We describe the real-time movements of the last of the marine mega-vertebrate taxa to be satellite tracked - the giant manta ray (or devil fish, Manta birostris), the world's largest ray at over 6 m disc width. Almost nothing is known about manta ray movements and their environmental preferences, making them one of the least understood of the marine mega-vertebrates. Red listed by the International Union for the Conservation of Nature as 'Vulnerable' to extinction, manta rays are known to be subject to direct and incidental capture and some populations are declining. Satellite-tracked manta rays associated with seasonal upwelling events and thermal fronts off the Yucatan peninsula, Mexico, and made short-range shuttling movements, foraging along and between them. The majority of locations were received from waters shallower than 50 m deep, representing thermally dynamic and productive waters. Manta rays remained in the Mexican Exclusive Economic Zone for the duration of tracking but only 12% of tracking locations were received from within Marine Protected Areas (MPAs). Our results on the spatio-temporal distribution of these enigmatic rays highlight opportunities and challenges to management efforts.

  2. Highlighting entanglement of cultures via ranking of multilingual Wikipedia articles.

    Directory of Open Access Journals (Sweden)

    Young-Ho Eom

    Full Text Available How different cultures evaluate a person? Is an important person in one culture is also important in the other culture? We address these questions via ranking of multilingual Wikipedia articles. With three ranking algorithms based on network structure of Wikipedia, we assign ranking to all articles in 9 multilingual editions of Wikipedia and investigate general ranking structure of PageRank, CheiRank and 2DRank. In particular, we focus on articles related to persons, identify top 30 persons for each rank among different editions and analyze distinctions of their distributions over activity fields such as politics, art, science, religion, sport for each edition. We find that local heroes are dominant but also global heroes exist and create an effective network representing entanglement of cultures. The Google matrix analysis of network of cultures shows signs of the Zipf law distribution. This approach allows to examine diversity and shared characteristics of knowledge organization between cultures. The developed computational, data driven approach highlights cultural interconnections in a new perspective. Dated: June 26, 2013.

  3. Automatic summarization of soccer highlights using audio-visual descriptors.

    Science.gov (United States)

    Raventós, A; Quijada, R; Torres, Luis; Tarrés, Francesc

    2015-01-01

    Automatic summarization generation of sports video content has been object of great interest for many years. Although semantic descriptions techniques have been proposed, many of the approaches still rely on low-level video descriptors that render quite limited results due to the complexity of the problem and to the low capability of the descriptors to represent semantic content. In this paper, a new approach for automatic highlights summarization generation of soccer videos using audio-visual descriptors is presented. The approach is based on the segmentation of the video sequence into shots that will be further analyzed to determine its relevance and interest. Of special interest in the approach is the use of the audio information that provides additional robustness to the overall performance of the summarization system. For every video shot a set of low and mid level audio-visual descriptors are computed and lately adequately combined in order to obtain different relevance measures based on empirical knowledge rules. The final summary is generated by selecting those shots with highest interest according to the specifications of the user and the results of relevance measures. A variety of results are presented with real soccer video sequences that prove the validity of the approach.

  4. Can Chimpanzee Biology Highlight Human Origin and Evolution?

    Directory of Open Access Journals (Sweden)

    Itai Roffman

    2010-07-01

    Full Text Available The closest living relatives of humans are their chimpanzee/bonobo (Pan sister species, members of the same subfamily “Homininae”. This classification is supported by over 50 years of research in the fields of chimpanzee cultural diversity, language competency, genomics, anatomy, high cognition, psychology, society, self-consciousness and relation to others, tool use/production, as well as Homo level emotions, symbolic competency, memory recollection, complex multifaceted problem-solving capabilities, and interspecies communication. Language competence and symbolism can be continuously bridged from chimpanzee to man. Emotions, intercommunity aggression, body language, gestures, facial expressions, and vocalization of intonations seem to parallel between the sister taxa Homo and Pan. The shared suite of traits between Pan and Homo genus demonstrated in this article integrates old and new information on human–chimpanzee evolution, bilateral informational and cross-cultural exchange, promoting the urgent need for Pan cultures in the wild to be protected, as they are part of the cultural heritage of mankind. Also, we suggest that bonobos, Pan paniscus, based on shared traits with Australopithecus, need to be included in Australopithecine’s subgenus, and may even represent living-fossil Australopithecines. Unfolding bonobo and chimpanzee biology highlights our common genetic and cultural evolutionary origins.

  5. Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis.

    Science.gov (United States)

    Furue, Kazuhisa; Yamamura, Kazuhiko; Tsuji, Gaku; Mitoma, Chikage; Uchi, Hiroshi; Nakahara, Takeshi; Kido-Nakahara, Makiko; Kadono, Takafumi; Furue, Masutaka

    2018-01-12

    Plaque psoriasis and pustular psoriasis are overlapping, but distinct, disorders. The therapeutic response to biologics supports the pivotal role of the tumour necrosis alpha (TNF-?)/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these disorders. Recently, functional activation of the IL-36 receptor (IL-36R) was discovered to be another driving force in the pathogenesis of psoriasis. This was first highlighted by the discovery that a loss-of-function mutation of the IL-36R antagonist (IL-36Ra) causes pustular psoriasis. Although the TNF-?/IL-23/IL-17/IL-22 axis and the functional activation of IL-36R are fundamentally involved in plaque psoriasis and pustular psoriasis, respectively, the 2 pathways are closely related and mutually reinforced, resulting in full-blown clinical manifestations. This review summarizes current topics on how IL-36 agonists (IL-36?, IL-36?, IL-36?) signal IL-36R, the pathological expression of IL-36 agonists and IL-36Ra in plaque and pustular psoriatic lesions, and the cross-talk between the TNF-?/IL-23/IL-17/IL-22 axis and the functional activation of IL-36R in the epidermal milieu.

  6. Pre-accidental situations highlighted by RECUPERARE method and data

    Energy Technology Data Exchange (ETDEWEB)

    Matahri, N. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Fontenay-aux-Roses (France)

    2006-07-01

    RECUPERARE method has been developed for operating feedback analysis and built on the French Human Reliability Analysis (HRA) principles. It is used to study the causes of human errors or technical failures occurred in French PWRs and the recovery process of events. Based on an event classification (6 categories) model according to the nature of the link between failure and recovery, the identified and recorded data are: the causes of the defects (technical, human, organizational) and the context in which they appear; the factors of the recovery performance (depending on technical and organizational aspects); a chronological analysis, designed to collect delays between failures and their detection/recovery for each event. About 3600 events reported in French PWRs (1997-2003) had been reviewed through this model. Initially, the weight of factors and the most important factors, which influenced the detection and recovery delay, are defined. For this purpose, the regression Partial Least Square (PLS) is used. Then, to link RECUPERARE results with pre-accidental data, conditional probabilities of events linked between them by a cause and effect relationship are calculated. For this, the Bayesian method with the Bayesian network is built with the PLS obtained results and applied. This constitutes a first approach to take into account in HRA the human and organizational factors highlighted by operating feedback. (author)

  7. Alberta Energy and Utilities Board, regulatory highlights for 1998

    International Nuclear Information System (INIS)

    1999-01-01

    This new publication informs readers about what the Alberta Energy and Utilities Board (EUB) did in the past year, including important regulatory issues, trends and initiatives. The EUB is an agency of the provincial government, established to regulate Alberta's energy resource and utility sectors. It is part of the Alberta Ministry of Energy. The four main functions of the Board are regulatory initiatives, license applications, enforcement and information. This publication summarized the EUB's position regarding flaring (both solution gas flaring and well test flaring), and Board activities in the areas of animal health concerns, the gas over bitumen controversy, the deregulation of the electric industry and what it means to the EUB, improvements in data quality as a result of improved industry compliance in reporting, and a variety of issues related to the oil sands and the negotiated settlement process. Also, the Board has been proactive in the area of oilfield waste management guidelines, proliferation policies for gas processing facilities, sulphur recovery guidelines, and the expansion of the orphan well program to include facilities and pipelines. As a measure of the success of the EUB, a recent survey of 19 randomly selected focus groups praised EUB for its impartiality, fair and equitable enforcement and independence. It was also praised for its technically competent and experienced staff, its access to quality information and the clarity of its mandate, regulatory requirements and processes. The Board's efforts in the area of timely stakeholder consultation was highlighted. tabs., figs

  8. Alberta Energy and Utilities Board, regulatory highlights for 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-08-01

    This new publication informs readers about what the Alberta Energy and Utilities Board (EUB) did in the past year, including important regulatory issues, trends and initiatives. The EUB is an agency of the provincial government, established to regulate Alberta`s energy resource and utility sectors. It is part of the Alberta Ministry of Energy. The four main functions of the Board are regulatory initiatives, license applications, enforcement and information. This publication summarized the EUB`s position regarding flaring (both solution gas flaring and well test flaring), and Board activities in the areas of animal health concerns, the gas over bitumen controversy, the deregulation of the electric industry and what it means to the EUB, improvements in data quality as a result of improved industry compliance in reporting, and a variety of issues related to the oil sands and the negotiated settlement process. Also, the Board has been proactive in the area of oilfield waste management guidelines, proliferation policies for gas processing facilities, sulphur recovery guidelines, and the expansion of the orphan well program to include facilities and pipelines. As a measure of the success of the EUB, a recent survey of 19 randomly selected focus groups praised EUB for its impartiality, fair and equitable enforcement and independence. It was also praised for its technically competent and experienced staff, its access to quality information and the clarity of its mandate, regulatory requirements and processes. The Board`s efforts in the area of timely stakeholder consultation was highlighted. tabs., figs.

  9. Binary Paths to Type Ia Supernovae Explosions: the Highlights

    Science.gov (United States)

    Ferrario, Lilia

    2013-01-01

    This symposium was focused on the hunt for the progenitors of Type Ia supernovae (SNe Ia). Is there a main channel for the production of SNe Ia? If so, are these elusive progenitors single degenerate or double degenerate systems? Although most participants seemed to favor the single degenerate channel, there was no general agreement on the type of binary system at play. An observational puzzle that was highlighted was the apparent paucity of supersoft sources in our Galaxy and also in external galaxies. The single degenerate channel (and as it was pointed out, quite possibly also the double degenerate channel) requires the binary system to pass through a phase of steady nuclear burning. However, the observed number of supersoft sources falls short by a factor of up to 100 in explaining the estimated birth rates of SNe Ia. Thus, are these supersoft sources somehow hidden away and radiating at different wavelengths, or are we missing some important pieces of this puzzle that may lead to the elimination of a certain class of progenitor? Another unanswered question concerns the dependence of SNe Ia luminosities on the age of their host galaxy. Several hypotheses were put forward, but none was singled out as the most likely explanation. It is fair to say that at the end of the symposium the definitive answer to the vexed progenitor question remained well and truly wide open.

  10. Highlights from PHENIX transverse spin program at RHIC

    International Nuclear Information System (INIS)

    Liu, M.

    2013-01-01

    In recent years, there has been exciting development in both experimental and theoretical studies of transverse spin phenomena in high energy polarized p+p and polarized DIS collisions. In the p+p frontier, the polarized p+p collider at RHIC provides a unique opportunity to investigate the novel physics that causes the large spin effects seen in the transversely polarized p+p collisions over the past 30 years, particularly in the forward rapidity. Since the beginning, PHENIX has been conducting a very active transverse spin physics program to study Sivers, Collins and other novel spin effects at RHIC, including measurements of transverse single spin asymmetry (TSSA) in light and heavy quark productions, leading neutron TSSA in the very forward rapidity, and di-hadron (and 'jet') spin correlations in a wide kinematics range, just to name a few. In 2012, PHENIX collected transversely polarized 200 GeV p+p data with a record high luminosity of 9.24 pb −1 , with an average beam polarization of 58%. In this talk, I highlight the recent results from the PHENIX experiment, and also briefly discuss the near-term prospects of new transverse spin measurements only possible with the latest (forward) silicon vertex detectors, (F)VTX, and the upcoming forward MPC-EX upgrade detectors.

  11. Pre-accidental situations highlighted by RECUPERARE method and data

    International Nuclear Information System (INIS)

    Matahri, N.

    2006-01-01

    RECUPERARE method has been developed for operating feedback analysis and built on the French Human Reliability Analysis (HRA) principles. It is used to study the causes of human errors or technical failures occurred in French PWRs and the recovery process of events. Based on an event classification (6 categories) model according to the nature of the link between failure and recovery, the identified and recorded data are: the causes of the defects (technical, human, organizational) and the context in which they appear; the factors of the recovery performance (depending on technical and organizational aspects); a chronological analysis, designed to collect delays between failures and their detection/recovery for each event. About 3600 events reported in French PWRs (1997-2003) had been reviewed through this model. Initially, the weight of factors and the most important factors, which influenced the detection and recovery delay, are defined. For this purpose, the regression Partial Least Square (PLS) is used. Then, to link RECUPERARE results with pre-accidental data, conditional probabilities of events linked between them by a cause and effect relationship are calculated. For this, the Bayesian method with the Bayesian network is built with the PLS obtained results and applied. This constitutes a first approach to take into account in HRA the human and organizational factors highlighted by operating feedback. (author)

  12. Radio Astronomy at TIFR, some highlights and reminiscences

    Science.gov (United States)

    Swarup, G.

    Radio astronomy research was initiated at TIFR fifty years ago. In this historical article, I firstly trace my initiation in the field of radio astronomy during 1953-55 in the Radio Physics Laboratory of CSIRO in Australia and later during 1956-63 in USA. In September 1961, four radio astronomers working abroad wrote to a number of scientific organizations in India with their desire to start radio astronomy research in India. Soon thereafter Dr. Homi Bhabha, the founder Director of TIFR, approved the formation of a radio astronomy group therein. I joined TIFR in April 1963. During the last 50 years, TIFR has built two of the world's largest radio telescopes, namely the 530m long and 30 m wide parabolic cylinder equatorially mounted on a hill at Ooty in South India during 1960s and the Giant Metrewave Radio Telescope near Pune, consisting of 30 nos. of fully steerable parabolic dishes of 45 m diameters during 1990s. Fifty years of radio astronomy research at TIFR is briefly highlighted here.

  13. Atomic Auger spectroscopy: Historical perspective and recent highlights

    International Nuclear Information System (INIS)

    Mehlhorn, W.

    2000-01-01

    The non-radiating decay of an inner-shell ionized atom by the emission of an electron was discovered by Pierre Auger in cloud-chamber experiments in the years 1923 to 1926. The first spectroscopic investigation of Auger electrons was performed by Robinson and Cassie in 1926, marking the birth date of Auger spectroscopy. The following seven decades of Auger spectroscopy will be divided into three periods. In the first period (1926-1960) Auger spectroscopy was mainly connected with β-ray spectroscopy where inner-shell ionization of atoms in the solid state was caused either by γ-conversion or by electron capture. The second period (beginning in 1960) is characterized by the external excitation of gas-phase or free metallic atoms, opening Auger spectroscopy to electron energies in the range of few eV to few keV. The third period (beginning in 1977/78) is characterized by the use of synchrotron radiation with its outstanding properties of tunability, polarization and narrow-band high intensity for the excitation and ionization of inner-shell electrons. Finally, two recent highlights of Auger spectroscopy, the interference between photo- and Auger electron with equal energies and an 'almost' complete experiment for Auger decay, will be presented

  14. Students' reflections in a portfolio pilot: highlighting professional issues.

    Science.gov (United States)

    Haffling, Ann-Christin; Beckman, Anders; Pahlmblad, Annika; Edgren, Gudrun

    2010-01-01

    Portfolios are highlighted as potential assessment tools for professional competence. Although students' self-reflections are considered to be central in the portfolio, the content of reflections in practice-based portfolios is seldom analysed. To investigate whether students' reflections include sufficient dimensions of professional competence, notwithstanding a standardized portfolio format, and to evaluate students' satisfaction with the portfolio. Thirty-five voluntary final-year medical students piloted a standardized portfolio in a general practice (GP) attachment at Lund University, Sweden. Students' portfolio reflections were based upon documentary evidence from practice, and aimed to demonstrate students' learning. The reflections were qualitatively analysed, using a framework approach. Students' evaluations of the portfolio were subjected to quantitative and qualitative analysis. Among professional issues, an integration of cognitive, affective and practical dimensions in clinical practice was provided by students' reflections. The findings suggested an emphasis on affective issues, particularly on self-awareness of feelings, attitudes and concerns. In addition, ethical problems, clinical reasoning strategies and future communication skills training were subjects of several reflective commentaries. Students' reflections on their consultation skills demonstrated their endeavour to achieve structure in the medical interview by negotiation of an agenda for the consultation, keeping the interview on track, and using internal summarizing. The importance of active listening and exploration of patient's perspective was also emphasized. In students' case summaries, illustrating characteristic attributes of GP, the dominating theme was 'patient-centred care', including the patient-doctor relationship, holistic modelling and longitudinal continuity. Students were satisfied with the portfolio, but improved instructions were needed. A standardized portfolio in a

  15. Dissection of protein interactomics highlights microRNA synergy.

    Science.gov (United States)

    Zhu, Wenliang; Zhao, Yilei; Xu, Yingqi; Sun, Yong; Wang, Zhe; Yuan, Wei; Du, Zhimin

    2013-01-01

    Despite a large amount of microRNAs (miRNAs) have been validated to play crucial roles in human biology and disease, there is little systematic insight into the nature and scale of the potential synergistic interactions executed by miRNAs themselves. Here we established an integrated parameter synergy score to determine miRNA synergy, by combining the two mechanisms for miRNA-miRNA interactions, miRNA-mediated gene co-regulation and functional association between target gene products, into one single parameter. Receiver operating characteristic (ROC) analysis indicated that synergy score accurately identified the gene ontology-defined miRNA synergy (AUC = 0.9415, psynergy, implying poor expectancy of widespread synergy. However, targeting more key genes made two miRNAs more likely to act synergistically. Compared to other miRNAs, miR-21 was a highly exceptional case due to frequent appearance in the top synergistic miRNA pairs. This result highlighted its essential role in coordinating or strengthening physiological and pathological functions of other miRNAs. The synergistic effect of miR-21 and miR-1 were functionally validated for their significant influences on myocardial apoptosis, cardiac hypertrophy and fibrosis. The novel approach established in this study enables easy and effective identification of condition-restricted potent miRNA synergy simply by concentrating the available protein interactomics and miRNA-target interaction data into a single parameter synergy score. Our results may be important for understanding synergistic gene regulation by miRNAs and may have significant implications for miRNA combination therapy of cardiovascular disease.

  16. Highlights on searches for supersymmetry and exotic models

    International Nuclear Information System (INIS)

    Clerbaux, B.

    2015-01-01

    In this review, we present highlight results of the first three years of the LHC running on searches for new physics beyond the Standard Model (BSM). The excellent performance of the LHC machine and detectors has provided a large, high-quality dataset, mainly proton-proton interactions at a centre of mass energy of 7 TeV (collected in 2010 and 2011) and 8 TeV (collected in 2012). This allowed the experiments to test the Standard Model (SM) at the highest available energy and to search for new phenomena in a considerably enlarged phase space compared to previous colliders. The present review is organised as follows. Section 2 gives motivations to search for new physics beyond the SM, and a brief description of the main classes of BSM theory candidates is reported in Section 3. Section 4 summarises the characteristics of the 3-year LHC dataset, called in the following the Run 1 dataset. Precise tests of the SM are reported in Section 5. The following next sections are the core of the review and present a selection of results from the ATLAS and CMS experiments on BSM searches, gathered in four parts: the search for new physics in the scalar sector in Section 6, the search for supersymmetric particles in Section 7, the search for dark matter candidates in Section 8, and a non-exhaustive list of other exotics BSM (heavy resonances, excited fermions, leptoquarks and vector-like quarks) searches in Section 9. Future plans of the LHC running are reported in Section 10

  17. Highlights of IAEA activities in the field of radiation application

    International Nuclear Information System (INIS)

    Machi, S.

    1994-01-01

    In IAEA's major programme of Nuclear Applications, the activities performed are divided into four areas: food and agriculture, industry and earth science, human health, and physical and chemical sciences. These activities involve co-operation with FAO, WHO, UNIDO and UNEP, and have close link with the technical assistance programme. About 60% of the technical assistance projects are implemented in the field of nuclear applications. The purpose of the nuclear application programme is to develop technologies useful for environmental protection and sustainable development, to support R and D programmes of developing countries, to develop new applications of nuclear techniques. Major activities in food and agriculture are the application of radiation and isotopes, controling insects, preserving food, soil fertility and crop production, and improving animal production and the use of radiation with biotechnology for plant mutation breeding aiming at environmentally friendly and sustainable food production. In the human health programme emphasis is given to nuclear medicine, cancer therapy and nutrition. Today, only 35% of all developing countries have radiotherapy facilities. Activities, therefore, focus on strengthening clinical radiotherapy in such countries. In the field of industry and earth science, flue gas cleaning by electron beams, pollution monitoring using nuclear analytical techniques, nucleonic control systems for industries, and water resource exploration are major projects assisting developing countries. As of 1994 the IAEA will launch 12 new and promising Model Projects for developing Member States which will be of benefit to their economies and raising of their standard of living. In this paper the highlights of the above mentioned IAEA activities are presented. (author)

  18. Current Highlights on ESA's Planetary Technology Reference Studies

    Science.gov (United States)

    Falkner, P.

    The concept of Technology Reference Studies has been introduced already at EGU05, where the Venus Entry Probe (VEP), the Jupiter Minisat Explorer (JME), the Deimos Sample Return (DSR) and the Interstellar Heliopause Probe (IHP) have been presented in detail. At the EGU06 the new studies in reaction to the Cosmic Vision exercise have been introduced. The formulation of themes and mapping into potential future missions has been taken as basis in the planning of additional new and adaptation of existing TRS's to cover areas, which have not yet been addressed by any TRS. These new ongoing studies are progressing well and current highlights will be presented in the paper in further detail as well as an overview on supporting technology studies and Concurrent Design Facility (CDF) sessions. The Jupiter System Explorer (JSE) study investigates mission concepts with up to two Magnetospheric Orbiters placed in a highly elliptical Jovian orbit and the possibility to deploy a Jovian Entry Probe. The mission profile is based on a solar powered concept launched on a Soyuz-Fregat launcher. Mission analysis and the application of a new Jovian radiation model are supporting the study activities. The Near-Earth Asteroid Sample Return (NEA-SR) concept explores the possibilities of sample return or in-situ mission profiles with visits to up to two NEA targets. Due to the assumed low cost cap a trade between a sample return and remote/in-situ exploration concept has a high attention in the study. The Cross Scale TRS (CS-TRS) is intended to simultaneously investigate magnetospheric and plasma processes in three spatial scales with a formation flight of up to 12 spacecraft, orbiting on deep elliptical orbits around Earth. One of the major challenges is the launch of that number of spacecraft on a single launcher and the collisionless deployment of the formation at the target orbit. The scope if the GeoSail TRS is to demonstrate deployment, attitude control and navigation concepts for a

  19. Cassini-Huygens Science Highlights: Surprises in the Saturn System

    Science.gov (United States)

    Spilker, Linda; Altobelli, Nicolas; Edgington, Scott

    2014-05-01

    The Cassini-Huygens mission has greatly enhanced our understanding of the Saturn system. Fundamental discoveries have altered our views of Saturn, its retinue of icy moons including Titan, the dynamic rings, and the system's complex magnetosphere. Launched in 1997, the Cassini-Huygens spacecraft spent seven years traveling to Saturn, arriving in July 2004, roughly two years after the northern winter solstice. Cassini has orbited Saturn for 9.5 years, delivering the Huygens probe to its Titan landing in 2005, crossing northern equinox in August 2009, and completing its Prime and Equinox Missions. It is now three years into its 7-year Solstice mission, returning science in a previously unobserved seasonal phase between equinox and solstice. As it watches the approach of northern summer, long-dark regions throughout the system become sunlit, allowing Cassini's science instruments to probe as-yet unsolved mysteries. Key Cassini-Huygens discoveries include icy jets of material streaming from tiny Enceladus' south pole, lakes of liquid hydrocarbons and methane rain on giant Titan, three-dimensional structures in Saturn's rings, and curtain-like aurorae flickering over Saturn's poles. The Huygens probe sent back amazing images of Titan's surface, and made detailed measurements of the atmospheric composition, structure and winds. Key Cassini-Huygens science highlights will be presented. The Solstice Mission continues to provide new science. First, the Cassini spacecraft observes seasonally and temporally dependent processes on Saturn, Titan, Enceladus and other icy satellites, and within the rings and magnetosphere. Second, it addresses new questions that have arisen during the mission thus far, for example providing qualitatively new measurements of Enceladus and Titan that could not be accommodated in the earlier mission phases. Third, it will conduct a close-in mission at Saturn yielding fundamental knowledge about the interior of Saturn. This grand finale of the

  20. Highlights of Odessa Branch of AN in 2017

    Science.gov (United States)

    Andronov, I. L.

    2017-12-01

    An annual report with a list of publications. Our group works on the variable star research within the international campaign "Inter-Longitude Astronomy" (ILA) based on temporarily working groups in collaboration with Poland, Slovakia, Korea, USA and other countries. A recent self-review on highlights was published in 2017. Our group continues the scientific school of Prof. Vladymir P. Tsesevich (1907 - 1983). Another project we participate is "AstroInformatics". The unprecedented photo-polarimetric monitoring of a group of AM Her - type magnetic cataclysmic variable stars was carried out since 1989 (photometry in our group - since 1978). A photometric monitoring of the intermediate polars (MU Cam, V1343 Her, V2306 Cyg et al.) was continued to study rotational evolution of magnetic white dwarfs. The super-low luminosity state was discovered in the outbursting intermediate polar = magnetic dwarf nova DO Dra. Previously typical low state was some times interrupted by outbursts, which are narrower than usual dwarf nova outbursts. Once there were detected TPO - "Transient Periodic Oscillations". The orbital and quasi-periodic variability was recently studied. Such super-low states are characteristic for nova-like variables (e.g. MV Lyr, TT Ari) or intermediate polars, but unusual for the dwarf novae. The electronic "Catalogue of Characteristics and Atlas of the Light Curves of Newly-Discovered Eclipsing Binary Stars" was compiled and is being prepared for publication. The software NAV ("New Algol Variable") with specially developed algorithms was used. It allows to determine the begin and end of the eclipses even in EB and EW - type stars, whereas the current classification (GCVS, VSX) claims that the begin and end of eclipses only in the EA - type objects. The further improvements of the NAV algorithm were comparatively studied. The "Wall-Supported Polynomial" (WSP) algoritms were implemented in the software MAVKA for statistically optimal modeling of flat eclipses

  1. Highlights 2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-02-15

    This document summarizes a year of activities for the ESRF (European synchrotron radiation facilities), this facility serves 31 beamlines that represent 34 end stations that can be run independently. This document is organized into 9 parts. Part 1: 'high resolution and resonance scattering' deals with surface science and magnetism at high pressure, in particular results are presented for samarium and europium chalcogenides. A cross-section of a variety of applications are presented, they range from glass physics to the understanding of thermoelectric materials. Part 2: 'materials sciences' deals with material behaviour under extreme conditions (metallic sulfur above 100 GPa,...) general applications of X-ray diffraction : stress and strain studies, assessment of excess free volume in metallic glasses, or grain nucleation and growth kinetics during solidification. Part 3: 'soft condensed matter'. Part 4: 'structural biology'. Part 5: 'surface and interface science' (at ESRF surfaces and interfaces are studied at about 50% of all beamlines). A study shows the existence of ordered SiGe domains in the interior of the small Ge islands in Si, whereas bulk SiGe alloy is disordered. Other studies shed light on the surprisingly different magnetic behaviour of ultra-thin cobalt and nickel films on a platinum surface. Part 6 : 'X-ray absorption and magnetic scattering'. Many of the studies push the limits of methods using high pressure, high magnetic fields, high and low temperature with absorption and scattering techniques. There are also examples of measurements on the femtosecond time scale using the core-hole clock method and on femto-meter length scale in magnetostriction measurements. Part 7: 'X-ray imaging and optics'. Part 8: 'the X-ray source'. Part 9: 'facts and figures'. (A.C.)

  2. Brookhaven highlights

    Energy Technology Data Exchange (ETDEWEB)

    Rowe, M.S.; Cohen, A.; Greenberg, D.; Seubert, L. (eds.)

    1992-01-01

    This publication provides a broad overview of the research programs and efforts being conducted, built, designed, and planned at Brookhaven National Laboratory. This work covers a broad range of scientific disciplines. Major facilities include the Alternating Gradient Synchrotron (AGS), with its newly completed booster, the National Synchrotron Light Source (NSLS), the High Flux Beam Reactor (HFBR), and the RHIC, which is under construction. Departments within the laboratory include the AGS department, accelerator development, physics, chemistry, biology, NSLS, medical, nuclear energy, and interdepartmental research efforts. Research ranges from the pure sciences, in nuclear physics and high energy physics as one example, to environmental work in applied science to study climatic effects, from efforts in biology which are a component of the human genome project to the study, production, and characterization of new materials. The paper provides an overview of the laboratory operations during 1992, including staffing, research, honors, funding, and general laboratory plans for the future.

  3. 1982 Highlights

    International Nuclear Information System (INIS)

    Anon.

    1983-01-01

    A short report of the activities of the Brazilian Energy and Mines Ministery - MME -, is presented, emphasizing the most important facts that happened in its several areas of actuation during 1982. Through a simple and objective communication, those facts are shown. (E.G.) [pt

  4. Brookhaven highlights

    International Nuclear Information System (INIS)

    Rowe, M.S.; Cohen, A.; Greenberg, D.; Seubert, L.

    1992-01-01

    This publication provides a broad overview of the research programs and efforts being conducted, built, designed, and planned at Brookhaven National Laboratory. This work covers a broad range of scientific disciplines. Major facilities include the Alternating Gradient Synchrotron (AGS), with its newly completed booster, the National Synchrotron Light Source (NSLS), the High Flux Beam Reactor (HFBR), and the RHIC, which is under construction. Departments within the laboratory include the AGS department, accelerator development, physics, chemistry, biology, NSLS, medical, nuclear energy, and interdepartmental research efforts. Research ranges from the pure sciences, in nuclear physics and high energy physics as one example, to environmental work in applied science to study climatic effects, from efforts in biology which are a component of the human genome project to the study, production, and characterization of new materials. The paper provides an overview of the laboratory operations during 1992, including staffing, research, honors, funding, and general laboratory plans for the future

  5. Austrian highlights

    International Nuclear Information System (INIS)

    Jones, Simon

    2001-01-01

    An overview of recent development in the Austrian hydroelectric industry is presented, and details of the installed capacity, the Austrian government's power market reform package, and the promotion of small-scale hydroelectric power plants are given. The operation of Verbund - Austria's largest power generator and distributor - and the restructuring of the Verbund's main Austrian Hydro Power (AHP) generating group are discussed. The export of power, the joint venture of Verbund with CIR Energia in Italy to market power to commercial and industrial users, and the controversy surrounding the Freudenau run-of-the river plant which successfully tested a matrix turbine are reported

  6. 2013 Highlights

    International Nuclear Information System (INIS)

    2014-01-01

    The annual report gives a summary overview of key research and development activities at the Belgian Nuclear Research Centre SCK-CEN in 2013. The report discusses progress and main achievements in the following areas: reactor safety, radioactive waste and decommissioing, radiation protection, the BR2 reactor, nuclear fuel research, raduioactivity and the environment and medical applications with emphasis on dosimetry.

  7. Highlights 2005

    International Nuclear Information System (INIS)

    2006-02-01

    This document summarizes a year of activities for the ESRF (European synchrotron radiation facilities), this facility serves 31 beamlines that represent 34 end stations that can be run independently. This document is organized into 9 parts. Part 1: 'high resolution and resonance scattering' deals with surface science and magnetism at high pressure, in particular results are presented for samarium and europium chalcogenides. A cross-section of a variety of applications are presented, they range from glass physics to the understanding of thermoelectric materials. Part 2: 'materials sciences' deals with material behaviour under extreme conditions (metallic sulfur above 100 GPa,...) general applications of X-ray diffraction : stress and strain studies, assessment of excess free volume in metallic glasses, or grain nucleation and growth kinetics during solidification. Part 3: 'soft condensed matter'. Part 4: 'structural biology'. Part 5: 'surface and interface science' (at ESRF surfaces and interfaces are studied at about 50% of all beamlines). A study shows the existence of ordered SiGe domains in the interior of the small Ge islands in Si, whereas bulk SiGe alloy is disordered. Other studies shed light on the surprisingly different magnetic behaviour of ultra-thin cobalt and nickel films on a platinum surface. Part 6 : 'X-ray absorption and magnetic scattering'. Many of the studies push the limits of methods using high pressure, high magnetic fields, high and low temperature with absorption and scattering techniques. There are also examples of measurements on the femtosecond time scale using the core-hole clock method and on femto-meter length scale in magnetostriction measurements. Part 7: 'X-ray imaging and optics'. Part 8: 'the X-ray source'. Part 9: 'facts and figures'. (A.C.)

  8. Highlights 2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-02-15

    This document summarizes a year of activities for the ESRF (European synchrotron radiation facilities), this facility serves 31 beamlines that represent 34 end stations that can be run independently. This document is organized into 9 parts. Part 1: 'high resolution and resonance scattering' deals with surface science and magnetism at high pressure, in particular results are presented for samarium and europium chalcogenides. A cross-section of a variety of applications are presented, they range from glass physics to the understanding of thermoelectric materials. Part 2: 'materials sciences' deals with material behaviour under extreme conditions (metallic sulfur above 100 GPa,...) general applications of X-ray diffraction : stress and strain studies, assessment of excess free volume in metallic glasses, or grain nucleation and growth kinetics during solidification. Part 3: 'soft condensed matter'. Part 4: 'structural biology'. Part 5: 'surface and interface science' (at ESRF surfaces and interfaces are studied at about 50% of all beamlines). A study shows the existence of ordered SiGe domains in the interior of the small Ge islands in Si, whereas bulk SiGe alloy is disordered. Other studies shed light on the surprisingly different magnetic behaviour of ultra-thin cobalt and nickel films on a platinum surface. Part 6 : 'X-ray absorption and magnetic scattering'. Many of the studies push the limits of methods using high pressure, high magnetic fields, high and low temperature with absorption and scattering techniques. There are also examples of measurements on the femtosecond time scale using the core-hole clock method and on femto-meter length scale in magnetostriction measurements. Part 7: 'X-ray imaging and optics'. Part 8: 'the X-ray source'. Part 9: 'facts and figures'. (A.C.)

  9. 2014 Highlights

    International Nuclear Information System (INIS)

    2015-01-01

    The annual report gives a summary overview of key research and development activities at the Belgian Nuclear Research Centre SCK-CEN in 2014. The report discusses progress and main achievements in the following areas: reactor safety, radioactive waste and decommissioning, radiation protection, the BR2 reactor, nuclear fuel research, radioactivity and the environment and medical applications with emphasis on dosimetry.

  10. HAWC highlights

    Energy Technology Data Exchange (ETDEWEB)

    Jardin-Blicq, Armelle [Max Planck Institut fuer Kernphysik (Germany); Collaboration: HAWC-Collaboration

    2016-07-01

    The High-Altitude Water Cherenkov (HAWC) Observatory was completed and began full operation on March 20, 2015. The detector consists of an array of 300 water tanks, each containing 200 tons of purified water and instrumented with 4 PMTs. Located at an elevation of 4100m a.s.l. near the Sierra Negra volcano in central Mexico, HAWC observes gamma rays in the 0.1-100 TeV range and has a sensitivity to TeV-scale gamma-ray sources an order of magnitude better than previous air-shower arrays. It has 2 sr field-of-view and >90% duty cycle make HAWC an ideal instrument for surveying the high-energy sky. We describe the HAWC detector and its performance characteristics and report initial results from the first months of operation.

  11. MAGIC highlights

    Directory of Open Access Journals (Sweden)

    López-Coto Rubén

    2016-01-01

    Full Text Available The present generation of Imaging Air Cherenkov Telescopes (IACTs has greatly improved our knowledge on the Very High Energy (VHE side of our Universe. The MAGIC IACTs operate since 2004 with one telescope and since 2009 as a two telescope stereoscopic system. I will outline a few of our latest and most relevant results: the discovery of pulsed emission from the Crab pulsar at VHE, recently found to extend up to 400 GeV and along the “bridge” of the light curve, the measurement of the Crab nebula spectrum over three decades of energy, the discovery of VHE γ-ray emission from the PWN 3C 58, the very rapid emission of IC 310, in addition to dark matter studies. The results that will be described here and the planned deep observations in the next years will pave the path for the future generation of IACTs.

  12. Modeling sports highlights using a time-series clustering framework and model interpretation

    Science.gov (United States)

    Radhakrishnan, Regunathan; Otsuka, Isao; Xiong, Ziyou; Divakaran, Ajay

    2005-01-01

    In our past work on sports highlights extraction, we have shown the utility of detecting audience reaction using an audio classification framework. The audio classes in the framework were chosen based on intuition. In this paper, we present a systematic way of identifying the key audio classes for sports highlights extraction using a time series clustering framework. We treat the low-level audio features as a time series and model the highlight segments as "unusual" events in a background of an "usual" process. The set of audio classes to characterize the sports domain is then identified by analyzing the consistent patterns in each of the clusters output from the time series clustering framework. The distribution of features from the training data so obtained for each of the key audio classes, is parameterized by a Minimum Description Length Gaussian Mixture Model (MDL-GMM). We also interpret the meaning of each of the mixture components of the MDL-GMM for the key audio class (the "highlight" class) that is correlated with highlight moments. Our results show that the "highlight" class is a mixture of audience cheering and commentator's excited speech. Furthermore, we show that the precision-recall performance for highlights extraction based on this "highlight" class is better than that of our previous approach which uses only audience cheering as the key highlight class.

  13. Highlighting the gap between critical outcomes requirements and built environment education in South Africa

    CSIR Research Space (South Africa)

    Ampofo-Anti, NL

    2007-06-01

    Full Text Available This paper aims to highlight the discrepancies between current built environment education and Critical Outcomes requirements of the South African National Qualifications Framework (NQF)...

  14. Highlights Eurosites insights; highlights on image, implementation, interpretation and integration of Natura 2000 in European perspective; United Kingdom, Sweden, Spain, France and Hungary

    NARCIS (Netherlands)

    Neven, M.G.G.; Kistenkas, F.H.

    2005-01-01

    Highlighting the main report Eurosites Insights this comparative study analyses Natura 2000 nature conservation (EU Birds- and Habitats Directives) alongside the key issues of image, implementation, interpretation and integration. Having quick scanned the EU25, five member states have been selected

  15. Moving beyond Text Highlights: Inferring Users' Interests to Improve the Relevance of Retrieval

    Science.gov (United States)

    Balakrishnan, Vimala; Mehmood, Yasir; Nagappan, Yoganathan

    2016-01-01

    Introduction: Studies have indicated that users' text highlighting behaviour can be further manipulated to improve the relevance of retrieved results. This article reports on a study that examined users' text highlight frequency, length and users' copy-paste actions. Method: A binary voting mechanism was employed to determine the weights for the…

  16. North-American Conference Highlights the Treatment of Trauma Utilizing Guided Imagery and Music

    DEFF Research Database (Denmark)

    Scott-Montcrieff, Suzannah; Beck, Bolette Daniels; Montgomery, Erin

    2015-01-01

    A report on the 2015 Association for Music and Imagery conference highlights papers that address clinical practice and research using Guided Imagery and Music for the treatment of trauma.......A report on the 2015 Association for Music and Imagery conference highlights papers that address clinical practice and research using Guided Imagery and Music for the treatment of trauma....

  17. Tourette syndrome research highlights from 2016 [version 2; referees: 4 approved

    Directory of Open Access Journals (Sweden)

    Kevin J. Black

    2017-11-01

    Full Text Available This article presents highlights chosen from research that appeared during 2016 on Tourette syndrome and other tic disorders. Selected articles felt to represent meaningful advances in the field are briefly summarized.

  18. Tourette syndrome research highlights from 2016 [version 1; referees: 2 approved, 1 approved with reservations

    Directory of Open Access Journals (Sweden)

    Kevin J. Black

    2017-08-01

    Full Text Available This article presents highlights chosen from research that appeared during 2016 on Tourette syndrome and other tic disorders. Selected articles felt to represent meaningful advances in the field are briefly summarized.

  19. January 1978 monthly highlights for Office of Nuclear Regulatory Research Programs at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Mynatt, F.R.

    1978-01-01

    Highlights of technical progress during January 1978 are presented for sixteen separate program activities which comprise the ORNL research program for the Office of Nuclear Regulatory Research's Division of Reactor Safety Research

  20. PNNL Highlights for the Office of Basic Energy Sciences (July 2013-July 2014)

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Benjamin; Warren, Pamela M.; Manke, Kristin L.

    2014-08-13

    This report includes research highlights of work funded in part or whole by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences as well as selected leadership accomplishments.

  1. The Third International Congress on Child Abuse and Neglect: Conference Highlights.

    Science.gov (United States)

    Besharov, Douglas J.

    1981-01-01

    Presents highlights from the Third International Congress on Child Abuse and Neglect. The topic of child sexual abuse dominated the Congress; other topics included malnutrition, research problems, and concerns of Third World countries. Recommendations of the Congress are summarized.

  2. Symposium on Highlights from 14 years of LEAR Physics : "LEAR Performance" by M. Chanel

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields: M. Chanel "LEAR Performance"

  3. Symposium on Highlights from 14 years of LEAR Physics : "Atomic Physics" by E. Uggerhoj

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  4. Symposium on Highlights from 14 years of LEAR Physics : "Antiproton Mass" by G. Gabrielse

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  5. Symposium on Highlights from 14 years of LEAR Physics : "CP Violation" by P. Pavlopoulos

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  6. Symposium on Highlights from 14 years of LEAR Physics : "AD Project" by S. Maury

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields: S. Maury "AD Project"

  7. Symposium on Highlights from 14 years of LEAR Physics: "Light Antiprotonic Atoms" by R. Hayano

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  8. Symposium on Highlights from 14 years of LEAR Physics : R. Landua (chairman)

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  9. Symposium on Highlights from 14 years of LEAR Physics : "Nuclear Physics" by T. von Egidy

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 145 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  10. Symposium on Highlights from 14 years of LEAR Physics : "Meson spectroscopy" by H. Koch

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  11. Symposium on Highlights from 14 years of LEAR Physics : "Annihilation at Rest" by U. Gastaldi

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  12. Symposium on Highlights from 14 years of LEAR Physics : "Annihilation in Flight" by D. Hertzog

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  13. Monthly highlights for Office of Nuclear Regulatory Research Programs at Oak Ridge National Laboratory, March 1977

    International Nuclear Information System (INIS)

    Fee, G.G.

    1977-01-01

    Highlights of technical progress during March 1977 are presented for thirteen separate program activities which comprise the ORNL research program for the Office of Nuclear Regulatory Research's Division of Reactor Safety Research

  14. Highlight: Private sector could play a major role in feeding Africa ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2014-09-08

    Sep 8, 2014 ... Highlight: Private sector could play a major role in feeding Africa ... scale, we will need to involve the private sector," said IDRC President Jean Lebel. ... There is ample evidence that addressing gender inequalities and ...

  15. Highlight shapes and perception of gloss for real and photographed objects.

    Science.gov (United States)

    van Assen, Jan Jaap R; Wijntjes, Maarten W A; Pont, Sylvia C

    2016-01-01

    Gloss perception strongly depends on the three-dimensional shape and the illumination of the object under consideration. In this study we investigated the influence of the spatial structure of the illumination on gloss perception. A diffuse light box in combination with differently shaped masks was used to produce a set of six simple and complex highlight shapes. The geometry of the simple highlight shapes was inspired by conventional artistic practice (e.g., ring flash for photography, window shape for painting and disk or square for cartoons). In the box we placed spherical stimuli that were painted in six degrees of glossiness. This resulted in a stimulus set of six highlight shapes and six gloss levels, a total of 36 stimuli. We performed three experiments of which two took place using digital photographs on a computer monitor and one with the real spheres in the light box. The observers had to perform a comparison task in which they chose which of two stimuli was glossiest and a rating task in which they rated the glossiness. The results show that, perhaps surprisingly, more complex highlight shapes were perceived to produce a less glossy appearance than simple highlight shapes such as a disk or square. These findings were confirmed for both viewing conditions, on a computer display and in a real setting. The results show that variations in the spatial structure of "rather simple" illumination of the "extended source" type highlight influences perceived glossiness.

  16. Chlorophyll b degradation by chlorophyll b reductase under high-light conditions.

    Science.gov (United States)

    Sato, Rei; Ito, Hisashi; Tanaka, Ayumi

    2015-12-01

    The light-harvesting chlorophyll a/b binding protein complex of photosystem II (LHCII) is the main antenna complex of photosystem II (PSII). Plants change their LHCII content depending on the light environment. Under high-light conditions, the content of LHCII should decrease because over-excitation damages the photosystem. Chlorophyll b is indispensable for accumulating LHCII, and chlorophyll b degradation induces LHCII degradation. Chlorophyll b degradation is initiated by chlorophyll b reductase (CBR). In land plants, NON-YELLOW COLORING 1 (NYC1) and NYC1-Like (NOL) are isozymes of CBR. We analyzed these mutants to determine their functions under high-light conditions. During high-light treatment, the chlorophyll a/b ratio was stable in the wild-type (WT) and nol plants, and the LHCII content decreased in WT plants. The chlorophyll a/b ratio decreased in the nyc1 and nyc1/nol plants, and a substantial degree of LHCII was retained in nyc1/nol plants after the high-light treatment. These results demonstrate that NYC1 degrades the chlorophyll b on LHCII under high-light conditions, thus decreasing the LHCII content. After the high-light treatment, the maximum quantum efficiency of the PSII photochemistry was lower in nyc1 and nyc1/nol plants than in WT and nol plants. A larger light-harvesting system would damage PSII in nyc1 and nyc1/nol plants. The fluorescence spectroscopy of the leaves indicated that photosystem I was also damaged by the excess LHCII in nyc1/nol plants. These observations suggest that chlorophyll b degradation by NYC1 is the initial reaction for the optimization of the light-harvesting capacity under high-light conditions.

  17. Institutional supporting research highlights in physics and mathematics, fiscal year 1983

    International Nuclear Information System (INIS)

    Vigil, J.C.

    1984-03-01

    Highlights of FY 1983 Institutional Supporting Research and Development activities within the six Physics and Mathematics divisions and the Center for Nonlinear Studies are presented. The highlights are but a fraction of the ISRD activities in the Directorate and are intended to be a representative sample of progress in the various research areas. FY 1983 ISRD activities within the Physics and Mathematics divisions included both basic and applied research and were divided into 11 research areas: mathematics and numerical methods, low-energy nuclear physics, medium- and high-energy nuclear physics, atomic and molecular physics, solid-state physics and materials science, fluid dynamics, plasma physics and intense particle beam theory, astrophysics and space physics, particle transport methods, accelerator and fusion technology, and biophysics. Highlights from each of these areas are presented

  18. A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility

    DEFF Research Database (Denmark)

    Damotte, V; Guillot-Noel, L; Patsopoulos, N A

    2014-01-01

    adhesion molecule (CAMs) biological pathway using Cytoscape software. This network is a strong candidate, as it is involved in the crossing of the blood-brain barrier by the T cells, an early event in MS pathophysiology, and is used as an efficient therapeutic target. We drew up a list of 76 genes...... in interaction with other genes as a group. Pathway analysis is an alternative way to highlight such group of genes. Using SNP association P-values from eight multiple sclerosis (MS) GWAS data sets, we performed a candidate pathway analysis for MS susceptibility by considering genes interacting in the cell...... belonging to the CAM network. We highlighted 64 networks enriched with CAM genes with low P-values. Filtering by a percentage of CAM genes up to 50% and rejecting enriched signals mainly driven by transcription factors, we highlighted five networks associated with MS susceptibility. One of them, constituted...

  19. Highlighted scientific findings of the Interior Columbia Basin Ecosystem Management Project.

    Science.gov (United States)

    Thomas M. Quigley; Heidi. Bigler Cole

    1997-01-01

    Decisions regarding 72 million acres of Forest Service- and Bureau of Land Management- administered lands will be based on scientific findings brought forth in the Interior Columbia Basin Ecosystem Management Project. Some highlights of the scientific findings are presented here. Project scientists drew three general conclusions: (1) Conditions and trends differ widely...

  20. Ethical Challenges in a Complex World: Highlights of the 2005 ACA Code of Ethics

    Science.gov (United States)

    Kocet, Michael M.

    2006-01-01

    Being an effective counselor includes having knowledge of and the ability to integrate a code of ethics into one's professional practice. This article addresses some of the highlights of the changes in the 2005 ACA [American Counseling Association] Code of Ethics such as end-of-life issues, boundaries and relationships, and multicultural and…

  1. Three decades of Cognition & Emotion : A brief review of past highlights and future prospects

    NARCIS (Netherlands)

    Rothermund, Klaus; Koole, Sander L.

    Over the past three decades, Cognition & Emotion has been one of the world’s leading outlets for emotion research. In this article, we review past highlights of and future prospects for the journal. Our tour of history covers three periods: The first period, from 1987 to 1999, was a pioneering era

  2. The Effects of Highlight Color on Immediate Recall on Subjects of Different Cognitive Styles.

    Science.gov (United States)

    Worley, Gary M.; Moore, David M.

    2001-01-01

    Discussion of the use of color for enhancing recognition memory focuses on a study of undergraduates that evaluated images as black and white, full color, or highlight color and the effect these characteristics had on recognition memory and recall for learners classified as field-dependent and field-independent in terms of cognitive style. (LRW)

  3. A deep learning approach for detecting and correcting highlights in endoscopic images

    NARCIS (Netherlands)

    Rodriguez-Sanchez, Antonio; Chea, Daly; Azzopardi, George; Stabinger, Sebastian

    2017-01-01

    The image of an object changes dramatically depending on the lightning conditions surrounding that object. Shadows, reflections and highlights can make the object very difficult to be recognized for an automatic system. Additionally, images used in medical applications, such as endoscopic images and

  4. The Probability Evaluation Game: An Instrument to Highlight the Skill of Reflexive Listening

    Science.gov (United States)

    Butler, Clare

    2016-01-01

    This paper describes the development of the Probability Evaluation Game (PEG): an innovative teaching instrument that emphasises the sophistication of listening and highlights listening as a key skill for accounting practitioners. Whilst in a roundtable format, playing PEG involves participants individually evaluating a series of probability terms…

  5. State Digital Learning Exemplars: Highlights from States Leading Change through Policies and Funding

    Science.gov (United States)

    Acree, Lauren; Fox, Christine

    2015-01-01

    States are striving to support the expansion of technology tools and resources in K-12 education through state policies, programs, and funding in order to provide digital learning opportunities for all students. This paper highlights examples of states with policies in support of five key areas: (1) innovative funding streams and policy; (2)…

  6. Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes

    DEFF Research Database (Denmark)

    de Jong, Simone; van Eijk, Kristel R; Zeegers, Dave W L H

    2012-01-01

    of the Psychiatric GWAS consortium (PGC) yielded five novel loci for schizophrenia. In this study, we aim to highlight additional schizophrenia susceptibility loci from the PGC study by combining the top association findings from the discovery stage (9394 schizophrenia cases and 12 462 controls) with expression QTLs...

  7. Water Reuse Highlights: A Summary Volume of Wastewater Reclamation and Reuse Information.

    Science.gov (United States)

    American Water Works Association, Denver, CO. Research Foundation.

    This document reports the efforts of the AWWA Research Foundation to gather, prepare, and distribute current technical information in the wastewater reclamation and reuse field. The information reported has been abstracted from other Foundation publications and only attempts here to highlight the field. Categories discussed include research,…

  8. The Water Quality in Rio Highlights the Global Public Health Concern Over Untreated Sewage Disposal

    Science.gov (United States)

    Water quality issues in Rio have been widely publicized because of the 2016 Olympics. Recent concerns about polluted waters that athletes may be exposed to highlights the conditions that more than a billion people globally are exposed to daily. Despite these unhealthy conditions,...

  9. Aeroacoustics research in Europe : the CEAS-ASC report on 1997 highlights

    NARCIS (Netherlands)

    Rienstra, S.W.

    1998-01-01

    This paper is a report on the highlights of aeroacoustics research and development in Europe in 1997, compiled from information provided in the CEAS Aeroacoustics Specialists Committee (ASC). The Confederation of European Aerospace Societies (CEAS) comprises the national Aerospace Societies of

  10. Highlights of papers presented at the workshop on cold fusion phenomena

    International Nuclear Information System (INIS)

    1989-09-01

    This report contains highlights of formal oral papers presented at the Workshop on Cold Fusion Phenomena, hosted by Los Alamos National Laboratory and held May 23--25, 1989, in Santa Fe, New Mexico. General topics covered are: physics of fusion reactions; neutron and gamma-ray spectroscopy; colorimetry; and applicable condensed-matter physics, electrochemistry, and analytical chemistry

  11. The Contribution of Text-Highlighting to Comprehension: A Comparison of Print and Digital Reading

    Science.gov (United States)

    Ben-Yehudah, Gal; Eshet-Alkalai, Yoram

    2018-01-01

    The use of digital materials in educational settings is common, despite evidence indicating that comprehension of digital text is inferior to comprehension of printed text. A potential solution to this problem is to use learning strategies for deeper text processing. Text-highlighting is a strategy known to improve comprehension of printed text;…

  12. Highlighting the Transfer, Honors, and Excellence Workshop. CSCC Bulletin, Issue 7, 1983.

    Science.gov (United States)

    Center for the Study of Community Colleges, Los Angeles, CA.

    Summaries are provided for the major presentations given at a workshop on honors, transfer, and excellence, held in Los Angeles in October 1982. Following a brief overview of the main topics covered, highlights are presented from the talks of: (1) Robert McCabe, president of Miami-Dade Community College (MDCC), who urged participants to set high…

  13. Frontiers: Research highlights 1946-1996 [50th Anniversary Edition. Argonne National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    This special edition of 'Frontiers' commemorates Argonne National Laboratory's 50th anniversary of service to science and society. America's first national laboratory, Argonne has been in the forefront of U.S. scientific and technological research from its beginning. Past accomplishments, current research, and future plans are highlighted.

  14. Macro Photography for Reflectance Transformation Imaging: A Practical Guide to the Highlights Method

    Directory of Open Access Journals (Sweden)

    Antonino Cosentino

    2014-11-01

    Full Text Available Reflectance Transformation Imaging (RTI is increasingly being used for art documentation and analysis and it can be successful also for the examination of features on the order of hundreds of microns. This paper evaluates some macro scale photography methods specifically for RTI employing the Highlights method for documenting sub-millimeter details. This RTI technique consists in including one reflective sphere in the scene photographed so that the processing software can calculate for each photo the direction of the light source from its reflection on the sphere. RTI documentation can be performed also with an RTI dome, but the Highlights method is preferred because is more mobile and more affordable. This technique is demonstrated in the documentation of some prints ranging from the XV to the XX century from to the Ingels collection in Sweden. The images are here examined and discussed, showing the application of macro RTI for identifying features of prints.

  15. Highlights from the SOAP project survey. What Scientists Think about Open Access Publishing

    CERN Document Server

    Dallmeier-Tiessen, Suenje; Goerner, Bettina; Hyppoelae, Jenni; Igo-Kemenes, Peter; Kahn, Deborah; Lambert, Simon; Lengenfelder, Anja; Leonard, Chris; Mele, Salvatore; Nowicka, Malgorzata; Polydoratou, Panayiota; Ross, David; Ruiz-Perez, Sergio; Schimmer, Ralf; Swaisland, Mark; van der Stelt, Wim

    2011-01-01

    The SOAP (Study of Open Access Publishing) project has run a large-scale survey of the attitudes of researchers on, and the experiences with, open access publishing. Around forty thousands answers were collected across disciplines and around the world, showing an overwhelming support for the idea of open access, while highlighting funding and (perceived) quality as the main barriers to publishing in open access journals. This article serves as an introduction to the survey and presents this and other highlights from a preliminary analysis of the survey responses. To allow a maximal re-use of the information collected by this survey, the data are hereby released under a CC0 waiver, so to allow libraries, publishers, funding agencies and academics to further analyse risks and opportunities, drivers and barriers, in the transition to open access publishing.

  16. Monthly highlights for Office of Nuclear Regulatory Research Programs at Oak Ridge National Laboratory, August 1977

    International Nuclear Information System (INIS)

    Fee, G.G.

    1977-01-01

    Technical highlights are presented for the following safety-related studies: heavy section steel technology, fission product beta and gamma energy release, fission product release from LWR fuel, fission product transport tests, multirod burst tests, Nuclear Safety Information Center, PWR blowdown heat transfer-separate effects, zircaloy fuel cladding collapse studies, zirconium metal-water oxidation kinetics, aerosol release and transport from LMFBR fuel, HTGR safety analysis and research, design criteria for piping and nozzles, and noise diagnostics for safety assessment

  17. Women's expectations and experiences of maternity care in NSW--what women highlight as most important.

    Science.gov (United States)

    Jenkins, Mary G; Ford, Jane B; Morris, Jonathan M; Roberts, Christine L

    2014-09-01

    Although surveys have identified that women are generally highly satisfied with maternity care provision, those aspects of care that women highlight as most important for achieving satisfaction and a satisfactory maternity care experience have not been reported. The aim of this study was to investigate how women understand and experience their maternity care and to report which aspects of care women highlight as most important. This large qualitative study explored women's expectations and experiences of maternity care provision. In-depth semi-structured interviews were conducted with 53 women experiencing maternity care in a range of tertiary, regional, rural, remote hospitals and midwife-led practices in the state of New South Wales, Australia during 2011-2012. Included in the interview schedule was the question 'What 3 aspects would you see as most important for delivery of maternity care?' Descriptive analyses of entire transcripts and responses to the question on most important aspects of care were undertaken. Descriptive analyses of women's responses identified 5 important aspects of care: woman-focused care, staff qualities, systems and facilities, family-focused care and continuity of care/information. First-time mothers were more likely to identify woman-focused care, staff qualities and continuity of care/information as important aspects than multiparous mothers. Urban and regional mothers highlighted staff qualities as having greater importance for satisfaction with their care while rural and particularly remote women nominated systems and facilities as important. Our study showed that women from a range of settings are more concerned with staff and relational issues than facilities. Differences in perceptions among primiparous versus multiparous women, at different stages of pregnancy and among women from rural and remote compared to urban settings highlight the need to include women with a diversity of experience when trying to understand the aspects

  18. Brookhaven highlights for fiscal year 1991, October 1, 1990--September 30, 1991

    International Nuclear Information System (INIS)

    Rowe, M.S.; Cohen, A.; Greenberg, D.; Seubert, L.; Kuper, J.B.H.

    1991-01-01

    This report highlights Brookhaven National Laboratory's activities for fiscal year 1991. Topics from the four research divisions: Computing and Communications, Instrumentation, Reactors, and Safety and Environmental Protection are presented. The research programs at Brookhaven are diverse, as is reflected by the nine different scientific departments: Accelerator Development, Alternating Gradient Synchrotron, Applied Science, Biology, Chemistry, Medical, National Synchrotron Light Source, Nuclear Energy, and Physics. Administrative and managerial information about Brookhaven are also disclosed

  19. Brookhaven highlights. Report on research, October 1, 1992--September 30, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Rowe, M.S.; Belford, M.; Cohen, A.; Greenberg, D.; Seubert, L. [eds.

    1993-12-31

    This report highlights the research activities of Brookhaven National Laboratory during the period dating from October 1, 1992 through September 30, 1993. There are contributions to the report from different programs and departments within the laboratory. These include technology transfer, RHIC, Alternating Gradient Synchrotron, physics, biology, national synchrotron light source, applied science, medical science, advanced technology, chemistry, reactor physics, safety and environmental protection, instrumentation, and computing and communications.

  20. Brookhaven highlights for fiscal year 1991, October 1, 1990--September 30, 1991

    Energy Technology Data Exchange (ETDEWEB)

    Rowe, M.S.; Cohen, A.; Greenberg, D.; Seubert, L.; Kuper, J.B.H.

    1991-01-01

    This report highlights Brookhaven National Laboratory's activities for fiscal year 1991. Topics from the four research divisions: Computing and Communications, Instrumentation, Reactors, and Safety and Environmental Protection are presented. The research programs at Brookhaven are diverse, as is reflected by the nine different scientific departments: Accelerator Development, Alternating Gradient Synchrotron, Applied Science, Biology, Chemistry, Medical, National Synchrotron Light Source, Nuclear Energy, and Physics. Administrative and managerial information about Brookhaven are also disclosed. (GHH)

  1. Brookhaven highlights for fiscal year 1991, October 1, 1990--September 30, 1991

    Energy Technology Data Exchange (ETDEWEB)

    Rowe, M.S.; Cohen, A.; Greenberg, D.; Seubert, L.; Kuper, J.B.H.

    1991-12-31

    This report highlights Brookhaven National Laboratory`s activities for fiscal year 1991. Topics from the four research divisions: Computing and Communications, Instrumentation, Reactors, and Safety and Environmental Protection are presented. The research programs at Brookhaven are diverse, as is reflected by the nine different scientific departments: Accelerator Development, Alternating Gradient Synchrotron, Applied Science, Biology, Chemistry, Medical, National Synchrotron Light Source, Nuclear Energy, and Physics. Administrative and managerial information about Brookhaven are also disclosed. (GHH)

  2. Monthly highlights for Office of Nuclear Regulatory Research Programs at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Fee, G.G.

    1976-08-01

    Brief highlights are presented for the following programs: heavy section steel technology, fission product beta and gamma energy release, LOCA release from LWR fuel, multirod burst tests, Nuclear Safety Information Center, PWR blowdown heat transfer-separate effects, zircaloy fuel cladding collapse studies, zirconium metal-water oxidation kinetics, aerosol release and transport from LMFBR fuel, HTGR safety analysis, design criteria for piping and nozzles, and dose conversion factors for inhalation of radionuclides

  3. Highlighting Energy Policies and Strategies for the Residential Sector in Malaysia

    OpenAIRE

    Bekhet, Hussain Ali; Ivy-Yap, Lee Lian

    2014-01-01

    Energy is an important catalyst for development. Malaysia is very fortunate to be endowed with oil reserves. However, these reserves are finite and not renewable. Being cognizant of this, the Malaysian government had implemented various energy policies and strategies to manage and safeguard its oil reserves for better energy security as well as to promote prudent use of energy. This paper aims to highlight the electricity sector in Malaysia and the various policies and strategies implemented ...

  4. Monthly highlights for Office of Nuclear Regulatory research programs at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Fee, G.G.

    1975-04-01

    Summaries are given of the following programs: heavy section steel technology, fission product beta and gamma energy release, LOCA release from LWR fuel, multirod burst tests, Nuclear Safety Information Center, PWR blowdown heat transfer--separate effects, Zircaloy fuel cladding collapse studies, Zr metal--water oxidation kinetics, transient vaporization of LMFBR fuel, and HTGR safety analysis and research. Technical highlights and cost/budget reports are included. (U.S.)

  5. Monthly highlights for Office of Nuclear Regulatory Research Programs at Oak Ridge National Laboratory, August 1976

    International Nuclear Information System (INIS)

    Fee, G.G.

    1976-10-01

    Technical highlights are presented for the following activities: heavy section steel technology, fission product beta and gamma energy release, LOCA release from LWR fuel, Nuclear Safety Information Center, PWR blowdown heat transfer-separate effects, Zircaloy fuel cladding collapse studies, zirconium metal-water oxidation kinetics, aerosol release and transport from LMFBR fuel, HTGR safety analysis and research, design criteria for piping and nozzles, and dose conversion factors for inhalation of radionuclides

  6. Highlights of the 16th annual scientific sessions of the Society for Cardiovascular Magnetic Resonance.

    Science.gov (United States)

    Carpenter, John-Paul; Patel, Amit R; Fernandes, Juliano Lara

    2013-07-19

    The 16th Annual Scientific Sessions of the Society for Cardiovascular Magnetic Resonance (SCMR) took place in San Francisco, USA at the end of January 2013. With a faculty of experts from across the world, this congress provided a wealth of insight into cutting-edge research and technological development. This review article intends to provide a highlight of what represented the most significant advances in the field of cardiovascular magnetic resonance (CMR) during this year's meeting.

  7. Monthly highlights for Office of Nuclear Regulatory Research Programs at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Fee, G.G.

    1976-02-01

    Brief highlights are presented for the following activities: heavy section steel technology program, fission product β and γ energy release, LOCA release from LWR fuel, multirod burst tests, Nuclear Safety Information Center, PWR blowdown heat transfer-separate effects, zircaloy fuel cladding collapse studies, zirconium metal-water oxidation kinetics, aerosol release and transport from LMFBR fuel, HTGR safety analysis and research, and design criteria for piping and nozzles

  8. Adaptive highlights stencils for modeling of multi-axial BRDF anisotropy

    Czech Academy of Sciences Publication Activity Database

    Filip, Jiří; Havlíček, Michal; Vávra, Radomír

    2017-01-01

    Roč. 33, č. 1 (2017), s. 5-15 ISSN 0178-2789 R&D Projects: GA ČR(CZ) GA14-02652S Institutional support: RVO:67985556 Keywords : anisotropic * Highlight * stencils * BRDF * model Subject RIV: BD - Theory of Information OBOR OECD: Applied mathematics Impact factor: 1.468, year: 2016 http://library.utia.cas.cz/separaty/2016/RO/filip-0452917.pdf

  9. Integration of fermentation and cooling crystallisation to produce organic acids

    NARCIS (Netherlands)

    Roa Engel, C.A.

    2010-01-01

    Fermentation products are gaining more attention in the last years due to the fact that the metabolic and genetic engineering field has been developing techniques to enhance fermentation yields and make biochemical processes competitive compared to traditional chemical production. However, as

  10. Thermal Evolution and Crystallisation Regimes of the Martian Core

    Science.gov (United States)

    Davies, C. J.; Pommier, A.

    2015-12-01

    Though it is accepted that Mars has a sulfur-rich metallic core, its chemical and physical state as well as its time-evolution are still unconstrained and debated. Several lines of evidence indicate that an internal magnetic field was once generated on Mars and that this field decayed around 3.7-4.0 Gyrs ago. The standard model assumes that this field was produced by a thermal (and perhaps chemical) dynamo operating in the Martian core. We use this information to construct parameterized models of the Martian dynamo in order to place constraints on the thermochemical evolution of the Martian core, with particular focus on its crystallization regime. Considered compositions are in the FeS system, with S content ranging from ~10 and 16 wt%. Core radius, density and CMB pressure are varied within the errors provided by recent internal structure models that satisfy the available geodetic constraints (planetary mass, moment of inertia and tidal Love number). We also vary the melting curve and adiabat, CMB heat flow and thermal conductivity. Successful models are those that match the dynamo cessation time and fall within the bounds on present-day CMB temperature. The resulting suite of over 500 models suggest three possible crystallization regimes: growth of a solid inner core starting at the center of the planet; freezing and precipitation of solid iron (Fe- snow) from the core-mantle boundary (CMB); and freezing that begins midway through the core. Our analysis focuses on the effects of core properties that are expected to be constrained during the forthcoming Insight mission.

  11. Investigation of growth rate dispersion in lactose crystallisation by AFM

    Science.gov (United States)

    Dincer, T. D.; Ogden, M. I.; Parkinson, G. M.

    2014-09-01

    α-Lactose monohydrate crystals have been reported to exhibit growth rate dispersion (GRD). Variation in surface dislocations has been suggested as the cause of GRD, but this has not been further investigated to date. In this study, growth rate dispersion and the change in morphology were investigated in situ and via bottle roller experiments. The surfaces of the (0 1 0) faces of crystals were examined with Atomic Force Microscopy. Smaller, slow growing crystals tend to have smaller (0 1 0) faces with narrow bases and displayed a single double spiral in the centre of the crystal with 2 nm high steps. Additional double spirals in other crystals resulted in faster growth rates. Large, fast growing crystals were observed to have larger (0 1 0) faces with fast growth in both the a and b directions (giving a broader crystal base) with macro steps parallel to the (c direction). The number and location of spirals or existence of macro steps appears to influence the crystal morphology, growth rates and growth rate dispersion in lactose crystals.

  12. Modelling the crystallisation of alkaline earth boroaluminosilicate glass ceramics

    DEFF Research Database (Denmark)

    Svenson, Mouritz Nolsøe; Agersted, Karsten; Holm, Paul Martin

    2014-01-01

    To investigate the potential use of a thermochemical software package (FactSage 6.2), in the design of alkaline earth boroaluminosilicate glass ceramics, experimental and modelled results on four glass ceramics were compared. Initially large discrepancies were found. These are described and related...

  13. Hugoniot curve of vitreous silica and crystallisation under shock

    International Nuclear Information System (INIS)

    Viard, Jean

    1959-01-01

    The Hugoniot curve of vitreous silica shows a discontinuity of slope towards 135 kb, a sign of the passage, from the vitreous state to a crystalline structure in the shock wave. Reprint of a paper published in Comptes rendus des seances de l'Academie des Sciences, t. 249, p. 820-822, sitting of 10 August 1959 [fr

  14. Risoe DTU annual report 2009. Highlights from Risoe National Laboratory for Sustainable Energy, DTU

    Energy Technology Data Exchange (ETDEWEB)

    Pedersen, Birgit; Bindslev, H. (eds.)

    2010-06-15

    Risoe DTU is the National Laboratory for Sustainable Energy at the Technical University of Denmark. The research focuses on development of energy technologies and systems with minimal effect on climate, and contributes to innovation, education and policy. Risoe has large experimental facilities and interdisciplinary research environments, and includes the national centre for nuclear technologies. The 2009 annual report gives highlights on Risoe's research in the following areas: wind energy, bioenergy, solar energy, fusion energy, fuel cells and hydrogen, energy systems and climate change, and nuclear technologies. It also includes information on Education and training, Innovation and business, Research facilities, and Management, Personnel and Operating statements. (LN)

  15. Selection, Appraisal, and Retention of Digital Scientific Data: Highlights of an ERPANET/CODATA Workshop

    Directory of Open Access Journals (Sweden)

    E Esanu

    2006-01-01

    Full Text Available CODATA and ERPANET collaborated to convene an international archiving workshop on the selection, appraisal, and retention of digital scientific data, which was held on 15-17 December 2003 at the Biblioteca Nacional in Lisbon, Portugal. The workshop brought together more than 65 researchers, data and information managers, archivists, and librarians from 13 countries to discuss the issues involved in making critical decisions regarding the long-term preservation of the scientific record. One of the major aims for this workshop was to provide an international forum to exchange information about data archiving policies and practices across different scientific, institutional, and national contexts. Highlights from the workshop discussions are presented.

  16. Environmental programs of the Department of Energy and Environment annual highlights

    International Nuclear Information System (INIS)

    Manowitz, B.

    1978-12-01

    Environmental Sciences is one of the four areas comprising the Department of Energy and Environment at Brookhaven National Laboratory. It carries out a wide range of activities in atmospheric sciences, environmental chemistry, oceanographic sciences, and land and freshwater environmental sciences. In general, these programs are concerned with identification and measurement of pollutants introduced into the environment by energy-related activities and the evaluation and prediction of the effects or potential effects of these pollutants on the environment. This highlights report for Environmental Programs covers the year 1978 and describes the objectives and funding levels of each of the programs, major accomplishments during the year, planned future activities, and current publications

  17. Highlights from the CERN/ESO/NordForsk ''Gender in Physics Day''

    Science.gov (United States)

    Primas, F.; Guinot, G.; Strandberg, L.

    2017-03-01

    In their role as observers on the EU Gender Equality Network in the European Research Area (GENERA) project, funded under the Horizon 2020 framework, CERN, ESO and NordForsk joined forces and organised a Gender in Physics Day at the CERN Globe of Science and Innovation. The one-day conference aimed to examine innovative activities promoting gender equality, and to discuss gender-oriented policies and best practice in the European Research Area (with special emphasis on intergovernmental organisations), as well as the importance of building solid networks. The event was very well attended and was declared a success. The main highlights of the meeting are reported.

  18. Retroperitoneal Inflammatory Liposarcoma in a Patient with Non-Hodgkin Lymphoma: A Report Highlighting Diagnostic Pitfalls

    Directory of Open Access Journals (Sweden)

    Cathy S. Lim

    2010-01-01

    Full Text Available Well differentiated liposarcoma (WDLS is the commonest subtype of liposarcoma. Recognised subtypes of WDLSs are lipoma-like, sclerosing, spindle cell and inflammatory. The inflammatory variant of WDLS also known as “lymphocyte-rich liposarcoma” is rare. We present a case of inflammatory WDLS occurring in the retroperitoneum, in a patient with a past history of non-Hodgkin lymphoma. We outline the histological features, discuss the differential diagnoses and highlight the diagnostic pitfalls in interpretation of this lesion on fine needle biopsy.

  19. Highlights of proposed changes to ANSI/ASME N509-80

    International Nuclear Information System (INIS)

    Ornberg, S.C.

    1987-01-01

    The ASME Committee on Nuclear Air and Gas Treatment (CONAGT) are at the time of this writing considering performing maintenance revisions of ANSI N509 and N510 based on the results of a required 5-year review and comments received from users of the standards at workshops and through inquiries. This paper discusses the highlights of the significant revisions to ANSI/ASME N509 and explains the reasons for the changes. It should be emphasized that these revisions are not yet approved by ASME CONAGT, the board of Nuclear Codes and Standards, or ANSI

  20. Risoe DTU annual report 2008. Highlights from Risoe National Laboratory for Sustainable Energy, DTU

    International Nuclear Information System (INIS)

    Pedersen, Birgit; Bindslev, H.

    2009-08-01

    Risoe DTU is the National Laboratory for Sustainable Energy at the Technical University of Denmark. The research focuses on development of energy technologies and systems with minimal effect on climate, and contributes to innovation, education and policy. Risoe has large experimental facilities and interdisciplinary research environments, and includes the national centre for nuclear technologies. The 2008 annual report gives highlights on Risoe's research in the following areas: wind energy, bioenergy, solar energy, fusion energy, fuel cells and hydrogen, energy systems and climate change, and nuclear technologies. It also includes information on Education and training, Innovation and business, Research facilities, and Management, Personnel and Operating statements. (LN)

  1. Risoe DTU annual report 2008. Highlights from Risoe National Laboratory for Sustainable Energy, DTU

    Energy Technology Data Exchange (ETDEWEB)

    Pedersen, Birgit; Bindslev, H. (eds.)

    2009-08-15

    Risoe DTU is the National Laboratory for Sustainable Energy at the Technical University of Denmark. The research focuses on development of energy technologies and systems with minimal effect on climate, and contributes to innovation, education and policy. Risoe has large experimental facilities and interdisciplinary research environments, and includes the national centre for nuclear technologies. The 2008 annual report gives highlights on Risoe's research in the following areas: wind energy, bioenergy, solar energy, fusion energy, fuel cells and hydrogen, energy systems and climate change, and nuclear technologies. It also includes information on Education and training, Innovation and business, Research facilities, and Management, Personnel and Operating statements. (LN)

  2. Highlighting micrographic structures of uranium-zirconium alloys with 6 per cent of weight of Zr

    International Nuclear Information System (INIS)

    Bouleau, Maurice

    1961-01-01

    In order to study the transformation kinetics of U-Zr alloys with a Zr content of 6 per cent in weight, the authors searched for a slow enough electrolytic polishing bath, and for an attack and examination method to highlight martensite structures produced by austempering and water tempering, and ultra-fine decomposition structures obtained by austempering. The authors explain the choice of a perchloric-butyl glycol polishing bath, of an examination under polarized light or normal light after appropriate attacks. These studies are reported for annealed alloys, and for processed alloys with martensite or ultra-fine decomposition structures [fr

  3. Environmental programs of the Department of Energy and Environment annual highlights

    Energy Technology Data Exchange (ETDEWEB)

    Manowitz, B

    1978-12-01

    Environmental Sciences is one of the four areas comprising the Department of Energy and Environment at Brookhaven National Laboratory. It carries out a wide range of activities in atmospheric sciences, environmental chemistry, oceanographic sciences, and land and freshwater environmental sciences. In general, these programs are concerned with identification and measurement of pollutants introduced into the environment by energy-related activities and the evaluation and prediction of the effects or potential effects of these pollutants on the environment. This highlights report for Environmental Programs covers the year 1978 and describes the objectives and funding levels of each of the programs, major accomplishments during the year, planned future activities, and current publications.

  4. The highlighting of an internal combustion engine piston ring radial oscillations

    Directory of Open Access Journals (Sweden)

    Djallel ZEBBAR

    2016-06-01

    Full Text Available This paper deals with the definition of the lube-oil film thickness in the piston ring cylinder liner junction of an internal combustion engine. At first, a mathematical model for the estimation of the film thickness is established. It is used to point out the oscillating motion of the piston ring normal to the cylinder wall. For the first time, has been highlighted and analytically evaluated the oscillating behavior of the piston ring in its housing in the radial direction. Furthermore, it is demonstrated that the radial oscillations frequency is a function of piston ring stiffness, material and geometry.

  5. EMSL Quarterly Highlights Report Second Quarter, Fiscal Year 2010 (January 1, 2010 through March 31, 2010)

    Energy Technology Data Exchange (ETDEWEB)

    West, Staci A.; Showalter, Mary Ann; Manke, Kristin L.; Carper, Ross R.; Wiley, Julie G.; Beckman, Mary T.

    2010-04-20

    The Environmental Molecular Sciences Laboratory (EMSL) is a U.S. Department of Energy (DOE) national scientific user facility located at Pacific Northwest National Laboratory (PNNL) in Richland, Washington. EMSL is operated by PNNL for the DOE-Office of Biological and Environmental Research. At one location, EMSL offers a comprehensive array of leading-edge resources and expertise. Access to the instrumentation and expertise is obtained on a peer-reviewed proposal basis. Staff members work with researchers to expedite access to these capabilities. The "EMSL Quarterly Highlights Report" documents current research and activities of EMSL staff and users.

  6. Princeton Plasma Physics Laboratory - 1995 Highlights. Fiscal Year 1995, 1 October 1994--30 September 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    The purpose of this Highlights Report is to present a brief overview of the Laboratory`s significant research accomplishments during the fiscal year 1995. The activities covered in this report include advances on the large projects, such as the discovery of the Enhanced Reversed Shear mode on the TFTR and the engineering design developments in the International Thermonuclear Experimental Reactor project, as well as the significant progress made in plasma theory, small-scale experiments, technology transfer, graduate education, and the Laboratory`s outreach program in science education.

  7. Highlighting micrographic structures of uranium alloys containing 0.5 to 10 per cent wt molybdenum

    International Nuclear Information System (INIS)

    Laniesse, J.; Bouleau, M.

    1959-02-01

    The authors report a study which aimed at determining for different uranium molybdenum alloys and with respect to their molybdenum content a polishing method which allows a relatively simple grain examination in the as-cast condition, an as perfect as possible resolution of eutectic decompositions, and the appropriate conditions to highlight structures (beta-alpha and gamma-alpha martensite transformations, beta phase retention and decomposition, transient structures, eutectoid decomposition, and so on). Alloys differ by their molybdenum content: from 0.5 to 1 per cent wt, 1.5 to 3 per cent wt, 5 to 10 per cent wt

  8. Event displays highlighting the main properties of heavy flavour jets in the CMS Experiment

    CERN Multimedia

    Skovpen, Kirill

    2017-01-01

    A broad range of physics analyses at CMS rely on the efficient identification of heavy flavour jets. Identification of these objects is a challenging task, especially in the presence of a large number of multiple interactions per bunch crossing. The presented summary contains a set of graphical displays of reconstructed events in data collected by CMS in proton-proton collisions at 13 TeV in 2016. The displays highlight the main properties of heavy flavour jets in several event topologies, including QCD multijet, top quark pair, W+c and boosted H→bb.

  9. Risoe DTU annual report 2009. Highlights from Risoe National Laboratory for Sustainable Energy, DTU

    Energy Technology Data Exchange (ETDEWEB)

    Pedersen, Birgit; Bindslev, H [eds.

    2010-06-15

    Risoe DTU is the National Laboratory for Sustainable Energy at the Technical University of Denmark. The research focuses on development of energy technologies and systems with minimal effect on climate, and contributes to innovation, education and policy. Risoe has large experimental facilities and interdisciplinary research environments, and includes the national centre for nuclear technologies. The 2009 annual report gives highlights on Risoe's research in the following areas: wind energy, bioenergy, solar energy, fusion energy, fuel cells and hydrogen, energy systems and climate change, and nuclear technologies. It also includes information on Education and training, Innovation and business, Research facilities, and Management, Personnel and Operating statements. (LN)

  10. Risoe DTU annual report 2009. Highlights from Risoe National Laboratory for Sustainable Energy, DTU

    International Nuclear Information System (INIS)

    Pedersen, Birgit; Bindslev, H.

    2010-06-01

    Risoe DTU is the National Laboratory for Sustainable Energy at the Technical University of Denmark. The research focuses on development of energy technologies and systems with minimal effect on climate, and contributes to innovation, education and policy. Risoe has large experimental facilities and interdisciplinary research environments, and includes the national centre for nuclear technologies. The 2009 annual report gives highlights on Risoe's research in the following areas: wind energy, bioenergy, solar energy, fusion energy, fuel cells and hydrogen, energy systems and climate change, and nuclear technologies. It also includes information on Education and training, Innovation and business, Research facilities, and Management, Personnel and Operating statements. (LN)

  11. Multi-modal highlight generation for sports videos using an information-theoretic excitability measure

    Science.gov (United States)

    Hasan, Taufiq; Bořil, Hynek; Sangwan, Abhijeet; L Hansen, John H.

    2013-12-01

    The ability to detect and organize `hot spots' representing areas of excitement within video streams is a challenging research problem when techniques rely exclusively on video content. A generic method for sports video highlight selection is presented in this study which leverages both video/image structure as well as audio/speech properties. Processing begins where the video is partitioned into small segments and several multi-modal features are extracted from each segment. Excitability is computed based on the likelihood of the segmental features residing in certain regions of their joint probability density function space which are considered both exciting and rare. The proposed measure is used to rank order the partitioned segments to compress the overall video sequence and produce a contiguous set of highlights. Experiments are performed on baseball videos based on signal processing advancements for excitement assessment in the commentators' speech, audio energy, slow motion replay, scene cut density, and motion activity as features. Detailed analysis on correlation between user excitability and various speech production parameters is conducted and an effective scheme is designed to estimate the excitement level of commentator's speech from the sports videos. Subjective evaluation of excitability and ranking of video segments demonstrate a higher correlation with the proposed measure compared to well-established techniques indicating the effectiveness of the overall approach.

  12. Highlights and Opportunities from Continuous Access to Gas Hydrates Sites at Ocean Networks Canada's NEPTUNE Observatory

    Science.gov (United States)

    Scherwath, M.; Heesemann, M.; Riedel, M.; Thomsen, L.; Roemer, M.; Chatzievangelou, D.; Purser, A.

    2017-12-01

    Since 2009 Ocean Networks Canada provides permanent access and continuous data in near real-time from two prominent gas hydrates research sites at the Northern Cascadia Margin, Barkley Canyon and Clayoquot Slope off Vancouver Island, through power and communication cables directly from shore. We show data highlights from the seafloor crawler Wally, the world's first internet operated vehicle, in a field of hydrate mounds and outcropping gas hydrates, and its co-located sonars and state-of-the-ocean sensors and Barkley Canyon. For example, spectacular views from the benthic communities and their changes over time are captured by video. At Clayoquot Slope highly active gas seep fields are monitored with a rotating multibeam sonar and various other environmental sensors. In addition, newly installed geodetic sensors as well as an instrumented borehole in that area are now online and provide additional data on subduction-related deformation and potential links to gas discharge. These show-case examples highlight the benefits of co-located experiments that enable interdisciplinary research and also the ability for high-power and -bandwidth long-term monitoring at remote seafloor locations, that over time will provide baselines for environmental monitoring together with natural variability and potential long-term trends.

  13. Coated Particle Fuel and Deep Burn Program Monthly Highlights May 2011

    International Nuclear Information System (INIS)

    Snead, Lance Lewis; Bell, Gary L.; Besmann, Theodore M.

    2011-01-01

    During FY 2011 the CP and DB Program will report Highlights on a monthly basis, but will no longer produce Quarterly Progress Reports. Technical details that were previously included in the quarterly reports will be included in the appropriate Milestone Reports that are submitted to FCRD Program Management. These reports will also be uploaded to the Deep Burn website. The Monthly Highlights report for April 2011, ORNL/TM-2011/125, was distributed to program participants on May 10, 2011. As reported previously, the final Quarterly for FY 2010, Deep Burn Program Quarterly Report for July - September 2010, ORNL/TM-2010/301, was announced to program participants and posted to the website on December 28, 2010. This report discusses the following: (1) Fuel Performance Modeling - Fuel Performance Analysis; (2) Thermochemical Data and Model Development - (a) Thermochemical Modeling, (b) Thermomechanical Modeling, (c) Actinide and Fission Product Transport; (3) TRU (transuranic elements) TRISO (tri-structural isotropic) Development - (a) TRU Kernel Development, (b) Coating Development; and (4) LWR Fully Ceramic Fuel - (a) FCM Fabrication Development, (b) FCM Irradiation Testing.

  14. Coated Particle Fuel and Deep Burn Program Monthly Highlights June 2011

    International Nuclear Information System (INIS)

    Snead, Lance Lewis; Bell, Gary L.; Besmann, Theodore M.

    2011-01-01

    During FY 2011 the CP and DB Program will report Highlights on a monthly basis, but will no longer produce Quarterly Progress Reports. Technical details that were previously included in the quarterly reports will be included in the appropriate Milestone Reports that are submitted to FCRD Program Management. These reports will also be uploaded to the Deep Burn website. The Monthly Highlights report for May 2011, ORNL/TM-2011/126, was distributed to program participants on June 9, 2011. As reported previously, the final Quarterly for FY 2010, Deep Burn Program Quarterly Report for July - September 2010, ORNL/TM-2010/301, was announced to program participants and posted to the website on December 28, 2010. This report discusses the following: (1) Fuel Performance Modeling - Fuel Performance Analysis; (2) Thermochemical Data and Model Development - (a) Thermochemical Behavior, (b) Thermomechanical Modeling, (c) Actinide and Fission Product Transport; (3) TRU (transuranic elements) TRISO (tri-structural isotropic) Development - (a) TRU Kernel Development, (b) Coating Development; and (4) LWR Fully Ceramic Fuel - (a) FCM Fabrication Development, (b) FCM Irradiation Testing.

  15. Topographic attributes as a guide for automated detection or highlighting of geological features

    Science.gov (United States)

    Viseur, Sophie; Le Men, Thibaud; Guglielmi, Yves

    2015-04-01

    Photogrammetry or LIDAR technology combined with photography allow geoscientists to obtain 3D high-resolution numerical representations of outcrops, generally termed as Digital Outcrop Models (DOM). For over a decade, these 3D numerical outcrops serve as support for precise and accurate interpretations of geological features such as fracture traces or plans, strata, facies mapping, etc. These interpretations have the benefit to be directly georeferenced and embedded into the 3D space. They are then easily integrated into GIS or geomodeler softwares for modelling in 3D the subsurface geological structures. However, numerical outcrops generally represent huge data sets that are heavy to manipulate and hence to interpret. This may be particularly tedious as soon as several scales of geological features must be investigated or as geological features are very dense and imbricated. Automated tools for interpreting geological features from DOMs would be then a significant help to process these kinds of data. Such technologies are commonly used for interpreting seismic or medical data. However, it may be noticed that even if many efforts have been devoted to easily and accurately acquire 3D topographic point clouds and photos and to visualize accurate 3D textured DOMs, few attentions have been paid to the development of algorithms for automated detection of the geological structures from DOMs. The automatic detection of objects on numerical data generally assumes that signals or attributes computed from this data allows the recognition of the targeted object boundaries. The first step consists then in defining attributes that highlight the objects or their boundaries. For DOM interpretations, some authors proposed to use differential operators computed on the surface such as normal or curvatures. These methods generally extract polylines corresponding to fracture traces or bed limits. Other approaches rely on the PCA technology to segregate different topographic plans

  16. ITALIAN LOCAL PUBLIC SERVICES: SOME GOVERNANCE HIGHLIGHTS FROM THE LARGER CITIES’ EXPERIENCE

    Directory of Open Access Journals (Sweden)

    DE MATTEIS Fabio

    2013-06-01

    Full Text Available Entrusting most local public services to local government entities has led to proliferation of public groups and, consistently, to greater complexity of the governance dynamics of local authorities. Differently from Anglo-Saxon countries, the Italian local public services provision has been characterized by a hybrid externalization process where local entities are legally autonomous but owned by the local government. This leads to a peculiar governance complexity source represented by the dual role (stakeholder and customer assumed by the local authority. Considering these elements (hybrid externalization and governance structure, this work tries to investigate some governance issues of public groups, basing on the two most populous Italian municipalities. The empirical findings highlight a gap between the presence of the conditions for defining a group governance structure and the adoption of a group approach by the parent local government. The authors try to suggest how to bridge this gap.

  17. Highlights of the EANM Congress Barcelona 2009: increasing our impact in diagnostic imaging

    International Nuclear Information System (INIS)

    Roca, Isabel

    2010-01-01

    The EANM Congress 2009 took place in Barcelona from 10 to 14 October under the chairmanship of Dr. Martin-Comin. As always, the meeting was successful with high-level scientific content and a great number of participants. In spite of the economic crisis, industry made an important contribution presenting new revolutionary equipment and tracers, and in particular the pharmaceutical industry has increased its involvement in our speciality. This article is a brief summary of the major scientific contributions presented at the annual congress 2009, highlighting the fields of nuclear medicine at a higher level of development, including those with an increased clinical impact (especially oncology, but also cardiology, neurology and other clinical sciences), new detectors and multimodality imaging, and those fields showing important progress, including radiochemistry and pharmacy (with the development of new tracers and increased collaboration of industry). (orig.)

  18. Highlights of the 12th International Conference on Nuclear Cardiology and Cardiac CT.

    Science.gov (United States)

    Kitsiou, Anastasia; Dorbala, Sharmila; Scholte, Arthur J H A

    2015-09-01

    The 12th International Conference on Nuclear Cardiology and Cardiac CT was held from 3 to 5 May 2015 in Madrid, Spain. In this article, the three Congress Program Committee Chairs summarize selected highlights of the presented abstracts. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com. This article is being published concurrently in the Journal of Nuclear Cardiology (10.1007/s12350-015-0260-y) and European Heart Journal – Cardiovascular Imaging (10.1093/ehjci/jev179). The articles are identical except for minor stylistic and spelling differences in keeping with each journal’s style. Either citation can be used when citing this article.

  19. Brookhaven highlights, October 1978-September 1979. [October 1978 to September 1979

    Energy Technology Data Exchange (ETDEWEB)

    1979-01-01

    These highlights present an overview of the major research and development achievements at Brookhaven National Laboratory from October 1978 to September 1979. Specific areas covered include: accelerator and high energy physics programs; high energy physics research; the AGS and improvements to the AGS; neutral beam development; heavy ion fusion; superconducting power cables; ISABELLE storage rings; the BNL Tandem accelerator; heavy ion experiments at the Tandem; the High Flux Beam Reactor; medium energy physics; nuclear theory; atomic and applied physics; solid state physics; neutron scattering studies; x-ray scattering studies; solid state theory; defects and disorder in solids; surface physics; the National Synchrotron Light Source ; Chemistry Department; Biology Department; Medical Department; energy sciences; environmental sciences; energy technology programs; National Center for Analysis of Energy Systems; advanced reactor systems; nuclear safety; National Nuclear Data Center; nuclear materials safeguards; Applied Mathematics Department; and support activities. (GHT)

  20. Diagnosis and Management of Rhinosinusitis: Highlights from the 2015 Practice Parameter.

    Science.gov (United States)

    Dass, Kathleen; Peters, Anju Tripathi

    2016-04-01

    Rhinosinusitis is a commonly diagnosed disease in the USA. Rhinosinusitis is classified as acute, recurrent, or chronic (with or without nasal polyps). While acute rhinosinusitis is diagnosed by history and physical examination, chronic rhinosinusitis and recurrent acute rhinosinusitis are diagnosed based on symptoms and the presence of disease on either a sinus CT scan and/or endoscopy. Management of uncomplicated acute rhinosinusitis includes analgesics, saline irrigation, and/or intranasal steroids. Antibiotics and intranasal steroids are recommended for acute bacterial rhinosinusitis. Intranasal and oral steroids with antibiotics are recommended to treat chronic rhinosinusitis although the evidence for antibiotics is weak. Biologics such as omalizumab and mepolizumab are being investigated for the treatment of chronic rhinosinusitis with nasal polyps. Surgery may be indicated in management of refractory chronic rhinosinusitis and rarely for acute bacterial rhinosinusitis. This review discusses highlights of the updated 2014 practice parameter and up-to-date evidence from other literature sources.

  1. Translating psychological science: Highlighting the media's contribution to contagion in mass shootings: Comment on Kaslow (2015).

    Science.gov (United States)

    Perrin, Paul B

    2016-01-01

    In her presidential address, N. J. Kaslow (see record 2015-33530-002) argued that psychologists have a responsibility to translate psychological science to the public and identifies various platforms for doing so. In this comment on her article, I advocate that psychology as a field immediately heed her call in the area of psychological science highlighting the media's contribution to contagion in mass shootings. I point out the psychological science documenting media contagion for suicide and mass shootings, the World Health Organization's (2008) guidelines for media in reporting suicide deaths to prevent that contagion, and discuss ways-based on Dr. Kaslow's suggestions-that psychologists can disseminate psychological science to prevent similar tragedies in the future. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  2. Highlighting the History of Astronomy in the Asia-Pacific Region

    CERN Document Server

    Nakamura, Tsuko; Strom, Richard G; ICOA-6 Conference

    2011-01-01

    This book provides readers with the results of recent research from some of the world's leading historians of astronomy on aspects of Arabic, Australian, Chinese, Japanese, and North and South American astronomy and astrophysics. It contains peer-reviewed papers gathered from the International Conferences on Oriental Astronomy 6 (ICO-6) with the chosen theme of "Highlighting the History of Astronomy in the Asia-Pacific Region." Of particular note are the sections on Arabic astronomy, Asian applied astronomy and the history of Australian radio astronomy, and the chapter on Peruvian astronomy. This title is a valuable complement for those with research interests in applied historical astronomy; archaeoastronomy; calendars, manuscripts, and star charts; historical instruments and observatories, and the history of radio astronomy.

  3. Differential proteomic analysis highlights metabolic strategies associated with balhimycin production in Amycolatopsis balhimycina chemostat cultivations

    DEFF Research Database (Denmark)

    Gallo, Giuseppe; Alduina, Rosa; Renzone, Giovanni

    2010-01-01

    Background Proteomics was recently used to reveal enzymes whose expression is associated with the production of the glycopeptide antibiotic balhimycin in Amycolatopsis balhimycina batch cultivations. Combining chemostat fermentation technology, where cells proliferate with constant parameters...... in a highly reproducible steady-state, and differential proteomics, the relationships between physiological status and metabolic pathways during antibiotic producing and non-producing conditions could be highlighted. Results Two minimal defined media, one with low Pi (0.6 mM; LP) and proficient glucose (12 g....../l) concentrations and the other one with high Pi (1.8 mM) and limiting (6 g/l; LG) glucose concentrations, were developed to promote and repress antibiotic production, respectively, in A. balhimycina chemostat cultivations. Applying the same dilution rate (0.03 h-1), both LG and LP chemostat cultivations showed...

  4. Highlights of the SLD Physics Program at the SLAC Linear Collider

    International Nuclear Information System (INIS)

    Willocq, Stephane

    2001-01-01

    Starting in 1989, and continuing through the 1990s, high-energy physics witnessed a flowering of precision measurements in general and tests of the standard model in particular, led by e + e - collider experiments operating at the Z 0 resonance. Key contributions to this work came from the SLD collaboration at the SLAC Linear Collider. By exploiting the unique capabilities of this pioneering accelerator and the SLD detector, including a polarized electron beam, exceptionally small beam dimensions, and a CCD pixel vertex detector, SLD produced a broad array of electroweak, heavy-flavor, and QCD measurements. Many of these results are one of a kind or represent the world's standard in precision. This article reviews the highlights of the SLD physics program, with an eye toward associated advances in experimental technique, and the contribution of these measurements to our dramatically improved present understanding of the standard model and its possible extensions

  5. Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo.

    Science.gov (United States)

    Whittington, Camilla M; O'Meally, Denis; Laird, Melanie K; Belov, Katherine; Thompson, Michael B; McAllan, Bronwyn M

    2018-02-05

    Early pregnancy is a critical time for successful reproduction; up to half of human pregnancies fail before the development of the definitive chorioallantoic placenta. Unlike the situation in eutherian mammals, marsupial pregnancy is characterised by a long pre-implantation period prior to the development of the short-lived placenta, making them ideal models for study of the uterine environment promoting embryonic survival pre-implantation. Here we present a transcriptomic study of pre-implantation marsupial pregnancy, and identify differentially expressed genes in the Sminthopsis crassicaudata uterus involved in metabolism and biosynthesis, transport, immunity, tissue remodelling, and uterine receptivity. Interestingly, almost one quarter of the top 50 genes that are differentially upregulated in early pregnancy are putatively involved in histotrophy, highlighting the importance of nutrient transport to the conceptus prior to the development of the placenta. This work furthers our understanding of the mechanisms underlying survival of pre-implantation embryos in the earliest live bearing ancestors of mammals.

  6. Natural Variation in Banana Varieties Highlights the Role of Melatonin in Postharvest Ripening and Quality.

    Science.gov (United States)

    Hu, Wei; Yang, Hai; Tie, Weiwei; Yan, Yan; Ding, Zehong; Liu, Yang; Wu, Chunlai; Wang, Jiashui; Reiter, Russel J; Tan, Dun-Xian; Shi, Haitao; Xu, Biyu; Jin, Zhiqiang

    2017-11-22

    This study aimed to investigate the role of melatonin in postharvest ripening and quality in various banana varieties with contrasting ripening periods. During the postharvest life, endogenous melatonin showed similar performance with ethylene in connection to ripening. In comparison to ethylene, melatonin was more correlated with postharvest banana ripening. Exogenous application of melatonin resulted in a delay of postharvest banana ripening. Moreover, this effect is concentration-dependent, with 200 and 500 μM treatments more effective than the 50 μM treatment. Exogenous melatonin also led to elevated endogenous melatonin content, reduced ethylene production through regulation of the expression of MaACO1 and MaACS1, and delayed sharp changes of quality indices. Taken together, this study highlights that melatonin is an indicator for banana fruit ripening in various varieties, and the repression of ethylene biosynthesis and postharvest ripening by melatonin can be used for biological control of postharvest fruit ripening and quality.

  7. Highlights of the SLD Physics Program at the SLAC Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Willocq, Stephane

    2001-09-07

    Starting in 1989, and continuing through the 1990s, high-energy physics witnessed a flowering of precision measurements in general and tests of the standard model in particular, led by e{sup +}e{sup -} collider experiments operating at the Z{sup 0} resonance. Key contributions to this work came from the SLD collaboration at the SLAC Linear Collider. By exploiting the unique capabilities of this pioneering accelerator and the SLD detector, including a polarized electron beam, exceptionally small beam dimensions, and a CCD pixel vertex detector, SLD produced a broad array of electroweak, heavy-flavor, and QCD measurements. Many of these results are one of a kind or represent the world's standard in precision. This article reviews the highlights of the SLD physics program, with an eye toward associated advances in experimental technique, and the contribution of these measurements to our dramatically improved present understanding of the standard model and its possible extensions.

  8. Highlights from panel discussion on key issues for future developments in microwave processing

    International Nuclear Information System (INIS)

    Gac, F.D.; Iskander, M.F.

    1992-01-01

    This paper reports on highlights from a panel discussion on Key Issues for Future Development in Microwave Processing. Although the panelists represented a mix of individuals from government, academia, and industry, only one aspect of industry was represented, namely microwave system manufacturers. For further panel discussions, it is recommended that the materials manufacturing (i.e., microwave user) sector also be represented. Three important points emerged from the panel discussion. The first deals with the credibility and usability of information, be it dielectric property measurements, experimental procedures, or microwave processing results. Second, a considerable communication and education gap continues to exist between the materials community and microwave engineers. Finally, a more realistic approach should be taken in identifying where microwave processing makes sense

  9. Thermal hydraulics of sodium-cooled fast reactors - key issues and highlights

    International Nuclear Information System (INIS)

    Ninokata, H.; Kamide, H.

    2011-01-01

    In this paper key issues and highlighted topics in thermal hydraulics are discussed in connection to the current Japan's sodium-cooled fast reactor development efforts. In particular, design study and related researches of the Japan Sodium-cooled Fast Reactor (JSFR) are focused. Several innovative technologies, e.g., compact reactor vessel, two-loop system, fully natural circulation decay heat removal, and recriticality free core, have been investigated in order to reduce construction cost and to achieve higher level of reactor safety. Preliminary evaluations of innovative technologies to be applied to JSFR are on-going. Here, progress of design study is introduced. Then, research and development activities on the thermal hydraulics related to the innovative technologies are briefly reviewed. (author)

  10. Bioanalysis-related highlights from the 2011 AAPS National Biotechnology Conference.

    Science.gov (United States)

    Crisino, Rebecca M; Dulanto, Beatriz

    2011-08-01

    The American Association of Pharmaceutical Scientists is a dynamic international forum for the exchange of knowledge among scientists to enhance their contributions to drug development. The annual National Biotechnology Conference, conducted and organized by the American Association of Pharmaceutical Scientists, is a forum dedicated to advancements in science and technology related to discovery, development and manufacture of medical biotechnology products. The 2011 National Biotechnology Conference meeting convened in San Francisco, CA, USA on 16-18 May. Over 300 abstracts were submitted and approximately 50 sessions examined topics pertaining to advances in drug development, emerging analytical technologies, bioanalysis-related issues, biosimilar therapies, updates on global regulatory documents and expectations, and other topics. The focus of this article is to highlight key developments relevant to immunogenicity and pharmacokinetic drug concentration bioanalysis.

  11. Conference report: Bioanalysis highlights from the 2012 American Association of Pharmaceutical Scientists National Biotechnology Conference.

    Science.gov (United States)

    Crisino, Rebecca M; Geist, Brian; Li, Jian

    2012-09-01

    The American Association of Pharmaceutical Scientists (AAPS) is an international forum for the exchange of knowledge among scientists to enhance their contributions to drug development. The annual National Biotechnology Conference, organized by the AAPS on 21-23 May 2012 in San Diego, CA, USA, brings together experts from various disciplines representing private industry, academia and governing institutions dedicated toward advancing the scientific and technological progress related to discovery, development and manufacture of medical biotechnology products. Over 300 scientific poster presentations and approximately 50 oral presentation and discussion sessions examined a breadth of topics pertaining to biotechnology drug development, such as the advancement of vaccines and biosimilars, emerging and innovative technologies, nonclinical and clinical bioanalysis, and regulatory updates. This conference report highlights the existing challenges with ligand-binding assays, emerging challenges, innovative integration of various technology platforms and applicable regulatory considerations as they relate to immunogenicity and pharmacokinetic bioanalytical assessments.

  12. B-physics and quarkonium highlights and recent results from ATLAS

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    Studies of heavy flavour quark-antiquark bound states provide unique insights into the picture of strong interactions near the boundary between the perturbative and non-perturbative regimes. Despite the 40-year history since the discovery of the J/psi, quarkonia still challenge both theory and experiment. Data collected in Run 1 has now produced a comprehensive suite of measurements for a range of energies, states and decay modes. The open beauty sector tests a variety of theoretical models and provides sensitivity to beyond-standard-model processes through precision measurements, such as studies of CP violation. Highlights and most recent measurements from the B-physics and quarkonium programmes of the ATLAS experiment will be presented.

  13. Visual content highlighting via automatic extraction of embedded captions on MPEG compressed video

    Science.gov (United States)

    Yeo, Boon-Lock; Liu, Bede

    1996-03-01

    Embedded captions in TV programs such as news broadcasts, documentaries and coverage of sports events provide important information on the underlying events. In digital video libraries, such captions represent a highly condensed form of key information on the contents of the video. In this paper we propose a scheme to automatically detect the presence of captions embedded in video frames. The proposed method operates on reduced image sequences which are efficiently reconstructed from compressed MPEG video and thus does not require full frame decompression. The detection, extraction and analysis of embedded captions help to capture the highlights of visual contents in video documents for better organization of video, to present succinctly the important messages embedded in the images, and to facilitate browsing, searching and retrieval of relevant clips.

  14. Highlights of X-Stack ExM Deliverable: MosaStore

    Energy Technology Data Exchange (ETDEWEB)

    Ripeanu, Matei [Univ. of British Columbia, Vancouver, BC (Canada)

    2016-07-20

    This brief report highlights the experience gained with MosaStore, an exploratory part of the X-Stack project “ExM: System support for extreme-scale, many-task applications”. The ExM project proposed to use concurrent workflows supported by the Swift language and runtime as an innovative programming model to exploit parallelism in exascale computers. MosaStore aims to support this endeavor by improving storage support for workflow-based applications, more precisely by exploring the gains that can be obtained from co-designing the storage system and the workflow runtime engine. MosaStore has been developed primarily at the University of British Columbia.

  15. Highlighting ethical decisions underlying the scoring of animal welfare in the Welfare Quality® scheme

    DEFF Research Database (Denmark)

    Veissier, I.; Jensen, Karsten Klint; Botreau, R.

    2011-01-01

    dimension of scoring and labelling does not mean that we should reject them, but it does mean that we need to make the normative and ethical background explicit. The Welfare Quality® scoring system is used as a case study in order to highlight the role of underlying value-based decisions. In this scoring......, but the rules governing the assignment of an animal unit to a category take into account what had been observed on European farms. The scientists behind Welfare Quality® are keen to make the value-based choices underlying assessments of animal welfare transparent. This is essential to allow stakeholder groups......All systems of scoring animal units (groups, farms, slaughter plants, etc.) according to the level of the animals’ welfare are based inevitably on normative decisions. Similarly, all methods of labelling, in terms of acceptability, are based on choices reflecting ethical values. The evaluative...

  16. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    Science.gov (United States)

    Arking, Dan E.; Pulit, Sara L.; Crotti, Lia; van der Harst, Pim; Munroe, Patricia B.; Koopmann, Tamara T.; Sotoodehnia, Nona; Rossin, Elizabeth J.; Morley, Michael; Wang, Xinchen; Johnson, Andrew D.; Lundby, Alicia; Gudbjartsson, Daníel F.; Noseworthy, Peter A.; Eijgelsheim, Mark; Bradford, Yuki; Tarasov, Kirill V.; Dörr, Marcus; Müller-Nurasyid, Martina; Lahtinen, Annukka M.; Nolte, Ilja M.; Smith, Albert Vernon; Bis, Joshua C.; Isaacs, Aaron; Newhouse, Stephen J.; Evans, Daniel S.; Post, Wendy S.; Waggott, Daryl; Lyytikäinen, Leo-Pekka; Hicks, Andrew A.; Eisele, Lewin; Ellinghaus, David; Hayward, Caroline; Navarro, Pau; Ulivi, Sheila; Tanaka, Toshiko; Tester, David J.; Chatel, Stéphanie; Gustafsson, Stefan; Kumari, Meena; Morris, Richard W.; Naluai, Åsa T.; Padmanabhan, Sandosh; Kluttig, Alexander; Strohmer, Bernhard; Panayiotou, Andrie G.; Torres, Maria; Knoflach, Michael; Hubacek, Jaroslav A.; Slowikowski, Kamil; Raychaudhuri, Soumya; Kumar, Runjun D.; Harris, Tamara B.; Launer, Lenore J.; Shuldiner, Alan R.; Alonso, Alvaro; Bader, Joel S.; Ehret, Georg; Huang, Hailiang; Kao, W.H. Linda; Strait, James B.; Macfarlane, Peter W.; Brown, Morris; Caulfield, Mark J.; Samani, Nilesh J.; Kronenberg, Florian; Willeit, Johann; Smith, J. Gustav; Greiser, Karin H.; zu Schwabedissen, Henriette Meyer; Werdan, Karl; Carella, Massimo; Zelante, Leopoldo; Heckbert, Susan R.; Psaty, Bruce M.; Rotter, Jerome I.; Kolcic, Ivana; Polašek, Ozren; Wright, Alan F.; Griffin, Maura; Daly, Mark J.; Arnar, David O.; Hólm, Hilma; Thorsteinsdottir, Unnur; Denny, Joshua C.; Roden, Dan M.; Zuvich, Rebecca L.; Emilsson, Valur; Plump, Andrew S.; Larson, Martin G.; O'Donnell, Christopher J.; Yin, Xiaoyan; Bobbo, Marco; D'Adamo, Adamo P.; Iorio, Annamaria; Sinagra, Gianfranco; Carracedo, Angel; Cummings, Steven R.; Nalls, Michael A.; Jula, Antti; Kontula, Kimmo K.; Marjamaa, Annukka; Oikarinen, Lasse; Perola, Markus; Porthan, Kimmo; Erbel, Raimund; Hoffmann, Per; Jöckel, Karl-Heinz; Kälsch, Hagen; Nöthen, Markus M.; consortium, HRGEN; den Hoed, Marcel; Loos, Ruth J.F.; Thelle, Dag S.; Gieger, Christian; Meitinger, Thomas; Perz, Siegfried; Peters, Annette; Prucha, Hanna; Sinner, Moritz F.; Waldenberger, Melanie; de Boer, Rudolf A.; Franke, Lude; van der Vleuten, Pieter A.; Beckmann, Britt Maria; Martens, Eimo; Bardai, Abdennasser; Hofman, Nynke; Wilde, Arthur A.M.; Behr, Elijah R.; Dalageorgou, Chrysoula; Giudicessi, John R.; Medeiros-Domingo, Argelia; Barc, Julien; Kyndt, Florence; Probst, Vincent; Ghidoni, Alice; Insolia, Roberto; Hamilton, Robert M.; Scherer, Stephen W.; Brandimarto, Jeffrey; Margulies, Kenneth; Moravec, Christine E.; Fabiola Del, Greco M.; Fuchsberger, Christian; O'Connell, Jeffrey R.; Lee, Wai K.; Watt, Graham C.M.; Campbell, Harry; Wild, Sarah H.; El Mokhtari, Nour E.; Frey, Norbert; Asselbergs, Folkert W.; Leach, Irene Mateo; Navis, Gerjan; van den Berg, Maarten P.; van Veldhuisen, Dirk J.; Kellis, Manolis; Krijthe, Bouwe P.; Franco, Oscar H.; Hofman, Albert; Kors, Jan A.; Uitterlinden, André G.; Witteman, Jacqueline C.M.; Kedenko, Lyudmyla; Lamina, Claudia; Oostra, Ben A.; Abecasis, Gonçalo R.; Lakatta, Edward G.; Mulas, Antonella; Orrú, Marco; Schlessinger, David; Uda, Manuela; Markus, Marcello R.P.; Völker, Uwe; Snieder, Harold; Spector, Timothy D.; Ärnlöv, Johan; Lind, Lars; Sundström, Johan; Syvänen, Ann-Christine; Kivimaki, Mika; Kähönen, Mika; Mononen, Nina; Raitakari, Olli T.; Viikari, Jorma S.; Adamkova, Vera; Kiechl, Stefan; Brion, Maria; Nicolaides, Andrew N.; Paulweber, Bernhard; Haerting, Johannes; Dominiczak, Anna F.; Nyberg, Fredrik; Whincup, Peter H.; Hingorani, Aroon; Schott, Jean-Jacques; Bezzina, Connie R.; Ingelsson, Erik; Ferrucci, Luigi; Gasparini, Paolo; Wilson, James F.; Rudan, Igor; Franke, Andre; Mühleisen, Thomas W.; Pramstaller, Peter P.; Lehtimäki, Terho J.; Paterson, Andrew D.; Parsa, Afshin; Liu, Yongmei; van Duijn, Cornelia; Siscovick, David S.; Gudnason, Vilmundur; Jamshidi, Yalda; Salomaa, Veikko; Felix, Stephan B.; Sanna, Serena; Ritchie, Marylyn D.; Stricker, Bruno H.; Stefansson, Kari; Boyer, Laurie A.; Cappola, Thomas P.; Olsen, Jesper V.; Lage, Kasper; Schwartz, Peter J.; Kääb, Stefan; Chakravarti, Aravinda; Ackerman, Michael J.; Pfeufer, Arne; de Bakker, Paul I.W.; Newton-Cheh, Christopher

    2014-01-01

    The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal Mendelian Long QT Syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals we identified 35 common variant QT interval loci, that collectively explain ∼8-10% of QT variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 novel QT loci in 298 unrelated LQTS probands identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode for proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies novel candidate genes for ventricular arrhythmias, LQTS,and SCD. PMID:24952745

  17. Using qualitative problem-solving strategies to highlight the role of conceptual knowledge in solving problems

    Science.gov (United States)

    Leonard, William J.; Dufresne, Robert J.; Mestre, Jose P.

    1996-12-01

    We report on the use of qualitative problem-solving strategies in teaching an introductory, calculus-based physics course as a means of highlighting the role played by conceptual knowledge in solving problems. We found that presenting strategies during lectures and in homework solutions provides an excellent opportunity to model for students the type of concept-based, qualitative reasoning that is valued in our profession, and that student-generated strategies serve a diagnostic function by providing instructors with insights on students' conceptual understanding and reasoning. Finally, we found strategies to be effective pedagogical tools for helping students both to identify principles that could be applied to solve specific problems, as well as to recall the major principles covered in the course months after it was over.

  18. Scale effect challenges in urban hydrology highlighted with a distributed hydrological model

    Science.gov (United States)

    Ichiba, Abdellah; Gires, Auguste; Tchiguirinskaia, Ioulia; Schertzer, Daniel; Bompard, Philippe; Ten Veldhuis, Marie-Claire

    2018-01-01

    Hydrological models are extensively used in urban water management, development and evaluation of future scenarios and research activities. There is a growing interest in the development of fully distributed and grid-based models. However, some complex questions related to scale effects are not yet fully understood and still remain open issues in urban hydrology. In this paper we propose a two-step investigation framework to illustrate the extent of scale effects in urban hydrology. First, fractal tools are used to highlight the scale dependence observed within distributed data input into urban hydrological models. Then an intensive multi-scale modelling work is carried out to understand scale effects on hydrological model performance. Investigations are conducted using a fully distributed and physically based model, Multi-Hydro, developed at Ecole des Ponts ParisTech. The model is implemented at 17 spatial resolutions ranging from 100 to 5 m. Results clearly exhibit scale effect challenges in urban hydrology modelling. The applicability of fractal concepts highlights the scale dependence observed within distributed data. Patterns of geophysical data change when the size of the observation pixel changes. The multi-scale modelling investigation confirms scale effects on hydrological model performance. Results are analysed over three ranges of scales identified in the fractal analysis and confirmed through modelling. This work also discusses some remaining issues in urban hydrology modelling related to the availability of high-quality data at high resolutions, and model numerical instabilities as well as the computation time requirements. The main findings of this paper enable a replacement of traditional methods of model calibration by innovative methods of model resolution alteration based on the spatial data variability and scaling of flows in urban hydrology.

  19. Genome, secretome and glucose transport highlight unique features of the protein production host Pichia pastoris

    Directory of Open Access Journals (Sweden)

    Mattanovich Diethard

    2009-06-01

    Full Text Available Abstract Background Pichia pastoris is widely used as a production platform for heterologous proteins and model organism for organelle proliferation. Without a published genome sequence available, strain and process development relied mainly on analogies to other, well studied yeasts like Saccharomyces cerevisiae. Results To investigate specific features of growth and protein secretion, we have sequenced the 9.4 Mb genome of the type strain DSMZ 70382 and analyzed the secretome and the sugar transporters. The computationally predicted secretome consists of 88 ORFs. When grown on glucose, only 20 proteins were actually secreted at detectable levels. These data highlight one major feature of P. pastoris, namely the low contamination of heterologous proteins with host cell protein, when applying glucose based expression systems. Putative sugar transporters were identified and compared to those of related yeast species. The genome comprises 2 homologs to S. cerevisiae low affinity transporters and 2 to high affinity transporters of other Crabtree negative yeasts. Contrary to other yeasts, P. pastoris possesses 4 H+/glycerol transporters. Conclusion This work highlights significant advantages of using the P. pastoris system with glucose based expression and fermentation strategies. As only few proteins and no proteases are actually secreted on glucose, it becomes evident that cell lysis is the relevant cause of proteolytic degradation of secreted proteins. The endowment with hexose transporters, dominantly of the high affinity type, limits glucose uptake rates and thus overflow metabolism as observed in S. cerevisiae. The presence of 4 genes for glycerol transporters explains the high specific growth rates on this substrate and underlines the suitability of a glycerol/glucose based fermentation strategy. Furthermore, we present an open access web based genome browser http://www.pichiagenome.org.

  20. Nerve-Highlighting Fluorescent Contrast Agents for Image-Guided Surgery

    Directory of Open Access Journals (Sweden)

    Summer L. Gibbs-Strauss

    2011-03-01

    Full Text Available Nerve damage is the major morbidity of many surgeries, resulting in chronic pain, loss of function, or both. The sparing of nerves during surgical procedures is a vexing problem because surrounding tissue often obscures them. To date, systemically administered nerve-highlighting contrast agents that can be used for nerve-sparing image-guided surgery have not been reported. In the current study, physicochemical and optical properties of 4,4‘-[(2-methoxy-1,4-phenylenedi-(1E-2,1-ethenediyl]bis-benzenamine (BMB and a newly synthesized, red-shifted derivative 4-[(1E-2-[4-[(1E-2-[4-aminophenyl]ethenyl]-3-methoxyphenyl]ethenyl]-benzonitrile (GE3082 were characterized in vitro and in vivo. Both agents crossed the blood-nerve barrier and blood-brain barrier and rendered myelinated nerves fluorescent after a single systemic injection. Although both BMB and GE3082 also exhibited significant uptake in white adipose tissue, GE3082 underwent a hypsochromic shift in adipose tissue that provided a means to eliminate the unwanted signal using hyperspectral deconvolution. Dose and kinetic studies were performed in mice to determine the optimal dose and drug-imaging interval. The results were confirmed in rat and pig, with the latter used to demonstrate, for the first time, simultaneous fluorescence imaging of blood vessels and nerves during surgery using the FLARE™ (Fluorescence-Assisted Resection and Exploration imaging system. These results lay the foundation for the development of ideal nerve-highlighting fluorophores for image-guided surgery.

  1. Institut de Physique Nucleaire d'Orsay. Highlights and achievements 2008-2013

    International Nuclear Information System (INIS)

    2013-01-01

    Activities of the Institute through the 2008-2013 period, have been considerable and a detailed description of all of them would have resulted in a relatively large document. The choice was then made to only describe a selection of highlights from the activities of the different groups during the last 5 years. This concerns the five main scientific topics of the institute that are: 1- Nuclear Structure and Dynamics: The highlights described in this section concern the activities of two different research groups 'NESTER' and 'NIM'; 2 - Hadrons and Hadronic Matter: This section concerns the three teams involved in the CLASS collaboration at JLab, the HADES collaboration at GSI and the ALICE collaboration at LHC. All three are part of the group 'PHEN'; 3- Physics and Chemistry of Nuclear Energy: This section covers, on one hand, activities related to Nuclear Data and Simulations of novel option for nuclear energy production within the group 'PACS' and, on the other hand, all the activities that are performed within the 'RC (Radio-chemistry group)'; 4- Astrophysics: This section concerns nuclear astrophysics research activity at the group 'NESTER', the astro-chemistry activity at the 'NIM' group and the astro-particle activity within the 'AUGER' collaboration in the group 'PHEN'; 5 - Theory: This activity concerns mainly the 'Theory' group. Beside these five scientific topics a multidisciplinary activity based mainly on the use of accelerated nanoparticles with the TANDEM accelerator at ALTO is also described. Two additional sections are devoted in the document to summarize the activities related to: 1 -Accelerator physics and technology; 2 - Detector technology, instrumentation and data acquisition and processing. A separate paragraph gives a status report and highlights from the main facilities in the Institute such as ALTO, SUPRATECH and CACAO. The activities on 'Dosimetry' in one hand and on 'Safety and Radiation Protection' on the other hand as well as an overview

  2. Soil Contamination, Advanced integrated characterisation and time-lapse Monitoring, SoilCAM project highlights

    Science.gov (United States)

    French, H. K.; Van Der Zee, S. E.; Wehrer, M.; Godio, A.; Pedersen, L. B.; Tsocano, G.

    2013-12-01

    measurements indicate where the remaining crude oil can be found. Water samples from multilevel samplers reveal crude oil present in emulsion in the zone of groundwater fluctuations, highlighting the importance of colloidal transport. Modelling of multiphase flow of the fluctuating groundwater level explains the lack of horizontal displacement of the plume in the area. Geochemistry of the groundwater clearly indicates degradation of hydrocarbons under iron- and sulphate reducing conditions, but changes were too slow to be mapped by time-lapse geophysical measurements during the project period. MODFLOW was used to simulate the regional groundwater flow and transport in the area. Highlights of the results from both test sites will be presented as an integrated overview. Snow removal at Oslo airport

  3. Transcriptomic analysis highlights epigenetic and transcriptional regulation during zygotic embryo development of Pinus pinaster.

    Science.gov (United States)

    de Vega-Bartol, José J; Simões, Marta; Lorenz, W Walter; Rodrigues, Andreia S; Alba, Rob; Dean, Jeffrey F D; Miguel, Célia M

    2013-08-30

    It is during embryogenesis that the plant body plan is established and the meristems responsible for all post-embryonic growth are specified. The molecular mechanisms governing conifer embryogenesis are still largely unknown. Their elucidation may contribute valuable information to clarify if the distinct features of embryo development in angiosperms and gymnosperms result from differential gene regulation. To address this issue, we have performed the first transcriptomic analysis of zygotic embryo development in a conifer species (Pinus pinaster) focusing our study in particular on regulatory genes playing important roles during plant embryo development, namely epigenetic regulators and transcription factors. Microarray analysis of P. pinaster zygotic embryogenesis was performed at five periods of embryo development from early developing to mature embryos. Our results show that most changes in transcript levels occurred in the first and the last embryo stage-to-stage transitions, namely early to pre-cotyledonary embryo and cotyledonary to mature embryo. An analysis of functional categories for genes that were differentially expressed through embryogenesis highlighted several epigenetic regulation mechanisms. While putative orthologs of transcripts associated with mechanisms that target transposable elements and repetitive sequences were strongly expressed in early embryogenesis, PRC2-mediated repression of genes seemed more relevant during late embryogenesis. On the other hand, functions related to sRNA pathways appeared differentially regulated across all stages of embryo development with a prevalence of miRNA functions in mid to late embryogenesis. Identification of putative transcription factor genes differentially regulated between consecutive embryo stages was strongly suggestive of the relevance of auxin responses and regulation of auxin carriers during early embryogenesis. Such responses could be involved in establishing embryo patterning. Later in

  4. Evolution of Parallel Spindles Like genes in plants and highlight of unique domain architecture#

    Directory of Open Access Journals (Sweden)

    Consiglio Federica M

    2011-03-01

    Full Text Available Abstract Background Polyploidy has long been recognized as playing an important role in plant evolution. In flowering plants, the major route of polyploidization is suggested to be sexual through gametes with somatic chromosome number (2n. Parallel Spindle1 gene in Arabidopsis thaliana (AtPS1 was recently demonstrated to control spindle orientation in the 2nd division of meiosis and, when mutated, to induce 2n pollen. Interestingly, AtPS1 encodes a protein with a FHA domain and PINc domain putatively involved in RNA decay (i.e. Nonsense Mediated mRNA Decay. In potato, 2n pollen depending on parallel spindles was described long time ago but the responsible gene has never been isolated. The knowledge derived from AtPS1 as well as the availability of genome sequences makes it possible to isolate potato PSLike (PSL and to highlight the evolution of PSL family in plants. Results Our work leading to the first characterization of PSLs in potato showed a greater PSL complexity in this species respect to Arabidopsis thaliana. Indeed, a genomic PSL locus and seven cDNAs affected by alternative splicing have been cloned. In addition, the occurrence of at least two other PSL loci in potato was suggested by the sequence comparison of alternatively spliced transcripts. Phylogenetic analysis on 20 Viridaeplantae showed the wide distribution of PSLs throughout the species and the occurrence of multiple copies only in potato and soybean. The analysis of PSLFHA and PSLPINc domains evidenced that, in terms of secondary structure, a major degree of variability occurred in PINc domain respect to FHA. In terms of specific active sites, both domains showed diversification among plant species that could be related to a functional diversification among PSL genes. In addition, some specific active sites were strongly conserved among plants as supported by sequence alignment and by evidence of negative selection evaluated as difference between non-synonymous and

  5. "Discoveries in Planetary Sciences": Slide Sets Highlighting New Advances for Astronomy Educators

    Science.gov (United States)

    Brain, D. A.; Schneider, N. M.; Beyer, R. A.

    2010-12-01

    Planetary science is a field that evolves rapidly, motivated by spacecraft mission results. Exciting new mission results are generally communicated rather quickly to the public in the form of press releases and news stories, but it can take several years for new advances to work their way into college textbooks. Yet it is important for students to have exposure to these new advances for a number of reasons. In some cases, new work renders older textbook knowledge incorrect or incomplete. In some cases, new discoveries make it possible to emphasize older textbook knowledge in a new way. In all cases, new advances provide exciting and accessible examples of the scientific process in action. To bridge the gap between textbooks and new advances in planetary sciences we have developed content on new discoveries for use by undergraduate instructors. Called 'Discoveries in Planetary Sciences', each new discovery is summarized in a 3-slide PowerPoint presentation. The first slide describes the discovery, the second slide discusses the underlying planetary science concepts, and the third presents the big picture implications of the discovery. A fourth slide includes links to associated press releases, images, and primary sources. This effort is generously sponsored by the Division for Planetary Sciences of the American Astronomical Society, and the slide sets are available at http://dps.aas.org/education/dpsdisc/. Sixteen slide sets have been released so far covering topics spanning all sub-disciplines of planetary science. Results from the following spacecraft missions have been highlighted: MESSENGER, the Spirit and Opportunity rovers, Cassini, LCROSS, EPOXI, Chandrayan, Mars Reconnaissance Orbiter, Mars Express, and Venus Express. Additionally, new results from Earth-orbiting and ground-based observing platforms and programs such as Hubble, Keck, IRTF, the Catalina Sky Survey, HARPS, MEarth, Spitzer, and amateur astronomers have been highlighted. 4-5 new slide sets are

  6. Three decades of Cognition & Emotion: A brief review of past highlights and future prospects.

    Science.gov (United States)

    Rothermund, Klaus; Koole, Sander L

    2018-02-01

    Over the past three decades, Cognition & Emotion has been one of the world's leading outlets for emotion research. In this article, we review past highlights of and future prospects for the journal. Our tour of history covers three periods: The first period, from 1987 to 1999, was a pioneering era in which cognitive theories began to be applied to the scientific analysis of emotion. The second period, from 2000 to 2007, was characterised by a sharp increase in the number of empirical research papers, a lot of which were concerned with automatic processing biases and their implications for clinical psychology. During the third period, from 2008 to 2017, a new focus emerged on self-regulatory processes and their implications for emotion. We then turn to the present profile of Cognition & Emotion and introduce our new editorial team. Finally, we consider how the journal's future success can be continued and increased by a) providing authors with fast and high-quality feedback; b) offering attractive publication formats, including the newly introduced Registered Reports for pre-registered studies; and c) consolidating key methodological paradigms with reproducible findings.

  7. Phylogenetic profiles of all membrane transport proteins of the malaria parasite highlight new drug targets

    Directory of Open Access Journals (Sweden)

    January Weiner 3rd

    2016-08-01

    Full Text Available In order to combat the on-going malaria epidemic, discovery of new drug targets remains vital. Proteins that are essential to survival and specific to malaria parasites are key candidates. To survive within host cells, the parasites need to acquire nutrients and dispose of waste products across multiple membranes. Additionally, like all eukaryotes, they must redistribute ions and organic molecules between their various internal membrane bound compartments. Membrane transport proteins mediate all of these processes and are considered important mediators of drug resistance as well as drug targets in their own right. Recently, using advanced experimental genetic approaches and streamlined life cycle profiling, we generated a large collection of Plasmodium berghei gene deletion mutants and assigned essential gene functions, highlighting potential targets for prophylactic, therapeutic, and transmission-blocking anti-malarial drugs. Here, we present a comprehensive orthology assignment of all Plasmodium falciparum putative membrane transport proteins and provide a detailed overview of the associated essential gene functions obtained through experimental genetics studies in human and murine model parasites. Furthermore, we discuss the phylogeny of selected potential drug targets identified in our functional screen. We extensively discuss the results in the context of the functional assignments obtained using gene targeting available to date.

  8. Ciguatera fish poisoning: a first epidemic in Germany highlights an increasing risk for European countries.

    Science.gov (United States)

    Mattei, César; Vetter, Irina; Eisenblätter, Anneka; Krock, Bernd; Ebbecke, Martin; Desel, Herbert; Zimmermann, Katharina

    2014-12-01

    Toxin-producing microalgae are thriving worldwide due to coral reef destruction and global warming with major consequences on ecosystems, international trade and human health. Microalgae belonging to the family of flagellate protists, in particular dinoflagellates, secrete a variety of high-molecular-weight polyether toxins that accumulate through the marine food chain to cause disease in humans by acting as sodium channel activator toxins; ciguatera is the most frequent seafood-borne illness worldwide with 50,000 to 500,000 global incidences per annum and is usually limited to endemic areas located between 35° northern and 35° southern latitude. The rising global incidence frequency renders it a major human health problem, because no curative treatment is available yet and reliable detection assays are lacking. During the last decade ciguatera has increasingly become endemic in previously unaffected areas for two reasons: first global warming has contributed to the emergence of dinoflagellate species in subtropical and even temperate regions that previously had been constrained to tropical areas and second: in Europe globalization of fishing industry and tourism has led to a progressive increase in the number of ciguatera cases and a lack of awareness among medical personnel contributes to under-reporting. We review, through a recent ciguatera outbreak in Germany, the risk for ciguatera poisoning in Europe and highlight characteristic symptoms, current knowledge about disease pathomechanisms and treatment options.

  9. Research Integrity and Peer Review-past highlights and future directions.

    Science.gov (United States)

    Boughton, Stephanie L; Kowalczuk, Maria K; Meerpohl, Joerg J; Wager, Elizabeth; Moylan, Elizabeth C

    2018-01-01

    In May 2016, we launched Research Integrity and Peer Review , an international, open access journal with fully open peer review (reviewers are identified on their reports and named reports are published alongside the article) to provide a home for research on research and publication ethics, research reporting, and research on peer review. As the journal enters its third year, we reflect on recent events and highlights for the journal and explore how the journal is faring in terms of gender and diversity in peer review. We also share the particular interests of our Editors-in-Chief regarding models of peer review, reporting quality, common research integrity issues that arise during the publishing process, and how people interact with the published literature. We continue to encourage further research into peer review, research and publication ethics and research reporting, as we believe that all new initiatives should be evidence-based. We also remain open to constructive discussions of the developments in the field that offer new solutions.

  10. Highlights from the Electricity Sector Council's powerline technician project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-05-15

    The Electricity Sector Council completed a situational analysis of the powerline technician trade in Canada in April 2008. The purpose of the study was to provide industry partners with the opportunity to provide input into the development of the powerline trade; to assess the current workforce; to examine training and working conditions based on in-depth focus group interviews; and to demonstrate regional and provincial differences in apprenticeship development. This report presented highlights from the Electricity Sector Council's powerline technician project. Specifically, the report discussed the number of powerline apprentices entering the trade; regional differences in the powerline trade; and emerging practices for recruitment, retention, and training. Recommendations were also offered in order to address the challenges faced by the powerline trade. It was concluded that the best ways to recruit candidates in the powerline technician trade are to invest in a word-of mouth campaign, such as a coaching program; encourage early introduction to the trades through job sampling; offer financial incentives; and invest in outreach programs. 4 figs.

  11. Genetic Evidence Highlights Potential Impacts of By-Catch to Cetaceans

    Science.gov (United States)

    Mendez, Martin; Rosenbaum, Howard C.; Wells, Randall S.; Stamper, Andrew; Bordino, Pablo

    2010-01-01

    Incidental entanglement in fishing gear is arguably the most serious threat to many populations of small cetaceans, judging by the alarming number of captured animals. However, other aspects of this threat, such as the potential capture of mother-offspring pairs or reproductive pairs, could be equally or even more significant but have rarely been evaluated. Using a combination of demographic and genetic data we provide evidence that i) Franciscana dolphin pairs that are potentially reproductive and mother-offspring pairs form temporal bonds, and ii) are entangled simultaneously. Our results highlight potential demographic and genetic impacts of by-catch to cetacean populations: the joint entanglement of mother-offspring or reproductive pairs, compared to random individuals, might exacerbate the demographic consequences of by-catch, and the loss of groups of relatives means that significant components of genetic diversity could be lost together. Given the social nature of many odontocetes (toothed cetaceans), we suggest that these potential impacts could be rather general to the group and therefore by-catch could be more detrimental than previously considered. PMID:21179542

  12. Emerging roles for microtubules in angiosperm pollen tube growth highlight new research cues

    Directory of Open Access Journals (Sweden)

    Alessandra eMoscatelli

    2015-02-01

    Full Text Available In plants, actin filaments have an important role in organelle movement and cytoplasmic streaming. Otherwise microtubules have a role in restricting organelles to specific areas of the cell and in maintaining organelle morphology. In somatic plant cells, microtubules also participate in cell division and morphogenesis, allowing cells to take their definitive shape in order to perform specific functions. In the latter case, microtubules influence assembly of the cell wall, controlling the delivery of enzymes involved in cellulose synthesis and of wall modulation material to the proper sites.In angiosperm pollen tubes, organelle movement is generally attributed to the acto-myosin system, the main role of which is in distributing organelles in the cytoplasm and in carrying secretory vesicles to the apex for polarized growth. Recent data on membrane trafficking suggests a role of microtubules in fine delivery and repositioning of vesicles to sustain pollen tube growth. This review examines the role of microtubules in secretion and endocytosis, highlighting new research cues regarding cell wall construction and pollen tube-pistil crosstalk, that help unravel the role of microtubules in polarized growth.

  13. A new dimensionless number highlighted from mechanical energy exchange during running.

    Science.gov (United States)

    Delattre, Nicolas; Moretto, Pierre

    2008-09-18

    This study aimed to highlight a new dimensionless number from mechanical energy transfer occurring at the centre of gravity (Cg) during running. We built two different-sized spring-mass models (SMM #1 and SMM #2). SMM #1 was built from the previously published data, and SMM #2 was built to be dynamically similar to SMM #1. The potential gravitational energy (E(P)), kinetic energy (E(K)), and potential elastic energy (E(E)) were taken into account to test our hypothesis. For both SMM #1 and SMM #2, N(Mo-Dela)=(E(P)+E(K))/E(E) reached the same mean value and was constant (4.1+/-0.7) between 30% and 70% of contact time. Values of N(Mo-Dela) obtained out of this time interval were due to the absence of E(E) at initial and final times of the simulation. This phenomenon does not occur during in vivo running because a leg muscle's pre-activation enables potential elastic energy storage prior to ground contact. Our findings also revealed that two different-sized spring-mass models bouncing with equal N(Mo-Dela) values moved in a dynamically similar fashion. N(Mo-Dela), which can be expressed by the combination of Strouhal and Froude numbers, could be of great interest in order to study animal and human locomotion under Earth's gravity or to induce dynamic similarity between different-sized individuals during bouncing gaits.

  14. On the Need for Rethinking Current Practice that Highlights Goal Achievement Risk in an Enterprise Context.

    Science.gov (United States)

    Aven, Eyvind; Aven, Terje

    2015-09-01

    This article addresses the issue of how performance and risk management can complement each other in order to enhance the management of an enterprise. Often, we see that risk management focuses on goal achievements and not the enterprise risk related to its activities in the value chain. The statement "no goal, no risk" is a common misconception. The main aim of the article is to present a normative model for describing the links between performance and risk, and to use this model to give recommendations on how to best structure and plan the management of an enterprise in situations involving risk and uncertainties. The model, which has several novel features, is based on the interaction between different types of risk management (enterprise risk management, task risk management, and personal risk management) and a structure where the enterprise risk management overrules both the task and personal risk management. To illustrate the model we use the metaphor of a ship, where the ship is loaded with cash-generating activities and has a direction over time determined by the overall strategic objectives. Compared to the current enterprise risk management practice, the model and related analysis are founded on a new perspective on risk, highlighting knowledge and uncertainties beyond probabilities. © 2015 Society for Risk Analysis.

  15. Emotional sensitization highlights the attentional bias in blood-injection-injury phobics: an ERP study.

    Science.gov (United States)

    Sarlo, Michela; Buodo, Giulia; Devigili, Andrea; Munafò, Marianna; Palomba, Daniela

    2011-02-18

    The presence of an attentional bias towards disorder-related stimuli has not been consistently demonstrated in blood phobics. The present study was aimed at investigating whether or not an attentional bias, as measured by event-related potentials (ERPs), could be highlighted in blood phobics by inducing cognitive-emotional sensitization through the repetitive presentation of different disorder-related pictures. The mean amplitudes of the N100, P200, P300 and late positive potentials to picture onset were assessed along with subjective ratings of valence and arousal in 13 blood phobics and 12 healthy controls. Blood phobics, but not controls, showed a linear increase of subjective arousal over time, suggesting that cognitive-emotional sensitization did occur. The analysis of cortical responses showed larger N100 and smaller late positive potentials in phobics than in controls in response to mutilations. These findings suggest that cognitive-emotional sensitization induced an attentional bias in blood phobics during picture viewing, involving early selective encoding and late cognitive avoidance of disorder-related stimuli depicting mutilations. © 2010 Elsevier Ireland Ltd. All rights reserved.

  16. Highlighting continued uncertainty in global land cover maps for the user community

    International Nuclear Information System (INIS)

    Fritz, Steffen; See, Linda; McCallum, Ian; Schill, Christian; Obersteiner, Michael; Van der Velde, Marijn; Boettcher, Hannes; Havlík, Petr; Achard, Frédéric

    2011-01-01

    In the last 10 years a number of new global datasets have been created and new, more sophisticated algorithms have been designed to classify land cover. GlobCover and MODIS v.5 are the most recent global land cover products available, where GlobCover (300 m) has the finest spatial resolution of other comparable products such as MODIS v.5 (500 m) and GLC-2000 (1 km). This letter shows that the thematic accuracy in the cropland domain has decreased when comparing these two latest products. This disagreement is also evident spatially when examining maps of cropland and forest disagreement between GLC-2000, MODIS and GlobCover. The analysis highlights the continued uncertainty surrounding these products, with a combined forest and cropland disagreement of 893 Mha (GlobCover versus MODIS v.5). This letter suggests that data sharing efforts and the provision of more in situ data for training, calibration and validation are very important conditions for improving future global land cover products.

  17. Algal Pretreatment Improves Biofuels Yield and Value; Highlights in Science, NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-05-15

    One of the major challenges associated with algal biofuels production in a biorefinery-type setting is improving biomass utilization in its entirety, increasing the process energetic yields and providing economically viable and scalable co-product concepts. We demonstrate the effectiveness of a novel, integrated technology based on moderate temperatures and low pH to convert the carbohydrates in wet algal biomass to soluble sugars for fermentation, while making lipids more accessible for downstream extraction and leaving a protein-enriched fraction behind. This research has been highlighted in the Green Chemistry journal article mentioned above and a milestone report, and is based on the work the researchers are doing for the AOP projects Algal Biomass Conversion and Algal Biofuels Techno-economic Analysis. That work has demonstrated an advanced process for algal biofuel production that captures the value of both the algal lipids and carbohydrates for conversion to biofuels.  With this process, as much as 150 GGE/ton of biomass can be produced, 2-3X more than can be produced by terrestrial feedstocks.  This can also reduce the cost of biofuel production by as much as 40%. This also represents the first ever design case for the algal lipid upgrading pathway.

  18. Solidarity through shared disadvantage: Highlighting shared experiences of discrimination improves relations between stigmatized groups.

    Science.gov (United States)

    Cortland, Clarissa I; Craig, Maureen A; Shapiro, Jenessa R; Richeson, Jennifer A; Neel, Rebecca; Goldstein, Noah J

    2017-10-01

    Intergroup relations research has largely focused on relations between members of dominant groups and members of disadvantaged groups. The small body of work examining intraminority intergroup relations, or relations between members of different disadvantaged groups, reveals that salient experiences of ingroup discrimination promote positive relations between groups that share a dimension of identity (e.g., 2 different racial minority groups) and negative relations between groups that do not share a dimension of identity (e.g., a racial minority group and a sexual minority group). In the present work, we propose that shared experiences of discrimination between groups that do not share an identity dimension can be used as a lever to facilitate positive intraminority intergroup relations. Five experiments examining relations among 4 different disadvantaged groups supported this hypothesis. Both blatant (Experiments 1 and 3) and subtle (Experiments 2, 3, and 4) connections to shared experiences of discrimination, or inducing a similarity-seeking mindset in the context of discrimination faced by one's ingroup (Experiment 5), increased support for policies benefiting the outgroup (Experiments 1, 2, and 4) and reduced intergroup bias (Experiments 3, 4, and 5). Taken together, these experiments provide converging evidence that highlighting shared experiences of discrimination can improve intergroup outcomes between stigmatized groups across dimensions of social identity. Implications of these findings for intraminority intergroup relations are discussed. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  19. Professor Mansour Ali Haseeb: Highlights from a pioneer of biomedical research, physician and scientist.

    Science.gov (United States)

    Salih, Mustafa Abdalla M

    2013-01-01

    The article highlights the career of Professor Mansour Ali Haseeb (1910 - 1973; DKSM, Dip Bact, FRCPath, FRCP [Lond]), a pioneer worker in health, medical services, biomedical research and medical education in the Sudan. After his graduation from the Kitchener School of Medicine (renamed, Faculty of Medicine, University of Khartoum [U of K]) in 1934, he devoted his life for the development of laboratory medicine. He became the first Sudanese Director of Stack Medical Research Laboratories (1952 - 1962). He made valuable contributions by his services in the vaccine production and implementation programs, most notably in combating small pox, rabies and epidemic meningitis. In 1963 he became the first Sudanese Professor of Microbiology and Parasitology and served as the first Sudanese Dean of the Faculty of Medicine, U of K (1963-1969). He was an active loyal citizen in public life and served in various fields outside the medical profession. As Mayor of Omdurman, he was invited to visit Berlin in 1963 by Willy Brandt, Mayor of West Berlin (1957-1966) and Chancellor of the Federal Republic of Germany (1969 to 1974). Also as Mayor of Omdurman, he represented the City in welcoming Queen Elizabeth II during her visit to Sudan in February 1965. He also received State Medals from Egypt and Ethiopia. In 1973 he was appointed Chairman of the Sudan Medical Research Council, and was awarded the international Dr. Shousha Foundation Prize and Medal by the WHO for his contribution in the advancement of health, research and medical services.

  20. Personal reflections on the highlights and changes in radiation and radioisotope measurement applications

    International Nuclear Information System (INIS)

    Gardner, Robin P.; Lee, Kyoung O.

    2015-01-01

    This paper describes the recent changes that the authors have perceived in the use of radiation and radioisotope measurement applications. The first change is that due to the increased use of Monte Carlo simulation which has occurred from a normal evolutionary process. This is due in large part to the increased accuracy that is being obtained by the use of detector response functions (DRFs) and the simultaneous increased computational efficiency that has become available with these DRFs, the availability of a greatly improved weight windows variance reduction method, and the availability of inexpensive computer clusters. This first change is a happy one. The other change that is occurring is in response to recent terrorist activities. That change is the replacement or major change in the use of long-lived radioisotopes in radioisotope measurement and other radioisotope source applications. In general this can be done by improving the security of these radioisotope sources or by replacing them altogether by using machine sources of radiation. In either case one would like to preclude altogether or at least minimize the possibility of terrorists being able to obtain radioisotopes and use them for clandestine purposes. - Highlights: • Recent changes in radioisotope measurement applications. • Improvements in Monte Carlo simulation for treating radioisotope measurement applications. • Replacement of radioisotope sources with machine sources of radiation.

  1. A vaccine cold chain freezing study in PNG highlights technology needs for hot climate countries.

    Science.gov (United States)

    Wirkas, Theo; Toikilik, Steven; Miller, Nan; Morgan, Chris; Clements, C John

    2007-01-08

    Fourteen data loggers were packed with vaccine vials at the national vaccine store, Port Moresby, Papua New Guinea (PNG), and sent to peripheral locations in the health system. The temperatures that the data loggers recorded during their passage along the cold chain indicated that heat damage was unlikely, but that all vials were exposed to freezing temperatures at some time. The commonest place where freezing conditions existed was during transport. The freezing conditions were likely induced by packing the vials too close to the ice packs that were themselves too cold, and with insufficient insulation between them. This situation was rectified and a repeat dispatch of data loggers demonstrated that the system had indeed been rectified. Avoiding freeze damage becomes even more important as the price of freeze-sensitive vaccines increases with the introduction of more multiple-antigen vaccines. This low-cost high-tech method of evaluating the cold chain function is highly recommended for developing and industrialized nations and should be used on a regular basis to check the integrity of the vaccine cold chain. The study highlights the need for technological solutions to avoid vaccine freezing, particularly in hot climate countries.

  2. Liposome Delivery Systems for Inhalation: A Critical Review Highlighting Formulation Issues and Anticancer Applications.

    Science.gov (United States)

    Rudokas, Mindaugas; Najlah, Mohammad; Alhnan, Mohamed Albed; Elhissi, Abdelbary

    2016-01-01

    This is a critical review on research conducted in the field of pulmonary delivery of liposomes. Issues relating to the mechanism of nebulisation and liposome composition were appraised and correlated with literature reports of liposome formulations used in clinical trials to understand the role of liposome size and composition on therapeutic outcome. A major highlight was liposome inhalation for the treatment of lung cancers. Many in vivo studies that explored the potential of liposomes as anticancer carrier systems were evaluated, including animal studies and clinical trials. Liposomes can entrap anticancer drugs and localise their action in the lung following pulmonary delivery. The safety of inhaled liposomes incorporating anticancer drugs depends on the anticancer agent used and the amount of drug delivered to the target cancer in the lung. The difficulty of efficient targeting of liposomal anticancer aerosols to the cancerous tissues within the lung may result in low doses reaching the target site. Overall, following the success of liposomes as inhalable carriers in the treatment of lung infections, it is expected that more focus from research and development will be given to designing inhalable liposome carriers for the treatment of other lung diseases, including pulmonary cancers. The successful development of anticancer liposomes for inhalation may depend on the future development of effective aerosolisation devices and better targeted liposomes to maximise the benefit of therapy and reduce the potential for local and systemic adverse effects. © 2016 S. Karger AG, Basel.

  3. Activity in the superior temporal sulcus highlights learning competence in an interaction game.

    Science.gov (United States)

    Haruno, Masahiko; Kawato, Mitsuo

    2009-04-08

    During behavioral adaptation through interaction with human and nonhuman agents, marked individual differences are seen in both real-life situations and games. However, the underlying neural mechanism is not well understood. We conducted a neuroimaging experiment in which subjects maximized monetary rewards by learning in a prisoner's dilemma game with two computer agents: agent A, a tit-for-tat player who repeats the subject's previous action, and agent B, a simple stochastic cooperator oblivious to the subject's action. Approximately 1/3 of the subjects (group I) learned optimally in relation to both A and B, while another 1/3 (group II) did so only for B. Post-experiment interviews indicated that group I exploited the agent strategies more often than group II. Significant differences in learning-related brain activity between the two groups were only found in the superior temporal sulcus (STS) for both A and B. Furthermore, the learning performance of each group I subject was predictable based on this STS activity, but not in the group II subjects. This differential activity could not be attributed to a behavioral difference since it persisted in relation to agent B for which the two groups behaved similarly. In sharp contrast, the brain structures for reward processing were recruited similarly by both groups. These results suggest that STS provides knowledge of the other agent's strategies for association between action and reward and highlights learning competence during interactive reinforcement learning.

  4. Hanford Site Permanent Isolation Surface Barrier Development Program: Fiscal year 1992 and 1993 highlights

    International Nuclear Information System (INIS)

    Cadwell, L.L.; Link, S.O.; Gee, G.W.

    1993-09-01

    The Hanford Site Permanent Isolation Surface Barrier Development Program was jointly developed by the Pacific Northwest Laboratory and Westinghouse Hanford Company to design and test an earthen cover system that can be used to inhibit water infiltration; plant, animal, and human intrusion; and wind and water erosion. Kaiser Engineers Hanford Company provided engineering design support for the program. Work on barrier design has been under way at Hanford for nearly 10 years. The comprehensive development of a long-term barrier, formerly the Hanford Site Protective Barrier Development Program, was initiated in FY 1986, and a general field-tested design is expected to be completed by FY 1998. Highlights of efforts in FY 1992 and FY 1993 included the resumption of field testing, the completion of the prototype barrier design, and the convening of an external peer review panel, which met twice with the barrier development team. The review panel provided helpful guidance on current and future barrier development activities, while commending the program for its significant technical contributions to innovative barrier technology development

  5. Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.

    Science.gov (United States)

    Smith, Rosanna C G; Stumpf, Patrick S; Ridden, Sonya J; Sim, Aaron; Filippi, Sarah; Harrington, Heather A; MacArthur, Ben D

    2017-06-20

    A number of important pluripotency regulators, including the transcription factor Nanog, are observed to fluctuate stochastically in individual embryonic stem cells. By transiently priming cells for commitment to different lineages, these fluctuations are thought to be important to the maintenance of, and exit from, pluripotency. However, because temporal changes in intracellular protein abundances cannot be measured directly in live cells, fluctuations are typically assessed using genetically engineered reporter cell lines that produce a fluorescent signal as a proxy for protein expression. Here, using a combination of mathematical modeling and experiment, we show that there are unforeseen ways in which widely used reporter strategies can systematically disturb the dynamics they are intended to monitor, sometimes giving profoundly misleading results. In the case of Nanog, we show how genetic reporters can compromise the behavior of important pluripotency-sustaining positive feedback loops, and induce a bifurcation in the underlying dynamics that gives rise to heterogeneous Nanog expression patterns in reporter cell lines that are not representative of the wild-type. These findings help explain the range of published observations of Nanog variability and highlight the problem of measurement in live cells. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  6. Hanford Site Long-term Surface Barrier Development Program: Fiscal year 1994 highlights

    International Nuclear Information System (INIS)

    Petersen, K.L.; Link, S.O.; Gee, G.W.

    1995-08-01

    The Hanford Site Surface Barrier Development Program was organized in 1985 to test the effectiveness of various barrier designs in minimizing the effects of water infiltration; plant, animal and human intrusion; and wind and water erosion on buried wastes, plus preventing or minimizing the emanation of noxious gases. A team of scientists from the Pacific Northwest Laboratory (PNL) and engineers from Westinghouse Hanford Company (WHC) direct the barrier development effort. ICF Kaiser Hanford Company, in conjunction with WHC and PNL, developed design drawings and construction specifications for a 5-acre prototype barrier. The highlight of efforts in FY 1994 was the construction of the prototype barrier. The prototype barrier was constructed on the Hanford Site at the 200 BP-1 Operable Unit of the 200 East Area. Construction was completed in August 1994 and monitoring instruments are being installed so experiments on the prototype barrier can begin in FY 1995. The purpose of the prototype barrier is to provide insights and experience with issues regarding barrier design, construction, and performance that have not been possible with individual tests and experiments conducted to date. Additional knowledge and experience was gained in FY 1994 on erosion control, physical stability, water infiltration control, model testing, Resource Conservation and Recovery Act (RCRA) comparisons, biointrusion control, long-term performance, and technology transfer

  7. Highlights from the First Ever Demographic Study of Solar Physics, Space Physics, and Upper Atmospheric Physics

    Science.gov (United States)

    Moldwin, M.; Morrow, C. A.; White, S. C.; Ivie, R.

    2014-12-01

    Members of the Education & Workforce Working Group and the American Institute of Physics (AIP) conducted the first ever National Demographic Survey of working professionals for the 2012 National Academy of Sciences Solar and Space Physics Decadal Survey to learn about the demographics of this sub-field of space science. The instrument contained questions for participants on: the type of workplace; basic demographic information regarding gender and minority status, educational pathways (discipline of undergrad degree, field of their PhD), how their undergraduate and graduate student researchers are funded, participation in NSF and NASA funded spaceflight missions and suborbital programs, and barriers to career advancement. Using contact data bases from AGU, the American Astronomical Society's Solar Physics Division (AAS-SPD), attendees of NOAA's Space Weather Week and proposal submissions to NSF's Atmospheric, Geospace Science Division, the AIP's Statistical Research Center cross correlated and culled these data bases resulting in 2776 unique email addresses of US based working professionals. The survey received 1305 responses (51%) and generated 125 pages of single space answers to a number of open-ended questions. This talk will summarize the highlights of this first-ever demographic survey including findings extracted from the open-ended responses regarding barriers to career advancement which showed significant gender differences.

  8. Educational Entrepreneurship (EE: Delineating and Highlighting Its Domain, Importance and Feasibility in Uganda’s Context

    Directory of Open Access Journals (Sweden)

    Genza Musoke Gyaviira

    2018-02-01

    Full Text Available Although in many countries government financial support for education is dwindling, not many educational institutions have succeeded in devising internal mechanisms and practices to enable them to continuously deliver quality education in quantity. Might the application of certain entrepreneurial strategies in educational management perhaps help to make a difference? What is educational entrepreneurship (EE? How feasible is EE in a developing world education landscape like that of Uganda? Which challenges must EE surmount before it can envisage success? Using literature review methodology, this study attempted to find answers to such questions. Its aim was to delineate the EE domain and to highlight both its importance and feasibility in Uganda’s context. The study makes two important revelations; first, that indeed EE is clouded in conceptual mishmash, hence need for more scholarly attention on the subject; second, that however salvaging EE can be to struggling educational institutions, it is not without challenges – even apparent contradictions – hence preference for a “moderate risk” approach to entrepreneurship within educational institutions.    

  9. Where there's a will: can highlighting future youth-targeted marketing increase support for soda taxes?

    Science.gov (United States)

    Roh, Sungjong; Schuldt, Jonathon P

    2014-12-01

    Amid concern about high rates of obesity and related diseases, the marketing of nutritionally poor foods to young people by the food industry has come under heavy criticism by public health advocates, who cite decades of youth-targeted marketing in arguing for reforms. In light of recent evidence that the same event evokes stronger emotional reactions when it occurs in the future versus the past, highlighting youth-targeted marketing that has yet to occur may evoke stronger reactions to such practices, and perhaps, greater support for related health policy initiatives. In a between-subjects experiment, Web participants (N = 285) read that a major soda company had already launched (past condition) or was planning to launch (future condition) an advertising campaign targeting children. Measures included support for a soda tax and affective responses to the company's actions. Greater support for the soda tax was observed in the future condition than in the past condition. Moreover, participants in the future condition reported heightened negative emotions about the company's actions, which mediated the observed effect on soda tax support. The same action undertaken by the food industry (here, marketing soda to children) may evoke stronger negative emotions and greater support for a health policy initiative when it is framed prospectively rather than retrospectively.

  10. A preliminary molecular phylogeny of shield-bearer moths (Lepidoptera: Adeloidea: Heliozelidae) highlights rich undescribed diversity.

    Science.gov (United States)

    Milla, Liz; van Nieukerken, Erik J; Vijverberg, Ruben; Doorenweerd, Camiel; Wilcox, Stephen A; Halsey, Mike; Young, David A; Jones, Therésa M; Kallies, Axel; Hilton, Douglas J

    2018-03-01

    Heliozelidae are a widespread, evolutionarily early diverging family of small, day-flying monotrysian moths, for which a comprehensive phylogeny is lacking. We generated the first molecular phylogeny of the family using DNA sequences of two mitochondrial genes (COI and COII) and two nuclear genes (H3 and 28S) from 130 Heliozelidae specimens, including eight of the twelve known genera: Antispila, Antispilina, Coptodisca, Heliozela, Holocacista, Hoplophanes, Pseliastis, and Tyriozela. Our results provide strong support for five major Heliozelidae clades: (i) a large widespread clade containing the leaf-mining genera Antispilina, Coptodisca and Holocacista and some species of Antispila, (ii) a clade containing most of the described Antispila, (iii) a clade containing the leaf-mining genus Heliozela and the monotypic genus Tyriozela, (iv) an Australian clade containing Pseliastis and (v) an Australian clade containing Hoplophanes. Each clade includes several new species and potentially new genera. Collectively, our data uncover a rich and undescribed diversity that appears to be especially prevalent in Australia. Our work highlights the need for a major taxonomic revision of the family and for generating a robust molecular phylogeny using multi-gene approaches in order to resolve the relationships among clades. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  11. HIVR4P 2016, Partnering for Prevention: Conference Summary and Highlights.

    Science.gov (United States)

    Shacklett, Barbara L; Derdeyn, Cynthia A; Folayan, Morenike Oluwatoyin; Landovitz, Raphael J; Anthony, Colin; Behrens, Anna-Janina; Hope, Thomas J; Landais, Elise; Leal, Lorna; Marrazzo, Jeanne M; Morris, Lynn; Mugo, Nelly; Ngure, Kenneth; Noseda, Veronica; Ranasinghe, Srinika; Tully, Damien C; Voronin, Yegor; Warren, Mitchell; Wibmer, Constantinos Kurt; Xie, Irene Y; Scarlatti, Gabriella; Thyagarajan, Bargavi

    2017-08-01

    HIV Research for Prevention: AIDS Vaccine, Microbicide, and ARV-based Prevention Science (HIVR4P) was built on a growing consensus that effective HIV prevention requires a combination of approaches and that understanding, analyzing, and debating the cross-cutting issues that impact prevention research are all essential to combat the global HIV/AIDS epidemic. To that end, the biennial HIVR4P conference is dedicated to all biomedical HIV prevention research approaches, including HIV vaccines, microbicides, pre-exposure prophylaxis, and treatment as prevention. The HIVR4P 2016 conference was held in Chicago, Illinois (USA), on October 17-21, and included more than 700 scientific presentations and 21 satellite sessions covering the latest and most promising advances across the HIV prevention research field. The theme "Partnering for Prevention" represented the conference's commitment to breaking down silos between research disciplines as well as between researchers, program developers, care providers, advocates, communities, and funders. Delegates spanning 42 countries attended the conference. One-third of those in attendance were early career investigators, which reflects a firm commitment to emerging researchers and ultimately to the goal of developing a sustainable scientific enterprise well into the future. This article presents a concise summary of highlights from the conference. For a more detailed account, one may find full abstracts, daily summaries, and webcasts on the conference website at hivr4p.org.

  12. Status of SINQ, the only MW spallation neutron source-highlighting target development and industrial applications

    International Nuclear Information System (INIS)

    Wagner, Werner; Dai, Yong; Glasbrenner, Heike; Grosse, Mirco; Lehmann, Eberhard

    2006-01-01

    SINQ is a continuous spallation neutron source, driven by PSI's 590 MeV proton accelerator. Receiving a stable proton current of 1.3 mA, SINQ is the presently most powerful accelerator-driven facility worldwide. Besides the primary designation of SINQ to serve as user facility for neutron scattering and neutron imaging, PSI seeks to play a leading role in the development of the facility, focusing on spallation targets and materials research for high-dose radiation environments. Accompanying these activities, SINQ has established several projects serving a more general, profound development towards high-power spallation targets: the most prominent ones being SINQ Target Irradiation Program (STIP) and megawatt pilot experiment for a liquid metal target (MEGAPIE), complemented by LiSoR and VIMOS. Within the user program, SINQ is aspiring to attract an appropriate contingent of industrial applications. The paper highlights the potential for industrial applications by means of selected examples from strain mapping and neutron imaging

  13. MALDI-TOF typing highlights geographical and fluconazole resistance clusters in Candida glabrata.

    Science.gov (United States)

    Dhieb, C; Normand, A C; Al-Yasiri, M; Chaker, E; El Euch, D; Vranckx, K; Hendrickx, M; Sadfi, N; Piarroux, R; Ranque, S

    2015-06-01

    Utilizing matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectra for Candida glabrata typing would be a cost-effective and easy-to-use alternative to classical DNA-based typing methods. This study aimed to use MALDI-TOF for the typing of C. glabrata clinical isolates from various geographical origins and test its capacity to differentiate between fluconazole-sensitive and -resistant strains.Both microsatellite length polymorphism (MLP) and MALDI-TOF mass spectra of 58 C. glabrata isolates originating from Marseilles (France) and Tunis (Tunisia) as well as collection strains from diverse geographic origins were analyzed. The same analysis was conducted on a subset of C. glabrata isolates that were either susceptible (MIC ≤ 8 mg/l) or resistant (MIC ≥ 64 mg/l) to fluconazole.According to the seminal results, both MALDI-TOF and MLP classifications could highlight C. glabrata population structures associated with either geographical dispersal barriers (p typing to investigate C. glabrata infection outbreaks and predict the antifungal susceptibility profile of clinical laboratory isolates. © The Author 2015. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  14. Brain Potentials Highlight Stronger Implicit Food Memory for Taste than Health and Context Associations.

    Science.gov (United States)

    Hoogeveen, Heleen R; Jolij, Jacob; Ter Horst, Gert J; Lorist, Monicque M

    2016-01-01

    Increasingly consumption of healthy foods is advised to improve population health. Reasons people give for choosing one food over another suggest that non-sensory features like health aspects are appreciated as of lower importance than taste. However, many food choices are made in the absence of the actual perception of a food's sensory properties, and therefore highly rely on previous experiences of similar consumptions stored in memory. In this study we assessed the differential strength of food associations implicitly stored in memory, using an associative priming paradigm. Participants (N = 30) were exposed to a forced-choice picture-categorization task, in which the food or non-food target images were primed with either non-sensory or sensory related words. We observed a smaller N400 amplitude at the parietal electrodes when categorizing food as compared to non-food images. While this effect was enhanced by the presentation of a food-related word prime during food trials, the primes had no effect in the non-food trials. More specifically, we found that sensory associations are stronger implicitly represented in memory as compared to non-sensory associations. Thus, this study highlights the neuronal mechanisms underlying previous observations that sensory associations are important features of food memory, and therefore a primary motive in food choice.

  15. OSART programme highlights 1993-1994. Operational safety practices in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    This report continues the practice of summarizing mission results so that all the aspects of OSART missions, Pre-OSART missions and good practices are to be found in one volume. For the first time it includes results of follow-up visits. Attempts have been made in this report to highlight the most significant findings whilst retaining as much of the vital background information as possible. This report is in four parts: Part I summarizes the most significant observations made during the missions and follow-up visits during 1993-1994; Part II, in chronological order, is an overview of the major strengths and opportunities for improvement identified during each OSART mission and summaries of follow-up visits performed during the period; Part III lists good practices that were identified during 1993 and 1994; and Part IV presents the recently developed OSART mission results (OSMIR) database. Each part of the report is intended for different levels in operating and regulatory organizations but not exclusively so. Part I is primarily to the executive management level; Part II to middle managers; and Parts III and IV to those involved in operational experience feedback. Because of widely different plant designs, operating and management styles, cultural practices, and other factors affecting plant operations, no OSART findings were applicable to all of the plants visited in 1993 and 1994. Individual findings varied considerably in scope and significance. However, the findings do reflect some common strengths and opportunities for improvement. 4 tabs.

  16. Silver linings on the horizon: highlights from the 10th Cachexia Conference.

    Science.gov (United States)

    Ebner, Nicole; von Haehling, Stephan

    2018-02-01

    This article highlights the updates from preclinical and clinical studies into the field of wasting disorders that were presented at the 10th Cachexia Conference held in Rome, Italy, in December 2017. This year's conference saw some interesting results of larger-scale studies and clinical trials and new therapeutic targets. Herein, we summarize the biological and clinical significance of different markers and new diagnostic tools and cut-offs for the detection of skeletal muscle wasting, including micro RNAs, the ubiquitin-proteasome system, mTOR signalling, news in body composition analysis including the D3-creatine dilution method, and new biomarkers. Clinical studies investigated novel nutritional approaches, trials of elamipretide, enobosarm, and urolithin A. It remains a fact, however, that effective treatments of cachexia and wasting disorders are urgently needed in order to improve patients' quality of life and their survival. © 2018 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders.

  17. The Third International Genomic Medicine Conference (3rd IGMC, 2015: overall activities and outcome highlights

    Directory of Open Access Journals (Sweden)

    Muhammad Abu-Elmagd

    2016-10-01

    Full Text Available Abstract The Third International Genomic Medicine Conference (3rd IGMC was organised by the Centre of Excellence in Genomic Medicine Research (CEGMR at the King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia (KSA. This conference is a continuation of a series of meetings, which began with the first International Genomic Medicine Conference (1st IGMC, 2011 followed by the second International Genomic Medicine Conference (2nd IGMC, 2013. The 3rd IGMC meeting presented as a timely opportunity to bring scientists from across the world to gather, discuss, and exchange recent advances in the field of genomics and genetics in general as well as practical information on using these new technologies in different basic and clinical applications. The meeting undoubtedly inspired young male and female Saudi researchers, who attended the conference in large numbers, as evidenced by the oversubscribed oral and poster presentations. The conference also witnessed the launch of the first content for npj Genomic Medicine, a high quality new journal was established in partnership by CEGMR with Springer Nature and published as part of the Nature Partner Journal series. Here, we present a brief summary report of the 2-day meeting including highlights from the oral presentations, poster presentations, workshops, poster prize-winners and comments from the distinguished scientists.

  18. Quantitative Analysis of Signaling Networks across Differentially Embedded Tumors Highlights Interpatient Heterogeneity in Human Glioblastoma

    Science.gov (United States)

    2015-01-01

    Glioblastoma multiforme (GBM) is the most aggressive malignant primary brain tumor, with a dismal mean survival even with the current standard of care. Although in vitro cell systems can provide mechanistic insight into the regulatory networks governing GBM cell proliferation and migration, clinical samples provide a more physiologically relevant view of oncogenic signaling networks. However, clinical samples are not widely available and may be embedded for histopathologic analysis. With the goal of accurately identifying activated signaling networks in GBM tumor samples, we investigated the impact of embedding in optimal cutting temperature (OCT) compound followed by flash freezing in LN2 vs immediate flash freezing (iFF) in LN2 on protein expression and phosphorylation-mediated signaling networks. Quantitative proteomic and phosphoproteomic analysis of 8 pairs of tumor specimens revealed minimal impact of the different sample processing strategies and highlighted the large interpatient heterogeneity present in these tumors. Correlation analyses of the differentially processed tumor sections identified activated signaling networks present in selected tumors and revealed the differential expression of transcription, translation, and degradation associated proteins. This study demonstrates the capability of quantitative mass spectrometry for identification of in vivo oncogenic signaling networks from human tumor specimens that were either OCT-embedded or immediately flash-frozen. PMID:24927040

  19. Duplications and losses in gene families of rust pathogens highlight putative effectors

    Directory of Open Access Journals (Sweden)

    Amanda L. Pendleton

    2014-06-01

    Full Text Available Rust fungi are a group of fungal pathogens that cause some of the world’s most destructive diseases of trees and crops. A shared characteristic among rust fungi is obligate biotrophy, the inability to complete a lifecycle without a host. This dependence on a host species likely affects patterns of gene expansion, contraction, and innovation within rust pathogen genomes. The establishment of disease by biotrophic pathogens is reliant upon effector proteins that are encoded in the fungal genome and secreted from the pathogen into the host’s cell apoplast or within the cells. This study uses a comparative genomic approach to elucidate putative effectors and determine their evolutionary histories. We used OrthoMCL to identify nearly 20,000 gene families in proteomes of sixteen diverse fungal species, which include fifteen basidiomycetes and one ascomycete. We inferred patterns of duplication and loss for each gene family and identified families with distinctive patterns of expansion/contraction associated with the evolution of rust fungal genomes. To recognize potential contributors for the unique features of rust pathogens, we identified families harboring secreted proteins that: i arose or expanded in rust pathogens relative to other fungi, or ii contracted or were lost in rust fungal genomes. While the origin of rust fungi appears to be associated with considerable gene loss, there are many gene duplications associated with each sampled rust fungal genome. We also highlight two putative effector gene families that have expanded in Cqf that we hypothesize have roles in pathogenicity.

  20. Genomes of coral dinoflagellate symbionts highlight evolutionary adaptations conducive to a symbiotic lifestyle

    KAUST Repository

    Aranda, Manuel

    2016-12-22

    Despite half a century of research, the biology of dinoflagellates remains enigmatic: they defy many functional and genetic traits attributed to typical eukaryotic cells. Genomic approaches to study dinoflagellates are often stymied due to their large, multi-gigabase genomes. Members of the genus Symbiodinium are photosynthetic endosymbionts of stony corals that provide the foundation of coral reef ecosystems. Their smaller genome sizes provide an opportunity to interrogate evolution and functionality of dinoflagellate genomes and endosymbiosis. We sequenced the genome of the ancestral Symbiodinium microadriaticum and compared it to the genomes of the more derived Symbiodinium minutum and Symbiodinium kawagutii and eukaryote model systems as well as transcriptomes from other dinoflagellates. Comparative analyses of genome and transcriptome protein sets show that all dinoflagellates, not only Symbiodinium, possess significantly more transmembrane transporters involved in the exchange of amino acids, lipids, and glycerol than other eukaryotes. Importantly, we find that only Symbiodinium harbor an extensive transporter repertoire associated with the provisioning of carbon and nitrogen. Analyses of these transporters show species-specific expansions, which provides a genomic basis to explain differential compatibilities to an array of hosts and environments, and highlights the putative importance of gene duplications as an evolutionary mechanism in dinoflagellates and Symbiodinium.

  1. Local and regional smokefree and tobacco-free action in New Zealand: highlights and directions.

    Science.gov (United States)

    Thomson, George; Wilson, Nick

    2017-09-22

    In this viewpoint we highlight and discuss some recent local and regional level advances in tobacco control in Aotearoa/New Zealand. In this country a wide range of local actors are helping drive smokefree and tobacco-free policies, with an increasing presence of businesses in this field. There has been progress in the areas of smokefree dining, large outdoor worksites and ski fields, and parts of downtown areas such as squares and streets. In 2015 and 2016, three councils (Palmerston North, Napier and Hastings) have used pavement lease policies and bylaws to start introducing an element of requirement into smokefree outdoor dining. Elsewhere (eg, Rotorua, Ashburton, Westland and Christchurch) significant smokefree outdoor dining moves have been made by, or in conjunction with, local councils. Tobacco-free retailing continues to expand, particularly in Northland. In the absence of meaningful central government action on smokefree places in the last decade (despite the Smokefree 2025 goal), local activity is leading the way. It is particularly important in providing models for smokefree outdoor hospitality areas, where smoking normalisation and relapse are significant health risks. Nevertheless, there is a need for the local smokefree and tobacco-free activity to be nationally evaluated, particularly for assessing the prevalence of smoking in areas covered by 'smokefree' policies. Action by central government could help local actors by providing a more definite legislative basis for bylaws, by minimum outdoor smokefree laws and by the funding of effective tobacco control mass media.

  2. Genomes of coral dinoflagellate symbionts highlight evolutionary adaptations conducive to a symbiotic lifestyle

    KAUST Repository

    Aranda, Manuel; Li, Yangyang; Liew, Yi Jin; Baumgarten, Sebastian; Simakov, O.; Wilson, M. C.; Piel, J.; Ashoor, Haitham; Bougouffa, Salim; Bajic, Vladimir B.; Ryu, Tae Woo; Ravasi, Timothy; Bayer, Till; Micklem, G.; Kim, H.; Bhak, J.; LaJeunesse, T. C.; Voolstra, Christian R.

    2016-01-01

    Despite half a century of research, the biology of dinoflagellates remains enigmatic: they defy many functional and genetic traits attributed to typical eukaryotic cells. Genomic approaches to study dinoflagellates are often stymied due to their large, multi-gigabase genomes. Members of the genus Symbiodinium are photosynthetic endosymbionts of stony corals that provide the foundation of coral reef ecosystems. Their smaller genome sizes provide an opportunity to interrogate evolution and functionality of dinoflagellate genomes and endosymbiosis. We sequenced the genome of the ancestral Symbiodinium microadriaticum and compared it to the genomes of the more derived Symbiodinium minutum and Symbiodinium kawagutii and eukaryote model systems as well as transcriptomes from other dinoflagellates. Comparative analyses of genome and transcriptome protein sets show that all dinoflagellates, not only Symbiodinium, possess significantly more transmembrane transporters involved in the exchange of amino acids, lipids, and glycerol than other eukaryotes. Importantly, we find that only Symbiodinium harbor an extensive transporter repertoire associated with the provisioning of carbon and nitrogen. Analyses of these transporters show species-specific expansions, which provides a genomic basis to explain differential compatibilities to an array of hosts and environments, and highlights the putative importance of gene duplications as an evolutionary mechanism in dinoflagellates and Symbiodinium.

  3. DNA and dispersal models highlight constrained connectivity in a migratory marine megavertebrate

    Science.gov (United States)

    Naro-Maciel, Eugenia; Hart, Kristen M.; Cruciata, Rossana; Putman, Nathan F.

    2016-01-01

    Population structure and spatial distribution are fundamentally important fields within ecology, evolution, and conservation biology. To investigate pan-Atlantic connectivity of globally endangered green turtles (Chelonia mydas) from two National Parks in Florida, USA, we applied a multidisciplinary approach comparing genetic analysis and ocean circulation modeling. The Everglades (EP) is a juvenile feeding ground, whereas the Dry Tortugas (DT) is used for courtship, breeding, and feeding by adults and juveniles. We sequenced two mitochondrial segments from 138 turtles sampled there from 2006-2015, and simulated oceanic transport to estimate their origins. Genetic and ocean connectivity data revealed northwestern Atlantic rookeries as the major natal sources, while southern and eastern Atlantic contributions were negligible. However, specific rookery estimates differed between genetic and ocean transport models. The combined analyses suggest that post-hatchling drift via ocean currents poorly explains the distribution of neritic juveniles and adults, but juvenile natal homing and population history likely play important roles. DT and EP were genetically similar to feeding grounds along the southern US coast, but highly differentiated from most other Atlantic groups. Despite expanded mitogenomic analysis and correspondingly increased ability to detect genetic variation, no significant differentiation between DT and EP, or among years, sexes or stages was observed. This first genetic analysis of a North Atlantic green turtle courtship area provides rare data supporting local movements and male philopatry. The study highlights the applications of multidisciplinary approaches for ecological research and conservation.

  4. Promoting positive youth development and highlighting reasons for living in Northwest Alaska through digital storytelling.

    Science.gov (United States)

    Wexler, Lisa; Gubrium, Aline; Griffin, Megan; DiFulvio, Gloria

    2013-07-01

    Using a positive youth development framework, this article describes how a 3-year digital storytelling project and the 566 digital stories produced from it in Northwest Alaska promote protective factors in the lives of Alaska Native youth and serve as digital "hope kits," a suicide prevention approach that emphasizes young people's reasons for living. Digital stories are short, participant-produced videos that combine photos, music, and voice. We present process data that indicate the ways that digital stories serve as a platform for youth to reflect on and represent their lives, important relationships and achievements. In so doing, youth use the digital storytelling process to identify and highlight encouraging aspects of their lives, and develop more certain and positive identity formations. These processes are correlated with positive youth health outcomes. In addition, the digital stories themselves serve as reminders of the young people's personal assets--their reasons for living--after the workshop ends. Young people in this project often showed their digital stories to those who were featured positively within as a way to strengthen these interpersonal relationships. Evaluation data from the project show that digital storytelling workshops and outputs are a promising positive youth development approach. The project and the qualitative data demonstrate the need for further studies focusing on outcomes related to suicide prevention.

  5. Duplications and losses in gene families of rust pathogens highlight putative effectors.

    Science.gov (United States)

    Pendleton, Amanda L; Smith, Katherine E; Feau, Nicolas; Martin, Francis M; Grigoriev, Igor V; Hamelin, Richard; Nelson, C Dana; Burleigh, J Gordon; Davis, John M

    2014-01-01

    Rust fungi are a group of fungal pathogens that cause some of the world's most destructive diseases of trees and crops. A shared characteristic among rust fungi is obligate biotrophy, the inability to complete a lifecycle without a host. This dependence on a host species likely affects patterns of gene expansion, contraction, and innovation within rust pathogen genomes. The establishment of disease by biotrophic pathogens is reliant upon effector proteins that are encoded in the fungal genome and secreted from the pathogen into the host's cell apoplast or within the cells. This study uses a comparative genomic approach to elucidate putative effectors and determine their evolutionary histories. We used OrthoMCL to identify nearly 20,000 gene families in proteomes of 16 diverse fungal species, which include 15 basidiomycetes and one ascomycete. We inferred patterns of duplication and loss for each gene family and identified families with distinctive patterns of expansion/contraction associated with the evolution of rust fungal genomes. To recognize potential contributors for the unique features of rust pathogens, we identified families harboring secreted proteins that: (i) arose or expanded in rust pathogens relative to other fungi, or (ii) contracted or were lost in rust fungal genomes. While the origin of rust fungi appears to be associated with considerable gene loss, there are many gene duplications associated with each sampled rust fungal genome. We also highlight two putative effector gene families that have expanded in Cqf that we hypothesize have roles in pathogenicity.

  6. Recent highlights of experimental research for inhibiting tumor growth by using Chinese medicine.

    Science.gov (United States)

    He, Xi-ran; Han, Shu-yan; Li, Ping-ping

    2015-10-01

    To give an overview of contemporary experimental research using Chinese medicine (CM) for the treatment of cancer. As an integral part of mainstream medicine in the People's Republic of China, CM emphasizes improvements in holistic physical condition instead of merely killing tumor cells, which is consistent with the current medical model that advocates patient-oriented treatment. Great progress has been made in experimental research, and the principle aspects include anti-tumor angiogenesis, inducing apoptosis and differentiation, reversing multidrug resistance, and improving immune function. As a current hot topic in cancer research, tumor microenvironment (TME) highlights the mutual and interdependent interaction between tumor cells and their surrounding tissues, and the CM treatment concept bears a striking resemblance to it. To date, primary points of TME include extracellular matrix remodeling, inflammation, hypoxia, and angiogenesis, but trials using CM with a focus on TME are rare. Despite considerable recent development, experimental research on CM for solving cancer issues appears insufficient. Greater efforts in this field are urgently needed.

  7. OSART programme highlights 1993-1994. Operational safety practices in nuclear power plants

    International Nuclear Information System (INIS)

    1996-04-01

    This report continues the practice of summarizing mission results so that all the aspects of OSART missions, Pre-OSART missions and good practices are to be found in one volume. For the first time it includes results of follow-up visits. Attempts have been made in this report to highlight the most significant findings whilst retaining as much of the vital background information as possible. This report is in four parts: Part I summarizes the most significant observations made during the missions and follow-up visits during 1993-1994; Part II, in chronological order, is an overview of the major strengths and opportunities for improvement identified during each OSART mission and summaries of follow-up visits performed during the period; Part III lists good practices that were identified during 1993 and 1994; and Part IV presents the recently developed OSART mission results (OSMIR) database. Each part of the report is intended for different levels in operating and regulatory organizations but not exclusively so. Part I is primarily to the executive management level; Part II to middle managers; and Parts III and IV to those involved in operational experience feedback. Because of widely different plant designs, operating and management styles, cultural practices, and other factors affecting plant operations, no OSART findings were applicable to all of the plants visited in 1993 and 1994. Individual findings varied considerably in scope and significance. However, the findings do reflect some common strengths and opportunities for improvement. 4 tabs

  8. Highlights of the UKAEA Underlying Research Programme: April 1988-March 1989

    International Nuclear Information System (INIS)

    1990-01-01

    Investment in fundamental research is essential to the success of any organisation whose business is the selling of research and development and the services relating to it. The resulting scientific and technical excellence is the hall-mark of a major contract research and development organisation and its main product. Fundamental research in the AEA is co-ordinated through the Underlying Research Programme. The Programme has to keep closely in touch with all the applied projects, in order to identify within these the problems that are hindering progress and might therefore benefit from further investigation. It also has the responsibility for developing new skills and techniques across the AEA. This brochure highlights some of the projects undertaken as part of the Underlying Research Programme. The Programme is organised into fifteen different areas of research, with the research projects not obviously fitting into any of these areas having a separate section to themselves. The text introduces each of these areas in turn, and then describes two or three examples of the sort of work undertaken within it. The areas are radiation effects, fracture studies, chemical effects at surfaces, surface physics and corrosion, fluid mechanics and heat transfer, nuclear studies, neutron beam studies, theoretical sciences, instrumentation, reactor physics and control, fabrication processes, laser isotope separation, nuclear fuel cycle studies, quantum electronics and radiological protection. (author)

  9. Highlighting the Structure-Function Relationship of the Brain with the Ising Model and Graph Theory

    Directory of Open Access Journals (Sweden)

    T. K. Das

    2014-01-01

    Full Text Available With the advent of neuroimaging techniques, it becomes feasible to explore the structure-function relationships in the brain. When the brain is not involved in any cognitive task or stimulated by any external output, it preserves important activities which follow well-defined spatial distribution patterns. Understanding the self-organization of the brain from its anatomical structure, it has been recently suggested to model the observed functional pattern from the structure of white matter fiber bundles. Different models which study synchronization (e.g., the Kuramoto model or global dynamics (e.g., the Ising model have shown success in capturing fundamental properties of the brain. In particular, these models can explain the competition between modularity and specialization and the need for integration in the brain. Graphing the functional and structural brain organization supports the model and can also highlight the strategy used to process and organize large amount of information traveling between the different modules. How the flow of information can be prevented or partially destroyed in pathological states, like in severe brain injured patients with disorders of consciousness or by pharmacological induction like in anaesthesia, will also help us to better understand how global or integrated behavior can emerge from local and modular interactions.

  10. Prophylactic platelets in dengue: survey responses highlight lack of an evidence base.

    Directory of Open Access Journals (Sweden)

    James Whitehorn

    Full Text Available Dengue is the most important arboviral infection of humans. Thrombocytopenia is frequently observed in the course of infection and haemorrhage may occur in severe disease. The degree of thrombocytopenia correlates with the severity of infection, and may contribute to the risk of haemorrhage. As a result of this prophylactic platelet transfusions are sometimes advocated for the prevention of haemorrhage. There is currently no evidence to support this practice, and platelet transfusions are costly and sometimes harmful. We conducted a global survey to assess the different approaches to the use of platelets in dengue. Respondents were all physicians involved with the treatment of patients with dengue. Respondents were asked that their answers reflected what they would do if they were the treating physician. We received responses from 306 physicians from 20 different countries. The heterogeneity of the responses highlights the variation in clinical practice and lack of an evidence base in this area and underscores the importance of prospective clinical trials to address this key question in the clinical management of patients with dengue.

  11. Patient engagement: four case studies that highlight the potential for improved health outcomes and reduced costs.

    Science.gov (United States)

    Laurance, Jeremy; Henderson, Sarah; Howitt, Peter J; Matar, Mariam; Al Kuwari, Hanan; Edgman-Levitan, Susan; Darzi, Ara

    2014-09-01

    The energy of patients and members of the public worldwide who care about improving health is a huge, but still largely unrecognized and untapped, resource. The aim of patient engagement is to shift the clinical paradigm from determining "what is the matter?" to discovering "what matters to you?" This article presents four case studies from around the world that highlight the proven and potential abilities of increased patient engagement to improve health outcomes and reduce costs, while extending the reach of treatment and diagnostic programs into the community. The cases are an online mental health community in the United Kingdom, a genetic screening program in the United Arab Emirates, a World Health Organization checklist for new mothers, and a hospital-based patient engagement initiative in the United States. Evidence from these and similar endeavors suggests that closer collaboration on the part of patients, families, health care providers, health care systems, and policy makers at multiple levels could help diverse nations provide more effective and population-appropriate health care with fewer resources. Project HOPE—The People-to-People Health Foundation, Inc.

  12. Simple method for highlighting the temperature distribution into a liquid sample heated by microwave power field

    International Nuclear Information System (INIS)

    Surducan, V.; Surducan, E.; Dadarlat, D.

    2013-01-01

    Microwave induced heating is widely used in medical treatments, scientific and industrial applications. The temperature field inside a microwave heated sample is often inhomogenous, therefore multiple temperature sensors are required for an accurate result. Nowadays, non-contact (Infra Red thermography or microwave radiometry) or direct contact temperature measurement methods (expensive and sophisticated fiber optic temperature sensors transparent to microwave radiation) are mainly used. IR thermography gives only the surface temperature and can not be used for measuring temperature distributions in cross sections of a sample. In this paper we present a very simple experimental method for temperature distribution highlighting inside a cross section of a liquid sample, heated by a microwave radiation through a coaxial applicator. The method proposed is able to offer qualitative information about the heating distribution, using a temperature sensitive liquid crystal sheet. Inhomogeneities as smaller as 1°-2°C produced by the symmetry irregularities of the microwave applicator can be easily detected by visual inspection or by computer assisted color to temperature conversion. Therefore, the microwave applicator is tuned and verified with described method until the temperature inhomogeneities are solved

  13. Comparative Analysis Highlights Variable Genome Content of Wheat Rusts and Divergence of the Mating Loci

    Directory of Open Access Journals (Sweden)

    Christina A. Cuomo

    2017-02-01

    Full Text Available Three members of the Puccinia genus, Puccinia triticina (Pt, P. striiformis f.sp. tritici (Pst, and P. graminis f.sp. tritici (Pgt, cause the most common and often most significant foliar diseases of wheat. While similar in biology and life cycle, each species is uniquely adapted and specialized. The genomes of Pt and Pst were sequenced and compared to that of Pgt to identify common and distinguishing gene content, to determine gene variation among wheat rust pathogens, other rust fungi, and basidiomycetes, and to identify genes of significance for infection. Pt had the largest genome of the three, estimated at 135 Mb with expansion due to mobile elements and repeats encompassing 50.9% of contig bases; in comparison, repeats occupy 31.5% for Pst and 36.5% for Pgt. We find all three genomes are highly heterozygous, with Pst [5.97 single nucleotide polymorphisms (SNPs/kb] nearly twice the level detected in Pt (2.57 SNPs/kb and that previously reported for Pgt. Of 1358 predicted effectors in Pt, 784 were found expressed across diverse life cycle stages including the sexual stage. Comparison to related fungi highlighted the expansion of gene families involved in transcriptional regulation and nucleotide binding, protein modification, and carbohydrate degradation enzymes. Two allelic homeodomain pairs, HD1 and HD2, were identified in each dikaryotic Puccinia species along with three pheromone receptor (STE3 mating-type genes, two of which are likely representing allelic specificities. The HD proteins were active in a heterologous Ustilago maydis mating assay and host-induced gene silencing (HIGS of the HD and STE3 alleles reduced wheat host infection.

  14. Genes of the major histocompatibility complex highlight interactions of the innate and adaptive immune system

    Directory of Open Access Journals (Sweden)

    Barbara Lukasch

    2017-08-01

    Full Text Available Background A well-functioning immune defence is crucial for fitness, but our knowledge about the immune system and its complex interactions is still limited. Major histocompatibility complex (MHC molecules are involved in T-cell mediated adaptive immune responses, but MHC is also highly upregulated during the initial innate immune response. The aim of our study was therefore to determine to what extent the highly polymorphic MHC is involved in interactions of the innate and adaptive immune defence and if specific functional MHC alleles (FA or heterozygosity at the MHC are more important. Methods To do this we used captive house sparrows (Passer domesticus to survey MHC diversity and immune function controlling for several environmental factors. MHC class I alleles were identified using parallel amplicon sequencing and to mirror immune function, several immunological tests that correspond to the innate and adaptive immunity were conducted. Results Our results reveal that MHC was linked to all immune tests, highlighting its importance for the immune defence. While all innate responses were associated with one single FA, adaptive responses (cell-mediated and humoral were associated with several different alleles. Discussion We found that repeated injections of an antibody in nestlings and adults were linked to different FA and hence might affect different areas of the immune system. Also, individuals with a higher number of different FA produced a smaller secondary response, indicating a disadvantage of having numerous MHC alleles. These results demonstrate the complexity of the immune system in relation to the MHC and lay the foundation for other studies to further investigate this topic.

  15. Genes of the major histocompatibility complex highlight interactions of the innate and adaptive immune system.

    Science.gov (United States)

    Lukasch, Barbara; Westerdahl, Helena; Strandh, Maria; Winkler, Hans; Moodley, Yoshan; Knauer, Felix; Hoi, Herbert

    2017-01-01

    A well-functioning immune defence is crucial for fitness, but our knowledge about the immune system and its complex interactions is still limited. Major histocompatibility complex (MHC) molecules are involved in T-cell mediated adaptive immune responses, but MHC is also highly upregulated during the initial innate immune response. The aim of our study was therefore to determine to what extent the highly polymorphic MHC is involved in interactions of the innate and adaptive immune defence and if specific functional MHC alleles (FA) or heterozygosity at the MHC are more important. To do this we used captive house sparrows ( Passer domesticus ) to survey MHC diversity and immune function controlling for several environmental factors. MHC class I alleles were identified using parallel amplicon sequencing and to mirror immune function, several immunological tests that correspond to the innate and adaptive immunity were conducted. Our results reveal that MHC was linked to all immune tests, highlighting its importance for the immune defence. While all innate responses were associated with one single FA, adaptive responses (cell-mediated and humoral) were associated with several different alleles. We found that repeated injections of an antibody in nestlings and adults were linked to different FA and hence might affect different areas of the immune system. Also, individuals with a higher number of different FA produced a smaller secondary response, indicating a disadvantage of having numerous MHC alleles. These results demonstrate the complexity of the immune system in relation to the MHC and lay the foundation for other studies to further investigate this topic.

  16. Advances and highlights in allergen immunotherapy: On the way to sustained clinical and immunologic tolerance.

    Science.gov (United States)

    Berings, Margot; Karaaslan, Cagatay; Altunbulakli, Can; Gevaert, Philippe; Akdis, Mübeccel; Bachert, Claus; Akdis, Cezmi A

    2017-11-01

    Allergen immunotherapy (AIT) is an effective treatment strategy for allergic diseases and has been used for more than 100 years. In recent years, however, the expectations on concepts, conduct, statistical evaluation, and reporting have developed significantly. Products have undergone dose-response and confirmative studies in adults and children to provide evidence for the optimal dosage, safety, and efficacy of AIT vaccines using subcutaneous and sublingual delivery pathways in large patient cohorts, ensuring solid conclusions to be drawn from them for the advantage of patients and societies alike. Those standards should be followed today, and products answering to them should be preferred over others lacking optimization and proof of efficacy and safety. Molecular and cellular mechanisms of AIT include early mast cell and basophil desensitization effects, regulation of T- and B-cell responses, regulation of IgE and IgG 4 production, and inhibition of responses from eosinophils, mast cells, and basophils in the affected tissues. There were many developments to improve vaccination strategies, demonstration of new molecules involved in molecular mechanisms, and demonstration of new biomarkers for AIT during the last few years. The combination of probiotics, vitamins, and biological agents with AIT is highlighting current advances. Development of allergoids and recombinant and hypoallergenic vaccines to skew the immune response from IgE to IgG 4 and regulation of dendritic cell, mast cell, basophil, innate lymphoid cell, T-cell, and B-cell responses to allergens are also discussed in detail. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  17. Oxidation of metabolites highlights the microbial interactions and role of Acetobacter pasteurianus during cocoa bean fermentation.

    Science.gov (United States)

    Moens, Frédéric; Lefeber, Timothy; De Vuyst, Luc

    2014-03-01

    Four cocoa-specific acetic acid bacterium (AAB) strains, namely, Acetobacter pasteurianus 386B, Acetobacter ghanensis LMG 23848(T), Acetobacter fabarum LMG 24244(T), and Acetobacter senegalensis 108B, were analyzed kinetically and metabolically during monoculture laboratory fermentations. A cocoa pulp simulation medium (CPSM) for AAB, containing ethanol, lactic acid, and mannitol, was used. All AAB strains differed in their ethanol and lactic acid oxidation kinetics, whereby only A. pasteurianus 386B performed a fast oxidation of ethanol and lactic acid into acetic acid and acetoin, respectively. Only A. pasteurianus 386B and A. ghanensis LMG 23848(T) oxidized mannitol into fructose. Coculture fermentations with A. pasteurianus 386B or A. ghanensis LMG 23848(T) and Lactobacillus fermentum 222 in CPSM for lactic acid bacteria (LAB) containing glucose, fructose, and citric acid revealed oxidation of lactic acid produced by the LAB strain into acetic acid and acetoin that was faster in the case of A. pasteurianus 386B. A triculture fermentation with Saccharomyces cerevisiae H5S5K23, L. fermentum 222, and A. pasteurianus 386B, using CPSM for LAB, showed oxidation of ethanol and lactic acid produced by the yeast and LAB strain, respectively, into acetic acid and acetoin. Hence, acetic acid and acetoin are the major end metabolites of cocoa bean fermentation. All data highlight that A. pasteurianus 386B displayed beneficial functional roles to be used as a starter culture, namely, a fast oxidation of ethanol and lactic acid, and that these metabolites play a key role as substrates for A. pasteurianus in its indispensable cross-feeding interactions with yeast and LAB during cocoa bean fermentation.

  18. Self-assessment of safety culture in nuclear installations. Highlights and good practices

    International Nuclear Information System (INIS)

    2002-11-01

    This report summarizes the findings of two IAEA Technical Committee Meetings on Safety Culture Self-Assessment Highlights and Good Practices. The meetings took place on 3-5 June 1998 and 23-25 October 2000 in Vienna, and involved an international cross-section of representatives who participated both in plenary discussions and working groups. The purpose of the meetings was to discuss the practical implications of evolutionary changes in the development of safety culture, and to share international experience, particularly on the methods used for the assessment of safety culture and good practices for its enhancement in an organization. The working groups were allocated specific topics for discussion, which included the following: organizational factors influencing the implementation of actions to improve safety culture; how to measure, effectively, progress in implementing solutions to safety culture problems; the symptoms of a weakening safety culture; the suitability of different methods for assessing safety culture; the achievement of sustainable improvements in safety culture using the results of assessment; the potential threats to the continuation of a strong safety culture in an organization from the many challenges facing the nuclear industry. The working groups, when appropriate, considered issues from both the utility's and the regulator's perspectives. This report will be of interest to all organizations who wish to assess and achieve a strong and sustainable safety culture. This includes not only nuclear power plants, but also other sectors of the nuclear industry such as uranium mines and mills, nuclear fuel fabrication facilities, nuclear waste repositories, research reactors, accelerators, radiography facilities, etc. The report specifically supplements other IAEA publications on this subject

  19. Radiotelemetry and wildlife: Highlighting a gap in the knowledge on radiofrequency radiation effects

    International Nuclear Information System (INIS)

    Balmori, Alfonso

    2016-01-01

    Radio transmitters and associated devices may induce negative effects that can bias the results of ongoing research. The main documented effects of radio transmitters on animals include reduced survival, decreased productivity, changes in behaviour and movement patterns and a biased sex ratio. The only factors that have claimed responsibility for these possible damages are the weight of the radio transmitter and associated devices, and the attachment type. The electromagnetic radiation produced by radio transmitters has not been considered so far in research. There have been no studies evaluating the effects of non-ionising electromagnetic radiation (radiofrequency signals) necessary for tracking, although the problems found were significantly associated with the length of time that animals had been carrying their radio transmitters. Similar problems as those in radiotracked animals have been found in numerous studies with animals exposed to radiofrequency radiation for a sufficient amount of time. Laboratory scientists investigating the orientation of animals know they have to shield the place where experiments are performed to prevent interference from man-made radiation, as anthropogenic signals may distort the results. It is paradoxical that, at the same time, field scientists investigating the movements and other aspects of animal biology are providing animals with radio transmitters that emit the same type of radiation, since this may affect the results concerning their orientation and movement. This paper identifies gaps in the knowledge that should be investigated in-depth. The possibility that the radiofrequency radiation from radiotracking devices is responsible for the findings should be considered. Considering this factor may allow researchers to best understand the long-term effects found. - Highlights: • Radiotracking may induce negative effects that can bias the results. • Effects have been documented on survival, reproduction and behaviour.

  20. Comparative analysis of transposable elements highlights mobilome diversity and evolution in vertebrates.

    Science.gov (United States)

    Chalopin, Domitille; Naville, Magali; Plard, Floriane; Galiana, Delphine; Volff, Jean-Nicolas

    2015-01-09

    Transposable elements (TEs) are major components of vertebrate genomes, with major roles in genome architecture and evolution. In order to characterize both common patterns and lineage-specific differences in TE content and TE evolution, we have compared the mobilomes of 23 vertebrate genomes, including 10 actinopterygian fish, 11 sarcopterygians, and 2 nonbony vertebrates. We found important variations in TE content (from 6% in the pufferfish tetraodon to 55% in zebrafish), with a more important relative contribution of TEs to genome size in fish than in mammals. Some TE superfamilies were found to be widespread in vertebrates, but most elements showed a more patchy distribution, indicative of multiple events of loss or gain. Interestingly, loss of major TE families was observed during the evolution of the sarcopterygian lineage, with a particularly strong reduction in TE diversity in birds and mammals. Phylogenetic trends in TE composition and activity were detected: Teleost fish genomes are dominated by DNA transposons and contain few ancient TE copies, while mammalian genomes have been predominantly shaped by nonlong terminal repeat retrotransposons, along with the persistence of older sequences. Differences were also found within lineages: The medaka fish genome underwent more recent TE amplification than the related platyfish, as observed for LINE retrotransposons in the mouse compared with the human genome. This study allows the identification of putative cases of horizontal transfer of TEs, and to tentatively infer the composition of the ancestral vertebrate mobilome. Taken together, the results obtained highlight the importance of TEs in the structure and evolution of vertebrate genomes, and demonstrate their major impact on genome diversity both between and within lineages. © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  1. OSART programme highlights 1995-1996. Operational safety practices in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-05-01

    The IAEA Operational Safety Review Team (OSART) programme provides advice and assistance to Member States in enhancing the operational safety of nuclear power plants. This report continues the practice of summarizing mission results so that all the aspects of OSART missions, Pre-OSART missions and good practices are to be found in one volume. It also includes results of follow-up visits. Attempts have been made in this report to highlight the most significant findings whilst retaining as much of the vital background information as possible. This report is in four parts: Part I summarizes the most significant observations made during the missions and follow-up visits during 1995-1996; Part II, in chronological order, is an overview of the major strengths and opportunities for improvement identified during each OSART mission and summaries of follow-up visits performed during the period; Part III lists good practices that were identified during 1995 and 1996; and Part IV presents the OSART mission results (OSMIR) database. Each part of the report is intended for different levels in operating and regulatory organizations but not exclusively so. Part I is primarily to the executive management level; Part II to middle managers; and Parts III and IV to those involved in operational experience feedback. Because of widely different plant designs, operating and management styles, cultural practices, and other factors affecting plant operations, no OSART findings were applicable to all of the plants visited in 1995 and 1996. Individual findings varied considerably in scope and significance. However, the findings do reflect some common strengths and opportunities for improvement

  2. Radiotelemetry and wildlife: Highlighting a gap in the knowledge on radiofrequency radiation effects

    Energy Technology Data Exchange (ETDEWEB)

    Balmori, Alfonso, E-mail: balmaral@jcyl.es

    2016-02-01

    Radio transmitters and associated devices may induce negative effects that can bias the results of ongoing research. The main documented effects of radio transmitters on animals include reduced survival, decreased productivity, changes in behaviour and movement patterns and a biased sex ratio. The only factors that have claimed responsibility for these possible damages are the weight of the radio transmitter and associated devices, and the attachment type. The electromagnetic radiation produced by radio transmitters has not been considered so far in research. There have been no studies evaluating the effects of non-ionising electromagnetic radiation (radiofrequency signals) necessary for tracking, although the problems found were significantly associated with the length of time that animals had been carrying their radio transmitters. Similar problems as those in radiotracked animals have been found in numerous studies with animals exposed to radiofrequency radiation for a sufficient amount of time. Laboratory scientists investigating the orientation of animals know they have to shield the place where experiments are performed to prevent interference from man-made radiation, as anthropogenic signals may distort the results. It is paradoxical that, at the same time, field scientists investigating the movements and other aspects of animal biology are providing animals with radio transmitters that emit the same type of radiation, since this may affect the results concerning their orientation and movement. This paper identifies gaps in the knowledge that should be investigated in-depth. The possibility that the radiofrequency radiation from radiotracking devices is responsible for the findings should be considered. Considering this factor may allow researchers to best understand the long-term effects found. - Highlights: • Radiotracking may induce negative effects that can bias the results. • Effects have been documented on survival, reproduction and behaviour.

  3. Karst system vadose zone hydrodynamics highlighted by an integrative geophysical and hydrogeological monitoring

    Science.gov (United States)

    Watlet, A.; Van Camp, M. J.; Francis, O.; Poulain, A.; Hallet, V.; Rochez, G.; Kaufmann, O.

    2015-12-01

    The vadose zone of karst systems plays an important role on the water dynamics. In particular, temporary perched aquifers can appear in the subsurface due to changes of climate conditions, diminished evapotranspiration and differences of porosity relative to deeper layers. It is therefore crucial, but challenging, to separate the hydrological signature of the vadose zone from the one of the saturated zone for understanding hydrological processes that occur in the vadose zone. Although many difficulties are usually encountered when studying karst environments due to their heterogeneities, cave systems offer an outstanding opportunity to investigate vadose zone from the inside with various techniques. We present results covering two years of hydrogeological and geophysical monitoring at the Rochefort Cave Laboratory (RCL), located in the Variscan fold-and-thrust belt (Belgium), a region that shows many karstic networks within Devonian limestone units. Hydrogeological data such as flows and levels monitoring or tracer tests performed in both vadose and saturated zones bring valuable information on the hydrological context of the studied area. Combining those results with geophysical measurements allows validating and imaging them with more integrative techniques. A microgravimetric monitoring involves a superconducting gravimeter continuously measuring at the surface of the RCL. Early in 2015, a second relative gravimeter was installed in the underlying cave system located 35 meters below the surface. This set up allows highlighting vadose gravity changes. These relative measurements are calibrated using an absolute gravimeter. 12 additional stations (7 at the surface, 5 in the cave) are monitored on a monthly basis by a spring gravimeter. To complete these gravimetric measurements, the site has been equipped with a permanent Electrical Resistivity Tomography (ERT) monitoring system comprising an uncommon array of surface, borehole and cave electrodes. Although such

  4. Systematic reviews in context: highlighting systematic reviews relevant to Africa in the Pan African Medical Journal.

    Science.gov (United States)

    Wiysonge, Charles Shey; Kamadjeu, Raoul; Tsague, Landry

    2016-01-01

    contribute in enhancing the value of research in Africa, the Pan African Medical Journal will start a new regular column that will highlight priority systematic reviews relevant to the continent.

  5. South African Climates: Highlights From International Ocean Discovery Program Expedition 361

    Science.gov (United States)

    Hemming, S. R.; Hall, I. R.; LeVay, L.

    2016-12-01

    International Ocean Discovery Program Expedition 361 drilled six sites on the southeast African margin and in the Indian-Atlantic ocean gateway, southwest Indian Ocean, from 30 January to 31 March 2016. In total, 5175 m of core was recovered, with an average recovery of 102%, during 29.7 days of on-site operations. The sites, situated in the Mozambique Channel, at locations directly influenced by discharge from the Zambezi and Limpopo River catchments, the Natal Valley, the Agulhas Plateau, and the Cape Basin were targeted to reconstruct the history of the Greater Agulhas Current System over the past 5 Ma. The Agulhas Current transports 70 Sv of warm and saline surface waters from the tropical Indian Ocean along the East African margin to the tip of Africa. Exchanges of heat and moisture with the atmosphere influence southern African rainfall patterns. Recent ocean model and paleoceanographic data further point at a potential role of the Agulhas Current in controlling the strength and mode of the Atlantic Meridional Overturning Circulation (AMOC) during the Late Pleistocene. The main objectives of the expedition were to document the oceanographic properties of the Agulhas Current through tectonic and climatic changes during the Plio-Pleistocene, to determine the dynamics of the Indian-Atlantic gateway circulation during this time, to examine the connection of the Agulhas leakage and AMOC, to address the influence of the Agulhas Current on African terrestrial climates and potential links to Human evolution. Additionally, the Expedition set out to fulfill the needs of the Ancillary Project Letter, consisting of high-resolution interstitial water samples that will, and to constrain the temperature and salinity profiles of the ocean during the Last Glacial Maximum. Here we highlight some of the expedition successes and show how it has made major strides toward fulfilling each of these objectives. The recovered sequences allowed complete spliced stratigraphic sections

  6. Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study.

    Directory of Open Access Journals (Sweden)

    Valborg Gudmundsdottir

    Full Text Available Glucagon-like peptide 1 (GLP-1 stimulated insulin secretion has a considerable heritable component as estimated from twin studies, yet few genetic variants influencing this phenotype have been identified. We performed the first genome-wide association study (GWAS of GLP-1 stimulated insulin secretion in non-diabetic individuals from the Netherlands Twin register (n = 126. This GWAS was enhanced using a tissue-specific protein-protein interaction network approach. We identified a beta-cell protein-protein interaction module that was significantly enriched for low gene scores based on the GWAS P-values and found support at the network level in an independent cohort from Tübingen, Germany (n = 100. Additionally, a polygenic risk score based on SNPs prioritized from the network was associated (P < 0.05 with glucose-stimulated insulin secretion phenotypes in up to 5,318 individuals in MAGIC cohorts. The network contains both known and novel genes in the context of insulin secretion and is enriched for members of the focal adhesion, extracellular-matrix receptor interaction, actin cytoskeleton regulation, Rap1 and PI3K-Akt signaling pathways. Adipose tissue is, like the beta-cell, one of the target tissues of GLP-1 and we thus hypothesized that similar networks might be functional in both tissues. In order to verify peripheral effects of GLP-1 stimulation, we compared the transcriptome profiling of ob/ob mice treated with liraglutide, a clinically used GLP-1 receptor agonist, versus baseline controls. Some of the upstream regulators of differentially expressed genes in the white adipose tissue of ob/ob mice were also detected in the human beta-cell network of genes associated with GLP-1 stimulated insulin secretion. The findings provide biological insight into the mechanisms through which the effects of GLP-1 may be modulated and highlight a potential role of the beta-cell expressed genes RYR2, GDI2, KIAA0232, COL4A1 and COL4A2 in GLP-1 stimulated

  7. Research highlights on: the use of induced mutations for plant improvement in Malaysia

    International Nuclear Information System (INIS)

    1998-01-01

    radiosensitivity tests, plant improvement progranunes and other work were described for many crops including rice, banana, soybean, groundnut, mungbean, rubber, pepper and others. This section also highlights and describes the major achievements of mutation breeding in the country. Section IV provides the concluding remarks which stress the importance of continuing the research work on induced mutations to augment breeding programmes and to enhance the agricultural development in Malaysia. Finally, Sections V and VI list the abstracts and references of research work that had been carried out in the past

  8. Addressing Issues of Broadening Participation Highlighted in the Report on the Future of Undergraduate Geoscience Education

    Science.gov (United States)

    McDaris, J. R.; Manduca, C. A.; Macdonald, H.; Iverson, E. A. R.

    2015-12-01

    The final report for the Summit on the Future of Geoscience Education lays out a consensus on issues that must be tackled by the geoscience community collectively if there are to be enough qualified people to fill the large number of expected geoscience job vacancies over the coming decade. Focus areas cited in the report include: Strengthening the connections between two-year colleges and four-year institutions Sharing and making use of successful recruitment and retention practices for students from underrepresented groups Making students aware of high-quality job prospects in the geosciences as well as its societal relevance The InTeGrate STEP Center for the Geosciences, the Supporting and Advancing Geoscience Education at Two-Year Colleges (SAGE 2YC) program, and the Building Strong Geoscience Departments (BSGD) project together have developed a suite of web resources to help faculty and program leaders begin to address these and other issues. These resources address practices that support the whole student, both in the classroom and as a part of the co-curriculum as well as information on geoscience careers, guidance for developing coherent degree programs, practical advice for mentoring and advising, and many others. In addition to developing web resources, InTeGrate has also undertaken an effort to profile successful program practices at a variety of institutions. An analysis of these data shows several common themes (e.g. proactive marketing, community building, research experiences) that align well with the existing literature on what works to support student success. But there are also indications of different approaches and emphases between Minority Serving Institutions (MSIs) and Primarily White Institutions (PWIs) as well as between different kinds of MSIs. Highlighting the different strategies in use can point both MSIs and PWIs to possible alternate solutions to the challenges their students face. InTeGrate - http

  9. [Key vessels assessment and operation highlights in laparoscopic extended right hemicolectomy].

    Science.gov (United States)

    Wang, Hao; Zhao, Quanquan

    2018-03-25

    Laparoscopic radical colectomies have been more widely used gradually, among which laparoscopic extended right hemicolectomy is considered as the most difficult procedure. The difficulty of extended right hemicolectomy lies in the need to dissect lymph nodes along the superior mesenteric vein (SMV) and disconnect numerous and possible aberrant vessels. To address this problem, we emphasize two points in key vessel assessment: getting familiar with the anatomy along the medial-to-lateral approach and having a good understanding about the preoperative imaging presentations. An accurately preoperative imaging assessment by abdominal enhanced CT can help the surgeon understand the relative position of the key vessels to be dealt with during operation and the situation of the possible aberrant vessels so as to guide the procedure more effectively and facilitate the prevention and management of the intraoperative complications. During operation, the operator should pay special attention to the management of the vessels in the ileocolic vessel region, Henle's trunk and middle colon vessels. The operation highlights of the key vessels are as follows: (1) The ileocolic vessels: identifying the Toldt's gap correctly and opening the vascular sheath of the SMV securely; making sure that the duodenum is well protected. (2) Henle's trunk: dissecting along the surface of the Henle's trunk; preserving the anterior superior pancreaticoduodenal vein (ASPDV) and main trunk of the Henle's trunk; disconnecting the roots of the right colic vein (RCV) and right gastroepiploic vein (RGEV), and then dissecting lymph nodes along the surface of the pancreas. (3) The middle colon vessels: identifying the root of the middle colon vessel along the lower edge of the pancreas; avoiding entering behind the pancreas; mobilizing the transverse mesocolon sufficiently along the surface of the pancreas. Finally, we discuss and analyze the disputes currently existing in laparoscopic extended right

  10. First highlights of the Dynamics-Aerosol-Chemistry-Cloud Interactions in West Africa (DACCIWA) field campaigns

    Science.gov (United States)

    Liousse, C.; Knippertz, P.; Flamant, C.; Adon, J.; Akpo, A.; Annesi-Maesano, I.; Assamoi, E.; Baeza, A.; Julien, B.; Bedou, M.; Brooks, B. J.; Chiu, J. Y. C.; Chiron, C.; Coe, H.; Danuor, S.; Djossou, J.; Evans, M. J.; Fayomi, B.; Fink, A. H.; Galy-Lacaux, C.; Gardrat, E.; Jegede, O.; Kalthoff, N.; Kedote, M.; Keita, S.; Kouame, K.; Konare, A.; Leon, J. F.; Mari, C. H.; Lohou, F.; Roblou, L.; Schlager, H.; Schwarzenboeck, A.; Toure, E. N.; Veronique, Y.

    2016-12-01

    order to characterize toxicological effects of size-speciated aerosol chemical composition. First highlights on the flight sampling strategy, the acquired datasets, and accompanying modelling work will be presented.

  11. The Mission Accessible Near-Earth Object Survey (MANOS) -- Science Highlights

    Science.gov (United States)

    Moskovitz, Nicholas; Thirouin, Audrey; Binzel, Richard; Burt, Brian; Christensen, Eric; DeMeo, Francesca; Endicott, Thomas; Hinkle, Mary; Mommert, Michael; Person, Michael; Polishook, David; Siu, Hosea; Thomas, Cristina; Trilling, David; Willman, Mark

    2015-08-01

    providing a portal to facilitate observation planning and coordination within the small body observer community. We will present highlights of these early MANOS science results.

  12. Variability in Antibiotic Regimens for Surgical Necrotizing Enterocolitis Highlights the Need for New Guidelines.

    Science.gov (United States)

    Blackwood, Brian P; Hunter, Catherine J; Grabowski, Julia

    antibiotic overuse, our findings highlight the need for guidelines in the antibiotic treatment of NEC and suggest that an abbreviated course of post-operative antibiotics may be safe.

  13. OSART mission highlights 2001-2003. Operational safety practices in nuclear power plants

    International Nuclear Information System (INIS)

    2005-05-01

    The IAEA Operational Safety Review Team (OSART) programme provides advice and assistance to Member States in enhancing the operational safety of nuclear power plants (NPPs). Careful design and high quality of construction are prerequisites for a safe nuclear power plant. However, a plant's safety depends ultimately on the ability and conscientiousness of the operating personnel and on the plant programmes, processes and working methods. An OSART mission compares a facility's operational performance with IAEA Safety Standards and proven good international practices. The OSART reviews are available to all countries with nuclear power plants in operation, but also approaching operation, commissioning or in earlier stages of construction (Pre-OSART). Most countries have participated in the programme by hosting one or more OSART missions or by making experts available to participate in missions. Operational safety missions can also be part of the design review missions of nuclear power plants and are known as Safety Review Missions (SRMs). Teams that review only a few specific areas or a specific issue are called Expert missions. Follow-up visits are a standard part of the OSART programme and are conducted between 12 to 18 months following the OSART mission. This report continues the practice of summarizing mission results so that all the aspects of OSART missions, Pre-OSART missions and OSART good practices are to be found in one document. It also includes the results of follow-up visits. Attempts have been made in this report to highlight the most significant findings while retaining as much of the vital background information as possible. This report is in three parts: Part I summarizes the most significant observations made during the missions and follow-up visits between 2001 and 2003; Part II, in chronological order, reviews the major strengths and opportunities for improvement identified during each OSART mission and summarizes the follow-up visits performed

  14. Highlight of Grid-connected PV systems in administrative buildings in Egypt

    Directory of Open Access Journals (Sweden)

    Dina Said

    2017-03-01

    buildings. Cost- effective EE measures should be implemented prior to or at the same time as implemented PV program. The amount of electricity that a PV system produces depends on the system type, orientation and the available solar resource. In 2014, the GOE issued the Feed-in Tariff program to further promote RE technologies in general and PV in particular. Egyptian Electric Utility and Consumer Protection Regulatory Authority (Egypt ERA has set the regulations, promotion and awareness for PVs. This approach has been applied for administrative buildings as well.The paper highlights the impact of the previously mentioned mechanisms in deploying PV technologies through small scale projects. It also represents a cost- benefit analysis for the installed systems taking into account the measured value for PV parameters (kWh/kWp, PSH and daily load profiles of the selected administrative buildings.

  15. Sexual Assault and Sexual Harassment in the U.S. Military: Highlights from the 2014 RAND Military Workplace Study

    Science.gov (United States)

    2015-01-01

    assault, sexual harassment , and gender discrimination in the military. The resulting study, the RAND Military Workplace Study (RMWS), invited close to...members are highlighted in this brief. Sexual Assault and Sexual Harassment in the U.S. Military HigHligHts from tHe 2014 rAND militAry WorkplAce stuDy...significantly higher rates than men : 22 percent of women and 7 percent of men experienced sexual harassment in the past year. In addition, we estimate

  16. Research highlights under Contract DE-AC02-76ER03072, February 1, 1981-July 31, 1981

    International Nuclear Information System (INIS)

    Shoemaker, F.C.

    1981-01-01

    Research projects are highlighted including: a study of rare muon induced reactions; a search for eta/sub c/ mesons; hadronic production of charmed particles; production of high-mass dimuons by pions; forward production of massive particles; the crystal ball project at SPEAR; parallel plate avalanche chamber development; and tests of quantum mechanics

  17. Looking Forward: Texas and Its Elderly. Highlights of the Robert Lee Sutherland Seminar (4th, Austin, Texas, May 12, 1984).

    Science.gov (United States)

    Coleman, Marion Tolbert, Ed.; And Others

    This document presents the program agenda and highlights from the one-day Robert Lee Sutherland Seminar held to examine the current status and the future of the elderly population of Texas. Included is the speech, "The Longevity Revolution" by Robert N. Butler, in which is discussed the gain in life expectancy, the feminization of aging,…

  18. Highlights of LHCb Measurement in Rare Decays and Discovery of First Pentaquark States with Run 1 Data

    CERN Document Server

    Ukleja, Artur

    2016-01-01

    In pp collisions at the LHC, the LHCb experiment has collected the world’s largest sample of beauty and charmed hadrons. Very precise mea- surements obtained from these data provide tests of the Standard Model, which are indirect searches for new physics. The highlights obtained using data of an integrated luminosity of 3.0 fb

  19. Development highlights of micro-nano technologies in the MENA region and pathways for initiatives to support and network

    NARCIS (Netherlands)

    Al-Rawashdeh, M.I.M.; Alfeeli, B.; Rawashdeh, A.M.; Hessel, V.

    2013-01-01

    Current developments in the field of micro-nano technologies in the Middle East and North Africa (MENA) region are highlighted. Firstly, the scientific outcome of micro-nano technologies from the MENA region is analyzed. Egypt and Saudi Arabia are the leading countries, with >50% of the total MENA

  20. Summary and highlights

    Directory of Open Access Journals (Sweden)

    Alimonti G.

    2013-06-01

    Full Text Available Energy means development, and access to energy and electricity should be possible for everyone. The energy challenge for the years to come is to have a sustainable energy supply and after the week spent in Varenna it is clear that “sustainable” cannot be identified with green gas emission reduction only: it has to be an energy supply system respectful of the environment and the humankind, able to provide reliable and affordable energy to the whole world population. This is definitely not an easy challenge: no single energy technology will suffice to safeguard our future and any possible solution has to be exploited at its best, from renewable to nuclear energy, from clean fossil fuels to biofuels. Last but not least, it is the energy efficiency that, given the actual technology, may give the most important and immediate contribution to this challenge. Meanwhile researchers must examine a broad range of options and develop different kinds of technologies: only new investments on R&D can allow to meet the growing demand for energy in a responsible, equitable, and sustainable way.

  1. Highlights on SUSY phenomenology

    International Nuclear Information System (INIS)

    Masiero, Antonio

    2004-01-01

    In spite of the extraordinary success of the Standard Model (SM) supplemented with massive neutrinos in accounting for the whole huge bulk of phenomenology which has been accumulating in the last three decades, there exist strong theoretical reasons in particle physics and significant 'observational' hints in astroparticle physics for new physics beyond it. My lecture is devoted to a critical assessment of our belief in such new physics at the electroweak scale, in particular identifying it with low-energy supersymmetric extensions of the SM. I'll explain why we have concrete hopes that this decade will shed definite light on what stands behind the phenomenon of electroweak symmetry breaking

  2. Nanomedicine highlights in atherosclerosis

    International Nuclear Information System (INIS)

    Karagkiozaki, Varvara

    2013-01-01

    Atherosclerosis is a multifactorial disease and many different approaches have been attempted for its accurate diagnosis and treatment. The disease is induced by a low-grade inflammatory process in the vascular wall, leading through a cascade of events to the eventual formation of atheromatous plaque and arterial stenosis. Different types of cells participate in the process making more difficult to recognize the potential cellular targets within the plaques for their effective treatment. The rise of nanomedicine over the last decade has provided new types of drug delivery nanosystems that are able to be delivered to a specific diseased site of the vessel for imaging while simultaneously act as therapeutic agents. In this paper, a review of the recent advances in nanomedicine that has provided novel insights to the disease diagnosis and treatment will be given in line with different nanotechnology-based approaches to advance the cardiovascular stents. The main complications of bare metal stents such as restenosis and of drug-eluting stents which is the late stent thrombosis are analyzed to comprehend the demand for emerging therapeutic strategies based on nanotechnology.

  3. Highlight on China

    Index Scriptorium Estoniae

    2007-01-01

    Eesti ja Hiina suhetest. Juttu on ka president Toomas Hendrik Ilvese 2006. a. oktoobris toimunud kohtumisest Hiina Rahva poliitilise konsultatiivkonverentsi rahvusliku komitee esimehe Jia Quinglingiga

  4. Highlights from D0

    International Nuclear Information System (INIS)

    Madaras, R.J.

    1992-12-01

    The D0 Experiment is a new, large multipurpose experiment at the Tevatron Proton-Antiproton Collider at the Fermi National Accelerator Laboratory. From the analysis of data taken during August--October, 1992, a selection of preliminary physics results will be given on inclusive jet production, direct photon production, the production and decay properties of the W and Z bosons, the search for the top quark in the dilepton and lepton + jets channels, B physics and searches for new particles

  5. Peripatetic Highlights in Bern

    Science.gov (United States)

    Hentschel, Ann M.

    The capital city of the Swiss Canton of Bern and of the Swiss Confederation is nestled in a narrow loop of the Aare river, at the foot of the Alps. The old town, founded around 1191, is well preserved despite a devastating fire in 1405.** Major industries of the region developed under the constraints of modest domestic markets, high transportation costs, and protectionist legislation across national borders. Switzerland thus found its niche in higher-end markets, such as chocolate making, engine building, instruments, fine textiles, and chemicals or pharmaceuticals. My tour past historically significant scientific sites in Bern will use the local legacy of its most illustrious residents, Albert Einstein (1879-1955), who lived there from 1902-1909, and Fritz Houtermans (1903-1966), who lived there from 1952-1966, as its guiding thread through the old town and the university district. Place names in italics mark stops along the tour.

  6. LISA system design highlights

    Energy Technology Data Exchange (ETDEWEB)

    Sallusti, M [European Space Agency, ESTEC, Keplerlaan 1, 2200 AG Noordwijk ZH (Netherlands); Gath, P; Weise, D; Berger, M; Schulte, H R, E-mail: marcello.sallusti@esa.in, E-mail: peter.gath@astrium.eads.ne, E-mail: dennis.weise@astrium.eads.ne, E-mail: marcel.berger@astrium.eads.ne, E-mail: Hans.Reiner.Schulte@astrium.eads.ne [Astrium GmbH Satellites, Claude-Dornier-Str., 88039 Friedrichshafen (Germany)

    2009-05-07

    A contract, started in January 2005, was awarded to a consortium of Astrium GmbH and Astrium Ltd for the LISA Mission Formulation. The scope of the contract was the development of a reference design for the mission architecture and for the mission elements (with particular focus on the payload) and a successive phase of derivation of requirements, to be concluded with a mission design review. The technical starting point was the output of the previous LISA study formalized in the Final Technical Report, issued in the year 2000. During the design phase, different architecture concepts were identified and traded off, including the LISA orbits, the measurement scheme and the opto-mechanical architecture. During the Mission Design Review (July 2008) the consolidated mission baseline design, and the specifications of the flight elements and of the payload subsystem and major components were presented. This paper gives a brief overview of the major design points of the latest design of the LISA system.

  7. LISA system design highlights

    International Nuclear Information System (INIS)

    Sallusti, M; Gath, P; Weise, D; Berger, M; Schulte, H R

    2009-01-01

    A contract, started in January 2005, was awarded to a consortium of Astrium GmbH and Astrium Ltd for the LISA Mission Formulation. The scope of the contract was the development of a reference design for the mission architecture and for the mission elements (with particular focus on the payload) and a successive phase of derivation of requirements, to be concluded with a mission design review. The technical starting point was the output of the previous LISA study formalized in the Final Technical Report, issued in the year 2000. During the design phase, different architecture concepts were identified and traded off, including the LISA orbits, the measurement scheme and the opto-mechanical architecture. During the Mission Design Review (July 2008) the consolidated mission baseline design, and the specifications of the flight elements and of the payload subsystem and major components were presented. This paper gives a brief overview of the major design points of the latest design of the LISA system.

  8. 2016 ALCF Science Highlights

    Energy Technology Data Exchange (ETDEWEB)

    Collins, James R. [Argonne National Lab. (ANL), Argonne, IL (United States); Cerny, Beth A. [Argonne National Lab. (ANL), Argonne, IL (United States); Wolf, Laura [Argonne National Lab. (ANL), Argonne, IL (United States); Coffey, Richard M. [Argonne National Lab. (ANL), Argonne, IL (United States); Papka, Michael E. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-01-01

    The Argonne Leadership Computing Facility provides supercomputing capabilities to the scientific and engineering community to advance fundamental discovery and understanding in a broad range of disciplines.

  9. Highlights: Spring Council Meeting

    Science.gov (United States)

    Council members present at the May 24, 1981, meeting were Keiiti Aki, Steven Burges (for Jim Wallis), Peter S. Eagleson, E. R. Engdahl, Charles E. Helsley, James R. Heirtzler, Carl Kisslinger, Leslie H. Meredith, Chris N. K. Mooers, Norman F. Ness, Marcia M. Neugebauer, James J. O'Brien, Richard Rapp, Carl Sagan, James C. Savage, Joseph V. Smith, Fred Spilhaus, Donald L. Turcotte, James A. Van Allen, J. Tuzo Wilson, and Jay Winston (for Elmar R. Reiter until his arrival at 6:50 P.M.). David Strangway, representing the Canadian Geophysical Union, and Peter Steinhauser, representing the European Geophysical Society, were special observers at the meeting. Council meetings are open, and a number of section secretaries, committee chairmen, journal editors, and other members attended. The following major actions were adopted by the Council:The experiment of publishing oceanography and lower-atmosphere papers in JGR Green issues alternate to those containing upper-atmosphere papers will be continued through 1982. From preliminary indications the experiment seems to be working, but a full year of data, including a renewal cycle, is needed to assess the success of the experiment. Final decision will be made prior to the 1983 dues notices.

  10. ZGS highlights and speculations

    International Nuclear Information System (INIS)

    Fields, T.H.

    1979-01-01

    Several examples of unfinished business of the ZGS program are described. These examples cover physics, apparatus, and institutional subjects. Speculations are given about the evolution of these subjects during the 1980's

  11. Jobs Plan Highlights Education

    Science.gov (United States)

    Klein, Alyson

    2011-01-01

    President Barack Obama is putting new money to save educators' jobs and help states refurbish aging school facilities at the center of a nearly $450 billion plan to jump-start the sluggish economy. The author talks about the president's plan which is sure to face hurdles in a politically polarized Washington where one house of Congress is…

  12. 2012 Ground Testing Highlights

    Science.gov (United States)

    Buchholz, Steven J.

    2012-01-01

    As part of the Fundamental Aeronautics Program and a collaborative effort with Boeing, and Lockheed Martin this past year a series of sonic boom test were completed in the NASA Ames Unitary Plan Wind Tunnel (UPWT). One of the goals was to develop new test techniques and hardware for measuring sonic boom signatures in the transonic and supersonic regimes. Data for various model designs and configurations were collected and will be used to validate CFD predictions of sonic boom signatures. Reactivation of the NASA Ames Mitsubishi compressor system was completed this past year. The compressor is intended to replace and augment the existing UPWT Clark Compressor as the primary Make Up Air (MUA) source. The MUA system provides air and vacuum pumping capability to the Ames UPWT. It will improve productivity and reliability of the UPWT as a vital testing and research facility for the U.S. aerospace industry and NASA. Funding for this task was provided from the American Recovery Investment Act (ARRA). Installation and validation of a Noncontact Stress Monitoring System (NSMS) for the 3-stage compressor was completed at the 11-foot Transonic Wind Tunnel. The system, originally developed at AEDC, consists of 36 pairs of LED light sources with optic beam send and receive probes along a 1-per rev signal. The new system allows for continuous monitoring and recording of compressor blade bending and torsion stress during normal test operations. A very unusual test was completed in the 11 FT TWT to acquire aerodynamic and flow field data for the Crew Exploration Vehicle (CEV) Parachute Assembly System (CPAS) to validate CFD methods and tools. Surface pressure distribution measurements and velocity measurements in the wake of the command module back to the drogues parachute location were acquired. Testing methods included Particle Image Velocimetry (PIV), Pressure Sensitive Paint (PSP), Schlieren Infrared Imaging (IR) and boundary layer survey and skin friction.

  13. Energy in France. Highlights

    International Nuclear Information System (INIS)

    2002-01-01

    This document presents a selection of statistics (figures as of 30 April 2002) about: energy in the French economy, all energies, oil, gas, coal, electricity, renewable energies, district heating, rational use of energy, prices, energy and environment (CO 2 emissions). Data are presented in tables and graphs. (J.S.)

  14. Oil shale highlights

    International Nuclear Information System (INIS)

    1994-01-01

    The low prices of crude oil have continued to retard the commercial development of oil shale and other syn fuels. Although research funds are more difficult to find, some R and D work by industry, academia, and governmental agencies continues in the United States and in other parts of the world. Improvements in retorting technology, upgrading oil-shale feedstock, and developing high-value niche-market products from shale oil are three notable areas of research that have been prominent for the past several years. Although the future prices of conventional crude cannot be predicted, it seems evident that diminishing supplies and a burgeoning world population will force us to turn to alternate fossil fuels as well as to cleaner sources of non-fossil energy. (author)

  15. Brookhaven highlights 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    Established in 1947 on Long Island, New York, on the site of the former army Camp Upton, BNL is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical and environmental sciences and in selected energy technologies. The Laboratory is managed by Associated Universities, Inc., under contract to the US Department of Energy. BNL`s annual budget is about $400 million, and the Laboratory`s facilities are valued at replacements cost in excess of over $2.8 billion. Employees number around 3,300,and over 4,000 guests, collaborators and students come each year to use the Laboratory`s facilities and work with the staff. Scientific and technical achievements at BNL have made their way into daily life in areas as varied as health care, construction materials and video games. The backbone of these developments is fundamental research, which is and always will be an investment in the future.

  16. Highlights of the Workshop

    Science.gov (United States)

    Noor, Ahmed K.

    1997-01-01

    Economic stresses are forcing many industries to reduce cost and time-to-market, and to insert emerging technologies into their products. Engineers are asked to design faster, ever more complex systems. Hence, there is a need for novel design paradigms and effective design tools to reduce the design and development times. Several computational tools and facilities have been developed to support the design process. Some of these are described in subsequent presentations. The focus of the workshop is on the computational tools and facilities which have high potential for use in future design environment for aerospace systems. The outline for the introductory remarks is given. First, the characteristics and design drivers for future aerospace systems are outlined; second, simulation-based design environment, and some of its key modules are described; third, the vision for the next-generation design environment being planned by NASA, the UVA ACT Center and JPL is presented. The anticipated major benefits of the planned environment are listed; fourth, some of the government-supported programs related to simulation-based design are listed; and fifth, the objectives and format of the workshop are presented.

  17. Highlights of CP 2000

    CERN Document Server

    Ellis, John R.

    2001-01-01

    Various developing topics in CP violation are reviewed. There are many theoretical reasons to hope that the CKM paradigm may be incomplete. It is surely too soon to be claiming new physics in \\epsilon^\\prime/\\epsilon or in D^0-\\bar D^0 mixing, but rare K decays offer interesting places to search for new physics. It is probably also premature to see a clash between global CKM fits and current estimates of sin \\beta and \\gamma, where much more precise data will soon be available. There are interesting possibilities to look for CP violation in neutrino oscillations and in Higgs physics. Rapid progress can be expected now that CP violation is moving to the top of the particle physics agenda.

  18. BARC highlights 86

    International Nuclear Information System (INIS)

    1987-01-01

    The Bhabha Atomic Research Centre (BARC), Bombay, is the premier multidisciplinary research establishment of the Department of Atomic Energy (India). It provides Research and Development (R and D) support to the nuclear programmes of the country. Some of its important R and D activities and achievements during 1986 are described in brief in the chapters entitled: Physical Sciences, Chemical Sciences, Materials and Materials Sciences, Life Sciences, Reactors, Fuel Cycle, and Electronics and Instrumentation. The entire text is illustrated with a number of diagrams and photographs. (M.G.B.)

  19. Nanomedicine highlights in atherosclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Karagkiozaki, Varvara, E-mail: vakaragk@physics.auth.gr [Aristotle University of Thessaloniki, Nanomedicine Group, Laboratory for Thin Films-Nanosystems and Nanometrology (LTFN), Physics Department (Greece)

    2013-04-15

    Atherosclerosis is a multifactorial disease and many different approaches have been attempted for its accurate diagnosis and treatment. The disease is induced by a low-grade inflammatory process in the vascular wall, leading through a cascade of events to the eventual formation of atheromatous plaque and arterial stenosis. Different types of cells participate in the process making more difficult to recognize the potential cellular targets within the plaques for their effective treatment. The rise of nanomedicine over the last decade has provided new types of drug delivery nanosystems that are able to be delivered to a specific diseased site of the vessel for imaging while simultaneously act as therapeutic agents. In this paper, a review of the recent advances in nanomedicine that has provided novel insights to the disease diagnosis and treatment will be given in line with different nanotechnology-based approaches to advance the cardiovascular stents. The main complications of bare metal stents such as restenosis and of drug-eluting stents which is the late stent thrombosis are analyzed to comprehend the demand for emerging therapeutic strategies based on nanotechnology.

  20. CAM Highlights (FY 80)

    Science.gov (United States)

    1980-10-01

    industrialized nations in almost every manufacturing market place. Many foreign nation’s manu- facturing advancements have resulted from...several computer languages available on the market to program numerically controlled machine tools. However, there was a need for a docu- ment showing...by contacting Mr. Richard Kotler , MICOM, Autovon 746-2065 or Commercial (205) 876-2065. 56 600 MANUFACTURING CONTROL Factory Management Control