Sample records for achieve rapid modulation

  1. Plant MAPK cascades: Just rapid signaling modules?

    KAUST Repository

    Boudsocq, Marie


    © 2015 Taylor & Francis Group, LLC. Abscisic acid (ABA) is a major phytohormone mediating important stress-related processes. We recently unveiled an ABA-activated MAPK signaling module constituted of MAP3K17/18-MKK3-MPK1/2/7/14. Unlike classical rapid MAPK activation, we showed that the activation of the new MAPK module is delayed and relies on the MAP3K protein synthesis. In this addendum, we discuss the role of this original and unexpected activation mechanism of MAPK cascades which suggests that MAPKs can regulate both early and longterm plant stress responses.

  2. Rapid Prototyping Modules for Remote Engineering Applications

    Directory of Open Access Journals (Sweden)

    Karsten Henke


    Full Text Available This contribution describes the concept and implementation for an integration of microcontroller and FPGA based Rapid Prototyping modules into a Remote Lab system. This implementation enables a Web-based access to electro-mechanical models. A student uploads a source file implementation to the Remote Lab server in order to test an implementation directly within a hardware environment. The Remote Lab server offers the interfaces to integrate specific project and hardware plug-ins. These plug-ins access a hardware specific software environment to automatically compile and program the resulting firmware. To stimulate this design, the Remote Lab server exchanges digital signals via a serial interface. To allow the student to compare architectures of different designs using the same hardware model, a specific controller (using the Remote Lab interface can be selected. For this, an IP-based multiplexer provides the control connection between the respective controller and the hardware model. In our contribution we would like to give examples of such a complex design task and how the students can use different tools during several design steps.

  3. Capacity Achieving Modulation for Fixed Constellations with Average Power Constraint

    CERN Document Server

    Bocherer, Georg; Mathar, Rudolf


    The capacity achieving probability mass function (PMF) of a finite signal constellation with an average power constraint is in most cases non-uniform. A common approach to generate non-uniform input PMFs is Huffman shaping, which consists of first approximating the capacity achieving PMF by a sampled Gaussian density and then to calculate the Huffman code of the sampled Gaussian density. The Huffman code is then used as a prefix-free modulation code. This approach showed good results in practice, can however lead to a significant gap to capacity. In this work, a method is proposed that efficiently constructs optimal prefix-free modulation codes for any finite signal constellation with average power constraint in additive noise. The proposed codes operate as close to capacity as desired. The major part of this work elaborates an analytical proof of this property. The proposed method is applied to 64-QAM in AWGN and numeric results are given, which show that, opposed to Huffman shaping, by using the proposed me...

  4. Rapid Speed Modulation of a Rotary Total Artificial Heart Impeller. (United States)

    Kleinheyer, Matthias; Timms, Daniel L; Tansley, Geoffrey D; Nestler, Frank; Greatrex, Nicholas A; Frazier, O Howard; Cohn, William E


    Unlike the earlier reciprocating volume displacement-type pumps, rotary blood pumps (RBPs) typically operate at a constant rotational speed and produce continuous outflow. When RBP technology is used in constructing a total artificial heart (TAH), the pressure waveform that the TAH produces is flat, without the rise and fall associated with a normal arterial pulse. Several studies have suggested that pulseless circulation may impair microcirculatory perfusion and the autoregulatory response and may contribute to adverse events such as gastrointestinal bleeding, arteriovenous malformations, and pump thrombosis. It may therefore be beneficial to attempt to reproduce pulsatile output, similar to that generated by the native heart, by rapidly modulating the speed of an RBP impeller. The choice of an appropriate speed profile and control strategy to generate physiologic waveforms while minimizing power consumption and blood trauma becomes a challenge. In this study, pump operation modes with six different speed profiles using the BiVACOR TAH were evaluated in vitro. These modes were compared with respect to: hemodynamic pulsatility, which was quantified as surplus hemodynamic energy (SHE); maximum rate of change of pressure (dP/dt); pulse power index; and motor power consumption as a function of pulse pressure. The results showed that the evaluated variables underwent different trends in response to changes in the speed profile shape. The findings indicated a possible trade-off between SHE levels and flow rate pulsatility related to the relative systolic duration in the speed profile. Furthermore, none of the evaluated measures was sufficient to fully characterize hemodynamic pulsatility.

  5. Rapid, Time-Division Multiplexed, Direct Absorption- and Wavelength Modulation-Spectroscopy

    Directory of Open Access Journals (Sweden)

    Alexander Klein


    Full Text Available We present a tunable diode laser spectrometer with a novel, rapid time multiplexed direct absorption- and wavelength modulation-spectroscopy operation mode. The new technique allows enhancing the precision and dynamic range of a tunable diode laser absorption spectrometer without sacrificing accuracy. The spectroscopic technique combines the benefits of absolute concentration measurements using calibration-free direct tunable diode laser absorption spectroscopy (dTDLAS with the enhanced noise rejection of wavelength modulation spectroscopy (WMS. In this work we demonstrate for the first time a 125 Hz time division multiplexed (TDM-dTDLAS-WMS spectroscopic scheme by alternating the modulation of a DFB-laser between a triangle-ramp (dTDLAS and an additional 20 kHz sinusoidal modulation (WMS. The absolute concentration measurement via the dTDLAS-technique allows one to simultaneously calibrate the normalized 2f/1f-signal of the WMS-technique. A dTDLAS/WMS-spectrometer at 1.37 µm for H2O detection was built for experimental validation of the multiplexing scheme over a concentration range from 50 to 3000 ppmV (0.1 MPa, 293 K. A precision of 190 ppbV was achieved with an absorption length of 12.7 cm and an averaging time of two seconds. Our results show a five-fold improvement in precision over the entire concentration range and a significantly decreased averaging time of the spectrometer.

  6. Thermally moderated hollow fiber sorbent modules in rapidly cycled pressure swing adsorption mode for hydrogen purification

    KAUST Repository

    Lively, Ryan P.


    We describe thermally moderated multi-layered pseudo-monolithic hollow fiber sorbents entities, which can be packed into compact modules to provide small-footprint, efficient H2 purification/CO2 removal systems for use in on-site steam methane reformer product gas separations. Dual-layer hollow fibers are created via dry-jet, wet-quench spinning with an inner "active" core of cellulose acetate (porous binder) and zeolite NaY (69 wt% zeolite NaY) and an external sheath layer of pure cellulose acetate. The co-spun sheath layer reduces the surface porosity of the fiber and was used as a smooth coating surface for a poly(vinyl-alcohol) post-treatment, which reduced the gas permeance through the fiber sorbent by at least 7 orders of magnitude, essentially creating an impermeable sheath layer. The interstitial volume between the individual fibers was filled with a thermally-moderating paraffin wax. CO2 breakthrough experiments on the hollow fiber sorbent modules with and without paraffin wax revealed that the "passively" cooled paraffin wax module had 12.5% longer breakthrough times than the "non-isothermal" module. The latent heat of fusion/melting of the wax offsets the released latent heat of sorption/desorption of the zeolites. One-hundred rapidly cycled pressure swing adsorption cycles were performed on the "passively" cooled hollow fiber sorbents using 25 vol% CO2/75 vol% He (H2 surrogate) at 60 °C and 113 psia, resulting in a product purity of 99.2% and a product recovery of 88.1% thus achieving process conditions and product quality comparable to conventional pellet processes. Isothermal and non-isothermal dynamic modeling of the hollow fiber sorbent module and a traditional packed bed using gPROMS® indicated that the fiber sorbents have sharper fronts (232% sharper) and longer adsorbate breakthrough times (66% longer), further confirming the applicability of the new fiber sorbent approach for H2 purification. © 2012, Hydrogen Energy Publications, LLC

  7. Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit (United States)

    Chao, Michael Y.; Komatsu, Hidetoshi; Fukuto, Hana S.; Dionne, Heather M.; Hart, Anne C.


    Serotonin (5-HT) modulates synaptic efficacy in the nervous system of vertebrates and invertebrates. In the nematode Caenorhabditis elegans, many behaviors are regulated by 5-HT levels, which are in turn regulated by the presence or absence of food. Here, we show that both food and 5-HT signaling modulate chemosensory avoidance response of octanol in C. elegans, and that this modulation is both rapid and reversible. Sensitivity to octanol is decreased when animals are off food or when 5-HT levels are decreased; conversely, sensitivity is increased when animals are on food or have increased 5-HT signaling. Laser microsurgery and behavioral experiments reveal that sensory input from different subsets of octanol-sensing neurons is selectively used, depending on stimulus strength, feeding status, and 5-HT levels. 5-HT directly targets at least one pair of sensory neurons, and 5-HT signaling requires the G protein GPA-11. Glutamatergic signaling is required for response to octanol, and the GLR-1 glutamate receptor plays an important role in behavioral response off food but not on food. Our results demonstrate that 5-HT modulation of neuronal activity via G protein signaling underlies behavioral plasticity by rapidly altering the functional circuitry of a chemosensory circuit.

  8. Fiber Attachment Module Experiment (FAME): Using a Multiplexed Miniature Hollow Fiber Membrane Bioreactor Solution for Rapid Process Testing (United States)

    Lunn, Griffin; Wheeler, Raymond; Hummerick, Mary; Birmele, Michele; Richards, Jeffrey; Coutts, Janelle; Koss, Lawrence; Spencer, Lashelle.; Johnsey, Marissa; Ellis, Ronald

    Bioreactor research, even today, is mostly limited to continuous stirred-tank reactors (CSTRs). These are not an option for microgravity applications due to the lack of a gravity gradient to drive aeration as described by the Archimedes principle. This has led to testing of Hollow Fiber Membrane Bioreactors (HFMBs) for microgravity applications, including possible use for wastewater treatment systems for the International Space Station (ISS). Bioreactors and filtration systems for treating wastewater could avoid the need for harsh pretreatment chemicals and improve overall water recovery. However, the construction of these reactors is difficult and commercial off-the-shelf (COTS) versions do not exist in small sizes. We have used 1-L modular HFMBs in the past, but the need to perform rapid testing has led us to consider even smaller systems. To address this, we designed and built 125-mL, rectangular reactors, which we have called the Fiber Attachment Module Experiment (FAME) system. A polycarbonate rack of four square modules was developed with each module containing removable hollow fibers. Each FAME reactor is self-contained and can be easily plumbed with peristaltic and syringe pumps for continuous recycling of fluids and feeding, as well as fitted with sensors for monitoring pH, dissolved oxygen, and gas measurements similar to their larger counterparts. The first application tested in the FAME racks allowed analysis of over a dozen fiber surface treatments and three inoculation sources to achieve rapid reactor startup and biofilm attachment (based on carbon oxidation and nitrification of wastewater). With these miniature FAME reactors, data for this multi-factorial test were collected in duplicate over a six-month period; this greatly compressed time period required for gathering data needed to study and improve bioreactor performance.

  9. Wound healing ability of Xenopus laevis embryos. I. Rapid wound closure achieved by bisectional half embryos. (United States)

    Yoshii, Yasuko; Noda, Masahiro; Matsuzaki, Takashi; Ihara, Setsunosuke


    We examined wound closure in 'half embryos' produced by the transverse bisection of Xenopus laevis embryos at the primary eye vesicle stage. Both the anterior- and posterior-half embryos survived for more than 6 days, and grew into 'half tadpoles'. Histology and videomicroscopy revealed that the open wound in the half embryo was rapidly closed by an epithelial sheet movement in the wound marginal zone. The time-course of wound closure showed a downward convex curve: the wound area decreased to one-fifth of the original area within 30 min, and the wound continued to contract slowly thereafter. The rapidity of closure of the epidermis as well as the absence of inflammatory cells are typical features of an embryonic type of wound healing. There was a dorso-ventral polarity in the motility of the epidermis: the wound was predominantly closed by the ventral and lateral epidermis. The change in the contour of the wound edge with time suggested a complex mechanism involved in the wound closure that could not be explained only by the purse-string theory. The present experimental system would be a unique and useful model for analyses of cellular movements in the embryonic epithelia.

  10. A Rapid Method to Achieve Aero-Engine Blade Form Detection

    Directory of Open Access Journals (Sweden)

    Bin Sun


    Full Text Available This paper proposes a rapid method to detect aero-engine blade form, according to the characteristics of an aero-engine blade surface. This method first deduces an inclination error model in free-form surface measurements based on the non-contact laser triangulation principle. Then a four-coordinate measuring system was independently developed, a special fixture was designed according to the blade shape features, and a fast measurement of the blade features path was planned. Finally, by using the inclination error model for correction of acquired data, the measurement error that was caused by tilt form is compensated. As a result the measurement accuracy of the Laser Displacement Sensor was less than 10 μm. After the experimental verification, this method makes full use of optical non-contact measurement fast speed, high precision and wide measuring range of features. Using a standard gauge block as a measurement reference, the coordinate system conversion data is simple and practical. It not only improves the measurement accuracy of the blade surface, but also its measurement efficiency. Therefore, this method increases the value of the measurement of complex surfaces.


    Directory of Open Access Journals (Sweden)

    Rajanikant C. Patel


    Full Text Available Furosemide, a weekly acidic, loop diuretic drug indicated for treatment of edema and hypertension having high permeability through stomach. It is practically insoluble in gastric fluid (0.006 mg/mL and having highly permeability through stomach but due to its solubility limitation it can’t enter into systemic circulation. It was logically decided to design experiment, so as to achieve the set objectives. Attempt was made to prepare solid dispersion of furosemide with Poly ethylene glycol (PEG 6000 containing microcrystalline cellulose (MCC as adsorbent which would dissolve completely in less than 30 minutes (target selected by considering minimum gastric empting time. Microcrystalline cellulose converted sticky dispersion in to free flow powder hence increase surface area which responsible for dissolution improvement. Factorial design was applied to optimize formulation. Amount of poly ethylene glycol 6000 and microcrystalline cellulose were selected as an Independent variable while angle of repose and T100% were selected as dependent variable. Attempts for dissolution rate of furosemide improve bioavailability and consequently dose reduction would possible.

  12. Modulation Methods for Three-level Neutral-Point-Clamped Inverter Achieving Stress Redistribution under Moderate Modulation Index

    DEFF Research Database (Denmark)

    Ma, Ke; Blaabjerg, Frede


    This letter investigates the loss and thermal behaviors of a three-level neutral-point-clamped (3L-NPC) inverter undergoing moderate modulation index, which is typically presented during minor voltage sags of the power grid or speed changes of the electric machines. A series of new space vector m...

  13. Experimental Demonstration of Capacity-Achieving Phase-Shifted Superposition Modulation

    DEFF Research Database (Denmark)

    Estaran Tolosa, Jose Manuel; Zibar, Darko; Caballero Jambrina, Antonio


    We report on the first experimental demonstration of phase-shifted superposition modulation (PSM) for optical links. Successful demodulation and decoding is obtained after 240 km transmission for 16-, 32- and 64-PSM.......We report on the first experimental demonstration of phase-shifted superposition modulation (PSM) for optical links. Successful demodulation and decoding is obtained after 240 km transmission for 16-, 32- and 64-PSM....

  14. Response selection difficulty modulates the behavioral impact of rapidly learnt action effects.

    Directory of Open Access Journals (Sweden)

    Uta eWolfensteller


    Full Text Available It is well established that we can pick up action effect associations when acting in a free-choice intentional mode. However, it is less clear whether and when action effect associations are learnt and actually affect behavior if we are acting in a forced-choice mode, applying a specific stimulus-response (S-R rule. In the present study, we investigated whether response selection difficulty imposed by S-R rules influences the initial rapid learning and the behavioral expression of previously learnt but weakly practiced action effect associations when those are re-activated by effect exposure. Experiment 1 showed that the rapid acquisition of action effect associations is not directly influenced by response selection difficulty. By contrast, the behavioral expression of re-activated action effect associations is prevented when actions are directly activated by highly over-learnt response cues and thus response selection difficulty is low. However, all three experiments showed that if response selection difficulty is sufficiently high during re-activation, the same action effect associations do influence behavior. Experiment 2 and 3 revealed that the effect of response selection difficulty cannot be fully reduced to giving action effects more time to prime an action, but seems to reflect competition during response selection. Finally, the present data suggest that when multiple novel rules are rapidly learnt in succession, which requires a lot of flexibility, action effect associations continue to influence behavior only if response selection difficulty is sufficiently high. Thus, response selection difficulty might modulate the impact of experiencing multiple learning episodes on action effect expression and learning, possibly via inducing different strategies.

  15. Energy-Level Modulation of Small-Molecule Electron Acceptors to Achieve over 12% Efficiency in Polymer Solar Cells. (United States)

    Li, Sunsun; Ye, Long; Zhao, Wenchao; Zhang, Shaoqing; Mukherjee, Subhrangsu; Ade, Harald; Hou, Jianhui


    Fine energy-level modulations of small-molecule acceptors (SMAs) are realized via subtle chemical modifications on strong electron-withdrawing end-groups. The two new SMAs (IT-M and IT-DM) end-capped by methyl-modified dicycanovinylindan-1-one exhibit upshifted lowest unoccupied molecular orbital (LUMO) levels, and hence higher open-circuit voltages can be observed in the corresponding devices. Finally, a top power conversion efficiency of 12.05% is achieved.

  16. Achievable Rates for Four-Dimensional Coded Modulation with a Bit-Wise Receiver

    CERN Document Server

    Alvarado, Alex


    We study achievable rates for four-dimensional (4D) constellations for spectrally efficient optical systems based on a (suboptimal) bit-wise receiver. We show that PM-QPSK outperforms the best 4D constellation designed for uncoded transmission by approximately 1 dB. Numerical results using LDPC codes validate the analysis.

  17. Rapid evolution of plethodontid modulating factor, a hypervariable salamander courtship pheromone, is driven by positive selection. (United States)

    Palmer, Catherine A; Watts, Richard A; Hastings, Amy P; Houck, Lynne D; Arnold, Stevan J


    Sexual communication in plethodontid salamanders is mediated by a proteinaceous pheromone that a male delivers to a female during courtship, boosting her receptivity. The pheromone consists of three proteins from three unrelated protein families. These proteins are among a small group of pheromones known to affect female receptivity in vertebrates. Previously, we showed that the genes of two of these proteins (PRF and SPF) are prone to incessant evolution driven by positive selection, presumably as a consequence of coevolution with female receptors. In this report, we focus on the evolution of the third pheromone protein gene family, plethodontid modulating factor (PMF), to determine whether it shows the same pattern of diversification. We used RT-PCR in mental gland cDNA to survey PMF sequences from three genera of plethodontid salamanders (27 spp.) to measure rates of evolution, level of gene diversification, modes of selection, and types of amino acid substitution. Like PRF and SPF, PMF is produced by a multigene family characterized by gene duplication and high levels of polymorphism. PMF evolution is rapid, incessant, and driven by positive selection. PMF is more extreme in these dimensions than both PRF and SPF. Nestled within this extraordinary variation, however, is a signature of purifying selection, acting to preserve important structural and biochemical features of the PMF protein (i.e., secretion signal, cysteine residues, and pI). Although a pattern of persistent diversification exists at the molecular level, the morphological and behavioral aspects of the pheromone delivery system show evolutionary stasis over millions of years.

  18. RapidArc volumetric modulated therapy planning for prostate cancer patients

    DEFF Research Database (Denmark)

    Kjaer-Kristoffersen, Flemming; Ohlhues, Lars; Medin, Joakim


    PURPOSE: Recently, Varian Medical Systems have announced the introduction of a new treatment technique, RapidArc, in which dose is delivered over a single gantry rotation with dynamically variable MLC positions, dose rate and gantry speed. At Rigshospitalet, the RapidArc technique was brought int...

  19. A Survey of Hardware and Software Technologies for the Rapid Development of Multimedia Instructional Modules (United States)

    Ganesan, Nanda


    A survey of hardware and software technologies was conducted to identify suitable technologies for the development of instructional modules representing various instructional approaches. The approaches modeled were short PowerPoint presentations, chalk-and-talk type of lectures and software tutorials. The survey focused on identifying application…

  20. The GLAaS algorithm for portal dosimetry and quality assurance of RapidArc, an intensity modulated rotational therapy

    Directory of Open Access Journals (Sweden)

    Fogliata Antonella


    Full Text Available Abstract Background To expand and test the dosimetric procedure, known as GLAaS, for amorphous silicon detectors to the RapidArc intensity modulated arc delivery with Varian infrastructures and to test the RapidArc dosimetric reliability between calculation and delivery. Methods The GLAaS algorithm was applied and tested on a set of RapidArc fields at both low (6 MV and high (18 MV beam energies with a PV-aS1000 detector. Pilot tests for short arcs were performed on a 6 MV beam associated to a PV-aS500. RapidArc is a novel planning and delivery method in the category of intensity modulated arc therapies aiming to deliver highly modulated plans with variable MLC shapes, dose rate and gantry speed during rotation. Tests were repeated for entire (360 degrees gantry rotations on composite dose plans and for short partial arcs (of ~6 or 12 degrees to assess GLAaS and RapidArc mutual relationships on global and fine delivery scales. The gamma index concept of Low and the Modulation Index concept of Webb were applied to compare quantitatively TPS dose matrices and dose converted PV images. Results The Gamma Agreement Index computed for a Distance to Agreement of 3 mm and a Dose Difference (ΔD of 3% was, as mean ± 1 SD, 96.7 ± 1.2% at 6 MV and 94.9 ± 1.3% at 18 MV, over the field area. These findings deteriorated slightly is ΔD was reduced to 2% (93.4 ± 3.2% and 90.1 ± 3.1%, respectively and improved with ΔD = 4% (98.3 ± 0.8% and 97.3 ± 0.9%, respectively. For all tests a grid of 1 mm and the AAA photon dose calculation algorithm were applied. The spatial resolution of the PV-aS1000 is 0.392 mm/pxl. The Modulation Index for calculations resulted 17.0 ± 3.2 at 6 MV and 15.3 ± 2.7 at 18 MV while the corresponding data for measurements were: 18.5 ± 3.7 and 17.5 ± 3.7. Partial arcs findings were (for ΔD = 3%: GAI = 96.7 ± 0.9% for 6° rotations and 98.0 ± 1.1% for 12° rotations. Conclusion The GLAaS method can be considered as a valid

  1. Rapid wide-field Mueller matrix polarimetry imaging based on four photoelastic modulators with no moving parts. (United States)

    Alali, Sanaz; Gribble, Adam; Vitkin, I Alex


    A new polarimetry method is demonstrated to image the entire Mueller matrix of a turbid sample using four photoelastic modulators (PEMs) and a charge coupled device (CCD) camera, with no moving parts. Accurate wide-field imaging is enabled with a field-programmable gate array (FPGA) optical gating technique and an evolutionary algorithm (EA) that optimizes imaging times. This technique accurately and rapidly measured the Mueller matrices of air, polarization elements, and turbid phantoms. The system should prove advantageous for Mueller matrix analysis of turbid samples (e.g., biological tissues) over large fields of view, in less than a second.

  2. Rapid and noncontact photoacoustic tomography imaging system using an interferometer with high-speed phase modulation technique

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Jun [School of Physics and Telecom Engineering, South China Normal University, Guangzhou 510006 (China); Tang, Zhilie; Wu, Yongbo [School of Physics and Telecom Engineering, South China Normal University, Guangzhou 510006 (China); GuangDong Province Key Laboratory of Quantum Engineering and Quantum Materials, South China Normal University, IMOT, Guangzhou 510006 (China); Wang, Yi [School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004 (China)


    We designed, fabricated, and tested a rapid and noncontact photoacoustic tomography (PAT) imaging system using a low-coherence interferometer with high-speed phase modulation technique. Such a rapid and noncontact probing system can greatly decrease the time of imaging. The proposed PAT imaging system is experimentally verified by capturing images of a simulated tissue sample and the blood vessels within the ear flap of a mouse (pinna) in vivo. The axial and lateral resolutions of the system are evaluated at 45 and ∼15 μm, respectively. The imaging depth of the system is 1 mm in a special phantom. Our results show that the proposed system opens a promising way to realize noncontact, real-time PAT.

  3. Rapid determination of Faraday rotation in optical glasses by means of secondary Faraday modulator. (United States)

    Sofronie, M; Elisa, M; Sava, B A; Boroica, L; Valeanu, M; Kuncser, V


    A rapid high sensitive method for determining the Faraday rotation of optical glasses is proposed. Starting from an experimental setup based on a Faraday rod coupled to a lock-in amplifier in the detection chain, two methodologies were developed for providing reliable results on samples presenting low and large Faraday rotations. The proposed methodologies were critically discussed and compared, via results obtained in transmission geometry, on a new series of aluminophosphate glasses with or without rare-earth doping ions. An example on how the method can be used for a rapid examination of the optical homogeneity of the sample with respect to magneto-optical effects is also provided.

  4. Priming from Distractors in Rapid Serial Visual Presentation Is Modulated by Image Properties and Attention (United States)

    Harris, Irina M.; Benito, Claire T.; Dux, Paul E.


    We investigated distractor processing in a dual-target rapid serial visual presentation (RSVP) task containing familiar objects, by measuring repetition priming from a priming distractor (PD) to Target 2 (T2). Priming from a visually identical PD was contrasted with priming from a PD in a different orientation from T2. We also tested the effect of…

  5. System design of programmable 4f phase modulation techniques for rapid intensity shaping: a conceptual comparison (United States)

    Roth, Matthias; Heber, Jörg; Janschek, Klaus


    The present study analyses three beam shaping approaches with respect to a light-efficient generation of i) patterns and ii) multiple spots by means of a generic optical 4f-setup. 4f approaches share the property that due to the one-to-one relationship between output intensity and input phase, the need for time-consuming, iterative calculation can be avoided. The resulting low computational complexity offers a particular advantage compared to the widely used holographic principles and makes them potential candidates for real-time applications. The increasing availability of high-speed phase modulators, e.g. on the basis of MEMS, calls for an evaluation of the performances of these concepts. Our second interest is the applicability of 4f methods to high-power applications. We discuss the variants of 4f intensity shaping by phase modulation from a system-level point of view which requires the consideration of application relevant boundary conditions. The discussion includes i) the micro mirror based phase manipulation combined with amplitude masking in the Fourier plane, ii) the Generalized Phase Contrast, and iii) matched phase-only correlation filtering combined with GPC. The conceptual comparison relies on comparative figures of merit for energy efficiency, pattern homogeneity, pattern image quality, maximum output intensity and flexibility with respect to the displayable pattern. Numerical simulations illustrate our findings.

  6. RapidArc radiotherapy planning for prostate cancer: Single-arc and double-arc techniques vs. intensity-modulated radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Sze, Henry C.K., E-mail: [Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong (Hong Kong); Lee, Michael C.H.; Hung, Wai-Man; Yau, Tsz-Kok; Lee, Anne W.M. [Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong (Hong Kong)


    RapidArc is a novel technique using arc radiotherapy aiming to achieve intensity-modulated radiotherapy (IMRT)-quality radiotherapy plans with shorter treatment time. This study compared the dosimetric quality and treatment efficiency of single-arc (SA) vs. double-arc (DA) and IMRT in the treatment of prostate cancer. Fourteen patients were included in the analysis. The planning target volume (PTV), which contained the prostate gland and proximal seminal vesicles, received 76 Gy in 38 fractions. Seven-field IMRT, SA, and DA plans were generated for each patient. Dosimetric quality in terms of the minimum PTV dose, PTV hotspot, inhomogeneity, and conformity index; and sparing of rectum, bladder, and femoral heads as measured by V70, V-40, and V20 (% of volume receiving >70 Gy, 40 Gy, and 20 Gy, respectively), treatment efficiency as assessed by monitor units (MU) and treatment time were compared. All plan objectives were met satisfactorily by all techniques. DA achieved the best dosimetric quality with the highest minimum PTV dose, lowest hotspot, and the best homogeneity and conformity. It was also more efficient than IMRT. SA achieved the highest treatment efficiency with the lowest MU and shortest treatment time. The mean treatment time for a 2-Gy fraction was 4.80 min, 2.78 min, and 1.30 min for IMRT, DA, and SA, respectively. However, SA also resulted in the highest rectal dose. DA could improve target volume coverage and reduce treatment time and MU while maintaining equivalent normal tissue sparing when compared with IMRT. SA achieved the greatest treatment efficiency but with the highest rectal dose, which was nonetheless within tolerable limits. For busy units with high patient throughput, SA could be an acceptable option.

  7. Phase space modulation method for EPID-based Monte Carlo dosimetry of IMRT and RapidArc plans

    Energy Technology Data Exchange (ETDEWEB)

    Berman, Avery; Townson, Reid; Bush, Karl; Zavgorodni, Sergei, E-mail: szavgorodni@bccancer.bc.c


    Quality assurance for IMRT and VMAT require 3D evaluation of the dose distributions from the treatment planning system as compared to the distributions reconstructed from signals acquired during the plan delivery. This study presents the results of the dose reconstruction based on a novel method of Monte Carlo (MC) phase space modulation. Typically, in MC dose calculations the linear accelerator (linac) is modelled for each field in the plan and a phase space file (PSF) containing all relevant particle information is written for each field. Particles from the PSFs are then used in the dose calculation. This study investigates a method of omitting the modelling of the linac in cases where the treatment has been measured by an electronic portal imaging device. In this method each portal image is deconvolved using an empirically fit scatter kernel to obtain the primary photon fluence. The Phase Space Modulation (PSM) method consists of simulating the linac just once to create a large PSF for an open field and then modulating it using the delivered primary particle fluence. Reconstructed dose distributions in phantoms were produced using MC and the modulated PSFs. The kernel derived for this method accurately reproduced the dose distributions for 3x3, 10x10, and 15x15 cm{sup 2} field sizes (mean relative dose-difference along the beam central axis is under 1%). The method has been applied to IMRT pre-treatment verification of 10 patients (including one RapidArc{sup TM} case), mean dose in the structures of interest agreed with that calculated by MC directly within 1%, and 95% of the voxels passed 2%/2mm criteria.

  8. Modulation of vagal activity to atria electrical remodeling resulted from rapid atrial pacing

    Institute of Scientific and Technical Information of China (English)

    Shulong Zhang; Yanzong Yang; Yingxue Dong; Lianjun Gao; Donghui Yang; Chunyue Zhao; Hongwei Zhao; Xiaomeng Yin; Jinqiu Liu; Zhihu Lin


    Background Atrial electrical remodeling(AER)plays an important role in the pathogenesis and maintenance of atrialfibrillation.However,little is known about modulation of vagal activilty to AER.This study aimed to investigate the relationshipbetween vagal moduation and AER. Methods Twenty four adult mongrel dogs under general anesthesia were randomized into 3groups.Sympathetic activity was blocked by administration of metoprolol in 3 groups.The changes in vagal modulation to atria afterAER were observed in 10 dogs without vagal interruption in group A.The effects of vagal intervention on AER were investigated in 8dogs with administration of atropine in group B.The impact of aggressively vagal activity on AER was studied in 6 dogs with bilateralcervical vag sympathetic trunLks stimulation during AER in group C.Bilateral cervicall vagosympathetic trunks were decentralized.Multipolar catheters wereplaced into high right atria(RA),coronary sinus(CS)and rightventricle(RV).AER was induced by 600 bpmpacing through RA catheter for 30 minutes.Attial effective refractory period(ERP)and vulnerability window (VW)of atrial fibrillationwere measured with and without vagal stimulation before and after AER.Results In group A,ERP decreased significantly at baselineand during vagal stimulation after AER compared with that beforeAER(all P<0.05).In group B,ERP remaind unchanged at baselineand vagal stimulation after AER compared with tbat before AER (all P>0.05).In group C,ERP shortened significantly at baseline andvagal stimulation after AER compared with that before AER(all P<0.05).ERP shortening after AER in Groups A and C increasedsignificantly than that in group B (all P<0.05).Atrial fibrillation could not be induced at baseline(VW close to 0) before and after AERin three groups.VW became widen significantly during vagal stimulation after AER compared with that before AER in Groups A and C(all P<0.05),while VW remained unchanged in group B (VW close to 0).Conclusions

  9. Rapid full Mueller matrix imaging polarimetry based on the hybrid phase modulation technique (United States)

    Han, Chien-Yuan; Du, Cheng-You; Jhou, Jhe-Yi


    In this work, we present a novel method of Mueller matrix imaging polarimetry, which comprises dual liquid crystal variable retarders at the polarization generation portion and a photoelastic modulator at the polarization analysis portion. The light source can be operated either in the continuous mode, which provides an in-situ calibration process for the liquid crystal variable retarders, or in the pulse mode to deduce the full two-dimensional Mueller matrix with 16 images from the camera. We measured the Mueller matrix images of air as a standard test, as well as a quarter wave plate to determine its azimuthal angle and phase retardation by the polar decomposition technique. Finally, the decomposed Mueller matrix images of a biopolymer specimen with the conformational change produced by heat treatment are presented.

  10. Cutting Edge: Murine Mast Cells Rapidly Modulate Metabolic Pathways Essential for Distinct Effector Functions. (United States)

    Phong, Binh; Avery, Lyndsay; Menk, Ashley V; Delgoffe, Greg M; Kane, Lawrence P


    There is growing appreciation that cellular metabolic and bioenergetic pathways do not play merely passive roles in activated leukocytes. Rather, metabolism has important roles in controlling cellular activation, differentiation, survival, and effector function. Much of this work has been performed in T cells; however, there is still very little information regarding mast cell metabolic reprogramming and its effect on cellular function. Mast cells perform important barrier functions and help control type 2 immune responses. In this study we show that murine bone marrow-derived mast cells rapidly alter their metabolism in response to stimulation through the FcεRI. We also demonstrate that specific metabolic pathways appear to be differentially required for the control of mast cell function. Manipulation of metabolic pathways may represent a novel point for the manipulation of mast cell activation.

  11. The Effect of Educational Modules Strategy on the Direct and Postponed Study's Achievement of Seventh Primary Grade Students in Science, in Comparison with the Conventional Approach (United States)

    Alelaimat, Abeer Rashed; Ghoneem, Khowla Abd Al Raheem


    This study aimed at revealing the effect of educational modules strategy on the direct and postponed study's achievement of seventh primary grade students in science, in comparison with the conventional approach. The sample of the study consists of (174) male and female students randomly chosen from schools in the city of Mafraq, students are…

  12. Individual language experience modulates rapid formation of cortical memory circuits for novel words (United States)

    Kimppa, Lilli; Kujala, Teija; Shtyrov, Yury


    Mastering multiple languages is an increasingly important ability in the modern world; furthermore, multilingualism may affect human learning abilities. Here, we test how the brain’s capacity to rapidly form new representations for spoken words is affected by prior individual experience in non-native language acquisition. Formation of new word memory traces is reflected in a neurophysiological response increase during a short exposure to novel lexicon. Therefore, we recorded changes in electrophysiological responses to phonologically native and non-native novel word-forms during a perceptual learning session, in which novel stimuli were repetitively presented to healthy adults in either ignore or attend conditions. We found that larger number of previously acquired languages and earlier average age of acquisition (AoA) predicted greater response increase to novel non-native word-forms. This suggests that early and extensive language experience is associated with greater neural flexibility for acquiring novel words with unfamiliar phonology. Conversely, later AoA was associated with a stronger response increase for phonologically native novel word-forms, indicating better tuning of neural linguistic circuits to native phonology. The results suggest that individual language experience has a strong effect on the neural mechanisms of word learning, and that it interacts with the phonological familiarity of the novel lexicon. PMID:27444206

  13. Visual working memory modulates low-level saccade target selection: evidence from rapidly generated saccades in the global effect paradigm. (United States)

    Hollingworth, Andrew; Matsukura, Michi; Luck, Steven J


    In three experiments, we examined the influence of visual working memory (VWM) on the metrics of saccade landing position in a global effect paradigm. Participants executed a saccade to the more eccentric object in an object pair appearing on the horizontal midline, to the left or right of central fixation. While completing the saccade task, participants maintained a color in VWM for an unrelated memory task. Either the color of the saccade target matched the memory color (target match), the color of the distractor matched the memory color (distractor match), or the colors of neither object matched the memory color (no match). In the no-match condition, saccades tended to land at the midpoint between the two objects: the global, or averaging, effect. However, when one of the two objects matched VWM, the distribution of landing position shifted toward the matching object, both for target match and for distractor match. VWM modulation of landing position was observed even for the fastest quartile of saccades, with a mean latency as low as 112 ms. Effects of VWM on such rapidly generated saccades, with latencies in the express-saccade range, indicate that VWM interacts with the initial sweep of visual sensory processing, modulating perceptual input to oculomotor systems and thereby biasing oculomotor selection. As a result, differences in memory match produce effects on landing position similar to the effects generated by differences in physical salience.

  14. A rapid, semi-quantitative assay to screen for modulators of alpha-synuclein oligomerization ex vivo

    Directory of Open Access Journals (Sweden)

    Marion eDelenclos


    Full Text Available Alpha synuclein (αsyn aggregates are associated with the pathogenesis of Parkinson’s disease and others related disorders. Although modulation of αsyn aggregation is an attractive therapeutic target, new powerful methodologies are desperately needed to facilitate in vivo screening of novel therapeutics. Here we describe an in vivo rodent model with the unique ability to rapidly track αsyn-αsyn interactions and thus oligomerization using a bioluminescent protein complementation strategy that monitors spatial and temporal αsyn oligomerization ex vivo. We find that αsyn forms oligomers in vivo as early as 1 week after stereotactic AAV injection into rat substantia nigra. Strikingly, although abundant αsyn expression is also detected in striatum at one week, no αsyn oligomers are detected at this time point. By 4 weeks, oligomerization of αsyn is detected in both striatum and substantia nigra homogenates. Moreover, in a proof-of-principle experiment, the effect of a previously described Hsp90 inhibitor known to prevent αsyn oligomer formation, demonstrates the utility of this rapid and sensitive animal model to monitor αsyn oligomerization status in the rat brain.

  15. Age, dyslexia subtype and comorbidity modulate rapid auditory processing in developmental dyslexia

    Directory of Open Access Journals (Sweden)

    Maria Luisa eLorusso


    Full Text Available The nature of Rapid Auditory Processing (RAP deficits in dyslexia remains debated, together with the specificity of the problem to certain types of stimuli and/or restricted subgroups of individuals. Following the hypothesis that the heterogeneity of the dyslexic population may have led to contrasting results, the aim of the study was to define the effect of age, dyslexia subtype and comorbidity on the discrimination and reproduction of nonverbal tone sequences.Participants were 46 children aged 8 - 14 (26 with dyslexia, subdivided according to age, presence of a previous language delay, and type of dyslexia. Experimental tasks were a Temporal Order Judgment (TOJ (manipulating tone length, ISI and sequence length, and a Pattern Discrimination Task. Dyslexic children showed general RAP deficits. Tone length and ISI influenced dyslexic and control children’s performance in a similar way, but dyslexic children were more affected by an increase from 2 to 5 sounds. As to age, older dyslexic children’s difficulty in reproducing sequences of 4 and 5 tones was similar to that of normally reading younger (but not older children. In the analysis of subgroup profiles, the crucial variable appears to be the advantage, or lack thereof, in processing long vs short sounds. Dyslexic children with a previous language delay obtained the lowest scores in RAP measures, but they performed worse with shorter stimuli, similar to control children, while dyslexic-only children showed no advantage for longer stimuli. As to dyslexia subtype, only surface dyslexics improved their performance with longer stimuli, while phonological dyslexics did not. Differential scores for short vs long tones and for long vs short ISIs predict nonword and word reading, respectively, and the former correlate with phonemic awareness.In conclusion, the relationship between nonverbal RAP, phonemic skills and reading abilities appears to be characterized by complex interactions with

  16. Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila. (United States)

    Fortier, Anne; de Chastellier, Chantal; Balor, Stéphanie; Gros, Philippe


    Legionella survives intracellularly by preventing fusion with lysosomes, due to phagosome escape from the endocytic pathway at an early stage of phagosome maturation, and by creating a replicative organelle that acquires endoplasmic reticulum (ER) characteristics through sustained interactions and fusion with the ER. Intracellular replication of Legionella pneumophila in mouse macrophages is controlled by the Lgn1 locus. Functional complementation in vivo has identified the Birc1e/Naip5 gene as being responsible for the Lgn1 effect. To understand the function and temporal site of action of Birc1e/Naip5 in susceptibility to L. pneumophila, we examined the biogenesis of Legionella-containing vacuoles (LCVs) formed in permissive A/J macrophages and in their Birc1e/Naip5 transgenic non-permissive counterpart. Birc1e/Naip5 effects on acquisition of lysosomal and ER markers were evident within 1-2 h following infection. A significantly higher proportion of LCVs formed in Birc1e/Naip5 transgenic macrophages had acquired the lysosomal markers cathepsin D and Lamp1 by 2 h post infection, whereas a significantly higher proportion of LCVs formed in permissive macrophages were positively stained for the ER markers BAP31 and calnexin, 6 h post infection. Likewise, studies by electron microscopy showed acquisition of lysosomal contents (horseradish peroxidase), within the first hour following phagocytic uptake, by LCVs formed in Birc1e/Naip5 transgenic macrophages and delivery of the ER marker glucose 6-phosphatase (G6Pase) only to the lumen of LCVs formed in A/J macrophages. Finally, a larger proportion of LCVs formed in A/J macrophages were studded with ribosomes 24 h post infection, compared with LCVs formed in Birc1e/Naip5 transgenic macrophages. These results suggest that sensing of L. pneumophila products by Birc1e/Naip5 in macrophages occurs rapidly following phagocytosis, a process that antagonizes the ability of L. pneumophila to remodel its phagosome into a specialized


    Konradsson-Geuken, Ȧ.; Gash, C. R.; Wu, H.-Q.; Alexander, K. S.; Pellicciari, R.; Schwarcz, R.; Bruno, J.P.


    Using two in vivo methods, microdialysis and rapid in situ electrochemistry, this study examined the modulation of extracellular glutamate levels by endogenously produced kynurenic acid (KYNA) in the prefrontal cortex (PFC) of awake rats. Measured by microdialysis, intraperitoneal (i.p.) administration of KYNA's bioprecursor L-kynurenine dose-dependently elevated extracellular KYNA and reduced extracellular glutamate (nadir after 50 mg/kg kynurenine: 60% decrease from baseline values). This dose-dependent decrease in glutamate levels was also seen using a glutamate-sensitive microelectrode array (MEA) (31% decrease following 50 mg/kg kynurenine). The kynurenine-induced reduction in glutamate was blocked (microdialysis) or attenuated (MEA) by co-administration of galantamine (3 mg/kg, i.p.), a drug that competes with KYNA at an allosteric potentiating site of the α7 nicotinic acetylcholine receptor. In separate experiments, extracellular glutamate levels were measured by MEA following the local perfusion (45 min) of the PFC with kynurenine (2.5 μM) or the selective KYNA biosynthesis inhibitor S-ethylsulfonylbenzoylalanine (S-ESBA; 5 mM). In agreement with previous microdialysis studies, systemic kynurenine application produced a reversible reduction in glutamate (nadir: −29%), whereas perfusion with S-ESBA increased glutamate levels reversibly (maximum: +38%). Collectively, these results demonstrate that fluctuations in the biosynthesis of KYNA in the PFC bi-directionally modulate extracellular glutamate levels, and that qualitatively very similar data are obtained by microdialysis and MEA. Since KYNA levels are elevated in the PFC of individuals with schizophrenia, and since prefrontal glutamatergic and nicotinic transmission mediate cognitive flexibility, normalization of KYNA levels in the PFC may constitute an effective treatment strategy for alleviating cognitive deficits in schizophrenia. PMID:20600676

  18. Estrogen Receptor β Activation Rapidly Modulates Male Sexual Motivation through the Transactivation of Metabotropic Glutamate Receptor 1a. (United States)

    Seredynski, Aurore L; Balthazart, Jacques; Ball, Gregory F; Cornil, Charlotte A


    In addition to the transcriptional activity of their liganded nuclear receptors, estrogens, such as estradiol (E2), modulate cell functions, and consequently physiology and behavior, within minutes through membrane-initiated events. The membrane-associated receptors (mERs) underlying the acute effects of estrogens on behavior have mostly been documented in females where active estrogens are thought to be of ovarian origin. We determined here, by acute intracerebroventricular injections of specific agonists and antagonists, the type(s) of mERs that modulate rapid effects of brain-derived estrogens on sexual motivation in male Japanese quail. Brain aromatase blockade acutely inhibited sexual motivation. Diarylpropionitrile (DPN), an estrogen receptor β (ERβ)-specific agonist, and to a lesser extent 17α-estradiol, possibly acting through ER-X, prevented this effect. In contrast, drugs targeting ERα (PPT and MPP), GPR30 (G1 and G15), and the Gq-mER (STX) did not affect sexual motivation. The mGluR1a antagonist LY367385 significantly inhibited sexual motivation but mGluR2/3 and mGluR5 antagonists were ineffective. LY367385 also blocked the behavioral restoration induced by E2 or DPN, providing functional evidence that ERβ interacts with metabotropic glutamate receptor 1a (mGluR1a) signaling to acutely regulate male sexual motivation. Together these results show that ERβ plays a key role in sexual behavior regulation and the recently uncovered cooperation between mERs and mGluRs is functional in males where it mediates the acute effects of estrogens produced centrally in response to social stimuli. The presence of an ER-mGluR interaction in birds suggests that this mechanism emerged relatively early in vertebrate history and is well conserved. Significance statement: The membrane-associated receptors underlying the acute effects of estrogens on behavior have mostly been documented in females, where active estrogens are thought to be of ovarian origin. Using acute

  19. Stereotactic body radiation therapy for abdominal targets using volumetric intensity modulated arc therapy with RapidArc: Feasibility and clinical preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Scorsetti, Marta; Bignardi, Mario; Alongi, Filippo; Mancosu, Pietro; Navarria, Piera; Castiglioni, Simona; Pentimalli, Sara; Tozzi, Angelo (IRCCS Istituto Clinico Humanitas, Rozzano (Italy)), e-mail:; Fogliata, Antonella; Cozzi, Luca (Oncology Inst. of Southern Switzerland, Bellinzona (Switzerland))


    Purpose. To report early clinical experience in stereotactic body radiation therapy (SBRT) delivered using volumetric intensity modulated arc therapy with RapidArc (RA) in patients with primary or metastatic tumours at abdominal sites. Material and methods. Thirty-seven consecutive patients were treated using RA. Of these, 16 had primary or metastatic liver tumours, nine had pancreatic cancer and 12 a nodal metastasis in the retro-peritoneum. Dose prescription varied from 45 to 75 Gy to the Clinical Target Volume in 3 to 6 fractions. The median follow-up was 12 months (6-22). Early local control and toxicity were investigated and reported. Results. Planning objectives on target volumes and organs at risk were met in most cases. Delivery time ranged from 2.8 +- 0.3 to 9.2 +- 2.4 minutes and pre-treatment plan verification resulted in a Gamma Agreement Index from 95.3 +- 3.8 to 98.3 +- 1.7%. At the time of analysis, local control (freedom from progression) at six months, was assessable in 24 of 37 patients and was achieved in 19 patients with a crude rate of 79.2%. Seven patients experienced treatment-related toxicity. Three patients experienced a mild and transient G1 enteritis and two showed a transient G1 liver damage. Two had late toxicity: one developed chronic enteritis causing G1 diarrhoea and G1 abdominal pain and one suffered at three months a G3 gastric bleeding. No patients experienced G4 acute toxicity. Conclusions. SBRT for abdominal targets delivered by means of RA resulted to be feasible with good early clinical results in terms of local control rate and acute toxicity profile. RA allowed to achieve required target coverage as well as to keep within normal tissue dose/volume constraints

  20. Rapid modulation of ultraviolet shielding in plants is influenced by solar ultraviolet radiation and linked to alterations in flavonoids. (United States)

    Barnes, Paul W; Tobler, Mark A; Keefover-Ring, Ken; Flint, Stephan D; Barkley, Anne E; Ryel, Ronald J; Lindroth, Richard L


    The accumulation of ultraviolet (UV)-absorbing compounds (flavonoids and related phenylpropanoids) and the resultant decrease in epidermal UV transmittance (TUV ) are primary protective mechanisms employed by plants against potentially damaging solar UV radiation and are critical components of the overall acclimation response of plants to changing solar UV environments. Whether plants can adjust this UV sunscreen protection in response to rapid changes in UV, as occurs on a diurnal basis, is largely unexplored. Here, we use a combination of approaches to demonstrate that plants can modulate their UV-screening properties within minutes to hours, and these changes are driven, in part, by UV radiation. For the cultivated species Abelmoschus esculentus, large (30-50%) and reversible changes in TUV occurred on a diurnal basis, and these adjustments were associated with changes in the concentrations of whole-leaf UV-absorbing compounds and several quercetin glycosides. Similar results were found for two other species (Vicia faba and Solanum lycopersicum), but no such changes were detected in Zea mays. These findings reveal a much more dynamic UV-protection mechanism than previously recognized, raise important questions concerning the costs and benefits of UV-protection strategies in plants and have practical implications for employing UV to enhance crop vigor and quality in controlled environments.

  1. A temperature control method for shortening thermal cycling time to achieve rapid polymerase chain reaction (PCR) in a disposable polymer microfluidic device (United States)

    Bu, Minqiang; Perch-Nielsen, Ivan R.; Sørensen, Karen S.; Skov, Julia; Sun, Yi; Duong Bang, Dang; Pedersen, Michael E.; Hansen, Mikkel F.; Wolff, Anders


    We present a temperature control method capable of effectively shortening the thermal cycling time of polymerase chain reaction (PCR) in a disposable polymer microfluidic device with an external heater and a temperature sensor. The method employs optimized temperature overshooting and undershooting steps to achieve a rapid ramping between the temperature steps for DNA denaturation, annealing and extension. The temperature dynamics within the microfluidic PCR chamber was characterized and the overshooting and undershooting parameters were optimized using the temperature-dependent fluorescence signal from Rhodamine B. The method was validated with the PCR amplification of mecA gene (162 bp) from methicillin-resistant Staphylococcus aureus bacterium (MRSA), where the time for 30 cycles was reduced from 50 min (without over- and undershooting) to 20 min.

  2. Novel immune-modulator identified by a rapid, functional screen of the parapoxvirus ovis (Orf virus genome

    Directory of Open Access Journals (Sweden)

    McGuire Michael J


    Full Text Available Abstract Background The success of new sequencing technologies and informatic methods for identifying genes has made establishing gene product function a critical rate limiting step in progressing the molecular sciences. We present a method to functionally mine genomes for useful activities in vivo, using an unusual property of a member of the poxvirus family to demonstrate this screening approach. Results The genome of Parapoxvirus ovis (Orf virus was sequenced, annotated, and then used to PCR-amplify its open-reading-frames. Employing a cloning-independent protocol, a viral expression-library was rapidly built and arrayed into sub-library pools. These were directly delivered into mice as expressible cassettes and assayed for an immune-modulating activity associated with parapoxvirus infection. The product of the B2L gene, a homolog of vaccinia F13L, was identified as the factor eliciting immune cell accumulation at sites of skin inoculation. Administration of purified B2 protein also elicited immune cell accumulation activity, and additionally was found to serve as an adjuvant for antigen-specific responses. Co-delivery of the B2L gene with an influenza gene-vaccine significantly improved protection in mice. Furthermore, delivery of the B2L expression construct, without antigen, non-specifically reduced tumor growth in murine models of cancer. Conclusion A streamlined, functional approach to genome-wide screening of a biological activity in vivo is presented. Its application to screening in mice for an immune activity elicited by the pathogen genome of Parapoxvirus ovis yielded a novel immunomodulator. In this inverted discovery method, it was possible to identify the adjuvant responsible for a function of interest prior to a mechanistic study of the adjuvant. The non-specific immune activity of this modulator, B2, is similar to that associated with administration of inactivated particles to a host or to a live viral infection. Administration

  3. The SouthSouthNorth Capacity Building Module on Poverty Reduction. Approaches for achieving sustainable development and poverty reduction

    Energy Technology Data Exchange (ETDEWEB)



    While sustainable development in climate change was the core approach in SSN 1, SSN 2 takes a further and direct focus on poverty reduction, as a core theme. Presented by the SSN Capacity Building Team, this Module on Poverty Reduction reflects our current approach to dealing with poverty reduction. Each SSN 2 programme is discussed separately. The SSN Matrix Tool of Indicators for Appraising the Sustainable Development of Projects, from SSN 1, is applied in SSN 2 for assessing poverty reduction by placing special emphasis on a couple of social sustainability indicators. This approach of the Mitigation Programme is followed in the Adaptation Programme. The Adaptation Programme also applies the SSN Adaptation Projects Protocol for Community Based Adaptation. This SSNAPP for CBA is a way to find the hotspots where high levels of poverty and predicted increases in climate impacts coincide. The Technology Receptivity Programme examines approaches for receiving technology in poor communities, examining not only technology hardware but also the software (processes) and orgware (institutions) required. The Capacity Building Programme uses a SWOT tool for analysing a project's strengths, weaknesses, opportunities and threats as a way to determine and ensure the sustainability of projects in terms of technology, finances and social factors. The Module gives the various tools applied by the programmes, with examples from SSN projects. It is presented by the Capacity Building Programme in this format as a movement towards an alignment of approaches within SSN and is shared for use by others who are interested in the pursuit of sustainable projects. As a work in progress this Module will be updated as work goes on.

  4. Pulse-Density Modulation with an Ensemble of Single-Electron Circuits Employing Neuronal Heterogeneity to Achieve High Temporal Resolution (United States)

    Kikombo, Andrew Kilinga; Asai, Tetsuya; Amemiya, Yoshihito

    We investigated the implications of static noises in a pulse-density modulator based on Vestibulo-ocular Reflex model. We constructed a simple neuromorphic circuit consisting of an ensemble of single-electron devices and confirmed that static noises (heterogeneity in circuit parameters) introduced into the network indeed played an important role in improving the fidelity with which neurons could encode signals whose input frequencies are higher than the intrinsic response frequencies of single neurons. Through Monte-Carlo based computer simulations, we demonstrated that the heterogeneous network could corectly encode signals with input frequencies as high as 1 GHz, twice the range for single (or a network of homogeneous) neurons.

  5. System for Rapid, Precise Modulation of Intraocular Pressure, toward Minimally-Invasive In Vivo Measurement of Intracranial Pressure. (United States)

    Stockslager, Max A; Samuels, Brian C; Allingham, R Rand; Klesmith, Zoe A; Schwaner, Stephen A; Forest, Craig R; Ethier, C Ross


    Pathologic changes in intracranial pressure (ICP) are commonly observed in a variety of medical conditions, including traumatic brain injury, stroke, brain tumors, and glaucoma. However, current ICP measurement techniques are invasive, requiring a lumbar puncture or surgical insertion of a cannula into the cerebrospinal fluid (CSF)-filled ventricles of the brain. A potential alternative approach to ICP measurement leverages the unique anatomy of the central retinal vein, which is exposed to both intraocular pressure (IOP) and ICP as it travels inside the eye and through the optic nerve; manipulating IOP while observing changes in the natural pulsations of the central retinal vein could potentially provide an accurate, indirect measure of ICP. As a step toward implementing this technique, we describe the design, fabrication, and characterization of a system that is capable of manipulating IOP in vivo with tree shrews (Tupaia belangeri) while video of the retinal vessels was recorded and the caliber of a selected vein was quantified. Modulating IOP using our system elicited a rapid change in the appearance of the retinal vein of interest: IOP was lowered from 10 to 3 mmHg, and retinal vein caliber sharply increased as IOP decreased from 7 to 5 mmHg. Another important feature of this technology is its capability to measure ocular compliance and outflow facility in vivo, as demonstrated in tree shrews. Collectively, these proof-of-concept demonstrations support the utility of this system to manipulate IOP for a variety of useful applications in ocular biomechanics, and provide a framework for further study of the mechanisms of retinal venous pulsation.

  6. System for Rapid, Precise Modulation of Intraocular Pressure, toward Minimally-Invasive In Vivo Measurement of Intracranial Pressure.

    Directory of Open Access Journals (Sweden)

    Max A Stockslager

    Full Text Available Pathologic changes in intracranial pressure (ICP are commonly observed in a variety of medical conditions, including traumatic brain injury, stroke, brain tumors, and glaucoma. However, current ICP measurement techniques are invasive, requiring a lumbar puncture or surgical insertion of a cannula into the cerebrospinal fluid (CSF-filled ventricles of the brain. A potential alternative approach to ICP measurement leverages the unique anatomy of the central retinal vein, which is exposed to both intraocular pressure (IOP and ICP as it travels inside the eye and through the optic nerve; manipulating IOP while observing changes in the natural pulsations of the central retinal vein could potentially provide an accurate, indirect measure of ICP. As a step toward implementing this technique, we describe the design, fabrication, and characterization of a system that is capable of manipulating IOP in vivo with <0.1 mmHg resolution and settling times less than 2 seconds. In vitro tests were carried out to characterize system performance. Then, as a proof of concept, we used the system to manipulate IOP in tree shrews (Tupaia belangeri while video of the retinal vessels was recorded and the caliber of a selected vein was quantified. Modulating IOP using our system elicited a rapid change in the appearance of the retinal vein of interest: IOP was lowered from 10 to 3 mmHg, and retinal vein caliber sharply increased as IOP decreased from 7 to 5 mmHg. Another important feature of this technology is its capability to measure ocular compliance and outflow facility in vivo, as demonstrated in tree shrews. Collectively, these proof-of-concept demonstrations support the utility of this system to manipulate IOP for a variety of useful applications in ocular biomechanics, and provide a framework for further study of the mechanisms of retinal venous pulsation.

  7. Benefits of achieving vigorous as well as moderate physical activity recommendations: evidence from heart rate complexity and cardiac vagal modulation. (United States)

    Soares-Miranda, Luisa; Sandercock, Gavin; Vale, Susana; Silva, Pedro; Moreira, Carla; Santos, Rute; Mota, Jorge


    The aim of this study was to examine differences in traditional heart rate variability measurements and heart rate complexity (sample entropy) in young adults grouped by objectively measured achievement of either moderate or both moderate and vigorous physical activity recommendations. Of 168 young adults tested (86 females, 82 males; age 20.5 ± 1.2 years), 119 achieved only recommendations for moderate physical activity (moderate group) and 49 achieved recommendations for both moderate and vigorous physical activity (vigorous group). Analysis of covariance controlling for sex, weekly minutes of moderate physical activity, and percentage of body fat was used to assess between-group differences in heart rate variability and heart rate complexity. Logistic regression analysis was used to determine the group characteristics that best predicted high heart rate complexity and vagal indices of heart rate variability. The majority of the autonomic measures were higher (P heart rate complexity and higher heart rate variability. Young adults engaged in regular vigorous physical activity were more than twice as likely to have high heart rate complexity than those involved in predominantly moderate exercise. These findings suggest that vigorous physical activity is more closely associated with high heart rate complexity than moderate physical activity in young adults.

  8. Bunch stabilization using rf phase modulation in the Intense Pulse Neutron Source (IPNS) Rapid Cycling Synchrotron (RCS).

    Energy Technology Data Exchange (ETDEWEB)

    Brumwell, F. R.; Dooling, J. C.; McMichael, G. E.


    Phase modulation (PM) is used to increase the current limit in the IPNS RCS. A device referred to as a scrambler introduces a small oscillating phase between the two RCS rf cavities at approximately twice the synchrotrons frequency, f{sub s}. The modulation introduced by the scrambler generates longitudinal oscillations in the bunch at 2f{sub s}. Modulations in the bunch are also observed transversely indicating a coupling between longitudinal and transverse motion. Comparing PM with amplitude modulation (AM), coupling to the beam is roughly equivalent at 2f{sub s}.

  9. Simple combination of oxidants with zero-valent-iron (ZVI) achieved very rapid and highly efficient removal of heavy metals from water. (United States)

    Guo, Xuejun; Yang, Zhe; Dong, Haiyang; Guan, Xiaohong; Ren, Qidong; Lv, Xiaofang; Jin, Xin


    This study, for the first time, demonstrated a continuously accelerated Fe(0) corrosion driven by common oxidants (i.e., NaClO, KMnO4 or H2O2) and thereby the rapid and efficient removal of heavy metals (HMs) by zero-valent iron (ZVI) under the experimental conditions of jar tests and column running. ZVI simply coupled with NaClO, KMnO4 or H2O2 (0.5 mM) resulted in almost complete As(V) removal within only 10 min with 1000 μg/L of initial As(V) at initial pH of 7.5(±0.1) and liquid solid ratio of 200:1. Simultaneous removal of 200 μg/L of initial Cd(II) and Hg(II) to 2.4-4.4 μg/L for Cd(II) and to 4.0-5.0 μg/L for Hg(II) were achieved within 30 min. No deterioration of HM removal was observed during the ten recycles of jar tests. The ZVI columns activated by 0.1 mM of oxidants had stably treated 40,200 (NaClO), 20,295 (KMnO4) and 40,200 (H2O2) bed volumes (BV) of HM-contaminated drinking water, but with no any indication of As breakthrough (removal from both the jar tests and column running implied a continuous and stable activation (overcoming of iron passivation) of Fe(0) surface by the oxidants. Via the proper increase in oxidant dosing, the ZVI/oxidant combination was applicable to treat highly As(V)-contaminated wastewater. During Fe(0) surface corrosion accelerated by oxidants, a large amount of fresh and reactive iron oxides and oxyhydroxides were continuously generated, which were responsible for the rapid and efficient removal of HMs through multiple mechanisms including adsorption and co-precipitation. A steady state of Fe(0) surface activation and HM removal enabled this simply coupled system to remove HMs with high speed, efficiency and perdurability.

  10. Based on FPGA Achieve OFDM Baseband Modulation System%基于FPGA技术实现的OFDM基带调制系统

    Institute of Scientific and Technical Information of China (English)

    殷严刚; 王小华; 何富运


    The target of OFDM is high-speed serial data stream into low-speed parallel data streams,and modulation spectrum is to transmit the orthogonal subcarriers overlap,so the spectrum utilization rate is advanced. And OFDM can be used to achieve IFFT/FFT modulation and demodulation,realized easily by FPGA technology. The design is based on FPGA technology to realize the modulator part of OFDM communication system, which includes RS coding,interleaving,constellation mapping,QAM,IFFT and inserted into the CP module. The speed of system can be improved and it has higher application value by the simulation.%OFDM基带调制的目的是将高速的串行数据流转换成并行的低速数据流,再调制到频谱是正交重叠的子载波上进行传输,以便于提高频谱利用率。 OFDM可以采用IFFT/FFT实现调制解调,在本设计中采用FPGA技术可以比较容易地实现OFDM通信系统的的调制器部分。整个系统包括RS编码、交织、QAM星座映射,IFFT和插入CP等模块,经过仿真验证:提高了系统的处理速度,具有较高的应用价值。

  11. Limits on Achievable Dimensional and Photon Efficiencies with Intensity-Modulation and Photon-Counting Due to Non-Ideal Photon-Counter Behavior (United States)

    Moision, Bruce; Erkmen, Baris I.; Farr, William; Dolinar, Samuel J.; Birnbaum, Kevin M.


    An ideal intensity-modulated photon-counting channel can achieve unbounded photon information efficiencies (PIEs). However, a number of limitations of a physical system limit the practically achievable PIE. In this paper, we discuss several of these limitations and illustrate their impact on the channel. We show that, for the Poisson channel, noise does not strictly bound PIE, although there is an effective limit, as the dimensional information efficiency goes as e[overline] e PIE beyond a threshold PIE. Since the Holevo limit is bounded in the presence of noise, this illustrates that the Poisson approximation is invalid at large PIE for any number of noise modes. We show that a finite transmitter extinction ratio bounds the achievable PIE to a maximum that is logarithmic in the extinction ratio. We show how detector jitter limits the ability to mitigate noise in the PPM signaling framework. We illustrate a method to model detector blocking when the number of detectors is large, and illustrate mitigation of blocking with spatial spreading and altering. Finally, we illustrate the design of a high photon efficiency system using state-of-the-art photo-detectors and taking all these effects into account.

  12. Comparison of Rapid Arc and Intensity-modulated Radiotherapy Plans Using Unified Dosimetry Index and the Impact of Conformity Index on Unified Dosimetry Index Evaluation. (United States)

    Krishnan, Jayapalan; Shetty, Jayarama; Rao, Suresh; Hegde, Sanath; Shambhavi, C


    The aim of this study was to evaluate the impact of conformity index in the unified dosimetry index (UDI) score for two different planning techniques namely intensity-modulated radiotherapy (IMRT) and Rapid Arc. Rapid Arc and IMRT plans of 57 patients were evaluated and compared using UDI score which incorporates four indices. To determine the impact of conformity index on the IMRT and Rapid Arc plans, UDI at conformity index one of all plan (UDIunit_CI) score was calculated by assuming conformity index is equal to one. Mean and standard deviations of all indices were calculated. Rapid Arc technique plans of different treatment sites of all patients scored lesser UDI than IMRT plans, and the conformity index of Rapid Arc plan was significantly better than IMRT plan. The average dose gradient, homogeneity, coverage, and conformity index of all sites with Rapid Arc plans were 0.212 ± 0.05, 1.123 ± 0.03, 0.959 ± 0.03, and 1.056 ± 0.09; with IMRT plans were 0.190 ± 0.05, 1.113 ± 0.04, 0.950 ± 0.04, and 1.172 ± 0.16, respectively. UDI score value with actual conformity index of Rapid Arc and IMRT plans differed significantly (P conformity index equal to one did not differ significantly (P = 0.528). In the comparison of IMRT and Rapid Arc plans using the UDI score, the impact of conformity index was significant.

  13. Comparison of rapidArc and fixed field intensity-modulated radiation therapies for advanced nasopharyngeal carcinoma%晚期鼻咽癌RapidArc与固定野调强放疗的比较研究

    Institute of Scientific and Technical Information of China (English)

    庄名赞; 张拓丹; 彭逊; 陈志坚; 林志雄; 李德锐


      目的:近年RapidArc的临床应用已引起越来越多的关注,本研究比较RapidArc与固定野调强放射治疗(IMRT)两种放疗技术在晚期鼻咽癌治疗计划中的差异.方法:随机选取10例晚期鼻咽癌患者,采用RapidArc与IMRT两种技术进行计划设计与剂量验证,比较计划的靶区剂量、危及器官与正常组织剂量、机器跳数、治疗时间与剂量验证结果.结果:两种计划的剂量分布基本一致,均能提供足够的靶区剂量.RapidArc的PTVnx最小剂量,PTVnd、PTV60、喉、腮腺的平均剂量低于IMRT,PTV60的HI值高于 IMRT,机器跳数比 IMRT 减少约58%,治疗时间减少约70%.以3%/3mm 为界,RapidArc 验证的γ指数通过率为(98.75±0.50)%,IMRT的通过率为(98.86±0.67)%.结论:两种放疗技术均能够满足临床治疗需要,剂量验证结果能够较好的符合计划计算结果.RapidArc比IMRT有着更多的优势,不仅可以减少机器跳数,缩短治疗时间,而且可以减少喉、腮腺的受照剂量.%Objective: This study compares volumetric-modulated arc therapy (RapidArc) and fixed field intensity-modulated radiation therapy (IMRT) for advanced nasopharyngeal carcinoma. Methods: Ten advanced nasopharyngeal carcinoma patients were randomly selected for this study. Two treatment plans were completed for each patient, i.e., the RapidArc and IMRT schemes. Dosimetric verification was conducted for each scheme. The doses for the planning target volumes (PTVs), organs at risk (OARs), and normal tissues were compared. The technical delivery parameters, including monitor units (MUs), time of therapy, and results of dosimetric verification, were analyzed. Results: No significant differences were found in dose distribution between the two schemes. Both techniques delivered adequate doses for the PTVs. For RapidArc planning, the minimal dose of PTVnx, mean dose of PTVnd, PTV60, larynx, and parotid were lower compared with those of IMRT schemes, whereas the

  14. Dosimetry Comparison between Volumetric Modulated Arc Therapy with RapidArc and Fixed Field Dynamic IMRT for Local-Regionally Advanced Nasopharyngeal Carcinoma

    Institute of Scientific and Technical Information of China (English)

    Bao-min Zheng; Xiao-xia Dong; Hao Wu; You-jia Duan; Shu-kui Han; Yan Sun


    Objective:A dosimetric study was performed to evaluate the performance of volumetric modulated arc radiotherapy with RapidArc on locally advanced nasopharyngeal carcinoma (NPC).Methods:The CT scan data sets of 20 patients of locally advanced NPC were selected randomly.The plans were managed using volumetric modulated arc with RapidArc and fixed nine-field coplanar dynamic intensity-modulated radiotherapy (IMRT) for these patients.The dosimetry of the planning target volumes (PTV),the organs at risk (OARs) and the healthy tissue were evaluated.The dose prescription was set to 70 Gy to the primary tumor and 60 Gy to the clinical target volumes (CTV) in 33 fractions.Each fraction applied daily,five fractions per week.The monitor unit (MU) values and the delivery time were scored to evaluate the expected treatment efficiency.Results:Both techniques had reached clinical treatment's requirement.The mean dose (Dmean),maximum dose (Dmax) and minimum dose (Dmin) in RapidArc and fixed field IMRT for PTV were 68.4±0.6 Gy,74.8±0.9 Gy and 56.8±1.1 Gy; and 67.6±0.6 Gy,73.8±0.4 Gy and 57.5±0.6 Gy (P<0.05),respectively.Homogeneity index was 78.85±1.29 in RapidArc and 80.34±0.54 (P<0.05) in IMRT.The conformity index (CI:95%) was 0.78±0.01 for both techniques (P>0.05).Compared to IMRT,RapidArc allowed a reduction of Dmean to the brain stem,mandible and optic nerves of 14.1% (P<0.05),5.6% (P<0.05) and 12.2% (P<0.05),respectively.For the healthy tissue and the whole absorbed dose,Dmean of RapidArc was reduced by 3.6% (P<0.05),and 3.7% (P<0.05),respectively.The Dmean to the parotids,the spinal cord and the lens had no statistical difference among them.The mean MU values of RapidArc and IMRT were 550 and 1,379.The mean treatment time of RapidArc and IMRT was 165 s and 447 s.Compared to IMRT,the delivery time and the MU values of RapidArc were reduced by 63% and 60%,respectively.Conclusion:For locally advanced NPC,both RapidArc and IMRT reached

  15. Rapid thermal annealing and modulation-doping effects on InAs/GaAs quantum dots photoluminescence dependence on excitation power

    Energy Technology Data Exchange (ETDEWEB)

    Chaâbani, W. [Laboratoire Matériaux-Molécules et Applications, Institut Préparatoire aux Etudes Scientifiques et Techniques, Université de Carthage, La Marsa 2070 (Tunisia); Melliti, A., E-mail: [Laboratoire Matériaux-Molécules et Applications, Institut Préparatoire aux Etudes Scientifiques et Techniques, Université de Carthage, La Marsa 2070 (Tunisia); Maaref, M.A. [Laboratoire Matériaux-Molécules et Applications, Institut Préparatoire aux Etudes Scientifiques et Techniques, Université de Carthage, La Marsa 2070 (Tunisia); Testelin, C. [Institut des NanoSciences de Paris, UPMC Univ., Paris 06, UMR 7588, F-75005 Paris (France); CNRS, UMR 7588, INSP, F-75005 Paris (France); Lemaître, A. [Laboratoire de Photonique et Nanostructures (LPN), CNRS, Route de Nozay, F-91460 Marcoussis (France)


    The optical properties of p-doped and annealed InAs/GaAs quantum dots (QDs) was investigated by photoluminescence (PL) as a function of temperature and excitation power density (P{sub exc}). At low-T, PL spectra of rapid thermal annealing (RTA) and p-modulation doped QDs show an energy blueshift and redshift, respectively. A superlinear dependence of integrated PL intensity on P{sub exc} at high-T was found only for undoped QD. The superlinearity was suppressed by modulation-doping and RTA effects. A linear dependence of I{sub PL} at all temperatures and a decrease of the carrier-carrier Coulomb interaction at high-T was found after RTA.

  16. [Serotonin uptake inhibitors provide rapid relief from premenstrual dysphoria. New findings shed light on how serotonin modulates sex hormone-related behavior]. (United States)

    Eriksson, E; Andersch, B; Ho, H P; Landén, M; Sundblad, C


    Premenstrual dysphoria (PMD) is a severe form of premenstrual syndrome, afflicting 5-10% of all women. The cardinal symptom--surfacing between ovulation and menstruation, and disappearing within a few days after the onset of the bleeding--is irritability. Serotonin reuptake inhibitors (SRIs), but not non-serotonergic antidepressants, reduce the symptoms of PMD very effectively. Since the, onset of action of SRIs is rapid when used for PMD, medication may be restricted to the luteal phase. The finding that SRIs are effective for PMD lends support for the hypothesis that a major role for brain serotonin is to modulate sex steroid-driven behavior.

  17. Achievement of Preassigned Spectra in the Synthesis of Band-Pass Constant-Envelope Signals by Rapidly Hopping through Discrete Frequencies

    CERN Document Server

    Callegari, Sergio


    Spread-spectrum signals are increasingly adopted in fields including communications, testing of electronic systems, Electro-Magnetic Compatibility (EMC) enhancement, ultrasonic non-destructive testing. This paper considers the synthesis of constant-envelope band-pass wave-forms with preassigned spectra via an FM technique using only a limited number of frequencies. In particular, an optimization-based approach for the selection of appropriate modulation parameters and statistical features of the modulating waveform is proposed. By example, it is shown that the design problem generally admits multiple local optima, but can still be managed with relative ease since the local optima can typically be scanned by changing the initial setting of a single parameter.

  18. Rapid suppression of Onchocerca volvulus transmission in two communities of the Southern Chiapas focus, Mexico, achieved by quarterly treatments with Mectizan. (United States)

    Rodríguez-Pérez, Mario A; Lutzow-Steiner, Miguel A; Segura-Cabrera, Aldo; Lizarazo-Ortega, Cristian; Domínguez-Vázquez, Alfredo; Sauerbrey, Mauricio; Richards, Frank; Unnasch, Thomas R; Hassan, Hassan K; Hernández-Hernández, Raymundo


    The impact of quarterly Mectizan (ivermectin) treatments on transmission, microfiladermia, and ocular lesions was evaluated in two formerly hyperendemic communities (Las Golondrinas and Las Nubes II) located in the main endemic focus for onchocerciasis in Southern Chiapas, Mexico. The data suggest that Onchocerca volvulus transmission has been suppressed after elimination of microfiladermia in these two communities. Increasing the frequency of Mectizan treatment to four times per year appears to have resulted in the rapid suppression of transmission in communities with residual transmission.

  19. Building a Rapid Learning Health Care System for Oncology: Why CancerLinQ Collects Identifiable Health Information to Achieve Its Vision. (United States)

    Shah, Alaap; Stewart, Andrew K; Kolacevski, Andrej; Michels, Dina; Miller, Robert


    The ever-increasing volume of scientific discoveries, clinical knowledge, novel diagnostic tools, and treatment options juxtaposed with rising costs in health care challenge physicians to identify, prioritize, and use new information rapidly to deliver efficient and high-quality care to a growing and aging patient population. CancerLinQ, a rapid learning health care system in oncology, is an initiative of the American Society of Clinical Oncology and its Institute for Quality that addresses these challenges by collecting information from the electronic health records of large numbers of patients with cancer. CancerLinQ is first and foremost a quality measurement and reporting system through which oncologists can harness the depth and power of their patients' clinical records and other data to assess, monitor, and improve the care they deliver. However, in light of privacy and security concerns with regard to collection, use, and disclosure of patient information, this article addresses the need to collect protected health information as defined under the Health Insurance Portability and Accountability Act of 1996 to drive rapid learning through CancerLinQ.

  20. 1'-Acetoxychavicol acetate-induced cytotoxicity is accompanied by a rapid and drastic modulation of glutathione metabolism. (United States)

    Higashida, Mami; Xu, Shenghui; Kojima-Yuasa, Akiko; Kennedy, David Opare; Murakami, Akira; Ohigashi, Hajime; Matsui-Yuasa, Isao


    The effect of 1'-acetoxychavicol acetate (ACA), an anticarcinogenic compound naturally obtained from rhizomes and seeds of South East Asia plants, on the intracellular concentration of glutathione and the activities of enzymes related to glutathione metabolism was studied in Ehrlich ascites tumor cells. We showed in a previous study that ACA induced apoptosis in tumor cells and the cell death was reversed by the addition of N-acetlycysteine or glutathione ethylester. Here we found that ACA caused a rapid decrease in glutathione level in less than 10 min after ACA exposure. At the time, glutathione reductase activity was significantly inhibited and gamma-glutamyl cysteine increased by ACA exposure. These results show that ACA caused the decrease in the intracellular GSH levels in Ehrlich ascites tumor cells, suggesting that ACA-induced decrease of the cellular GSH levels can lead to growth arrest of cancer and enhancement of the efficacy other anticancer drugs.

  1. Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response or intolerance to imatinib (United States)

    Shah, Neil P.; Kim, Dong-Wook; Kantarjian, Hagop; Rousselot, Philippe; Llacer, Pedro Enrique Dorlhiac; Enrico, Alicia; Vela-Ojeda, Jorge; Silver, Richard T.; Khoury, Hanna Jean; Müller, Martin C.; Lambert, Alexandre; Matloub, Yousif; Hochhaus, Andreas


    Background Dasatinib 100 mg once daily achieves intermittent BCR-ABL kinase inhibition and is approved for chronic-phase chronic myeloid leukemia patients resistant or intolerant to imatinib. To better assess durability of response to and tolerability of dasatinib, data from a 2-year minimum follow-up for a dose-optimization study in chronic-phase chronic myeloid leukemia are reported here. Design and Methods In a phase 3 study, 670 chronic-phase chronic myeloid leukemia patients with resistance, intolerance, or suboptimal response to imatinib were randomized to dasatinib 100 mg once-daily, 50 mg twice-daily, 140 mg once-daily, or 70 mg twice-daily. Results Data from a 2-year minimum follow-up demonstrate that dasatinib 100 mg once daily achieves major cytogenetic response and complete cytogenetic response rates comparable to those in the other treatment arms, and reduces the frequency of key side effects. Comparable 2-year progression-free survival and overall survival rates were observed (80% and 91%, respectively, for 100 mg once daily, and 75%–76% and 88%–94%, respectively, in other arms). Complete cytogenetic responses were achieved rapidly, typically by 6 months. In patients treated with dasatinib 100 mg once daily for 6 months without complete cytogenetic response, the likelihood of achieving such a response by 2 years was 50% for patients who had achieved a partial cytogenetic response, and only 8% or less for patients with minor, minimal, or no cytogenetic response. Less than 3% of patients suffered disease transformation to accelerated or blast phase. Conclusions Intermittent kinase inhibition can achieve rapid and durable responses, indistinguishable from those achieved with more continuous inhibition. PMID:20139391

  2. Achieving high-resolution soft-tissue imaging with cone-beam CT: a two-pronged approach for modulation of x-ray fluence and detector gain (United States)

    Graham, S. A.; Siewerdsen, J. H.; Moseley, D. J.; Keller, H.; Shkumat, N. A.; Jaffray, D. A.


    Cone-beam computed tomography (CBCT) presents a highly promising and challenging advanced application of flat-panel detectors (FPDs). The great advantage of this adaptable technology is in the potential for sub-mm 3D spatial resolution in combination with soft-tissue detectability. While the former is achieved naturally by CBCT systems incorporating modern FPD designs (e.g., 200 - 400 um pixel pitch), the latter presents a significant challenge due to limitations in FPD dynamic range, large field of view, and elevated levels of x-ray scatter in typical CBCT configurations. We are investigating a two-pronged strategy to maximizing soft-tissue detectability in CBCT: 1) front-end solutions, including novel beam modulation designs (viz., spatially varying compensators) that alleviate detector dynamic range requirements, reduce x-ray scatter, and better distribute imaging dose in a manner suited to soft-tissue visualization throughout the field of view; and 2) back-end solutions, including implementation of an advanced FPD design (Varian PaxScan 4030CB) that features dual-gain and dynamic gain switching that effectively extends detector dynamic range to 18 bits. These strategies are explored quantitatively on CBCT imaging platforms developed in our laboratory, including a dedicated CBCT bench and a mobile isocentric C-arm (Siemens PowerMobil). Pre-clinical evaluation of improved soft-tissue visibility was carried out in phantom and patient imaging with the C-arm device. Incorporation of these strategies begin to reveal the full potential of CBCT for soft-tissue visualization, an essential step in realizing broad utility of this adaptable technology for diagnostic and image-guided procedures.

  3. Sustained disease-free survival achieved with withdrawal of immunosuppression after rapid relapse of myelodysplastic syndrome following myeloablative allogeneic hematopoietic transplantation: a case report

    Directory of Open Access Journals (Sweden)

    Hamilton Betty K


    Full Text Available Abstract Introduction Relapse after allogeneic hematopoietic stem cell transplantation in patients with myelodysplasia is a challenging problem with limited treatment options. Attempts to induce a graft-versus-leukemia effect have been used with limited success. In patients with myelodysplasia, sustained complete remissions have generally been limited to patients with long-term remission after transplant and those with low numbers of marrow blasts. Case presentation We report the case of a 41-year-old Caucasian woman with relapsed myelodysplastic syndrome and a high blast percentage six months after undergoing an allogeneic transplant who achieved a sustained complete remission after withdrawal of immunosuppression alone. Conclusion This case highlights the importance of a reasonable period of observation after withdrawing immunosuppression to induce graft-versus-leukemia, and the potential effectiveness of that approach.

  4. Rapid Arc, helical tomotherapy, sliding window intensity modulated radiotherapy and three dimensional conformal radiation for localized prostate cancer: A dosimetric comparison

    Directory of Open Access Journals (Sweden)

    Rajesh A Kinhikar


    Full Text Available Objective: The objective of this study was to investigate the potential role of RapidArc (RA compared with helical tomotherapy (HT, sliding window intensity modulated radiotherapy (SW IMRT and three-dimensional conformal radiation therapy (3D CRT for localized prostate cancer. Materials and Methods: Prescription doses ranged from 60 Gy to planning target volume (PTV and 66.25 Gy for clinical target volume prostate (CTV-P over 25-30 fractions. PTV and CTV-P coverage were evaluated by conformity index (CI and homogeneity index (HI. Organ sparing comparison was done with mean doses to rectum and bladder. Results: CI 95 were 1.0 ± 0.01 (RA, 0.99 ± 0.01 (HT, 0.97 ± 0.02 (IMRT, 0.98 ± 0.02 (3D CRT for PTV and 1.0 ± 0.00 (RA, HT, SW IMRT and 3D CRT for CTV-P. HI was 0.11 ± 0.03 (RA, 0.16 ± 0.08 (HT, 0.12 ± 0.03 (IMRT, 0.06 ± 0.01 (3D CRT for PTV and 0.03 ± 0.00 (RA, 0.05 ± 0.01 (HT, 0.03 ± 0.01 (SW IMRT and 3D CRT for CTV-P. Mean dose to bladder were 23.68 ± 13.23 Gy (RA, 24.55 ± 12.51 Gy (HT, 19.82 ± 11.61 Gy (IMRT and 23.56 ± 12.81 Gy (3D CRT, whereas mean dose to rectum was 36.85 ± 12.92 Gy (RA, 33.18 ± 11.12 Gy (HT, IMRT and 38.67 ± 12.84 Gy (3D CRT. Conclusion: All studied intensity-modulated techniques yield treatment plans of significantly improved quality when compared with 3D CRT, with HT providing best organs at risk sparing and RA being the most efficient treatment option, reducing treatment time to 1.45-3.7 min and monitor unit to <400 for a 2 Gy fraction.

  5. Moderate hypofractionation and simultaneous integrated boost with volumetric modulated arc therapy (RapidArc) for prostate cancer. Report of feasibility and acute toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Alongi, F.; Navarria, P.; Tozzi, A.; Mancosu, P.; Lobefalo, F.; Reggiori, G.; Scorsetti, M. [Istituto Clinico Humanitas, Rozzano, Milan (Italy). Dept. of Radiotherapy; Fogliata, A.; Clivio, A.; Cozzi, L. [Oncology Institute of Southern Switzerland, Bellinzona (Switzerland). Medical Physics Unit


    Purpose: In the present study, the acute toxicity profiles for prostate patients treated with simultaneous integrated boost (SIB) with volumetric modulated arcs in a hypofractionated regime are reported. Patients and methods: A total of 70 patients treated with RapidArc between May 2010 and September 2011 were retrospectively evaluated. Patients were stratified into low (36%), intermediate (49%), and high-risk (16%) groups. Target volumes (expanded to define the planning volumes (PTV)) were clinical target volume (CTV) 1: prostate; CTV2: CTV1 + seminal vesicles; CTV3: CTV2 + pelvic nodes. Low-risk patients received 71.4 Gy to PTV1; intermediate-risk 74.2 Gy to PTV1 and 61.6 or 65.5 Gy to PTV2; high-risk 74.2 Gy to PTV1, 61.6 or 65.5 Gy to PTV2, and 51.8 Gy to PTV3. All treatments were in 28 fractions. The median follow-up was 11 months (range 3.5-23 months). The acute rectal, gastrointestinal (GI) and genitourinary (GU) toxicities were scored according to EORTC/RTOG scales. Results: Acute toxicities were recorded for the GU [G0 = 31/70 (44%), G1 = 22/70 (31%); G2 = 16/70 (23%); G3 = 1/70 (1%)], the rectum [G0 = 46/70 (66%); G1 = 12/70 (17%); G2 = 12/70 (17%); no G3], and the GI [G0 = 54/69 (77%); G1 = 11/69 (16%); G2 = 4/69 (6%); no G3]. Median time to rectal, GU, and GI toxicities were 27, 30, and 33 days, respectively. Only the GI toxicity correlated with stage and pelvic irradiation. Univariate analysis presented significant correlations between GI toxicity and intestinal irradiation (V{sub 50} {sub Gy} and V{sub 60} {sub Gy}). In the multivariate analysis, the only significant dosimetric variable was V{sub 50} {sub Gy} for the intestinal cavity. Conclusion: Moderate hypofractionation with SIB and RapidArc was shown to be safe, with acceptable acute toxicity. Longer follow-up is needed to assess late toxicity and clinical outcome. (orig.)

  6. Modulation Methods for Neutral-Point-Clamped Wind Power Converter Achieving Loss and Thermal Redistribution Under Low-Voltage Ride-Through

    DEFF Research Database (Denmark)

    Ma, Ke; Blaabjerg, Frede


    The three-level neutral-point (NP)-clamped (3L-NPC) converter is a promising multilevel topology in the application of megawatt wind power generation systems. However, the growing requirements by grid codes may impose high stress and even give reliability problem to this converter topology....... This paper investigates the loss and thermal performances of a 10-MW 3L-NPC wind power inverter undergoing low-voltage ride-through (LVRT) operation. A series of new space vector modulation methods is then proposed to relocate the thermal loading among the power switching devices. It is concluded that......, with the proposed modulation methods, the thermal distribution in the 3L-NPC wind power inverter undergoing LVRT becomes more equal, and the junction temperature of the most stressed devices can be also relieved. Also, the control ability of the dc-bus NP potential, which is one of the crucial considerations...

  7. Dosimetric study of RapidArc plans and conventional intensity modulated radiotherapy for prostate cancer involving seminal vesicles and pelvis lymph nodes

    Directory of Open Access Journals (Sweden)

    Birendra Rout


    Full Text Available Purpose: The main purpose of this study is to (1 identify the continual diversity between conventional fixed field intensity modulation radiotherapy (IMRT and RapidArc (RA for high-risk prostate cancer; and (2 determine potential benefits and drawbacks of using for this type of treatment.Methods: A cohort of 20 prostate cases including prostate, seminal vesicles and pelvic lymph nodes was selected for this study. The primary planning target volume (PTVP and boost planning target volume (PTVB were contoured. The total prescription dose was 75.6 Gy (45 Gy to PTVP and an additional 21.6 Gy to PTVB. Two plans were generated for each PTV: multiple 7-fields for IMRT and two arcs for RA.Results: A Sigma index (IMRT: 2.75 ± 0.581; RA: 2.8 ± 0.738 for PTVP and (IMRT: 2.0 ± 0.484; RA: 2.1 ± 0.464 for PTVB indicated similar dose homogeneity inside the PTV. Conformity index (IMRT: 0.96 ± 0.047; RA: 0.95 ± 0.059 for PTVP and (IMRT: 0.97 ± 0.015; RA: 0.96 ± 0.014 for PTVB was comparable for both the techniques. IMRT offered lower mean dose to organ at risks (OARs compared to RA plans. Normal tissue integral dose in IMRT plan resulted 0.87% lower than RA plans. All the plans displayed significant increase (2.50 times for PTVP and 1.72 for PTBB in the average number of necessary monitor units (MUs with IMRT beam. Treatment delivery time of RA was 2 ‒ 6 minutes shorter than IMRT treatment.Conclusion: For PTV including pelvic lymph nodes, seminal vesicles and prostate, IMRT offered a greater degree of OARs sparing. For PTV including seminal vesicles and prostate, RA with two arcs provided comparable plan with IMRT. RA also improved the treatment efficiency due to smaller number of MUs required.

  8. Unilateral and bilateral neck SIB for head and neck cancer patients. Intensity-modulated proton therapy, tomotherapy, and RapidArc

    Energy Technology Data Exchange (ETDEWEB)

    Stromberger, Carmen; Budach, Volker; Ghadjar, Pirus; Wlodarczyk, Waldemar; Marnitz, Simone [Charite - Universitaetsmedizin Berlin, Department of Radiation Oncology and Radiotherapy, Berlin (Germany); Cozzi, Luca; Fogliata, Antonella [Humanitas Cancer Center Milan, Radiotherapy and Radiosurgery Department, Milan (Italy); Jamil, Basil [Klinikum Frankfurt Oder, Praxis fuer Strahlentherapie, Frankfurt Oder (Germany); Raguse, Jan D. [Clinic for Oral and Maxillofacial Surgery, Berlin (Germany); Boettcher, Arne [Charite - Universitaetsmedizin Berlin, Department of Otorhinolaryngology, Berlin (Germany)


    To compare simultaneous integrated boost plans for intensity-modulated proton therapy (IMPT), helical tomotherapy (HT), and RapidArc therapy (RA) for patients with head and neck cancer. A total of 20 patients with squamous cell carcinoma of the head and neck received definitive chemoradiation with bilateral (n = 14) or unilateral (n = 6) neck irradiation and were planned using IMPT, HT, and RA with 54.4, 60.8, and 70.4 GyE/Gy in 32 fractions. Dose distributions, coverage, conformity, homogeneity to planning target volumes (PTV)s and sparing of organs at risk and normal tissue were compared. All unilateral and bilateral plans showed excellent PTV coverage and acceptable dose conformity. For unilateral treatment, IMPT delivered substantially lower mean doses to contralateral salivary glands (< 0.001-1.1 Gy) than both rotational techniques did (parotid gland: 6-10 Gy; submandibular gland: 15-20 Gy). Regarding the sparing of classical organs at risk for bilateral treatment, IMPT and HT were similarly excellent and RA was satisfactory. For unilateral neck irradiation, IMPT may minimize the dry mouth risk in this subgroup but showed no advantage over HT for bilateral neck treatment regarding classical organ-at-risk sparing. All methods satisfied modern standards regarding toxicity and excellent target coverage for unilateral and bilateral treatment of head and neck cancer at the planning level. (orig.) [German] Planvergleich von intensitaetsmodulierter Protonentherapie (IMPT), Tomotherapie (HT) und RapidArc-Therapie (RA) fuer Patienten mit Plattenepithelkarzinomen der Kopf-Hals-Region unter Anwendung des simultan integrierten Boost-Konzepts (SIB). Fuer 20 Patienten mit Plattenepithelkarzinomen der Kopf-Hals-Region und bilateraler (n = 14) oder unilateraler (n = 6) zervikaler primaerer Radiochemotherapie erfolgte eine IMPT-, HT- und RA-Planung mit 54,4, 60,8 und 70,4 GyE/Gy in 32 Fraktionen. Die Dosisverteilung, Abdeckung, Konformitaet und Homogenitaet der PTVs sowie die

  9. Dosimetric study of volumetric arc modulation with RapidArc and intensity-modulated radiotherapy in patients with cervical cancer and comparison with 3-dimensional conformal technique for definitive radiotherapy in patients with cervical cancer

    Energy Technology Data Exchange (ETDEWEB)

    Guy, Jean-Baptiste [Department of Radiation Oncology, Institut de Cancérologie de la Loire Lucien Neuwirth, Saint-Priest en Jarez (France); Falk, Alexander T. [Department of Radiation Oncology, Centre Antoine Lacassagne, Nice (France); Auberdiac, Pierre [Department of Radiation Oncology, Clinique Claude Bernard, Albi (France); Cartier, Lysian; Vallard, Alexis [Department of Radiation Oncology, Institut de Cancérologie de la Loire Lucien Neuwirth, Saint-Priest en Jarez (France); Ollier, Edouard [Department of Pharmacology-Toxicology, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Priest en Jarez (France); Trone, Jane-Chloé; Khodri, Moustapha [Department of Radiation Oncology, Institut de Cancérologie de la Loire Lucien Neuwirth, Saint-Priest en Jarez (France); Chargari, Cyrus [Department of Radiation Oncology, Hôpital d’instruction de Armées du Val-de-Grâce, Paris (France); Magné, Nicolas, E-mail: [Department of Radiation Oncology, Institut de Cancérologie de la Loire Lucien Neuwirth, Saint-Priest en Jarez (France)


    Introduction: For patients with cervical cancer, intensity-modulated radiation therapy (IMRT) improves target coverage and allows dose escalation while reducing the radiation dose to organs at risk (OARs). In this study, we compared dosimetric parameters among 3-dimensional conformal radiotherapy (3D-CRT), “step-and-shoot” IMRT, and volumetric intensity-modulated arc radiotherapy (VMAT) in a series of patients with cervical cancer receiving definitive radiotherapy. Computed tomography (CT) scans of 10 patients with histologically proven cervical cancer treated with definitive radiation therapy (RT) from December 2008 to March 2010 at our department were selected for this study. The gross tumor volume (GTV) and clinical target volume (CTV) were delineated following the guidelines of the Gyn IMRT consortium that included cervix, uterus, parametrial tissues, and the pelvic nodes including presacral. The median age was 57 years (range: 30 to 85 years). All 10 patients had squamous cell carcinoma with Federation of Gynecology and Obstetrics (FIGO) stage IB-IIIB. All patients were treated by VMAT. OAR doses were significantly reduced for plans with intensity-modulated technique compared with 3D-CRT except for the dose to the vagina. Between the 2 intensity-modulated techniques, significant difference was observed for the mean dose to the small intestine, to the benefit of VMAT (p < 0.001). There was no improvement in terms of OARs sparing for VMAT although there was a tendency for a slightly decreased average dose to the rectum: − 0.65 Gy but not significant (p = 0.07). The intensity modulation techniques have many advantages in terms of quality indexes, and particularly OAR sparing, compared with 3D-CRT. Following the ongoing technologic developments in modern radiotherapy, it is essential to evaluate the intensity-modulated techniques on prospective studies of a larger scale.

  10. Achieving Standardization

    DEFF Research Database (Denmark)

    Henningsson, Stefan


    competitive, national customs and regional economic organizations are seeking to establish a standardized solution for digital reporting of customs data. However, standardization has proven hard to achieve in the socio-technical e-Customs solution. In this chapter, the authors identify and describe what has...

  11. Achieving Standardization

    DEFF Research Database (Denmark)

    Henningsson, Stefan


    competitive, national customs and regional economic organizations are seeking to establish a standardized solution for digital reporting of customs data. However, standardization has proven hard to achieve in the socio-technical e-Customs solution. In this chapter, the authors identify and describe what has...

  12. Addressing solar modulation and long-term uncertainties in scaling secondary cosmic rays for in situ cosmogenic nuclide applications [rapid communication (United States)

    Lifton, Nathaniel A.; Bieber, John W.; Clem, John M.; Duldig, Marc L.; Evenson, Paul; Humble, John E.; Pyle, Roger


    Solar modulation affects the secondary cosmic rays responsible for in situ cosmogenic nuclide (CN) production the most at the high geomagnetic latitudes to which CN production rates are traditionally referenced. While this has long been recognized (e.g., D. Lal, B. Peters, Cosmic ray produced radioactivity on the Earth, in: K. Sitte (Ed.), Handbuch Der Physik XLVI/2, Springer-Verlag, Berlin, 1967, pp. 551-612 and D. Lal, Theoretically expected variations in the terrestrial cosmic ray production rates of isotopes, in: G.C. Castagnoli (Ed.), Proceedings of the Enrico Fermi International School of Physics 95, Italian Physical Society, Varenna 1988, pp. 216-233), these variations can lead to potentially significant scaling model uncertainties that have not been addressed in detail. These uncertainties include the long-term (millennial-scale) average solar modulation level to which secondary cosmic rays should be referenced, and short-term fluctuations in cosmic ray intensity measurements used to derive published secondary cosmic ray scaling models. We have developed new scaling models for spallogenic nucleons, slow-muon capture and fast-muon interactions that specifically address these uncertainties. Our spallogenic nucleon scaling model, which includes data from portions of 5 solar cycles, explicitly incorporates a measure of solar modulation ( S), and our fast- and slow-muon scaling models (based on more limited data) account for solar modulation effects through increased uncertainties. These models improve on previously published models by better sampling the observed variability in measured cosmic ray intensities as a function of geomagnetic latitude, altitude, and solar activity. Furthermore, placing the spallogenic nucleon data in a consistent time-space framework allows for a more realistic assessment of uncertainties in our model than in earlier ones. We demonstrate here that our models reasonably account for the effects of solar modulation on measured

  13. Clinical application of RapidArc volumetric modulated arc therapy as a component in whole brain radiation therapy for poor prognostic, four or more multiple brain metastases

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Heon; Lee, Kyu Chan; Choi, Jin Ho; Kim, Hye Young; Lee, Seok Ho; Sung, Ki Hoon; Kim, Yun Mi [Gachon University Gil Hospital, Incheon (Korea, Republic of)


    To determine feasibility of RapidArc in sequential or simultaneous integrated tumor boost in whole brain radiation therapy (WBRT) for poor prognostic patients with four or more brain metastases. Nine patients with multiple ({>=}4) brain metastases were analyzed. Three patients were classified as class II in recursive partitioning analysis and 6 were class III. The class III patients presented with hemiparesis, cognitive deficit, or apraxia. The ratio of tumor to whole brain volume was 0.8-7.9%. Six patients received 2-dimensional bilateral WBRT, (30 Gy/10- 12 fractions), followed by sequential RapidArc tumor boost (15-30 Gy/4-10 fractions). Three patients received RapidArc WBRT with simultaneous integrated boost to tumors (48-50 Gy) in 10-20 fractions. The median biologically effective dose to metastatic tumors was 68.1 Gy10 and 67.2 Gy10 and the median brain volume irradiated more than 100 Gy3 were 1.9% (24 cm3) and 0.8% (13 cm3) for each group. With less than 3 minutes of treatment time, RapidArc was easily applied to the patients with poor performance status. The follow-up period was 0.3-16.5 months. Tumor responses among the 6 patients who underwent follow-up magnetic resonance imaging were partial and stable in 3 and 3, respectively. Overall survival at 6 and 12 months were 66.7% and 41.7%, respectively. The local progression-free survival at 6 and 12 months were 100% and 62.5%, respectively. RapidArc as a component in whole brain radiation therapy for poor prognostic, multiple brain metastases is an effective and safe modality with easy application.

  14. Discovery of periodic modulations in the optical spectra of galaxies, possibly due to ultra-rapid light bursts from their massive central black hole

    CERN Document Server

    Borra, Ermanno F


    A Fourier transform analysis of 2.5 million spectra in the SDSS survey was carried out to detect periodic modulations contained in their intensity versus frequency spectrum. A statistically significant signal was found for 223 galaxies while the spectra of 0.9 million galaxies were observed. A plot of the periods as a function of redshift clearly shows that the effect is real without any doubt, because they are quantized at two base periods that increase with redshift in two very tight parallel linear relations. I suggest that it could be caused by light bursts separated by times of the order of 10-13 seconds because it was the original reason for searching for the spectral periodicity but other causes may be possible. As another possible cause, I investigate the hypothesis that the modulation is generated by the Fourier transform of spectral lines, concluding that it is not valid. Although the light bursts suggestion implies absurdly high temperatures, it is supported by the fact that the Crab pulsar also ha...

  15. Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program. (United States)

    Negorev, Dmitri G; Vladimirova, Olga V; Kossenkov, Andrew V; Nikonova, Elena V; Demarest, Renee M; Capobianco, Anthony J; Showe, Michael K; Rauscher, Frank J; Showe, Louise C; Maul, Gerd G


    Identifying the functions of proteins, which associate with specific subnuclear structures, is critical to understanding eukaryotic nuclear dynamics. Sp100 is a prototypical protein of ND10/PML nuclear bodies, which colocalizes with Daxx and the proto-oncogenic PML. Sp100 isoforms contain SAND, PHD, Bromo, and HMG domains and are highly sumoylated, all characteristics suggestive of a role in chromatin-mediated gene regulation. A role for Sp100 in oncogenesis has not been defined previously. Using selective Sp100 isoform-knockdown approaches, we show that normal human diploid fibroblasts with reduced Sp100 levels rapidly senesce. Subsequently, small rapidly dividing Sp100 minus cells emerge from the senescing fibroblasts and are found to be highly tumorigenic in nude mice. The derivation of these tumorigenic cells from the parental fibroblasts is confirmed by microsatellite analysis. The small rapidly dividing Sp100 minus cells now also lack ND10/PML bodies, and exhibit genomic instability and p53 cytoplasmic sequestration. They have also activated MYC, RAS, and TERT pathways and express mesenchymal to epithelial transdifferentiation (MET) markers. Reintroduction of expression of only the Sp100A isoform is sufficient to maintain senescence and to inhibit emergence of the highly tumorigenic cells. Global transcriptome studies, quantitative PCR, and protein studies, as well as immunolocalization studies during the course of the transformation, reveal that a transient expression of stem cell markers precedes the malignant transformation. These results identify a role for Sp100 as a tumor suppressor in addition to its role in maintaining ND10/PML bodies and in the epigenetic regulation of gene expression.

  16. Rapid acquisition and modulation of colistin-resistance by an extensively drug-resistant Acinetobacter baumannii: case report and review of current literature

    Directory of Open Access Journals (Sweden)

    Jari Intra


    Full Text Available Acinetobacter baumannii has emerged as a major cause of healthcare-associated infections. It commonly expresses clinical resistance to multiple antimicrobial agents, and hence, it is considered the paradigm of an extensively drug-resistant (XDR bacterium. XDR A. baumannii is a rapidly emerging pathogen, especially in the intensive care unit (ICU, causing nosocomial infections including sepsis, ventilatorassociated pneumonia, meningitis, peritonitis, urinary tract infection, and central venous catheter-related infection. In the present report, we described an in vivo evolution of A. baumannii strain from a colistinsusceptibility to a colistin-resistance state. A 65-year-old male, who suffered a duodenal ulcer, two days after hospitalization and during the stay in ICU, contracted a pneumonia and peritoneal infection by a carbapenem-resistant A. baumannii strain. After a combination treatment with colistin, vancomycin plus imipenem, and within seven days, the pathogen rapidly evolved in seven days to a pandrug-resistant phenotype. As the antimicrobial treatment was stopped, the A. baumannii isolate changed another time its profile to colistin, becoming newly susceptible, showing a very high level of adaptability to external conditions. We also have reviewed here the current literature on this worryingly public health threat.

  17. Gigahertz optical modulation. (United States)

    Riesz, R P; Biazzo, M R


    Light pulses from a mode-locked He-Ne laser have been modulated by a LiTaO(3) electrooptic crystal mounted on a thin film substrate. The crystal was driven by pulses from a GaAs Gunn effect diode. Amplitude modulation of 20% has been achieved at 2 GHz for a single pass through the modulator.

  18. RapidArc, intensity modulated photon and proton techniques for recurrent prostate cancer in previously irradiated patients: a treatment planning comparison study

    Directory of Open Access Journals (Sweden)

    Ratib Osman


    Full Text Available Abstract Background A study was performed comparing volumetric modulated arcs (RA and intensity modulation (with photons, IMRT, or protons, IMPT radiation therapy (RT for patients with recurrent prostate cancer after RT. Methods Plans for RA, IMRT and IMPT were optimized for 7 patients. Prescribed dose was 56 Gy in 14 fractions. The recurrent gross tumor volume (GTV was defined on 18F-fluorocholine PET/CT scans. Plans aimed to cover at least 95% of the planning target volume with a dose > 50.4 Gy. A maximum dose (DMax of 61.6 Gy was allowed to 5% of the GTV. For the urethra, DMax was constrained to 37 Gy. Rectal DMedian was 90 parameters. Results Tumor coverage (GTV and PTV was improved with RA (V95% 92.6 ± 7.9 and 83.7 ± 3.3%, when compared to IMRT (V95% 88.6 ± 10.8 and 77.2 ± 2.2%. The corresponding values for IMPT were intermediate for the GTV (V95% 88.9 ± 10.5% and better for the PTV (V95%85.6 ± 5.0%. The percentages of rectal and urethral volumes receiving intermediate doses (35 Gy were significantly decreased with RA (5.1 ± 3.0 and 38.0 ± 25.3% and IMPT (3.9 ± 2.7 and 25.1 ± 21.1%, when compared to IMRT (9.8 ± 5.3 and 60.7 ± 41.7%. CI90 was 1.3 ± 0.1 for photons and 1.6 ± 0.2 for protons. Integral Dose was 1.1 ± 0.5 Gy*cm3 *105 for IMPT and about a factor three higher for all photon's techniques. Conclusion RA and IMPT showed improvements in conformal avoidance relative to fixed beam IMRT for 7 patients with recurrent prostate cancer. IMPT showed further sparing of organs at risk.

  19. Rapid burst of H2O2 by plant growth regulators increases intracellular Ca2+ amounts and modulates CD4+ T cell activation. (United States)

    Ahmed, Asma; Mukherjee, Sambuddho; Deobagkar, Mukta; Naik, Tanushree; Nandi, Dipankar


    The identification of small molecules that affect T cell activation is an important area of research. Three molecules that regulate plant growth and differentiation, but not their structurally similar analogs, were identified to enhance primary mouse CD4(+) T cell activation in conjunction with soluble anti-CD3 stimulation: Indoleacetic acid (natural plant auxin), 1-Napthaleneacetic acid (synthetic plant auxin) and 2,4-Dichlorophenoxyacetic acid (synthetic plant auxin and herbicide). These effects are distinct in comparison to Curcumin, the well known phenolic immunomodulator, which lowers T cell activation. An investigation into the mechanisms of action of the three plant growth regulators revealed a rapid induction of reactive oxygen species (ROS), mainly comprising H(2)O(2). In addition, these three molecules synergize with soluble anti-CD3 signaling to enhance intracellular Ca(2+) concentrations [Ca(2+)](i), leading to greater T cell activation, e.g. induction of CD25 and IL-2. Enhanced production of TNFα and IFNγ by CD4(+) T cells is also observed upon plant growth regulator treatment with soluble anti-CD3. Interestingly, maximal IL-2 production and CD4(+) T cell cycle progression are observed upon activation with soluble anti-CD3 and phorbol 12-myristate 13-acetate (PMA), a phorbol ester. Additionally, stimulation with PMA and Ionomcyin (a Ca(2+) ionophore), which activates T cells by circumventing the TCR, and plant growth regulators also demonstrated the role of the strength of signal (SOS): T cell cycle progression is enhanced with gentle activation conditions but decreased with strong activation conditions. This study demonstrates the direct effects of three plant growth regulators on CD4(+) T cell activation and cycling.

  20. Nitric Oxide Synthase 1 Modulates Basal and β-Adrenergic-Stimulated Contractility by Rapid and Reversible Redox-Dependent S-Nitrosylation of the Heart. (United States)

    Vielma, Alejandra Z; León, Luisa; Fernández, Ignacio C; González, Daniel R; Boric, Mauricio P


    S-nitrosylation of several Ca2+ regulating proteins in response to β-adrenergic stimulation was recently described in the heart; however the specific nitric oxide synthase (NOS) isoform and signaling pathways responsible for this modification have not been elucidated. NOS-1 activity increases inotropism, therefore, we tested whether β-adrenergic stimulation induces NOS-1-dependent S-nitrosylation of total proteins, the ryanodine receptor (RyR2), SERCA2 and the L-Type Ca2+ channel (LTCC). In the isolated rat heart, isoproterenol (10 nM, 3-min) increased S-nitrosylation of total cardiac proteins (+46±14%) and RyR2 (+146±77%), without affecting S-nitrosylation of SERCA2 and LTCC. Selective NOS-1 blockade with S-methyl-L-thiocitrulline (SMTC) and Nω-propyl-l-arginine decreased basal contractility and relaxation (-25-30%) and basal S-nitrosylation of total proteins (-25-60%), RyR2, SERCA2 and LTCC (-60-75%). NOS-1 inhibition reduced (-25-40%) the inotropic response and protein S-nitrosylation induced by isoproterenol, particularly that of RyR2 (-85±7%). Tempol, a superoxide scavenger, mimicked the effects of NOS-1 inhibition on inotropism and protein S-nitrosylation; whereas selective NOS-3 inhibitor L-N5-(1-Iminoethyl)ornithine had no effect. Inhibition of NOS-1 did not affect phospholamban phosphorylation, but reduced its oligomerization. Attenuation of contractility was abolished by PKA blockade and unaffected by guanylate cyclase inhibition. Additionally, in isolated mouse cardiomyocytes, NOS-1 inhibition or removal reduced the Ca2+-transient amplitude and sarcomere shortening induced by isoproterenol or by direct PKA activation. We conclude that 1) normal cardiac performance requires basal NOS-1 activity and S-nitrosylation of the calcium-cycling machinery; 2) β-adrenergic stimulation induces rapid and reversible NOS-1 dependent, PKA and ROS-dependent, S-nitrosylation of RyR2 and other proteins, accounting for about one third of its inotropic effect.

  1. Clinical utility of RapidArcTM radiotherapy technology

    Directory of Open Access Journals (Sweden)

    Infusino E


    Full Text Available Erminia Infusino Department of Radiotherapy, Campus Bio-Medico University Hospital, Rome, Italy Abstract: RapidArcTM is a radiation technique that delivers highly conformal dose distributions through the complete rotation (360° and speed variation of the linear accelerator gantry. This technique, called volumetric modulated arc therapy (VMAT, compared with conventional radiotherapy techniques, can achieve high-target volume coverage and sparing damage to normal tissues. RapidArc delivers precise dose distribution and conformity similar to or greater than intensity-modulated radiation therapy in a short time, generally a few minutes, to which image-guided radiation therapy is added. RapidArc has become a currently used technology in many centers, which use RapidArc technology to treat a large number of patients. Large and small hospitals use it to treat the most challenging cases, but more and more frequently for the most common cancers. The clinical use of RapidArc and VMAT technology is constantly growing. At present, a limited number of clinical data are published, mostly concerning planning and feasibility studies. Clinical outcome data are increasing for a few tumor sites, even if only a little. The purpose of this work is to discuss the current status of VMAT techniques in clinical use through a review of the published data of planning systems and clinical outcomes in several tumor sites. The study consisted of a systematic review based on analysis of manuscripts retrieved from the PubMed, BioMed Central, and Scopus databases by searching for the keywords "RapidArc", "Volumetric modulated arc radiotherapy", and "Intensity-modulated radiotherapy". Keywords: IMRT, VMAT, SBRT, SRS, treatment planning software 

  2. Capacity-achieving CPM schemes

    CERN Document Server

    Perotti, Alberto; Benedetto, Sergio; Montorsi, Guido


    The pragmatic approach to coded continuous-phase modulation (CPM) is proposed as a capacity-achieving low-complexity alternative to the serially-concatenated CPM (SC-CPM) coding scheme. In this paper, we first perform a selection of the best spectrally-efficient CPM modulations to be embedded into SC-CPM schemes. Then, we consider the pragmatic capacity (a.k.a. BICM capacity) of CPM modulations and optimize it through a careful design of the mapping between input bits and CPM waveforms. The so obtained schemes are cascaded with an outer serially-concatenated convolutional code to form a pragmatic coded-modulation system. The resulting schemes exhibit performance very close to the CPM capacity without requiring iterations between the outer decoder and the CPM demodulator. As a result, the receiver exhibits reduced complexity and increased flexibility due to the separation of the demodulation and decoding functions.

  3. Radiotherapy for large cutaneous angiosarcoma of face with RapidArc (VMAT

    Directory of Open Access Journals (Sweden)

    Mirza Athar Ali


    Full Text Available Angiosarcoma is a rare malignancy of vascular origin. It can affect any part of the body, head and neck region being probably the most common site of diagnosis. We present here a case of Angiosarcoma of face in a 67-year-old elderly gentleman who was treated with RapidArc – volumetric modulated arc therapy (VMAT for recurrence after surgery, radiotherapy and chemotherapy. As an alternative to Electron Beam Therapy, RapidArc with skin bolus can be considered for large complex shaped targets with irregular surface and tissue inhomogeneity. RapidArc plan can achieve adequate target coverage with acceptable dose homogeneity and conformity.

  4. NREL module energy rating methodology

    Energy Technology Data Exchange (ETDEWEB)

    Whitaker, C.; Newmiller, J.; Kroposki, B. [National Renewable Energy Laboratory, Golden, CO (United States)] [and others


    The goals of this project were to develop a tool for: evaluating one module in different climates; comparing different modules; provide a Q&D method for estimating periodic energy production; provide an achievable module rating; provide an incentive for manufacturers to optimize modules to non-STC conditions; and to have a consensus-based, NREL-sponsored activity. The approach taken was to simulate module energy for five reference days of various weather conditions. A performance model was developed.

  5. Pulse-width modulation pre-emphasis applied in a wireline transmitter, achieving 33 dB loss compensation at 5-Gb/s in 0.13-/spl mu/m CMOS

    NARCIS (Netherlands)

    Schrader, J.H.R.; Klumperink, E.A.M.; Visschers, J.L.; Nauta, B.


    A transmitter pre-emphasis technique for copper cable equalization is presented that is based on pulse-width modulation (PWM). This technique is an alternative to the usual 2-tap symbol-spaced FIR (SSF) pre-emphasis. The technique uses timing resolution instead of amplitude resolution to adjust the

  6. GWDC Achieved Rapid Development in Domestic and International Market

    Institute of Scientific and Technical Information of China (English)

    Yang Ming; Chang Xin


    @@ Greatwall Drilling Company (GWDC), an integrated petroleum engineering services company, mainly provides general contracting services of well construction for oiifield development. The company devotes major efforts to reservoir geographical study, acid fracturing treatment of formations, gas development, and other related technical extension services for oilfield development.

  7. Leader as achiever. (United States)

    Dienemann, Jacqueline


    This article examines one outcome of leadership: productive achievement. Without achievement one is judged to not truly be a leader. Thus, the ideal leader must be a visionary, a critical thinker, an expert, a communicator, a mentor, and an achiever of organizational goals. This article explores the organizational context that supports achievement, measures of quality nursing care, fiscal accountability, leadership development, rewards and punishments, and the educational content and teaching strategies to prepare graduates to be achievers.

  8. Polarisation Encryption/Decryption Module

    DEFF Research Database (Denmark)


    A polarisation encryption/decryption module comprising at least two array based modulating devices, preferably spatial light modulators (SLMs), at least one array based intensity detector, and at least one source of electromagnetic radiation. A local region of information displayed on a first of ...... rapidly. May be used for real time encryption/decryption of motion pictures. Further, a method of polarisation encrypting and decrypting information. The encryption/decryption is performed optically while the communication is performed electronically....

  9. 大规模RapidIO协议交换的FPGA实现%An Implementation of Large Scale RapidIO Switch on FPGA

    Institute of Scientific and Technical Information of China (English)

    翟彦彬; 蒋志焱; 张保宁


    RapidIO交换模块是RapidIO系统的核心模块,决定了整个RapidIO系统的数据带宽.文中介绍了一种大规模RapidIO协议交换的FPGA实现方式,并且在基于VPX总线的RapidIO交换模块中得到实际应用.该交换模块除具有RapidIO协议交换功能,还具有RapidIO系统主控功能以及以太网交换功能.经过使用实际的RapidIO端点模块进行测试,该交换模块实现了RapidIO交换功能以及RapidIO系统主控功能.%A RapidIO switch module is the key of a RapidIO system and affects the bandwidth of the whole RapidIO system. An implementation of large scale RapidIO switch on FPGA is introduced and applied in a RapidIO switch module based on VPX bus. This switch module implements RapidIO host function and Ethernet switch function as well as RapidIO switch function. The RapidIO switch module is tested with RapidIO endpoint module. This switch modle implements RapidIO host function as well as RapidIO switch function.

  10. -Regular Modules

    Directory of Open Access Journals (Sweden)

    Areej M. Abduldaim


    Full Text Available We introduced and studied -regular modules as a generalization of -regular rings to modules as well as regular modules (in the sense of Fieldhouse. An -module is called -regular if for each and , there exist and a positive integer such that . The notion of -pure submodules was introduced to generalize pure submodules and proved that an -module is -regular if and only if every submodule of is -pure iff   is a -regular -module for each maximal ideal of . Many characterizations and properties of -regular modules were given. An -module is -regular iff is a -regular ring for each iff is a -regular ring for finitely generated module . If is a -regular module, then .

  11. CMOS Compatible Ultra-Compact Modulator

    DEFF Research Database (Denmark)

    Babicheva, Viktoriia; Kinsey, Nathaniel; Naik, Gururaj V.


    A planar layout for an ultra-compact plasmonic modulator is proposed and numerically investigated. Our device utilizes potentially CMOS compatible materials and can achieve 3-dB modulation in just 65nm and insertion loss <1dB at telecommunication wavelengths.......A planar layout for an ultra-compact plasmonic modulator is proposed and numerically investigated. Our device utilizes potentially CMOS compatible materials and can achieve 3-dB modulation in just 65nm and insertion loss


    Institute of Scientific and Technical Information of China (English)

    Hu Jianwei; Yang Shaoquan


    The relationship between Haar wavelet decomposition coefficients and modulated signal parameters is discussed. A new modulation classification method is presented. The new method uses the amplitude,frequency and phase information derived from Haar wavelet decomposition as feature vectors to distinguish the modulation types of M-ary Frequency-Shift Keying (MFSK), M-ary Phase-Shift Keying (MPSK) and Quadrature Amplitude Modulation (QAM) modulation types. A parallel combined classifier is designed based on these feature vectors. The overall successful recognition rate of 92.4% can be achieved even at a low Signal-to-Noise Ratio (SNR) of 5dB.

  13. Mechanical models of amplitude and frequency modulation

    Energy Technology Data Exchange (ETDEWEB)

    Bellomonte, L; Guastella, I; Sperandeo-Mineo, R M [GRIAF - Research Group on Teaching/Learning Physics, DI.F.TE.R. -Dipartimento di Fisica e Tecnologie Relative, University of Palermo, Viale delle Scienze, Edificio 18, 90128 Palermo (Italy)


    This paper presents some mechanical models for amplitude and frequency modulation. The equations governing both modulations are deduced alongside some necessary approximations. Computer simulations of the models are carried out by using available educational software. Amplitude modulation is achieved by using a system of two weakly coupled pendulums, whereas the frequency modulation is obtained by using a pendulum of variable length. Under suitable conditions (small oscillations, appropriate initial conditions, etc) both types of modulation result in significantly accurate and visualized simulations.

  14. Exploiting total internal reflection geometry for efficient optical modulation of terahertz light (United States)

    Liu, Xudong; Parrott, Edward P. J.; Ung, Benjamin S.-Y.; Pickwell-MacPherson, Emma


    Efficient methods to modulate terahertz (THz) light are essential for realizing rapid THz imaging and communication applications. Here we report a novel THz modulator which utilizes the evanescent wave in a total internal reflection setup coupled with a conductive interface to enhance the attenuation efficiency of THz light. This approach makes it possible to achieve close to 100% modulation with a small interface conductivity of 12 mS. The frequency dependence of this technique is linked to the optical properties of the materials: a material with close to frequency independent conductivity that is also controllable will result in an achromatic modulation response, and the device performance can be optimized further by tuning the internal reflection angle. In this work, we focus on applying the technique in the terahertz frequency range. Using an LED array with a pump intensity of 475 mW/cm2 to produce carriers in a silicon wafer, we have achieved a modulation depth of up to 99.9% in a broad frequency range of 0.1 THz-0.8 THz. The required pumping power for the generation of the required free carriers is low because the sheet conductivity needed is far less than required for traditional transmission techniques. Consequently, the device can be modulated by an LED making it a very practical, low cost, and scalable solution for THz modulation.

  15. Exploiting total internal reflection geometry for efficient optical modulation of terahertz light

    Directory of Open Access Journals (Sweden)

    Xudong Liu


    Full Text Available Efficient methods to modulate terahertz (THz light are essential for realizing rapid THz imaging and communication applications. Here we report a novel THz modulator which utilizes the evanescent wave in a total internal reflection setup coupled with a conductive interface to enhance the attenuation efficiency of THz light. This approach makes it possible to achieve close to 100% modulation with a small interface conductivity of 12 mS. The frequency dependence of this technique is linked to the optical properties of the materials: a material with close to frequency independent conductivity that is also controllable will result in an achromatic modulation response, and the device performance can be optimized further by tuning the internal reflection angle. In this work, we focus on applying the technique in the terahertz frequency range. Using an LED array with a pump intensity of 475 mW/cm2 to produce carriers in a silicon wafer, we have achieved a modulation depth of up to 99.9% in a broad frequency range of 0.1 THz–0.8 THz. The required pumping power for the generation of the required free carriers is low because the sheet conductivity needed is far less than required for traditional transmission techniques. Consequently, the device can be modulated by an LED making it a very practical, low cost, and scalable solution for THz modulation.

  16. Simulation Analysis Module of High-speed Rail Bearings Based on Secondary Development in ADAMS

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li; YE Jun; XU Juan; LUO Yi-chao


    This paper develops a strong secondary development based on ADAMS feature which creates high-speed rail bearings for simulation analysis module. This thesis is in the case of non-circular pattern instructions of how to achieve rapid roller modeling, with analysis of functions and parameters required for the design of the simulation module of the high-speed rail bearing , as well as the design of dialog boxes, the environment and file structure. The specific modules is based on the secondary development language provided by ADAMS/View. Through the menus, dialog boxes which input parameters, it can achieve high iron bearing automatic modeling, dynamic analysis and post-processing to simplify the analysis of high-speed rail bearing operations, as well as improving the high-speed rail bearing development efficiency.

  17. Fiscal 2000 achievement report on the venture business assisting type regional consortium - Minor business creation base type. Development of 1-chip multifunctional motion sensor and its application to intelligent module; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. 1 chip gata takino undo sensor no kaihatsu to intelligent module eno tekiyo

    Energy Technology Data Exchange (ETDEWEB)



    The aim is to embody an intelligent micromodule for sensing bodily motions. For this purpose, technologies were established for high accuracy/high aspect ratio etching of crystals and for detecting angular velocity and acceleration, and a 1-chip multifunctional motion sensor was developed. The results of the efforts are briefly described below. A 1-chip multifunctional motion sensor (device size: 16 times 6 times 0.3mm) was developed, capable of simultaneously detecting uniaxial acceleration and uniaxial angular velocity, and an operating circuit was established for the detection. Using the 1-chip multifunctional motion sensor, a wrist watch type intelligent module was developed, capable of discriminating between various patterns of human behavior (walking, jogging, desk work, etc.). An intelligent module and the host computer were connected by wire or radio enabling the real-time observation of a patient's kinetic behavior, and this helped develop an application program allowing the quantification of the rate of recovery of patients undergoing rehabilitation. Using an intelligent module, an application program was developed enabling a laryngeal patient to establish communication by a physical action in case of emergency. (NEDO)

  18. Graphene liquid marbles as photothermal miniature reactors for reaction kinetics modulation. (United States)

    Gao, Wei; Lee, Hiang Kwee; Hobley, Jonathan; Liu, Tianxi; Phang, In Yee; Ling, Xing Yi


    We demonstrate the fabrication of graphene liquid marbles as photothermal miniature reactors with precise temperature control for reaction kinetics modulation. Graphene liquid marbles show rapid and highly reproducible photothermal behavior while maintaining their excellent mechanical robustness. By tuning the applied laser power, swift regulation of graphene liquid marble's surface temperature between 21-135 °C and its encapsulated water temperature between 21-74 °C are demonstrated. The temperature regulation modulates the reaction kinetics in our graphene liquid marble, achieving a 12-fold superior reaction rate constant for methylene blue degradation than at room temperature.

  19. Rapid roadway development

    Energy Technology Data Exchange (ETDEWEB)

    David Hainsworth [CSIRO Exploration & Mining (Australia)


    A new mining machine, the ACBM, has been developed, which will demonstrate new technologies and will act as a platform for further research and development. With the advent of the ACARP Roadway Development Task Group and the CM2010 project, an ACARP initiative to develop a new mining machine that can operate for 20 hours per day at 10m per hour development rate, it is believed that the Autonomous Conveyor Bolter Module (ACBM) will remain a key potential building block to meet certain CM2010 project targets. The bolt storage and delivery system has been found to be appropriate for further investigation and development as part of ongoing CM2010 studies. This final project reports and discusses the successes of the project; examines the reasons for failure to achieve the initial project objectives; shows how reduced scope objectives were defined; and describes the learnings from this project which will provide a positive influence to the direction of future work.

  20. Economic Growth——"Sound and Rapid" Development

    Institute of Scientific and Technical Information of China (English)



    Sound and rapid development is an intrinsic requirement in the implementation of the "scientific outlook on development" and represents an important change in the concept of economic development. This article, reviews past achievements under the guidance of "rapid and sound" development, and brings to light the reasons why we need to pursue "sound and rapid" development and how it can be achieved.

  1. 'No delays achiever'. (United States)


    The latest version of the NHS Institute for Innovation and Improvement's 'no delays achiever', a web based tool created to help NHS organisations achieve the 18-week target for GP referrals to first treatment, is available at

  2. XPM-induced degradation of multilevel phase modulated channel caused by neighboring NRZ modulated channels

    DEFF Research Database (Denmark)

    Jensen, Jesper Bevensee; Schiellerup, G.; Peucheret, Christophe


    The impact of XPM from NRZ modulated channels on an 8-level phase modulated channel in a WDM system was investigated. Requirements on launch power are found. 400 km transmission was achieved with negligible penalty.......The impact of XPM from NRZ modulated channels on an 8-level phase modulated channel in a WDM system was investigated. Requirements on launch power are found. 400 km transmission was achieved with negligible penalty....

  3. Prostate treatments, 1MRT o RapidArc; Tratamiento de prostata, IMART o RapidArc?

    Energy Technology Data Exchange (ETDEWEB)

    Castro novais, J.; Ruiz Maqueda, S.; Pardo Perez, E.; Molina Lopez, M. Y.; Cerro Penalver, E.


    Techniques that modulate the dose (as IMRT or RapidArcTM) improve dose homogeneity within the target volume decreasing the dose in healthy organs. The aim of this work is to study the dosimetric differences in prostate radiotherapy treatments with IMRT and RapidArcTM. The results of the 109 patients studied show that plans to RapidArcTM have better coverage, compliance and dose gradient outside the target volume. (Author)

  4. Human Physiology: Improving Students' Achievements through Intelligent Studyware. (United States)

    Dori, Yehudit J.; Yochim, Jerome M.


    A studyware comprising a set of interconnected modules on human physiology has been developed and used to improve undergraduate students' achievements. Study results show the scores of students who used the optional computer laboratory sessions were enhanced over those who did not use the studyware. Presents examples from the modules. (LZ)

  5. Optimization of verification pretreatment of plans of radiotherapy treatment with the technique of arcoterapia with RapidArc VMAT intensity-modulated; Optimizacion de la verificacion pretratamiento de los planes de tratamiento radioterapico con la tecnica de arcoterapia con intensidad modulada RapidArc VMAT

    Energy Technology Data Exchange (ETDEWEB)

    Serna Berna, A.; Puchades Puchades, V.; Mata Cologro, F.; Ramos Amores, D.


    The pretreatment verification of plans arcoterapia intensity modulated (VMAT) increases the workload on the services of radio physics. These checks focus with two objectives: First, check the dose calculation system for treatment planning; and second verify that the accelerator is able to administer treatment as has been planned. There are different commercial solutions to facilitate this procedure. The purpose of this paper is to compare the efficiency of four sets of independent verification to establish an optimal protocol. (Author)

  6. Rapid coal proximate analysis by thermogravimetric method

    Energy Technology Data Exchange (ETDEWEB)

    Mao Jianxiong; Yang Dezhong; Zhao Baozhong


    A rapid coal proximate analysis by thermogravimetric analysis (TGA) can be used as an alternative method for the standard proximate analysis. This paper presents a program set up to rapidly perform coal proximate analysis by using a thermal analyzer and TGA module. A comparison between coal proximate analyses by standard method (GB) and TGA is also given. It shows that most data from TGA fall within the tolerance limit of standard method.

  7. Rapid shallow breathing (United States)

    Tachypnea; Breathing - rapid and shallow; Fast shallow breathing; Respiratory rate - rapid and shallow ... Shallow, rapid breathing has many possible medical causes, including: Asthma Blood clot in an artery in the lung Choking Chronic obstructive ...

  8. Rapid generation of light beams carrying orbital angular momentum. (United States)

    Mirhosseini, Mohammad; Magaña-Loaiza, Omar S; Chen, Changchen; Rodenburg, Brandon; Malik, Mehul; Boyd, Robert W


    We report a technique for encoding both amplitude and phase variations onto a laser beam using a single digital micro-mirror device (DMD). Using this technique, we generate Laguerre-Gaussian and vortex orbital-angular-momentum (OAM) modes, along with modes in a set that is mutually unbiased with respect to the OAM basis. Additionally, we have demonstrated rapid switching among the generated modes at a speed of 4 kHz, which is much faster than the speed regularly achieved by phase-only spatial light modulators (SLMs). The dynamic control of both phase and amplitude of a laser beam is an enabling technology for classical communication and quantum key distribution (QKD) systems that employ spatial mode encoding.

  9. UGV application modeling and sensor simulation using a rapid prototyping testbed environment (United States)

    Falasco, James; O'Leary, Steve


    This paper reviews hardware and software solutions that allow for rapid prototyping of new or modified UGV sensor designs, mission payloads and functional sub assemblies. We define reconfigurable computing in the context of being able to place various PMC modules depending upon mission scenarios onto a base SBC (Single Board Computer) or multiprocessor architectures to achieve maximum scalability. Also addressed are the sensor and computing packaging aspects and how such payloads could be integrated with unattended acoustic sensor topologies providing a more complete fused "picture" to decision makers. We review how these modular payloads could be integrated with unattended ground sensors to collaborate on mission requirements

  10. Achieving Strategic Battlespace Awareness. (United States)


    provided through technologies developed in the Rapid Terrain • Visualization ACTD. Imagery is draped over terrain elevation data to project a 3-D view of...Support Agency, C4I Handbook for Integrated Planning( CHIP )(Washington, D.C.: Office of the Assistant Secretary of Defense, Command, Control... CHIP ). Washington, D.C. Office of the Assistant Secretary of Defense, Command, Control, Communications, and Intelligence, January 1995. Clancy, Tom

  11. NCLB: Achievement Robin Hood? (United States)

    Bracey, Gerald W.


    In his "Wall Street Journal" op-ed on the 25th of anniversary of "A Nation At Risk", former assistant secretary of education Chester E. Finn Jr. applauded the report for turning U.S. education away from equality and toward achievement. It was not surprising, then, that in mid-2008, Finn arranged a conference to examine the…

  12. Cognitive Processes and Achievement. (United States)

    Hunt, Dennis; Randhawa, Bikkar S.

    For a group of 165 fourth- and fifth-grade students, four achievement test scores were correlated with success on nine tests designed to measure three cognitive functions: sustained attention, successive processing, and simultaneous processing. This experiment was designed in accordance with Luria's model of the three functional units of the…

  13. Comparison of dosimetry achieved using volumetric modulated arc therapy or static intensity-modulated radiotherapy to treat esophageal neoplasm%食管癌静态调强放疗与容积调强弧形放疗计划的剂量学比较

    Institute of Scientific and Technical Information of China (English)

    何志杰; 王晓敏; 赵一电; 孙秀珂; 王慧涛; 张强; 陈龙


    Objective To compare the feasibility of using volumetric modulated arc therapy (VMAT)or static intensity-modulated radiotherapy (IMRT)to treat advanced esophageal neoplasm. Methods A consecutive series of 37 patients newly diagnosed with esophageal neoplasm was analyzed by computed tomography,and the resulting images were input into the oncentra planning system to generate protocols for IMRT and VMAT. All 37 patients received both types of treatment. Dose-volume histograms were generated to compare gross tumor volume (GTV),planning target volume (PTV) and exposure of at-risk organs. Different results for each method were assessed for statistical significance using the paired t-test. Results VMAT gave slightly but not significantly higher values than IMRT for PTV-D98 (58.39±1.03 vs 58.51±0.57,P=0.314)and PTV-D2 (65.92±1.57 vs 66.17±1.25,P=0.230). VMAT was associated with significantly lower GTV D98 (60.03±1.23 vs 62.46±1.03,P<0.001),D2 (64.83±0.91 vs 66.08±1.01,P=0.001), and Dmean(63.62±1.28 vs 64.07±1.08,P=0.021). VMAT also gave significantly lower PTV-V105 coverage(t=-8.216,P<0.001). The two methods were associated with similar conformity index(t=-0.147,P=0.884),homogeneity index(t=2.56,P=0.89),spinal dose (P=0.743)and heart dose (P=0.519). VMAT was associated with lower lung V20 than IMRT (t=-12.690,P<0.001),as well as lower lung V30(t=-2.870,P=0.007)and lower mean lung dose(t=-3.659,P=0.001). Mean MU was 24% lower with VMAT than with IMRT (572.33 vs 754.95). Conclusion In patients with esophageal neoplasms,VMAT can provide equivalent or superior dose distributions compared to IMRT,and it can generate more and better GTV hotspots. VMAT is also associated with lower lung V20 and V30,lower MU,and higher delivery efficiency. These findings suggest that VMAT has strong potential for treating esophageal cancer.%目的:研究食管癌患者应用静态调强放疗(static intensity modulate radiotherapy,sIMRT)和


    Energy Technology Data Exchange (ETDEWEB)

    Miller, N. J.; Marriage, T. A.; Appel, J. W.; Bennett, C. L.; Eimer, J.; Essinger-Hileman, T.; Harrington, K.; Rostem, K.; Watts, D. J. [Department of Physics and Astronomy, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218 (United States); Chuss, D. T. [Department of Physics, Villanova University, 800 E Lancaster, Villanova, PA 19085 (United States); Wollack, E. J.; Fixsen, D. J.; Moseley, S. H.; Switzer, E. R., E-mail: [Observational Cosmology Laboratory, Code 665, NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States)


    Variable-delay Polarization Modulators (VPMs) are currently being implemented in experiments designed to measure the polarization of the cosmic microwave background on large angular scales because of their capability for providing rapid, front-end polarization modulation and control over systematic errors. Despite the advantages provided by the VPM, it is important to identify and mitigate any time-varying effects that leak into the synchronously modulated component of the signal. In this paper, the effect of emission from a 300 K VPM on the system performance is considered and addressed. Though instrument design can greatly reduce the influence of modulated VPM emission, some residual modulated signal is expected. VPM emission is treated in the presence of rotational misalignments and temperature variation. Simulations of time-ordered data are used to evaluate the effect of these residual errors on the power spectrum. The analysis and modeling in this paper guides experimentalists on the critical aspects of observations using VPMs as front-end modulators. By implementing the characterizations and controls as described, front-end VPM modulation can be very powerful for mitigating 1/f noise in large angular scale polarimetric surveys. None of the systematic errors studied fundamentally limit the detection and characterization of B-modes on large scales for a tensor-to-scalar ratio of r = 0.01. Indeed, r < 0.01 is achievable with commensurately improved characterizations and controls.

  15. Implementing RapidArc into clinical routine

    DEFF Research Database (Denmark)

    Van Esch, Ann; Huyskens, Dominique P; Behrens, Claus F;


    With the increased commercial availability of intensity modulated arc therapy (IMAT) comes the need for comprehensive QA programs, covering the different aspects of this newly available technology. This manuscript proposes such a program for the RapidArc (RA) (Varian Medical Systems, Palo Alto...

  16. Superconducting optical modulator (United States)

    Bunt, Patricia S.; Ference, Thomas G.; Puzey, Kenneth A.; Tanner, David B.; Tache, Nacira; Varhue, Walter J.


    An optical modulator based on the physical properties of high temperature superconductors has been fabricated and tested. The modulator was constructed form a film of Yttrium Barium Copper Oxide (YBCO) grown on undoped silicon with a buffer layer of Yttria Stabilized Zirconia. Standard lithographic procedures were used to pattern the superconducting film into a micro bridge. Optical modulation was achieved by passing IR light through the composite structure normal to the micro bridge and switching the superconducting film in the bridge region between the superconducting and non-superconducting states. In the superconducting state, IR light reflects from the superconducting film surface. When a critical current is passed through the micro bridge, it causes the film in this region to switch to the non-superconducting state allowing IR light to pass through it. Superconducting materials have the potential to switch between these two states at speeds up to 1 picosecond using electrical current. Presently, fiber optic transmission capacity is limited by the rate at which optical data can be modulated. The superconducting modulator, when combined with other components, may have the potential to increase the transmission capacity of fiber optic lines.

  17. The Rapid Transient Surveyor (United States)

    Baranec, Christoph; Tonry, John; Wright, Shelley; Tully, R. Brent; Lu, Jessica R.; Takamiya, Marianne Y.; Hunter, Lisa


    The next decade of astronomy will be dominated by large area surveys (see the detailed discussion in the Astro-2010 Decadal survey and NRC's recent OIR System Report). Ground-based optical transient surveys, e.g., LSST, ZTF and ATLAS and space-based exoplanet, supernova, and lensing surveys such as TESS and WFIRST will join the Gaia all-sky astrometric survey in producing a flood of data that will enable leaps in our understanding of the universe. There is a critical need for further characterization of these discoveries through high angular resolution images, deeper images, spectra, or observations at different cadences or periods than the main surveys. Such follow-up characterization must be well matched to the particular surveys, and requires sufficient additional observing resources and time to cover the extensive number of targets.We describe plans for the Rapid Transient Surveyor (RTS), a permanently mounted, rapid-response, high-cadence facility for follow-up characterization of transient objects on the U. of Hawai'i 2.2-m telescope on Maunakea. RTS will comprise an improved robotic laser adaptive optics system, based on the prototype Robo-AO system (formerly at the Palomar 1.5-m and now at the Kitt Peak 2.2-m telescope), with simultaneous visible and near-infrared imagers as well as a near-infrared integral field spectrograph (R~100, λ = 850 - 1830 nm, 0.15″ spaxels, 8.7″×6.0″ FoV). RTS will achieve an acuity of ~0.07″ in visible wavelengths and automated detection and characterization of astrophysical transients during a sustained observing campaign will yield the necessary statistics to precisely map dark matter in the local universe.

  18. Rapid geophysical surveyor

    Energy Technology Data Exchange (ETDEWEB)

    Roybal, L.G.; Carpenter, G.S.; Josten, N.E.


    The Rapid Geophysical Surveyor (RGS) is a system designed to rapidly and economically collect closely-spaced geophysical data used for characterization of Department of Energy (DOE) waste sites. Geophysical surveys of waste sites are an important first step in the remediation and closure of these sites; especially older sties where historical records are inaccurate and survey benchmarks have changed due to refinements in coordinate controls and datum changes. Closely-spaced data are required to adequately differentiate pits, trenches, and soil vault rows whose edges may be only a few feet from each other. A prototype vehicle designed to collect magnetic field data was built at the Idaho national Engineering Laboratory (INEL) during the summer of 1992. The RGS was one of several projects funded by the Buried Waste Integrated Demonstration (BWID) program. This vehicle was demonstrated at the Subsurface Disposal Area (SDA) within the Radioactive Waste Management Complex (RWMC) on the INEL in September of 1992. Magnetic data were collected over two areas in the SDA, with a total survey area of about 1.7 acres. Data were collected at a nominal density of 2 1/2 inches along survey lines spaced 1 foot apart. Over 350,000 data points were collected over a 6 day period corresponding to about 185 man-days using conventional ground survey techniques. This report documents the design and demonstration of the RGS concept including the presentation of magnetic data collected at the SDA. The surveys were able to show pit and trench boundaries and determine details of their spatial orientation never before achieved.

  19. Rapid geophysical surveyor

    Energy Technology Data Exchange (ETDEWEB)

    Roybal, L.G.; Carpenter, G.S.; Josten, N.E.


    The Rapid Geophysical Surveyor (RGS) is a system designed to rapidly and economically collect closely-spaced geophysical data used for characterization of Department of Energy (DOE) waste sites. Geophysical surveys of waste sites are an important first step in the remediation and closure of these sites; especially older sties where historical records are inaccurate and survey benchmarks have changed due to refinements in coordinate controls and datum changes. Closely-spaced data are required to adequately differentiate pits, trenches, and soil vault rows whose edges may be only a few feet from each other. A prototype vehicle designed to collect magnetic field data was built at the Idaho national Engineering Laboratory (INEL) during the summer of 1992. The RGS was one of several projects funded by the Buried Waste Integrated Demonstration (BWID) program. This vehicle was demonstrated at the Subsurface Disposal Area (SDA) within the Radioactive Waste Management Complex (RWMC) on the INEL in September of 1992. Magnetic data were collected over two areas in the SDA, with a total survey area of about 1.7 acres. Data were collected at a nominal density of 2 1/2 inches along survey lines spaced 1 foot apart. Over 350,000 data points were collected over a 6 day period corresponding to about 185 man-days using conventional ground survey techniques. This report documents the design and demonstration of the RGS concept including the presentation of magnetic data collected at the SDA. The surveys were able to show pit and trench boundaries and determine details of their spatial orientation never before achieved.

  20. Single-exposure multiphoton fabrication of polygonized structures by an SLM-modulated Fresnel zone lens (United States)

    Zhang, Chenchu; Hu, Yanlei; Li, Jiawen; Lao, Zhaoxin; Xu, Bing; Ni, Jincheng; Cai, Ze; Wu, Dong; Chu, Jiaru


    Recently, annular beams have been developed to rapidly fabricate microscope tubular structures via two-photon polymerization, but the distribution of the light field is limited to a ring pattern. Here a Fresnel lens is designed and applied to modulate the light field into a uniform quadrangle or hexagon shape with controllable diameters. By applying a spatial light modulator to load the phase information of the Fresnel lens, quadrangle and hexagon structures are achieved through single exposure of a femtosecond laser. A 3×6 array of structures is made within 9 s. Comparing with the conventional holographic processing, this method shows higher uniformity, high efficiency, better flexibility, and easy operation. The approach exhibited a promising prospect in rapidly fabricating structures such as tissue engineering scaffolds and variously shaped tubular arrays.

  1. Achieveing Organizational Excellence Through

    Directory of Open Access Journals (Sweden)

    Mehdi Abzari


    Full Text Available AbstractToday, In order to create motivation and desirable behavior in employees, to obtain organizational goals,to increase human resources productivity and finally to achieve organizational excellence, top managers oforganizations apply new and effective strategies. One of these strategies to achieve organizational excellenceis creating desirable corporate culture. This research has been conducted to identify the path to reachorganizational excellence by creating corporate culture according to the standards and criteria oforganizational excellence. The result of the so-called research is this paper in which researchers foundtwenty models and components of corporate culture and based on the Industry, organizational goals andEFQM model developed a model called "The Eskimo model of Culture-Excellence". The method of theresearch is survey and field study and the questionnaires were distributed among 116 managers andemployees. To assess the reliability of questionnaires, Cronbach alpha was measured to be 95% in the idealsituation and 0/97 in the current situation. Systematic sampling was done and in the pre-test stage 45questionnaires were distributed. A comparison between the current and the ideal corporate culture based onthe views of managers and employees was done and finally it has been concluded that corporate culture isthe main factor to facilitate corporate excellence and success in order to achieve organizational effectiveness.The contribution of this paper is that it proposes a localized –applicable model of corporate excellencethrough reinforcing corporate culture.

  2. Irreducible Specht modules are signed Young modules


    Hemmer, David J.


    Recently Donkin defined signed Young modules as a simultaneous generalization of Young and twisted Young modules for the symmetric group. We show that in odd characteristic, if a Specht module $S^\\lambda$ is irreducible, then $S^\\lambda$ is a signed Young module. Thus the set of irreducible Specht modules coincides with the set of irreducible signed Young modules. This provides evidence for our conjecture that the signed Young modules are precisely the class of indecomposable self-dual module...

  3. Achievable Precision for Optical Ranging Systems (United States)

    Moision, Bruce; Erkmen, Baris I.


    Achievable RMS errors in estimating the phase, frequency, and intensity of a direct-detected intensity-modulated optical pulse train are presented. For each parameter, the Cramer-Rao-Bound (CRB) is derived and the performance of the Maximum Likelihood estimator is illustrated. Approximations to the CRBs are provided, enabling an intuitive understanding of estimator behavior as a function of the signaling parameters. The results are compared to achievable RMS errors in estimating the same parameters from a sinusoidal waveform in additive white Gaussian noise. This establishes a framework for a performance comparison of radio frequency (RF) and optical science. Comparisons are made using parameters for state-of-the-art deep-space RF and optical links. Degradations to the achievable errors due to clock phase noise and detector jitter are illustrated.

  4. Achieving form in autobiography

    Directory of Open Access Journals (Sweden)

    Nicholas (Nick Meihuizen


    Full Text Available This article argues that, unlike biographies which tend to follow patterns based on conventional expectations, salient autobiographies achieve forms unique to themselves. The article draws on ideas from contemporary formalists such as Peter McDonald and Angela Leighton but also considers ideas on significant form stemming from earlier writers and critics such as P.N. Furbank and Willa Cather. In extracting from these writers the elements of what they consider comprise achieved form, the article does not seek to provide a rigid means of objectively testing the formal attributes of a piece of writing. It rather offers qualitative reminders of the need to be alert to the importance of form, even if the precise nature of this importance is not possible to define. Form is involved in meaning, and this continuously opens up possibilities regarding the reader’s relationship with the work in question. French genetic critic Debray Genette distinguishes between ‘semantic effect’ (the direct telling involved in writing and ‘semiological effect’ (the indirect signification involved. It is the latter, the article argues in summation, which gives a work its singular nature, producing a form that is not predictable but suggestive, imaginative.

  5. *-Modules, co-*-modules and cotilting modules over Noetherian rings

    Institute of Scientific and Technical Information of China (English)

    汪明义; 许永华


    Let R be a Noetherian ring. The projectivity and injectivity of modules over R are discussed. The concept of modules is introduced and the descriptions for co-*-modules over R are given. At last, cotilting modules over R are characterized by means of co-*-modules.

  6. Thruster Module (United States)

    Andersson, G.


    The thruster module described in this paper provides a low but controlled acceleration in a mission which would normally be labelled “microgravity”. The first mission was Cryofenix, where tanks containing liquid hydrogen were used in the experiment. The experiment utilizing the low acceleration is using liquids and requires a precise acceleration profile throughout the mission. Acceleration obtained by payload rotation is not feasible due to that the transversal forces required to change the acceleration will cause undesired liquid turbulence. In order to satisfy the experiment requirements a thruster module was developed by SSC for the Cryofenix mission funded by CNES. The Cryofenix mission had a payload weight of 380 kg and an apogee of about 260 km. The module produces a controlled thrust in flight direction by means of a cold gas system.

  7. Rapid response systems update. (United States)

    Winterbottom, Fiona; Castex, Julie; Campbell, Anita


    Rapid response is a mature concept that is undergoing metamorphosis. The ideal structure and function of these safety teams has not yet been realized but new developments in the field of rapid response systems are evolving.

  8. Achieving diagnosis by consensus

    LENUS (Irish Health Repository)

    Kane, Bridget


    This paper provides an analysis of the collaborative work conducted at a multidisciplinary medical team meeting, where a patient’s definitive diagnosis is agreed, by consensus. The features that distinguish this process of diagnostic work by consensus are examined in depth. The current use of technology to support this collaborative activity is described, and experienced deficiencies are identified. Emphasis is placed on the visual and perceptual difficulty for individual specialities in making interpretations, and on how, through collaboration in discussion, definitive diagnosis is actually achieved. The challenge for providing adequate support for the multidisciplinary team at their meeting is outlined, given the multifaceted nature of the setting, i.e. patient management, educational, organizational and social functions, that need to be satisfied.

  9. Recognizing outstanding achievements (United States)

    Speiss, Fred

    One function of any professional society is to provide an objective, informed means for recognizing outstanding achievements in its field. In AGU's Ocean Sciences section we have a variety of means for carrying out this duty. They include recognition of outstanding student presentations at our meetings, dedication of special sessions, nomination of individuals to be fellows of the Union, invitations to present Sverdrup lectures, and recommendations for Macelwane Medals, the Ocean Sciences Award, and the Ewing Medal.Since the decision to bestow these awards requires initiative and judgement by members of our section in addition to a deserving individual, it seems appropriate to review the selection process for each and to urge you to identify those deserving of recognition.

  10. Achieving English Spoken Fluency

    Institute of Scientific and Technical Information of China (English)



    Language is first and foremost oral,spoken language,speaking skill is the most important one of the four skills(L,S,R,W)and also it is the most difficult one of the four skills. To have an all-round command of a language one must be able to speak and to understand the spoken language, it is not enough for a language learner only to have a good reading and writing skills. As Englisn language teachers, we need to focus on improving learners' English speaking skill to meet the need of our society and our country and provide learner some useful techniques to achieving their English spoken fluency. This paper focuses on the spoken how to improving learners speaking skill.

  11. Achieving closure at Fernald

    Energy Technology Data Exchange (ETDEWEB)

    Bradburne, John; Patton, Tisha C.


    When Fluor Fernald took over the management of the Fernald Environmental Management Project in 1992, the estimated closure date of the site was more than 25 years into the future. Fluor Fernald, in conjunction with DOE-Fernald, introduced the Accelerated Cleanup Plan, which was designed to substantially shorten that schedule and save taxpayers more than $3 billion. The management of Fluor Fernald believes there are three fundamental concerns that must be addressed by any contractor hoping to achieve closure of a site within the DOE complex. They are relationship management, resource management and contract management. Relationship management refers to the interaction between the site and local residents, regulators, union leadership, the workforce at large, the media, and any other interested stakeholder groups. Resource management is of course related to the effective administration of the site knowledge base and the skills of the workforce, the attraction and retention of qualified a nd competent technical personnel, and the best recognition and use of appropriate new technologies. Perhaps most importantly, resource management must also include a plan for survival in a flat-funding environment. Lastly, creative and disciplined contract management will be essential to effecting the closure of any DOE site. Fluor Fernald, together with DOE-Fernald, is breaking new ground in the closure arena, and ''business as usual'' has become a thing of the past. How Fluor Fernald has managed its work at the site over the last eight years, and how it will manage the new site closure contract in the future, will be an integral part of achieving successful closure at Fernald.

  12. Signed Young Modules and Simple Specht Modules


    Danz, Susanne; Lim, Kay Jin


    By a result of Hemmer, every simple Specht module of a finite symmetric group over a field of odd characteristic is a signed Young module. While Specht modules are parametrized by partitions, indecomposable signed Young modules are parametrized by certain pairs of partitions. The main result of this article establishes the signed Young module labels of simple Specht modules. Along the way we prove a number of results concerning indecomposable signed Young modules that are of independent inter...

  13. Memory Modulation

    NARCIS (Netherlands)

    Roozendaal, Benno; McGaugh, James L.


    Our memories are not all created equally strong: Some experiences are well remembered while others are remembered poorly, if at all. Research on memory modulation investigates the neurobiological processes and systems that contribute to such differences in the strength of our memories. Extensive evi

  14. Automatic modulation recognition of communication signals

    CERN Document Server

    Azzouz, Elsayed Elsayed


    Automatic modulation recognition is a rapidly evolving area of signal analysis. In recent years, interest from the academic and military research institutes has focused around the research and development of modulation recognition algorithms. Any communication intelligence (COMINT) system comprises three main blocks: receiver front-end, modulation recogniser and output stage. Considerable work has been done in the area of receiver front-ends. The work at the output stage is concerned with information extraction, recording and exploitation and begins with signal demodulation, that requires accurate knowledge about the signal modulation type. There are, however, two main reasons for knowing the current modulation type of a signal; to preserve the signal information content and to decide upon the suitable counter action, such as jamming. Automatic Modulation Recognition of Communications Signals describes in depth this modulation recognition process. Drawing on several years of research, the authors provide a cr...

  15. Achievement Goals and Achievement Emotions: A Meta-Analysis (United States)

    Huang, Chiungjung


    This meta-analysis synthesized 93 independent samples (N = 30,003) in 77 studies that reported in 78 articles examining correlations between achievement goals and achievement emotions. Achievement goals were meaningfully associated with different achievement emotions. The correlations of mastery and mastery approach goals with positive achievement…

  16. Vietnam: achievements and challenges. (United States)

    Tran Tien Duc


    The Vietnamese Government's successful development of the National Population and Family Planning Program has contributed in raising people's awareness on population issues and changing their attitudes and behavior regarding fostering small families. It has also been found to be very effective in substantially decreasing fertility level. In addition, economic levels of many households have been greatly improved since the adoption of a renovation policy. The advancement of welfare accompanied by the provision of better basic social services, including health services, has boost people's health. Several factors behind the achievements of the National Population and Family Planning Program include: 1) Strengthening of the political commitment of national and local leaders; 2) Nationwide mobilization of mass organizations and NGOs; 3) A strong advocacy and information, education and communication program; 4) Provision of various kinds of contraceptives; 5) Effective management of the program by priority; and 6) Support of the international community. Despite such successes, Vietnam is facing a number of new issues such as enlargement of the work force, shifting migration patterns and accelerating urbanization, aging of population, and change of household structure. Nevertheless, the Government of Vietnam is preparing a New Population Strategy aimed to address these issues.

  17. Self oscillating PWM modulators, a topological comparison

    DEFF Research Database (Denmark)

    Poulsen, Søren; Andersen, Michael Andreas E.


    High precision control of the output voltage or current of a switch mode converter with fast response is required for a number of applications. Dependent on the type of application, the desired precision and transient response can be difficult, if not impossible, to achieve with standard PWM...... control caused by limitations in dynamic capabilities which often limits fast tracking of a reference signal, or fast settling during load steps due to too small achievable control loop bandwidth. Achievable open loop bandwidth for standard voltage and current mode PWM modulators is typical in the fs/10...... to fs which makes this type of modulators an excellent choice for a wide range of applications. Self oscillating PWM modulators can be made in a number of ways, either as voltage or current mode modulators, and the self oscillating behavior can be achieved either by using hysteresis control...

  18. An integrated microfluidic platform for rapid tumor cell isolation, counting and molecular diagnosis. (United States)

    Hung, Lien-Yu; Chuang, Ying-Hsin; Kuo, Hsin-Tzu; Wang, Chih-Hung; Hsu, Keng-Fu; Chou, Cheng-Yang; Lee, Gwo-Bin


    Ovarian cancer is the second most common of the gynecological cancers in Taiwan. It is challenging to diagnose at an early stage when proper treatment is the most effective. It is well recognized that the detection of tumor cells (TCs) is critical for determining cancer growth stages and may provide important information for accurate diagnosis and even prognosis. In this study, a new microfluidic platform integrated with a moving-wall micro-incubator, a micro flow cytometer and a molecular diagnosis module performed automated identification of ovarian cancer cells. By efficiently mixing the cells and immunomagnetic beads coated with specific antibodies, the target TCs were successfully isolated from the clinical samples. Then counting of the target cells was achieved by a combination of the micro flow cytometer and an optical detection module and showed a counting accuracy as high as 92.5 %. Finally, cancer-associated genes were amplified and detected by the downstream molecular diagnosis module. The fluorescence intensity of specific genes (CD24 and HE4) associated with ovarian cancer was amplified by the molecular diagnosis module and the results were comparable to traditional slab-gel electrophoresis analysis, with a limit of detection around 10 TCs. This integrated microfluidic platform realized the concept of a "lab-on-a-chip" and had advantages which included automation, disposability, lower cost and rapid diagnosis and, therefore, may provide a promising approach for the fast and accurate detection of cancer cells.

  19. A minimum achievable PV electrical generating cost

    Energy Technology Data Exchange (ETDEWEB)

    Sabisky, E.S. [11 Carnation Place, Lawrenceville, NJ 08648 (United States)


    The role and share of photovoltaic (PV) generated electricity in our nation`s future energy arsenal is primarily dependent on its future production cost. This paper provides a framework for obtaining a minimum achievable electrical generating cost (a lower bound) for fixed, flat-plate photovoltaic systems. A cost of 2.8 $cent/kWh (1990$) was derived for a plant located in Southwestern USA sunshine using a cost of money of 8%. In addition, a value of 22 $cent/Wp (1990$) was estimated as a minimum module manufacturing cost/price

  20. Spatial light modulation in compound semiconductor materials (United States)

    Cheng, Li-Jen (Inventor); Gheen, Gregory O. (Inventor); Partovi, Afshin (Inventor)


    Spatial light modulation (22) in a III-V single crystal (12), e.g., gallium arsenide, is achieved using the photorefractive effect. Polarization rotation created by beam coupling is utilized in one embodiment. In particular, information (16)on a control beam (14) incident on the crystal is transferred to an input beam (10), also incident on the crystal. An output beam (18) modulated in intensity is obtained by passing the polarization-modulated input beam through a polarizer (20).

  1. Module Evaluation (United States)


    MODULES IN LIFE TEST CHAMBER (LEFT SIDE) 68 MODULE TRANSMIT TEMP CA1 54.8°C CB1 65.3°C CC1 70.5°C CD1 75.2°C CE1 68.5°C CA2 72.1°C CB2 ...NO. PA (Contractor) PA (MELTS) DRV (Contractor) DRV (MELTS) CA1 058 +11.0 VOLTS +10.3 VOLTS + 7.5 VOLTS + 3.64 VOLTS CB1 085 +11.0 VOLTS +10.13...CE1 032 +11.0 VOLTS + 7.02 VOLTS + 7.5 VOLTS + 4.23 VOLTS CA2 065 +11.0 VOLTS +11.03 VOLTS + 7.5 VOLTS + 7.53 VOLTS CB2 057 +11.0 VOLTS + 9.49


    identification has been achieved by using model modulation techniques to drive dynamic models into correspondence with operating control systems. The system ... identification then proceeded from examination of the model and the adaptive loop. The model modulation techniques applied to adaptive control

  3. Integrating Oracle Human Resources with Other Modules (United States)

    Sparks, Karl; Shope, Shawn


    One of the most challenging aspects of implementing an enterprise-wide business system is achieving integration of the different modules to the satisfaction of diverse customers. The Jet Propulsion Laboratory's (JPL) implementation of the Oracle application suite demonstrates the need to coordinate Oracle Human Resources Management System (HRMS) decision across the Oracle modules.

  4. Module descriptor

    DEFF Research Database (Denmark)

    Vincenti, Gordon; Klausen, Bodil; Kjær Jensen, Jesper


    The Module Descriptor including a Teacher’s Guide explains and describes how to work innovatively and co-creatively with wicked problems and young people. The descriptor shows how interested educators and lecturers in Europe can copy the lessons of the Erasmus+ project HIP when teaching their own...... students how to include marginalized young people and practitioners in the education of future social workers and social educators....

  5. CIM—Compact intensity modulation (United States)

    Bleuel, M.; Lang, E.; Gähler, R.; Lal, J.


    Compact intensity modulation (CIM), a new method to modulate the intensity of a neutron beam is demonstrated. CIM allows the production of arbitrary signals where the focus point can be chosen and changed without any constraints. A novel feature in this technique compared to spin echo techniques is that the neutron polarization is kept parallel or anti-parallel to the static fields during the passage through the magnetic fields and the beating pattern at the detector is produced by an amplitude modulation (AM) of the adiabatic RF-spin flippers rather than Larmor precession like in neutron spin echo (NSE) instruments; thus, the achievable contrast is very high and the instrument resolution can be changed very quickly. This gives the fascinating possibility at pulsed neutron sources to sweep the modulation frequency of the flippers in order to increase dynamic resolution range during the same neutron pulse.

  6. 160 Gb/s Silicon All-Optical Data Modulator based on Cross Phase Modulation

    DEFF Research Database (Denmark)

    Hu, Hao; Pu, Minhao; Ji, Hua


    We have demonstrated 160 Gb/s all-optical data modulation with an extinction ratio of 18.5 dB based on XPM in a silicon nanowire. Error free performance is achieved for the optically modulated 160 Gb/s signal.......We have demonstrated 160 Gb/s all-optical data modulation with an extinction ratio of 18.5 dB based on XPM in a silicon nanowire. Error free performance is achieved for the optically modulated 160 Gb/s signal....

  7. Rapid Prototyping Laboratory (United States)

    Federal Laboratory Consortium — The ARDEC Rapid Prototyping (RP) Laboratory was established in December 1992 to provide low cost RP capabilities to the ARDEC engineering community. The Stratasys,...

  8. Photovoltaic module and module arrays (United States)

    Botkin, Jonathan; Graves, Simon; Lenox, Carl J. S.; Culligan, Matthew; Danning, Matt


    A photovoltaic (PV) module including a PV device and a frame. The PV device has a PV laminate defining a perimeter and a major plane. The frame is assembled to and encases the laminate perimeter, and includes leading, trailing, and side frame members, and an arm that forms a support face opposite the laminate. The support face is adapted for placement against a horizontal installation surface, to support and orient the laminate in a non-parallel or tilted arrangement. Upon final assembly, the laminate and the frame combine to define a unitary structure. The frame can orient the laminate at an angle in the range of from horizontal, and can be entirely formed of a polymeric material. Optionally, the arm incorporates integral feature(s) that facilitate interconnection with corresponding features of a second, identically formed PV module.

  9. Attitude Towards Physics and Additional Mathematics Achievement Towards Physics Achievement (United States)

    Veloo, Arsaythamby; Nor, Rahimah; Khalid, Rozalina


    The purpose of this research is to identify the difference in students' attitude towards Physics and Additional Mathematics achievement based on gender and relationship between attitudinal variables towards Physics and Additional Mathematics achievement with achievement in Physics. This research focused on six variables, which is attitude towards…

  10. Diode Laser Velocity Measurements by Modulated Filtered Rayleigh Scattering (United States)

    Mach, J. J.; Varghese, P. L.; Jagodzinski, J. J.


    The ability of solid-state lasers to be tuned in operating frequency at MHz rates by input current modulation, while maintaining a relatively narrow line-width, has made them useful for spectroscopic measurements. Their other advantages include low cost, reliability, durability, compact size, and modest power requirements, making them a good choice for a laser source in micro-gravity experiments in drop-towers and in flight. For their size, they are also very bright. In a filtered Rayleigh scattering (FRS) experiment, a diode laser can be used to scan across an atomic or molecular absorption line, generating large changes in transmission at the resonances for very small changes in frequency. The hyperfine structure components of atomic lines of alkali metal vapors are closely spaced and very strong, which makes such atomic filters excellent candidates for sensitive Doppler shift detection and therefore for high-resolution velocimetry. In the work we describe here we use a Rubidium vapor filter, and work with the strong D(sub 2) transitions at 780 nm that are conveniently accessed by near infrared diode lasers. The low power output of infrared laser diodes is their primary drawback relative to other laser systems commonly used for velocimetry. However, the capability to modulate the laser frequency rapidly and continuously helps mitigate this. Using modulation spectroscopy and a heterodyne detection scheme with a lock-in amplifier, one can extract sub-microvolt signals occurring at a specific frequency from a background that is orders of magnitude stronger. The diode laser modulation is simply achieved by adding a small current modulation to the laser bias current. It may also be swept repetitively in wavelength using an additional lower frequency current ramp.

  11. Carrier suppression in quadruple frequency modulation by cascaded optical external modulators for millimeter-wave generation

    Institute of Scientific and Technical Information of China (English)

    Xue Feng; Wei Zhang; Xiaoming Liu


    The optical carrier suppression in optical quadruple frequency modulation by cascaded external modulators is investigated theoretically and experimentally. Theoretical analysis demonstrates that the optical carrier suppression ratio is related with not only the initial phase difference of electrical signals applied on the two modulators, but also the optical phase shift between the two modulators. The maximum suppression ratio can be achieved when the total phase difference is equal to nπ+π/2(n=1,2…),which is verified by experiments. By properly controlling the total phase shift, 40-GHz millimeter-wave is generated by using a 10-GHz radio frequency (RF) source and the modulators.

  12. Stable Optical Phase Modulation with Micromirrors

    CERN Document Server

    Knoernschild, Caleb; Maunz, Peter; Crain, Stephen; Kim, Jungsang


    We measure the motional fluctuations of a micromechanical mirror using a Michelson interferometer, and demonstrate its interferometric stability. The position stability of the micromirror is dominated by the thermal mechanical noise of the structure. With this level of stability, we utilize the micromirror to realize an ideal optical phase modulator by simply reflecting light off the mirror and modulating its position. The resonant frequency of the modulator can be tuned by applying a voltage between the mirror and an underlying electrode. Full modulation depth of +/-\\pi is achieved when the mirror resonantly excited with a sinusoidal voltage at an amplitude of 11V.

  13. Rapid Airplane Parametric Input Design (RAPID) (United States)

    Smith, Robert E.


    RAPID is a methodology and software system to define a class of airplane configurations and directly evaluate surface grids, volume grids, and grid sensitivity on and about the configurations. A distinguishing characteristic which separates RAPID from other airplane surface modellers is that the output grids and grid sensitivity are directly applicable in CFD analysis. A small set of design parameters and grid control parameters govern the process which is incorporated into interactive software for 'real time' visual analysis and into batch software for the application of optimization technology. The computed surface grids and volume grids are suitable for a wide range of Computational Fluid Dynamics (CFD) simulation. The general airplane configuration has wing, fuselage, horizontal tail, and vertical tail components. The double-delta wing and tail components are manifested by solving a fourth order partial differential equation (PDE) subject to Dirichlet and Neumann boundary conditions. The design parameters are incorporated into the boundary conditions and therefore govern the shapes of the surfaces. The PDE solution yields a smooth transition between boundaries. Surface grids suitable for CFD calculation are created by establishing an H-type topology about the configuration and incorporating grid spacing functions in the PDE equation for the lifting components and the fuselage definition equations. User specified grid parameters govern the location and degree of grid concentration. A two-block volume grid about a configuration is calculated using the Control Point Form (CPF) technique. The interactive software, which runs on Silicon Graphics IRIS workstations, allows design parameters to be continuously varied and the resulting surface grid to be observed in real time. The batch software computes both the surface and volume grids and also computes the sensitivity of the output grid with respect to the input design parameters by applying the precompiler tool

  14. Rapidly progressive Alzheimer disease. (United States)

    Schmidt, Christian; Wolff, Martin; Weitz, Michael; Bartlau, Thomas; Korth, Carsten; Zerr, Inga


    Different rates of progression have been observed among patients with Alzheimer disease. Risk factors that accelerate deterioration have been identified and some are being discussed, such as genetics, comorbidity, and the early appearance of Alzheimer disease motor signs. Progressive forms of Alzheimer disease have been reported with rapid cognitive decline and disease duration of only a few years. This short review aims to provide an overview of the current knowledge of rapidly progressive Alzheimer disease. Furthermore, we suggest that rapid, in this context, should be defined as a Mini-Mental State Examination score decrease of 6 points per year.

  15. Modulation of Intercellular Junction by Utilization of Cadherin Peptides as an Effort to Improve Drug Delivery

    Directory of Open Access Journals (Sweden)

    Usman Sumo Friend Tambunan


    Full Text Available Rapid advances in combinatorial chemistry and molecular biology has influenced the discovery of many proteins, peptides and peptidomimetics as potential therapeutic agents. Unfortunately, the practical application of these potential drugs is often restricted by the difficulties of delivering them to target site(s due to the presence of biological barriers. Recently, a new method to improve the drug delivery, that is by modulating the intercellular junction, has been evaluated. Modulation of intercellular junction could be achieved by modulating the proteins which play important role in establishing the intercellular junction, one of which is cadherin. In the present work we have demonstrated the ability of several cadherin peptides, i.e. Ac-LFSHAVSSNG-NH2 (HAV-10, Ac-SHAVSS-NH2 (HAV-6, Ac-QGADTPPVGV-NH2 (ADT-10, and Ac-ADTPPV-NH2 (ADT-6 to modulate the intercellular junction of MDCK (Madin Darby Canine Kidney cells, this finding is a contribution to the establishment of a new method to improve the drug delivery by utilization of cadherin peptides by modulating the intercellular junction.

  16. SAP Sector Develops Rapidly

    Institute of Scientific and Technical Information of China (English)

    Zheng Chengwang


    @@ Stable demand growth internationally Super absorbent polymers (SAP) feature high water absorption, high water retention, rapid water absorption, great expanding power,strong thickening, strong anchoring and excellent elasticity.

  17. Rapid Lead Screening Test (United States)

    ... Vitro Diagnostics Tests Used In Clinical Care Rapid Lead Screening Test Share Tweet Linkedin Pin it More ... reducing the need for a follow-up visit. Lead Risk Links Centers for Disease Control and Prevention ( ...

  18. Hydropower RAPID Toolkit

    Energy Technology Data Exchange (ETDEWEB)


    This fact sheet provides a brief overview of the U.S. Department of Energy (DOE) Hydropower Regulatory and Permitting Information Desktop (RAPID) Toolkit including its capabilities, features, and benefits.

  19. Optimal space communication techniques. [a discussion of delta modulation, pulse code modulation, and phase locked systems (United States)

    Schilling, D. L.


    Encoding of video signals using adaptive delta modulation (DM) was investigated, along with the error correction of DM encoded signals corrupted by thermal noise. Conversion from pulse code modulation to delta modulation was studied; an expression for the signal to noise ratio of the DM signal derived was achieved by employing linear, 2-sample, interpolation between sample points. A phase locked loop using a nonlinear processor in lieu of a loop filter is discussed.

  20. Unstart coupling mechanism analysis of multiple-modules hypersonic inlet. (United States)

    Hu, Jichao; Chang, Juntao; Wang, Lei; Cao, Shibin; Bao, Wen


    The combination of multiplemodules in parallel manner is an important way to achieve the much higher thrust of scramjet engine. For the multiple-modules scramjet engine, when inlet unstarted oscillatory flow appears in a single-module engine due to high backpressure, how to interact with each module by massflow spillage, and whether inlet unstart occurs in other modules are important issues. The unstarted flowfield and coupling characteristic for a three-module hypersonic inlet caused by center module II and side module III were, conducted respectively. The results indicate that the other two hypersonic inlets are forced into unstarted flow when unstarted phenomenon appears on a single-module hypersonic inlet due to high backpressure, and the reversed flow in the isolator dominates the formation, expansion, shrinkage, and disappearance of the vortexes, and thus, it is the major factor of unstart coupling of multiple-modules hypersonic inlet. The coupling effect among multiple modules makes hypersonic inlet be more likely unstarted.

  1. Low modulation bias InGaN-based integrated EA-modulator-laser on semipolar GaN substrate

    KAUST Repository

    Shen, Chao


    In summary, we demonstrated the monolithic integration of electroabsorption modulator with laser diode and measured DC and AC modulation characteristics of the device, which is grown on (2021̅) plane GaN substrate. By alternating the modulation voltage at −3.5 V and 0 V, we achieve the laser output power of < 1.5 mW to > 9 mW, respectively, leading to ∼8.1 dB On/Off ratio. Our results clearly show that a low power consumption modulator can be achieved with semipolar EA-modulator compared to that of the c-plane devices.

  2. Gigascale Silicon Photonic Transmitters Integrating HBT-based Carrier-injection Electroabsorption Modulator Structures (United States)

    Fu, Enjin

    Demand for more bandwidth is rapidly increasing, which is driven by data intensive applications such as high-definition (HD) video streaming, cloud storage, and terascale computing applications. Next-generation high-performance computing systems require power efficient chip-to-chip and intra-chip interconnect yielding densities on the order of 1Tbps/cm2. The performance requirements of such system are the driving force behind the development of silicon integrated optical interconnect, providing a cost-effective solution for fully integrated optical interconnect systems on a single substrate. Compared to conventional electrical interconnect, optical interconnects have several advantages, including frequency independent insertion loss resulting in ultra wide bandwidth and link latency reduction. For high-speed optical transmitter modules, the optical modulator is a key component of the optical I/O channel. This thesis presents a silicon integrated optical transmitter module design based on a novel silicon HBT-based carrier injection electroabsorption modulator (EAM), which has the merits of wide optical bandwidth, high speed, low power, low drive voltage, small footprint, and high modulation efficiency. The structure, mechanism, and fabrication of the modulator structure will be discussed which is followed by the electrical modeling of the post-processed modulator device. The design and realization of a 10Gbps monolithic optical transmitter module integrating the driver circuit architecture and the HBT-based EAM device in a 130nm BiCMOS process is discussed. For high power efficiency, a 6Gbps ultra-low power driver IC implemented in a 130nm BiCMOS process is presented. The driver IC incorporates an integrated 27-1 pseudo-random bit sequence (PRBS) generator for reliable high-speed testing, and a driver circuit featuring digitally-tuned pre-emphasis signal strength. With outstanding drive capability, the driver module can be applied to a wide range of carrier

  3. Mathematics Achievement in High- and Low-Achieving Secondary Schools (United States)

    Mohammadpour, Ebrahim; Shekarchizadeh, Ahmadreza


    This paper identifies the amount of variance in mathematics achievement in high- and low-achieving schools that can be explained by school-level factors, while controlling for student-level factors. The data were obtained from 2679 Iranian eighth graders who participated in the 2007 Trends in International Mathematics and Science Study. Of the…

  4. Modulated Raman Spectroscopy for Enhanced Cancer Diagnosis at the Cellular Level

    Directory of Open Access Journals (Sweden)

    Anna Chiara De Luca


    Full Text Available Raman spectroscopy is emerging as a promising and novel biophotonics tool for non-invasive, real-time diagnosis of tissue and cell abnormalities. However, the presence of a strong fluorescence background is a key issue that can detract from the use of Raman spectroscopy in routine clinical care. The review summarizes the state-of-the-art methods to remove the fluorescence background and explores recent achievements to address this issue obtained with modulated Raman spectroscopy. This innovative approach can be used to extract the Raman spectral component from the fluorescence background and improve the quality of the Raman signal. We describe the potential of modulated Raman spectroscopy as a rapid, inexpensive and accurate clinical tool to detect the presence of bladder cancer cells. Finally, in a broader context, we show how this approach can greatly enhance the sensitivity of integrated Raman spectroscopy and microfluidic systems, opening new prospects for portable higher throughput Raman cell sorting.

  5. Acoustic field modulation in regenerators (United States)

    Hu, J. Y.; Wang, W.; Luo, E. C.; Chen, Y. Y.


    The regenerator is a key component that transfers energy between heat and work. The conversion efficiency is significantly influenced by the acoustic field in the regenerator. Much effort has been spent to quantitatively determine this influence, but few comprehensive experimental verifications have been performed because of difficulties in modulating and measuring the acoustic field. In this paper, a method requiring two compressors is introduced and theoretically investigated that achieves acoustic field modulation in the regenerator. One compressor outputs the acoustic power for the regenerator; the other acts as a phase shifter. A RC load dissipates the acoustic power out of both the regenerator and the latter compressor. The acoustic field can be modulated by adjusting the current in the two compressors and opening the RC load. The acoustic field is measured with pressure sensors instead of flow-field imaging equipment, thereby greatly simplifying the experiment.

  6. Modulation classification based on spectrogram

    Institute of Scientific and Technical Information of China (English)


    The aim of modulation classification (MC) is to identify the modulation type of a communication signal. It plays an important role in many cooperative or noncooperative communication applications. Three spectrogram-based modulation classification methods are proposed. Their reccgnition scope and performance are investigated or evaluated by theoretical analysis and extensive simulation studies. The method taking moment-like features is robust to frequency offset while the other two, which make use of principal component analysis (PCA) with different transformation inputs,can achieve satisfactory accuracy even at low SNR (as low as 2 dB). Due to the properties of spectrogram, the statistical pattern recognition techniques, and the image preprocessing steps, all of our methods are insensitive to unknown phase and frequency offsets, timing errors, and the arriving sequence of symbols.

  7. Digital front-end module (DFEM) series; Digital front end module (DFEM) series

    Energy Technology Data Exchange (ETDEWEB)



    The digital front-end module (DFEM) is a module in which the processes ranging from the reception of digitally modulated radiofrequencies to the output of digital IF (Intermediate Frequency) signals or data streams are integrated. Beginning with a module for the MCNS (Multimedia Cable Network System) cable modem which was the first module in this business field approved by the Cable Labs, U.S., Toshiba has developed a series of DFEMs for various digital media for satellites, ground waves, and CATV (Cable Television) systems. The series is characterized by (1) the serialization of DFEMs compatible with various digital modulation techniques such as 8 PSK (Phase Shift Keying), OFDM (Orthogonal Frequency Division Multiplexing), and 256 QAM (Quadrature Amplitude Modulation), (2) easy connection with digital circuits thanks to the high shielding effect, and (3) the achievement of smaller size, higher performance, and lower power consumption. (translated by NEDO)

  8. Rapid prototyping of reflectors for vehicle lighting using laser activated remote phosphor (United States)

    Lachmayer, Roland; Kloppenburg, Gerolf; Wolf, Alexander


    Bright white light sources are of significant importance for automotive front lighting systems. Today's upper class vehicles mainly use HID or LED as light source. As a further step in this development laser diode based systems offer high luminance, efficiency and allow the realization of new styling concepts and new dynamic lighting functions. These white laser diode systems can either be realized by mixing different spectral sources or by combining diodes with specific phosphors. Based on the approach of generating light using a laser and remote phosphor, lighting modules are manufactured. Four blue laser diodes (450 nm) are used to activate a phosphor coating and thus to achieve white light. A segmented paraboloid reflector generates the desired light distribution for an additional car headlamp. We use high speed milling and selective laser melting to build the reflector system for this lighting module. We compare the spectral reflection grade of these materials. Furthermore the generated modules are analyzed regarding their efficiency and light distribution. The use of Rapid Prototyping technologies allows an early validation of the chosen concept and is supposed to reduce cost and time in the product development process significantly. Therefor we discuss costs and times of the applied manufacturing technologies.

  9. Electrochemically Modulated Separation for Plutonium Safeguards

    Energy Technology Data Exchange (ETDEWEB)

    Pratt, Sandra H.; Breshears, Andrew T.; Arrigo, Leah M.; Schwantes, Jon M.; Duckworth, Douglas C.


    Accurate and timely analysis of plutonium in spent nuclear fuel is critical in nuclear safeguards for detection of both protracted and rapid plutonium diversions. Gamma spectroscopy is a viable method for accurate and timely measurements of plutonium provided that the plutonium is well separated from the interfering fission and activation products present in spent nuclear fuel. Electrochemically modulated separation (EMS) is a method that has been used successfully to isolate picogram amounts of Pu from nitric acid matrices. With EMS, Pu adsorption may be turned "on" and "off" depending on the applied voltage, allowing for collection and stripping of Pu without the addition of chemical reagents. In this work, we have scaled up the EMS process to isolate microgram quantities of Pu from matrices encountered in spent nuclear fuel during reprocessing. Several challenges have been addressed including surface area limitations, radiolysis effects, electrochemical cell performance stability, and chemical interferences. After these challenges were resolved, 6 µg Pu was deposited in the electrochemical cell with approximately an 800-fold reduction of fission and activation product levels from a spent nuclear fuel sample. Modeling showed that these levels of Pu collection and interference reduction may not be sufficient for Pu detection by gamma spectroscopy. The main remaining challenges are to achieve a more complete Pu isolation and to deposit larger quantities of Pu for successful gamma analysis of Pu. If gamma analyses of Pu are successful, EMS will allow for accurate and timely on-site analysis for enhanced Pu safeguards.

  10. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, Themistoklis; Molendijk, John; Timko, Helga; CERN. Geneva. ATS Department


    The LHC RF/LLRF system is currently configured for extremely stable RF voltage to minimize transient beam loading effects. The present scheme cannot be extended beyond nominal beam current since the demanded power would exceed the peak klystron power and lead to saturation. A new scheme has therefore been proposed: for beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test a new algorithm that would adjust the voltage set point to achieve the cavity phase modulation that would minimize klystron forward power.

  11. Peer relationships and academic achievement

    Directory of Open Access Journals (Sweden)

    Krnjajić Stevan B.


    Full Text Available After their childhood, when children begin to establish more intensive social contacts outside family, first of all, in school setting, their behavior i.e. their social, intellectual, moral and emotional development is more strongly affected by their peers. Consequently, the quality of peer relationships considerably affects the process of adaptation and academic achievement and their motivational and emotional attitude towards school respectively. Empirical findings showed that there is bi-directional influence between peer relationships and academic achievement. In other words, the quality of peer relationships affects academic achievement, and conversely, academic achievement affects the quality of peer relationships. For example, socially accepted children exhibiting prosocial, cooperative and responsible forms of behavior in school most frequently have high academic achievement. On the other hand, children rejected by their peers often have lower academic achievement and are a risk group tending to delinquency, absenteeism and drop out of school. Those behavioral and interpersonal forms of competence are frequently more reliable predictors of academic achievement than intellectual abilities are. Considering the fact that various patterns of peer interaction differently exert influence on students' academic behavior, the paper analyzed effects of (a social competence, (b social acceptance/rejection, (c child's friendships and (d prosocial behavior on academic achievement.

  12. Healthy Eating and Academic Achievement

    Centers for Disease Control (CDC) Podcasts


    This podcast highlights the evidence that supports the link between healthy eating and improved academic achievement. It also identifies a few actions to support a healthy school nutrition environment to improve academic achievement.  Created: 12/9/2014 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 12/9/2014.

  13. Physical Activity and Academic Achievement

    Centers for Disease Control (CDC) Podcasts


    This podcast highlights the evidence that supports the link between physical activity and improved academic achievement. It also identifies a few actions to support a comprehensive school physical activity program to improve academic achievement.  Created: 12/9/2014 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 12/9/2014.

  14. Sociocultural Origins of Achievement Motivation (United States)

    Maehr, Martin L.


    Presents a theoretical review of work on sociocultural influences on achievement, focusing on a critical evaluation of the work of David McClellan. Offers an alternative conception of achievement motivation which stresses the role of contextual and situational factors in addition to personality factors. Available from: Transaction Periodicals…

  15. Parental Involvement and Academic Achievement (United States)

    Goodwin, Sarah Christine


    This research study examined the correlation between student achievement and parent's perceptions of their involvement in their child's schooling. Parent participants completed the Parent Involvement Project Parent Questionnaire. Results slightly indicated parents of students with higher level of achievement perceived less demand or invitations…

  16. Super safe small reactor RAPID-L conceptual design and R and D. JAERI's nuclear research promotion program, H11-002 (Contract research)

    Energy Technology Data Exchange (ETDEWEB)

    Kambe, Mitsuru [Central Research Inst. of Electric Power Industry, Tokyo (Japan); Tsunoda, Hirokazu [Mitsubishi Research Inst., Inc., Tokyo (Japan); Mishima, Kaichiro [Kyoto Univ., Kyoto (Japan); Kawasaki, Akira [Tohoku Univ., School of Engineering, Sendai, Miyagi (Japan); Iwamura, Takamichi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment


    The 200 kWe uranium nitride fueled lithium cooled fast reactor 'RAPID-L' combined with thermoelectric power conversion system that can be operated unmanned without refueling for up to ten years has been demonstrated. The RAPID refueling concept enables quick and simplified refueling, and achieves plant design lifetime over 20 years. A significant advantage of the RAPID-L design, which does not require the use of control rods - is the introduction of the innovative reactivity control systems: lithium expansion module (LEM), lithium injection module (LIM) and lithium release module (LRM). LEM is the most promising candidate for improving inherent reactivity feedback. LEMs could realize burnup compensation. LIMs assure sufficient negative reactivity feedback in unprotected transients. LRMs enable an automated reactor startup by detecting the hot standby temperature of the primary coolant. All these systems use {sup 6}Li as liquid poison and are actuated by highly reliable physical properties (volume expansion of {sup 6}Li for LEM, and freeze seal melting for LIM and LRM). (author)

  17. Terrestrial solar modules (United States)

    Sampson, W.; Olah, S.

    Processing methods and materials for the fabrication of solar cell modules are reviewed. It is noted that current production favors copper, particularly in mesh form, as the cell interconnect material due to suitability for stress relief configurations to offset the effects of thermal expansion and deficiencies in the bond between copper and Si. Ethylene vinyl/acetate is preferred to polyvinyl butyral as an encapsulant because it is also a dry film and adheres at low temperature without requiring a pressure bond. The thermal cycling parameters have been set at -40 to 90 C, and tempered low iron, high transmission, water white glass is used as the superstrate. A conceptual design for an automated production of the encapsulated cells is outlined, including the ability to make front and back interconnects and achieve accurate soldering due to the precise location of the solar cells in the process.

  18. Rapid methods : for food and feed quality determination

    NARCIS (Netherlands)

    Amerongen, van A.; Barug, D.; Lauwaars, M.


    There is an ever-increasing need for rapid methods and instrumentation in the field of food and feed quality. Key issues dealt with in the food and feed industry include: monitoring of processes at all stages; showing due diligence in the control of food and nutritional quality; achieving rapid resu

  19. Rapid cooled lens cell (United States)

    Stubbs, David M.; Hsu, Ike C.


    This paper describes the optomechanical design, thermal analysis, fabrication, and test evaluation processes followed in developing a rapid cooled, infrared lens cell. Thermal analysis was the key engineering discipline exercised in the design phase. The effect of thermal stress on the lens, induced by rapid cooling of the lens cell, was investigated. Features of this lens cell that minimized the thermal stress will be discussed in a dedicated section. The results of thermal analysis on the selected lens cell design and the selection of the flow channel design in the heat exchanger will be discussed. Throughout the paper engineering drawings, illustrations, analytical results, and photographs of actual hardware are presented.

  20. Rapid microbiology - raising awareness. (United States)

    Bailie, Jonathan


    A 'high-level overview' of some of the emerging rapid microbiology technologies designed to help healthcare engineering and infection control teams working in hospitals and other healthcare facilities more rapidly identify potentially hazardous levels of waterborne microorganisms in their water systems, enabling them to take prompt remedial action, and a look at the some of the 'pros and cons' of such testing techniques, was given by Nalco technical director, Howard Barnes, the vice-chair of the Legionella Control Association (LCA), at a recent LCA open day. HEJ editor, Jonathan Bailie, reports.

  1. Emissivity modulating electrochromic device (United States)

    Demiryont, Hulya; Shannon, Kenneth C., III; Sheets, Judd


    The IR-ECDTM (Infra-Red ElectroChromic Device) variable emitance device (VED) is an all-solid-state monolithic vacuum deposited thin film system with a unique metamaterial IR transparent-electrode system which functions as an electrically controlled dimmable mirror in the IR region. The maximum reflectance corresponding to the bleached condition of the system is around 90% (low-e condition, e=0.1). The minimum reflectance reaches nearly zero in the colored condition of the system (high emittance, e=1). The average emissivity modulation of the IRECDTM is 0.7 in the 8-12 micron region, and at 9.7 micron (room temperature) it reaches a value of 0.9. Half and full emissivity modulations occur within 2 and10 minutes respectively. Because of its light weight (5g/m2), low voltage requirement (+/- 1 Volts), extremely good emissivity control properties (from 0 to 0.9 at 300K) and highly repeatable deposition process, the IR-ECDTM technology is very attractive for satellite thermal control applications. The IR-ECDTM has been under evaluation in a real space environment since March 8, 2007. This paper presents recent achievements of the IR-ECDTM including space test results.

  2. Module theory, extending modules and generalizations

    CERN Document Server

    Tercan, Adnan


    The main focus of this monograph is to offer a comprehensive presentation of known and new results on various generalizations of CS-modules and CS-rings. Extending (or CS) modules are generalizations of injective (and also semisimple or uniform) modules. While the theory of CS-modules is well documented in monographs and textbooks, results on generalized forms of the CS property as well as dual notions are far less present in the literature. With their work the authors provide a solid background to module theory, accessible to anyone familiar with basic abstract algebra. The focus of the book is on direct sums of CS-modules and classes of modules related to CS-modules, such as relative (injective) ejective modules, (quasi) continuous modules, and lifting modules. In particular, matrix CS-rings are studied and clear proofs of fundamental decomposition results on CS-modules over commutative domains are given, thus complementing existing monographs in this area. Open problems round out the work and establish the...

  3. Cofinitely weak supplemented modules


    Alizade, Rafail; Büyükaşık, Engin


    We prove that a module M is cofinitely weak supplemented or briefly cws (i.e., every submodule N of M with M/N finitely generated, has a weak supplement) if and only if every maximal submodule has a weak supplement. If M is a cws-module then every M-generated module is a cws-module. Every module is cws if and only if the ring is semilocal. We study also modules, whose finitely generated submodules have weak supplements.

  4. On generalized extending modules

    Institute of Scientific and Technical Information of China (English)

    ZENG Qing-yi


    A module M is called generalized extending if for any submodule N of M, there is a direct summand K of M such that N≤K and K/N is singular. Any extending module and any singular module are generalized extending. Any homomorphic image of a generalized extending module is generalized extending. Any direct sum of a singular (uniform) module and a semi-simple module is generalized extending. A ring R is a right Co-H-ring ifand only ifall right R modules are generalized extending modules.

  5. Stereotactic body radiation therapy (SBRT) for adrenal metastases. A feasibility study of advanced techniques with modulated photons and protons

    Energy Technology Data Exchange (ETDEWEB)

    Mancosu, Pietro; Navarria, Piera; Tozzi, Angelo; Castiglioni, Simona; Clerici, Elena; Reggiori, Giacomo; Lobefalo, Francesca [Istituto Clinico Humanitas, Rozzano-Milan (Italy). Dept. of Radiation Oncology; Fogliata, Antonella; Cozzi, Luca [Oncology Institute of Southern Switzerland, Bellinzona (Switzerland). Medical Physics Unit; Scorsetti, Marta


    Purpose: To compare advanced treatment techniques with photons and protons as a stereotactic body radiation therapy (SBRT) for adrenal glands metastases. Materials and Methods: Planning computer tomographic (CT) scans of 10 patients were selected. A total dose of 45 Gy in 7.5 Gy fractions was prescribed. Organs at risk (OAR) were liver and kidneys. Dose-volume metrics were defined to quantify quality of plans assessing target coverage and sparing of organs at risk. Plans for RapidArc, intensity-modulated radiotherapy (IMRT), dynamic conformal arcs, 3D conformal static fields, and intensity modulated protons were compared. The main planning objective for the clinical target volume (CTV) was to cover 100% of the volume with 95% (V{sub 95%} = 100%) and to keep the maximum dose below 107% of the prescribed dose (V{sub 107%} = 0%). Planning objective for planning target volume (PTV) was V{sub 95%} > 80%. For kidneys, the general planning objective was V{sub 15Gy} < 35% and for liver V{sub 15Gy} < (liver volume-700 cm{sup 3}). Results: All techniques achieved the minimum and maximum dose objective for CTV and PTV, D{sub 5-95%} ranged from 1 Gy (protons) to 1.6 Gy (conformal static fields) on CTV. Maximal organ at risk sparing was achieved by protons. RapidArc presented the second lowest dose bath (V{sub 10Gy} and integral dose) after protons and the best conformality together with IMRT. Conclusions: Stereotactic body radiation therapy (SBRT) to adrenal glands metastases is achievable with several advanced techniques with either photons or protons. The intensity modulated approaches using either static fields, dynamic arcs or protons are superior to the other conformal solutions. For their simplicity, IMRT or RapidArc should be considered as the first option radiation treatment for those patients not eligible for proton treatment. (orig.)

  6. ITER Central Solenoid Module Fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Smith, John [General Atomics, San Diego, CA (United States)


    The fabrication of the modules for the ITER Central Solenoid (CS) has started in a dedicated production facility located in Poway, California, USA. The necessary tools have been designed, built, installed, and tested in the facility to enable the start of production. The current schedule has first module fabrication completed in 2017, followed by testing and subsequent shipment to ITER. The Central Solenoid is a key component of the ITER tokamak providing the inductive voltage to initiate and sustain the plasma current and to position and shape the plasma. The design of the CS has been a collaborative effort between the US ITER Project Office (US ITER), the international ITER Organization (IO) and General Atomics (GA). GA’s responsibility includes: completing the fabrication design, developing and qualifying the fabrication processes and tools, and then completing the fabrication of the seven 110 tonne CS modules. The modules will be shipped separately to the ITER site, and then stacked and aligned in the Assembly Hall prior to insertion in the core of the ITER tokamak. A dedicated facility in Poway, California, USA has been established by GA to complete the fabrication of the seven modules. Infrastructure improvements included thick reinforced concrete floors, a diesel generator for backup power, along with, cranes for moving the tooling within the facility. The fabrication process for a single module requires approximately 22 months followed by five months of testing, which includes preliminary electrical testing followed by high current (48.5 kA) tests at 4.7K. The production of the seven modules is completed in a parallel fashion through ten process stations. The process stations have been designed and built with most stations having completed testing and qualification for carrying out the required fabrication processes. The final qualification step for each process station is achieved by the successful production of a prototype coil. Fabrication of the first

  7. Ballasted photovoltaic module and module arrays (United States)

    Botkin, Jonathan; Graves, Simon; Danning, Matt


    A photovoltaic (PV) module assembly including a PV module and a ballast tray. The PV module includes a PV device and a frame. A PV laminate is assembled to the frame, and the frame includes an arm. The ballast tray is adapted for containing ballast and is removably associated with the PV module in a ballasting state where the tray is vertically under the PV laminate and vertically over the arm to impede overt displacement of the PV module. The PV module assembly can be installed to a flat commercial rooftop, with the PV module and the ballast tray both resting upon the rooftop. In some embodiments, the ballasting state includes corresponding surfaces of the arm and the tray being spaced from one another under normal (low or no wind) conditions, such that the frame is not continuously subjected to a weight of the tray.

  8. Synchronization of chaotic VCSELs by external chaotic signal parameter modulation

    Institute of Scientific and Technical Information of China (English)

    Wei Wang; Shenghai Zhang; Xingzhong Qian; Yanbin Wang


    Synchronization of chaotic vertical-cavity surface-emitting lasers (VCSELs) is achieved by external chaotic signal modulation successfully.Simulation indicates that we can get chaos synchronization if the intensity of external chaotic signal is large enough.First of all,we use direct current modulation to achieve the chaos of VCSELs,and determine the laser's chaotic state by analyzing time series of the output and the corresponding power spectrum.And then we achieve synchronization of the two chaotic systems by external chaotic signal parameter modulation.We also find that the larger the modulation intensity is,the easier it is to achieve synchronization for chaotic VCSELs.This approach can also be applied to systems with a number of modulated lasers.

  9. Surgically assisted rapid maxillary expansion in adults. (United States)

    Pogrel, M A; Kaban, L B; Vargervik, K; Baumrind, S


    Twelve adults with maxillary width discrepancy of greater than 5 mm were treated by surgically assisted rapid maxillary expansion. The procedure consisted of bilateral zygomatic buttress and midpalatal osteotomies combined with the use of a tooth-borne orthopedic device postoperatively. Mean palatal expansion of 7.5 mm (range of 6 to 13 mm), measured in the first molar region, was achieved within 3 weeks in all patients. Expansion remained stable during the 12-month study period, with a mean relapse for the entire group of 0.88 +/- 0.48 mm. Morbidity was limited to mild postoperative discomfort. The results of this preliminary study indicated that surgically assisted rapid maxillary expansion is a safe, simple, and reliable procedure for achieving a permanent increase in skeletal maxillary width in adults. Further study is necessary to document the three-dimensional movements of the maxillary segments and long-term stability of the skeletal and dental changes.

  10. Kranc: Cactus modules from Mathematica equations (United States)

    Husa, Sascha; Hinder, Ian; Lechner, Christiane; Schnetter, Erik; Wardell, Barry


    Kranc turns a tensorial description of a time dependent partial differential equation into a module for the Cactus Computational Toolkit (ascl:1102.013). This Mathematica application takes a simple continuum description of a problem and generates highly efficient and portable code, and can be used both for rapid prototyping of evolution systems and for high performance supercomputing.

  11. Wreathes of Magnetism in Rapidly Rotating Suns

    CERN Document Server

    Brown, Benjamin P; Brun, Allan Sacha; Toomre, Juri


    When our Sun was young it rotated much more rapidly than now. Observations of young, rapidly rotating stars indicate that many possess substantial magnetic activity and strong axisymmetric magnetic fields. We conduct simulations of dynamo action in rapidly rotating suns with the 3-D MHD anelastic spherical harmonic (ASH) code to explore the complex coupling between rotation, convection and magnetism. Here we study dynamo action realized in the bulk of the convection zone for two systems, rotating at three and five times the current solar rate. We find that substantial organized global-scale magnetic fields are achieved by dynamo action in these systems. Striking wreathes of magnetism are built in the midst of the convection zone, coexisting with the turbulent convection. This is a great surprise, for many solar dynamo theories have suggested that a tachocline of penetration and shear at the base of the convection zone is a crucial ingredient for organized dynamo action, whereas these simulations do not includ...

  12. Rapid Hepatitis B Vaccination in Adults

    Directory of Open Access Journals (Sweden)

    Mansur Özcan


    Full Text Available Vaccination is a very important method in prevention of HBV.Especially rapid immunization takes an important place in subjects at highrisk. We have injected HBV vaccine to health workers who are attending inour hospital by rapid immunisation programme (at 0, 1 and 2 months andaimed to identify it’s efficiacy. Eighty seven subjects (69% male, 31%female were included to our study. Median age was 34 for male and 32 forwomen. We obtained 90% achievement of immunity rate after theprogramme finished. There were no significant difference between maleend female groups, and age groups. The non-responder rate was 11.6% inmale, and 7.4% in female. This rate was 6% in under 40 years old group,and 22.7% in 40 or older group. This difference was significant in twogroups statistically (p=0.02. The rapid immunization programme, weperformed has nearly the same success results as in standard programme.

  13. Using structure to inform carbohydrate binding module function

    NARCIS (Netherlands)

    Abbott, D. Wade; Lammerts van Bueren, Alicia


    Generally, non-catalytic carbohydrate binding module (CBM) specificity has been shown to parallel the catalytic activity of the carbohydrate active enzyme (CAZyme) module it is appended to. With the rapid expansion in metagenomic sequence space for the potential discovery of new CBMs in addition to

  14. Transient heliosheath modulation (United States)

    Quenby, J. J.; Webber, W. R.


    Voyager 1 has explored the solar wind-interstellar medium interaction region between the terminal shock and heliopause, following the intensity distribution of Galactic cosmic ray protons above 200 MeV energy. Before this component reached the expected galactic flux level at 121.7 au from the Sun, four episodes of rapid intensity change occurred with a behaviour similar to that found in Forbush Decreases in the inner Solar system, rather than that expected from a mechanism related to models for the long-term modulation found closer to the Sun. Because the mean solar wind flow is both expected and observed to be perpendicular to the radial direction close to the heliopause, an explanation is suggested in terms of transient radial flows related to possible heliopause boundary flapping. It is necessary that the radial flows are of the order either of the sound speed found for conditions downstream of the terminal shock or of the fluctuations found near the boundary by the Voyager 1 Low Energy Charged Particle detector and that the relevant cosmic ray diffusion perpendicular to the mean field is controlled by `slab' fluctuations accounting for about 20 per cent of the total power in the field variance. However, additional radial drift motion related to possible north to south gradients in the magnetic field may allow the inclusion of some diffusion according to the predictions of a theory based upon the presence of 2D turbulence. The required field gradients may arise due to field variation in the field carried by solar plasma flow deflected away from the solar equatorial plane. Modulation amounting to a total 30 per cent drop in galactic intensity requires explanation by a combination of transient effects.

  15. Rapid-Sequence Intubation

    Directory of Open Access Journals (Sweden)

    Evangelina Dávila Cabo de Villa


    Full Text Available In medical practice there are several situations that require immediate intervention of the airway in some patients, in order to ensure proper entrance and exit of gases into and out of the lungs and prevent aspiration. Rapid-sequence intubation has been considered as the administration of a hypnotic agent and a neuromuscular relaxant consecutively (virtually simultaneously to facilitate orotracheal intubation in critically ill patients and minimize the risk of aspiration. This paper aims to collect elements that promote a successful medical management according to the situation presented, since there is no single way of proceeding in case of rapid-sequence intubation. The elements to consider include: knowing the anatomy of the upper respiratory tract, having a group of drugs to choose from, receiving adequate training and having an alternative plan for the difficulties that may arise.

  16. MI 4010 Thermoelectric Modules. (United States)

    The report covers the design justification, physical specification and characterization of the MI 4010 module . The purpose of the contract was to...demonstrate the capability to fabricate pieceparts, process into assemblies, and test thermoelectric modules equivalent to the module used in the Hand...Held Thermal Viewer. The completed modules were also subjected to limited demonstration tests of reliability and useful life.

  17. Module utilization committee (United States)

    Volkmer, K.; Praver, G.


    Photovoltaic collector modules were declared surplus to the needs of the U.S. Dept. of Energy. The Module Utilization Committee was formed to make appropriate disposition of the surplus modules on a national basis and to act as a broker for requests for these modules originating outside of the National Photovoltaics Program.

  18. Rapid Detection of Pathogens

    Energy Technology Data Exchange (ETDEWEB)

    David Perlin


    Pathogen identification is a crucial first defense against bioterrorism. A major emphasis of our national biodefense strategy is to establish fast, accurate and sensitive assays for diagnosis of infectious diseases agents. Such assays will ensure early and appropriate treatment of infected patients. Rapid diagnostics can also support infection control measures, which monitor and limit the spread of infectious diseases agents. Many select agents are highly transmissible in the early stages of disease, and it is critical to identify infected patients and limit the risk to the remainder of the population and to stem potential panic in the general population. Nucleic acid-based molecular approaches for identification overcome many of the deficiencies associated with conventional culture methods by exploiting both large- and small-scale genomic differences between organisms. PCR-based amplification of highly conserved ribosomal RNA (rRNA) genes, intergenic sequences, and specific toxin genes is currently the most reliable approach for bacterial, fungal and many viral pathogenic agents. When combined with fluorescence-based oligonucleotide detection systems, this approach provides real-time, quantitative, high fidelity analysis capable of single nucleotide allelic discrimination (4). These probe systems offer rapid turn around time (<2 h) and are suitable for high throughput, automated multiplex operations that are critical for clinical diagnostic laboratories. In this pilot program, we have used molecular beacon technology invented at the Public health Research Institute to develop a new generation of molecular probes to rapidly detect important agents of infectious diseases. We have also developed protocols to rapidly extract nucleic acids from a variety of clinical specimen including and blood and tissue to for detection in the molecular assays. This work represented a cooperative research development program between the Kramer-Tyagi/Perlin labs on probe development

  19. New Rapid Spore Assay (United States)

    Kminek, Gerhard; Conley, Catharine


    The presentation will detail approved Planetary Protection specifications for the Rapid Spore Assay for spacecraft components and subsystems. Outlined will be the research and studies on which the specifications were based. The research, funded by ESA and NASA/JPL, was conducted over a period of two years and was followed by limited cleanroom studies to assess the feasibility of this assay during spacecraft assembly.

  20. Tiber Personal Rapid Transit

    Directory of Open Access Journals (Sweden)

    Diego Carlo D'agostino


    Full Text Available The project “Tiber Personal Rapid Transit” have been presented by the author at the Rome City Vision Competition1 2010, an ideas competition, which challenges architects, engineers, designers, students and creatives individuals to develop visionary urban proposals with the intention of stimulating and supporting the contemporary city, in this case Rome. The Tiber PRT proposal tries to answer the competition questions with the definition of a provocative idea: a Personal Rapid transit System on the Tiber river banks. The project is located in the central section of the Tiber river and aims at the renewal of the river banks with the insertion of a Personal Rapid Transit infrastructure. The project area include the riverbank of Tiber from Rome Transtevere RFI station to Piazza del Popolo, an area where main touristic and leisure attractions are located. The intervention area is actually no used by the city users and residents and constitute itself a strong barrier in the heart of the historic city.

  1. Energy-efficient WDM-OFDM-PON employing shared OFDM modulation modules in optical line terminal. (United States)

    Hu, Xiaofeng; Zhang, Liang; Cao, Pan; Wang, Kongtao; Su, Yikai


    We propose and experimentally demonstrate a scheme to improve the energy efficiency of wavelength division multiplexing - orthogonal frequency division multiplexing - passive optical networks (WDM-OFDM-PONs). By using an N × M opto-mechanic switch in optical line terminal (OLT), an OFDM modulation module is shared by several channels to deliver data to multiple users with low traffic demands during non-peak hours of the day, thus greatly reducing the number of operating devices and minimizing the energy consumption of the OLT. An experiment utilizing one OFDM modulation module to serve three optical network units (ONUs) in a WDM-OFDM-PON is performed to verify the feasibility of our proposal. Theoretical analysis and numerical calculation show that the proposed scheme can achieve a saving of 23.6% in the energy consumption of the OFDM modulation modules compared to conventional WDM-OFDM-PON.

  2. A Novel Electro-Optic Polymer Modulator Based on Long Period Fiber Gratings

    Institute of Scientific and Technical Information of China (English)

    Xiaowei Dong; Li Pei; Bin Li; Shui-sheng Jian


    A novel high-speed electro-optic (EO) polymer modulator based on long period gratings (LPG) is designed. Using the theory of multi-cladding optical waveguide, we achieved relationship between modulate voltage and LPG’s resonant wavelength.

  3. A Novel Electro-Optic Polymer Modulator Based on Long Period Fiber Gratings

    Institute of Scientific and Technical Information of China (English)


    A novel high-speed electro-optic (EO) polymer modulator based on long period gratings (LPG) is designed. Using the theory of multi-cladding optical waveguide, we achieved relationship between modulate voltage and LPG's resonant wavelength.

  4. Disciplinary climate and student achievement

    DEFF Research Database (Denmark)

    Sortkær, Bent; Reimer, David

    Disciplinary climate has emerged as one of the single most important factors related to student achievement. Using data from the OECD Programme for International Student Assessment (PISA) 2003 for Canada, Denmark, Finland, Iceland, Latvia and Norway we find a significant and nontrivial association...... between the perceived disciplinary climate in the classroom and students’ mathematics performance in Canada, Denmark and Norway. Furthermore we exploit country specific class-size rules in order to single out a subsample with classroom-level data (PISA is sampled by age and not by classes) and find...... that the estimates based on school-level data might underestimate the relationship between disciplinary climate and student achievement. Finally we find evidence for gender differences in the association between disciplinary climate and student achievement that can partly be explained by gender-specific perceptions...

  5. Mathematics Achievement by Immigrant Children

    Directory of Open Access Journals (Sweden)

    Gary G. Huang


    Full Text Available In this study, I examined academic achievement of immigrant children in the United States, Canada, England, Australia, and New Zealand. Analyzing data from the Third International Mathematics and Science Study (TIMSS, I gauged the performance gaps relating to the generation of immigration and the home language background. I found immigrant children's math and science achievement to be lower than the others only in England, the U.S., and Canada. Non-English language background was found in each country to relate to poor math and science learning and this disadvantage was stronger among native-born children—presumably children of indigenous groups—than among immigrant children. I also examined the school variation in math performance gaps, using hierarchical linear modeling (HLM to each country's data. The patterns in which language- and generation-related math achievement gaps varied between schools are different in the five countries.

  6. Foreign language comprehension achievement: insights from the cognate facilitation effect


    Casaponsa, Aina; Antón, Eneko; Pérez, Alejandro; Duñabeitia, Jon A.


    Numerous studies have shown that the native language influences foreign word recognition and that this influence is modulated by the proficiency in the non-native language. Here we explored how the degree of reliance on cross-language similarity (as measured by the cognate facilitation effect) together with other domain-general cognitive factors contribute to reading comprehension achievement in a non-native language at different stages of the learning process. We tested two groups of native ...

  7. Coherent Detection of Wavelength Division Multiplexed Phase-Modulated Radio-over-Fibre Signals

    DEFF Research Database (Denmark)

    Zibar, Darko; Yu, Xianbin; Peucheret, Christophe


    A WDM phase-modulated Radio-over-Fibre link using digital coherent detection is experimentally demonstrated. 3 times 50 Mb/s WDM transmission of a BPSK modulated 5 GHz RF carrier is achieved over 25 km.......A WDM phase-modulated Radio-over-Fibre link using digital coherent detection is experimentally demonstrated. 3 times 50 Mb/s WDM transmission of a BPSK modulated 5 GHz RF carrier is achieved over 25 km....

  8. Hemispherical power asymmetry from scale-dependent modulated reheating

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, John, E-mail: [Lancaster-Manchester-Sheffield Consortium for Fundamental Physics, Cosmology and Astroparticle Physics Group, Dept. of Physics, University of Lancaster, Lancaster LA1 4YB (United Kingdom)


    We propose a new model for the hemispherical power asymmetry of the CMB based on modulated reheating. Non-Gaussianity from modulated reheating can be small enough to satisfy the bound from Planck if the dominant modulation of the inflaton decay rate is linear in the modulating field σ. σ must then acquire a spatially-modulated power spectrum with a red scale-dependence. This can be achieved if the primordial perturbation of σ is generated via tachyonic growth of a complex scalar field. Modulated reheating due to σ then produces a spatially modulated and scale-dependent sub-dominant contribution to the adiabatic density perturbation. We show that it is possible to account for the observed asymmetry while remaining consistent with bounds from quasar number counts, non-Gaussianity and the CMB temperature quadupole. The model predicts that the adiabatic perturbation spectral index and its running will be modified by the modulated reheating component.

  9. Right-Rapid-Rough (United States)

    Lawrence, Craig


    IDEO (pronounced 'eye-dee-oh') is an international design, engineering, and innovation firm that has developed thousands of products and services for clients across a wide range of industries. Its process and culture attracted the attention of academics, businesses, and journalists around the world, and are the subject of a bestselling book, The Art of Innovation by Tom Kelley. One of the keys to IDEO's success is its use of prototyping as a tool for rapid innovation. This story covers some of IDEO's projects, and gives reasons for why they were successful.

  10. Rapid prototype and test

    Energy Technology Data Exchange (ETDEWEB)

    Gregory, D.L.; Hansche, B.D.


    In order to support advanced manufacturing, Sandia has acquired the capability to produce plastic prototypes using stereolithography. Currently, these prototypes are used mainly to verify part geometry and ``fit and form`` checks. This project investigates methods for rapidly testing these plastic prototypes, and inferring from prototype test data actual metal part performance and behavior. Performances examined include static load/stress response, and structural dynamic (modal) and vibration behavior. The integration of advanced non-contacting measurement techniques including scanning laser velocimetry, laser holography, and thermoelasticity into testing of these prototypes is described. Photoelastic properties of the epoxy prototypes to reveal full field stress/strain fields are also explored.

  11. Rapidly progressive tabetic neurosyphilis

    Institute of Scientific and Technical Information of China (English)

    赖伟红; 薛华忠; 韩国柱


    Since the sexually transmitted diseases were recognized as a public health problem in China during the early 1980's, the incidence of syphilis has gradually increased. Though there have been case reports of clinical variants of neurosyphilis, including syphilitic cerebrospinal meningitis or meningomyelitis and meningovascular syphilis, occurring in different regions of China,1-3 tabes dorsalis or tabetic neurosyphilis has not yet been reported in China. Here, we report a young man with rapidly progressive tabetic neurosyphilis admitted to our hospital in October 1999.

  12. FFAGS for rapid acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Carol J. Johnstone and Shane Koscielniak


    When large transverse and longitudinal emittances are to be transported through a circular machine, extremely rapid acceleration holds the advantage that the beam becomes immune to nonlinear resonances because there is insufficient time for amplitudes to build up. Uncooled muon beams exhibit large emittances and require fast acceleration to avoid decay losses and would benefit from this style of acceleration. The approach here employs a fixed-field alternating gradient or FFAG magnet structure and a fixed frequency acceleration system. Acceptance is enhanced by the use only of linear lattice elements, and fixed-frequency rf enables the use of cavities with large shunt resistance and quality factor.


    Institute of Scientific and Technical Information of China (English)


    Povas esti tre malpla■e en urbegoj, se estas du lokoj, kie flugma■ino povas alteri■i, kaj oni devas rapi-de transiri de unu al la alia. Tiel estas ekzemple en Parizo. Foje mi alteri■is en Charles-de-Gaulle[elparolu■arl de gol’], kaj devis reekflugi el Orly[orli’]. Mi havis malmulte da tempo inter la alveno en unu kaj laflugo el la alia. Kaj jen la personaro, kiu funkciigas la publikajn transportojn, tiutage ne ofieis, ■ar la ■tatomalkonsentis altigi ■ian laborpagon. La urbo estis tiom plena je veturiloj, ke estis preskaǔneeble

  14. Epistemological Beliefs and Academic Achievement (United States)

    Arslantas, Halis Adnan


    This study aimed to identify the relationship between teacher candidates' epistemological beliefs and academic achievement. The participants of the study were 353 teacher candidates studying their fourth year at the Education Faculty. The Epistemological Belief Scale was used which adapted to Turkish through reliability and validity work by…

  15. Adolescents' Academic Expectations and Achievement. (United States)

    Sanders, Christopher E.; Field, Tiffany M.; Diego, Miguel A.


    Hypothesis that mother relationships are more influential than father relationships on adolescents' academic expectations and achievement was tested with 80 high school seniors. The mother child relationship was found to be predictive of academic expectations. It suggests that the amount of time they spend together may be the contributing factor.…

  16. The opening of achievement report

    Institute of Scientific and Technical Information of China (English)


    The unified plan for Sharqu River has been worked out by experts from Yangtze Water Conservancy Commission, Yangtze Hydraulic Engineering Investigation Academy, and the Academy from T.A.R. A meeting of reporting their achievements has been hold in Lhasa.

  17. Chinese Achievements Attract Worldwide Attention

    Institute of Scientific and Technical Information of China (English)


    THE People’s Republic of China was founded 45 years ago. Since the policies of economic and social reform and opening were carried out in the beginning of the 1980s, China has been gradually entering into prosperity and has made inspiring achievements. 1. The living standards of the people and their

  18. Achieving universal access to broadband

    DEFF Research Database (Denmark)

    Falch, Morten; Henten, Anders


    The paper discusses appropriate policy measures for achieving universal access to broadband services in Europe. Access can be delivered by means of many different technology solutions described in the paper. This means a greater degree of competition and affects the kind of policy measures...

  19. Achieving a sustainable service advantage. (United States)

    Coyne, K P


    Many managers believe that superior service should play little or no role in competitive strategy; they maintain that service innovations are inherently copiable. However, the author states that this view is too narrow. For a company to achieve a lasting service advantage, it must base a new service on a capability gap that competitors cannot or will not copy.

  20. Achieving world class maintenance status

    Energy Technology Data Exchange (ETDEWEB)

    Tomlingson, P.D. [Paul D. Tomingson Associates (United States)


    The article written by a management consultant, discusses the art of successful planning and operation of maintenance in mines considering factors such as benchmaking, key performance indices (KPIs) and frequency of procedures which can help achieve 'world class maintenance'. 1 fig.

  1. Faculty Development: Assessing Learner Achievement. (United States)

    Frey, Barbara A.; Overfield, Karen

    This study addressed the challenges of developing a faculty professional development workshop on assessment, measurement, and evaluation of achievement in adult learners. The setting for the workshop was a system of postsecondary career colleges throughout the United States. The curriculum development model of D. Kirkpatrick (1994) was used as a…

  2. Modulation Techniques for Li-Fi

    Institute of Scientific and Technical Information of China (English)

    Mohamed Sufyan Islim; Harald Haas


    Modulation techniques for light fidelity (Li⁃Fi) are reviewed in this paper. Li⁃Fi is the fully networked solution for multiple users that combines communication and illumination simultaneously. Light emitting diodes (LEDs) are used in Li⁃Fi as visible light transmitters, therefore, only intensity modulated direct detected modulation techniques can be achieved. Single carrier modulation techniques are straightforward to be used in Li⁃Fi, however, computationally complex equalization processes are required in fre⁃quency selective Li⁃Fi channels. On the other hand, multicarrier modulation techniques offer a viable solution for Li⁃Fi in terms of power, spectral and computational efficiency. In particular, orthogonal frequency division multiplexing (OFDM) based modula⁃tion techniques offer a practical solution for Li⁃Fi, especially when direct current (DC) wander, and adaptive bit and power load⁃ing techniques are considered. Li⁃Fi modulation techniques need to also satisfy illumination requirements. Flickering avoidance and dimming control are considered in the variant modulation techniques presented. This paper surveys the suitable modulation techniques for Li⁃Fi including those which explore time, frequency and colour domains.

  3. The Rapid Transient Surveyor

    CERN Document Server

    Baranec, Christoph; Wright, Shelley A; Tonry, John; Tully, R Brent; Szapudi, István; Takamiya, Marianne; Hunter, Lisa; Riddle, Reed; Chen, Shaojie; Chun, Mark


    The Rapid Transient Surveyor (RTS) is a proposed rapid-response, high-cadence adaptive optics (AO) facility for the UH 2.2-m telescope on Maunakea. RTS will uniquely address the need for high-acuity and sensitive near-infrared spectral follow-up observations of tens of thousands of objects in mere months by combining an excellent observing site, unmatched robotic observational efficiency, and an AO system that significantly increases both sensitivity and spatial resolving power. We will initially use RTS to obtain the infrared spectra of ~4,000 Type Ia supernovae identified by the Asteroid Terrestrial-Impact Last Alert System over a two year period that will be crucial to precisely measuring distances and mapping the distribution of dark matter in the z < 0.1 universe. RTS will comprise an upgraded version of the Robo-AO laser AO system and will respond quickly to target-of-opportunity events, minimizing the time between discovery and characterization. RTS will acquire simultaneous-multicolor images with a...

  4. The rapid transient surveyor (United States)

    Baranec, C.; Lu, J. R.; Wright, S. A.; Tonry, J.; Tully, R. B.; Szapudi, I.; Takamiya, M.; Hunter, L.; Riddle, R.; Chen, S.; Chun, M.


    The Rapid Transient Surveyor (RTS) is a proposed rapid-response, high-cadence adaptive optics (AO) facility for the UH 2.2-m telescope on Maunakea. RTS will uniquely address the need for high-acuity and sensitive near-infrared spectral follow-up observations of tens of thousands of objects in mere months by combining an excellent observing site, unmatched robotic observational efficiency, and an AO system that significantly increases both sensitivity and spatial resolving power. We will initially use RTS to obtain the infrared spectra of 4,000 Type Ia supernovae identified by the Asteroid Terrestrial-Impact Last Alert System over a two year period that will be crucial to precisely measuring distances and mapping the distribution of dark matter in the z efficiency prism integral field unit spectrograph: R = 70-140 over a total bandpass of 840-1830nm with an 8.7" by 6.0" field of view (0.15" spaxels). The AO correction boosts the infrared point-source sensitivity of the spectrograph against the sky background by a factor of seven for faint targets, giving the UH 2.2-m the H-band sensitivity of a 5.7-m telescope without AO.

  5. Host modulation by therapeutic agents

    Directory of Open Access Journals (Sweden)

    Sugumari Elavarasu


    Full Text Available Periodontal disease susceptible group present advanced periodontal breakdown even though they achieve a high standard of oral hygiene. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at bringing these enzymes and mediators to normal level. Doxycycline, nonsteroidal anti-inflammatory drugs (NSAIDs, bisphosphonates, nitrous oxide (NO synthase inhibitors, recombinant human interleukin-11 (rhIL-11, omega-3 fatty acid, mouse anti-human interleukin-6 receptor antibody (MRA, mitogen-activated protein kinase (MAPK inhibitors, nuclear factor-kappa B (NF-kb inhibitors, osteoprotegerin, and tumor necrosis factor antagonist (TNF-α are some of the therapeutic agents that have host modulation properties.

  6. Compressed Encoding for Rank Modulation

    CERN Document Server

    Gad, Eyal En; Jiang,; Bruck, Jehoshua


    Rank modulation has been recently proposed as a scheme for storing information in flash memories. While rank modulation has advantages in improving write speed and endurance, the current encoding approach is based on the "push to the top" operation that is not efficient in the general case. We propose a new encoding procedure where a cell level is raised to be higher than the minimal necessary subset - instead of all - of the other cell levels. This new procedure leads to a significantly more compressed (lower charge levels) encoding. We derive an upper bound for a family of codes that utilize the proposed encoding procedure, and consider code constructions that achieve that bound for several special cases.

  7. Academic resilience in education: the role of achievement goal orientations

    Directory of Open Access Journals (Sweden)



    Full Text Available Introduction: In the past 2 decades, research findings established achievement goal theory as a powerful framework for conceptualizing difference in the quality of student’s engagement, persistence on task, and academic resilience. So the present study examined the relationship between achievement goal orientations and academic resilience. Method: Participants were 606 students (307 girls and 297 boys selected from Shiraz high schools. They completed the Achievement Goals Questionnaire and Youth development Module Scale (RYDM. To analyze the data, the relationships between variables were examined, using Pearson product– moment correlations. Also simulanteous multiple regression was performed to investigate the prediction of academic resilience by achievement goal orientations. To examine the reliability and the validity of measures Cronbach alpha coefficient and factor analysis method were applied, respectively. Results: Simultaneous multiple regression of achievement goal orientations on academic resilience showed that “mastery-approach” was a significant positive predictor of the “home care/high” and “peer care” subscales. Also, “performance-approach” was a significant, positive predictor of “home care/ high”, and “school/community meaningful” was predicted by “performanceavoidance” positively. Conclusion: According to the findings, it seems that achievement goal orientation has a critical role in students’ academic achievement. Implications of the results are discussed in more details.

  8. Metacognition, achievement goals, study strategies and academic achievement: pathways to achievement

    NARCIS (Netherlands)

    Vrugt, A.; Oort, F.J.


    The purpose of this research was to develop and test a model of effective selfregulated learning. Based on effort expenditure we discerned effective self-regulators and less effective self-regulators. The model comprised achievement goals (mastery, performance-approach and -avoidance goals), metacog

  9. Metacognition, Achievement Goals, Study Strategies and Academic Achievement: Pathways to Achievement (United States)

    Vrugt, Anneke; Oort, Frans J.


    The purpose of this research was to develop and test a model of effective self-regulated learning. Based on effort expenditure we discerned effective self-regulators and less effective self-regulators. The model comprised achievement goals (mastery, performance-approach and -avoidance goals), metacognition (metacognitive knowledge, regulation and…

  10. Earth System Science Education Modules (United States)

    Hall, C.; Kaufman, C.; Humphreys, R. R.; Colgan, M. W.


    The College of Charleston is developing several new geoscience-based education modules for integration into the Earth System Science Education Alliance (ESSEA). These three new modules provide opportunities for science and pre-service education students to participate in inquiry-based, data-driven experiences. The three new modules will be discussed in this session. Coastal Crisis is a module that analyzes rapidly changing coastlines and uses technology - remotely sensed data and geographic information systems (GIS) to delineate, understand and monitor changes in coastal environments. The beaches near Charleston, SC are undergoing erosion and therefore are used as examples of rapidly changing coastlines. Students will use real data from NASA, NOAA and other federal agencies in the classroom to study coastal change. Through this case study, learners will acquire remotely sensed images and GIS data sets from online sources, utilize those data sets within Google Earth or other visualization programs, and understand what the data is telling them. Analyzing the data will allow learners to contemplate and make predictions on the impact associated with changing environmental conditions, within the context of a coastal setting. To Drill or Not To Drill is a multidisciplinary problem based module to increase students’ knowledge of problems associated with nonrenewable resource extraction. The controversial topic of drilling in the Arctic National Wildlife Refuge (ANWR) examines whether the economic benefit of the oil extracted from ANWR is worth the social cost of the environmental damage that such extraction may inflict. By attempting to answer this question, learners must balance the interests of preservation with the economic need for oil. The learners are exposed to the difficulties associated with a real world problem that requires trade-off between environmental trust and economic well-being. The Citizen Science module challenges students to translate scientific

  11. The incongruous achiever in adolescence. (United States)

    Kline, S A; Golombek, H


    The authors wished to study some of the internal psychological dynamics of achievement in a nonpatient identified high school population. Questionnaires were administered to the Grade 13 students and their parents in a large high school. A number of students whose achievement and educational plans were not congruous with their general background were selected for interview. The findings suggest that a wide variety of ages and developmental stages can be discerned as critical points in the development of a student's attitude toward higher education. These students have many values in common, and their values appear related to a positive or negative identification with parental values. The students themselves show a wide range of personality integration. They relate in a special way to a wide variety of teachers' personalities.

  12. Database Research: Achievements and Challenges

    Institute of Scientific and Technical Information of China (English)

    Shan Wang; Xiao-Yong Du; Xiao-Feng Meng; Hong Chen


    Database system is the infrastructure of the modern information system. The R&D in the database system moves along by giant steps. This report presents the achievements Renmin University of China (RUC) has made in the past 25 years and at the same time addresses some of the research projects we, RUC, are currently working on. The National Natural Science Foundation of China supports and initiates most of our research projects and these successfully conducted projects have produced fruitful results.

  13. Predicting educational achievement from DNA (United States)

    Selzam, S; Krapohl, E; von Stumm, S; O'Reilly, P F; Rimfeld, K; Kovas, Y; Dale, P S; Lee, J J; Plomin, R


    A genome-wide polygenic score (GPS), derived from a 2013 genome-wide association study (N=127,000), explained 2% of the variance in total years of education (EduYears). In a follow-up study (N=329,000), a new EduYears GPS explains up to 4%. Here, we tested the association between this latest EduYears GPS and educational achievement scores at ages 7, 12 and 16 in an independent sample of 5825 UK individuals. We found that EduYears GPS explained greater amounts of variance in educational achievement over time, up to 9% at age 16, accounting for 15% of the heritable variance. This is the strongest GPS prediction to date for quantitative behavioral traits. Individuals in the highest and lowest GPS septiles differed by a whole school grade at age 16. Furthermore, EduYears GPS was associated with general cognitive ability (~3.5%) and family socioeconomic status (~7%). There was no evidence of an interaction between EduYears GPS and family socioeconomic status on educational achievement or on general cognitive ability. These results are a harbinger of future widespread use of GPS to predict genetic risk and resilience in the social and behavioral sciences. PMID:27431296

  14. Rapid chemical separations

    CERN Document Server

    Trautmann, N


    A survey is given on the progress of fast chemical separation procedures during the last few years. Fast, discontinuous separation techniques are illustrated by a procedure for niobium. The use of such techniques for the chemical characterization of the heaviest known elements is described. Other rapid separation methods from aqueous solutions are summarized. The application of the high speed liquid chromatography to the separation of chemically similar elements is outlined. The use of the gas jet recoil transport method for nuclear reaction products and its combination with a continuous solvent extraction technique and with a thermochromatographic separation is presented. Different separation methods in the gas phase are briefly discussed and the attachment of a thermochromatographic technique to an on-line mass separator is shown. (45 refs).

  15. Rapid Diagnosis of Malaria

    Directory of Open Access Journals (Sweden)

    Clinton K. Murray


    Full Text Available Malaria's global impact is expansive and includes the extremes of the healthcare system ranging from international travelers returning to nonendemic regions with tertiary referral medical care to residents in hyperendemic regions without access to medical care. Implementation of prompt and accurate diagnosis is needed to curb the expanding global impact of malaria associated with ever-increasing antimalarial drug resistance. Traditionally, malaria is diagnosed using clinical criteria and/or light microscopy even though both strategies are clearly inadequate in many healthcare settings. Hand held immunochromatographic rapid diagnostic tests (RDTs have been recognized as an ideal alternative method for diagnosing malaria. Numerous malaria RDTs have been developed and are widely available; however, an assortment of issues related to these products have become apparent. This review provides a summary of RDT including effectiveness and strategies to select the ideal RDT in varying healthcare settings.

  16. Rapid automated nuclear chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, R.A.


    Rapid Automated Nuclear Chemistry (RANC) can be thought of as the Z-separation of Neutron-rich Isotopes by Automated Methods. The range of RANC studies of fission and its products is large. In a sense, the studies can be categorized into various energy ranges from the highest where the fission process and particle emission are considered, to low energies where nuclear dynamics are being explored. This paper presents a table which gives examples of current research using RANC on fission and fission products. The remainder of this text is divided into three parts. The first contains a discussion of the chemical methods available for the fission product elements, the second describes the major techniques, and in the last section, examples of recent results are discussed as illustrations of the use of RANC.

  17. Rapid Refresh (RAP) [20 km (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Refresh (RAP) numerical weather model took the place of the Rapid Update Cycle (RUC) on May 1, 2012. Run by the National Centers for Environmental...

  18. Rapid Refresh (RAP) [13 km (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Refresh (RAP) numerical weather model took the place of the Rapid Update Cycle (RUC) on May 1, 2012. Run by the National Centers for Environmental...

  19. Koszul differential graded modules

    Institute of Scientific and Technical Information of China (English)

    HE JiWei; WU QuanShui


    The concept of Koszulity for differential graded (DG, for short) modules is introduced. It is shown that any bounded below DG module with bounded Ext-group to the trivial module over a Koszul DG algebra has a Koszul DG submodule (up to a shift and truncation), moreover such a DG module can be approximated by Koszul DG modules (Theorem 3.6). Let A be a Koszul DG algebra, and Dc (A) be the full triangulated subcategory of the derived category of DG A-modules generated by the object AA. If the trivial DG module kA lies in Dc(A), then the heart of the standard t-structure on Dc(A) is anti-equivalent to the category of finitely generated modules over some finite dimensional algebra. As a corollary, Dc(A) is equivalent to the bounded derived category of its heart as triangulated categories.

  20. Koszul differential graded modules

    Institute of Scientific and Technical Information of China (English)


    The concept of Koszulity for differential graded (DG, for short) modules is introduced. It is shown that any bounded below DG module with bounded Ext-group to the trivial module over a Koszul DG algebra has a Koszul DG submodule (up to a shift and truncation), moreover such a DG module can be approximated by Koszul DG modules (Theorem 3.6). Let A be a Koszul DG algebra, and Dc(A) be the full triangulated subcategory of the derived category of DG A-modules generated by the object AA. If the trivial DG module kA lies in Dc(A), then the heart of the standard t-structure on Dc(A) is anti-equivalent to the category of finitely generated modules over some finite dimensional algebra. As a corollary, Dc(A) is equivalent to the bounded derived category of its heart as triangulated categories.

  1. A paradigm shift in enteric coating: achieving rapid release in the proximal small intestine of man. (United States)

    Liu, Fang; Basit, Abdul W


    The in vivo performance of a novel enteric double-coating technology designed to accelerate release in the proximal small intestine of humans was investigated. Tablet cores were coated with a double layer formulation consisting of an inner layer of EUDRAGIT L 30 D-55 neutralised to pH 6.0 in the presence of 10% citric acid, and an outer layer of standard EUDRAGIT L 30 D-55. A conventional single coating of EUDRAGIT L 30 D-55 was also applied to tablets for comparison purposes, with the identical coating formulation and thickness (5mg/cm(2)) as the outer layer of the double coating. Eight fasted volunteers received the double-coated and single-coated tablets in a two-way crossover study. The formulations were radiolabelled and followed by gamma scintigraphy; the disintegration times and positions were recorded. After leaving the stomach, tablets coated with the single-coating formulation showed a significant time delay before disintegration occurred in the mid to distal small intestine, with a mean disintegration time of 66 ± 22 min post gastric emptying. The double-coated tablets disintegrated earlier at 28 ± 6min post gastric emptying with consistent disintegration in the proximal small intestine. The accelerated in vivo disintegration of the double-coating system can overcome the limitations of conventional enteric coatings.

  2. Direct-Digital-Drive Microring Modulator

    CERN Document Server

    Ehrlichman, Yossef; Ruschin, Shlomo


    The method of Direct Digital Drive is applied to a microring resonator. The microring resonator is thus controlled by a segmented set of electrodes each of which is driven by binary (digital) signal. Digital linearization is performed with the aid of digital memory lookup table. The method is applied to a single microring modulator to provide an M-bit digital-toanalog converter (DAC), which may also be viewed as an M-level pulse amplitude modulator (M-PAM). It is shown, by means of simulation, that a 4-bit DAC can achieve an effective number of bits (ENOB) of 3.74bits. Applying the same method for two rings, enables the generation of two-dimensional optical M-QAM signals. It is shown, by means of simulation, that a 16-QAM modulator achieves an EVM better than -30dB.

  3. On Matlis dualizing modules

    Directory of Open Access Journals (Sweden)

    Edgar E. Enochs


    Full Text Available We consider rings admitting a Matlis dualizing module E. We argue that if R admits two such dualizing modules, then a module is reflexive with respect to one if and only if it is reflexive with respect to the other. Using this fact we argue that the number (whether finite or infinite of distinct dualizing modules equals the number of distinct invertible (R,R-bimodules. We show by example that this number can be greater than one.

  4. Divisive gain modulation of motoneurons by inhibition optimizes muscular control

    DEFF Research Database (Denmark)

    Vestergaard, Mikkel; Berg, Rune W.


    regulated on a subsecond timescale, it is also adjusted to minimize variability. The modulation is likely achieved via an expansive nonlinearity between spike rate and membrane potential with inhibition having a divisive influence. These findings reveal a versatile mechanism of modulating neuronal...

  5. Irreducible quantum group modules with finite dimensional weight spaces

    DEFF Research Database (Denmark)

    Pedersen, Dennis Hasselstrøm

    a finitely generated U q -module which has finite dimensional weight spaces and is a sum of those. Our approach follows the procedures used by S. Fernando and O. Mathieu to solve the corresponding problem for semisimple complex Lie algebra modules. To achieve this we have to overcome a number of obstacles...

  6. Forward SCT Module Assembly and Quality Control at IFIC Valencia

    CERN Document Server

    Mitsou, V A; Civera, J V; Costa, M J; Escobar, C; Fuster, J; García, C; García-Navarro, J E; González, F; González-Sevilla, S; Lacasta, C; Llosá, G; Martí i García, S; Miñano, M; Modesto, P; Nácher, J; Rodríguez-Oliete, R; Sánchez, F J; Sospedra, L; Strachko, V


    This note discusses the assembly and the quality control tests of 282 forward detector modules for the ATLAS Semiconductor Tracker assembled at the Instituto de Fisica Corpuscular (IFIC) in Valencia. The construction and testing procedures are outlined and the laboratory equipment is briefly described. Emphasis is given on the module quality achieved in terms of mechanical and electrical stability.

  7. MI 6040 Thermoelectric Modules. (United States)

    The report covers the design justification, physical specification and characterization of the MI 6040 module . The purpose of the thermoelectric... modules is the cooling of infrared detector arrays to temperature of 170K or colder. The completed modules were also subjected to limited demonstration tests of reliability and useful life.

  8. Polarization modulators for CMBPol

    Energy Technology Data Exchange (ETDEWEB)

    Ade, P A R; Savini, G [Cardiff University, School of Physics and Astronomy, Queens Buildings, The Parade, Cardiff, CF24 3AA (United Kingdom); Chuss, D T [NASA Goddard Space Flight Center, Code 665, Greenbelt, MD, 20771 (United States); Hanany, S [School of Physics and Astronomy, University of Minnesota/Twin Cities, Minneapolis, MN, 55455 (United States); Haynes, V; Pisano, G [University of Manchester, School of Physics and Astronomy - Alan Turing Building, Upper Brooke street, Manchester, M13 4PL (United Kingdom); Keating, B G [Department of Physics, University of California, San Diego, La Jolla, CA 92093-0424 (United States); Kogut, A [Code 665 Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Ruhl, J E [Physics Department, Case Western Reserve University, Cleveland, OH, 44106 (United States); Wollack, E J [Observational Cosmology Laboratory, NASA/GSFC, Greenbelt, MD 20771 (United States)


    We review a number of technologies that are candidates for active polarization modulators for CMBPol. The technologies are appropriate for instruments that use bolometric detectors and include birefringent crystal-based and metal-mesh-based half-wave plates, variable phase polarization modulator, Faraday rotator, and photolithographed modulators. We also give a current account of the status of millimeter-wave orthomode transducers.

  9. Modulating lignin in plants (United States)

    Apuya, Nestor; Bobzin, Steven Craig; Okamuro, Jack; Zhang, Ke


    Materials and methods for modulating (e.g., increasing or decreasing) lignin content in plants are disclosed. For example, nucleic acids encoding lignin-modulating polypeptides are disclosed as well as methods for using such nucleic acids to generate transgenic plants having a modulated lignin content.

  10. Relatively Endocoherent Modules

    Institute of Scientific and Technical Information of China (English)

    Lixin Mao


    Let MR be a right R-module over a ring R with S= End(MR)We study the coherence of the left S-module sM relative to a torsion theory for the category of right R-modules.Various results are developed, many extending known results.

  11. The Use of Uas for Rapid 3d Mapping in Geomatics Education (United States)

    Teo, Tee-Ann; Tian-Yuan Shih, Peter; Yu, Sz-Cheng; Tsai, Fuan


    With the development of technology, UAS is an advance technology to support rapid mapping for disaster response. The aim of this study is to develop educational modules for UAS data processing in rapid 3D mapping. The designed modules for this study are focused on UAV data processing from available freeware or trial software for education purpose. The key modules include orientation modelling, 3D point clouds generation, image georeferencing and visualization. The orientation modelling modules adopts VisualSFM to determine the projection matrix for each image station. Besides, the approximate ground control points are measured from OpenStreetMap for absolute orientation. The second module uses SURE and the orientation files from previous module for 3D point clouds generation. Then, the ground point selection and digital terrain model generation can be archived by LAStools. The third module stitches individual rectified images into a mosaic image using Microsoft ICE (Image Composite Editor). The last module visualizes and measures the generated dense point clouds in CloudCompare. These comprehensive UAS processing modules allow the students to gain the skills to process and deliver UAS photogrammetric products in rapid 3D mapping. Moreover, they can also apply the photogrammetric products for analysis in practice.


    Directory of Open Access Journals (Sweden)

    T.-A. Teo


    Full Text Available With the development of technology, UAS is an advance technology to support rapid mapping for disaster response. The aim of this study is to develop educational modules for UAS data processing in rapid 3D mapping. The designed modules for this study are focused on UAV data processing from available freeware or trial software for education purpose. The key modules include orientation modelling, 3D point clouds generation, image georeferencing and visualization. The orientation modelling modules adopts VisualSFM to determine the projection matrix for each image station. Besides, the approximate ground control points are measured from OpenStreetMap for absolute orientation. The second module uses SURE and the orientation files from previous module for 3D point clouds generation. Then, the ground point selection and digital terrain model generation can be archived by LAStools. The third module stitches individual rectified images into a mosaic image using Microsoft ICE (Image Composite Editor. The last module visualizes and measures the generated dense point clouds in CloudCompare. These comprehensive UAS processing modules allow the students to gain the skills to process and deliver UAS photogrammetric products in rapid 3D mapping. Moreover, they can also apply the photogrammetric products for analysis in practice.

  13. Achieving Universal Access to Broadband

    Directory of Open Access Journals (Sweden)

    Morten FALCH


    Full Text Available The paper discusses appropriate policy measures for achieving universal access to broadband services in Europe. Access can be delivered by means of many different technology solutions described in the paper. This means a greater degree of competition and affects the kind of policy measures to be applied. The paper concludes that other policy measure than the classical universal service obligation are in play, and discusses various policy measures taking the Lisbon process as a point of departure. Available policy measures listed in the paper include, universal service obligation, harmonization, demand stimulation, public support for extending the infrastructure, public private partnerships (PPP, and others.

  14. Towards unified description of shell evolution — Takaharu Otsuka's achievements (United States)

    Utsuno, Y.


    Recent studies on exotic nuclei have rapidly advanced the understanding of the evolution of shell structure, to which Takaharu Otsuka has made remarkable contributions particularly in terms of the nuclear force. This paper presents a brief survey of his achievements, focused on the concept of shell evolution due to the tensor force and the three-nucleon force and on related shell-model works.

  15. Achieving success: moving beyond the comfort level. (United States)

    Manji, I


    Understanding the stages of growth, saturation and transition is the first step to setting meaningful career goals. While this concept is fairly new in dentistry, it is not new in other commercial enterprises. Business managers and owners have known for decades that growth stagnates after a period of time. At that point, a new infusion of energy and a reformation of the business's objectives and methods are needed to launch forward into the next phase of growth. Transition management in dentistry represents periods of growth that are followed by saturation and a comparatively rapid changeover to a new practice form. Saturation occurs when the clinical capacity of a practice is exceeded by the needs of a growing patient base. The key transitions in the career of a dentist are those from school to practising, and practising to retirement. A great number of dentists (due to low motivation, the comfort level or poor management skills) never reach the saturation point during their practising career. For these dentists, starting out and retirement are the only transitions that will ever apply to them. Dentists evaluating transition options must first identify which career stage they belong to since their objectives will be different at each stage. Dentists in the growth phase should focus on practice management and achieving saturation before attempting a transition. Since transitions like start-up, retirement, partnerships, associateships and buy-ins have pivotal roles in the life cycle of a practice, transitions must be managed carefully to achieve successful results.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. Building a rapid response team. (United States)

    Halvorsen, Lisa; Garolis, Salomeja; Wallace-Scroggs, Allyson; Stenstrom, Judy; Maunder, Richard


    The use of rapid response teams is a relatively new approach for decreasing or eliminating codes in acute care hospitals. Based on the principles of a code team for cardiac and/or respiratory arrest in non-critical care units, the rapid response teams have specially trained nursing, respiratory, and medical personnel to respond to calls from general care units to assess and manage decompensating or rapidly changing patients before their conditions escalate to a full code situation. This article describes the processes used to develop a rapid response team, clinical indicators for triggering a rapid response team call, topics addressed in an educational program for the rapid response team members, and methods for evaluating effectiveness of the rapid response team.

  17. Divisible ℤ-modules

    Directory of Open Access Journals (Sweden)

    Futa Yuichi


    Full Text Available In this article, we formalize the definition of divisible ℤ-module and its properties in the Mizar system [3]. We formally prove that any non-trivial divisible ℤ-modules are not finitely-generated.We introduce a divisible ℤ-module, equivalent to a vector space of a torsion-free ℤ-module with a coefficient ring ℚ. ℤ-modules are important for lattice problems, LLL (Lenstra, Lenstra and Lovász base reduction algorithm [15], cryptographic systems with lattices [16] and coding theory [8].

  18. Experimental Investigations of 3-D-/4-D-CAP Modulation With Directly Modulated VCSELs

    DEFF Research Database (Denmark)

    Binti Othman, Maisara; Zhang, Xu; Deng, Lei;


    In this letter, we present experimental investigations of multidimensional multilevel carrierless amplitude phase (CAP) modulation with directly modulated vertical cavity surface-emitting lasers. The signals are transmitted over 20 km of standard single-mode fiber (SSMF). For multilevel 3-D......-CAP, bit rates of 468.75 and 937.5 Mb/s are achieved at two levels/dimension and four levels/dimension, respectively. For 4-D-CAP, bit rates of 416.67 and 833.3 Mb/s are achieved at two levels/dimension and four levels/dimension, respectively. For all signals, a bit-error rate below the forward error...

  19. Teacher Quality and Student Achievement

    Directory of Open Access Journals (Sweden)

    Linda Darling-Hammond


    Full Text Available Using data from a 50-state survey of policies, state case study analyses, the 1993-94 Schools and Staffing Surveys (SASS, and the National Assessment of Educational Progress (NAEP, this study examines the ways in which teacher qualifications and other school inputs are related to student achievement across states. The findings of both the qualitative and quantitative analyses suggest that policy investments in the quality of teachers may be related to improvements in student performance. Quantitative analyses indicate that measures of teacher preparation and certification are by far the strongest correlates of student achievement in reading and mathematics, both before and after controlling for student poverty and language status. State policy surveys and case study data are used to evaluate policies that influence the overall level of teacher qualifications within and across states. This analysis suggests that policies adopted by states regarding teacher education, licensing, hiring, and professional development may make an important difference in the qualifications and capacities that teachers bring to their work. The implications for state efforts to enhance quality and equity in public education are discussed.

  20. Updates and achievements in virology. (United States)

    Buonaguro, Franco M; Campadelli-Fiume, Gabriella; De Giuli Morghen, Carlo; Palù, Giorgio


    The 4th European Congress of Virology, hosted by the Italian Society for Virology, attracted approximately 1300 scientists from 46 countries worldwide. It also represented the first conference of the European Society for Virology, which was established in Campidoglio, Rome, Italy in 2009. The main goal of the meeting was to share research activities and results achieved in European virology units/institutes and to strengthen collaboration with colleagues from both western and developing countries. The worldwide representation of participants is a testament to the strength and attraction of European virology. The 5-day conference brought together the best of current virology; topics covered all three living domains (bacteria, archaea and eucarya), with special sessions on plant and veterinary virology as well as human virology, including two oral presentations on mimiviruses. The conference included five plenary sessions, 31 workshops, one hepatitis C virus roundtable, ten special workshops and three poster sessions, as well as 45 keynote lectures, 191 oral presentations and 845 abstracts. Furthermore, the Gesellschaft fur Virologie Loeffler-Frosch medal award was given to Peter Vogt for his long-standing career and achievements; the Gardner Lecture of the European Society for Clinical Virology was presented by Yoshihiro Kawaoka, and the Pioneer in Virology Lecture of the Italian Society for Virology was presented by Ulrich Koszinowski.

  1. Rapidly rotating red giants

    CERN Document Server

    Gehan, Charlotte; Michel, Eric


    Stellar oscillations give seismic information on the internal properties of stars. Red giants are targets of interest since they present mixed modes, which behave as pressure modes in the convective envelope and as gravity modes in the radiative core. Mixed modes thus directly probe red giant cores, and allow in particular the study of their mean core rotation. The high-quality data obtained by CoRoT and Kepler satellites represent an unprecedented perspective to obtain thousands of measurements of red giant core rotation, in order to improve our understanding of stellar physics in deep stellar interiors. We developed an automated method to obtain such core rotation measurements and validated it for stars on the red giant branch. In this work, we particularly focus on the specific application of this method to red giants having a rapid core rotation. They show complex spectra where it is tricky to disentangle rotational splittings from mixed-mode period spacings. We demonstrate that the method based on the id...

  2. Rapid Polymer Sequencer (United States)

    Stolc, Viktor (Inventor); Brock, Matthew W (Inventor)


    Method and system for rapid and accurate determination of each of a sequence of unknown polymer components, such as nucleic acid components. A self-assembling monolayer of a selected substance is optionally provided on an interior surface of a pipette tip, and the interior surface is immersed in a selected liquid. A selected electrical field is impressed in a longitudinal direction, or in a transverse direction, in the tip region, a polymer sequence is passed through the tip region, and a change in an electrical current signal is measured as each polymer component passes through the tip region. Each of the measured changes in electrical current signals is compared with a database of reference electrical change signals, with each reference signal corresponding to an identified polymer component, to identify the unknown polymer component with a reference polymer component. The nanopore preferably has a pore inner diameter of no more than about 40 nm and is prepared by heating and pulling a very small section of a glass tubing.

  3. Rapidly Evolving Giant Dermatofibroma

    Directory of Open Access Journals (Sweden)

    K. J. Lang


    Full Text Available Dermatofibroma, also known as “fibrous histiocytoma”, is a benign dermal or subcutaneous poorly circumscribed proliferation of spindle-shaped fibroblasts and macrophages in the dermis. Although it is commonly present as a brownish nodule the legs of females, it may also arise on the upper extremities, trunk, and rarely on the head. The exact pathogenesis is unclear. However, it is widely believed that the originating insult to the dermis is a folliculitis, an arthropod bite, or an unspecified initial inflammatory condition. Giant dermatofibromas of greater than 5 cm in diameter are rare, with only 22 cases reported in the literature. We present a case of a rapidly evolving pedunculated mass in the groin of a male patient. Histological examination confirmed this to be a giant dermatofibroma. Though this specimen cannot is not confirmed as such, the cellular subtype is sometimes present as a larger lesion with anecdotal reports of local recurrence and distant metastases. The clinical and radiological features which were somewhat suspicious of malignancy are considered in the context of the definitive pathological diagnosis of a benign lesion.

  4. Reduced Multiplication Modules

    Indian Academy of Sciences (India)

    Karim Samei


    An -module is called a multiplication module if for each submodule of , = for some ideal of . As defined for a commutative ring , an -module is said to be reduced if the intersection of prime submodules of is zero. The prime spectrum and minimal prime submodules of the reduced module are studied. Essential submodules of are characterized via a topological property. It is shown that the Goldie dimension of is equal to the Souslin number of Spec (). Also a finitely generated module is a Baer module if and only if Spec () is an extremally disconnected space; if and only if it is a -module. It is proved that a prime submodule is minimal in if and only if for each $x\\in N,\\mathrm{Ann}(x)\

  5. Solar cell module. Taiyo denchi module

    Energy Technology Data Exchange (ETDEWEB)

    Nakano, Akihiko.


    This invention concerns a module frame of solar cell and a solar cell module using this frame. In particular, it concerns a frame and a module useful for the CdS/CdTe or CdS/CuInSe {sub 2} based cell. In the existing solar cell module, sealant is packed in between the edges of a glass substrate, a resin layer and a back protective thin film, etc. and a grooved frame of U-shaped section. For the sealant, silicon based resin and butyl rubber based resin are used many times, but either resin has defects such as their overflow from the module structure. In order to solve these defects, this invention proposes to provide stair-shaped protrusions along the four sides of the bottom of the box frame (herein after called the lower frame) of the module and at the same time, provide a groove for pooling the sealant at the portion where such protrusion meets the side wall, furthermore to provide depressions for pooling the sealant at the upper edge inside the side wall of the lower frame or to punch holes at the corners of the bottom of the lower frame. 9 figs.

  6. Rapid Tooling Technique Based on Stereolithograph Prototype

    Institute of Scientific and Technical Information of China (English)

    丁浩; 狄平; 顾伟生; 朱世根


    Rapid tooling technique based on the sterelithograph prototype is investigated. The epoxy tooling technological process was elucidated. It is analyzed in detail that the epoxy resin formula is easy to cast, curing process, and release agents. The transitional plaster model is also proposed. The mold to encrust mutual.inductors with epoxy and mold to inject plastic soapboxes was made with the technique The tooling needs very little time and cost, for the process is only to achieve the nice replica of the prototype. It is benefit for the trial and small batch of production.

  7. A Method of Clustering Components into Modules Based on Products' Functional and Structural Analysis

    Institute of Scientific and Technical Information of China (English)

    MENG Xiang-hui; JIANG Zu-hua; ZHENG Ying-fei


    Modularity is the key to improving the cost-variety trade-off in product development. To achieve the functional independency and structural independency of modules, a method of clustering components to identify modules based on functional and structural analysis was presented. Two stages were included in the method. In the first stage the products' function was analyzed to determine the primary level of modules. Then the objective function for modules identifying was formulated to achieve functional independency of modules. Finally the genetic algorithm was used to solve the combinatorial optimization problem in modules identifying to form the primary modules of products. In the second stage the cohesion degree of modules and the coupling degree between modules were analyzed. Based on this structural analysis the modular scheme was refined according to the thinking of structural independency. A case study on the gear reducer was conducted to illustrate the validity of the presented method.

  8. Low cost solar array project production process and equipment task. A Module Experimental Process System Development Unit (MEPSDU) (United States)


    Technical readiness for the production of photovoltaic modules using single crystal silicon dendritic web sheet material is demonstrated by: (1) selection, design and implementation of solar cell and photovoltaic module process sequence in a Module Experimental Process System Development Unit; (2) demonstration runs; (3) passing of acceptance and qualification tests; and (4) achievement of a cost effective module.

  9. Hermetic diode laser transmitter module (United States)

    Ollila, Jyrki; Kautio, Kari; Vahakangas, Jouko; Hannula, Tapio; Kopola, Harri K.; Oikarinen, Jorma; Sivonen, Matti


    In very demanding optoelectronic sensor applications it is necessary to encapsulate semiconductor components hermetically in metal housings to ensure reliable operation of the sensor. In this paper we report on the development work to package a laser diode transmitter module for a time- off-light distance sensor application. The module consists of a lens, laser diode, electronic circuit and optomechanics. Specifications include high acceleration, -40....+75 degree(s)C temperature range, very low gas leakage and mass-production capability. We have applied solder glasses for sealing optical lenses and electrical leads hermetically into a metal case. The lens-metal case sealing has been made by using a special soldering glass preform preserving the optical quality of the lens. The metal housings are finally sealed in an inert atmosphere by welding. The assembly concept to retain excellent optical power and tight optical axis alignment specifications is described. The reliability of the laser modules manufactured has been extensively tested using different aging and environmental test procedures. Sealed packages achieve MIL- 883 standard requirements for gas leakage.

  10. Progress, Wealth, and Mathematics Achievement

    DEFF Research Database (Denmark)

    Valero, Paola


    international mathematics education journal (Laisant & Fehr, 1899). In the times of the Cold War, a similar argument emerged, however the justification was related to keeping the supremacy of the Capitalist West in front of the growing menace of the expansion of the Communist Soviet Union. Nowadays...... as a result, among others, of the growing series of comparative information on educational achievement and development. Such reports can be seen as performances of the comparative logic of Modernity that operates differential positioning, not only among individuals but also among nations, with respect to what...... is considered to be the desired and normal level of development and growth. “Mathematics for all” can be seen as an effect of power that operates on subjects and nations alike to determine who are the individuals/nations who excel, while creating a narrative of inclusion for all those who, by the very same...

  11. WDM Phase-Modulated Millimeter-Wave Fiber Systems

    DEFF Research Database (Denmark)

    Yu, Xianbin; Prince, Kamau; Gibbon, Timothy Braidwood


    This chapter presents a computer simulation case study of two typical WDM phase-modulated millimeter-wave systems. The phase-modulated 60 GHz fiber multi-channel transmission systems employ single sideband (SSB) and double sideband subcarrier modulation (DSB-SC) schemes and present one of the lat......This chapter presents a computer simulation case study of two typical WDM phase-modulated millimeter-wave systems. The phase-modulated 60 GHz fiber multi-channel transmission systems employ single sideband (SSB) and double sideband subcarrier modulation (DSB-SC) schemes and present one...... of the latest research efforts in the rapidly emerging Radio-over-Fiber (RoF) application space for in-house access networks....

  12. Novel electro-optical phase modulator based on GaInAs/InP modulation-doped quantum-well structures

    DEFF Research Database (Denmark)

    Thirstrup, C.


    A novel electro-optical phase modulator working at 1.55 µm is analyzed and proposed. It is shown by a numerical model that in a GaInAs/InP pn-nin-pn multiple-quantum-well waveguide structure, large optical phase modulation can be obtained at small intensity modulation and with improved performance...... compared to what is achieved in quantum confined Stark effect modulators of the same material system. The device proposed is based on a modulation of the quasi-Fermi energies of the electrons in the GaInAs quantum wells. This operational principle allows GHz modulation frequencies. Applied Physics Letters...

  13. Urban flood risk warning under rapid urbanization. (United States)

    Chen, Yangbo; Zhou, Haolan; Zhang, Hui; Du, Guoming; Zhou, Jinhui


    In the past decades, China has observed rapid urbanization, the nation's urban population reached 50% in 2000, and is still in steady increase. Rapid urbanization in China has an adverse impact on urban hydrological processes, particularly in increasing the urban flood risks and causing serious urban flooding losses. Urban flooding also increases health risks such as causing epidemic disease break out, polluting drinking water and damaging the living environment. In the highly urbanized area, non-engineering measurement is the main way for managing urban flood risk, such as flood risk warning. There is no mature method and pilot study for urban flood risk warning, the purpose of this study is to propose the urban flood risk warning method for the rapidly urbanized Chinese cities. This paper first presented an urban flood forecasting model, which produces urban flood inundation index for urban flood risk warning. The model has 5 modules. The drainage system and grid dividing module divides the whole city terrain into drainage systems according to its first-order river system, and delineates the drainage system into grids based on the spatial structure with irregular gridding technique; the precipitation assimilation module assimilates precipitation for every grids which is used as the model input, which could either be the radar based precipitation estimation or interpolated one from rain gauges; runoff production module classifies the surface into pervious and impervious surface, and employs different methods to calculate the runoff respectively; surface runoff routing module routes the surface runoff and determines the inundation index. The routing on surface grid is calculated according to the two dimensional shallow water unsteady flow algorithm, the routing on land channel and special channel is calculated according to the one dimensional unsteady flow algorithm. This paper then proposed the urban flood risk warning method that is called DPSIR model based

  14. Quadrupole magnet for a rapid cycling synchrotron

    Energy Technology Data Exchange (ETDEWEB)

    Witte, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Berg, J. S. [Brookhaven National Lab. (BNL), Upton, NY (United States)


    Rapid Cycling Synchrotrons (RCS) feature interleaved warm and cold dipole magnets; the field of the warm magnets is used to modulate the average bending field depending on the particle energy. It has been shown that RCS can be an attractive option for fast acceleration of particles, for example, muons, which decay quickly. In previous studies it was demonstrated that in principle warm dipole magnets can be designed which can provide the required ramp rates, which are equivalent to frequencies of about 1 kHz. To reduce the losses it is beneficial to employ two separate materials for the yoke; it was also shown that by employing an optimized excitation coil geometry the eddy current losses are acceptable. In this paper we show that the same principles can be applied to quadrupole magnets targeting 30 T/m with a repetition rate of 1kHz and good field quality.

  15. Rapidly Moving Divertor Plates In A Tokamak

    Energy Technology Data Exchange (ETDEWEB)

    S. Zweben


    It may be possible to replace conventional actively cooled tokamak divertor plates with a set of rapidly moving, passively cooled divertor plates on rails. These plates would absorb the plasma heat flux with their thermal inertia for ~10-30 sec, and would then be removed from the vessel for processing. When outside the tokamak, these plates could be cooled, cleaned, recoated, inspected, and then returned to the vessel in an automated loop. This scheme could provide nearoptimal divertor surfaces at all times, and avoid the need to stop machine operation for repair of damaged or eroded plates. We describe various possible divertor plate designs and access geometries, and discuss an initial design for a movable and removable divertor module for NSTX-U.

  16. Implementation of re-configurable Digital front end module of MIMO-OFDM module using NCO

    Directory of Open Access Journals (Sweden)

    Veena M.B.


    Full Text Available This paper focuses on FPGA implementation of Reconfigurable Digital Front end MIMO-OFDM module. The modeling of the MIMO-OFDM system was carried out in MATLAB followed by Verilog HDL implementation. Unlike the conventional OFDM based systems, the Numerically Controlled Oscillators (NCO is used for mapping modulated data onto the sub carriers. The use of NCO in the MIMO-OFDM system reduces the resource utilization of the design on FPGA along with reduced power consumption. The major modules that were designed, which constitute the digital front end module, are Quadrature Phase Shift Keying (QPSK modulator/demodulator, 16-Quadrature Amplitude Modulation (QAM modulator/demodulator and NCOs. Each of the modules was tested for their functionality by developing corresponding test benches. In order to achieve real time reconfigurability of the proposed architecture, the proposed approach is realized on FPGAs optimizing area, power and speed. Reconfigurability of the proposed approach is dependent upon user requirement. Hence the proposed approach can support future generation communication technologies that are based on MIMO-OFDM.

  17. Phase retrieval by coherent modulation imaging (United States)

    Zhang, Fucai; Chen, Bo; Morrison, Graeme R.; Vila-Comamala, Joan; Guizar-Sicairos, Manuel; Robinson, Ian K.


    Phase retrieval is a long-standing problem in imaging when only the intensity of the wavefield can be recorded. Coherent diffraction imaging is a lensless technique that uses iterative algorithms to recover amplitude and phase contrast images from diffraction intensity data. For general samples, phase retrieval from a single-diffraction pattern has been an algorithmic and experimental challenge. Here we report a method of phase retrieval that uses a known modulation of the sample exit wave. This coherent modulation imaging method removes inherent ambiguities of coherent diffraction imaging and uses a reliable, rapidly converging iterative algorithm involving three planes. It works for extended samples, does not require tight support for convergence and relaxes dynamic range requirements on the detector. Coherent modulation imaging provides a robust method for imaging in materials and biological science, while its single-shot capability will benefit the investigation of dynamical processes with pulsed sources, such as X-ray free-electron lasers. PMID:27857061

  18. Phase retrieval by coherent modulation imaging (United States)

    Zhang, Fucai; Chen, Bo; Morrison, Graeme R.; Vila-Comamala, Joan; Guizar-Sicairos, Manuel; Robinson, Ian K.


    Phase retrieval is a long-standing problem in imaging when only the intensity of the wavefield can be recorded. Coherent diffraction imaging is a lensless technique that uses iterative algorithms to recover amplitude and phase contrast images from diffraction intensity data. For general samples, phase retrieval from a single-diffraction pattern has been an algorithmic and experimental challenge. Here we report a method of phase retrieval that uses a known modulation of the sample exit wave. This coherent modulation imaging method removes inherent ambiguities of coherent diffraction imaging and uses a reliable, rapidly converging iterative algorithm involving three planes. It works for extended samples, does not require tight support for convergence and relaxes dynamic range requirements on the detector. Coherent modulation imaging provides a robust method for imaging in materials and biological science, while its single-shot capability will benefit the investigation of dynamical processes with pulsed sources, such as X-ray free-electron lasers.

  19. Rapid Robot Design Validation Project (United States)

    National Aeronautics and Space Administration — Energid Technologies will create a comprehensive software infrastructure for rapid validation of robot designs. The software will support push-button validation...

  20. Rapid Robot Design Validation Project (United States)

    National Aeronautics and Space Administration — Energid Technologies will create a comprehensive software infrastructure for rapid validation of robotic designs. The software will support push-button validation...

  1. Maximum modulation of plasmon-guided modes by graphene gating

    DEFF Research Database (Denmark)

    Radko, Ilya; Bozhevolnyi, Sergey I.; Grigorenko, Alexander N.


    The potential of graphene in plasmonic electro-optical waveguide modulators has been investigated in detail by finite-element method modelling of various widely used plasmonic waveguiding configurations. We estimated the maximum possible modulation depth values one can achieve with plasmonic...... devices operating at telecom wavelengths and exploiting the optical Pauli blocking effect in graphene. Conclusions and guidelines for optimization of modulation/intrinsic loss trade-off have been provided and generalized for any graphene-based plasmonic waveguide modulators, which should help...

  2. Study on modulation techniques free of orthogonality restriction

    Institute of Scientific and Technical Information of China (English)


    The Nyquist rate is a limit of transmission for traditional modulation methods from orthogonality restriction. Nonorthogonal modulation techniques (NMT) is proposed, which removes the orthogonality restriction, and as a result, higher bandwidth efficiency than the traditional methods can be achieved. First, the symbol error rate of NMT is introduced by using estimation theory. Then the relation between bandwidth efficiency and signal to noise ratio is discussed. Finally, a design instance of NMT is present and numerical experiment is made. This study explores for new modulation methods and points out a widened direction for modulation theory and applications.

  3. Rigidity of tilting modules

    DEFF Research Database (Denmark)

    Haahr Andersen, Henning; Kaneda, Masaharu

    ) modules for $U_q$ are rigid, i.e., have identical radical and socle filtrations. Moreover, we obtain the same for a large class of Weyl modules for $U_q$. On the other hand, we give examples of non-rigid indecomposable tilting modules as well as non-rigid Weyl modules. These examples are for type $B_2......$ and in this case as well as for type $A_2$ we calculate explicitly the Loewy structure for all regular Weyl modules. We also demonstrate that these results carry over to the modular case when the highest weights in question are in the so-called Jantzen region. At the same time we show by examples that as soon...... as we leave this region non-rigid tilting modules do occur....

  4. Directed network modules

    CERN Document Server

    Pálla, G; Farkas, I J; Pollner, P; Vicsek, T; Derenyi, Imre; Farkas, Illes J.; Palla, Gergely; Pollner, Peter; Vicsek, Tamas


    A search technique locating network modules, i.e., internally densely connected groups of nodes in directed networks is introduced by extending the Clique Percolation Method originally proposed for undirected networks. After giving a suitable definition for directed modules we investigate their percolation transition in the Erdos-Renyi graph both analytically and numerically. We also analyse four real-world directed networks, including Google's own webpages, an email network, a word association graph and the transcriptional regulatory network of the yeast Saccharomyces cerevisiae. The obtained directed modules are validated by additional information available for the nodes. We find that directed modules of real-world graphs inherently overlap and the investigated networks can be classified into two major groups in terms of the overlaps between the modules. Accordingly, in the word-association network and among Google's webpages the overlaps are likely to contain in-hubs, whereas the modules in the email and t...


    Directory of Open Access Journals (Sweden)



    Full Text Available Pupils with cerebral palsy attend elementary education accordind to a regular and special teaching plan and program. Regular school curriculum was reformed in 1992, while special plan and program has not been changed and adapted according to pupil’s needs and capacities. Music is one of the best means of expressing oneself and plays a very important role in the development of every child, the child with cerebral palsy in particular.In order to test the possibility of pupils with cerebral palsy, with and without mental retardation, to apprehend the actual program content, we have conducted research on musical achievement of children with cerebral palsy. During 2007 a research was carried out, on the sample of 27 pupils with cerebral palsy and mild mental retardation who attended classes in the school “Miodrag Matikj”, and a sample of16 students with cerebral palsy without mental retardation who attended the school “Dr. Dragan Hercog” in Belgrade.Results of the research, as well as analysis of music curriculum content, indicated that the capacities of students with cerebral palsy to carry out the curriculum tasks require special approach and methodology. Therefore, we introduced some proposals to overcome the difficulties in fulfilling music curriculum demands of those pupils. We made special emphasis on the use of computer based Assistive technology which facilitates the whole process to a large extent.

  6. Academic Achievement Among Juvenile Detainees. (United States)

    Grigorenko, Elena L; Macomber, Donna; Hart, Lesley; Naples, Adam; Chapman, John; Geib, Catherine F; Chart, Hilary; Tan, Mei; Wolhendler, Baruch; Wagner, Richard


    The literature has long pointed to heightened frequencies of learning disabilities (LD) within the population of law offenders; however, a systematic appraisal of these observations, careful estimation of these frequencies, and investigation of their correlates and causes have been lacking. Here we present data collected from all youth (1,337 unique admissions, mean age 14.81, 20.3% females) placed in detention in Connecticut (January 1, 2010-July 1, 2011). All youth completed a computerized educational screener designed to test a range of performance in reading (word and text levels) and mathematics. A subsample (n = 410) received the Wide Range Achievement Test, in addition to the educational screener. Quantitative (scale-based) and qualitative (grade-equivalence-based) indicators were then analyzed for both assessments. Results established the range of LD in this sample from 13% to 40%, averaging 24.9%. This work provides a systematic exploration of the type and severity of word and text reading and mathematics skill deficiencies among juvenile detainees and builds the foundation for subsequent efforts that may link these deficiencies to both more formal, structured, and variable definitions and classifications of LD, and to other types of disabilities (e.g., intellectual disability) and developmental disorders (e.g., ADHD) that need to be conducted in future research.

  7. A photovoltaic module


    Krebs, Frederik C.; Sommer-Larsen, Peter


    The present invention relates to a photovoltaic module comprising a carrier substrate, said carrier substrate carrying a purely printed structure comprising printed positive and negative module terminals, a plurality of printed photovoltaic cell units each comprising one or more printed photovoltaic cells, wherein the plurality of printed photovoltaic cell units are electrically connected in series between the positive and the negative module terminals such that any two neighbouring photovolt...

  8. Investigating Quantum Modulation States (United States)


    3. DATES COVERED (From - To) OCT 2012 – SEP 2015 4. TITLE AND SUBTITLE INVESTIGATING QUANTUM MODULATION STATES 5a. CONTRACT NUMBER IN-HOUSE 5b...Coherent states are the most classical of quantum states. Generation and detection of their polarization and phase modulations are cipher maps message bits onto random blocks of bits producing modulated states that are intrinsically noisy. The ciphertext so generated is

  9. Pragmatic Approach to Adaptive Turbo Coded Modulation

    Institute of Scientific and Technical Information of China (English)

    左健存; 宋文涛; 罗汉文; 徐友云


    This paper presents a pragmatic adaptive scheme for TuCM over slowly fading channels. The adaptive scheme employs a single turbo coded modulator composed of a variable-rate turbo encoder and a variable-rate variable-power MQAM for all fading regions, so it has an acceptable complexity to implement. The optimal adaptive TuCM scheme is determined subject to various system constraints. Simulations have been performed to measure the performance of the scheme for different parameters. It is shown that adopting both the turbo coded modulator and the transmit power achieves a performance within 2.5 dB of the fading channel capacity.

  10. Synthetic focusing in ultrasound modulated tomography

    KAUST Repository

    Kuchment, Peter


    Several hybrid tomographic methods utilizing ultrasound modulation have been introduced lately. Success of these methods hinges on the feasibility of focusing ultrasound waves at an arbitrary point of interest. Such focusing, however, is difficult to achieve in practice. We thus propose a way to avoid the use of focused waves through what we call synthetic focusing, i.e. by reconstructing the would-be response to the focused modulation from the measurements corresponding to realistic unfocused waves. Examples of reconstructions from simulated data are provided. This non-technical paper describes only the general concept, while technical details will appear elsewhere. © 2010 American Institute of Mathematical Sciences.



  12. Delphi Accounts Receivable Module - (United States)

    Department of Transportation — Delphi accounts receivable module contains the following data elements, but are not limited to customer information, cash receipts, line of accounting details, bill...

  13. Model theory and modules

    CERN Document Server

    Prest, M


    In recent years the interplay between model theory and other branches of mathematics has led to many deep and intriguing results. In this, the first book on the topic, the theme is the interplay between model theory and the theory of modules. The book is intended to be a self-contained introduction to the subject and introduces the requisite model theory and module theory as it is needed. Dr Prest develops the basic ideas concerning what can be said about modules using the information which may be expressed in a first-order language. Later chapters discuss stability-theoretic aspects of module

  14. Simple structured illumination microscope setup with high acquisition speed by using a spatial light modulator. (United States)

    Förster, Ronny; Lu-Walther, Hui-Wen; Jost, Aurélie; Kielhorn, Martin; Wicker, Kai; Heintzmann, Rainer


    We describe a two-beam interference structured illumination fluorescence microscope. The novelty of the presented system lies in its simplicity. A programmable spatial light modulator (ferroelectric LCoS) in an intermediate image plane enables precise and rapid control of the excitation pattern in the specimen. The contrast of the projected light pattern is strongly influenced by the polarization state of the light entering the high NA objective. To achieve high contrast, we use a segmented polarizer. Furthermore, a mask with six holes blocks unwanted components in the spatial frequency spectrum of the illumination grating. Both these passive components serve their purpose in a simpler and almost as efficient way as active components. We demonstrate a lateral resolution of 114.2 ± 9.5 nm at a frame rate of 7.6 fps per reconstructed 2D slice.

  15. Simple structured illumination microscope setup with high acquisition speed by using a spatial light modulator

    CERN Document Server

    Förster, Ronny; Jost, Aurélie; Kielhorn, Martin; Wicker, Kai; Heintzmann, Rainer


    We describe a two-beam interference structured illumination fluorescence microscope. The novelty of the presented system lies in its simplicity. A programmable electro-optical spatial light modulator in an intermediate image plane enables precise and rapid control of the excitation pattern in the specimen. The contrast of the projected light pattern is strongly influenced by the polarization state of the light entering the high NA objective. To achieve high contrast, we use a segmented polarizer. Furthermore, a mask with six holes blocks unwanted components in the spatial frequency spectrum of the illumination grating. Both these passive components serve their purpose in a simpler and almost as efficient way as active components. We demonstrate a lateral resolution of 114.2 +- 9.5 nm at a frame rate of 7.6 fps per reconstructed 2D slice.

  16. A rapid and sensitive method for measuring N-acetylglucosaminidase activity in cultured cells.

    Directory of Open Access Journals (Sweden)

    Victor Mauri

    Full Text Available A rapid and sensitive method to quantitatively assess N-acetylglucosaminidase (NAG activity in cultured cells is highly desirable for both basic research and clinical studies. NAG activity is deficient in cells from patients with Mucopolysaccharidosis type IIIB (MPS IIIB due to mutations in NAGLU, the gene that encodes NAG. Currently available techniques for measuring NAG activity in patient-derived cell lines include chromogenic and fluorogenic assays and provide a biochemical method for the diagnosis of MPS IIIB. However, standard protocols require large amounts of cells, cell disruption by sonication or freeze-thawing, and normalization to the cellular protein content, resulting in an error-prone procedure that is material- and time-consuming and that produces highly variable results. Here we report a new procedure for measuring NAG activity in cultured cells. This procedure is based on the use of the fluorogenic NAG substrate, 4-Methylumbelliferyl-2-acetamido-2-deoxy-alpha-D-glucopyranoside (MUG, in a one-step cell assay that does not require cell disruption or post-assay normalization and that employs a low number of cells in 96-well plate format. We show that the NAG one-step cell assay greatly discriminates between wild-type and MPS IIIB patient-derived fibroblasts, thus providing a rapid method for the detection of deficiencies in NAG activity. We also show that the assay is sensitive to changes in NAG activity due to increases in NAGLU expression achieved by either overexpressing the transcription factor EB (TFEB, a master regulator of lysosomal function, or by inducing TFEB activation chemically. Because of its small format, rapidity, sensitivity and reproducibility, the NAG one-step cell assay is suitable for multiple procedures, including the high-throughput screening of chemical libraries to identify modulators of NAG expression, folding and activity, and the investigation of candidate molecules and constructs for applications in

  17. Achieving monospermy or preventing polyspermy?

    Directory of Open Access Journals (Sweden)

    Dale B


    Full Text Available Brian Dale Centre for Assisted Fertilization, Naples, Italy Abstract: Images of sea urchin oocytes with hundreds of spermatozoa attached to their surface have fascinated scientists for over a century and led to the idea that oocytes have evolved mechanisms to allow the penetration of one spermatozoon while repelling supernumerary spermatozoa. Popular texts have extrapolated this concept, to the mammals and amphibians, and in many cases to include all the Phyla. Here, it is argued that laboratory experiments, using sea urchin oocytes deprived of their extracellular coats and inseminated at high densities, are artifactual and that the experiments leading to the idea of a fast block to polyspermy are flawed. Under natural conditions, the number of spermatozoa at the site of fertilization is extremely low, compared with the numbers generated. The sperm:oocyte ratio is regulated first by dilution in externally fertilizing species and the female reproductive tract in those with internal fertilization, followed by a bottleneck created by the oocytes extracellular coats. In order to progress to the oocyte plasma membrane, the fertilizing spermatozoon must encounter and respond to a correct sequence of signals from the oocytes extracellular coats. Those that do not, are halted in their progression by defective signaling and fall to the wayside. Final success and entry is finely tuned by the spermatozoon anchoring to an actin-rich predetermined site on the plasma membrane. In this review, the variation in the form, function, and number of gametes produced across the animal kingdom and the many ways in which sperm–oocyte interactions are regulated to reduce numbers are discussed. Since in nature, final sperm:oocyte ratios approach unity it would appear that selective pressures have favored the achievement of monospermy, rather than the evolution of polyspermy preventing mechanisms. Keywords: monospermy, natural conditions, polyspermy, laboratory

  18. Reliability Technology to Achieve Insertion of Advanced Packaging (RELTECH) program (United States)

    Fayette, Daniel F.; Speicher, Patricia; Stoklosa, Mark J.; Evans, Jillian V.; Evans, John W.; Gentile, Mike; Pagel, Chuck A.; Hakim, Edward


    A joint military-commercial effort to evaluate multichip module (MCM) structures is discussed. The program, Reliability Technology to Achieve Insertion of Advanced Packaging (RELTECH), has been designed to identify the failure mechanisms that are possible in MCM structures. The RELTECH test vehicles, technical assessment task, product evaluation plan, reliability modeling task, accelerated and environmental testing, and post-test physical analysis and failure analysis are described. The information obtained through RELTECH can be used to address standardization issues, through development of cost effective qualification and appropriate screening criteria, for inclusion into a commercial specification and the MIL-H-38534 general specification for hybrid microcircuits.

  19. In-Space Rapid Manufacturing (United States)

    Cooper, Kenneth G.


    In-space manufacturing objectives are: (1) Develop and demonstrate capability to directly fabricate components in space using rapid prototyping technology - ceramics (alumina, silicon nitride, zirconia), metallics (stainless, inconel, etc.), high strength/temperature plastics (PEEK). and ABS plastics (starting point). (2) Perform material science experiments on rapid prototyping candidate materials in microgravity.

  20. Dimethyl Ether Sector Develops Rapidly

    Institute of Scientific and Technical Information of China (English)

    Zong Yangong


    @@ Rapid capacity expansion Dimethyl ether production in China has developed rapidly in recent years. The total capacity of dimethyl ether in China was only 31.8 thousand t/a in 2002, the output was around 20 thousand tons and the operating rate was 63%. The number of producers increased to over 30 in 2006.

  1. Measuring modulated luminescence using non-modulated stimulation: Ramping the sample period

    DEFF Research Database (Denmark)

    Poolton, N.R.J.; Bøtter-Jensen, L.; Andersen, C.E.;


    . Directly analogous results to LM-OSL can, however, be achieved with non-modulated excitation sources, by ramping the sample period (RSP) of luminescence detection. RSP-OSL has the distinct advantage over LM-OSL in that, since the excitation remains at full power, data accumulation times (that can...

  2. A solar module fabrication process for HALE solar electric UAVs

    Energy Technology Data Exchange (ETDEWEB)

    Carey, P.G.; Aceves, R.C.; Colella, N.J.; Williams, K.A. [Lawrence Livermore National Lab., CA (United States); Sinton, R.A. [Private Consultant, San Jose, CA (United States); Glenn, G.S. [Spectrolab, Inc., Sylmar, CA (United States)


    We describe a fabrication process used to manufacture high power-to-weight-ratio flexible solar array modules for use on high-altitude-long-endurance (HALE) solar-electric unmanned air vehicles (UAVs). These modules have achieved power-to-weight ratios of 315 and 396 W/kg for 150{mu}m-thick monofacial and 110{mu}m-thick bifacial silicon solar cells, respectively. These calculations reflect average module efficiencies of 15.3% (150{mu}m) and 14.7% (110{mu}m) obtained from electrical tests performed by Spectrolab, Inc. under AMO global conditions at 25{degrees}C, and include weight contributions from all module components (solar cells, lamination material, bypass diodes, interconnect wires, and adhesive tape used to attach the modules to the wing). The fabrication, testing, and performance of 32 m{sup 2} of these modules will be described.

  3. Design and preliminary test results of Daya Bay RPC modules

    Institute of Scientific and Technical Information of China (English)

    XU Ji-Lei; Logan Lebanowski; Cullen Newsom; Lin Shih-Kai; Jonathan Link; MA Lie-Hua; Viktor Pě(c); Vit Vorobel; CHEN Jin; LIU Jin-Chang; ZHOU Yong-Zhao; GUAN Meng-Yun; LIANG Hao; YANG Chang-Gen; WANG Yi-Fang; ZHANG Jia-Wen; LU Chang-Guo; Kirk McDonald; Robert Hackenburg; Kwong Lau


    Resistive Plate Chamber(RPC)modules will be used as one part of the cosmic muon veto system in the Days Bay reactor neutrino experiment.A total of 189 RPC modules will cover the three water pools in the experiment.To achieve track reconstruction and high efficiency,each module consists of 4 layers,each of which contains two sizes of bare chambers.The placement of bare chambers is reversed in different layers to reduce the overlapping dead areas.The module efficiency and patch efficiency were studied both in simulation and test of the data analysis.143 modules have been constructed and tested.The preliminary study shows that the module and patch 3 out of 4 layers efficiency reaches about 98%.

  4. Dynamic phase-control of a rising sun magnetron using modulated and continuous current

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez-Gutierrez, Sulmer, E-mail: [Intel Corporation, 2111 NE 25th Ave, Hillsboro, Oregon 97214 (United States); Browning, Jim [Department of Electrical and Computer Engineering, Boise State University, Boise, Idaho 83725 (United States); Lin, Ming-Chieh [Department of Electrical and Biomedical Engineering, Hanyang University, Seoul 133-791 (Korea, Republic of); Smithe, David N. [Tech-X Corporation, 5621 Arapahoe Ave, Boulder, Colorado 80303 (United States); Watrous, Jack [Confluent Sciences, LLC, Albuquerque, New Mexico 87111 (United States)


    Phase-control of a magnetron is studied via simulation using a combination of a continuous current source and a modulated current source. The addressable, modulated current source is turned ON and OFF at the magnetron operating frequency in order to control the electron injection and the spoke phase. Prior simulation work using a 2D model of a Rising Sun magnetron showed that the use of 100% modulated current controlled the magnetron phase and allowed for dynamic phase control. In this work, the minimum fraction of modulated current source needed to achieve a phase control is studied. The current fractions (modulated versus continuous) were varied from 10% modulated current to 100% modulated current to study the effects on phase control. Dynamic phase-control, stability, and start up time of the device were studied for all these cases showing that with 10% modulated current and 90% continuous current, a phase shift of 180° can be achieved demonstrating dynamic phase control.

  5. Parabolic Dish Stirling Module (United States)

    Washom, B.


    The design, manufacture, and assembly of a commercially designed parabolic dish Stirling 25 kWe module is examined. The cost, expected performance, design uniquenesses, and future commercial potential of this module, which is regarded as the most technically advanced in the parabolic dish industry is discussed.

  6. Cosmetology. Computerized Learning Modules. (United States)

    Finnerty, Kathy, Ed.

    Intended to help reading-limited students meet course objectives, these 11 modules are based on instructional materials in cosmetology that have a higher readability equivalent. Modules cover bacteriology, chemical waving, scalp and hair massage, chemistry, hair shaping, hairstyling, chemical hair relaxing, hair coloring, skin and scalp,…

  7. Synthetic Space Vector Modulation (United States)


    Modulation RF Radio Frequency SVM Space Vector Modulation VCO Voltage Controlled Oscillator VSI Voltage Source Inverter xvi THIS PAGE...examining the literature, an NE566 voltage controlled oscillator ( VCO ) chip as seen in Figure 10 was used to design a circuit that produced the

  8. The Structure of Modules

    Institute of Scientific and Technical Information of China (English)

    陈焕艮; 佟文廷


    In this paper,we introduce two concepts:projective radical and semi-reflexive radical of a module,and establish some elementary relations among subprojective,semi-reflexive and torsion-free modules Using these properties,ws give classifications of some rings.

  9. Solar energy modulator (United States)

    Hale, R. R. (Inventor); Mcdougal, A. R.


    A module is described with a receiver having a solar energy acceptance opening and supported by a mounting ring along the optic axis of a parabolic mirror in coaxial alignment for receiving solar energy from the mirror, and a solar flux modulator plate for varying the quantity of solar energy flux received by the acceptance opening of the module. The modulator plate is characterized by an annular, plate-like body, the internal diameter of which is equal to or slightly greater than the diameter of the solar energy acceptance opening of the receiver. Slave cylinders are connected to the modulator plate for supporting the plate for axial displacement along the axis of the mirror, therby shading the opening with respect to solar energy flux reflected from the surface of the mirror to the solar energy acceptance opening.

  10. How Rapid is Rapid Prototyping? Analysis of ESPADON Programme Results

    Directory of Open Access Journals (Sweden)

    Ian D. Alston


    Full Text Available New methodologies, engineering processes, and support environments are beginning to emerge for embedded signal processing systems. The main objectives are to enable defence industry to field state-of-the-art products in less time and with lower costs, including retrofits and upgrades, based predominately on commercial off the shelf (COTS components and the model-year concept. One of the cornerstones of the new methodologies is the concept of rapid prototyping. This is the ability to rapidly and seamlessly move from functional design to the architectural design to the implementation, through automatic code generation tools, onto real-time COTS test beds. In this paper, we try to quantify the term “rapid” and provide results, the metrics, from two independent benchmarks, a radar and sonar beamforming application subset. The metrics show that the rapid prototyping process may be sixteen times faster than a conventional process.

  11. A series connection architecture for large-area organic photovoltaic modules with a 7.5% module efficiency (United States)

    Hong, Soonil; Kang, Hongkyu; Kim, Geunjin; Lee, Seongyu; Kim, Seok; Lee, Jong-Hoon; Lee, Jinho; Yi, Minjin; Kim, Junghwan; Back, Hyungcheol; Kim, Jae-Ryoung; Lee, Kwanghee


    The fabrication of organic photovoltaic modules via printing techniques has been the greatest challenge for their commercial manufacture. Current module architecture, which is based on a monolithic geometry consisting of serially interconnecting stripe-patterned subcells with finite widths, requires highly sophisticated patterning processes that significantly increase the complexity of printing production lines and cause serious reductions in module efficiency due to so-called aperture loss in series connection regions. Herein we demonstrate an innovative module structure that can simultaneously reduce both patterning processes and aperture loss. By using a charge recombination feature that occurs at contacts between electron- and hole-transport layers, we devise a series connection method that facilitates module fabrication without patterning the charge transport layers. With the successive deposition of component layers using slot-die and doctor-blade printing techniques, we achieve a high module efficiency reaching 7.5% with area of 4.15 cm2.

  12. Comparative dosimetric analysis of IMRT and VMAT (RapidArc in brain, head and neck, breast and prostate malignancies

    Directory of Open Access Journals (Sweden)

    Mirza Athar Ali


    Full Text Available Purpose: Intensity modulated radiotherapy (IMRT in the recent past has established itself as a gold standard for organs at risk (OAR sparing, target coverage and dose conformity. With the advent of a rotational treatment technology such as volumetric modulated arc therapy (VMAT, an inter-comparison is warranted to address the advantages and disadvantages of each technique. Methods: Twenty patients were selected retrospectively from our patient database. Sites included were brain, head and neck, chest wall, and prostate, with five patients for each site. For all the selected patients, both the IMRT and VMAT treatment plans were generated. Plan comparison was done in terms of OAR dose, dose homogeneity index (HI, dose conformity index (CI, target coverage, low isodose volumes, monitor units (MUs, and treatment time.Results: The VMAT showed better sparing of “parotids minus planning target volume (PTV”, spinal cord and head of femur as compared to the IMRT. The lung V40 for VMAT was lower, whereas the lung V10, contralateral lung mean dose, contralateral breast mean dose and mean body dose were lower with IMRT for chest wall cases. Both the VMAT and IMRT achieved comparable HI except for the brain site, where IMRT scored over VMAT. The CI achieved by the IMRT and VMAT were similar except for chest wall cases, whereas the VMAT achieved better dose conformity. The target coverage was comparable with both the plans. The VMAT clearly scored over IMRT in terms of average MUs (486 versus 812 respectively and average treatment time (2.54 minutes versus 5.54 minutes per treatment session. Conclusion: The VMAT (RapidArc has a potential to generate treatment plans for various anatomical sites which are comparable with the corresponding IMRT plans in terms of OAR sparing and plan quality parameters. The VMAT significantly reduces treatment time as compared to the IMRT, thus VMAT can increase the throughput of a busy radiotherapy department.

  13. Mechanical Modulation of Hybrid Graphene Microfiber Structure

    CERN Document Server

    Xu, Fei; Lu, Yan-qing


    Recently, the strain engineering of two-dimensional materials such as graphene has attracted considerable attention for its great potential in functional nanodevices. Here, we theoretically and experimentally investigate the strain manipulation of a graphene-integrated microfiber system for the first time. We analyze the influential factors of strain tuning, i.e., the geometrical parameters of the microfiber, the strain magnitude, and the probe-light wavelength. Moreover, we experimentally achieve in-line modulation as high as 30% with a moderate strain of ~5%, which is two orders of magnitude larger than previous results. The dynamic vibration response is also researched. The broadband, polarization-independent, cost-effective, strain-based modulator may find applications in low-speed modulation and strain sensing. Further, we believe that our platform may allow for all-in fiber engineering of graphene-analogue materials and provide new ideas for graphene-integrated flexible device design.

  14. Optimization of Mapping Rule of Bit-Interleaved Turbo Coded Modulation with 16QAM

    Institute of Scientific and Technical Information of China (English)

    FEI Ze-song; YANG Yu; LIU Lin-nan; KUANG Jing-ming


    Optimization of mapping rule of bit-interleaved Turbo coded modulation with 16 quadrature amplitude modulation (QAM) is investigated based on different impacts of various encoded bits sequence on Turbo decoding performance. Furthermore, bit-interleaved in-phase and quadrature phase (I-Q) Turbo coded modulation scheme are designed similarly with I-Q trellis coded modulation (TCM). Through performance evaluation and analysis, it can be seen that the novel mapping rule outperforms traditional one and the I-Q Turbo coded modulation can not achieve good performance as expected. Therefore, there is not obvious advantage in using I-Q method in bit-interleaved Turbo coded modulation.

  15. Cardiovascular disease: primary prevention, disease modulation and regenerative therapy.

    LENUS (Irish Health Repository)

    Sultan, Sherif


    Cardiovascular primary prevention and regeneration programs are the contemporary frontiers in functional metabolic vascular medicine. This novel science perspective harnesses our inherent ability to modulate the interface between specialized gene receptors and bioavailable nutrients in what is labeled as the nutrient-gene interaction. By mimicking a natural process through the conveyance of highly absorbable receptor specific nutrients, it is feasible to accelerate cell repair and optimize mitochondrial function, thereby achieving cardiovascular cure. We performed a comprehensive review of PubMed, EMBASE and Cochrane Review databases for articles relating to cardiovascular regenerative medicine, nutrigenomics and primary prevention, with the aim of harmonizing their roles within contemporary clinical practice. We searched in particular for large-scale randomized controlled trials on contemporary cardiovascular pharmacotherapies and their specific adverse effects on metabolic pathways which feature prominently in cardiovascular regenerative programs, such as nitric oxide and glucose metabolism. Scientific research on \\'cardiovascular-free\\' centenarians delineated that low sugar and low insulin are consistent findings. As we age, our insulin level increases. Those who can decelerate the rapidity of this process are prompting their cardiovascular rejuvenation. It is beginning to dawn on some clinicians that contemporary treatments are not only failing to impact on our most prevalent diseases, but they may be causing more damage than good. Primary prevention programs are crucial elements for a better outcome. Cardiovascular primary prevention and regeneration programs have enhanced clinical efficacy and quality of life and complement our conventional endovascular practice.

  16. An Analysis of High School Mathematics Achievement and English Language Arts Achievement as Predictors of Science Achievement (United States)

    Edwards, Anthony C.


    Science assessments require students to read and comprehend questions and to solve mathematical problems. The purpose of this study is to determine whether the following variables can be used to predict science achievement: English language arts achievement, mathematics achievement, socioeconomic status (SES), limited English proficiency (LEP)…

  17. GPU-based parallel clustered differential pulse code modulation (United States)

    Wu, Jiaji; Li, Wenze; Kong, Wanqiu


    Hyperspectral remote sensing technology is widely used in marine remote sensing, geological exploration, atmospheric and environmental remote sensing. Owing to the rapid development of hyperspectral remote sensing technology, resolution of hyperspectral image has got a huge boost. Thus data size of hyperspectral image is becoming larger. In order to reduce their saving and transmission cost, lossless compression for hyperspectral image has become an important research topic. In recent years, large numbers of algorithms have been proposed to reduce the redundancy between different spectra. Among of them, the most classical and expansible algorithm is the Clustered Differential Pulse Code Modulation (CDPCM) algorithm. This algorithm contains three parts: first clusters all spectral lines, then trains linear predictors for each band. Secondly, use these predictors to predict pixels, and get the residual image by subtraction between original image and predicted image. Finally, encode the residual image. However, the process of calculating predictors is timecosting. In order to improve the processing speed, we propose a parallel C-DPCM based on CUDA (Compute Unified Device Architecture) with GPU. Recently, general-purpose computing based on GPUs has been greatly developed. The capacity of GPU improves rapidly by increasing the number of processing units and storage control units. CUDA is a parallel computing platform and programming model created by NVIDIA. It gives developers direct access to the virtual instruction set and memory of the parallel computational elements in GPUs. Our core idea is to achieve the calculation of predictors in parallel. By respectively adopting global memory, shared memory and register memory, we finally get a decent speedup.

  18. Unstart Coupling Mechanism Analysis of Multiple-Modules Hypersonic Inlet

    Directory of Open Access Journals (Sweden)

    Jichao Hu


    Full Text Available The combination of multiplemodules in parallel manner is an important way to achieve the much higher thrust of scramjet engine. For the multiple-modules scramjet engine, when inlet unstarted oscillatory flow appears in a single-module engine due to high backpressure, how to interact with each module by massflow spillage, and whether inlet unstart occurs in other modules are important issues. The unstarted flowfield and coupling characteristic for a three-module hypersonic inlet caused by center module II and side module III were, conducted respectively. The results indicate that the other two hypersonic inlets are forced into unstarted flow when unstarted phenomenon appears on a single-module hypersonic inlet due to high backpressure, and the reversed flow in the isolator dominates the formation, expansion, shrinkage, and disappearance of the vortexes, and thus, it is the major factor of unstart coupling of multiple-modules hypersonic inlet. The coupling effect among multiple modules makes hypersonic inlet be more likely unstarted.

  19. On Modules Whose Singular Subgenerated Modules Are Weakly Injective

    Institute of Scientific and Technical Information of China (English)

    S. Dhompongsa; J. Sanwong; S.Plubtieng; H.Tansee


    Rings over which every singular right module is injective (briefly,right SI-rings) were introduced and investigated by Goodearl. Weakly injective modules, as a generalization of injective modules, were introduced by Jain and modules are weakly injective, which we call SwI-rings. This concept is extended to SwI-modules, i.e., modules whose singular subgenerated modules are weakly injective. Several characterizations and properties of SwI-rings and SwI-modules are obtained which generalize some earlier known results on SI-rings and weakly semisimple rings.

  20. Photovoltaic module and interlocked stack of photovoltaic modules (United States)

    Wares, Brian S.


    One embodiment relates to an arrangement of photovoltaic modules configured for transportation. The arrangement includes a plurality of photovoltaic modules, each photovoltaic module including a frame. A plurality of individual male alignment features and a plurality of individual female alignment features are included on each frame. Adjacent photovoltaic modules are interlocked by multiple individual male alignment features on a first module of the adjacent photovoltaic modules fitting into and being surrounded by corresponding individual female alignment features on a second module of the adjacent photovoltaic modules. Other embodiments, features and aspects are also disclosed.

  1. Phase modulation pseudocolor encoding ghost imaging

    Institute of Scientific and Technical Information of China (English)

    段德洋; 张路; 杜少将; 夏云杰


    We present a ghost imaging scheme that can obtain a good pseudocolor image of black-and-white objects. The essential idea is to use the multi-wavelength thermal light source and the phase modulation pseudocolor encoding technique, which overcomes the disadvantages of other methods involved the spatial filtering. Therefore, the pseudocolor ghost image achieved by this imaging scheme is better than that obtained by other methods in brightness, color, and signal-to-noise ratio.

  2. Dissertations Repository System Using Context Module

    CERN Document Server

    Hmood, Ali K; Alanazi, Hamdan O; Alnaqeib, Rami; Al-Nabhani, Yahya


    Without a doubt, the electronic learning makes education quite flexible. Nowadays, all organizations and institutions are trying to avoid Monotony and the delay and inertia. As well the universities should be improving their systems continually to achieve success. Whereas, the students need to access the dissertations in the library. In this paper we will present Dissertations Repository System Using Context Module to allow the students to benefit the dissertations which is in the library flexibly.

  3. Spatial Light Modulator for wavefront correction

    CERN Document Server

    Vyas, Akondi; Banyal, Ravinder Kumar; Prasad, B Raghavendra


    We present a liquid crystal method of correcting the phase of an aberrated wavefront using a spatial light modulator. A simple and efficient lab model has been demonstrated for wavefront correction. The crux of a wavefront correcting system in an adaptive optics system lies in the speed and the image quality that can be achieved. The speeds and the accuracy of wavefront representation using Zernike polynomials have been presented using a very fast method of computation.

  4. Essentially normal Hilbert modules and Khomology Ⅲ: Homogenous quotient modules of Hardy modules on the bidisk

    Institute of Scientific and Technical Information of China (English)

    Kun-yu GUO; Peng-hui WANG


    In this paper, we study the homogenous quotient modules of the Hardy module on the bidisk. The essential normality of the homogenous quotient modules is completely characterized. We also describe the essential spectrum for a general quotient module. The paper also considers K-homology invariant defined in the case of the homogenous quotient modules on the bidisk.

  5. A Rapid Coliform Detector Project (United States)

    National Aeronautics and Space Administration — ORBITEC, in collaboration with Lucigen, proposes a rapid genetic detector for spaceflight water systems to enable real-time detection of E-coli with minimal...

  6. Rapid Multiplex Microbial Detector Project (United States)

    National Aeronautics and Space Administration — ORBITEC, in collaboration with Lucigen, proposes a rapid nucleic acid-based detector for spaceflight water systems to enable simultaneous quantification of multiple...

  7. Rapidity correlations test stochastic hydrodynamics

    CERN Document Server

    Zin, Christopher; Moschelli, George


    We show that measurements of the rapidity dependence of transverse momentum correlations can be used to determine the characteristic time $\\tau_{\\pi}$ that dictates the rate of isotropization of the stress energy tensor, as well as the shear viscosity $\

  8. Pre-treatment verification of RapidArc® using Electronic Portal Imaging Device; Verificacao pre-tratamento de RapidArc® utilizando Dispositivo Eletronico de Imagem Porta

    Energy Technology Data Exchange (ETDEWEB)

    Lima, Marilia B.; Ferreira, Anne Caroline M.; Bittencourt, Guilherme R.; Pirani, Luis F.; Silveira, Thiago B., E-mail: [Instituto Nacional do Cancer (INCA), Rio de Janeiro, RJ (Brazil)


    The RapidArc® is a novel but widespread technique to achieve intensity modulated beams. One of the major challenges concerning this technique is the pretreatment verification process. The aim of this paper was to analyze the viability of the Electronic Portal Imaging Device (EPID) used to perform the verification of RapidArc® using the Sun Nuclear SNC Patient software enable to EPID dose conversion (EPIDose license) and compare its results with punctual dose measurements against a low volume ion chamber. There were analyze five RapidArc® planning, evaluating, separately, planar and punctual doses for each arc. For punctual measurements was used a 0,15 cm³ volume ion chamber and the planar distributions, in Calibration Units (CU), were acquired using the EPID and then converted to absolute dose in centigray through EPIDose. The predicted doses were calculated using the AAA algorithm in Eclipse treatment planning system, version 8.6. The planar comparisons, performed in SNC Patient, employed the Gamma Index tool with a 4% dose difference, 4 mm distance to agreement and 20% threshold. The evaluation of punctual dose was defined by calculating deviations between predicted and measured doses. The mean approval percentage in planar distributions was 94.8% and the average deviation in punctual dose was -1.2%. The use of EPID for RapidArc® pre-treatment verification proved to be feasible and showed good sensibility, because of its high spatial resolution. However one must consider the uncertainty of the method. (author)

  9. Foreign language comprehension achievement: insights from the cognate facilitation effect

    Directory of Open Access Journals (Sweden)

    Aina eCasaponsa


    Full Text Available Numerous studies have shown that the native language influences foreign word recognition and that this influence is modulated by the proficiency in the nonnative language. Here we explored how the degree of reliance on cross-language similarity (as measured by the cognate facilitation effect together with other domain-general cognitive factors contribute to reading comprehension achievement in a nonnative language at different stages of the learning process. We tested two groups of native speakers of Spanish learning English at elementary and intermediate levels in an academic context. A regression model approach showed that domain-general cognitive skills are good predictors of second language reading achievement independently of the level of proficiency. Critically, we found that individual differences in the degree of reliance on the native language predicted foreign language reading achievement, showing a markedly different pattern between proficiency groups. At lower levels of proficiency the cognate facilitation effect was positively related with reading achievement, while this relation became negative at intermediate levels of foreign language learning. We conclude that the link between native- and foreign-language lexical representations helps participants at initial stages of the learning process, whereas it is no longer the case at intermediate levels of proficiency, when reliance on cross-language similarity is inversely related to successful nonnative reading achievement. Thus, at intermediate levels of proficiency strong and direct mappings from the nonnative lexical forms to semantic concepts are needed to achieve good nonnative reading comprehension, in line with the premises of current models of bilingual lexico-semantic organization.

  10. Foreign language comprehension achievement: insights from the cognate facilitation effect. (United States)

    Casaponsa, Aina; Antón, Eneko; Pérez, Alejandro; Duñabeitia, Jon A


    Numerous studies have shown that the native language influences foreign word recognition and that this influence is modulated by the proficiency in the non-native language. Here we explored how the degree of reliance on cross-language similarity (as measured by the cognate facilitation effect) together with other domain-general cognitive factors contribute to reading comprehension achievement in a non-native language at different stages of the learning process. We tested two groups of native speakers of Spanish learning English at elementary and intermediate levels in an academic context. A regression model approach showed that domain-general cognitive skills are good predictors of second language reading achievement independently of the level of proficiency. Critically, we found that individual differences in the degree of reliance on the native language predicted foreign language reading achievement, showing a markedly different pattern between proficiency groups. At lower levels of proficiency the cognate facilitation effect was positively related with reading achievement, while this relation became negative at intermediate levels of foreign language learning. We conclude that the link between native- and foreign-language lexical representations helps participants at initial stages of the learning process, whereas it is no longer the case at intermediate levels of proficiency, when reliance on cross-language similarity is inversely related to successful non-native reading achievement. Thus, at intermediate levels of proficiency strong and direct mappings from the non-native lexical forms to semantic concepts are needed to achieve good non-native reading comprehension, in line with the premises of current models of bilingual lexico-semantic organization.

  11. Automated Tools for Rapid Prototyping

    Institute of Scientific and Technical Information of China (English)



    An automated environment is presented which aids the software engineers in developing data processing systems by using rapid prototyping techniques.The environment is being developed on VAX station.It can render good support to the specification of the requirements and the rapid creation of prototype.The goal,the methodology,the general structure of the environment and two sub-systems are discussed.

  12. The Strip Module

    DEFF Research Database (Denmark)

    Pedersen, Tommy


    When the behaviour of a ship in waves is to be predicted it is convenient to have a tool which includes different approaches to the problem.The aim of this project is to develop such a tool named the strip theory module. The strip theory module will consist of submodules dependent on the I....... At last a postprocessor will be included with facilities for statistical calculations and for plots and prints of the results.The project is divided into 7 tasks where the third is to be completed.This report has two aims. To give an introduction to the project of developing a strip theory module...

  13. Analytic Hilbert modules

    CERN Document Server

    Chen, Xiaoman


    The seminal 1989 work of Douglas and Paulsen on the theory of analytic Hilbert modules precipitated a number of major research efforts. This in turn led to some intriguing and valuable results, particularly in the areas of operator theory and functional analysis. With the field now beginning to blossom, the time has come to collect those results under one cover. Written by two of the most active and often-cited researchers in the field, Analytic Hilbert Modules reports on the progress made by the authors and others, including the characteristic space theory, rigidity, the equivalence problem, the Arveson modules, extension theory, and reproducing Hilbert spaces on n-dimensional complex space.

  14. Optical modulator including grapene

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang


    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  15. Microlensing modulation by binaries

    CERN Document Server

    Dubath, F; Durrer, R; Dubath, Florian; Gasparini, Maria Alice; Durrer, Ruth


    We compute the effect of the lens quadrupole on microlensing. The time dependence of the quadrupole can lead to specific modulations of the amplification signal. We study especially binary system lenses in our galaxy. The modulation is observable if the rotation period of the system is smaller than the time over which the amplification is significant and if the impact parameter of the passing light ray is sufficiently close to the Einstein radius so that the amplification is very large. Observations of this modulation can reveal important information on the quadrupole and thus on the gravitational radiation emitted by the lens.

  16. The ANTARES Optical Module

    CERN Document Server

    Amram, P; Anvar, S; Ardellier-Desages, F E; Aslanides, Elie; Aubert, Jean-Jacques; Azoulay, R; Bailey, D; Basa, S; Battaglieri, M; Bellotti, R; Benhammou, Ya; Bernard, F; Berthier, R; Bertin, V; Billault, M; Blaes, R; Bland, R W; Blondeau, F; De Botton, N R; Boulesteix, J; Brooks, B; Brunner, J; Cafagna, F; Calzas, A; Capone, A; Caponetto, L; Cârloganu, C; Carmona, E; Carr, J; Carton, P H; Cartwright, S L; Cassol, F; Cecchini, S; Ciacio, F; Circella, M; Compere, C; Cooper, S; Coyle, P; Croquette, J; Cuneo, S; Danilov, M; Van Dantzig, R; De Marzo, C; De Vita, R; Deck, P; Destelle, J J; Dispau, G; Drougou, J F; Druillole, F; Engelen, J; Feinstein, F; Festy, D; Fopma, J; Gallone, J M; Giacomelli, G; Goret, P; Gosset, L G; Gournay, J F; Heijboer, A; Hernández-Rey, J J; Herrouin, G; Hubbard, John R; Jacquet, M; De Jong, M; Karolak, M; Kooijman, P M; Kouchner, A; Kudryavtsev, V A; Lachartre, D; Lafoux, H; Lamare, P; Languillat, J C; Laubier, L; Laugier, J P; Le Guen, Y; Le Provost, H; Le Van-Suu, A; Lemoine, L; Lo Nigro, L; Lo Presti, D; Loucatos, Sotirios S; Louis, F; Lyashuk, V I; Magnier, P; Marcelin, M; Margiotta, A; Massol, A; Masullo, R; Mazéas, F; Mazeau, B; Mazure, A; McMillan, J E; Michel, J L; Migneco, E; Millot, C; Mols, P; Montanet, François; Montaruli, T; Morel, J P; Moscoso, L; Navas, S; Nezri, E; Nooren, G J L; Oberski, J; Olivetto, C; Oppelt-pohl, A; Palanque-Delabrouille, Nathalie; Payre, P; Perrin, P; Petruccetti, M; Petta, P; Piattelli, P; Poinsignon, J; Popa, V; Potheau, R; Queinec, Y; Racca, C; Raia, G; Randazzo, N; Rethore, F; Riccobene, G; Ricol, J S; Ripani, M; Roca-Blay, V; Rolin, J F; Rostovtsev, A A; Russo, G V; Sacquin, Yu; Salusti, E; Schuller, J P; Schuster, W; Soirat, J P; Suvorova, O; Spooner, N J C; Spurio, M; Stolarczyk, T; Stubert, D; Taiuti, M; Tao, Charling; Tayalati, Y; Thompson, L F; Tilav, S; Triay, R; Valente, V; Varlamov, I; Vaudaine, G; Vernin, P; De Witt-Huberts, P K A; De Wolf, E; Zakharov, V; Zavatarelli, S; De Dios-Zornoza-Gomez, Juan; Zúñiga, J


    The ANTARES collaboration is building a deep sea neutrino telescope in the Mediterranean Sea. This detector will cover a sensitive area of typically 0.1 km-squared and will be equipped with about 1000 optical modules. Each of these optical modules consists of a large area photomultiplier and its associated electronics housed in a pressure resistant glass sphere. The design of the ANTARES optical module, which is a key element of the detector, has been finalized following extensive R & D studies and is reviewed here in detail.

  17. The ANTARES optical module

    Energy Technology Data Exchange (ETDEWEB)

    Amram, P.; Anghinolfi, M.; Anvar, S.; Ardellier-Desages, F.E.; Aslanides, E.; Aubert, J.-J.; Azoulay, R.; Bailey, D.; Basa, S.; Battaglieri, M.; Bellotti, R.; Benhammou, Y.; Bernard, F.; Berthier, R.; Bertin, V.; Billault, M.; Blaes, R.; Bland, R.W.; Blondeau, F.; Botton, N. de; Boulesteix, J.; Brooks, C.B.; Brunner, J.; Cafagna, F.; Calzas, A.; Capone, A.; Caponetto, L.; Carloganu, C.; Carmona, E.; Carr, J.; Carton, P.-H.; Cartwright, S.L.; Cassol, F.; Cecchini, S.; Ciacio, F.; Circella, M.; Compere, C.; Cooper, S.; Coyle, P.; Croquette, J.; Cuneo, S.; Danilov, M.; Dantzig, R. van; De Marzo, C.; DeVita, R.; Deck, P.; Destelle, J.-J.; Dispau, G.; Drougou, J.F.; Druillole, F.; Engelen, J.; Feinstein, F.; Festy, D.; Fopma, J.; Gallone, J.-M.; Giacomelli, G.; Goret, P.; Gosset, L.; Gournay, J.-F.; Heijboer, A.; Hernandez-Rey, J.J.; Herrouin, G.; Hubbard, J.R.; Jaquet, M.; Jong, M. de; Karolak, M.; Kooijman, P.; Kouchner, A.; Kudryavtsev, V.A.; Lachartre, D.; Lafoux, H. E-mail:; Lamare, P.; Languillat, J.-C.; Laubier, L.; Laugier, J.-P.; Le Guen, Y.; Le Provost, H.; Le Van Suu, A.; Lemoine, L.; Lo Nigro, L.; Lo Presti, D.; Loucatos, S.; Louis, F.; Lyashuk, V.; Magnier, P.; Marcelin, M.; Margiotta, A.; Massol, A.; Masullo, R.; Mazeas, F.; Mazeau, B.; Mazure, A.; McMillan, J.E.; Michel, J.L.; Migneco, E.; Millot, C.; Mols, P.; Montanet, F.; Montaruli, T.; Morel, J.P.; Moscoso, L.; Musumeci, M.; Navas, S.; Nezri, E.; Nooren, G.J.; Oberski, J.; Olivetto, C.; Oppelt-Pohl, A.; Palanque-Delabrouille, N.; Papaleo, R.; Payre, P.; Perrin, P.; Petruccetti, M.; Petta, C.; Piattelli, P.; Poinsignon, J.; Potheau, R.; Queinec, Y.; Racca, C.; Raia, G.; Randazzo, N.; Rethore, F.; Riccobene, G.; Ricol, J.-S.; Ripani, M.; Roca-Blay, V.; Rolin, J.F.; Rostovstev, A.; Russo, G.V.; Sacquin, Y.; Salusti, E.; Schuller, J.-P.; Schuster, W.; Soirat, J.-P.; Souvorova, O.; Spooner, N.J.C.; Spurio, M.; Stolarczyk, T.; Stubert, D.; Taiuti, M.; Tao, C.; Tayalati, Y.; Thompson, L.F.


    The ANTARES collaboration is building a deep sea neutrino telescope in the Mediterranean Sea. This detector will cover a sensitive area of typically 0.1 km{sup 2} and will be equipped with about 1000 optical modules. Each of these optical modules consists of a large area photomultiplier and its associated electronics housed in a pressure resistant glass sphere. The design of the ANTARES optical module, which is a key element of the detector, has been finalized following extensive R and D studies and is reviewed here in detail.

  18. Intelligent spacecraft module (United States)

    Oungrinis, Konstantinos-Alketas; Liapi, Marianthi; Kelesidi, Anna; Gargalis, Leonidas; Telo, Marinela; Ntzoufras, Sotiris; Paschidi, Mariana


    The paper presents the development of an on-going research project that focuses on a human-centered design approach to habitable spacecraft modules. It focuses on the technical requirements and proposes approaches on how to achieve a spatial arrangement of the interior that addresses sufficiently the functional, physiological and psychosocial needs of the people living and working in such confined spaces that entail long-term environmental threats to human health and performance. Since the research perspective examines the issue from a qualitative point of view, it is based on establishing specific relationships between the built environment and its users, targeting people's bodily and psychological comfort as a measure toward a successful mission. This research has two basic branches, one examining the context of the system's operation and behavior and the other in the direction of identifying, experimenting and formulating the environment that successfully performs according to the desired context. The latter aspect is researched upon the construction of a scaled-model on which we run series of tests to identify the materiality, the geometry and the electronic infrastructure required. Guided by the principles of sensponsive architecture, the ISM research project explores the application of the necessary spatial arrangement and behavior for a user-centered, functional interior where the appropriate intelligent systems are based upon the existing mechanical and chemical support ones featured on space today, and especially on the ISS. The problem is set according to the characteristics presented at the Mars500 project, regarding the living quarters of six crew-members, along with their hygiene, leisure and eating areas. Transformable design techniques introduce spatial economy, adjustable zoning and increased efficiency within the interior, securing at the same time precise spatial orientation and character at any given time. The sensponsive configuration is

  19. Solar cell module. Taiyo denchi module

    Energy Technology Data Exchange (ETDEWEB)

    Nakano, Akihiko; Matsumoto, Hitoshi; Komatsu, Yasumitsu; Shirai, Sadaharu.


    In the solar cell module of this invention, such junctions as CdS/CdTe or CdS/CuInSe {sub 2} are contained as a photoelectromotive force part coexists with air in a closed space which consists of glass, metal parts and a bonding resin layer; the photoelectromotive force part is coated either with a fluorine resin or a silicone resin. The fluorine resin contains a fundamental skeleton of an alternative copolymer of fluoroolefin and a hydrocarbon-based vinyl monomer; the silicone resin has three types, i.e., addition-reacted, condensated or UV-curing type, and the released oxygen is sealed in the closed space. The resin layer which adheres the glass and the metal plate is a thermoplastic resin which is polyethylene modified by copolymerization of acid anhydride. By this, the reliability of the solar cell module was enhanced. 3 figs.

  20. Achievable rates for transmission of discrete constellations over the Gaussian MAC channe

    CERN Document Server

    Ghaffar, Rizwan; Lee, Jungwon


    In this paper we consider the achievable rate region of the Gaussian Multiple Access Channel (MAC) when suboptimal transmission schemes are employed. Focusing on the two-user MAC and assuming uncoded Pulse Amplitude Modulation (PAM), we derive a rate region that is a pentagon, and propose a strategy with which it can be achieved. We also compare the region with outer bounds and with orthogonal transmission.

  1. Nutritional Modulation of Insulin Resistance

    Directory of Open Access Journals (Sweden)

    Martin O. Weickert


    Full Text Available Insulin resistance has been proposed as the strongest single predictor for the development of Type 2 Diabetes (T2DM. Chronic oversupply of energy from food, together with inadequate physical activity, have been recognized as the most relevant factors leading to overweight, abdominal adiposity, insulin resistance, and finally T2DM. Conversely, energy reduced diets almost invariably to facilitate weight loss and reduce abdominal fat mass and insulin resistance. However, sustained weight loss is generally difficult to achieve, and distinct metabolic characteristics in patients with T2DM further compromise success. Therefore, investigating the effects of modulating the macronutrient composition of isoenergetic diets is an interesting concept that may lead to additional important insights. Metabolic effects of various different dietary concepts and strategies have been claimed, but results from randomized controlled studies and particularly from longer-term-controlled interventions in humans are often lacking. However, some of these concepts are supported by recent research, at least in animal models and short-term studies in humans. This paper provides an update of the current literature regarding the role of nutrition in the modulation of insulin resistance, which includes the discussion of weight-loss-independent metabolic effects of commonly used dietary concepts.

  2. Case studies in intelligent computing achievements and trends

    CERN Document Server

    Issac, Biju


    Although the field of intelligent systems has grown rapidly in recent years, there has been a need for a book that supplies a timely and accessible understanding of this important technology. Filling this need, Case Studies in Intelligent Computing: Achievements and Trends provides an up-to-date introduction to intelligent systems.This edited book captures the state of the art in intelligent computing research through case studies that examine recent developments, developmental tools, programming, and approaches related to artificial intelligence (AI). The case studies illustrate successful ma

  3. Plan Quality and Treatment Efficiency for Radiosurgery to Multiple Brain Metastases: Non-Coplanar RapidArc vs Gamma Knife

    Directory of Open Access Journals (Sweden)

    Haisong eLiu


    Full Text Available Objectives: This study compares the dosimetry and efficiency of two modern radiosurgery (SRS modalities for multiple brain metastases (Gamma Knife and LINAC-based RapidArc/volumetric modulated arc therapy, with a special focus on the comparison of low dose spread.Methods: Six patients with three or four small brain metastases were used in this study. The size of targets varied from 0.1 ~ 10.5 cc. SRS doses were prescribed according to size of lesions. SRS plans were made using both Gamma Knife® Perfexion and a single-isocenter, multiple non-coplanar RapidArc®. Dosimetric parameters analyzed included RTOG conformity index (CI, gradient index (GI, 12 Gy isodose volume (V12Gy for each target, and the dose spread (Dspread for each plan. Dspread reflects SRS plan’s capability of confining radiation to within the local vicinity of the lesion and to not spread out to the surrounding normal brain tissues. Each plan has a dose (Dspread, such that once dose decreases below Dspread (on total tissue DVH, isodose volume starts increasing dramatically. Dspread is defined as that dose when volume increase first exceeds 20 cc per 0.1 Gy dose decrease. Results: RapidArc SRS has smaller CI (1.19 ±0.14 vs. 1.50 ± 0.16, p<0.001 and larger GI (4.77 ± 1.49 vs. 3.65 ± 0.98, p <0.01. V12Gy results were comparable (2.73 ± 1.38 cc vs. 3.06 ± 2.20 cc, p = 0.58. Moderate to lower dose spread, V6, V4.5, and V3, were also equivalent. Gamma Knife plans achieved better very low dose spread (≤3 Gy and also had slightly smaller Dspread, 1.9 Gy vs 2.5 Gy. Total treatment time for Gamma Knife is estimated between 60~100 min. Gamma Knife treatments are between 3~5 times longer compared to RapidArc treatment techniques.Conclusion: Dosimetric parameters reflecting prescription dose conformality (CI, dose fall off (GI, radiation necrosis indicator (V12Gy, and dose spread (Dspread were compared between Gamma Knife SRS and RapidArc SRS for multi-mets. RapidArc plans have



  5. Module bay with directed flow (United States)

    Torczynski, John R.


    A module bay requires less cleanroom airflow. A shaped gas inlet passage can allow cleanroom air into the module bay with flow velocity preferentially directed toward contaminant rich portions of a processing module in the module bay. Preferential gas flow direction can more efficiently purge contaminants from appropriate portions of the module bay, allowing a reduced cleanroom air flow rate for contaminant removal. A shelf extending from an air inlet slit in one wall of a module bay can direct air flowing therethrough toward contaminant-rich portions of the module bay, such as a junction between a lid and base of a processing module.

  6. Recent Achievement in Gene Cloning and Functional Genomics in Soybean

    Directory of Open Access Journals (Sweden)

    Zhengjun Xia


    Full Text Available Soybean is a model plant for photoperiodism as well as for symbiotic nitrogen fixation. However, a rather low efficiency in soybean transformation hampers functional analysis of genes isolated from soybean. In comparison, rapid development and progress in flowering time and photoperiodic response have been achieved in Arabidopsis and rice. As the soybean genomic information has been released since 2008, gene cloning and functional genomic studies have been revived as indicated by successfully characterizing genes involved in maturity and nematode resistance. Here, we review some major achievements in the cloning of some important genes and some specific features at genetic or genomic levels revealed by the analysis of functional genomics of soybean.

  7. Enriching the Hierarchical Model of Achievement Motivation: Autonomous and Controlling Reasons Underlying Achievement Goals (United States)

    Michou, Aikaterini; Vansteenkiste, Maarten; Mouratidis, Athanasios; Lens, Willy


    Background: The hierarchical model of achievement motivation presumes that achievement goals channel the achievement motives of need for achievement and fear of failure towards motivational outcomes. Yet, less is known whether autonomous and controlling reasons underlying the pursuit of achievement goals can serve as additional pathways between…

  8. A dosimetric phantom study of dose accuracy and build-up effects using IMRT and RapidArc in stereotactic irradiation of lung tumours

    Directory of Open Access Journals (Sweden)

    Seppala Jan


    Full Text Available Abstract Background and purpose Stereotactic lung radiotherapy (SLRT has emerged as a curative treatment for medically inoperable patients with early-stage non-small cell lung cancer (NSCLC and the use of intensity-modulated radiotherapy (IMRT and volumetric modulated arc treatments (VMAT have been proposed as the best practical approaches for the delivery of SLRT. However, a large number of narrow field shapes are needed in the dose delivery of intensity-modulated techniques and the probability of underdosing the tumour periphery increases as the effective field size is decreased. The purpose of this study was to evaluate small lung tumour doses irradiated by intensity-modulated techniques to understand the risk for dose calculation errors in precision radiotherapy such as SLRT. Materials and methods The study was executed with two heterogeneous phantoms with targets of Ø1.5 and Ø4.0 cm. Dose distributions in the simulated tumours delivered by small sliding window apertures (SWAs, IMRT and RapidArc treatment plans were measured with radiochromic film. Calculation algorithms of pencil beam convolution (PBC and anisotropic analytic algorithm (AAA were used to calculate the corresponding dose distributions. Results Peripheral doses of the tumours were decreased as SWA decreased, which was not modelled by the calculation algorithms. The smallest SWA studied was 2 mm, which reduced the 90% isodose line width by 4.2 mm with the Ø4.0 cm tumour as compared to open field irradiation. PBC was not able to predict the dose accurately as the gamma evaluation failed to meet the criteria of ±3%/±1 mm on average in 61% of the defined volume with the smaller tumour. With AAA the corresponding value was 16%. The dosimetric inaccuracy of AAA was within ±3% with the optimized treatment plans of IMRT and RapidArc. The exception was the clinical RapidArc plan with dose overestimation of 4%. Conclusions Overall, the peripheral doses of the simulated

  9. Revisiting static modulation in pyramid wavefront sensing (United States)

    Marafatto, L.; Ragazzoni, R.; Vassallo, D.; Bergomi, M.; Biondi, F.; Farinato, J.; Greggio, D.; Magrin, D.; Viotto, V.


    The Pyramid Sensor (PS) is based on the Focault knife-edge test, yielding then, in geometrical approximation, only the sign of the wavefront slope. To provide linear measurements of the wavefront slopes the PS relies on a technique known as modulation, which also plays a central role to improve the linear range of the pyramid WFS, very small in the nonmodulated case. In the main PS using modulation so far, this task is achieved by moving optical components in the WFS, increasing the complexity of the system. An attractive idea to simplify the optical and mechanical design of a pyramid WFS is to work without any dynamic modulation. This concept was only merely described and functionally tested in the framework of MAD, and subsequently, with a holographic diffuser. The latter produce a sort of random distribution of the light coming out from the pupil plane, leading to sort of inefficient modulation, as most of the rays are focused in the central region of the light diffused by such device. The bi-dimensional original grating is, in contrast, producing a well defined deterministic distribution of the light onto a specifically shaped pattern. A crude option has been already discussed as a possibility, and it is here generalized to holographic plates leading to various distribution of lights, including a circle whose diameter would match the required modulation pattern, or more cost effective approaches like the one of a square pattern. These holographic diffusers would exhibit also zero-th and high order patterns and the actual size of the equivalent modulation would be linearly wavelength dependent, leading to colour effects that requires a careful handling in order to properly choose the right amount of equivalent modulation.

  10. Isothermal Containment Module (United States)


    Isothermal Containment Modules are the temperature-controlling carrier that BioServe built to carry Commercial Generic Bioprocessing Apparatus (CGBA) and in the future, Space Automated Bioproduct Lab (SABL) to the International Space Station.

  11. A photovoltaic module

    DEFF Research Database (Denmark)


    The present invention relates to a photovoltaic module comprising a carrier substrate, said carrier substrate carrying a purely printed structure comprising printed positive and negative module terminals, a plurality of printed photovoltaic cell units each comprising one or more printed...... photovoltaic cells, wherein the plurality of printed photovoltaic cell units are electrically connected in series between the positive and the negative module terminals such that any two neighbouring photovoltaic cell units are electrically connected by a printed interconnecting electrical conductor....... The carrier substrate comprises a foil and the total thickness of the photovoltaic module is below 500 [mu]m. Moreover, the nominal voltage level between the positive and the negative terminals is at least 5 kV DC....

  12. Ultrasound Modulated Bioluminescence Tomography

    CERN Document Server

    Bal, Guillaume


    We propose a method to reconstruct the density of a luminescent source in a highly-scattering medium from ultrasound modulated optical measurements. Our approach is based on the solution to a hybrid inverse source problem for the diffusion equation.

  13. GREET Pretreatment Module

    Energy Technology Data Exchange (ETDEWEB)

    Adom, Felix K.; Dunn, Jennifer B.; Han, Jeongwoo


    A wide range of biofuels and biochemicals can be produced from biomass via different pretreatment technologies that yield sugars. This report documents the material and energy flows that occur when fermentable sugars from four lignocellulosic feedstocks (corn stover, miscanthus, switchgrass, and poplar) are produced via dilute acid pretreatment and ammonia fiber expansion. These flows are documented for inclusion in the pretreatment module of the Greenhouses Gases, Regulated Emissions, and Energy Use in Transportation (GREET) model. Process simulations of each pretreatment technology were developed in Aspen Plus. Material and energy consumption data from Aspen Plus were then compiled in the GREET pretreatment module. The module estimates the cradle-to-gate fossil energy consumption (FEC) and greenhouse gas (GHG) emissions associated with producing fermentable sugars. This report documents the data and methodology used to develop this module and the cradle-to-gate FEC and GHG emissions that result from producing fermentable sugars.

  14. Top Local Cohomology Modules

    Institute of Scientific and Technical Information of China (English)

    Mohammad T. Dibaei; Siamak Yassemi


    For a finitely generated module M over a commutative Noetherian local ring (R, m), it is shown that there exist only a finite number of non-isomorphic top localeohomology modules Hdim(M) (M) for all ideals a of RIt is also shown that for a giveninteger r ≥ 0, if Hra(R/p) is zero for all p in Supp(M), then Hia(M)=0 for all I ≥ r.

  15. Groups, rings, modules

    CERN Document Server

    Auslander, Maurice


    This classic monograph is geared toward advanced undergraduates and graduate students. The treatment presupposes some familiarity with sets, groups, rings, and vector spaces. The four-part approach begins with examinations of sets and maps, monoids and groups, categories, and rings. The second part explores unique factorization domains, general module theory, semisimple rings and modules, and Artinian rings. Part three's topics include localization and tensor products, principal ideal domains, and applications of fundamental theorem. The fourth and final part covers algebraic field extensions

  16. Rapid adiabatic passage without level crossing

    CERN Document Server

    Rangelov, A A; Shore, B W


    We present a method for achieving complete population transfer in a two-state quantum system via adiabatic time evolution in which, contrary to conventional rapid adiabatic passage produced by chirped pulses, there occurs no crossing of diabatic energy curves: there is no sign change of the detuning. Instead, we use structured pulses, in which, in addition to satisfying conditions for adiabatic evolution, there occurs a sign change of the Rabi frequency when the detuning is zero. We present simulations that offer simple geometrical interpretation of the two-dimensional motion of the Bloch vector for this system, illustrating how both complete population inversion and complete population return occur for different choices of structured pulses.

  17. Rapid virtual stenting for intracranial aneurysms (United States)

    Zhao, Liang; Chen, Danyang; Chen, Zihe; Wang, Xiangyu; Paliwal, Nikhil; Xiang, Jianping; Meng, Hui; Corso, Jason J.; Xu, Jinhui


    The rupture of Intracranial Aneurysms is the most severe form of stroke with high rates of mortality and disability. One of its primary treatments is to use stent or Flow Diverter to divert the blood flow away from the IA in a minimal invasive manner. To optimize such treatments, it is desirable to provide an automatic tool for virtual stenting before its actual implantation. In this paper, we propose a novel method, called ball-sweeping, for rapid virtual stenting. Our method sweeps a maximum inscribed sphere through the aneurysmal region of the vessel and directly generates a stent surface touching the vessel wall without needing to iteratively grow a deformable stent surface. Our resulting stent mesh has guaranteed smoothness and variable pore density to achieve an enhanced occlusion performance. Comparing to existing methods, our technique is computationally much more efficient.

  18. Absolutely Indecomposable Modules

    CERN Document Server

    Göbel, Rüdiger


    A module is called absolutely indecomposable if it is directly indecomposable in every generic extension of the universe. We want to show the existence of large abelian groups that are absolutely indecomposable. This will follow from a more general result about R-modules over a large class of commutative rings R with endomorphism ring R which remains the same when passing to a generic extension of the universe. It turns out that `large' in this context has the precise meaning, namely being smaller then the first omega-Erdos cardinal defined below. We will first apply result on large rigid trees with a similar property established by Shelah in 1982, and will prove the existence of related ` R_omega-modules' (R-modules with countably many distinguished submodules) and finally pass to R-modules. The passage through R_omega-modules has the great advantage that the proofs become very transparent essentially using a few `linear algebra' arguments accessible also for graduate students. The result gives a new constru...

  19. Photovoltaic module reliability workshop

    Energy Technology Data Exchange (ETDEWEB)

    Mrig, L. (ed.)


    The paper and presentations compiled in this volume form the Proceedings of the fourth in a series of Workshops sponsored by Solar Energy Research Institute (SERI/DOE) under the general theme of photovoltaic module reliability during the period 1986--1990. The reliability Photo Voltaic (PV) modules/systems is exceedingly important along with the initial cost and efficiency of modules if the PV technology has to make a major impact in the power generation market, and for it to compete with the conventional electricity producing technologies. The reliability of photovoltaic modules has progressed significantly in the last few years as evidenced by warranties available on commercial modules of as long as 12 years. However, there is still need for substantial research and testing required to improve module field reliability to levels of 30 years or more. Several small groups of researchers are involved in this research, development, and monitoring activity around the world. In the US, PV manufacturers, DOE laboratories, electric utilities and others are engaged in the photovoltaic reliability research and testing. This group of researchers and others interested in this field were brought together under SERI/DOE sponsorship to exchange the technical knowledge and field experience as related to current information in this important field. The papers presented here reflect this effort.

  20. Yetter-Drinfel‘d Module and Convolution Module

    Institute of Scientific and Technical Information of China (English)

    张良云; 王栓宏


    In this paper,we first give a sufficent and necessary condition for a Hopf algebra to be a Yetter-Drinfel'd module,and prove that the finite dual of a Yetter-Drinfel'd module is still a Yetter-Drinfel'd module,Finally,we introduce a concept of convolution module.

  1. Analogue and digital linear modulation techniques for mobile satellite (United States)

    Whitmarsh, W. J.; Bateman, A.; Mcgeehan, J. P.


    The choice of modulation format for a mobile satellite service is complex. The subjective performance is summarized of candidate schemes and voice coder technologies. It is shown that good performance can be achieved with both analogue and digital voice systems, although the analogue system gives superior performance in fading. The results highlight the need for flexibility in the choice of signaling format. Linear transceiver technology capable of using many forms of narrowband modulation is described.


    Relvas, Carlos; Reis, Joana; Potes, José Alberto Caeiro; Fonseca, Fernando Manuel Ferreira; Simões, José Antonio Oliveira


    This study, aimed the development of a methodology for rapid manufacture of orthopedic implants simultaneously with the surgical intervention, considering two potential applications in the fields of orthopedics: the manufacture of anatomically adapted implants and implants for bone loss replacement. This work innovation consists on the capitation of the in situ geometry of the implant by direct capture of the shape using an elastomeric material (polyvinylsiloxane) which allows fine detail and great accuracy of the geometry. After scanning the elastomeric specimen, the implant is obtained by machining using a CNC milling machine programmed with a dedicated CAD/CAM system. After sterilization, the implant is able to be placed on the patient. The concept was developed using low cost technology and commercially available. The system has been tested in an in vivo hip arthroplasty performed on a sheep. The time increase of surgery was 80 minutes being 40 minutes the time of implant manufacturing. The system developed has been tested and the goals defined of the study achieved enabling the rapid manufacture of an implant in a time period compatible with the surgery time. PMID:27004181

  3. Rapid response manufacturing (RRM). Final CRADA report

    Energy Technology Data Exchange (ETDEWEB)

    Cain, W.D. [Lockheed Martin Energy Systems, Inc., Oak Ridge, TN (United States); Waddell, W.L. [National Centers for Manufacturing Sciences, Ann Arbor, MI (United States)


    US industry is fighting to maintain its competitive edge in the global market place. Markets fluctuate rapidly. Companies have to be able to respond quickly with improved, high quality, cost efficient products. Because companies and their suppliers are geographically distributed, rapid product realization is dependent on the development of a secure integrated concurrent engineering environment operating across multiple business entities. The way products are developed and brought to market can be improved and made more efficient through the proper incorporation of emerging technologies implemented in a secure environment. This documents the work done under this CRADA to develop capabilities, which permit the effective application, incorporation, and use of advanced technologies in a secure environment to facilitate the product realization process. Lockheed Martin Energy Systems (LMES), through a CRADA with the National Center for Manufacturing Sciences (NCMS), worked within a consortium of major industrial firms--Ford, General Motors, Texas Instruments, United Technologies, and Eastman Kodak--and several small suppliers of advanced manufacturing technology--MacNeal-Schwendler Corp., Teknowledge Corp., Cimplex Corp., Concentra, Spatial Technology, and Structural Dynamics Research Corp. (SDRC)--to create infrastructure to support the development and implementation of secure engineering environments for Rapid Response Manufacturing. The major accomplishment achieved under this CRADA was the demonstration of a prototypical implementation of a broad-based generic framework for automating and integrating the design-to-manufacturing activities associated with machined parts in a secure NWC compliant environment. Specifically, methods needed to permit the effective application, incorporation, and use of advanced technologies in a secure environment to facilitate the product realization process were developed and demonstrated. An important aspect of this demonstration was

  4. Identification of time-varying dynamics of the human triceps surae stretch reflex. I. Rapid isometric contraction. (United States)

    Kirsch, R F; Kearney, R E; MacNeil, J B


    We have examined the time variations of stretch reflex dynamics throughout rapid voluntary changes in the isometric contraction level of the human triceps surae muscles. This was achieved by superimposing a small stochastic displacement upon many such changing contractions and then identifying the time-varying relationship between the perturbation and the evoked electromyograms (EMGs). An "ensemble" time-varying system identification technique was used to estimate these input-output dynamics as a set of impulse response functions, one for each time before, during, and after the change in contraction level, with a temporal resolution equal to the data acquisition rate. Three main findings resulted. First, stretch reflex gain (relating joint velocity to EMG) was significantly modulated during changes in voluntary contraction level, increasing as the subject contracted the muscles and decreasing as the subject relaxed. Second, stretch reflex dynamics did not change with contraction level, even when its gain varied substantially. Third, the time course of the gain changes closely followed the level of the EMG, even though the subjects used rather different activation and deactivation patterns. These results suggest that, for the behavior studied (i.e., rapid changes in isometric contraction level), stretch reflex gain and motoneuron pool activation level were controlled by a common descending command rather than being independently specified.

  5. Universal enveloping crossed module of Leibniz crossed modules and representations (United States)

    Casado, Rafael F.; García-Martínez, Xabier; Ladra, Manuel


    The universal enveloping algebra functor UL: Lb → Alg, defined by Loday and Pirashvili [1], is extended to crossed modules. Then we construct an isomorphism between the category of representations of a Leibniz crossed module and the category of left modules over its universal enveloping crossed module of algebras. Note that the procedure followed in the proof for the Lie case cannot be adapted, since the actor in the category of Leibniz crossed modules does not always exist.

  6. Attractive faces temporally modulate visual attention

    Directory of Open Access Journals (Sweden)

    Koyo eNakamura


    Full Text Available Facial attractiveness is an important biological and social signal on social interaction. Recent research has demonstrated that an attractive face captures greater spatial attention than an unattractive face does. Little is known, however, about the temporal characteristics of visual attention for facial attractiveness. In this study, we investigated the temporal modulation of visual attention induced by facial attractiveness by using a rapid serial visual presentation (RSVP. Fourteen male faces and two female faces were successively presented for 160 ms respectively, and participants were asked to identify two female faces embedded among a series of multiple male distractor faces. Identification of a second female target (T2 was impaired when a first target (T1 was attractive compared to neutral or unattractive faces, at 320 ms SOA; identification was improved when T1 was attractive compared to unattractive faces at 640 ms SOA. These findings suggest that the spontaneous appraisal of facial attractiveness modulates temporal attention.

  7. Electron butterfly distribution modulation by magnetosonic waves (United States)

    Maldonado, Armando A.; Chen, Lunjin; Claudepierre, Seth G.; Bortnik, Jacob; Thorne, Richard M.; Spence, Harlan


    The butterfly pitch angle distribution is observed as a dip in an otherwise normal distribution of electrons centered about αeq=90°. During storm times, the formation of the butterfly distribution on the nightside magnetosphere has been attributed to L shell splitting combined with magnetopause shadowing and strong positive radial flux gradients. It has been shown that this distribution can be caused by combined chorus and magnetosonic wave scattering where the two waves work together but at different local times. Presented in our study is an event on 21 August 2013, using Van Allen Probe measurements, where a butterfly distribution formation is modulated by local magnetosonic coherent magnetosonic waves intensity. Transition from normal to butterfly distributions coincides with rising magnetosonic wave intensity while an opposite transition occurs when wave intensity diminishes. We propose that bounce resonance with waves is the underlying process responsible for such rapid modulation, which is confirmed by our test particle simulation.

  8. Enhancement of ammonia gas detection by integrating wavelength-modulated spectra across the line 992.69 cm-1 (United States)

    Dallah, Mohammad; Salloum, Akil


    A rapid tunable diode laser (TDL) absorption sensor was developed for real-time measurements of ammonia concentration by using wavelength modulation spectroscopy (WMS) at 992.698 cm-1 of the ν2 vibrational band. This line has patterns free from interference with other species in the atmosphere, and can be used for open-path detection. The 1f signal was used to normalize the 2f signal thereby eliminating the need for calibration and explaining the laser transmission variations. Using WMS with a large modulation depth and integrating the absolute value of the resulting spectra increased the limit of detection (LOD) of the sensor by a factor of seven, compared with the LOD achieved by using the maximum value of the WMS 2f signal. Furthermore, an increase by a factor of 25 compared with the direct absorption spectroscopy was achieved, which allowed obtaining LOD ∼ 1 ppb with a resolution time of <2 s for the detection of NH3 in the atmosphere using a short-path cell (a 60-cm absorption cell with four passes).

  9. Biomass Rapid Analysis Network (BRAN)

    Energy Technology Data Exchange (ETDEWEB)


    Helping the emerging biotechnology industry develop new tools and methods for real-time analysis of biomass feedstocks, process intermediates and The Biomass Rapid Analysis Network is designed to fast track the development of modern tools and methods for biomass analysis to accelerate the development of the emerging industry. The network will be led by industry and organized and coordinated through the National Renewable Energy Lab. The network will provide training and other activities of interest to BRAN members. BRAN members will share the cost and work of rapid analysis method development, validate the new methods, and work together to develop the training for the future biomass conversion workforce.

  10. Modulating the Neutron Flux from a Mirror Neutron Source

    Energy Technology Data Exchange (ETDEWEB)

    Ryutov, D D


    A 14-MeV neutron source based on a Gas-Dynamic Trap will provide a high flux of 14 MeV neutrons for fusion materials and sub-component testing. In addition to its main goal, the source has potential applications in condensed matter physics and biophysics. In this report, the author considers adding one more capability to the GDT-based neutron source, the modulation of the neutron flux with a desired frequency. The modulation may be an enabling tool for the assessment of the role of non-steady-state effects in fusion devices as well as for high-precision, low-signal basic science experiments favoring the use of the synchronous detection technique. A conclusion is drawn that modulation frequency of up to 1 kHz and modulation amplitude of a few percent is achievable. Limitations on the amplitude of modulations at higher frequencies are discussed.

  11. Module network inference from a cancer gene expression data set identifies microRNA regulated modules.

    Directory of Open Access Journals (Sweden)

    Eric Bonnet

    Full Text Available BACKGROUND: MicroRNAs (miRNAs are small RNAs that recognize and regulate mRNA target genes. Multiple lines of evidence indicate that they are key regulators of numerous critical functions in development and disease, including cancer. However, defining the place and function of miRNAs in complex regulatory networks is not straightforward. Systems approaches, like the inference of a module network from expression data, can help to achieve this goal. METHODOLOGY/PRINCIPAL FINDINGS: During the last decade, much progress has been made in the development of robust and powerful module network inference algorithms. In this study, we analyze and assess experimentally a module network inferred from both miRNA and mRNA expression data, using our recently developed module network inference algorithm based on probabilistic optimization techniques. We show that several miRNAs are predicted as statistically significant regulators for various modules of tightly co-expressed genes. A detailed analysis of three of those modules demonstrates that the specific assignment of miRNAs is functionally coherent and supported by literature. We further designed a set of experiments to test the assignment of miR-200a as the top regulator of a small module of nine genes. The results strongly suggest that miR-200a is regulating the module genes via the transcription factor ZEB1. Interestingly, this module is most likely involved in epithelial homeostasis and its dysregulation might contribute to the malignant process in cancer cells. CONCLUSIONS/SIGNIFICANCE: Our results show that a robust module network analysis of expression data can provide novel insights of miRNA function in important cellular processes. Such a computational approach, starting from expression data alone, can be helpful in the process of identifying the function of miRNAs by suggesting modules of co-expressed genes in which they play a regulatory role. As shown in this study, those modules can then be

  12. Peripheral sounds rapidly activate visual cortex: evidence from electrocorticography. (United States)

    Brang, David; Towle, Vernon L; Suzuki, Satoru; Hillyard, Steven A; Di Tusa, Senneca; Dai, Zhongtian; Tao, James; Wu, Shasha; Grabowecky, Marcia


    Neurophysiological studies with animals suggest that sounds modulate activity in primary visual cortex in the presence of concurrent visual stimulation. Noninvasive neuroimaging studies in humans have similarly shown that sounds modulate activity in visual areas even in the absence of visual stimuli or visual task demands. However, the spatial and temporal limitations of these noninvasive methods prevent the determination of how rapidly sounds activate early visual cortex and what information about the sounds is relayed there. Using spatially and temporally precise measures of local synaptic activity acquired from depth electrodes in humans, we demonstrate that peripherally presented sounds evoke activity in the anterior portion of the contralateral, but not ipsilateral, calcarine sulcus within 28 ms of sound onset. These results suggest that auditory stimuli rapidly evoke spatially specific activity in visual cortex even in the absence of concurrent visual stimulation or visual task demands. This rapid auditory-evoked activation of primary visual cortex is likely to be mediated by subcortical pathways or direct cortical projections from auditory to visual areas.

  13. Characterizations of Graded Distributive Modules

    Institute of Scientific and Technical Information of China (English)

    Qinghua Chen; Chang'an Li


    In this paper, we give some characterizations of graded distributive modules, prove some interesting results between graded rings (modules) and lattices under finiteness conditions, and investigate the direct sum of graded distributive modules in terms of orders of graded submodules and homomorphisms of graded factor modules.

  14. Capacity Estimation and Near-Capacity Achieving Techniques for Digitally Modulated Communication Systems

    DEFF Research Database (Denmark)

    Yankov, Metodi Plamenov

    investigation will include linear interference channels of high dimensionality (such as multiple-input multiple-output), and the non-linear optical fiber channel, which has been gathering more and more attention from the information theory community in recent years. In both cases novel CCC estimates and lower...

  15. Nanophotonic Modulator with Bismuth Ferrite as Low-loss Switchable Material

    DEFF Research Database (Denmark)

    Babicheva, Viktoriia; Zhukovsky, Sergei; Lavrinenko, Andrei


    We propose a nanophotonic waveguide modulator with bismuth ferrite as a tunable material. Due to near-zero losses in bismuth ferrite, modulation with up to 20 dB/μm extinction ratio and 12 μm propagation length is achieved.......We propose a nanophotonic waveguide modulator with bismuth ferrite as a tunable material. Due to near-zero losses in bismuth ferrite, modulation with up to 20 dB/μm extinction ratio and 12 μm propagation length is achieved....

  16. Wireless Local Area Network Adaptive Modulation and Coding Technology Research

    Institute of Scientific and Technical Information of China (English)

    SUN Zeng-you; SUN Xiao-fan


      Expound the existing modulation mode of the present wireless local area network. Directing at the problem that when single modulation method conveys data with high speed in the frequency selective fading channel, the system throughput will be declined and the efficiency of the spectrum will be lowered . Put forward the scheme that the OFDM sub-carrier will use differ⁃ent modulation modes after dynamic groups by amplitude frequency response. Simulation results show that the scheme will lower the complexity of the system achievement, and can get a higher spectrum efficiency.

  17. The biometric-based module of smart grid system (United States)

    Engel, E.; Kovalev, I. V.; Ermoshkina, A.


    Within Smart Grid concept the flexible biometric-based module base on Principal Component Analysis (PCA) and selective Neural Network is developed. The formation of the selective Neural Network the biometric-based module uses the method which includes three main stages: preliminary processing of the image, face localization and face recognition. Experiments on the Yale face database show that (i) selective Neural Network exhibits promising classification capability for face detection, recognition problems; and (ii) the proposed biometric-based module achieves near real-time face detection, recognition speed and the competitive performance, as compared to some existing subspaces-based methods.

  18. Three-axis atomic magnetometer based on spin precession modulation

    Energy Technology Data Exchange (ETDEWEB)

    Huang, H. C.; Dong, H. F., E-mail:; Hu, X. Y.; Chen, L.; Gao, Y. [School of Instrumentation Science and Opto-Electronics Engineering, Beihang University, Beijing 100191 (China)


    We demonstrate a three-axis atomic magnetometer with one intensity-modulated pump beam and one orthogonal probe beam. The main field component is measured using the resonance of the pumping light, while the transverse field components are measured simultaneously using the optical rotation of the probe beam modulated by the spin precession. It is an all-optical magnetometer without using any modulation field or radio frequency field. Magnetic field sensitivity of 0.8 pT/Hz{sup 1∕2} is achieved under a bias field of 2 μT.

  19. Highly Functional TNTs with Superb Photocatalytic, Optical, and Electronic Performance Achieving Record PV Efficiency of 10.1% for 1D-Based DSSCs. (United States)

    Qadir, Muhammad Bilal; Li, Yuewen; Sahito, Iftikhar Ali; Arbab, Alvira Ayoub; Sun, Kyung Chul; Mengal, Naveed; Memon, Anam Ali; Jeong, Sung Hoon


    Different nanostructures of TiO2 play an important role in the photocatalytic and photoelectronic applications. TiO2 nanotubes (TNTs) have received increasing attention for these applications due to their unique physicochemical properties. Focusing on highly functional TNTs (HF-TNTs) for photocatalytic and photoelectronic applications, this study describes the facile hydrothermal synthesis of HF-TNTs by using commercial and cheaper materials for cost-effective manufacturing. To prove the functionality and applicability, these TNTs are used as scattering structure in dye-sensitized solar cells (DSSCs). Photocatalytic, optical, Brunauer-Emmett-Teller (BET), electrochemical impedance spectrum, incident-photon-to-current efficiency, and intensity-modulated photocurrent spectroscopy/intensity-modulated photovoltage spectroscopy characterizations are proving the functionality of HF-TNTs for DSSCs. HF-TNTs show 50% higher photocatalytic degradation rate and also 68% higher dye loading ability than conventional TNTs (C-TNTs). The DSSCs having HF-TNT and its composite-based multifunctional overlayer show effective light absorption, outstanding light scattering, lower interfacial resistance, longer electron lifetime, rapid electron transfer, and improved diffusion length, and consequently, J SC , quantum efficiency, and record photoconversion efficiency of 10.1% using commercial N-719 dye is achieved, for 1D-based DSSCs. These new and highly functional TNTs will be a concrete fundamental background toward the development of more functional applications in fuel cells, dye-sensitized solar cells, Li-ion batteries, photocatalysis process, ion-exchange/adsorption process, and photoelectrochemical devices.

  20. Three brief assessments of math achievement. (United States)

    Steiner, Eric T; Ashcraft, Mark H


    Because of wide disparities in college students' math knowledge-that is, their math achievement-studies of cognitive processing in math tasks also need to assess their individual level of math achievement. For many research settings, however, using existing math achievement tests is either too costly or too time consuming. To solve this dilemma, we present three brief tests of math achievement here, two drawn from the Wide Range Achievement Test and one composed of noncopyrighted items. All three correlated substantially with the full achievement test and with math anxiety, our original focus, and all show acceptable to excellent reliability. When lengthy testing is not feasible, one of these brief tests can be substituted.

  1. Mitochondrial Calcium Uptake Modulates Synaptic Vesicle Endocytosis in Central Nerve Terminals. (United States)

    Marland, Jamie Roslin Keynes; Hasel, Philip; Bonnycastle, Katherine; Cousin, Michael Alan


    Presynaptic calcium influx triggers synaptic vesicle (SV) exocytosis and modulates subsequent SV endocytosis. A number of calcium clearance mechanisms are present in central nerve terminals that regulate intracellular free calcium levels both during and after stimulation. During action potential stimulation, mitochondria rapidly accumulate presynaptic calcium via the mitochondrial calcium uniporter (MCU). The role of mitochondrial calcium uptake in modulating SV recycling has been debated extensively, but a definitive conclusion has not been achieved. To directly address this question, we manipulated the expression of the MCU channel subunit in primary cultures of neurons expressing a genetically encoded reporter of SV turnover. Knockdown of MCU resulted in ablation of activity-dependent mitochondrial calcium uptake but had no effect on the rate or extent of SV exocytosis. In contrast, the rate of SV endocytosis was increased in the absence of mitochondrial calcium uptake and slowed when MCU was overexpressed. MCU knockdown did not perturb activity-dependent increases in presynaptic free calcium, suggesting that SV endocytosis may be controlled by calcium accumulation and efflux from mitochondria in their immediate vicinity.

  2. Solar kinetics` photovoltaic concentrator module and tracker development

    Energy Technology Data Exchange (ETDEWEB)

    White, D.L.; Howell, B. [Solar Kinetics, Inc., Dallas, TX (United States)


    Solar Kinetics, Inc., has been developing a point-focus concentrating photovoltaic module and tracker system under contract to Sandia National Laboratories. The primary focus of the contract was to achieve a module design that was manufacturable and passed Sandia`s environmental testing. Nine modules of two variations were assembled, tested, and characterized in Phase 1, and results of these tests were promising, with module efficiency approaching the theoretical limit achievable with the components used. The module efficiency was 11.9% at a solar irradiance of 850 W/m{sup 2} and an extrapolated cell temperature of 25{degrees}C. Improvements in module performance are anticipated as cell efficiencies meet their expectations. A 2-kW tracker and controller accommodating 20 modules was designed, built, installed, and operated at Solar Kinetics` test site. The drive used many commercially available components in an innovative arrangement to reduce cost and increase reliability. Backlash and bearing play were controlled by use of preloaded, low slip-stick, synthetic slide bearings. The controller design used a standard industrial programmable logic controller to perform ephemeris calculations, operate the actuators, and monitor encoders.

  3. Rapid RNA-ligand interaction analysis through high-information content conformational and stability landscapes (United States)

    Baird, Nathan J.; Inglese, James; Ferré-D'Amaré, Adrian R.


    The structure and biological properties of RNAs are a function of changing cellular conditions, but comprehensive, simultaneous investigation of the effect of multiple interacting environmental variables is not easily achieved. We have developed an efficient, high-throughput method to characterize RNA structure and thermodynamic stability as a function of multiplexed solution conditions using Förster resonance energy transfer (FRET). In a single FRET experiment using conventional quantitative PCR instrumentation, 19,400 conditions of MgCl2, ligand and temperature are analysed to generate detailed empirical conformational and stability landscapes of the cyclic diguanylate (c-di-GMP) riboswitch. The method allows rapid comparison of RNA structure modulation by cognate and non-cognate ligands. Landscape analysis reveals that kanamycin B stabilizes a non-native, idiosyncratic conformation of the riboswitch that inhibits c-di-GMP binding. This demonstrates that allosteric control of folding, rather than direct competition with cognate effectors, is a viable approach for pharmacologically targeting riboswitches and other structured RNA molecules.

  4. Rapid RNA-ligand interaction analysis through high-information content conformational and stability landscapes

    Energy Technology Data Exchange (ETDEWEB)

    Baird, Nathan J. [National Inst. of Health (NIH), Bethesda, MD (United States); Inglese, James [National Inst. of Health (NIH), Bethesda, MD (United States); Ferré-D’Amaré, Adrian R. [National Inst. of Health (NIH), Bethesda, MD (United States)


    The structure and biological properties of RNAs are a function of changing cellular conditions, but comprehensive, simultaneous investigation of the effect of multiple interacting environmental variables is not easily achieved. We have developed an efficient, high-throughput method to characterize RNA structure and thermodynamic stability as a function of multiplexed solution conditions using Förster resonance energy transfer (FRET). In a single FRET experiment using conventional quantitative PCR instrumentation, 19,400 conditions of MgCl2, ligand and temperature are analysed to generate detailed empirical conformational and stability landscapes of the cyclic diguanylate (c-di-GMP) riboswitch. This method allows rapid comparison of RNA structure modulation by cognate and non-cognate ligands. Landscape analysis reveals that kanamycin B stabilizes a non-native, idiosyncratic conformation of the riboswitch that inhibits c-di-GMP binding. Our research demonstrates that allosteric control of folding, rather than direct competition with cognate effectors, is a viable approach for pharmacologically targeting riboswitches and other structured RNA molecules.

  5. Predicting Academic Achievement from Classroom Behaviors


    Flynt, Cynthia J.


    PREDICTING ACADEMIC ACHIEVEMENT FROM CLASSROOM BEHAVIORS by Cynthia J. Flynt Nancy Bodenhorn & Kusum Singh, Co-Chairs Counselor Education (ABSTRACT) This study examined the influence of behaviors exhibited in the classroom on reading and math achievement in the first, third and eighth grades; and the influence of teacher perceptions on reading and math achievement of African-Americans versus White students and male versus female students. Lastly, the study examined te...

  6. Cognitive abilities, sociocultural background and academic achievement


    Diniz, António; Pocinho, Margarida Maria Ferreira Diogo Dias; Almeida,Leandro Silva


    The infl uence of students’ sociocultural background on academic achievement is a well established fact. Research also points out that sociocultural background is related to students’ cognitive abilities and these have an effect on their academic achievement. However, the mediator role of cognitive abilities on the relationship between sociocultural background and academic achievement is less well known. A structural equation model that represents these relationships was tested in a sample...

  7. Spatial Terahertz Modulator (United States)

    Xie, Zhenwei; Wang, Xinke; Ye, Jiasheng; Feng, Shengfei; Sun, Wenfeng; Akalin, Tahsin; Zhang, Yan


    Terahertz (THz) technology is a developing and promising candidate for biological imaging, security inspection and communications, due to the low photon energy, the high transparency and the broad band properties of the THz radiation. However, a major encountered bottleneck is lack of efficient devices to manipulate the THz wave, especially to modulate the THz wave front. A wave front modulator should allow the optical or electrical control of the spatial transmission (or reflection) of an input THz wave and hence the ability to encode the information in a wave front. Here we propose a spatial THz modulator (STM) to dynamically control the THz wave front with photo-generated carriers. A computer generated THz hologram is projected onto a silicon wafer by a conventional spatial light modulator (SLM). The corresponding photo-generated carrier spatial distribution will be induced, which forms an amplitude hologram to modulate the wave front of the input THz beam. Some special intensity patterns and vortex beams are generated by using this method. This all-optical controllable STM is structure free, high resolution and broadband. It is expected to be widely used in future THz imaging and communication systems.

  8. Cost Modeling for SOC Modules Testing


    Balwinder Singh; Arun Khosla; Sukhleen B. Narang


    The complexity of the system design is increasing very rapidly as the number of transistors on Integrated Circuits (IC) doubles as per Moore’s law.There is big challenge of testing this complex VLSI circuit, in which whole system is integrated into a single chip called System on Chip (SOC). Cost of testing the SOC is also increasing with complexity. Cost modeling plays a vital role in reduction of test cost and time to market. This paper includes the cost modeling of the SOC Module testing...

  9. Dynamic behavior and complexity of modulated optical micro ring resonator

    Institute of Scientific and Technical Information of China (English)

    Lei Yang; Wei Pan; Bin Luo; ShuiYing Xiang; Ning Jiang


    @@ The dynamic behavior of an optical micro ring resonator (OMRR) with an amplitude modulator positioned in the micro ring is investigated quantitatively by adopting a recently introduced quantifier, the permutation entropy (PE).The effects of modulation depth are focused on, and the roles of input power are considered.The two-dimensional (2D) maps of PE showing dependence on both modulation depth and input power are presented as well.PE values nearly increase with modulation depth.On the other hand, the optimal value of input power is achieved when the PE reaches its maximum.Thus, PE can successfully quantify the dynamics of modulated OMRR.Selecting the parameters in the region with high PE values would contribute to the complexity-enhanced OMRR-based chaotic communication systems.%The dynamic behavior of an optical micro ring resonator (OMRR) with an amplitude modulator positioned in the micro ring is investigated quantitatively by adopting a recently introduced quantifier, the permutation entropy (PE). The effects of modulation depth are focused on, and the roles of input power are considered. The two-dimensional (2D) maps of PE showing dependence on both modulation depth and input power are presented as well. PE values nearly increase with modulation depth. On the other hand, the optimal value of input power is achieved when the PE reaches its maximum. Thus, PE can successfully quantify the dynamics of modulated OMRR. Selecting the parameters in the region with high PE values would contribute to the complexity-enhanced OMRR-based chaotic communication systems.

  10. Final Design of the SLAC P2 Marx Klystron Modulator

    Energy Technology Data Exchange (ETDEWEB)

    Kemp, M.A.; Benwell, A.; Burkhart, C.; Larsen, R.; MacNair, D.; Nguyen, M.; Olsen, J.; /SLAC


    The SLAC P2 Marx has been under development for two years, and follows on the P1 Marx as an alternative to the baseline klystron modulator for the International Linear Collider. The P2 Marx utilizes a redundant architecture, air-insulation, a control system with abundant diagnostic access, and a novel nested droop correction scheme. This paper is an overview of the design of this modulator. There are several points of emphasis for the P2 Marx design. First, the modulator must be compatible with the ILC two-tunnel design. In this scheme, the modulator and klystron are located within a service tunnel with limited access and available footprint for a modulator. Access to the modulator is only practical from one side. Second, the modulator must have high availability. Robust components are not sufficient alone to achieve availability much higher than 99%. Therefore, redundant architectures are necessary. Third, the modulator must be relatively low cost. Because of the large number of stations in the ILC, the investment needed for the modulator components is significant. High-volume construction techniques which take advantage of an economy of scale must be utilized. Fourth, the modulator must be simple and efficient to maintain. If a modulator does become inoperable, the MTTR must be small. Fifth, even though the present application for the modulator is for the ILC, future accelerators can also take advantage of this development effort. The hardware, software, and concepts developed in this project should be designed such that further development time necessary for other applications is minimal.

  11. Rapid thermal processing of semiconductors

    CERN Document Server

    Borisenko, Victor E


    Rapid thermal processing has contributed to the development of single wafer cluster processing tools and other innovations in integrated circuit manufacturing environments Borisenko and Hesketh review theoretical and experimental progress in the field, discussing a wide range of materials, processes, and conditions They thoroughly cover the work of international investigators in the field

  12. Rapid Prototyping Enters Mainstream Manufacturing. (United States)

    Winek, Gary


    Explains rapid prototyping, a process that uses computer-assisted design files to create a three-dimensional object automatically, speeding the industrial design process. Five commercially available systems and two emerging types--the 3-D printing process and repetitive masking and depositing--are described. (SK)

  13. China's Tire Industry Develops Rapidly

    Institute of Scientific and Technical Information of China (English)


    @@ With strenuous efforts over many years,the tire industry in China has developed rapidly. Both the output and the exported quantity of tires already hold the leading position in the world. China has quickly become a major player in the international tire industry and is making significant impacts.

  14. Rapid-Equilibrium Enzyme Kinetics (United States)

    Alberty, Robert A.


    Rapid-equilibrium rate equations for enzyme-catalyzed reactions are especially useful because if experimental data can be fit by these simpler rate equations, the Michaelis constants can be interpreted as equilibrium constants. However, for some reactions it is necessary to use the more complicated steady-state rate equations. Thermodynamics is…

  15. Rapid Energy Modeling Workflow Demonstration (United States)


    BIM Building Information Modeling BPA Building Performance Analysis BTU British Thermal Unit CBECS Commercial Building ...geometry, orientation, weather, and materials, generates 3D Building Information Models ( BIM ) guided by satellite views of building footprints and...Rapid Energy Modeling (REM) workflows that employed building information modeling ( BIM ) approaches and conceptual energy analysis.

  16. Portable Diagnostics and Rapid Germination

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, Zachary Spencer [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)


    In the Bioenergy and Defense Department of Sandia National Laboratories, characterization of the BaDx (Bacillus anthracis diagnostic cartridge) was performed and rapid germination chemistry was investigated. BaDx was tested with complex sample matrixes inoculated with Bacillus anthracis, and the trials proved that BaDx will detect Bacillus anthracis in a variety of the medium, such as dirt, serum, blood, milk, and horse fluids. The dimensions of the device were altered to accommodate an E. coli or Listeria lateral flow immunoassay, and using a laser printer, BaDx devices were manufactured to identify E. coli and Listeria. Initial testing with E. coli versions of BaDx indicate that the device will be viable as a portable diagnostic cartridge. The device would be more effective with faster bacteria germination; hence studies were performed the use of rapid germination chemistry. Trials with calcium dipicolinic acid displayed increased cell germination, as shown by control studies using a microplate reader. Upon lyophilization the rapid germination chemistry failed to change growth patterns, indicating that the calcium dipicolinic acid was not solubilized under the conditions tested. Although incompatible with the portable diagnostic device, the experiments proved that the rapid germination chemistry was effective in increasing cell germination.

  17. Knowledge Exchange Within the Rapid Climate Change Program (RAPID) (United States)

    Wallace, C.; Srokosz, M.


    The Rapid Climate Change Program (RAPID) is a major UK-led science program investigating the susceptibility to and risk of abrupt change in the climate system, with a particular focus on the role of the Atlantic Meridional Overturning Circulation (AMOC). RAPID commenced in 2001, with initial funding to 2008 and has just entered its second phase - RAPID-WATCH - extending some aspects of the program until 2014. Scientifically, a key focus of the program has concerned the development and deployment of a continuous AMOC observing system, although the program has also supported research into a number of other aspects of rapid climate change, including paleo studies of past rapid changes, modeling of the past and future climate, and the development of methods with which to aid the quantification of future risks. Given the societal implications that abrupt climate change associated with the AMOC may have for the North Atlantic region, a major focus within the program has been the implementation of a Knowledge Exchange strategy with which to engage key decision and policy makers within the UK political and industrial sectors. This interaction is especially pertinent for those decision makers involved in the development of adaptive capacities that must incorporate resilience to so-called high-impact, low-probability class threats. We will summarize here the main aspects of our approach, outlining activities/methods used both to satisfy the obvious need to transfer key scientific findings from the program to users, but also in facilitating a return flow of knowledge which can be used by scientists to refine the impact and utility of scientific output. We will draw on particular experience gained from the program's involvement in i: personnel exchanges with central government departments; ii: interaction and co-operation with third party stakeholder organizations (e.g. the UK Climate Impacts Program); and iii: provision of written and oral briefings. Throughout, techniques

  18. RRTM: A rapid radiative transfer model

    Energy Technology Data Exchange (ETDEWEB)

    Mlawer, E.J.; Taubman, S.J.; Clough, S.A. [Atmospheric and Environmental Research, Inc., Cambridge, MA (United States)


    A rapid radiative transfer model (RRTM) for the calculation of longwave clear-sky fluxes and cooling rates has been developed. The model, which uses the correlated-k method, is both accurate and computationally fast. The foundation for RRTM is the line-by-line radiative transfer model (LBLRTM) from which the relevant k-distributions are obtained. LBLRTM, which has been extensively validated against spectral observations e.g., the high-resolution sounder and the Atmospheric Emitted Radiance Interferometer, is used to validate the flux and cooling rate results from RRTM. Validations of RRTM`s results have been performed for the tropical, midlatitude summer, and midlatitude winter atmospheres, as well as for the four Intercomparison of Radiation Codes in Climate Models (ICRCCM) cases from the Spectral Radiance Experiment (SPECTRE). Details of some of these validations are presented below. RRTM has the identical atmospheric input module as LBLRTM, facilitating intercomparisons with LBLRTM and application of the model at the Atmospheric Radiation Measurement Cloud and Radiation Testbed sites.

  19. [Physiology of synapse: from molecular modules to retrograde modulation]. (United States)

    Brezhestovskiĭ, P D


    Synapses are highly organized, specific structures assuring rapid and highly selective interactions between cells. Synaptic transmission involves the release of neurotransmitter from presynaptic neurons and its detection by specific ligand-gated ion channels at the surface membrane of postsynaptic neurons. The protenomic analysis shows that for self-formation and functioning of synapses nearly 2000 proteins are involved in mammalian brain. The core complex in excitatory synapses includes glutamate receptors, potassium channels, CaMKII, scaffolding protein and actin. These proteins exist as part of a highly organized protein complex known as the postsynaptic density (PSD). The coordinated functioning of the different PSD components determines the strength of signalling between the pre- and postsynaptic neurons. Synaptic plasticity is regulated by changes in the amount of receptors on the postsynaptic membrane, changes in the shape and size of dendritic spines, posttranslational modification of PSD components, modulation kinetics of synthesis and degradation of proteins. Integration of these processes leads to long-lasting changes in synaptic function and neuronal networks underlying learning-related plasticity, memory and information treatment in nervous system of multicellular organisms.

  20. Well-being in Adolescents: the Impact of Family and Academic Achievement


    Xing, Rong


    Objective: Adolescence is a hallmark period filling with rapid changes and both positive and negative outcomes. Well-being is one of the most important outcomes should be pursued. The present study aimed to investigate the impact of family environment, academic achievement and parental expectations for educational attainment on emotional well-being among adolescents. Method: Well-being, family environment, academic achievement and parental expectations for educational attainment (PEEA) we...

  1. Achievement Goals and Discrete Achievement Emotions: A Theoretical Model and Prospective Test (United States)

    Pekrun, Reinhard; Elliot, Andrew J.; Maier, Markus A.


    A theoretical model linking achievement goals to discrete achievement emotions is proposed. The model posits relations between the goals of the trichotomous achievement goal framework and 8 commonly experienced achievement emotions organized in a 2 (activity/outcome focus) x 2 (positive/negative valence) taxonomy. Two prospective studies tested…

  2. Quantitative velocity modulation spectroscopy (United States)

    Hodges, James N.; McCall, Benjamin J.


    Velocity Modulation Spectroscopy (VMS) is arguably the most important development in the 20th century for spectroscopic study of molecular ions. For decades, interpretation of VMS lineshapes has presented challenges due to the intrinsic covariance of fit parameters including velocity modulation amplitude, linewidth, and intensity. This limitation has stifled the growth of this technique into the quantitative realm. In this work, we show that subtle changes in the lineshape can be used to help address this complexity. This allows for determination of the linewidth, intensity relative to other transitions, velocity modulation amplitude, and electric field strength in the positive column of a glow discharge. Additionally, we explain the large homogeneous component of the linewidth that has been previously described. Using this component, the ion mobility can be determined.

  3. Models for Modules

    CERN Document Server

    Troost, Jan


    We recall the structure of the indecomposable sl(2) modules in the Bernstein-Gelfand-Gelfand category O. We show that all these modules can arise as quantized phase spaces of physical models. In particular, we demonstrate in a path integral discretization how a redefined action of the sl(2) algebra over the complex numbers can glue finite dimensional and infinite dimensional highest weight representations into indecomposable wholes. Furthermore, we discuss how projective cover representations arise in the tensor product of finite dimensional and Verma modules and give explicit tensor product decomposition rules. The tensor product spaces can be realized in terms of product path integrals. Finally, we discuss relations of our results to brane quantization and cohomological calculations in string theory.

  4. Space Experiment Module (SEM) (United States)

    Brodell, Charles L.


    The Space Experiment Module (SEM) Program is an education initiative sponsored by the National Aeronautics and Space Administration (NASA) Shuttle Small Payloads Project. The program provides nationwide educational access to space for Kindergarten through University level students. The SEM program focuses on the science of zero-gravity and microgravity. Within the program, NASA provides small containers or "modules" for students to fly experiments on the Space Shuttle. The experiments are created, designed, built, and implemented by students with teacher and/or mentor guidance. Student experiment modules are flown in a "carrier" which resides in the cargo bay of the Space Shuttle. The carrier supplies power to, and the means to control and collect data from each experiment.

  5. GREET Pretreatment Module

    Energy Technology Data Exchange (ETDEWEB)

    Adom, Felix K. [Argonne National Lab. (ANL), Argonne, IL (United States). Energy Systems Division; Dunn, Jennifer B. [Argonne National Lab. (ANL), Argonne, IL (United States). Energy Systems Division; Han, Jeongwoo [Argonne National Lab. (ANL), Argonne, IL (United States). Energy Systems Division


    A wide range of biofuels and biochemicals can be produced from cellulosic biomass via different pretreatment technologies that yield sugars. Process simulations of dilute acid and ammonia fiber expansion pretreatment processes and subsequent hydrolysis were developed in Aspen Plus for four lignocellulosic feedstocks (corn stover, miscanthus, switchgrass, and poplar). This processing yields sugars that can be subsequently converted to biofuels or biochemical. Material and energy consumption data from Aspen Plus were then compiled in a new Greenhouses Gases, Regulated Emissions, and Energy Use in Transportation (GREETTM) pretreatment module. The module estimates the cradle-to-gate fossil energy consumption (FEC) and greenhouse gas (GHG) emissions associated with producing fermentable sugars. This report documents the data and methodology used to develop this module and the cradle-to-gate FEC and GHG emissions that result from producing fermentable sugars.

  6. Hollow dimension of modules

    Institute of Scientific and Technical Information of China (English)


    In this paper, we are interested in the following general question: Given a module Mwhich has finite hollow dimension and which has a finite collection of submodules Ki (1≤i≤n) such that M=K1+... +Kn, can we find an expression for the hollow dimension of Min terms of hollow dimensions of modules built up in some way from K1 Kn? We prove the following theorem:Let Mbe an amply supplemented module having finite hollow dimension and let Ki (1≤i≤n) be a finite collection of submodules of Msuch that M=K1+...+Kn. Then the hollow dimension h(M) of Mis the sum of the hollow dimensions of Ki (1≤i≤n) ifand only if Ki is a supplement of K1+...+Ki-1+Ki+1+...+Kn in Mfor each 1≤i≤n.

  7. Power module assembly (United States)

    Campbell, Jeremy B [Torrance, CA; Newson, Steve [Redondo Beach, CA


    A power module assembly of the type suitable for deployment in a vehicular power inverter, wherein the power inverter has a grounded chassis, is provided. The power module assembly comprises a conductive base layer electrically coupled to the chassis, an insulating layer disposed on the conductive base layer, a first conductive node disposed on the insulating layer, a second conductive node disposed on the insulating layer, wherein the first and second conductive nodes are electrically isolated from each other. The power module assembly also comprises a first capacitor having a first electrode electrically connected to the conductive base layer, and a second electrode electrically connected to the first conductive node, and further comprises a second capacitor having a first electrode electrically connected to the conductive base layer, and a second electrode electrically connected to the second conductive node.

  8. Rapid cavity prototyping using mode matching and globalised scattering matrix

    CERN Document Server

    Shinton, I


    Cavity design using traditional mesh based numerical means (such as the finite element or finite difference methods) require large mesh calculations in order to obtain accurate values and cavity optimisation is often not achieved. Here we present a mode matching scheme which utilises a globalised scattering matrix approach that allows cavities with curved surfaces (i.e. cavities with elliptical irises and or equators) to be accurately simulated allowing rapid cavity prototyping and optimisation to be achieved. Results on structures in the CLIC main

  9. Achieving High Resolution Ion Mobility Separations Using Traveling Waves in Compact Multiturn Structures for Lossless Ion Manipulations

    Energy Technology Data Exchange (ETDEWEB)

    Hamid, Ahmed M.; Garimella, Sandilya V. B.; Ibrahim, Yehia M.; Deng, Liulin; Zheng, Xueyun; Webb, Ian K.; Anderson, Gordon A.; Prost, Spencer A.; Norheim, Randolph V.; Tolmachev, Aleksey V.; Baker, Erin S.; Smith, Richard D.


    We report on ion mobility separations (IMS) achievable using traveling waves in a Structures for Lossless Ion Manipulations (TW-SLIM) module having a 44-cm path length and sixteen 90º turns. The performance of the TW-SLIM module was evaluated for ion transmission, and ion mobility separations with different RF, TW parameters and SLIM surface gaps in conjunction with mass spectrometry. In this work TWs were created by the transient and dynamic application of DC potentials. The TW-SLIM module demonstrated highly robust performance and the ion mobility resolution achieved even with sixteen close spaced turns was comparable to a similar straight path TW-SLIM module. We found an ion mobility peak capacity of ~ 31 and peak generation rate of 780 s-1 for TW speeds of <210 m/s using the current multi-turn TW-SLIM module. The separations achieved for isomers of peptides and tetrasaccharides were found to be comparable to those from a ~ 0.9-m drift tube-based IMS-MS platform operated at the same pressure (4 torr). The combined attributes of flexible design, low voltage requirements and lossless ion transmission through multiple turns for the present TW-SLIM module provides a basis for SLIM devices capable of achieving much greater ion mobility resolutions via greatly extended ion path lengths and compact serpentine designs that do not significantly impact the instrumentation profile, a direction described in a companion manuscript.

  10. Motor modules in robot-aided walking

    Directory of Open Access Journals (Sweden)

    Gizzi Leonardo


    Full Text Available Abstract Background It is hypothesized that locomotion is achieved by means of rhythm generating networks (central pattern generators and muscle activation generating networks. This modular organization can be partly identified from the analysis of the muscular activity by means of factorization algorithms. The activity of rhythm generating networks is described by activation signals whilst the muscle intervention generating network is represented by motor modules (muscle synergies. In this study, we extend the analysis of modular organization of walking to the case of robot-aided locomotion, at varying speed and body weight support level. Methods Non Negative Matrix Factorization was applied on surface electromyographic signals of 8 lower limb muscles of healthy subjects walking in gait robotic trainer at different walking velocities (1 to 3km/h and levels of body weight support (0 to 30%. Results The muscular activity of volunteers could be described by low dimensionality (4 modules, as for overground walking. Moreover, the activation signals during robot-aided walking were bursts of activation timed at specific phases of the gait cycle, underlying an impulsive controller, as also observed in overground walking. This modular organization was consistent across the investigated speeds, body weight support level, and subjects. Conclusions These results indicate that walking in a Lokomat robotic trainer is achieved by similar motor modules and activation signals as overground walking and thus supports the use of robotic training for re-establishing natural walking patterns.

  11. Broadband microwave phase shifter based on high speed cross gain modulation in quantum dot semiconductor optical amplifiers

    DEFF Research Database (Denmark)

    Chen, Yaohui; Mørk, Jesper


    We present a scheme to achieve tunable ~180 degrees microwave phase shifts at frequencies exceeding 100 GHz based on high speed cross gain modulation in quantum dot semiconductor optical amplifiers.......We present a scheme to achieve tunable ~180 degrees microwave phase shifts at frequencies exceeding 100 GHz based on high speed cross gain modulation in quantum dot semiconductor optical amplifiers....

  12. Stirling Module Development Overview (United States)

    Livingston, F. R.


    The solar parabolic dish Stirling engine electrically generating module consists of a solar collector coupled to a Stirling engine powered electrical generator. The module is designed to convert solar power to electrical power in parallel with numerous identical units coupled to an electrical utility power grid. The power conversion assembly generates up to 25 kilowatts at 480 volts potential/3 phase/alternating current. Piston rings and seals with gas leakage have not occurred, however, operator failures resulted in two burnt out receivers, while material fatigue resulted in a broken piston rod between the piston rod seal and cap seal.

  13. Lunar Module Illustration (United States)


    This concept is a cutaway illustration of the Lunar Module (LM) with detailed callouts. The LM was a two part spacecraft. Its lower or descent stage had the landing gear, engines, and fuel needed for the landing. When the LM blasted off the Moon, the descent stage served as the launching pad for its companion ascent stage, which was also home for the two astronauts on the surface of the Moon. The LM was full of gear with which to communicate, navigate, and rendezvous. It also had its own propulsion system, and an engine to lift it off the Moon and send it on a course toward the orbiting Command Module.

  14. Modulating aging and longevity

    DEFF Research Database (Denmark)

    Rattan, Suresh

    Provides information and an evaluation of a variety of approaches tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. After decades of systematic....... This book provides the most up-to-date information and a critical evaluation of a variety of approaches being tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress...

  15. Instant node package module

    CERN Document Server

    Ali, Juzer


    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. A practical exploration of the lifecycle of creating node modules as well as learning all of the top features that npm has to offer.Intended for readers who want to create their first node.js modules. The programming paradigm of JavaScript is not covered so a foundation in these concepts would be beneficial.

  16. Pain and modulation processes

    Directory of Open Access Journals (Sweden)

    Ghaffarpoor M


    Full Text Available Pain is one of the most important and sometimes difficult problems, that patients and physicians are encountered. It may be clinically acute or chronic, acute pain has usually definite cause and favourable response to treatment. On the other hand there are difficulties in diagnosis and management of chronic pain. Peripheral and cranial nerves convey pain impulses toward central nervous system, and modulations take place at several levels. Diagnosis of different pains, including nociceptive, nerve trunk pain and deafferentation types is essential to acceptable management. In this article we review pain pathway, neurotransmitters and modulation.

  17. Flexible programmable logic module

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, Perry J. (Albuquerque, NM); Hutchinson, Robert L. (Albuquerque, NM); Pierson, Lyndon G. (Albuquerque, NM)


    The circuit module of this invention is a VME board containing a plurality of programmable logic devices (PLDs), a controlled impedance clock tree, and interconnecting buses. The PLDs are arranged to permit systolic processing of a problem by offering wide data buses and a plurality of processing nodes. The board contains a clock reference and clock distribution tree that can drive each of the PLDs with two critically timed clock references. External clock references can be used to drive additional circuit modules all operating from the same synchronous clock reference.

  18. Multimedia Technology and Students' Achievement in Geography (United States)

    DaSilva, Edmar Bernardes; Kvasnak, Robb Neil


    In this study done at a community college in South Florida, the achievements of students who spoke English as their second language who had attended their K-12 education outside the United States in their home countries, in a U.S. college course on world geography are compared with the achievements of students in the same classes who spoke English…

  19. Achievement and Its Correlates: Symposium III A. (United States)

    Ismail, Maznah; And Others

    This symposium contains a report of a study which (1) examined the relationship between Malaysian children's perception of control and their academic achievement, by Maznah Ismail and Choo Piang Foong, and two abstracts of studies which (2) investigated achievement motivation and attribution of success in rural and urban Malaysian ethnic groups,…

  20. Professional Learning Communities Impact on Student Achievement (United States)

    Hamilton, Jan L.


    This study examined the impact of the Professional Learning Community model on student achievement in the state of California. Specifically, the study compared student achievement between two school types: Professional Learning Community schools and Non Professional Learning schools. The research utilized existing API scores for California schools…

  1. Physical Environment and Middle Grade Achievement. (United States)

    Chan, Tak Cheung

    This study measured the influence of air conditioning, carpeting, fluorescent lighting, and interior pastel coloring on the academic achievement of eighth grade Georgia pupils in 1975-76 when the variance due to socioeconomic status was statistically controlled. Analysis of covariance was used to compare the achievement scores of students on the…

  2. Health and Nutrition: Preconditions for Educational Achievement. (United States)

    Negussie, Birgit

    This paper discusses the importance of maternal and infant health for children's educational achievement. Education, health, and nutrition are so closely related that changes in one causes changes in the others. Improvement of maternal and preschooler health and nutrition is a precondition for improved educational achievement. Although parental…

  3. Achieving scale strategies for sustained competitive performance. (United States)

    Grube, Mark E; Gish, Ryan S; Tkach, Sasha N


    Growth to achieve scale requires the following strategic initiatives: Having a clear understanding of what the organization is and what it wants to become. Ensuring a structured and rigorous growth process. Leveraging size to achieve benefits of scale. Recognizing the importance of physicians, ambulatory care, and primary care. Establishing and maintaining accountability as growth occurs.

  4. Psychological Adjustment and Academic Achievement among Adolescents (United States)

    Mahmood, Khalid; Iqbal, Muhammad Maqsood


    This study was studied that emotional and behavioural problems of young students who are directly related to their academic achievement and thus play a vital role in the development of young learners carrier. This study helped to fill a gap by conducting an exploration of psychological adjustment and academic achievement among adolescents. It also…

  5. Achieve inventory reduction and improve customer service? (United States)

    Moody, M C


    Is it really possible to achieve significant reductions in your manufacturing inventories while improving customer service? If you really want to achieve significant inventory reductions, focus on the root causes, and develop countermeasures and a work plan, to execute your countermeasures. Include measurements for recording your progress, and deploy your countermeasures until they are no longer required, or until new ones are needed.

  6. A Multivariate Model of Achievement in Geometry (United States)

    Bailey, MarLynn; Taasoobshirazi, Gita; Carr, Martha


    Previous studies have shown that several key variables influence student achievement in geometry, but no research has been conducted to determine how these variables interact. A model of achievement in geometry was tested on a sample of 102 high school students. Structural equation modeling was used to test hypothesized relationships among…

  7. Photovoltaic module and interlocked stack of photovoltaic modules (United States)

    Wares, Brian S.


    One embodiment relates to an arrangement of photovoltaic modules configured for transportation. The arrangement includes a plurality of photovoltaic modules, each photovoltaic module including a frame having at least a top member and a bottom member. A plurality of alignment features are included on the top member of each frame, and a plurality of alignment features are included on the bottom member of each frame. Adjacent photovoltaic modules are interlocked by the alignment features on the top member of a lower module fitting together with the alignment features on the bottom member of an upper module. Other embodiments, features and aspects are also disclosed.

  8. Design considerations and performance characteristics of high concentration point-focussing photovoltaic modules

    Energy Technology Data Exchange (ETDEWEB)

    Sanders, J.A.; Broadbent, S.


    Through the auspices of the Department of Energy, the Fresnel lens point-focussing photovoltaic module has evolved into a commercially available, high efficiency low cost option for converting solar energy into electricity. The 15.4% efficient baseline module is undergoing several design improvements to achieve higher efficiencies at high concentrations and lower cost. A 16.5% module will be available in 1984 and 18% Gallium Arsenide modules in 1985. This paper describes the design details and performance characteristics of the baseline module and the design improvements.

  9. Novel Electro-Optical Modulator Utilizing GeO2-Doped Silica Waveguide

    Institute of Scientific and Technical Information of China (English)

    LI Jiusheng; JIA Dagong


    In order to achieve a modulator with broad bandwidth and perfect impedance match,a novel electro-optical modulator based on GeO2-doped silica waveguides on silicon substrate is designed.The finite element model of the whole electro-optical modulator is established by means of ANSYS.With the finite element method analysis,the performance of the novel modulator is predicted.The simulation reveals that the designed modulator operates with a product of 3 dB optical bandwidth and modulating length of 226.59 GHz-cm,and a characteristic impedance of 51.6 Ω at 1 550 nm wavelength.Moreover,the calculated electrical reflected power of coplanar waveguide electrode is below -20 dB in the frequency ranging from 45 MHz to 65 GHz.Therefore,the designed modulator has wide modulation bandwidth and perfect impedance match.

  10. Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes.

    Directory of Open Access Journals (Sweden)

    Andrew B Goryachev


    Full Text Available Formation of multiprotein complexes on cellular membranes is critically dependent on the cyclic activation of small GTPases. FRAP-based analyses demonstrate that within protein complexes, some small GTPases cycle nearly three orders of magnitude faster than they would spontaneously cycle in vitro. At the same time, experiments report concomitant excess of the activated, GTP-bound form of GTPases over their inactive form. Intuitively, high activity and rapid turnover are contradictory requirements. How the cells manage to maximize both remains poorly understood. Here, using GTPases of the Rab and Rho families as a prototype, we introduce a computational model of the GTPase cycle. We quantitatively investigate several plausible layouts of the cycling control module that consist of GEFs, GAPs, and GTPase effectors. We explain the existing experimental data and predict how the cycling of GTPases is controlled by the regulatory proteins in vivo. Our model explains distinct and separable roles that the activating GEFs and deactivating GAPs play in the GTPase cycling control. While the activity of GTPase is mainly defined by GEF, the turnover rate is a sole function of GAP. Maximization of the GTPase activity and turnover rate places conflicting requirements on the concentration of GAP. Therefore, to achieve a high activity and turnover rate at once, cells must carefully maintain concentrations of GEFs and GAPs within the optimal range. The values of these optimal concentrations indicate that efficient cycling can be achieved only within dense protein complexes typically assembled on the membrane surfaces. We show that the concentration requirement for GEF can be dramatically reduced by a GEF-activating GTPase effector that can also significantly boost the cycling efficiency. Interestingly, we find that the cycling regimes are only weakly dependent on the concentration of GTPase itself.

  11. Use of electrochemical DNA biosensors for rapid molecular identification of uropathogens in clinical urine specimens. (United States)

    Liao, Joseph C; Mastali, Mitra; Gau, Vincent; Suchard, Marc A; Møller, Annette K; Bruckner, David A; Babbitt, Jane T; Li, Yang; Gornbein, Jeffrey; Landaw, Elliot M; McCabe, Edward R B; Churchill, Bernard M; Haake, David A


    We describe the first species-specific detection of bacterial pathogens in human clinical fluid samples using a microfabricated electrochemical sensor array. Each of the 16 sensors in the array consisted of three single-layer gold electrodes-working, reference, and auxiliary. Each of the working electrodes contained one representative from a library of capture probes, each specific for a clinically relevant bacterial urinary pathogen. The library included probes for Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Enterocococcus spp., and the Klebsiella-Enterobacter group. A bacterial 16S rRNA target derived from single-step bacterial lysis was hybridized both to the biotin-modified capture probe on the sensor surface and to a second, fluorescein-modified detector probe. Detection of the target-probe hybrids was achieved through binding of a horseradish peroxidase (HRP)-conjugated anti-fluorescein antibody to the detector probe. Amperometric measurement of the catalyzed HRP reaction was obtained at a fixed potential of -200 mV between the working and reference electrodes. Species-specific detection of as few as 2,600 uropathogenic bacteria in culture, inoculated urine, and clinical urine samples was achieved within 45 min from the beginning of sample processing. In a feasibility study of this amperometric detection system using blinded clinical urine specimens, the sensor array had 100% sensitivity for direct detection of gram-negative bacteria without nucleic acid purification or amplification. Identification was demonstrated for 98% of gram-negative bacteria for which species-specific probes were available. When combined with a microfluidics-based sample preparation module, the integrated system could serve as a point-of-care device for rapid diagnosis of urinary tract infections.

  12. Photosensitizers for photodynamic immune modulation (United States)

    North, John R.; Boch, Ronald; Hunt, David W. C.; Ratkay, Leslie G.; Simkin, Guillermo O.; Tao, Jing-Song; Richter, Anna M.; Levy, Julia G.


    PDT may be an effective treatment for certain immune-mediated disorders. The immunomodulatory action of PDT is likely a consequence of effects exerted at a number of levels including stimulation of specific cell signaling pathways, selective depletion of activated immune cells, alteration of receptor expression by immune and non-immune cells, and the modulation of cytokine availability. QLT0074, a potent photosensitizer that exhibits rapid clearance kinetics in vivo, is in development for the treatment of immune disorders. In comparison to the well-characterized and structurally related photosensitizer verteporfin, lower concentrations of QLT0074 were required to induce apoptosis in human blood T cells and keratinocytes using blue light for photoactivation. Both photosensitizers triggered the stress activated protein kinase (SAPK) and p38 (HOG1) pathways but not extracellularly regulated kinase (ERK) activity in mouse Pam212 keratinocytes. In cell signaling responses, QLT0074 was active at lower concentrations than verteporfin. For all in vitro test systems, the stronger photodynamic activity of QLT0074 was associated with a greater cell uptake of this photosensitize than verteporfin. In mouse immune models, sub-erythemogenic doses of QLT0074 in combination with whole body blue light irradiation inhibited the contact hypersensitivity response and limited the development of adjuvant-induced arthritis. QLT0074 exhibits activities that indicate it may be a favorable agent for the photodynamic treatment of human immune disease.

  13. Circadian modulation of sleep in rodents. (United States)

    Yasenkov, Roman; Deboer, Tom


    Sleep is regulated by circadian and homeostatic processes. The sleep homeostat keeps track of the duration of prior sleep and waking and determines the intensity of sleep. In mammals, the homeostatic process is reflected by the slow waves in the non-rapid eye movement (NREM) sleep electroencephalogram (EEG). The circadian process is controlled by a pacemaker located in the suprachiasmatic nucleus of the hypothalamus and provides the sleep homeostat with a circadian framework. This review summarizes the changes in sleep obtained after different chronobiological interventions (changes in photoperiod, light availability, and running wheel availability), the influence of mutations or lesions in clock genes on sleep, and research on the interaction between sleep homeostasis and the circadian clock. Research in humans shows that the period of consolidated waking during the day is a consequence of the interaction between an increasing homeostatic sleep drive and a circadian signal, which promotes waking during the day and sleep during the night. In the rat, it was shown that, under constant homeostatic sleep pressure, with similar levels of slow waves in the NREM sleep EEG at all time points of the circadian cycle, still a small circadian modulation of the duration of waking and NREM sleep episodes was observed. Under similar conditions, humans show a clear circadian modulation in REM sleep, whereas in the rat, a circadian modulation in REM sleep was not present. Therefore, in the rat, the sleep homeostatic modulation in phase with the circadian clock seems to amplify the relatively weak circadian changes in sleep induced by the circadian clock. Knowledge about the interaction between sleep and the circadian clock and the circadian modulation of sleep in other species than humans is important to better understand the underlying regulatory mechanisms.

  14. Rapid variability of OB-stars: nature and diagnostic value. (United States)

    Baade, D.

    In the past decade, rapid photospheric variability has been recognized as the non-standard property that perhaps is the most common one among early-type stars. These proceedings offer an unusually complete overview of the existing observations. They are equally complete in their reflectance of the presently considered models. Because the simple definition 'on a rotational time scale' of the qualifier 'rapid' used in the title is very adequate for many stars, modulation is a strong contender also as a general model. The model that can be made to formally reproduce the widest range of observations is nonradial pulsation which, therefore, has earned itself the somewhat ambiguous reputation as a model for everything. An attraction of this model is that it would give the possibility to infer also structural and evolutionary quantities. It was the second purpose of the workshop to offer at least a glimpse of this potential.

  15. Equatorially trapped convection in a rapidly rotating spherical shell (United States)

    Miquel, Benjamin; Julien, Keith; Knobloch, Edgar


    Convection plays a preponderant role in driving geophysical flows. Unfortunately, these flows are often characterized by rapid rotation (i.e. small Ekman number E) which renders the equations stiff and introduces a scale separation in the system: for example the wavelength of the marginal mode at the onset of convection in a rapidly rotating sphere scales like E 1 / 3 and is modulated by a E 1 / 6 envelope. These scalings keep the fully nonlinear dynamics of the internal convection in Earth's core (E 1015) out of reach from direct numerical simulations, analytical work and experiments on one hand, but advocate for the development of reduced models on the other hand. We present a reduced model derived in a shallow gap spherical shell geometry. As the Rayleigh number is increased, the flow is first destabilized in the equatorial region where the dynamics remains trapped. The linear stability is analyzed and the fully nonlinear dynamics is presented.

  16. LS1 Report: achieving the unachievable

    CERN Multimedia

    Anaïs Schaeffer


    The dismantling and extraction of a defective DFBA module from LHC Point 6, announced a few weeks ago, has been completed without a hitch. The DFBAs in the LHC are unique and irreplaceable components that must be handled with care.   The Transport team extract the defective module in one of the two DFBAs at Point 6. This module was brought to the surface, where it is currently being repared. Dismantling and extracting part of an electrical feed box (DFBA) had not been planned and could not have been foreseen. Nonetheless, that is what had to be done. When the LS1 teams discovered that the bellows of one of the DFBAs in Sector 5-6 were damaged - and completely inaccessible - they were not exactly overwhelmed with solutions. In fact, they had only one option: to dismantle them and take them up to the surface. Step 1: measure the alignment of the module to be taken out in relation to the beam lines to ensure that when the DFBA is put back in, it is in the right position for the beam to pass thr...

  17. Design Elements and Electrical Performance of a Bifacial BIPV Module

    Directory of Open Access Journals (Sweden)

    Jun-Gu Kang


    Full Text Available Bifacial BIPV systems have great potential when applied to buildings given their use of a glass-to-glass structure. However, the performance of bifacial solar cells depends on a variety of design factors. Therefore, in order to apply bifacial solar cells to buildings, a bifacial PV module performance analysis should be carried out, including consideration of the various design elements and reflecting a wide range of installation conditions. This study focuses on the performance of a bifacial BIPV module applied to a building envelope. The results here show that the design elements of reflectivity and the transparent space ratio have the greatest impact on performance levels. The distance between the module and the wall had less of an impact on performance. The bifacial BIPV module produced output up to 30% greater than the output of monofacial PV modules, depending on the design elements. Bifacial BIPV modules themselves should have transparent space ratios of at least 30%. When a dark color is used on the external wall with reflectivity of 50% or less, bifacial BIPV modules with transparent space ratios of 40% and above should be used. In order to achieve higher performance through the installation of bifacial BIPV modules, design conditions which facilitate reflectivity exceeding 50% and a transparent space ratio which exceeds 30% must be met.

  18. Scaling: An Items Module (United States)

    Tong, Ye; Kolen, Michael J.


    "Scaling" is the process of constructing a score scale that associates numbers or other ordered indicators with the performance of examinees. Scaling typically is conducted to aid users in interpreting test results. This module describes different types of raw scores and scale scores, illustrates how to incorporate various sources of…

  19. Coplanar interconnection module (United States)

    Steward, R. D.; Windsor, H. F.


    Module for interconnecting a semiconductor array to external leads or components incorporates a metal external heat sink for cooling the array. Heat sink, extending down from the molded block that supports the array, is immersed in a liquid nitrogen bath which is designed to maintain the desired array temperature.

  20. An Integrated Teaching Module. (United States)

    Samuel, Marie R.; Seiferth, Berniece B.

    This integrated teaching module provides elementary and junior high school teachers with a "hands-on" approach to studying the Anasazi Indian. Emphasis is on creative exploration that focuses on integrating art, music, poetry, writing, geography, dance, history, anthropology, sociology, and archaeology. Replicas of artifacts,…

  1. Modelling the Photovoltaic Module

    DEFF Research Database (Denmark)

    Katsanevakis, Markos


    This paper refers into various ways in simulation the Photovoltaic (PV) module behaviour under any combination of solar irradiation and ambient temperature. There are three different approaches presented here briefly and one of them is chosen because of its good accuracy and relatively low...

  2. Multicultural Education Module. (United States)

    Campbell-Whatley, Gloria D.

    The purpose of this multicultural education module is to provide faculty, teachers, and administrators with a resource that will aid them in creating an environment that is amenable to diverse social and cultural groups within U.S. school systems. The guide identifies current resources for addressing issues with respect to cultural diversity and…

  3. Paratransit: An Instructional Module. (United States)

    Scalici, Anthony

    A concept-based introduction to paratransit is provided in this instructional module for undergraduate and graduate transportation-related courses for disciplines such as engineering, business, marketing, and technology. The concept of paratransit generally refers to modes of transportation other than mass transit and solo-driven automobiles. The…

  4. A rapidly growing lid lump (United States)

    Koay, Su-Yin; Lee, Richard M H; Hugkulstone, Charles; Rodrigues, Ian Aureliano Stephen


    A 97-year-old woman presented with a 5-month history of a rapidly growing, painless, left upper eyelid lesion. Examination revealed a large vascularised, ulcerated nodule on the left upper lid, causing significant ptosis. Wide local excision of the lesion was performed and the wound was left to heal by secondary intention. Histology and immunohistochemistry of the lesion confirmed a diagnosis of Merkel cell carcinoma, a rare primary malignancy of the eyelid which has significant morbidity and mortality. Although uncommon, this diagnosis should always be considered in any patient with a rapidly growing lid lump. In view of the patient's age, known dementia and family wishes, the patient was managed conservatively, with no further investigations performed. She was due to be followed up in clinic on a regular basis, but has since died from other causes. PMID:25123568

  5. Rapid synthesis of beta zeolites (United States)

    Fan, Wei; Chang, Chun -Chih; Dornath, Paul; Wang, Zhuopeng


    The invention provides methods for rapidly synthesizing heteroatom containing zeolites including Sn-Beta, Si-Beta, Ti-Beta, Zr-Beta and Fe-Beta. The methods for synthesizing heteroatom zeolites include using well-crystalline zeolite crystals as seeds and using a fluoride-free, caustic medium in a seeded dry-gel conversion method. The Beta zeolite catalysts made by the methods of the invention catalyze both isomerization and dehydration reactions.

  6. Dispassionate Thinking amid Rapid Urbanization

    Institute of Scientific and Technical Information of China (English)


    <正> By the end of 2003, the GDP per capita of China was over US$1,000, which means that China has reached the climax of industrialization. As industrialization is a driving force for the rapid development of cities, it should be brought to the agenda to accelerate the urbanization process and expand the city scale so as to meet the requirements of economic development.

  7. Fundamentals of spread spectrum modulation

    CERN Document Server

    Ziemer, Rodger E


    This lecture covers the fundamentals of spread spectrum modulation, which can be defined as any modulation technique that requires a transmission bandwidth much greater than the modulating signal bandwidth, independently of the bandwidth of the modulating signal. After reviewing basic digital modulation techniques, the principal forms of spread spectrum modulation are described. One of the most important components of a spread spectrum system is the spreading code, and several types and their characteristics are described. The most essential operation required at the receiver in a spread spect

  8. Student academic achievement in college chemistry (United States)

    Tabibzadeh, Kiana S.

    General Chemistry is required for variety of baccalaureate degrees, including all medical related fields, engineering, and science majors. Depending on the institution, the prerequisite requirement for college level General Chemistry varies. The success rate for this course is low. The purpose of this study is to examine the factors influencing student academic achievement and retention in General Chemistry at the college level. In this study student achievement is defined by those students who earned grades of "C" or better. The dissertation contains in-depth studies on influence of Intermediate Algebra as a prerequisite compared to Fundamental Chemistry for student academic achievement and student retention in college General Chemistry. In addition the study examined the extent and manner in which student self-efficacy influences student academic achievement in college level General Chemistry. The sample for this part of the study is 144 students enrolled in first semester college level General Chemistry. Student surveys determined student self-efficacy level. The statistical analyses of study demonstrated that Fundamental Chemistry is a better prerequisite for student academic achievement and student retention. The study also found that student self-efficacy has no influence on student academic achievement. The significance of this study will be to provide data for the purpose of establishing a uniform and most suitable prerequisite for college level General Chemistry. Finally the variables identified to influence student academic achievement and enhance student retention will support educators' mission to maximize the students' ability to complete their educational goal at institutions of higher education.

  9. Ultra-compact plasmonic waveguide modulators

    DEFF Research Database (Denmark)

    Babicheva, Viktoriia

    -compatible materials, both passive and active plasmonic waveguide components are important. Among other proposed plasmonic waveguides and modulators, the structures where the dielectric core is sandwiched between metal plates have been shown as one of the most compact and efficient layout. Because of the tight mode...... confinement that can be achieved in metal-insulator-metal structures, they provide a base for extremely fast and efficient ultracompact plasmonic devices, including modulators, photodetectors, lasers and amplifiers. The main result of this thesis is a systematic study of various designs of plasmonic......Metal-dielectric interfaces can support the waves known as surface plasmon polaritons, which are tightly coupled to the interface and allow manipulation of light at the nanoscale. Plasmonics as a subject which studies such waves enables the merge between two major technologies: nanometer...

  10. Modulation transfer functions at Ka band (United States)

    Hesany, Vahid; Sistani, Bita; Salam, Asif; Haimov, Samuel; Gogineni, Prasad; Moore, Richard K.

    The modulation transfer function (MTF) is often used to describe the modulation of the radar signal by the long waves. MTFs were measured at 35 GHz (Ka band) with a switched-beam vector slope gauge/scatterometer on the research platform NORDSEE as part of the SAXON-FPN experiment. Three independent measurements of the scattering were available for each height measurement. This provided the opportunity to average the time series to reduce the effects of fading noise and sea spikes, or, alternatively, to append the time series to achieve more degrees of freedom in the spectral estimates. For upwind measurements, the phase of the VV-polarized Ka-band MTF was always positive, which implies that the maximum of the radar return originates from the forward face of the long-scale waves. This phase increases with increasing wind speed. The magnitude of the MTF decreases with increasing wind speed.

  11. A product module mining method for PLM database

    Institute of Scientific and Technical Information of China (English)

    雷佻钰; 彭卫平; 雷金; 钟院华; 张秋华; 窦俊豪


    Modular technology can effectively support the rapid design of products, and it is one of the key technologies to realize mass customization design. With the application of product lifecycle management (PLM) system in enterprises, the product lifecycle data have been effectively managed. However, these data have not been fully utilized in module division, especially for complex machinery products. To solve this problem, a product module mining method for the PLM database is proposed to improve the effect of module division. Firstly, product data are extracted from the PLM database by data extraction algorithm. Then, data normalization and structure logical inspection are used to preprocess the extracted defective data. The preprocessed product data are analyzed and expressed in a matrix for module mining. Finally, the fuzzy c-means clustering (FCM) algorithm is used to generate product modules, which are stored in product module library after module marking and post-processing. The feasibility and effectiveness of the proposed method are verified by a case study of high pressure valve.

  12. Personality and academic achievement in nniversity students

    Directory of Open Access Journals (Sweden)

    Isabel Niño de Guzmán


    Full Text Available The correlations among personality, academic performance and other variables in 170 university students were studied, using two instruments validated into the population: the NEOPJ-R, and the EPPS. Other variables as age, study level, self perception of academic achievement and self perception of motivation, and sources of support were included. Jt was confirmed the reliability and validity of both tests and the correlations between them. The results showed associations among academic performance and conscientiousness, endurance,change, and aggression. The academic performance was better explained by achievements triving, deliberation, change, self perception of academic achievement and age.

  13. Limited feedback achieves the empirical capacity

    CERN Document Server

    Eswaran, Krishnan; Sahai, Anant; Gastpar, Michael


    The utility of limited feedback for coding over an individual sequence of DMCs is investigated. This study complements recent results showing how limited or noisy feedback can boost the reliability of communication. A strategy with fixed input distribution $P$ is given that asymptotically achieves rates arbitrarily close to the mutual information induced by $P$ and the state-averaged channel. When the capacity achieving input distribution is the same over all channel states, this achieves rates at least as large as the capacity of the state averaged channel, sometimes called the empirical capacity.

  14. Scalable Light Module for Low-Cost, High-Efficiency Light- Emitting Diode Luminaires

    Energy Technology Data Exchange (ETDEWEB)

    Tarsa, Eric [Cree, Inc., Goleta, CA (United States)


    During this two-year program Cree developed a scalable, modular optical architecture for low-cost, high-efficacy light emitting diode (LED) luminaires. Stated simply, the goal of this architecture was to efficiently and cost-effectively convey light from LEDs (point sources) to broad luminaire surfaces (area sources). By simultaneously developing warm-white LED components and low-cost, scalable optical elements, a high system optical efficiency resulted. To meet program goals, Cree evaluated novel approaches to improve LED component efficacy at high color quality while not sacrificing LED optical efficiency relative to conventional packages. Meanwhile, efficiently coupling light from LEDs into modular optical elements, followed by optimally distributing and extracting this light, were challenges that were addressed via novel optical design coupled with frequent experimental evaluations. Minimizing luminaire bill of materials and assembly costs were two guiding principles for all design work, in the effort to achieve luminaires with significantly lower normalized cost ($/klm) than existing LED fixtures. Chief project accomplishments included the achievement of >150 lm/W warm-white LEDs having primary optics compatible with low-cost modular optical elements. In addition, a prototype Light Module optical efficiency of over 90% was measured, demonstrating the potential of this scalable architecture for ultra-high-efficacy LED luminaires. Since the project ended, Cree has continued to evaluate optical element fabrication and assembly methods in an effort to rapidly transfer this scalable, cost-effective technology to Cree production development groups. The Light Module concept is likely to make a strong contribution to the development of new cost-effective, high-efficacy luminaries, thereby accelerating widespread adoption of energy-saving SSL in the U.S.

  15. Shifting the Bell Curve: The Benefits and Costs of Raising Student Achievement (United States)

    Yeh, Stuart S.


    Benefit-cost analysis was conducted to estimate the increase in earnings, increased tax revenues, value of less crime, and reductions in welfare costs attributable to nationwide implementation of rapid assessment, a promising intervention for raising student achievement in math and reading. Results suggest that social benefits would exceed total…

  16. Gender and Education for All: Progress and Problems in Achieving Gender Equity (United States)

    Chisamya, Grace; DeJaeghere, Joan; Kendall, Nancy; Khan, Marufa Aziz


    The paper explores the effects of rapid increases in gender parity in primary schooling in Bangladesh and Malawi on gender inequities in schools and communities. Based on an analysis of comparative case studies of marginalized communities, we argue that educational initiatives focused on achieving gender parity provide limited evidence that girls'…

  17. Modeling Student Test-Taking Motivation in the Context of an Adaptive Achievement Test (United States)

    Wise, Steven L.; Kingsbury, G. Gage


    This study examined the utility of response time-based analyses in understanding the behavior of unmotivated test takers. For the data from an adaptive achievement test, patterns of observed rapid-guessing behavior and item response accuracy were compared to the behavior expected under several types of models that have been proposed to represent…

  18. Science and Mathematics Advanced Placement Exams: Growth and Achievement over Time (United States)

    Judson, Eugene


    Rapid growth of Advanced Placement (AP) exams in the last 2 decades has been paralleled by national enthusiasm to promote availability and rigor of science, technology, engineering, and mathematics (STEM). Trends were examined in STEM AP to evaluate and compare growth and achievement. Analysis included individual STEM subjects and disaggregation…

  19. Machine Vision Implementation in Rapid PCB Prototyping

    Directory of Open Access Journals (Sweden)

    Yosafat Surya Murijanto


    Full Text Available Image processing, the heart of machine vision, has proven itself to be an essential part of the industries today. Its application has opened new doorways, making more concepts in manufacturing processes viable. This paper presents an application of machine vision in designing a module with the ability to extract drills and route coordinates from an un-mounted or mounted printed circuit board (PCB. The algorithm comprises pre-capturing processes, image segmentation and filtering, edge and contour detection, coordinate extraction, and G-code creation. OpenCV libraries and Qt IDE are the main tools used. Throughout some testing and experiments, it is concluded that the algorithm is able to deliver acceptable results. The drilling and routing coordinate extraction algorithm can extract in average 90% and 82% of the whole drills and routes available on the scanned PCB in a total processing time of less than 3 seconds. This is achievable through proper lighting condition, good PCB surface condition and good webcam quality. 

  20. Recent CAS Achievements in Life Sciences

    Institute of Scientific and Technical Information of China (English)


    @@ Recent years have witnessed remarkable progress scored by CAS researchers along with the smooth development of the knowledge innovation program piloted at CAS. The follow-ings are just recent examples of CAS research achievements in life sciences.

  1. The integrated curriculum: experiences, achievements and problems. (United States)

    Gale, J


    In this article the aims, experiences and achievements of vertical and horizontal integration in undergraduate medical education are considered and reviewed, and some problems are identified. It is concluded that a clearer definition of integration would now be helpful.

  2. Cognitive abilities, sociocultural background and academic achievement. (United States)

    Diniz, António; Dias Pocinho, Margarida; Silva Almeida, Leandro


    The influence of students' sociocultural background on academic achievement is a well established fact. Research also points out that sociocultural background is related to students' cognitive abilities and these have an effect on their academic achievement. However, the mediator role of cognitive abilities on the relationship between sociocultural background and academic achievement is less well known. A structural equation model that represents these relationships was tested in a sample (N= 728) of Portuguese junior high school students. Multigroup analysis of the model showed the importance of the cognitive ability mediation effect between sociocultural background and academic achievement in the 7th and 9th grades, but not in the 8th grade. This difference may be the result of the academic transition experienced in the 7th and 9th grades in the Portuguese educational system, which requires parents' higher involvement in school.

  3. Low-Driving-Voltage Optical Modulation Utilizing FWM for High-Speed Transmission Systems

    Institute of Scientific and Technical Information of China (English)

    Akihiko; Matsuura; Toshiya; Matsuda; Tomoyoshi; Kataoka


    We propose an optical transmitter with reduced modulator driving voltage. This reduction is achieved through an on-off ratio improvement technique based on FWM. We confirmed the feasibility of the method in a 43-Gbit/s experiment.

  4. Nonlinear Pulse Compression and Reshaping Using Cross-Phase Modulation in a Dispersion-Shifted Fiber

    Institute of Scientific and Technical Information of China (English)

    S.; W.; Chan; K.; K.; Chow; C.; Shu


    Nonlinear pulse compression has been demonstrated by cross-phase modulation in a dispersion-shifted fiber. The output is obtained from filtering of the broadened optical spectrum and a pulse width reduction from 61 to 28 ps is achieved.

  5. Protein conformational modulation by photons: a mechanism for laser treatment effects. (United States)

    Liebert, Ann D; Bicknell, Brian T; Adams, Roger D


    Responsiveness to low-level laser treatment (LLTT) at a wavelength of 450-910 nm has established it as an effective treatment of medical, veterinary and dental chronic pain, chronic inflammation conditions (arthritis and macular degeneration), wound repair, and lymphoedema, yet the mechanisms underlying the effectiveness of LLLT remain unclear. However, there is now sufficient evidence from recent research to propose an integrated model of LLLT action. The hypothesis presented in this paper is that external applications of photons (through laser at an appropriate dose) modulates the nervous system through an integrated mechanism. This stimulated mechanism involves protein-to-protein interaction, where two or more proteins bind together to facilitate molecular processes, including modification of proteins by members of SUMO (small ubiquitin-related modifier proteins) and also protein phosphorylation and tyrosination. SUMO has been shown to have a role in multiple nuclear and perinuclear targets, including ion channels, and in the maintenance of telomeres and the post-translational modification of genes. The consequence of laser application in treatment, therefore, can be seen as influencing the transmission of neural information via an integrated and rapid modulation of ion channels, achieved through both direct action on photo-acceptors (such as cytochrome c-oxidase) and through indirect modulation via enzymes, including tyrosine hydroxylase (TH), tyrosine kinases and tyrosine kinase receptors. This exogenous action then facilitates an existing photonic biomodulation mechanism within the body, and initiates ion channel modulation both in the periphery and the central nervous system (CNS). Evidence indicates that the ion channel modulation functions predominately through the potassium channels, including two pore leak channels (K2P), which act as signal integrators from the periphery to the cortex. Photonic action also transforms SUMOylation processes at the cell

  6. Factors Affecting Students’ Achievement in Mathematics ∗



    In this study, the factors that affect students’ mathematics achievement in secondary school mathematics grades of 6th, 7th and 8th were explored. For this purpose, the factors that affect mathematics education and mathematics achievement such as type of school, family income, studying time and students’ attitude towards mathematics and attendance to private courses have been investigated. The sample of the study consisted of 275 students from one private (n=58) and two state schools (n= 217)...

  7. Generic ISIS Transport Module Project (United States)

    National Aeronautics and Space Administration — The purpose of the Generic ISIS Transport Module is to provide a means to bring living specimens to and from orbit. In addition to living specimens, the module can...

  8. Bent Electro-Absorption Modulator

    DEFF Research Database (Denmark)


    The present invention relates to a method and a device for modulating optical signals based on modulating bending losses in bend, quantum well semiconductor waveguide sections. The complex refractive index of the optical active semiconducting components of the waveguide section is modulated...... components and the applied electric field in relation to the frequency of the modulated radiation, the bending losses (and possibly coupling losses) will provide extinction of light guided by the bent waveguide section. The refractive index contract may be modulated while keeping the absorption coefficient...... substantially constant and small, whereby the guided light can be modulated only by bending losses. Alternatively, the invention may be applied to enhance the extinction ratio of existing absorption modulators such as Electro-Absorption Modulators (EAMs) in which case extinction by absorption and extinction...

  9. Prime Submodules and Flat Modules

    Institute of Scientific and Technical Information of China (English)



    In this paper, some characterizations of prime submodules in fiat modules and, particularly,in free modules are given. Furthermore, the height of prime submodules and some saturated chain of prime submodules are also given.

  10. Achievement Goals, Learning Strategies and Language Achievement among Peruvian High School Students

    Directory of Open Access Journals (Sweden)

    Lennia Matos


    Full Text Available We used an achievement goal framework to study the role of motivation in the academic context of a Peruvian sample of 8th to 10th grade high school students (N = 1505. The purpose of this cross-sectional study was to examine the relationship between students' achievement goals, their use of learning strategies and their academic achievement. Multiple Hierarchical Regressions Analyses identified, as predicted, positive effects of mastery goals, including more use of learning strategies and higher academic achievement, and negative effects of performance avoidance goals, including lower academic achievement. Mixed results were found for pursuing performance approach goals, which predicted a greater use of learning strategies, but were unrelated to academic achievement. The present findings support the external validity of achievement goal theory in a sample of students from a culture that is understudied in the achievement goal literature in particular and the motivational literature in general.

  11. Rapidity resummation for B-meson wave functions

    Directory of Open Access Journals (Sweden)

    Shen Yue-Long


    Full Text Available Transverse-momentum dependent (TMD hadronic wave functions develop light-cone divergences under QCD corrections, which are commonly regularized by the rapidity ζ of gauge vector defining the non-light-like Wilson lines. The yielding rapidity logarithms from infrared enhancement need to be resummed for both hadronic wave functions and short-distance functions, to achieve scheme-independent calculations of physical quantities. We briefly review the recent progress on the rapidity resummation for B-meson wave functions which are the key ingredients of TMD factorization formulae for radiative-leptonic, semi-leptonic and non-leptonic B-meson decays. The crucial observation is that rapidity resummation induces a strong suppression of B-meson wave functions at small light-quark momentum, strengthening the applicability of TMD factorization in exclusive B-meson decays. The phenomenological consequence of rapidity-resummation improved B-meson wave functions is further discussed in the context of B → π transition form factors at large hadronic recoil.

  12. Code Compliant School Buildings Boost Student Achievement

    Directory of Open Access Journals (Sweden)

    Ronald B. Lumpkin


    Full Text Available Much of the focus in the literature in raising student achievement has included parental involvement, principal leadership, quality of instruction, students’ socioeconomic status, curriculum, and use of technology. Limited empirical research relates the condition of the school building as a variable that affects student achievement. Furthermore, there is no research that has examined the impact of building codes on achievement outcomes in the state of Florida. This research determined whether academic achievement of 4th-, 8th-, 9th-, and 10th-grade students as measured by the mathematics and reading subtests of the Florida Comprehensive Achievement Test (FCAT increased in new school buildings compliant to the 2000 Florida State Requirements for Educational Facilities. A causal-comparative design determined whether the independent variables, old and new school building influenced student achievement as measured by students’ FCAT mathematics and reading subtest scores. The control group was two cohorts of 4th-, 8th-, 9th-, and 10th-grade students who attended school in old buildings. The experimental group was two cohorts of 4th-, 8th-, 9th-, and 10th-grade students who attended school in new buildings. Transition from an old school into a new school was the treatment. Two hypotheses were formulated for testing and the research question for the inquiry was whether the percentage of students passing the FCAT mathematics and reading subtests increases after transitioning from an old school building into a new 2000 UBC (Uniform Building Code compliant facility.


    Directory of Open Access Journals (Sweden)

    Christoph Randler


    Full Text Available Recent psychological studies highlight emotional aspects, and they show an important role within individual learning processes. Hereby, positive emotions were supposed to positively influence learning and achievement processes and negative ones do the contrary. In this study, an educational unit “ecosystem lake” was used during which achievement (three tests and emotional variables (interest, well-being, anxiety and boredom; measured at the end of three pre-selected lessons were monitored. The research question was to explore correlations between emotional variables and the learning outcome of the teaching unit. Prior knowledge was regressed against the subsequent tests to account for its confounding effect. Regressions showed a highly significant influence of prior knowledge on the subsequent measurements of achievement. However, after accounting for prior knowledge, a positive correlation between interest/well-being and achievement and a negative correlation between anxiety/boredom and achievement was found. Further research and interventions should try to enhance positive emotions in biology lessons to positively influence achievement.

  14. Modulation of Translation Initiation Efficiency in Classical Swine Fever Virus

    DEFF Research Database (Denmark)

    Friis, Martin Barfred; Rasmussen, Thomas Bruun; Belsham, Graham J.

    Modulation of translation initiation efficiency on classical swine fever virus (CSFV) RNA can be achieved by targeted mutations within the internal ribosome entry site (IRES). In this study, the nucleotides 47 to 427, including the IRES region of the wt CSFV strain Paderborn, were amplified...

  15. Modulation of Translation Initiation Efficiency in Classical Swine Fever Virus

    DEFF Research Database (Denmark)

    Friis, Martin Barfred; Rasmussen, Thomas Bruun; Belsham, Graham


    Modulation of translation initiation efficiency on classical swine fever virus (CSFV) RNA can be achieved by targeted mutations within the internal ribosome entry site (IRES). In this study, cDNAs corresponding to the wild type (wt) or mutant forms of the IRES of CSFV strain Paderborn were...

  16. Strengthening exercises improve symptoms and quality of life but do not change autonomic modulation in fibromyalgia: a randomized clinical trial.

    Directory of Open Access Journals (Sweden)

    Maria Bernadete Renoldi Oliveira Gavi

    Full Text Available OBJECTIVE: Autonomic dysfunction is an important mechanism that could explain many symptoms observed in fibromyalgia (FM. Exercise is an effective treatment, with benefits potentially mediated through changes in autonomic modulation. Strengthening is one of the less studied exercises in FM, and the acute and chronic effects of strengthening on the autonomic system remain unknown. The objective of this study was to assess the chronic effects of strengthening exercises (STRE on autonomic modulation, pain perception and the quality of life (QOL of FM patients. METHODS: Eighty sedentary women with FM (ACR 1990 were randomly selected to participate in STRE or flexibility (FLEX exercises in a blinded controlled trial. The intensity of STRE was set at 45% of the estimated load of 1 Repetition Maximum (RM in 12 different exercises. Outcomes were Visual Analog Scale (VAS for pain, Heart Rate Variability (HRV analysis, treadmill test, the sit and reach test (Wells and Dillon's Bench, maximal repetitions test and handgrip dynamometry; and quality of life by the Fibromyalgia Impact Questionnaire (FIQ, the Beck and Idate Trait-State Inventory (IDATE, a short-form health survey (SF-36. RESULTS: The STRE group was more effective to strength gain for all muscles and pain control after 4 and 16 weeks (p<0.05. The FLEX group showed higher improvements in anxiety (p<0.05. Both groups showed improvements in the QOL, and there was no significant difference observed between the groups. There was no change in the HRV of the STRE and FLEX groups. CONCLUSIONS: Strengthening exercises show greater and more rapid improvements in pain and strength than flexibility exercises. Despite the benefits in fitness, pain, depression, anxiety and quality of life, no effect was observed on the autonomic modulation in both groups. This observation suggests that changes in autonomic modulation are not a target tobe clinically achieved in fibromyalgia. TRIAL REGISTRATION: Clinical

  17. Performance Evaluation of Passive Optical Network Using Different Modulation Formats (United States)

    Kaur, Ravneet; Dewra, Sanjeev


    In this paper, the performance of passive optical network is analyzed and compared for different modulation formats such as non-return to zero (NRZ), return to zero (RZ) at 2.5 Gb/s bit rate with 16 optical network units. This system is investigated in terms of quality (Q)-factor, optical received power and eye height at different transmission distances. NRZ achieves maximum transmission distance up to 48 km having Q-factor of 6.18 and RZ achieves the maximum transmission distance up to 41 km having Q-factor of 6.21. Furthermore, it is found that NRZ modulation format is more superior and covers more distance as compared to RZ modulation format.

  18. High Efficient Universal Buck Boost Solar Array Regulator SAR Module (United States)

    Kimmelmann, Stefan; Knorr, Wolfgang


    The high efficient universal Buck Boost Solar Array Regulator (SAR) module concept is applicable for a wide range of input and output voltages. The single point failure tolerant SAR module contains 3 power converters for the transfer of the SAR power to the battery dominated power bus. The converters are operating parallel in a 2 out of 3 redundancy and are driven by two different controllers. The output power of one module can be adjusted up to 1KW depending on the requirements. The maximum power point tracker (MPPT) is placed on a separate small printed circuit board and can be used if no external tracker signal is delivered. Depending on the mode and load conditions an efficiency of more than 97% is achievable. The stable control performance is achieved by implementing the magnetic current sense detection. The sensed power coil current is used in Buck and Boost control mode.

  19. Modulational instability of nematic phase

    Indian Academy of Sciences (India)

    T Mithun; K Porsezian


    We numerically observe the effect of homogeneous magnetic field on the modulationally stable case of polar phase in = 2 spinor Bose–Einstein condensates (BECs). Also we investigate the modulational instability of uniaxial and biaxial (BN) states of polar phase. Our observations show that the magnetic field triggers the modulational instability and demonstrate that irrespective of the magnetic field effect the uniaxial and biaxial nematic phases show modulational instability.

  20. On closed weak supplemented modules

    Institute of Scientific and Technical Information of China (English)

    ZENG Qing-yi; SHI Mei-hua


    A module M is called closed weak supplemented if for any closed submodule N of M, there is a submodule K of M such that M=K+N and K(c)N<<M. Any direct summand of closed weak supplemented module is also closed weak supplemented.Any nonsingular image of closed weak supplemented module is closed weak supplemented. Nonsingular V-rings in which all nonsingular modules are closed weak supplemented are characterized in Section 4.

  1. Positron emission tomography and target-controlled infusion for precise modulation of brain drug concentration

    Energy Technology Data Exchange (ETDEWEB)

    Eriksson, Olof [Uppsala Imanet AB, 751 85 Uppsala (Sweden); Department of Radiology, Oncology and Clinical Immunology, Division of Radiology, Uppsala University, 751 85 Uppsala (Sweden)], E-mail:; Josephsson, Ray [Clinical Imaging Unit, Novartis Pharma AG, CH 9057 Basel (Switzerland); Langstrom, Bengt [Uppsala Imanet AB, 751 85 Uppsala (Sweden); Bergstroem, Mats [Department of Pharmaceutical Biosciences, Faculty of Pharmacy, Uppsala University, 751 24 Uppsala (Sweden)


    Introduction: There are several instances when it is desirable to control brain concentration of pharmaceuticals, e.g., to modulate the concentration of anesthetic agents to different desired levels fitting to different needs during the course of surgery. This has so far only been possible using indirect estimates of drug concentration such as assuming constant relation between tissue and blood including extrapolations from animals. Methods: A system for controlling target tissue concentration (UIPump) was used to regulate whole-brain concentrations of a central benzodiazepine receptor antagonist at therapeutic levels with input from brain kinetics as determined with PET. The system was tested by using pharmacological doses of flumazenil mixed with tracer amounts of [{sup 11}C]flumazenil. Flumazenil was used as a model compound for anesthesia. An infusion scheme to produce three different steady-state levels in sequence was designed based on kinetic curves obtained after bolus injection. The subjects (Sprague-Dawley rats, n=6) were monitored in a microPET scanner during the whole experiment to verify resulting brain kinetic curves. Results: A steady-state brain concentration was rapidly achieved corresponding to a whole-brain concentration of 118{+-}6 ng/ml. As the infusion rate decreased to lower the exposure by a factor of 2, the brain concentration decreased to 56{+-}4 ng/ml. A third increased steady-state level of anesthesia corresponding to a whole-brain concentration of 107{+-}7 ng/ml was rapidly achieved. Conclusion: The experimental setup with computerized pump infusion and PET supervision enables accurate setting of target tissue drug concentration.

  2. Achieving Equity: New Ideas for Teacher Education (United States)

    Davis, Brent; Sumara, Dennis


    The route to greater equity in education is tied to a clearer understanding of learning theory, including current research findings that are "game changers" for educators. These "game changers" include rapidly evolving definitions of "learning" and "learners"; an understanding that intelligence and ability are more learned than bestowed; a…

  3. Frequency comb velocity-modulation spectroscopy. (United States)

    Sinclair, Laura C; Cossel, Kevin C; Coffey, Tyler; Ye, Jun; Cornell, Eric A


    We have demonstrated a new technique that provides massively parallel comb spectroscopy sensitive specifically to ions through the combination of cavity-enhanced direct frequency comb spectroscopy with velocity-modulation spectroscopy. Using this novel system, we have measured electronic transitions of HfF⁺ and achieved a fractional absorption sensitivity of 3×10⁻⁷ recorded over 1500 simultaneous channels spanning 150  cm⁻¹ around 800 nm with an absolute frequency accuracy of 30 MHz (0.001  cm⁻¹). A fully sampled spectrum consisting of interleaved measurements is acquired in 30 min.

  4. Frequency Comb Velocity-Modulation Spectroscopy

    CERN Document Server

    Sinclair, Laura C; Coffey, Tyler; Ye, Jun; Cornell, Eric A


    We have demonstrated a new technique that provides massively parallel comb spectroscopy sensitive specifically to ions through the combination of cavity-enhanced direct frequency comb spectroscopy with velocity modulation spectroscopy. Using this novel system, we have measured electronic transitions of HfF+ and achieved a fractional absorption sensitivity of 3 x 10-7 recorded over 1500 simultaneous channels spanning 150 cm-1 around 800 nm with an absolute frequency accuracy of 30 MHz (0.001 cm-1). A fully sampled spectrum consisting of interleaved measurements is acquired in 30 minutes.

  5. A Mediation Analysis of Achievement Motives, Goals, Learning Strategies, and Academic Achievement (United States)

    Diseth, Age; Kobbeltvedt, Therese


    Background: Previous research is inconclusive regarding antecedents and consequences of achievement goals, and there is a need for more research in order to examine the joint effects of different types of motives and learning strategies as predictors of academic achievement. Aims: To investigate the relationship between achievement motives,…

  6. Causal Ordering of Academic Self-Concept and Achievement: Effects of Type of Achievement Measure (United States)

    Pinxten, Maarten; De Fraine, Bieke; Van Damme, Jan; D'Haenens, Ellen


    Background: The relation between academic self-concept and achievement has been examined in a large number of studies. The majority of these studies have found evidence for a reciprocal effects model. However, there is an ongoing debate on how students' achievement should be measured and whether the type of achievement indicator (grades, tests,…

  7. Israeli Water Achievements Today and Enlightenment to China

    Institute of Scientific and Technical Information of China (English)

    Sun Lei; Xu Lanqing


    Despite the endemic drought, arid climate and associated limited freshwater resources, as well as difficult geopolitical realities, Israel can provide a reliable supply of high quality water to a rapidly growing population. The achievements of water supply in Israel can be summarized as water technologies (like water transportation and purification, desalination, wastewater treatment, effluent reuse, storm water catchment, control systems, rain enhancement and drip irrigation, etc.), water management and legislation as well as water industry. In view of the national concern regarding the quality and quantity of the water, the skills, technologies and know-how that Israel has accumulated in water supply and irrigation can give us enlightenment that is also presented in this paper.

  8. Modulation instability: The beginning (United States)

    Noskov, Roman; Belov, Pavel; Kivshar, Yuri


    The study of metal nanoparticles plays a central role in the emerging novel technologies employing optics beyond the diffraction limit. Combining strong surface plasmon resonances, high intrinsic nonlinearities and deeply subwavelength scales, arrays of metal nanoparticles offer a unique playground to develop novel concepts for light manipulation at the nanoscale. Here we suggest a novel principle to control localized optical energy in chains of nonlinear subwavelength metal nanoparticles based on the fundamental nonlinear phenomenon of modulation instability. In particular, we demonstrate that modulation instability can lead to the formation of long-lived standing and moving nonlinear localized modes of several distinct types such as bright and dark solitons, oscillons, and domain walls. We analyze the properties of these nonlinear localized modes and reveal different scenarios of their dynamics including transformation of one type of mode to another. We believe this work paves a way towards the development of nonlinear nanophotonics circuitry.

  9. Silicon optical modulators

    Directory of Open Access Journals (Sweden)

    Graham T. Reed


    Full Text Available Ever since the earliest research on optical circuits, dating back to the 1970s, there have been visions of an optical superchip (see for example1,2, containing a variety of integrated optical components to carry out light generation, modulation, manipulation, detection, and amplification (Fig. 1. The early work was associated with ferroelectric materials such as lithium niobate (LiNbO3, and III-V semiconductors such as gallium arsenide (GaAs and indium phosphide (InP based systems. LiNbO3 was interesting almost solely because of the fact that it possesses a large electro-optic coefficient3, enabling optical modulation via the Pockels effect. Alternatively, the III-V compounds were interesting because of the relative ease of laser fabrication and the prospect of optical and electronic integration.

  10. Stable local oscillator module.

    Energy Technology Data Exchange (ETDEWEB)

    Brocato, Robert Wesley


    This report gives a description of the development of a Stable Local Oscillator (StaLO) multi-chip module (MCM). It is a follow-on report to SAND2006-6414, Stable Local Oscillator Microcircuit. The StaLO accepts a 100MHz input signal and produces output signals at 1.2, 3.3, and 3.6 GHz. The circuit is built as a multi-chip module (MCM), since it makes use of integrated circuit technologies in silicon and lithium niobate as well as discrete passive components. This report describes the development of an MCM-based version of the complete StaLO, fabricated on an alumina thick film hybrid substrate.

  11. Silicon Optical Modulator Simulation

    Directory of Open Access Journals (Sweden)

    Soon Thor LIM


    Full Text Available We developed a way of predicting and analyzing high speed optical modulator. Our research adopted a bottom-up approach to consider high-speed optical links using an eye diagram. Our method leverages on modular mapping of electrical characteristics to optical characteristics, while attaining the required accuracy necessary for device footprint approaching sub-micron scales where electrical data distribution varies drastically. We calculate for the bias dependent phase shift (2pi/mm and loss (dB/mm for the optical modulator based on the real and imaginary part of complex effective indices. Subsequently, combine effectively both the electrical and optical profiles to construct the optical eye diagram which is the essential gist of signal integrity of such devices.

  12. Modulators of decision making. (United States)

    Doya, Kenji


    Human and animal decisions are modulated by a variety of environmental and intrinsic contexts. Here I consider computational factors that can affect decision making and review anatomical structures and neurochemical systems that are related to contextual modulation of decision making. Expectation of a high reward can motivate a subject to go for an action despite a large cost, a decision that is influenced by dopamine in the anterior cingulate cortex. Uncertainty of action outcomes can promote risk taking and exploratory choices, in which norepinephrine and the orbitofrontal cortex appear to be involved. Predictable environments should facilitate consideration of longer-delayed rewards, which depends on serotonin in the dorsal striatum and dorsal prefrontal cortex. This article aims to sort out factors that affect the process of decision making from the viewpoint of reinforcement learning theory and to bridge between such computational needs and their neurophysiological substrates.


    Directory of Open Access Journals (Sweden)

    Mohale Deepak S.


    Full Text Available Anxiety can be a core symptom of various mental/ behavioral disorders such as major depressive disorders, obsessive-compulsive disorders, panic disorder, adaptive disorder, post-traumatic stress disorder, social withdrawal disorder, and various phobias. The neuroanatomic circuits that support fear and anxiety behavior are modulated by a variety of neurochemicals, these include the peptidergic neurotransmitters, Corticotrophin releasing factor (CRF, neuropeptide Y (NPY, and substance P, the monoaminergic transmitters, Norepinephrine (NE, serotonin (5-hydroxytryptamine or 5-HT, and dopamine (DA, and the amino acid transmitters, Gamma Aminobuteric Acid (GABA and glutamate and many more. These neurochemical systems subserve important adaptive functions in preparing the organism for responding to threat or stress, by increasing vigilance, modulating memory, mobilizing energy stores, and elevating cardiovascular function. Nevertheless, these biological responses to threat and stress can become maladaptive if they are chronically or inappropriately activated.

  14. A Scalable Module System

    CERN Document Server

    Rabe, Florian


    Symbolic and logic computation systems ranging from computer algebra systems to theorem provers are finding their way into science, technology, mathematics and engineering. But such systems rely on explicitly or implicitly represented mathematical knowledge that needs to be managed to use such systems effectively. While mathematical knowledge management (MKM) "in the small" is well-studied, scaling up to large, highly interconnected corpora remains difficult. We hold that in order to realize MKM "in the large", we need representation languages and software architectures that are designed systematically with large-scale processing in mind. Therefore, we have designed and implemented the MMT language -- a module system for mathematical theories. MMT is designed as the simplest possible language that combines a module system, a foundationally uncommitted formal semantics, and web-scalable implementations. Due to a careful choice of representational primitives, MMT allows us to integrate existing representation l...

  15. Lightweight Trauma Module - LTM (United States)

    Hatfield, Thomas


    Current patient movement items (PMI) supporting the military's Critical Care Air Transport Team (CCATT) mission as well as the Crew Health Care System for space (CHeCS) have significant limitations: size, weight, battery duration, and dated clinical technology. The LTM is a small, 20 lb., system integrating diagnostic and therapeutic clinical capabilities along with onboard data management, communication services and automated care algorithms to meet new Aeromedical Evacuation requirements. The Lightweight Trauma Module is an Impact Instrumentation, Inc. project with strong Industry, DoD, NASA, and Academia partnerships aimed at developing the next generation of smart and rugged critical care tools for hazardous environments ranging from the battlefield to space exploration. The LTM is a combination ventilator/critical care monitor/therapeutic system with integrated automatic control systems. Additional capabilities are provided with small external modules.

  16. fast,rapid,quick和speedy

    Institute of Scientific and Technical Information of China (English)



    fast,rapid,quick和speedy这组词都有“快的”意思,但将它们放在一起略作议论,仍有必要,并不乏词趣。 fast和rapid虽然有时可以互换使用,彼此仍有差异,fast在作形容词的时候,强调物体进行相对运动。如a fast horse,a fast train.除形容词外,fast可做副词。如:

  17. The Experimental Study on Acousto-optic Modulation Based on Single-mode Fiber Fused Coupler

    Institute of Scientific and Technical Information of China (English)

    Liu Guoxiang; Hu Li; Ye Kunzhen; Lin Weigan


    In-line acoustic-optic (AO) modulation experiments were demonstrated based on the acoustic-optic effect in optical fiber fused taper couplers.About 73%,64%,and 61% modulation have been achieved at frequencies of 0.169 MHz,0.367 MHz and 0.521 MHz with an electrical driving power less than 10 mW,respectively.

  18. The Effectiveness of a Virtual Field Trip (VFT) Module in Learning Biology (United States)

    Haris, Norbaizura; Osman, Kamisah


    Virtual Field Trip is a computer aided module of science developed to study the Colonisation and Succession in Mangrove Swamps, as an alternative to the real field trip in Form for Biology. This study is to identify the effectiveness of the Virtual Field Trip (VFT) module towards the level of achievement in the formative test for this topic. This…

  19. Modulation Frequency Multiplexed Tunable Diode Laser Spectroscopy System for Simultaneous CO, CO2 Measurements

    Institute of Scientific and Technical Information of China (English)

    CHEN Dong; LIU Wen-Qing; ZHANG Yu-Jun; LIU Jian-Guo; WEI Qing-Nong; KAN Rui-Feng; WANG Min; CUI Yi-Ben; CHEN Jiu-Ying


    @@ A modulation frequency multiplexed dual diode-laser system is developed for simultaneous detection of the two most common fire gas products CO and CO2. Simultaneous detection is achieved by modulating each laser at different frequencies, demodulating the signal by a pair of lock-in amplifiers for each gas.

  20. -k-torsionfree modules and

    Institute of Scientific and Technical Information of China (English)


    The notion of ω-k-torsionfree modules with respect to a bimoduleω is introduced, which is characterized in terms of left addR ω-approximations. The notion of ω-left approximation dimension is introduced, and the forms of k-syzygy modules being k-torsionfree modules are described.